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NIBU Kenichi
Graduate School of Medicine / Faculty of Medical Sciences
Professor

Researcher basic information

■ Research Areas
  • Life sciences / Otorhinolaryngology

Research activity information

■ Paper
  • Ayu Akazawa, Takeshi Fujita, Jun Yokoi, Natsumi Uehara, Mie Kubo, Akinobu Kakigi, Ken‐ichi Nibu
    Aug. 2025, Laryngoscope Investigative Otolaryngology
    Scientific journal

  • Hidehito Kimura, Ken‐ichi Nibu, Tatsuya Furukawa, Yuto Horichi, Hirotaka Shinomiya, Tadashi Nomura, Yoichi Uozumi, Eiji Kohmura, Takashi Sasayama
    Jul. 2025, Head & Neck
    Scientific journal

  • Kenya Kobayashi, Seiichi Yoshimoto, Koji Yamamura, Megumi Kitayama, Daisuke Kawakita, Ken‐Ichi Nibu, Kenji Kondo, Yuki Saito
    Jul. 2025, The Laryngoscope
    Scientific journal

  • Hidetoshi Matsui, Hidetaka Eguchi, Yasushi Okazaki, Yuji Hirayama, Ken‐Ichi Nibu, Hirotaka Shinomiya
    Jun. 2025, Head & Neck
    Scientific journal

  • Yuto Horichi, Hirotaka Shinomiya, Megumi Kitayama, Daisuke Kawakita, Takeshi Kodaira, Munenaga Nakamizo, Seiichi Yoshimoto, Ken‐ichi Nibu
    Apr. 2025, Head & Neck
    Scientific journal

  • Daisuke Kawakita, Seiichi Yoshimoto, Munenaga Nakamizo, Megumi Kitayama, Tadaaki Kirita, Takeshi Kodaira, Toshifumi Tomioka, Ryosuke Kamiyama, Hideaki Takahashi, Hideki Nakayama, Yoshio Ohyama, Yuji Murakami, Ken-Ichi Nibu
    OBJECTIVE: The Head and Neck Cancer Registry, supported by the Japan Society for Head and Neck Cancer, was re-established in 2012 after renewal of the contents and methods of registration. METHODS: The registry registers patients with previously untreated, histologically confirmed malignant tumors of the head and neck, including the oral cavity, larynx, hypopharynx, oropharynx, nasopharynx, nasal cavity and paranasal sinus, major salivary gland, and cervical nodal involvement with an unknown primary. RESULTS: The total number of registered patients reached more than 150,000 as of June 2024. We have published reports of important real-world evidence from the registry data. CONCLUSION: We believe that this nation-wide, organ-based registry aids understanding of the epidemiology and treatment strategies of head and neck cancer, in addition to hospital-based and national cancer registries in Japan.
    Jan. 2025, Auris, nasus, larynx, 52(2) (2), 122 - 126, English, International magazine
    Scientific journal

  • Mariko Tsujimoto, Takeshi Fujita, Tatsuya Furukawa, Yaeno Arima, Ken-Ichi Nibu, Chikako Nishigori
    BACKGROUND: Xeroderma pigmentosum (XP) is caused by impaired DNA repair of UV-induced dipyrimidine-photoproducts. XP cells also show impaired repair/removal of ROS or oxidative DNA lesions caused by UV or 4-nitroquinolline 1-oxide (4NQO). Gene profiling indicated that inflammatory response-related genes are significantly upregulated after UV exposure in XP-A model mice. OBJECTIVE: Since XP cells are in the state of oxidative stress and inflammation, we aimed to search for therapeutic agents from anti-oxidants/anti-inflammatory drugs, that potentially improve XP symptoms. METHODS: Several antioxidants were examined for reducing 4NQO-induced oxidative cytotoxicity or UV-induced oxidative DNA damage in XP-A cells. Among them, we focused on melatonin and evaluated its improving effect for Xpa-deficient MEF on UV-induced cytotoxicity and ROS production, and for Xpa-deficient mice on UV-induced skin tumorigenesis and auditory brainstem responses as one of the neurological symptoms. RESULTS: Melatonin and nicotinamide attenuated 4NQO-induced oxidative cytotoxicity. UV-induced intracellular ROS production and cytotoxicity were improved by melatonin for Xpa-deficient MEF. Finally, the administration of melatonin mitigated UV-induced skin inflammation and tumorigenesis and suppressed hearing deterioration in Xpa-deficient mice. CONCLUSION: Our results show that melatonin could alleviate XP symptoms through its anti-inflammatory and antioxidant properties.
    Jan. 2025, Journal of dermatological science, English, International magazine
    Scientific journal

  • Takashi Ueda, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Mitsuko Yui, Ayu Akazawa, Toshihiko Yamashita, Yukako Goto, Akinobu Kakigi, Ken-Ichi Nibu
    Bilateral congenital cholesteatoma (BCC) is rare among congenital cholesteatoma (CC) cases, and bilateral surgery poses a significant psychophysical burden on pediatric patients. Here, we present 2 pediatric cases of BCC that were successfully managed using simultaneous bilateral transcanal endoscopic ear surgery (TEES). The surgical approach provided clear visualization of the middle ear structures, enabling successful cholesteatoma removal with minimal invasiveness and a short operative time. In both cases, follow-up computed tomography showed no recurrence, and pure-tone audiometry results demonstrated good outcomes. Simultaneous bilateral TEES can be a viable option for pediatric BCC, as it reduces patient burden due to its less invasive procedure and short operative time.
    Nov. 2024, The journal of international advanced otology, 20(6) (6), 540 - 542, English, International magazine
    Scientific journal

  • 折舘 伸彦, 川北 大介, 猪原 秀典, 守本 倫子, 丹生 健一
    日本臨床ウイルス学会, Oct. 2024, 臨床とウイルス, 52(4) (4), 239 - 244, Japanese

  • 藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ
    (一社)日本耳鼻咽喉科頭頸部外科学会, Oct. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(10) (10), 1064 - 1071, Japanese

  • 当院におけるアッシャー症候群の検討
    上原 奈津美, 横井 純, 藤田 岳, 西尾 信哉, 柿木 章伸, 松永 達雄, 宇佐美 真一, 丹生 健一
    (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 185 - 185, Japanese

  • 神経線維種症II型(NF2)に対して人工内耳植込術を施行した2症例
    赤座 暁子, 藤田 岳, 上原 奈津美, 横井 純, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 220 - 220, Japanese

  • OTOPLANを用いたFLEXsoft人工内耳電極の周波数ミスマッチに関する検討
    横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 242 - 242, Japanese

  • グロムス腫瘍との鑑別に苦慮した側頭骨内顔面神経鞘腫の1例
    渡辺 啓太, 藤田 岳, 横井 純, 柿木 章伸, 上原 奈津美, 丹生 健一
    (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 272 - 272, Japanese

  • 長期抗菌薬投与を継続しながら外来治療に移行した頭蓋底骨髄炎の一例
    水本 真理愛, 上原 奈津美, 小池 雪絵, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 295 - 295, Japanese

  • 横井 純, 藤田 岳, 山下 俊彦, 柿木 章伸, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2024, Equilibrium Research, 83(5) (5), 396 - 396, Japanese

  • Toshihiro Ichisaka, Daisuke Sano, Natsumi Kijima, Daisuke Kawakita, Seiichi Yoshimoto, Megumi Kitayama, Ken-Ichi Nibu, Nobuhiko Oridate
    BACKGROUND: T2N0 glottic squamous cell carcinoma (SCC) typically responds well to radiotherapy (RT); however, achieving local control remains challenging. In cases of RT failure, total laryngectomy may be necessary. Improved local control and preservation of the larynx directly enhances patients' quality of life. Our retrospective analysis using the Japan Head and Neck Cancer Registry (JHNCR) aimed to compare the clinical benefits of RT and chemoradiotherapy (CRT) in patients with T2N0 glottic SCC. METHODS: Using data from the JHNCR (2011-2015), we included 1,231 patients with T2N0 glottic SCC. Among them, 346 received curative RT and 425 underwent curative CRT. The CRT group was further divided into the oral CRT (Oral CRT, N=120) and intravenous CRT (DIV CRT, N=305) groups. This study assessed local control rate (LCR), progression-free survival (PFS), and overall survival (OS). A 1:1 propensity score-matching analysis was used to adjust for patient characteristics. RESULTS: After matching, 105 pairs compared RT with Oral CRT, and 224 pairs compared RT with DIV CRT. The variables were well-balanced in the matched populations. In the matched populations, the Oral CRT group had significantly better 5-year LCR and PFS than the RT group (LCR, 89.4 % vs. 80.6 %, P=0.043; and PFS, 85.5 % vs. 72.3 %, P=0.025, respectively), while the DIV RT group had significantly better 5-year PFS than the RT group (80.1 % vs. 68.6 %, P=0.026). CONCLUSIONS: The clinical benefits of better local and disease controls were observed when oral chemotherapy was added to RT in patients with T2N0 glottic SCC. Thus, the significance of adding oral chemotherapeutic agents to RT in the treatment of T2N0 glottic SCC requires further prospective investigation.
    Oct. 2024, Oral oncology, 157, 106942 - 106942, English, International magazine
    Scientific journal

  • 藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ
    (一社)日本耳鼻咽喉科頭頸部外科学会, Oct. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(10) (10), 1064 - 1071, Japanese

  • Yoshiaki Nagatani, Naomi Kiyota, Yoshinori Imamura, Taiji Koyama, Yohei Funakoshi, Masato Komatsu, Tomoo Itoh, Masanori Teshima, Ken-Ichi Nibu, Kazuko Sakai, Kazuto Nishio, Manami Shimomura, Tetsuya Nakatsura, Daiki Ikarashi, Takayuki Nakayama, Shigehisa Kitano, Hironobu Minami
    AIM: Although immune checkpoint inhibitors (ICPi) for salivary gland cancer (SGC) have been investigated in clinical trials, details of the tumor immune microenvironment (TIME) remain unclear. This research aimed to elucidate the TIME of SGC and its relationship with tumor mutation burden (TMB) and to explore the rationale for the applicability of ICPi. MATERIALS AND METHODS: We selected five pathological types, namely adenoid cystic carcinoma (ACC); adenocarcinoma, not otherwise specified (ANOS); salivary duct carcinoma (SDC); and low/high-grade mucoepidermoid carcinoma (MEClow/high). We investigated the TIME and TMB of each pathological type. TIME was evaluated by multiplexed fluorescent immunohistochemistry. TMB was measured by next-generation sequencing. RESULTS: ACC and MEChigh showed the lowest and highest infiltration of immune effector and suppressor cells in both tumor and stroma. ANOS, SDC, and MEClow showed modest infiltration of immune effector cells in tumors. Correlation analysis showed a positive correlation between CD3+CD8+ T cells in tumor and TMB (r = 0.647). CD3+CD8+ T cells in tumors showed a positive correlation with programmed cell death-ligand 1 expression in tumor cells (r = 0.513) and a weak positive correlation with CD3+CD4+Foxp3+ cells in tumors (r = 0.399). However, no correlation was observed between CD3+CD8+ T cells and CD204+ cells in tumors (r = -0.049). CONCLUSION: The TIME of ACC was the so-called immune desert type, which may explain the mechanisms of the poor response to ICPi in previous clinical trials. On the other hand, MEChigh was the immune-inflamed type, and this may support the rationale of ICPi for this pathological subtype.
    Sep. 2024, Asia-Pacific journal of clinical oncology, English, International magazine
    Scientific journal

  • 櫻井 結華, 藤田 岳, 森田 由香, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ
    (一社)日本耳鼻咽喉科頭頸部外科学会, Sep. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(9) (9), 994 - 1003, Japanese

  • 岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2024, Audiology Japan, 67(5) (5), 448 - 448, Japanese

  • オピオイド鎮痛薬を入院中に開始した外来頭頸部がん患者を対象とした病院薬剤師による電話サポート介入の効果
    志田 有里, 飯田 真之, 番匠 咲帆, 蓼原 瞬, 大本 暢子, 山本 和宏, 大村 友博, 丹生 健一, 矢野 育子
    (一社)日本緩和医療薬学会, Sep. 2024, 日本緩和医療薬学雑誌, 17(3) (3), 87 - 94, Japanese

  • Misato Ueda, Hirotaka Shinomiya, Ken-Ichi Nibu, Hidehito Kimura, Tadashi Nomura
    In cases of lacrimal gland carcinoma requiring surgical excision of the orbital contents, skull base, and surrounding bones, definitive blockage of the cranial cavity and reconstruction of the anterior skull base with irradiation-acceptable tissue (for possible subsequent radiotherapy) is necessary. However, considerations for quality of life, including cosmetic aspects, such as artificial eye placement and contour morphology, make reconstruction challenging. In three cases of advanced lacrimal gland carcinoma, we performed a reconstruction surgery following an en bloc resection of the orbital contents and lateral orbital bones. A rectus abdominis flap was used, considering both function and morphology. This flap, characterized by reliable anatomical structure and good blood flow, adequately filled the three-dimensional dead space. In our case, the flap fully survived, and no complications such as cerebrospinal fluid leakage or meningitis were observed. Six months after surgery, the flap volume was 31.7-73.3% of its initial size. Considering potential flap shrinkage in the future, it was deemed beneficial to use a slightly excessive volume.
    Sep. 2024, Cureus, 16(9) (9), e69310, English, International magazine
    Scientific journal

  • Ken-Ichi Nibu, Nobuhiko Oridate, Yuki Saito, Montserrat Roset, Marta Forés Maresma, Daniel Cuadras, Edith Morais, Craig Roberts, Ya-Ting Chen, Jacque Spitzer, Kayo Sato, Itori Saito, Ichiro Tazaki, Omar Clavero, Lea Schroeder, Laia Alemany, Hisham Mehanna, Haitham Mirghani, Anna R Giuliano, Miquel Angel Pavón, Tim Waterboer
    There is limited understanding of epidemiology and time trends of human papilloma virus (HPV)-driven head and neck cancers (HNC) in Japan, especially outside of the oropharynx. To assess HPV-driven HNC, a non-interventional study (BROADEN) of HNC patients diagnosed in 2008-2009 and 2018-2019 was conducted in Japan. Adult patients with oropharyngeal, nasopharyngeal, laryngeal, hypopharyngeal or oral cavity cancers were included in this study. HPV was centrally tested using p16INK4a immunohistochemistry, HPV-DNA PCR and HPV E6*I mRNA. HPV attributability required positivity in at least two tests (p16INK4a immunohistochemistry, HPV-DNA PCR, HPV E6*I mRNA) in the oropharynx, and HPV-DNA and HPV E6*I mRNA positivity for non-oropharynx sites. Nineteen hospitals included a total of 1108 patients, of whom 981 had valid samples. Men accounted for 82% of HNC diagnoses. Patients in the earlier cohort were younger and included a higher percentage of smokers. There was an increasing trend of HPV-driven oropharyngeal cancer over the last decade, from 44.2% to 51.7%. HPV attribution in nasopharyngeal cancers was 3.2% in 2008-2009 and 7.5% in 2018-2019; and 4.4% and 0% for larynx respectively. In total, 95.2% of HPV-driven HNC were attributed to HPV genotypes included in the 9-valent HPV vaccine being HPV16 the most prominent genotype. These results suggest that an epidemiologic shift is happening in Japan, with a decrease in smoking and alcohol use and an increase in HPV-driven HNC. The increasing trend of HPV-driven HNC in Japan highlights the need for preventive strategies to mitigate the rise of HPV-driven HNC.
    Aug. 2024, Cancer science, 115(8) (8), 2808 - 2818, English, International magazine
    Scientific journal

  • Hajime Fujiwara, Yoshinori Kodama, Hikari Shimoda, Masanori Teshima, Hirotaka Shinomiya, Ken-ichi Nibu
    Aug. 2024, Auris Nasus Larynx
    Scientific journal

  • Ryoichiro Kashiwagi, Hayato Maruguchi, Nibu Ken-Ichi, Hiroto Terashi, Tadashi Nomura
    Myxomas, when they manifest in the paranasal sinuses and/or maxillae of infants, are classified as sinonasal myxomas (SNMs). We present a case of SNM in the maxilla of a 15-month-old infant. Following the initial surgical intervention, the patient unfortunately experienced a recurrence of the condition. However, a subsequent surgery employing marginal excision was performed, and since then, no further recurrence has been reported. SNM exhibits consistent clinical features and histological characteristics that are distinct from those of odontogenic myxomas. Furthermore, in this case, immunohistochemical staining was positive for β-catenin, whereas odontogenic myxomas are generally negative for β-catenin staining. Another study reported that SNMs share genetic mutations with desmoid tumors, which are not observed in odontogenic myxomas. This suggests that this entity is distinct from odontogenic myxomas, leading us to propose that it may indeed represent a separate disease entity. This fact may lead to the reclassification of the disease and, ultimately, to changes in treatment strategies.
    Aug. 2024, Cureus, 16(8) (8), e65933, English, International magazine
    Scientific journal

  • 齊藤 祐毅, 丹生 健一
    (株)癌と化学療法社, Jul. 2024, 癌と化学療法, 51(7) (7), 704 - 708, Japanese

  • Mitsuko Yui, Yoshihisa Matsuno, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Naomi Kiyota, Tadashi Nomura, Daisuke Miyawaki, Ryohei Sasaki, Ken-Ichi Nibu
    Background Since the larynx and pharynx are vital for respiration, swallowing, and speech, chemoradiotherapy (CRT) has been widely applied for T3 hypopharyngeal cancer (HPC) as an organ-preserving treatment. However, CRT can lead to severe late adverse events such as dysphagia and aspiration pneumonia, especially in patients who have difficulty swallowing and/or aspiration at the time of initial diagnosis. Patients and methods Between 2012 and 2020, 86 patients with T3 HPC treated with curative intent at Kobe University Hospital were included in this study. The average age was 69 years old, ranging from 43 to 89. Diseases were classified as Stage III in 29 patients, Stage IVA in 52 patients, and Stage IVB in five patients. Thirty-five (41%) patients were treated by CRT, and 51 (59%) patients were treated by surgery. Patients were followed up for at least two years, and the follow-up period ranged from four to 128 months (median: 45 months). Results Three-year progression-free survival (PFS) rates of patients treated by CRT and patients treated by surgery were 56.2% and 60.3%, respectively. Three-year disease-specific survival (DSS) rates of patients treated by CRT and surgically treated patients were 79.0% vs. 70.8%, respectively. Three-year overall survival (OS) rates of patients treated by CRT and surgically treated patients were 64.5% and 69.0%, respectively. Of note, a significant difference was observed between three-year DSS and three-year PFS (79.0% vs. 56.2%, p = 0.0014) in the patients treated by CRT but not in the patients treated by surgery. Conclusions No significant differences were observed between the PFS, DSS, and OS rates of patients treated by CRT and those of surgically treated patients. Locoregional recurrences after CRT were significantly successfully salvaged by surgical intervention. These results suggest that CRT can be applied as an alternative to surgery without reducing survival, especially for patients without severe clinical symptoms. Meticulous follow-up is mandatory for early detection of recurrence to salvage by surgery and for the management of late adverse events.
    Jun. 2024, Cureus, 16(6) (6), e62553, English, International magazine
    Scientific journal

  • Go Inokuchi, Mihoko Mine, Kotaro Tamagawa, Shun Tatehara, Mitsuko Yui, Youichi Uozumi, Yuichi Fujita, Tomoaki Nakai, Ken-Ichi Nibu
    OBJECTIVE: Landmark arteries during endoscopic sinus surgery are currently identified on the basis of anatomy, CT imaging and navigation, and Doppler flowmetry. However, the advantage of intraoperative fluorescence imaging during endoscopic sinus surgery has not been demonstrated. This study aimed to investigate whether Indocyanine Green (ICG) is useful for visualizing landmark arteries during endoscopic sinus and skull base surgery. METHODS: Eight patients who underwent endoscopic sinus and pituitary surgeries and consented to study participation were included. After planned procedures were performed as usual, landmark arteries were examined by ICG endoscope. Recorded video and preoperative CT images were analyzed for identification of five landmark arteries: anterior ethmoidal artery (AEA), posterior ethmoidal artery (PEA), internal carotid artery (ICA), sphenopalatine artery (SPA), and postnasal artery (PNA). Identification of arteries was evaluated three grades: identifiable, locatable, unrecognizable. RESULTS: Eight patients and eleven sides were evaluated. The ICG dose was 2.5 mg/body and a single shot was sufficient for evaluation. 100 % of AEA was identified (9/9 sides), 86 % of PNA (6/7 sides), 56 % of ICA (5/9 sides), and 25 % of PEA and SPA (2/8 sides). CONCLUSION: ICG could visualize landmark arteries, even thin arteries like AEA, during endoscopic sinus and skull base surgeries. Visualization was affected by thickness of bone or soft tissue above arteries, blood clots, sensitivity setting, and angle and distance of near-infrared light irradiation. ICG visualization of landmark arteries may help avoid vascular injuries during endoscopic sinus and skull base surgeries, particularly of AEA, PNA and ICA.
    May 2024, American journal of otolaryngology, 45(4) (4), 104343 - 104343, English, International magazine
    Scientific journal

  • 頭頸部領域の肉腫における組織型別の臨床的特徴 頭頸部悪性腫瘍全国登録からの報告
    小林 謙也, 山村 晃司, 齊藤 祐毅, 北山 恵, 川北 大介, 吉本 世一, 丹生 健一
    (一社)日本頭頸部癌学会, May 2024, 頭頸部癌, 50(2) (2), 145 - 145, Japanese

  • 頭頸部全国悪性腫瘍登録データベースを利用した局所進行下咽頭癌の治療法別予後の検討
    堀地 祐人, 藤原 肇, 由井 光子, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 北山 恵, 川北 大介, 桐田 忠昭, 古平 毅, 吉本 世一, 中溝 宗永, 丹生 健一
    (一社)日本頭頸部癌学会, May 2024, 頭頸部癌, 50(2) (2), 184 - 184, Japanese

  • 頭頸部悪性腫瘍全国登録データを用いた嗅神経芽細胞腫の臨床統計
    関水 真理子, 岡田 峻, 石川 直明, 永井 遼斗, 御子柴 卓弥, 丹生 健一, 吉本 世一, 川北 大介, 小澤 宏之
    (一社)日本頭頸部癌学会, May 2024, 頭頸部癌, 50(2) (2), 192 - 192, Japanese

  • Satoshi Seno, Kazuma Iwashita, Akifumi Kajiwara, Rie Sasaki, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Kiyota N, Rod Lynch, Kenji Yoshida, Takeaki Ishihara, Daisuke Miyawaki, Ken-ichi Nibu, Ryohei Sasaki
    May 2024, Cancers
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 頭頸部領域の肉腫における組織型別の臨床的特徴 頭頸部悪性腫瘍全国登録からの報告
    小林 謙也, 山村 晃司, 齊藤 祐毅, 北山 恵, 川北 大介, 吉本 世一, 丹生 健一
    (一社)日本頭頸部癌学会, May 2024, 頭頸部癌, 50(2) (2), 145 - 145, Japanese

  • 折舘 伸彦, 川北 大介, 猪原 秀典, 守本 倫子, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(4) (4), 417 - 417, Japanese

  • Makiko Hara, Sumiyo Saburi, Natsumi Uehara, Takahiro Tsujikawa, Mie Kubo, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Shigeru Hirano, Ken-Ichi Nibu
    BACKGROUND: The goal of this study was to evaluate the antitumor immune effects of B7-1 gene expression in addition to immune checkpoint inhibitor against squamous cell carcinoma. METHODS: A murine SCC cell line, KLN205, was infected with adenoviral vector carrying B7-1 (AdB7). Infected cells were injected subcutaneously in the flanks of DBA/2 mice. Three weeks after implantation, anti-mouse PD-1 antibody (antiPD1) was intraperitonially administrated twice a week for a total of six times. RESULTS: CD80 was significantly overexpressed in the AdB7-infected tumors. IFN-gamma in the T cells in the spleen was significantly increased and tumor size was significantly reduced in the mice treated with both AdB7 and antiPD1. Targeted tumors treated with both AdB7 and antiPD1 exhibited significantly increased cell densities of total immune cells as well as Ki-67+ CD8+ T cells and decreased regulatory T cells. CONCLUSIONS: These results suggest that the B7-1 gene transfer may enhance the antitumor effect of anti-PD1 antibody against SCC.
    Mar. 2024, Cancers, 16(7) (7), English, International magazine
    Scientific journal

  • 上原 奈津美, 神澤 真紀, 横井 純, 由井 光子, 井之口 豪, 藤田 岳, 柿木 章伸, 丹生 健一
    日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会誌, 4(1) (1), 31 - 36, Japanese

  • 好酸球性副鼻腔炎に対するバイオ製剤治療による中耳炎への効果の検討
    上原 奈津美, 由井 光子, 藤田 岳, 井之口 豪, 柿木 章伸, 丹生 健一
    日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 4回, 216 - 216, Japanese

  • Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu
    The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.
    Jan. 2024, The Kobe journal of medical sciences, 69(4) (4), E144-E150, English, Domestic magazine
    Scientific journal

  • 上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese

  • 上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese

  • Koichi Yasuda, Yusuke Uchinami, Satoshi Kano, Jun Taguchi, Daisuke Kawakita, Megumi Kitayama, Kentaro Nishioka, Takashi Mori, Fuki Koizumi, Yuri Fujii, Yasushi Shimizu, Keiji Kobashi, Seiichi Yoshimoto, Ken-Ichi Nibu, Akihiro Homma, Hidefumi Aoyama
    BACKGROUND: Whether concurrent chemotherapy with radiotherapy (CRT) is effective for elderly patients with head and neck cancer is a controversial topic. This study aimed to analyze the effectiveness of CRT vs. radiation therapy (RT) among elderly patients in Japan. METHODS: Data from the Head and Neck Cancer Registry of Japan were extracted and analyzed. Patients with locally advanced squamous cell carcinoma of the oropharynx, hypopharynx, or larynx who received definitive CRT or RT between 2011 and 2014 were included. RESULTS: CRT was administered to 78% of the 1057 patients aged ≥ 70 years and 67% of the 555 patients aged ≥ 75 years. For the patients aged ≥ 75 years, the overall survival (OS) rate was significantly better in the CRT group than in the RT group (P < 0.05), while the progression-free survival (PFS) rate was not significantly different (P > 0.05). The add-on effect of CRT was significantly poor in elderly patients (P < 0.05), and it was not a significant factor in the multivariate analysis for patients aged ≥ 75 years. After propensity score matching, there were no significant differences in the OS and PFS rates between the patients aged ≥ 70 years and those aged ≥ 75 years (all, P > 0.05). CONCLUSION: Although aggressive CRT is administered to elderly patients in Japan, its effectiveness is uncertain. Further prospective randomized trials are needed to verify whether CRT is superior to RT alone for elderly patients.
    Dec. 2023, International journal of clinical oncology, English, Domestic magazine
    Scientific journal

  • 岩城 忍, 柿木 章伸, 藤田 岳, 上原 奈津美, 横井 純, 丹生 健一
    (一社)日本聴覚医学会, Dec. 2023, Audiology Japan, 66(6) (6), 544 - 551, Japanese

  • Daiki Kitano, Kazunobu Hashikawa, Tatsuya Furukawa, Tadashi Nomura, Kotaro Tamagawa, Shunsuke Sakakibara, Ken-Ichi Nibu, Hiroto Terashi
    We report a case of a second free jejunal transfer to treat metastasis in the mesenteric lymph node of the first jejunal flap. A 73-year-old man underwent total pharyngolaryngectomy, bilateral neck dissection, and free jejunal transfer for recurrent hypopharyngeal cancer [left pyriform sinus, pT2N0, moderately differentiated squamous cell carcinoma (SCC)] after radiotherapy. Seven years post-surgery, he underwent transoral videolaryngoscopic surgery for oropharyngeal cancer (soft palate, pT1N0, well-differentiated SCC). Ten years after the first jejunal transfer, metastasis was found in the mesenteric lymph node surrounding the jejunal flap's vascular pedicle. Under general anesthesia, resection of the first jejunum including the affected lymph node, and second jejunal transfer were performed. Lymph node pathological examination revealed poorly differentiated SCC, compatible with pharyngeal cancer metastasis. After neck dissection and jejunal flap transfer, lymphatic collateral pathways toward the flap's mesenteric lymph node might form. Possibly, hypopharyngeal or oropharyngeal cancer metastasized via this pathway.
    Dec. 2023, Journal of surgical case reports, 2023(12) (12), rjad686, English, International magazine

  • ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討
    上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese

  • コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例
    横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese

  • ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討
    上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese

  • コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例
    横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese

  • 日本におけるHPV関連頭頸部癌の疾病負担評価(THE BROADEN STUDY)
    折舘 伸彦, 齊藤 祐毅, 丹生 健一, Morais Edith, Chen Ya-Ting, Spitzer Jacqueline C., 佐藤 佳代, 齋藤 純理, 田崎 一郎
    (一社)日本癌治療学会, Oct. 2023, 日本癌治療学会学術集会抄録集, 61回, FR5 - 1, English

  • 横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese

  • ミトコンドリア病母体から出生した児の臨床症状に関する検討
    上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese

  • 放射線誘発前庭障害をきたした外耳道癌症例
    横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese

  • ミトコンドリア病母体から出生した児の臨床症状に関する検討
    上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese

  • Yutaro Koide, Takeshi Kodaira, Megumi Kitayama, Daisuke Kawakita, Tadaaki Kirita, Seiichi Yoshimoto, Munenaga Nakamizo, Ken-Ichi Nibu
    Abstract Objective This study aimed to analyze the nationwide prognosis of patients with nasopharyngeal carcinoma who underwent definitive radiotherapy in Japan, utilizing the National Head and Neck Cancer Registry data. Methods A total of 741 patients diagnosed with primary nasopharyngeal carcinoma were screened from 2011 to 2014. The inclusion criteria were histologically proven nasopharyngeal squamous cell carcinoma, receiving definitive radiotherapy, and no distant metastases. Patients with unclear prognoses or unknown staging were excluded. The primary endpoint was 5-year overall survival, and secondary endpoints were 5-year progression-free survival and survival by stage. Results A total of 457 patients met the inclusion criteria. The median age was 60 years, and 80% were male. The proportions of patients with performance status 0, 1, 2 and 3 were 69, 10, 1 and 1%, respectively. Chemoradiotherapy was administered to 84.7%. Radiotherapy modalities were recorded only for 29 patients (three received intensity-modulated radiotherapy and 26 received two/three-dimensional radiotherapy). Of those included, 7.4, 24.7, 35.7, 24.5 and 7.7% had Stage I, II, III, IVA and IVB disease, respectively. The 5-year overall survival was 72.5% for all patients: 82.6, 86.6, 76.0, 51.4 and 66.5% for Stage I, II, III, IVA and IVB disease, respectively. The 5-year progression-free survival was 58.6%: 75.6, 66.8, 61.5, 43.7 and 46.5% for Stage I, II, III, IVA and IVB disease, respectively. Conclusions This nationwide survey demonstrated favorable prognoses and provided valuable foundational data for similar future surveys to monitor the penetration of appropriate treatment and changes in clinical structures based on new evidence.
    Oxford University Press (OUP), Oct. 2023, Japanese Journal of Clinical Oncology
    Scientific journal

  • Corrigendum: Influences of Orogastric and Nasogastric Tubes on Sucking Pressure during Bottle Feeding in Immature Infants.
    Takeshi Komatsu, Tatsuya Furukawa, Daisuke Kobayashi, Sota Iwatani, Seiji Yoshimoto, Toshihiko Yamashita, Yumi Endo, Sayaka Katsunuma, Masahide Otsu, Ken-Ichi Nibu
    This corrects the article in Kobe J Med Sci. 2023 May 31; 69(1): E25-E32.
    Sep. 2023, The Kobe journal of medical sciences, 69(1) (1), S1, English, Domestic magazine

  • 岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese

  • 高齢者における人工内耳の装用効果
    岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese

  • Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.
    Jul. 2023, Head & neck, English, International magazine
    Scientific journal

  • Hikari Shimoda, Masanori Teshima, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Ken-Ichi Taguchi, Hidetaka Yamamoto, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Daisuke Kawakita, Kazuo Sakurai, Nobuhiro Hanai, Toru Nagao, Ryo Kawata, Naohito Hato, Ken-Ichi Nibu, Hiroshi Inagaki
    Adenoid cystic carcinoma (AdCC) of salivary gland grows relatively slowly, but occasionally develops distant metastasis. Although cervical lymph node metastasis (LNM) has been reported as a strong prognostic factor, most of AdCC do not have LNM. In this study, we investigated the prognostic factors to predict disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) for 175 patients surgically treated for AdCC without LNM, and developed prognostic score (PS) determined as number of positive prognostic factors. The following emerged as significant prognostic factors: positive surgical margin in DFS, pT3/4 and positive surgical margin in DMFS, and positive surgical margin and high-histological grade in OS. 10-year DFS rates were 56.4% in PS0, and 19.1% in PS1 (p < 0.0001). 10-year DMFS rates were 86.3% in PS0, 56.4% in PS1, and 30.7% in PS2 (p < 0.0001). 10-year OS rates were 100% in PS0, 73.3% in PS1, and 38.8% in PS2 (p < 0.0001).
    Jul. 2023, Oral oncology, 145, 106491 - 106491, English, International magazine

  • Akihiro Homma, Mizuo Ando, Nobuhiro Hanai, Hiroyuki Harada, Yoshitaka Honma, Tomonori Kanda, Satoshi Kano, Daisuke Kawakita, Naomi Kiyota, Yoshiyuki Kizawa, Masahiro Nakagawa, Takenori Ogawa, Hirotaka Shinomiya, Takeshi Shinozaki, Motoyuki Suzuki, Tetsuya Tsuji, Koichi Yasuda, Sadamoto Zenda, Takeshi Kodaira, Tadaaki Kirita, Ken-Ichi Nibu
    The aim of the "Japanese Clinical Practice Guidelines for Head and Neck Cancer - 2022 Update" is to review the latest evidence regarding head and neck cancer and to present the current standard approaches for diagnosis and treatment. These evidence-based recommendations were created with the consensus of the Guideline Committee, which is composed of otorhinolaryngologists and head and neck surgeons, together with radiologists, radiation oncologists, medical oncologists, plastic surgeons, dentists, palliative care physicians, and rehabilitation physicians. These guidelines were created by the Clinical Practice Guideline Committee of the Japan Society for Head and Neck Cancer based on the "Head and Neck Cancer Treatment Guidelines 2018 Edition," and the revised draft was compiled after evaluation by the Assessment Committee and public comments. The 'Clinical questions and recommendations' section consists of 13 categories, and 59 clinical questions are described in total. Here we describe 6 clinical questions specific to other sets of guidelines with recommendations and comments.
    Jul. 2023, Auris, nasus, larynx, English, International magazine
    Scientific journal

  • Akinobu Kakigi, Naoya Egami, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Kento Koda, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba
    OBJECTIVE: To investigate the isosorbide-induced dehydration effect on the endolymphatic space by intratympanic administration of isosorbide. BACKGROUND: Isosorbide, an osmotic diuretic, is used orally as a typical conservative therapy for Menière's disease (MD) in Japan. The dehydration effect occurs 6 hours after isosorbide ingestion. Intratympanic administration of isosorbide resolves endolymphatic hydrops faster than oral ingestion. In addition, the dehydration effect has never been shown directly. Therefore, we investigated the dehydration effect of intratympanic administration of isosorbide on endolymphatic hydrops using optical coherence tomography. METHODS: We used eight Hartley guinea pigs, divided into normal and hydrops groups. In the hydrops group, the animals underwent endolymphatic sac obliteration to create endolymphatic hydrops. We obtained midmodiolar section images of the cochleae using optical coherence tomography. Then, 50 to 70% isosorbide was sequentially administered intratympanically for 5 minutes, and the apical turn of the cochlea was observed. The relative midmodiolar cross-sectional area of the scala media was calculated for quantitative assessment of the endolymphatic space. RESULTS: In the normal group, 50% isosorbide had a slight but significant dehydration effect on the scala media; at 55 to 70%, Reissner's membrane became flat. In the hydrops group, 50% isosorbide slightly reduced endolymphatic hydrops; 65% flattened Reissner's membrane, and 70% slightly concaved it toward the basilar membrane. CONCLUSION: The results suggest that we could select the concentration of isosorbide according to the stage or severity of MD and relief from acute attack. Intratympanic administration of isosorbide may be a promising treatment for patients with MD.
    Jul. 2023, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, English, International magazine
    Scientific journal

  • Kaori Ueda, Takayuki Murase, Daisuke Kawakita, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Hidetaka Yamamoto, Ken-Ichi Taguchi, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Kazuo Sakurai, Nobuhiro Hanai, Toru Nagao, Ryo Kawata, Naohito Hato, Ken-Ichi Nibu, Hiroshi Inagaki
    Approximately 60% of adenoid cystic carcinoma (AdCC) cases are positive for MYB::NFIB or MYBL1::NFIB, whereas MYB/MYBL1 oncoprotein, a key driver of AdCC, is overexpressed in most cases. Juxtaposition of superenhancer regions in NFIB and other genes into the MYB/MYBL1 locus is an attractive oncogenic hypothesis for AdCC cases, either negative or positive for MYB/MYBL1::NFIB. However, evidence supporting this hypothesis is insufficient. We examined 160 salivary AdCC cases for rearrangements in MYB/MYBL1 loci and peri-MYB/MYBL1 areas (centromeric and telomeric areas of 10 Mb each) using formalin-fixed, paraffin-embedded tumor sections. For the detection of the rearrangements, we employed conventional fluorescence in situ hybridization split and fusion assays and a 5 Mb fluorescence in situ hybridization split assay. The latter is a novel assay that enabled us to detect any possible splits within a 5 Mb distance of a chromosome. We found MYB/MYBL1- and peri-MYB/MYBL1-associated rearrangements in 149/160 patients (93%). AdCC cases positive for rearrangements in MYB, MYBL1, the peri-MYB area, and the peri-MYBL1 area numbered 105 (66%), 20 (13%), 19 (12%), and 5 (3%), respectively. In 24 peri-MYB/MYBL1 rearrangement-positive cases, 14 (58%) were found to have a juxtaposition of the NFIB or RAD51B locus into the MYB/MYBL1 loci. On comparing with a tumor group positive for MYB::NFIB, a hallmark of AdCC, other genetically classified tumor groups had similar features of overexpression of the MYB transcript and MYB oncoprotein as detected by semiquantitative RT-qPCR and immunohistochemistry, respectively. In addition, clinicopathological and prognostic features were similar among these groups. Our study suggests that peri-MYB/MYBL1 rearrangements may be a frequent event in AdCC and may result in biological and clinicopathological consequences comparable to MYB/MYBL1 rearrangements. The landscape of MYB/MYBL1 and peri-MYB/MYBL1 rearrangements shown here strongly suggests that juxtaposition of superenhancers into MYB/MYBL1 or peri-MYB/MYBL1 loci is an alteration that acts as a key driver for AdCC oncogenesis and may unify MYB/MYBL1 rearrangement-positive and negative cases.
    Jul. 2023, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 36(10) (10), 100274 - 100274, English, International magazine
    Scientific journal

  • 腫瘍茎部が消失していた外耳道骨腫の1例
    中居 薫花, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 66 - 66, Japanese

  • 人工内耳装用により認知機能検査のスコアが改善した高齢者の1例
    上坂 紗貴子, 岩城 忍, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 139 - 139, Japanese

  • Yuiko Hashimoto, Masanori Teshima, Mitsuko Yui, Shun Tatehara, Keisuke Iritani, Tatsuya Furukawa, Hirotaka Shinomiya, Ken-Ichi Nibu
    Chylous leakage is a rare but serious postoperative complication of neck dissection (ND). Most chylous leakages are successfully treated either by drainage or ligation of the thoracic duct, but the resolution is occasionally prolonged. OK432 sclerotherapy is used to treat various refractory cystic diseases of the head and neck. Three patients were treated with OK432 sclerotherapy for refractory chylous leakage following ND. Case 1 involved a 77-year-old man with chylous leakage after a total laryngectomy and bilateral ND. Case 2 involved a 71-year-old woman who underwent total thyroidectomy and left ND for thyroid cancer. Case 3 involved a 61-year-old woman who underwent right ND for oropharyngeal cancer. In all patients, chylous leakage rapidly improved after OK432 injection without any complications. Our results suggest the efficacy of OK432 sclerotherapy in patients with refractory chylous leakage after ND.
    Jun. 2023, Journal of surgical case reports, 2023(6) (6), rjad310, English, International magazine

  • Influences of Orogastric and Nasogastric Tubes on Sucking Pressure during Bottle Feeding in Immature Infants.
    Takeshi Komatsu, Tatsuya Furukawa, Daisuke Kobayashi, Sota Iwatani, Seiji Yoshimoto, Toshihiko Yamashita, Yumi Endo, Sayaka Katsunuma, Masahide Otsu, Ken-Ichi Nibu
    Orogastric (OG) and nasogastric (NG) tubes have been reported to delay breastfeeding initiation and affect respiratory function. However, the effects of feeding tubes on sucking pressure have not been well studied. Fourteen preterm infants were enrolled in this study, and their sucking pressures during bottle feeding with an OG tube, NG tube, and without any tube were measured. Sucking pressure significantly increased after changing the OG tube to an NG tube (p = 0.044). However, sucking pressure showed no significant differences after changing the feeding method from an NG tube to oral intake. Thus, NG tubes are superior to OG tubes in terms of sucking pressure.
    May 2023, The Kobe journal of medical sciences, 69(1) (1), E25-E32, English, Domestic magazine
    Scientific journal

  • Kotaro Tamagawa, Naoki Otsuki, Hikari Shimoda, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu
    OBJECTIVES: To clarify the indication of neck dissection (ND) for patient with submandibular gland (SMG) cancer. METHODS: A total of 43 patients with SMG cancer were retrospectively analyzed. Forty-one patients underwent ND: Levels I-V in 19 patients, Levels I-III in 18 patients, and Level Ib in 4 patients. The other two patients did not undergo ND, since preoperative diagnoses were benign. Postoperative radiotherapy was performed in 19 patients with positive surgical margin, high grade cancer or stage IV disease. RESULTS: LN metastases were pathologically confirmed in all patients with cN + and 6 out of 31 patients with cN-. No patients developed regional recurrence during follow-up periods. Ultimately, LN metastases were pathologically confirmed in 17 of 27 high grade, one out of 9 intermediate grade, but not in 7 low grade. CONCLUSIONS: Prophylactic neck dissection should be considered in T3/4 and high grade SMG cancers.
    May 2023, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, English, International magazine
    Scientific journal

  • 上田 佳緒璃, 村瀬 貴幸, 川北 大介, 長尾 俊孝, 草深 公秀, 中黒 匡人, 浦野 誠, 山元 英崇, 田口 健一, 加納 里志, 多田 雄一郎, 塚原 清彰, 大上 研二, 鬼塚 哲郎, 藤本 保志, 櫻井 一生, 花井 信広, 長尾 徹, 河田 了, 羽藤 直人, 丹生 健一, 稲垣 宏
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 193 - 193, Japanese

  • Kotaro Tamagawa, Hirotaka Shinomiya, Takuya Okada, Shun Tatehara, Masanori Teshima, Ryohei Sasaki, Ken-Ichi Nibu
    BACKGROUND: Superselective cisplatin (CDDP) infusion via the external carotid artery system and concomitant radiotherapy (RADPLAT) provides favorable oncological and functional outcomes in patients with maxillary sinus cancer. However, targeted lesions are occasionally fed by the branch of the internal carotid artery. METHODS: In RADPLAT for maxillary sinus cancer partly fed by the ophthalmic artery, the ethmoid arteries were ligated in two patients without medial orbital wall involvement. In four patients with that, CDDP was administered via the ophthalmic artery. RESULTS: A complete response was obtained in all six patients. Locoregional recurrence was not observed in any cases. However, visual acuity was lost in four patients who received the ophthalmic artery infusion. CONCLUSIONS: Ligation of the ethmoid arteries is recommended in RADPLAT for maxillary sinus cancer with lesions fed by the ophthalmic artery. CDDP administered via the ophthalmic artery may be considered if a patient accepts the possibility of visual loss.
    May 2023, Head & neck, 45(5) (5), E16-E24, English, International magazine

  • 日本におけるHPV関連頭頸部癌の疾病負担評価(The BROADEN study)
    齊藤 祐毅, 佐藤 佳代, 齋藤 純理, 折舘 伸彦, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 130 - 130, Japanese

  • 当院における甲状腺がんに対するがん遺伝子パネル検査の現状と課題
    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 下田 光, 手島 直則, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 132 - 132, Japanese

  • 当科における下咽頭癌T3症例の検討
    由井 光子, 松野 祐久, 入谷 啓介, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 147 - 147, Japanese

  • 進行頭頸部扁平上皮がん患者における静脈血栓塞栓症 前向き観察研究サブ解析
    今村 善宣, 小山 泰司, 長谷 善明, 手島 直則, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一, 清田 尚臣
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 152 - 152, Japanese

  • 唾液腺腺様嚢胞癌cN0/pN0症例における予後スコアの作成
    下田 光, 手島 直則, 村瀬 貴幸, 長尾 俊孝, 草深 公秀, 中黒 匡人, 浦野 誠, 田口 健一, 山元 英崇, 加納 里志, 多田 雄一郎, 塚原 清彰, 大上 研二, 鬼塚 哲郎, 藤本 保志, 川北 大介, 櫻井 一生, 花井 信広, 長尾 徹, 河田 了, 羽藤 直人, 丹生 健一, 稲垣 宏
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 193 - 193, Japanese

  • 当科における頭頸部癌治療後の開口障害について
    高橋 美貴, 岩城 忍, 西岡 仁美, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 221 - 221, Japanese

  • 進行甲状腺癌に対する手術を含む集学的治療 局所進行・再発甲状腺癌に対する当科の外科的アプローチ
    手島 直則, 三根 実穂子, 藤原 肇, 下田 光, 丹生 健一
    (一社)日本内分泌外科学会, May 2023, 日本内分泌外科学会雑誌, 40(Suppl.1) (Suppl.1), S104 - S104, Japanese

  • ビッグデータが拓く頭頸部がんのリアルワールド 頭頸部悪性腫瘍全国登録を活用した上咽頭癌放射線治療症例の予後調査研究
    小出 雄太郎, 橋本 眞吾, 立花 弘之, 古平 毅, 北山 恵, 川北 大介, 桐田 忠昭, 吉本 世一, 丹生 健一
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 59 - 59, Japanese

  • 唾液腺腺様嚢胞癌cN0/pN0症例における予後スコアの作成
    下田 光, 手島 直則, 村瀬 貴幸, 長尾 俊孝, 草深 公秀, 中黒 匡人, 浦野 誠, 田口 健一, 山元 英崇, 加納 里志, 多田 雄一郎, 塚原 清彰, 大上 研二, 鬼塚 哲郎, 藤本 保志, 川北 大介, 櫻井 一生, 花井 信広, 長尾 徹, 河田 了, 羽藤 直人, 丹生 健一, 稲垣 宏
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 193 - 193, Japanese

  • 唾液腺腺様嚢胞癌におけるMYB/MYBL1遺伝子関連異常の検索
    上田 佳緒璃, 村瀬 貴幸, 川北 大介, 長尾 俊孝, 草深 公秀, 中黒 匡人, 浦野 誠, 山元 英崇, 田口 健一, 加納 里志, 多田 雄一郎, 塚原 清彰, 大上 研二, 鬼塚 哲郎, 藤本 保志, 櫻井 一生, 花井 信広, 長尾 徹, 河田 了, 羽藤 直人, 丹生 健一, 稲垣 宏
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 193 - 193, Japanese

  • 進行涙腺癌に対する眼窩内容及び眼窩上外側骨一塊切除後前頭蓋底再建手術 機能と整容に対する配慮
    上田 美怜, 野村 正, 四宮 弘隆, 丹生 健一, 木村 英仁, 榊原 俊介, 寺師 浩人
    (一社)日本頭頸部癌学会, May 2023, 頭頸部癌, 49(2) (2), 196 - 196, Japanese

  • 櫻井 結華, 藤田 岳, 森田 由香, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese

  • 藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese

  • 副島 康平, 土井 健史, 西岡 祐希, 田根 慎也, 法華 大助, 田中 雄悟, 眞庭 謙昌, 手島 直則, 丹生 健一
    (NPO)日本気管食道科学会, Apr. 2023, 日本気管食道科学会会報, 74(2) (2), s28 - s28, Japanese

  • 甲状腺乳頭癌に合併した抗NMDAR抗体脳炎の1例
    三根 実穂子, 藤原 肇, 下田 光, 手島 直則, 関口 兼司, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 596 - 596, Japanese

  • 藤田 岳, 上原 奈津美, 山下 俊彦, 西川 敦, 河合 俊和, 鈴木 寿, 横井 純, 柿木 章伸, 丹生 健一
    頭頸部外科領域にロボット手術が保険適応となり, 耳鼻咽喉科医にとってもロボット手術は身近な存在となってきた. しかし泌尿器・消化器領域で発展してきた手術ロボットを, そのまま耳や鼻の手術に応用することはまだ難しい. 私達は経外耳道的内視鏡下耳科手術 (Trans-canal Endoscopic Ear Surgery: TEES) を支援するロボットの研究・開発を複数の大学の工学部と共同で行っている. 手術ロボットの研究を通して, 自分たちの手術の特徴や問題点を改めて見直す機会が得られている. 本稿では, これまでの耳科手術用ロボットや内視鏡保持ロボットについて概略を述べ, 現在研究中の TEES 支援ロボットのコンセプトと試作機について述べる. また, 将来ロボット自身が自律的に手術を行うことを目標とした, ロボットの自律レベル向上に向けた研究についても紹介する.
    日本耳鼻咽喉科頭頸部外科学会, Mar. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(3) (3), 181 - 184, Japanese, Domestic magazine
    Symposium

  • 川北 大介, 猪原 秀典, 折舘 伸彦, 守本 倫子, 丹生 健一
    日本臨床ウイルス学会, Mar. 2023, 臨床とウイルス, 51(1) (1), 16 - 21, Japanese

  • Yuki Saito, Seiichi Yoshimoto, Megumi Kitayama, Takaaki Hayashi, Koji Yamamura, Kenya Kobayashi, Osamu Fukuoka, Ken-Ichi Nibu, Tatsuya Yamasoba
    BACKGROUND: Although total laryngectomy is the standard treatment for advanced laryngeal cancer, the significance of elective neck dissection (END) for N0 laryngeal cancer remains unclear in Japan, which is an aging society. METHODS: We conducted a retrospective nationwide observational study on patients with T3-T4N0 laryngeal squamous cell carcinoma treated with curative total laryngectomy from 2011 to 2018 in Japan. RESULTS: A total of 1,218 patients were analyzed. The median patient age was 72 years, with 735 cases of T3N0 and 483 cases of T4N0. END was performed on the affected side in 850 patients (70%) and on the contralateral side in 502 patients (41.2%). END on the affected side was omitted in patients aged > 80 years (40.4%) and in patients with an advanced performance status. The occult lymph-node metastasis rate did not differ by age (18.8%-19.6%); it tended to increase chronologically from 2011 (11.1%) and was higher in cT4a (22.5%) and pT4a (24.3%) cases. In this study, coherent clinical information and follow-up data were available for 252 patients. Both univariate and multivariate analyses showed no significant prognostic factors for overall survival or recurrence-free survival for either affected or contralateral END. Older age and subglottic location were poor prognostic factors, but death due to factors other than laryngeal cancer could not be ignored in older patients. CONCLUSION: Omission of END during laryngectomy for T3-T4N0 laryngeal cancer is acceptable for older patients who want their operation to be completed in a short time.
    Feb. 2023, International journal of clinical oncology, 28(2) (2), 209 - 220, English, Domestic magazine
    Scientific journal

  • Jun Yokoi, Takeshi Fujita, Natsumi Uehara, Shinobu Iwaki, Akinobu Kakigi, Ken-Ichi Nibu
    INTRODUCTION: Binaural hearing enhances speech intelligibility, source localization, and speech comprehension in noisy environments. Although bilateral cochlear implantation (CI) offers several benefits, concerns arise regarding the risk of bilateral postoperative vestibular dysfunction with simultaneous CI. This study aimed to longitudinally evaluate changes in vestibular function in adult patients who underwent simultaneous bilateral CI using minimally invasive electrodes and surgical techniques. METHODS: A retrospective review was conducted on 10 patients who underwent simultaneous bilateral CI at our hospital. Vertigo symptoms and vestibular function test results were examined preoperatively, 1-6 months postoperatively, and 1 year postoperatively. Nystagmus tests, caloric reflex tests, vestibular evoked myogenic potentials (VEMP) measurements, and static stabilometry were performed as vestibular function tests. RESULTS: Although an initial transient decline in vestibular function was observed, no significant long-term decline was observed in the caloric reflex test, ocular VEMP (oVEMP), or cervical VEMP (cVEMP). Moreover, regardless of the presence or absence of abnormalities in caloric reflex, oVEMP, or cVEMP, no significant deterioration was detected in the static stabilometer test. While two patients reported preoperative dizziness, all patients were symptom-free 1 year postoperatively. DISCUSSION: The findings suggest that using current minimally invasive electrodes and surgical techniques in simultaneous bilateral CI leads to temporary vestibular function decline postoperatively. However, most patients experience a recovery in function over time, highlighting the potential safety and efficacy of the procedure. Simultaneous bilateral CI surgery is viable, depending on the patient's auditory needs and burden.
    2023, Frontiers in neurology, 14, 1304927 - 1304927, English, International magazine
    Scientific journal

  • Go Omura, Seiichi Yoshimoto, Ryoko Rikitake, Kohtaro Eguchi, Munenaga Nakamizo, Ken-Ichi Nibu
    BACKGROUND: This study aimed to evaluate the prognostic outcome for adolescent and young adult (AYA) generation patients with tongue squamous cell carcinoma (TSCC). METHODS: Data were obtained from the Head and Neck Cancer Registry of Japan, and patients who were newly diagnosed with TSCC from 2011 to 2014 were extracted. We compared the clinical parameter and survival of the ≤ 39 years old (AYA) patient group with the 40-79 (non-AYA) group. Propensity score matching (PSM) was used for survival analyses. RESULTS: Our cohort included 2221 patients with TSCC. AYA and non-AYA groups consisted of 258 and 1963 patients, respectively. The AYA group has a larger proportion of females than the non-AYA group (P < 0.001). Following PSM, both overall and disease-specific survival of the AYA group was significantly longer than those of the non-AYA group (P = 0.009 and P = 0.04, respectively). CONCLUSION: We demonstrated the survival superiority of AYA patients with TSCC compared to older adult patients. Therefore, our study results may reduce this anxiety by providing patients with appropriate information of prognosis for AYA patients with TSCC.
    Dec. 2022, International journal of clinical oncology, English, Domestic magazine
    Scientific journal

  • Sayaka Katsunuma, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu
    In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species. The cell adhesion molecules nectin-1 and nectin-3 are required for this pattern formation. The checkerboard-like pattern is thought to be necessary for auditory function, but has never been examined. Here, we showed the significance of checkerboard-like cellular pattern in the survival and function of sensory hair cells in the cochlear auditory epithelia of nectin-3 knockout (KO) mice. Nectin-3 KO mice showed progressive hearing loss associated with degeneration of aberrantly attached hair cells via apoptosis. Apoptotic hair cell death was due to the disorganization of tight junctions between the hair cells. Our study revealed that the checkerboard-like cellular pattern in the auditory epithelium provides a structural basis for ensuring the survival of cochlear hair cells and hearing function.
    Frontiers Media SA, Dec. 2022, Frontiers in Cell and Developmental Biology, 10
    Scientific journal

  • 有吉 偉雄, 古川 竜也, 四宮 弘隆, 入谷 啓介, 蓼原 瞬, 丹生 健一
    (株)医学書院, Nov. 2022, 耳鼻咽喉科・頭頸部外科, 94(12) (12), 1055 - 1058, Japanese

  • 横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2022, Equilibrium Research, 81(5) (5), 469 - 469, Japanese

  • 遅発性感音難聴患者における聴力型から見た遺伝学的背景の検討
    上原 奈津美, 藤田 岳, 横井 純, 西尾 信哉, 宇佐美 真一, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 138 - 138, Japanese

  • ミトコンドリアDNA7445A>G変異による難聴及び掌蹠角化症を認めた2例
    稲田 幸歩, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 170 - 170, Japanese

  • 中耳髄膜腫の一例
    庄司 夢, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 309 - 309, Japanese

  • 経外耳道的内視鏡下手術(TEES)で摘出し得たグロムス腫瘍症例
    小西池 佑一, 藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 310 - 310, Japanese

  • 手術とデノスマブによるアジュバント療法を施行した側頭骨骨巨細胞腫の1例
    横井 純, 柿木 章伸, 上原 奈津美, 藤田 岳, 丹生 健一
    (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 393 - 393, Japanese

  • 成人における両側人工内耳手術の適応に関する検討(第一報)
    岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2022, Audiology Japan, 65(5) (5), 430 - 430, Japanese

  • Tatsuya Furukawa, Shun Tatehara, Masanori Teshima, Hirotaka Shinomiya, Go Inokuchi, Masato Komatsu, Shigeo Hara, Yoh Zen, Ken-Ichi Nibu
    OBJECTIVE: Olfactory neuroblastoma (ONB) is often difficult to pathologically distinguish from other small round cell tumors (SRCTs) arising in the nasal cavities. Although there are several diagnostic markers used for differential diagnosis of ONB, these molecules are also expressed in various neuronal derived tumors. Here, we examined the expression of NeuroD, GAP43, and olfactory marker protein (OMP) in ONB and non-ONB SRCT to determine their utility in the differential diagnosis of ONB. METHODS: Twenty-six patients diagnosed with and treated for ONB at Kobe University Hospital between 1997 and 2017 with formalin-fixed, paraffin-embedded biopsy or surgical resection specimens were included. The expressions of NeuroD, GAP43, and OMP were immunohistochemically examined in these 26 ONB specimens and specimens from 13 SRCTs arising in the nasal cavities for reference. RESULTS: Among the 26 ONB samples, focal, patchy, and marked staining for NeuroD was observed in 4, 3, and 9 samples, respectively. Focal, patchy, and marked GAP43 staining was observed in 5, 3, and 11 samples, respectively. Consequently, marked positive staining for either NeuroD or GAP43 was observed in 54% (14/26) of ONBs. Among the 13 SRCTs, marked staining for NeuroD was observed in two small cell carcinomas, one undifferentiated carcinoma, and one neuroendocrine carcinoma, whereas marked positive staining for GAP43 was observed only in one undifferentiated carcinoma. No specimen in this study exhibited OMP staining. CONCLUSIONS: Our results suggest possible roles of GAP43 immunostaining in the differential diagnosis of ONB.
    Aug. 2022, Auris, nasus, larynx, English, International magazine
    Scientific journal

  • 唾液腺癌診療の現状と治療戦略
    手島 直則, 藤原 肇, 下田 光, 丹生 健一
    日本口腔・咽頭科学会, Aug. 2022, 口腔・咽頭科, 35(3) (3), 195 - 195, Japanese

  • 高橋 雅之, 清水 昭一朗, 蓼原 瞬, 手島 直則, 由井 光子, 小松 正人, 井之口 豪, 丹生 健一
    (株)医学書院, Aug. 2022, 耳鼻咽喉科・頭頸部外科, 94(9) (9), 763 - 768, Japanese

  • Keisuke Iritani, Masanori Teshima, Hikari Shimoda, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu
    OBJECTIVE: We investigated the factors affecting postoperative parathyroid gland (PTG) function and devised an objective index to predict the postoperative PTG function during total thyroidectomy. METHOD: This was a retrospective clinical review of 21 consecutive patients who were diagnosed with papillary thyroid carcinoma and underwent total thyroidectomy. The maximum intensity ratio (MIR) was determined as the maximum fluorescence intensity after ICG injection divided by the intensity before ICG injection. RESULTS: Postoperative hypoparathyroidism is significantly associated with simultaneous central neck dissection (CND) and lateral neck dissection (LND) (p = .032). The Spearman correlation test showed a moderate correlation between the MIR and iPTH levels (p = .0047). The optimal MIR cutoff value for predicting postoperative hypoparathyroidism was 2.14 with area under the curve = 0.904 (sensitivity: 0.769 and specificity: 1.00). CONCLUSION: CND + LND was significantly associated with postoperative hypoparathyroidism. MIR was found useful in predicting the postoperative PTG function.
    Aug. 2022, Laryngoscope investigative otolaryngology, 7(4) (4), 1251 - 1258, English, International magazine
    Scientific journal

  • 視覚聴覚二重障害を持つ小児の診療における遺伝学的検査の意義
    松永 達雄, 奈良 清光, 務台 英樹, 泉 修司, 山岸 達矢, 堀井 新, 江崎 友子, 土橋 奈々, 中川 尚志, 上原 奈津美, 丹生 健一, 山本 修子, 和佐野 浩一郎, 南 修司郎, 加我 君孝
    日本小児耳鼻咽喉科学会, Jun. 2022, 小児耳鼻咽喉科, 43(2) (2), 157 - 157, Japanese

  • Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu
    OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.
    Jun. 2022, Auris, nasus, larynx, 49(3) (3), 477 - 483, English, International magazine
    Scientific journal

  • 小山 泰司, 清田 尚臣, 今村 善宣, 土井 久容, 丹田 雅明, 四宮 弘隆, 宮脇 大輔, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 182 - 182, Japanese

  • 進行聴器癌35例に対するDocetaxel、Cisplatin、5-FU同時併用化学放射線治療の検討
    山田 晃大, 四宮 弘隆, 手島 直則, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 152 - 152, Japanese

  • 唾液腺癌の各病理組織型におけるEGFR発現率の検討
    藤原 肇, 丹生 健一, 四宮 弘隆, 手島 直則, 下田 光
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 157 - 157, Japanese

  • 当科における喉頭全摘術後の気管孔狭窄症例の臨床的観察と介入
    高橋 美貴, 岩城 忍, 入谷 啓介, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 187 - 187, Japanese

  • 耳下部腫瘤を唯一の症状とした慢性活動性EBウィルス感染症(CAEBV)の1例
    下田 光, 手島 直則, 藤原 肇, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 230 - 230, Japanese

  • 手島 直則, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2022, 日本耳鼻咽喉科頭頸部外科学会会報, 125(4) (4), 591 - 591, Japanese

  • 山田 晃大, 四宮 弘隆, 手島 直則, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2022, 日本耳鼻咽喉科頭頸部外科学会会報, 125(4) (4), 698 - 698, Japanese

  • 入谷 啓介, 藤原 肇, 下田 光, 手島 直則, 四宮 弘隆, 大月 直樹, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2022, 日本耳鼻咽喉科頭頸部外科学会会報, 125(4) (4), 716 - 716, Japanese

  • Natsumi Uehara, Takeshi Fujita, Daisuke Yamashita, Jun Yokoi, Sayaka Katsunuma, Akinobu Kakigi, Shin-Ya Nishio, Ken-Ichi Nibu, Shin-Ichi Usami
    Genetic testing for congenital or early-onset hearing loss patients has become a common diagnostic option in many countries. On the other hand, there are few late-onset hearing loss patients receiving genetic testing, as late-onset hearing loss is believed to be a complex disorder and the diagnostic rate for genetic testing in late-onset patients is lower than that for the congenital cases. To date, the etiology of late-onset hearing loss is largely unknown. In the present study, we recruited 48 unrelated Japanese patients with late-onset bilateral sensorineural hearing loss, and performed genetic analysis of 63 known deafness gene using massively parallel DNA sequencing. As a result, we identified 25 possibly causative variants in 29 patients (60.4%). The present results clearly indicated that various genes are involved in late-onset hearing loss and a significant portion of cases of late-onset hearing loss is due to genetic causes. In addition, we identified two interesting cases for whom we could expand the phenotypic description. One case with a novel MYO7A variant showed a milder phenotype with progressive hearing loss and late-onset retinitis pigmentosa. The other case presented with Stickler syndrome with a mild phenotype caused by a homozygous frameshift COL9A3 variant. In conclusion, comprehensive genetic testing for late-onset hearing loss patients is necessary to obtain accurate diagnosis and to provide more appropriate treatment for these patients.
    Apr. 2022, Journal of human genetics, 67(4) (4), 223 - 230, English, International magazine
    Scientific journal

  • 横井 純, 丹生 健一
    (株)東京医学社, Mar. 2022, JOHNS, 38(3) (3), 303 - 306, Japanese

  • Satsuki Nakano, Yoshihide Okumura, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Satoshi Kano, Kiyoaki Tsukahara, Kenji Okami, Daisuke Kawakita, Toru Nagao, Nobuhiro Hanai, Hiroshi Iwai, Ryo Kawata, Yuichiro Tada, Ken-Ichi Nibu, Hiroshi Inagaki
    AIMS: To investigate the histological diversity of salivary mucoepidermoid carcinoma (MEC), its clinicopathological features, and its associations with CRTC1/3-MAML2 fusions. METHODS AND RESULTS: Salivary MEC cases (n = 177) were examined for CRTC1/3-MAML2 fusions, histological variants were classified, and tumours were graded according to four different grading systems. Adverse histological features considered to be unusual in MEC were also investigated. Of the 177 MEC cases, 110 were positive for CRTC1/3-MAML2 fusions. The classical variant was the most frequent in the fusion-positive case group, the fusion-negative case group, and the total case group. The clear/oncocytic variant was the second most frequent in the fusion-positive and total case groups. Oncocytic, Warthin-like and spindle variants were seen in the fusion-positive case group only. Clear cell, sclerosing, mucinous and central variants were seen in both the fusion-positive case group and the fusion-negative case group. No case was classified as a ciliated variant, as a mucoacinar variant, or as a high-grade transformation. As compared with the classical variant, non-classical variants were characterised by frequent CRTC1/3-MAML2 fusions and a low clinical stage in all cases. Of the four histological features considered to be unusual in MEC, marked nuclear atypia, frequent mitoses (>10/10 high-power fields) and extensive necrosis were found independently of the fusion status, and were present in 3-5% of all cases. However, none of the cases showed overt keratinisation. On comparison, the Armed Forces Institute of Pathology and modified Healey grading systems downgraded tumours, the Brandwein system upgraded tumours, and the Memorial Sloan Kettering system provided a moderate means of assessment. CONCLUSION: Recognition of the histological diversity of MEC, its clinicopathological features and its associations with CRTC1/3-MAML2 fusions is helpful for an accurate diagnosis of this carcinoma.
    Mar. 2022, Histopathology, 80(4) (4), 729 - 735, English, International magazine
    Scientific journal

  • cT3N0M0声門癌に対する根治的放射線治療の成績
    岩下 和真, 石原 武明, 妹尾 悟史, 窪田 光, 川口 弘毅, 小林 加奈, 宮脇 大輔, 佐々木 良平, 手島 直則, 丹生 健一, 今村 善宣, 清田 尚臣
    (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 36 - 36, Japanese

  • Ayaka Shibano, Hidehito Kimura, Shun Tatehara, Tatsuya Furukawa, Kazuki Inoue, Yuichi Fujita, Hiroaki Nagashima, Shunsuke Yamanishi, Tadashi Nomura, Ken-Ichi Nibu, Takashi Sasayama
    Owing to recent advances in medical optical technology, a high-definition (4K) three-dimensional (3D) exoscope has been developed as an alternative tool to using conventional microscopes for microscopic surgery, and its efficacy for neurosurgery has been reported. We report a case who underwent simultaneous surgery aiming for en bloc resection of an anterior skull base malignancy with concurrent exoscopic transcranial and endoscopic endonasal approaches using a 4K 3D exoscope. The patient was a 76-year-old woman who underwent en bloc resection for an anterior skull base olfactory neuroblastoma 13 years ago. After confirming the recurrence of progressive olfactory neuroblastoma, tumor resection was again decided to be performed. As with the first procedure, surgery was performed in an en bloc manner, using both transcranial and endonasal approaches. Exoscope provided enough space above the surgical field to allow us to perform transcranial and endonasal surgeries simultaneously. Moreover, the surgeons could maintain a comfortable posture throughout the procedure, and total tumor removal was successfully achieved without any abnormal event. To our knowledge, this is the first report of the introduction of an exoscope aiming for en bloc resection of an anterior skull base malignancy while performing simultaneous surgery with both transcranial and endonasal approaches. We believe that the more cases are accumulated, the more efficacy of a 4K 3D exoscope will be elucidated.
    2022, NMC case report journal, 9, 243 - 247, English, Domestic magazine

  • Daichi Fujii, Hikari Shimoda, Natsumi Uehara, Takeshi Fujita, Masanori Teshima, Hirotaka Shinomiya, Akinobu Kakigi, Tomoaki Terakawa, Masato Fujisawa, Ken-ichi Nibu
    Informa {UK} Limited, Dec. 2021, Acta Oto-Laryngologica Case Reports, 6(1) (1), 1 - 5
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masanori Teshima, Hirotaka Shinomiya, Hidehito Kimura, Kazunobu Hashikawa, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Eiji Kohmura, Ken-Ichi Nibu
    Purpose: To investigate the oncological outcomes of orbital malignant tumors invading the skull base. Methods: A retrospective analysis was conducted on 16 patients with orbital malignant tumors invading the skull base. Eleven patients were treated with skull base surgery, four patients were treated with particle therapies, and one patient was treated with chemoradiotherapy (CRT) as initial treatment. Results: The most frequent histological type was adenoid cystic carcinoma in seven patients, followed by squamous cell carcinoma in two patients. Local recurrence occurred in two of the six surgically treated patients who did not receive postoperative radiotherapy (RT) or CRT. One of them was successfully salvaged by RT, and the other died of disease. With a median follow-up of 24 months, the 2-year overall, local control, and disease-free survival rates of all patients were 82.5%, 87.5%, and 59%, respectively. Conclusions: Patients with positive surgical margins were at risk of local recurrence. Postoperative RT should be considered for all surgically treated patients.Level of Evidence: 4.
    Dec. 2021, Laryngoscope investigative otolaryngology, 6(6) (6), 1347 - 1352, English, International magazine
    Scientific journal

  • Yoshinori Imamura, Kaoru Tanaka, Naomi Kiyota, Hidetoshi Hayashi, Ichiro Ota, Akihito Arai, Shigemichi Iwae, Shujiro Minami, Katsunari Yane, Tomoko Yamazaki, Yoshiaki Nagatani, Masanori Toyoda, Takayuki Takahama, Kazuko Sakai, Kazuto Nishio, Naoki Otsuki, Ken-ichi Nibu, Hironobu Minami
    Springer Science and Business Media LLC, Nov. 2021, Medical Oncology, 38(11) (11)
    Scientific journal

  • 手島 直則, 丹生 健一
    (株)医学書院, Oct. 2021, 耳鼻咽喉科・頭頸部外科, 93(11) (11), 945 - 949, Japanese

  • 当科における甲状腺癌脳転移症例の検討
    下田 光, 藤原 肇, 手島 直則, 大月 直樹, 丹生 健一
    (一社)日本内分泌外科学会, Oct. 2021, 日本内分泌外科学会雑誌, 38(Suppl.2) (Suppl.2), S257 - S257, Japanese

  • 高橋 美貴, 岩城 忍, 入谷 啓介, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, Oct. 2021, 頭頸部癌, 47(3) (3), 322 - 328, Japanese

  • 横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2021, Equilibrium Research, 80(5) (5), 482 - 482, Japanese

  • 一側性聴神経腫瘍症例における蝸牛内のMRI信号強度
    藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 187 - 187, Japanese

  • 当科におけるグロムス腫瘍18例の治療方針の検討
    横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 199 - 199, Japanese

  • ミトコンドリアDNA3243A>G変異によるミトコンドリア病の1家系
    上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 265 - 265, Japanese

  • キヌタ骨が乳突洞内に脱出した外傷性耳小骨離断の1例
    遠藤 侑未, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 385 - 385, Japanese

  • Kiyoto Shiga, Ken-Ichi Nibu, Yasushi Fujimoto, Takahiro Asakage, Akihiro Homma, Hiroki Mitani, Takenori Ogawa, Kenji Okami, Shigeyuki Murono, Shigeru Hirano, Tsutomu Ueda, Nobuhiro Hanai, Kiyoaki Tsukahara, Ichiro Ota, Seiichi Yoshimoto, Takeshi Shinozaki, Shigemichi Iwae, Katsunori Katagiri, Daisuke Saito, Naomi Kiyota, Makoto Tahara, Fumiaki Takahashi, Ryuichi Hayashi
    BACKGROUND: This study aimed to reveal the influence of the invasion site of external auditory canal (EAC) cancer by analyzing the outcome of patients with advanced tumor. METHODS: A total of 111 patients with T4 EAC cancer were enrolled in this study. Of these patients, 79 underwent chemoradiotherapy and 32 underwent surgery under curative intent. Univariate and multivariate analyses and the Kaplan-Meier method were used to focus on the tumor invasion sites and overall survival of the patients. RESULTS: The 3-year overall survival rate of all patients was 55.0%. In multivariate analysis, the only significant invasion site for overall survival was the facial nerve, with the dura mater being the next most influential site. When Kaplan-Meier survival curve was calculated, facial nerve and dura mater were the significant factors resulting in poor patient outcomes. CONCLUSION: The facial nerve and dura mater are crucial sites of EAC cancer for patient outcomes.
    Oct. 2021, Head & neck, 43(10) (10), 3097 - 3105, English, International magazine
    Scientific journal

  • 遺伝性出血性毛細血管拡張症における鼻出血重症度スコアの日本語版の作成と妥当性の検討
    端山 昌樹, 前田 陽平, 識名 崇, 井之口 豪, 蓼原 瞬, 小幡 翔, 中谷 彩香, 天野 雄太, 丹生 健一, 猪原 秀典
    (一社)日本鼻科学会, Sep. 2021, 日本鼻科学会会誌, 60(3) (3), 365 - 365, Japanese

  • 岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2021, Audiology Japan, 64(5) (5), 466 - 466, Japanese

  • Makoto Tahara, Naomi Kiyota, Ken-Ichi Nibu, Ayumi Akamatsu, Tomohiro Hoshino, Ryuichi Hayashi
    BACKGROUND: On the basis of phase III CheckMate 141 results, nivolumab was approved for recurrent or metastatic head and neck cancer after undergoing platinum-containing chemotherapy in Japan. This post-marketing surveillance aimed to evaluate the safety and effectiveness of nivolumab for head and neck cancer in the real-world setting. METHODS: All patients with head and neck cancer who planned to receive nivolumab were centrally registered. This study monitored 607 patients for 6 months to assess nivolumab's safety, especially treatment-related adverse events (TRAEs) of special interest, and effectiveness. RESULTS: TRAEs occurred in 36.1% patients, with no new safety signals. The most common TRAEs with grade ≥ 3 were interstitial lung disease (1.2%), diarrhea (0.8%), and hepatic function abnormal (0.7%). Meanwhile, thyroid dysfunction (10.2%), hepatic dysfunction (5.3%), and interstitial lung disease (4.1%) were the most common TRAE categories of special interest. Although the median time to the onset of each TRAE category of special interest was mostly 1-2 months, most of them occurred throughout the observation period; nonetheless, the majority of patients recovered or remitted. The 6-month survival rate was 55.9%. CONCLUSION: Japanese patients with head and neck cancer treated with nivolumab in the real-world setting manifested no new safety signals. CLINICAL TRIAL REGISTRATION: clinicaltrials.jp: JapicCTI-184071.
    Sep. 2021, International journal of clinical oncology, 26(9) (9), 1619 - 1627, English, Domestic magazine
    Scientific journal

  • Keisuke Iritani, Daryl Anne A Del Mundo, Shinobu Iwaki, Kuriko Masuda, Maki Kanzawa, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naoki Otsuki, Ken-Ichi Nibu
    Objective: This study aimed to investigate risk factors predictive of local recurrence and/or lymph node metastasis after transoral resection of early hypopharyngeal cancer. Methods: Forty-nine consecutive patients who underwent transoral videolaryngoscopic surgery (TOVS) as an initial treatment for hypopharyngeal cancer were evaluated. On univariate and multivariate analysis, local recurrence rates were assessed respectively using log-rank test and cox regression analysis according to the following parameters: subsite, pT, mucosal margin, lymphatic invasion, vessel invasion, tumor thickness (> 4 mm vs ≤4 mm), history of esophageal cancer, and multiple Lugol-voiding lesions (LVLs) in the esophagus. Categorical variables were evaluated for their associations with lymph node metastasis using chi-squared test or Fisher's exact test. Result: The subsites of primary lesions were piriform sinus in 24 patients, posterior wall in 15 patients, and postcricoid in 10 patients. Thirty patients had esophageal cancer. Local recurrence occurred in 14 patients. Three patients had lymph node metastasis at the time of diagnosis and four patients developed lymph node metastasis after the initial treatment, resulting a total of seven patients having lymph node metastasis. While mucosal margin and LVLs showed significant associations with local recurrence on univariate analysis, only LVLs remained as a significant risk factor on multivariate analysis (P = .0395; hazard ratio = 8.897; 95% confidence interval, 1.113-71.15). Most cases of local recurrence were satisfactorily controlled by repeated TOVS. While multivariate analysis could not be performed due to the small number of the patients with lymph node metastases, venous invasion (P = .0166) and tumor thickness (P = .0092) were significantly associated with lymph node metastasis on univariate analysis. Conclusions: Local recurrence was more frequent in patients with LVLs, but most of them were salvaged by repeated TOVS. Patients with venous invasion and/or tumor thickness greater than 4 mm should be followed up with special attention to lymph node metastasis.Level of Evidence: 3.
    Aug. 2021, Laryngoscope investigative otolaryngology, 6(4) (4), 756 - 763, English, International magazine
    Scientific journal

  • Hirotaka Shinomiya, Natsumi Uehara, Takeshi Fujita, Daisuke Miyawaki, Yoshinori Imamura, Masanori Teshima, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    PURPOSE: Chemoradiotherapy with docetaxel (DOC), cisplatin (CDDP), and 5-FU (TPF-CRT) for locally advanced external auditory canal cancer (EACC) has favorable oncological and functional outcomes. To establish TPF-CRT as a standard of care for advanced EACC, we conducted this study to determine the maximum tolerated (MTD) and recommended dose (RD) of DOC in TPF-CRT for locally advanced EACC. METHODS: To determine the recommended (RD) and maximum tolerated dose (MTD) of DOC in TPF-CRT for EACC, a phase I trial was conducted using the standard "3 + 3" design for maximum dose finding. DOC was administered twice every 4 weeks, CDDP at 70 mg/m2 and 5-FU at 700 mg/m2; patients were also receiving radiotherapy (66 Gy). Eight patients with T3 or T4 EACC were prospectively enrolled. RESULTS: Two patients treated with DOC, 50 mg/m2, and one out of six patients treated with DOC, 40 mg/m2, had dose-limiting toxicities. Prolonged febrile neutropenia was observed in three patients. Grade 3 non-hematological toxicities were observed in only three patients. At study completion, six patients survived, five of whom were disease free. CONCLUSION: The RD and MTD of DOC in TPF-CRT for locally advanced EACC are 40 mg/m2 when doses of CDDP and 5-FU are 70 mg/m2 and 700 mg/m2, respectively.
    Jul. 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, English, International magazine
    Scientific journal

  • Mehmet Ozgur Avincsal, Koki Kamizaki, Naoe Jimbo, Hirotaka Shinomiya, Ken-Ichi Nibu, Michiru Nishita, Yasuhiro Minami
    Ror2 (receptor tyrosine kinase like orphan receptor 2) is highly expressed in various types of cancers; in the majority of these cancers, Ror2 expression is associated with more aggressive disease states. Recently, it has been reported that Ror2 is highly expressed in human papilloma virus (HPV)‑positive head and neck squamous cell cancer (HNSCC) cell lines, presumably indicating that Ror2 plays a critical role in HPV‑related cancers. However, the function of Ror2 in HPV‑positive HNSCC is currently unknown. Here, we first examined the expression levels of Ror2 in clinical specimens from patients with HPV‑negative and HPV‑positive oropharyngeal squamous cell cancer (OPSCC) via immunohistochemical analysis. We found that Ror2 was expressed in both HPV‑negative and HPV‑positive OPSCC tissues. We then confirmed that HPV‑positive HNSCC cell line, UPCI:SCC152 cells, express Ror2 higher than HPV‑negative cell lines as previously reported. Suppressed expression of HPV E6/7 resulted in reduced expression levels of Ror2. We also revealed that Ror2 downregulation significantly inhibited the proliferation of UPCI:SCC152 cells without inducing apoptosis. Moreover, Ror2 knockdown decelerated G1/S phase progression and abrogated invasive migration of UPCI:SCC152 cells. These results provide strong evidence that E6 and/or E7 oncoproteins regulate the progression of HPV‑positive HNSCC by upregulating Ror2 expression, suggesting that Ror2 could potentially be a novel target in HPV‑related cancers.
    Jul. 2021, Oncology reports, 46(1) (1), English, International magazine
    Scientific journal

  • 色素性乾皮症の聴力障害
    藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 163 - 163, Japanese

  • Pseudo-dominant遺伝形式を示すGJB2遺伝子変異が検出された先天性難聴児の1例
    橋本 裕依子, 上原 奈津美, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一
    日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 190 - 190, Japanese

  • 頭頸部癌のリアルワールドデータから見えてくるもの 「咽喉頭がんに対する経口的切除の有効性・安全性に関する研究」から得られたリアルワールドエビデンス
    荒木 幸仁, 吉本 世一, 冨藤 雅之, 松浦 一登, 藤原 和典, 楯谷 一郎, 梅野 博仁, 中溝 宗永, 林 隆一, 丹生 健一, 塩谷 彰浩
    (一社)日本頭頸部癌学会, May 2021, 頭頸部癌, 47(2) (2), 114 - 114, Japanese

  • 頭頸部癌のリアルワールドデータから見えてくるもの 頭頸部悪性腫瘍全国登録情報を用いた実臨床における経口的切除症例の解析
    佐野 大佑, 清水 顕, 楯谷 一郎, 藤原 和典, 岸本 曜, 丸尾 貴志, 藤本 保志, 塚原 清彰, 吉本 世一, 丹生 健一, 折舘 伸彦
    (一社)日本頭頸部癌学会, May 2021, 頭頸部癌, 47(2) (2), 113 - 113, Japanese

  • 連携、合同診療科vs専門病院、それぞれの強みと弱点 多科合同手術を施行した局所進行甲状腺癌症例の検討
    手島 直則, 寺薗 貴浩, 下田 光, 古川 竜也, 四宮 弘隆, 大月 直樹, 丹生 健一
    (一社)日本内分泌外科学会, May 2021, 日本内分泌外科学会雑誌, 38(Suppl.1) (Suppl.1), S68 - S68, Japanese

  • 藤田 岳, 横井 純, 上原 奈津美, 井之口 豪, 後藤 友佳子, 土井 勝美, 柿木 章伸, 篠原 正和, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 605 - 605, Japanese

  • 上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 639 - 639, Japanese

  • H Shinomiya, N Uehara, T Fujita, K Yoshida, Y Imamura, M Teshima, H Kimura, D Miyawaki, A Kakigi, N Kiyota, N Otsuki, R Sasaki, E Kohmura, K Nibu
    AbstractBackgroundThe prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades. MethodsNinety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T1, T2, T3 and T4 was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated. ResultsAmong patients with T4 disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T4b) was significantly lower than that of patients without these factors (T4a) (25.5 vs 65.5 per cent, p = 0.049). ConclusionIt is proposed that stage T4 be subclassified into T4a and T4b according to the prognostic factors.
    Cambridge University Press (CUP), Apr. 2021, The Journal of Laryngology & Otology, 135(4) (4), 297 - 303
    Scientific journal

  • Tatsuya Furukawa, Naoki Otsuki, Masahiro Tomotsu, Shun Tatehara, Naruhiko Morita, Yasutaka Kojima, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu
    Non-recurrent inferior laryngeal nerve (NRILN) is rare but one of the important anatomical variations in thyroid and parathyroid surgery. Almost all cases were observed on the right side with aberrant right subclavian artery and left NRILN have been reported in only five cases so far. Here, we reported a 38 year-old Japanese male with left NRILN accompanying adenomatous goiter. He was referred to our hospital for the surgical treatment of left thyroid goiter. Preoperative computed tomography revealed right-sided aortic arch and aberrant left subclavian artery with no signs of complete situs inversus viscerum, suggesting possible left NRLN. Left hemithyroidectomy was performed using nerve monitoring system. Intraoperatively, left recurrent laryngeal nerve was not identified along tracheoesophageal groove, but directly originated from vagal nerve and was running horizontally to larynx. Mobility of vocal cords were not impaired and postoperative course was uneventful. During thyroid surgery for the patients with right-sided aortic arch, meticulous care should be taken using nerve monitoring system to avoid nerve injury.
    Apr. 2021, Auris, nasus, larynx, 48(2) (2), 317 - 321, English, International magazine
    [Refereed]
    Scientific journal

  • 下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二
    日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese

  • 手島 直則, 丹生 健一
    (株)日本臨床社, Mar. 2021, 日本臨床, 79(増刊1 希少がん) (増刊1 希少がん), 258 - 260, Japanese

  • 下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二
    日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese

  • Kiyoto Shiga, Ken-Ichi Nibu, Yasushi Fujimoto, Takahiro Asakage, Akihiro Homma, Hiroki Mitani, Takenori Ogawa, Kenji Okami, Shigeyuki Murono, Shigeru Hirano, Tsutomu Ueda, Nobuhiro Hanai, Kiyoaki Tsukahara, Ichiro Ota, Seiichi Yoshimoto, Takeshi Shinozaki, Shigemichi Iwae, Katsunori Katagiri, Daisuke Saito, Naomi Kiyota, Makoto Tahara, Fumiaki Takahashi, Ryuichi Hayashi
    OBJECTIVES: This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients. METHODS: This is a multi-institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent. RESULTS: Overall 5-year survival rates of the patients who underwent CRT (n = 74) were 54.6%. Those of the patients who underwent CRT with modified TPF (docetaxel, cisplatin [CDDP], and 5-fluorouracil) regimen (n = 50) and CRT with CDDP regimens (n = 24) were 64.4% and 36.7%, respectively. Significant differences were observed between these two groups. CONCLUSION: Given the tendency that head and neck surgeons prefer CRT for advanced larger cancer of the EAC, CRT for advanced EAC cancer using the modified TPF regimen showed good clinical outcomes. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:E870-E874, 2021.
    Mar. 2021, The Laryngoscope, 131(3) (3), E870-E874, English, International magazine
    Scientific journal

  • Daisuke Sano, Akira Shimizu, Ichiro Tateya, Kazunori Fujiwara, Terushige Mori, Shunsuke Miyamoto, Daisuke Nishikawa, Tomonori Terada, Ryuji Yasumatsu, Tsutomu Ueda, Fumihiko Matsumoto, Yo Kishimoto, Takashi Maruo, Yasushi Fujimoto, Kiyoaki Tsukahara, Seiichi Yoshimoto, Ken-Ichi Nibu, Nobuhiko Oridate
    OBJECTIVES: The aim of this multicenter retrospective cohort study was to compare efficacy and subsequent postoperative treatment between transoral robotic surgery (TORS) and any non-robotic transoral surgery in Japanese patients with early oropharyngeal squamous cell carcinoma (OPSCC), hypopharyngeal SCC (HPSCC), or supraglottic SCC (SGSCC). MATERIALS AND METHODS: Clinical information and surgical outcomes were compared between patients with early-stage OPSCC, HPSCC, and SGSCC who underwent TORS (TORS cohort) and those who underwent non-robotic transoral surgery, including transoral videolaryngoscopic surgery (TOVS), endoscopic laryngopharyngeal surgery (ELPS), and transoral laser microsurgery (TLM) (non-robotic cohort). The data of the Head and Neck Cancer Registry of Japan (registry cohort) were used to validate the comparison. The main outcomes were the presence of positive margins under pathology and the requirement for postoperative therapy, including radiotherapy or chemoradiotherapy. RESULTS: Sixty-eight patients in the TORS cohort, 236 patients in the non-robotic cohort, and 1,228 patients in the registry cohort were eligible for this study. Patients in the TORS cohort were more likely to have oropharyngeal tumor disease and T2/3 disease than those in the other cohorts (P<0.001 and P=0.052, respectively). The TORS cohort had significantly fewer patients with positive surgical margins than the non-robotic cohort (P=0.018), as well as fewer patients who underwent postoperative treatment, although the difference was not significant (P=0.069). In the subgroup analysis of patients with OPSCC, a total of 57 patients in the TORS cohort, 73 in the non-robotic cohort, and 171 in the registry cohort were eligible for the present study. Patients with OPSCC who underwent TORS were more likely to have lateral wall lesions than those in the other cohorts (P=0.003). The TORS cohort also had significantly fewer patients with positive surgical margins than the non-robotic cohort (P=0.026), and no patients in the TORS cohort underwent any postoperative treatment for OPSCC, although the difference was not significant (P=0.177). CONCLUSIONS: Our results suggest that TORS leads to fewer positive surgical margins than non-robotic transoral surgeries. The clinical significance of TORS may be further validated through the results of all-case surveillance for patients who underwent TORS running in Japan in the future.
    Feb. 2021, Auris, nasus, larynx, 48(3) (3), 502 - 510, English, International magazine
    [Refereed]
    Scientific journal

  • Jun Yokoi, Shun-Gaku Yanagisawa, Akinobu Kakigi, Takeshi Fujita, Shinobu Iwaki, Yasuyuki Kajimoto, Ken-Ichi Nibu
    Japan Society for Equilibrium Research, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese
    Scientific journal

  • 横井 純, 柳沢 俊学, 柿木 章伸, 藤田 岳, 岩城 忍, 梶本 康幸, 丹生 健一
    (一社)日本めまい平衡医学会, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese

  • 三根 実穂子, 下田 光, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 手島 直則, 大月 直樹, 丹生 健一
    (NPO)日本頭頸部外科学会, Feb. 2021, 頭頸部外科, 30(3) (3), 367 - 372, Japanese

  • Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi
    BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.
    Jan. 2021, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takeshi Fujita, Akinobu Kakigi, Natsumi Uehara, Jun Yokoi, Makiko Hara, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu
    OBJECTIVE: To present our results of the external auditory canal (EAC) reconstruction procedure using rolled-up full-thickness skin graft with tympanoplasty after lateral temporal bone resection (LTBR) for early-stage EAC carcinoma. PATIENTS AND METHODS: A retrospective review of 15 patients who had undergone LTBR with reconstruction of the EAC for T1 and T2 EAC cancer between 2016 and 2020. RESULTS: Postoperative mean air-bone gap was 30.7 decibel hearing level. Although a few patients experienced chronic granulation, persistent otorrhea, and/or laterization of the tympanic membrane, most patients showed no serious complications related to the EAC reconstruction. CONCLUSION: EAC reconstruction using a full-thickness skin graft in combination with tympanoplasty is useful for minimizing the hearing loss, maintaining the cosmetic appearance, and facilitating the observation into the ear cavity.
    Jan. 2021, Auris, nasus, larynx, English, International magazine
    [Refereed]
    Scientific journal

  • Naruhiko Morita, Takayuki Murase, Kaori Ueda, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Ken-Ichi Taguchi, Hidetaka Yamamoto, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Daisuke Kawakita, Kazuo Sakurai, Toru Nagao, Nobuhiro Hanai, Ryo Kawata, Naohito Hato, Naoki Otsuki, Ken-Ichi Nibu, Hiroshi Inagaki
    Three pathological grading systems advocated by Perzin/Szanto, Spiro, and van Weert are currently used for adenoid cystic carcinoma (AdCC). In these systems, the amount or presence of the solid tumor component in AdCC specimens is an important index. However, the "solid tumor component" has not been well defined. Salivary AdCC cases (N = 195) were collected after a central pathology review. We introduced a novel criterion for solid tumor component, minAmax (minor axis maximum). The largest solid tumor nest in each AdCC case was histologically screened, the maximum oval fitting the solid nest was estimated, and the length of the minor axis of the oval (minAmax) was measured. The prognostic cutoff for the minAmax was determined using training and validation cohorts. All cases were evaluated for the four grading systems, and their prognostic impact and interobserver variability were examined. The cutoff value for the minAmax was set at 0.20 mm. Multivariate prognostic analyses showed the minAmax and van Weert systems to be independent prognostic tools for overall, disease-free, and distant metastasis-free survival while the Perzin/Szanto and Spiro systems were selected for overall survival but not for disease-free or distant metastasis-free survival. The highest hazard ratio for overall survival (11.9) was obtained with the minAmax system. The reproducibility of the minAmax system (kappa coefficient of 0.81) was scored as very good while those of the other three systems were scored as moderate. In conclusion, the minAmax is a simple, objective, and highly reproducible grading system useful for prognostic stratification for salivary AdCC.
    Jan. 2021, Cancer science, 112(3) (3), 1184 - 1195, English, International magazine
    [Refereed]
    Scientific journal

  • Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki
    BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.
    Jan. 2021, Radiation oncology (London, England), 16(1) (1), 1 - 1, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Nodular fasciitis of buccal region: A case report
    Hiroko Takeda, Shun Tatehara, Ken-Ichi Nibu
    Igaku-Shoin Ltd, 2021, Otolaryngology - Head and Neck Surgery (Japan), 93(6) (6), 447 - 450, Japanese
    Scientific journal

  • Shinobu Iwaki, Emi Wakui, Miki Takahashi, Keisuke Iritani, Hirotaka Shinomiya, Ken-Ichi Nibu
    Japan Society of Logopedics and Phoniatrics, 2021, Japan Journal of Logopedics and Phoniatrics, 62(2) (2), 116 - 122, Japanese
    Scientific journal

  • Chiaki Suzuki, Naomi Kiyota, Yoshinori Imamura, Hideaki Goto, Hirotaka Suto, Naoko Chayahara, Masanori Toyoda, Yasuhiro Ito, Akihiro Miya, Akira Miyauchi, Masanori Teshima, Naoki Otsuki, Ken-Ichi Nibu, Hironobu Minami
    Background: We previously reported that a high tumor burden is a prognostic factor based on an analysis of 26 patients with radioactive iodine-refractory differentiated thyroid cancer (RR-DTC) who were treated with lenvatinib. However, the optimal tumor burden for starting lenvatinib still remains to be defined. The aim of this retrospective study was to further explore in the same patient cohort the optimal timing for the start of lenvatinib by focusing on the pre- and post-treatment tumor burden. Methods: The 26 patients were treated with lenvatinib from 2012 to 2017. We explored the optimal timing for the start of lenvatinib by comparing the characteristics of long-term responders who were defined as patients with progression-free survival ≥ 30 months and non-long-term responders. Results: Long-term responders had a smaller post-treatment tumor burden at maximum shrinkage than non-long-term responders. Further, post-treatment tumor burden had a strong linear correlation with baseline tumor burden. We created an estimation formula for baseline tumor burden related to prognosis, using these regression lines. Patients with a sum of diameters of target lesions < 60 mm or maximum tumor diameter < 34 mm at baseline were estimated to have significantly better survival outcomes. Conclusions: We found a strong linear correlation between pre- and post-treatment tumor burden. Our results suggested a cut-off value for baseline tumor burden for long-term prognosis among patients treated with lenvatinib.
    2021, Frontiers in oncology, 11, 638123 - 638123, English, International magazine
    Scientific journal

  • Shun Tatehara, Go Inokuchi, Hiroko Takeda, Shunsuke Kuroki, Hisami Fujio, Atsushi Azumi, Ken-Ichi Nibu
    Orbital decompression (OD) for Graves' orbitopathy usually includes removal of orbital medial wall. While OD occasionally cause or worsen chronic sinusitis because of the obstructed sinus drainage by prolapsed orbital fat, to date few reports have been published on the management or prevention of sinusitis associated with OD. Here, we present two patients (three sides) with newly developed and one patient (one side) with worsening obstructive frontal sinusitis following OD. These three patients had OD including the removal of the superior attachment of uncinated process to lamina papyracea. Endoscopic modified Lothrop procedure (EMLP) was useful to relieve symptoms and keep an enough access to frontal sinuses for all cases. We also performed EMLP for another two patients (four sides) with pre-existing sinusitis before OD. Worsening of sinusitis could be avoided by EMLP before OD. EMLP was useful approach for both treatment and prevention of sinusitis related to OD. The superior attachment site of uncinated process and the pattern of frontal sinus drainage might predict the occurrence of obstructive frontal sinusitis following OD.
    Dec. 2020, Auris, nasus, larynx, 47(6) (6), 1079 - 1082, English, International magazine
    [Refereed]

  • Hidetoshi Matsuo, Mizuho Nishio, Tomonori Kanda, Yasuyuki Kojita, Atsushi K Kono, Masatoshi Hori, Masanori Teshima, Naoki Otsuki, Ken-Ichi Nibu, Takamichi Murakami
    We hypothesized that, in discrimination between benign and malignant parotid gland tumors, high diagnostic accuracy could be obtained with a small amount of imbalanced data when anomaly detection (AD) was combined with deep leaning (DL) model and the L2-constrained softmax loss. The purpose of this study was to evaluate whether the proposed method was more accurate than other commonly used DL or AD methods. Magnetic resonance (MR) images of 245 parotid tumors (22.5% malignant) were retrospectively collected. We evaluated the diagnostic accuracy of the proposed method (VGG16-based DL and AD) and that of classification models using conventional DL and AD methods. A radiologist also evaluated the MR images. ROC and precision-recall (PR) analyses were performed, and the area under the curve (AUC) was calculated. In terms of diagnostic performance, the VGG16-based model with the L2-constrained softmax loss and AD (local outlier factor) outperformed conventional DL and AD methods and a radiologist (ROC-AUC = 0.86 and PR-ROC = 0.77). The proposed method could discriminate between benign and malignant parotid tumors in MR images even when only a small amount of data with imbalanced distribution is available.
    Nov. 2020, Scientific reports, 10(1) (1), 19388 - 19388, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 難聴の遺伝学的検査から視覚症状の出現前にUsher症候群と診断した1例
    横井 純, 上原 奈津美, 藤田 学, 柿木 章伸, 丹生 健一, 西尾 信哉, 宇佐美 真一
    (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 362 - 362, Japanese

  • 当院における甲状腺癌脊椎転移に対する手術治療の検討
    下田 光, 手島 直則, 大月 直樹, 丹生 健一
    (一社)日本内分泌外科学会, Nov. 2020, 日本内分泌外科学会雑誌, 37(Suppl.2) (Suppl.2), S312 - S312, Japanese

  • 経外耳道的直達外傷による小児迷路気腫の1例
    上紺屋 達彦, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    日本小児耳鼻咽喉科学会, Nov. 2020, 小児耳鼻咽喉科, 41(2) (2), 202 - 202, Japanese

  • 外側側頭骨切除術時に皮膚管を用いた一期的外耳道・伝音再建
    藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 164 - 164, Japanese

  • 成人症例における難聴遺伝子解析の検討
    上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一, 西尾 信哉, 宇佐美 真一
    (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 277 - 277, Japanese

  • Yoshihide Okumura, Satsuki Nakano, Takayuki Murase, Kaori Ueda, Daisuke Kawakita, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Satoshi Kano, Kiyoaki Tsukahara, Kenji Okami, Toru Nagao, Nobuhiro Hanai, Hiroshi Iwai, Ryo Kawata, Yuichiro Tada, Ken-Ichi Nibu, Hiroshi Inagaki
    Mucoepidermoid carcinoma (MEC) is rare, but the most common primary malignancy of the salivary gland and not infrequent in young individuals. CRTC1/3-MAML2 fusions are frequently detected in MEC and are useful as a diagnostic biomarker. However, there has been debate as to whether the fusions have prognostic significance. In this study, we retrospectively collected 153 salivary gland MEC cases from 11 tertiary hospitals in Japan. As inclusion criteria, the MEC patients in this study had curative surgery as the initial treatment, received no preoperative treatment, and had no distant metastasis at the time of the initial surgery. The MEC diagnosis was validated by a central pathology review by five expert salivary gland pathologists. The CRTC1/3-MAML2 fusions were detected using FISH and RT-PCR. In 153 MEC cases, 90 (58.8%) were positive for CRTC1/3-MAML2 fusions. During the follow-up period, 28 (18.3%) patients showed tumor recurrence and 12 (7.8%) patients died. The presence of the fusions was associated with favorable tumor features. Of note, none of the fusion-positive patients died during the follow-up period. Statistical analysis showed that the presence of the fusions was a prognostic indicator of a better overall survival in the total and advanced-stage MEC cohorts, but not in the early-stage MEC cohort. In conclusion, CRTC1/3-MAML2 fusions are an excellent biomarker for favorable overall survival of patients with salivary gland MEC.
    Nov. 2020, Cancer science, 111(11) (11), 4195 - 4204, English, International magazine
    [Refereed]
    Scientific journal

  • 頭頸部癌に対する機能温存治療の現状と将来展望 HPV関連中咽頭癌治療の現状と将来展望
    齊藤 祐毅, 家根 旦有, 丹生 健一
    (一社)日本癌治療学会, Oct. 2020, 日本癌治療学会学術集会抄録集, 58回, SY7 - 2, English

  • 横井 純, 柳沢 俊学, 柿木 章伸, 岩城 忍, 藤田 岳, 丹生 健一
    (一社)日本めまい平衡医学会, Oct. 2020, Equilibrium Research, 79(5) (5), 456 - 456, Japanese

  • Daisuke Kawakita, Takayuki Murase, Kaori Ueda, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Takuma Matoba, Kazuo Sakurai, Toru Nagao, Nobuhiro Hanai, Ryo Kawata, Naohito Hato, Ken-Ichi Nibu, Makoto Urano, Ken-Ichi Taguchi, Masato Nakaguro, Kimihide Kusafuka, Hidetaka Yamamoto, Toshitaka Nagao, Hiroshi Inagaki
    BACKGROUND: Owing to the low incidence of adenoid cystic carcinoma (AdCC), reliable survival estimates and prognostic factors remained unclarified. METHODS: In this multi-institutional retrospective analysis, we collected 192 AdCC cases, and investigated the impact of clinicopathological factors on clinical outcomes of the patients. All AdCC cases were of salivary gland origin and were surgically treated with curative intent. Diagnoses of AdCC were validated by a central pathology review by expert pathologists. RESULTS: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 92.5 and 50.0%, respectively. Treatment failure occurred in 89 patients (46%) with the distant failures in 65 (34%). Multivariate analysis indicated that pN2 and a pathologically positive surgical margin were independent prognostic factors for both OS and DFS. Histological grade III was an independent prognostic factor for OS. A primary site in the submandibular gland, pT3/4, pN1, and histological grade II were independent prognostic factors for DFS. Postoperative radiation therapy (PORT) improved the locoregional control (LRC) rate. Prophylactic neck dissection was not associated with a better OS or better LRC among patients with cN0. Facial nerve dissection did not improve clinical outcomes in parotid AdCC cases without facial nerve palsy. CONCLUSIONS: A higher TN classification, a pathologically positive surgical margin, and a higher histological grade were associated with a lower OS. PORT improved LRC rates but neck dissection failed to improve clinical outcomes in patients with cN0. As the distant metastasis was frequent, effective systemic therapy is imperative to improve the survival of AdCC patients.
    Oct. 2020, International journal of clinical oncology, 25(10) (10), 1774 - 1785, English, Domestic magazine
    Scientific journal

  • Hisami Fujio, Go Inokuchi, Shunsuke Kuroki, Shun Tatehara, Sayaka Katsunuma, Hisamoto Kowa, Ken-Ichi Nibu
    OBJECTIVE: We conducted a 3-year prospective study on olfaction of patients with Parkinson's disease (PD) in order to examine the severity and frequency of smell disorder in PD using odor identification test, Open Essence (OE) and to verify the validity of olfactory tests as a predictor of cognitive symptom onset of PD. PATIENTS AND METHODS: We conducted a prospective study by performing an annual examination over a 3-year period. For 56 cases diagnosed with PD by the Department of Neurology at our hospital, OE and Jet Stream Olfactometry (JSO) were performed to assess the olfactory function, and Mini-Mental-State Examination (MMSE) was conducted to measure cognitive impairment. RESULTS: At the beginning, 56 cases were examined, of which 42 remained to be followed up for 3 years. Based on the results of baseline, we found a correlation between OE and the average cognitive thresholds of JSO, but did not find any correlation between OE and MMSE. OE (median 4.0→4.0) and the average cognitive thresholds of JSO (median 2.2→1.6) decreased after 3 years, and MMSE (median 29→29) also declined, but not significantly. At the 3rd year, 6 cases with MMSE score of 23 or less were identified as suspected dementia and 36 cases with more than 24 points were defined as an invariant group. In order to distinguish these two groups, OE scores of baselines were evaluated with a combination of 12 odors. Sensitivity 1.0 and specificity 0.722 were obtained and the sensitivity+specificity value (1.722) was the highest when the number of correct answers was 4 or less using an odor combination of lumber, menthol, Japanese orange, gas for household use, Hinoki cypress and condensed milk. CONCLUSION: When the number of correct answers of 6 odors (lumber, menthol, Japanese orange, gas for household use, Hinoki cypress and condensed milk) is 4 or less in patients with PD, there is a possibility that MMSE declines in 3 years.
    Oct. 2020, Auris, nasus, larynx, 47(5) (5), 899 - 904, English, International magazine
    [Refereed]
    Scientific journal

  • Naoki Otsuki, Hikari Shimoda, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu
    To clarify the patterns of the recurrence and to assess the oncological and functional outcomes after salvage surgery for the patients with structural local recurrence of papillary thyroid cancer (PTC), twenty-five patients who underwent salvage surgery for structural local recurrence of PTC were retrospectively reviewed. Structural recurrences were observed in the tracheal lumen in 5 patients, intraluminal or intramuscular esophagus in 5 patients, trachea, and cricoid cartilage in 9 patients, cricoid and thyroid cartilage in 2 patients, intra-lumen of the larynx in 1 patient and soft tissue around thyroid in 3 patients, respectively. Although all local disease was resected with macroscopically negative margin, 10 patients diagnosed as microscopically positive margin. Major surgical complications occurred in 6 patients, including common carotid artery injury (n = 1), unintentional pharyngeal or esophageal injury (n = 2), recurrent laryngeal nerve paralysis (n = 2), and pharyngeal fistula resulting in common carotid artery rupture (n = 1), and were successfully managed. During the follow-up periods, 6 patients were alive without disease, 15 patients survived with distant metastases and/or locoregional recurrence, and 4 patients died of the disease. While tracheocutaneous fistula remained in 7 patients, the vocal function was preserved in all patients but one who underwent total laryngectomy. Normal oral intake was retained in all patients. In conclusion, although salvage surgery for structural recurrence of PTC has a high risk of complications, it may be worthwhile when macroscopic curative resection is available. The decision should be made considering various factors including curability, risk of surgical procedure, functional outcome, and life expectancy.
    Sep. 2020, Endocrine journal, 67(9) (9), 949 - 956, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yuki Saito, Ryuichi Hayashi, Yoshiyuki Iida, Takatsugu Mizumachi, Takashi Fujii, Fumihiko Matsumoto, Takeshi Beppu, Masafumi Yoshida, Hirotaka Shinomiya, Ryosuke Kamiyama, Mutsukazu Kitano, Kazuhiko Yokoshima, Yasushi Fujimoto, Takanori Hama, Taku Yamashita, Kenji Okami, Kouki Miura, Takuo Fujisawa, Daisuke Sano, Hisayuki Kato, Shujiro Minami, Masashi Sugasawa, Muneyuki Masuda, Ichiro Ota, Shigemichi Iwae, Ryo Kawata, Nobuya Monden, Takayuki Imai, Takahiro Asakage, Masafumi Okada, Takanori Yoshikawa, Kensuke Tanioka, Megumi Kitayama, Mariko Doi, Satoshi Fujii, Masato Fujii, Nobuhiko Oridate, Munenaga Nakamizo, Seiichi Yoshimoto, Akihiro Homma, Ken-Ichi Nibu, Katsunari Yane
    BACKGROUND: Although the American Joint Committee on Cancer TNM classification has been amended to include human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) as an independent entity, to the authors' knowledge the optimized de-escalating treatment modality has not been established to date. METHODS: The authors conducted a retrospective, nationwide, observational study in patients with HPV-related OPSCC who were treated from 2011 to 2014 in Japan to determine the best treatment modality. RESULTS: A total of 688 patients who were newly diagnosed with HPV-related OPSCC who were treated with curative intent at 35 institutions and had coherent clinical information and follow-up data available were included in the current study. In patients with T1-T2N0 disease (79 patients), both the 3-year recurrence-free survival and overall survival (OS) rates were 100% in the group treated with radiotherapy (RT) as well as the group receiving concurrent chemoradiotherapy (CCRT). The 3-year OS rates were 94.4% (for patients with T1N0 disease) and 92.9% (for patients with T2N0 disease) among the patients treated with upfront surgery. In patients with stage I to stage II HPV-related OPSCC, the 5-year recurrence-free survival and OS rates were 91.4% and 92%, respectively, in the patients treated with CCRT with relatively high-dose cisplatin (≥160 mg/m2 ; 114 patients) and 74.3% and 69.5%, respectively, in the patients treated with low-dose cisplatin (<160 mg/m2 ; 17 patients). CONCLUSIONS: Despite it being a retrospective observational trial with a lack of information regarding toxicity and morbidity, the results of the current study demonstrated that patients with T1-T2N0 HPV-related OPSCC could be treated with RT alone because of the equivalent outcomes of RT and CCRT, and patients with stage I to stage II HPV-related OPSCC other than those with T1-T2N0 disease could be treated with CCRT with cisplatin at a dose of ≥160 mg/m2 .
    Sep. 2020, Cancer, 126(18) (18), 4177 - 4187, English, International magazine
    Scientific journal

  • Hidehito Kimura, Masaaki Taniguchi, Hirotaka Shinomiya, Masanori Teshima, Yuichi Fujita, Kazunobu Hashikawa, Ken-Ichi Nibu, Eiji Kohmura
    Temporal bone cancer is extremely rare; thus, the optimal surgical strategy for advanced tumors, en bloc vs piecemeal resection, remain controversial. Some authors have favored piecemeal resection and reported comparable outcomes.1 Other authors recommend the use of en bloc subtotal temporal bone resection (STBR) for advanced tumors and reported better outcomes, although long-term cancer control remains uncertain.2 Because of the technical difficulty and the lack of demonstrative surgical videos, STBR has not been sufficiently distributed. This video demonstrates en bloc STBR in a stepwise manner with particular focus on the neurosurgeon's role and aims to improve its safety, feasibility, and distribution. This video conforms to the description of Osawa et al3 in the designations for each segment of the petrous ICA. A 67-yr-old man suffered from consistent otorrhea and underwent tympanoplasty at an outside hospital 1 yr earlier. Following a histopathological diagnosis of squamous cell carcinoma in the specimen, he underwent chemoradiotherapy (cisplatin + 70 Gy). However, a current imaging revealed a recurrent tumor and he was admitted to our hospital for radical resection. Computed tomography revealed a disrupted external auditory canal and magnetic resonance imaging indicated a carcinoma equivalent to Pittsburg stage T3. The patient underwent radical STBR without complications. His postoperative course was uneventful. At 2 yr postoperative, his modified Rankin scale score was 1, no recurrence was noted, and his facial nerve function was restored to House-Brackmann Grade IV. This video was reproduced with informed consent from the patient.
    Sep. 2020, Operative neurosurgery (Hagerstown, Md.), 19(4) (4), E402-E403, English, International magazine
    [Refereed]
    Scientific journal

  • 岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Sep. 2020, Audiology Japan, 63(5) (5), 333 - 333, Japanese

  • 端山 昌樹, 識名 崇, 井之口 豪, 蓼原 瞬, 前田 陽平, 丹生 健一, 猪原 秀典
    (一社)日本耳鼻咽喉科頭頸部外科学会, Sep. 2020, 日本耳鼻咽喉科学会会報, 123(4) (4), 1147 - 1147, Japanese

  • 高橋 美貴, 古川 竜也, 涌井 絵美, 岩城 忍, 入谷 啓介, 四宮 弘隆, 丹生 健一
    日本嚥下医学会, Sep. 2020, 嚥下医学, 9(2) (2), 221 - 227, Japanese

  • Tatsuya Furukawa, Kotaro Tamagawa, Kenta Fukui, Shinobu Iwaki, Miki Takahashi, Keisuke Iritani, Hirotaka Shinomiya, Masanori Teshima, Naoki Otsuki, Makoto Kano, Ken-Ichi Nibu
    Vertical partial laryngectomy is a well-established surgical procedure for early glottic cancers with acceptable functional and oncological outcomes. However, on a long-term basis, aspiration might be a serious problem with aging. Here we presented two cases of refractory aspiration pneumonia after vertical laryngectomy. Case 1: A 76-year old gentleman with a past history of malignant lymphoma treated by chemotherapy and radiotherapy had glottic cancer, which was treated by repeated vertical partial laryngectomies. Although glottic caner had been well controlled, he started to suffer from refractory aspiration pneumonia. Since his cervical skin was very thin and hard and his general condition was poor, we employed modified Kano's method for glottic closure. Case 2: A 87-year old Japanese male had a past history of glottic cancer treated by radiotherapy and vertical partial laryngectomy. He was repeatedly hospitalized for severe aspiration pneumonia. At the age of 87, he had second primary oropharyngeal cancer. Kano's method was simultaneously performed at the time of resection of oropharyngeal cancer. Postoperative courses were uneventful without sign of leakage in both cases. The patients started oral intake 2 weeks after the surgery. They have been alive without aspiration pneumonia and takes normal diet.
    Aug. 2020, Auris, nasus, larynx, 48(6) (6), 1221 - 1225, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 四宮 弘隆, 川口 了子, 手島 正則, 蓼原 瞬, 入谷 啓介, 古川 達也, 大月 直樹, 丹生 健一
    (NPO)日本気管食道科学会, Aug. 2020, 日本気管食道科学会会報, 71(4) (4), 291 - 296, Japanese

  • Kaori Ueda, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Masato Nakaguro, Ken-Ichi Taguchi, Ayako Masaki, Hideaki Hirai, Daisuke Kawakita, Kiyoaki Tsukahara, Naohito Hato, Toru Nagao, Yasushi Fujimoto, Kazuo Sakurai, Nobuhiro Hanai, Satoshi Kano, Tetsuro Onitsuka, Kenji Okami, Ken-Ichi Nibu, Yuichiro Tada, Ryo Kawata, Hiroshi Inagaki
    BACKGROUND: To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC). METHODS: Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re-evaluation. RESULTS: After the review, the AdCC diagnosis was revised in 21/219 cases (9.6%). The six benign tumors (2.7%) comprised five basal cell adenomas and one pleomorphic adenoma, and among these six patients, three received postoperative radiotherapy. The remaining 15 malignant tumors (6.8%) comprised nine basal cell adenocarcinomas and six other carcinomas. All revised basal cell adenoma/adenocarcinoma cases were of rare cribriform variants. CONCLUSIONS: A significant proportion of AdCC pathology reports were revised after the central pathology review. It should be emphasized that the greatest attention should be paid in differentiating AdCC from cribriform variant basal cell adenoma/adenocarcinoma, which is very rare in salivary gland tumors.
    Aug. 2020, Head & neck, 42(8) (8), 1721 - 1727, English, International magazine
    [Refereed]
    Scientific journal

  • Akinobu Kakigi, Naoya Egami, Natsumi Uehara, Takeshi Fujita, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba
    The symptoms of Meniere's disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere's disease. Based on this, we developed a clinically relevant animal model of Meniere's disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner's membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist.
    Jul. 2020, Scientific reports, 10(1) (1), 12271 - 12271, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • C. Suzuki, N. Kiyota, Y. Imamura, J. Rikitake, S. Sai, T. Koyama, Y. Hyogo, Y. Nagatani, Y. Funakoshi, M. Toyoda, N. Otsuki, KI. Nibu, H. Minami
    Springer Science and Business Media LLC, Jul. 2020, International Journal of Clinical Oncology, 25(7) (7), 1270 - 1277
    Scientific journal

  • 頭頸部癌治療後の鼻咽腔閉鎖機能評価法としてのBlowing Time RatioとHigh-resolution Manometryの相関
    古川 竜也, 小松 弘和, 高橋 美貴, 上岡 美和, 入谷 啓介, 四宮 弘隆, 蓼原 瞬, 手島 直則, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 203 - 203, Japanese

  • 当科における唾液腺腺房細胞癌14例の検討
    下田 光, 大月 直樹, 窪田 雄一, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 214 - 214, Japanese

  • 小児・若年の上咽頭癌3例の治療経験
    宮脇 大輔, 妹尾 悟史, 窪田 光, 川口 弘毅, 石原 武明, 植村 優, 山本 暢之, 今村 善宣, 清田 尚臣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 168 - 168, Japanese

  • 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討
    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 174 - 174, Japanese

  • 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討
    高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣
    (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 185 - 185, Japanese

  • Natsumi Uehara, Naoki Otsuki, Mie Kubo, Junko Kitamoto, Yasutaka Kojima, Masanori Teshima, Hirotaka Shinomiya, Toshiro Shirakawa, Ken‐ichi Nibu
    Jun. 2020, Cancer Reports
    Scientific journal

  • 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 大月 直樹, 丹生 健一
    (NPO)日本頭頸部外科学会, Jun. 2020, 頭頸部外科, 30(1) (1), 105 - 112, Japanese

  • 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 大月 直樹, 丹生 健一
    (NPO)日本頭頸部外科学会, Jun. 2020, 頭頸部外科, 30(1) (1), 105 - 112, Japanese

  • Natsumi Uehara, Naoki Otsuki, Mie Kubo, Junko Kitamoto, Yasutaka Kojima, Masanori Teshima, Hirotaka Shinomiya, Toshiro Shirakawa, Ken-Ichi Nibu
    BACKGROUND: Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous cell carcinomas (HNSCCs). Midkine expression is restricted in adult tissues but is increased in several malignant tumors, including HNSCCs. AIM: Here, we evaluated the antitumor effect of Midkine promoter-based conditionally replicative adenovirus expressing siRNA against EGFR for targeting HNSCCs expressing Midkine. METHODS AND RESULTS: A conditionally replicative adenovirus vector controlled by the Midkine promoter, Ad-MK-siEGFR, was generated by integrating gene-expressing siRNA against EGFR. Antitumor effect of Ad-MK-siEGFR was tested in vitro using established HNSCC cell line, T891 with strong Midkine expression. Expression of EGFR in T891 infected with Ad-MK-siEGFR was significantly lower than that of T891 infected with control. Cytotoxicity assays showed significant growth suppression of Ad-MK-siEGFR in T891 cells. CONCLUSIONS: This study demonstrated the possibility of oncolytic therapy using the Midkine promoter-based conditional replication-selective adenovirus containing siRNA against EGFR in HNSCC cell line T891. Further validation of the findings in more cell lines and in vivo should be performed to clarify the potential clinical application.
    Jun. 2020, Cancer reports (Hoboken, N.J.), 3(3) (3), e1231, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hirokazu Komatsu, Kazuo Kumoi, Go Inokuchi, Kimio Hashimoto, Toshitaka Nagao, Naoki Otsuki, Ken-Ichi Nibu
    An 18-year-old man had a painless, elastic, firm mass in his left parotid area that gradually increased in size over a period of 6 months. At the time of examination, the parotid mass was poorly mobile and 46 mm in size. Although fine needle aspiration cytology revealed no malignant findings, we suspected a malignancy because the movement of his left mouth angle was slightly impaired; facial nerve paralysis as a result of tumor invasion was suspected. A superficial parotidectomy was performed. The tumor had a strong adhesion to the subcutaneous tissue and facial nerve. Histologically, multiple, randomly distributed cystic structures containing keratinized lamellae were present. The cystic spaces were lined with stratified squamous epithelium lacking a granular layer, and no skin appendage was observed. We diagnosed this case as a keratocystoma. Keratocystoma of the parotid gland is a rare benign tumor with only 6 cases reported worldwide. This case is the first to describe facial nerve palsy in association with a keratocystoma.
    Jun. 2020, Auris, nasus, larynx, 47(3) (3), 481 - 484, English, International magazine
    [Refereed]
    Scientific journal

  • Maki Morita, Takayuki Murase, Yoshihide Okumura, Kaori Ueda, Yuma Sakamoto, Ayako Masaki, Daisuke Kawakita, Yuichiro Tada, Ken-Ichi Nibu, Yasuyuki Shibuya, Hiroshi Inagaki
    AIMS: Mucoepidermoid carcinoma (MEC) is one of the most common salivary gland carcinomas. Epidermal growth factor receptor (EGFR) signalling pathway gene mutations are important in predicting a patient's prognosis, selecting molecularly targeted drugs and estimating the efficacy of a molecular therapy. However, their significance in MEC have been poorly clarified. CRTC1/3-MAML2 fusions are specific to MEC and may be associated with favourable characteristics in these patients. METHODS AND RESULTS: We looked for CRTC1/3-MAML2 fusions and gene alterations in the EGFR, RAS family (KRAS, HRAS and NRAS), PIK3CA, BRAF and AKT1 in 101 MEC cases. We also examined mutations in TP53. CRTC1/3-MAML2 fusions were found in 62.4% of the cases. KRAS, HRAS and PIK3CA mutations were detected in 6.9%, 2.0% and 6.9%, respectively, but other EGFR pathway genes were not mutated. In total, gene mutations (RAS/PIK3CA) in the EGFR pathway were detected in 14.9% of the cases. TP53 mutations were found in 20.8%. CRTC1/3-MAML2 fusions were associated with a better prognosis and RAS/PIK3CA mutations a worse prognosis of the patients, respectively, and both were selected as independent prognostic factors for the overall survival of the patients. TP53 mutations had no prognostic impact. CRTC1/3-MAML2 fusion-positive rates were inversely associated with the patients' age and the fusions were found in 82% of patients aged < 30 years. CONCLUSIONS: RAS/PIK3CA mutations were frequently detected, and may be a biomarker for a poorer prognosis in MEC patients. CTRC1/3-MAML2 fusions were positive in most of the young MEC patients.
    Jun. 2020, Histopathology, 76(7) (7), 1013 - 1022, English, International magazine
    [Refereed]
    Scientific journal

  • Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi
    BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.
    Corresponding, Jun. 2020, International journal of clinical oncology, 25(6) (6), 1067 - 1071, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 山下 俊彦, 梶本 康幸, 四宮 瞳, 大月 直樹, 丹生 健一
    (株)医学書院, May 2020, 耳鼻咽喉科・頭頸部外科, 92(6) (6), 469 - 473, Japanese

  • Daryl Anne A Del Mundo, Koichi Morimoto, Kuriko Masuda, Shinobu Iwaki, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Daisuke Miyawaki, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu
    OBJECTIVE: To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer. PATIENTS AND METHODS: Fifty-five consecutive patients who underwent CO2 laser cordectomy for early glottic cancer were retrospectively reviewed. RESULTS: Overall survival, larynx preservation, and relapse free local control rates were 96%, 100%, and 91%, respectively. Five patients with local recurrences were salvaged with re-cordectomy and/or radiotherapy. In type I cordectomy, VHI-10 consistently improved during postoperative course and VHI-10 at postoperative 12months was significantly better than preoperative value (2.3 vs. 9.4, p=0.02). Perceptual grading, MPT, MFR and AC/DC also improved and were better than preoperative values. In type III cordectomy, shimmer at 12months after cordectomy was significantly better than preoperative value (14.7 vs. 9.3, p=0.007). CONCLUSIONS: These results further support the rationale of CO2 cordectomy as initial and salvage surgery for early glottic cancer.
    Apr. 2020, Auris, nasus, larynx, 47(2) (2), 276 - 281, English, International magazine, Co-authored internationally
    [Refereed]
    Scientific journal

  • 大月 直樹, 下田 光, 古川 竜也, 四宮 弘隆, 手島 直則, 丹生 健一
    (NPO)日本頭頸部外科学会, Feb. 2020, 頭頸部外科, 29(3) (3), 259 - 265, Japanese

  • Naoki Otsuki, Tatsuya Furukawa, Mehmet Ozgur Avinçsal, Masanori Teshima, Hirotaka Shinomiya, Taro Oshikiri, Tetsu Nakamura, Tadashi Nomura, Kazunobu Hashikawa, Ken-Ichi Nibu
    OBJECTIVE: Free flap reconstruction in elderly patients is one of the most challenging surgeries in the treatment of head and neck cancers. The aim of this study was to examine the oncological and functional outcomes of free flap reconstruction for elderly patients with head and neck cancer. METHODS: We retrospectively reviewed elderly patients who underwent free flap reconstruction for the treatment of head and neck cancers. All patients were 80 years or older. Clinicopathologic features, surgical procedures, oncological and functional outcomes were obtained from medical records. RESULTS: Free flap reconstructions were performed in 13 patients (3 female, 10 male). The mean age was 82.6 ± 3.4 years (range: 80-91). The mean follow-up period was 23.3 months (range 4-41 months). The mean disease-free survival was 49 ± 6 months (range 4-60 months). All patients had been alive more than one year after surgery. Reconstruction was performed using free jejunum in 10 patients and radial forearm flap in 3 patients. Graft necrosis occurred in 2 patients. Other two patients experienced major postoperative medical complications. CONCLUSION: Free flap reconstruction in well-selected older adults is safe and effective. Advanced age should not preclude consideration of free flap reconstruction in those patients.
    Feb. 2020, Auris, nasus, larynx, 47(1) (1), 123 - 127, English, International magazine, Co-authored internationally
    [Refereed]
    Scientific journal

  • A case of actinomycosis masquerading as a parotid malignant tumor
    Toshihiko Yamashita, Yasuyuki Kajimoto, Hitomi Shinomiya, Naoki Otsuki, Ken-Ichi Nibu
    Igaku-Shoin Ltd, 2020, Otolaryngology - Head and Neck Surgery (Japan), 92(6) (6), 469 - 473, Japanese
    Scientific journal

  • Natsumi Uehara, Takeshi Fujita, Ken-ichi Nibu, Akinobu Kakigi
    2020, ACTA OTO-LARYNGOLOGICA CASE REPORTS, 5(1) (1), 101 - 105, English
    Scientific journal

  • Takeshi Ioroi, Naomi Kiyota, Yoshinori Imamura, Masaaki Tanda, Shiori Aoki, Mamoru Okuno, Kazuhiro Yamamoto, Ryohei Sasaki, Ken-Ichi Nibu, Hironobu Minami, Midori Hirai, Ikuko Yano
    Background: Oral mucositis frequently occurs in cancer patients treated with chemotherapy and chemoradiotherapy (CRT). This study examined the safety and efficacy of ibuprofen gargle in healthy volunteers and patients with chemotherapy- and concomitant CRT-induced oral mucositis. Methods: We enrolled healthy volunteers and patients with chemotherapy- and CRT-induced oral mucositis. In cohort I, single and multiple doses of ibuprofen gargle (0.6% or 1.0%) were administered to healthy volunteers on day 1 and days 4-10. In cohort II, multiple doses of ibuprofen gargle (0.6%) were administered to patients with complicated grade 2-3 oral mucositis based on the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. The primary endpoint of cohort I was the treatment-related adverse events (TRAEs) as defined by CTCAE version 4.0. The primary endpoint of cohort II was the change in the visual analogue scale (VAS) pain score from before to 15 min after gargle use on day 3. The incidence and severity of TRAEs were assessed based on the CTCAE version 4.0 and a subjective rating scale completed by healthy volunteers and patients. Results: In cohort I, 9 of 10 healthy volunteers were evaluable for safety. All 9 healthy volunteers reported the TRAE of oral irritation with single or multiple use of the gargle. In cohort II, 10 patients were enrolled and evaluable for safety and 7 of 10 patients were evaluable for efficacy. The mean change in the VAS pain score from before to 15 min after using the gargle on day 3 was - 1.28 (95% confidence interval: - 2.06, - 0.51), and all patients experienced some degree of pain relief (range: - 0.2 to - 2.5). All 10 patients reported the TRAE of oral irritation. No other TRAEs of ibuprofen gargle were observed in the healthy volunteers and patients. Conclusion: Despite oral irritation, the ibuprofen gargle appeared to be safe and effective for the pain related to chemo- or CRT-induced oral mucositis. However, ibuprofen-related oral irritation warrants further formulation improvement. Trial registration: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000014433).
    2020, Journal of pharmaceutical health care and sciences, 6, 12 - 12, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 手島 直則, 大月 直樹, 下田 光, 森田 成彦, 古川 竜也, 四宮 瞳, 四宮 弘隆, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Dec. 2019, 日本耳鼻咽喉科学会会報, 122(12) (12), 1561 - 1562, Japanese

  • 【舌がん・口腔がん治療の最前線】診断 診断の進め方 新しいTNM分類では,何をどのように明らかにする必要があるのか
    四宮 弘隆, 丹生 健一
    Last, (株)医学書院, Dec. 2019, 耳鼻咽喉科・頭頸部外科, 91(13) (13), 1094 - 1097, Japanese
    [Invited]
    Scientific journal

  • 【舌がん・口腔がん治療の最前線】支持療法 嚥下障害への対応戦略 術前評価から誤嚥防止手術まで
    古川 竜也, 丹生 健一
    (株)医学書院, Dec. 2019, 耳鼻咽喉科・頭頸部外科, 91(13) (13), 1155 - 1163, Japanese
    [Invited]

  • ANL Secondary Publication 甲状腺癌に対する甲状腺全摘後の術後副甲状腺機能低下症について
    手島 直則, 大月 直樹, 下田 光, 森田 成彦, 古川 竜也, 四宮 瞳, 四宮 弘隆, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Dec. 2019, 日本耳鼻咽喉科学会会報, 122(12) (12), 1561 - 1562, Japanese
    [Refereed][Invited]
    Scientific journal

  • Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hirotaka Shinomiya, Masanori Teshima, Yasutaka Kojima, Ken-Ichi Nibu
    Papillary thyroid carcinoma (PTC) occasionally invades tracheal cartilages. We adapted a reconstructive procedure "modified spiral tracheoplasty" to extensive tracheal defect after resection of locally advanced thyroid cancer. Extensive window resection of tracheal wall was performed in a 72-year-old woman and a 48-year-old man with PTC invading intraluminal trachea. Remaining stumps of trachea were separated from the esophageal wall and were rotated by 90 degrees in opposite directions. Posterior and lateral walls were anastomosed and tracheocutaneous fistula was created to prevent postoperative airway obstruction. Postoperative course was uneventful in both cases. Tracheocutaneous fistula was successfully closed 3 to 4 months after the initial surgery. Modified spiral tracheoplasty is a safe and useful method to recreate a framework of trachea after extensive window resection for advanced thyroid cancer.
    Dec. 2019, Auris, nasus, larynx, 46(6) (6), 946 - 951, English, International magazine
    [Refereed]
    Scientific journal

  • Hisami Fujio, Naoki Otsuki, Yuto Horichi, Shungaku Yanagisawa, Mari Nishio, Masanori Teshima, Hirotaka Shinomiya, Kazunobu Hashikawa, Ken-Ichi Nibu
    Cardiac metastasis from head and neck cancers are very rare. Metastases to heart are mostly diagnosed at autopsy, and seldom found while patients are alive. Patients with cardiac metastasis do not present with specific symptoms in the early stages, and diagnosis is often delayed until the disease has advanced significantly. Here, we report a 66-year-old lady who was diagnosed with cardiac metastasis 10 months after surgical resection of oral cancer. She died one month following the discovery of cardiac metastasis. Cardiac metastasis should be considered when unexplained and progressive decline of general health is observed, even in the absence of abnormalities on the electrocardiogram. Early diagnosis may be made by analyzing the chronological changes in the cardiac accumulation of fluorodeoxyglucose during positron emission tomography-computed tomography scan.
    Corresponding, Dec. 2019, Auris, nasus, larynx, 46(6) (6), 902 - 906, English, International magazine
    [Refereed]
    Scientific journal

  • 【がん研究10か年戦略の成果と課題-基礎から実用化までをつなぐ研究開発】臨床研究 医療技術の開発 頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    丹生 健一, 中溝 宗永, 家根 旦有
    医歯薬出版(株), Nov. 2019, 医学のあゆみ, 271(9) (9), 1002 - 1005, Japanese
    [Refereed]

  • Tomomi Yoneda, Naoto Kunimura, Koichi Kitagawa, Yuka Fukui, Hiroki Saito, Keita Narikiyo, Motoki Ishiko, Naoki Otsuki, Ken-Ichi Nibu, Masato Fujisawa, Satoshi Serada, Tetsuji Naka, Toshiro Shirakawa
    Prostate cancer is one of the most common cancers in men. The overactivation of IL-6/JAK/STAT3 signaling and silencing of SOCS3 are frequently observed in prostate cancer. In the present study we undertook to develop Ad-SOCS3 gene therapy for the treatment of prostate cancer and also investigated whether Ad-SOCS3 increased sensitivity to NK cells. We demonstrated that Ad-SOCS3 could significantly inhibit growth of castration-resistant prostate cancer (CRPC) cell lines expressing pSTAT3, DU-145 (at 10, 20, and 40 MOI), and TRAMP-C2 (at 40 MOI), but not the PC-3 CRPC cell line with the STAT3 gene deleted. Ad-SOCS3 (40 MOI) could suppress IL-6 production in DU-145 cells and PD-L1 expression induced by IFN-γ in TRAMP-C2 cells, and increased the NK cell sensitivity of both TRAMP-C2 and DU-145 cells. In the DU-145 mouse xenograft tumor model, intratumoral injections (twice/week for 3 weeks) of 1 × 108 pfu of Ad-SOCS3 significantly inhibited tumor growth and combining the Ad-SOCS3 treatment with intratumoral injections (once/week for 2 weeks) of 1 × 107 human NK cells showed the highest tumor growth inhibitory effect. These results suggested that a combination of Ad-SOCS3 gene therapy and NK cell immunotherapy could be a powerful treatment option for advanced CRPC overexpressing pSTAT3.
    Nov. 2019, Cancer gene therapy, 26(11-12) (11-12), 388 - 399, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 色素性乾皮症の聴力障害とモデルマウスの聴覚解析
    藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese

  • 藤田 岳, 柿木 章伸, 丹生 健一
    (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 441 - 441, Japanese

  • TEESが有用であった両側先天性真珠腫に対する同時手術の2例
    上田 隆, 由井 光子, 赤澤 亜由, 上原 奈津美, 藤田 岳, 後藤 友佳子, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 207 - 207, Japanese

  • 色素性乾皮症の聴力障害とモデルマウスの聴覚解析
    藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese

  • 【医療情報をどう活用するか】遺伝情報をどう管理し、活用するか 頭頸部腫瘍領域
    森田 成彦, 丹生 健一
    (株)東京医学社, Oct. 2019, JOHNS, 35(10) (10), 1455 - 1458, Japanese
    [Refereed]

  • Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Akinori Kakigi, Naoki Otsuki, Ken-Ichi Nibu
    OBJECTIVE: The purpose of this study was to clarify the impact of superficial parotidectomy and postoperative radiotherapy (PORT) for the surgical treatment of early stage squamous cell carcinoma (SCC) in external auditory canal (EAC). MATERIALS AND METHODS: Thirty-seven patients with T1 (n = 14) or T2 (n = 19) SCC in EAC treated between 2000 and 2016 at Kobe University Hospital were enrolled in this study. Thirty-three patients were operated with sleeve resection or lateral temporal bone resection. RESULTS: The 5-year overall survival and disease-specific survival rates were 95% and 100%, respectively. Surgical margin was positive in 4 patients, who were treated by PORT and have been alive without disease. Prophylactic superficial parotidectomy was simultaneously performed at the time of initial surgery in 15 patients, in whom no lymph node (LN) metastasis was observed. Among the other 22 patients, regional recurrence in parotid LN was observed in one patient, who was successfully salvaged by total parotidectomy. Potential parotid lymph node metastasis rates of T1 and T2 SCC in EAC was 0% (0/14) and 5% (1/19) respectively. CONCLUSIONS: Complete resection without positive surgical margins is essential for the treatment of the patients with T1 and T2 ear cancers. Prophylactic superficial parotidectomy or neck dissection is not mandatory for T1 and T2 diseases, as long as precisely extent of disease is assessed preoperatively. PORT should be performed for the patients with positive surgical margins. LEVELS OF EVIDENCE: 4.
    Oct. 2019, Auris, nasus, larynx, 46(5) (5), 785 - 789, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akinobu Kakigi, Teruhiko Okada, Taizo Takeda, Natsumi Uehara, Ken-Ichi Nibu
    Objective The endocytosis of cationized feritin (CF) via a clathrin-mediated pathway is regulated by a signaling network. Marginal cells showed the active endocytosis of CF via a clathrin-mediated pathway. The internalization of receptors through this clathrin-mediated pathway is an important regulatory event in signal transduction. Numerous kinases are involved in endocytosis, and each endocytic route is subjected to high-order regulation by cellular signaling mechanisms. In this study, we investigated whether ROCK and MLCK signaling cascades and G-proteins regulate the endocytosis of CF in marginal cells of the stria vascularis. Methods CF was infused into the cochlear duct with pertussis toxin (PTX),Clostridium botulinum C3 toxin (BTX), guanosine(g-thio)-triphosphate (GTP-γS), ML-7, Y-27632. Endocytic activity was measured at 30 min after the start of infusion under an electron microscope. Results In marginal cells, CF was internalized via a clathrin-mediated pathway that depends on F-actin and microtubules (MT). Its processes were controlled by myosin light chain kinase (MLCK) and Rho-associated kinase (ROCK), but not affected by G-protein-coupled receptor (GPCR) or the RhoA signaling cascade. Conclusion Our previous study showed that the main endocytotic pathway of microperoxidase (MPO) did not depend on the Rho/ROCK molecular switch or actin/myosin motor system, but was mainly regulated by the RhoA signaling cascade. The present study results indicate that these signaling cascades regulating CF internalization completely differ from the cascades for MPO internalization.
    Oct. 2019, Auris, nasus, larynx, 46(5) (5), 790 - 796, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 甲状腺乳頭癌の局所再発手術例の検討
    大月 直樹, 下田 光, 森田 成彦, 手島 直則, 丹生 健一
    (一社)日本内分泌外科学会, Sep. 2019, 日本内分泌外科学会雑誌, 36(Suppl.3) (Suppl.3), S324 - S324, Japanese

  • 【嚥下障害を診る!-プロに学ぶ実践スキル】病態と診断 超高齢社会における嚥下トリアージ
    上岡 美和, 古川 竜也, 丹生 健一
    (株)医学書院, Sep. 2019, 耳鼻咽喉科・頭頸部外科, 91(10) (10), 818 - 823, Japanese
    [Refereed]

  • 【命と機能を守る頭頸部がん診療】チーム医療としての頭頸部がん診療
    林 隆一, 丹生 健一, 松浦 一登, 西村 恭昌, 中塚 貴志
    (公社)日本医師会, Sep. 2019, 日本医師会雑誌, 148(6) (6), 1057 - 1070, Japanese
    [Refereed]

  • Chiaki Suzuki, Naomi Kiyota, Yoshinori Imamura, Hideaki Goto, Hirotaka Suto, Naoko Chayahara, Masanori Toyoda, Yasuhiro Ito, Akihiro Miya, Akira Miyauchi, Naoki Otsuki, Ken-Ichi Nibu, Hironobu Minami
    BACKGROUND: Multitarget kinase inhibitors (m-TKI), including lenvatinib, are now available as treatment options for radioiodine-refractory differentiated thyroid cancer (RR-DTC). However, the optimal timing of treatment initiation with m-TKI in these patients remains to be defined. METHODS: We retrospectively reviewed the clinical records of 30 consecutive patients with RR-DTC. The relationship between clinical characteristics was evaluated, including tumor growth parameters at pretreatment/post-treatment and efficacy of lenvatinib. RESULTS: A total of 26 patients with RR-DTC treated with lenvatinib were evaluable for response and eligible for analysis. From the results of multivariate analysis, baseline tumor size and tumor-related symptoms were independent negative prognostic factors for overall survival (OS) and progression-free survival (PFS). Pretreatment tumor growth parameters were not prognostic for either PFS or OS. CONCLUSIONS: Patients with RR-DTC with a high tumor burden and tumor-related symptoms had significantly worse prognosis. Greater tumor reduction after starting lenvatinib may lead to better prognosis, irrespective of pretreatment high tumor growth rate.
    Sep. 2019, Head & neck, 41(9) (9), 3023 - 3032, English, International magazine
    [Refereed]
    Scientific journal

  • Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.
    Sep. 2019, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu
    BACKGROUND: Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare. PATIENTS AND METHODS: We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases. RESULTS: Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. RPLN metastasis arose unilaterally in 15 patients and bilaterally in 1 patient. Eleven patients showed temporal dysphagia and four patients showed temporal vocal cord paralysis, but both symptoms eventually recovered in all cases. Two patients with salvage RPLN dissection died of distant metastasis and six patients survived with distant metastasis and/or persistent loco-regional disease. Other eight patients have been alive without disease. CONCLUSIONS: Although transcervical approach for RPLN metastases of PTC provided acceptable functional and oncological outcomes, half of the patients with RPLN metastasis have had distant metastasis and/or persistent locoregional disease. Indications of surgery for patients with RPLN metastasis need to be performed carefully in consideration of patients' prognosis and quality of life.
    Jun. 2019, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 276(6) (6), 1809 - 1814, English, International magazine
    [Refereed]
    Scientific journal

  • Masanori Teshima, Naoki Otsuki, Hirotaka Shinomiya, Naruhiko Morita, Tatsuya Furukawa, Koichi Morimoto, Tetsu Nakamura, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    OBJECTIVES: To evaluate the impact of retropharyngeal lymph node (RPLN) dissection in the surgical treatment of hypopharyngeal cancer. METHODS: Between 2007 and 2016, 98 previously untreated patients with pathological diagnosed hypopharyngeal squamous cell carcinoma underwent total pharyngolaryngectomy and bilateral neck dissection at Kobe University Hospital. Bilateral dissection of RPLN was simultaneously performed in all patients. Pharynx was reconstructed with free jejunal transfer in 94 patients and primarily closed in 4 patients. Postoperative chemoradiotherapy was performed in patients with high risk factors including metastasis to RPLN, multiple lymph node metastasis, extranodal invasion, and/or positive/close surgical margins. RESULTS: The median follow-up period was 25 months ranging from 1 to 105 months. RPLN adenopathy was preoperatively identified in 9 patients in FDG-positron emission tomography. All of them had pathologically diagnosed RPLN metastases, which had been controlled in all patients during the observation periods. Among the other 89 patients, 7 patients had RPLN metastasis. The 2-year overall survival rates of the patients with and without RPLN metastasis were 65.7% and 69.8% (P = .61), respectively. CONCLUSIONS: In the present study, patients with RPLN metastasis showed equally favorable oncological outcome compared with patients without RPLN metastasis. At least, ipsilateral RPLN dissection should be considered in the surgical treatment of advanced hypopharyngeal cancer and multiple neck lymph node metastasis regardless of primary subsite.
    Jun. 2019, Head & neck, 41(6) (6), 1738 - 1744, English, International magazine
    [Refereed]
    Scientific journal

  • Hisami Fujio, Go Inokuchi, Shun Tatehara, Shunsuke Kuroki, Yuriko Fukuda, Hisamoto Kowa, Ken-Ichi Nibu
    OBJECTIVES: Parkinson disease (PD) is frequently associated with olfactory disorder at early stage, which is caused by deposition of Lewy bodies emerging from the olfactory bulb to higher olfactory centers. Early detection of olfactory disorder in the patients with PD may lead to the early diagnosis and treatment for this refractory disease. METHODS: Visual analog scale (VAS), Jet Stream Olfactometry, and Japanese smell identification test, Open Essence (OE), were carried out on 39 patients with PD. Thirty-one patients with postviral olfactory disorder (PVOD), which was caused by the olfactory mucosal dysfunction, were also enrolled in this study as control. RESULTS: There were no significant differences in detection thresholds (2.2 vs. 1.4, P=0.13), recognition thresholds (3.9 vs. 3.5, P=0.39) and OE (4.8 vs. 4.2, P=0.47) between PVOD and PD, while VAS scores of PVOD and PD were significantly different (2.0 and 6.2, P<0.01). In OE, significant differences were observed in the accuracy rates of menthol (68% vs. 44%, P=0.04) and Indian ink (42% vs. 15%, P=0.01) between PVOD and PD. Of particular interest, patients with PVOD tended to select "no detectable," while patients with PD tended to select wrong alternative other than "no smell detected." CONCLUSION: Discrepancy between VAS and OE, and high selected rates of wrong alternative other than "undetectable" in OE might be significant signs of olfactory dysfunction associated with PD.
    Korean Society of Otorhinolaryngology-Head and Neck Surgery, May 2019, Clinical and experimental otorhinolaryngology, 12(2) (2), 206 - 211, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 【救急・当直マニュアル-いざというときの対応法】救急外来・当直での心得と準備 救急外来での心得と準備
    丹生 健一
    (株)医学書院, Apr. 2019, 耳鼻咽喉科・頭頸部外科, 91(5) (5), 8 - 9, Japanese
    [Refereed]

  • 頭頸部がんの最適化医療 根治とQOLの両立を目指して
    丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 371 - 374, Japanese

  • Tatsuya Furukawa, Hirokazu Komatsu, Hisami Fujio, Yasutaka Kojima, Naruhiko Morita, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naoki Otsuki, Makoto Kano, Ken-Ichi Nibu
    Background: In 2008, Kano developed a new laryngeal closure technique (Kano's method) for the treatment of severe aspiration. The aim of this study was to evaluate the safety and efficacy of this technique in patients with head and neck cancer. Methods: Since June 2014 until March 2018, six patients underwent Kano's method for management of severe aspiration after the treatment of head and neck cancers. The anterior parts of the thyroid and the cricoid cartilages were excised widely. The glottis was closed by suturing bilateral vocal folds and reinforced by the sternohyoid muscle. A tracheostoma was created with skin flaps, subglottic mucosal flaps, and stumps of cricoid and trachea cartilages. Results: No severe complications were observed after the surgery. Oral intake improved without developing aspiration. Conclusions: Kano's method can provide satisfactory functional results with minimal invasion for treating severe aspiration after advanced surgery, chemotherapy, and/or chemoradiotherapy, in patients with head and neck cancer. Level of Evidence: 4.
    Apr. 2019, Laryngoscope investigative otolaryngology, 4(2) (2), 246 - 249, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-Ichi Nibu, Seiichi Yoshimoto, Taisuke Mori
    BACKGROUND: Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can confound efforts to identify malignancies. Similar to BRAF, cyclin D1 may be a strong marker of cell proliferation. METHODS: One hundred two patients with thyroidal nodule were enrolled in this prospective study. Expression of cyclin D1 in thyroid nodules was determined by immunohistochemistry using both surgical specimens and their cytological specimens. The identification of the optimal cut off points for the diagnosis of malignancy were evaluated using the receiver operating characteristic (ROC) curves and the assessment of the area under the ROC curve (AUC). The specificity, sensitivity, positive predictive value (PPV) of markers were evaluated from crosstabs based on cut off points and significance were calculated. We also analyzed genetic variants by target NGS for thyroid nodule samples. RESULTS: The positive predictive value (PPV) and median stain ratio (MSR) of cyclin D1 nuclear staining was determined in papillary thyroid carcinoma (PPV = 91.5%, MSR = 48.5%), follicular adenoma (PPV = 66.7%, MSR = 13.1%), and adenomatous goiter and inflammation controls (MSR = 3.4%). In FNA samples, a threshold of 46% of immunolabelled cells allows to discriminate malignant lesions from benign ones (P < 0.0001), with 81% sensitivity and 100% specificity. A 46% cutoff value for positive cyclin D1 immunostaining in thyroid cells demonstrated 81% sensitivity and 100% specificity. In surgical specimens, ROC curve analysis showed a 5.8% cyclin D1 immunostaining score predicted thyroid neoplasms at 94.4% sensitivity and 92.3% specificity (P = 0.003), while a 15.7% score predicted malignancy at 86.4% sensitivity and 80.5% specificity (P < 0.0001). Finally, three tested clinico-pathological variables (extra thyroidal extension, intraglandular metastasis, and lymph node metastasis) were significant predictors of cyclin D1 immunostaining (P < 0.001). CONCLUSION: Our cytological cyclin D1 screening system provides a simple, accurate, and convenient diagnostic method in precision medicine enabling ready determination of personalized treatment strategies for patients by next generation sequencing using cytological sample.
    Mar. 2019, BMC cancer, 19(1) (1), 245 - 245, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasuyuki Kajimoto, Naoki Otsuki, Masanori Teshima, Yukiko Morinaga, Tomoo Itoh, Ken-Ichi Nibu
    Informa {UK} Limited, Jan. 2019, Acta Oto-Laryngologica Case Reports, 4(1) (1), 26 - 29
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hideaki Goto, Naomi Kiyota, Naoki Otsuki, Yoshinori Imamura, Naoko Chayahara, Hirotaka Suto, Yoshiaki Nagatani, Masanori Toyoda, Toru Mukohara, Ken-Ichi Nibu, Toshihiko Kasahara, Yasuhiro Ito, Akihiro Miya, Mitsuyoshi Hirokawa, Akira Miyauchi, Hironobu Minami
    Sorafenib and lenvatinib showed efficacy for patients with radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) in pivotal phase 3 clinical trials. Although the efficacy of lenvatinib in patients who received previous treatment with multi-target kinase inhibitors (m-TKIs), including sorafenib, was reported, the efficacy of sorafenib in patients who previously received lenvatinib remains unknown. A 75-year-old woman diagnosed as RAI-refractory poorly differentiated carcinoma with multiple lung metastases and started treatment with lenvatinib. She continued to receive lenvatinib but with repeated dose interruptions and reductions due to continuous proteinuria. Because of severe and persistent proteinuria as well as newly developed renal impairment, lenvatinib was suspended after two years of treatment. After the 7-month suspension, her proteinuria and renal impairment were partially improved, but her lung metastases progressed. Because she was unable to tolerate previous treatment with lenvatinib, sorafenib was started. At 7 months of treatment with sorafenib, her lung metastases shrank and she could continue sorafenib without exacerbation of proteinuria or renal impairment. This case may suggest that sorafenib does not exacerbate the proteinuria or renal impairment induced by lenvatinib, and may be an effective treatment option for RAI-refractory DTC patients who are unable to tolerate lenvatinib.
    Dec. 2018, Auris, nasus, larynx, 45(6) (6), 1249 - 1252, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Miki Takahashi, Nana Kosaka, Emi Wakui, Shinobu Iwaki, Mika Nishii, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naomi Kiyota, Ryohei Sasaki, Makoto Usami, Naoki Otsuki, Ken-Ichi Nibu
    BACKGROUND: Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT. PATIENTS AND METHODS: Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group. RESULTS: INS in addition to PEG significantly increased calorie intake in the second half of CCRT and reduced adverse events including mucositis (p = 0.0019), leukopenia (p = 0.04), and renal function (p = 0.006). Moreover, 21 out of 29 patients had successfully administration of 200 mg/m2 or more of CDDP, while only 10 out of 29 patients had enough amount of CDDP in control group. CONCLUSIONS: These results suggest that INS in addition to prophylactic PEG not only decreases adverse effects but also may potentially improve oncological outcome of the patients with oropharyngeal cancer treated by CCRT.
    Dec. 2018, International journal of clinical oncology, 23(6) (6), 1023 - 1028, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoshihide Okumura, Takayuki Murase, Kosuke Saida, Kana Fujii, Hisashi Takino, Ayako Masaki, Kei Ijichi, Kazuo Shimozato, Yuichiro Tada, Ken-Ichi Nibu, Hiroshi Inagaki
    BACKGROUND: The National Comprehensive Cancer Network (NCCN) guidelines recommend considering postoperative radiotherapy (PORT) for completely resected T1/2N0M0 salivary mucoepidermoid carcinomas when they show tumor spillage, perineural invasion, or intermediate/high-grade histology. CRTC1/3-MAML2 fusions have been associated with a favorable clinical outcome. METHODS: Forty-seven T1/2N0M0 mucoepidermoid carcinoma cases positive for CRTC1/3-MAML2 fusions were completely resected and were not treated with PORT. RESULTS: Pathologically, none of the cases showed tumor spillage or perineural invasion. Cases with intermediate/high-grade histology numbered 9 (19%) to 26 (55%) with the currently used 3 different grading systems. During the follow-up (median 60 months), locoregional tumor recurrence occurred in 4 cases, which were treated with surgery alone. At the last follow-up (median 60 months; 7-160), all patients were alive with no evidence of disease. CONCLUSION: An excellent prognosis may be achieved without PORT in T1/2N0M0 mucoepidermoid carcinoma patients positive for CRTC1/3-MAML2 fusions when the tumors are completely resected without tumor spillage.
    Dec. 2018, Head & neck, 40(12) (12), 2565 - 2573, English, International magazine
    [Refereed]
    Scientific journal

  • Masanori Teshima, Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu
    OBJECTIVES: Postoperative hypoparathyroidism (HPT) is one of the most common complications in total thyroidectomy for thyroid carcinoma. Parathyroid glands (PTGs) are at risk of being damaged during total thyroidectomy and central neck dissection mainly due to inadvertent removal, interruption of the blood supply or hematoma formation. The purpose of this study was to evaluate the efficacy of our surgical procedure to preserve for parathyroid function retrospectively and to clarify the risk factors of HPT after total thyroidectomy for thyroid cancer. PATIENTS AND METHODS: Sixty-five patients undergoing total thyroidectomy with central neck dissection for thyroid cancer were enrolled in this retrospective study. Cancers were diagnosed as stage I in 15 patients, stage II in 24 patients, stage III in 19 patients, and stage IV in 7 patients. Lateral neck dissection and upper mediastinal dissection were simultaneously performed in 47 patients and one patient, respectively. Parathyroid glands (PTGs) were preserved in situ in 34 patients. Among 31 patients in whom PTG could not be preserved in situ, two or more PTGs were autotransplanted in 9 patients and one PTG was autotransplanted in 18 patients. PTG was not autotransplanted in 4 patients, since it could not be identified during the surgery. RESULTS: Postoperative transient HPT and permanent HPT were observed in 44 (68%) patients and in 12 (18%) patients, respectively. Among 34 patients in whom PTGs were preserved in situ, transient HPT and permanent HPT were observed in 17 (50%) patients and in 6 (2%) patients, respectively. Among 31 patients in whom PTG were not preserved in situ, postoperative permanent HPT was observed in all 4 patients without PTG autotransplantation, and 6 (33%) out of the 18 patients who had one PTG autotransplantation. On the other hand, none of the 9 patients who had two or more PTG autotransplantation at the time of thyroidectomy developed permanent HPT (P=0.04). The patients with large tumor (≥40mm) and/or gross extra glandular invasion had a significantly higher risk of permanent postoperative HPT compared with the patients without these pathological features (P<0.01). CONCLUSIONS: Two or more PTG should be autotransplanted in case where PTG is not preserved in situ to prevent postoperative HPT after total thyroidectomy with central neck dissection, especially in cases of large tumor and/or gross extrathyroidal extension.
    Dec. 2018, Auris, nasus, larynx, 45(6) (6), 1233 - 1238, English, International magazine
    [Refereed]
    Scientific journal

  • Yuriko Fukuda, Sayaka Katsunuma, Atsuhiro Uranagase, Jumpei Nota, Ken-Ichi Nibu
    In the mammalian olfactory epithelium (OE), neurogenesis continues throughout the lifetime, by replacing olfactory receptor neurons (ORNs) lost by normal turnover in the postnatal period. However, this ability decreases with age and/or because of various toxic factors. To date, no effective treatment for olfactory dysfunction' especially because of aging, is available in clinical practice. Here, we examined the effects of intranasal administration of fibroblast growth factor-2 and insulin-like growth factor-1 in gelatin hydrogel on the degenerated OE of aging mice induced by methimazole administration. These topical treatments led to increases in the number of olfactory marker protein-positive cells, which identified mature ORNs, resulting in the increased thickness of OE. These results indicate that both fibroblast growth factor-2 and insulin-like growth factor-1 promote the proliferation of basal cells and differentiation of immature ORNs into mature ORNs in the degenerated OE of aging mice. These agents might be promising candidates for the treatment of degenerated OE of aging humans.
    Nov. 2018, Neuroreport, 29(16) (16), 1400 - 1404, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hyogo Y, Kiyota Naomi, Ohtsuki Naoki, Goto Shunsuke, Imamura Yoshinori, Chayahara N, Toyoda Masanori, Nibu Ken-ichi, Hyodo T, Hara S, Masuoka H, Kasahara T, Ito Y, Miya A, Hirokawa M, Miyauchi A, Minami Hironobu
    Nov. 2018, Case Rep Oncol, 11(3) (3), 735 - 741, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • A case of nasopharyngeal clear cell carcinoma diagnosed by molecular analysis
    Hara M, Otuski N, Yanagisawa S, Kokan N, Fujio H, Shinomiya H, Morita N, Hara S, Inagaki H, Niibu K
    Oct. 2018, Acta Oto-Laryngologica Case Reports, 3(1) (1), 34 - 38, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 研究者の最新動向 制限増殖型アデノウイルスベクターを用いた頭頸部癌に対する新たな治療法の開発
    Uehara Natsumi, Nibu Ken-ichi
    Oct. 2018, Precision Medicine, 1(1号) (1号), 93 - 97, Japanese
    [Refereed][Invited]
    Scientific journal

  • Chisato Mogi, Hirotaka Shinomiya, Natsumi Fujii, Tomoyuki Tsuruta, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Maki Kanzawa, Mitsuyoshi Hirokawa, Naoki Otsuki, Ken-Ichi Nibu
    Carcinoma arising in lingual thyroid is an extremely rare entity accounting for only 1% of all reported ectopic thyroids. Here, we report a case of carcinoma arising in lingual thyroid, which has been successfully managed by transoral resection and bilateral neck dissections. A lingual mass 4-cm in diameter with calcification was incidentally detected by computed tomography at medical check-up. No thyroid tissue was observed in normal position. Ultrasound examination showed bilateral multiple lymphadenopathies. Fine needle aspiration biopsy from lymph node in his right neck was diagnosed as Class III and thyroglobulin level of the specimen was 459ng/ml. Due to the difficulty in performing FNA of the lingual masses, right neck dissection was performed in advance for diagnostic purpose. Pathological examination showed existence of large and small follicular thyroid tissues in several lymph nodes, suggesting lymph node metastasis from thyroid carcinoma. Two months after the initial surgery, video-assisted transoral resection of lingual thyroid with simultaneous left neck dissection was performed. Postoperative course was uneventful. Papillary carcinoma was found in the lingual thyroid and thyroid tissues were also found in left cervical lymph nodes. Video-assisted transoral resection was useful for the treatment of thyroid cancer arising in lingual thyroid.
    Oct. 2018, Auris, nasus, larynx, 45(5) (5), 1127 - 1129, English, International magazine
    [Refereed]
    Scientific journal

  • Yasutaka Kojima, Naoki Otsuki, Mie Kubo, Junko Kitamoto, Eri Takata, Hiroki Saito, Kyoko Kosaka, Naoya Morishita, Natsumi Uehara, Toshiro Shirakawa, Ken-Ich Nibu
    Human papillomavirus (HPV) infection has been identified as an etiologic factor of head and neck cancers (HNCs). We explored the potential use of antisense HPV RNA transcripts for gene therapy and its effect in combination with cisplatin (CDDP) for HPV-positive HNCs. We introduced the antisense RNA transcripts of the E6 and E7 genes of HPV type 16 into UM-SCC-47 cells harboring HPV 16 and YCU-T892 cells that were HPV-negative using a recombinant adenoviral vector, Ad-E6/E7-AS. We then analyzed the effects of the introduction of Ad-E7-AS on cell and tumor growth and the synergistic effect with CDDP in vitro and in vivo. After infection of Ad-E6/E7-AS, the cellular growth of UM-SCC-47 cells were suppressed, but not that of YCU-T892 cells. E7 protein expression was suppressed, and p53 and pRb protein expression increased after infection of Ad-E7-AS. Cell growth and tumorigenicity were greatly suppressed in combination with CDDP compared with Ad-E7-AS or CDDP treatment alone in vitro. Ad-E7-AS combined with CDDP treatment significantly reduced the volumes of established subcutaneous tumors. Transfection with HPV 16 E7 antisense RNA combined with CDDP treatment might be a potentially useful approach to the therapy of HPV 16-positive HNC.
    Oct. 2018, Cancer gene therapy, 25(9-10) (9-10), 274 - 283, English, International magazine
    [Refereed]
    Scientific journal

  • Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Hidehito Kimura, Masaaki Taniguchi, Kazunobu Hashikawa, Eiji Kohmura, Ken-Ichi Nibu
    Objective  Nasal and paranasal malignant tumors invading the skull base are rare and poorly studied. We evaluated postoperative complications in patients undergoing salvage surgery for such tumors. Design  Retrospective study. Setting  Kobe University Hospital. Participants  Among 48 patients who underwent surgery for tumors involving the skull base between 1993 and 2015, 21 patients had squamous cell carcinoma, 13 had olfactory neuroblastoma, 5 had adenocarcinoma, 2 had sarcoma, 2 had adenoid cystic carcinoma, and 1 each had malignant melanoma, poorly differentiated carcinoma, undifferentiated carcinoma, myoepithelial carcinoma, and malignant peripheral nerve sheath tumor. Prior to skull base surgery, radiotherapy, chemoradiotherapy (CRT), particle radiotherapy, chemotherapy, or surgery were applied in 3, 15, 4, 5, and 3 patients, respectively. Main Outcome Measures  Main outcome measures were postoperative complications in patients who underwent skull base surgery after concomitant CRT and/or particle therapy. Results  Major postoperative complications were observed in 14 surgical procedures (29%; 2 patients with cerebral herniation, 3 with cerebrospinal fluid leakages, 3 with meningitis, 1 with hydrocephalus, 6 with epidural abscesses, 2 with local infections, and 2 with partial flap necrosis). Four patients developed ≥2 complications. One patient died of postoperative lung infarction. Three (16.7%) of 18 patients without prior treatment and 9 (50%) of 18 patients who underwent preoperative radiotherapy/CRT had severe postoperative complications. Two (50%) of four patients treated with particle radiotherapy had postoperative complications. Conclusions  CRT or particle radiotherapy were significantly associated with a high risk of severe postoperative complications after skull base surgery. Meticulous care should be taken in patients treated with radiotherapy/particle therapy prior to skull base surgery.
    Jun. 2018, Journal of neurological surgery. Part B, Skull base, 79(3) (3), 224 - 228, English, International magazine
    [Refereed]
    Scientific journal

  • Özgür Mehmet Avinçsal, Hirotaka Shinomiya, Naoki Otsuki, Ryohei Sasaki, Ken-ichi Nibu
    Background: Aggressive fibromatoses are histologically benign fibrous neoplasms originating from musculoaponeurotic structures throughout the body. They are locally invasive and erode adjacent vital structures. The head and neck region constitutes 7-25% of all extra-abdominal cases. Case Report: Here, we report the case of a patient with aggressive fibromatosis in the left side of the neck. While the tumor deeply invaded the scalene muscles, the lesion was successfully treated by surgery followed by radiotherapy. The patient has been disease free for the last 7 years following treatment. Conclusion: Due to its unusual location in the head and neck region, aggressive fibromatosis should be considered in the differential diagnosis of invading lesions of the neck.
    May 2018, Balkan medical journal, 35(3) (3), 278 - 281, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 次世代シーケンサーを用いたHPV陽性およびHPV陰性中咽頭癌の遺伝子解析 頭頸部癌基礎研究会報告
    家根 旦有, 藤井 正人, 太田 一郎, 菅澤 正, 本間 明宏, 水田 啓介, 倉富 勇一郎, 丹生 健一, 加藤 久幸, 大上 研二, 北村 守正, 辻 裕之, 安松 隆治, 永澤 昌
    (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 125 - 125, Japanese

  • 次世代シーケンサーを用いたHPV陽性およびHPV陰性中咽頭癌の遺伝子解析 頭頸部癌基礎研究会報告
    家根 旦有, 藤井 正人, 太田 一郎, 菅澤 正, 本間 明宏, 水田 啓介, 倉富 勇一郎, 丹生 健一, 加藤 久幸, 大上 研二, 北村 守正, 辻 裕之, 安松 隆治, 永澤 昌
    (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 125 - 125, Japanese

  • Modified TALK Score for Japanese Patients with Laryngeal and Hypopharyngeal Cancers to Predict the Possibility of Laryngeal Preservation by Concurrent Chemoradiotherapy.
    Naoki Otsuki, Mio Matsui, Miki Takahashi, Ryohei Sasaki, Naomi Kiyota, Makoto Usami, Ken-Ichi Nibu
    OBJECTIVE: TALK score has been developed as an index for predicting the possibility of larynx preservation and prognosis of the patients with advanced laryngeal and hypopharyngeal cancers treated by concurrent chemoradiotherapy (CCRT). In this study, we validated the original TALK score in our clinical setting and modified the score for Japanese population. METHODS: The subjects were 21 patients with laryngeal cancer and 50 patients with hypopharyngeal cancer who underwent CCRT at Kobe University Hospital between April 2007 and August 2012. Data regarding T stage, serum albumin level just before treatment, maximum alcohol use, Karnofsky Performance Status (KPS), 3-year overall survival rate and 3-year larynx-preservation rate were collected from medical records. In the revised TALK score (JTALK), the following scoring criteria were modified to adjust Japanese population: T stage of the primary tumor (≥T3), serum albumin level (<3.5 g/dl), maximum alcohol use (≥one 350-ml can of beer/day or an equivalent amount), and KPS (<80%). RESULTS: The original TALK score was not significantly associated with the larynx preservation rates or survival rates for laryngeal cancer or hypopharyngeal cancer. Instead, JTALK score was significantly associated with the 3-year larynx preservation rates and 3-year survival rates of the patients with hypopharyngeal and laryngeal cancer. CONCLUSION: These results indicate that JTALK score could be a useful index for predicting the possibility of larynx preservation and prognosis of Japanese patients with advanced laryngeal and hypopharyngeal cancer treated by CCRT.
    Apr. 2018, The Kobe journal of medical sciences, 63(4) (4), E113-E122 - E122, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Naoki Sawada, Takenori Kotani, Tasuku Konno, Jajar Setiawan, Yuka Nishigaito, Yasuyuki Saito, Yoji Murata, Ken-Ichi Nibu, Takashi Matozaki
    In the mouse olfactory bulb (OB), interneurons such as granule cells and periglomerular cells are continuously replaced by adult-born neurons, which are generated in the subventricular zone (SVZ) of the brain. We have now investigated the role of commensal bacteria in regulation of such neuronal cell turnover in the adult mouse brain. Administration of mixture of antibiotics to specific pathogen-free (SPF) mice markedly attenuated the incorporation of bromodeoxyuridine (BrdU) into the SVZ cells. The treatment with antibiotics also reduced newly generated BrdU-positive neurons in the mouse OB. In addition, the incorporation of BrdU into the SVZ cells of germ-free (GF) mice was markedly reduced compared to that apparent for SPF mice. In contrast, the reduced incorporation of BrdU into the SVZ cells of GF mice was recovered by their co-housing with SPF mice, suggesting that commensal bacteria promote the incorporation of BrdU into the SVZ cells. Finally, we found that administration of ampicillin markedly attenuated the incorporation of BrdU into the SVZ cells of SPF mice. Our results thus suggest that ampicillin-sensitive commensal bacteria regulate the neurogenesis in the SVZ of adult mouse brain.
    Apr. 2018, Biochemical and biophysical research communications, 498(4) (4), 824 - 829, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mehmet Ozgur Avincsal, Naoe Jimbo, Kohei Fujikura, Hirotaka Shinomiya, Naoki Otsuki, Koichi Morimoto, Tatsuya Furukawa, Naruhiko Morita, Ritsuko Maehara, Tomoo Itoh, Ken-Ichi Nibu, Yoh Zen
    AIMS: We recently reported that a small subset (7%) of oesophageal squamous cell carcinomas completely lacking SOX2 expression had unique clinicopathological features and a dismal prognosis. The aim of the present study was to elucidate whether the findings obtained in oesophageal cancers are applicable to hypopharyngeal squamous cell carcinomas (HPSCCs) or oropharyngeal squamous cell carcinomas (OPSCCs). METHODS AND RESULTS: The study cohort consisted of consecutive patients with HPSCC (n = 130) and OPSCC (n = 65) who underwent surgery without preoperative therapy. On immunostaining, SOX2 was almost entirely negative in 10 of 130 HPSCCs (8%) and seven of 65 OPSCCs (11%). No significant differences were observed in clinicopathological features, including p16 status, between SOX2-positive and SOX2-negative cancers. However, patients with SOX2-negative HPSCC had significantly worse overall and recurrence-free survival than those with SOX2-positive HPSCC, whereas such a prognostic relationship was not confirmed in patients with OPSCC. In a multivariate analysis, the loss of SOX2 expression appeared to be an independent poor prognostic factor for patients with HPSCC. In a sequencing analysis, no mutation was found in SOX2. As SOX2 is known to contain an extensive CpG island before the transcription start site, methylation-specific polymerase chain reaction for the SOX2 promoter was performed. Methylated alleles were found in nine of 10 SOX2-negative HPSCCs but in none of SOX2-positive HPSCCs. CONCLUSIONS: Similarly to oesophageal cancers, a small subset (8%) of HPSCCs characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing.
    Apr. 2018, Histopathology, 72(5) (5), 826 - 837, English, International magazine
    [Refereed]
    Scientific journal

  • Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun Miyaguchi, Shin-Ichi Oikawa, Kodai Tsuchida, Takahiro Asakage, Hiroyuki Ozawa, Ken-Ichi Nibu, Naoki Ohtsuki, Yasushi Fujimoto, Ken-Ichi Kaneko
    There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46.1 months. Eighteen patients had a family history of paragangliomas and fifteen patients had bilateral CBTs. Among the 94 patients who underwent surgery to remove a CBT, 23 patients had tumors classified as Shamblin type I, 59 had type II and 12 had type III. The most frequent feeding artery of these CBTs was the ascending pharyngeal artery. Preoperative embolization of these arteries was effective in reducing blood loss; however, the operation time in Shamblin type I and II tumors was not improved. Thus these results revealed the status of patients with CBT and their treatment throughout Japan.
    Apr. 2018, Oncology letters, 15(4) (4), 5318 - 5324, English, International magazine
    [Refereed]
    Scientific journal

  • Mehmet Ozgur Avinçsal, Hirotaka Shinomiya, Masanori Teshima, Mie Kubo, Naoki Otsuki, Naomi Kyota, Ryohei Sasaki, Yoh Zen, Ken-Ichi Nibu
    BACKGROUND: The purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival. METHODS: We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B-ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well-known clinical risk factors into account. RESULTS: Heavy drinkers with ALDH2*2 allele resulted in significantly worse overall survival (OS; P = .028) and disease-free survival (DFS; P = .029) compared with other patients. Heavy drinkers with ALDH2*2 allele remained statistically significant in multivariate analysis for OS and DFS, indicating independent poor prognostic factor (hazard ratio [HR] 2.251; 95% confidence interval [CI] 1.018-4.975 and HR 2.261; 95% CI 1.021-5.006, respectively). CONCLUSION: We conclude that heavy drinkers with the ALDH2*2 allele are associated with poor outcome in hypopharyngeal SCC.
    Apr. 2018, Head & neck, 40(4) (4), 770 - 777, English, International magazine
    [Refereed]
    Scientific journal

  • Kosuke Saida, Takayuki Murase, Mayuko Ito, Kana Fujii, Hisashi Takino, Ayako Masaki, Daisuke Kawakita, Kei Ijichi, Yuichiro Tada, Kimihide Kusafuka, Yoshiyuki Iida, Tetsuro Onitsuka, Yasushi Yatabe, Nobuhiro Hanai, Yasuhisa Hasegawa, Hitomi Shinomiya, Ken-Ichi Nibu, Kazuo Shimozato, Hiroshi Inagaki
    Adenoid cystic carcinoma (AdCC), one of the most common salivary gland carcinomas, usually has a fatal outcome. Epidermal growth factor receptor (EGFR) pathway gene mutations are important in predicting a patient's prognosis and estimating the efficacy of molecular therapy targeting the EGFR pathway. In this study of salivary gland AdCC (SAdCC), we looked for gene mutations in EGFR, RAS family (KRAS, HRAS, and NRAS), PIK3CA, BRAF, and AKT1, using a highly sensitive single-base extension multiplex assay, SNaPshot. Out of 70 cases, EGFR pathway missense mutations were found in 13 (18.6%): RAS mutations in 10 (14.3%), EGFR in one (1.4%), and PIK3CA in 5 (7.1%). None of the cases showed an EGFR deletion by direct sequencing. Concurrent gene mutations were found in three cases (4.3%). EGFR pathway mutations were significantly associated with a shorter disease-free (p = 0.011) and overall survival (p = 0.049) and RAS mutations were as well; (p = 0.010) and (p = 0.024), respectively. The gene fusion status as determined by a FISH assay had no significant association with mutations of the genes involved in the EGFR pathway. In conclusion, EGFR pathway mutations, especially RAS mutations, may be frequent in SAdCC, and associated with a poor prognosis for the patient.
    Mar. 2018, Oncotarget, 9(24) (24), 17043 - 17055, English, International magazine
    [Refereed]
    Scientific journal

  • Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun Miyaguchi, Shin-Ichi Oikawa, Kodai Tsuchida, Takahiro Asakage, Takahiro Ozawa, Ken-Ichi Nibu, Naoki Ohtsuki, Yasushi Fujimoto, Ken-Ichi Kaneko
    Spandidos Publications, Mar. 2018, Oncology Letters, 15(3) (3), 3383 - 3389, English
    [Refereed]
    Scientific journal

  • Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito
    Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion. Hyalinizing clear cell carcinoma is a low-grade tumor with infrequent nodal and distant metastasis, recently shown to harbor an EWSR1-ATF1 gene fusion. The CRTC1-MAML2 fusion gene resulting from a t(11;19)(q21;p13) translocation, is now known to be a feature of both low-grade and high-grade mucoepidermoid carcinomas associated with improved survival. A t(6;9)(q22-23;p23-34) translocation resulting in a MYB-NFIB gene fusion has been identified in the majority of adenoid cystic carcinomas. Polymorphous (low-grade) adenocarcinoma and cribriform adenocarcinoma of (minor) salivary gland origin are related entities with partly differing clinicopathologic and genomic profiles; they are the subject of an ongoing taxonomic debate. Polymorphous (low-grade) adenocarcinomas are characterized by hot spot point E710D mutations in the PRKD1 gene, whereas cribriform adenocarcinoma of (minor) salivary glands origin are characterized by translocations involving the PRKD1-3 genes. Salivary duct carcinoma (SDC) is a high-grade adenocarcinoma with morphologic and molecular features akin to invasive ductal carcinoma of the breast, including HER2 gene amplification, mutations of TP53, PIK3CA, and HRAS and loss or mutation of PTEN. Notably, a recurrent NCOA4-RET fusion has also been found in SDC. A subset of SDC with apocrine morphology is associated with overexpression of androgen receptors. As these genetic aberrations are recurrent they serve as powerful diagnostic tools in salivary gland tumor diagnosis, and therefore also in refinement of salivary gland cancer classification. Moreover, they are promising as prognostic biomarkers and targets of therapy.
    Feb. 2018, The American journal of surgical pathology, 42(2) (2), e11-e27 - e27, English, International magazine
    [Refereed]
    Scientific journal

  • Hirotaka Yamamoto, Atsushi Fujita, Taichiro Imahori, Takashi Sasayama, Kohkichi Hosoda, Ken-Ichi Nibu, Eiji Kohmura
    Focal hyperintensity (FHI) in the dorsal brain stem on T2-weighted images of patients with cerebellopontine angle (CPA) tumor was thought to indicate degeneration of the vestibular nucleus and to be specific to vestibular schwannoma. The purpose of this study was to evaluate FHI by using high-resolution 3 Tesla magnetic resonance imaging (3 T MRI) and the relation to clinical characteristics. We retrospectively reviewed the clinical data and MRI of 45 patients with CPA tumors (34 vestibular schwannomas and 11 other tumors). FHI in the dorsal brain stem was found in 25 (55.6%) patients (20 vestibular schwannomas and 5 other tumors). For the vestibular schwannomas, the factors contributing to positive FHI were age (p = 0.025), max CPA (p =  < 0.001), hearing ability (P = 0.005), and canal paresis (p =  < 0.001) in the univariate analysis. Multivariate regression analysis showed that max CPA (p = 0.029) was a significant factor of positive FHI. In other CPA tumors, these factors were not significant predictors. With the use of 3 T MRI, FHI was observed more frequently than previously reported. Our results suggest that FHI is not a specific indicator of vestibular schwannoma and is related to not only vestibular function but also other factors.
    Jan. 2018, Scientific reports, 8(1) (1), 881 - 881, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 萩田 萌, 涌井 絵美, 岩城 忍, 横井 純, 四宮 弘隆, 森本 浩一, 丹生 健一
    日本音声言語医学会, Jan. 2018, 音声言語医学, 59(1) (1), 89 - 89, Japanese

  • Fujio Kumi, Inokuchi Gou, 福田有里子, 黒木俊介, 古閑紀雄, 丹生健一
    Jan. 2018, 日本耳鼻咽喉科学会雑誌, 121(1) (1), 38 - 43, Japanese
    [Refereed]
    Research institution

  • Shigemichi Iwae, Masato Fujii, Ryuichi Hayashi, Yasuhisa Hasegawa, Takashi Fujii, Kenji Okami, Akihiro Homma, Tetsuro Onitsuka, Takakuni Kato, Takenori Ogawa, Kyoichi Terao, Nobuya Monden, Naoki Otsuki, Hiroshi Nishino, Ichiro Ota, Yasushi Fujimoto, Kazuto Matsuura, Kazuyoshi Kawabata, Hidetoshi Matsui, Koichiro Yonezawa, Ken-Ichi Nibu
    BACKGROUND: The aim of this study was to compare the therapeutic outcomes of total pharyngolaryngectomy with those of concomitant chemoradiotherapy in advanced hypopharyngeal cancer. METHODS: This is a retrospective multi-institutional study. The medical records of 979 patients with hypopharyngeal cancer, who were initially treated between 2006 and 2008, were reviewed. In this study, we matched a group of total pharyngolaryngectomy patients with a second group of chemoradiotherapy patients, according to age, gender, subsite, arytenoid fixation, cartilage invasion, and N classification, and analyzed overall survival, disease-specific survival, and locoregional control rates. RESULTS: The matched-pair analysis included 254 patients. The 5-year overall survival, disease-specific survival, and locoregional control rates were 58.5% and 53.5% (P = 0.30), 68.9% and 68.0% (P = 0.80), and 82.2% and 63.6% (P < 0.01), respectively, for patients in the total pharyngolaryngectomy and chemoradiotherapy groups. For T4a patients with cartilage invasion, the matched-pair analysis included 46 patients. The 5-year overall survival, disease-specific, and locoregional control rates were 56.5% and 26.0% (P = 0.092), 56.5% and 41.3% (P = 0.629), and 43.0% and 42.5% (P = 0.779), respectively, for patients in the total pharyngolaryngectomy and chemoradiotherapy groups. CONCLUSIONS: The data from this large-scale multi-institutional joint research program of hypopharyngeal cancer in Japan suggest that chemoradiotherapy may provide adequate survival benefit for hypopharyngeal cancer patients with the distinct advantage of larynx preservation. Our data also suggest that chemoradiotherapy is as beneficial as total pharyngolaryngectomy for the local control of locally advanced hypopharyngeal cancer.
    Dec. 2017, International journal of clinical oncology, 22(6) (6), 1001 - 1008, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 甲状腺癌縦隔進展例に対するアプローチの検討
    森田 成彦, 手島 直則, 大月 直樹, 丹生 健一
    日本内分泌外科学会・日本甲状腺外科学会, Oct. 2017, 日本内分泌・甲状腺外科学会雑誌, 34(Suppl.2) (Suppl.2), S282 - S282, Japanese

  • Ken-Ichi Nibu, Ryuichi Hayashi, Takahiro Asakage, Hiroya Ojiri, Yoshihiro Kimata, Takeshi Kodaira, Toshitaka Nagao, Torahiko Nakashima, Takashi Fujii, Hirofumi Fujii, Akihiro Homma, Kazuto Matsuura, Nobuya Monden, Takeshi Beppu, Nobuhiro Hanai, Tadaaki Kirita, Yuzuru Kamei, Naoki Otsuki, Naomi Kiyota, Sadamoto Zenda, Ken Omura, Koichi Omori, Tetsuo Akimoto, Kazuyoshi Kawabata, Seiji Kishimoto, Hiroya Kitano, Iwai Tohnai, Takashi Nakatsuka
    OBJECTIVE: The first revision of "Japanese Clinical Practice Guideline for Head and Neck Cancer" was made in 2013 by the clinical practice guideline committee of Japan Society for Head and Neck Cancer, in response to the revision of the TNM classification. METHODS: 34 CQs (Clinical Questions) were newly adopted to describe the diagnosis and treatment methods currently considered most appropriate, and offered recommendation grade made by the consensus of the committee. A comprehensive literature search was performed for studies published between 2001 and 2012 using PubMed. Qualified studies were analyzed and the results were evaluated, consolidated and codified by all the committee members. RESULTS: Elective neck dissection (ND) does contribute to improvement in survival and should be performed for patients with high-risk tongue cancer. At present, no research has clearly demonstrated the utility of superselective arterial infusion chemotherapy. However, depending on the site and stage of the cancer, combination with radiotherapy may be useful for preserving organ function or improving survival rate. Concurrent CDDP chemotherapy and adjuvant radiotherapy contributes to improvement of survival rate as an adjuvant therapy for advanced squamous cell carcinoma of the head and neck in patients at high risk of recurrence. The anti-EGFR antibody cetuximab (Cmab) has an additive effect with radiotherapy. However, the indication must be carefully considered since this treatment has not been compared with the standard treatment of chemoradiotherapy. Cmab has been shown to have an additive effect with chemotherapy (CDDP/5-FU) in patients with unresectable metastatic or recurrent cancer. Preoperative and postoperative oral care may reduce the risk of postoperative complications such as surgical wound infection and pneumonia in head and neck cancers. Rehabilitation soon after ND for cervical lymph node metastasis is recommended for maintaining and restoring shoulder function. CONCLUSIONS: In this article, we described most relevant guidelines and CQs for the diagnosis and treatment of head and neck cancer in Japan. These guidelines are not intended to govern therapies that are not shown here, but rather aim to be used as a guide in searching for the most appropriate treatment for individual patient.
    Aug. 2017, Auris, nasus, larynx, 44(4) (4), 375 - 380, English, International magazine
    [Refereed]
    Scientific journal

  • 高齢がん患者におけるサルコペニア、認知機能低下、社会的孤立の術前有症率と術後合併症への影響
    小野 玲, 福田 章真, 牧浦 大祐, 斎藤 貴, 奥村 真帆, 井上 順一朗, 中村 哲, 山本 将士, 丹生 健一, 掛地 吉弘, 酒井 良忠
    (NPO)日本緩和医療学会, Jun. 2017, Palliative Care Research, 12(Suppl.) (Suppl.), S349 - S349, Japanese
    [Refereed]

  • Mehmet Özgür Avinçsal, Yurie Hiroshima, Hitomi Shinomiya, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu
    OBJECTIVE: First bite syndrome is the development of pain in the ipsilateral parotid region after the first few bites of food and can be seen after surgery of the upper cervical region. The aim of this study is to highlight the etiology of this potentially debilitating chronic pain syndrome. MATERIALS AND METHODS: Retrospective review of 53 patients undergoing surgery of the upper neck between 2002 and 2013. RESULTS: FBS developed in 16 patients (30%). Partial resolution of FBS symptoms occurred in 69% and complete resolution in 12%, whereas 15% had no change. FBS was most common in the patients who had tumor arising from deep lobe of parotid gland in comparison with other sites (50% vs 18%, p=0.017). FBS developed in 57% of patients undergoing external carotid artery (ECA) ligation and in 12.5% of patients in whom ECA was preserved (p=0.0008). Among the patients in whom ECA was preserved, FBS developed in 43% of the patients in whom sympathetic chain was sacrificed and in 4% of the patients in whom sympathetic chain was preserved. CONCLUSION: Present results further support the role of sympathetic chain in the development of FBS.
    Jun. 2017, Auris, nasus, larynx, 44(3) (3), 302 - 305, English, International magazine
    [Refereed]

  • Mehmet Ozgur Avincsal, Yurie Hiroshima, Hitomi Shinomiya, Hirotaka Shinomiya, Naoki Otsuki, Ken-ichi Nibu
    Jun. 2017, AURIS NASUS LARYNX, 44(3) (3), 302 - 305, English
    [Refereed]
    Scientific journal

  • 頸動脈小体腫瘍における術前栄養動脈塞栓術の有用性について
    池田 文, 及川 伸一, 齋藤 大輔, 片桐 克則, 志賀 清人, 金子 賢一, 大月 直樹, 丹生 健一, 小澤 宏之, 藤本 保志
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 211 - 211, Japanese

  • 個別化治療を目指した頭頸部癌診療ガイドライン
    本間 明宏, 丹生 健一, 中溝 宗永, 水町 貴諭, 林 隆一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 143 - 143, Japanese

  • Taizo Takeda, Setsuko Takeda, Natsumi Uehara, Shungaku Yanagisawa, Tatsuya Furukawa, Ken-Ichi Nibu, Akinobu Kakigi
    OBJECTIVE: The correlation between the isosorbide-induced decompression effect on the endolymphatic space and plasma osmolality (p-OSM) or plasma arginine vasopressin (p-AVP) was investigated on comparing two different dosages of isosorbide (2.8 and 1.4 g/kg) to elucidate why the decompression effect is delayed with a large dose of isosorbide. MATERIALS AND METHODS: Two experiments were performed using 80 guinea pigs. Experiment 1 was designed to morphologically investigate the sequential influence of the oral intake of 1.4- and 2.8-g/kg doses of isosorbide on the endolymphatic volume. The animals used were 50 guinea pigs (control: 10, experimental: 40). All animals underwent surgical obliteration of the endolymphatic sac of the left ear. One month after the surgery, control animals were sacrificed 3 hours after the intake of distilled water, and experimental animals were sacrificed 3 and 6 hours after the isosorbide intake. All of the left temporal bone served for the quantitative assessment of changes in the endolymphatic space, and the cross-sectional area of the scala media was measured from the mid-modiolar sections of the cochlea.Experiment 2 was designed to investigate changes in p-OSM and p-AVP levels 3 hours after the oral intake of isosorbide. Animals used were 15 guinea pigs (control: 5, experimental: 10). The control group received the oral administration of distilled water (4 ml/kg), and the experimental animals were subdivided into two groups consisting of 10 animals each by the dosage of isosorbide (1.4 or 2.8 g/kg). All animals were sacrificed for the measurement of p-OSM and p-AVP concentrations 3 hours after the intake of water or 70% isosorbide solution. RESULTS: Morphologically, an isosorbide-induced decompression effect was noted in animals with both 1.4- and 2.8-g/kg doses of isosorbide. According to the regression analysis, however, the volumetric decrease of the endolymphatic space was more evident in cases with the small dose (1.4 g/kg) 3 hours after the intake (analysis of covariance [ANCOVA], p < 0.001). Six hours after, the decompression effect was significantly greater in cases with the large dose (2.8 g/kg) (ANCOVA, p < 0.001).Isosorbide intake caused a rise in p-OSM levels dose-dependently. The Cochran-Cox test revealed that the differences in the mean values among control and isosorbide groups were significant (p < 0.01). Regarding the p-AVP level, a significant increase was evident in cases with the large dose (2.8 g/kg) (p < 0.01, Cochran-Cox test), and not in cases with the small dose (1.4 g/kg). CONCLUSION: An isosorbide-induced decompression effect of the endolymphatic space was evident in spite of two different dosages of isosorbide (2.8 and 1.4 g/kg). Three hours after the isosorbide intake, however, the decompression effect was more marked in the group with the small dose (1.4 g/kg). Since significant rises in p-OSM and p-AVP were evident in the group with the large dose, this early rise of p-AVP due to dehydration seems to be the major reason for the delayed decompression effect in cases with a large isosorbide intake.
    Apr. 2017, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 38(4) (4), 599 - 605, English, International magazine
    [Refereed]
    Scientific journal

  • Yusuke Takahashi, Tsutomu Minamikawa, Natsuki Yonezawa, Hirokazu Komatsu, Kenichi Nibu, Takahide Komori
    Elsevier Ltd, Mar. 2017, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(2) (2), 105 - 109, English
    [Refereed]
    Scientific journal

  • Shinobu Iwaki, Tatsuyoshi Maeda, Miki Saito, Naoki Otsuki, Miki Takahashi, Emi Wakui, Hirotaka Shinomiya, Koichi Morimoto, Hiroyuki Inoue, Hiroo Masuoka, Akira Miyauchi, Ken-Ichi Nibu
    Mar. 2017, Head & neck, 39(3) (3), 427 - 431, English, International magazine
    [Refereed]
    Scientific journal

  • Takeaki Ishihara, Kazuhiro Kitajima, Yuko Suenaga, Yasuo Ejima, Hirokazu Komatsu, Naoki Otsuki, Ken-Ichi Nibu, Naomi Kiyota, Satoru Takahashi, Ryohei Sasaki
    This study evaluated the prognostic significance of the maximum standardized uptake value of the primary site (pSUVmax) in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of patients with oropharyngeal or hypopharyngeal cancer who were treated using definitive radiotherapy. The study included 86 patients who were primarily treated with radiotherapy for oropharyngeal or hypopharyngeal cancer. Sixty-nine patients underwent concurrent chemotherapy. The associations between pre-treatment pSUVmax and treatment outcomes were evaluated. The most appropriate pSUVmax cut-off value for predicting disease-free survival (DFS) and local control (LC) was selected using receiver operating characteristic (ROC) curves. The median follow-up time for surviving patients was 60 months, while the median survival time in the entire patient cohort was 55 months. A pSUVmax cut-off value of 9.0 showed the best discriminative performance. Five-year OS and DFS rates were 65.9% and 60.0%, respectively. In univariate analyses, pSUVmax (p = 0.009), T-stage (p = 0.001), N-stage (p = 0.039), and clinical stage (p = 0.017) were identified as significant prognostic predictors for DFS. The multivariate analysis did not identify any statistically significant factors, but the association between pSUVmax and DFS was borderline significant (p = 0.055). Interestingly, pSUVmax was predictive of local controllability in T1-T2 disease (p = 0.024), but there was no significant association for T3-T4 disease (p = 0.735). In this study, pSUVmax was predictive of DFS and LC in patients with oropharyngeal or hypopharyngeal cancer that was treated with definitive radiotherapy. pSUVmax was strongly associated with LC in T1-T2 disease.
    Feb. 2017, Nagoya journal of medical science, 79(1) (1), 27 - 36, English, Domestic magazine
    [Refereed]

  • Natsuki Yonezawa, Tsutomu Minamikawa, Kazuhiro Kitajima, Yusuke Takahashi, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    The aim of this study was to investigate the prognostic value of dual-time-point (DTP) 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging in primary oral tongue squamous cell carcinoma (OTSCC). The study included 52 patients who underwent preoperative 18F-FDG PET scans at two time points, namely 1 h and 2 h after injection. The following PET parameters were calculated: maximum standardized uptake value (SUVmax) for both time points (SUV early, SUV delayed); retention index (RI); and SUVmax increment (ΔSUVmax). Receiver operating characteristic (ROC) curve analysis was performed to define the optimal cutoff point for these parameters. Overall survival was calculated using the Kaplan-Meier method. Prognostic factors for patients with OTSCC were evaluated using the univariate log-rank test and a multivariate Cox proportional hazards model. ROC analysis revealed that the area under the curve was higher and more accurate for ΔSUVmax than for the other parameters. Additionally, patients with a ΔSUVmax ≥0.9 had significantly worse survival outcomes (28.9% vs 92.6%; p < 0.01). Univariate analysis showed that prognosis was significantly correlated with clinical T stage, local recurrence, perineural invasion, vascular invasion, and PET parameters (p < 0.05 for all). Multivariate analysis showed that local recurrence (hazard ratio = 3.60; p = 0.02) and ΔSUVmax (hazard ratio = 8.43; p < 0.01) were independent prognostic factors. ΔSUVmax determined using DTP 18F-FDG PET may be an additional prognostic factor in OTSCC patients.
    Feb. 2017, Nagoya journal of medical science, 79(2) (2), 189 - 198, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Hitomi Shinomiya, Daisuke Yamashita, Takeshi Fujita, Eiji Nakano, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Chikako Nishigori, Ken-Ichi Nibu
    Xeroderma pigmentosum (XP) is a rare recessive heredity disease caused by DNA repair impairment characterized by photosensitivity and neurologic symptoms in half of the cases. There are eight subtypes of XP: XP-A-XP-G and XP variant. Among eight subtypes, XP complementation group A (XP-A) display the lowest DNA repair ability and the severest cutaneous and neurologic symptoms. While its pathogenesis of skin symptoms have been well-studied, that of neurological symptoms, including sensorineural hearing loss (SNHL) remains unknown. Basic studies have suggested that SNHL may be caused by inner ear damage, including damage to the spiral ganglion neurons and organ of Corti, and that the XP-A is associated with most severe form of SNHL in humans. Here, we report the occurrence of SNHL in Xpa-deficient mice. Xpa-deficient mice and wild-type mice underwent measurements for auditory brainstem response, and the results revealed that Xpa-deficient mice exhibited significantly greater (p < 0.01) ABR thresholds at 4, 8, and 16 kHz than the wild-type mice. Furthermore, the number of spiral ganglion neurons was reduced in Xpa-deficient mice compared with that in wild-type mice, indicating that hearing loss may be related to spiral ganglion neuron deficiency, consistent with the few reports published in human patients with XP. These results provide important insights into the pathogenesis of SNHL in patients with XP-A.
    2017, Frontiers in aging neuroscience, 9, 19 - 19, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shinobu Iwaki, Emi Wakui, Miki Takahashi, Hirotaka Shinomiya, Koichi Morimoto, Miki Saito, Ken-Ichi Nibu
    Japan Society of Logopedics and Phoniatrics, 2017, Japan Journal of Logopedics and Phoniatrics, 58(2) (2), 152 - 158, Japanese
    Scientific journal

  • Hirotaka Shinomiya, Hitomi Shinomiya, Mie Kubo, Yuki Saito, Masafumi Yoshida, Mizuo Ando, Masanori Teshima, Naoki Otsuki, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu
    2017, PloS one, 12(12) (12), e0187992, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 当院における再発転移頭頸部扁平上皮癌に対する初回化学療法としてのセツキシマブ併用療法の遡及的検討
    今村善宣, 清田尚臣, 大月直樹, 森本浩一, 四宮弘隆, 江島泰生, 南川勉, Sasaki Ryohei, 丹生健一
    (一社)日本頭頸部癌学会, Dec. 2016, 頭頸部癌, 42(4) (4), 432 - 437, Japanese
    [Refereed]
    Scientific journal

  • Tomoko Kataoka, Naomi Kiyota, Takanobu Shimada, Yohei Funakoshi, Naoko Chayahara, Masanori Toyoda, Yutaka Fujiwara, Ken-Ichi Nibu, Takahide Komori, Ryohei Sasaki, Toru Mukohara, Hironobu Minami
    OBJECTIVE: Radiation-induced mucositis (RIM) in chemoradiotherapy (CRT) for head and neck cancer (HNC) causes severe pain and worsens CRT compliance, QOL and outcome. Following retrospective reports, we conducted a randomized trial of the safety and efficacy of gabapentin for RIM-associated pain during CRT. METHODS: HNC patients (pts) receiving CRT were randomized to standard pain control (SPC) with acetaminophen and opioids, or SPC plus gabapentin (SPC+G). Gabapentin was maintained at 900mg/day for 4 weeks after CRT. Primary endpoint was maximum visual analogue scale (VAS) score during CRT, and secondary endpoints were total opioid dose, changes in QOL (EORTC QLQ-C30 and QLQ-HN 35) from baseline to 4 weeks after CRT, and adverse events. RESULTS: Twenty-two eligible Stage III or IV pts were randomly assigned to SPC or SPC+G (n=11 each). Twelve were treated in a locally advanced setting and 10 in a postoperative setting. Median maximum VAS scores, median total dose of opioids at maximum VAS and total dose of opioids at 4 weeks after CRT tended to be higher in the SPC+G arm (47 in SPC vs. 74 in SPC+G, p=0.517; 215mg vs. 745.3mg, p=0.880; and 1260mg vs. 1537.5mg, p=0.9438, respectively), without significance. QOL analysis showed significantly worse scores in the SPC+G arm for weight gain (p=0.005). Adverse events related to gabapentin were manageable. CONCLUSIONS: This pilot study is the first prospective randomized trial of gabapentin for RIM-related pain. Gabapentin had no apparent beneficial effect. Further research into agents for RIM-related pain is warranted.
    Dec. 2016, Auris, nasus, larynx, 43(6) (6), 677 - 84, English, International magazine
    [Refereed]
    Scientific journal

  • Hikari Shimoda, Koichiro Yonezawa, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Ryohei Sasaki, Eiji Komura, Ken-Ichi Nibu
    BACKGROUND: Extirpation of tumors arising in the pterygopalatine fossa is challenging because of its anatomic complexity. METHODS AND RESULTS: A 67-year-old man was referred to our department with a diagnosis of a tumor in his left pterygoid fossa. An incisional biopsy through the canine fossa was diagnosed as myxofibrosarcoma. The upper part of the maxilla was swung laterally to remove the tumor while the hard plate was preserved. The defect was reconstructed using rectus abdominis musculocutaneous free and ipsilateral temporal. The postoperative course was uneventful, without facial palsy or mastication disorders. CONCLUSION: Our experience with this case suggests that the modified partial maxillary swing approach with preservation of the hard palate and orbital floor in combination with infratemporal and cervical approaches is useful for lesions in the pterygoid process without causing severe complications. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2519-E2522, 2016.
    Dec. 2016, Head & neck, 38(12) (12), E2519-E2522 - E2522, English, International magazine
    [Refereed]
    Scientific journal

  • Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    PURPOSE: This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. METHODS: A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of ORN, relationship between tooth extraction and ORN occurrence, and time interval between tooth extraction and the initiation or end of RT. RESULTS: Twenty-one percent of ORN cases resulted from tooth extraction. The most common site of ORN (82 %) was the mandibular molar region. About half of ORN cases (49 %) occurred within 2 years after RT. All patients who received tooth extraction after RT developed ORN (100 %) independently of time interval between tooth extraction and the end of RT (median interval, 37.5 months; range, 27-120 months). In contrast, only 50 % of patients who received tooth extraction before RT developed ORN. There may have been an association between the irradiation field and the site of ORN development CONCLUSIONS: ORN occurrence due to tooth extraction was 21 %. Occurrence timing of ORN did not depend on time interval between tooth extraction and the end of RT. The irradiation field is certainly related to the site of ORN; therefore, prophylactic tooth extraction should be performed in consideration of the proposed radiation field and dose.
    Dec. 2016, Oral and maxillofacial surgery, 20(4) (4), 337 - 342, English, International magazine
    [Refereed]
    Scientific journal

  • Hitomi Shinomiya, Yohei Ito, Mie Kubo, Koichiro Yonezawa, Naoki Otsuki, Shigemichi Iwae, Hiroshi Inagaki, Ken-Ichi Nibu
    In mucoepidermoid carcinoma (MEC), CRTC1-MAML2 fusion indicates a favorable prognosis. Amphiregulin (AREG), an epidermal growth factor receptor (EGFR) ligand, has been shown to be a downstream target of CRTC1-MAML2 fusion, and to play a role in tumor growth and survival in CRTC1-MAML2-positive MEC cell lines. The aim of this study was to characterize the AREG and EGFR expression in the fusion-positive and fusion-negative MEC of the major salivary gland. The AREG and EGFR expression were studied by immunochemistry in 33 MEC cases of the major salivary glands. CRTC1-MAML2 fusion was tested by reverse-transcription polymerase chain reaction (23 CRTC1-MAML2 fusion-positive, 10 fusion-negative). Of 23 fusion-positive cases, AREG and EGFR overexpression were detected in 17 (73.9%) and 14 (60.9%) cases, respectively. Of 10 fusion-negative cases, AREG and EGFR overexpression were detected in 1 (10%) and 3 (30.0%) cases, respectively. There was a positive correlation between CRTC1-MAML2 fusion and AREG overexpression (P < .01), but not between CRTC1-MAML2 fusion and EGFR overexpression. The AREG overexpression was associated with a longer disease-free survival of the MEC patients (P = .042), but EGFR overexpression was not. In this study, we showed that AREG overexpression was detected more frequently in the CRTC1-MAML2 fusion-positive tumors than in fusion-negative tumors. Detection of AREG expression may be useful for identifying CRTC1-MAML2-positive MECs and as a marker for favorable prognosis.
    Nov. 2016, Human pathology, 57, 37 - 44, English, International magazine
    [Refereed]
    Scientific journal

  • Akihiro Homma, Ryuichi Hayashi, Kazuyoshi Kawabata, Takashi Fujii, Shigemichi Iwae, Yasuhisa Hasegawa, Kenichi Nibu, Takakuni Kato, Kiyoto Shiga, Kazuto Matsuura, Nobuya Monden, Masato Fujii
    Oct. 2016, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(10) (10), 1495 - 1500, English
    [Refereed]
    Scientific journal

  • Hitomi Shinomiya, Naoki Otsuki, Daisuke Yamashita, Ken-Ichi Nibu
    OBJECTIVE: To define the incidence and pattern of spread of lymph node metastasis from parotid cancers and to clarify the risk factors and appropriate extent of neck dissection (ND) for individual patient with parotid cancer. METHODS: A total of 72 patients with parotid gland cancer treated by surgery between 1994 and 2013 were analyzed retrospectively by reference to medical records. In line with our protocol, patients with clinically positive lymph nodes and/or cT3/T4 disease were generally selected to undergo ND. RESULTS: Pathological examinations revealed mucoepidermoid carcinoma in 23 patients, carcinoma ex pleomorphic adenoma in 11, adenoid cystic carcinoma in 9, salivary duct carcinoma in 9, acinic cell carcinoma in 8, squamous cell carcinoma in 5, adenocarcinoma NOS in 4, epithelial myoepithelial carcinoma in 2, and basal cell carcinoma in 1. Thirty-three patients underwent neck dissection: modified radical ND (MRND) in 13, and elective ND (END) in 20. Postoperative RT (PORT) was performed in 33 patients. Among 13 cN+ patients, 10 were pN+ and lymph node metastasis was distributed mainly in levels I, II, III and V. Among 59 cN- patients, clinical T1, T2, T3 and T4 classifications accounted for 10, 24, 10 and 15 patients, respectively. The incidence of occult lymph node metastasis was 22%. Occult lymph node metastasis was mostly seen in the intraparotid, levels I and II of patients with cT4 disease. Among the ND group, 12 necks were pathologically negative for cancer (pN0). Relapse of neck lymph node metastasis occurred only in two patients treated by MRND with pathologically positive lymph nodes (pN+). These patients developed local and distant metastasis within 1 year after neck lymph node recurrence, and subsequently died of the cancer. pN+ was found in 19/30 high grade (63%), 1/10 intermediate grade (10%), and 3/32 low grade (9.4%). Among 33 patients who received PORT, only 1 patient relapsed neck lymph node. CONCLUSION: For patients with clinically positive lymph nodes, ipsilateral modified radical neck dissection (levels I-V) is recommended. Elective neck dissection is strongly recommended for patients with T3N0 or T4N0 disease, and the extent of ND should include at least level I/II. PORT for patients with high-risk features may improve the outcome of good neck control.
    Aug. 2016, Auris, nasus, larynx, 43(4) (4), 446 - 50, English, International magazine
    [Refereed]
    Scientific journal

  • 進行がんにおけるリハビリテーションとチーム医療 進行がん患者のコミュニケーションと嚥下機能を支えるには
    高橋 美貴, 涌井 絵美, 三浦 靖史, 酒井 良忠, 丹生 健一
    (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), S269 - S269, Japanese

  • 勝沼 紗矢香, 富樫 英, 丹生 健一
    耳鼻咽喉科ニューロサイエンス研究会, May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 53 - 54, Japanese

  • 再発・転移頭頸部扁平上皮癌に対するPCE併用療法の第II相試験(CSPOR-HN02)
    福田 裕次郎, 長谷川 泰久, 鬼塚 哲郎, 丹生 健一, 川端 一嘉, 岩江 信法, 本間 明宏, 鈴木 政美, 家根 且有, 山中 竹春, 田原 信
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 194 - 194, Japanese

  • 鼻腔腫瘍に対する放射線治療の経験
    西川遼, 吉田賢史, Miyawaki Daisuke, 石原武明, 井上由子, 松尾圭朗, ノル・シャズリナ, 江島泰生, 大月直樹, 丹生健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2号) (2号), 207 - 207, Japanese
    [Refereed]
    Research society

  • 同時併用化学放射線療法を施行した進行期喉頭癌、下咽頭癌症例におけるTalk Scoreの検討
    高橋美貴, 松井美緒, 涌井絵美, 清田尚臣, Sasaki Ryohei, 大月直樹, 宇佐美眞, 丹生健一
    May 2016, 頭頸部癌, 42(2号) (2号), 181, Japanese
    Research society

  • 当科で放射線治療を施行した下咽頭癌T1・T2症例の検討
    古川竜也, 大月直樹, 四宮弘隆, 小松弘和, 森本浩一, 清田尚臣, Sasaki Ryohei, 丹生健一
    May 2016, 頭頸部癌, 42(2号) (2号), 181, Japanese
    Research society

  • 舌癌術後再発症例に対する放射線治療成績
    Miyawaki Daisuke, 江島泰生, 吉田賢史, 石原武明, 西川遼, 清田尚臣, 南川勉, 大月直樹, 丹生健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2号) (2号), 207 - 207, Japanese
    [Refereed]
    Research society

  • セツキシマブ追加の有無による、再発性/転移性頭頸部癌の第一選択治療の比較(First-line Treatment of Recurrent/Metastatic Head and Neck Cancer with or without Cetuximab)
    今村 善宣, 清田 尚臣, 大月 直樹, 森本 浩一, 四宮 弘隆, 江島 泰生, 吉田 賢史, 南川 勉, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 211 - 211, English
    Research society

  • Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明
    井之口豪, 薛富義, 吉川知志, 寺島俊雄, 四宮瞳, 藤田岳, 山下大介, Nibu Ken-ichi
    May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 20 - 22, Japanese
    [Refereed]
    Scientific journal

  • 小山 泰司, 丹生 健一
    (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2016, 日本耳鼻咽喉科学会会報, 119(4) (4), 684 - 684, Japanese

  • Hirotaka Shinomiya, Shingo Hasegawa, Daisuke Yamashita, Yasuo Ejima, Yoshida Kenji, Naoki Otsuki, Naomi Kiyota, Shunsuke Sakakibara, Tadashi Nomura, Kazunobu Hashikawa, Eiji Kohmura, Ryohei Sasaki, Ken-ichi Nibu
    Apr. 2016, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38, E949 - E953, English
    [Refereed]
    Scientific journal

  • Yuko Suenaga, Kazuhiro Kitajima, Takeaki Ishihara, Ryohei Sasaki, Naoki Otsuki, Ken-ichi Nibu, Tsutomu Minamikawa, Naomi Kiyota, Kazuro Sugimura
    Apr. 2016, EUROPEAN RADIOLOGY, 26(4) (4), 1018 - 1030, English
    [Refereed]
    Scientific journal


  • 【どこが変わった頭頸部癌診療ガイドライン】 ここが変わった頭頸部癌診療ガイドライン
    Nibu Ken-ichi
    (株)医学書院, Sep. 2018, 耳鼻咽喉科・頭頸部外科, 90(10) (10), 798 - 799, Japanese
    [Refereed]

  • 高齢者に対するがん治療
    Nibu Ken-ichi
    Jul. 2018, 日本耳鼻咽喉科学会会報, 121(7号) (7号), 882 - 886, Japanese
    [Invited]
    Introduction scientific journal

  • 椿の枝で受傷した外傷性外リンパ瘻の1例
    上原 奈津美, 柿木 章伸, 丹生 健一
    耳鼻咽喉科臨床学会, Jun. 2018, 耳鼻咽喉科臨床 補冊, (補冊153) (補冊153), 70 - 70, Japanese

  • 【わかりやすい感覚器疾患】 感覚器と感覚器疾患のトピックス 再生医療 嗅覚・味覚
    藤尾久美, Nibu Ken-ichi
    (公社)日本医師会, Jun. 2018, 日本医師会雑誌, 147(特別1) (特別1), S318 - S318, Japanese
    [Refereed]

  • 口腔癌cN1症例に関する頸部郭清術の郭清範囲についての検討
    筧康正, 南川勉, 小松弘和, 大月直樹, 丹生健一, 古森孝英
    (一社)日本頭頸部癌学会, 09 May 2018, 頭頸部癌, 44(2) (2), 140 - 140, Japanese

  • 再発・転移の頭頸部非扁平上皮癌に対するドセタキセル+シスプラチン併用療法の第II相臨床試録
    今村善宣, 清田尚臣, 田中薫, 林秀俊, 太田一郎, 平野滋, 岩江信法, 南修司郎, 家根且有, 山崎知子, 長谷善明, 豊田昌徳, 大月直樹, 丹生健一, 南博信
    (一社)日本頭頸部癌学会, 09 May 2018, 頭頸部癌, 44(2) (2), 126 - 126, Japanese

  • 聴器原発悪性腫瘍の予後因子に関する検討
    四宮 弘隆, 手島 直則, 大月 直樹, 柿木 章伸, 丹生 健一
    (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 180 - 180, Japanese

  • 甲状腺癌気道浸潤例に対する放射線外照射の有効性の検討
    鈴木 千晶, 清田 尚臣, 大月 直樹, 宮脇 大輔, 今村 善宣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2018, 頭頸部癌, 44(2) (2), 176 - 176, Japanese

  • AMED研究:頭頸部癌領域 頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 379 - 379, Japanese

  • オープンエッセンス法による感冒後嗅覚障害の検討
    黒木 俊介, 藤尾 久美, 蓼原 瞬, 井之口 豪, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 534 - 534, Japanese

  • 口腔底癌心臓転移の一例
    藤尾 久美, 大月 直樹, 堀地 祐人, 手島 直則, 四宮 弘隆, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 608 - 608, Japanese

  • 頭頸部腺様嚢胞癌63例の臨床病理学的検討
    池田 千浦子, 森田 成彦, 大月 直樹, 西尾 真理, 狛 雄一朗, 丹生 健一, 伊藤 智雄, 横崎 宏
    (一社)日本病理学会, Apr. 2018, 日本病理学会会誌, 107(1) (1), 460 - 460, Japanese

  • 【ガイドライン改訂にみるがん診療の変遷】 臓器別がん診療・治療ガイドライン 頭頸部がん診療ガイドライン
    Nibu Ken-ichi
    Apr. 2018, 腫瘍内科, 21(4号) (4号), 454 - 458, Japanese
    Introduction scientific journal

  • 唾液腺原発腺様嚢胞癌におけるEGFR蛋白高発現とその臨床病理学的意義
    村瀬貴幸, 齋田昂佑, 川北大介, 草深公秀, 長尾徹, 花井信広, 丹生健一, 稲垣宏
    2018, 頭頸部癌, 44(2) (2)

  • Hanazawa Toyoyuki, Nibu Kenichi, Asakage Takahiro, Kobayashi Masayoshi, Nakagawa Takayuki, Otori Nobuyoshi, Fujimoto Yasushi, Kodama Satoru, Sanuki Tetsuji, Tanaka Shuho, Ariizumi Yosuke
    The Oto-Rhino-Laryngological Society of Japan, Inc., 2018, Nippon Jibiinkoka Gakkai Kaiho, 121(2) (2), 119 - 126, Japanese

  • 進行期唾液腺原発粘表皮癌に対する初回外科的切除後治療 CRTC1/3-MAML2キメラ遺伝子の意義
    奥村 嘉英, 村瀬 貴幸, 齋田 昂佑, 藤井 香那, 丹生 健一, 多田 雄一郎, 稲垣 宏
    日本唾液腺学会, Nov. 2017, 日本唾液腺学会誌, 58, 29 - 29, Japanese

  • 唾液腺腺様嚢胞癌 EGFR経路における遺伝子異常解析
    齋田 昂佑, 村瀬 貴幸, 藤井 香那, 川北 大介, 草深 公秀, 長谷川 泰久, 丹生 健一, 多田 雄一郎, 稲垣 宏
    日本唾液腺学会, Nov. 2017, 日本唾液腺学会誌, 58, 31 - 31, Japanese

  • 唾液腺原発粘表皮癌におけるEGFR経路遺伝子変異の臨床病理学的意義
    伊藤 万優子, 齋田 昂佑, 藤井 香那, 奥村 嘉英, 村瀬 貴幸, 丹生 健一, 多田 雄一郎, 稲垣 宏
    日本唾液腺学会, Nov. 2017, 日本唾液腺学会誌, 58, 32 - 32, Japanese

  • 先天性真珠腫術後の再形成性真珠腫により外耳道後壁が広汎に破壊された1例
    横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 423 - 423, Japanese

  • 難聴を契機に診断されたCat Eye症候群の1例
    上原 奈津美, 長谷川 信吾, 柿木 章伸, 丹生 健一
    (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 665 - 665, Japanese

  • OTSUKI NAOKI, NIBU KENICHI
    (株)東京医学社, Sep. 2017, JOHNS, 33(9) (9), 1282 - 1285, Japanese
    Introduction commerce magazine

  • FURUKAWA TATSUYA, NIBU KENICHI
    (株)医学書院, Jul. 2017, 耳鼻咽喉科・頭頸部外科, 89(8) (8), 609 - 615, Japanese
    Introduction commerce magazine

  • Bulletin 第5回 アジア頭頸部癌学会(ASHNO 2017)
    丹生 健一
    メディカルレビュー社, Jun. 2017, 頭頸部癌frontier, 5(1) (1), 56 - 58, Japanese

  • NIBU KENICHI, OTSUKI NAOKI, SHINOMIYA HIROTAKA, SHINOMIYA HITOMI, UEHARA NATSUMI
    耳鼻咽喉科臨床学会, Jun. 2017, 耳鼻咽喉科臨床, 110(6) (6), 367 - 374, Japanese
    Introduction scientific journal

  • OTSUKI NAOKI, NIBU KENICHI
    日本内分泌外科学会・日本甲状腺外科学会, Jun. 2017, 日本内分泌・甲状腺外科学会雑誌, 34(2) (2), 113 - 117, Japanese
    Introduction scientific journal

  • 局所進行頭頸部扁平上皮癌に対するTPE導入化学療法と放射線治療及びセツキシマブ併用療法の第II相試験
    岡野 晋, 岩江 信法, 丹生 健一, 川端 一嘉, 北村 守正, 藤井 正人, 上田 勉, 門田 伸也, 全田 貞幹, 田原 信
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 202 - 202, Japanese

  • 当科における聴器原発悪性腫瘍T1、T2例37例の臨床的検討
    四宮 弘隆, 柿木 章伸, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 206 - 206, Japanese

  • 唾液腺原発粘表皮癌初回外科的切除後の放射線治療適応 CRTC1/3-MAML2融合遺伝子陽性T1/2N0M0症例の検討
    奥村 嘉英, 村瀬 貴幸, 齋田 昂佑, 藤井 香那, 伊地知 圭, 下郷 和雄, 多田 雄一郎, 丹生 健一, 村上 信五, 稲垣 宏
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 190 - 190, Japanese

  • 個別化治療を目指した頭頸部癌診療ガイドライン 頭頸部がんに対する放射線治療の個別化 治療効果予測からの検討
    佐々木 良平, 宮脇 大輔, 清田 尚臣, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 144 - 144, Japanese

  • 局所進行頭頸部扁平上皮癌における導入化学療法TPFの安全性と有効性の検討
    長谷 善明, 清田 尚臣, 今村 善宜, 宮脇 大輔, 佐々木 良平, 四宮 弘隆, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 177 - 177, Japanese

  • 当院における嗅神経芽細胞腫症例の検討
    古川 竜也, 大月 直樹, 四宮 弘隆, 森田 成彦, 井之口 豪, 古閑 紀雄, 清田 尚臣, 佐々木 良平, 甲村 英二, 丹生 健一
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 205 - 205, Japanese

  • 個別化治療を目指した頭頸部癌診療ガイドライン 喉頭・下咽頭癌における喉頭温存治療法のガイドラインへの反映
    藤井 博文, 林 隆一, 丹生 健一, 中溝 宗永, 古平 毅, 西野 宏, 齋藤 祐毅
    (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 145 - 145, Japanese

  • 【内視鏡手術の上達ポイント】《咽喉頭・唾液腺領域》 経口的咽喉頭部分切除術
    MORIMOTO KOICHI, NIBU KENICHI
    Apr. 2017, 耳鼻咽喉科・頭頸部外科, 89(4) (4), 333 - 339, Japanese
    Introduction commerce magazine

  • 鼻腔腫瘍に対する放射線治療の経験
    清家 翔平, 吉田 賢史, 宮脇 大輔, 石原 武明, 井上 由子, 松尾 圭朗, 西川 遼, ノル・シャズリナ, 江島 泰生, 佐々木 良平, 斎藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 41 - 41, Japanese

  • 当院におけるT3N0M0喉頭癌の放射線治療成績
    石原 武明, 松尾 圭朗, 西川 遼, 宮脇 大輔, 吉田 賢史, 江島 泰生, 佐々木 良平, 清田 尚臣, 森本 浩一, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2017, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 46 - 46, Japanese

  • Alvaro Sanabria, Aline L F Chaves, Luiz P Kowalski, Gregory T Wolf, Nabil F Saba, Arlene A Forastiere, Jonathan J Beitler, Ken-Ichi Nibu, Carol R Bradford, Carlos Suárez, Juan P Rodrigo, Primož Strojan, Alessandra Rinaldo, Remco de Bree, Missak Haigentz Jr, Robert P Takes, Alfio Ferlito
    BACKGROUND: The primary goal of treatment in advanced laryngeal cancer is to achieve optimal oncologic outcomes while preserving function and quality of life. Combination of chemotherapy and radiation has been popularized as an alternative to surgery for patients facing total laryngectomy. However, survival analyses from large, population-based databases have not duplicated results reported from randomized trials. METHODS: A comprehensive literature review was undertaken to try to better understand the reasons why results differ among randomized trials and population cohort studies. RESULTS: A variety of reasons are discussed, including differences in patient staging, selection bias, complexity bias, inconsistent terminology, patient compliance and treatment expertise. CONCLUSIONS: Personalized treatment considering all factors is critical for optimal outcomes. In general, evidence supports total laryngectomy for patients with T4 cancers. Definitive chemoradiotherapy strategies are acceptable alternatives for T3 cancers, provided that all resources for the administration of the treatment, follow-up and surgical salvage are available.
    Feb. 2017, Auris, nasus, larynx, 44(1) (1), 18 - 25, English, International magazine
    [Refereed]

  • Hitomi Shinomiya, Naoki Otsuki, Daisuke Yamashita, Ken-Ichi Nibu
    Oto-Rhino-Laryngological Society of Japan Inc., 2017, Journal of Otolaryngology of Japan, 120(2) (2), 152 - 153, Japanese
    Book review

  • Ken-Ichi Nibu, Naoki Otsuki, Hirotaka Shinomiya, Hitomi Shinomiya, Natsumi Uehara
    Society of Practical Otolaryngology, 2017, Practica Oto-Rhino-Laryngologica, 110(6) (6), 367 - 374, Japanese
    [Refereed]
    Book review

  • 【嗅覚-New horizon】 神経疾患と治療 変性疾患を疑うべき嗅覚障害
    藤尾久美, Nibu Ken-ichi
    Dec. 2016, Clinical Neuroscience, 34(12号) (12号), 1357 - 1359, Japanese
    [Invited]
    Introduction commerce magazine

  • Synergistic action of nectins and cadherins establish the mosaic cellular pattern of the olfactory epithelium
    Sayaka Katsunuma, Hisao Honda, Ken-ichi Nibu, Hideru Togashi
    Nov. 2016, CHEMICAL SENSES, 41(9) (9), E155 - E156, English
    Summary international conference

  • CRTC1/3-MAML2キメラ遺伝子陽性唾液腺原発粘表皮癌患者(T1/2N0M0)における、初回外科的切除後の放射線治療適応の検討
    奥村 嘉英, 村瀬 貴幸, 斎田 昂佑, 丹生 健一, 多田 雄一郎, 伊地知 圭, 稲垣 宏
    日本唾液腺学会, Nov. 2016, 日本唾液腺学会誌, 57, 29 - 29, Japanese

  • Nibu Ken-ichi
    日本耳鼻咽喉科学会, Oct. 2016, 日本耳鼻咽喉科学会会報, 119(10号) (10号), 1344 - 1346, Japanese
    Introduction scientific journal

  • Ohtsuki Naoki, Nibu Ken-ichi
    (株)医学書院, Oct. 2016, 耳鼻咽喉科・頭頸部外科, 88(11号) (11号), 814 - 820, Japanese
    [Invited]
    Introduction scientific journal

  • 【頸部郭清術のNew Concept】 手術手技 咽頭後リンパ節郭清
    四宮弘隆, Nibu Ken-ichi
    Oct. 2016, 耳鼻咽喉科・頭頸部外科, 88(11号) (11号), 852 - 856, Japanese
    [Invited]
    Introduction commerce magazine

  • K Thomas Robbins, Carol R Bradford, Juan P Rodrigo, Carlos Suárez, Remco de Bree, Luiz P Kowalski, Alessandra Rinaldo, Carl E Silver, Valerie J Lund, Ken-Ichi Nibu, Alfio Ferlito
    Importance: The surgical dictum of en bloc resection without violating cancer tissue has been challenged by novel treatments in head and neck cancer. Observations: An analysis of treatment outcomes involving piecemeal removal of sinonasal, laryngeal, oropharyngeal, and hypopharyngeal cancer shows that it did not compromise tumor control. The rationale for the evolution toward use of this technique is outlined. Conclusions and Relevance: While complete resection with clear margins remains a key end point in surgical oncology, we believe it is time to acknowledge that this time-honored dictum of avoiding tumor violation is no longer valid in selected situations.
    01 Oct. 2016, JAMA otolaryngology-- head & neck surgery, 142(10) (10), 1010 - 1013, English, International magazine
    [Refereed]

  • 当科における難聴遺伝子解析の検討
    上原 奈津美, 山下 大介, 堀地 祐人, 勝沼 紗矢香, 柿木 章伸, 丹生 健一, 西尾 信哉, 宇佐美 真一
    (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 624 - 624, Japanese

  • 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害
    藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美
    (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese

  • 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害
    藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美
    (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese

  • 副甲状腺腺腫からの出血により深頸部縦隔血腫をきたした1例
    本郷裕斗, 河野圭志, 大月直樹, 岡田卓也, Fujii Hideki, 森田成彦, 丹生健一, 西慎一
    (一社)日本腎臓学会, Aug. 2016, 日本腎臓学会誌, 58(6号) (6号), 922 - 922, Japanese
    Meeting report

  • 【頸部腫瘤を見極める】 頸部腫瘤の鑑別診断
    Nibu Ken-ichi
    Aug. 2016, 耳鼻咽喉科・頭頸部外科, 88(9号) (9号), 622 - 624, Japanese
    [Invited]
    Introduction commerce magazine

  • 【イチから学ぶ!頭頸部再建の基本】 頭頸部再建に必要な腫瘍切除の基本
    Nibu Ken-ichi
    全日本病院出版会, May 2016, PEPARS, (113号) (113号), 19 - 25, Japanese
    Introduction commerce magazine

  • Ohtsuki Naoki, Nibu Ken-ichi
    (株)全日本病院出版会, Apr. 2016, ENTONI, (192号) (192号), 155 - 160, Japanese
    [Invited]
    Introduction commerce magazine

  • 【耳鼻咽喉科処方マニュアル】 麻痺・痛み・異常感 嗅覚障害
    藤尾久美, Nibu Ken-ichi
    Apr. 2016, 耳鼻咽喉科・頭頸部外科, 88(5号) (5号), 258 - 261, Japanese
    [Invited]
    Introduction commerce magazine

  • Ohtsuki Naoki, Nibu Ken-ichi
    (株)医学書院, Apr. 2016, 耳鼻咽喉科・頭頸部外科, 88(5号) (5号), 151 - 153, Japanese
    [Invited]
    Introduction commerce magazine

  • Ohtsuki Naoki, Nibu Ken-ichi
    (株)東京医学社, Mar. 2016, JOHNS, 32(3号) (3号), 371 - 374, Japanese
    [Invited]
    Introduction commerce magazine

  • Bulletin 第4回アジア頭頸部癌学会(ASHNO 2015)報告
    大月 直樹, 丹生 健一
    メディカルレビュー社, Dec. 2015, 頭頸部癌frontier, 3(2) (2), 170 - 172, Japanese

  • 【漢方薬を使いこなす】 疾患・症候への処方の実際 嗅覚障害
    藤尾久美, Nibu Ken-ichi
    Dec. 2015, 耳鼻咽喉科・頭頸部外科, 87(13号) (13号), 1092 - 1093, Japanese
    [Invited]
    Introduction scientific journal

  • Radiation Therapy for T3/T4 Squamous Cell Carcinoma of Hypopharynx: A Retrospective Comparison Between Definitive Radiation Therapy and Surgery Followed by Postoperative Radiation Therapy
    Y. Matsuo, K. Yoshida, D. Miyawaki, Y. Ejima, T. Ishihara, R. Nishikawa, N. S. Sulaiman, Y. Inoue, H. Nishimura, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
    Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E341 - E342, English
    Summary international conference

  • 【これだけは知っておこう-鼻出血への対応法】《疾患》 遺伝性出血性毛細血管拡張症関連鼻出血
    Inokuchi Gou, 高原慎一, 藤尾久美, Nibu Ken-ichi
    Nov. 2015, 耳鼻咽喉科・頭頸部外科, 87(12号) (12号), 996 - 1002, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi
    The Oto-Rhino-Laryngological Society of Japan, Inc., Oct. 2015, 日本耳鼻咽喉科学会会報, 118(10号) (10号), 1272 - 1276, Japanese
    [Invited]
    Introduction scientific journal

  • 【見逃されやすい頸部リンパ節腫脹の原因疾患】 頸部リンパ節結核
    Morimoto Koichi, Nibu Ken-ichi
    科学評論社, Sep. 2015, 血液内科, 71(3号) (3号), 363 - 366, Japanese
    Introduction scientific journal

  • 【機能温存を考慮した頭頸部癌治療-口腔癌(舌癌)・咽頭癌・喉頭癌を中心に-】 Evidence Based Medicine 各ガイドラインにおける機能温存の考え方 頭頸部癌診療ガイドラインにおける臓器温存の考え方
    Nibu Ken-ichi
    メディカルレビュー社, Aug. 2015, 頭頸部癌Frontier, 3(1号) (1号), 60 - 62, Japanese
    Introduction commerce magazine

  • 【頭蓋底外科の進歩-オープンサージェリーと内視鏡下手術】 頭蓋底外科の歴史 オープンサージェリーから内視鏡手術まで
    Nibu Ken-ichi, Inokuchi Gou, 四宮弘隆
    Jul. 2015, JOHNS, 31(7号) (7号), 827 - 830, Japanese
    [Invited]
    Introduction commerce magazine

  • 中咽頭癌に対する化学放射線療法におけるPEGの有用性
    高橋 美貴, 小坂 奈々, 宇佐美 眞, 中川 絵美, 齋藤 幹, 大月 直樹, 佐々木 良平, 清田 尚臣, 丹生 健一
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 250 - 250, Japanese

  • 中・下咽頭後壁癌に対する放射線治療成績
    宮脇 大輔, 江島 泰生, 吉田 賢史, 石原 武明, 清田 尚臣, 斉藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese

  • 食道癌同時合併中下咽頭癌に対する放射線治療の経験
    西川 遼, 吉田 賢史, 宮脇 大輔, 江島 泰生, 石原 武明, 松尾 佳朗, ノル・シャズリナ, 井上 由子, 西村 英輝, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 254 - 254, Japanese

  • 原発不明癌頸部リンパ節転移に対する放射線治療の経験
    井上 由子, 吉田 賢史, 江島 泰生, 宮脇 大輔, 石原 武明, ノル・シャズリナ, 西川 遼, 松尾 圭朗, 西村 英輝, 大月 直樹, 斎藤 幹, 清田 尚臣, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 262 - 262, Japanese

  • N3頸部リンパ節転移症例に対する放射線治療の経験
    吉田 賢史, 宮脇 大輔, 江島 泰生, 西村 英輝, 石原 武明, 松尾 佳朗, 西川 遼, 井上 由子, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 266 - 266, Japanese

  • 頭頸部粘表皮癌に対する粒子線(炭素線・陽子線)治療
    美馬 正幸, 出水 祐介, 金 東村, 高木 克, 永野 史子, 寺嶋 千貴, 藤井 收, 沖本 智昭, ノル・シャズリナ, 脇 隆博, 丹羽 康江, 森本 浩一, 佐々木 良平, 丹生 健一, 不破 信和
    (一社)日本頭頸部癌学会, May 2015, 頭頸部癌, 41(2) (2), 267 - 267, Japanese

  • 柴田 智久, 藤田 岳, 小嶋 康隆, 井之口 豪, 山下 大介, 長谷川 信吾, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2015, 日本耳鼻咽喉科学会会報, 118(4) (4), 482 - 482, Japanese

  • Nibu Ken-ichi
    Apr. 2015, 頭頸部癌, 41(1号) (1号), 23 - 25, Japanese
    Introduction scientific journal

  • 【こんなときの対応法がわかる 耳鼻咽喉科手術ガイド】 頸部の手術 副咽頭間隙腫瘍に対する手術
    四宮弘隆, Nibu Ken-ichi
    Apr. 2015, 耳鼻咽喉科・頭頸部外科, 87(5号) (5号), 264 - 267, Japanese
    [Invited]
    Introduction scientific journal

  • 【こんなときの対応法がわかる 耳鼻咽喉科手術ガイド】 喉頭・下咽頭の手術 下咽頭梨状陥凹瘻に対する手術
    Ohtsuki Naoki, Nibu Ken-ichi
    Apr. 2015, 耳鼻咽喉科・頭頸部外科, 87(5号) (5号), 206 - 209, Japanese
    [Invited]
    Introduction scientific journal

  • Nibu Ken-ichi, 岸本誠司, 藤井博文, 梅野博仁, 古平毅, 松浦一登, 朝蔭孝宏
    (NPO)日本気管食道科学会, Apr. 2015, 日本気管食道科学会会報, 66(2号) (2号), 137 - 142, Japanese
    [Invited]
    Introduction commerce magazine

  • 頭頸部傍神経節腫に対する放射線治療の経験
    酒井 徹也, 江島 泰生, 吉田 賢史, 宮脇 大輔, 上薗 玄, 松本 葉子, ノル・シャズリナ, 松尾 圭朗, 佐々木 良平, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese

  • 鼻腔・副鼻腔腫瘍の治療計画における不均質補正の影響
    椋本 成俊, 吉田 賢史, 赤坂 浩亮, 江島 泰生, 宮脇 大輔, 上薗 玄, 佐々木 良平, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 70 - 70, Japanese

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    下山 真介, 上薗 玄, 松尾 圭朗, ノル・シャズリナ, 松本 葉子, 宮脇 大輔, 吉田 賢史, 江島 泰生, 佐々木 良平, 清田 尚臣, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2015, Japanese Journal of Radiology, 33(Suppl.) (Suppl.), 76 - 76, Japanese

  • Nibu Ken-ichi
    Jan. 2015, 日本耳鼻咽喉科学会会報, 118(1号) (1号), 80 - 81, Japanese
    [Refereed]
    Introduction scientific journal

  • 術前FDG-PET/CTによる咽頭癌、咽頭癌の頸部リンパ節転移診断 CTとの対比
    末永 裕子, 北島 一宏, 河野 淳, 奥永 崇志, 武田 英治, 久保 和広, 丹生 健一, 佐々木 良平, 伊藤 智雄, 杉村 和朗
    (一社)日本核医学会, Nov. 2014, 核医学, 51(4) (4), 443 - 443, Japanese

  • 色素性乾皮症における聴覚障害の検討
    Yamashita Daisuke, Fujita Takeshi, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi
    Oct. 2014, 第24回日本耳科学会総会・学術講演会, Japanese
    [Invited]
    Summary national conference

  • Nibu Ken-ichi
    CBTの治療選択にあたっては，CT，MRI，血管造影などの画像検査で，腫瘍と頸動脈との位置関係を十分に把握して手術のリスクを評価し，年齢，増大速度，合併する神経症状，単発か多発か，などを含め，個別に治療方針を検討する必要がある。放射線単独治療と経過観察でも比較的経過は良好であり，手術困難例ではこれらの治療方針も考慮する。一方でCBTの約5%に悪性がみられるとされ，念頭におく必要がある。
    JAPAN SOCIETY FOR HEAD AND NECK SURGERY, Oct. 2014, 頭頸部外科, 24(2号) (2号), 127 - 130, Japanese
    Introduction scientific journal

  • 【神経をどう扱うか】 手術等での取り扱い 嗅球、嗅神経、嗅上皮
    Inokuchi Gou, Nibu Ken-ichi
    Oct. 2014, JOHNS, 30(10号) (10号), 1418 - 1420, Japanese
    [Invited]
    Introduction commerce magazine

  • Result of Multimodal Treatment Including Radiation Therapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    D. Miyawaki, Y. Ejima, H. Uezono, K. Yoshida, H. Nishimura, N. Otsuki, K. Nibu, R. Sasaki
    Sep. 2014, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 90, S544 - S544, English
    Summary international conference

  • 治療前FDG-PETによる喉頭癌の再発予測
    北島 一宏, 末永 裕子, 奥永 崇志, 久保 和広, 佐々木 良平, 丹生 健一, 清田 尚臣, 杉村 和朗
    (一社)日本核医学会, Sep. 2014, 核医学, 51(3) (3), 265 - 265, Japanese

  • 術前FDG-PET/CTによる咽頭癌、喉頭癌の頸部リンパ節転移診断 CTとの対比
    末永 裕子, 北島 一宏, 河野 淳, 奥永 崇志, 武田 英治, 久保 和広, 丹生 健一, 佐々木 良平, 伊藤 智雄, 杉村 和朗
    (一社)日本核医学会, Sep. 2014, 核医学, 51(3) (3), 265 - 265, Japanese

  • E10A, AN ADENOVIRUS CARRYING ENDOSTATIN GENE, DRAMATICALLY INCREASED THE TUMOR DRUG CONCENTRATION OF METRONOMIC CHEMOTHERAPY WITH LOW DOSE CISPLATIN IN A XENOGRAFT MOUSE MODEL FOR HEAD AND NECK SQUAMOUS CELL CARCINOMA
    Zainal Adhim, Xubin Lin, Wenlin Huang, Tsutomu Nakamura, Hiroyuki Yasui, Naoki Otsuki, Ken-ichi Nibu, Masato Fujisawa, Toshiro Shirakawa
    Jul. 2014, JOURNAL OF GENE MEDICINE, 16(7-8) (7-8), 238 - 239, English
    Summary international conference

  • 【鼻の疑問に答える】 嗅覚についての疑問 においの感覚に異常がでる神経変性疾患は?
    Fujio Kumi, 福田 有里子, Inokuchi Gou, 長谷川 信吾, Nibu Ken-ichi
    Jul. 2014, JOHNS, 30(7号) (7号), 885 - 888, Japanese
    [Invited]
    Introduction commerce magazine

  • 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討
    筧康正, 南川勉, 小松弘和, 齋藤幹, 渋谷恭之, 大月直樹, 丹生健一, 古森孝英
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 229 - 229, Japanese

  • 頭頸部進行がんに対する治療戦略 進行期喉頭癌・下咽頭癌に対する治療戦略
    大月 直樹, 四宮 弘隆, 小松 弘和, 森本 浩一, 齋藤 幹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 148 - 148, Japanese

  • T3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討
    佐々木 良平, 松尾 圭朗, 江島 泰生, 宮脇 大輔, 上薗 玄, 今村 善宣, 清田 尚臣, 四宮 弘隆, 小松 弘和, 森本 浩一, 斉藤 幹, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 155 - 155, Japanese

  • 免疫組織化学染色による唾液腺導管癌15例の検討
    今村 善宣, 清田 尚臣, 大月 直樹, 山下 大介, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 186 - 186, Japanese

  • 当科における中咽頭癌症例の臨床的検討
    四宮 弘隆, 四宮 瞳, 小松 弘和, 森本 浩一, 齋藤 幹, 大月 直樹, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 195 - 195, Japanese

  • 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象
    高橋 美貴, 小坂 奈々, 宇佐美 眞, 中川 絵美, 齋藤 幹, 大月 直樹, 江島 泰生, 宮脇 大輔, 佐々木 良平, 清田 尚臣, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 238 - 238, Japanese

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 江島 泰生, 上薗 玄, 四宮 弘隆, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 264 - 264, Japanese

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    上薗 玄, 江島 泰生, 宮脇 大輔, 四宮 弘隆, 小松 弘和, 藤尾 久美, 森本 浩一, 今村 善宣, 斉藤 幹, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2014, 頭頸部癌, 40(2) (2), 265 - 265, Japanese

  • 【画像診断パーフェクトガイド 読影のポイントとピットフォール】 部位別診断法 頭頸部 副咽頭間隙腫瘍
    四宮 弘隆, Nibu Ken-ichi
    Apr. 2014, 耳鼻咽喉科・頭頸部外科, 86(5号) (5号), 296 - 301, Japanese
    Introduction scientific journal

  • Hearing loss in Xeroderma pigmnetosum and mechanism of inner ear disorder.
    Yamashita Daisuke, Fujita Takeshi, Masaki Taro, Takeuchi Seiji, Ueda Takehiro, Sakai Yoshitada, Nakagawa Taku, Toyoshima Daisaku, Morisada Naoya, Kanda Fumio, Nishigori Chikako
    Mar. 2014, International Symposium on Xeroderma Pigmentosum and Related Disease, English
    Summary national conference

  • 喉頭原発悪性リンパ腫に対する放射線治療の経験
    井上 由子, 吉田 賢史, 宮脇 大輔, 西村 英輝, 原田 文, 村岡 修, ノル・シャズリナ, 佐々木 良平, 岡村 篤夫, 斎藤 幹, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2014, Japanese Journal of Radiology, 32(Suppl.) (Suppl.), 36 - 36, Japanese

  • 当院における唾液腺導管癌15例の臨床病理学的検討
    今村善宣, 清田尚臣, 大月直樹, 平井千浦子, 豊田昌徳, 茶屋原菜穂子, 船越洋平, 向原徹, 丹生健一, 南博信
    2014, 日本内科学会雑誌, 103

  • Radiation-Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison Between Concurrent Chemoradiation Therapy and Radiation Therapy Alone
    D. Miyawaki, K. Yoshida, Y. Ejima, H. Nishimura, N. S. Sulaiman, N. Kiyota, M. Saito, N. Otsuki, K. Nibu, R. Sasaki
    Oct. 2013, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 87(2) (2), S472 - S473, English
    Summary international conference

  • Iwata Kentaro, 北村 聖, Kanazawa Kenji, Nibu Ken-ichi, Kanda Fumio
    Introduction: Kobe University Hospital's faculty development workshop was unattractive, and people attended it passively.
    Methods: We attempted to improve the workshop so that faculty would want to attend it independently and proactively. In this report we summarize the changes in the workshop and report the results of questionnaires administered before （2008） and after （2012） the change.
    Results: Overall contents of the faculty development workshop became more open, and such practices as the Kawakita Jiro method stopped being used. Overall scores for participant satisfaction improved significantly from 2008 to 2012, but the duration of the workshop did not change significantly.
    Discussion: We improved the quality of the faculty development workshop and increased participant satisfaction. We should continue to improve the workshop through proper assessment.
    Japan Society for Medical Education, Oct. 2013, 医学教育, 44(5号) (5号), 358 - 363, Japanese
    [Refereed]
    Introduction scientific journal

  • 25-year experience with primary major salivary gland carcinoma at a single institution in Japan
    Y. Imamura, N. Kiyota, N. Otsuki, C. Hirai, Y. Funakoshi, T. Mukohara, D. Yamashita, T. Ito, K. Nibu, H. Minami
    Sep. 2013, EUROPEAN JOURNAL OF CANCER, 49, S753 - S753, English
    Summary international conference

  • Interview 頭頸部癌診療ガイドライン(2013年版)改訂について (特集 化学療法の進歩と展開 : Head & Neck Summit 2012を中心に) -- (Key Topics)
    丹生 健一
    メディカルレビュー社, Sep. 2013, 頭頸部癌frontier, 1(2) (2), 154 - 156, Japanese

  • 【見落としやすい耳鼻咽喉科疾患】 咽頭 下咽頭梨状陥凹瘻
    Ohtsuki Naoki, Nibu Ken-ichi
    Sep. 2013, ENTONI, (157号) (157号), 95 - 99, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 【化学療法の進歩と展開-Head & Neck Summit 2012を中心に-】 頭頸部癌診療ガイドライン
    Nibu Ken-ichi
    メディカルレビュー社, Sep. 2013, 頭頸部癌Frontier, 1(2号) (2号), 150 - 153, Japanese
    Introduction commerce magazine

  • 【甲状腺・副甲状腺診療Update】 分化型甲状腺癌診療における遺伝子組換えヒト甲状腺刺激ホルモン製剤の役割
    Ohtsuki Naoki, Nibu Ken-ichi
    Jul. 2013, 耳鼻咽喉科・頭頸部外科, 85(8号) (8号), 588 - 591, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 【下咽頭癌はここまで治る】 再発例に対する救済治療はどこまで可能か 術後再発例に対する救済治療
    Ohtsuki Naoki, 齋藤 幹, Nibu Ken-ichi
    Jun. 2013, JOHNS, 29(6号) (6号), 1029 - 1033, Japanese
    [Invited]
    Introduction commerce magazine

  • 鼻腔原発NK/T細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村 英輝, Ejima Yasuo, 吉田 賢史, Yakushijin Kimikazu, 松岡 広, 土井 清司, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 264 - 264, Japanese
    Meeting report

  • 下顎切除患者における発色ガム検査の有用性
    石田 優, 渋谷 恭之, 小林 正樹, 丹生 健一, 古森 孝英
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2) (2), 191 - 191, Japanese

  • 頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, 吉田 賢史, Ejima Yasuo, 西村 英輝, 岡本 欣晃, Kiyota Naomi, 斉藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 262 - 262, Japanese
    Meeting report

  • 当院におけるT3喉頭癌の放射線治療の経験
    松尾 圭朗, 吉田 賢史, Miyawaki Daisuke, Ejima Yasuo, Kiyota Naomi, 斎藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 186 - 186, Japanese
    Meeting report

  • 進行舌癌に対する術後放射線治療の経験
    吉田 賢史, Miyawaki Daisuke, Ejima Yasuo, 西村 英輝, Kiyota Naomi, 南川 勉, 斉藤 幹, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 250 - 250, Japanese
    Meeting report

  • 耳下腺癌/顎下腺癌術後症例に対する放射線治療の検討
    村岡 修, Miyawaki Daisuke, 西村 英輝, 吉田 賢史, Ejima Yasuo, 大月 直樹, Morimoto Koichi, 山下 大介, 丹生 健一, 岡本 欣晃, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 233 - 233, Japanese
    Meeting report

  • 甲状腺原発MALTリンパ腫の治療経験
    Ejima Yasuo, 吉田 賢史, Miyawaki Daisuke, 西村 英輝, 岡本 欣晃, 副島 俊典, 松岡 広, 大月 直樹, 丹生 健一, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 237 - 237, Japanese
    Meeting report

  • 5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討
    Sasaki Ryohei, Ejima Yasuo, 吉田 賢史, Miyawaki Daisuke, 西村 英輝, 岡本 欣晃, 山下 大介, 長谷川 信吾, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 184 - 184, Japanese
    Meeting report

  • T1/2声門上癌に対する放射線治療成績の検討
    松本 葉子, 吉田 賢史, Ejima Yasuo, Miyawaki Daisuke, 西村 英輝, 斉藤 幹, 大月 直樹, 丹生 健一, Kiyota Naomi, Sasaki Ryohei
    (一社)日本頭頸部癌学会, May 2013, 頭頸部癌, 39(2号) (2号), 264 - 264, Japanese
    Meeting report

  • Ohtsuki Naoki, Nibu Ken-ichi
    The Society of Practical Otolaryngology, Apr. 2013, 耳鼻咽喉科臨床, 106(4号) (4号), 296 - 297, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 【急患・急変対応マニュアル-そのとき必要な処置と処方】 救急・急変対応の心得 救急搬送をする際,受ける際のポイント
    Nibu Ken-ichi
    Apr. 2013, 耳鼻咽喉科・頭頸部外科, 85(5号) (5号), 14 - 15, Japanese
    [Invited]
    Introduction commerce magazine

  • 【プロに学ぶ手術所見の記載法】 外側側頭骨切除術、側頭骨亜全摘出術
    Hasegawa Shingo, Nibu Ken-ichi
    Apr. 2013, JOHNS, 29(4号) (4号), 683 - 689, Japanese
    [Invited]
    Introduction commerce magazine

  • 1年以上経過した迷走神経障害例に対する音声治療の試み
    Morimoto Koichi, Saito Miki, Nibu Ken-ichi
    Jan. 2013, 音声言語医学, 54(1号) (1号), 52 - 53, Japanese
    Meeting report

  • Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach
    H. Nishimura, R. Sasaki, K. Yoshida, D. Miyawaki, Y. Okamoto, N. Kiyota, M. Saito, N. Otsuki, K. Nibu
    Nov. 2012, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 84(3) (3), S491 - S491, English
    Summary international conference

  • A PILOT RANDOMIZED TRIAL COMPARING STANDARD PAIN CONTROL WITH OR WITHOUT GABAPENTIN FOR THE TREATMENT OF PAIN RELATED TO RADIATION-INDUCED MUCOSITIS IN HEAD AND NECK CANCER
    T. Kataoka, N. Kiyota, T. Shimada, Y. Imamura, N. Chayahara, M. Toyoda, Y. Funakoshi, H. Tomioka, Y. Fujiwara, K. Nibu, T. Komori, H. Nishimura, R. Sasaki, T. Mukohara, H. Minami
    Oct. 2012, ANNALS OF ONCOLOGY, 23, 91 - 91, English
    Summary international conference

  • 【高齢化社会と耳鼻咽喉科】 器官別機能と老化による病態 嗅覚
    Fujio Kumi, Doi Kiyoshi, Hasegawa Shingo, Nibu Ken-ichi
    Sep. 2012, JOHNS, 28(9号) (9号), 1295 - 1298, Japanese
    [Refereed]
    Introduction scientific journal

  • 【頭頸部扁平上皮癌の最新情報】 特殊な領域の扁平上皮癌 唾液腺の扁平上皮癌
    Ohtsuki Naoki, Itoh Tomoo, Nibu Ken-ichi
    Aug. 2012, JOHNS, 28(8号) (8号), 1217 - 1221, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • Nibu Ken-ichi, Ohtsuki Naoki, Kiyota Naomi
    分子標的治療薬とは, がん細胞に特異的な遺伝子, 蛋白などを標的として作られた薬剤のことである. これまでの抗がん剤が自然界に存在するさまざまな物質をがん細胞に与えては抗腫瘍効果をみるという「はじめに効き目ありき」の手法で開発されてきたのに対し, 分子標的薬は「はじめに作用機序ありき」で開発するところが大きく異なる. 従来の代表的な抗がん剤にも標的があったが, その標的は正常細胞の増殖や分裂に関与するため, がん細胞のみならず正常細胞にも同様に障害を与え, 白血球減少や下痢, 脱毛などの副作用を避けられなかった. これに対して分子標的治療薬は, まず腫瘍に特異的な標的に選択的に作用する物質を見つけ出すことから開発が始まるので, 正常細胞への影響が少なく, がん細胞に特異的に殺傷効果を与える薬剤が作りだされることが期待できる.
    製剤面からは膜 (貫通) 型チロシンキナーゼ (TK) 受容体に対する阻害剤のような低分子化合物と, 標的に対するモノクローナル抗体に大別される. 標的としては細胞表面抗原, 増殖因子, 増殖因子受容体, シグナル伝達系, 細胞周期・アポトーシス, 血管新生, がん遺伝子・がん抑制遺伝子などさまざまなものが候補となるが, 現時点で頭頸部癌に対して欧米で承認されている分子標的薬は, 頭頸部扁平上皮癌で過剰発現している膜貫通性TK, EGFRに対するキメラ型IgG1抗体Cetuximabのみである. 残念ながら本邦では未だ頭頸部癌に対しては承認されていないが, 大規模な臨床試験で, 中・下咽頭および喉頭の局所進行扁平上皮癌に対する放射線治療への上乗せ効果や, 遠隔転移・再発頭頸部扁平上皮癌に対するCDDP+5-FU療法への上乗せ効果が示されており, 一日も早い導入が望まれる.
    The Oto-Rhino-Laryngological Society of Japan, Inc., Jul. 2012, 日本耳鼻咽喉科学会会報, 115(7号) (7号), 671 - 675, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • AIDS患者の中咽頭扁平上皮癌に対する治療経験
    Fujita Takeshi, Yoshida Kenji, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    Jun. 2012, 第36回日本頭頸部癌学会, Japanese
    [Invited]
    Summary national conference

  • T1-T3N0声門癌の喉頭温存を目指した治療方針の検討
    原田 文, 宮脇 大輔, 吉田 賢史, 西村 英輝, 村岡 修, ノル・シャズリナ, 斉藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 191 - 191, Japanese

  • 患者の中咽頭扁平上皮癌に対する治療経験
    林 拓二, 藤田 岳, 吉田 賢史, 西村 英輝, 佐々木 良平, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 224 - 224, Japanese

  • 下顎骨区域切除後の再建法別QOLの比較検討
    石田 優, 渋谷 恭之, 小林 正樹, 丹生 健一, 古森 孝英
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 151 - 151, Japanese

  • 頭頸部癌患者における放射線性粘膜炎による疼痛に対するガバペンチンのパイロット・ランダム化比較試験
    片岡 智子, 清田 尚臣, 島田 貴信, 今村 善宣, 茶屋原 菜穂子, 豊田 昌徳, 船越 洋平, 富岡 秀夫, 藤原 豊, 丹生 健一, 古森 孝英, 西村 英輝, 佐々木 良平, 向原 徹, 南 博信
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 188 - 188, Japanese

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, 村岡 修, ノル・シャズリナ, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 195 - 195, Japanese

  • 顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験
    佐々木 良平, 西村 英輝, 吉田 賢史, 宮脇 大輔, 森本 浩一, 米澤 宏一郎, 大月 直樹, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 221 - 221, Japanese

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤 宏一郎, 森本 浩一, 山下 大介, 谷本 均, 斉藤 幹, 大月 直樹, 丹生 健一, 清田 尚臣, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 226 - 226, Japanese

  • 多診療科共同で集学的治療を行った頭頸部原発骨軟部肉腫の2例
    島田 貴信, 清田 尚臣, 米澤 宏一郎, 土井 清司, 長谷川 信吾, 西村 英輝, 佐々木 良平, 南川 勉, 橋川 和信, 田原 真一, 丹生 健一
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 231 - 231, Japanese

  • 鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験
    ノル・シャズリナ, 吉田 賢史, 西村 英輝, 宮脇 大輔, 原田 文, 村岡 修, 岡本 欣晃, 土井 清司, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 244 - 244, Japanese

  • 高齢頭頸部癌患者に対する放射線治療の経験 10年間の検討
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 原田 文, ノル・シャズリナ, 斎藤 幹, 大月 直樹, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 248 - 248, Japanese

  • 顎下腺癌に対する放射線療法の経験
    村岡 修, 宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, ノル・シャズリナ, 大月 直樹, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 267 - 267, Japanese

  • 鼻腔・副鼻腔腫瘍の切除と再建 鼻副鼻腔悪性腫瘍に対する手術治療 頭蓋底手術の紹介
    Doi Kiyoshi, Nibu Ken-ichi
    May 2012, 日本鼻科学会会誌, 51(1号) (1号), 86 - 88, Japanese
    [Refereed]
    Introduction scientific journal

  • 【小児の耳鼻咽喉科108の疑問】 顔面・頸部疾患 顔面の血管腫はどのように治療すべきか?
    Ejiri Hirotaka, Hashikawa Kazunobu, Nibu Ken-ichi
    Mar. 2012, JOHNS, 28(3号) (3号), 513 - 515, Japanese
    Introduction commerce magazine

  • Latest trends in the management of head and neck cancers in Japan (The 49th annual meeting of Japanese Society of Clinical Oncology educational book) -- (JSCO University: Head & neck cancer)
    Nibu Ken-ichi
    日本癌治療学会, 13 Sep. 2011, 日本癌治療学会誌, 46(3) (3), 1265 - 1267, English

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study
    D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, K. Sugimura, S. Hasegawa, K. Nibu, R. Sasaki
    Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S563 - S563, English
    Summary international conference

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 原田 文, 村岡 修, ノル・シャズリナ, 中山 雅央, 上原 和之, 赤坂 浩亮, 椋本 成俊, 土井 清司, 山下 大介, 長谷川 信吾, 丹生 健一, 佐々木 良平
    (一社)日本癌治療学会, Sep. 2011, 日本癌治療学会誌, 46(2) (2), 786 - 786, Japanese

  • エンドスタチン遺伝子導入による腫瘍内プラチナ濃度の増大
    中村 任, Adhim Zainal, Lin Xubin, Huang Wenlin, 安井 裕之, 大月 直樹, 丹生 健一, 藤澤 正人, 白川 利朗
    (公社)日本薬剤学会, May 2011, 日本薬剤学会年会講演要旨集, 26年会, 229 - 229, Japanese

  • 頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績
    森本 浩一, 出水 祐介, 寺嶋 千貴, 美馬 正幸, 藤井 收, 丹羽 康江, 宮脇 大輔, 佐々木 良平, 村上 昌雄, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 219 - 219, Japanese

  • 当科における顎下腺癌手術症例の検討
    大月 直樹, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 村岡 修, 宮脇 大輔, 吉田 賢史, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 245 - 245, Japanese

  • 当科における喉頭機能温存手術の検討
    米澤 宏一郎, 森本 浩一, 齋藤 幹, 大月 直樹, 清田 尚臣, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 249 - 249, Japanese

  • 上顎洞扁平上皮癌に対する放射線治療成績
    宮脇 大輔, 西村 英輝, 吉田 賢史, 村岡 修, 岡本 欣晃, 土井 清司, 山下 大介, 長谷川 信吾, 丹生 健一, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese

  • 遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討
    西村 英輝, 佐々木 良平, 吉田 賢史, 宮脇 大輔, 丹生 健一, 大月 直樹, 斉藤 幹, 清田 尚臣, 岡本 欣晃, 副島 俊典
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 257 - 257, Japanese

  • 切除不能頭頸部癌に対するSequential therapyの安全性に関する後向き研究
    島田 貴信, 清田 尚臣, 大月 直樹, 丹生 健一, 西村 英輝, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 258 - 258, Japanese

  • 耳下腺癌術後症例に対する放射線治療の経験
    村岡 修, 宮脇 大輔, 吉田 賢史, 西村 英輝, 柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 大月 直樹, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 303 - 303, Japanese

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    吉田 賢史, 西村 英輝, 宮脇 大輔, 村岡 修, 佐々木 良平, 清田 尚臣, 土井 清司, 長谷川 信吾, 丹生 健一
    (一社)日本頭頸部癌学会, May 2011, 頭頸部癌, 37(2) (2), 320 - 320, Japanese

  • 西村 英輝, 佐々木 良平, 吉田 賢史, 宮脇 大輔, 大月 直樹, 斉藤 幹, 清田 尚臣, 副島 俊典, 杉村 和朗, 丹生 健一
    (一社)日本頭頸部癌学会, Apr. 2011, 頭頸部癌, 37(1) (1), 62 - 66, Japanese

  • 耳下腺癌における予防的頸部郭清と術後放射線治療について
    柴田 智久, 米澤 宏一郎, 森本 浩一, 山下 大介, 大月 直樹, 西村 英輝, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, Apr. 2011, 頭頸部癌, 37(1) (1), 78 - 82, Japanese

  • 内耳移植細胞の生体内動態モニタリング法の確立
    山下 大介, 和多田 有紀子, 神崎 晶, 藤田 岳, 長谷川 信吾, 小川 郁, 丹生 健一
    耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 7 - 9, Japanese

  • 糖尿病モデルマウスにおける聴覚機能および内耳形態の検討
    藤田 岳, 山下 大介, 勝沼 紗矢香, 長谷川 信吾, 丹生 健一
    耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 13 - 16, Japanese

  • Chemoradiotherapy and salvage surgery for laryngeal and hypopharyngeal cancer
    NIBU Ken-ichi
    31 Mar. 2011, 口腔・咽頭科 = Stomato-pharyngology, 24(1) (1), 35 - 37, Japanese

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    宮脇 大輔, 西村 英輝, 吉田 賢史, 橋本 直樹, 村岡 修, 中山 雅央, 上原 和之, 菊川 久美子, 丹生 健一, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S297 - S297, Japanese

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    難波 富美子, 吉田 賢史, 西村 英輝, 宮脇 大輔, 橋本 直樹, 村岡 修, 佐々木 良平, 清田 尚臣, 長谷川 信吾, 丹生 健一
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S353 - S353, Japanese

  • 原発不明癌頸部リンパ節転移に対する治療経験
    村岡 修, 吉田 賢史, 西村 英輝, 宮脇 大輔, 清田 尚臣, 斎藤 幹, 大月 直樹, 丹生 健一, 岡本 欣晃, 佐々木 良平
    (公社)日本医学放射線学会, Feb. 2011, 日本医学放射線学会学術集会抄録集, 70回, S354 - S354, Japanese

  • 【ここまで変わった頸部郭清術】 特殊領域の頸部リンパ節郭清 適応と手技 咽頭後リンパ節
    Nibu Ken-ichi
    Feb. 2011, JOHNS, 27巻, 2号, pp. 205-208, Japanese
    Introduction scientific journal

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    D. Miyawaki, H. Nishimura, K. Yoshida, O. Muraoka, M. Nakayama, K. Uehara, S. Hasegawa, K. Nibu, K. Sugimura, R. Sasaki
    2011, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 81(2) (2), S523 - S524, English
    Summary international conference

  • 聴器扁平上皮癌に対する放射線治療経験
    中林 美日, 吉田 賢史, 佐々木 良平, 岡本 欣晃, 西村 英輝, 河辺 哲也, 長谷川 信吾, 斉藤 幹, 大月 直樹, 丹生 健一
    (公社)日本医学放射線学会, Jan. 2011, Japanese Journal of Radiology, 29(Suppl.I) (Suppl.I), 43 - 43, Japanese

  • Yutaka Tokumaru, Masato Fujii, Katsunari Yane, Takanori Hama, Kiyoto Shiga, Hiroyuki Mineta, Tomokazu Yoshizaki, Kenji Okami, Ichiro Ota, Shigeru Hirano, Muneyuki Masuda, Masashi Sugasawa, Torahiko Nakashima, Toyoyuki Hanazawa, Noriyuki Sakihama, Yuichiro Kuratomi, Ken-ichi Nibu, Hisayuki Kato, Yorihisa Imanishi, Taro Sugimoto, Shinsuke Suzuki, Yuichiro Sato
    日本頭頸部癌学会, 2011, Japanese Journal of Head and Neck Cancer, 37(3) (3), 398 - 404, Japanese

  • Nibu Ken-ichi
    The Oto-Rhino-Laryngological Society of Japan, Inc., Jan. 2011, 日本耳鼻咽喉科学会会報, 114巻, 1号, pp. 40-43(1) (1), 40 - 43, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi
    日本頭頸部外科学会が母体となり, 平成21年4月より耳鼻咽喉科専門医のサブスペシャルティーとして頭頸部がん専門医制度が発足した. 本制度の基本理念は, 耳鼻咽喉科・頭頸部外科に関する熟練した技能と高度の専門知識とともに, がん治療の共通基盤となる基本的知識と技術, 医療倫理を併せ持ち, 頭頸部がんの集学的治療を実践する能力を養成することにある. 頭頸部領域はQOLに大きく関わっており, 外科的治療, 薬物療法, 放射線治療などを組み合わせた治療が行われることが多い. 頭頸部がん専門医には, そのチームリーダーとしての役割が求められる. 診断から終末期まで, がん治療の全相における幅広い経験や知識, 患者とのコミュニケーション能力, そしてコーディネーターとしての調整能力が必要である. 一方, 外科的治療は依然として頭頸部がん治療の大きな柱であり, その治療を自ら担当する頭頸部がん専門医にとっては最も重要な能力である. 専門医の認定にあたっては, 頭頸部がんの入院治療100例以上, 頭頸部がんの手術経験50件以上 (術者として) に加え, 外科的治療の基本である頸部郭清術を特に重視し, 頸部郭清術を助手として20側以上・術者として20側以上と, 必要経験症例数を決定した. さらに, これらの技術を集中的に学べるように, 5年間の頭頸部がん診療研修中, 頭頸部がんの年間新患数100例以上の指定研修施設で2年間の研修を行うことを義務付けている. 本原稿執筆時点で, 257名が暫定指導医として, 127施設が指定研修施設として認定された. 昨年9月には第1回頭頸部がん専門医認定試験が行われ, 165名が受験した. 本制度の発足が, 頭頸部外科を目指す耳鼻咽喉科医の増加, 大学・施設横断的な頭頸部外科医育成システムの構築, 頭頸部癌診療施設の集約化など, 頭頸部がん診療の今後の発展につながることを大いに期待している.
    The Oto-Rhino-Laryngological Society of Japan, Inc., Jan. 2011, 日本耳鼻咽喉科学会会報, 114巻, 1号, pp. 7-14(1) (1), 7 - 14, Japanese
    [Refereed]
    Introduction scientific journal

  • INTRAVENOUS INJECTION OF THE CARRIER-CELL BASED ONCOLYTIC ADENOVIRUS SUPPRESSES THE GROWTH OF MULTIPLE LUNG TUMORS IN MOUSE SQUAMOUS CELL CARCINOMA MODEL
    Toshiro Shirakawa, Katsuyuki Hamada, Shunichi Kitajima, Chihomi Mitsuoka, Naya Saito, Tadayuki Matsuoka, Zainal Adhim, Shuji Terao, Akinobu Gotoh, Ken-ichi Nibu, Masato Fujisawa, Kyung-Mi Lee
    Dec. 2010, JOURNAL OF GENE MEDICINE, 12(12) (12), 1034 - 1035, English
    Summary international conference

  • 【味覚と嗅覚】 嗅覚の測定
    Nibu Ken-ichi
    Nov. 2010, Clinical Neuroscience, 28巻, 11号, pp. 1256-1257, Japanese
    Introduction scientific journal

  • 知っておきたい生理・病態の基礎 咀嚼の生理とその障害の病態
    Nibu Ken-ichi
    Oct. 2010, 耳鼻咽喉科・頭頸部外科, 82巻, 11号, pp. 783-788, Japanese
    Introduction scientific journal

  • 【好酸球関連の病変】 線維素性唾液管炎
    Nibu Ken-ichi
    Sep. 2010, 耳鼻咽喉科・頭頸部外科, 82巻, 10号, pp. 679-683, 679 - 683, Japanese
    Introduction scientific journal

  • 嗅上皮の形態形成と再生における細胞接着分子の機能
    勝沼紗矢香, 富樫英, 高井義美, 丹生健一
    30 Jul. 2010, 日本鼻科学会会誌, 49(3) (3), 289, Japanese

  • 新しく立ち上がった頭頸部がん専門医制度をめぐって 頭頸部がん専門医制度の設立まで
    Nibu Ken-ichi
    Jun. 2010, 頭頸部外科, 20巻, 1号, pp. 9-12, Japanese
    Introduction scientific journal

  • Ohtsuki Naoki, Nibu Ken-ichi
    The Society of Practical Otolaryngology, May 2010, 耳鼻咽喉科臨床, 103巻, 5号, pp. 410-411(5) (5), 410 - 411, Japanese
    [Refereed]
    Introduction scientific journal

  • 音響外傷性難聴に対するSA4503の内耳防御機能
    山下 大介, 松永 達雄, 藤田 岳, 長谷川 信吾, 丹生 健一
    (一社)日本耳鼻咽喉科学会, Apr. 2010, 日本耳鼻咽喉科学会会報, 113(4) (4), 396 - 396, Japanese

  • 【内科医のための耳鼻科疾患の診かたと治療】 内科医が留意すべき耳鼻科疾患の診断と治療、予防 患者の症状から見逃さないためのコツとポイント 頸部腫脹
    Nibu Ken-ichi
    Apr. 2010, Progress in Medicine, 30巻, 4号, pp. 1101-1104, Japanese
    Introduction scientific journal

  • Ohtsuki Naoki, Nibu Ken-ichi
    The Japan Broncho-esophagological Society, Apr. 2010, 日本気管食道科学会会報, 61巻, 2号, pp. 112-114(2) (2), 112 - 114, Japanese
    Introduction scientific journal

  • 白川利朗, アドヒム ザイナル, 松岡孝幸, 重村克己, 丹生健一, 川端眞人, 藤澤正人
    (一社)日本泌尿器科学会, Feb. 2010, 日本泌尿器科学会雑誌, 101(2) (2), 250 - 250, Japanese

  • Ken-ichi Nibu, Yasuhiro Ebihara, Mitsuru Ebihara, Kazuyoshi Kawabata, Tetsuro Onitsuka, Takashi Fujii, Masahisa Saikawa
    Feb. 2010, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 15(1) (1), 33 - 38, English
    Introduction scientific journal

  • Ken-Ichi Nibu
    Society of Practical Otolaryngology, 2010, Practica Oto-Rhino-Laryngologica, 103(6) (6), 507 - 513, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科専門研修をはじめる医師へ 知っておきたい臨床解剖】 外耳道全摘出術
    Nibu Ken-ichi
    Dec. 2009, 耳鼻咽喉科・頭頸部外科, 81巻, 13号, pp. 899-904, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科診療におけるヒヤリ・ハット】 診断過程におけるヒヤリ・ハット 頸部腫瘤
    Nibu Ken-ichi
    (株)全日本病院出版会, Dec. 2009, ENTONI, 巻, 109号, pp. 20-25(109) (109), 53 - 61, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi, Ohtsuki Naoki
    頭頸部癌治療における最新の医療技術について, 手術手技を中心に紹介した.
    Supracricoid Laryngectomyは輪状軟骨より上部の喉頭組織を甲状軟骨とともに一塊切除するもので, 進行癌に対する初回治療としても救済手術としても画期的な術式である. 誤嚥の問題が心配されるが, 根治性は高く, 従来の喉頭温存切除術と比べて術後音声も遜色ない.
    拡張型喉頭鏡で術野を確保し, ハイビジョン内視鏡によりモニターを見ながら腫瘍を切除する経口的喉頭・下咽頭部分切除術は, 鮮明な視野が得られ, 早期の声門上癌やNBI内視鏡の普及により急増してきた咽頭表在癌の切除に有望な治療法である. 専用の機器がない場合は, 鼻内手術用内視鏡を代用できる.
    化学放射線療法は, 原発巣に比べて頸部リンパ節転移への効果が乏しく, 原発巣のみ化学放射線療法での治癒を期待し, 頸部リンパ節転移については計画的に頸部郭清術を行うという治療戦略planned neck dissectionが本邦でも普及しつつある. 創傷治癒障害, 喉頭咽頭の浮腫, 嚥下障害などの問題があり, 手術の適応や時期, 郭清範囲の検討が今後の課題となっている.
    今や鼻副鼻腔炎の標準的手術方法となった内視鏡下手術は, 腫瘍性病変にも応用されるようになってきた. 主な対象は内反性乳頭腫などの良性腫瘍だが, 悪性腫瘍に対しても, 開頭手術に手術支援ナビゲーション・システムと鼻内内視鏡を併用することにより, 頭蓋底や眼窩内側の良好な視野が得られ, 顔面の皮膚切開も最小限にとどめることができ, 内視鏡支援下手術の効用は大きい. 今後, 前頭蓋底手術の標準的な手術手技となっていくと思われる.
    The Oto-Rhino-Laryngological Society of Japan, Inc., Nov. 2009, 日本耳鼻咽喉科学会会報, 112巻, 11号, pp. 735-736,np1-np(11) (11), 735 - 738, Japanese
    Introduction scientific journal

  • Treatment outcomes for squamous cell carcinoma of the external auditory canal and middle ear
    K. Yoshida, M. Nakabayashi, R. Sasaki, H. Nishimura, Y. Okamoto, T. Kawabe, S. Hasegawa, N. Otsuki, K. Nibu, K. Sugimura
    Sep. 2009, EJC SUPPLEMENTS, 7(2) (2), 488 - 488, English
    Summary international conference

  • コ・メディカル教育 6大学連携オンコロジーチーム養成プランでのがん専門薬剤師養成コースの活動と現状
    西田 升三, 平井 みどり, 門林 宗男, 福岡 正博, 中川 和彦, 西村 恭昌, 平川 弘聖, 日野 雅之, 工藤 新三, 仲田 文造, 細野 雅子, 松井 徳造, 田中 京子, 高辻 功一, 丹生 健一, 佐々木 良平, 西村 善博, 南 博信, 中野 孝司, 廣田 省三, 長谷川 誠紀, 村川 和重, 一瀬 理加, 鈴木 志津枝, 安藤 悦子
    (一社)日本癌治療学会, Sep. 2009, 日本癌治療学会誌, 44(2) (2), 332 - 332, Japanese

  • Ohtsuki Naoki, Nibu Ken-ichi
    There is ample evidence to indicate that the use of concurrent chemoradiotherapy (CCRT) has improved larynx preservation outcomes in recent years not only for early but also for advanced laryngeal cancer, without compromising local disease control. Several randomized controlled trials have been performed in western countries to assess the impact of CCRT on larynx preservation. Although CCRT is considered to be the standard organ-preservation treatment for patients with advanced laryngeal cancer, the occurrence of early and late severe toxicity such as persistent dysphagia and aspiration after CCRT and complications in salvage surgery has been reported recently. A thorough discussion followed by obtaining informed consent regarding the risks and benefits of larynx-preservation therapy (CCRT or larynx-preservation surgery) has thus become crucial in the treatment of laryngeal cancer patients.
    JAPAN SOCIETY FOR HEAD AND NECK SURGERY, Jun. 2009, 頭頸部外科, 19巻, 1号, pp. 5-11(1) (1), 5 - 11, Japanese
    Introduction scientific journal

  • Intravenous Injection of Allogeneic Tumor Cell Vaccine Carrying Oncolytic Adenovirus (AdE3-IAI.3B) Suppresses the Growth of Multiple Lung Tumors in Mouse Squamous Cell Carcinoma Model
    Toshiro Shirakawa, Katsuyuki Hamada, Shunichi Kitajima, Chihomi Mitsuoka, Naoya Morishita, Norie Yamaoka, Aya Saito, Tadayuki Matsuoka, Zainal Adhim, Shuji Terao, Akinobu Gotoh, Ken-ichi Nibu, Masato Fujisawa, Kyung-Mi Lee, Wenlin Huang
    May 2009, MOLECULAR THERAPY, 17, S159 - S159, English
    Summary international conference

  • Olfactory Evaluation Using a Self-Administered Odor Questionnaire
    TSUZUKI Kenzo, FUKAZAWA Keijiro, TAKEBAYASHI Hironori, OKA Hideki, MIWA Takaki, KURONO Yuichi, NIBU Kenichi, MATSUNE Shoji, UCHIDA Jun, KOBAYASHI Masayoshi, OHTA Yasushi, SHIGA Hideaki, KOBAYAKAWA Tatsu, SAKAGAMI Masafumi
    01 Apr. 2009, 日本鼻科学会会誌, 48(1) (1), 1 - 7, Japanese

  • 頭頸部がんに対する放射線治療に伴う摂食・嚥下障害のリハビリテーション (特集 がん患者の放射線療法と看護)
    常行 美貴, 齋藤 幹, 丹生 健一
    南江堂, Mar. 2009, がん看護, 14(3) (3), 389 - 393, Japanese

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    K. Yoshida, R. Sasaki, M. Nakabayashi, H. Nishimura, Y. Okamoto, T. Kawabe, S. Hasegawa, N. Otsuki, K. Nibu, K. Sugimura
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S424 - S424, English
    Summary international conference

  • Radiotherapy for Locally Advanced Hypopharyngeal Carcinoma - A Comparison between Definitive (Chemo-) Radiotherapy and Laryngectomy followed by Postoperative Radiotherapy
    H. Nishimura, R. Sasaki, Y. Okamoto, K. Yoshida, T. Kawabe, K. Nibu, N. Ohtsuki, M. Saitoh, T. Soejima, K. Sugimura
    2009, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 75(3) (3), S418 - S418, English
    Summary international conference

  • 【感覚器のアンチエイジング】 嗅覚の加齢とアンチエイジング
    Nibu Ken-ichi
    メディカルレビュー社, Oct. 2008, アンチ・エイジング医学, 4巻, 5号, pp. 625-628(5) (5), 625 - 628, Japanese
    Introduction scientific journal

  • 【感覚器の再生医療】 嗅覚の再生医療 嗅上皮の再生に向けて
    Nibu Ken-ichi
    Sep. 2008, 医学のあゆみ, 226巻, 11号, pp. 991-995, Japanese
    Introduction scientific journal

  • 頭頸部癌 遺伝子診断・治療の現況
    Ohtsuki Naoki, Nibu Ken-ichi
    Jul. 2008, 癌と化学療法, 35巻, 7号, pp. 1126-1131, Japanese
    Introduction scientific journal

  • 【社会の変化と耳鼻咽喉科】 日常生活環境の変化 飲酒、喫煙と発癌
    Saito Miki, Nibu Ken-ichi
    Jun. 2008, JOHNS, 24巻, 6号, pp. 927-931, Japanese
    Introduction scientific journal

  • 【手術局所解剖アトラス】 頸部領域 喉頭・下咽頭・頸部食道
    Nibu Ken-ichi
    金原出版, May 2008, 手術, 62巻, 6号, pp. 683-689(6) (6), 677 - 682, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi
    (株)東京医学社, Apr. 2008, JOHNS, 24巻, 4号, pp. 608-612(4) (4), 621 - 624, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi
    嗅神経細胞は元来,「生涯にわたって再生を繰り返す」という神経細胞としては極めてユニークな性質を持っており, 再生医療の実現性が高いと期待される. 嗅上皮には様々なサイトカイン受容体が発現しており, 嗅神経細胞の再生あるいは生命維持にこれらのサイトカインが必要であると考えられている. 既に神経栄養因子であるNGFやBDNF遺伝子の鼻腔投与による嗅神経細胞のアポトーシス抑制効果がマウスにおいて報告されているが, 著者らは維芽細胞成長因子bFGFの鼻腔投与により, 特に高齢のマウスにおいて基底細胞の増殖を有意に促すことを見出した. アデノウイルスは様々な分野において遺伝子導入に利用されている優れた遺伝子導入ベクターである. 著者らはアデノウイルスベクターを鼻腔に投与することにより, ベクターに組み込んだ遺伝子の産物が嗅神経細胞において産生され, 軸索を通じて嗅覚の一次中枢である嗅球まで運ばれることを示し, アデノウイルスベクターが嗅神経細胞へのみならず嗅球へのドラッグデリバリーシステムとしても有用であることを報告した. 更にbcl-2遺伝子を組み込んだアデノウイルスベクターをマウス嗅上皮障害モデルの鼻腔に投与しbcl-2遺伝子が嗅神経細胞のアポトーシスを抑制する可能性を示した. 骨髄内にある血球以外の細胞群「骨髄間質細胞」の中には, 様々な細胞へと分化する能力を持つ「骨髄間質幹細胞」があることが明らかとなり, 自己組織による再生医療の材料として最近大きな注目を浴びている. 著者らは骨髄間質幹細胞を尾静脈から投与し, 移植した骨髄間質幹細胞が嗅上皮内に生着し神経系細胞へ分化することを確認した.
    The Oto-Rhino-Laryngological Society of Japan, Inc., Feb. 2008, 日本耳鼻咽喉科学会会報, 111巻, 2号, pp. 45-46,np1-np2(2) (2), 45 - 49, Japanese
    Introduction scientific journal

  • 甲状腺癌術後に声帯麻痺がないにもかかわらず発声障害を認めた6例
    齋藤 幹, 常行 美貴, 加藤 智絵里, 後藤田 政子, 丹生 健一
    日本音声言語医学会, Jan. 2008, 音声言語医学, 49(1) (1), 56 - 56, Japanese

  • 当科における過緊張性発声障害について
    常行 美貴, 後藤田 政子, 加藤 智絵里, 斎藤 幹, 丹生 健一
    日本音声言語医学会, Jan. 2008, 音声言語医学, 49(1) (1), 75 - 75, Japanese

  • 喉頭がん患者の看護 喉頭がんの理解
    Nibu Ken-ichi
    メヂカルフレンド社, Oct. 2007, クリニカルスタディ, 28巻, 11号, pp. 55-61(11) (11), 1015 - 1021, Japanese
    Introduction scientific journal

  • 当科における聴器癌例の検討
    長谷川 信吾, 丹生 健一
    22 Sep. 2007, Otology Japan, 17(4) (4), 550 - 550, Japanese

  • Impact of nuclear factor kappa B activity for local tumor controllability by radiotherapy in patients with T1/T2N0 laryngeal cancer
    K. Yoshida, R. Sasaki, Y. Okamoto, Y. Ejima, H. Nishimura, Y. Ota, M. Saitoh, N. Otsuki, K. Nibu, K. Sugimura
    Sep. 2007, EJC SUPPLEMENTS, 5(4) (4), 336 - 337, English
    Summary international conference

  • 下咽頭癌T1、T2症例の治療成績
    大月 直樹, 斎藤 幹, 佐々木 良平, 岡本 欣晃, 丹生 健一
    (一社)日本癌治療学会, Sep. 2007, 日本癌治療学会誌, 42(2) (2), 799 - 799, Japanese

  • 当科における副咽頭間隙腫瘍の臨床的検討
    浦瀬 長昌宏, 平山 裕次, 大月 直樹, 丹生 健一
    10 Aug. 2007, 口腔・咽頭科 = Stomato-pharyngology, 20(1) (1), 126 - 126, Japanese

  • 【医療におけるトラブルをめぐって 予期せぬ出来事への対応】 頭頸部癌領域 重複癌の見落とし
    Nibu Ken-ichi
    Aug. 2007, JOHNS, 23巻, 8号, pp. 1143-1146, Japanese
    Introduction scientific journal

  • 当院におけるI-II期下咽頭癌に対する根治的放射線治療の遡及的検討
    西村 英輝, 佐々木 良平, 岡本 欣晃, 太田 陽介, 吉田 賢史, 杉村 和朗, 丹生 健一, 大月 直樹, 斉藤 幹, 副島 俊典
    (一社)日本頭頸部癌学会, May 2007, 頭頸部癌, 33(2) (2), 124 - 124, Japanese

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    大月 直樹, 齋藤 幹, 谷本 均, 長谷川 信吾, 伊集院 隆宏, 土井 清司, 平山 裕次, 丹生 健一, 佐々木 良平, 岡本 欣晃
    (一社)日本頭頸部癌学会, May 2007, 頭頸部癌, 33(2) (2), 145 - 145, Japanese

  • 手術手技 私が愛用する手術器具 頸部郭清術における手術器具の使い分け
    Nibu Ken-ichi
    May 2007, JOHNS, 23巻, 5号, pp. 806-809, Japanese
    Introduction scientific journal

  • 【ニオイのフォーラム】 嗅上皮の発生・再生
    Nibu Ken-ichi
    May 2007, JOHNS, 23巻, 5号, pp. 693-697, Japanese
    Introduction scientific journal

  • Spasmodic Dysphonia
    SAITO M., WATANABE Y., NIBU K.
    10 Apr. 2007, 日本気管食道科学会会報, 58(2) (2), 166 - 167, Japanese

  • Problems in application of functional MRI for studying taste and smell in humans
    SAKAI Nobuyuki, KOBAYAKAWA Tatsu, OGAWA Hisashi, NIBU Ken-ichi
    The Japanese Association for the Study of Taste and Smell, 01 Apr. 2007, The Japanese journal of taste and smell research, 14(1) (1), 35 - 42, Japanese

  • 【口腔癌にどう対応するか 症例から学ぶ】 舌癌 T4症例の手術治療
    Nibu Ken-ichi
    Apr. 2007, JOHNS, 23巻, 4号, pp. 631-633, Japanese
    Introduction scientific journal

  • Impact of nuclear factor kappa B activity for local tumor controllability by radiotherapy in patients with T1/T2N0 laryngeal cancer
    K. Yoshida, R. Sasaki, Y. Okamoto, H. Nishimura, Y. Ejima, Y. Ota, M. Saitoh, N. Otsuki, K. Nibu, K. Sugimura
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S436 - S436, English
    Summary international conference

  • Radiation therapy for early hypopharyngeal cancer
    H. Nishimura, R. Sasaki, Y. Okamoto, Y. Ota, K. Yoshida, K. Nibu, N. Otsuki, M. Saito, T. Soejima, K. Sugimura
    2007, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 69(3) (3), S447 - S448, English
    Summary international conference

  • 高音域が出にくくなったバンドのボーカリストに対する音声治療の経験
    加藤 智絵里, 斎藤 幹, 後藤田 政子, 丹生 健一
    日本音声言語医学会, Jan. 2007, 音声言語医学, 48(1) (1), 47 - 47, Japanese

  • 【小児科医が知りたい・聞きたい「子どもの耳・鼻・のどQ&A」】 小児頭頸部悪性腫瘍 気をつけたい初発症状
    Nibu Ken-ichi
    日本小児医事出版社, Dec. 2006, 小児科臨床, 59巻, 12号, pp. 2765-2770(12) (12), 2633 - 2638, Japanese
    Introduction scientific journal

  • 【ここまでわかった遺伝子異常】 頭頸部領域 頭頸部扁平上皮癌
    Ohtsuki Naoki, Nibu Ken-ichi
    Dec. 2006, JOHNS, 22巻, 12号, pp. 1769-1774, Japanese
    Introduction scientific journal

  • 【3次元画像の実際】 耳科領域の3次元画像診断 聴器癌
    Nibu Ken-ichi
    Sep. 2006, JOHNS, 22巻, 9号, pp. 1236-1242, Japanese
    Introduction scientific journal

  • Nibu Ken-ichi
    神緑会, Aug. 2006, 神緑会学術誌, 22巻, pp. 60-64, 65 - 65, Japanese
    Introduction scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 食事からみた高齢者の耳鼻咽喉科
    丹生 健一
    20 Apr. 2006, 日本耳鼻咽喉科學會會報, 109(4) (4), 292 - 292, Japanese

  • 鼻副鼻腔腫瘍の拡大手術 鼻副鼻腔悪性腫瘍の拡大手術
    Nibu Ken-ichi
    Apr. 2006, 日本鼻科学会会誌, 45巻, 1号, pp. 102-104(1) (1), 102 - 104, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科・頭頸部外科 症候群事典】 Refsum syndrome
    Nibu Ken-ichi
    Apr. 2006, 耳鼻咽喉科・頭頸部外科, 78巻, 5号, pp. 232-232, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科・頭頸部外科 症候群事典】 Raynaud syndrome
    Nibu Ken-ichi
    Apr. 2006, 耳鼻咽喉科・頭頸部外科, 78巻, 5号, pp. 231-231, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科・頭頸部外科 症候群事典】 Ramsay Hunt syndrome
    Nibu Ken-ichi
    Apr. 2006, 耳鼻咽喉科・頭頸部外科, 78巻, 5号, pp. 230-230, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科救急医療マニュアル】 救急疾患の診断と治療 頭頸部腫瘍と気道確保
    OHTSUKI, Naoki, NIBU, Kenichi
    Mar. 2006, JOHNS, 22巻, 3号, pp.459-462, Japanese
    Introduction scientific journal

  • 香りと臨床医学の最前線 加齢による嗅覚の変化
    Nibu Ken-ichi
    フレグランスジャーナル社, Feb. 2006, Aroma Research, 7巻, 1号, pp. 2-5(1) (1), 12 - 17, Japanese
    Introduction scientific journal

  • THE STANDARDIZATION OF NECK DISSECTION FOR TONGUE CARCINOMA
    ASAKAGE Takahiro, KISHIMOTO Seiji, SAIKAWA Masahisa, HAYASHI Ryuichi, KAWABATA Kazuyoshi, SUGASAWA Masashi, HAYASAKI Katsutake, YOSHIZUMI Takashi, NIBU Ken-ichi, SHIRANE Makoto, NAKATANI Hiroaki
    25 Dec. 2005, 頭頸部癌/ 日本頭頸部癌学会, 31(4) (4), 536 - 540, Japanese

  • NIBU, Kenichi, 田中博紀
    Dec. 2005, 喉頭, 17巻, 2号, pp.89-91(2) (2), 89 - 91, Japanese
    Introduction scientific journal

  • 【全科 術前・術後マニュアル】 代表的手術の術前・術後のポイント 耳鼻咽喉科の手術
    HIRAYAMA, Yuji, NIBU, Kenichi
    照林社, Nov. 2005, Expert Nurse, 21巻, 14号, pp.174-179(14) (14), 9 - 192, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科領域における難治性疾患】 喉頭全摘術後の気管孔再発
    INOUE,Hiroyuki, NIBU, Kenichi
    Sep. 2005, JOHNS, 21巻, 9号, pp.1403-1406, Japanese
    Introduction scientific journal

  • NIBU, Kenichi
    神緑会, Aug. 2005, 神緑会学術誌, 21巻, pp.99-100, 99 - 100, Japanese
    Introduction scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 頚部リンパ節腫脹の鑑別診断
    INOUE,Hiroyuki, NIBU, Kenichi
    Jul. 2005, 耳鼻咽喉科・頭頚部外科, 77巻, 8, pp.541-544, Japanese
    Introduction scientific journal

  • 【頸部リンパ節腫脹】 頸部リンパ節腫脹の鑑別診断
    INOUE,Hiroyuki, NIBU, Kenichi
    Jul. 2005, 耳鼻咽喉科・頭頸部外科, 77巻, 8号, pp.541-544, 563 - 567, Japanese
    Introduction scientific journal

  • 術後機能と後遺症からみた頸部郭清術
    丹生 健一
    15 May 2005, 頭頸部癌/ 日本頭頸部癌学会, 31(2) (2), 164 - 164, Japanese

  • 頭頸部癌術後の咀嚼嚥下のリハビリテーション
    小村 健, 丹生 健一
    15 May 2005, 頭頸部癌/ 日本頭頸部癌学会, 31(2) (2), 181 - 181, Japanese

  • 頸部郭清術の手術術式の均一化に関する研究および頸部郭清術の分類と名称に関する試案について
    斉川 雅久, 岸本 誠司, 中島 格, 長谷川 泰久, 西條 茂, 川端 一嘉, 吉積 隆, 西嶌 渡, 丹生 健一, 甲能 直幸
    15 May 2005, 頭頸部癌/ 日本頭頸部癌学会, 31(2) (2), 162 - 162, Japanese

  • COX-2臓器特異性プロモーターを組み込んだ増殖型アデノウイルスベクターによる頭頸部扁平上皮癌に対する治療法の検討
    田中博紀, NIBU, Kenichi, ZhangZhujun, SHIRAKAWA, Toshiro, 後藤彰暢
    May 2005, 日本耳鼻咽喉科学会会報, 108巻, 5増刊, pp.595-595, Japanese
    Introduction scientific journal

  • 【味覚・嗅覚障害】 嗅覚器の形態と機能
    DOI, Kiyoshi, NIBU, Kenichi
    Mar. 2005, 耳鼻咽喉科・頭頸部外科, 77巻, 3号, pp. 199-205, Japanese
    Introduction scientific journal

  • 【実地医家のための感染症の知識】 症状からみた感染症の診断と治療 口内痛
    平林まり, NIBU, Kenichi
    Feb. 2005, JOHNS, 21巻, 2号, pp. 207-209, Japanese
    Introduction scientific journal

  • 【耳鼻咽喉科・頭頸部外科の癌化学療法レジメン】 臓器特異的なレジメン 上顎癌
    ISHIDA, Haruhiko, NIBU, Kenichi
    Dec. 2004, 耳鼻咽喉科・頭頸部外科, 76巻, 13号, pp. 973-977, Japanese
    Introduction scientific journal

  • 【チャートでみる耳鼻咽喉科治療】 頸部腫脹の治療
    INOUE,Hiroyuki, NIBU, Kenichi
    Oct. 2004, JOHNS, 20巻, 10号, pp. 1594-1597, Japanese
    Introduction scientific journal

  • 鼓膜チューブ留置術を必要とした滲出性中耳炎における中耳貯瘤液と上咽頭粘液の細菌学的検討 : PCR法による
    濱本 由記子, 後藤 友佳子, 香山 智佳子, 中上 佳美, 長谷川 信吾, 下屋 聡子, 丹生 健一
    22 Sep. 2004, Otology Japan, 14(4) (4), 612 - 612, Japanese

  • 【手術範囲と術式】 鼻腔悪性腫瘍
    ISHIDA, Haruhiko, NIBU, Kenichi
    Sep. 2004, JOHNS, 20巻, 9号, pp. 1310-1314, 1391 - 1397, Japanese
    Introduction scientific journal

  • 【悪性リンパ腫 診断・治療マニュアル】 非ホジキンリンパ腫 最近の分類法
    NIBU, Kenichi
    Sep. 2004, ENTONI, 41号, pp. 30-34, Japanese
    Introduction scientific journal

  • 頭頸部癌のクリニカルパス
    斎藤幹, NIBU, Kenichi
    May 2004, ENTONI, 1346-2067巻, 37号, pp. 34-39, Japanese
    Introduction scientific journal

  • においと受容機構 嗅覚器の構造と中枢伝達経路
    市村恵一, 太田康, NIBU, Kenichi, 石川敏夫, 高野澤美奈子, 牧野伸子, 安井理絵, 近藤健二, 松本千織
    Apr. 2004, 日本鼻科学会会誌, 43巻, 1号, pp. 92-94(1) (1), 92 - 94, Japanese
    Introduction scientific journal

  • N Ochi, M Uozumi, K Doi, H Tanimoto, C Ohbayashi, H Inagaki, K Nibu
    2004, ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 66(1) (1), 42 - 45, English

  • NIBU, Kenichi
    Recent advances in neurosurgery and reconstructive surgery have provided the widespread of the skull base surgery using both intracranial approach and extracranial approach, for head and neck tumors involving the skull base. Subtotal temporal bone resection is a surgical technique to eradicate the cancers of the ear with en bloc fashion. At present, subtotal temporal resection is performed in the limited institutions in this country, partly due to the rarity of the cancers involving the temporal bone. In this paper, our surgical technique of subtotal temporal resection is presented. Selection of patients, preparation for surgery, postoperative management, complications are also described.
    Society of Oto-rhino-laryngology Tokyo, Dec. 2003, 耳鼻咽喉科展望, 46巻, 6号, pp. 464-471(6) (6), 464 - 471, Japanese
    Introduction scientific journal

  • NIBU, Kenichi
    Olfactory receptor neurons are located in the olfactory neuroepithelium of the nasal cavity. Olfactory neuroepithelilum has an unusual chararacteristic ability to continue neurogenesis throughout lifetime. This unique character provides an elegant model to study neurogenesis, and fascinates scientists in various fields. This unique ability, also, has made olfactory neuroepithelium as one of the best candidates for "regenerative medicine". This review presents an overview of both physiological and biological data describing the structure and function of olfactory neuroepithelium.
    The Society of Practical Otolaryngology, Oct. 2003, 耳鼻咽喉科臨床, 96巻, 10号, pp. 847-854(10) (10), 847 - 854, Japanese
    Introduction scientific journal

  • 目でみる耳鼻咽喉科 腎性上皮小体機能亢進症の1例
    神野定男, 橋本大, TANIMOTO, Hitoshi, 齋藤幹, OHTSU, Masahide, ISHIDA, Haruhiko, NIBU, Kenichi
    Sep. 2003, 耳鼻咽喉科・頭頸部外科, 75巻, 10号, pp. 678-679, Japanese
    Introduction scientific journal

  • 頭頸部癌の遺伝子治療と遺伝子診断
    丹生健一
    2003, 耳鼻咽喉科 頭頸部外科, 75, 433 - 441

  • 高速度デジタル撮影による気管食道瘻発声の新声門振動の観察
    斎藤 幹, 毛利 光宏, 丹生 健一, 今川 博, 榊原 健一, 和田 満美子, 田山 二朗, 天津 睦郎
    日本音声言語医学会, Jan. 2003, 音声言語医学, 44(1) (1), 87 - 87, Japanese

  • 頸部大血管損傷の予防と対策
    NIBU, Kenichi, SHIMIZU,Kenichiro, OHTSUKI, Naoki
    2003, JOHNS, 19巻, 3, pp. 456-460, Japanese
    Introduction scientific journal

  • 非ホジキンリンパ腫 ─最近の分類法と治療法─
    NIBU, Kenichi
    2003, 日本耳鼻咽喉科学会 専門医通信, 75号, pp. 12-15, Japanese
    Introduction scientific journal

  • 頭頸部癌の遺伝子診断と遺伝子治療
    NIBU, Kenichi, 田中博紀
    2003, 耳鼻咽喉・頭頸部外科, 75巻, 7, pp. 433-441, Japanese
    Introduction scientific journal

  • 加齢による嗅覚の変化
    NIBU, Kenichi
    2003, Aging & Health, 12巻, 2, pp. 16-17, Japanese
    Introduction scientific journal

  • ENDOSCOPIC ENDONASAL PEPAIR OF CSF LEAKS TO THE SINONASAL TRACT
    ISHIDA Haruhiko, TORIYAMA Mayu, KIMURA Mami, INOUE Hiroyuki, NIBU Kenichi
    01 Dec. 2002, 日本鼻科学会会誌, 41(4) (4), 325 - 328, Japanese

  • 滲出性中耳炎における中耳貯瘤液と上咽頭粘液の細菌学的検討ーPCR法による
    濱本 由記子, 後藤 友佳子, 下屋 聡子, 中上 佳美, 丹生 健一, 香山 智佳子
    12 Sep. 2002, Otology Japan, 12(4) (4), 385 - 385, Japanese

  • 中耳真珠腫における外来治療
    毛利 光宏, 高雄 真人, 斎藤 幹, 丹生 健一, 天津 睦郎
    12 Sep. 2002, Otology Japan, 12(4) (4), 377 - 377, Japanese

  • 頸部腫瘤 (特集 小児の耳鼻咽喉科) -- (咽喉頭疾患)
    長谷川 信吾, 丹生 健一
    診断と治療社, Sep. 2002, 小児科診療, 65(9) (9), 1475 - 1480, Japanese

  • Ken-Ichi Nibu
    01 Aug. 2002, Microscopy Research and Technique, 58(3) (3), 133 - 134, English
    Book review

  • 中咽頭側壁型扁平上皮癌症例の検討
    志水 賢一郎, 丹生 健一, 毛利 光宏, 井上 博之, 土井 清司, 副島 俊典, 佐々木 良平, 牧野 邦彦
    (一社)日本頭頸部癌学会, May 2002, 頭頸部腫瘍, 28(2) (2), 447 - 447, Japanese

  • SURGICAL TECHNIQUE OF ANTERIOR SKULL BASE SURGERY FOR TUMORS INVOLVING THE SKULL BASE
    NIBU Ken-ichi, SUGASAWA Masashi, NAKAO Kazunari, MOCHIKI Masato, WATANABE Takeshi, YUGE Tadashi, KAWAHARA Nobutaka, ASATO Hirotaka, TAKUSHIMA Akihiko
    25 Nov. 2001, 頭頚部腫瘍, 27(3) (3), 579 - 583, Japanese

  • 前頭蓋底手術の基本
    丹生 健一
    25 May 2001, 頭頚部腫瘍, 27(2) (2), 280 - 280, Japanese

  • PARTIAL LARYNGECTOMY AS SALVAGE SURGERY AFTER RADIOTHERAPY FAILURE IN T1-T2 GLOTTIC CARCINOMA
    TOMA Makiko, MATSUZAKI Masaki, NAKAO Kazunari, NIBU Ken-ichi, SUZUKI Mitsuya, SUGASAWA Masashi
    25 Mar. 2000, 頭頚部腫瘍, 26(1) (1), 74 - 78, Japanese

  • Multidirectional stabilizing potential of BAK interbody spinal fusion system for anterior surgery - Response
    K Nibu, MM Panjabi, T Oxland, J Cholewicki
    Oct. 1998, JOURNAL OF SPINAL DISORDERS, 11(5) (5), 455 - 455, English
    Report scientific journal

  • Anterior skull base surgery for secondary malignancies in retinoblastoma survivors: Report of two cases
    K Ichimura, K Nibu, T Tanaka, H Takekoshi, T Sasaki, M Taniguchi, T Nakatsuka
    Jan. 1997, SKULL BASE SURGERY, 7(1) (1), 39 - 41, English

  • Nerve paralysis after surgery in the submandibular triangle: Review of University of Tokyo Hospital experience
    K Ichimura, K Nibu, T Tanaka
    Jan. 1997, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 19(1) (1), 48 - 53, English

  • Analysis of Free Flap Reconstruction after Partial Hypopharyngectomy
    KAJIKAWA Akiyoshi, HARII Kiyonori, YAMADA Atsushi, NAKATSUKA Takashi, NIBU Kenichi
    31 Jul. 1995, 日本形成外科学会会誌, 15(7) (7), 498 - 505, Japanese

  • K. Ichimura, K. Nibu, T. Tanaka
    Springer-Verlag, May 1995, European Archives of Oto-Rhino-Laryngology, 252(3) (3), 125 - 129, English
    Book review

  • A CLINICOPATHOLOGICAL STUDY OF THE LESIONS OF VOCAL FOLDS SUSPECTED OF CARCINOMA
    MITMI Natsuhiko, NIBU Kenichi, TAYAMA Nirou, ICHIMURA Keiichi
    30 Mar. 1995, 頭頚部腫瘍, 21(1) (1), 44 - 49, Japanese

  • TREATMENT OF THE DOUBLE CANCER OF HYPOPHARYNGEAL CANCER AND ESOPHAGEAL CANCER
    TETSUKA Katsuhiko, NIBU Kenichi, ICHIMURA Keiichi
    30 Mar. 1995, 頭頚部腫瘍, 21(1) (1), 115 - 119, Japanese

  • リンパ節転移からみた下咽頭癌の予後.
    丹生健一
    1994, JOHNS, 10, 653 - 657

  • 市村恵一, 田山二朗, 丹生健一, 田中利善, 村上泰
    1994, 日本気管食道科学会会報, 45(6) (6), 451 - 455

  • 耳下腺腫瘍42例の臨床統計的観察
    丹生健一
    1991, 耳鼻臨床, 84, 345 - 352

  • CHONDROMYXOID FIBROMA OF THE MASTOID INVADING THE OCCIPITAL BONE
    K KITAMURA, K NIBU, M ASAI, N SHITARA, T NIKI
    Mar. 1989, ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 115(3) (3), 384 - 386, English

■ Books And Other Publications
  • 雑学キング耳・鼻・のど
    宮崎, 総一郎, 高橋, 晴雄(医学), 丹生, 健一
    新興医学出版社, 2019, Japanese, ISBN: 9784880028651

  • 耳鼻咽喉科・頭頸部外科研修ノート
    山岨, 達也, 小川, 郁, 丹生, 健一, 久, 育男, 森山, 寛, 宇佐美, 真一
    診断と治療社, Dec. 2016, Japanese, ISBN: 9784787822390

  • 頭頸部がんの化学放射線療法 : カラーアトラス : 目で見て学ぶ! : 多職種チームで実践する
    丹生, 健一, 佐々木, 良平, 大月, 直樹, 大田, 史江
    日本看護協会出版会, 2015, Japanese, ISBN: 9784818018983

  • JOHNS / 外側側頭骨切除術、側頭骨亜全摘出術
    Hasegawa Shingo, Nibu Ken-ichi
    Others, 東京医学社, Apr. 2013, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頚部外科研修ノート
    山岨, 達也, 小川, 郁, 鈴木, 衛, 丹生, 健一, 久, 育男, 森山, 寛
    診断と治療社, 2011, Japanese, ISBN: 9784787818270

  • 耳科領域編
    小林, 俊光, 小宗, 静男, 丹生, 健一, 加我, 君孝
    国際医学出版, 2011, Japanese, ISBN: 9784861021763

  • 鼻 口腔・咽頭 喉頭編
    小林, 俊光, 小宗, 静男, 丹生, 健一, 加我, 君孝
    国際医学出版, 2011, Japanese, ISBN: 9784861021855

  • 目で見て学ぶ放射線療法の有害反応 : 多職種チームで実践する治療と患者支援 : カラーアトラス
    丹生, 健一, 佐々木, 良平, 鈴木, 志津枝
    日本看護協会出版会, 2011, Japanese, ISBN: 9784818015944

  • 頭頸部悪性腫瘍の初期症状とその対応
    丹生, 健一
    全日本病院出版会, 2011, Japanese, ISBN: 9784881178171

  • 症例からみる難治性疾患の診断と治療 耳科領域編 / 第8章 聴器癌
    Nibu Ken-ichi, Hasegawa Shingo, Kohmura Eiji
    Others, 国際医学出版, 2011, Japanese
    Scholarly book

  • ENTONI / 耳鼻咽喉科と結核 上咽頭結核
    Hasegawa Shingo, Nibu Ken-ichi
    Others, 全日本病院出版社, 2011, Japanese
    Scholarly book

  • JOHNS / 聴器癌に対する治療法の選択は？－手術治療の立場から－
    Hasegawa Shingo, Nibu Ken-ichi
    Others, 東京医学社, Oct. 2009, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頸部外科 / 外耳道全摘出術
    Hasegawa Shingo, Nibu Ken-ichi
    Others, 医学書院, 2009, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頚部外科学の最新医療
    加我, 君孝, 小宗, 静男, 山岨, 達也, 市村, 恵一, 原渕, 保明, 久, 育男, 丹生, 健一
    寺田国際事務所/先端医療技術研究所, 2005, Japanese, ISBN: 4925089439

  • 耳鼻咽喉科・頭頸部外科学の最新医療 / 喉頭全摘出術と音声再建
    Nibu Ken-ichi
    Joint work, 先端医療技術研究所, 2005, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頸部外科の最新医療 / 嗅神経細胞の発生と再生
    Nibu Ken-ichi
    Joint work, 先端医療技術研究所, 2005, Japanese
    Scholarly book

  • イラスト手術手技のコツ 耳鼻咽喉科頭頸部外科―咽喉頭頸部編 / 喉頭全摘出術―気管食道瘻形成術の留意点
    Nibu Ken-ichi
    Joint work, 東京医学社, 2005, Japanese
    Scholarly book

  • イラスト手術手技のコツ 耳鼻咽喉科頭頸部外科―咽喉頭頸部編 / 口蓋多形腺腫の手術―腫瘍切除と口蓋欠損部への対応
    Nibu Ken-ichi
    Joint work, 東京医学社, 2005, Japanese
    Scholarly book

  • 新耳鼻咽喉科学 / 頭頸科学
    Nibu Ken-ichi
    Joint work, 南山堂, 2004, Japanese
    Textbook

  • 耳鼻咽喉科診療Q＆A / 嗅覚閾値の解離現象の意義について
    Nibu Ken-ichi
    Joint work, 六法, 2004, Japanese
    Scholarly book

  • 耳鼻咽喉科診療Q＆A / 副嗅覚系について
    Nibu Ken-ichi
    Joint work, 六法出版社, 2004, Japanese
    Scholarly book

  • 耳鼻咽喉科・頭頸部外科クリニカルトレンドPart4 / 新しいTNM分類法（2002年改訂）
    Nibu Ken-ichi
    Joint work, 中山書店, 2004, Japanese
    Scholarly book

  • 耳鼻咽喉科 / 頸部郭清術の新分類
    Nibu Ken-ichi
    Joint work, 中山書店, 2004, Japanese
    Scholarly book

  • イラスト手術手技のコツ 耳鼻咽喉科・頭頸部外科 耳・鼻編 / 嗅神経芽細胞腫ｎ手術ー経頭蓋内アプローチ、頭蓋底の切除
    NIBU, Kenichi, ISHIDA, Haruhiko
    Joint work, 東京医学社, Nov. 2003, Japanese
    Scholarly book

  • 耳鼻咽喉科薬物療法マニュアル / 耳鼻咽喉科疾患に対する私の薬物療法ー悪性腫瘍ー悪性黒色腫
    Ishida Haruhiko, Nibu Ken-ichi
    Joint work, 金原出版, May 2003, Japanese
    Scholarly book

  • 今日の耳鼻咽喉科頭頸部外科治療指針 / 外耳道癌
    Nibu Ken-ichi
    Joint work, 医学書院, May 2003, Japanese
    Scholarly book

  • イラスト手術手技のコツ 耳鼻咽喉科頭頸部外科―耳・鼻編 / 嗅神経芽細胞腫の手術
    Nibu Ken-ichi
    Joint work, 医学書院, 2003, Japanese
    Scholarly book

  • EBM耳鼻咽喉科・頭頸部外科の治療
    池田, 勝久, 武田, 憲昭, 井之口, 昭, 原渕, 保明, 丹生, 健一, 香取, 幸夫
    中外医学社, Japanese, ISBN: 9784498062528

  • 症例から見る難治性疾患の診断と治療
    加我, 君孝, 小林, 俊光, 小宗, 静男, 丹生, 健一
    国際医学出版, Japanese

■ Lectures, oral presentations, etc.
  • 当科における内視鏡下輪状咽頭筋切断術の経験
    FURUKAWA TATSUYA, MORIMOTO KOICHI, 藤尾 久美, 小松 弘和, 茂木 千聡, 由井 光子, 下田 光, SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI, 岩城 忍, 高橋 美貴, 涌井 絵美, 上岡 美和
    第42回日本嚥下医学会, Mar. 2019, Japanese, 久留米, Domestic conference
    Oral presentation

  • 当科における声帯麻痺症例の検討
    SHINOMIYA HIROTAKA, 岩城 忍, 高橋 美貴, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI
    第31回喉頭科学会, Mar. 2019, Japanese, 久留米, Domestic conference
    Oral presentation

  • 頭頸部HPV陽性扁平上皮癌マウスモデルにおける放射線分割照射と抗PD-1抗体併用療法の効果
    INOKUCHI GOU, NIBU KENICHI
    第37回日本耳鼻咽喉科免疫アレルギー学会, Feb. 2019, Japanese, 大阪, Domestic conference
    Invited oral presentation

  • 施行しHRMで評価した1例
    FURUKAWA TATSUYA, TESHIMA MASANORI, UEHARA NATSUMI, 森本 浩一, 藤尾 久美, 小松 弘和, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI
    第29回 日本頭頸部外科学会, Jan. 2019, Japanese, 仙台, Domestic conference
    Oral presentation

  • 外耳道癌術後の嚥下障害に段階的に嚥下機能改善手術を
    FURUKAWA TATSUYA, TESHIMA MASANORI, UEHARA NATSUMI, 森本 浩一, 藤尾 久美, 小松 弘和, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI
    第29回 日本頭頸部外科学会, Jan. 2019, Japanese, 仙台, Domestic conference
    Oral presentation

  • 片側反回神経麻痺を伴う甲状腺乳頭癌症例の検討
    TESHIMA MASANORI, OTSUKI NAOKI, MORITA NARUHIKO, FURUKAWA TATSUYA, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, NIBU KENICHI
    日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 片側反回神経麻痺を伴う甲状腺乳頭癌症例の検討
    TESHIMA MASANORI, OTSUKI NAOKI, MORITA NARUHIKO, FURUKAWA TATSUYA, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, NIBU KENICHI
    第５１回日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 成人症例における難聴遺伝子解析の検討
    UEHARA NATSUMI, FUJITA TAKESHI, 勝沼 紗矢香, KAKIGI AKINOBU, NIBU KENICHI
    日本人類遺伝学会第63回大会, Oct. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 神経筋疾患に対する声門閉鎖術実施における周術期の問題点
    FURUKAWA TATSUYA, 小松 弘和, 藤尾 久美, 茂木 千聡, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI
    第1４回 日本神経筋疾患摂食・嚥下・栄養研究会, Oct. 2018, Japanese, 名古屋, Domestic conference
    Oral presentation

  • 甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討
    金原 史朗, KIYOTA NAOMI, 今村 善宣, OTSUKI NAOKI, NIBU KENICHI, MINAMIKAWA TSUTOMU, 原 仁美, 角谷 賢一朗, SASAKI RYOHEI, MINAMI HIRONOBU
    日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 喉頭全摘後のシャント発声の音声評価
    SHINOMIYA HIROTAKA, 岩城 忍, 高橋 美貴, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI
    第63回音声言語医学会, Oct. 2018, Japanese, 久留米, Domestic conference
    Oral presentation

  • 偶発型甲状腺未分化癌４例の検討
    MORITA NARUHIKO, TESHIMA MASANORI, OTSUKI NAOKI, NIBU KENICHI
    第51回日本甲状腺外科学会学術集会, Oct. 2018, Japanese, 横浜, Domestic conference
    Poster presentation

  • 偶発型甲状腺未分化癌4例の検討
    MORITA NARUHIKO, TESHIMA MASANORI, OTSUKI NAOKI, NIBU KENICHI
    日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference
    Poster presentation

  • 急速に進行し半規管瘻孔をきたした小児後天性真珠腫症例のCT値による検討
    UEHARA NATSUMI, KAKIGI AKINOBU, NIBU KENICHI
    第28回日本耳科学会総会・学術講演会, Oct. 2018, Japanese, 大阪, Domestic conference
    Poster presentation

  • Cochlear Function in New Animal Model of Meniere’s Disease
    Akinobu Kakigi, Naoya Egami, Takuma Shirahata, Shinji Yamashita, Kenichi Nibu, Tatsuya Yamasoba
    AAO-HNSF Annual Meeting & OTO Experience2018, Oct. 2018, English, Atlanta, International conference
    Public symposium

  • 常在細菌による成体マウス脳室下帯におけるニュートロン新生の制御
    澤田 直樹, KOTANI TAKENORI, 金野 祐, ジャジャル セティアワン, SAITO YASUYUKI, MURATA YOJI, NIBU KENICHI, MATOZAKI TAKASHI
    第91回日本生化学会大会, Sep. 2018, English, 日本生化学会, 京都, Domestic conference
    Poster presentation

  • バセドウ病眼症減圧手術に関連する難治性副鼻腔炎に対し、内視鏡下副鼻腔手術を行った3例の検討
    蓼原 瞬, INOKUCHI GOU, 古閑 紀雄, FUJIO HISAMI, NIBU KENICHI
    第57回日本鼻科学会総会・学術講演会, Sep. 2018, Japanese, 旭川, Domestic conference
    Oral presentation

  • 当科における内視鏡下輪状咽頭筋切断術の経験
    FURUKAWA TATSUYA, MORIMOTO KOICHI, 小松 弘和, FUJIO HISAMI, 茂木 千聡, UEHARA NATSUMI, SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI, 岩城 忍, 高橋 美貴, 上岡 美和, 千年 俊一
    第189回日耳鼻兵庫県地方部会, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 当院における聴器癌に対する側頭骨亜全摘術の手術手技と治療成績-脳神経外科からの視点 –
    KIMURA HIDEHITO, TANIGUCHI MASAAKI, SHINOMIYA HIROTAKA, TESHIMA MASANORI, NIBU KENICHI, KOHMURA EIJI
    第30回日本頭蓋底外科学会, Jul. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 成人症例における難聴遺伝子解析の検討
    UEHARA NATSUMI, FUJITA TAKESHI, 勝沼 紗矢香, KAKIGI AKINOBU, NIBU KENICHI
    第189回日耳鼻兵庫県地方部会学術講演, Jul. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 教育パネル 頭蓋底外科医の育成
    NIBU KENICHI
    第30回日本頭蓋底外科学会, Jul. 2018, Japanese, 東京, Domestic conference
    Public symposium

  • Overexpression of SOCS3 mediated by adenovirus vector in prostate cancer cells increased the sensitivity to lymphokine-activated killer cells in vitro and in vivo.
    KITAGAWA KOICHI, 米田 智美, 石河 求己, 門脇 雅英, OTSUKI NAOKI, NIBU KENICHI, FUJISAWA MASATO, 世良田 聡, 仲 哲治, SHIRAKAWA TOSHIRO
    第24回日本遺伝子細胞治療学会, Jul. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 頭頸部腺様嚢胞癌63例の臨床病理学的検討
    池田 千浦子, MORITA NARUHIKO, OTSUKI NAOKI, 西尾 真理, 狛 雄一朗, NIBU KENICHI, 伊藤 智雄, 横崎 宏
    日本病理学会, Jun. 2018, Japanese, 札幌, Domestic conference
    Oral presentation

  • 頭頸部腺様嚢胞癌63例の臨床病理学的検討
    池田 千浦子, 森田 成彦, OTSUKI NAOKI, NISHIO MARI, KOMA YUICHIRO, NIBU KENICHI, ITO TOMOO, YOKOZAKI HIROSHI
    第107回日本病理学会総会, Jun. 2018, Japanese, 日本病理学会, 札幌市, Domestic conference
    Poster presentation

  • 頭頸部癌治療後の嚥下障害に対して施行した声門閉鎖術
    FURUKAWA TATSUYA, 小松 弘和, 藤尾 久美, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORITA NARUHIKO, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 頭頸部癌治療後の嚥下障害に対して
    FURUKAWA TATSUYA, 小松 弘和, FUJIO HISAMI, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI
    第42回日本頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Poster presentation

  • 頭蓋底進展眼窩悪性腫瘍の臨床的検討
    TESHIMA MASANORI, 堀地 祐人, SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 当科における頭蓋底進展眼窩悪性腫瘍の検討
    TESHIMA MASANORI, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KIMURA HIDEHITO, TANIGUCHI MASAAKI, HASHIKAWA KAZUNOBU, KOHMURA EIJI, NIBU KENICHI
    第３０回日本頭蓋底外科学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 当科における頭蓋底進展眼窩悪性腫瘍の検討
    TESHIMA MASANORI, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KIMURA HIDEHITO, TANIGUCHI MASAAKI, HASHIKAWA KAZUNOBU, KOHMURA EIJI, NIBU KENICHI
    第４２回日本頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 椿の枝で受傷した外傷性外リンパ瘻の1例
    UEHARA NATSUMI, KAKIGI AKINOBU, NIBU KENICHI
    第80回耳鼻咽喉科臨床学会総会・学術講演会, Jun. 2018, Japanese, 横浜, Domestic conference
    Oral presentation

  • 聴器原発悪性腫瘍の予後因子に関する検討
    SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI
    第42回頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 聴器原発悪性腫瘍の予後因子に関する検討
    SHINOMIYA HIROTAKA, TESHIMA MASANORI, OTSUKI NAOKI, 柿木 章伸, NIBU KENICHI
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 声門閉鎖術を施行した6例
    FURUKAWA TATSUYA, 小松 弘和, FUJIO HISAMI, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI
    第42回日本頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Poster presentation

  • 再発・転移の頭頸部非扁平上皮癌に対するドセタキセル+シスプラチン併用療法の第II相臨床試録
    今村 善宣, KIYOTA NAOMI, 田中 薫, 林 秀俊, 太田 一郎, 平野 滋, 岩江 信法, 南 修司郎, 家根 且有, 山崎 知子, 長谷 善明, 豊田 昌徳, OTSUKI NAOKI, NIBU KENICHI, MINAMI HIRONOBU
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 甲状腺癌気道浸潤例に対する放射線外照射の有効性の検討
    鈴木 千晶, KIYOTA NAOMI, OTSUKI NAOKI, 宮脇 大輔, 今村 善宣, NIBU KENICHI, SASAKI RYOHEI
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 口腔癌cN1症例に関する頸部郭清術の郭清範囲についての検討
    筧 康正, 南川 勉, 小松 弘和, OTSUKI NAOKI, NIBU KENICHI, 古森 孝英
    頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 口腔底癌心臓転移の一例
    FUJIO HISAMI, OTSUKI NAOKI, 堀地 祐人, TESHIMA MASANORI, SHINOMIYA HIROTAKA, NIBU KENICHI
    日本耳鼻咽喉科学会, May 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • シンポジウム AMED研究：頭頸部領域 頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    NIBU KENICHI
    第120回日本耳鼻咽喉科学会総会・学術講演会, May 2018, Japanese, 横浜, Domestic conference
    [Invited]
    Nominated symposium

  • オープンエッセンス法による感冒後嗅覚障害の検討
    黒木 俊介, FUJIO HISAMI, 蓼原 瞬, INOKUCHI GOU, NIBU KENICHI
    第119回日本耳鼻咽喉科学会総会・学術講演会, May 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • TRAUMATIC PERILYMPHATIC FISTULA CAUSED BY A CAMELLIA BRANCH
    Natsumi UEHARA, Akinobu KAKIGI, Kenichi NIBU
    the 6th East Asian Symposium on Otology, May 2018, English, ソウル, International conference
    Oral presentation

  • 当科における声門閉鎖術
    小松 弘和, Fujio Kumi, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi
    第30回日本喉頭科学会, Mar. 2018, Japanese, 日本喉頭科学会, 高知, Domestic conference
    Poster presentation

  • 当院における食道癌術後摂食嚥下障害の検討
    小松 弘和, Fujio Kumi, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi
    第41回日本嚥下医学会, Feb. 2018, Japanese, 日本嚥下医学会, 仙台, Domestic conference
    Oral presentation

  • Exploratory analysis of prognostic and predictive factors of lenvatinib for radioiodine-refractory differentiated thyroid cancer
    Chiaki Suzuki, Kiyota Naomi, Yoshinori Imamura, Yoshiaki Nagatani, Hirotaka Suto, Naoko Chayahara, Toyoda Masanori, Yasuhiro Ito, Akihiro Miya, Akira Miyauchi, Naoki Otsuki, Nibu Ken-ichi, Minami Hironobu
    The 2018 Multidisciplinary Head and Neck Cancers Symposium, Feb. 2018, English, ASTRO, Arizona, USA, International conference
    Poster presentation

  • 進行下咽頭癌手術例における外側咽頭後リンパ節郭清の意義について
    Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi
    第28回日本頭頸部外科学会, Jan. 2018, Japanese, 日本頭頸部外科学会, 宇都宮, Domestic conference
    Oral presentation

  • 難聴を契機に診断されたCat Eye症候群の1例
    Uehara Natsumi, Ikeda Mariko, Kakigi Akinobu, Iijima Kazumoto, Toda Tatsushi, Nibu Ken-ichi
    日本人類遺伝学会 第62回大会, Nov. 2017, Japanese, 日本人類遺伝学会, 神戸, Domestic conference
    Poster presentation

  • Surgical approaches for thyroid cancer extending to the mediastinum
    Naruhiko Morita, Furukawa Tatsuya, Masanori Teshima, Naoki Otsuki, Nibu Ken-ichi
    2nd Congress of Asia-Pacific Society of Thyroid Surgery, Nov. 2017, English, 2nd Congress of Asia-Pacific Society of Thyroid Surgery, 沖縄, International conference
    Poster presentation

  • Parathyroid function after total thyroidectomy for thyroid carcinoma
    Masanori Teshima, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Shinomiya Hirotaka, Naoki Otsuki, Nibu Ken-ichi
    2nd Congress of Asia-Pacific Society of Thyroid Surgery, Nov. 2017, English, Asia-Pacific Society of Thyroid Surgery, 那覇, International conference
    Oral presentation

  • Detection and preservation of parathyroid glands in total thyroidectoy for thyroid cancer
    Naoki Otsuki, Masanori Teshima, Tatsuya Furukawa, Naruhiko Morita, Nibu Ken-ichi
    2th Congress of Asia-Pacific thyroid Surgery, Nov. 2017, English, Society of Asia-Pacific thyroid Surgery, Naha, Japan, International conference
    [Invited]
    Nominated symposium

  • A case of left non-recurrent inferior laryngeal nerve with right-sided aortic arch
    Tatsuya Furukawa, Naoki Otsuki, Msahiro Tomotsu, Naruhiko Morita, Masanori Teshima, Shinomiya Hirotaka, Nibu Ken-ichi
    2nd Congress of Asia-Pacific Society of Thyroid Surgery, Nov. 2017, English, 2nd Congress of Asia-Pacific Society of Thyroid Surgery, Okinawa, Japan, International conference
    Oral presentation

  • 臓器別シンポジウム6 「それぞれの癌」頭頸部癌
    Nibu Ken-ichi
    第55回日本癌治療学会総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, 頭頸部癌の診断と治療の現場と展望を解説する, Domestic conference
    [Invited]
    Nominated symposium

  • 甲状腺癌の縦隔進展例に対する アプローチの検討
    Ohtsuki Naoki, Nibu Ken-ichi
    第50回日本甲状腺外科学会学術集会, Oct. 2017, Japanese, 日本甲状腺外科学会, 福島, Domestic conference
    Poster presentation

  • シンポジウム 進化するがん診療ガイドライン
    Nibu Ken-ichi
    第55回日本癌治療学会総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, 最新の頭頸部がん診療ガイドラインを解説する, Domestic conference
    [Invited]
    Nominated symposium

  • Treatent of Ear and Maxillzry Cancers
    Nibu Ken-ichi
    4th Conference of Europian Congress of Otolaryngology-Head and Neck Surgery, Oct. 2017, English, Europian Congress of Otolaryngology-Head and Neck Surgery, Barcelona, Treatent of Ear and Maxillzry Cancers, International conference
    Public discourse

  • 術後に両側声帯麻痺を来した症例
    Ohtsuki Naoki, Nibu Ken-ichi
    第7回関西頭頸部腫瘍懇話会, Sep. 2017, Japanese, 関西頭頸部腫瘍懇話会, 大阪, Domestic conference
    Oral presentation

  • 当科における声門閉鎖術
    小松 弘和, Fujio Kumi, 鶴田 賀之, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi
    日耳鼻地方部会, Jul. 2017, Japanese, 神戸, Domestic conference
    Oral presentation

  • 上咽頭癌に対する強度変調放射線治療を用いた放射線療法の初期経験
    Miyawaki Daisuke, Ishihara Takeaki, Uezono Haruka, Yoshida Kenji, 清田 直臣, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第30回学術大会, Jul. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conference
    Poster presentation

  • 当科における 頭頸部腺様嚢胞癌の検討
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    第41回日本頭頸部癌学会, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conference
    Oral presentation

  • 当院における 嗅神経芽細胞腫の検討
    Ohtsuki Naoki, Shinomiya Hirotaka, Inokuchi Gou, Kokan Norio, Kiyota Naomi, Sasaki Ryohei, Kohmura Eiji, Nibu Ken-ichi
    第41回日本頭頸部癌学会, Jun. 2017, Japanese, 京都, Domestic conference
    Oral presentation

  • 学術セミナー7 高齢者に対するがん治療
    Nibu Ken-ichi
    第118回日本耳鼻咽喉科学会総会, May 2017, Japanese, 日本耳鼻咽喉科学会, 広島, 高齢者の頭頸部癌に対する治療戦略, Domestic conference
    Public discourse

  • オープンエッセンス（OE）を用いた嗅覚の加齢性変化の検討
    Fujio Kumi, 黒木俊介, 福田有里子, Inokuchi Gou, Kokan Norio, Nibu Ken-ichi
    Nippon Jibiinnkouka Gakkai, May 2017, Japanese, 日本耳鼻咽喉科学会会報, 広島, Domestic conference
    Oral presentation

  • 診断に苦慮した 喉頭アレルギーの1例
    Morimoto Koichi, Shinomiya Hirotaka, 齋藤 幹, Ohtsuki Naoki, Nibu Ken-ichi
    第29回日本喉頭科学会, Apr. 2017, Japanese, 日本喉頭科学会, 盛岡, Domestic conference
    Oral presentation

  • 多発血管炎性肉芽腫症により眼窩先端症候群をきたした一例
    鶴田 賀之, Fujio Kumi, 福田 有里子, Kokan Norio, Inokuchi Gou, Ohtsuki Naoki, 市川 晋也, Akashi Kengo, 高橋 祐一, Hara Shigeo, Nibu Ken-ichi
    第185回日耳鼻兵庫県地方部会学術講演会, Mar. 2017, Japanese, 日本耳鼻咽喉科学会兵庫県地方部会, 姫路, Domestic conference
    Oral presentation

  • 右大動脈弓に伴う左非反回下喉頭神経の1例
    鞆津 匡宏, 古川 竜也, 森田 成彦, Ohtsuki Naoki, Nibu Ken-ichi
    第185回日耳鼻兵庫県地方部会学術講演会, Mar. 2017, Japanese, 日本耳鼻咽喉科学会兵庫県地方部会, 兵庫県, Domestic conference
    Oral presentation

  • Treatment outcome of transoral Resection against Hypopharyngeal Cancers
    Morimoto Koichi, Shinomiya Hirotaka, 古川 竜也, Nibu Ken-ichi
    5th Congress of Asian Society of Head and Neck Oncology, Mar. 2017, English, Congress of Asian Society of Head and Neck Oncology, Bali, インドネシア, International conference
    Public symposium

  • Superselective intra-arterial infusion of high-dose cisplatin with radiotherapy (RADPLAT) for patients with locally advanced maxillary sinus carcinomas
    Ryoko Miyazaki, Shinomiya Hirotaka, Nibu Ken-ichi
    5th congress of Asian Sosiety of Head and Neck oncology, Mar. 2017, English, ASHNO congress, Bali, Indonesia, International conference
    Public symposium

  • Safety laryngeal closure after treatment of head and neck cancer
    Tatsuya Furukawa, Hirokazu Komatsu, Hisami Fujio, Shinomiya Hirotaka, Naoki Otsuki, Nibu Ken-ichi
    5th congress of Asian Society of Head and Neck Oncology, Mar. 2017, English, Asian Society of Head and Neck Oncology, bali, インドネシア, International conference
    Public symposium

  • RADPLAT for advanced maxillary Ca
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    5th congress of asia head and neck oncology, Mar. 2017, English, Asian society of head and neck oncology, バリ, インドネシア, International conference
    [Invited]
    Nominated symposium

  • Patterns of neck metastases in surgically treated parotid cancer
    Naoki Otsuki, Hitomi Shinomiya, Tatsuya Furukawa, Naruhiko Morita, Nibu Ken-ichi
    ５th Congress of Asian Society of Head and Neck Oncology (ASHNO), Mar. 2017, English, Asian Society of Head and Neck Oncology (ASHNO), Bali, Indonesia, International conference
    Oral presentation

  • Patterns of neck metastases in surgically treated parotid cancer
    Ohtsuki Naoki, Shinomiya Hitomi, 古川竜也, 森田成彦, Nibu Ken-ichi
    5th Congress of Asian society of head and neck oncology, Mar. 2017, English, Asian society of head and neck oncology, Bali, Indonesia, International conference
    Oral presentation

  • complihensive management of temporal bone malignancies
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    5th congress of asia head and neck oncology, Mar. 2017, English, Asian society of head and neck oncology, バリ, インドネシア, International conference
    [Invited]
    Nominated symposium

  • 頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    Nibu Ken-ichi
    AMED公開シンポジウム頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出, Feb. 2017, Japanese, 日本頭頸部癌学会, 東京, 頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出, Domestic conference
    Public discourse

  • 当科における頭蓋底進展眼窩悪性腫瘍の臨床的検討
    堀地祐人, Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    第27回日本頭頸部外科学会総会ならびに学術講演会, Feb. 2017, Japanese, JAPAN SOCIETY FOR HEAD AND NECK SURGERY, 東京, Domestic conference
    Oral presentation

  • 多発血管炎性肉芽腫症により眼窩先端症候群をきたした一例
    鶴田 賀之, Fujio Kumi, 福田 有里子, Kokan Norio, Inokuchi Gou, Ohtsuki Naoki, Nibu Ken-ichi
    第27回日本頭頸部外科学会総会, Feb. 2017, Japanese, 日本頭頸部外科学会, 東京, Domestic conference
    Oral presentation

  • シンポジウム2 希少難治疾患の手術対応 頸動脈小体腫瘍
    Nibu Ken-ichi
    第27回日本頭頸部外科学会総会, Feb. 2017, Japanese, 日本頭頸部外科学会, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • 粘表皮癌におけるCRTC1/3-MAML2キメラ遺伝子とAmphiregulinの発現について
    Shinomiya Hitomi, 伊藤 洋平, 久保 美恵, Ohtsuki Naoki, Nibu Ken-ichi, 稲垣 宏
    第61回日本唾液腺学会, Dec. 2016, Japanese, 日本唾液腺学会, 東京, Domestic conference
    Oral presentation

  • 早期声門癌に対する経口的CO2レーザー切除術の治療成績
    Morimoto Koichi, Shinomiya Hirotaka, Nibu Ken-ichi
    第9回喉頭機能温存治療研究会, Nov. 2016, Japanese, 喉頭機能温存研究会, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • Outcomes after radiation therapy for recurrent carcinoma of the oral tongue
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Minamikawa Tsutomu, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 29th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2016, Japanese, Japanese Society for Radiation Oncology, 京都, Domestic conference
    Oral presentation

  • 嗅上皮の細胞の並び方を形成するネクチンとカドヘリンの協調的な働き
    Katsunuma Sayaka, Nibu Ken-ichi
    第55回 日本鼻科学会総会・学術講演会, Oct. 2016, Japanese, 日本鼻科学会, 宇都宮市, Domestic conference
    Poster presentation

  • 副甲状腺線種からの出血により深頸部縦隔血腫をきたした1例
    本郷 裕斗, Kouno Kenji, Ohtsuki Naoki, Okada Takuya, Fujii Hideki, 森田 成彦, Nibu Ken-ichi, Nishi Shinichi
    第46回 日本腎臓学会西部学術大会, Oct. 2016, Japanese, 日本腎臓学会, Ｍｉｙａｚａｋｉ, 宮崎, Domestic conference
    Oral presentation

  • 内頸静脈に腫瘍塞栓を形成した甲状腺濾胞癌の2例
    森田 成彦, Shinomiya Hitomi, Ohtsuki Naoki, Nibu Ken-ichi
    第49回日本甲状腺外科学会学術集会, Oct. 2016, Japanese, 日本甲状腺外科学会, 甲府, Domestic conference
    Poster presentation

  • 当科における難聴遺伝子解析の検討
    Uehara Natsumi, 山下 大介, 堀地 祐人, Katsunuma Sayaka, Kakigi Akinobu, Nibu Ken-ichi, 西尾 信哉, 宇佐美 真一
    第26回日本耳科学会総会・学術講演会, Oct. 2016, Japanese, 日本耳科学会, 長野市, Domestic conference
    Poster presentation

  • 当科におけるシャント発声の現状と課題
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    第9回喉頭機能温存治療研究会, Oct. 2016, Japanese, 喉頭機能温存研究会, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • 上顎洞血瘤腫に対する術式の検討
    Kokan Norio, Inokuchi Gou, Fujio Kumi, 髙原慎一, 福田有里子, Nibu Ken-ichi
    The 55th Annual Meeting of the Japanese Rhinologic Society, Oct. 2016, Japanese, The Japanese Rhinologic Society, 栃木, Domestic conference
    Oral presentation

  • 遺伝性出血性毛細血管拡張症関連鼻出血に対するエストリオール軟膏の治療効果
    福田有里子, 髙原慎一, Inokuchi Gou, 黒木俊介, Kokan Norio, Fujio Kumi, Nibu Ken-ichi
    第55回日本鼻科学会総会, Oct. 2016, Japanese, 日本鼻科学会, 栃木, Domestic conference
    Oral presentation

  • パーキンソン病（PD)と高齢者ボランティアにおける嗅覚障害の検討
    Fujio Kumi, Inokuchi Gou, 黒木 俊介, 福田 有里子, Nibu Ken-ichi
    第55回 日本鼻科学会総会・学術講演会, Oct. 2016, Japanese, 日本鼻科学会, 宇都宮, Domestic conference
    Oral presentation

  • Organ Preservation Surgery for Hypopharyngeal Cancer
    Nibu Ken-ichi
    AAOHNS annual meeting, Sep. 2016, English, AAOHNS, San Diego, USA, Organ Preservation Surgery for Hypopharyngeal Cancer, International conference
    Public symposium

  • Skull Base "Anterior and Lateral"
    Nibu Ken-ichi
    National Congress of Indonesian Society of Otolaryngology-Head and Neck Surgery, Aug. 2016, English, Indonesian Society of Otolaryngology-Head and Neck Surgery, Solo, Indonesia, Skull Base "Anterior and Lateral", International conference
    [Invited]
    Nominated symposium

  • How I Do Itlaryngectomy & Reconstruction
    Nibu Ken-ichi
    National Congress of Indonesian Society of Otolaryngology-Head and Neck Surgery, Aug. 2016, English, Indonesian Society of Otolaryngology-Head and Neck Surgery, Solo, Indonesia, How I Do Itlaryngectomy & Reconstruction, International conference
    [Invited]
    Nominated symposium

  • Expression of Amphiregulin in Mucoepidermoid Carcinoma
    Shinomiya Hitomi, Ito Y, Kubo M, Ohtsuki Naoki, Inagaki H, Nibu Ken-ichi
    CORALS, Aug. 2016, English, CORALS, Bordeux, France, Expression of Amphiregulin in Mucoepidermoid Carcinoma, International conference
    Poster presentation

  • シスプラチン投与患者におけるeGFR / CKD-EPIの検討
    船越 洋平, 藤原 豊, Kiyota Naomi, Mukohara Toru, Toyoda Masanori, 今村 善宣, 茶屋原 菜穂子, 梅津 道夫, Nibu Ken-ichi, Minami Hironobu
    第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conference
    Oral presentation

  • Thyroid Nodule Molecular Testing Assays and Decison Making
    Nibu Ken-ichi
    AHNS9th International Conference on Head and Neck Cancer, Jul. 2016, English, AHNS, Seatle, USA, Thyroid Nodule Molecular Testing Assays and Decison Making, International conference
    [Invited]
    Nominated symposium

  • First-Line Chemotherapy for Recurrent or Metastatic Head and Neck Cancer with or without Cetuximab: A single institution experience
    今村 善宣, Kiyota Naomi, Toyoda Masanori, 茶屋原 菜穂子, 後藤 秀彰, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第14回日本臨床腫瘍学会, Jul. 2016, English, 日本臨床腫瘍学会, 兵庫, Domestic conference
    Poster presentation

  • Current Management of Oral Cavity Cancer
    Nibu Ken-ichi
    AHNS9th International Conference on Head and Neck Cancer, Jul. 2016, English, AHNS, Seatle, USA, Current Management of Oral Cavity Cancer, International conference
    [Invited]
    Nominated symposium

  • Amphiregulin in mucoepidermoid carcinoma of the major salivary gland
    Shinomiya Hitomi, 伊藤 洋平, 久保 美恵, Ohtsuki Naoki, 稲垣 宏, Nibu Ken-ichi
    9th International conference on head and neck cancer, Jul. 2016, English, AHNS, Seattle, US, International conference
    Poster presentation

  • 鼻腔腫瘍に対する放射線治療の経験
    西川 遼, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, 井上 由子, 松尾 圭朗, ノル シャズリナ, Ejima Yasuo, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 粘表皮癌におけるCRTC1-MAML2キメラ遺伝子とアンフィレグリンの関連について
    Shinomiya Hitomi, 伊藤 洋平, 久保 美恵, 米澤 宏一郎, Ohtsuki Naoki, 岩江 信法, 稲垣 宏, Nibu Ken-ichi
    第40回日本頭頸部癌学会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference
    Poster presentation

  • 同時併用化学放射線療法を施行した進行期喉頭癌,下咽頭癌症例におけるTalk Score の検討
    高橋 美貴, 松井 美緒, 涌井 絵美, Kiyota Naomi, Sasaki Ryohei, Ohtsuki Naoki, Usami Makoto, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 当科で放射線治療を施行した下咽頭癌T1・T2症例の検討
    古川 竜也, Ohtsuki Naoki, Shinomiya Hirotaka, 小松 弘和, Morimoto Koichi, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • Outcomes after radiation therapy for recurrent carcinoma of the oral tongue
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, 西川遼, Kiyota Naomi, Minamikawa Tsutomu, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, 日本頭頸部癌学会, 大宮, Domestic conference
    Oral presentation

  • Partial maxillary swing approach and Infratemporal approach for three malignant tumors inpterygopalatine fossa
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    7th international congress of the world federation of the skull base society, Jun. 2016, English, world federation of the skull base society, 大阪, International conference
    Poster presentation

  • First-Line treatment with Cetuximab-based Combination Therapy for Recurrent/Metastatic Head and Neck Cancer: A single institution experience
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Morimoto Koichi, Shinomiya Hirotaka, Ejima Yasuo, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    第40回日本頭頸部癌学会, Jun. 2016, English, 日本頭頸部癌学会, 埼玉, Domestic conference
    Oral presentation

  • First-line Treatment of Recurrent/Metastatic Head and Neck Cancer with or without Cetuximab
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Morimoto Koichi, Shinomiya Hirotaka, Ejima Yasuo, Yoshida Kenji, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    The 40th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2016, Japanese, Japan Society for Head and Neck Cancer, Saitama, Japan, 埼玉、ソニックシティー, Domestic conference
    Oral presentation

  • 嗅覚同定能の加齢性変化についての検討
    Fujio Kumi, Inokuchi Gou, 黒木 俊介, 福田 有里子, Nibu Ken-ichi
    第117回日本耳鼻咽喉科学会, May 2016, Japanese, 日本耳鼻咽喉科学会, 名古屋, Domestic conference
    Oral presentation

  • 嗅覚障害罹病期間と嗅球体積の関係についての検討
    黒木 俊介, Fujio Kumi, 福田 有里子, 中山 正子, Katsunuma Sayaka, Inokuchi Gou, Nibu Ken-ichi
    The 117th Annual Meeting of the ORL Society of Japan, May 2016, Japanese, The Oto-Rhino-Laryngolocial Society of Japan, 名古屋, Domestic conference
    Oral presentation

  • 喉頭蓋病変に対する経口切除後の摂食・嚥下状態についての臨床検討
    古川竜也, Morimoto Koichi, 小松弘和, 山村悠大, 梶本康幸, 高原慎一, Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    117th Annual Meeting of ORL Society of Japan, May 2016, Japanese, ORL Society of Japan, 名古屋, Domestic conference
    Oral presentation

  • 感染症科コンサルトとなった頭頸部癌症例 検討 〜頭頸部癌診療における感染症科医 役割〜
    小山泰司, Nibu Ken-ichi
    第117回日本耳鼻咽喉科学会, May 2016, Japanese, 日本耳鼻咽喉科学会, NewOrleans, Domestic conference
    Oral presentation

  • 再発転移頭頸部扁平上皮癌1st line化学療法におけるセツキシマブ併用効果。
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Toyoda Masanori, 茶屋原 菜穂子, 後藤 秀彰, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第113回日本内科学会総会, Apr. 2016, Japanese, 日本内科学会, 東京, Domestic conference
    Poster presentation

  • 再発・転移頭頸部扁平上皮癌におけるプラチナ耐性獲得時の血液学的予後予測因子に関する検討
    今村 善宣, Kiyota Naomi, 後藤 秀彰, 竹中 圭, 西村 明子, 茶屋原 菜穂子, Toyoda Masanori, Mukohara Toru, Nibu Ken-ichi, Minami Hironobu
    第113回日本内科学会総会, Apr. 2016, Japanese, 日本内科学会, 東京, Domestic conference
    Poster presentation

  • Definitive Radiotherapy for T3/T4 Hypopharyngeal Squamous Cell Carcinoma
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Miki Saito, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 75th Annual Meeting of the Japan Radiological Society, Apr. 2016, Japanese, Japan Radiological Society, 横浜, Domestic conference
    Oral presentation

  • 甲状軟骨骨折を認めた14歳少女に対して整復術を施行した症例
    Morimoto Koichi, 四宮 弘隆, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第28回日本喉頭科学会, Mar. 2016, Japanese, 日本喉頭科学会, 大阪, Domestic conference
    Poster presentation

  • 気管食道瘻の食道側粘膜に肺癌の転移を来し治療に難渋した1例
    四宮 弘隆, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第28回日本喉頭科学会, Mar. 2016, Japanese, 日本喉頭科学会, 大阪, Domestic conference
    Poster presentation

  • Prognostic value ofALDH potymorphisms in Japanease patients with oropharyngeal cancer
    四宮 弘隆, 四宮 瞳, Ohtsuki Naoki, Nibu Ken-ichi
    16th joint meeting of otorhynoralyngology head and neck, Mar. 2016, English, 東京, International conference
    Poster presentation

  • Prognostic value of ALDH polymorphism in Japanese patients with oropharyngeal cancer
    Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi
    16thJapan- Korea joint meeting of otorhinolaryngology head and neck surgery, Mar. 2016, English, 日本韓国耳鼻咽喉科学会, 東京, International conference
    Poster presentation

  • Metabolomic profiling of inner ear fluid using gas chromatography/mass spectrometry in guinea pig cochlea
    Fujita Takeshi, Yamashita Daisuke, Yuriko Fukuda, Go Inokuchi, Hasegawa Shingo, Naoki Otsuki, Nibu Ken-ichi
    16th Japan-Korea Joiint meeting of otorhinolaryngology-Head and Neck Surgery, Mar. 2016, English, 慶応大学耳鼻咽喉科, 東京, International conference
    Oral presentation

  • 声門閉鎖術術後の嚥下改善についての検討
    Komatsu Hirokazu, 梶本 康幸, 髙原 慎一, 古川 竜也, 涌井 絵美, 高橋 美貴, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第39回日本嚥下医学会総会, Feb. 2016, Japanese, 日本嚥下医学会, 大阪, Domestic conference
    Oral presentation

  • 鈍的外傷による甲状軟骨骨折に対して整復術を施行した症例
    Morimoto Koichi, 四宮 弘隆, Saito Miki, Nibu Ken-ichi
    第31回西日本音声外科研究会, Jan. 2016, Japanese, 西日本音声外科研究会, 松山, Domestic conference
    Oral presentation

  • 頭頸部癌治療後に声門閉鎖術を施行した3症例
    Komatsu Hirokazu, 梶本 康幸, 髙原 慎一, 古川 竜也, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第26回日本頭頸部外科学会総会, Jan. 2016, Japanese, 日本頭頸部外科学会, 愛知, Domestic conference
    Oral presentation

  • 頭蓋内浸潤を呈するも、内視鏡下摘出が可能であった嗅神経芽細胞腫の一例
    梶本 康幸, 四宮 弘隆, Fujio Kumi, Inokuchi Gou, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    第26回日本頭頸部外科学会総会, Jan. 2016, Japanese, 日本頭頸部外科学会, 愛知, Domestic conference
    Oral presentation

  • 当院において進行口腔癌根治手術に併施した嚥下機能改善手術についての検討
    古川 竜也, Komatsu Hirokazu, 梶本 康幸, 高原 慎一, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第26回日本頭頸部外科学会, Jan. 2016, Japanese, 日本頭頸部外科学会, 名古屋, Domestic conference
    Oral presentation

  • 診療ガイドラインUpdate 頭頸部癌
    Nibu Ken-ichi
    第29回日本耳鼻咽喉科学会専門医講習会, Dec. 2015, Japanese, 日本耳鼻咽喉科学会, 札幌, Domestic conference
    Public discourse

  • Synergistic action of nectins and cadherins establish the mosaic cellular pattern of the olfactory epithelium
    Katsunuma Sayaka, Togashi Hideru, Nibu Ken-ichi
    13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, Dec. 2015, English, Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, 東京都千代田区, International conference
    Oral presentation

  • Symposium 2: Surgery for Metastatic Lymph Nodes
    Nibu Ken-ichi
    1st Congress of Asia-Pacific Society of Thyroid Surgery, Nov. 2015, English, Asia-Pacific Society of Thyroid Surgery, Seoul, Korea, International conference
    [Invited]
    Nominated symposium

  • RADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITE
    Inoue Yukako, Yoshida Kohsuke, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, R.Nishikawa, Y.Matsuo, H.Nishimura, N.Otsuki, Saito Miki, Kiyota Naomi, Nibu Ken-ichi, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Prognostic value of FDG PET imaging in pharyngeal cancer patients treated with radiotherapy alone or chemoradiotherapy
    Ishihara Takeaki, Kazuhiro Kitajima, Yuko Suenaga, Ejima Yasuo, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Kiyota Naomi, Takahashi Satoru, Sasaki Ryohei
    The 28th Annual Meeting of the Japanese Society for Radiation Oncology, Nov. 2015, Japanese, JASTRO, 群馬, Domestic conference
    Oral presentation

  • Management of locally advanced thyroid cancer. Trachea and Larynx
    Ohtsuki Naoki, Nibu Ken-ichi
    1st Congress of Asia-Pacific thyroid surgery, Nov. 2015, English, Asia-Pacific Society of thyroid surgery, Seoul, Korea, International conference
    [Invited]
    Nominated symposium

  • Contemporary Management of Oral Cancer” -Surgery of the Primary-
    Nibu Ken-ichi
    ASEAN ORL-HNS Congress, Nov. 2015, English, 16th ASEAN ORL-HNS Congress, Chiang Mai, Thailand, International conference
    [Invited]
    Nominated symposium

  • 頬部痛を主訴とした 眼窩下蜂巣炎の一例
    山村悠大, 髙原慎一, Fujio Kumi, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi
    The 54th Annual Meeting of the Japanese Rhinologic Society, Oct. 2015, Japanese, 日本鼻科学会, 広島, Domestic conference
    Oral presentation

  • 内視鏡下前頭蓋底手術における コブレーターの使用経験
    梶本康幸, 四宮弘隆, Fujio Kumi, Inokuchi Gou, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    第17回耳鼻咽喉科手術支援システム・ナビ研究会, Oct. 2015, Japanese, 名古屋市立大学耳鼻咽喉科, 名古屋, Domestic conference
    Oral presentation

  • 症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果(会議録)
    柴田智久, Yamashita Daisuke, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi
    The 25th Annual Meeting of the Japan Otologic Soeicty, Oct. 2015, Japanese, 日本耳科目学会, 長崎, Domestic conference
    Oral presentation

  • 甲状腺全摘術後に発症した異所性・異時性副甲状腺癌の1例
    梶本 康幸, Fujio Kumi, 四宮 瞳, Komatsu Hirokazu, 李 佳奈, Yamashita Daisuke, Ohtsuki Naoki, 牧野 邦彦, Nibu Ken-ichi
    第48回甲状腺外科学会学術集会, Oct. 2015, Japanese, 日本甲状腺外科学会, 東京, Domestic conference
    Poster presentation

  • 経鼻内視鏡アプローチを行い、 術後嗅覚を温存しえた嗅溝部髄膜腫の1例
    Inokuchi Gou, Fujio Kumi, 高原 慎一, Hasegawa Shingo, Nibu Ken-ichi
    The 54th Annual Meeting of the Japanese Rhinologic Society, Oct. 2015, Japanese, 日本鼻科学会, 広島, Domestic conference
    Oral presentation

  • Gene Testing for Head and Neck Cancer
    Nibu Ken-ichi
    第53回日本癌治療学会, Oct. 2015, Japanese, 日本癌治療学会, 京都, Domestic conference
    [Invited]
    Invited oral presentation

  • 眼窩内へ進展した 多発性血管炎性肉芽腫症
    梶本康幸, Fujio Kumi, Inokuchi Gou, 黒田浩之, Nibu Ken-ichi
    The 54th Annual Meeting of the Japanese Rhinologic Society, Oct. 2015, Japanese, 日本鼻科学会, 広島, Domestic conference
    Oral presentation

  • 遺伝性出血性毛細血管拡張症（HHT）関連 鼻出血に対するエストリオール軟膏の治療効果
    髙原慎一, Inokuchi Gou, 黒木俊介, Fujio Kumi, Hasegawa Shingo, Nibu Ken-ichi
    The 54th Annual Meeting of the Japanese Rhinologic Society, Oct. 2015, Japanese, 日本鼻科学会, 広島, Domestic conference
    Oral presentation

  • Radiotherapy for T3/T4 squamous cell carcinoma of hypopharynx: retrospective comparison between definitive radiotherapy and surgery followed by postoperative radiotherapy
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    57th Annual Meeting of ASTRO, Oct. 2015, English, ASTRO, San Antonio, USA, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: a Dose-Volume Histogram Analysis
    Miyawaki Daisuke, N. Mukumoto, Ejima Yasuo, Yoshida Kohsuke, Ishihara Takeaki, Kiyota Naomi, Saito Miki, N. Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    European Cancer Congress 2015, Sep. 2015, English, European Cancer Congress, Vienna, Austria, Austria, International conference
    Poster presentation

  • Molecular Diagnosis of Head And Neck Cancer
    Nibu Ken-ichi
    25th Anniversary International Conference of Korean Society of Thyroid-Head and Neck Surgery, Sep. 2015, English, Korean Society of Thyroid-Head and Neck Surgery, Busan, Korea, International conference
    Keynote oral presentation

  • ASNO sponsored Symposium “Oral Cavity Cancer”-Surgery of the Primary-
    Nibu Ken-ichi
    AAO-HNSF 2015 Annual Meeting & OTO EXPO, Sep. 2015, English, American Academy of Otolaryngology-Head and Neck Surgery, Dalas, USA, International conference
    Public symposium

  • Albatorss Case: Cancers Involving Pterygopalatine Fossa
    Nibu Ken-ichi
    25th Anniversary International Conference of Korean Society of Thyroid-Head and Neck Surgery, Sep. 2015, English, Korean Society of Thyroid-Head and Neck Surgery, Busan, Korea, International conference
    [Invited]
    Nominated symposium

  • 嗅上皮の細胞の並び方を形成するネクチンとカドヘリンの協調的な働き
    Katsunuma Sayaka, Togashi Hideru, Nibu Ken-ichi
    第33回 耳鼻咽喉科ニューロサイエンス研究会, Aug. 2015, Japanese, 耳鼻咽喉科ニューロサイエンス研究会, 大阪市, Domestic conference
    Oral presentation

  • Prognostic Value of ALDH Polymorphism in Japanese Patients with Oropharyngeal Cancer
    Nibu Ken-ichi
    2015 Annual CORLAS Meeting, Aug. 2015, English, Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum, San Francisco, USA, International conference
    [Invited]
    Nominated symposium

  • Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明
    Inokuchi Gou, 薛富義, Kikkawa Satoshi, Terashima Toshio, 四宮瞳, Yamashita Daisuke, Nibu Ken-ichi
    第33回耳鼻咽喉科ニューロサイエンス研究会, Aug. 2015, Japanese, 神戸大学耳鼻咽喉科, 大阪, Domestic conference
    Oral presentation

  • Distinct approaching routes to para-median skull base lesions in the endoscopic endonasal surgery.
    Taniguchi Masaaki, 阿久津 宣行, Mizukawa Katsu, Inokuchi Gou, Kimura Hidehito, Nibu Ken-ichi, Kohmura Eiji
    第27回日本頭蓋底外科学会, Jul. 2015, Japanese, 日本頭蓋底外科学会, 名古屋, Domestic conference
    Public symposium

  • Prognostic Value of the Inflammation Markers for Platinum Refractory Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
    Yoshinori Imamura, Kiyota Naomi, Naoki Otsuki, Toyoda Masanori, Chayahara Naoko, Meiko Nishimura, Mukohara Toru, Nibu Ken-ichi, Sasaki Ryohei, Minami Hironobu
    第13回日本臨床腫瘍学会学術集会, Jul. 2015, English, 日本臨床腫瘍学会, 札幌, Domestic conference
    Poster presentation

  • RADIOTHERAPY FOR CERVICAL LYMPH NODE METASTASES OF UNKNOWN PRIMARY SITE
    井上由子, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, ノルシャズリナ, 西川遼, 松尾圭朗, 西村英輝, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • Oncological and Functional outcome of locally advanced (T3/T4) hypopharyngeal cancer
    Komatsu Hirokazu, Hirotaka Shinomiya, Morimoto Koichi, Saito Miki, Naoki Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology, Jun. 2015, English, Asian Society of Head and Neck Oncology, 兵庫, International conference
    Poster presentation

  • Treatment strategy and outcome for temporal bone carcinoma in advanced stage
    Hasegawa Shingo, Nibu Ken-ichi
    第39回日本頭頸部癌学会＆第4回アジア頭頸部癌学会, Jun. 2015, English, 日本頭頸部癌学会, 神戸, International conference
    [Invited]
    Nominated symposium

  • Treatment outcomes of definitive radiotherapy in patients with T3N0M0 laryngeal cancer
    Ishihara Takeaki, Yoshiro Matsuo, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Morimoto Koichi, Saito Miki, Naoki Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    4th Congress of Asian Society of Head and Neck Oncology 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, Japanese, Japan Society for Head and Neck Cancer, 神戸, Domestic conference
    Poster presentation

  • Treatment outcome of transoral resection using CO2 LASER against early glottic cancers
    Morimoto Koichi, Hirotaka Shinomiya, Saito Miki, Nibu Ken-ichi
    第39回日本頭頸部癌学会（第4回アジア頭頸部癌学会）, Jun. 2015, English, 日本頭頸部癌学会, 神戸, Domestic conference
    Oral presentation

  • Treatment outcome of parotid cancers
    四宮 瞳, Ohtsuki Naoki, Yamashita Daisuke, 今村 善宣, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    2015年6月3日～6日の4th Congress of Asian Society of Head and Neck Oncology, Jun. 2015, English, 日本頭頸部癌学会, 神戸, International conference
    Oral presentation

  • The Utility of Dual-Time-Point FDG PET Imaging in Patients with Oral Tongue Squamous Cell Carcinoma.
    Yonezawa N, Minamikawa Tsutomu, Takahashi Yutaka, Komatsu Hirokazu, Kitajima K, Sasaki Ryohei, Nibu Ken-ichi, Komori Takahide
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, Japanese, The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 神戸, Domestic conference
    Oral presentation

  • Radiotherapy for posterior pharyngeal wall cancer of oropharynx and/or hypopharynx
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, 神戸国際会議場, 神戸, International conference
    Poster presentation

  • Prognostic value of the Inflammation Scores for Platinum Refractory Head and Neck cancer.
    今村善宣, Kiyota Naomi, Ohtsuki Naoki, Saito Miki, Morimoto Koichi, Komatsu Hirokazu, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 上薗玄, Ishihara Takeaki, Minamikawa Tsutomu, Sasaki Ryohei, Nibu Ken-ichi
    第39回日本頭頸部癌学会学術集会, Jun. 2015, English, 日本頭頸部癌学会, 神戸, Domestic conference
    Oral presentation

  • Postoperative complications in skull base surgery for nasal and paranasal malignant tumors involving skull base
    手島 直則, 四宮 弘隆, Ohtsuki Naoki, Kimura Hidehito, Hashikawa Kazunobu, Kohmura Eiji, Nibu Ken-ichi
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology (ASHNO) and 39th Annual Meeting of Japan Society for Head and Neck Cancer (JSHNC), Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • Definitive radiotherapy for T3/T4 hypopharyngeal squamous cell carcinoma
    Yoshiro Matsuo, Yoshida Kenji, Yuko Inoue, Ryo Nishikawa, Nor Shazrina, Ishihara Takeaki, Miyawaki Daisuke, Ejima Yasuo, Hideki Nishimura, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    4th Congress of Asian Society of Head and Neck Oncology, 39th Annual Meeting of Japan Society for Head and Neck Cancer, Jun. 2015, English, Japan Society for Head and Neck Cancer, 神戸, International conference
    Poster presentation

  • Clinical Study of Neck Dissection for any TN1 with Oral Squamous Cell Carcinoma
    Kakei Y, Minamikawa Tsutomu, Komatsu Hirokazu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Komori Takahide
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, Japanese, The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 神戸, Domestic conference
    Oral presentation

  • Analysis of the hyoid motion of tongue cancer patients.
    Takahashi Yutaka, Minamikawa Tsutomu, Yonezawa N, Komatsu Hirokazu, Saito Miki, Nibu Ken-ichi, Komori Takahide
    The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, Japanese, The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 神戸, Domestic conference
    Oral presentation

  • ADH,ALDH polymorphisms in Patients with the oropharyngeal carcinomas
    四宮 弘隆, 四宮 瞳, Ohtsuki Naoki, Nibu Ken-ichi
    第4回アジア頭頸部癌学会, Jun. 2015, English, アジア頭頸部癌学会, 神戸, International conference
    Poster presentation

  • 軟素材による外耳道後壁再建を行った後天性真珠腫症例の検討
    柴田智久, Fujita Takeshi, 小嶋康隆, Inokuchi Gou, Yamashita Daisuke, Hasegawa Shingo, Nibu Ken-ichi
    The 116th Annual Meeting of ORL Society of Japan, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 当科嗅覚外来受診患者の MRI画像による評価
    黒木俊介, Fujio Kumi, 福田有里子, 中山正子, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi
    The 116th Annual Meeting of ORL Society of Japan, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 当科における 鼻出血入院症例の検討
    池本和希, 高原慎一, Inokuchi Gou, Fujio Kumi, Nibu Ken-ichi
    The 116th Annual Meeting of ORL Society of Japan, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 高齢健常ボランティアに対する嗅覚検査
    Fujio Kumi, Inokuchi Gou, 髙原慎一, 黒木俊介, 中山正子, 福田有里子, Hasegawa Shingo, Nibu Ken-ichi
    The 116th Annual Meeting of ORL Society of Japan, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 感冒後嗅覚障害とパーキンソン病 (PD) における嗅覚障害の検討
    Fujio Kumi, Inokuchi Gou, 福田有里子, 黒木俊介, 中山正子, Hasegawa Shingo, Nibu Ken-ichi
    The 116th Annual Meeting of ORL Society of Japan, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 外側側頭骨切除における鼓室前壁処理の一工夫～鼓索神経追跡法～
    Hasegawa Shingo, Yamashita Daisuke, Nibu Ken-ichi
    第116回日本耳鼻咽喉科学会, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • パーキンソン病症例と感冒後嗅覚障害症例における嗅覚障害の検討
    Fujio Kumi, Inokuchi Gou, 黒木俊介, 中山正子, Hasegawa Shingo, Nibu Ken-ichi
    第116回日本耳鼻咽喉科学会総会・学術講演会, May 2015, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • Radioimmunotherapy with 90Y ibritumomab tiuxetan for low grade malignant lymphoma.
    R Nishikawa, Yoshida Kohsuke, Miyawaki Daisuke, Ejima Yasuo, Ishihara Takeaki, Y Matsuo, NS Sulaiman, Inoue Yukako, H Nishimura, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, 京都, International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Ishihara Takeaki, Kiyota Naomi, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    15th International Congress of Radiation Research, May 2015, English, International Congress of Radiation Research, 京都, International conference
    Poster presentation

  • 当科における声帯病変に対するCO2レーザー切除症例の検討
    Morimoto Koichi, 四宮 弘隆, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第27回日本喉頭科学会, Apr. 2015, Japanese, 日本喉頭科学会, 東京, Domestic conference
    Oral presentation

  • Prognostic value of FDG PET imaging in patients with pharyngeal cancer and who received definitive radiotherapwith radiotherapy or without chemotherapy
    Ishihara Takeaki, Kazuhiro Kitajima, Yuko Suenaga, Ejima Yasuo, Saito Miki, Naoki Otsuki, Nibu Ken-ichi, Kiyota Naomi, Takahashi Satoru, Sasaki Ryohei
    The 74th Annual Meeting of the Japan Radiological Society, Apr. 2015, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Poster presentation

  • Management of Ear Cancer
    Nibu Ken-ichi
    2016 International Congress of Koeran Society of Otohinolaryngology-Head a& Neck Srugery, Apr. 2015, English, Koeran Society of Otohinolaryngology-Head a& Neck Srugery, Seoul, Korea, International conference
    [Invited]
    Nominated symposium

  • Efficacy of Antiviral Treatment on Abnormal Auditory Brainstem Responses in Congenital Cytomegalovirus-Infected Infants
    森岡 一郎, 西田 浩輔, 山下 大輔, 小林 曜子, 中町 祐司, 今西 孝充, Deguchi Masashi, Tanimura Kenji, Kawano Seiji, Nibu Ken-ichi, Iijima Kazumoto, Yamada Hideto
    2015 Pediatric Academic Society Annual Meeting, Apr. 2015, English, osaka, Japan, International conference
    Poster presentation

  • 鼻腔腫瘍に対する放射線治療の経験
    清家翔平, Yoshida Kenji, Miyawaki Daisuke, Ishihara Takeaki, 井上由子, 松尾圭朗, 西川 遼, ノルシャズリナ, Ejima Yasuo, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第309 回日本医学放射線学会関西地方会, Feb. 2015, Japanese, 日本医学放射線学会関西地方会, 大阪, Domestic conference
    Oral presentation

  • 上顎洞癌に対する超選択的動注化学療法併用放射線療法の治療成績
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Ishihara Takeaki, ノルシャズリナ, Yamaguchi Masato, 四宮弘隆, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第27回学術大会, Dec. 2014, Japanese, 日本放射線腫瘍学会, 横浜、パシフィコ横浜, 上顎洞扁平上皮癌に対する超選択的動注化学療法併用放射線療法の成績を遡及的に検討, Domestic conference
    Poster presentation

  • 治療前FDG-PETによる喉頭癌の再発予測
    Kitajima Kazuhiro, 末永裕子, 神田知紀, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei, Komatsu Hirokazu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Minamikawa Tsutomu, Kiyota Naomi, Sugimura Kazuro
    第54回日本核医学会学術総会, Nov. 2014, Japanese, The Japan Nuclear Medicine, 大阪, Domestic conference
    Oral presentation

  • 喉頭蓋病変に対して経口的切除を施行した5症例の検討
    Morimoto Koichi, Saito Miki, 四宮 弘隆, Ohtsuki Naoki, Nibu Ken-ichi
    第66回日本気管食道科学会, Nov. 2014, Japanese, 日本気管食道科学会, 高知, Domestic conference
    Poster presentation

  • “ベンダ変更＋システム更新”時のパス電子化：現実・現状と課題
    Takaoka Yutaka, 松本 将典, 香川 泰俊, 関口 紗代, 清水 由欣子, 池上 峰子, 石坂 雅志, 四宮 弘隆, 西岡 達也, Nibu Ken-ichi
    第15回日本クリニカルパス学会学術集会, Nov. 2014, Japanese, 日本クリニカルパス学会, あわら, 【はじめに】当院は2008年3月にNECのMegaOakHRを導入し、クリニカルパスの電子化を3パスのみで試行した。その後、2014年1月に日本IBMのCISへシステム更新し、パス完全電子化の取り組みを開始したので報告する。【作成】システム更新前に承認されていたパスは205あり、パス電子化が容易な88パスを初期移行対象とした。その際、仕様書作成の段階で “高頻度に使用される50個程度のパスを使える状態とする”等の文言を入れておらず、パス委員が全電子パスを作成することになった。各マスタの整備完了後に電子パス作成が可能となり、システム移行直前から作成を開始した。【運用】電子パス作成開始直後に継続指示を組み込めないバグが、また看護ケア関連は組み込めないことが判明した。そこで、看護ケアは看護システム側からケアセットで出し、継続指示は不具合修正と関連のマスタ整, Domestic conference
    Poster presentation

  • 色素性乾皮症における聴覚障害の検討
    Yamashita Daisuke, Fujita Takeshi, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi
    第24回日本耳科学会総会・学術講演会, Oct. 2014, Japanese, 日本耳科学会, 新潟, Domestic conference
    Oral presentation

  • Retrospective analysis of whole brain radiotherapy for brain metastases
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Y Imamura, H Shinomiya, Komatsu Hirokazu, H Fujio, Morimoto Koichi, Saito Miki, N Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, We retrospectively reviewed 9 cases who underwent radiotherapy with Cetuximab concurrently. Primary tumor response and acute toxicity are reported. Although mucositis was the most remarkable adverse events, one patient developed grade 5 drug-induced interstitial lung disease., International conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kohsuke, H Nishimura, Kiyota Naomi, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, Kobe, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution, International conference
    Poster presentation

  • Experience of radiotherapy plus cetuximab for head and neck cancer
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, Ishihara Takeaki, Y Imamura, H Shinomiya, Komatsu Hirokazu, H Fujio, Morimoto Koichi, Saito Miki, N Otsuki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 15th Asian Oceanian Congress of Radiology AOCR 2014, Sep. 2014, English, Asia Oceania Congress of Radiology, Kobe, International conference
    Poster presentation

  • Partial Laryngectomy for Radiation-Failure
    Morimoto Koichi, Naoki Otsuki, Saito Miki, Nibu Ken-ichi
    5th World Congress of IFHNOS & Annual Meeting of the AHNS, Jul. 2014, English, IFHNOS, New York, USA, International conference
    Poster presentation

  • Clinicopathological Analysis of Salivary Duct Carcinoma and Salivary Gland Adenocarcinoma, N.O.S
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, 平井 千穂子, Itoh Tomoo, 船越 洋平, Sasaki Ryohei, Nibu Ken-ichi, Mukohara Toru, Minami Hironobu
    The 12th Annual Meeting of Japanese Society of Medical Oncology, Jul. 2014, English, Japanese Society of Medical Oncology, 福岡, Domestic conference
    Poster presentation

  • 免疫組織化学染色による唾液腺導管癌15例の検討．
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 免疫組織化学染色による唾液腺導管癌15例の検討
    今村善宣, Kiyota Naomi, Ohtsuki Naoki, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • Experience of radiotherapy plus cetuximab for head and neck cancer
    Uezono Haruka, Ejima Yasuo, Miyawaki Daisuke, 今村善宣, 四宮弘隆, Komatsu Hirokazu, Fujio Kumi, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Poster presentation

  • 当科における中咽頭癌症例の臨床的検討
    四宮弘隆, 四宮 瞳, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象
    高橋美貴, 小坂奈々, Usami Makoto, 中川絵美, Saito Miki, Ohtsuki Naoki, Ejima Yasuo, Miyawaki Daisuke, Sasaki Ryohei, Kiyota Naomi, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 中咽頭癌に対する化学放射線療法におけるPEG留置患者の栄養投与量と有害事象を検討, Domestic conference
    Oral presentation

  • 進行期喉頭癌・下咽頭癌に対する治療戦略
    Ohtsuki Naoki, 四宮弘隆, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • 食道癌術後に生じた胃管気管瘻に対し有茎大胸筋皮弁が有用であった1例
    楠元 順哉, Hashikawa Kazunobu, Ohtsuki Naoki, Nibu Ken-ichi, Terashi Hiroto
    第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, 四宮弘隆, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, 上顎洞扁平上皮癌に対する放射線治療成績を検討, Domestic conference
    Poster presentation

  • 口腔癌ｃN1症例に対する頸部郭清術の郭清範囲についての検討
    筧 康正, Minamikawa Tsutomu, Komatsu Hirokazu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Komori Takahide
    第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 下顎区域切除後における切除範囲別の咀嚼機能と口腔QOLの評価
    仲村 百合香, Shibuya Yasuyuki, 竹内 惇平, 小林 正樹, Hashikawa Kazunobu, Nibu Ken-ichi, Komori Takahide
    第38回日本頭頸部癌学会, Jun. 2014, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • T3N0-1声門癌に対する喉頭温存を目的とした根治的化学放射線治療の検討
    Sasaki Ryohei, 松尾圭朗, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, 今村善宣, Kiyota Naomi, 四宮弘隆, Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    The 38th annual meeting of the Japan Society for Head and Neck Cancer, Jun. 2014, Japanese, Japan Society for Head and Neck Cancer, 東京, Domestic conference
    Oral presentation

  • 当科における緊急気管切開術についての検討
    Komatsu Hirokazu, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    日本耳鼻咽喉科学会, May 2014, Japanese, 小宗 静男, 福岡, Domestic conference
    Oral presentation

  • 当院における唾液腺導管癌15例の臨床病理学的検討．
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, 平井 千浦子, Toyoda Masanori, Chayahara Naoko, 船越 洋平, Mukohara Toru, Nibu Ken-ichi, Minami Hironobu
    第111回日本内科学会総会, Apr. 2014, Japanese, 日本内科学会, 東京, Domestic conference
    Poster presentation

  • Definitive radiotherapy for T3 laryngeal cancer
    松尾圭朗, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, 松本葉子, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, English, The Japan Radiological Society, 横浜、パシフィコ横浜, [Objective] The purpose of this study is to evaluate the results of T3 laryngeal cancer with radiotherapy in our institution.[Materials and Methods] Between 2006 and 2013, 20 patients with T3 laryngeal cancer treated with radiotherapy in our institution. Sixteen patients was diagnosed with N0, 2 patients did with N1, 1 patient did with N2, and 1 patient did with N3 disease. Sev, Domestic conference
    Oral presentation

  • 偶然発見された副咽頭間隙へ伸展を示した三叉神経鞘腫の1例
    河合 恵美子, 繁治 純, 小島 康隆, 阿久津 宣行, Tanaka Kazuhiro, Itoh Tomoo, Nibu Ken-ichi, Kohmura Eiji
    第67回日本脳神経外科学会近畿支部学術集会/第69回近畿脊髄外科研究会, Apr. 2014, Japanese, 日本脳神経外科学会, 大阪, Domestic conference
    Oral presentation

  • Treatment outcomes of radiotherapy for T1/T2 supraglottic carcinoma
    松本葉子, Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Yoshida Kenji, Sasaki Ryohei, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    The 73rd Annual Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, Domestic conference
    Poster presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck
    Miyawaki Daisuke, Ejima Yasuo, Uezono Haruka, Yoshida Kenji, 西村英輝, 岡本欣晃, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    The 73rd Annial Meeting of the Japan Radiological Society, Apr. 2014, Japanese, The Japan Radiological Society, 横浜、パシフィコ横浜, The purpose of this study was to compare the risk of HT in squamous cell carcinoma of the head and neck undergoing treatment with CCRT or RT alone at our institution., Domestic conference
    Poster presentation

  • Developmental evaluation in the patients with xeroderma pigmentosum group A, using Enjoji development examination.
    Sakai Yoshitada, R Saura, Ueda Takehiro, Yamashita Daisuke, N Otsuki, Nakagawa Taku, Toyoshima Daisaku, Morisada Naoya, Eiji Nakano, Ryusuke Ono, Masaki Taro, Takeuchi Seiji, Nibu Ken-ichi, Kanda Fumio, Nishigori Chikako
    International Symposium on Xeroderma Pigmentosum and Related Disease, Mar. 2014, English, 難病医学研究財団, Kobe, International conference
    [Invited]
    Nominated symposium

  • 頭頸部癌に対するセツキシマブ併用放射線治療の初期経験
    下山真介, Uezono Haruka, 松尾圭朗, ノルシャズリナ, 松本葉子, Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, Sasaki Ryohei, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi
    第305回公益社団法人日本医学放射線学会関西地方会, Nov. 2013, Japanese, 日本医学放射線学会関西地方会, 大阪(ブリーゼプラザ), Domestic conference
    Oral presentation

  • Synergistic antitumor effect of the combination of adenoviral gene therapy and immunotherapy for head and neck cancer
    安藤 聡志, 斉藤 大樹, 森下 直矢, Kawabata Masato, Ohtsuki Naoki, Nibu Ken-ichi, Fujisawa Masato, Shirakawa Toshiro
    The 17th International Congress of Personalized Medicine, Nov. 2013, Japanese, International Society of Personalized Medicine, 神戸, Domestic conference
    Poster presentation

  • 放射線療法後に長期経過観察した上咽頭癌症例における晩期有害反応の検討
    Sasaki Ryohei, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 岡本欣晃, Ejima Yasuo, Yamashita Daisuke, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • 中・下咽頭扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, Ejima Yasuo, Yoshida Kenji, Uezono Haruka, 西村英輝, 岡本欣晃, 酒井英郎, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • T1／2声門上癌に対する放射線治療成績の検討
    松本葉子, Yoshida Kenji, Uezono Haruka, Miyawaki Daisuke, Ejima Yasuo, 西村英輝, Sasaki Ryohei, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森（ホテル青森、リンクステーションホール青森）, Domestic conference
    Oral presentation

  • Radiation Induced Hypothyroidism in Squamous Cell Carcinoma of the Head and Neck: Comparison between Concurrent Chemoradiotherapy and Radiation Therapy Alone
    Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, H Nishimura, NS Sulaiman, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, International conference
    Poster presentation

  • Functional outcomes of the facial nerve after post operative radiation therapy for high risk parotid gland malignancies underwent radical surgery with facial nerve resection and reconstructive surgery.
    O Muraoka, H Nishimura, Miyawaki Daisuke, Yoshida Kohsuke, Ejima Yasuo, Y Okamoto, K Hashikawa, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    55th Annual meeting ASTRO, Sep. 2013, English, ASTRO, Atlanta, GA, USA, The effect of postoperative radiation treatment (PORT) for facial nerve reconstruction is not fully investigated. The purpose of this study is to evaluate the outcomes of patients treated with the combination of surgery and PORT.Between 2000 and 2009, 27 patients with parotid gland carcinomas were treated with curative surgery and PORT. Nineteen patients received facial nerve s, International conference
    Poster presentation

  • 25 year experience with primary salivary gland carcinoma at a single institution in Japan European Journal of Cancer 49,
    Yoshinori Imamura, Kiyota Naomi, Naoki Otsuki, Chihoko Hirai, Yohei Funakoshi, Mukohara Toru, Yamashita Daisuke, Itoh Tomoo, Minami Hironobu, Nibu Ken-ichi
    ECCO2013, Sep. 2013, English, European CanCer Organisation, Amsterdam, Holland, This is one of the largest clinicopathological reports of major SGC from a single institution in Japan. Prognosis and prognostic factors of SGC were in accordance to previous reports., International conference
    Poster presentation

  • 嗅上皮の細胞配列を制御するネクチンの働き
    Katsunuma Sayaka, Togashi Hideru, Takai Yoshimi, Nibu Ken-ichi
    第31回耳鼻咽喉科ニューロサイエンス研究会, Aug. 2013, Japanese, 耳鼻咽喉科ニューロサイエンス研究会, 大阪, Domestic conference
    Public symposium

  • Nectins Regulate the Mosaic Cellular Pattern Formation in the Olfactory Epithelium
    Katsunuma Sayaka, Togashi Hideru, Nibu Ken-ichi, Takai Yoshimi
    16th Asian Research Symposium in Rhinology, Aug. 2013, English, 日本鼻科学会, 東京, International conference
    [Invited]
    Nominated symposium

  • Clinicopathologic Analysis of Salivary Duct Carcinoma in 15 Japanese Patients
    Yoshinori Imamura, Kiyota Naomi, Naoki Otsuki, Itoh Tomoo, Chihoko Hirai, Takanobu Shimada, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi, Mukohara Toru, Minami Hironobu
    第11回日本臨床腫瘍学会学術集会, Aug. 2013, English, 日本臨床腫瘍学会, 仙台, We hereby reported a clinicopathologic analysis of 15 Japanese patients with SDC., Domestic conference
    Poster presentation

  • SYNERGISTIC ANITITUMOR EFFECT OF THE COMBINATIION OF ADENOVIRAL GENE THERAPY AND IMMUNOTHERAPY FOR HEAD AND NECK CANCER
    安藤 聡志, 斉藤 大樹, 森下 直矢, Kawabata Masato, Ohtsuki Naoki, Nibu Ken-ichi, Fujisawa Masato, Shirakawa Toshiro
    19th Annual Meeting of Japan Society of Gene Therapy, Jul. 2013, Japanese, Japan Society of Gene Therapy, 岡山, Domestic conference
    Poster presentation

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 谷本 均, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, Sasaki Ryohei, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, 原発不明癌頸部リンパ節転移の約80％が扁平上皮癌であり、悪性黒色腫の頻度は0．9％と非常に稀である。今回我々は頸部リンパ節にのみ転移を認めた原発不明悪性黒色腫の2症例を経験した。症例1は72歳男性。2005年9月に左顎下部腫瘤を主訴に来院し、同部よりの穿刺吸引細胞診で悪性黒色腫の診断が得られた。原発巣は明らかでなく、左顎部敦清術を行った。転移リンパ節は1個であったが節外浸潤を認めたため、術後化学療法としてDAV（Dacarbazine, Nimustine, Vincristine)を8コース施行した。現在術後6年経過し、再発・転移を認めない。症例2は61歳男性。症例1と同様に原発不明悪性黒色腫の診断で左顎部敦清術を行った。多発リンパ節転移と節外浸潤を認めたため、術後にDAVを8コース施行した。現在術後2年経過し、再発・転移を認めない。原発不明悪性黒, Domestic conference
    Oral presentation

  • 鼻腔腫瘍の治療計画における不均質補正の影響
    椋本成俊, Yoshida Kenji, 赤坂浩亮, Ejima Yasuo, Miyawaki Daisuke, Uezono Haruka, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 鼻腔原発NK／T細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村英輝, Ejima Yasuo, Yoshida Kenji, Yakushijin Kimikazu, Matsuoka Hiroshi, Doi Kiyoshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 頭頸部扁平上皮癌に対する放射線治療後の甲状腺機能低下症に関する検討
    Miyawaki Daisuke, Yoshida Kenji, Ejima Yasuo, 西村英輝, 岡本欣晃, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 頭頚部傍神経節腫に対する放射線治療の経験
    酒井徹也, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, Uezono Haruka, 松本葉子, ノルシャズリナビンティスライマン, 松尾圭朗, Sasaki Ryohei, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第304回公益社団法人日本医学放射線学会関西地方会（第376回レントゲンアーベント）, Jun. 2013, Japanese, 公益社団法人日本医学放射線学会関西地方会, 大阪、ホテルエルセラーン大阪, Domestic conference
    Oral presentation

  • 当院における唾液腺導管癌15例の臨床病理学的特徴
    今村 善宣, Kiyota Naomi, Ohtsuki Naoki, 島田 貴信, Yamashita Daisuke, Sasaki Ryohei, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京, 当院におけるSDC 15例の臨床病理学的特徴を報告した。, Domestic conference
    Poster presentation

  • 当院におけるT3喉頭癌の放射線治療の経験
    松尾圭朗, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • Treatment strategy for temporal bone carcinoma-Surgery vs Chemoradiation-
    Hasegawa Shingo, Kohmura Eiji, Nibu Ken-ichi
    The 25th Annual Meeting of Japanese Society for Skull Base Surgery, Jun. 2013, Japanese, Annual Meeting of Japanese Society for Skull Base Surgery, 名古屋, 当院では安全領域をつけた外科的一塊切除と3種の抗癌剤による化学放射線同時併用(CCRT)を2本の柱として聴器癌治療を行っている。今回はその治療戦略と成績について述べる。【治療戦略】1995年以降に聴器癌71例（外耳道癌63例、中耳癌8例/扁平上皮癌68例、腺癌3例）を治療し、2005年までは手術主体の治療方針であった。現在もT1/T2例に対しては外側側頭骨切除術を、T3例に対しては側頭骨亜全摘出術を第一選択としている。一方、T4例においては手術を行っても再発する症例（硬膜広範囲進展例や頸静脈孔進展例など）を経験したことから2006年以降はDOC,CDDP,5FU(TPF)によるCCRTを導入し、T4例を中心に一部のT3例にも適応している。【成績】全体の無病3年生存率はピッツバーグ分類（2000年改訂版）のT1 100％、T2 94％、T3 80％、T, Domestic conference
    Public symposium

  • 進行舌癌に対する術後放射線治療の経験
    Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, 西村英輝, Kiyota Naomi, Minamikawa Tsutomu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 耳下腺癌／顎下腺癌術後症例に対する放射線治療の検討
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, Ejima Yasuo, Ohtsuki Naoki, Morimoto Koichi, Yamashita Daisuke, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 再発・転移頭頸部がんに対するドセタキセル・シスプラチン併用（DC）療法
    島田貴信, Kiyota Naomi, 今村善宣, Morimoto Koichi, Saito Miki, 西村英輝, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • 甲状腺原発MALTリンパ腫の治療経験
    Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, 副島俊典, Matsuoka Hiroshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 顎下腺脱分化型腺様嚢胞癌の1例
    入谷啓介, 福田有里子, Ohtsuki Naoki, Nibu Ken-ichi, ノルシャズリナビンティスライマン, Yoshida Kenji, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • 下顎切除患者における発色ガム検査の有用性
    石田 優, Shibuya Yasuyuki, 小林正樹, Shigeta Takashi, Minamikawa Tsutomu, Nibu Ken-ichi, Komori Takahide
    第37回日本頭頸部癌学会総会, Jun. 2013, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • T1／2声門上癌に対する放射線治療成績の検討
    松本葉子, Yoshida Kenji, Ejima Yasuo, Miyawaki Daisuke, 西村英輝, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, Sasaki Ryohei
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Poster presentation

  • 5年以上経過観察した上咽頭癌症例に関する放射線療法の晩期有害反応の検討
    Sasaki Ryohei, Ejima Yasuo, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, Yamashita Daisuke, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    第37回日本頭頸部癌学会, Jun. 2013, Japanese, 日本頭頸部癌学会, 新宿、東京（京王プラザホテル）, Domestic conference
    Oral presentation

  • Ten Year Experience with Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Oropharynx
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Ejima Yasuo, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sugimura Kazuro, Sasaki Ryohei
    European Congress of Radiology（ECR, Mar. 2013, English, European Society of Radiology, Austria,Vienna, Purpose/Objective(s): To assess the efficacy of radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Materials/Methods: Between July 2000 and March 2011, 98 patients with squamous cell carcinomas of the, International conference
    Poster presentation

  • 鼻腔原発NK/T 細胞リンパ腫に対する放射線治療経験
    原田 文, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡 修, ノル シャズリナ, ビンティ スライマン, 松本葉子, Nibu Ken-ichi, Matsuoka Hiroshi, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, Domestic conference
    Poster presentation

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】2000年7月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した96例を対象とした。年齢の中央値は62歳（31-96歳）、男:女=80:16であった。亜部位は前壁：側壁：後壁：上壁＝24：57：3：12、進展度はT1：T2：T3：T4a：T4b＝6：54：17：10：5、N0：N1：N2a：N2b：N2c：N3＝18：14：6：32：17：9であった。手術は13例に施行され、化学療法の併用は81例（同時併用76例）、処方線量の中央値は70Gy（60-70.8Gy）であった。【結果】経過観察期間の中央値は25.5か月(3-141か月)。3年の全生存割合は76％で、無再発生存割合は66％、局所領域制御割合は70％であった。病期別の3年全生存割合は, Domestic conference
    Poster presentation

  • 高齢頭頸部癌患者に対する放射線治療の経験 −10 年間の検討−
    Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 岡本欣晃, Ohtsuki Naoki, Nibu Ken-ichi, 副島俊典, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36％であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference
    Oral presentation

  • 顎下腺癌に対する術後放射線療法の検討
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    日本放射線腫瘍学会第25回学術大会, Nov. 2012, Japanese, 日本放射線腫瘍学会, 東京（東京国際フォーラム）, 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference
    Poster presentation

  • Patterns of Local Recurrence and Metachronous Malignancy Following Radiation Therapy for Stage I or II Hypopharyngeal Carcinoma: Role of Close Observation and Multidisciplinary Approach
    H Nishimura, Sasaki Ryohei, Yoshida Kohsuke, Miyawaki Daisuke, Y Okamoto, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi
    54th ASTRO Annual Meeting, Oct. 2012, English, ASTRO, U.S.A , Boston, International conference
    Poster presentation

  • A randomized phase II trial comparing standard pain control with or witout gabapentin for the treatment of pain related radiation-induced mucositis head and neck cancer
    Kataoka Tohru, Kiyota Naomi, Shimada T, Toyoda Masanori, Fujiwara Y, Nibu Ken-ichi, Komori Takahide, Sasaki Ryohei, Mukohara Toru, Minami Hironobu
    European Society of Medical Oncology, 2012, Oct. 2012, English, European Society of Medical Oncology, Viena, A randomized phase II trial comparing standard pain control with or witout gabapentin for the treatment of pain related radiation-induced mucositis head and neck cancer, International conference
    Poster presentation

  • 前中頭蓋底切除・腹直筋皮弁再建後に再開頭を要した上顎癌2症例
    Doi Kiyoshi, Taniguchi Masaaki, 橋川 和信, Kohmura Eiji, Nibu Ken-ichi
    第24回日本頭蓋底外科学会, Jul. 2012, Japanese, 日本頭蓋底外科学会, 東京, 眼窩・頭蓋底に進展する上顎症例では眼窩内容を含めた前中頭蓋底切除と腹直筋皮弁による再建を行っている。欠損した頭蓋底は筋組織や脂肪組織で充填し、死腔生成が生じないように留意する一方で、過剰な重鎮は硬組織での境界を失った脳に圧迫を加えてしまう危険性を伴うため、その調整が難しい。今回、我々は上顎癌に対する頭蓋底切除・服直筋皮弁再建術後に感染の遷延と脳組織圧迫が生じて再開頭が必要になった症例を経験したので報告する。（症例1：上顎癌rT4aN0M0)動注化学放射線療法後に局所再発し、眼球摘出・前中頭蓋底切除・服直筋皮弁再建を実施した。硬膜と服直筋体との間に死腔が形成され、創部感染を併発した。抗菌療法・洗浄処置を継続するも創部治癒不良で死腔が埋まらず、術後4ヶ月後に頭蓋骨弁除去を行った。（症例2：上顎癌T4aN0M0)手術内容は症例1と同様である。術後3日目に吻, Domestic conference
    Poster presentation

  • 喉頭原発悪性リンパ腫に対する放射線治療の経験
    井上由子, Yoshida Kenji, Miyawaki Daisuke, 西村英輝, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, 岡村篤夫, Saito Miki, Nibu Ken-ichi, Sasaki Ryohei
    日本医学放射線学会関西地方会（第373回レントゲンアーベント）, Jul. 2012, Japanese, 日本医学放射線学会関西地方会（第373回レントゲンアーベント）, 大阪府大阪市（ホテルエルセラーン大阪）, Domestic conference
    Oral presentation

  • 咽頭痛を初発症状とした頸静脈球型値グロムス腫瘍症例
    Hasegawa Shingo, Kohmura Eiji, Nibu Ken-ichi
    第24回日本頭蓋底外科学会, Jul. 2012, Japanese, 日本頭蓋底外科学会, 東京, グロムス腫瘍は鼓室付近の傍神経節より生じる鼓室型と頸静脈球型に大別される。初発症状としては共に拍動性耳鳴や難聴を呈することが多く、次いで頸静脈球型では下位脳神経麻痺を呈することがある。今回、咽頭痛を初発症状に、下位脳神経麻痺を続発した頸静脈球型グロムス腫瘍の症例を経験したので報告する。症例は19歳男性、左咽頭痛を自覚した翌日に左扁桃の腫脹と頭痛が出現し、近医救急外来で投薬を受けた。その後も頭痛と咽頭痛が増悪し、数日で嗄声および嚥下困難も出現したため当院を紹介された。初診時に下位脳神経麻痺（IX,X,XI,XII)を認め、CTで左頸静脈孔に骨破壊を伴う腫瘤陰影を、造影MRIで同部に強く造影される周囲部分とされない中心部分の混在を認めた。血管造影では上行咽頭動脈から腫瘍への栄養血管を認め、頸静脈球型グロムス腫瘍（Fish分類C型）の診断のもと手術を予定し, Domestic conference
    Poster presentation

  • Therapeutic Strategies aimed at Laryngeal Preservation of T1-T3N0 Glottic Laryngeal cancer
    A Harada, Sasaki Ryohei, NS Sulaiman, O Muraoka, Miyawaki Daisuke, Yoshida Kohsuke, H Nishimura, Saito Miki, N Otsuki, Nibu Ken-ichi
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, International conference
    Poster presentation

  • Radiotherapy for Squamous Cell Carcinomas of Oropharynx
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, Y Okamoto, Kiyota Naomi, Saito Miki, N Otsuki, Nibu Ken-ichi, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Purpose: To assess the efficacy radiation therapy for Squamous cell carcinomas of oropharynx at Kobe University Hospital retrospectively.Methods: Between September 1990 and January 2011, 138 patients with Squamous cell carcinomas of the oropharynx were tr, International conference
    Poster presentation

  • Postoperative radiotherapy for the malignant tumors of the parotid gland
    O Muraoka, Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, A Harada, NS Sulaiman, N Otsuki, Nibu Ken-ichi, Y Okamoto, Sasaki Ryohei
    The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium, Jul. 2012, English, 高橋信次記念三次元原体照射国際学会, 広島県（広島国際会議場）, Postoperative radiotherapy for carcinomas of the parotid gland showed favorable local and regional control., International conference
    Poster presentation

  • 頸部リンパ節転移を認めた原発不明悪性黒色腫の2例
    米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 谷本 均, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • 鼻腔悪性黒色腫に対する大線量小分割法放射線治療の経験
    ノル シャズリナ, ビンティ スライマン, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 原田 文, 村岡 修, 岡本欣晃, Doi Kiyoshi, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Poster presentation

  • 頭頸部癌患者における放射線性粘膜炎による疼痛に対するガバペンチンのパイロット・ランダム化比較試験
    片岡 智子, Kiyota Naomi, 島田 貴信, 今村 善宣, Chayahara Naoko, Toyoda Masanori, 船越 洋平, 富岡 秀夫, 藤原 豊, Nibu Ken-ichi, Komori Takahide, 西村 英輝, Sasaki Ryohei, Mukohara Toru, Minami Hironobu
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 松江, 放射線粘膜炎に対するガバペンチンの有用性, Domestic conference
    Oral presentation

  • 当院における中咽頭扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, 村岡 修, ノル シャズリナ, ビンティ スライマン, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 【目的】当院における中咽頭扁平上皮癌の放射線治療成績を遡及的に検討する。【方法】1990年9月から2011年1月までに当院にて中咽頭扁平上皮癌と診断され、放射線治療を施行した138例を対象とした。年齢の中央値は61歳（31-96歳）、男:女=117:21、経過観察期間の中央値は27か月(3-209か月)であった。亜部位は前壁：側壁：後壁：上壁＝39：77：4：18、進展度はT1：T2：T3：T4＝8：71：26：33、N0：N1：N2：N3＝23：21：80：14であった。手術は33例に施行され、化学療法の併用は112例（同時併用91例）、処方線量の中央値は70Gy（50-76.8Gy）であった。【結果】経過観察期間の中央値は27か月(3-209か月)。3年の全生存割合は73％で、無再発生存割合は65％、局所領域制御割合は73％であった。病期別の3年, Domestic conference
    Oral presentation

  • 中咽頭癌に対する同時併用化学放射線療法における経皮内視鏡的胃瘻造設術の有用性についての検討
    高橋 美貴, 竹本 菜保子, 佐野 彩香, 木内 亮平, 松澤 洋子, 佐竹 久美子, 濱田 康弘, 谷本 均, 齋藤 幹, 大月 直樹, 丹生 健一, 宇佐美 眞
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根, Domestic conference
    Oral presentation

  • 多診療科共同で集学的治療を行った頭頸部原発骨軟部肉腫の2例
    島田貴信, Kiyota Naomi, 米澤宏一郎, Doi Kiyoshi, Hasegawa Shingo, 西村英輝, Sasaki Ryohei, Minamikawa Tsutomu, 橋川和信, 田原真一, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 松江, 多診療科連携にて治療した頭頸部肉腫の検討, Domestic conference
    Poster presentation

  • 高齢頭頸部癌患者に対する放射線治療の経験－10年間の検討－
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡 修, 原田 文, ノル シャズリナ, ビンティ スライマン, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 目的 2001年から2010年に神戸大学医学部附属病院において放射線治療が施行された高齢頭頸部癌患者に関する遡及的な検討を行う。対象 75歳以上で根治、術後、及び姑息的局所コントロール目的も含め頸部照射が施行された症例を対象とした。これらについて、患者数の推移や、治療の完遂率等を調査した。結果 症例数は221例であった。うち姑息的局所コントロール目的での照射が46例(21%)であった。年齢は中央値78歳 (75-96歳)で、その内80歳以上は80人で全体の全体の36％であった。男性が164例、女性が58例であった。組織型では扁平上皮癌が最も多く186例、悪性リンパ腫が次いで多く21例、以下癌(分類不能)が6例、腺癌、腺様嚢胞癌が4例ずつであった。原発部位は口腔36例、鼻腔・副鼻腔32例、咽頭57例、喉頭66例、その他が30例と喉頭癌が最も多かった。患, Domestic conference
    Poster presentation

  • 顔面・頭頸部に発生した血管原性腫瘍に対する放射線治療の経験
    Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, Morimoto Koichi, 米澤宏一郎, Ohtsuki Naoki, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Efficacy of radiotherapy to Vascular oriented neoplasm was explained, Domestic conference
    Oral presentation

  • 顎下腺癌に対する放射線療法の経験
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Ohtsuki Naoki, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, 顎下腺癌術後症例に対して放射線療法を施行し、良好な治療成績を得た。, Domestic conference
    Poster presentation

  • T1-T3NO声門癌の喉頭温存を目指した治療方針の検討
    原田 文, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 村岡 修, ノル シャズリナ, ビンティ スライマン, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • AIDS患者の中咽頭扁平上皮癌に対する治療経験
    林 拓二, Fujita Takeshi, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi
    第36回日本頭頸部癌学会, Jun. 2012, Japanese, 日本頭頸部癌学会, 島根県松江市（島根県民会館）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線療法の経験
    村岡 修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田 文, ノル シャズリナ, ビンティ スライマン, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, 耳下腺癌術後症例に対して放射線療法を施行し、良好な局所制御を得た。, Domestic conference
    Others

  • T1-T3NO声門癌の喉頭温存を目指した治療方針の検討
    原田 文, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡 修, ノル シャズリナ, ビンティ スライマン, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第71回日本医学放射線学会総会, Apr. 2012, Japanese, 日本医学放射線学会, 横浜（パシフィコ横浜）, Domestic conference
    Oral presentation

  • Roles and modes of action of nectins and cadherins in the morphogenesis of the olfactory epithelium.
    Katsunuma Sayaka, Togashi Hideru, Nibu Ken-ichi, Takai Yoshimi
    The 11th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery, Dec. 2011, English, 日本耳科学会, 神戸, International conference
    Oral presentation

  • 上顎洞平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, 村岡修, ノルシャズリナ スライマン, 岡本欣晃, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線療法の経験
    村岡修, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, ノルシャズリナ スライマン, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 再建遊離空腸に対する術後(化学)放射線療法の検討
    西村英輝, Yoshida Kenji, Miyawaki Daisuke, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, 副島俊典, 岡本欣晃, Sasaki Ryohei
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • T1(bulky)ｰT3NO喉頭癌の喉頭温存を目指した治療方法の検討
    原田文, Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, ノルシャズリナ スライマン, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki
    第24回日本放射線腫瘍学会, Nov. 2011, Japanese, 日本放射線腫瘍学会, 神戸ポートピアホテル（神戸市）, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 原田文, ノルシャズリナ スライマン, 中山雅央, 上原和之, 赤坂浩亮, 椋本成俊, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第49回日本癌治療学会, Oct. 2011, Japanese, 日本癌治療学会, 名古屋国際会議場（名古屋市）, Domestic conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus: A Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Hasegawa Shingo, Nibu Ken-ichi, Sugimura Kazuro, Sasaki Ryohei
    53rd ASTRO, Oct. 2011, English, ASTRO, マイアミビーチ, アメリカ, International conference
    Oral presentation

  • Combined Modality Therapy Including Radiotherapy for Squamous Cell Carcinomas of Maxillary Sinus - a Retrospective Study
    Miyawaki Daisuke, H Nishimura, Yoshida Kohsuke, O Muraoka, M Nakayama, Uehara Keiichiro, Sugimura Kazuro, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    16ｔｈ ECCO, Sep. 2011, English, ECCO, ストックホルム, ドイツ, International conference
    Oral presentation

  • 粒子線治療後再発に対して側頭骨亜全摘を施行した外耳道癌症例
    Hasegawa Shingo, Kohmura Eiji, 田原 真也, Nibu Ken-ichi
    第23回日本頭蓋底外科学会, Jun. 2011, Japanese, 日本頭蓋底外科学会, 大阪, Domestic conference
    Oral presentation

  • 遊離空腸再建後の高リスク頭頸部癌に対する術後放射線治療の検討
    西村英輝, Sasaki Ryohei, Yoshida Kenji, Miyawaki Daisuke, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Kiyota Naomi, 岡本欣晃, 副島俊典
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 頭頸部皮膚血管肉腫に対するRecursive partitioning analysis(RPA)の検討
    Sasaki Ryohei, 西村英輝, Yoshida Kenji, Miyawaki Daisuke, 村岡修, 橋本直樹, 副島俊典, 藤井 収, Bito Toshinori, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 頭蓋底浸潤を認めた頭頸部癌に対する粒子線治療成績
    Morimoto Koichi, 出水祐介, 寺嶋千貴, 美馬正幸, 藤井 収, 丹羽康江, Miyawaki Daisuke, Sasaki Ryohei, 村上昌雄, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 当科における喉頭機能温存手術の検討
    米澤宏一郎, Morimoto Koichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 当科における顎下腺癌手術症例の検討
    Ohtsuki Naoki, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, 村岡 修, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 切除不能頭頸部癌に対するSequential therapyの安全性に関する後向き研究
    島田貴信, Kiyota Naomi, Ohtsuki Naoki, Nibu Ken-ichi, 西村英輝, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 上顎洞扁平上皮癌に対する放射線治療成績
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 岡本欣晃, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, Nibu Ken-ichi, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 耳下腺癌術後症例に対する放射線治療の経験
    村岡 修, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, 柴田智久, 米澤宏一郎, Morimoto Koichi, Yamashita Daisuke, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 局所進行外耳道扁平上皮癌に対する3剤(TPF)併用化学放射線療法の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡 修, Sasaki Ryohei, Kiyota Naomi, Doi Kiyoshi, Hasegawa Shingo, Nibu Ken-ichi
    第35回日本頭頸部癌学会, Jun. 2011, Japanese, 日本頭頸部癌学会, ウインク愛知（名古屋市）, Domestic conference
    Oral presentation

  • 鼻腔NK/T細胞性リンパ腫に対する放射線治療の経験
    橋本直樹, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 村岡修, 中山雅央, 上原和之, Matsuoka Hiroshi, Nibu Ken-ichi, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 原発不明頸部リンパ節転移に対する治療経験
    村岡修, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, 岡本欣晃, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 局所進行外耳道扁平上皮癌に対する3剤（TPF）併用化学放射線療法の経験
    難波富美子, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 橋本直樹, 村岡修, Sasaki Ryohei, Kiyota Naomi, Hasegawa Shingo, Nibu Ken-ichi
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 橋本直樹, 村岡修, 中山雅央, 上原和之, 菊川久美子, Nibu Ken-ichi, Sasaki Ryohei
    第70回日本医学放射線学会総会, May 2011, Japanese, 日本医学放射線学会, 震災の影響によりWEB開催, Domestic conference
    Oral presentation

  • 局所進行外自動扁平上皮癌に対する3剤（TPF）併用化学放射線療法の経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 村岡修, 橋本直樹, Sasaki Ryohei, Hasegawa Shingo, Kiyota Naomi, Nibu Ken-ichi
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 1・2期下咽頭癌に対する放射線治療成績の検討
    菊川久美子, Miyawaki Daisuke, 西村英輝, Yoshida Kenji, 原田文, 橋本直樹, 村岡修, Nibu Ken-ichi, Sasaki Ryohei, Sugimura Kazuro
    日本放射線腫瘍学会第23回学術大会, Nov. 2010, Japanese, 東京, Domestic conference
    Oral presentation

  • 頭頸部癌化学放射線療法（CRT）への専門的口腔ケア
    西井 美佳, 常之 美貴, 前田 達慶, 多賀 真里子, 米澤 宏一郎, Saito Miki, Nibu Ken-ichi, Komori Takahide
    第16回日本摂食嚥下リハビリテーション学会・学術大会, Sep. 2010, Japanese, 日本摂食嚥下リハビリテーション学会, 新潟, Domestic conference
    Oral presentation

  • Roles of Adhesion Molecules in Mprphogenesis and Regeneration of Olfactory Epithelium
    Katsunuma Sayaka, Togashi Hideru, Nibu Ken-ichi, Takai Yoshimi
    第49回日本鼻科学会総会ならびに学術講演会, Aug. 2010, Japanese, 日本鼻科学会, 札幌, Domestic conference
    Invited oral presentation

  • 原発不明癌頸部リンパ節転移に対する治療経験
    村岡修, Yoshida Kenji, 西村英輝, Miyawaki Daisuke, Sasaki Ryohei, 河辺哲也, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第35回 神戸放射線腫瘍懇話会, Aug. 2010, Japanese, 神戸, Domestic conference
    Oral presentation

  • 嗅神経芽細胞腫に対する粒子線治療成績
    Miyawaki Daisuke, 村上昌雄, 出水祐介, 丹羽康江, 寺嶋千貴, 美馬正幸, 西村英輝, Yoshida Kenji, 河邉哲也, Morimoto Koichi, Nibu Ken-ichi, 菱川良夫, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 放射線治療が施行された喉頭悪性リンパ腫の3例
    上園玄, Yoshida Kenji, 西村英輝, 河辺哲也, Miyawaki Daisuke, Ishihara Takeaki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 同時併用科学放射線療法を行った中咽頭癌患者に対する嚥下リハビリテーションの有用性
    常行美貴, 米澤宏一郎, Morimoto Koichi, Doi Kiyoshi, Hasegawa Shingo, 谷本均, Saito Miki, Ohtsuki Naoki, 清田直臣, Sasaki Ryohei, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当科における耳下腺癌の治療成績
    柴田智久, 米澤宏一郎, Morimoto Koichi, Doi Kiyoshi, Yamashita Daisuke, Hasegawa Shingo, 井上博之, Ohtsuki Naoki, Yoshida Kenji, 西村英輝, Sasaki Ryohei, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当院における頭頚部腺様囊胞腺癌に対する術後放射線治療の遡及的検討
    Ishihara Takeaki, 西村英輝, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, 上園玄, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 当院における中咽頭癌の放射線治療成績
    河辺哲也, Ishihara Takeaki, Miyawaki Daisuke, Yoshida Kenji, 西村英輝, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 超選択的動注法を用いた化学放射線療法後のsalvage手術後に胸鎖関節骨髄炎を来たし治療に難渋した1症例
    米澤宏一郎, Yamashita Daisuke, 松居秀敏, 柴田智久, Nibu Ken-ichi, Sasaki Ryohei, 田原真也
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 原発不明癌頚部リンパ節転移に対する治療経験
    Yoshida Kenji, 西村英輝, Miyawaki Daisuke, 河辺哲也, Sasaki Ryohei, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Kiyota Naomi, 岡本欣晃
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 局所進行頭頸部扁平上皮癌術後再発High-Risk群に対するHigh-dose CDDP+RTの実施可能性試験
    Kiyota Naomi, 田原 信, 門脇 重憲, 岡野 晋, 河島 光彦, 松浦 一登, 小野澤 祐輔, Nibu Ken-ichi, 林 隆一
    第34回日本頭頸部癌学会, Jun. 2010, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 下咽頭癌に対する術後放射線治療の遡及的検討
    西村英輝, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, Nibu Ken-ichi, Saito Miki, Ohtsuki Naoki, Kiyota Naomi, 副島俊典, Sasaki Ryohei
    第34回頭頚部癌学会, Jun. 2010, Japanese, 東京（新宿）, Domestic conference
    Oral presentation

  • 局所進行下咽頭癌に対する術後照射の遡及的検討
    西村英輝, Sasaki Ryohei, Yoshida Kenji, 河辺哲也, Miyawaki Daisuke, Uezono Haruka, Ishihara Takeaki, Nibu Ken-ichi, 副島俊典, Sugimura Kazuro
    第69回日本医学放射線学会, Apr. 2010, Japanese, 横浜, Domestic conference
    Oral presentation

  • ヒト膀胱癌細胞におけるCox-2阻害剤、3剤の攻腫瘍効果の比較検討
    Shirakawa Toshiro, ザイナル アドヒム, 松岡孝幸, Shigemura Katsumi, Nibu Ken-ichi, Kawabata Masato, Fujisawa Masato
    第98回日本泌尿器科学会総会, Apr. 2010, Japanese, 日本泌尿器科学会, 盛岡, Domestic conference
    Oral presentation

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    Yoshida Kohsuke, Sasaki Ryohei, M. Nakabayashi, H. Nishimura, Y. Okamoto, Kawabe T, Hasegawa Shingo, N. Otsuki, Nibu Ken-ichi, Sugimura Kazuro
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • Radiotherapy for Locally Advanced Hypopharyngeal Carcinoma - A Comparison between Definitive (Chemo-) Radiotherapy and Laryngectomy followed by Postoperative Radiotherapy
    H. Nishimura, Sasaki Ryohei, Y. Okamoto, Yoshida Kohsuke, Kawabe T, Nibu Ken-ichi, Ohtsuki Naoki, M. Saitoh, T. Soejima, Sugimura Kazuro
    51th ASTRO, Nov. 2009, English, シカゴ, アメリカ, International conference
    Oral presentation

  • 頭蓋底腫瘍手術時の髄液漏予防と治療について
    Kohmura Eiji, Nibu Ken-ichi, 田原 真也
    第68回日本脳神経外科学会 学術総会, Oct. 2009, Japanese, 日本脳神経外科学会, 東京, Domestic conference
    Oral presentation

  • 聴器扁平上皮癌に対する治療経験
    Yoshida Kenji, 中林 美日, Sasaki Ryohei, 西村 英輝, 河辺 哲也, 岡本 欣晃, Miyawaki Daisuke, 上園 玄, Ishihara Takeaki, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • 小脳橋角部腫瘍における背側橋内高信号の出現と臨床所見の検討
    山本 浩隆, Fujita Atsushi, Hosoda Kokichi, 谷本 均, Nibu Ken-ichi, 青山 信和, 川光 秀昭, Kohmura Eiji
    第68回日本脳神経外科学会 学術総会, Oct. 2009, Japanese, 日本脳神経外科学会, 東京, Domestic conference
    Oral presentation

  • 6大学連携オンコロジーチーム養成プランでのがん専門薬剤師養成コースの活動と現状
    西田 升三, Hirai Midori, 門林 宗男, 福岡 正博, 中川 和彦, 西村 恭昌, 平川 弘聖, 日野 雅之, 工藤 新三, 仲田 文造, 細野 雅子, 松井 徳造, 田中 京子, 高辻 功一, Nibu Ken-ichi, Sasaki Ryohei, Nishimura Yoshihiro, Minami Hironobu, 中野 孝司, 廣田 省三, 長谷川 誠紀, 村川 和重, 一瀬 理加, 鈴木 志津枝, 安藤 悦子
    第47回日本癌治療学会学術大会, Oct. 2009, Japanese, 日本癌治療学会, 横浜, Domestic conference
    Oral presentation

  • Treatment Outcomes of Squamous Cell Carcinoma of External Auditory Canal and Middle Ear
    Yoshida Kohsuke, Sasaki Ryohei, M. Nakabayashi, H. Nishimura, Y. Okamoto, Kawabe T, Hasegawa Shingo, N. Otsuki, Nibu Ken-ichi, Sugimura Kazuro
    15th ECCO, Sep. 2009, English, ベルリン, ドイツ, International conference
    Oral presentation

  • 頭頚部癌に対する集学的治療の取り組み中での放射線生物学の役割
    Sasaki Ryohei, 西村 英輝, Yoshida Kenji, 河邊 哲也, Miyawaki Daisuke, Sugimura Kazuro, Kiyota Naomi, Okuno Tatsuya, Minamikawa Tsutomu, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第48回日本医学放射線学会生物部会学術大会, Jul. 2009, Japanese, 日本医学放射線学会生物部会, 富山, Domestic conference
    Oral presentation

  • 聴器癌に対する外科的治療戦略
    Hasegawa Shingo, Kohmura Eiji, Nibu Ken-ichi
    第21回日本頭蓋底外科学会, Jul. 2009, Japanese, 日本頭蓋底外科学会, 福岡, Domestic conference
    Oral presentation

  • 鼻副鼻腔未分化癌10症例の粒子線治療成績
    Morimoto Koichi, 村上 昌雄, 出水 祐介, Miyawaki Daisuke, 寺嶋 千貴, 有村 健, 丹羽 康江, Sasaki Ryohei, 菱川 良夫, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 頭頸部癌患者に対する化学放射線療法に嚥下リハビリテーションを導入した症例の検討
    常行美貴, Kiyota Naomi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第33回日本頭頸部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 頭頸部がん治療における多職種医療普及のためのサテライト講演会 その成果と課題
    全田貞幹, 大田洋二郎, 本間明宏, Nibu Ken-ichi, 神田亨, 妻木浩美, Kiyota Naomi, 浅井昌大
    第33回日本頭頸部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Poster presentation

  • 当院における下咽頭癌放射線治療の遡及的検討
    西村英輝, Sasaki Ryohei, 岡本欣晃, Yoshida Kenji, 河辺哲也, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, 副島俊典, Sugimura Kazuro
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 聴器扁平上皮癌に対する治療経験
    Yoshida Kenji, 中林 美日, Sasaki Ryohei, 岡本 欣晃, 西村 英輝, 河邊 哲也, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 中咽頭癌に対する放射線治療の遡及的検討
    河邊 哲也, Sasaki Ryohei, 岡本 欣晃, Yoshida Kenji, 西村 英輝, 中川 貴博, Doi Kiyoshi, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 上咽頭癌に対する放射線化学療法の遡及的検討
    Sasaki Ryohei, 河邊 哲也, 西村 英輝, Yoshida Kenji, 岡本 欣晃, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, 福島 俊典, Nibu Ken-ichi
    第33回日本頭頚部癌学会, Jun. 2009, Japanese, 日本頭頸部癌学会, 札幌, Domestic conference
    Oral presentation

  • 当院に於ける中咽頭癌の放射線治療成績
    河邊 哲也, Sasaki Ryohei, Yoshida Kenji, 西村 英輝, 岡本 欣晃, 上原 和之, 中山 雅央, Sugimura Kazuro, Ohtsuki Naoki, Nibu Ken-ichi
    第68回日本医学放射線学会総会, Apr. 2009, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 気管皮膚瘻に対し肋軟骨及びDP皮弁を用いて一期的に再建を行った1例.
    Ejiri Hirotaka, Terashi Hiroto, Sakurai Sayuri, Tahara Shinya, Nibu Ken-ichi
    第52回日本形成外科学会総会・学術集会, Apr. 2009, Japanese, 日本形成外科学会, 横浜, Domestic conference
    Oral presentation

  • Analysis of Complications in Radical Surgery for Malignant Skull Base Tumors
    Kohmura Eiji, Kimura Hidehito, Nibu Ken-ichi, Tahara Shinya
    The 9th Asian-Oceanian International Congress on Skull Base Surgery, Nov. 2008, English, Asian-Oceanian International Congress on Skull Base Surgery, 大阪, 韓国, International conference
    Oral presentation

  • 頭頚部領域の髄外性形質細胞腫６例の放射線治療成績の検討
    Kawabe Tetsuya, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 頭頚部free flap連続250例を対象とした血栓形成危険因子の検討
    Hashikawa Kazunobu, Ejiri Hirotaka, Yokoo Satoshi, Terashi Hiroto, Nibu Ken-ichi, Tahara Shinya
    第26回日本頭蓋顎顔面外科学会学術集会, Oct. 2008, Japanese, 日本頭蓋顎顔面外科学会, 福岡, Domestic conference
    Oral presentation

  • 頭蓋底悪性腫瘍手術における合併症と対策
    Kimura Hidehito, Kohmura Eiji, Sakagami Yoshio, Nibu Ken-ichi, Tahara Shinya
    第67回社団法人日本脳神経外科学会総会, Oct. 2008, Japanese, 社団法人日本脳神経外科学会総会, 岩手, Domestic conference
    Oral presentation

  • 当院に於ける上咽頭癌に対する治療方針の変遷
    Sasaki Ryohei, Okamoto Yoshiaki, Kawabe Tetsuya, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Hasegawa Shingo, Ohtsuki Naoki, Nibu Ken-ichi
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 当院に於ける上咽頭癌に対する治療方針の変遷
    Sasaki Ryohei, Okamoto Yoshiaki, Kawabe Tetsuya, Nishimura Hideki, Yoshida Kenji, Soejima Toshinori, Hasegawa Shingo, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第46回日本癌治療学会総会学術集会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • 早期喉頭癌の局所制御におけるNF-κB発現の検討：他の生物学的マーカーとの比較
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Kawabe Tetsuya, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Soejima Toshinori, Sugimura Kazuro
    日本放射線腫瘍学会第21回学術大会, Oct. 2008, Japanese, 日本放射線腫瘍学会, 札幌, Domestic conference
    Oral presentation

  • 早期喉頭癌(T1-T2N0M0)の局所制御におけるNF-κB発現の検討 他の生物学的マーカーとの比較
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Soejima Toshinori, Nibu Ken-ichi, Sugimura Kazuro
    第46回日本癌治療学会総会学術集会, Oct. 2008, Japanese, 日本癌治療学会, 名古屋, Domestic conference
    Oral presentation

  • Weekly paclitaxel in patients with recurrent or metastatic head and neck cancer: results of two phase II studies.
    Minami Hironobu, Nibu Ken-ichi, Fujii Masahiko
    33rd European Society for Medical Oncology Congress., Sep. 2008, English, 欧州腫瘍内科学会, ストックホルム, スウェーデン, International conference
    Poster presentation

  • 放射線抵抗性の規定因子：NF－Kappa Bの関与とその克服
    Sasaki Ryohei, Yoshida Kenji, Nishimura Hideki, Okamoto Yoshiaki, Soejima Toshinori, Saito Miki, Ohtsuki Naoki, Hayashi Yoshitake, Nibu Ken-ichi, Sugimura Kazuro
    第38回放射線による制癌シンポジウム, Jun. 2008, Japanese, 日本医学放射線学会生物部会, 高知, Domestic conference
    Oral presentation

  • 頭頚部領域の髄外性形質細胞腫の放射線治療の検討
    Sasaki Ryohei, Kawabe Tetsuya, Okamoto Yoshiaki, Nishimura Hideki, Yoshida Kenji, Sugimura Kazuro, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第289回日本医学放射線学会関西地方会, Jun. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 当科における上咽頭癌の治療成績
    Hasegawa Shingo, Okamoto Yoshiaki, Sasaki Ryohei, Nishimura Hideki, Yoshida Kenji, Hirayama Yuji, Nibu Ken-ichi
    第32回日本頭頸部癌学会総会, Jun. 2008, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 神戸大学における悪性腫瘍切除後の遊離皮弁による頭蓋底一次再建
    Hashikawa Kazunobu, Yokoo Satoshi, Terashi Hiroto, Nibu Ken-ichi, Tahara Shinya
    第32回日本頭頸部癌学会・第29回頭頸部手術手技研究会, Jun. 2008, Japanese, 日本頭頸部癌学会・頭頸部手術手技研究会, 東京, Domestic conference
    Oral presentation

  • T1/T2喉頭癌の局所制御におけるNF-kappa B活性の影響について
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第67回日本医学放射線学会総会, Apr. 2008, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    日本医学放射線学会関西地方会, Feb. 2008, English, 日本医学放射線学会, 大阪市, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity for Local Tumor Controllability by Radiotherapy in Patients With T1/T2N0 Laryngeal Cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Sugimura Kazuro, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第288回日本医学放射線学会関西地方会, Feb. 2008, Japanese, 日本医学放射線学会, 大阪, Domestic conference
    Oral presentation

  • 頭頸部がん専門医制度発足に向けて
    Nibu Ken-ichi
    第１８回日本頭頸部外科学会, Jan. 2008, Japanese, 日本頭頸部外科学会, 京都, Domestic conference
    Oral presentation

  • T1/T2喉頭癌の局所制御におけるぬNuclear Factor Kappa B活性の影響についての検討
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, Japanese, 日本放射線腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    第20回日本放射線腫瘍学会, Dec. 2007, English, 日本放射線腫瘍学会, 福岡市, Domestic conference
    Poster presentation

  • 喉頭乳頭腫のよる失声に対し、CO2レーザーにより改善を認めた例
    Morimoto Koichi, Saito Miki, Nibu Ken-ichi
    第５９回日本気管食道科学会総会, Nov. 2007, Japanese, 日本気管食道科学会総会, 群馬, Domestic conference
    Oral presentation

  • 口腔癌広範切除後の早期気管孔切開は必ずしも必要ない―レティナR装着を組み入れた口腔癌広範切除症例の標準治療―．
    Yokoo Satoshi, Furudoi Shungo, Minamikawa Tsutomu, Shibuya Yasuyuki, Umeda Masahiro, Komori Takahide, Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi
    第19回日本口腔科学会近畿地方部会, Nov. 2007, Japanese, 日本口腔科学会, 大阪, Domestic conference
    Oral presentation

  • 頭頸部free flap連続２００例を対象とした血栓形成危険因子の検討～メタボリックシンドロームは危険因子か？～.
    Hashikawa Kazunobu, Yokoo Satoshi, Terashi Hiroto, Nibu Ken-ichi, Tahara Shinya
    第34回日本マイクロサイジャリー学会学術集会, Oct. 2007, Japanese, 日本マイクロサイジャリー学会, 福島, Domestic conference
    Oral presentation

  • 下咽頭癌T1、T2症例の治療成績
    Ohtsuki Naoki, Saito Miki, Sasaki Ryohei, Okamoto Yoshiaki, Nibu Ken-ichi
    第45回日本癌治療学会総会, Oct. 2007, Japanese, 日本癌治療学会, 京都, Domestic conference
    Oral presentation

  • Radiation Therapy for Early Hypopharyngeal Cancer
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori, Sugimura Kazuro
    ASTRO49, Oct. 2007, English, ASTRO, Los Angeles, USA, International conference
    Poster presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    ASTRO49, Oct. 2007, English, ASTRO, Los Angeles, USA, International conference
    Poster presentation

  • 骨髄間質細胞移植による再生医療の可能性
    Nibu Ken-ichi, Doi Kiyoshi, Nishikawa Tasuku
    第４６回日本鼻科学会総会, Sep. 2007, Japanese, 日本鼻科学会, 栃木, Domestic conference
    Oral presentation

  • ヒト線維芽細胞増殖因子（bFGF)点鼻によるマウス嗅上皮の変化に対する免疫組織学的検討
    Nishikawa Tasuku, Nibu Ken-ichi
    第４６回日本鼻科学会総会, Sep. 2007, Japanese, 日本鼻科学会, 栃木, Domestic conference
    Oral presentation

  • Impact of Nuclear Factor Kappa B Activity For Local Tumor Controllability by Radiotherapy in patients with T1/T2N0 laryngeal cancer
    Yoshida Kenji, Sasaki Ryohei, Okamoto Yoshiaki, Nishimura Hideki, Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi, Sugimura Kazuro
    ECCO14, Sep. 2007, English, ECCO, Barcelona, Spain, International conference
    Poster presentation

  • 右中頭蓋窩から側頭下窩へ進展した斜台原発巨大脊索腫に対する１手術例
    Tanaka Kazuhiro, Sakagami Yoshio, Sasayama Takashi, Fujita Atsushi, Kohmura Eiji, Nibu Ken-ichi, Tahara Shinya
    第19回日本頭蓋底外科学会, Jul. 2007, Japanese, 日本頭蓋底外科学会, 東京, Domestic conference
    Oral presentation

  • 頭頸部再建におけるconventional flap，とくに前腕皮弁のreliabilityとversatilityについて.
    Hashikawa Kazunobu, Yokoo Satoshi, Nomura Tadashi, Nibu Ken-ichi, Terashi Hiroto, Tahara Shinya
    第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Public symposium

  • 頭頸部再建Conventional flap ｖｓ.Perforator flapとくに前腕皮弁のrealiabilityとversatility
    Hashikawa Kazunobu, Yokoo Satoshi, Nomura Tadashi, Nibu Ken-ichi, Terashi Hiroto, Tahara Shinya
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    Ohtsuki Naoki, Saito Miki, Tanimoto Hitoshi, Hasegawa Shingo, Ijuin Takahiro, Doi Kiyoshi, Hirayama Yuji, Nibu Ken-ichi, Sasaki Ryohei, Okamoto Yoshiaki
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部癌進行例に対する根治手術後化学放射線療法の検討
    Ohtsuki Naoki, Saito Miki, Tanimoto Hitoshi, Hasegawa Shingo, Ijuin Takahiro, Doi Kiyoshi, Hirayama Yuji, Nibu Ken-ichi, Sasaki Ryohei, Okamoto Yoshiaki
    第31回日本頭頸部癌学会総会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部 free flap 連続200例を対象とした血栓形成危険因子の検討 メタボリックシンドロームは危険因子か？
    Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi, Yokoo Satoshi
    第31回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部free flap連続200例を対象とした血栓形成危険因子の検討 メタボリックシンドロームは危険因子か?.
    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya, Nibu Ken-ichi, Yokoo Satoshi
    第31回日本頭頸部癌学会・第28回頭頸部手術手技研究会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 頭頸部flee flap連続２００例を対象とした血栓形成危険因子の検討 メタボリックシンドロームは危険因子か？
    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya, Nibu Ken-ichi, Yokoo Satoshi
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 当科における聴器癌４１症例の検討
    Hasegawa Shingo, Nibu Ken-ichi, Ishida Haruhiko
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 当院におけるI－II期下咽頭癌に対する根治的放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Sugimura Kazuro, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 当院におけるI-II期下咽頭癌に対する根治的放射線治療の遡及的検討
    Nishimura Hideki, Sasaki Ryohei, Okamoto Yoshiaki, Yoshida Kenji, Sugimura Kazuro, Nibu Ken-ichi, Ohtsuki Naoki, Saito Miki, Soejima Toshinori
    第31回日本頭頸部癌学会総会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 舌癌Ｔ４症例に対する手術治療の検討
    Saito Miki, Nibu Ken-ichi
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 口腔癌の頸部リンパ節転移についての検討 いわゆる飛び石転移について
    Hirayama Yuji, Nibu Ken-ichi, Doi Kiyoshi, Shimizu Kenichiro
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • アンケートを用いた頸部郭清術後機能多施設共同研究
    Nibu Ken-ichi
    第３１回日本頭頸部癌学会, Jun. 2007, Japanese, 日本頭頸部癌学会, 横浜, Domestic conference
    Oral presentation

  • 嗅覚研究・臨床の進歩 嗅神経細胞の再生医療
    Nibu Ken-ichi
    第１０８回日本耳鼻咽喉科学会, May 2007, Japanese, 日本耳鼻咽喉科学会, 金沢, Domestic conference
    Oral presentation

  • 鼻性視神経症と鑑別を要したMiller－Fisher症候群の一例
    Inoue Hiroyuki, Ishida Haruhiko, Nibu Ken-ichi
    第１０８回日本耳鼻咽喉科学会, May 2007, Japanese, 日本耳鼻咽喉科学会, 金沢, Domestic conference
    Oral presentation

  • 加齢に伴うマウス嗅上皮の変性の進行 病変の分布と細胞動態の解析
    Nibu Ken-ichi
    第１０８回日本耳鼻咽喉科学会, May 2007, Japanese, 日本耳鼻咽喉科学会, 金沢, Domestic conference
    Oral presentation

  • １期／２期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第６６回日本医学放射線学会, Apr. 2007, Japanese, 日本放射線学会, 横浜, Domestic conference
    Oral presentation

  • 遊離空調による食道・口腔底再建術後に嚥下困難をきたした１例
    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi
    第５０回日本形成外科学会, Apr. 2007, Japanese, 日本形成外科学会, 東京, Domestic conference
    Oral presentation

  • 口腔癌広範切除後の早期気管孔閉鎖は必ずしも必要でない―レティナ装着を組み入れた口腔癌広範切除症例の標準治療―．
    Yokoo Satoshi, Furudoi Shungo, Minamikawa Tsutomu, Shibuya Yasuyuki, Umeda Masahiro, Komori Takahide, Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi
    第61回日本口腔科学会学術集会, Apr. 2007, Japanese, 日本口腔科学会, 神戸, Domestic conference
    Oral presentation

  • レテイナ装着を組み入れた口腔癌広範切除症例の標準治療.
    Yokoo Satoshi, Furudoi Shungo, Minamikawa Tsutomu, Shibuya Yasuyuki, Umeda Masahiro, Komori Takahide, Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi
    第61回日本口腔科学会総会, Apr. 2007, Japanese, 日本口腔科学会, 神戸, Domestic conference
    Public symposium

  • I/II期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Soejima Toshinori, Nibu Ken-ichi, Sugimura Kazuro
    第66回日本医学放射線学会総会, Apr. 2007, Japanese, 日本医学放射線学会, 横浜市, Domestic conference
    Poster presentation

  • 1期/2期喉頭癌に対する根治的放射線治療成績
    Yoshida Kenji, Sasaki Ryohei, Nishimura Hideki, Okamoto Yoshiaki, Sugimura Kazuro, Nibu Ken-ichi
    第66回日本医学放射線学会総会, Apr. 2007, Japanese, 日本医学放射線学会, 横浜, Domestic conference
    Oral presentation

  • 嚥下機能回復を目的とした舌広範切除後の標準治療―遊離腹直筋皮弁をスタンダードフラップとした再建の効果―．
    Yokoo Satoshi, Furudoi Shungo, Minamikawa Tsutomu, Shibuya Yasuyuki, Umeda Masahiro, Komori Takahide, Hashikawa Kazunobu, Tahara Shinya, Nibu Ken-ichi
    第25回日本口腔腫瘍学会総会ワークショップ, Feb. 2007, Japanese, 日本口腔腫瘍学会, 名古屋, Domestic conference
    Oral presentation

  • 遊離空腸採取後の吻合部を先進部とする腸重積の一例
    KAMIGAKI TAKASHI, KURODA DAISUKE, Nibu Ken-ichi, KURODA YOSHIKAZU
    第68回日本臨床外科学会総会, Nov. 2006, Japanese, 日本臨床外科学会総会, 広島, Domestic conference
    Oral presentation

  • パネルディスカッション７ 頭頸部癌の治療戦略―最近の動向―頭頸部癌に対する遺伝子治療
    Nibu Ken-ichi
    第４４回日本癌治療学会総会, Oct. 2006, Japanese, 日本癌治療学会, 東京, Domestic conference
    Public symposium

  • シンポジウム 難治性喉頭疾患の手術—痙攣性発声障害—
    Nibu Ken-ichi
    第５８回気管食道科学会, Oct. 2006, Japanese, 日本気管食道科学会, 札幌, Domestic conference
    Public symposium

  • 悪性頚動脈小体腫瘍の一症例
    TANIMOTO HITOSHI, Nibu Ken-ichi
    第153回日耳鼻兵庫県地方部会, Jul. 2006, Japanese, 日本耳鼻咽喉科学会, 神戸, Domestic conference
    Oral presentation

  • シンポジウム５ 頭蓋底悪性腫瘍の治療戦略：切除手術と放射線治療 頭頸部癌に対する頭蓋底手術―予後と合併症ー
    Nibu Ken-ichi
    第１８回日本頭蓋底外科学会, Jul. 2006, Japanese, 日本頭蓋底外科学会, 名古屋, Domestic conference
    Public symposium

  • 頭頸部扁平上皮癌におけるp63 isoformの発現と臨床病理学的因子の検討
    Ohtsuki Naoki, Nibu Ken-ichi
    第30回日本頭頚部癌学会, Jun. 2006, Japanese, 日本頭頚部癌学会, 大阪, Domestic conference
    Oral presentation

  • 耳下腺癌症例の治療方針
    Ohtsuki Naoki, Nibu Ken-ichi
    第30回日本頭頚部癌学会, Jun. 2006, Japanese, 日本頭頚部癌学会, 大阪, Domestic conference
    Oral presentation

  • 甲状腺Epithelioid Angiosarcomaの１例
    Ohtsuki Naoki, Nibu Ken-ichi
    第30回日本頭頚部癌学会, Jun. 2006, Japanese, 日本頭頚部癌学会, 大阪, Domestic conference
    Oral presentation

  • 下咽頭癌に対するレーザー切徐術の検討
    Saito Miki, Ohtsuki Naoki, Nibu Ken-ichi
    第30回日本頭頚部癌学会, Jun. 2006, Japanese, 日本頭頚部癌学会, 大阪, Domestic conference
    Oral presentation

  • シンポジウム５ 下咽頭癌と喉頭癌の治療を今改めて考える喉頭癌・下咽頭癌における喉頭温存と音声再建
    Nibu Ken-ichi
    第30回日本頭頚部癌学会, Jun. 2006, Japanese, 日本頭頚部癌学会, 大阪, Domestic conference
    Public symposium

  • FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY OF HUMAN OLFACTION
    Nibu Ken-ichi
    The 25th International Symposium oｆ Infection and Allergy of the Nose, Jun. 2006, English, European Rhinologic Society (ERS), International Symposium on Infection & Allergy of the Nose (ISIAN), Tampere, International conference
    Oral presentation

  • BCL-2 EXPRESSION MEDIATED BY CRE/LOXP SYSTEM IN OLFACTORY EPITHELIUM
    DOI KIYOSHI, Nibu Ken-ichi
    The 25th International Symposium oｆ Infection and Allergy of the Nose, Jun. 2006, English, European Rhinologic Society (ERS), International Symposium on Infection & Allergy of the Nose (ISIAN), Tampere, International conference
    Oral presentation

  • 臨床セミナー６ 高齢者の耳鼻咽喉科食事からみた高齢者の耳鼻咽喉科
    Nibu Ken-ichi
    第107回日本耳鼻咽喉科学会総会, May 2006, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Public symposium

  • B7-1遺伝子導入腫瘍細胞を用いた頭頸部悪性腫瘍の免疫遺伝子治療
    Ishida Haruhiko, Nibu Ken-ichi
    第107回日本耳鼻咽喉科学会総, May 2006, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 当科における喉頭肉芽腫の検討
    Nibu Ken-ichi
    第１８回日本喉頭科学会, Apr. 2006, Japanese, 日本喉頭科学会, 熊本, Domestic conference
    Oral presentation

  • Fez2, which facitates KLK6 serine protease, is essential for development of the mouse olfactory system.
    WATANABE,Yoshihisa, Inoue K, Okuyama-Yamamoto A, Nakatani J, NIBU, Kenichi, TERASHIMA, Toshio, Kondoh G, Takeda J, Takumi T
    The 35th Annual Meeting of Society of Neuroscience, Nov. 2005, English, Society of Neuroscience, ワシントンD.C., International conference
    Poster presentation

  • 下咽頭癌のリンパ節転移についての検討 いわゆる飛び石転移について
    HIRAYAMA, Yuji, 斎藤 幹, TANIMOTO, Hitoshi, 田中 博紀, SHIMIZU, Kenichiro, NIBU, Kenichi, AMATSU, Mutsuo, 木西 實, MOHRI, Mitsuhiro
    第１５０回日耳鼻兵庫県地方部会, Jul. 2005, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • 喉頭下咽頭早期癌の診断と治療 当科における下咽頭癌の治療成績
    越智 尚樹, 斎藤 幹, TANIMOTO, Hitoshi, 田中 博紀, SHIMIZU, Kenichiro, MOHRI, Mitsuhiro, 木西 實, AMATSU, Mutsuo, NIBU, Kenichi
    第２９回日本頭頸部癌学会, Jun. 2005, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 気管空腸瘻（TJシャント）による音声再建：再建結果の評価と適応の検討
    橋川 和信, TAHARA, Shinya, 斎藤 幹, NIBU, Kenichi, 木西 實
    第29回日本頭頸部癌学会学術集会, Jun. 2005, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • 下咽頭癌のリンパ節転移についての検討 いわゆる飛び石転移について
    HIRAYAMA, Yuji, 斎藤 幹, TANIMOTO, Hitoshi, 田中 博紀, SHIMIZU, Kenichiro, NIBU, Kenichi, AMATSU, Mutsuo, 木西 實, MOHRI, Mitsuhiro
    第２９回日本頭頸部癌学会, Jun. 2005, Japanese, 日本頭頸部癌学会, 東京, Domestic conference
    Oral presentation

  • ヒト喉頭粘膜の肥満細胞phenotypeについて
    ISHIDA, Haruhiko, NIBU, Kenichi, AMATSU, Mutsuo
    第１０６回日本耳鼻咽喉科学会, May 2005, Japanese, 日本耳鼻咽喉科学会総会, 大阪, Domestic conference
    Oral presentation

  • Cre酵素組み換えアデノウイルスとbcl-２組み換えアデノウィルスとの共感染による嗅上皮への遺伝子導入の試み
    DOI, Kiyoshi, TERASHIMA, Toshio, 岡戸 晴雄, NIBU, Kenichi
    第１０６回日本耳鼻咽喉科学会, May 2005, Japanese, 日本耳鼻咽喉科学会, 大阪, Domestic conference
    Oral presentation

  • 舌・中咽頭広範囲切除症例の嚥下機能維持のための工夫
    井上 玲奈, YOKOO, Satoshi, SHUNGO, Furudoi, UMEDA, Masahiro, KOMORI, Takahide, 橋川 和信, 加藤 智恵理, NIBU, Kenichi
    第59回日本口腔科学会総会, Apr. 2005, Japanese, 日本口腔科学会, 徳島, Domestic conference
    Oral presentation

  • 扁桃滴状乾癬の１例
    堅田 敬太, TANIMOTO, Hitoshi, NISHIGORI, Chikako, NIBU, Kenichi
    第１４８回日耳鼻兵庫県地方部会, Dec. 2004, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • 当科における反回神経麻痺症例の検討
    干谷 安彦, 斎藤 幹, NIBU, Kenichi
    第１４８回日耳鼻兵庫県地方部会, Dec. 2004, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • ストレプトマイシン誘発耳鳴患者で見つかった新しいミトコンドリアDNA変異
    TANIMOTO, Hitoshi, NIBU, Kenichi, NISHIO, Hisahide, MATSUO, Masafumi
    第145回日本耳鼻咽喉科学会兵庫県地方部会, Dec. 2004, Japanese, 日本耳鼻咽喉科学会兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • ストレプトマイシン難聴者の遺伝カウンセリング症例
    TANIMOTO, Hitoshi, NIBU, Kenichi, NISHIO, Hisahide, MATSUO, Masafumi
    第１４８回日耳鼻兵庫県地方部会, Dec. 2004, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • 側頭骨軟骨芽細胞腫の１症例
    米澤 宏一郎, 田中 博紀, ISHIDA, Haruhiko, NIBU, Kenichi, 牧野 邦彦
    第１４回日本耳科学会, Oct. 2004, Japanese, 日本聴覚医学会, 京都, Domestic conference
    Oral presentation

  • 鼻腔放射菌による鼻石の１症例
    桐月 涼世, INOUE, Hiroyuki, ISHIDA, Haruhiko, NIBU, Kenichi
    第４３回日本鼻科学会, Sep. 2004, Japanese, 日本鼻科学会, 東京, Domestic conference
    Oral presentation

  • 前頭洞から眼窩に存在したコレステリン肉芽腫の一例
    金城 東和, 田中 博紀, ISHIDA, Haruhiko, NIBU, Kenichi
    第４３回日本鼻科学会, Sep. 2004, Japanese, 日本鼻科学会, 東京, Domestic conference
    Oral presentation

  • 神経栄養因子の嗅神経細胞再生への治療効果の検討
    DOI, Kiyoshi, ISHIDA, Haruhiko, NIBU, Kenichi
    第４３回日本鼻科学会, Sep. 2004, Japanese, 日本鼻科学会, 東京, Domestic conference
    Oral presentation

  • 嗅神経細胞におけるアデノウイルスベクターの発現
    DOI, Kiyoshi, NIBU, Kenichi, ISHIDA, Haruhiko
    第１４７回日耳鼻兵庫県地方部会, Jul. 2004, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • 鼻副鼻腔、および眼窩腫瘍症例の頭蓋底手術における鼻副鼻腔の処理について
    ISHIDA, Haruhiko, NIBU, Kenichi, KOUMURA, Eiji, TAHARA, Shinya
    第１６回日本頭蓋底外科学会, Jul. 2004, Japanese, 日本頭蓋底外科学会, 横浜, Domestic conference
    Oral presentation

  • 前頭洞から眼窩に存在したコレステリン肉芽腫の一例
    金城 東和, 田中 博紀, ISHIDA, Haruhiko, NIBU, Kenichi
    第１４７回日耳鼻兵庫県地方部会, Jul. 2004, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • 前頭蓋底合併切除を要したSyringomatous carcinoma
    HASEGAWA, Shingo, KOUMURA, Eiji, NIBU, Kenichi
    第１６回日本頭蓋底外科学会, Jul. 2004, Japanese, 日本頭蓋底外科学会, 横浜, Domestic conference
    Oral presentation

  • Retropharyngeal node matastasis of thyroid papillary carcinoma.
    Otsuki N, NISHIKAWA,Tetsuo, Iwae S, NIBU, Kenichi
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • Quality of life after neck dessection.
    INOUE,Hiroyuki, SHIMIZU,Kenichiro, Otsuki N, NIBU, Kenichi
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • Long-term follow up study of voice rehabilitation after total laryngectomy using Amatsu operation.
    SAITO, Miki, Otsuki N, AMATSU,Mutsuo, NIBU, Kenichi
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • Impact of in situ hybridization hor EBER-1 on the prognosis of nasopharygeal carcinoma.
    Nakao K, NIBU, Kenichi, Sugasawa M
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • Distribution of metasteatic lymph nodes in oropharyngeal calcinoma and its impact on profnosis.
    SHIMIZU,Kenichiro, INOUE,Hiroyuki, Otsuki N, Mkino K, NIBU, Kenichi
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • COX-2臓器特異性プロモーターと組み込んだ増殖型アデノウイルスベクターによる頭頸部扁平上皮癌に対する治療法の検討
    田中 博紀, Zhujun Zhang, 白川 利明, 後藤 彰暢, NIBU, Kenichi
    第１４７回日耳鼻兵庫県地方部会, Jul. 2004, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • A conditional replication-compitent adenoviral vector to target the COX-2 expressing vector cells
    TANAKA, Hiroshi, Zhang Z, SHIRAKAWA, Taku, GOTOH,Akinobu, NIBU, Kenichi
    第６回国際頭頸部癌会議, Jul. 2004, English, 国際頭頸部癌会議, 神戸, International conference
    Oral presentation

  • 頸部郭清術後機能評価～斉川班術後機能アンケートによる～
    INOUE Hiroyuki, OHTSUKI, Naoki, NIBU, Kenichi, 藤井 隆, 鬼塚 哲郎, 斉川 雅久
    第２８回日本頭頸部腫瘍学会, Jun. 2004, Japanese, 日本頭頸部腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • チタンメッシュと前腕皮弁を用いた上顎癌切除後の眼窩底再建－長期観察症例の検討－
    橋川 和信, TAHARA, Shinya, ISHIDA, Haruhiko, NIBU, Kenichi, 高木 正, NAKAHARA,Minoru, 花垣 博史, 山王 俊明
    第28回日本頭頸部腫瘍学会, Jun. 2004, Japanese, 日本頭頸部腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • チタンメッシュと前腕皮弁を用いた上顎癌切除後の眼窩底再建ー長期観察症例の検討ー
    橋川 和信, TAHARA, Shinya, ISHIDA, Haruhiko, 高木 正, NAKAHARA,Minoru, 山王 俊明, 花垣 博史, NIBU, Kenichi
    第２８回日本頭頸部腫瘍学会, Jun. 2004, Japanese, 日本頭頸部腫瘍学会, 福岡, Domestic conference
    Oral presentation

  • 嚥下機能回復手術と再建外科の併用による舌広範切除症例の喉摘からの回避 -神戸大学における嚥下機能維持のための取り組み-
    井上 玲奈, YOKOO, Satoshi, 石田 佳毅, SHUNGO, Furudoi, UMEDA, Masahiro, KOMORI, Takahide, 橋川 和信, TAHARA, Shinya, 井上 智絵里, NIBU, Kenichi
    第58回日本口腔科学会総会, May 2004, Japanese, 日本口腔科学会, 横浜, Domestic conference
    Oral presentation

  • 嗅神経細胞におけるアデノウイルスベクターの発現
    DOI, Kiyoshi, NIBU, Kenichi, ISHIDA, Haruhiko
    第１０５回日本耳鼻咽喉科学会, May 2004, Japanese, 日本耳鼻咽喉科学会, 広島, Domestic conference
    Oral presentation

  • 増殖性アデノウイルスによる頭頸部扁平上皮癌株に対する治療法の検討
    田中 博紀, Zhujun Zhang, 白川 利明, 後藤 彰暢, NIBU, Kenichi
    第１０５回日本耳鼻咽喉科学会, May 2004, Japanese, 日本耳鼻咽喉科学会, 広島, Domestic conference
    Oral presentation

  • 唾液腺腫瘍の術前診断に関する検討ー穿刺吸引細胞診と術中迅速診についてー
    OHTSUKI, Naoki, KANOMATA, Naoki, INOUE, Hiroyuki, 斎藤 幹, FUJISHIMA, Sadahiro, TANIMOTO, Hitoshi, SHIMIZU, Kenichiro, ISHIDA, Haruhiko, NIBU, Kenichi
    第１４６回日耳鼻兵庫県地方部会, Mar. 2004, Japanese, 日耳鼻兵庫県地方部会, 尼崎, Domestic conference
    Oral presentation

  • 重傷壊死性筋膜炎の１例
    益田 葉子, OHTSUKI, Naoki, 浦長瀬 昌弘, FUJISHIMA, Sadahiro, NIBU, Kenichi
    第１４６回日耳鼻兵庫県地方部会, Mar. 2004, Japanese, 日耳鼻兵庫県地方部会, 尼崎, Domestic conference
    Oral presentation

  • 額下腺膨大細胞腫の一例
    奥西 真帆, TANIMOTO, Hitoshi, SHIMIZU, Kenichiro, OHTSUKI, Naoki, KANOMATA, Naoki, NIBU, Kenichi
    第１４６回日耳鼻兵庫県地方部会, Mar. 2004, Japanese, 日耳鼻兵庫県地方部会, 尼崎, Domestic conference
    Oral presentation

  • 内視鏡下経鼻的アプローチにより摘出した翼口蓋窩腫瘍例
    HASEGAWA, Shingo, 堅田 敬太, ISHIDA, Haruhiko, NIBU, Kenichi
    第１４回日本頭頸部外科学会, Jan. 2004, Japanese, 日本頭頸部外科学会, 東京, Domestic conference
    Oral presentation

  • 耳下腺・甲状腺手術における神経モニタリング装置（NIM-ResponseTM)の使用経験
    INOUE, Hiroyuki, SAKAMOTO, Koichi, 中山 正子, NIBU, Kenichi
    第１４回日本頭頸部外科学会, Jan. 2004, Japanese, 日本頭頸部外科学会, 東京, Domestic conference
    Oral presentation

  • アレルギー性鼻炎に対する粘膜下下鼻甲介骨切除・固有層凝固術の長期成績
    ISHIDA, Haruhiko, FUJISHIMA, Sadahiro, 堅田 敬太, NIBU, Kenichi
    第１４回日本頭頸部外科学会, Jan. 2004, Japanese, 日本頭頸部外科学会, 東京, Domestic conference
    Oral presentation

  • 側頭骨軟骨芽細胞腫の１例
    米澤 宏一郎, 田中 博紀, ISHIDA, Haruhiko, NIBU, Kenichi, 牧野 邦彦
    第145回日耳鼻兵庫県地方部会, Dec. 2003, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • ストレプトマイシン誘発耳鳴日本人患者で見つかった新しいミトコンドリア遺伝子変異
    TANIMOTO, Hitoshi, NISHIO, Hisahide, MATSUO, Masafumi, NIBU, Kenichi
    第145回日耳鼻兵庫県地方部会, Dec. 2003, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • ステノン管由来洞管内乳頭腫の一例
    金城 東和, TANIMOTO, Hitoshi, 米澤 宏一郎, OHTSUKI, Naoki, NIBU, Kenichi
    第145回日耳鼻兵庫県地方部会, Dec. 2003, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • Benign symmetrical lipomatosis(BSL)の治療経過
    浦長瀬 昌宏, FUJISHIMA, Sadahiro, OHTSUKI, Naoki, 堅田 敬太, NIBU, Kenichi
    第145回日耳鼻兵庫県地方部会, Dec. 2003, Japanese, 日耳鼻兵庫県地方部会, 西宮, Domestic conference
    Oral presentation

  • 同一の大胸筋皮弁にて2回の再建を施行した頬部未分化癌の一例 -内側胸筋神経温存の有用性-
    馬殿 逸子, YOKOO, Satoshi, MINAMIKAWA,Tsutomu, SHUNGO, Furudoi, UMEDA, Masahiro, KOMORI, Takahide, 野村 正, TERASHI, Hiroto, NIBU, Kenichi
    第１5回日本口腔科学会近畿地方部会, Nov. 2003, Japanese, 日本口腔科学会, 京都, Domestic conference
    Oral presentation

  • 前頭洞epidermoid cyst の１症例
    SHIMIZU, Kenichiro, ISHIDA, Haruhiko, NIBU, Kenichi
    第４３回日本鼻科学会, Oct. 2003, Japanese, 日本鼻科学会, 東京, Domestic conference
    Oral presentation

  • ルビエールリンパ節に転移を認めた甲状腺乳頭癌の2例
    OHTSUKI, Naoki, NIBU, Kenichi
    第３６回甲状腺外科研究会, Oct. 2003, Japanese, 甲状腺外科研究会, 京都, Domestic conference
    Oral presentation

  • 老化促進モデルマウスSAM-P1の嗅上皮
    DOI, Kiyoshi, NIBU, Kenichi
    第２１回頭頸部自律神経研究会, Aug. 2003, Japanese, 頭頸部自律神経研究会, 大阪, Domestic conference
    Oral presentation

  • 痙攣性発生障害に対する手術経験
    SAITO, Miki, 井上 智恵理, NIBU, Kenichi, 渡辺 雄介
    第144回日耳鼻兵庫県地方部会, Jul. 2003, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • 鼻副鼻腔生検で確定診断の得られた顕微鏡的多発血管炎の１症例
    古閑 紀雄, 細見 慶和, NIBU, Kenichi
    第６５回耳鼻咽喉科臨床学会, Jul. 2003, Japanese, 耳鼻咽喉科臨床学会, 京都, Domestic conference
    Oral presentation

  • 頭頸部悪性腫瘍の診断治療効果判定へのFDG-PETの臨床応用
    INOUE, Hiroyuki, ISHIDA, Haruhiko, NIBU, Kenichi, SAKAMOTO, Koichi
    第８回神戸頭頸部腫瘍懇話会, Jul. 2003, Japanese, 神戸頭頸部腫瘍懇話会, 神戸, Domestic conference
    Oral presentation

  • 当科における深頸部膿瘍３０症例の検討
    吉岡 大介, HASEGAWA, Shingo, SHIMIZU, Kenichiro, OHTSUKI, Naoki, OHTSU, Masahide, ISHIDA, Haruhiko, NIBU, Kenichi
    第６５回耳鼻咽喉科臨床学会, Jul. 2003, Japanese, 耳鼻咽喉科臨床学会, 京都, Domestic conference
    Oral presentation

  • 前頭洞epidermoid cyst の１症例
    堅田 敬太, SHIMIZU, Kenichiro, ISHIDA, Haruhiko, NIBU, Kenichi
    第144回日耳鼻兵庫県地方部会, Jul. 2003, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • スギ花粉症の咽喉頭症状について（2002年スギ花粉飛散期における調査）
    ISHIDA, Haruhiko, NIBU, Kenichi, 細見 慶和, 奥窪 明子, 木村 真美, 安井 理絵, 吉田 尚史
    第144回日耳鼻兵庫県地方部会, Jul. 2003, Japanese, 日耳鼻兵庫県地方部会, 神戸, Domestic conference
    Oral presentation

  • 頸部滑膜肉腫の１例
    越智 尚樹, 魚住 真樹, TANIMOTO, Hitoshi, NIBU, Kenichi
    頭頸部分子腫瘍学研究会, Jun. 2003, Japanese, 頭頸部分子腫瘍学研究会, 金沢, Domestic conference
    Oral presentation

  • 頸部Hibernoma（冬眠腫）の一例
    宮村 卓, TERASHI, Hiroto, 牧口 貴哉, TAHARA, Shinya, NIBU, Kenichi
    第80回日本形成外科学会関西支部学術集会, Jun. 2003, Japanese, 日本形成外科学会関西支部, 神戸, Domestic conference
    Oral presentation

  • 鼻腔腺癌に対する炭素線治療の一治験例
    OHTSU, Masahide, ISHIDA, Haruhiko, NIBU, Kenichi, 香川 一史, 村上 昌雄, 菱川 良夫
    第２７回日本頭頸部腫瘍学会, Jun. 2003, Japanese, 日本頭頸部腫瘍学会, 金沢, Domestic conference
    Oral presentation

  • 当科におけるWarthin腫瘍症例の臨床的検討
    森本 浩一, OHTSUKI, Naoki, ISHIDA, Haruhiko, NIBU, Kenichi
    第２７回日本頭頸部腫瘍学会, Jun. 2003, Japanese, 日本頭頸部腫瘍学会, 金沢, Domestic conference
    Oral presentation

  • 中頭蓋底に存在した髄膜脳瘤の１例
    西川 匡, ISHIDA, Haruhiko, NIBU, Kenichi
    第１５回日本頭蓋底外科学会, Jun. 2003, Japanese, 日本頭蓋底外科学会, 東京, Domestic conference
    Oral presentation

  • 中咽頭前壁型および上壁型扁平上皮癌症例の検討
    SHIMIZU, Kenichiro, NIBU, Kenichi, INOUE, Hiroyuki, DOI, Kiyoshi, AMATSU, Mutsuo, 牧野 邦彦
    第２７回日本頭頸部腫瘍学会, Jun. 2003, Japanese, 日本頭頸部腫瘍学会, 金沢, Domestic conference
    Oral presentation

  • 耳下腺初発と考えられた悪性リンパ腫症例の検討
    李 佳奈, OHTSUKI, Naoki, OHTSU, Masahide, 木西 實, NIBU, Kenichi
    第２７回日本頭頸部腫瘍学会, Jun. 2003, Japanese, 日本頭頸部腫瘍学会, 金沢, Domestic conference
    Oral presentation

  • 顎下部に発生した脂肪腫の１例
    原 聡, IJUIN, Takahiro, ISHIDA, Haruhiko, NIBU, Kenichi
    第２７回日本頭頸部腫瘍学会, Jun. 2003, Japanese, 日本頭頸部腫瘍学会, 金沢, Domestic conference
    Oral presentation

  • 滲出性中耳炎における中耳貯留液と上咽頭粘膜の細菌学的検討
    濱本 由記子, 後藤 友佳子, 下屋 聡子, 中上 佳美, 香山 智佳子, NIBU, Kenichi
    第１０４回日本耳鼻咽喉科学会, May 2003, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 頭頸部悪性腫瘍の診断治療効果判定へのFDG-PETの臨床応用
    INOUE, Hiroyuki, SAKAMOTO, Koichi, ISHIDA, Haruhiko, NIBU, Kenichi, 坂本 摂, 千田 道雄
    第１０４回日本耳鼻咽喉科学会, May 2003, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • 術前寒栓術が奏功した鼓室型グロームス腫瘍例
    増井 紗矢香, HASEGAWA, Shingo, MOHRI, Mitsuhiro, NIBU, Kenichi
    第１０４回日本耳鼻咽喉科学会, May 2003, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • Osler病の４症例
    ISHIDA, Haruhiko, NIBU, Kenichi, 干谷 安彦
    第１０４回日本耳鼻咽喉科学会, May 2003, Japanese, 日本耳鼻咽喉科学会, 東京, Domestic conference
    Oral presentation

  • スギ花粉症の咽喉頭症状について（2002年スギ花粉飛散期における調査）
    ISHIDA, Haruhiko, NIBU, Kenichi, 細見 慶和, 奥窪 明子, 安井 理絵, 吉田 尚史
    台１５回日本喉頭科学会, Apr. 2003, Japanese, 日本喉頭科学会, 秋田, Domestic conference
    Oral presentation

■ Research Themes
  • 免疫チェックポイント阻害剤と遺伝子治療の併用による頭頸部癌に対する治療法の開発
    丹生 健一, 井之口 豪, 上原 奈津美
    日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, Apr. 2022 - Mar. 2026

  • Molecular pathological analysis of salivary gland carcinomas promoting personalized medicine: A large-scale multicenter study
    稲垣 宏, 加納 里志, 中黒 匡人, 奥村 嘉英, 岩井 大, 丹生 健一, 草深 公秀, 櫻井 一生, 山元 英崇, 河田 了, 村瀬 貴幸, 田口 健一, 正木 彩子, 羽藤 直人, 多田 雄一郎, 川北 大介, 花井 信広, 大上 研二, 長尾 徹, 長尾 俊孝
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Nagoya City University, Apr. 2021 - Mar. 2024
    唾液腺癌は稀な腫瘍であるが、われわれは多施設共同研究組織を構築し、これまでに多数の症例を収集した。2021年度は以下の研究を行い、論文発表を行った。 1. 粘表皮癌は唾液腺癌の中で最も頻度の高い腫瘍であるが、その組織学的多様性は十分明らかになっていない。我々は粘表皮癌117例を亜型分類したところ、Classical (74%), Clear/oncocytic (8%), Warthin-like (3%), Clear cell (3%), Oncocytic (2%), Spindle (2%), Sclerosing (2%), Mucinous (3%), Central (2%)であることを明らかにした。Ciliated, Mucoacinar, High-grade transformationは認められなかった(Histopathology, 2021, PMID: 34657306）。 2. 粘表皮癌に次いで頻度の高い腫瘍である腺様嚢胞癌は、組織学的に、充実性腫瘍成分により悪性度を推定することが多いが、それを正確に判定することはしばしば困難である。われわれは腺様嚢胞癌195例を臨床病理学的に検討し、充実性腫瘍成分の短径が客観的な悪性度指標であることを明らかにした（Cancer Sci, 2021, PMID: 33377247）。 3. 粘表皮癌は稀に胸腺に発生するが、その詳細は明らかではない。われわれは国際共同研究を行い、胸腺粘表皮癌の臨床病理学的、分子病理学的特徴を系統的に解析した。興味深いことに、CRTC1-MAML2融合遺伝子は56％の症例に認められ、患者の予後良好と関連した（Am J Surg Pathol, 2022, PMID: 35319525）。

  • Development of multidisciplinary treatment by cytokine signal inhibitor molecule gene transfer for head and neck cancer
    大月 直樹, 丹生 健一
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kindai University, Apr. 2019 - Mar. 2023
    頭頸部癌の中でも甲状腺癌は生物学的悪性度の低い分化癌から極めて悪性度の高い未分化癌に移行することが知られている。これまで分化癌である甲状腺乳頭癌 と未分化癌との分子生物学的な比較検討がなされてきたが、未分化転化に至るメカニズムは未解明である。 昨年度までの研究では、分化癌として手術を施行した症例で、組織学的検査により未分化癌と判明した偶発型未分化癌の関連遺伝子およびSOCS3、STAT3、IL-6など JAK-STAT経路に関連する遺伝子のコードするタンパクについて免疫組織染色により検討を行った。その結果、すべての例でBRAFの発現が分化癌成分および未分化 癌成分の両者で見られたのに対してp53は未分化癌成分のみで発現が認められた。SOCS3などJAK-STAT経路に関連する遺伝子については、免疫組織染色により75％ の甲状腺乳頭癌でSOCS3のタンパク発現が認められたが、未分化癌では発現が認められなかった。このことは、SOCS3の発現低下によって未分化癌への転化が引き 起こされているという仮説を支持している。 この仮説をもとに、甲状腺未分化癌の細胞株を用 いたin vitro実験を行ってきた。その結果、アデノウイルスベクターによるSOCS3導入により、細胞株におけるSOCS3蛋白の発現は亢進する一方で、甲状腺未分化癌細胞の増殖は抑制された。 今年度はSTAT3、IL-6などJAK-STAT経路に関連する遺伝子について検討している。今後は増殖抑制のメカニズムを解明するとともに、in vivo研究へつなげる予定である。

  • Combined effects of co-stimulatory molecule gene transfer and radiotherapy on immune checkpoint inhibitors
    Ken-ichi Nibu
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, Apr. 2019 - Mar. 2022
    In our previous study, we reported that gene transfer of the B7 molecule (CD80) into a mouse squamous cell carcinoma model efficiently amplified tumor-specific CTLs and had a growth inhibitory effect not only on tumor cells expressing the B7 molecule (CD 80) but also on non-transfected tumor cells. In this study, we examined the combined effects of immune checkpoint inhibitors and gene transfer of the co-stimulatory molecule B7 molecule (CD 80) using a mouse squamous cell carcinoma model. The combination of both treatment strategies resulted in almost complete disappearance of tumors transplanted into mice and a significant combined effect.

  • Molecular pathological analysis of salivary gland carcinomas focusing on personalized medicine: A large-scale multicenter study
    Inagaki Hiroshi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Nagoya City University, Apr. 2018 - Mar. 2021
    Salivary gland carcinomas are rare tumors, and a large number of these carcinoma cases were collected through multicenter joint research and clinical pathological analysis was performed. We clarified that certain types of benign tumors are difficult to distinguish from adenoid cystic carcinoma, and proposed a novel grading system of adenoid cystic carcinoma. We reported that the prognosis of patients with specific fusion-positive mucoepidermoid carcinoma is extremely good, and that in these patients, postoperative radiotherapy can be omitted. It is hoped that these studies will promote molecular pathology of salivary gland carcinomas and that it will be directly and indirectly applied to the stratified and individualized treatment for patients with salivary gland carcinomas.

  • 丹生 健一
    科学研究費補助金／基盤研究(B), Apr. 2016 - Mar. 2019, Principal investigator
    Competitive research funding

  • 大月 直樹
    学術研究助成基金助成金／基盤研究(C), Apr. 2016 - Mar. 2019
    Competitive research funding

  • 小野 玲
    学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018
    Competitive research funding

  • 丹生 健一
    学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2017, Principal investigator
    Competitive research funding

  • （AMED）頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    丹生 健一
    国立研究開発法人日本医療研究開発機構, 革新的がん医療実用化研究事業, 2017, Principal investigator
    Competitive research funding

  • （AMED）HPV関連中咽頭癌の治療最適化に関する研究
    丹生 健一
    学校法人近畿大学, 革新的がん医療実用化研究事業, 2017, Principal investigator
    Competitive research funding

  • 大月 直樹
    学術研究助成基金助成金／基盤研究(C), Apr. 2013 - Mar. 2016
    Competitive research funding

  • 土井 清司
    学術研究助成基金助成金／基盤研究(C), Apr. 2013 - Mar. 2016
    Competitive research funding

  • （AMED）鼻副鼻腔悪性腫瘍に対する内視鏡下頭蓋底手術の標準化を目指した多施設共同研究
    丹生 健一
    革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

  • （AMED）頭頸部癌全国症例登録システムの構築と臓器温存治療のエビデンス創出
    丹生 健一
    国立研究開発法人日本医療研究開発機構, 革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

  • （AMED）上顎洞癌の治療最適化に関する研究/上顎洞癌の治療最適化に関する研究「ガイドラインへの反映」
    丹生 健一
    革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

  • （AMED）喉頭・下咽頭癌における最適な喉頭温存治療法に関する研究/頭頸部悪性腫瘍全国登録システムを利用したエビデンス創出の体制整備
    丹生 健一
    革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

  • （AMED）HPV関連中咽頭癌の治療最適化に関する研究/頭頸部癌登録システムの再構築とガイドライン作成
    丹生 健一
    革新的がん医療実用化研究事業, 2016, Principal investigator
    Competitive research funding

  • 丹生 健一
    学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2013 - Mar. 2015, Principal investigator
    Competitive research funding

  • 丹生 健一
    科学研究費補助金／基盤研究(B), Apr. 2012 - Mar. 2015, Principal investigator
    Competitive research funding

  • Taste sensation and QOL in oropharyngeal cancer patients treated by chemo-radiotherapy: A prospective, multicenter clinical study
    MATSUZAWA HIROKO, USAMI Makoto, KATAYAMA Megumi, WAKITA Kumiko, NIBU Kenichi, SAITOU Miki, YAMANE Hideo, IGUCHI Hiroyoshi, YADA Mamiko, FUKUDA Atsuko, KATAYAMA Osamu, AKAHANI Shirou, TAKAHASHI Miki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka City University, 2011 - 2013
    Chemo-radiotherapy (CRT)is highly efficacious in the treatment of oropharyngeal cancer patients, but is accompanied by a high incidence of adverse events. In this study, we followed adverse events and changes in the QOL status associated with CRT over a long term. The results revealed that adverse events occurred at a radiation dose of 20 Gy or higher and they did not disappear even 9 months after the CRT completion. The body weight of the patients also decreased substantially.Patients' QOL was found not to recover after CRT within the studied period. These findings confirm that active interventions on the patients are required even after the CRT completion.

  • SAITO Miki, NIBU Kenichi, OTSUKI Naoki, YONEZAWA Kouichirou
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2011 - 2013
    Aged persons, who complained of suffocated by water, are subjected to this study. The subjects are ordered to execute vocal function exercise for 8 week. Questionnaire about their swallowing function, fiberoptic examination, stroboscopy, aerodynamic study and acoustic study are performed before the vocal function exercise. After this vocal rehabilitation, swallowing function and vocal function are evaluated. Though fiberoptic findings and stroboscopic findings show now change before and after the rehabilitation, acoustic study and aerodynamic study show improvement of their vocal function. According to the questionnaire, frequency of the cough during their meal decreased. As the vocal function exercise is very simple rehabilitation and easy to continue, even the aged persons can carry out easily.
    Competitive research funding

  • Research of the efficacy of particle therapy against head and neck cancer
    MORIMOTO Koichi, NIBU Ken-ichi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2011 - 2012
    Proton and carbon ion radiotherapy resulted in satisfactory local control in patients with locally advanced unresectable primary head and neck cancers invading the skull base. ACC and ONB were favorable pathologic types. Although severe late toxicities were observed in considerable patients, most of the late toxicities were acceptable when the extension of the cancer was taken into account.

  • NIBU Ken-ichi, OTSUKI Naoki, SHIRAKAWA Toshiro
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2009 - 2011, Principal investigator
    While multimodal treatments have been performed for the treatment of head and neck cancers, the prognoses of the patients with advanced head and neck cancer are still poor. The estimated survival rates of those patients are around 30%. New strategies for the treatment for head and neck cancer are desirable. To address this issue, we developed the midkine promoter-driven replication-selective adenoviral vector containing siRNA for EGFR or VEGF. With this adenoviral vector, synergistic effect of oncolytic adenovirus and inhibition of oncogene via RNA interference is effect.
    Competitive research funding

  • 丹生 健一
    学術研究助成基金助成金／挑戦的萌芽研究, 2011, Principal investigator
    Competitive research funding

  • COX promoter-based replication-selective adenoviral vector for head and neck cancer
    NAKAGAWA Takahiro, NIBU Ken-ichi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2009 - 2010
    Significant growth inhibition effect of COX-2 on head and neck squamous cell carcinoma was observed in proportion to the concentration of COX-2. Significant growth inhibition effect of sjRNA against E6 and/or E7 gene of HPV on HPV-associated head and neck squamous cell carcinoma was observed not only in vitro but also in vivo.

  • OTSUKI Naoki, NIBU Kenichi, SHIRAKAWA Toshiro
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2008 - 2010
    Introduction of HPV16 E6/E7 siRNA might be a potentially potent and specific approach, to inhibit proliferation and induce apoptosis of HNSCC containing HPV16 cell lines. For clinical we are currently preparing to test the effects of HPV16 E6/E7 siRNA on xenograft of HNSCC containing HPV16 cell lines
    Competitive research funding

  • OKAMOTO Yoshiaki, SASAKI Ryohei, SUGIMURA Kazuro, NIBU Kenichi, YOSHIDA Suguru, MIZUSHINA Yoshiyuki, NISHIMURA Hideki
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2007 - 2008
    レドックスを可変させる物質としてVitamin K3を用いてフリーラジカルを発生させ、癌細胞と正常細胞に与える影響に関して検討した。Vitamin K3は少量ではミトコンドリア呼吸機能を可変させ、多量では急激な細胞死を来す結果も得た。一方で類似構造を持ち、食品にも含まれるVitamin K1はレドックスをあまり可変させず、癌細胞、正常細胞ともに細胞死を誘導しない。また同様に類似構造を持つVitamin K2では一部の癌細胞では細胞死を誘導した。
    Competitive research funding

  • NIBU Ken-ichi, TERASHIMA Toshio, DOI Kiyoshi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2006 - 2008, Principal investigator
    嗅神経細胞の障害による嗅覚障害の新たな治療法開発を目指して、嗅神経細胞の再生における分子機構の解明を進めるとともに、様々な再生医療の可能性を検討した。分子機構解明の研究では、DNA マイクロアレイを用いて、嗅上皮の再生過程における遺伝子発現を解析。新規遺伝子Fezf1 が嗅上皮内での嗅神経細胞の配列に重要であることを示した。治療法についての研究では、アデノウイルスベクターが嗅神経細胞のみならず、嗅球への遺伝子産物導入にも有効であることを示し、Cre/loxP システムを用いて、Bcl2 遺伝子の導入により、嗅神経細胞のアポトーシスを抑制できることを示した。更に、bFGF の鼻腔内局所投与により、嗅神経細胞の前駆細胞である球状基底細胞の増殖をみること、骨髄間質幹細胞を鼻腔内に直接投与することにより、嗅上皮内に移植することができることを示した。
    Competitive research funding

  • 丹生 健一
    日本学術振興会, 科学研究費補助金／萌芽研究, 萌芽研究, 神戸大学, 2006 - 2007, Principal investigator
    【目的】我々はこれまでにCOX-2をプロモーターとした増殖制限型アデノウイルスベクターAdCOX2がCOX-2を高発現する頭頸部扁平上皮癌に対してoncolyticな作用による抗腫瘍効果を示すことをin vitroならびにin vivoで証明した。本年度はCOX-2高発現扁平上皮癌培養細胞株を対象に、COX-2の発現そのものの抑制により腫瘍の増殖や浸潤、転移を抑制することを目指し、COX-2阻害剤であるエトドラクを用いて検討した。更に、新たな増殖制限型アデノウイルスベクターを用いた頭頸部癌遺伝子治療の可能性の検討を開始した。 【方法】 1.COX-2高発現扁平上皮癌培養細胞株を濃度の異なるエトドラクを含んだ培養液を用いて培養し、その増殖抑制効果を検討した。 2.中華人民共和国で開発された増殖制限型アデノウイルスベクターH101を入手し、マウス扁平上皮癌モデルを用いて頭頸部癌に対する抗腫瘍効果の検討を開始した。 【結果】 1.エトドラクは濃度依存性に腫瘍の増殖を抑制することを確認した。 2.共同研究者からH101を入手し、現在ウイルスの調整中である。 【考察】 1.エトドラクによるCOX-2の発現抑制により、腫瘍の増殖を抑制することが確認できた。現在、その機序について検討中である。 2.H101による扁平上皮癌への治療效果をマウスモデルを用いて研究を続けていきたい。
    Competitive research funding

  • 厚生科研：頭顎部がんのリンパ節転移に対する標準的手術法の確立に関する研究
    斉川 雅久
    2007
    Competitive research funding

  • OKAMOTO Yoshiaki, SUGIMURA Kazuro, NIBU Kenichi, SASAKI Ryohei, KAWASAKI Ryota, OTA Yosuke
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2005 - 2006
    Significance of AKT in the radioresistant mechanism has not been clarified. In this study, Free radical mediated AKT activation and NF-kappa B activation were closely related to the radioresistance in both normal and malignant cells. Especially, Pelicano and Sasaki have reported that mitochondrial respiratory function communicated with AKT activation through free radical, and the communication led to the invasiveness of the tumor or chemosensitivity. Demizu and Okamoto have reported that effectiveness of cisplatin-based concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma, and clinical outcomes of the treatment as a preliminary report. In the present study, we have found there are certain percentage of patients who experienced their poor outcomes. Moreover, we are now investigating that the relationships between resistance to the anticancer treatment and the AKT activation, as well as p53, NF-kappa B. Ejima and Okamoto have reported that outcomes of MALT lymphoma of the orbita in the journal of Radiotherapy and Oncology. In the study, prognostic factors and adverse effects were clarified from the analysis, in the same time. For this disease, prognostic factors have not been determined. Therefore, candidates for molecular mechanisms of radioresistance, such as AKT, p53 BCL-10, were also assessed. Those results were now preparing for another submission. Thus, the significance of AKT in the radioresistant mechanism were investigated in the multiple situation. In vitro study, and clinical investigation were performed, leading to the fact that AKT was one of the important candidate for molecular mechanisms of intracellular radioresistance.
    Competitive research funding

  • 石田 春彦
    科学研究費補助金／基盤研究(C), 2006
    Competitive research funding

  • 頭顎部がんのリンパ節転移に対する標準的手術法の確立に関する研究
    斉川 雅久
    2006
    Competitive research funding

  • 丹生 健一
    日本学術振興会, 科学研究費補助金／萌芽研究, 萌芽研究, 神戸大学, 2005 - 2005, Principal investigator
    背景:現在、嗅覚障害は一般にステロイド剤の局所投与を中心として治療がなされているが、その作用機序は未だ明らかではなく、感冒罹患後や外傷など嗅上皮より中枢の軸索や嗅球の障害が原因と考えられる嗅覚障害や、加齢に伴う嗅覚障害に対しては有効な治療法はない。本研究は「神経栄養因子の遺伝子を組み込んだアデノウイルスベクターによる新たな嗅覚障害の治療法開発」を目指して計画された。 方法:BDNF遺伝子またはGDNF遺伝子を組み込んだアデノウイルスベクターを鼻腔よりマウス嗅上皮へ投与し、1〜4週間後にマウス鼻腔ならびに嗅球を一塊に採取。嗅神経細胞における各遺伝子の発現を遺伝子産生蛋白に対する免疫染色により確認した。更に、アデノウイルスベクター投与後1週間後に嗅球除去によるアポトーシスを誘発し、嗅神経細胞に発現させたDNFまたはGDNFにより、嗅神経細胞のアポトーシスを抑制することが可能か否か検討した。 結果:BDNFまたはGDNFの発現はアデノウイルスベクター投与数日後から嗅上皮内に確認された。しかしながら嗅球除去モデルでは嗅神経細胞のアポトーシス抑制効果はみられなかった。 考察:アデノウイルスベクターに神経栄養因子の遺伝子を組み込むことにより、目的の遺伝子を嗅神経細胞に発現させることに成功した。しかしながら、今回用いたモデルで嗅神経細胞のアポトーシスを回避することはできなかった。嗅神経細胞の維持には他の神経栄養因子も関与している可能性があり、更なる研究が必要である。
    Competitive research funding

  • 頭頸部がんの頸部リンパ節転移に対する標準的手術法の確立に関する研究
    斉川 雅久
    2005
    Competitive research funding

  • 丹生 健一
    科学研究費補助金／基盤研究(B), 2005, Principal investigator
    Competitive research funding

  • The roles of ret/PTC fusion genes in thyroid papillary carcinoma
    NIBU Ken-ichi, SHIMIZU Ken-ichiro, OHTSU Masanide, ISHIDA Haruhiko
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), 1999 - 2002
    Background: The activation of ret proto-oncogene, through chromosomal translocation, is reported as unique to papillary thyroid carcinomas. However, the prevalence of RET/PTC activation in papillary carcinoma reported was variable and the clinical relevance of RET/PTC rearrangements in papillary carcinomas is still controversial. Methods: To investigate the roles of ret rearrangement in the carcinogenesis of papillary thyroid carcinoma, we have studied ret activation and p53 overexpression in various thyroid lesions of Japanese population by immunohistochemical technique. Results: Ret activation and p53 overexpression were studied in 40 papillary carcinomas, 5 poorly differentiated carcinomas, 1 undifferentiated carcinoma, 2 medullary carcinoma, 2 follicular carcinomas, 19 follicular adenomas. RET activation was observed in 12 out of 40 papillary carcinomas, while no immunoreactivity of ret was detected in other lesions. P53 overexpression was observed in only one of 40 papillary carcinomas. Conclusion: The prevalence of RET/PTC activation in papillary carcinoma among Japanese population was higher than previous reports. Immunohistochemistry is proved as a useful tool to detect RET/PTC activation in thyroid tumors. RET rearrangements are restricted to a well-differentiated papillary carcinoma, suggesting that RET/PTC positive papillary carcinomas do not progress to undifferentiated carcinoma.

  • 下咽頭癌に対する放射線治療におけるp53遺伝子とWAF1/CIP1遺伝子の役割-
    丹生 健一
    日本学術振興会, 科学研究費助成事業, 奨励研究(A), 東京大学, 1996 - 1996
    最近、放射線や抗癌剤の治療において、p53およびp21(WAF1/CIP1)遺伝子の経路を介した細胞死(アポトーシス)が関与していることが明らかになってきた。臨床的にも正常型のp53を有する腫瘍では放射線治療によりアポトーシスが見られるが、変異をもつ腫瘍細胞ではアポトーシスがみられないことが報告されて注目されている。今回我々は、梨状陥凹型の下咽頭扁平上皮癌未治療新鮮例57例の治療前生検標本についてP53遺伝子ならびにP21遺伝子の発現を免疫組織学的に観察し、放射線の治療効果との関係を検討した。治療は原則として40Gy照射後、下咽頭喉頭全摘術および頚部郭清術を行った。原発巣の手術標本が保存されていた55例中8例においてviableな細胞が全く残存していなかった(PCR)。p53陽性20例中2例が、p53陰性35例中6例がPCRであった。一方、p21陽性16例中3例が、p21陰性39例中5例がPCRであった。いずれも統計学的有意差は認められなかった。また、初診時リンパ節転移が認められた42例中8例において摘出されたリンパ節にviableな腫瘍細胞は全く残存していなかった(NCR).p53陽性15例中5例が、p53陰性27例中3例がNCRであった(p<0.1)。一方、p21陽性13例中4例が、p21陰性29例中4例がNCRであった(NS)。リンパ節転移に対する放射線治療の効果にp53遺伝子が関与している可能性が示唆され、さらに症例数を増やして検討する必要があると考えられた。

  • 下咽頭癌におけるp53癌抑制遺伝子とWAF1/CIP1遺伝子の役割
    丹生 健一
    日本学術振興会, 科学研究費助成事業, 奨励研究(A), 東京大学, 1995 - 1995
    最近p53遺伝子により転写促進され、細胞周期のG1期からS期への移行を促すcyclin-dependent-kinaseを阻害する蛋白としてp21(WAF1/CIP1)が発見され、p53遺伝子の機能解明の糸口として注目されている。今回我々は、梨状陥凹型の下咽頭扁平上皮癌未治療新鮮齢57例を対象とし、p53遺伝子の機能をP53蛋白ならびにP21蛋白を免疫組織学的に観察することにより調べ,従来の臨床的および病理組織学的な事項と比較検討して,予後因子としての可能性とその意義を検討した。p53蛋白の免疫染色をおこなった57例中,p53陽性群は21例,p53陰性群は36例であった。5年生存率はp53陽性群で59%,p53陰性群では28%,とp53陽性群の予後は有意に良好であった(p=0.01)。p53の過剰発現の有無と,分化度,T分類,N分類,Stage分類との相関は認められなかったが,病理組織学的頸部リンパ節転移数と有意な相関が認められ(p<0.02)、p53陽性腫瘍は多発リンパ節転移を起こしにくいと考えられた。p53陽性群に対してp21(WAF1/CIP1)蛋白の免疫染色をおこなった21例中6例において腫瘍細胞の核に明らかな濃染が認められた。p53陽性例中p21(WAF1/CIP1)陽性の6例と,陰性の15例の5年生存率はそれぞれ100%,44%と,有意差は認められなかったが(p=0.068),p21(WAF1/CIP1)陽性群の予後が良好な傾向が認められた。下咽頭癌においてp21(WAF1/CIP1)蛋白の発現の有無はp53蛋白の発現と独立した予後因子となる可能性が示唆された。

  • Role of p53 gene mutations in the multi-step car cinogenesis of head and neck squamous cell car cinomas
    TANAKA Tadashi, NIBU Ken-Ichi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), University of Tokyo, 1994 - 1995
    Toinvestigate the correlation between patients' smoking history and the frequency of p53 gene mutations in squamous cell car cinomas of the head and neck, 18 DNA samples from head and neck car cinoma specimens were investigated for the presence of p53 gene mutations by polymerase chain reaction (PCR)-single strand confor mation polymor phisms (SSCP) analysis followed by direct DNA sequencing. Five mutations of the p53 gene were identified (28%) in 18 tumor samples. One sample showed a small deletion in exon 5 and four samples showed a point mutation in exon 5, three of these mutations were G to Atransitions at codon 175 and one was a T to C transition at codon 143. Of 5 patients with p53 gene mutations, 4 had a history of heavy smoking, whereas only 3 of 13 patients without p53 gene mutations had such a history. This p53 gene mutation pattern differs from those reported in esophageal and lung cancers, two other tobacco-associated neoplasms, in which G : C to T : A transversions are the most frequent substitution. Findings suggest that alteration in p53 gene function may be common in patients with head and neck cancers with a history of heavy smoking, however, mutagens or mutagenic processes that differ from those in lung and esophageal cancers may beinvolved in the generation of p53 gene mutations in head and neck cancers.

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