SEARCH
Search Details
HARA HitomiGraduate School of Medicine / Faculty of Medical SciencesAssociate Professor
Research activity information
■ Award- Oct. 2023 第7回日本リハビリテーション医学会秋季学術集会, Young Investigator Award (YIA), 骨転移患者に対するリハビリテーション治療効果 傾向スコアマッチングを用いた検討
- Sep. 2021 日本整形外科学会 基礎学術集会, Best Poster Award, 乳癌骨転移による骨破壊に寄与するmiRNAの検討
- Oct. 2020 第4回日本リハビリテーション医学会秋季学術集会, Young Investigator Award (YIA), 骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討
- Feb. 2019 整形外科集談会 京阪神地方会, 京阪神集談会Best Paper Award, 膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した一例Others
- Oct. 2014 APOA(Asia Pacific Orthopaedic Association; アジア太平洋整形外科学会), 第18回APOA(Asia Pacific Orthopaedic Association; アジア太平洋整形外科学会)No.1 Poster Presentation Award (Best Poster Award), YM155, A Novel Small Molecule Survivin Suppressant, Suppresses Tumor Progression With Increased Mitochondrial Apoptosis In Human Malignant Fibrous Histiocytoma CellsInternational society
- Granulocyte-colony stimulating factor (G-CSF) is commonly used to reduce neutropenia-related complications following chemotherapy. It is a glycoprotein that stimulates the production of granulocytes [white blood cells (WBCs) in the bone marrow. In the present study, the case of a 59-year-old man is presented who received chemotherapy (eribulin) for liver metastases from sacral chordoma and subsequently developed acute aortitis after the administration of G-CSF. Grade 3 neutropenia occurred on day eight of the fifth chemotherapy cycle, and pegfilgrastim was administered on day nine. A total of 3 days after pegfilgrastim administration, the patient developed a fever that persisted for 6 days. He visited our hospital on day 18 with abdominal pain and elevated WBC count and C-reactive protein levels. Febrile neutropenia was suspected, and antibiotics were administered. However, both blood and urinalysis cultures returned negative results, and antibiotics were ineffective. Contrast-enhanced computed tomography revealed a thickened wall of the brachiocephalic artery and abdominal aorta, consistent with aortitis. After discontinuing the antibiotics, the patient was monitored closely without further treatment. His condition improved within a few days; therefore, it was concluded that aortitis was induced by G-CSF.Oct. 2025, Biomedical reports, 23(4) (4), 161 - 161, English, International magazineScientific journal
- (公社)日本整形外科学会, Sep. 2025, 日本整形外科学会雑誌, 99(8) (8), S1612 - S1612, Japanese
- Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60-100) to 90 (IQR: 70-100), and EQ-5D improved from 0.444 (IQR: 0.282-0.608) to 0.608 (IQR: 0.533-0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies.Aug. 2025, Journal of bone oncology, 53, 100703 - 100703, English, International magazineScientific journal
- Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were destroyed. This study suggests the potential of BNCT as a new option for the treatment of human ES.Aug. 2025, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 222, 111846 - 111846, English, International magazineScientific journal
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1373 - S1373, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1409 - S1409, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1411 - S1411, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1453 - S1453, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1455 - S1455, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1462 - S1462, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1515 - S1515, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1409 - S1409, Japanese
- (公社)日本整形外科学会, Jun. 2025, 日本整形外科学会雑誌, 99(6) (6), S1455 - S1455, Japanese
- Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.Mar. 2025, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 217, 111603 - 111603, English, International magazineScientific journal
- Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.Feb. 2025, Oncology reports, 53(2) (2), English, International magazineScientific journal
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 68 - 68, Japaneseがんロコモ対策の現状と課題 四肢骨転移に対する治療の現状と課題
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 92 - 92, Japanese整形外科における女性医師キャリア形成の現状と課題 自身のキャリア形成の現状と課題 1度手術を手放した私が再び手術を学ぶチャンスをつかむまで
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese膝関節内に巨大腫瘤を形成し腱滑膜巨細胞腫との鑑別を要した滑膜軟骨腫症の一例
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 269 - 269, Japanese肘部管症候群を合併した右肘滑膜軟骨腫症の一例
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討
- (一社)中部日本整形外科災害外科学会, Oct. 2024, 中部日本整形外科災害外科学会雑誌, 68(秋季学会) (秋季学会), 320 - 320, JapaneseEwing肉腫におけるslow-cycling-cellsの特性の探索 次世代シーケンス解析を用いた検討
- (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1964 - S1964, Japanese網羅的遺伝子解析を用いたEwing肉腫におけるslow-cycling-cellsの特性の探索
- (公社)日本整形外科学会, Sep. 2024, 日本整形外科学会雑誌, 98(8) (8), S1967 - S1967, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討
- BACKGROUND: Few studies have compared the clinical outcomes of patients with pelvic bone sarcomas treated surgically and those treated with particle beam therapy. This is a multicenter retrospective cohort study which compared the clinical outcomes of patients with pelvic bone sarcoma who underwent surgical treatment and particle beam therapy in Japan. METHODS: A total of 116 patients with pelvic bone sarcoma treated at 19 specialized sarcoma centers in Japan were included in this study. Fifty-seven patients underwent surgery (surgery group), and 59 patients underwent particle beam therapy (particle beam group; carbon-ion radiotherapy: 55 patients, proton: four patients). RESULTS: The median age at primary tumor diagnosis was 52 years in the surgery group and 66 years in the particle beam group (P < 0.001), and the median tumor size was 9 cm in the surgery group and 8 cm in the particle beam group (P = 0.091). Overall survival (OS), local control (LC), and metastasis-free survival (MFS) rates were evaluated using the Kaplan-Meier method and compared among 116 patients with bone sarcoma (surgery group, 57 patients; particle beam group, 59 patients). After propensity score matching, the 3-year OS, LC, and MFS rates were 82.9% (95% confidence interval [CI], 60.5-93.2%), 66.0% (95% CI, 43.3-81.3%), and 78.4% (95% CI, 55.5-90.5%), respectively, in the surgery group and 64.9% (95% CI, 41.7-80.8%), 86.4% (95% CI, 63.3-95.4%), and 62.6% (95% CI, 38.5-79.4%), respectively, in the particle beam group. In chordoma patients, only surgery was significantly correlated with worse LC in the univariate analysis. CONCLUSIONS: The groups had no significant differences in the OS, LC, and MFS rates. Among the patients with chordomas, the 3-year LC rate in the particle beam group was significantly higher than in the surgery group.Jul. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 30(3) (3), 523 - 528, English, Domestic magazineScientific journal
- (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1506 - S1506, JapaneseCompress型インプラントによる腫瘍用人工関節置換術例の検討
- (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1527 - S1527, JapaneseEwing肉腫におけるslow-cycling-cellsの特性の探索
- (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1528 - S1528, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索 新規開発骨肉腫がん幹細胞様細胞を用いた検討
- (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1599 - S1599, Japanese転移性骨腫瘍に対するデノスマブ長期投与中止後の調査
- (公社)日本整形外科学会, Jun. 2024, 日本整形外科学会雑誌, 98(6) (6), S1674 - S1674, Japanese術前に陽子線を照射した粘液型脂肪肉腫の2例
- Background and Objectives: Changes in activities of daily living (ADL) and quality of life (QOL) of patients with bone metastasis who underwent surgical treatment through Bone Metastasis Cancer Boards (BMCBs), a recent multidisciplinary approach for managing bone metastases, have been reported; however, no reports exist on patients who undergo conservative treatment. In this study, we aimed to evaluate these patients' ADL and QOL and examine the factors influencing changes in these parameters. Materials and Methods: We retrospectively reviewed 200 patients with bone metastases who underwent conservative therapy through BMCBs between 2013 and 2021. A reassessment was conducted within 2-8 weeks after the initial assessment. Patients' background and changes in performance status (PS), Barthel Index (BI), EuroQol five-dimension (EQ-5D) scores, and Numerical Rating Scale (NRS) scores were initially assessed. Furthermore, we categorized patients into two groups based on improvements or deteriorations in ADL and QOL and performed comparative analyses. Results: Significant improvements in EQ-5D (0.57 ± 0.02 versus [vs.] 0.64 ± 0.02), NRS max (5.21 ± 0.24 vs. 3.56 ± 0.21), and NRS average (2.98 ± 0.18 vs. 1.85 ± 0.13) scores were observed between the initial assessment and reassessment (all p < 0.001). PS (1.84 ± 0.08 vs. 1.72 ± 0.08) and BI (83.15 ± 1.68 vs. 84.42 ± 1.73) also showed improvements (p = 0.06, and 0.054, respectively). In addition, spinal cord paralysis (odds ratio [OR]: 3.69, p = 0.049; OR: 8.42, p < 0.001), chemotherapy (OR: 0.43, p = 0.02; OR: 0.25, p = 0.007), and NRS average scores (OR: 0.38, p = 0.02; OR: 0.14, p < 0.001) were independent factors associated with ADL and QOL. Conclusions: Patients with bone metastases who underwent conservative treatment through BMCBs exhibited an increase in QOL without a decline in ADL. The presence of spinal cord paralysis, absence of chemotherapy, and poor pain control were associated with a higher risk of deterioration in ADL and QOL.May 2024, Medicina (Kaunas, Lithuania), 60(6) (6), English, International magazineScientific journal
- (公社)日本リハビリテーション医学会, May 2024, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S449 - S449, Japanese保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- (公社)日本リハビリテーション医学会, May 2024, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S449 - S449, Japanese保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 175 - 175, Japanese小児脛骨に発症したBCG骨髄炎の1例
- (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S530 - S530, Japanese新しい骨転移診療ガイドラインにおける整形外科の関わりと意義 骨転移診断ガイドラインから見た骨転移に対する薬物療法
- (一社)中部日本整形外科災害外科学会, Mar. 2024, 中部日本整形外科災害外科学会雑誌, 67(2) (2), 169 - 170, JapaneseA case of femoral gossypiboma showing enlargement associated with chronic expanding hematoma after 30 years of follow-up
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, Mar. 2024, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 67(2) (2), 167 - 168, Japanese
- (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S530 - S530, Japanese
- BACKGROUND/AIM: Despite the well-publicized clinical outcomes after unplanned excision (UE) and re-excision (re-excision) in patients with soft-tissue sarcoma (STS), there is little information about the real-life referral patterns for UE, such as patient profile, details of procedures, and subsequent management after UE. We aimed to investigate the characteristics of patients with UE who were referred to sarcoma-specific centers. PATIENTS AND METHODS: Between May 2022 and June 2023, we registered 97 patients who underwent UE and were referred to sarcoma-specific centers in Japan. We excluded those with well-differentiated liposarcomas and dermatofibrosarcoma protuberances. We investigated the details of UE and additional treatment after UE. RESULTS: There were 49 men and 48 women, with a mean age of 62 years. A broad range of surgeons performed UE; 36 plastic surgeons, 22 orthopedic surgeons, 17 general surgeons, 17 dermatologists, and 5 others. The mean tumor size was 4.1 cm. Local anesthesia was administered to 58 patients. Forty-five patients underwent UE without prior magnetic resonance imaging. Inappropriate transverse skin incisions were performed in 42 patients. Of the 97 patients, 82 underwent re-excision after UE. The mean time between UE and date of initial presentation at the referral hospital was 46 days. The mean interval between UE and re-excision was 96 days. Of the 82 patients, 59 underwent soft-tissue reconstruction after re-excision. CONCLUSION: A broad range of surgeons performed UE. Continuous education about STS should be considered for all surgeons. UE should be avoided because residual tumors are common, and reconstructive surgery may be necessary.2024, In vivo (Athens, Greece), 38(6) (6), 2712 - 2717, English, International magazineScientific journal
- Background and Objectives: Bone metastasis cancer boards (BMCBs) focusing on the management of bone metastases have been gathering much attention. However, the association of BMCBs with spinal surgery in patients with spinal metastases remains unclear. In this retrospective single-center observational study, we aimed to clarify the effect of a BMCB on spinal metastasis treatment. Materials and Methods: We reviewed consecutive cases of posterior decompression and/or instrumentation surgery for metastatic spinal tumors from 2008 to 2019. The BMCB involved a team of specialists in orthopedics, rehabilitation medicine, radiation oncology, radiology, palliative supportive care, oncology, and hematology. We compared demographics, eastern cooperative oncology group performance status (ECOGPS), Barthel index (BI), number of overall versus emergency surgeries, and primary tumors between patients before (2008-2012) and after (2013-2019) BMCB establishment. Results: A total of 226 patients including 33 patients before BMCB started were enrolled; lung cancer was the most common primary tumor. After BMCB establishment, the mean patient age was 5 years older (p = 0.028), the mean operating time was 34 min shorter (p = 0.025), the mean hospital stay was 34.5 days shorter (p < 0.001), and the mean BI before surgery was 12 points higher (p = 0.049) than before. Moreover, the mean number of surgeries per year increased more than fourfold to 27.6 per year (p < 0.01) and emergency surgery rates decreased from 48.5% to 29.0% (p = 0.041). Patients with an unknown primary tumor before surgery decreased from 24.2% to 9.3% (p = 0.033). Postoperative deterioration rates from 1 to 6 months after surgery of ECOGPS and BI after BMCB started were lower than before (p = 0.045 and p = 0.027, respectively). Conclusion: The BMCB decreased the emergency surgery and unknown primary tumor rate despite an increase in the overall number of spinal surgeries. The BMCB also contributed to shorter operation times, shorter hospital stays, and lower postoperative deterioration rates of ECOGPS and BI.Nov. 2023, Medicina (Kaunas, Lithuania), 59(12) (12), English, International magazineScientific journal
- (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese左第2肋骨に生じた骨軟骨腫を胸腔鏡補助下に摘出した一例
- (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese30年の経過を経てChronic expanding hematomaを合併し増大した大腿部Gossypiboma(ガーゼオーマ)の1例
- (公社)日本リハビリテーション医学会, Oct. 2023, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S355 - S355, Japanese骨転移患者に対するリハビリテーション治療効果 傾向スコアマッチングを用いた検討
- (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 318 - 318, Japanese左第2肋骨に生じた骨軟骨腫を胸腔鏡補助下に摘出した一例
- (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1892 - S1892, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索
- The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70-79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70-79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.Jul. 2023, Journal of clinical medicine, 12(14) (14), English, International magazineScientific journal
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1382 - S1382, Japanese小児中足骨発生の類上皮血管内皮腫の1例
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1435 - S1435, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1439 - S1439, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1440 - S1440, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1382 - S1382, Japanese
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1435 - S1435, Japanese骨肉腫細胞におけるSPRR1Aの機能の探索
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1439 - S1439, Japanese化学療法と炭素イオン線治療により5年生存し,歩行機能を温存しえた71歳の寛骨臼骨肉腫の1例
- (公社)日本整形外科学会, Jun. 2023, 日本整形外科学会雑誌, 97(6) (6), S1440 - S1440, Japanese本邦における骨盤発生悪性骨・軟部腫瘍に対する手術と粒子線の治療成績の比較
- PURPOSE: The aim of this systematic review was to investigate the clinical and functional knee outcomes after Verasense sensor-assisted total knee arthroplasty (VA TKA), and to compare these outcomes, where possible, with those from manually balanced total knee arthroplasty (MB TKA). METHODS: A systematic literature search following PRISMA guidelines was conducted on PubMed, Embase, Medline and Scopus from the beginning of January 2012 until the end of June 2022, to identify potentially relevant articles for this review. Selection was based on the following inclusion criteria: full text English- or German-language clinical studies, published in peer-reviewed journals, which assessed clinical and functional outcomes following VA TKA. Not original research, preprints, abstract-only papers, protocols, reviews, expert opinion papers, book chapters, surgical technique papers, and studies pertaining only to unicondylar knee arthroplasty (UKA) or patellofemoral arthroplasty (PFA) were excluded. Several scores (Knee Society Score [KSS], Oxford Knee Score [OKS], Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC], Knee injury and Osteoarthritis Outcome Score-4 subscales [KOOS4] and Physical Function-Computerised Adaptive Testing [PF-CAT]), alongside postoperative measurements of range of motion [ROM], reoperation rates and the rate of manipulation under anaesthesia [MUA]) were used to evaluate clinical and functional outcomes. The quality of included papers, except randomised control trials (RCTs), was evaluated using the Methodological Index for Non-Randomised Studies (MINORS). For the assessment of included RCTs, the Jadad Scale was used. RESULTS: The literature search identified 243 articles. After removing duplicates, 184 papers were included in the initial screening process. Fourteen of them met all the inclusion criteria following the selection process. Mean MINORS for non-comparative studies value was 11.5 (11-12), and for comparative studies 18.2 (13-21). Mean Jadad Scale score was 3.6 (2-5). Outcomes from a total number of 3633 patients were evaluated (mean age at surgery 68.5 years [32-88 years]). In terms of clinical outcomes, the overwhelming majority of studies observed an improvement after VA TKA, but no statistically significant difference in ROM and reoperation rate when compared to MB TKA. On the other hand, lower rates of MUA have been described in the VA TKA group. An increase in postoperative clinical and functional scores values, when compared to the preoperative ones, has been reported in both groups, although no statistically significant difference between them has been observed. CONCLUSION: The use of Verasense pressure sensors in TKA leads to no significant improvement in ROM, reoperation rate or functional outcomes, when compared to the standard manually balancing technique. However, lower rates of MUA have been described in the VA TKA group. These findings highlight the importance of tools being able to measure ligament stresses or joint pressure for achieving an optimally balanced knee. LEVEL OF EVIDENCE: III.May 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(5) (5), 1851 - 1858, English, International magazineScientific journal
- (公社)日本リハビリテーション医学会, May 2023, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 1 - 4, Japanese骨転移キャンサーボードが骨転移患者のQOLに及ぼす影響に関する検討
- (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S957 - S957, Japanese
- (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 305 - 305, Japanese足趾に生じた粘液型脂肪肉腫の一例
- (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S957 - S957, Japanese本邦における骨盤発生悪性骨・軟部腫瘍の臨床成績と予後因子の検討
- (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 305 - 305, Japanese足趾に生じた粘液型脂肪肉腫の一例
- Background: Symptomatic spinal metastasis (SSM) decreases the activities of daily living (ADL) and quality of life of cancer patients. However, the risk factors for SSM onset remain unclear. This prospective cohort study aimed to statistically analyze the significant risk factors. Methods: From 2016 to 2018, 210 consecutive patients with spinal metastases were prospectively registered. Patients with SSM at the first consultation and those who were unable to be followed-up owing to poor general condition were excluded. The demographic factors (age, sex, primary cancer, performance status, and ADL), clinical factors (radiation therapy, chemotherapy, molecularly targeted drugs, and bone-modifying agents (BMAs)), and Spinal Neoplastic Instability Score (SINS) were evaluated. Multivariate analysis was performed to identify the risk factors for SSM onset. Furthermore, the threshold was calculated from the receiver operating characteristic curve using the Youden index. Results: Thirty-nine patients who presented with SSM at the first consultation and 43 patients who were unable to be followed-up owing to poor general condition were excluded. Finally, 128 asymptomatic patients were included. Thirty-seven patients (28.9%) developed SSM during the follow-up period. The total SINS (OR: 1.739; 95% CI: 1.345-2.250) was identified as the most significant factor. The cut-off value of the SINS was 9.5 (sensitivity: 67.6%; specificity: 83.5%). Twenty-five (62.5%) of the forty patients with a SINS ≥ 10 developed SSM within a mean of 5.5 months (95% CI: 1.17-9.83). Furthermore, all patients with a SINS ≥ 13 developed SSM (n = 5) within a mean of 1.37 months (95% CI: 0.0-3.01). Conclusions: This study identified the significant risk factors for SSM onset and the threshold of the SINS. If long-term survival is expected, patients with a SINS ≥ 10 should be considered for intervention to prevent SSM.Feb. 2023, Cancers, 15(4) (4), English, International magazineScientific journal
- OBJECTIVES: Graves' disease (GD) has been highlighted as a possible adverse effect of the respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine. However, it is unknown if the SARS-CoV-2 vaccine disrupts thyroid autoimmunity. We aimed to present long-term follow-up of thyroid autoimmunity after the SARS-CoV-2 BNT162b2 mRNA vaccine. METHODS: Serum samples collected from seventy Japanese healthcare workers at baseline, 32 weeks after the second dose (pre-third dose), and 4 weeks after the third dose of the vaccine were analyzed. The time courses of anti-SARS-CoV-2 spike immunoglobulin G (IgG) antibody, thyroid-stimulating hormone receptor antibody (TRAb), and thyroid function were evaluated. Anti-thyroglobulin antibodies (TgAb) and anti-thyroid peroxidase antibodies (TPOAb) were additionally evaluated in thirty-three participants. RESULTS: The median age was 50 (IQR, 38-54) years and 69% were female. The median anti-spike IgG antibody titer was 17627 (IQR, 10898-24175) U/mL 4 weeks after the third dose. The mean TRAb was significantly increased from 0.81 (SD, 0.05) IU/L at baseline to 0.97 (SD, 0.30) IU/L 4 weeks after the third dose without functional changes. An increase in TRAb was positively associated with female sex (β = 0.32, P = 0.008) and low basal FT4 (β = -0.29, P = 0.02) and FT3 (β = -0.33, P = 0.004). TgAb was increased by the third dose. Increase in TgAb was associated with history of the thyroid diseases (β = 0.55, P <0.001). CONCLUSIONS: SARS-CoV-2 BNT162b2 mRNA vaccine can disrupt thyroid autoimmunity. Clinicians should consider the possibility that the SARS-CoV-2 vaccine may disrupt thyroid autoimmunity.2023, Frontiers in endocrinology, 14, 1058007 - 1058007, English, International magazineScientific journal
- INTRODUCTION: The introduction of tyrosine kinase inhibitors has revolutionized treatment strategies for metastatic renal cell carcinoma (RCC) and has improved survival rates. The number of patients with bone metastases from RCC requiring surgery will increase as survival rates improve. However, there is insufficient evidence to standardize the treatment of bone metastases after the introduction of targeted therapy for metastatic RCC. We aimed to determine the outcomes of palliative surgical treatment of bone metastases in the extremities of patients with metastatic RCC. MATERIALS AND METHODS: We retrospectively reviewed 26 lesions from 17 patients who underwent surgery for extremity and acetabular bone metastases and were treated with targeted therapies for advanced RCC between 2008 and 2020. The median follow-up duration was 19 months (range, 4-76). We assessed the patients' activities of daily living, quality of life, and pain and analyzed their postoperative values relative to preoperative values. Postoperative overall survival (OS), local progression-free survival (LPFS), and the factors affecting them were evaluated using the Kaplan-Meier method and log-rank test. RESULTS: The 5-year OS and LPFS rates were 39.5% and 65.6%, respectively. The factors affecting OS were sex, Katagiri score, visceral metastases, and preoperative targeted therapy, while the factors affecting LPFS were pathologic fractures and surgical technique. CONCLUSION: In this study, the postoperative outcomes of palliative surgery for bone metastases from metastatic RCC were good. We suggest that systemic treatment should be prioritized over local control for advanced bone metastasis in RCC and surgery before pathological fracture should be performed for local control.Nov. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 49(5) (5), 928 - 933, English, International magazineScientific journal
- Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.Nov. 2022, International journal of oncology, 61(5) (5), English, International magazineScientific journal
- The effect of spine surgery for symptomatic spinal metastases (SSM) on patient prognosis remains unclear. This study aimed to reveal the prognosis of patients with SSM after spine surgery. One hundred twenty-two patients with SSM were enrolled in this prospective cohort study. The patients who received chemotherapy after enrollment were excluded. The decision of surgery depended on patient's willingness; the final cohort comprised 31 and 24 patients in the surgery and non-surgery groups, respectively. The patients were evaluated by their performance status (PS), activities of daily living (ADL) and ambulatory status. Survival was evaluated by the Kaplan-Meier method. The PS, ADL and ambulation were significantly improved in the surgery group compared to non-surgery group. The median survival was significantly longer in the surgery group (5.17 months, 95% confidence interval (CI) 3.27 to 7.07) than in the non-surgery group (2.23 months, 95% CI 2.03 to 2.43; p = 0.003). Furthermore, the patients with a better PS, ADL and ambulatory status had a significantly longer survival. Surgery improved the PS, ADL, ambulation and survival of patients with SSM. In the management of SSM, spine surgery is not only palliative but may also prolong survival.Oct. 2022, Journal of clinical medicine, 11(21) (21), English, International magazineScientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2022, 中部日本整形外科災害外科学会雑誌, 65(5) (5), 746 - 746, Japanese内軟骨腫との鑑別を要した小児中足骨発生の類上皮血管内皮腫の1例
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, JapaneseEwing肉腫におけるslow-cycling cellsの同定
- (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1761 - S1761, Japanese
- This study aimed to retrospectively analyze the clinical outcomes of patients with pelvic and retroperitoneal bone and soft tissue sarcoma (BSTS). Overall, 187 patients with BSTS in the pelvis and retroperitoneal region treated at 19 specialized sarcoma centers in Japan were included. The prognostic factors related to overall survival (OS), local control (LC), and progression-free survival (PFS) were evaluated. The 3-year OS and LC rates in the 187 patients were 71.7% and 79.1%, respectively. The 3-year PFS in 166 patients without any distant metastases at the time of primary tumor diagnosis was 48.6%. Osteosarcoma showed significantly worse OS and PFS than other sarcomas of the pelvis and retroperitoneum. In the univariate analyses, larger primary tumor size, soft tissue tumor, distant metastasis at the time of primary tumor diagnosis, P2 location, chemotherapy, and osteosarcoma were poor prognostic factors correlated with OS. Larger primary tumor size, higher age, soft tissue tumor, chemotherapy, and osteosarcoma were poor prognostic factors correlated with PFS in patients without any metastasis at the initial presentation. Larger primary tumor size was the only poor prognostic factor correlation with LC. This study has clarified the epidemiology and prognosis of patients with pelvic and retroperitoneal BSTS in Japan.MDPI AG, Jun. 2022, Cancers, 14(12) (12), 3023 - 3023, English, International magazineScientific journal
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1346 - S1346, Japanese骨肉腫肺転移症例の検討
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1348 - S1348, Japanese骨盤発生悪性骨・軟部腫瘍の治療成績と予後因子の検討
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1352 - S1352, Japanese手足に生じた軟部肉腫の治療成績と予後因子に関する検討
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1356 - S1356, Japanese悪性末梢神経鞘腫瘍の治療成績
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1371 - S1371, Japanese腹腔外デスモイド型線維腫症に対するWait & Seeの治療成績
- (公社)日本整形外科学会, Jun. 2022, 日本整形外科学会雑誌, 96(6) (6), S1428 - S1428, JapaneseEwing肉腫におけるslow-cycling cellの同定
- 症例は11歳女児で、学校体育中に右膝痛が出現し、受診時には右膝近位部内側に軽度腫脹と圧痛がみられ、血液検査では炎症反応の軽度上昇を呈した。単純X線像、CT像では右脛骨近位部内側に溶骨性病変が描出され、MRIでは同部位にT1強調像で等信号、STIR像で高信号の異常信号域を認めたため、骨腫瘍、炎症性疾患の疑いで切開生検術を行った。病理組織学的検査では多数の炎症性細胞を認めたが、組織培養検査は陰性であり、骨シンチグラフィーとPET-CT検査で右脛骨近位部や右坐骨に集積を認めたため、慢性再発性多発性骨髄炎(CRMO)と診断した。非ステロイド性抗炎症薬(NSAIDs)内服のみで経過を観察し、術後1年2ヵ月時に左手関節にCRMO再発を認めたものの、初発・再発時ともNSAIDsにて症状は改善した。(一社)中部日本整形外科災害外科学会, May 2022, 中部日本整形外科災害外科学会雑誌, 65(3) (3), 403 - 404, Japanese
- (公社)日本リハビリテーション医学会, May 2022, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S274 - S274, Japaneseキャンサーボードを用いた骨転移患者診療の経時的変化
- (公社)日本リハビリテーション医学会, May 2022, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S642 - S642, Japanese両大腿骨切迫骨折に対し、両側髄内定固定術を施行された一症例
- 金原出版(株), Apr. 2022, 臨床放射線, 67(4) (4), 365 - 371, JapaneseKobe University bone metastasis board and community cooperation for bone metastasis care
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, Japanese
- (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S113 - S113, JapaneseEwing肉腫におけるslow-cycling cellの同定
- Purpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE. Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE. Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥61 years) and a larger primary tumor (≥2.9 cm). Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.2022, Cancer management and research, 14, 1815 - 1824, English, International magazineScientific journal
- Proximal-type epithelioid sarcoma is an aggressive malignant soft-tissue neoplasm, a "proximal" variant of epithelioid sarcoma, resistant to multimodal therapy and involved in early tumor-related death. Pertinent treatments are, therefore, continually being explored. A 24-year-old woman with nonmetastatic proximal-type epithelioid sarcoma, originating subcutaneously on the right side of the vulva, underwent surgical resection; the lesion recurred, however, leading to death 3 months after the second surgery. Here described is a case of proximal-type epithelioid sarcoma expressing L-type amino acid transporter 1 (LAT1) that transports essential amino acids and p-borono-L-phenylalanine (BPA)-the chemical compound used in boron neutron capture therapy (BNCT)-and is highly expressed in many malignant tumors. Recently, LAT1 has drawn attention, and relevant treatments have been studied-LAT1 inhibitor and BNCT. LAT1 expression in proximal-type epithelioid sarcoma may lead to cogent treatments for the disease.2022, SAGE open medical case reports, 10, 2050313X211067917, English, International magazineScientific journal
- Osteolytic bone metastasis leads to skeletal‑related events, resulting in a decline in the patient activities and survival; therefore, it is important to understand the mechanism underlying bone metastasis. Recent studies have suggested that microRNAs (miRNAs or miRs) are involved in osteoclast differentiation and/or osteolytic bone metastasis; however, the roles of miRNAs have not been elucidated. In the present study, the roles of miRNAs in bone destruction caused by breast cancer metastasis were investigated in vitro and in vivo. miR‑16, miR‑133a and miR‑223 were transfected into a human breast cancer cell line, MDA‑MB‑231. The expression of osteolytic factors in conditioned medium (miR‑CM) collected from the culture of transfected cells was assessed. To evaluate the effects of miRNAs on osteoclast differentiation and activities, tartrate‑resistant acid phosphatase (TRAP) staining and bone resorptive assays were performed in osteoclasts following miR‑CM treatment. To create in vivo bone metastasis models for histological and morphometric evaluation, miRNA‑transfected MDA‑MB‑231 cells were transplanted into the proximal tibia of nude mice. Expression of osteolytic factors, including receptor activator for nuclear factor‑κB ligand (RANKL), interleukin (IL)‑1β, IL‑6, parathyroid hormone‑related protein (PTHrP), and tumor necrosis factor (TNF), was increased in miR‑16‑CM, whereas it was decreased in both miR‑133a‑CM and miR‑223‑CM. TRAP staining and bone resorptive assays revealed that osteoclast function and activities were promoted by miR‑16‑CM treatment, whereas they were suppressed by miR‑133a‑CM and miR‑223‑CM. Consistent with in vitro findings, in vivo experiments revealed that the overexpression of miR‑16 increased osteoclast activities and bone destruction in MDA‑MB‑231 cells, whereas the opposite results were observed in both miR‑133a‑ and miR‑223‑transfected MDA‑MB‑231 cells. Our results indicated that miR‑16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR‑133a and miR‑223 suppressed them. These miRNAs could be potential biomarkers and therapeutic targets for breast cancer bone metastasis.Nov. 2021, International journal of oncology, 59(5) (5), English, International magazineScientific journal
- 悪性軟部腫瘍の肺転移113例を対象に、原発診断時年齢、性別、原発病変の発生部位および深達、原発病変のサイズ、組織型、原発病変に対する治療法、局所再発の有無、原発診断時肺転移の有無、肺転移の側性および肺転移結節数、原発診断後転移出現までの期間、肺転移病変に対する治療法、肺外転移の有無を調査した。肺転移後の生存期間と生存率を肺転移診断時を起点としてKaplan-Meier法を用いて算出し、各因子が与える影響についてlog-rank検定による単変量解析を行った。更に単変量解析で検出された因子についてCox比例ハザードモデルを用いた多変量解析を行った。その結果、肺転移後の生存に有意な影響を与える因子は肺転移巣の有無であり、肺転移巣切除が悪性軟部腫瘍の患者の生存期間を延長させることが判明した。肺転移巣切除が困難な症例では化学療法により良好な予後が得られると考えられた。(株)南江堂, Oct. 2021, 別冊整形外科, (80) (80), 21 - 26, Japanese
- (株)南江堂, Oct. 2021, 別冊整形外科, (80) (80), 21 - 26, JapaneseTreatment approach for pulmonary metastasis in patients with soft tissue sarcoma
- (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 235 - 235, Japanese慢性再発性多発性骨髄炎の一例
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1551 - S1551, JapaneseEwing肉腫におけるslow-cycling cellsの同定
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1621 - S1621, Japanese
- (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1551 - S1551, JapaneseEwing肉腫におけるslow-cycling cellsの同定
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1273 - S1273, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1295 - S1295, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1319 - S1319, JapaneseEwing肉腫におけるslow-cycling cellsの同定
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1343 - S1343, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1352 - S1352, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1364 - S1364, Japanese乳癌骨転移における骨破壊に寄与するmiRNAの探索
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1396 - S1396, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1273 - S1273, Japanese骨盤悪性骨腫瘍に対する粒子線治療の長期成績
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1295 - S1295, Japanese滑膜肉腫に対するL型アミノ酸トランスポータ1(LAT1)の発現およびホウ素中性子捕捉療法(BNCT)適応の検討
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1319 - S1319, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1343 - S1343, Japanese高齢者に発症した骨巨細胞腫についての調査結果
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1352 - S1352, Japanese軟部肉腫における無計画切除例の治療成績と予後因子の検討
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1364 - S1364, Japanese
- (公社)日本整形外科学会, Jun. 2021, 日本整形外科学会雑誌, 95(6) (6), S1396 - S1396, Japanese未分化多形肉腫の治療成績
- Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazineScientific journal
- Capicua transcriptional repressor (CIC)-rearranged sarcoma is an Ewing-like sarcoma with an aggressive clinical course and poor prognosis. No standard treatment has been established. The present study describes a case of CIC-rearranged sarcoma with lung metastases developing in a 24-year-old woman as a therapy-associated malignancy following chemotherapy for anaplastic large cell lymphoma at nine years old. This was treated with palliative regimens used for Ewing sarcoma. The patient achieved disease control for one year. Of note, ifosfamide and etoposide (IE), which were used as a second line treatment lead to a partial response. The case described in the present study indicated that treatment with Ewing regimens is a reasonable option for patients with metastatic CIC-rearranged sarcoma, including those with a second malignant case.Apr. 2021, Molecular and clinical oncology, 14(4) (4), 68 - 68, English, International magazineScientific journal
- (一社)中部日本整形外科災害外科学会, Mar. 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 168 - 168, JapaneseDouble LCP platingによる手関節固定術の治療経験
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S897 - S897, Japanese軟部肉腫肺転移患者における肺転移の治療アプローチの予後への影響
- (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S897 - S897, Japanese
- Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.Mar. 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407 - 109407, English, International magazineScientific journal
- BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM). PATIENTS AND METHODS: Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival. RESULTS: Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01). CONCLUSION: Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.Feb. 2021, Anticancer research, 41(2) (2), 1027 - 1034, English, International magazineScientific journal
- Chondrolipoma is, based on the limited case reports available, an extremely rare histological variant of lipoma with the proliferation of mature adipocytes containing an area of true hyaline cartilage. Chondrolipoma is characterized by adult onset and is often identified in the breast, pharynx and tongue. The current study presents a case of chondrolipoma of the finger in an 11 year-old girl. Physical examination indicated a well-defined elastic soft mass, measuring 2.5x2 cm, on the dorsal aspect of the proximal phalanx of the left middle finger. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion with heterogeneous signal intensity. On T1- and T2-weighted images, the lesion indicated a predominantly marked hyperintense signal containing linear hypointense regions, and on fat-suppressed short-tau inversion recovery sequences, the lesion indicated a predominant hypointensity, with linear regions displaying hyperintensity. Marginal excision of the tumor was performed. Histologically, the major component of the tumor was mature adipose tissue containing a limited area of mature hyaline cartilage matrix, without lipoblasts or malignancy. The postoperative course of the patient was excellent, with no local recurrence three years after surgery. To the best of our knowledge, the current study outlines the first pediatric case of chondrolipoma arising in the finger.Jan. 2021, Molecular and clinical oncology, 14(1) (1), 2 - 2, English, International magazineScientific journal
- Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare, malignant tumor arising in lower extremities with no effective treatment other than wide surgical resection. Here described is a case of primary CCS in the peroneal tendon of the right foot of a 54-year-old woman enrolled to undergo BNCT. The tumor mass post-BNCT disappeared totally without damage to other normal tissue, demonstrating, for the first time, the potential efficacy of BNCT in complete local control of CCS.Dec. 2020, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 166, 109324 - 109324, English, International magazineScientific journal
- We herein describe soft tissue tumor arising in the lower extremity of a pediatric patient. The tumor displayed a unique and wide range of histological features, sheet-like and cohesive growth pattern consisting of enlarged round to epithelioid atypical cells with a large alveolar and pseudopapillary histological architecture, focally mimicking alveolar soft part sarcoma and MiT family translocation renal cell carcinoma. Tumor cells were focally immunoreactive for cytokeratin, S-100, and EMA. RNA sequencing identified a novel in-frame NR1D1 (exon 5)-MAML1 (exon 2) gene rearrangement resulting in the formation of a putative chimeric protein containing the N-terminal C4-type zing finger domains of NR1D1 and the C-terminal MAML1 protein, which was confirmed by subsequent RT-PCR, Sanger sequencing, and FISH assay. To the best of our knowledge, NR1D1-MAML1 fusion has not yet been described in any neoplasms, suggesting the emergence of a novel tumor entity.Dec. 2020, Virchows Archiv : an international journal of pathology, 477(6) (6), 891 - 895, English, International magazine[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S195 - S195, Japaneseがんロコモとリハビリテーション医学・医療 がんロコモと骨転移
- (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S307 - S307, Japanese骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討
- BACKGROUND: Cancer stem cells (CSCs) are considered to be responsible for tumor initiation, formation, and poor prognosis of cancer patients. However, the rarity of CSCs in clinical samples makes it difficult to elucidate characteristics of CSCs, especially in osteosarcoma (OS). The aim of this study is to verify whether it is possible to generate CSC-like cells by transducing defined factors into an OS cell line. METHODS: We retrovirally transduced the Octamer-binding transcription factor 3/4 (OCT3/4), Kruppel-like factor 4 (KLF4), and SRY-box transcription factor 2 (SOX2) genes into the MG-63 human OS cell line (MG-OKS). Parental and GFP-transduced MG-63 cells were used as negative control. We assessed the properties of the generated cells in vitro and in vivo. Multiple comparisons among groups were made using a one-way analysis of variance (ANOVA) followed by post hoc testing with Tukey's procedure. RESULTS: MG-OKS cells in vitro exhibited the significantly increased mRNA expression levels of CSC markers (CD24, CD26, and CD133), decreased cell growth, increased chemoresistance and cell migration, and enhanced sphere formation. Notably, MG-OKS cells cultured under osteogenic differentiation conditions showed strongly positive staining for both Alizarin Red S and alkaline phosphatase, indicating osteogenesis of the cells. Gene ontology analysis of microarray data revealed significant upregulation of epidermal-related genes. Tumors derived from MG-OKS cells in vivo were significantly larger than those from other cells in μCT analysis, and immunohistochemical staining showed that Ki-67, osteocalcin, and HIF-1α-positive cells were more frequently detected in the MG-OKS-derived tumors. CONCLUSIONS: In this study, we successfully generated OS CSC-like cells with significantly enhanced CSC properties following transduction of defined factors.Oct. 2020, Stem cell research & therapy, 11(1) (1), 429 - 429, English, International magazineScientific journal
- Soft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin. Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, being the major cause of mortality in patients with metastatic STS. Pulmonary metastasectomy has been reported to contribute to long-term survival; however, an appropriate treatment has not been established. We aimed to identify factors associated with post-metastasis survival in STS patients with pulmonary metastasis and determine the appropriate treatment for each patient. We retrospectively reviewed the records of metastatic STS patients treated between 2000 and 2017 and analyzed the clinico-pathologic variables to identify factors associated with the survival. The median survival after pulmonary metastasis was 20.6 months, and the 1-, 3-, and 5-year survival rates were 68.6%, 36.0%, and 25.1%, respectively. The survival was significantly greater in patients who underwent pulmonary metastasectomy than in those without surgery (38.9 months vs. 10.5 months; p < 0.0001). Among those who did not undergo surgery, the survival was significantly greater in patients who received chemotherapy than in those without chemotherapy (19.1 months vs. 6.3 months, p = 0.037). Multivariate analysis identified pulmonary metastasectomy as the most important prognostic factor for post-metastasis survival (Hazard ratio 5.623; 95% Confidence Interval 2.733-11.572; p < 0.0001). In conclusion, pulmonary metastasectomy was the most important prognostic factor for post-metastasis survival in patients with metastatic STS. In addition, chemotherapy could prolong survival in patients who were not eligible for pulmonary resection. Although we should carefully weigh the risks and benefits, appropriate treatment for pulmonary metastases could contribute to long-time survival.Aug. 2020, Clinical & experimental metastasis, 37(4) (4), 509 - 517, English, International magazine[Refereed]Scientific journal
- Jul. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 724 - 728, English, Domestic magazine[Refereed]Scientific journal
- May 2020, Pediatric hematology and oncology, 37(4) (4), 337 - 343, English, International magazine[Refereed]Scientific journal
- Apr. 2020, JBJS case connector, 10(2) (2), e0274Scientific journal
- Apr. 2020, Genes, chromosomes & cancer, 59(4) (4), 249 - 254, English, International magazine[Refereed]Scientific journal
- Jul. 2019, BMC cancer, 19(1) (1), 725 - 725, English, International magazine[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, Japaneseがんの骨転移症例に対するリハビリテーション医療の現状と症例検討[Refereed]
- 日本脊椎脊髄病学会, May 2019, Journal of spine research : official journal of the Japanese Society for Spine Surgery and Related Research, 10(5) (5), 898 - 904, JapaneseThe Effectiveness and Limitation of Spine Surgery for Spinal Metastasis
- (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S806 - S806, Japanese四肢の腎癌骨転移に対して手術を施行した症例の検討[Refereed]
- An infant boy underwent hip disarticulation for infantile fibrosarcoma immediately after birth. His rehabilitation began when he was 4 mos old and involved training with his left (residual) leg. He could stand with support at 12 mos. His initial prosthesis fitting was performed at the age of 13 mos. He could stand and walk with support at 15 mos of age and could walk with no additional support and go up and down stairs at 2 yrs. A single-axis prosthetic knee joint was introduced at the age of 2 yrs 3 mos. His first gait using a hip prosthesis was successful, and his prosthesis was replaced at appropriate intervals with no major problems. The authors believe that the key to achieving a successful prosthetic gait in children is good communication among the medical team, which should comprise an orthopedic doctor, rehabilitation doctor, nurse, physical therapist, prosthetist/orthotist, and the patient's parents.Oct. 2018, American journal of physical medicine & rehabilitation, 97(10) (10), e90-e92 - e92, English, International magazine[Refereed]Scientific journal
- 日本内分泌外科学会・日本甲状腺外科学会, Oct. 2018, 日本内分泌・甲状腺外科学会雑誌, 35(Suppl.2) (Suppl.2), S319 - S319, Japanese甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討[Refereed]
- Hypoxia plays a significant role in cancer progression, including metastatic bone tumors. We previously reported that transcutaneous carbon dioxide (CO2) application could decrease tumor progression through the improvement of intratumor hypoxia. Therefore, we hypothesized that decreased hypoxia using transcutaneous CO2 could suppress progressive bone destruction in cancer metastasis. In the present study, we examined the effects of transcutaneous CO2 application on metastatic bone destruction using an animal model. The human breast cancer cell line MDA-MB-231 was cultured in vitro under three different oxygen conditions, and the effect of altered oxygen conditions on the expression of osteoclast-differentiation and osteolytic factors was assessed. An in vivo bone metastatic model of human breast cancer was created by intramedullary implantation of MDA-MB-231 cells into the tibia of nude mice, and treatment with 100% CO2 or a control was performed twice weekly for two weeks. Bone volume of the treated tibia was evaluated by micro-computed tomography (µCT), and following treatment, histological evaluation was performed by hematoxylin and eosin staining and immunohistochemical staining for hypoxia-inducible factor (HIF)-1α, osteoclast-differentiation and osteolytic factors, and tartrate-resistant acid phosphatase (TRAP) staining for osteoclast activity. In vitro experiments revealed that the mRNA expression of RANKL, PTHrP and IL-8 was significantly increased under hypoxic conditions and was subsequently reduced by reoxygenation. In vivo results by µCT revealed that bone destruction was suppressed by transcutaneous CO2, and that the expression of osteoclast-differentiation and osteolytic factors, as well as HIF-1α, was decreased in CO2-treated tumor tissues. In addition, multinucleated TRAP-positive osteoclasts were significantly decreased in CO2-treated tumor tissues. Hypoxic conditions promoted bone destruction in breast cancer metastasis, and reversal of hypoxia by transcutaneous CO2 application significantly inhibited metastatic bone destruction along with decreased osteoclast activity. The findings in this study strongly indicated that transcutaneous CO2 application could be a novel therapeutic strategy for treating metastatic bone destruction.Oct. 2018, Oncology reports, 40(4) (4), 2079 - 2087, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Chronic expanding hematoma is a rare entity resulting from trauma or surgery. This condition usually occurs in soft tissue, such as the trunk or extremities, while chronic expanding hematoma arising from bone has not been reported previously. We describe an unusual case of a huge intraosseous chronic expanding hematoma arising from the ilium, which had grown over a 40-year period following hip surgeries. CASE PRESENTATION: A 57-year-old Japanese woman presented with a 1.5-year history of right hip pain. She had a history of bilateral developmental dysplasia of the hip and had undergone bilateral arthroplasties in childhood. A physical examination revealed a large, firm, immobile mass at her right ilium. Based on radiographic findings, a type of slow-growing bone tumor was suspected, and an incisional biopsy was performed. A histopathologic examination revealed large amounts of old clotted blood within the lesion, and the capsule of the lesion was composed of dense, fibrous, connective tissue. There was no evidence of neoplasia, and chronic expanding hematoma was suspected. The lesion was resistant to conservative treatment, and so we performed an internal hemipelvectomy (including the capsule of the mass) and a reconstruction by hip transposition 2.5 years after the incisional biopsy. There was no recurrence of chronic expanding hematoma at the most recent follow-up of 1 year and 8 months postoperatively. CONCLUSIONS: A chronic expanding hematoma is characterized by its persistence and increasing size more than 1 month after the trauma or surgical event suspected of causing hemorrhage. To the best of our knowledge, this is the first report of chronic expanding hematoma arising from bone. We performed internal hemipelvectomy and hip transposition, and there has so far been no recurrence. This disease may be considered a differential diagnosis for bone tumor when the patient has a history of surgery or trauma, regardless of how many years have passed since the index event.Sep. 2018, Journal of medical case reports, 12(1) (1), 265 - 265, English, International magazine[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1999 - S1999, Japanese新規低接着性scaffold collagen(LASCol)はラット骨欠損モデルにおいて骨癒合を促進する[Refereed]
- (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1812 - S1812, JapaneseiPS作製技術を用いた人工骨肉腫幹細胞株の樹立[Refereed]
- (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S40 - S40, Japanese大腿骨近位部病的骨折の治療戦略 大腿骨近位部病的骨折 人工関節の適応と限界[Invited]
- (株)医学書院, Jul. 2018, 臨床整形外科, 53(7) (7), 643 - 648, Japanese全身画像検索が診断に有用であった慢性再発性多発性骨髄炎の2例[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1512 - S1512, Japanese不安定性を有する転移性脊椎腫瘍に対する治療 脊椎転移に対する手術療法の効果[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1478 - S1478, Japanese粘液線維肉腫の治療成績[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1412 - S1412, Japanese四肢の腎癌骨転移に対して手術を施行した症例の検討[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1421 - S1421, Japanese経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制する[Refereed]
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1385 - S1385, Japanese[Refereed]Research society
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 2, Japanese当院における骨転移リハビリテーションの現状と症例の検討[Refereed]
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 6, Japanese新規低接着性コラーゲン(LASCol)はラット大腿骨骨欠損モデルにおいて骨癒合を促進する[Refereed]
- (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 5, Japanese経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制できる[Refereed]
- (一社)日本脊椎脊髄病学会, Mar. 2018, Journal of Spine Research, 9(3) (3), 429 - 429, Japanese脊椎転移に対する集学的治療は予後を延長させる[Refereed]
- (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S1248 - S1248, Japanese悪性軟部腫瘍肺転移症例における予後因子[Refereed]
- (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S912 - S912, JapaneseLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFUS break-apart FISHの有用性[Refereed]
- Nov. 2017, PEDIATRIC BLOOD & CANCER, 64, S60 - S60, EnglishClinical Characteristics and Outcome of Pediatric Osteosarcoma: A Single-center Experience[Refereed]
- Nov. 2017, Anticancer research, 37(11) (11), 6097 - 6106, English, International magazine[Refereed]Scientific journal
- STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known. MATERIALS AND METHODS: Seventy patients with spinal metastasis were enrolled in this study. Forty-six patients desired and underwent spine surgery ("surgery" group) and 24 patients did not desire surgery ("nonsurgery" group). Both groups received optimal treatments, including radiation, chemotherapy, and palliative care services. Evaluation was performed at 1, 3, and 6 months after study enrollment using the Eastern Cooperative Oncology Group PS, the Barthel index (BI) for ADL, and Frankel classification for neurological status. RESULTS: There was no significant difference in baseline PS, the BI, or Frankel classification between the groups. The surgery group showed significant improvement in PS, maintaining grade 2 or less throughout the duration of the study, as well as in ADL, exceeding 70 points of the BI, compared with the nonsurgery group (P<0.05). Significantly improved neurological condition was also observed in the surgery group over the following 6 months. More than 95% of patients who underwent surgery improved their PS, the BI, and neurological status. Furthermore, >80% of these patients maintained improvement in PS, the BI, and neurological status for at least 6 months. In contrast, PS, the BI, and neurological status of patients in the "nonsurgery" group deteriorated throughout the study period. CONCLUSIONS: Spine surgery improves PS, ADL, and neurological status in patients with spinal metastasis for a minimum 6 months. This indicates that these patients can acquire an independent daily life.Oct. 2017, Clinical spine surgery, 30(8) (8), E1026-E1032, English, International magazine[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, Sep. 2017, The Japanese Journal of Rehabilitation Medicine, 54(秋季特別号) (秋季特別号), S273 - S273, Japanese当院における骨転移リハビリテーションの現状とリハ介入因子の検討[Refereed]
- (公社)日本義肢装具士協会, Jun. 2017, POアカデミージャーナル, 25(Suppl.) (Suppl.), 150 - 151, Japanese小児用股義足製作の一症例(第二報)
- Jun. 2017, International orthopaedics, 41(6) (6), 1265 - 1271, English, International magazine[Refereed]Scientific journal
- Jun. 2017, Oncology reports, 37(6) (6), 3688 - 3694, English, International magazine[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, May 2017, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 3 - 7, Japanese骨盤骨腫瘍に対して腫瘍切除後にHip transposition法を施行した2例
- (一社)日本脊椎脊髄病学会, Feb. 2017, Journal of Spine Research, 8(2) (2), 139 - 146, Japanese脊椎転移に対する集学的治療の予後改善効果[Refereed]
- Jan. 2017, International journal of oncology, 50(1) (1), 23 - 30, English, International magazine[Refereed]Scientific journal
- 在胎36週に出生した一卵性双生児の第2子で、出生直後より右下腿に鶏卵大の腫瘤が認められ、日齢12に血管腫の疑いで小児科へ入院となった。入院後、形成外科にて切開生検術を施行され、病理検査にて悪性軟部腫瘍を指摘されたため、日齢17に整形外科へ紹介となった。受診時、右下腿の腫瘤は手拳大までに増大し、MRIでは腫瘤は内部不均一な異常信号域を認めた。血液検査で高Ca血症の増悪を認めたため、日齢18に右股関節離断術が施行された。病理組織検査および遺伝子検査の結果、乳児型線維肉腫の診断が確定した。以後、第1子の立位開始、患児のつかまり立ち開始の時期を目安として、生後13ヵ月で股義足を導入し、生後24ヵ月には独歩を獲得した。生後26ヵ月よりは膝継手も導入し、生後34ヵ月でジャンプや患側を軸にボールをける動作が可能で、腫瘍の再発や転移も認められていない。(一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(5) (5), 917 - 918, Japanese[Refereed]Scientific journal
- Jul. 2016, JOURNAL OF FOOT & ANKLE SURGERY, 55(4) (4), 838 - 841, English[Refereed]Scientific journal
- (公社)日本リハビリテーション医学会, Jun. 2016, The Japanese Journal of Rehabilitation Medicine, 53(JARM2016) (JARM2016), I206 - I206, Japanese脊椎転移に対する手術加療の費用対効用
- (一社)日本脊椎脊髄病学会, Jan. 2016, Journal of Spine Research, 7(1) (1), 25 - 30, Japanese70歳以上脊椎転移に対する手術成績[Refereed]
- (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(5) (5), 1076 - 1077, Japanese初発転移が膵であった腓骨原発骨肉腫の1例
- Sep. 2015, International journal of oncology, 47(3) (3), 891 - 9, English, International magazine[Refereed]Scientific journal
- Sep. 2015, INTERNATIONAL JOURNAL OF ONCOLOGY, 47(3) (3), 891 - 899, English[Refereed]Scientific journal
- 9歳男児。幼少期より左足関節内側に腫瘤があり、7歳頃より同部位に疼痛を認め次第に増悪した。単純X線およびCTでは距骨内側に骨化を伴う異常陰影を認め、距骨側には圧迫による陥没変形を認めた。滑膜性骨軟骨腫症や骨外性軟骨腫、Trevor病などを疑い、全身麻酔下に腫瘍切除術を施行した。病理組織学的には腫瘍の中心部に骨組織を認め、周辺では硝子軟骨組織を認め、一部に腫瘍周囲滑膜との連続性を認めた。なお、既存骨との連続性は認めなかった。術直後より疼痛は消失し、足関節の可動域も改善した。術後7ヵ月の時点で腫瘍の再発は認めていない。(一社)中部日本整形外科災害外科学会, Jul. 2015, 中部日本整形外科災害外科学会雑誌, 58(4) (4), 717 - 718, Japanese
- 症例は生後18日男児(一卵性双生児の第2子)で、出生直後より右下腿に鶏卵大の腫瘤を認め、腫瘤は増大傾向にあり、切開生検にて悪性軟部腫瘤が疑われたため、当科紹介入院となった。入院後、腫瘍の増大が急速であり、腫瘍産生性と考えられる高Ca血症の増悪を認めたため、日齢18に右股関節離断術を施行した。病理組織学的所見および遺伝子検査でETV6-NTRK3キメラ遺伝子を認めたことから、乳児型線維肉腫と確定診断した。術後、血中Ca値は正常化し、経過良好で日齢43に退院となった。1年4ヵ月経過した現在、局所再発や転移は認めない。(一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(2) (2), 275 - 276, Japanese
- (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 144 - 144, Japanese緊急的に股関節離断術を施行した乳児型線維肉腫の一例[Refereed]
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1682 - S1682, Japanese炭酸ガス経皮投与による低酸素環境の改善は悪性線維性組織球腫のiPS関連遺伝子の発現を低下させる[Refereed]
- Aug. 2014, INTERNATIONAL JOURNAL OF ONCOLOGY, 45(2) (2), 732 - 738, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1683 - S1683, JapaneseSurvivin抑制薬"YM155"はMFH細胞において腫瘍増殖を抑制する
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1552 - S1552, JapaneseMRI造影剤投与後の骨中ガドリニウム濃度について
- (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1685 - S1685, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果[Refereed]
- (公社)日本整形外科学会, Jun. 2014, 日本整形外科学会雑誌, 88(6) (6), S1276 - S1276, Japanese新生児の下肢に発症した乳児線維肉腫の1例
- (公社)日本整形外科学会, Jun. 2014, 日本整形外科学会雑誌, 88(6) (6), S1127 - S1127, JapaneseSurvivin抑制薬YM155はヒトMFH細胞の腫瘍増殖能を抑制する
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S257, Japanese当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組み
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S259, Japanese転移性脊椎腫瘍に対する手術成績 手術、非手術例の全身状態、日常生活動作に関する前向き研究
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S356, Japanese著明な骨融解像を伴う骨盤骨転移患者に発症から緩和期までリハビリテーション介入を行った1例
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S261, Japanese炭酸ガス経皮投与は骨軟部肉腫においてiPS関連遺伝子の発現を低下させる
- May 2014, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S491, Japanese大腿切断5年後に発症した断端神経腫の1例
- Mar. 2014, Journal of Spine Research, 5(3号) (3号), 487, Japanese転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究
- Mar. 2014, 日本整形外科学会雑誌, 88(3号) (3号), S930, Japanese転移性脊椎腫瘍への最新の知見 転移性脊椎腫瘍に対する手術成績 手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S643 - S643, Japanese炭酸ガス経皮投与は乳癌骨転移による骨破壊を抑制する
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S371 - S371, Japanese炭酸ガス経皮投与は骨・軟部肉腫におけるiPS関連遺伝子の発現を低下させる
- (一社)中部日本整形外科災害外科学会, Mar. 2014, 中部日本整形外科災害外科学会雑誌, 57(春季学会) (春季学会), 127 - 127, Japanese炭酸ガスと放射線併用療法による骨軟部肉腫に対する新しい治療法戦略の確立
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S365 - S365, Japanese骨・軟部腫瘍 希少疾患に光明をもたらす夢の実現へ 悪性骨・軟部腫瘍に対する炭酸ガス経皮投与療法
- Mar. 2014, Journal of Spine Research, 5(3号) (3号), 570, Japanese高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究
- Jan. 2014, SCIENTIFIC REPORTS, 4, English[Refereed]Scientific journal
- Jan. 2014, SCIENTIFIC REPORTS, 4, English[Refereed]Scientific journal
- (NPO)日本小児血液・がん学会・(NPO)日本小児がん看護学会・(公財)がんの子供を守る会, Nov. 2013, 日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号55回・11回・18回, 55回・11回・18回, 275 - 275, Japanese初診時に血管腫と鑑別を要した右下腿原発乳児線維肉腫の新生児例
- Oct. 2013, JBJS case connector, 3(4) (4), e120[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2013, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 152 - 152, Japanese全身静脈血サンプリングが診断に有用であった右手関節軟部腫瘍による腫瘍性骨軟化症の1例
- Sep. 2013, INTERNATIONAL JOURNAL OF ONCOLOGY, 43(3) (3), 703 - 712, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1473 - S1473, Japaneseヒト悪性線維性組織球腫細胞株におけるsurvivin抑制によるアポトーシスの検討
- Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial improvements in surgery and chemotherapy, metastasis remains a major cause of fatal outcomes, and the molecular mechanisms of metastasis are still poorly understood. Hypoxia, which is common in malignant tumors including osteosarcoma, increases expressions of hypoxia inducible factor (HIF)-1α, matrix metalloproteinase (MMP)-2 and MMP-9, and can induce invasiveness. As we previously showed a novel transcutaneous CO2 application to decrease HIF-1α expression and induce apoptosis in malignant fibrous histiocytoma, we hypothesize that transcutaneous CO2 application could suppress metastatic potential of osteosarcoma by improving hypoxic conditions. Here, we examined the effects of transcutaneous CO2 application on apoptosis, and development of pulmonary metastasis using a highly metastatic osteosarcoma cell line, LM8. Transcutaneous CO2 application significantly decreased tumor growth and pulmonary metastasis in LM8 cells. Apoptotic activity increased, and intratumoral hypoxia was improved with decreased expressions of HIF-1α, MMP-2 and MMP-9, significantly, in the CO2-treated tumors. In conclusion, we found that transcutaneous CO2 application can induce tumor cell apoptosis and might suppress pulmonary metastasis by improvement of hypoxic conditions with decreased expressions of HIF-1α and MMPs in highly metastatic osteosarcoma cell. These findings strongly indicate that this novel transcutaneous CO2 therapy could be a therapeutic breakthrough for osteosarcoma patients.Aug. 2013, Experimental cell research, 319(13) (13), 1988 - 97, English, International magazine[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1111 - S1111, JapaneseResearch society
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1169 - S1169, Japanese足根骨に発生した骨巨細胞腫の1例
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1242 - S1242, Japanese高純度β-リン酸三カルシウム(β-TCP)を骨補填材料として使用した良性骨腫瘍の治療成績
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1106 - S1106, JapaneseSurvivinの発現抑制はMFH細胞においてミトコンドリアを介したアポトーシスを亢進させる
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1109 - S1109, JapaneseDcR3はPI3K/Akt経路を介したMMP-2発現制御によりMFH細胞の遊走能、浸潤能を亢進させる
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361, Japanese乳癌細胞株を移植した動物モデルに対する経皮的炭酸ガス治療の効果
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S409, Japanese大腿切断後の断端shrinkageに対し従来の吸着式ソケットにより良好な成績を得た1例
- May 2013, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361, Japanese骨肉腫肺転移マウスモデルに対する経皮炭酸ガス療法の効果の検討
- (株)医学書院, Apr. 2013, 臨床整形外科, 48(4) (4), 429 - 432, Japanese[Refereed]
- (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S323 - S323, Japanese炭酸ガス経皮投与は骨肉腫細胞の腫瘍増大と転移能を抑制する
- (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S720 - S720, JapaneseResearch society
- Magnetic resonance imaging (MRI) plays an important role in the diagnosis of osteomyelitis, especially during the early phase of the disease. The findings of sequential MRIs during the course of treatment in acute osteomyelitis in children have not yet been reported in the literature. We present a case of acute epiphyseal osteomyelitis in the distal femur of an infant. We monitored imaging changes by sequential MRIs and radiographs. MRI was more useful than radiograph for early diagnosis and evaluation of therapeutic response.2013, Case reports in radiology, 2013, 672815 - 672815, English, International magazine[Refereed]Scientific journal
- Nov. 2012, PLOS ONE, 7(11) (11), English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 175 - 175, Japanese血管柄付腓骨移植を用いて再建した足根骨骨巨細胞腫の一例[Refereed]
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, Japanese炭酸ガス経皮投与療法を用いた骨・軟部肉腫に対する新しい治療法[Refereed]
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1313 - S1313, Japanese炭酸ガス経皮投与はMMP群の発現を抑制することで骨肉腫細胞の肺転移能を低下させる[Refereed]
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, Japaneseミトコンドリア量調節による悪性骨・軟部腫瘍に対する治療の可能性[Refereed]
- (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1380 - S1380, JapaneseヒトMFH細胞におけるDcR3の増殖能・遊走能・浸潤能に対する影響の検討[Refereed]
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S810 - S810, Japanese腓骨骨腫瘍の1例[Refereed]
- (一社)日本移植学会, Jun. 2012, 移植, 47(2-3) (2-3), 246 - 246, Japanese良性骨腫瘍切除後骨欠損に対する高純度β-リン酸三カルシウム(β-TCP)充填の治療成績
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S969 - S969, Japanese低酸素環境の改善はヒトMFH細胞においてミトコンドリア量を増加させる[Refereed]
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S954 - S954, Japanese炭酸ガス経皮投与療法を用いたヒトMFHに対する新しい治療法[Refereed]
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S823 - S823, Japanese体幹部(脊椎を除く)悪性骨・軟部腫瘍への治療戦略 体幹部に発生した悪性軟部腫瘍に対する治療成績[Refereed]
- Jun. 2012, INTERNATIONAL JOURNAL OF ONCOLOGY, 40(6) (6), 1839 - 1848, English[Refereed]Scientific journal
- Jun. 2012, RHEUMATOLOGY INTERNATIONAL, 32(6) (6), 1691 - 1694, EnglishScientific journal
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S970 - S970, JapaneseDcR3はMMP発現を介してヒトMFH細胞の遊走能および浸潤能を制御する[Refereed]
- (一社)日本小児血液・がん学会, May 2012, 日本小児血液・がん学会雑誌, 49(1-2) (1-2), 115 - 120, Japaneseタンデム自家造血細胞移植併用大量化学療法を施行後3年寛解を維持している初診時全身骨髄転移陽性Ewing肉腫ファミリー腫瘍の1例[Refereed]
- Apr. 2012, JOURNAL OF SHOULDER AND ELBOW SURGERY, 21(4) (4), E1 - E4, English[Refereed]Scientific journal
- (一社)中部日本整形外科災害外科学会, Apr. 2012, 中部日本整形外科災害外科学会雑誌, 55(春季学会) (春季学会), 139 - 139, Japanese胸壁発生の悪性軟部腫瘍に対する治療成績[Refereed]
- (公社)日本整形外科学会, Mar. 2012, 日本整形外科学会雑誌, 86(3) (3), S545 - S545, JapaneseDcR3発現抑制はMFH細胞において細胞遊走能および浸潤能を抑制し、FasLによるアポトーシスを亢進させる[Refereed]
- 2012, Journal of Cancer Science and Therapy, 4(7) (7), 3, English[Refereed]Scientific journal
- 2012, Open Journal of Pathology, 2, 90 - 95, EnglishDedifferentiated chondrosarcoma with a high-grade mesenchymal component mimicking a gastrointestinal stromal tumor[Refereed]Scientific journal
- Nov. 2011, ONCOLOGY REPORTS, 26(5) (5), 1221 - 1226, English[Refereed]Scientific journal
- Nov. 2010, UPSALA JOURNAL OF MEDICAL SCIENCES, 115(4) (4), 291 - 296, English[Refereed]Scientific journal
- Sep. 2010, Anticancer Research, 30(9) (9), 3391 - 3395, English, International magazineThe effect of bevacizumab on tumour growth of malignant fibrous histiocytoma in an animal model[Refereed]Scientific journal
- Jul. 2009, APPLIED RADIATION AND ISOTOPES, 67(7-8) (7-8), S355 - S358, English[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2008, 日本整形外科学会雑誌, 82(6) (6), S777 - S777, Japaneseガドリニウム中性子捕捉療法を目指したMRIによる腫瘍細胞株へのMRI造影剤の付着取り込みの評価について
- Mar. 2008, Clinical Imaging, 32(2) (2), 147 - 151[Refereed]Scientific journal
- Mar. 2008, Skeletal Radiology, 37(3) (3), 263 - 265, English, International magazine[Refereed]Scientific journal
- Mar. 2008, ANTICANCER RESEARCH, 28(2A) (2A), 825 - 832, EnglishInhibition of PKCa activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412[Refereed]Scientific journal
- Jan. 2007, Anticancer Research, 27(1 A) (1 A), 423 - 430Imatinib mesylate inhibits tumorigenicity of malignant fibrous histiocytoma cells in vivo[Refereed]Scientific journal
- Nov. 2006, Anticancer Research, 26(6 B) (6 B), 4307 - 4311Expression of VEGF and its receptors and angiogenesis in bone and soft tissue tumors[Refereed]Scientific journal
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S694 - S694, JapaneseプロテインキナーゼインヒビターPKC412のヒト骨・軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討[Refereed]
- Mar. 2006, 中部日本整形外科災害外科学会雑誌, 49巻, 春季学会, pp.175-175(6) (6), Japanese骨巨細胞腫の治療成績
- (一社)中部日本整形外科災害外科学会, Nov. 2005, 中部日本整形外科災害外科学会雑誌, 48(6) (6), 1092 - 1092, Japanese正中神経に発生したplexiform schwannomaの1例International conference proceedings
- (公社)日本整形外科学会, Aug. 2005, 日本整形外科学会雑誌, 79(8) (8), S818 - S818, Japanese骨軟部腫瘍におけるVEGF受容体の発現
- (公社)日本整形外科学会, Aug. 2005, 日本整形外科学会雑誌, 79(8) (8), S895 - S895, JapaneseプロテインキナーゼインヒビターPKC412のヒト骨軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S560 - S560, JapaneseInternational conference proceedings
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S611 - S611, Japanese上腕二頭筋長頭腱内ガングリオンの1例
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S704 - S704, JapaneseMRI造影剤のヒト腫瘍細胞株への影響について
- (公社)日本整形外科学会, Mar. 2005, 日本整形外科学会雑誌, 79(3) (3), S193 - S193, Japanese脂肪肉腫の治療成績
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2004, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 47(6) (6), 1211 - 1212, Japanese
- 2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)Ewing肉腫の病態解明と新規治療標的の探索-次世代シーケンサーを用いた網羅的遺伝子解析によるSlow-Cycling Cellsの検討-
- 2025, 日本整形外科学会雑誌(CD-ROM), 99(3) (3)Compress型インプラントを用いた腫瘍用人工関節置換術例の検討
- 2025, 中部日本整形外科災害外科学会雑誌, 68透析患者の異所性石灰化に伴う病的骨折に対して腫瘍用インプラントを用いて治療を行った一例
- 2025, 中部日本整形外科災害外科学会雑誌, 68上肢骨転移に対する手術成績
- 三輪書店, 25 Dec. 2024, 脊椎脊髄ジャーナル, 37(10) (10), 863 - 870
- 東京 : 全日本病院出版会, Jul. 2024, Monthly book medical rehabilitation, (302) (302), 49 - 54, Japaneseがんロコモに対するリハビリテーション治療 : 四肢骨転移に対する整形外科的治療の適応と安静度設定—特集 がんロコモ : がん患者の運動器管理とリハビリテーション診療
- 2024, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- 2024, Japanese Journal of Rehabilitation Medicine (Web), 61(Autumn) (Autumn)小児悪性骨軟部腫瘍下肢切断術後の化学療法と並行した義足リハビリテーション治療の経験
- 2024, 日本病院総合診療医学会雑誌(Web), 20多診療科で連携し加療した妊娠中期の食道癌多発転移の1例
- 2024, 日本整形外科学会雑誌(CD-ROM), 98(6) (6)中高齢者高悪性度悪性骨腫瘍に対する補助化学療法の至適レジメンについての検討(JMOG044後ろ向き研究)
- 株式会社医学書院, 25 Dec. 2023, 臨床整形外科, 58(12) (12), 1481 - 1486
- 東京 : 医学書院, Dec. 2023, 臨床整形外科, 58(12) (12), 1481 - 1486, Japanese整形外科医が骨修飾薬を活用するために知っておきたいこと—Bone-Modifying Agents for Bone Metastasis—特集 がん時代の整形外科必携! 骨転移診療アップデート ; 骨転移集学的治療各論
- 公益社団法人 日本リハビリテーション医学会, 18 Jun. 2023, 60(6) (6), 464 - 464, Japanese
- 2023, 日本がんリハビリテーション研究会プログラム・抄録集, 11th骨転移キャンサーボードを用いた骨転移患者のQOL変化の調査
- 金原出版, 01 Mar. 2022, 整形・災害外科, 65(3) (3), 303 - 310
- 東京 : 金原出版, Mar. 2022, 整形・災害外科 = Orthopaedic surgery and traumatology, 65(3) (3), 303 - 310, Japanese進行期軟部肉腫に対する緩和医療—Palliative care in advanced soft tissue sarcoma—特集 軟部肉腫の治療update
- 2022, PEPARS, (181) (181)まずはここから!四肢のしこり診療ガイド 筋増殖疾患,筋原性腫瘍
- 2022, がん治療における緩和的放射線治療の評価と普及啓発のための研究 令和3年度 総括・分担研究報告書(Web)がん治療における緩和的放射線治療の評価と普及啓発のための研究 骨転移キャンサーボードの推進に関する研究
- 2021, 日本整形外科学会雑誌, 95(8) (8)乳癌骨転移による骨破壊に寄与するmiRNAの検討
- 2021, 中部日本整形外科災害外科学会雑誌, 64(1) (1)The treatment of metastatic bone tumor of the acetabulum with bone cement and screw fixation: case report
- 2021, 中部日本整形外科災害外科学会雑誌, 64肩関節周囲に生じた巨大な結節性偽痛風の1例
- (株)日本臨床社, Oct. 2020, 日本臨床, 78(増刊5 肉腫) (増刊5 肉腫), 310 - 314, Japanese【肉腫-基礎・臨床の最新知見-】肉腫の外科的治療 切除 In situ preparation
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1856 - S1856, JapaneseEwing肉腫におけるcellular dormancyの同定とその特性の探索
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1861 - S1861, Japanese乳癌骨転移における骨破壊に寄与するmiRNAの探索
- (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1982 - S1982, Japanese遺伝子導入による人工骨肉腫幹細胞株の樹立
- (NPO)日本緩和医療学会, Aug. 2020, Palliative Care Research, 15(Suppl.) (Suppl.), S71 - S71, Japaneseがんロコモ 緩和ケアとがんロコモ
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 130 - 130, Japanese骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療
- (公社)日本リハビリテーション医学会, Jul. 2020, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 2, Japanese頸椎転移患者の手術成績と成績不良因子の検討 PS、QOLの推移から
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1424 - S1424, Japanese転移性孤在性線維性腫瘍の治療成績に関する多施設共同研究 JMOG研究
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1449 - S1449, Japanese滑膜肉腫の治療成績
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1525 - S1525, Japanese骨肉腫細胞における特定因子導入を用いたがん幹細胞特性の獲得
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1546 - S1546, Japaneseがん骨転移における骨破壊に寄与するmiRNAの探索
- (公社)日本整形外科学会, Jul. 2020, 日本整形外科学会雑誌, 94(6) (6), S1548 - S1548, Japanese骨・軟部肉腫による脳転移例の検討
- がん患者の運動器障害「がんロコモ」に対して整形外科医が積極的かつ包括的にかかわっていくことは,がん患者のADL,QOLの維持・向上を目的とし,がん患者が最期まで人間らしく生きることを支援することである.そのために,がん患者の運動器障害の原因を特定し,評価し,適切な治療を行う必要がある.がんの診断から終末期まで,がん患者の運動機能の低下を最小限にすることが整形外科医の役割である.骨転移を含めたがんロコモ対策にはチーム医療が必要である.The Japanese Association of Rehabilitation Medicine, 17 Apr. 2020, The Japanese Journal of Rehabilitation Medicine, 57(4) (4), 305 - 310, Japanese
- (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 240 - 240, Japanese前腕に発生した悪性グロームス腫瘍の1例
- (公社)日本リハビリテーション医学会, Apr. 2020, The Japanese Journal of Rehabilitation Medicine, 57(4) (4), 305 - 310, Japanese
- (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S338 - S338, Japanese悪性軟部腫瘍肺転移に対する肺転移切除の意義
- (株)全日本病院出版会, Jan. 2020, Orthopaedics, 33(1) (1), 81 - 89, Japanese【大腿骨近位部骨折の治療-今、何が議論されているのか?-】大腿骨近位部骨転移の治療戦略 骨接合か?近位置換か?
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1679 - S1679, Japanese
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1957 - S1957, Japaneseがん骨転移における骨破壊に寄与するmiRNAの同定
- (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 234 - 234, Japanese発熱性好中球減少症と鑑別を要したG‐CSF投与による大動脈炎の1例
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1679 - S1679, Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立とその特性の探索
- (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1957 - S1957, Japaneseがん骨転移における骨破壊に寄与するmiRNAの同定
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1350 - S1350, Japanese右足部軟部腫瘍の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1361 - S1361, Japanese骨巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1368 - S1368, Japanese手指、足趾発生の腱鞘巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1373 - S1373, JapaneseWait & see policyで初回治療を行った腹腔外デスモイド型線維腫症の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1422 - S1422, Japanese明細胞肉腫に対するLAT1阻害剤の抗腫瘍効果の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1485 - S1485, Japanese骨肉腫に対する徐放化抗癌剤抱合血管内皮前駆細胞を用いた新規がん治療法の開発
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1497 - S1497, Japanese粘液型脂肪肉腫の治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1514 - S1514, Japanese坐骨神経近傍に発生した悪性筋上皮腫の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1516 - S1516, Japanese骨・軟部肉腫における脳転移症例の検討
- 日本運動器科学会, Jun. 2019, 運動器リハビリテーション, 30(2) (2), 179 - 179, Japanese大腿骨近位部病的骨折 人工関節の適応と限界
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1350 - S1350, Japanese右足部軟部腫瘍の1例
- 日本運動器科学会, Jun. 2019, 運動器リハビリテーション, 30(2) (2), 179 - 179, Japanese大腿骨近位部病的骨折:人工関節の適応と限界
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1361 - S1361, Japanese骨巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1485 - S1485, Japanese骨肉腫に対する徐放化抗癌剤抱合血管内皮前駆細胞を用いた新規がん治療法の開発
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1368 - S1368, Japanese手指,足趾発生の腱鞘巨細胞腫に対する治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1373 - S1373, JapaneseWait & see policyで初回治療を行った腹腔外デスモイド型線維腫症の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1422 - S1422, Japanese明細胞肉腫に対するLAT1阻害剤の抗腫瘍効果の検討
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1416 - S1416, Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1497 - S1497, Japanese粘液型脂肪肉腫の治療成績
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1514 - S1514, Japanese坐骨神経近傍に発生した悪性筋上皮腫の1例
- (公社)日本整形外科学会, Jun. 2019, 日本整形外科学会雑誌, 93(6) (6), S1516 - S1516, Japanese骨・軟部肉腫における脳転移症例の検討
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 595 - 595, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 599 - 600, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 9, English四肢転移性骨腫瘍に対する外科的治療成績について
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 9, Japaneseがんの骨転移症例に対するリハビリテーション医療の現状と症例検討
- (一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 595 - 595, Japanese膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した1例
- 9歳男児。主訴は右膝関節痛で、鎮痛剤投与で一旦改善したが4週間後再燃し、X線像にて右大腿骨内顆に10mm大の骨透亮像、CT像では右大腿骨内顆後方に骨皮質の欠損を認めた。MRIではT1強調像で4層の異常信号領域を伴うpenumbla signを認め、右膝関節穿刺液の細胞診では好中球主体の炎症性細胞を多数認めた。骨髄炎が軟骨下骨を穿破し化膿性膝関節炎を合併したと診断し、初診日から3日目より1ヵ月間cefazolin点滴投与を開始し、初診日から7日目に手術を施行し、病巣掻爬、抗生剤入り人工骨充填、大腿筋膜によるパッチ被覆を行った。術後10日目よりSulfamethoxazole/Trimethoprimを6週間追加し、術後1年のCT像では病巣掻爬部の軟骨下骨の再生を認めた。術後4年のMRIでは関節軟骨様組織の再生所見が確認でき、術後8年目のMRIでも関節軟骨様組織の連続性は保たれ膝の可動域制限も認めず経過良好である。(一社)中部日本整形外科災害外科学会, May 2019, 中部日本整形外科災害外科学会雑誌, 62(3) (3), 599 - 600, Japanese
- (公社)日本リハビリテーション医学会, May 2019, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, English四肢転移性骨腫瘍に対する外科的治療成績について
- (一社)日本皮膚悪性腫瘍学会, Apr. 2019, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, 35回, 71 - 71, Japanese肉腫:診断から治療まで 軟部肉腫の診断と治療 整形外科骨軟部腫瘍専門医の経験と提言
- (一社)日本皮膚悪性腫瘍学会, Apr. 2019, 日本皮膚悪性腫瘍学会学術大会プログラム・抄録集, 35回, 71 - 71, Japanese肉腫:診断から治療まで 軟部肉腫の診断と治療 整形外科骨軟部腫瘍専門医の経験と提言
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 266 - 266, Japanese四肢の腎癌骨転移に対して手術を施行した症例の検討
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 184 - 184, JapaneseAcromioclavicular joint cystに対し手術加療を行った3症例
- (一社)日本脊椎脊髄病学会, Mar. 2019, Journal of Spine Research, 10(3) (3), 269 - 269, Japanese転移性脊椎腫瘍に対する手術加療の費用対効用を低下させる因子の検討
- (一社)日本脊椎脊髄病学会, Mar. 2019, Journal of Spine Research, 10(3) (3), 269 - 269, Japanese転移性脊椎腫瘍に対する手術加療の費用対効用を低下させる因子の検討
- (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 277 - 277, Japanese
- 2019, 日本再生医療学会総会(Web), 18th, ROMBUNNO.P‐01‐050 (WEB ONLY), Japaneseリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立
- THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2019, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 62(3) (3), 599 - 600, Japanese
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S274 - S274, Japanese70歳以上の脊椎転移患者の手術成績 PS、ADL、QOLの推移から
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S357 - S357, Japanese炭酸ガス経皮吸収による低酸素環境の改善が乳がん骨転移モデルの骨破壊を抑制する
- (公社)日本リハビリテーション医学会, Oct. 2018, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S367 - S367, Japanese脊椎転移の症候化リスク因子の前向き検討
- (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 121 - 121, Japanese後頸部に発症した良性対称性脂肪腫症の一例[Refereed]Meeting report
- (公社)日本整形外科学会, Jun. 2018, 日本整形外科学会雑誌, 92(6) (6), S1568 - S1568, Japanese初発転移が膵であった腓骨原発骨肉腫の1例[Refereed]Meeting report
- (一社)日本病理学会, Apr. 2018, 日本病理学会会誌, 107(1) (1), 452 - 452, Japanese異型多形脂肪腫様腫瘍と考えられた1例[Refereed]Meeting report
- (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 162 - 162, Japanese小児の手指に発生したchondrolipomaの1例[Refereed]Meeting report
- (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 78 - 78, Japanese転移性骨腫瘍に対する腫瘍用人工関節の術後成績
- (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 251 - 251, Japanese全身画像検索が診断に有用であった慢性再発性多発性骨髄炎(CRMO)の2例
- (株)全日本病院出版会, Sep. 2017, 整形外科最小侵襲手術ジャーナル, (84) (84), 79 - 83, Japanese【転移性脊椎腫瘍に対する最小侵襲脊椎安定術(MISt)】 転移性脊椎腫瘍に対する出張型骨転移Cancer Boardの取り組み[Refereed]Introduction scientific journal
- (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1707 - S1707, Japanese悪性骨・軟部腫瘍転移制御への道 炭酸ガス経皮吸収による低酸素環境の改善は乳癌骨転移による骨破壊を抑制する
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1394 - S1394, JapaneseLow-grade fibromyxoid sarcoma(Evans tumor)の診断におけるFISHの有用性
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1260 - S1260, Japanese悪性骨・軟部腫瘍に対する重粒子線治療の長期成績
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1323 - S1323, Japanese転移性骨腫瘍に対する腫瘍用人工関節の術後成績
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1324 - S1324, Japanese経皮炭酸ガス吸収による低酸素環境の改善はがん骨転移部の骨破壊を抑制する
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1358 - S1358, Japanese悪性軟部腫瘍肺転移に対する切除術の治療成績
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1408 - S1408, Japanese症候性脊椎転移の発生リスクに関する前向き研究
- (公社)日本整形外科学会, Jun. 2017, 日本整形外科学会雑誌, 91(6) (6), S1412 - S1412, Japanese四肢転移性骨腫瘍患者に対する理学療法の現状
- (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 145 - 145, Japanese大腿骨に発生したFGF23産生腫瘍による腫瘍性骨軟化症の1例
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S253 - S253, Japanese
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S260 - S260, JapaneseChronic expanding hematomaのMRI画像の特徴と軟部肉腫との鑑別についての検討
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S607 - S607, Japanese骨・軟部悪性腫瘍における肺転移切除例の治療成績
- (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(3) (3), S1058 - S1058, Japanese骨転移診療の現状と各診療科の意識調査 整形外科医・腫瘍内科医・放射線治療医に対するアンケート
- (一社)日本小児血液・がん学会, Nov. 2016, 日本小児血液・がん学会雑誌, 53(4) (4), 298 - 298, JapaneseG-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例
- (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 153 - 153, Japanese当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績
- (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 154 - 154, Japanese腸骨に発生したchronic expanding hematomaの1例
- (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1554 - S1554, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果
- (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1556 - S1556, Japanese骨肉腫細胞に対するSmac模倣薬とドキソルビシンの併用効果の検討
- (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1558 - S1558, Japanese骨転移部位の低酸素環境の改善は乳癌骨転移による骨破壊を抑制する
- (株)医学書院, Jul. 2016, 臨床整形外科, 51(7) (7), 601 - 605, Japanese[Invited]Introduction scientific journal
- (株)医学書院, Jul. 2016, 臨床整形外科, 51(7) (7), 644 - 646, Japanese最新基礎科学 知っておきたい 二酸化炭素の経皮吸収による悪性腫瘍の抗腫瘍効果[Invited]Introduction scientific journal
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1259 - S1259, Japanese
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1336 - S1336, JapaneseLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1181 - S1181, Japanese進行骨・軟部肉腫に対するゲムシタビン/ドセタキセル併用療法の治療成績
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1254 - S1254, Japanese骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1261 - S1261, Japanese低酸素環境改善は乳癌細胞において破骨細胞誘導因子と溶骨性因子の発現を低下させる
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1265 - S1265, Japanese悪性末梢神経鞘腫瘍(MPNST:malignant peripheral nerve sheath tumor)の治療成績
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1286 - S1286, Japanese脊椎転移に対する保存的治療と外科的治療 脊椎転移に対する手術療法の効果
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1293 - S1293, Japanese骨転移症例のリハビリ・緩和・在宅 当院における骨転移患者に対するリハビリテーション介入因子
- (公社)日本整形外科学会, Jun. 2016, 日本整形外科学会雑誌, 90(6) (6), S1245 - S1245, Japanese転移性脊椎腫瘍患者に対する理学療法の現状[Refereed]Meeting report
- (一社)日本脊椎脊髄病学会, Mar. 2016, Journal of Spine Research, 7(3) (3), 196 - 196, Japanese脊椎転移に対する集学的治療の予後改善効果
- (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 278 - 278, Japanese乳幼児に股関節義足を作成し歩行を獲得した一例
- (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S859 - S859, Japanese当院における四肢転移性骨腫瘍に対する外科的治療成績
- Feb. 2016, Journal of Clinical Rehabilitation, 25(2号) (2号), 131 - 139, Japanese【転移性骨腫瘍のリハビリテーション】 骨関連事象に対する集学的治療法[Refereed][Invited]Introduction scientific journal
- 2016, 日本小児血液・がん学会雑誌(Web), 53(4) (4)G-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例
- Nov. 2015, INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 93(3) (3), E481 - E481, EnglishSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesSummary international conference
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1802 - S1802, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果
- (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 282 - 282, Japanese後骨間神経麻痺を呈した前腕脂肪腫の一例Report scientific journal
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1803 - S1803, Japanese悪性腫瘍の炭酸ガス経皮吸収の感受性の差異の検討Meeting report
- (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1674 - S1674, Japanese骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1355 - S1355, Japanese脊椎転移に対する集学的治療の予後改善効果Meeting report
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1238 - S1238, JapaneseSurvivin抑制薬"YM155"は骨肉腫細胞において腫瘍増殖を抑制する
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1241 - S1241, JapaneseAICARの骨肉腫細胞に対するアポトーシス誘導効果
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1229 - S1229, Japanese悪性腫瘍に対する炭酸ガス経皮吸収の最適化投与条件の検討Meeting report
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1227 - S1227, Japanese骨肉腫細胞に対するSmac模倣薬とアドリアマイシンの併用効果
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1308 - S1308, Japanese骨巨細胞腫の治療成績
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1383 - S1383, Japanese軟部肉腫広範切除後皮膚欠損に対する遊離植皮における陰圧創傷閉鎖法併用の治療経験
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1293 - S1293, Japanese骨転移治療の院内連携 骨転移キャンサーボード(bone metastasis board:BMB)による転移性骨腫瘍のマネジメント
- (公社)日本整形外科学会, Jun. 2015, 日本整形外科学会雑誌, 89(6) (6), S1320 - S1320, Japanese当院における四肢転移性骨腫瘍に対する外科的治療成績
- May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S343, Japanese薬物による疼痛コントロールが困難であった腎細胞癌脛骨骨転移に対しPTB式免荷装具が有効であった1症例[Refereed]Meeting report
- (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S508 - S508, Japanese骨巨細胞腫の治療成績
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 486 - 486, JapaneseEuroQOL-5D(EQ-5D)を用いた転移性脊椎腫瘍に対する手術加療の費用対効用
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 518 - 518, Japanese高齢者脊椎転移に対する手術成績
- (一社)日本脊椎脊髄病学会, Mar. 2015, Journal of Spine Research, 6(3) (3), 640 - 640, Japanese骨転移専門tumor boardの取り組み
- 2015, Japanese Journal of Rehabilitation Medicine, 52当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組み-2年目を経過して-
- 2015, Japanese Journal of Rehabilitation Medicine, 52脊椎転移に対する集学的治療の治療成績
- (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S990 - S990, Japanese重粒子線治療後に局所再発を来した悪性骨・軟部腫瘍の検討
- (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1217 - S1217, Japanese遠隔転移を来した軟部肉腫の予後因子の解析
- 金原出版(株), Oct. 2012, 整形・災害外科, 55(11) (11), 1286 - 1287, Japanese分子レベルからみた整形外科疾患(シリーズIX) MFH細胞株に対する血管新生阻害剤bevacizumabの効果Introduction scientific journal
- (公社)日本整形外科学会, Jun. 2012, 日本整形外科学会雑誌, 86(6) (6), S877 - S877, Japanese脂肪肉腫の治療成績
- 2012, 日本小児整形外科学会雑誌, 21(3) (3)化膿性膝関節炎をきたした骨端部Brodie膿瘍の1例
- (一社)中部日本整形外科災害外科学会, Nov. 2011, 中部日本整形外科災害外科学会雑誌, 54(6) (6), 1315 - 1315, Japanese大腿切断後に断端神経腫を発症した1例
- Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S666 - S666, EnglishAnti-apoptotic Effect of Decoy Receptor 3 in Human Malignant Fibrous Histiocytoma CellsSummary international conference
- Sep. 2011, EUROPEAN JOURNAL OF CANCER, 47, S665 - S665, EnglishMitochondrial Proliferation Induces Apoptosis in Human MFH Cells by PGC-1alpha OverexpressionSummary international conference
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1260 - S1260, Japanese
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1261 - S1261, JapaneseProtein Kinase C-deltaのヒトMFH細胞に対するアポトーシスへの影響についての検討
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1320 - S1320, Japanese悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果
- (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1321 - S1321, JapanesePGC-1α過剰発現によるミトコンドリアの増殖はMFHにおいてアポトーシスを促進する
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S844 - S844, Japanese悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S851 - S851, Japanese悪性軟部腫瘍に対する追加広範囲切除の治療成績
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S891 - S891, Japanese術後に局所再発を来した軟部肉腫の検討
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S936 - S936, JapaneseProtein kinase D1は骨肉腫細胞においてMMP-2およびMMP-9の発現を制御して抗腫瘍効果を示す
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S937 - S937, JapaneseヒトMFH細胞株におけるprotein kinase C-deltaのアポトーシスへの影響についての検討
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S937 - S937, Japaneseヒト悪性線維性組織球腫細胞株におけるdecoy receptor 3の抗アポトーシス作用に関する検討
- (公社)日本整形外科学会, Jun. 2011, 日本整形外科学会雑誌, 85(6) (6), S943 - S943, JapaneseMFHに対するsurvivinを標的とした分子標的治療の可能性
- May 2011, ANNALS OF ONCOLOGY, 22, 29 - 29, EnglishPKD1 inhibits invasion and migration ability of osteosarcoma cells via modulating MMP-2 and-9Summary international conference
- May 2011, ANNALS OF ONCOLOGY, 22, 25 - 25, EnglishSurvivin is a potent therapeutic target of MFH cell growthSummary international conference
- 悪性骨腫瘍に伴う大腿骨病的骨折に対して創外固定術後に腫瘍用人工膝関節置換術を施行した就学児童の一症例 自立歩行獲得までの経緯【目的】<BR>近年、化学療法の進歩や優れた生体素材の開発により、四肢悪性腫瘍に対して患肢温存術が広く行われるようになってきている。大腿骨悪性腫瘍に対する患肢温存手術は広範囲切除により腫瘍に隣接する多くの正常組織ごと切除し、腫瘍用人工関節置換術が行われるため、術後の理学療法で機能獲得が困難となることも多い。この度、大腿骨病的骨折後、創外固定術の期間を経て、腫瘍用人工膝関節置換術を施行した就学児童に対して理学療法を行い、自立歩行獲得に難渋した一症例を経験したので文献的考察を加え報告する。<BR>【方法】<BR>症例は11歳男性。既往歴、家族歴に特記すべきことはなし。右大腿骨骨幹部病的骨折、大腿骨悪性腫瘍疑いにて他院より転院、入院3日目に切開生検術、大腿骨創外固定術を施行した。病理診断は骨肉腫であった。その後、術前化学療法4クールの後、入院後4ヶ月目に創外固定抜去し、右大腿骨広範囲腫瘍切除術(大腿骨遠位23cm及び外側広筋、内側広筋、中間広筋を切除)、腫瘍用人工膝関節置換術が行われた。その後、術後化学療法5クール、大量化学療法を実施した後、入院16ヶ月目に自宅退院となった。<BR>【説明と同意】<BR>本研究の目的、必要性を患者、家族に十分に説明し、同意を得た。<BR>【結果】<BR>創外固定術後4日目より、移乗訓練、筋力訓練より理学療法を開始した。創外固定中は股関節、足関節のストレッチ、ROMの拡大を目指して理学療法実施した。また、化学療法中の全身持久力低下の予防として、上肢のエルゴメーターで運動量の増大を図った。入院4ヶ月でのROMは右膝0°~30°、右足関節背屈10°(膝伸展位)、右SLR80°、MMTは右膝伸展2、右膝屈曲3、右股関節外転筋3、伸展筋3レベルであった。<BR>人工膝関節置換術後は術後4日目より理学療法再開となり、脚長差は2cm(Rt>Lt)であった。術後2ヵ月後よりリングロック付き膝装具を使用し、1/3PWBより荷重開始、5ヵ月後より1/2PWBとなった。理学療法は残存筋の筋力訓練、ROM訓練、荷重訓練、ADL訓練を中心に実施したが、化学療法中、骨髄抑制が生じ、隔離が必要な期間は、病棟で主に下肢の筋力訓練、膝関節のROM訓練を中心にself exerciseを指導した。退院時のROMは右膝0~30°、右足関節背屈10°(膝伸展位)、右SLR90°、MMTは右膝伸展2、右膝屈曲3、右股関節外転筋3、伸展筋4であった。退院前の患肢機能評価法(ISOLS)では18点(60%)、10m歩行速度は9.8秒であった。脚長差は2cm(Rt<Lt)となった。<BR>【考察】<BR>本症例の1つ目の問題はROM制限である。これは十分な広範切除が行われたことによる術後の痛み、筋力低下、術前創外固定の期間が4ヶ月程度あり、膝伸展位での期間が長かった事も影響して、膝蓋骨から創部にかけての皮膚、筋の癒着が非常に強かったことが相互に作用したものと思われる。また、化学療法中、CRPの上昇や、創部の熱感が強く、訓練中止せざるを得なかった期間が多かった影響もあると考えられる。一般的に腫瘍用人工膝関節置換術後は膝ROM屈曲90°を目標に訓練するが、本症例では膝伸展機構を大きく失っていること、ROM制限が強く、膝屈曲時に疼痛も強かったことから歩行時は膝関節完全伸展位での歩行を指導した。さらに、股関節周囲の筋力訓練、健側下肢や上肢による代償を主体としたADL指導を実施した結果、股関節伸展筋力が増加し、ロフストランド2本杖歩行で自立レベルに達した。階段昇降は2足1段揃え型で、また床からの立ち上がり、エスカレーターの乗り降りも可能となった。<BR>本症例のもうひとつの問題点は成長期にあることである。これに関しては、人工関節置換術後から退院まで健側下肢長が増加した影響で脚長差に変化が見られたが、退院時では姿勢異常は見られず、術側膝伸展位での歩行となり、脚長差の自覚もなかったため、補高等は施行しなかった。膝伸展位で固定することで、歩行の耐久性に課題は残るものの、歩行速度も上がり、安定し実用的な歩行を獲得できた。また、化学療法中も可能な限り理学療法介入することで16ヶ月という長期入院となったが、全身筋力、活動レベルを低下させることなく、自宅退院、復学を果たすことが出来た。<BR>【理学療法学研究としての意義】<BR>原発性悪性骨腫瘍に対する患肢温存術は若年例が多いため、患者の活動性も高いことが多い。理学療法としては、術前から術後に起こり得る機能障害を予測して代償機能の強化が重要で、本人の環境や活動性を考慮し、ADL指導や、環境整備といった多面的な関わりを持つことが重要であろう。また、本症例のように就学児童で長期入院を要する症例では、本人の理学療法に対する意欲を維持させる取り組みが必要であり、機能獲得に重要な意味を持つ。公益社団法人 日本理学療法士協会, Apr. 2011, 理学療法学, 38(Suppl.2) (Suppl.2), PI1 - 206, Japanese
- (一社)中部日本整形外科災害外科学会, Mar. 2011, 中部日本整形外科災害外科学会雑誌, 54(春季学会) (春季学会), 179 - 179, Japanese幼児の大腿骨骨端部骨髄炎の一例 X線、MR所見の経時的変化
- (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85(3) (3), S567 - S567, Japanese分化型脂肪肉腫の治療成績
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S111 - S111, JapaneseSurvivinはMFHに対する治療の標的になりうる
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S112 - S112, JapaneseSIRT1阻害による骨・軟部肉腫に対する細胞増殖抑制効果
- (公社)日本整形外科学会, Feb. 2011, 日本整形外科学会雑誌, 85(2) (2), S112 - S112, Japanese骨・軟部腫瘍におけるprotein kinase D1の発現についての検討
- (一社)中部日本整形外科災害外科学会, Sep. 2010, 中部日本整形外科災害外科学会雑誌, 53(秋季学会) (秋季学会), 39 - 39, Japanese後脛骨神経に発生したintraneural hemangiomaの1例
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1176 - S1176, Japanese骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1182 - S1182, Japaneseマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤ベバシズマブとドキソルビシンの併用療法の効果について
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1184 - S1184, Japanese骨・軟部悪性腫瘍におけるSIRT1の発現とその阻害による抗腫瘍効果
- (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1184 - S1184, Japanese骨・軟部腫瘍におけるprotein kinase D1の作用についての検討
- 上腕骨近位骨端部に発生したLangerhans cell hystiocytosisの1例8歳男児。患者は4ヵ月前よりの左肩痛で近医を受診、X線上で左上腕骨近位端に異常陰影が認められ、著者らの施設へ紹介となった。所見では左上腕骨近位部外側に圧痛と左肘からの介達痛がみられた。また、X線では左上腕骨近位骨端部に骨透亮像とわずかな骨硬化像が認められ、CTでは上腕骨頭後方に骨透亮像を認めた。一方、NRIではTIで筋肉に比しlowからiso intensity、T2でvery high intensityを呈しており、周囲に反応巣が認められた。更にGd造影では辺縁部は良く造影され、中心部に造影されない部分が確認されたが、骨シンチでは病変部や全身に有意な集積は認められなかった。確定診断目的に手術を行ったところ、術中迅速診断では悪性所見は否定的であり、病巣掻爬後、人工骨の移植が行なわれた。その結果、病理所見ではコーヒー豆様の切れ込みのある大型で長い核を有する組織球様細胞と好酸球やリンパ球の混在がみられたが、核異型は認めず、免疫染色はS-100、CD1aとも陽性であった。以上、これらことから本症例はLangerhans cell hystiocytosisと診断された。金原出版(株), Jul. 2010, 整形・災害外科, 53(8) (8), 1001 - 1005, Japanese
- (一社)中部日本整形外科災害外科学会, Jul. 2010, 中部日本整形外科災害外科学会雑誌, 53(4) (4), 973 - 974, Japanese下垂足で発症した神経内ガングリオンの1例
- Jun. 2010, EJC SUPPLEMENTS, 8(5) (5), 140 - 140, EnglishRole of protein kinase C delta in musculoskeletal tumoursSummary international conference
- Jun. 2010, EJC SUPPLEMENTS, 8(5) (5), 70 - 70, EnglishThe effect of bevacizumab on intratumoural angiogenesis of malignant fibrous histiocytoma in animal modelSummary international conference
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S850 - S850, Japanese悪性線維性組織球腫の治療成績
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S875 - S875, Japanese
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S924 - S924, Japanese悪性腫瘍と鑑別を要した肩甲背部に発生した骨化性筋炎の1例
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S952 - S952, Japanese悪性線維性組織球腫細胞株に対する血管新生阻害剤bevacizumabの効果
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S974 - S974, Japaneseマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤bevacizumabとdoxorubicinの併用療法の効果について
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S974 - S974, Japanese骨・軟部腫瘍におけるprotein kinase D1の発現についての検討
- (公社)日本整形外科学会, Jun. 2010, 日本整形外科学会雑誌, 84(6) (6), S989 - S989, Japanese腹壁外デスモイドの治療成績
- (一社)中部日本整形外科災害外科学会, Mar. 2010, 中部日本整形外科災害外科学会雑誌, 53(春季学会) (春季学会), 240 - 240, Japanese化膿性関節炎をきたした骨端部Brodie膿瘍の2例
- (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1247 - S1247, Japaneseマウス悪性線維性組織球腫(MFH)モデルにおける血管新生阻害剤bevacizumabの効果の検討
- (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1248 - S1248, JapaneseMFH細胞株に対する血管新生阻害剤bevacizumabの効果
- (公社)日本整形外科学会, Jun. 2009, 日本整形外科学会雑誌, 83(6) (6), S964 - S964, Japanese激烈な坐骨神経痛を呈しPETにより検出しえた坐骨神経内結節性筋膜炎の1例
- (一社)中部日本整形外科災害外科学会, Mar. 2009, 中部日本整形外科災害外科学会雑誌, 52(2) (2), 513 - 513, Japanese診断に難渋した左下肢痛の1例
- 2009, 日本整形外科学会雑誌, 83(6) (6)骨・軟部悪性腫瘍に対するsecond line化学療法としてのICE療法
- 2009, 日本整形外科学会雑誌, 83(6) (6)悪性軟部腫瘍MFHにおけるスフィンゴシンキナーゼの発現および細胞増殖への検討
- 2009, 日本整形外科学会雑誌, 83(6) (6)骨盤悪性腫瘍に対する重粒子線治療後の患肢機能評価
- 2009, 中部日本整形外科災害外科学会雑誌, 52(3) (3)上腕骨近位骨端部に発生したランゲルハンス細胞組織球症の1例
- 2009, 中部日本整形外科災害外科学会雑誌, 52高純度β-TCPを用いた良性骨腫瘍に対する術後成績
- 2009, 中部日本整形外科災害外科学会雑誌, 52悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例
- 2009, 日本整形外科学会雑誌, 83(6) (6)脱神経筋萎縮を伴った悪性末梢神経鞘腫瘍の2例
- 2009, Cancer Therapy, 7(ISSUE A) (ISSUE A), 43 - 48Expression of DcR3 in bone and soft tissue tumors[Refereed]
- 2008, 日本整形外科学会雑誌, 82(2) (2)悪性骨・軟部腫瘍におけるEDGレセプターおよびスフィンゴシンキナーゼ発現の検討
- 2008, 日本整形外科学会雑誌, 82(6) (6)骨盤悪性腫瘍に対する重粒子線治療の治療成績
- 2008, 日本整形外科学会雑誌, 82(8) (8)悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討
- 2008, 日本整形外科学会雑誌, 82(8) (8)血管新生阻害剤bevacizumabの悪性線維性組織球腫(MFH)に対するin vivoでの効果
- 2008, 日本整形外科学会雑誌, 82(6) (6)悪性骨・軟部腫瘍におけるEDGレセプターおよびスフィンゴシンキナーゼの発現の検討
- 2008, 日本整形外科学会雑誌, 82(6) (6)手に発生した結節性筋膜炎の1例
- 2008, 日本整形外科学会雑誌, 82(6) (6)骨・軟部腫瘍細胞株におけるsiRNAを用いたDcR3抑制効果
- 2008, 日本整形外科学会雑誌, 82(8) (8)骨・軟部腫瘍におけるDcR3の検討
- 2008, 日本整形外科学会雑誌, 82(6) (6)若年者骨・軟部悪性腫瘍に対する末梢血幹細胞移植を併用した超大量化学療法
- 2008, 中部日本整形外科災害外科学会雑誌, 51Benign Lipoblastomaの2例
- (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S704 - S704, Japanese骨・軟部腫瘍におけるDcR3の検討
- (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S801 - S801, JapaneseIn vitroでのMFHに対する血管新生阻害剤PTK787の効果
- (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S801 - S801, Japaneseヒト骨・軟部肉腫細胞株に対するRaf-1 Kinase Inhibitorによる抗腫瘍効果の検討
- 2007, 日本整形外科学会雑誌, 81(6) (6)骨盤腫瘍の1例
- 2007, 日本整形外科学会雑誌, 81(3) (3)孤立性骨嚢腫の治療成績
- 2007, 中部日本整形外科災害外科学会雑誌, 50当科における腱鞘巨細胞腫の治療成績
- 2007, 日本リウマチ・関節外科学会雑誌, 26(1) (1)Fibrous Hamartoma of Infancy: A Case Report
- 2007, 日本整形外科学会雑誌, 81(8) (8)MRIを用いたMRI造影剤の腫瘍細胞株における付着・取り込み特性の評価-ガドリニウム中性子捕捉療法を目指して-
- 2007, 日本整形外科学会雑誌, 81(6) (6)線維性骨異形成の治療成績
- 2007, 日本整形外科学会雑誌, 81(8) (8)MFH細胞株に対する血管新生阻害剤PTK787の効果
- 28歳男性。患者は右前腕部の軟部腫瘤と違和感を主訴とした。初診時、右前腕掌側に3×3cmの弾性硬の軟部腫瘤が触知され、MRI横断像では右前腕中央に正中神経の走行に一致してT1にて等〜低信号、T2にて高信号を示す腫瘤を認めた。また、冠状断像では同部位に径3cm大の円形腫瘍、その遠位に3個の小腫瘍を認めた。以上、これらの所見より、蔓状神経鞘腫が疑われ、腫瘍核出術を施行した結果、病理組織的に本症例は蔓状神経鞘腫と診断された。術後6ヵ月経過現在、再発および機能障害の残存は認めず、経過も良好である。(株)南江堂, Jan. 2007, 整形外科, 58(1) (1), 31 - 33, Japanese
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S696 - S696, Japanese骨・軟部腫瘍におけるVEGFと血管新生
- (公社)日本整形外科学会, Jun. 2006, 日本整形外科学会雑誌, 80(6) (6), S695 - S695, Japanese骨・軟部腫瘍におけるDcR3の検討
- 2006, 中部日本整形外科災害外科学会雑誌, 49骨巨細胞腫の治療成績
- 2006, 日本整形外科学会雑誌, 80(8) (8)骨髄間葉系細胞に対するMRI造影剤の影響
- 2006, 中部日本整形外科災害外科学会雑誌, 49MRIで偶然に発見された初期骨梗塞
- 2006, 日本整形外科学会雑誌, 80(8) (8)骨・軟部腫瘍におけるDcR3発現の検討
- 2006, 日本整形外科学会雑誌, 80(6) (6)MRI造影剤のイヌの骨髄間葉系細胞に対する影響について
- 2006, 日本整形外科学会雑誌, 80(8) (8)骨・軟部腫瘍におけるVEGFと血管新生
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S584 - S584, Japanese軟部MFHにおけるTransforming Growth Factor-βとその受容体の発現
- (公社)日本整形外科学会, Jun. 2005, 日本整形外科学会雑誌, 79(6) (6), S703 - S703, JapaneseプロテインキナーゼインヒビターPKC412のヒト骨軟部悪性腫瘍細胞株に対する細胞増殖阻害作用の検討
- 2005, 関節外科, 24(4) (4)Bilateral total knee arthroplasty for a patient with multiple Charcot like joint s:A case report
- 2005, 日本整形外科学会雑誌, 79(6) (6)悪性線維性組織球腫における炎症性サイトカイン発現の免疫組織化学的検討
- 2005, 日本整形外科学会雑誌, 79(6) (6)骨・軟部腫ようにおけるVEGF receptorの発現
- 2005, 日本整形外科学会雑誌, 79(6) (6)背部軟部腫ようの1例
- 2004, 臨床整形外科, 39(2) (2)Pycnogysostosis with Femoral Shaft Fracture : Case Report
- 2004, 日本脊椎脊髄病学会雑誌, 15(1) (1)頚椎脊柱管拡大術後のaxial symptomについて
- 2004, 中部日本整形外科災害外科学会雑誌, 47頚部脊柱管拡大術後のX線学的変化と術後成績について
- 2004, 中部日本整形外科災害外科学会雑誌, 47(6) (6)Postoperative radiographic and clinical evaluation of cervical laminoplasty
- 2004, 日本整形外科学会雑誌, 78(3) (3)腰椎椎間板ヘルニア手術の予測因子の解析
- 2003, 日本整形外科学会雑誌, 77(3) (3)全人工股関節置換術後脱臼のリスクファクター
- 2003, 関節外科, 22(5) (5), 644 - 647A case of brodie’s abscess resulting from Salmonella lingieres that traverse the epiphyseal plate.
- 2002, リウマチ, 42(2) (2)慢性関節リウマチにおけるTHA後の脱臼要因について
- 2001, 中部日本整形外科災害外科学会雑誌, 44(2) (2)骨端線を越えたBrodie骨膿ようの1例
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会遺伝子導入による人工骨肉腫幹細胞株の樹立
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会乳癌骨転移における骨破壊に寄与するmiRNAの探索
- 日本整形外科学会雑誌, Sep. 2020, Japanese, (公社)日本整形外科学会Ewing肉腫におけるcellular dormancyの同定とその特性の探索
- 日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, Japanese, (一社)日本インターベンショナルラジオロジー学会骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 転移性骨腫瘍に対する外科的治療
- Palliative Care Research, Aug. 2020, Japanese, (NPO)日本緩和医療学会がんロコモ 緩和ケアとがんロコモ
- 日本整形外科学会雑誌, Jul. 2020, Japanese, (公社)日本整形外科学会骨・軟部肉腫による脳転移例の検討
- 日本整形外科学会雑誌, Jul. 2020, Japanese, (公社)日本整形外科学会がん骨転移における骨破壊に寄与するmiRNAの探索
- 日本整形外科学会雑誌, Jul. 2020, Japanese, (公社)日本整形外科学会骨肉腫細胞における特定因子導入を用いたがん幹細胞特性の獲得
- 日本整形外科学会雑誌, Jul. 2020, Japanese, (公社)日本整形外科学会滑膜肉腫の治療成績
- 日本整形外科学会雑誌, Jul. 2020, Japanese, (公社)日本整形外科学会転移性孤在性線維性腫瘍の治療成績に関する多施設共同研究 JMOG研究
- The Japanese Journal of Rehabilitation Medicine, Jul. 2020, Japanese, (公社)日本リハビリテーション医学会頸椎転移患者の手術成績と成績不良因子の検討 PS、QOLの推移から
- 中部日本整形外科災害外科学会雑誌, Apr. 2020, Japanese, (一社)中部日本整形外科災害外科学会前腕に発生した悪性グロームス腫瘍の1例
- 日本整形外科学会雑誌, Mar. 2020, Japanese, (公社)日本整形外科学会悪性軟部腫瘍肺転移に対する肺転移切除の意義
- 第18回日本再生医療学会総会, Mar. 2019, Japanese, 神戸, Domestic conferenceリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- 第452回整形外科集談会京阪神地方会, Feb. 2019, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference膝関節軟骨穿破を伴ったBrodie膿瘍を長期経過観察した一例Oral presentation
- 第152回関西骨軟部腫瘍研究会, Feb. 2019, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference小児脛骨病変の1例Oral presentation
- 第2回日本サルコーマ治療研究学会学術集会, Feb. 2019, Japanese, 日本サルコーマ治療研究学会, 東京, Domestic conferenceリプログラミング因子を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceDevelopment of New Hybrid Treatment forOsteosarcoma Transplanting Controlled-Release Pirarubicin Conjugated Endothelial Progenitor CellPoster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceDevelopment of Induced Osteosarcoma Stem Cells Using Induced Pluripotent Stem (iPs) Cells Production TechnologyPoster presentation
- The 65th Annual Meeting of Orthopaedic Research Society, Feb. 2019, English, Orthopaedic Research Society, Austin, Domestic conferenceA Newly Developed Low Adhesive Scaffold Collagen (LASCol) Accelerates Bone Healing in a Rat Femur Osteotomy ModelPoster presentation
- 第151回関西骨軟部腫瘍研究会, Dec. 2018, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference大腿軟部腫瘍の1例Oral presentation
- 第2回日本リハビリテーション医学会秋季学術集会, Nov. 2018, Japanese, 日本リハビリテーション医学会, 仙台, Domestic conference脊椎転移の症候化リスク因子の前向き検討Oral presentation
- 2018 CTOS Annual Meeting, Nov. 2018, English, The Connective Tissue Oncology Society, Rome, International conferenceBenefit of surgical treatment for pulmonary metastasis in soft tissue sarcoma patients.Poster presentation
- 第2回日本リハビリテーション医学会秋季学術集会, Nov. 2018, Japanese, 日本リハビリテーション医学会, 仙台, Domestic conference70歳以上の脊椎転移患者の手術成績 -PS、ADL、QOLの推移から-Oral presentation
- 第9回兵庫県転移性骨腫瘍治療研究会, Oct. 2018, Japanese, 兵庫県転移性骨腫瘍治療研究会, 神戸, Domestic conference整形外科の介入が遅れた転移性骨腫瘍の2症例Oral presentation
- 第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conference新規低接着性scaffold collagen(LASCol)はラット骨欠損モデルにおいて骨癒合を促進するPoster presentation
- 第51回日本甲状腺外科学会学術集会, Oct. 2018, Japanese, 日本甲状腺外科学会, 横浜, Domestic conference甲状腺がんに対するレンバチニブ治療中の観血的処置の安全性に関する遡及的検討Oral presentation
- 第131回中部日本整形外科災害外科学会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 倉敷, Domestic conference後頸部に発症した良性対称性脂肪腫症の一例Oral presentation
- 第131回中部日本整形外科災害外科学会・学術集会, Oct. 2018, Japanese, 中部日本整形外科災害外科学会, 倉敷, Domestic conference後頚部に発症した良性対称性脂肪腫症の一例Oral presentation
- 第33回日本整形外科学会基礎学術集会, Oct. 2018, Japanese, 日本整形外科学会, 奈良, Domestic conferenceiPS作製技術を用いた人工骨肉腫幹細胞株の樹立Poster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference不安定性を有する転移性脊椎腫瘍に対する治療 脊椎転移に対する手術療法の効果Public symposium
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference粘液線維肉腫の治療成績Poster presentation
- 第44回日本骨折治療学会, Jul. 2018, Japanese, 日本骨折治療学会, 岡山, Domestic conference大腿骨近位部病的骨折の治療戦略 大腿骨近位部病的骨折 人工関節の適応と限界Nominated symposium
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference脊椎転移に対する手術療法の効果Oral presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference初発転移が膵であった腓骨原発骨肉腫の1例Poster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference四肢の腎癌骨転移に対して手術を施行した症例の検討Oral presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conference経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制するPoster presentation
- 第51回日本整形外科骨・軟部腫瘍学術集会, Jul. 2018, Japanese, 日本整形外科学会, 静岡, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFISHの有用性Oral presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference当院における骨転移リハビリテーションの現状と症例の検討Oral presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference新規低接着性コラーゲン(LASCol)はラット大腿骨骨欠損モデルにおいて骨癒合を促進するPoster presentation
- 第55回日本リハビリテーション医学会学術集会, Jun. 2018, Japanese, 日本リハビリテーション医学会, 福岡, Domestic conference経皮炭酸ガス吸収による低酸素環境の改善は乳癌骨転移モデルの骨破壊を抑制できるPoster presentation
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学会, 神戸, Domestic conference悪性軟部腫瘍肺転移症例における予後因子Poster presentation
- 第91回日本整形外科学術総会, May 2018, Japanese, 日本整形外科学科, 神戸, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討 診断におけるFUS break-apart FISHの有用性Oral presentation
- 第47回日本脊椎脊髄病学会学術集会, Apr. 2018, Japanese, 日本脊椎脊髄病学会学術集会, 神戸, Domestic conference脊椎転移に対する集学的治療は予後を延長させるOral presentation
- 第47回日本脊椎脊髄病学会, Apr. 2018, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference脊椎転移に対する集学的治療は予後を延長させるOral presentation
- 第130回中部日本整形外科災害外科学会, Apr. 2018, Japanese, 中部日本整形外科災害外科学会, 松山, Domestic conference小児の手指に発生したchondrolipomaの1例Oral presentation
- 第8回兵庫県転移性骨腫瘍治療研究会, Mar. 2018, Japanese, 兵庫県転移性骨腫瘍治療研究会, 神戸, Domestic conference腎癌の転移性骨腫瘍に対しニボルマブが著効した一例Oral presentation
- The 64th Annual Meeting of the Orthopaedic Research Society, Mar. 2018, English, The Orthopaedic Research Society, New Orleans, USA, International conferenceAugmentation of Fracture Healing by Low Adhesive Scaffold Collagen (LASCol) in a Rat Femur Osteotomy Model.Poster presentation
- 第149回関西骨軟部腫瘍研究会, Feb. 2018, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- 15th Japan-Korea Joint Slide Conference of International Academy of Pathology (IAP), Dec. 2017, English, Japan Division of IAP, 神戸市, International conferenceSoft tissue tumor in the back of the neckOral presentation
- 第148回関西骨軟部腫瘍研究会, Nov. 2017, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference手部軟部腫瘍の1例Oral presentation
- 第59回日本小児血液・がん学会, Nov. 2017, Japanese, 日本小児血液・がん学会, 愛媛, Domestic conferenceClinical characteristics and outcome of pediatric osteosarcoma: a single-center experienceOral presentation
- 第1回日本リハビリテーション医学会秋季学術集会, Oct. 2017, Japanese, 日本リハビリテーション医学会, 岡山, Domestic conference当院における骨転移リハビリテーションの現状とリハ介入因子の検討Oral presentation
- 第7回兵庫県転移性骨腫瘍治療研究会, Oct. 2017, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference転移性骨腫瘍に対する人工骨幹置換術Oral presentation
- The 129th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, Domestic conference転移性骨腫瘍に対する腫瘍用人工関節の術後成績[Invited]Nominated symposium
- The 32nd Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2017, Japanese, The Japanese Orthopaedic Association, 沖縄, Domestic conferenceThe improvement of hypoxia by Transcutaneous Carbon Dioxide (CO2) Application blocks the progressive bone destruction in breast cancer metastasis[Invited]Nominated symposium
- The 129th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 富山, Domestic conference全身画像検索が診断に有用であった慢性再発性多発性骨髄炎(CRMO)の2例Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference転移性骨腫瘍に対する腫瘍用人工関節の術後成績Poster presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference症候性脊椎転移の発生リスクに関する前向き研究Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference四肢転移性骨腫瘍患者に対する理学療法の現状Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceThe Improvement of Hypoxia by Transcutaneous CO2 Application Blocks The Bone Destruction in Metastatic Bone TumorPoster presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference悪性軟部腫瘍肺転移に対する切除術の治療成績Oral presentation
- The 50th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2017, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の 診断におけるFISHの有用性Oral presentation
- The 54th Annual Meeting of the Japanese Association of Rehabilitation Medicine, Jun. 2017, Japanese, The International Congress of Shoulder & Elbow Surgery, 岡山, Domestic conference骨盤骨腫瘍に対して腫瘍切除後にHip transposition法を施行した2例Oral presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference骨軟部悪性腫瘍における肺転移切除例の治療成績Poster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conference骨転移診療の現状と各診療科の意識調査 整形外科医・腫瘍内科医・放射線治療医に対するアンケートOral presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceThe Improvement of Hypoxia by Transcutaneous CO2 Application Blocks The Progression of Bone Destruction in Bone Metastatic Animal Model.Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceOutcomes of tumor endoprosthetic reconstruction after resection of bone metastasis.Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, Kanazawa, Japan, International conferenceOptimaization of Anti-tumor Treatment Conditions for Transcutaneous CO2 Application in vivoPoster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の診断における分子遺伝学的解析の有用性Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceClinicopathological investigation and diagnostic algorithm for low-grade fibromyxoid sarcoma (Evans tumor)Poster presentation
- The 90th Annual Meetin of the Japanese Orthopaedic Association, May 2017, Japanese, The Japanese Orthopaedic Association, 仙台, Domestic conferenceChronic expanding hematomaのMRI画像の特徴と軟部肉腫との鑑別についての検討Poster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceBenefit of surgical treatment of pulmonary metastasis in bone and soft tissue sarcomaPoster presentation
- The 19th International Society of Limb Salvage General Meeting, May 2017, English, International Society of Limb Salvage General Meeting, 金沢, International conferenceActivation of AMPK by AICAR suppresses osteosarcoma cell growth via induction of mitochondrial apoptosisOral presentation
- The 128th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2017, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 神戸, Domestic conference大腿骨に発生したFGF23産生腫瘍による腫瘍性骨軟化症の1例Oral presentation
- ISMRM 25th Annual Meeting & Exhibition, Apr. 2017, English, international Society for Magnetic Resonance in Medicine, Honolulu, USA, In patients with normal renal function, typical linear Gd chelate, Gd-DTPA-BMA showed approximately 5.0 times more Gd accumulation in the human bone than macrocyclic Gd chelate, Gd-DOTA at a single dose application., International conferenceComparison of gadodiamide (Gd-DTPA-BMA) versus gadoterate meglumine (Gd-DOTA) of Gadolinium retention in human bone tissue in relation with renal functionOral presentation
- 第6回兵庫県転移性骨腫瘍治療研究会, Mar. 2017, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference大腿骨非定型骨折を来した乳癌の転移性骨腫瘍Oral presentation
- 第146回関西骨軟部腫瘍研究会, Feb. 2017, Japanese, Kansai Musculoskeletal Tumor Seminar, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- Advanced Breast Cancer seminar, Jan. 2017, Japanese, Advanced Breast Cancer seminar, 博多, Domestic conference当院における転移性骨腫横に対する取り組み -BMB(キャンサーボード)設立から4年-Public discourse
- 第58回日本小児血液・がん学会学術集会, Dec. 2016, Japanese, 日本小児血液・がん学会, 東京, Domestic conferenceG-CSF投与と自家末梢血幹細胞移植を併用しbi-weekly VDC-IE療法を完遂し得た切除不能ユーイング肉腫例Oral presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conference骨肉腫細胞に対するSmac模倣薬とドキソルビシンの併用効果の検討Poster presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conference骨転移部位の低酸素環境の改善は乳癌骨転移による骨破壊を抑制するPoster presentation
- 2016 Connective Tissue Oncology Society Annual Meeting, Nov. 2016, English, Connective Tissue Oncology Socisty, Lisbon, Portugal, International conferenceClinicopathological investigation of low-grade fibromyxoid sarcoma (Evans tumor)Poster presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Nov. 2016, Japanese, The Japanese Orthopaedic Association, 博多, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Oral presentation
- 第5回兵庫転移性骨腫瘍治療研究会, Oct. 2016, Japanese, Hyogo Metastatic Bone Tumor Seminar, 神戸, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績Oral presentation
- The 31st Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2016, Japanese, The Japanese Orthopaedic Association, 福岡, Domestic conference骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討Oral presentation
- The 127th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Sep. 2016, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 松本, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療の現状と治療成績Oral presentation
- The 127th Meeting of The Central Japan Association of Orthopaedic Surgery and Traumatology, Sep. 2016, Japanese, Meeting of The Central Japan Association of Orthopaedic Surgery, 松本, Domestic conference腸骨に発生したchronic expanding hematomaの1例Oral presentation
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association., Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference当院における転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference当院における骨転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference転移性脊椎腫瘍患者に対する理学療法の現状Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference低酸素環境改善は乳癌細胞において破骨細胞誘導因子と溶骨性因子の発現を低下させるPoster presentation
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference脊椎転移に対する保存的治療と外科的治療 脊椎転移に対する手術療法の効果[Invited]Nominated symposium
- The 49th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference脊椎転移に対する手術療法の効果[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference進行骨軟部肉腫に対するゲムシタビン/ドセタキセル併用療法の治療成績Oral presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference骨肉腫細胞に対するSmac模倣薬と抗癌剤の併用効果の検討Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference骨転移症例のリハビリ・緩和・在宅 当院における骨転移患者に対するリハビリテーション介入因子[Invited]Nominated symposium
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conference悪性末梢神経鞘腫瘍(MPNST: malignant peripheral nerve sheath tumor)の治療成績.Poster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceLow-grade fibromyxoid sarcoma(Evans tumor)の臨床病理学的検討Oral presentation
- 第49回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2016, Japanese, 日本整形外科学会, 東京都, Domestic conferenceLow-grade fibromyxoid sarcoma (Evans tumor)の臨床病理学的解析Oral presentation
- 2016 the Japanese Society of Medicla Oncology Annual Meeting, Jul. 2016, English, The Japanese Society of Medical Oncology, 神戸, Domestic conferenceGemcitabine and docetaxel for advanced bone and soft tissue sarcomasPoster presentation
- The 49th Annual Muscuioskeletal Tumor Meetiong of the Japanese Orthopaedic Association, Jul. 2016, Japanese, The Japanese Orthopaedic Association, 東京, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- The 89th Annual Meetin of the Japanese Orthopaedic Association, May 2016, Japanese, The Japanese Orthopaedic Association, 横浜, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療成績Poster presentation
- The 126th Meeting of the Central Japan Asscciation of Orthopaedic Surgery and Traumatology, Apr. 2016, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 浜松, Domestic conference乳幼児に股義足を作成し歩行を獲得した1例Oral presentation
- The 126th Meeting of the Central Japan Asscciation of Orthopaedic Surgery and Traumatology, Apr. 2016, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 浜松, Domestic conference乳幼児に股関節義足を作成し歩行を獲得した一例Poster presentation
- The 45th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2016, Japanese, The Japanese Society for Spine Surgery and Related Research, 千葉, Domestic conference脊椎転移に対する集学的治療の予後改善効果(シンポジウム・ワークショップパネル)[Invited]Nominated symposium
- The 45th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2016, Japanese, The Japanese Society for Spine Surgery and Related Research, 千葉, Domestic conference脊椎転移に対する集学的治療の予後改善効果Oral presentation
- Orthopaedic Research Society 62nd Annual Meeting 2016, Mar. 2016, English, Orthopaedic Research Society, Orland, USA, International conferenceCombination therapy of Smac mimetic and doxorubicin on osteosarcoma cellsPoster presentation
- Orthopaedic Research Society 62nd Annual Meeting 2016, Mar. 2016, English, Orthopaedic Research Society, Orland, USA, International conferenceAICAR induces Apoptosis in Human Osteosarcoma Cells through AMPK-dependent PGC-1α/TFAM/Mitochondrial PathwayPoster presentation
- 第143回関西骨軟部腫瘍研究会(臨床), Feb. 2016, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference前腕軟部腫瘍Oral presentation
- The 26th Annual Meeting of the Japanese Pediatric Orthopaedic Association, Dec. 2015, English, The Japanese Pediatric Orthopaedic Association, 岐阜, Domestic conferenceAchievement of developmental milestones by a hip disarticulation prosthesis in infancy.- a case report -Poster presentation
- 第142回関西骨軟部腫瘍研究会(臨床), Nov. 2015, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference左脛骨骨腫瘍の1例Oral presentation
- 第16回近畿骨軟部腫瘍談話会, Nov. 2015, Japanese, 近畿骨軟部腫瘍談話会, 大阪, Domestic conference骨盤骨腫瘍Oral presentation
- 2015 Annual Meeting of the Connective Tissue Oncology Society, Nov. 2015, English, Connective Tissue Oncology Society, Salt Lake City, USA, International conferenceApoptotic Effect of AICAR on Osteosarcoma Cell LinesOthers
- 第5回スペーサー治療研究会, Oct. 2015, Japanese, スペーサー治療研究会, 京都, Domestic conference骨盤周囲の悪性骨軟部腫瘍に対する粒子線治療‐整形外科の症例からの経験‐Oral presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2015, Japanese, The Japanese Orthopaedic Association, 富山, Domestic conference骨肉腫細胞に対するSMAC摸倣薬とドキソルビシンの併用効果Poster presentation
- The 125th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2015, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 名古屋, Domestic conference後骨間神経麻痺を呈した前腕脂肪腫の一例Oral presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association., Oct. 2015, Japanese, The Japanese Orthopaedic Association., 富山, Domestic conference悪性腫瘍の炭酸ガス経皮吸収の感受性の差異の検討Oral presentation
- 57th Annual Meeting of the American Society for Radiation Oncology (ASTRO), Oct. 2015, English, American Society for Radiation Oncology, San Antonio, USA, International conferenceSpinal Instability Is Associated With Local Failure After Radiation Therapy in Patients With Spinal MetastasesPoster presentation
- The 30th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2015, Japanese, The Japanese Orthopaedic Association, 富山, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Oral presentation
- 4th Annual Meeting Japan Association of Spine Surgeons with Ambition, Aug. 2015, Japanese, Japan Association of Spine Surgeons with Ambition, 福岡, Domestic conference脊椎転移に集学的治療の予後改善効果Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference軟部肉腫広範切除後皮膚欠損に対する遊離植皮における陰圧創傷閉鎖法併用の治療経験Poster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference当院における四肢転移性骨腫瘍に対する外科的治療成績Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference脊椎転移に集学的治療の予後改善効果Poster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨肉腫細胞に対するSMAC摸倣薬とドキソルビシンの併用効果Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨転移キャンサーボード(bone metastasis board:BMB)による転移性骨腫瘍のマネジメントPublic symposium
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conference骨巨細胞腫の治療成績Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association., Jul. 2015, Japanese, The Japanese Orthopaedic Association., 香川, Domestic conference悪性腫瘍に対する炭酸ガス経皮吸収の最適化投与条件の検討Oral presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conferenceSurvivin抑制薬"YM155"は骨肉腫細胞において腫瘍増殖を抑制するPoster presentation
- The 48th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2015, Japanese, The Japanese Orthopaedic Association, 香川, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- Asia Pacific Paediatric Orthopaedic Society 2015, Jun. 2015, English, Asia Pacific Paediatric Orthopaedic Society, Hong Kong, China, International conferenceEmergency hip disarticulation for a giant infantile fibrosarcoma of the lower extremity - a case report -Poster presentation
- 42nd Annual Meeting of the International Society for the Study of the Lumber Spine, Jun. 2015, English, The International Society for the Study of the Lumbar Spine, San Francisco, USA, International conferencecost-utility of surgical treatment for patients with spinal metastasisOral presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference薬物による疼痛コントロールが困難であった腎細胞癌脛骨骨転移に対しPTB式免荷装具が有効であったI症例Poster presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組み -2年目を経過して-Oral presentation
- The 52nd Annual Meeting of the Japanese Association of Rehabilitation Medicine, May 2015, Japanese, The Japanese Association of Rehabilitation Medicine, 新潟, Domestic conference脊椎転移に集学的治療の治療成績Oral presentation
- The 88th Annual Meeting of the Japanese Orthopaedic Association, May 2015, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference骨巨細胞腫の治療成績Oral presentation
- The 15th International Congress of Radiation Research, May 2015, English, 京都, International conferenceSpinal instability is associated with local recurrence after radiotherapy in patients with spinal metastasesPoster presentation
- The 124th Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2015, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 金沢, Domestic conference小児の足関節内に生じた骨軟骨形成性腫瘍の1例Oral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference骨転移専門tumor boardの取り組みOral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conference高齢者脊椎転移に対する手術成績Oral presentation
- 第74回日本医学放射線学会, Apr. 2015, English, 日本医学放射線学会, 横浜, Domestic conferencePrognostic factors for local control and survival after radiotherapy in patients with spinal metastasesOral presentation
- The 44th Annual Meeting of the Japanese Society for Spine Surgery and Related Research, Apr. 2015, Japanese, The Japanese Society for Spine Surgery and Related Research, 福岡, Domestic conferenceEuroQOL-5D(EQ-5D)を用いた転移性脊椎腫瘍に対する手術加療の費用対効用Oral presentation
- Orthopaedic Research Society 61st Annual Meeting 2015, Mar. 2015, English, Orthopaedic Research Society, Las Vegas, USA, International conferenceYM155, A Novel Small Molecule Survivin Suppressant, Reduces Tumor Progression of Human Musculoskeletal MalignanciesPoster presentation
- The Annual Meething of the European Society of Radiology, Mar. 2015, English, European Society of Radiology, Vienna, Austria, International conferenceGadolinium retention in musculoskeletal soft tissue with normal renal function; macrocyclic Gd contrast agent versus linear chelate Gd contrast agentOral presentation
- 第140 回関西骨軟部腫瘍研究会(臨床), Feb. 2015, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右橈骨腫瘍Oral presentation
- The 27th Annual Meeting of the Japanese society for Radiation Oncology, Dec. 2014, Japanese, The Japanese society for Radiation Oncology, 横浜, Domestic conference脊椎転移による脊髄損傷リスクの検討(第2報)Oral presentation
- 100th RSNA, Dec. 2014, English, Radiological Sociiety of North America, USA, Chicago, International conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of Gadolinium retention in human bone tissue with normal renal function. Interim Report.Oral presentation
- 100th Radiological Society of North America, Nov. 2014, English, Radiological Society of North America, Chicago, USA, International conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of Gadolinium Retention in Human Bone Tissue with Normal Renal FunctionOral presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceReoxygenation by transcutaneous CO2 therapy decreases expressions of iPS cell-related genes in a human MFH cell linePoster presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceYM155,a Novel Small-Molecule Survivin Suppressant, Reduces Progression of human Malignant Fibrous HistiocitomaH cellsPoster presentation
- The 123rd Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Oct. 2014, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 名古屋, Domestic conference緊急的に股関節離断術を施行した乳児型線維肉腫の一例Oral presentation
- The 18th Biennial Congress of Asia Pacific Orthopaedic Association, Oct. 2014, English, Asia Pacific Ortopaedic Asociation, Pattaya, Thailand, International conferenceYM155, A Novel Small-Molecule Survivin Suppressant, Suppresses Tumor Progression With Increased Mitochondrial Apoptosis In Human Malignant Fibrous Histiocitoma.Poster presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceMRI造影剤投与後の骨中ガドリニウム濃度についてPoster presentation
- The 29th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2014, Japanese, The Japanese Orthopaedic Association, 鹿児島, Domestic conferenceAICARの骨肉腫細胞に対するアポトーシス誘導効果Poster presentation
- The 15th Asian Oceanian Congress of Radiology, Sep. 2014, English, Asian Oceanian Congress of Radiology, 神戸, International conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesPoster presentation
- The 47th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2014, Japanese, The Japanese Orthopaedic Association, 大阪, Domestic conference新生児の下肢に発症した乳児線維肉腫の一例Poster presentation
- The 47th Annual Musculoskeletal Tumor Meeting of the Japanese Orthopaedic Association, Jul. 2014, Japanese, The Japanese Orthopaedic Association, 大阪, Domestic conferenceYM155, a Novel Small-Molecule Survivin Suppressant, Reduces Progression of Human Malignant Fibrous Histiocitoma Cells.Oral presentation
- 51st Annual Meeting of The Japanese Association Rehabilitation Medicine, Jun. 2014, Japanese, TheJapanese Association of Rehabilitation Medicine, 名古屋, Domestic conference当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組みOral presentation
- 51st Annual Meeting of The Japanese Association Rehabilitation Medicine, Jun. 2014, Japanese, TheJapanese Association of Rehabilitation Medicine, 名古屋, Domestic conference転移性脊椎腫瘍に対する手術成績-手術、非手術例の全身状態、日常生活動作に関する前向き研究-Oral presentation
- 第51回日本リハビリテーション医学会学術集会, Jun. 2014, Japanese, 日本リハビリテーション医学会, 名古屋, Domestic conference著明な骨融解像を伴う骨盤骨転移患者に発症から緩和期までリハビリテーション介入を行った1例Poster presentation
- 51st Annual Meetihg of The Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conferenceTranscutaneous CO2 Therapy Suppresses Tumor Growth and iPS-Related Gene Expressions in SarcomaOral presentation
- 51st Annual Meetihg of The Japanese Association of Rehabilitation Medicine, Jun. 2014, Japanese, The Japanese Association of Rehabilitation Medicine, 名古屋, Domestic conference大腿切断5年後に発症した断端神経腫の一例Poster presentation
- 第87回日本整形外科学会学術総会, May 2014, Japanese, 日本整形外科学会, 神戸, Domestic conference転移性脊椎腫瘍への最新の知見 転移性脊椎腫瘍に対する手術成績 手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究[Invited]Poster presentation
- The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference転移性脊椎腫瘍に対する手術成績 -手術、非手術例の生命予後、全身状態、日常生活動作に関する前向き研究-[Invited]Nominated symposium
- 第87回日本整形外科学会総会学術集会, May 2014, Japanese, 日本整形外科学会, 神戸, Domestic conference炭酸ガス経皮投与は乳癌骨転移による骨破壊を抑制するOral presentation
- 第87回日本整形外科学会総会学術集会, May 2014, Japanese, 日本整形外科学会, 神戸, Domestic conference炭酸ガス経皮投与は骨・軟部肉腫におけるiPS関連遺伝子の発現を低下させるOral presentation
- The 87th Annual Meeting of the Japanese Orthopaedic Association, May 2014, Japanese, The Japanese Orthopaedic Association, 神戸, Domestic conference骨・軟部腫瘍 希少疾患に光明をもたらす夢の実現へ -悪性骨・軟部腫瘍に対する炭酸ガス経皮投与療法-[Invited]Nominated symposium
- 第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference転移性脊椎腫瘍患者の手術、非手術例における生命予後、歩行状態に関する前向き研究Oral presentation
- The 122nd Meeting of the Central Japan Association of Orthopaedic Surgery and Traumatology, Apr. 2014, Japanese, The Central Japan Association of Orthopaedic Surgery and Traumatology, 岡山, Domestic conference炭酸ガスと放射線併用療法による骨軟部肉腫に対する新しい治療法戦略の確立Oral presentation
- The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- 第43回日本脊椎脊髄病学会学術集会, Apr. 2014, Japanese, 日本脊椎脊髄病学会, 神戸, Domestic conference高悪性度転移性脊椎腫瘍患者の手術例における全身状態、日常生活動作に関する前向き研究Oral presentation
- 第73回日本医学放射線学会, Apr. 2014, Japanese, 日本医学放射線学会, 横浜, Domestic conferenceRetrospective analysis of risk factors influencing survival and gait disturbance in patients with spinal metastasesOral presentation
- The 73rd Annual Meeting of the Japan Radiological Sociey, Apr. 2014, Japanese, The Japan Radiological Sociey, 横浜, Domestic conferenceComparison of Gd-DTPA-BMA versus Gd-DOTA of gadolinium retention in human bone tissue work-in-progressOral presentation
- 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conferenceYM155, A Novel Small Molecule Survivin Suppressant, Reduces Tumor Progression of Human Malignant Fibrous Histiocytoma.Poster presentation
- 60th Annual Meeting of Orthopaedic Research Society, Mar. 2014, English, Orthopaedic Research Society, New Orleans, USA, International conferenceTranscutaneous Carbon Dioxide (CO2) Therapy Suppresses Bone Destruction By Breast Cancer Metastasis With Decreased Expression Of Hypoxia-inducible Factor-1α (Hif-1α) In Vivo.Oral presentation
- 第55回日本小児血液・がん学会学術集会, Nov. 2013, Japanese, 日本小児血液・がん学会, 福岡, Domestic conference初診時に血管腫と鑑別を要した右下腿原発乳児線維肉腫の新生児例Poster presentation
- 日本放射線腫瘍学会第26回学術大会, Oct. 2013, Japanese, 日本放射線腫瘍学会, 青森(ホテル青森、リンクステーションホール青森), Domestic conference脊椎転移による脊椎損傷リスクの検討Poster presentation
- The 28th annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2013, Japanese, The Japanese Orthopaedic Association, 千葉, Domestic conferenceヒト悪性線維性組織球腫株におけるSurvivin抑制によるアポトーシスの検討Oral presentation
- 8th Combined Meeting of Orthopaedic Research Societies, Oct. 2013, English, Orthopaedic Research Society, Venice, Italy, International conferenceThe effects of reoxygenation using a novel CO2 therapy on radiosensitivity in human malignant fibrous histiocytoma cells.Oral presentation
- 8th Combined Meeting of Orthopaedic Research Societies, Oct. 2013, English, Orthopaedic Research Society, Venice, Italy, International conferenceSurvivin inhibition induces mitochondrial apoptosis in human MFH cells.Oral presentation
- APOA 2013, Aug. 2013, Japanese, Asia Pacific Orthopaedic Association, Kuching, Malaysia, International conferenceBacterial knee arthritis caused by Brodie's abscess in the distal femoral epiphysis.Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference乳癌細胞株を移植した動物モデルに対する経皮的炭酸ガス治療の効果Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference大腿切断後の断端shrinkageに対し従来の吸着式ソケットにより良好な成績を得た1例Oral presentation
- The 50th Annual Meeting of Yhe Japanese Association of Rehabilitation Medicine, Jun. 2013, Japanese, The Japanese Association of Rehabilitation Medicine, 東京, Domestic conference骨肉腫肺転移マウスモデルに対する経皮炭酸ガス療法の効果の検討Oral presentation
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference炭酸ガス経皮投与は骨肉腫細胞の腫瘍増大と転移能を抑制するOral presentation
- The 86th Annual Meeting of the Japanese Orthopaedic Association, May 2013, Japanese, The Japanese Orthopaedic Association, 広島, Domestic conference高純度β-リン酸三カルシウム(β-TCP)を骨補填材料として使用した良性骨腫瘍の治療成績Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceTranscutaneous Application of CO2 Induced Mitochondrial Apoptosis in Human Malignant Tumors.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceThe Effects of Reoxygenation Using a Novel CO2 Therapy on Metastatic Potentials in Osteosarcoma.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceRegulation of Mitochondrial Number Induces Apoptosis in Musculoskeletal Malignancies.Oral presentation
- 59th Annual Meeting of the Orthopaedic Research Society, Jan. 2013, English, Orthopaedic Research Society, San Antonio, International conferenceDecoy Receptor 3 Regulates Migration and Invasion Abilities via Promoting MMP-2 Expression through PI3K/Akt Pathway in Human Malignant Fibrous Histiocytoma.Oral presentation
- 第23回 日本小児整形外科学会学術集会, Nov. 2012, Japanese, 日本小児整形外科学会, 福岡, Domestic conference化膿性膝関節炎をきたした骨端部Brodie膿瘍の1例Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conference炭酸ガス経皮投与療法を用いた骨・軟部肉腫に対する新しい治療法Oral presentation
- 第27回日本整形外科学会基礎学術集会, Oct. 2012, Japanese, 日本整形外科学会, 名古屋, 炭酸ガス経皮吸収により骨肉腫肺転移は有意に抑制され、その効果はMMP発現の抑制によるものと推察された, Domestic conference炭酸ガス経皮投与はMMP群の発現を抑制することで骨肉腫細胞の肺転移能を低下させるOral presentation
- 第119回中部日本整形外科災害外科学会・学術集会, Oct. 2012, Japanese, 中部日本整形外科災害外科学会, 福井, Domestic conference血管柄付腓骨移植を用いて再建した足根骨骨巨細胞腫の1例Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conferenceミトコンドリア量調節による悪性骨・軟部腫瘍に対する治療の可能性Oral presentation
- The 27th Annual Research Meeting of the Japanese Orthopaedic Association, Oct. 2012, Japanese, The Japanese Orthopaedic Association, 名古屋, Domestic conferenceヒトMFH細胞におけるDcR3の増殖能・遊走能・浸潤能に対する影響の検討Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceTranscutaneous Application of CO2 Induced Mitochondrial Apoptosis in Human Malignant Tumors.Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceRegulation of Mitochondrial Number Induces Cellular Apoptosis in Human Sarcomas.Oral presentation
- 9TH ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY MEETING, Sep. 2012, English, ASIA PACIFIC MUSCULOSKELETAL TUMOUR SOCIETY, Kuala Lumpur, International conferenceDecoy Receptor 3 Enhances Migration and Invasion Ability by Regulating MMP-2 and MMP-9 expression in human MFH cells.Oral presentation
- 第45回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2012, Japanese, The Japanese Orthopedic Association, 東京, Domestic conference腓骨骨腫瘍の一例Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference低酸素環境の改善はヒトMFH細胞においてミトコンドリア量を増加させるOral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference炭酸ガス経皮投与療法を用いたヒトMFHに対する新しい治療法Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference体幹部に発生した悪性軟部腫瘍に対する治療成績Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conference脂肪肉腫の治療成績Oral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2012, Japanese, 日本整形外科学会, 東京, Domestic conferenceDcR3はMMP発現を介してヒトMFH細胞の遊走能および浸潤能を抑制するOral presentation
- The 85th Annual Meeting of the Japanese Orthopaedic Assosiation, May 2012, Japanese, The Japanese Orthopaedic Association, 京都, Domestic conferenceDcR3発現抑制はMFH細胞において細胞遊走能および浸潤能を抑制し、FasLによるアポトーシスを亢進させるOral presentation
- 第45回日本整形外科学会 骨・軟部腫瘍学術集会, Apr. 2012, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference腓骨骨腫瘍の1例[Invited]Invited oral presentation
- 第118回中部日本整形外科災害外科学会, Apr. 2012, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference胸壁悪性軟部腫瘍に対する治療成績Oral presentation
- 58st Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceTranscutaneous application of CO2 induced mitochondrial apoptosis in human malignant fibrous histiocytoma.Oral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceTranscutaneous application of CO2 enhanced radiosensitivity in human malignant histiocytoma cells in vivoOral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceSilencing of decoy receptor 3 enhances FasL induced apoptosis and decreases migration and invasion ability in human MFH cells.2Oral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceProtein kinase D1 negatively regulates invasion and migration ability of human osteosarcoma cellsOral presentation
- 58th Annual Meeting of the Orthopaedic Research Society, Jan. 2012, English, Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceMitochondrial proliferation induces apoptosis of human malignant fibrous histiocytomaOral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果Oral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferenceヒト悪性線維性組織球腫細胞株におけるDecoy receptor 3の抗アポトーシス作用およびFas ligandによるアポトーシス誘導に関する検討Oral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceRegeneration of mitochondrial proliferation by PGc-1a induces apoptosis in human MHF cellsOral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferenceProtein Kinase C-deltaのヒトMFH細胞に対するアポトーシスへの影響についての検討Oral presentation
- 第26回 日本整形外科学会基礎学術集会, Oct. 2011, Japanese, 日本整形外科学会, 前橋, Domestic conferencePGC-1α過剰発現によるミトコンドリアの増殖はMFHにおいてアポトーシスを促進するOral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceDecoy receptor 3 inhibits apoptosis and promotes cell migration in human malignant fibrous histiocytoma cellsOral presentation
- 16th 2011Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, Oct. 2011, English, Combined Meeting of Connective Tissue Oncology Society and the Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceClinical outcome of additional wide excision for patients with malignant soft tissue tumorsOral presentation
- 第30回日本運動器移植・再生医学研究会, Sep. 2011, Japanese, 日本運動器移植・再生医学研究会, 福岡, Domestic conference良性骨腫瘍切除後骨欠損に対する高純度β-リン酸三カルシウム(β-TCP)充填の治療成績Oral presentation
- 第436回整形外科集談会京阪神地方会, Sep. 2011, Japanese, 整形外科集談会京阪神地方会, 大阪, Domestic conference大腿切断後に断端神経腫を発症した1例Oral presentation
- The 2011 European Multidisciplinary Cancer Congress, Sep. 2011, English, Europe Canser organization, ストックホルム, スウェーデン, International conferenceMitochondrial proliferation induces apoptosis in human MFH cells by PGC-1 alpha overexpressionOral presentation
- The 2011 European Multidisciplinary Cancer Congress, Sep. 2011, English, Europe Canser organization, ストックホルム, スウェーデン, International conferenceAnti-apoptotic effect of decoy receptor 3 in human malignant fibrous histiocytoma cellsOral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference術後に局所再発を来した軟部肉腫の検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference悪性軟部腫瘍に対する追加広範囲切除の治療成績Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤ベバシズマブの効果Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceヒト悪性線維性組織球腫細胞株におけるdecoy receptor 3の抗アポトーシス作用に関する検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceヒトMFH細胞株におけるprotein kinase C-deltaのアポトーシスへの影響についての検討Oral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceProtein kinase D1は骨肉腫細胞においてMMP-2およびMMP-9の発現を制御して抗腫瘍効果を示すOral presentation
- 第44回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2011, Japanese, 日本整形外科学会, 京都, Domestic conferenceMFHに対するsurvivinを標的とした分子標的治療の可能性Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conference分化型脂肪肉腫の治療成績Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の発現についての検討Oral presentation
- 第46回日本理学療法学術大会, May 2011, Japanese, 日本理学療法学術会, 宮崎, Domestic conference悪性骨腫瘍に伴う大腿骨病的骨折に対して創外固定術後に腫瘍用人工膝関節置換術を施行した就学児童の一症例 自立歩行獲得までの経緯Oral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会学, 横浜, Domestic conferenceSurvivinはMFHに対する治療の標的になりうるOral presentation
- 第84回日本整形外科学会学術総会, May 2011, Japanese, 日本整形外科学会, 横浜, Domestic conferenceSIRT1阻害による骨・軟部肉腫に対する細胞増殖抑制効果Oral presentation
- 第116回中部日本整形外科災害外科学会, Apr. 2011, Japanese, 中部日本整形外科災害外科学会, 高知, Domestic conference幼児の大腿骨骨端部骨髄炎の一例 X線、MR所見の経時的変化Oral presentation
- 第127回関西骨軟部腫瘍研究会, Nov. 2010, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference右前腕軟部腫瘍Oral presentation
- CTOS 16th Annual Meeting, Nov. 2010, English, Connective Tissue Oncology Society, パリ, フランス, International conferenceThe Effect of Bevacizumab (Avastin) in Combination with Doxorubicin on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal Model.Poster presentation
- CTOS 16th Annual Meeting, Nov. 2010, English, Connective Tissue Oncology Society, パリ, フランス, International conferenceClinical outcome of patients with malignant fibrous histiocytoma in the soft tissueOral presentation
- 第115回中部日本整形外科災害外科学会, Oct. 2010, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference脛骨神経に発生したintraneural hemangiomaの1例Oral presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の作用についての検討Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conference骨・軟部悪性腫瘍におけるSIRT1の発想とその阻害による抗腫瘍効果Poster presentation
- 第25回日本整形外科学会 基礎学術集会, Oct. 2010, Japanese, 日本整形外科学会, 京都, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤ベバシズマブとドキソルビシンの併用療法の効果についてPoster presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference腹壁外デスモイドの治療成績Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference骨・軟部腫瘍におけるprotein kinase D1の発現についての検討Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference骨・軟部腫瘍におけるprotein kinase C-deltaの細胞増殖に関する役割についての検討Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性線維性組織球腫細胞株に対する血管新生阻害剤bevacizumabの効果Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性線維性組織球腫の治療成績Oral presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conference悪性腫瘍と鑑別を要した肩甲背部に発生した骨化性筋炎の1例Poster presentation
- 第43回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2010, Japanese, 日本整形外科学会, 東京, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルに対する血管新生阻害剤bevacizumabとdoxorubicinの併用療法の効果についてOral presentation
- 第430回整形外科集談会京阪神地方会, Jun. 2010, Japanese, 中部日本整形外科災害外科学会, 大阪, Domestic conference下垂足で発症した神経内ガングリオンの1例Oral presentation
- 21st Meeting of the European Association for Cancer Research, Jun. 2010, English, European Association for Cancer Research, オスロ, ノルウェー, International conferenceThe Effect of Bevacizumab on Intratumoral Angiogenesis of Malignant Fibrous Histiocytoma in Animal Model.Poster presentation
- 21st Meeting of the European Association for Cancer Research, Jun. 2010, English, European Association for Cancer Research, オスロ, ノルウェー, International conferenceRole of Protein Kinase C δ in Musculoskeletal Tumors.Poster presentation
- 第125回関西骨軟部腫瘍研究会, May 2010, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference脛骨骨腫瘍の1例Oral presentation
- 第114回中部日本整形外科災害外科学会, Apr. 2010, Japanese, 中部日本整形外科災害外科学会, 名古屋, Domestic conference化膿性関節炎をきたした骨端部Brodie膿瘍の2例Poster presentation
- 56th Annual Meeting of the Orthopaedic Research Society, Mar. 2010, English, The Orthopaedic Research Society, ニューオリンズ, アメリカ, International conferenceThe Effect of Bevacizumab on Intratumoral Angiogenesis of Malignant Fibrous Histiocytoma in Animal ModelOral presentation
- 56th Annual Meeting of the Orthopaedic Research Society, Mar. 2010, English, The Orthopaedic Research Society, ニューオリンズ, アメリカ, International conferenceROLE OF PROTEIN KINASE C d IN MUSCULOSKELETAL TUMORSOral presentation
- 第122回関西骨軟部腫瘍研究会, Nov. 2009, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference後頚部軟部腫瘍Oral presentation
- 第123回関西骨軟部腫瘍研究会, Nov. 2009, Japanese, 関西骨軟部腫瘍研究会, 大阪, Domestic conference肩甲背部腫瘍Oral presentation
- 第24回日本整形外科学会 基礎学術集会, Nov. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルにおける血管新生阻害剤bevacizumabの効果の検討Oral presentation
- 第24回日本整形外科学会 基礎学術集会, Nov. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceMFH細胞株に対する血管新生阻害剤bevacizumabの効果Oral presentation
- 第113回中部日本整形外科災害外科学会, Oct. 2009, Japanese, 中部日本整形外科災害外科学会, 神戸, Domestic conference高純度β-TCPを用いた良性骨腫瘍に対する術後成績Public symposium
- 兵庫県膝関節研究会, Sep. 2009, Japanese, 兵庫県膝関節研究会, 神戸, Domestic conference特発性膝関節血症の2症例Oral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceTreatment of fibrous dysplasiaOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceThe Effect of Bevacizumab (Avastin) on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal ModelOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceProtein kinase delta expression in musculoskeletal tumorsOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceOncologic and functional outcome of malignant pelvic bone tumors after carbon iron radiotherapyOral presentation
- ISOLS/MSTS combined meeting, Sep. 2009, English, International Symposium of Limb Salvage/Musculoskeletal Tumor Society, ボストン, アメリカ, International conferenceEffect of angiogenesis inhibitor PTK787 for malignant fibrous histiocytoma in vitroOral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference脱神経筋萎縮を伴った悪性末梢神経鞘腫瘍の2例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference骨盤悪性腫瘍に対する重粒子線治療後の患肢機能評価Public symposium
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference骨・軟部悪性腫瘍に対するsecond line化学療法としてのICE療法Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference激烈な坐骨神経痛を呈しPETにより検出しえた坐骨神経内結節性筋膜炎の1例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conference悪性軟部腫瘍MFHにおけるスフィンゴシンキナーゼの発現および細胞増殖への検討Oral presentation
- 第42回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2009, Japanese, 日本整形外科学会, 横浜, Domestic conferenceマウス悪性線維性組織球腫(MFH)モデルにおける血管新生阻害剤bevacizumabの効果の検討Oral presentation
- 第112回中部日本整形外科災害外科学会, Apr. 2009, Japanese, 中部日本整形外科災害外科学会, 京都, Domestic conference悪性軟部腫瘍との鑑別を要したchronic expanding hematomaの2例Oral presentation
- 第424回整形外科集談会京阪神地方会, Mar. 2009, Japanese, なし, 大阪, Domestic conference上腕骨近位骨端部に発生したランゲルハンス細胞組織球症の1例Oral presentation
- 脊椎外科を学ぶ会, Feb. 2009, Japanese, なし, 大阪, Domestic conference胸椎椎体の急速破壊をきたした腫瘍類似疾患の1例Oral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceThe Expressions of Sphingosine Kinase-1 in Human Malignant Fibrous Histiocytoma (MFH) Cell Lines, and the Role of Sphingosine Kinase-2 in Growth of MFH Cell LinesOral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceThe Effect of Bevacizumab (Avastin) on Tumor Growth of Malignant Fibrous Histiocytoma in the Animal Model.Oral presentation
- 第91回神戸甲状腺研究会, Feb. 2009, Japanese, なし, 神戸, Domestic conferenceMetastasizing thyroid noduleの2例Oral presentation
- 55th Annual Meeting of the Orthopaedic Research Society, Feb. 2009, English, The Orthopaedic Research Society, ラスベガス, アメリカ, International conferenceEffect of siRNA for DcR4 on Apoptosis in Osteosarcoma cells.Oral presentation
- 第23回日本整形外科学会 基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference血管新生抑制剤 bevacizumabの悪性線維性組織球腫(MFH)に対するin vivoでの効果Oral presentation
- 第23回日本整形外科学会 基礎学術集会, Oct. 2008, Japanese, 日本整形外科学会, 京都, Domestic conference悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討Oral presentation
- 第111回中部日本整形外科災害外科学会, Oct. 2008, Japanese, 中部日本整形外科災害外科学会, 金沢, Domestic conferenceBenign lipoblastomaの2例Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference若年者骨・軟部悪性腫瘍に対する末梢血幹細胞移植を併用した超大量化学療法Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference骨盤悪性腫瘍に対する重粒子線治療の治療成績Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference骨・軟部腫瘍株におけるsiRNAを用いたDcR3抑制効果Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conference悪性骨・軟部腫瘍におけるEDGレセプターおよびスフィンゴシンキナーゼの発現の検討Oral presentation
- 第41回日本整形外科学会 骨・軟部腫瘍学術集会, Jul. 2008, Japanese, 日本整形外科学会, 浜松, Domestic conferenceガドリニウム中性子捕捉療法を目指したMRIによる腫瘍細胞株へのMRI造影剤の付着取り込みの評価Oral presentation
- 兵庫県マイクロサージェリー研究会, May 2008, Japanese, 兵庫県マイクロサージェリー研究会, 神戸, Domestic conference橈骨骨肉腫に対して血管柄付き腓骨移植術を利用した治療Oral presentation
- 第81回日本整形外科学会学術集会, May 2008, Japanese, 日本整形外科学会, 札幌, Domestic conference悪性骨・軟部腫瘍の脂質代謝経路におけるEDGレセプターおよびスフィンゴシンキナーゼの検討Oral presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceThe Expressions of EDG Receptors and Sphigosine Kinases in Malignant Bone and Soft Tissue Tumors.Poster presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceMRI Contrast Agents in Malignant Fibrous Histiocytoma (MFH) for Gadolinium Neutron Capture Therapy (Gd-NCT).Poster presentation
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, Mar. 2008, English, The Orthopaedic Research Society, サンフランシスコ, アメリカ, International conferenceEffect of angiogenesis inhibitor PTK787 for MFH in vitro.Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conference骨・軟部腫瘍におけるDcR3の検討Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conferenceMRIを用いたMRI造影剤の腫瘍細胞株における付着・取り込み特性の評価-ガドリニウム中性子捕捉療法を目指して-Poster presentation
- 第22回日本整形外科学会基礎学術集会, Oct. 2007, Japanese, 日本整形外科学会, 浜松, Domestic conferenceMFH細胞株に対する血管新生阻害剤PTK787の効果Oral presentation
- 14thInternationalsymposiumonlimbsalvage, Sep. 2007, English, International symposium on limb salvage, ハンブルグ, ドイツ, International conferenceVEGF and angiogenesis in bone and soft tissue tumors.Oral presentation
- 14thInternationalsymposiumonlimbsalvage, Sep. 2007, English, International symposium on limb salvage, ハンブルグ, ドイツ, International conferenceTreatment for giant cell tumorOral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference線維性骨異形成の治療成績Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference骨盤腫瘍の1例Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conference骨・軟部腫瘍におけるDcR3の検討Oral presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conferenceヒト骨・軟部肉腫細胞株に対するRaf-1 Kinase Inhibitorによる抗腫瘍効果の検討Poster presentation
- 第40回日本整形外科学会骨・軟部腫瘍学術集会, Jul. 2007, Japanese, 日本整形外科学会, 甲府, Domestic conferenceIn vitroでのMFHに対する血管新生阻害剤PTK787の効果Poster presentation
■ Research Themes
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2024 - 31 Mar. 2027Effects of an antioxidant flavonoid on muscle atrophy associated with cachexia in pediatric osteosarcoma
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025粘液線維肉腫に対するホウ素中性子捕捉療法(BNCT)を用いた新たな治療方法の開発原発性の粘液線維肉腫に対する治療の原則は手術による全切除である。しかし、体幹部などの手術困難な部位での腫瘍の発生例、あるいは、粘液線維肉腫は高齢者の四肢に好発する腫瘍であるため、侵襲的な手術による術後の活動度の低下などにより、特に高齢の罹患者では治療に難渋する場合が多い。ここで、近年、腫瘍細胞内に選択的にホウ素製剤(BPA)を取り込まさせ、熱中性子線照射による中性子とホウ素との核分裂反応により腫瘍細胞のみを選択的に死滅させるホウ素中性子捕捉療法(BNCT)が着目されている。そこで、本研究では、粘液線維肉腫に対するBNCTを用いたより侵襲の少ない治療方法の可能性について検討を行った。令和5年度は、令和4年度に施行した粘液線維肉腫に対するホウ素中性子捕捉療法(BNCT)の効果を解析し、その結果を学会等で報告・検討した。本研究では、上肢発生の粘液線維肉腫に罹患した患者から新たに樹立した腫瘍細胞株からヌードマウスを用いた担がん動物モデルを作成した。同担がん動物モデルを用いてBNCTを施行したところ、ホウ素製剤BPA投与後のホウ素の体内動態の解析からは腫瘍細胞へのホウ素の集積はやや低値であるにも関わらず、BNCTによる抗腫瘍効果を認めた。そこで、組織検査にて検討を行うと、粘液を産生する腫瘍細胞のため、単位体積あたりのホウ素の取り込みが見かけ上少なくなることが要因と考えられた。これは、粘液線維肉腫に対してBNCT施行を検討する際に、BPA取り込みが過小評価されBNCT適応が無いと判断される可能性があることを示唆する。さらに、粘液線維肉腫のみならず腫瘍細胞密度が低い腫瘍に対するBNCTの検討時には、適応について十分な注意を要することを意味する。これらの検討結果は学会にて報告し同意を得た。そして、粘液線維肉腫は、BNCTによる抗腫瘍効果が期待できる肉腫の一つである可能性についても確認した。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025サルコペニアの骨格筋に対する経皮的炭酸ガス投与法の効果についてサルコペニアの成因や病態については明らかにされていない部分も多く、基礎研究が進行中であるが、臨床的には診断ガイドラインも作成されており、予防や治療法の確立が望まる。現在のところ、有効な治療法としてエビデンスが示されているのは運動療法だけであり、薬物治療や栄養療法についてのエビデンスは不十分である。サルコペニアはロコモティブシンドローム、フレイルと並んで高齢者の運動機能、身体機能の低下として問題となるが、高齢者では、運動器の慢性変性疾患による疼痛やしびれなどの自覚症状を有することが多く、さらに基礎疾患による運動制限や認知機能や気力の低下もあるため、運動療法を習慣化させることが困難である。経皮的炭酸ガス療法は運動能力が低下した状態においても施術が可能で低侵襲な新規治療法として、我々は既に骨折や悪性軟部腫瘍に対する臨床研究を行っている。有酸素運動と同様の効果が得られる本治療法が、サルコペニアに対して有効であることが示されれば、臨床応用ができ、高齢社会において大きく貢献することが可能であると考える。 そのためにはまず、自然発症高血圧ラット(SHR)に高脂肪高炭水化物食を負荷したモデル(サルコペニアラット)を使用し、経皮的炭酸ガス療法を行う。経皮的炭酸ガス治療群とコントロール群で体組成の評価を行い、摘出した骨格筋組織で病理組織学的、分子生物学的に筋量や筋サテライト細胞数の評価、筋タンパクの合成と分解に関連する因子についての評価を行う予定である。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 09 Jul. 2021 - 31 Mar. 2024Basic research about fluid-fluid phase separation and membraneless organelles in sarcoma2021年度(令和3年度)においては、既に細胞株として市販されている細胞株および当研究室で樹立した細胞株(骨肉腫:KHOS, KTHOS, MG63, SaOS2, LM8 軟部肉腫細胞株:TNMY-1, Nara-H, Nara-F, GBS-1 ユーイング肉腫細胞株:SK-ES-1, RD-ES)を細胞を継代培養し、実験に供するための準備を行った。これらの細胞株をsubconfluentな状態で細胞を回収し、先行研究で報告されているストレス顆粒関連蛋白であるTIA-1 (T-cell-restricted intracellular antigen-1), TIAR (TIA-1-related protein), G3BP1 (RAS GTPase-activating protein-binding protein 1), G3BP2 (RAS GTPase-activating protein-binding protein 2) , CAPRIN-1 (Cell Cycle associated protein 1) , USP10 (Ubiquitin carboxyl-terminal hydrolase 10)の遺伝子発現を定性的および定量的に評価するため、mRNAの抽出とcDNAライブラリーの作成を行った。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024Development of new treatment strategies for osteosarcoma using induced osteosarcoma stem cellsThe purpose of this study was to explore the new therapeutic targets in osteosarcoma using MG-OKS, an engineered osteosarcoma stem cells, that we have successfully generated in a previous study. We focused on SPRR1A, which was significantly upregulated in the engineered osteosarcoma stem cells MG-OKS compared to the parental cell line MG-63. We investigated the roles of SPRR1A in osteosarcoma by inhibition of SPRR1A expression in MG-OKS using selective siRNA. In vitro, we found that alternation in cell morphology, and decreased cell proliferation and migration abilities in SPRR1A inhibited MG-OKS, and in vivo, a decrease in tumorigenicity and Ki-67 expression was observed. Comprehensive genetic analysis showed that the expression of genes related to cell adhesion and the cell cycle was altered. These results suggest that SPRR1A may be a new therapeutic target for osteosarcoma.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2024Development of New Treatment Method for Epithelioid Sarcoma by BNCTEpithelioid sarcoma (ES) is an extremely rare sarcoma that predominates in young adults. Because it is not sensitive to anticancer drugs and radiation therapy, wide surgical excision is the basis of treatment. Therefore, in this study, BNCT was performed with the use of human ES (VA-ES-BJ cell line)-bearing nude mice, and its antitumor effect was examined. After the tumor transplanted into the thigh grew, animals were divided into 3 groups of A, B, and C. In group C (BNCT), after intravenous administration of BPA, and in group B without administration of BPA, only the tumor of both groups was irradiated with epithermal neutrons. The tumor tissue was removed and histological examination was performed 14 days after irradiation. Histological examination revealed destroyed tumor cells only in group C. For the first time, it was clear that ES regressed with only one irradiation by BNCT in this study. Therefore, a new treatment method for ES by BNCT is expected to be developed in future.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2018 - 31 Mar. 2021This study aimed to generate the cancer stem cell (CSC)-like cells from human osteosarcoma cells by introducing reprogramming factors, and to reveal the obtained cell characteristics. We could obtain the osteosarcoma stem cells by transduction of OCT3/4-KLF4-SOX2 genes into a human osteosarcoma cell line MG63. mRNA expression of reported CSC markers significantly increased in the cells. In the cells, WST-8 assays revealed that significantly lower cell proliferation and higher chemo-resistance were observed. After osteogenic induction, strongly positive staining of Alizarin red S and ALP was also observed. In vivo experiments, tumors from the cells were significantly larger in size, and strong immunopositivity of Ki-67, Osteocalcin and HIF1-α was observed. We could generate the osteosarcoma stem cells by introducing reprogramming factors. This method could be useful to elucidate the molecular mechanisms and the effective therapeutic targets in human osteosarcoma.Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2021, Principal investigatorBone metastatic model of human breast cancer was created, bone morphological and qualitative evaluation of the bone metastasis was performed in the transcutaneous carbon dioxide treatment group and the control group. The excised tissue was evaluated the hypoxic environment and the bone resorption by osteoclasts histopathologically and molecularly biologically. In the transcutaneous carbon dioxide treatment group, tumor growth was suppressed in tumor size and micro CT images. Histopathologically, the expression of HIF-1α was suppressed in the tibial lesion of the treatment group, and the number of TRAP-positive cells decreased. In addition, the expression of RANKL, IL-1β, IL-6, and IL-8 was suppressed. It is speculated that transcutaneous carbon dioxide treatment improved the hypoxic environment of breast cancer bone metastasis, suppressed the induction of osteoclast differentiation, and suppressed bone destruction.Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 30 Jun. 2017 - 31 Mar. 2020Development of new therapy for joint contractures using percutaneous carbon dioxide application.Joint contractures are a major complication following injuries in central nervous system or joint immobilization. However, no effective treatment has been developed so far. In the present study, we aimed to develop a novel therapeutic approach for joint contractures using transcutaneous carbon dioxide absorption. Our findings indicate that transcutaneous carbon dioxide may improve knee range of motion after injuries central nervous system or joint immobilization. We also revealed that transcutaneous carbon dioxide decreases muscular and articular fibrosis, thereby improving knee joint contracture.
- 学術研究助成基金助成金/挑戦的研究(萌芽), Apr. 2017 - Mar. 2020Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2014 - 31 Mar. 2019The current study have demonstrated that transcutaneous carbon dioxide application on bone, soft tissue, and metastatic tumors induces anti-tumorigenic effects and inhibits bone destruction in animal models transplanted MFH/UPS, osteosarcoma, and breast cancer cells. No adverse effects were detected and the mechanisms for anti-tumorigenic effects of transcutaneous carbon dioxide application may be an induction of apoptosis pathway through mitochondrial apoptotic function. Combination of transcutaneous carbon dioxide application and chemotherapy showed synergetic anti-tumor effect. In addition, clinical application of this therapy did not induce any adverse effects in one patient with myxofibrosarcoma. Based on the results, transcutaneous carbon dioxide application may be a new therapy for cancers.
- 科学研究費補助金/基盤研究(B), Apr. 2014 - Mar. 2018Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2014 - 31 Mar. 2017To establish a novel therapeutic strategy for bone and soft tissue sarcomas, we hypothesized that "Pluripotency" and "Mitochondrial dysfunction" would be the main cause of sarcoma progression, and evaluated antitumor effects of hypoxia improvements by the transcutaneous carbon dioxide (CO2) therapy on sarcomas. We revealed that iPS-related gene expression and mitochondrial dysfunction were associated with sarcoma progression, and that both of them were activated by hypoxic condition. In addition, transcutaneous CO2 therapy showed strong antitumor effects on sarcoma cells by decreased iPS-related gene expression and increased mitochondrial activity. The findings in this study strongly suggest that "Pluripotency" and "Mitochondrial dysfunction" should be the key of sarcoma progression, and that transcutaneous CO2 therapy can be an innovative therapeutic tool for sarcomas.Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 01 Apr. 2012 - 31 Mar. 2016The purpose of the current study was to evaluate the effects of transcutaneous CO2 therapy on the antitumor efficacy of X-ray irradiation using MFH. In the in vivo study using an animal model in which MFH cells (Nara-H) were transplanted, tumor volume in the combination group (transcutaneous CO2+X-ray) was reduced to 28%, 42% and 47% of that in the control, CO2 alone, and X-ray alone groups respectively. Apoptotic activity and ROS production in the combination group were strongly increased with decreasing HIF-1α expression relative to the control, CO2and X-ray groups. The transcutaneous CO2 system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radioresistance in human malignancies.
- 科学研究費補助金/萌芽研究, Apr. 2012 - Mar. 2015Competitive research funding
- 2004 - 2008運動器系腫瘍Competitive research funding
