Research activity information

• Jul. 2006 兵庫県産科婦人科学会, 兵庫県産科婦人科学会学術奨励賞, Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population.

  DEGUCHI MASASHI

• Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study

  Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Masashi Deguchi, Takeshi Nagamatsu, Tomoyuki Fujii, Mikiya Nakatsuka, Gen Kobashi, Hisashi Arase, Hideto Yamada

  2024, Frontiers in Immunology, 15

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study.

  Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Masashi Deguchi, Takeshi Nagamatsu, Tomoyuki Fujii, Mikiya Nakatsuka, Gen Kobashi, Hisashi Arase, Hideto Yamada

  INTRODUCTION: Anti-β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA)-DR antibodies may be a risk factor for recurrent pregnancy loss (RPL). The therapeutic modality for women with RPL and anti-β2GPI/HLA-DR antibody positivity has not been evaluated. This prospective, multicenter, observational study aimed to assess whether low-dose aspirin (LDA) and/or heparin therapies improve pregnancy outcomes in women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies. METHODS: Between August 2019 and December 2021, 462 women with RPL underwent anti-β2GPI/HLA-DR antibody measurements and risk assessments for RPL. Each attending physician decided the treatment modality for women with RPL who tested positive for anti-β2GPI/HLA-DR antibodies, and their pregnancy outcomes were followed up until December 2023. Finally, 47 pregnancies in 47 women with RPL and anti-β2GPI/HLA-DR antibody positivity were included in the analysis and were divided into two groups regarding whether they were treated with LDA and/or unfractionated heparin (UFH) (LDA/UFH group, n = 39) or with neither of them (non-LDA/non-UFH group, n = 8). The rates of live birth and pregnancy complications (i.e., preeclampsia and preterm delivery before 34 gestational weeks due to placental insufficiency) were compared between the two groups. RESULTS: The live birth rate in the LDA/UFH group was higher than that in the non-LDA/non-UFH group (87.2% vs 50.0%, p = 0.03). The pregnancy complication rate in the LDA/UFH group was significantly lower than that in the non-LDA/non-UFH group (5.9% vs 50.0%, p = 0.048). Among 21 women who tested positive for anti-β2GPI/HLA-DR antibodies and had no other risk factors for RPL, the live birth rate in the LDA/UFH group (n = 14) was much higher than that in the non-LDA/non-UFH group (n = 7) (92.9% vs 42.9%, p = 0.03). DISCUSSION: This study, for the first time, demonstrated that LDA and/or UFH therapies are effective in improving pregnancy outcomes in women with RPL and aβ2GPI/HLA-DR antibody positivity.

  2024, Frontiers in immunology, 15, 1445852 - 1445852, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Increased IL-10-competent regulatory B cells in the decidua of early human pregnancy

  Shigeki Shimada, Hiroki Sakamoto, Norifumi Iijima, Atsushi Fukui, Yutoku Shi, Masashi Deguchi, Hideto Yamada

  Elsevier BV, Dec. 2023, Journal of Reproductive Immunology, 160, 104142 - 104142

  Scientific journal


• High doses of intravenous immunoglobulin stimulate regulatory T cell and suppress natural killer cell in women with recurrent pregnancy loss.

  Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita, Mari Mitsui, Tsuyoshi Saito, Takeshi Nagamatsu, Koichi Takakuwa, Mikiya Nakatsuka, Satoshi Yoneda, Katsuko Egashira, Masahito Tachibana, Keiichi Matsubara, Ritsuo Honda, Atsushi Fukui, Kanji Tanaka, Kazuo Sengoku, Toshiaki Endo, Hiroaki Yata

  The aim was to evaluate whether natural killer (NK) cells and regulatory T (Treg) cells were involved in mechanisms underlying beneficial effects of a high dose of intravenous immunoglobulin (IVIG) on recurrent pregnancy losses (RPL) of unexplained etiology. In a double-blind, randomized, placebo-controlled trial of IVIG (400 mg/kg, for 5 days in 4-6 weeks of gestation) in women with RPL, blood samples were collected pre-infusion, one week after infusion (1 w), and eight weeks of gestation/when miscarried (8 w). Levels of NK and Treg cells in peripheral blood were compared between women with IVIG (n = 50) and placebo (n = 49), and between women with IVIG who gave live birth (n = 29) and those who had miscarriage with normal chromosome (n = 12). Effector Treg cell percentages in IVIG group at 1 w (mean 1.43 % vs. 1.03 %) and at 8 w (1.91 % vs. 1.18 %) were higher than those in placebo group (p < 0.01). Total Treg cell percentages in IVIG group at 1 w (4.75 % vs. 4.08 %) and at 8 w (5.55 % vs. 4.47 %) were higher than those in placebo group (p < 0.05). In women with live birth, total Treg cell percentages increased at 8 w (5.52 %, p < 0.001) compared with pre-infusion (4.54 %) and 1 w (4.47 %), while NK cell activity decreased at 1 w (20.18 %, p < 0.001) compared with pre-infusion (26.59 %). IVIG increased Treg cell percentages and suppressed NK cell activity very early in pregnancy, and these were associated with subsequent live birth. Stimulation of Treg cells and suppression of NK cell activity very early in pregnancy may be a mechanism of pharmacological effects of high dose IVIG.

  Aug. 2023, Journal of reproductive immunology, 158, 103977 - 103977, English, International magazine

  Scientific journal


• Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes

  Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Hajime Ota, Shinichiro Wada, Masashi Deguchi, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Gen Kobashi, Hisashi Arase, Hideto Yamada

  Jul. 2023, International Journal of Molecular Sciences, 24(13) (13)

  Scientific journal


• 非認証機関でのNIPTで47,XXYもしくは47,XYYの可能性が指摘され、羊水染色体検査で正常核型の診断となった1例

  益子 尚久, 花房 宏昭, 濱 真奈美, 田中 敬子, 前田 美亜, 冨本 雅子, 今福 仁美, 粟野 宏之, 出口 雅士, 寺井 義人, 野津 寛大

  (一社)日本遺伝カウンセリング学会, Jun. 2023, 日本遺伝カウンセリング学会誌, 44(2) (2), 156 - 156, Japanese


• 4回以上流産を繰り返す原因不明の不育症を対象とした静注免疫グロブリンの二重盲検ランダム化プラセボ対照群間比較試験の成果

  山田 秀人, 出口 雅士, 齋藤 滋, 竹下 俊行, 三井 真理, 齋藤 豪, 永松 健, 高桑 好一, 中塚 幹也, 米田 哲, 江頭 活子, 立花 眞仁, 松原 圭一, 本田 律生, 福井 淳史, 田中 幹二, 千石 一雄, 遠藤 俊明, 矢田 裕朗

  日本生殖免疫学会, Nov. 2022, Reproductive Immunology and Biology, 37(1-2) (1-2), 94 - 94, Japanese


• 4回以上流産を繰り返す原因不明の不育症を対象とした静注免疫グロブリンの二重盲検ランダム化プラセボ対照群間比較試験の成果

  山田 秀人, 出口 雅士, 齋藤 滋, 竹下 俊行, 三井 真理, 齋藤 豪, 永松 健, 高桑 好一, 中塚 幹也, 米田 哲, 江頭 活子, 立花 眞仁, 松原 圭一, 本田 律生, 福井 淳史, 田中 幹二, 千石 一雄, 遠藤 俊明, 矢田 裕朗

  日本生殖免疫学会, Nov. 2022, Reproductive Immunology and Biology, 37(1-2) (1-2), 94 - 94, Japanese


• 梅毒の診療 ベンザチンペニシリンG筋肉注射治療も含め

  今福 仁美, 出口 雅士, 大路 剛, 寺井 義人

  「産婦人科の進歩」編集室, Aug. 2022, 産婦人科の進歩, 74(3) (3), 466 - 468, Japanese


• Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: A double-blind, randomised, placebo-controlled trial.

  Hideto Yamada, Masashi Deguchi, Shigeru Saito, Toshiyuki Takeshita, Mari Mitsui, Tsuyoshi Saito, Takeshi Nagamatsu, Koichi Takakuwa, Mikiya Nakatsuka, Satoshi Yoneda, Katsuko Egashira, Masahito Tachibana, Keiichi Matsubara, Ritsuo Honda, Atsushi Fukui, Kanji Tanaka, Kazuo Sengoku, Toshiaki Endo, Hiroaki Yata

  Background: There is no effective treatment for women with unexplained recurrent pregnancy loss (RPL). We aimed to investigate whether treatment with a high dose of intravenous immunoglobulin (IVIG) in early pregnancy can improve pregnancy outcomes in women with unexplained RPL. Methods: In a double-blind, randomised, placebo-controlled trial, women with primary RPL of unexplained aetiology received 400 mg/kg of IVIG daily or placebo for five consecutive days starting at 4-6 weeks of gestation. They had experienced four or more miscarriages except biochemical pregnancy loss and at least one miscarriage of normal chromosome karyotype. The primary outcome was ongoing pregnancy rate at 22 weeks of gestation, and the live birth rate was the secondary outcome. We analysed all women receiving the study drug (intention-to-treat, ITT) and women except those who miscarried due to fetal chromosome abnormality (modified-ITT). This study is registered with ClinicalTrials.gov number, NCT02184741. Findings: From June 3, 2014 to Jan 29, 2020, 102 women were randomly assigned to receive IVIG (n = 53) or placebo (n = 49). Three women were excluded; therefore 50 women received IVIG and 49 women received placebo in the ITT population. The ongoing pregnancy rate at 22 weeks of gestation (31/50 [62·0%] vs. 17/49 [34·7%]; odds ratio [OR] 3·07, 95% CI 1·35-6·97; p = 0·009) and the live birth rate (29/50 [58·0%] vs. 17/49 [34·7%]; OR 2·60, 95% CI 1·15-5·86; p = 0·03) in the IVIG group were higher than those in the placebo group in the ITT population. The ongoing pregnancy rate at 22 weeks of gestation (OR 6·27, 95% CI 2·21-17·78; p < 0·001) and the live birth rate (OR 4·85, 95% CI 1·74-13·49; p = 0·003) significantly increased in women who received IVIG at 4-5 weeks of gestation as compared with placebo, but these increases were not evident in women who received IVIG at 6 weeks of gestation. Four newborns in the IVIG group and none in the placebo group had congenital anomalies (p = 0·28). Interpretation: A high dose of IVIG in very early pregnancy improved pregnancy outcome in women with four or more RPLs of unexplained aetiology. Funding: The Japan Blood Products Organization.

  Aug. 2022, EClinicalMedicine, 50, 101527 - 101527, English, International magazine

  Scientific journal


• The vaccination status and adverse effects of COVID-19 vaccine among pregnant women in Japan in 2021

  Shihoko Komine-Aizawa, Yasuo Haruyama, Masashi Deguchi, Satoshi Hayakawa, Kei Kawana, Gen Kobashi, Etsuko Miyagi, Hideto Yamada, Takashi Sugiyama

  Jul. 2022, Journal of Obstetrics and Gynaecology Research, 48(7) (7), 1561 - 1569

  Scientific journal


• 妊娠中の副甲状腺摘出により正期産児を得た原発性副甲状腺機能亢進症合併妊娠の一例

  久保田 いろは, 今福 仁美, 益子 尚久, 福岡 秀規, 手島 直則, 谷村 憲司, 出口 雅士, 寺井 義人

  日本女性栄養・代謝学会, May 2022, 日本女性栄養・代謝学会誌, 27(2) (2), 131 - 131, Japanese


• Predictive factors for postpartum glucose intolerance in women with gestational diabetes mellitus.

  Naohisa Masuko, Kenji Tanimura, Nobue Kojima, Hitomi Imafuku, Masashi Deguchi, Yuko Okada, Yushi Hirota, Wataru Ogawa, Hideto Yamada

  AIM: The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM). METHOD: A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75-g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Clinical factors and parameters in the antepartum 75-g OGTT associated with postpartum GI were evaluated by logistic regression analyses. RESULTS: Twenty-two (19.1%) of the 115 women with GDM developed postpartum GI. The univariate and multivariable logistic regression analyses revealed that low oral disposition index (DI) was a risk factor for postpartum GI (OR, 0.2; 95% CI, 0.04-0.7; p < 0.05), and that no clinical factors were associated with postpartum GI. CONCLUSIONS: Lower oral DI on the antepartum 75-g OGTT may be a useful marker for identifying GDM women who are at high risk for postpartum GI.

  Jan. 2022, The journal of obstetrics and gynaecology research, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy.

  Midori Hijikata, Ichiro Morioka, Aya Okahashi, Nobuhiko Nagano, Kaori Kawakami, Atsushi Komatsu, Kei Kawana, Shohei Ohyama, Kazumichi Fujioka, Kenji Tanimura, Masashi Deguchi, Miwa Sasai, Masahiro Yamamoto, Hideto Yamada

  INTRODUCTION: The aims were to investigate the clinical characteristics of Toxoplasma gondii (T. gondii) immunoglobulin (Ig) M-positive mothers and to clarify the incidences of serum T. gondii IgM or blood T. gondii DNA positivity in newborns born to the mothers and the actual congenital T. gondii infection. METHODS: Mothers with T. gondii IgM positivity and newborns born to the mothers from 2013 to 2020 were prospectively investigated. Serum T. gondii IgG and IgM were measured by enzyme-linked immunosorbent assay. Blood T. gondii DNA was detected by semi-nested polymerase chain reaction. Congenital T. gondii infection was diagnosed based on clinical characteristic manifestations with serum T. gondii IgG positivity at any age or T. gondii IgG positivity after 12 months of age. RESULTS: Among 71 T. gondii IgM-positive mothers, including one with triplets, 41% had low T. gondii IgG avidity index and 73% received maternal therapy. Among 73 newborns who were examined for serum T. gondii IgG and IgM at birth, none had clinical manifestations, and one (1.4%) had T. gondii IgM positivity. Among 32 newborns who were examined for blood T. gondii DNA at birth, two (6.3%) were positive. All patients with serum T. gondii IgM or blood T. gondii DNA positivity showed T. gondii IgG negativity within 12 months of age. CONCLUSIONS: A few newborns born to T. gondii IgM-positive mothers were suspected of having congenital T. gondii infection based on serum T. gondii IgM or blood T. gondii DNA testing at birth. However, none developed congenital T. gondii infection.

  Dec. 2021, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 28(4) (4), 486 - 491, English, International magazine

  Scientific journal


• Clinical factors associated with a placenta accreta spectrum.

  Hitomi Imafuku, Kenji Tanimura, Yutoku Shi, Akiko Uchida, Masashi Deguchi, Yoshito Terai

  INTRODUCTION: Placenta accreta spectrum (PAS) is a life-threating obstetric complication, and prenatal prediction of PAS can decrease maternal morbidity and mortality. The aim of this prospective cohort study was to determine the clinical factors associated with PAS. METHODS: Pregnant women who delivered at a university hospital were enrolled. Clinical data were collected from medical records, and logistic regression analyses were performed to determine which clinical factors were associated with PAS. RESULTS: Eighty-seven (2.1%) of the 4146 pregnant women experienced PAS. Multivariable analyses revealed that a prior history of cesarean section (CS) (OR 3.3; 95% CI 1.9-5.7; p < 0.01), dilation and curettage (D&C) (OR 2.8; 95% CI 1.7-4.6; p < 0.01), hysteroscopic surgery (OR 5.7; 95% CI 2.3-14.4; p < 0.01), uterine artery embolization (UAE) (OR 44.1; 95% CI 13.8-141.0; p < 0.01), current pregnancy via assisted reproductive technology (ART) (OR 4.1; 95% CI 2.4-7.1; p < 0.01), and the presence of placenta previa in the current pregnancy (OR 13.1; 95% CI 7.9-21.8; p < 0.01) were independently associated with the occurrence of PAS. CONCLUSION: Pregnant women who have a prior history of CS, D&C, hysteroscopic surgery, UAE, current pregnancy via ART, and the presence of placenta previa in the current pregnancy are high risk for PAS.

  Sep. 2021, Placenta, 112, 180 - 184, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例

  今福 仁美, 谷村 憲司, 益子 尚久, 内田 明子, 藤本 将史, 京野 由紀, 藤岡 一路, 出口 雅士, 寺井 義人

  (一社)日本周産期・新生児医学会, Jun. 2021, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, Japanese


• 胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する

  谷村 憲司, 施 裕徳, 内田 明子, 今福 仁美, 藤岡 一路, 森岡 一朗, 出口 雅士, 峰松 俊夫, 寺井 義人, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2021, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, Japanese


• 症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性の検討

  谷村 憲司, 施 裕徳, 内田 明子, 上中 美月, 今福 仁美, 藤岡 一路, 森岡 一朗, 出口 雅士, 寺井 義人, 山田 秀人

  「産婦人科の進歩」編集室, May 2021, 産婦人科の進歩, 73(2) (2), 152 - 152, Japanese


• トキソプラズマ-IgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例

  谷村 憲司, 内田 明子, 笹川 勇樹, 施 裕徳, 白川 得朗, 今福 仁美, 出口 雅士, 芦名 満理子, 藤岡 一路, 森岡 一朗, 笹井 美和, 山本 雅裕, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 53 - 53, Japanese


• A Novel Autoantibody against β2-Glycoprotein I/HLA Class II Complexes in Antiphospholipid Syndrome

  Kenji Tanimura, Yuki Sasagawa, Masashi Deguchi, Noriko Arase, Hisashi Arase, Hideto Yamada

  We have found that a novel autoantibody against β2-glycoprotein I (β2GPI)/human leukocyte antigen (HLA) class II complexes (anti-β2GPI/HLA-DR) is involved in the pathogenesis of antiphospholipid syndrome (APS). It was also found that many APS patients who were negative for conventional antiphospholipid antibodies (aPLs) possessed anti-β2GPI/HLA-DR. These results suggested that anti-β2GPI/HLA-DR measurements may be more sensitive for diagnosing APS than conventional aPLs tests. Recurrent pregnancy loss (RPL) is one of the clinical manifestations of APS. Therefore, a prospective, multicenter, cross-sectional study were conducted to assess whether anti-β2GPI/HLA-DR is also associated with RPL. This study of 227 couples with RPL revealed that 22.9% (52/227) of RPL women tested positive for anti-β2GPI/HLA-DR, and 24 (19.8%) of the 121 couples with unexplained RPL tested positive for anti-β2GPI/HLA-DR. Interestingly, thirty-five of the 52 (67.3%) RPL patients who were positive for anti-β2GPI/HLA-DR possessed no conventional aPLs of criteria. This novel autoantibody against β2GPI/HLA class II complexes may be a major risk factor for RPL, and it may be a promising biomarker for diagnosing APS.

  IntechOpen, Apr. 2021, Antiphospholipid Syndrome - Recent Advances in Basic and Clinical Aspects [Working Title]

  In book


• 子宮発生腺肉腫の1例 術前PET/MRI画像と病理標本との対比

  山本 雄也, 上野 嘉子, 松田 耕平, 野上 宗伸, 出口 雅士, 上原 慶一郎, 三木 智子, 村上 卓道

  金原出版(株), Apr. 2021, 臨床放射線, 66(4) (4), 381 - 385, Japanese


• Fetal Goitrous Hyperthyroidism in a Pregnant Woman with Triiodothyronine-Predominant Graves' Disease.

  Keiichi Washio, Mizuki Uenaka, Kenji Tanimura, Masashi Deguchi, Kosuke Nishida, Kazumichi Fujioka, Hideto Yamada

  Triiodothyronine (T3)-predominant Graves' disease is characterized by increased serum free T3 (FT3) levels after free thyroxine (FT4) levels become normal or even low during antithyroid drug treatment. We encountered a 34-year-old pregnant woman, gravida 5 para 4, who was complicated by T3-predominant Graves' disease. She was diagnosed with Graves' disease at 20 years old, and had received methimazole. Methimazole was changed to potassium iodide to reduce the risk of congenital anomalies during the first trimester. The dose of antithyroid drugs was adjusted based on maternal FT4 levels, so that maternal Graves' disease deteriorated and fetal goitrous hyperthyroidism appeared during the second trimester. Since the fetus presented goiter and tachycardia at 27-28 gestational weeks, doses of methimazole and potassium iodide were increased. A male newborn weighing 2604 g was delivered by a cesarean section at 35 gestational weeks. The newborn was diagnosed with neonatal hyperthyroidism, and received methimazole for six months. He developed normally with normal thyroid function at 1 year old. In pregnancies complicated by T3-predominant Graves' disease, the kinds and doses of antithyroid drugs have to be carefully selected to maintain maternal levels of FT4 as well as FT3 within the normal range, considering trimesters of pregnancy, teratogenicity of medication, and maternal levels of thyroid-stimulating hormone receptor antibody.

  Feb. 2021, The Kobe journal of medical sciences, 66(4) (4), E153-E158, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Immunoglobulin fetal therapy and neonatal therapy with antiviral drugs improve neurological outcome of infants with symptomatic congenital cytomegalovirus infection.

  Kenji Tanimura, Yutoku Shi, Akiko Uchida, Mizuki Uenaka, Hitomi Imafuku, Toshihiko Ikuta, Kazumichi Fujioka, Ichiro Morioka, Masashi Deguchi, Toshio Minematsu, Hideto Yamada

  Infants with symptomatic congenital cytomegalovirus infection (cCMV) suffer from long-term sequelae. This study aimed at evaluating the efficacy of combining immunoglobulin (Ig) fetal therapy (FT) and neonatal therapy (NT) with antiviral drugs to improve neurological outcomes of affected infants. Women whose fetuses had symptomatic cCMV received Ig injection into the fetal peritoneal cavity and/or maternal blood as FT, while affected newborns received oral valganciclovir or intravenous ganciclovir as NT. We compared the neurological outcomes at ≥18 months old between infants receiving FT with or without NT (FT group) and those receiving NT only (NT group). From 2009-2019, 15 women whose fetuses had symptomatic cCMV received FT, while 19 newborns received NT only. In FT group, two newborns died, and two were <18 months old. Neurological outcomes of the remaining 11 infants in FT group were as follows: normal 45.5 %, mild impairments 36.4 %, and severe impairments 18.2 %. In NT group, one newborn died, one's parents refused the follow-up, one was <18 months old, and two had only chorioretinitis as symptoms. Neurological outcomes of the remaining 14 infants in NT group were as follows: normal 21.4 %, mild impairments 14.3 %, and severe impairments 64.3 %. The proportion of infants with severe impairments in FT group was significantly lower than that in NT group (18.2 % vs 64.3 %, p < 0.05). This is the first trial demonstrating that the combination of Ig FT and NT with antiviral drugs may be more effective in improving neurological outcomes of newborns with symptomatic cCMV as compared to NT only.

  Dec. 2020, Journal of reproductive immunology, 143, 103263 - 103263, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【不妊・不育症女性の合併症・併存疾患をどう扱う?】血栓性素因

  出口 雅士, 谷村 憲司, 蝦名 康彦, 山田 秀人

  金原出版(株), Dec. 2020, 産婦人科の実際, 69(13) (13), 1605 - 1614, Japanese


• Clinical and ultrasound features associated with congenital cytomegalovirus infection as potential predictors for targeted newborn screening in high-risk pregnancies.

  Hitomi Imafuku, Hideto Yamada, Akiko Uchida, Masashi Deguchi, Tokuro Shirakawa, Yuki Sasagawa, Yutoku Shi, Kazumichi Fujioka, Ichiro Morioka, Kenji Tanimura

  This prospective cohort study aimed to determine clinical factors associated with congenital cytomegalovirus (CMV) infection in pregnancy. Newborns born at a perinatal medical center received PCR analyses for CMV-DNA in their urine with informed consent. Clinical data, including age, maternal fever or flu-like symptoms, complications, ultrasound fetal abnormality, gestational weeks at delivery, and birth weight, were collected. Logistic regression analyses determined clinical findings associated with congenital CMV infection (cCMV). cCMV was diagnosed in 32 of 4380 pregnancies. Univariate and multivariable analyses revealed that age < 25 years old (OR 2.7, 95% CI 1.1-6.6; p < 0.05), the presence of maternal fever or flu-like symptoms (5.4, 2.6-11.2; p < 0.01), ultrasound fetal abnormalities (12.7, 5.8-27.7; p < 0.01), and preterm delivery at less than 34 gestational weeks (2.6, 1.1-6.0; p < 0.05) were independent clinical findings associated with cCMV. A combination of maternal fever/flu-like symptoms, ultrasound fetal abnormalities, or preterm delivery at less than 34 gestational weeks as optimal predictive factors showed 90.6% sensitivity, 66.4% specificity, and a maximum Youden index of 0.57. CMV-DNA tests in the urine of newborns born to mothers with these clinical manifestations may be an effective method in detecting cCMV as a targeted screening with a high sensitivity.

  Nov. 2020, Scientific reports, 10(1) (1), 19706 - 19706, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The beta(2)-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome

  Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada

  Nov. 2020, ARTHRITIS & RHEUMATOLOGY, 72(11) (11), 1882 - 1891, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The β 2 -Glycoprotein I/HLA-DR Complex As a Major Autoantibody Target in Obstetric Antiphospholipid Syndrome.

  Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada

  OBJECTIVE: The clinical manifestations of antiphospholipid syndrome (APS) include vascular thrombosis and pregnancy morbidity as well as recurrent pregnancy loss (RPL). However, in more than half of patients with RPL, the cause is never determined. Recently, β2 -glycoprotein I (β2 GPI) complexed with HLA class II molecules (β2 GPI/HLA-DR) was found to be a major autoantibody target in APS. The present study was undertaken to assess the serum levels of autoantibodies against the β2 GPI/HLA II complex as a potential risk factor for RPL in women. METHODS: Serum levels of antiphospholipid antibodies (aPLs), including IgG/IgM anticardiolipin antibodies, IgG/IgM anti-β2 GPI antibodies, and lupus anticoagulant as well as anti-β2 GPI/HLA-DR antibodies, were measured in 227 women with RPL. In this prospective, multicenter, cross-sectional study, women with RPL and their partners underwent HLA-DR immunotyping and analysis to identify potential causes and risk factors associated with RPL. The normal range for anti-β2 GPI/HLA-DR antibody levels was determined using serum samples obtained from a control population of female subjects (208 women of childbearing potential). RESULTS: Of the 227 women with RPL, aPL antibodies were detected in 19.8%, and 52 (22.9%) tested positive for anti-β2 GPI/HLA-DR antibodies. Among the 227 women, 121 (53.3%) had no risk factors for RPL, and among these women with unexplained RPL, 24 (19.8%) were positive for anti-β2 GPI/HLA-DR antibodies. Of the 112 women who had clinical symptoms of APS but did not have levels of aPLs that met the diagnostic criteria for APS, 21 (18.8%) were positive for anti-β2 GPI/HLA-DR antibodies. CONCLUSION: The anti-β2 GPI/HLA-DR antibody is frequently associated with RPL. Detection of these autoantibodies is useful in understanding the pathogenesis of RPL. Our findings may provide potential new therapeutic strategies for addressing RPL in patients with obstetric APS.

  Nov. 2020, Arthritis & rheumatology (Hoboken, N.J.), 72(11) (11), 1882 - 1891, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A cohort study of the universal neonatal urine screening for congenital cytomegalovirus infection.

  Hideto Yamada, Kenji Tanimura, Sachiyo Fukushima, Kazumichi Fujioka, Masashi Deguchi, Yuki Sasagawa, Shinya Tairaku, Toru Funakoshi, Ichiro Morioka

  OBJECTIVES: This prospective cohort study aimed to evaluate the efficacy of the universal neonatal urine screening, followed by diagnosis, workup and antiviral therapy for symptomatic congenital cytomegalovirus (CMV) infection to reduce neurological impairments and sequelae. METHODS: Neonates born in three facilities underwent the universal urine screening of PCR analyses for CMV-DNA. Neonates with symptomatic congenital CMV infection (cCMV) received oral valganciclovir (VGCV) of 32 mg/kg/day for six weeks or six months, and were evaluated for neurological outcomes including developmental quotient (DQ) and hearing function at around 18 months of corrected age. RESULTS: cCMV was diagnosed in 56 (0.48%) of 11,736 neonates, consisting of 23 neonates with symptomatic and 33 with asymptomatic cCMV. The incidence of cCMV in the general perinatal medical center (0.69%) was higher than that in the primary maternity hospital (0.23%, p<0.01%). Twenty of the 23 infants with symptomatic cCMV received VGCV therapy, and 19 underwent neurological assessment. Eight neonates (42%) had severe sequelae of DQ < 70, bilateral hearing dysfunction, and/or epilepsy. Four neonates (21%) had mild sequelae of DQ 70-79 or unilateral hearing dysfunction only, and seven (37%) showed normal development without any impairment. CONCLUSIONS: This study on a large scale demonstrated that a series of universal neonatal urine screening, diagnosis, workup, and VGCV therapy for neonates with symptomatic cCMV may decrease neurological impairments, because 58% of the treated infants had normal development or mild sequelae. The universal urine screening likely identifies subclinical symptomatic cCMV. Mothers with fetuses of cCMV seem to be selectively transferred to perinatal medical centers before deliveries.

  Apr. 2020, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 26(8) (8), 790 - 794, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• イリノテカン+シスプラチン療法が奏功した局所進行子宮頸部小細胞癌の一例

  安積 麻帆, 鈴木 嘉穂, 出口 雅士, 松本 培世, 長又 哲史, 高橋 良輔, 蝦名 康彦, 寺井 義人

  (公社)日本婦人科腫瘍学会, Apr. 2020, 日本婦人科腫瘍学会雑誌, 38(2) (2), 193 - 199, Japanese


• A Case of Significant Response to Olaparib in a Patient with Primary Peritoneal Carcinosarcoma Diagnosed by Laparoscopic Surgery.

  Satoshi Nagamata, Yukiko Nakasuji, Keitaro Yamanaka, Maho Azumi, Keiichi Washio, Maho Shimizu, Ryosuke Takahashi, Kazuyo Matsumoto, Yuka Murata, Kaho Suzuki, Masashi Deguchi, Hideto Yamada, Yoshito Terai

  Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.

  2020, Case reports in obstetrics and gynecology, 2020, 9106390 - 9106390, English, International magazine


• Prediction of poor neurological development in patients with symptomatic congenital cytomegalovirus diseases after oral valganciclovir treatment.

  Sachiyo Fukushima, Ichiro Morioka, Shohei Ohyama, Kosuke Nishida, Sota Iwatani, Kazumichi Fujioka, Tsurue Mandai, Hisayuki Matsumoto, Yuji Nakamachi, Masashi Deguchi, Kenji Tanimura, Kazumoto Iijima, Hideto Yamada

  OBJECTIVE: This study aimed to evaluate the neurodevelopmental outcomes of infants with symptomatic congenital cytomegalovirus (SCCMV) disease after antiviral treatment and investigate the symptoms at birth associated with a developmental quotient (DQ) < 70. METHODS: In this prospective study conducted from 2009 to 2018, infants with SCCMV disease who received oral valganciclovir (VGCV; 32 mg/kg/day) for 6 weeks (November 2009 to June 2015) or 6 months (July 2015 to March 2018) were evaluated for their neurodevelopmental outcomes at around 18 months of corrected age. Sequelae were categorized as follows: no impairment with a DQ ≥ 80 and no hearing dysfunction; mild sequelae including unilateral hearing dysfunction or a DQ of 70-79; and severe sequelae with a DQ < 70, bilateral hearing dysfunction requiring hearing aids, blindness or epilepsy requiring anti-epileptic drugs. DQ was assessed using the Kyoto Scale of Psychological Development. Symptoms at birth associated with a DQ < 70 were determined using univariate and receiver operating characteristic curve analyses. RESULTS: Of the 24 treated infants, 21 reached > 18 months of corrected age. Six (29%) were no impairment, 4 (19%) had mild sequelae, and 11 (52%) developed severe sequelae. The symptoms at birth associated with a DQ < 70 were microcephaly and/or small for gestational age. CONCLUSION: In our cohort of infants with SCCMV disease after VGCV treatment, the incidence of severe sequelae at 18 months of corrected age was around 50%. When microcephaly and/or small for gestational age are seen at birth, a low DQ may appear even after oral VGCV treatment.

  Oct. 2019, Brain & development, 41(9) (9), 743 - 750, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性

  谷村 憲司, 内田 明子, 今福 仁美, 森實 真由美, 出口 雅士, 藤岡 一路, 森岡 一朗, 峰松 俊夫, 山田 秀人

  (一社)日本産婦人科感染症学会, Sep. 2019, 日本産婦人科感染症学会誌, 3(1) (1), 87 - 87, Japanese


• Hepatitis B virus infection: Prevention of mother-to-child transmission and exacerbation during pregnancy.

  Sasagawa Y, Yamada H, Morizane M, Deguchi M, Shirakawa T, Morioka I, Tanimura K

  The aims of this study were to assess the effect of maternal screening for hepatitis B (HB) virus and a perinatal prevention program of mother-to-child transmission, and to identify clinical characteristics and findings associated with HB exacerbation during pregnancy. This prospective cohort study enrolled 3796 pregnant women and their neonates with informed consent. Pregnant women underwent maternal universal screening for HBs antigen (Ag) in the first trimester. If HBs Ag was positive, serum levels of HBe Ag, alanine transaminase (AST), aspartate aminotransferase (ALT), and HB virus (HBV) DNA were measured. All neonates delivered from HBs Ag-positive women were given HB immune globulin and HB vaccine based on the guidelines of the perinatal prevention program. Of the 3796 pregnant women, 40 (1.05%) tested positive for HBs Ag. Three (7.5%) of the 40 HBs Ag-positive women experienced exacerbation of HBV infection during pregnancy. Serum levels of AST (median 776 vs. 22 mIU/ml, p < 0.01), ALT (median 325 vs. 15 mIU/ml, p < 0.01), and HBV-DNA (median 9.1 vs. 5.4 log copies/ml, p < 0.05), and frequencies of HBe Ag-positive (100% vs. 29.7%, p < 0.05) and symptoms of itching or general fatigue (66.7% vs. 0%, p < 0.01) in three women with exacerbation of HBV infection were significantly higher than those in 37 women without exacerbation. There was no case of mother-to-child transmission, suggesting the perinatal HBV prevention program was effective. Levels of HBe Ag, liver enzymes, and HBV-DNA as well as symptoms of itching and general fatigue should be carefully monitored for HBs Ag-positive women during pregnancy and the postpartum period.

  Aug. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 25(8) (8), 621 - 625, English, International magazine

  [Refereed]

  Scientific journal


• 卵巣癌患者における治療前Prognostic nutritional indexと予後

  蝦名 康彦, 長又 哲史, 鈴木 嘉穂, 若橋 宣, 宮原 義也, 出口 雅士, 山田 秀人

  日本女性栄養・代謝学会, Jun. 2019, 日本女性栄養・代謝学会誌, 25(1) (1), 49 - 50, Japanese


• A cohort study of maternal screening for congenital Toxoplasma gondii infection: 12 years' experience.

  Hideto Yamada, Kenji Tanimura, Masashi Deguchi, Shinya Tairaku, Mayumi Morizane, Akiko Uchida, Yasuhiko Ebina, Akira Nishikawa

  Primary infection with Toxoplasma gondii (T. gondii) during pregnancy may cause congenital infection of the infant. This study evaluated whether screening using IgG avidity and multiplex-nested polymerase chain reaction (PCR) methods was effective for detecting a high-risk pregnancy for congenital T. gondii infection. In a prospective cohort study serum T. gondii IgG avidity was measured in 469 pregnant women who had a positive test for T. gondii antibody plus a positive or equivocal test for IgM. Multiplex-nested PCR for T. gondii DNA on amniotic fluid, maternal blood, and neonatal blood was performed with informed consent. Low (<30%), borderline (30-35%), and high (>35%) IgG avidity indices were found in 104 (22.2%), 30 (6.4%), and 305 (71.4%), respectively. A total of 12 cases had a positive PCR test for amniotic fluids of the prenatal amniocentesis or at birth, or neonatal blood. Seven of the 12 cases were diagnosed as having congenital T. gondii infection, and they had low IgG avidity indices. Congenital T. gondii infection screening using of IgG avidity and multiplex-nested PCR methods for pregnant women with a positive test for T. gondii antibody plus a positive or equivocal test for T. gondii IgM was useful for detecting a high-risk pregnancy and diagnosing congenital T. gondii infection.

  Jun. 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 25(6) (6), 427 - 430, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical factors associated with pregnancy outcome in women with recurrent pregnancy loss.

  Maho Miyaji, Masashi Deguchi, Kenji Tanimura, Yuki Sasagawa, Mayumi Morizane, Yasuhiko Ebina, Hideto Yamada

  The aim of this prospective cohort study was to evaluate clinical factors associated with pregnancy outcomes in women with recurrent pregnancy loss (RPL). Women with a history of two or more pregnancy losses underwent workups for clinical factors of RPL and their pregnancies were followed-up with informed consent. Two hundred eleven (81.5%) of 259 women with RPL became pregnant. The multivariable analyses demonstrated that age (p < .01, OR 0.9, 95%CI 0.97-0.83), uterine abnormality (p < .05, OR 0.3, 95%CI 0.11-0.8), and protein C (PC) deficiency (p < .01, OR 0.14, 95%CI 0.03-0.6) were independent factors for becoming pregnancy in women with RPL. The number of previous pregnancy loss (p < .01, OR 0.57, 95%CI 0.43-0.75) and natural killer (NK) cell activity ≥33% (p < .01, OR 0.31, 95%CI 0.13-0.73) were independent factors for live birth in the subsequent pregnancy. Advanced age, the presence of uterine abnormality, and PC deficiency were risk factors for reduced pregnancy rate in women with RPL. Increased number of previous pregnancy loss and high NK cell activity were risk factors for miscarriage in the subsequent pregnancy. These results involve important information and are helpful for clinical practitioners.

  Apr. 2019, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 35(10) (10), 1 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Efficacy of Valganciclovir Treatment Depends on the Severity of Hearing Dysfunction in Symptomatic Infants with Congenital Cytomegalovirus Infection.

  Shohei Ohyama, Ichiro Morioka, Sachiyo Fukushima, Keiji Yamana, Kosuke Nishida, Sota Iwatani, Kazumichi Fujioka, Hisayuki Matsumoto, Takamitsu Imanishi, Yuji Nakamachi, Masashi Deguchi, Kenji Tanimura, Kazumoto Iijima, Hideto Yamada

  Although earlier studies have shown that antiviral treatment regimens using valganciclovir (VGCV) improved hearing function in some infants with congenital cytomegalovirus (CMV) infection; its efficacy on the severity of hearing dysfunction is unclear. We conducted a prospective study among 26 infants with congenital CMV infections from 2009 to 2018. Oral VGCV (32 mg/kg/day) was administered for 6 weeks (November 2009 to June 2015; n = 20) or 6 months (July 2015 to March 2018, n = 6). Hearing function was evaluated by measuring the auditory brainstem response before VGCV treatment and at 6 months. Hearing dysfunction, defined as a V-wave threshold >40 dB, was categorized into: most severe, ≥91 dB; severe, 61⁻90 dB; and moderate, 41⁻60 dB. Hearing improvement was defined as a decrease of ≥20 dB from the pretreatment V-wave threshold. Of 52 ears in 26 infants with congenital CMV infection, 29 (56%) had hearing dysfunction, and of 29 ears, 16 (55%) improved after VGCV treatment. Although, 16 (84%) of 19 ears with moderate or severe hearing dysfunction improved after treatment (p < 0.001), 10 ears with the most severe form did not. In conclusion, VGCV treatment is effective in improving moderate and severe hearing dysfunction in infants with congenital CMV infection.

  Mar. 2019, International journal of molecular sciences, 20(6) (6), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Neonatal Alloimmune Thrombocytopenia: A Report of Four Cases.

  Uenaka M, Morizane M, Tanimura K, Deguchi M, Ebina Y, Hashimoto M, Morioka I, Yamada H

  Antibodies against fetal platelet alloantigens in maternal blood cause neonatal alloimmune thrombocytopenia (NAIT). We encountered four newborns with NAIT from three women. A woman carried anti-human platelet antigen (HPA)-1a antibody, and vaginally delivered a newborn who had subarachnoid hemorrhage and platelet transfusions. She delivered the second newborn by a cesarean section who had no symptom. The second woman carried anti-human leukocyte antigen-A2 antibody and vaginally delivered a newborn who had no symptom. The third woman with a history of recurrent pregnancy losses carried anti-HPA-4b antibody, and delivered a newborn by a cesarean section who received platelet transfusions and immunoglobulin infusions. Antiplatelet antibody screening may be helpful in women who have a history of blood transfusion, or previous neonates with thrombocytopenia or intracranial hemorrhage.

  Mar. 2019, The Kobe journal of medical sciences, 64(6) (6), E197 - E199, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【妊娠高血圧症候群-PIHからHDPへ】 抗リン脂質抗体と妊娠高血圧症候群

  Deguchi Masashi, 谷村憲司, 山田秀人

  (株)診断と治療社, Feb. 2019, 産科と婦人科, 86(2号) (2号), 223 - 229, Japanese

  [Invited]


• Fetal Primary Small Bowel Volvulus Associated with Acute Gastric Dilatation Detected by Ultrasonography.

  Sachiyo Fukushima, Kazumichi Fujioka, Mariko Ashina, Shohei Ohyama, Toshihiko Ikuta, Kosuke Nishida, Harunori Miyauchi, Yuichi Okata, Yuko Bitoh, Kenji Tanimura, Masashi Deguchi, Hideto Yamada, Kazumoto Iijima

  Fetal intestinal volvulus is a rare condition, and fetal diagnosis of this disease is still challenging, especially in primary cases not accompanied by other comorbidities, such as intestinal malformations. Herein, we report a case of fetal primary small bowel volvulus associated with acute gastric dilatation detected by ultrasonography. We speculate that the mechanism of acute gastric dilatation in our case was peristatic malfunction of the whole intestine caused by a strangulated ileus resulting from fetal intestinal volvulus. In conclusion, acute gastric dilatation detected by fetal ultrasound can indicate the fetal intestinal volvulus.

  Jan. 2019, The Kobe journal of medical sciences, 64(4) (4), E157-E159 - E159, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Histopathological analysis of placentas with congenital cytomegalovirus infection.

  Mizuki Uenaka, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Maki Kanzawa, Tomoo Itoh, Hideto Yamada

  INTRODUCTION: Cytomegalovirus (CMV) infection is the most common cause of congenital viral infections in humans. The unusual structure of the placenta plays a pivotal role in CMV transmission from mothers to fetuses. The aim of this study was to evaluate the histopathological findings of placentas with congenital CMV infections. METHODS: We obtained placental specimens from 35 women who had newborns with congenital CMV infections. Placental specimens, extraplacental membranes, and umbilical cords were stained with hematoxylin and eosin, and subjected to immunohistochemical analysis. We evaluated the localization of CMV-infected cells and other histological parameters. RESULTS: Thirty (86%) of the 35 placentas tested positive for CMV-infected cell proteins by immunohistochemistry. A majority of CMV-positive cells were present in fibroblasts and endothelial cells in the villi. The number of CMV-infected cells was inversely correlated to gestational age at delivery. The frequency of chronic villitis (65% vs. 11%; p < 0.01) and changes of the villi (38% vs. 0%; p < 0.05) in the placentas from mothers with symptomatic congenital CMV infections was higher than those observed in samples from mothers with asymptomatic congenital infections. The frequency of changes of the decidua (43% vs. 5%; p < 0.01) in the placentas from mothers with non-primary CMV infections was higher than those from mothers with primary infections. DISCUSSION: Chronic villitis and changes of the villi were associated with symptomatic congenital CMV infections. The changes of the decidua were associated with congenital CMV infections, in mothers with non-primary CMV infections.

  Jan. 2019, Placenta, 75, 62 - 67, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 妊婦のB型肝炎スクリーニングと垂直感染予防

  笹川勇樹, Tanimura Kenji, 森實真由美, Deguchi Masashi, 山田秀人

  2008年から7月から2016年12月までにHBs抗原検査を行い、分娩した妊婦3796名とその新生児を対象に、前向き研究を実施した。B型肝炎(HBV)キャリア妊婦における妊娠中のB型肝炎増悪(Flare)の発生頻度および臨床的特徴、HBVスクリーニングによる母子感染予防対策の有用性も調査した。対象となったHBs抗原陽性40名を分析対象とした。HBs抗原陽性妊婦からの出生児40名中、転院5名を除く35名に垂直感染予防策が完遂されて、全例で垂直感染は見られなかった。分析対象40名のうち、3名(7.5%)でFlareがみられ、Flareがみられた3名中2名で皮膚そう痒感や全身倦怠感などの臨床症状を呈し、3名ともHBV-DNA量が増加した。HBVスクリーニングによる母子感染予防対策は有効であると考えられた。HBs抗原陽性妊婦がFlareを起こすことは稀ではなく、劇症化する場合もあり、内科のある高次施設での妊娠管理が望ましいと考えられた。

  兵庫県母性衛生学会, Dec. 2018, 兵庫県母性衛生学会雑誌, (27号) (27号), 67 - 68, Japanese

  [Refereed]


• Clinical factor associated with congenital cytomegalovirus infection in pregnant women with non-primary infection.

  Hideto Yamada, Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Masashi Deguchi, Mayumi Morizane, Satoshi Nagamata, Kana Ozaki, Yasuhiko Ebina, Toshio Minematsu

  The aim of this nested case-control study was to evaluate clinical factors associated with the occurrence of congenital cytomegalovirus (CMV) infection in pregnant women with non-primary CMV infection. In a cohort study of CMV screening for 2193 pregnant women and their newborns, seven newborns with congenital CMV infection were identified among 1287 pregnant women with non-primary CMV infection that was defined as negative IgM and positive IgG with IgG avidity index >45%. In the 1287 women with non-primary CMV infection, clinical findings and complications were compared between pregnancies with and without congenital CMV infection. Clinical factors associated with the occurrence of congenital CMV infection were evaluated. The birth weight of newborns with congenital CMV infection was less than that of newborns without congenital infection (p < 0.05). Univariate logistic regression analyses demonstrated that threatened premature delivery (OR 10.6, 95%CI 2.0-55.0; p < 0.01) and multiple pregnancy (OR 7.1, 95%CI 1.4-37.4; p < 0.05) were associated with congenital infection. Multivariable logistic regression analyses demonstrated that threatened premature delivery (OR 8.4, 95%CI 1.5-48.1; p < 0.05) was a single risk factor for congenital CMV infection in pregnant women with non-primary CMV infection. This study revealed for the first time that threatened premature delivery was associated with the occurrence of congenital CMV infection in pregnant women with non-primary CMV infection, the pathophysiology of which may be closely associated with CMV reactivation during pregnancy.

  Sep. 2018, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 24(9) (9), 702 - 706, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 在胎30週未満の胎児発育不全児における予後不良に関連する因子の検討

  内山美穂子, Tanimura Kenji, 白國あかり, 森實真由美, Deguchi Masashi, Fujioka Kazumichi, 森岡一朗, Yamada Hideto

  妊娠30週未満で分娩となった胎児発育不全児(FGR)16例を対象に、予後不良に関連する因子について検討した。その結果、後遺症なし生存中の予後良好群は8例、後遺症あり生存または、子宮内胎児死亡、新生児死亡の予後不良群は8例であった。予後良好群に比べ予後不良群では、妊娠回数が少なく、FGR診断時胎児推定体重のSD値が小さく、高度の胎児血流異常ありの割合が高かった。FGRの原因やリスク因子としては妊娠高血圧症候群が62.4%を占めていた。また、FGR診断後にHDP(妊娠高血圧症候群)を発症した症例もみられた。

  「産婦人科の進歩」編集室, Aug. 2018, 産婦人科の進歩, 70(3) (3), 270 - 277, Japanese

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 当院における先天性トキソプラズマ感染症の発生に関する臨床前向き研究

  大山 正平, 森岡 一朗, 福嶋 祥代, 芦名 満理子, 生田 寿彦, 大久保 沙紀, 山名 啓司, 藤岡 一路, 森實 真由美, 出口 雅士, 谷村 憲司, 飯島 一誠, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 621 - 621, Japanese


• 症候性先天性CMV感染児の1歳6ヵ月時点でのDQ<70と関連する周産期リスク因子の後方視的検討

  福嶋 祥代, 森岡 一朗, 芦名 満理子, 生田 寿彦, 大山 正平, 大久保 沙紀, 山名 啓司, 藤岡 一路, 森實 真由美, 出口 雅士, 谷村 憲司, 飯島 一誠, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 622 - 622, Japanese


• 尿サイトメガロウイルス(CMV)スクリーニングで同定した先天性CMV感染児の前方視的観察研究

  福嶋 祥代, 森岡 一朗, 芦名 満理子, 生田 寿彦, 大山 正平, 大久保 沙紀, 山名 啓司, 藤岡 一路, 森實 真由美, 出口 雅士, 谷村 憲司, 船越 徹, 大橋 正伸, 飯島 一誠, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 622 - 622, Japanese


• Classification of uterine artery angiographic images: a predictive factor of failure in uterine artery embolization for postpartum hemorrhage.

  Eisuke Ueshima, Koji Sugimoto, Takuya Okada, Naoto Katayama, Yutaka Koide, Keitaro Sofue, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Masato Yamaguchi

  PURPOSE: To justify a classification system for angiographic images of uterine artery embolization (UAE) for postpartum hemorrhage (PPH) and identify new risk factors associated with failed embolization. MATERIALS AND METHODS: A retrospective analysis of 63 consecutive patients who underwent UAE for severe PPH was performed. Uterine artery angiography (UA) before embolization was classified into two types: type 1 was defined as complete staining and type 2 was defined as partial staining of the uterine arteries. The clinical outcome, UA classification, and other possible factors previously reported were evaluated. Univariate and multivariate analyses were performed to determine the factors related to clinical outcomes. RESULTS: Sixty-three patients were enrolled (type 1, 22; type 2, 41). The clinical success rates of the primary UAE session were 90.9% (20/22) for type 1 and 61.0% (25/41) for type 2 (p = 0.018). Univariate and multivariate analyses demonstrated that the only UA classification was significantly associated with primary UAE failure (p = 0.033). CONCLUSIONS: The UA classification is an independent predictive factor of the clinical success rate of the primary UAE session for PPH; thus, it is an intuitive and optimal predictor for interventional radiologists to decide whether additional therapy is necessary.

  Jun. 2018, Japanese journal of radiology, 36(6) (6), 394 - 400, English, Domestic magazine

  [Refereed]

  Scientific journal


• トラベクテジンにより長期間病勢コントロールを行った平滑筋肉腫の1例

  長又 哲史, 蝦名 康彦, 鈴木 嘉穂, 若橋 宣, 宮原 義也, 出口 雅士, 山田 秀人

  「産婦人科の進歩」編集室, May 2018, 産婦人科の進歩, 70(2) (2), 234 - 234, Japanese


• 子宮頸部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討

  白國 あかり, 荻野 美智, 出口 雅士, 蝦名 康彦, 上中 美月, 鈴木 嘉穂, 若橋 宣, 宮原 義也, 山田 秀人

  「産婦人科の進歩」編集室, May 2018, 産婦人科の進歩, 70(2) (2), 239 - 239, Japanese


• PPAPスコアリングシステムを用いた前置胎盤の管理

  谷村憲司, 森實真由美, 出口雅士, Ueno Yoshiko, 山田秀人

  「産婦人科の進歩」編集室, May 2018, 産婦人科の進歩, 70(2) (2), 218 - 218, Japanese


• Effectiveness of high-dose i.v. immunoglobulin therapy for pregnant women with aspirin-heparin-resistant secondary antiphospholipid syndrome.

  Yoko Maesawa, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Yasuhiko Ebina, Hideto Yamada

  Purpose: This study aimed to assess the efficacy of high-dose i.v. immunoglobulin (HIVIg) therapy in pregnant women with antiphospholipid syndrome (APS) secondary to systemic lupus erythematosus with a history of pregnancy failure, despite receiving low-dose aspirin plus unfractionated heparin therapy, of which condition being designated as "aspirin-heparin-resistant APS" (AHRAPS). Methods: The HIVIg therapy (20 g/d, 5 days) was performed for the pregnancies of five women with AHRAPS. Results: Five of the eight pregnancies ended in live births. The gestational ages of delivery in four of the five pregnancies were extended, compared with previous pregnancies. The HIVIg therapy was considered to be successful for these four pregnancies. Excluding one pregnancy that ended in miscarriage with an abnormal chromosome karyotype of the villi, the HIVIg therapy was considered to be successful in four (57.1%) of the seven pregnancies of the women with AHRAPS. Although all the live newborns were prematurely delivered, no adverse effect of the HIVIg therapy was observed. Conclusions: The HIVIg therapy might be beneficial as an immune modifier for pregnant women with AHRAPS. However, the precise indication of which women with AHRAPS who should receive HIVIg therapy remains unknown.

  Apr. 2018, Reproductive medicine and biology, 17(2) (2), 149 - 154, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A novel scoring system for predicting adherent placenta in women with placenta previa.

  Kenji Tanimura, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Utaru Tanaka, Yoshiko Ueno, Kazuhiro Kitajima, Tetsuo Maeda, Kazuro Sugimura, Hideto Yamada

  INTRODUCTION: Placenta previa (PP) is one of the most significant risk factors for adherent placenta (AP). The aim of this study was to evaluate the diagnostic efficacy of a novel scoring system for predicting AP in pregnant women with PP. METHODS: This prospective cohort study enrolled 175 women with PP. The placenta previa with adherent placenta score (PPAP score) is composed of 2 categories: (1) past history of cesarean section (CS), surgical abortion, and/or uterine surgery; and (2) ultrasonography and magnetic resonance imaging findings. Each category is graded as 0, 1, 2, or 4 points, yielding a total score between 0 and 24. When women with PP had PPAP score ≥8, they were considered to be at a high risk for AP and received placement of preoperative internal iliac artery occlusion balloon catheters. If they were found to have AP during CS, they underwent hysterectomy or placenta removal using advanced bipolar with balloon catheter occlusion. The predictive accuracy of PPAP score was evaluated. RESULTS: In total, 23 of the 175 women with PP were diagnosed as having AP, histopathologically or clinically. Twenty-one of 24 women with PPAP score ≥8 had AP, whereas two of 151 women with PPAP score <8 had AP. The scoring system yielded 91.3% sensitivity, 98.0% specificity, 87.5% positive predictive value, and 98.7% negative predictive value for predicting AP in women with PP. DISCUSSION: This prospective study demonstrated that PPAP scoring system may be useful for predicting AP in women with PP.

  Apr. 2018, Placenta, 64, 27 - 33, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Case of Congenital Complete Atrioventricular Block Treated with Transdermal Tulobuterol

  Ikuta T, Fujioka Kazumichi, Sato Y, Ashina M, FukushimaS, Ohyama S, Okubo S, Yamana K, Morizane M, Tanimura Kenji, Deguchi Masashi, IIJIMA KAZUMOTO, Morioka I, Yamada Hideto

  Congenital complete atrioventricular block (CCAVB) is a condition in which the atria and ventricles beat independently of each other. CCAVB cases require permanent pacemaker implantation until adulthood. Nevertheless, consensus regarding postnatal medical therapy for bradycardia has not been reached. Here we report the case of a newborn with CCAVB, whose intractable bradycardia was successfully treated with transdermal tulobuterol. Tulobuterol is a selective β2-adrenoceptor agonist, widely used safely as bronchodilator in children. It also has positive inotropic and chronotropic effect via β1-adrenoceptors. We believe the tulobuterol patch can be used as an optional therapy for CCAVB where pacemaker implantation is not available.

  Apr. 2018, Kobe J Med Sci, 63(4) (4), E109 - E112, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus.

  Masashi Deguchi, Yoko Maesawa, Shino Kubota, Mayumi Morizane, Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada

  The aim of this prospective study was to determine clinical factors associated with adverse pregnancy outcomes in women with systematic lupus erythematosus (SLE). Fifty-six pregnancies from 46 women with SLE were enrolled. Risk factors for pregnancy loss, premature delivery, hypertensive disorders of pregnancy (HDP), and light-for-date neonate (LFD), were evaluated. Univariate and multivariate logistic regression analyses revealed a history of two or more pregnancy losses before 10 gestational weeks (GW) (OR 11.5, 95%CI 1.72-76.8) as a risk factor for pregnancy loss; low levels of blood complements (OR 7.55, 95%CI 1.10-51.9) and antiphospholipid syndrome (OR 26.5, 95%CI 3.17-219) as risk factors for premature delivery before 37 GW; SLEDAI score at conception (OR 1.68, 95%CI 1.05-2.68) and positive tests for two or more antiphospholipid antibodies (OR 6.89, 95%CI 1.13-41.9) as risk factors for premature delivery before 34 GW; prednisolone therapy >14mg/day (OR 7.55, 95%CI 1.10-51.9) as a risk factor for HDP; and low dose aspirin therapy (OR 0.21, 95%CI 0.05-0.97) decreased the risk for LFD neonate. These results have important implications for clinicians managing SLE complicated pregnancy.

  Feb. 2018, Journal of reproductive immunology, 125, 39 - 44, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Decidual CD68+ HLA-DR+ CD163- M1 macrophages increase in miscarriages with normal fetal chromosome.

  Shigeki Shimada, Yasuhiko Ebina, Norifumi Iijima, Masashi Deguchi, Hideto Yamada

  PROBLEM: Is an abnormal increase or decrease of M1/M2 macrophages observed in the deciduae of miscarriages with normal fetal chromosome (MN)? METHODS OF STUDY: Deciduae of 18 MN and 26 miscarriages with abnormal fetal chromosome (MA) were obtained. Additionally, deciduae from 15 women whose pregnancies ended in induced abortions (IA) and endometriums at the mid-luteal phase from 19 non-pregnant women endomeriums of mid-luteal phases (EM) were obtained. Macrophages were analyzed by flow cytometry using monoclonal antibodies for CD68, HLA-DR, and CD163. RESULTS: M1 macrophages, defined as CD68+ HLA-DR+ CD163- cells, increased in MN compared with MA or IA. M2 macrophages, defined as CD68+ HLA-DR- CD163+ cells, increased in the deciduae of MA and IA compared with EM. However, this increase was not observed in the deciduae of MN. CONCLUSION: Our findings of phenotypic characters of decidual macrophages in MN provide additional evidence that M2 polarization is favorable for the maintenance of early stages of pregnancy.

  Feb. 2018, American journal of reproductive immunology (New York, N.Y. : 1989), 79(2) (2), English, International magazine

  [Refereed]

  Scientific journal


• インフルエンザ

  Deguchi Masashi, 山田秀人

  2018, 産婦人科感染症マニュアル, 263 - 270, Japanese

  [Refereed]

  Scientific journal


• Pulmonary Hypoplasia Caused by Fetal Ascites in Congenital Cytomegalovirus Infection Despite Fetal Therapy

  Kazumichi Fujioka, Ichiro Morioka, Kosuke Nishida, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Kazumoto Iijima, Hideto Yamada

  Nov. 2017, FRONTIERS IN PEDIATRICS, 5, 241, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Universal Screening With Use of Immunoglobulin G Avidity for Congenital Cytomegalovirus Infection.

  Kenji Tanimura, Shinya Tairaku, Ichiro Morioka, Kana Ozaki, Satoshi Nagamata, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Toshio Minematsu, Hideto Yamada

  Background: The aim of this prospective cohort study was to evaluate the efficacy of maternal screening for congenital cytomegalovirus infection (CCI) using cytomegalovirus (CMV) immunoglobulin G (IgG) and the IgG avidity index (AI). Methods: Pregnant women underwent screening of CMV IgG and AI measurements. IgG-negative women underwent remeasurement of IgG after educational intervention. Women with an AI ≤45% received further examinations, including measurement of CMV IgM. All newborns received polymerase chain reaction analyses of the urine, and CCI was diagnosed by the detection of CMV-DNA in the urine. Primary infection was defined as an AI <35% and/or positive IgM (>1.20 index). Serum samples from women with an AI >45% were stored, and the IgM levels were measured after delivery. The efficacy of AI and IgM for CCI screening was compared. Results: A total of 1562 (71.2%) women tested positive for IgG. In this study, 10 newborns with CCI were detected. The presence of infection in 3 newborns from mothers with primary infection was predicted by screening of IgG and AI <35%. However, infection in 7 newborns from women with nonprimary infection could not be predicted by screening of CMV IgG, AI <35%, or IgM. The application of an AI <35% for CCI screening yielded 22.2% sensitivity, 95.0% specificity, 2.5% positive predictive value, and 99.5% negative predictive value and was similar to that of IgM (11.1% sensitivity, 93.2% specificity, 0.9% positive predictive value, and 92.7% negative predictive value). Conclusions: Maternal screening using CMV IgG and AI can identify pregnancies with CCI from primary infection, but overlooks a number of those from nonprimary infection.

  Oct. 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 65(10) (10), 1652 - 1658, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【TORCH症候群-母子感染における問題点】 先天性トキソプラズマ症の予防、診断と治療

  Deguchi Masashi, Tanimura Kenji

  日本医事新報社, Sep. 2017, 日本医事新報, (4872号) (4872号), 40 - 47, Japanese

  [Invited]

  Scientific journal


• 【TORCH症候群-母子感染における問題点】 先天性サイトメガロウイルス感染症の予防、診断と治療

  Tanimura Kenji, Deguchi Masashi

  日本医事新報社, Sep. 2017, 日本医事新報, (4872号) (4872号), 33 - 39, Japanese

  [Invited]

  Scientific journal


• 妊娠中にネフローゼ症候群を発症し、ステロイドおよび血漿交換にて完全寛解に至った一例

  小嶋 真理子, 後藤 俊介, 泉 博子, 内田 明子, 出口 雅士, 藤井 秀毅, 山田 秀人, 西 慎一

  (一社)日本腎臓学会, Sep. 2017, 日本腎臓学会誌, 59(6) (6), 717 - 717, Japanese


• 妊娠中の腎機能悪化を契機に発見された高Ca血症の一例

  泉 博子, 藤井 秀毅, 内山 美穂子, 出口 雅士, 山田 秀人, 西 愼一

  (一社)日本腎臓学会, Sep. 2017, 日本腎臓学会誌, 59(6) (6), 874 - 874, Japanese


• Factors associated with adverse pregnancy outcomes in women with antiphospholipid syndrome: A multicenter study.

  Masashi Deguchi, Hideto Yamada, Mayumi Sugiura-Ogasawara, Mamoru Morikawa, Daisuke Fujita, Akinori Miki, Shintaro Makino, Atsuko Murashima

  Aug. 2017, Journal of reproductive immunology, 122, 21 - 27, English, International magazine

  [Refereed]

  Scientific journal


• 【産婦人科領域における難病を考える-新たに成立した難病法の視点から】 [指定難病疾患] 抗リン脂質抗体症候群

  Deguchi Masashi, Tanimura Kenji, Yamada Hideto

  診断と治療社, Jul. 2017, 産科と婦人科, 84(7号) (7号), 804 - 809, Japanese

  [Invited]

  Scientific journal


• 先天性CMV感染児の出生体重と神経学的予後に関する検討

  西田 浩輔, 森岡 一朗, 大山 正平, 福嶋 祥代, 山名 啓司, 黒川 大輔, 岩谷 壮太, 藤岡 一路, 飯島 一誠, 出口 雅士, 谷村 憲司, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2017, 日本周産期・新生児医学会雑誌, 53(2) (2), 482 - 482, Japanese


• Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling.

  Qianlan Fan, Yuan Cheng, Hsun-Ming Chang, Masashi Deguchi, Aaron J Hsueh, Peter C K Leung

  Apr. 2017, Oncotarget, 8(16) (16), 27166 - 27176, English, International magazine

  [Refereed]

  Scientific journal


• 持続血糖モニターを用いた妊娠糖尿病患者における分娩中の血糖動態についての検討

  黒飛 友里, 村前 直和, 岡田 裕子, 山田 倫子, 中村 友昭, 福岡 秀規, 廣田 勇士, 坂口 一彦, 谷村 憲司, 森實 真由美, 出口 雅士, 山田 秀人, 小川 渉

  (一社)日本糖尿病学会, Apr. 2017, 糖尿病, 60(Suppl.1) (Suppl.1), S - 429, Japanese


• Natural killer cell activity in women with recurrent miscarriage: Etiology and pregnancy outcome.

  Yasuhiko Ebina, Yukari Nishino, Masashi Deguchi, Yoko Maesawa, Yuki Nakashima, Hideto Yamada

  Apr. 2017, Journal of reproductive immunology, 120, 42 - 47, English, International magazine

  [Refereed]

  Scientific journal


• Prediction of Congenital Cytomegalovirus Infection in High-Risk Pregnant Women.

  Kenji Tanimura, Shinya Tairaku, Yasuhiko Ebina, Ichiro Morioka, Satoshi Nagamata, Kana Deguchi, Mayumi Morizane, Masashi Deguchi, Toshio Minematsu, Hideto Yamada

  Jan. 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 64(2) (2), 159 - 165, English, International magazine

  [Refereed]

  Scientific journal


• 【周産期医学必修知識第8版】 産科編 抗リン脂質抗体検査

  Deguchi Masashi, Tanimura Kenji, 山田秀人

  Dec. 2016, 周産期医学, 46(増刊) (増刊), 114 - 117, Japanese

  [Invited]

  Scientific journal


• 【産婦人科感染症の最前線】 母子に影響を与える感染症 トキソプラズマ感染症

  山田秀人, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, Ebina Yasuhiko

  金原出版, Dec. 2016, 産婦人科の実際, 65(13号) (13号), 1719 - 1724, Japanese

  [Invited]

  Scientific journal


• インスリン使用/非使用GDM症例におけるインスリン分泌能・感受性指標の比較

  平野 靖子, 村前 直和, 高橋 陸, 山田 倫子, 中村 友昭, 福岡 秀規, 岡田 裕子, 廣田 勇士, 坂口 一彦, 谷村 憲司, 森實 真由美, 出口 雅士, 山田 秀人, 小川 渉

  (一社)日本糖尿病・妊娠学会, Oct. 2016, 糖尿病と妊娠, 16(3) (3), S - 66, Japanese


• Risk factors for postpartum glucose intolerance in women with gestational diabetes mellitus.

  Nobue Kojima, Kenji Tanimura, Masashi Deguchi, Mayumi Morizane, Yushi Hirota, Wataru Ogawa, Hideto Yamada

  OBJECTIVES: To determine the risk factors for glucose intolerance (GI) during the postpartum period in women with gestational diabetes mellitus (GDM). METHODS: This prospective cohort study included 72 Japanese women with GDM who underwent 75 g oral glucose tolerance tests (OGTT) at 12 weeks after delivery. These women were divided into the GI group and the normal group based on postpartum OGTT. Risk factors for GI, including levels of blood glucose (BG), area under the curve (AUC) of glucose, AUC insulin, HbA1c, homeostasis model assessment-insulin resistance (HOMA-IR), HOMA-β, insulinogenic index (II) and the oral disposition index (DI) in antepartum OGTT, were analyzed by logistic regression analyses. RESULTS: Of the 72 women, 60 (83.3%) were normal and 12 (16.7%) had GI. By univariate logistic regression analyses, fasting BG, AUC glucose, HOMA-β, II and oral DI were selected as risk factors for GI. Multivariate logistic regression analysis revealed that the level of II in antepartum OGTT was a significant factor that predicted GI after delivery (odds ratio, 0.008; 95% CI, 0.0001-0.9; p < 0.05). CONCLUSIONS: II measured by OGTT during pregnancy might be a useful predictor of GI within the early postpartum period in women with GDM.

  Oct. 2016, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 32(10) (10), 803 - 806, English, International magazine

  [Refereed]

  Scientific journal


• Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage.

  Yasuhiko Ebina, Shigeki Shimada, Masashi Deguchi, Yoko Maesawa, Norifumi Iijima, Hideto Yamada

  PROBLEM: The aim of this prospective study was to evaluate phenotypic differences of helper T (Th), cytotoxic T (Tc), and regulatory T (Treg) cells in the deciduae of missed miscarriage with a normal chromosome karyotype of a fetus (MN) and missed miscarriage with an abnormal chromosome karyotype of a fetus (MA). METHODS OF STUDY: The decidua of 19 MN and 28 MA was obtained. Additionally, the decidua of 15 induced abortion (IA) and the endometrium of 19 non-pregnant women (EM) were obtained. IFN-γ(+) , IL-17(+) , CD25(high) Foxp3(+) cells in CD4(+) (Th) cells, and IFN-γ(+) cells in CD8(+) (Tc) cells were evaluated by flow cytometry. RESULTS: The percentages of IFN-γ(+) Tc and CD4(+) CD25(high) Foxp3(+) (Treg) cells in MN were significantly increased as compared with MA and IA. The percentage of IFN-γ(+) Th in MN was increased as compared with IA. CONCLUSION: Activation of IFN-γ(+) Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN.

  Sep. 2016, American journal of reproductive immunology (New York, N.Y. : 1989), 76(3) (3), 199 - 204, English, International magazine

  [Refereed]

  Scientific journal


• Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss.

  Nanae Shinozaki, Yasuhiko Ebina, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Hideto Yamada

  This prospective study aimed to evaluate pregnancy outcome and complications in women with recurrent pregnancy loss (RPL) and protein S (PS) deficiency, who received low dose aspirin (LDA) or LDA plus heparin (LDA/H) therapies. Clinical characteristics, pregnancy outcome and complications of 38 women with two or more RPL and <60% of plasma free PS antigen were compared among three groups: antiphospholipid antibody (aPL)-negative women who received LDA (group A), aPL-negative women who received LDA/H (group B) and aPL-positive women who received LDA/H (group C). Gestational weeks (GW) at delivery in group C (median 32 GW) were earlier than 40 GW in group A and 38.5 GW in group B (p < 0.05). The birth weight in group C (median 1794 g) was less than 2855 g in group B (p < 0.05). The incidences of fetal growth restriction (37.5%), pregnancy-induced hypertension (37.5%), and preterm delivery (62.5%) in group C were higher than those (4.5%, 0%, and 4.5%, respectively) in group B (p<0.05). Women with RPL, PS deficiency, and positive aPL had high risks for adverse pregnancy outcome and complications, even when they received LDA/H therapy. Among women with RPL, PS, and negative aPL, there was no difference in these risks between LDA alone and LDA/H therapies.

  Aug. 2016, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 32(8) (8), 672 - 674, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 切迫早産入院管理の結果、妊娠29週未満で早産となった児の予後に関連する因子の検討

  宇治田直也, Tanimura Kenji, 平久進也, Maesawa Yoko, 森實真由美, Deguchi Masashi, Morioka Ichiro, 山田秀人

  Objective: We aimed to evaluate prognostic factors of outcome in neonates born at less than 29 weeks of gestation (GW) because of threatened premature labor. Patients and Methods: This was a retrospective study including 43 neonates who were born in our hospital between 2005 and 2014. These neonates were divided into two groups according to the outcome: good (healthy) and poor (handicapped or dead). We examined the following factors: GW at delivery, the presence of rupture of the membranes, maximum maternal leukocyte count 15000/μl and serum CRP level 2.0 mg/dl, highest maternal body temperature 37.5 degrees, maternal steroid administration, male sex, standard deviation of birthweight, and stage of chorioamnionitis grade 2. The prognostic factors for poor outcome were determined by uni- and multivariate logistic regression analyses. Results: Logistic regression analyses showed that GW at delivery was an independent prognostic factor of outcome of neonates (OR, 0.5; 95% CI, 0.3-0.9; p=0.03). Conclusions: This study suggests that the prognosis of neonates who are born at less than 29 GW because of threatened premature labor is associated with earlier GW at delivery. [Adv Obstet Gynecol, 68(2) : 69-74, 2016 (H28.5)]

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2016, 産婦人科の進歩, 68(2号) (2号), 69 - 74, Japanese

  [Refereed]

  Scientific journal


• Klippel-Trenaunay-Weber症候群合併妊娠の1例

  奥幸樹, Tanimura Kenji, 平久進也, Maesawa Yoko, 森實真由美, 森本規之, Deguchi Masashi, 山田秀人

  Klippel-Trenaunay-Weber syndrome (KTWS) is a rare disorder characterized by extensive cutaneous vascular malformation, venous varicosities, hemangiomas, and hypertrophy of soft or bony tissue. We herein report a case of a pregnant woman complicated with KTWS. A 23-year-old woman (gravida 1, para 0) underwent anticoagulation therapy with low-dose aspirin and unfractionated heparin from the first trimester because of the presence of hemangiomas. We assessed the location of the hemangiomas by pelvic and spinal magnetic resonance imaging (MRI) at gestational age (GA) of 27 and 35 weeks. A cesarean delivery with spinal anesthesia was supposed to be done based on the initial assessment of hemangiomas at GA of 27 weeks. However, MRI at GA at 35 weeks revealed hemangiomas developed newly around the lumbar. We therefore performed a cesarean delivery under general anesthesia at GA at 37 weeks. During the operation, we examined the location of the hemangiomas in abdominal wall by transabdominal ultrasound and avoided injuring the hemangiomas. The patient delivered a 2518g healthy female infant and received anticoagulation therapy for six weeks after delivery, preventing thrombosis and embolism. In conclusion, anticoagulation therapy and decision of style and method of parturient based on the assessment of the location of hemangiomas by MRI, ultrasonography and bronchoscopy may enable safer perinatal management for pregnancies complicated by KTWS. [Adv Obstet Gynecol, 68 (2) : 93-98, 2016 (H28.5)]

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2016, 産婦人科の進歩, 68(2号) (2号), 93 - 98, Japanese

  [Refereed]


• 先天性サイトメガロウイルス感染症児における生後早期の頭部MRI所見

  西田 浩輔, 森岡 一朗, 出口 雅士, 谷村 憲司, 平久 進也, 蝦名 康彦, 山田 秀人

  (公社)日本産科婦人科学会, Feb. 2016, 日本産科婦人科学会雑誌, 68(2) (2), 781 - 781, Japanese


• Neurological outcomes in symptomatic congenital cytomegalovirus-infected infants after introduction of newborn urine screening and antiviral treatment.

  Kosuke Nishida, Ichiro Morioka, Yuji Nakamachi, Yoko Kobayashi, Takamitsu Imanishi, Seiji Kawano, Sota Iwatani, Tsubasa Koda, Masashi Deguchi, Kenji Tanimura, Daisuke Yamashita, Ken-Ichi Nibu, Toru Funakoshi, Masanobu Ohashi, Naoki Inoue, Kazumoto Iijima, Hideto Yamada

  BACKGROUND: Newborn screening for urinary cytomegalovirus (CMV) and early introduction of antiviral treatment are expected to improve neurological outcomes in symptomatic congenital CMV-infected infants. This cohort study prospectively evaluated neurological outcomes in symptomatic congenital CMV-infected infants following the introduction of hospital-based newborn urinary CMV screening and antiviral treatment. SUBJECTS/METHODS: Following institutional review board approval and written informed consent from their parents, newborns were prospectively screened from 2009 to 2014 for urinary CMV-DNA by PCR within 1 week after birth at Kobe University Hospital and affiliated hospitals. CMV-positive newborns were further examined at Kobe University Hospital, and those diagnosed as symptomatic were treated with valganciclovir for 6 weeks plus immunoglobulin. Clinical neurological outcomes were evaluated at age ⩾12 months and categorized by the presence and severity of neurologic sequelae. RESULTS: Urine samples of 6348 newborns were screened, with 32 (0.50%) positive for CMV. Of these, 16 were diagnosed with symptomatic infection and 12 received antiviral treatment. Four infants developed severe impairment (33%), three developed mild impairment (25%), and five developed normally (42%). CONCLUSIONS: This is the first Japanese report of neurological assessments in infants with symptomatic congenital CMV infection who received early diagnosis and antiviral treatment. Urinary screening, resulting in early diagnosis and treatment, may yield better neurological outcomes in symptomatic congenital CMV-infected infants.

  Feb. 2016, Brain & development, 38(2) (2), 209 - 16, English, International magazine

  [Refereed]

  Scientific journal


• Extremely preterm infants small for gestational age are at risk for motor impairment at 3 years corrected age

  Takeshi Kato, Tsurue Mandai, Sota Iwatani, Tsubasa Koda, Miwako Nagasaka, Kaori Fujita, Daisuke Kurokawa, Keiji Yamana, Kosuke Nishida, Mariko Taniguchi-Ikeda, Kenji Tanimura, Masashi Deguchi, Hideto Yamada, Kazumoto Iijima, Ichiro Morioka

  Feb. 2016, BRAIN & DEVELOPMENT, 38(2) (2), 188 - 195, English

  [Refereed]

  Scientific journal


• 6学会合同シンポジウム4 β2-グリコプロテインI/HLA class II複合体は抗リン脂質抗体症候群の標的抗原である

  谷村 憲司, 出口 雅士, 蝦名 康彦, 渥美 達也, 山田 秀人, 荒瀬 尚

    β2-glycoprotein I（β2GPI）は抗リン脂質抗体（aPL）の主要抗原であり，また，抗リン脂質抗体症候群（APS）の疾患感受性にHLA class II（HLA-II）遺伝子多型が関与する．しかし，HLA-II分子が疾患感受性を制御する機序については不明である．

    最近，MHC-IIがペプチドへの分解を免れたmisfolded蛋白を提示し，B細胞を直接活性化する機構が報告された．今回，この新規抗原提示機構とAPSの病因・病態との関連を解析した．

    初めに，β2GPIとHLA-IIを共発現させた293T細胞を用いた免疫沈降により，full-lengthのβ2GPIとHLA-IIが複合体を形成していることを確認した．さらに，ヒトaPLモノクローナル抗体とAPS患者血清中の自己抗体がβ2GPIとAPS疾患感受性アレルであるHLA-II（HLA-DR7, DR4）の複合体に対して高い結合親和性を有することが分かった．また，流産組織を用いた蛍光免疫染色により，APS患者の脱落膜血管内皮細胞にβ2GPIとHLA-DRが共発現していることを明らかにした．APS患者120名の血清中のβ2GPI/HLA-DR7複合体に対する自己抗体の抗体価をFlow cytometry法で測定したところ，APS患者の約80％で陽性で，さらに，抗カルジオリピン抗体や抗β2GPI抗体が陰性であるAPS患者の約半数で本自己抗体が陽性となった．また，ヒトaPLモノクローナル抗体はβ2GPI/HLA-DR7発現細胞に特異的に補体依存性細胞障害を誘導した．

    APS患者血清中に，misfolded β2GPI/HLA-II複合体に対する自己抗体が存在することを初めて明らかにした．この自己抗体によって血管内皮細胞が障害され，血栓症や流産を惹起さるというAPSの新しい病態が示された．

  日本臨床免疫学会, 2016, 日本臨床免疫学会会誌, 39(4) (4), 306 - 306, Japanese


• 電撃性紫斑病(重症型先天性プロテインC欠損症)の出生前診断を行った2例

  野村晃子, 平久進也, Tanimura Kenji, Deguchi Masashi, 山田秀人, 池田真理子, Toda Tatsushi

  Dec. 2015, 兵庫県母性衛生学会雑誌, (24号) (24号), 39 - 42, Japanese

  [Refereed]


• 【伝染性紅斑を見直す】 母子感染の実態 全国産科施設を対象とした実態調査

  Ebina Yasuhiko, 平久進也, Morioka Ichiro, Deguchi Masashi, Morizane Mayumi, Yamada Hideto

  金原出版, Nov. 2015, 小児科, 56(12号) (12号), 1867 - 1873, Japanese

  Scientific journal


• Clinical features of obstetrical antiphospholipid syndrome in Japanese population - A multicenter study

  Deguchi Masashi, Yamada Hideto, Fujita Daisuke, Sugiura Mayumi, Morikawa Mamoru, Miki Akinori, Makino Shintaro, Murashima Atsuko

  Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 134

  [Refereed]


• The IgG avidity value for the prediction of Toxoplasma gondii infection in the amniotic fluid.

  Kenji Tanimura, Akira Nishikawa, Shinya Tairaku, Nanae Shinozaki, Masashi Deguchi, Mayumi Morizane, Yasuhiko Ebina, Ichiro Morioka, Hideto Yamada

  Primary Toxoplasma gondii (T. gondii) infection during pregnancy may lead to congenital toxoplasmosis. Maternal screening using T. gondii IgG avidity measurement and multiplex nested PCR was performed. The aim of this prospective cohort study was to determine a cut-off value of IgG avidity index (AI) for the prediction of the presence of T. gondii DNA in the amniotic fluid. One hundred thirty-nine women with positive or equivocal tests for IgM underwent both serum IgG avidity measurement and PCR analysis for the amniotic fluid. Nine had positive PCR results, and three of them were diagnosed as having congenital infection. A cut-off value of IgG AI was determined using receiver operating characteristic analysis. IgG AI (mean 13%) in women with positive PCR results was significantly lower than that (39%) in women with negative results. A cut-off value of <25% IgG AI yields the best results with 77.8% sensitivity and 81.5% specificity for the presence of T. gondii DNA in the amniotic fluid. None of women with IgG AI of ≥30% had a positive PCR result or congenital infection. This study firstly demonstrated that a cut-off value of 25-30% IgG AI might be useful for the prediction of the presence of T. gondii DNA in the amniotic fluid and congenital infection.

  Sep. 2015, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(9) (9), 668 - 71, English, International magazine

  [Refereed]

  Scientific journal


• Low levels of plasma protein S, protein C and coagulation factor XII during early pregnancy and adverse pregnancy outcome.

  Yasuhiko Ebina, Masahiro Ieko, Sumiyoshi Naito, Gen Kobashi, Masashi Deguchi, Hisanori Minakami, Tatsuya Atsumi, Hideto Yamada

  It was the study objective to evaluate whether low levels of plasma protein S (PS) activity, free PS, protein C (PC) activity and coagulation factor XII (FXII) during early pregnancy are related to adverse pregnancy outcomes. Peripheral blood samples were obtained at 8-14 gestational weeks (GW) from a consecutive series of 1,220 women. The levels of plasma PS activity, free PS, PC activity, and FXII were measured. Cut-off values were defined as < 1st, < 5th, and < 10th percentiles of values obtained from 933 women whose pregnancies ended in normal deliveries without complications. PS activity of < 10th percentile yielded risks of pregnancy-induced hypertension (PIH) and severe PIH, while free PS level of < 5th percentile yielded a risk of pre-eclampsia. FXII level of < 1st percentile yielded a risk of premature delivery (PD) at < 34 GW. None was associated with PD at < 37 GW, fetal growth restriction or fetal loss. A multivariate analysis demonstrated that PS activity of < 10th percentile (odds ratio 5.9, 95 % confidence interval 1.7-18.1) and body mass index (BMI) ≥ 25 kg/m² (4.3, 1.1-13.3) were independent risk factors for severe PIH. Similarly, free PS level of < 5th percentile (4.4, 1.0-14.3) and BMI ≥ 25 kg/m² (4.0, 1.3-10.9) were independent risk factors for pre-eclampsia. In conclusion, women with low levels of plasma PS activity and free PS during early pregnancy might have increased risks of PIH, severe PIH or pre-eclampsia. Women with low FXII level might have an increased risk of PD at < 34 GW.

  20150416, Jul. 2015, Thrombosis and haemostasis, 114(1) (1), 65 - 9, English, International magazine

  [Refereed]


• 【母子感染Update】 妊娠とサイトメガロウイルス CMV母子感染対策の現状と問題点

  Deguchi Masashi, Yamada Hideto

  Jun. 2015, 医学のあゆみ, 253(13号) (13号), 1215 - 1219, Japanese

  Scientific journal


• 【Stop the 流産】 難治性不育症に対する高用量免疫グロブリン療法

  Deguchi Masashi, Maesawa Yoko, 武田真光, Yamada Hideto

  金原出版, Jun. 2015, 産婦人科の実際, 64(6号) (6号), 797 - 803, Japanese

  Scientific journal


• Medium-dose intravenous immunoglobulin therapy for women with six or more recurrent miscarriages.

  Hideto Yamada, Masashi Deguchi, Yoko Maesawa, Yuki Nakajima, Yukari Nishino, Kenji Tanimura, Yasuhiko Ebina

  This study aimed to evaluate changes in natural killer (NK) cell activity and the percentage of monocytes in women with recurrent miscarriage who received medium-dose intravenous immunoglobulin (IVIg) therapy. Fourteen women with a history of six or more recurrent miscarriages of unexplained etiology received 60-g IVIg therapy (20 g daily, for three days) during early gestation. NK cell activity in the peripheral blood decreased to 12% one week after therapy compared with before therapy (median, 22%, P < 0.001) and the percentage of monocytes increased from 5.2% to 7.5% (P < 0.005). Four pregnancies ended in live births of healthy neonates, whereas the other ten pregnancies ended in miscarriages. Excluding one miscarriage with a chromosomal abnormality, the live birth rate was 30.8% (4/13). The rate of reduction of NK cell activity in the success group (-58.8%) tended to be greater than that in the failure group (-14.8%, P = 0.057).

  Jun. 2015, Journal of reproductive immunology, 109, 48 - 51, English, International magazine

  [Refereed]

  Scientific journal


• Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP.

  Yuan Cheng, Yi Feng, Lina Jansson, Yorino Sato, Masashi Deguchi, Kazuhiro Kawamura, Aaron J Hsueh

  Hippo signaling pathway consists of conserved serine/threonine kinases to maintain optimal organ sizes. Studies have demonstrated that fragmentation of murine ovaries increases actin polymerization and disrupts Hippo signaling, leading to nuclear translocation of Hippo signaling effector Yes-associated protein (YAP) in ovarian follicles and follicle growth. For patients with polycystic ovarian syndrome showing follicle arrest, ovarian wedge resection and laser drilling promote follicle growth. Because these damaging procedures likely involve actin polymerization, we tested whether actin polymerization-promoting drugs could promote YAP translocation and stimulate follicle growth. Treatment of murine ovaries with μM Jasplakinolide (JASP), an actin polymerization-promoting cyclic peptide, or sphingosine-1-phosphate (S1P), a follicular fluid constituent known to promote actin polymerization, increased the conversion of globular actin to the filamentous form, followed by increased nuclear YAP and expression of downstream connective tissue growth factor (CCN2). After short-term treatments with JASP or S1P, in vitro cultured and in vivo grafted ovaries showed follicle growth. Furthermore, induction of constitutively active YAP in ovarian grafts of transgenic mice enhanced follicle development, whereas treatment of human ovarian cortices with JASP or S1P increased CCN2 expression. Thus, JASP and S1P stimulate follicle growth and are potential therapeutic agents for treating polycystic ovarian syndrome and other ovarian disorders.

  Jun. 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(6) (6), 2423 - 30, English, International magazine

  [Refereed]

  Scientific journal


• 妊娠中のサイトメガロウイルス検査とその解釈

  Deguchi Masashi

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2015, 産婦人科の進歩, 67(2号) (2号), 140 - 144, Japanese

  [Invited]

  Scientific journal


• Rapid increase in the serum Cytomegalovirus IgG avidity index in women with a congenitally infected fetus.

  Yasuhiko Ebina, Toshio Minematsu, Ichiro Morioka, Masashi Deguchi, Shinya Tairaku, Kenji Tanimura, Ayako Sonoyama, Satoshi Nagamata, Mayumi Morizane, Hideto Yamada

  BACKGROUND: Human Cytomegalovirus (CMV) is the virus most frequently responsible for severe diseases of the fetus and newborn. The reported intrauterine transmission rate of CMV following primary maternal infection is approximately 40%. Invasive techniques are needed for the prenatal diagnosis of congenital CMV infection. OBJECTIVES: The aim of this study was to evaluate whether the rapidity of change in the CMV IgG avidity index (AI) is associated with the presence of congenital CMV infection among mothers with suspected primary CMV infection. STUDY DESIGN: The serum CMV IgG AI was repeatedly measured in 17 pregnant women with positive or borderline test results for CMV IgM together with an initial IgG AI value of <40%. Their neonates underwent polymerase chain reaction analyses for the presence of CMV DNA in the urine. The rapidity of change in the IgG AI per 4 weeks was defined as the ΔAI (%). The ΔAI of women with congenital CMV infection was compared with that of women with no infection. RESULTS: The ΔAI of nine mothers with congenital CMV infection (median,15.7%; range,7.8-42.8%) was significantly higher than that of eight mothers with no infection (median, 6.5%, range, 2.0-8.8%; p<0.001). The incidences of congenital CMV infection were 100.0%, 16.7%, and 0.0% among mothers with a ΔAI of >10, 5-10, and <5%, respectively. CONCLUSIONS: Measurement of the ΔAI in pregnant women might be useful for estimating the risk of mother-to-neonate CMV transmission.

  May 2015, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 66, 44 - 7, English, International magazine

  [Refereed]


• History of biochemical pregnancy was associated with the subsequent reproductive failure among women with recurrent spontaneous abortion.

  Yoko Maesawa, Hideto Yamada, Masashi Deguchi, Yasuhiko Ebina

  The aim of this study was to evaluate whether the presence of history of biochemical pregnancy (BP) was associated with clinical characteristics and the subsequent pregnancy outcome among women with recurrent spontaneous abortion (RSA). One-hundred and seventy-five RSA women with two or more clinical pregnancy losses were enrolled. The clinical characteristics were compared between 164 women with history of 0-1 BP (Group A) and 11 women with two or more BP (Group B). The frequency of previous pregnancy loss and history of in vitro fertilization and embryo transfer in Group B was higher than that in Group A; while frequency of secondary RSA in Group B was lower than Group A. The subsequent pregnancy outcome was assessed prospectively; and live-birth rate in Group A (72.9%) was higher (p < 0.05) than that in Group B (41.7%). The incidence of reproductive failure (58.3%, p < 0.05) and spontaneous abortion with normal chromosome (25.0%, p = 0.050) in Group B was higher than those (27.1 and 5.9%, respectively) in Group A. RSA women with two or more BP had higher risk of reproductive failure and spontaneous abortion with normal chromosome together with lower chance of live-birth. The results of the present study involve important information and are helpful for clinical practitioners.

  Apr. 2015, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(4) (4), 306 - 8, English, International magazine

  [Refereed]

  Scientific journal


• Prediction of adherent placenta in pregnancy with placenta previa using ultrasonography and magnetic resonance imaging.

  Kenji Tanimura, Yui Yamasaki, Yasuhiko Ebina, Masashi Deguchi, Yoshiko Ueno, Kazuhiro Kitajima, Hideto Yamada

  OBJECTIVE: Adherent placenta is a life-threatening condition in pregnancy, and is often complicated by placenta previa. The aim of this prospective study was to determine prenatal imaging findings that predict the presence of adherent placenta in pregnancies with placenta previa. STUDY DESIGN: The study included 58 consecutive pregnant women with placenta previa who underwent both ultrasonography and magnetic resonance imaging prenatally. Ultrasonographic findings of anterior placental location, grade 2 or higher placental lacunae (PL≥G2), loss of retroplacental hypoechoic clear zone (LCZ) and the presence of turbulent blood flow in the arteries were evaluated, in addition to MRI findings. Forty-three women underwent cesarean section alone; 15 women with adherent placenta underwent cesarean section followed by hysterectomy with pathological examination. To determine imaging findings that predict adherent placenta, univariate and multivariate logistic regression analyses were performed. RESULTS: Univariate logistic regression analyses demonstrated that anterior placental location, PL≥G2, LCZ, and MRI were associated with the presence of adherent placenta. Multivariate analyses revealed that LCZ (p<0.01, odds ratio 15.6, 95%CI 2.1-114.6) was a single significant predictor of adherent placenta in women with placenta previa. CONCLUSION: This prospective study demonstrated for the first time that US findings, especially LCZ, might be useful for identifying patients at high risk for adherent placenta among pregnant women with placenta previa.

  Apr. 2015, European journal of obstetrics, gynecology, and reproductive biology, 187, 41 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Human recombinant H2 relaxin induces AKT and GSK3β phosphorylation and HTR-8/SVneo cell proliferation.

  Yoni Astuti, Koji Nakabayashi, Masashi Deguchi, Yasuhiko Ebina, Hideto Yamada

  Relaxin is essential for trophoblast development during pregnancy. Evidence shows that relaxin increases trophoblast cell migration capacity. Here, we show the effect of relaxin on protein kinase B (AKT) activation and glycogen synthase kinase 3-beta (GSK3β) inactivation as well as on the proliferation of HTR-8/SVneo cells, a model of human extravillous trophoblast (EVT). HTR-8/SVneo cells were treated with different doses of human recombinant (rH2) relaxin in serum-deprived conditions and treated for increasing time with 1 ng/mL of rH2 relaxin. Western blot analysis was performed to detect pAKT, AKT, pGSK3β, GSK3β, and actin expression. Proliferation of HTR-8/SVneo cells was analyzed by MTS assay. rH2 relaxin treatment increased the ratio of pAKT/AKT, pGSK3β/GSK3β, and proliferation in HTR-8/SVneo cells. Furthermore, AKT and GSK3β activation by rH2 relaxin was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor. This study suggests that rH2 relaxin induces AKT and GSK3β phosphorylation as well as proliferation in HTR-8/SVneo cells.

  1, Mar. 2015, The Kobe journal of medical sciences, 61(1) (1), E1-8 - 8, English, Domestic magazine

  [Refereed]


• Nationwide survey of mother-to-child infections in Japan.

  Hideto Yamada, Shinya Tairaku, Ichiro Morioka, Ayako Sonoyama, Kenji Tanimura, Masashi Deguchi, Satoshi Nagamata, Yasuhiko Ebina

  OBJECTIVES: The aim of this survey study was to evaluate a state of mother-to-child infections in Japan. METHODS: A nationwide survey on 2714 obstetric facilities where regular maternity checkups were carried out was conducted. A primary questionnaire assessed numbers of pregnancies including induced abortion, spontaneous abortion, still-birth as well as live-birth, which were affected by congenital infections of 6 pathogens during a year of 2011. The secondary questionnaire assessed clinical information, diagnostic modality, and the outcome for each case. The clinical features and diagnostic problems were evaluated. RESULTS: The high reply rates for the primary (73.7%) and the secondary questionnaire (100%) were achieved. The presence of congenital infections for 34 cases with cytomegalovirus (CMV), 1 with Toxoplasma gondii, 4 with rubella virus, 5 with Treponema pallidum, 8 with herpes simplex virus, and 69 with parvovirus B19 was confirmed after questionnaire assessment. The incidence of fetal demise among pregnancies with congenital parvovirus B19 infection was up to 71.0%. Eleven mothers with hydrops fetalis received prenatal fetal therapies involving fetal blood transfusion and immunoglobulin administration, whereas only three pregnancies (27.3%) ended in live-births. CONCLUSIONS: This survey study for the first time revealed the annual frequency of pregnancies with mother-to-child infections of 6 pathogens in Japan. The results involve important information and are helpful for clinical practitioners. The majority of neonates with congenital infection of CMV or T. gondii might be undiagnosed in obstetric facilities.

  Mar. 2015, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(3) (3), 161 - 4, English, International magazine

  [Refereed]

  Scientific journal


• 全新生児を対象とした尿サイトメガロウイルススクリーニングの臨床的有用性

  西田 浩輔, 森岡 一朗, 出口 雅士, 谷村 憲司, 平久 進也, 蝦名 康彦, 船越 徹, 大橋 正伸, 山田 秀人

  (公社)日本産科婦人科学会, Feb. 2015, 日本産科婦人科学会雑誌, 67(2) (2), 601 - 601, Japanese


• 症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果

  森岡 一朗, 西田 浩輔, 出口 雅士, 谷村 憲司, 平久 進也, 蝦名 康彦, 山田 秀人

  (公社)日本産科婦人科学会, Feb. 2015, 日本産科婦人科学会雑誌, 67(2) (2), 602 - 602, Japanese


• Fetal therapy for symptomatic congenital cytomegalovirus infection with immunoglobulin

  UENAKA Mizuki, TANIMURA Kenji, WASHIO Keiichi, TAIRAKU Shinya, SHINOZAKI Nanae, MORIZANE Mayumi, DEGUCHI Masashi, EBINA Yasuhiko, MORIOKA Ichiro, YAMADA Hideto

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2015, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 67(3) (3), 357 - 357, Japanese


• Viper bite during pregnancy: case report

  M. Nishimoto, Y. Miyahara, Y. Ebina, M. Deguchi, S. Matsuoka, H. Yamada

  2015, CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 42(2) (2), 243 - 245, English

  [Refereed]

  Scientific journal


• Role of diffusion weighted imaging and contrast-enhanced MRI in the evaluation of intrapelvic recurrence of gynecological malignant tumor.

  Kazuhiro Kitajima, Utaru Tanaka, Yoshiko Ueno, Tetsuo Maeda, Yuko Suenaga, Satoru Takahashi, Masashi Deguchi, Yoshiya Miyahara, Yasuhiko Ebina, Hideto Yamada, Masakatsu Tsurusaki, Yukihisa Tamaki, Kazuro Sugimura

  BACKGROUND AND PURPOSE: To investigate the diagnostic performance of diffusion-weighted imaging (DWI) and contrast-enhanced imaging in combination with T2-weighted imaging (T2WI) for magnetic resonance imaging (MRI) evaluation of intrapelvic recurrence of gynecological malignancies. MATERIALS AND METHODS: Sixty-two patients with suspected intrapelvic recurrence of gynecological malignancies underwent pelvic MRI including T2WI DWI, and contrast-enhanced imaging. Diagnostic performance for detection of local recurrence, pelvic lymph node and bone metastases, and peritoneal lesions was evaluated by consensus reading of two experienced radiologists using a 5-point scoring system, and compared among T2WI with unenhanced T1-weighted imaging (T1WI) (protocol A), a combination of protocol A and DWI (protocol B), and a combination of protocol B and contrast-enhanced imaging (protocol C). Final diagnoses were obtained by histopathological examinations, radiological imaging and clinical follow-up for at least 6 months. Receiver operating characteristic (ROC) analysis and McNemar test were employed for statistical analysis. RESULTS: Locally recurrent disease, lymph node recurrence, peritoneal dissemination and bone metastases were present in 48.4%, 29.0%, 16.1%, and 6.5% of the patients, respectively. The patient-based sensitivity, specificity, accuracy, and area under the ROC curve (AUC) for detection of intrapelvic recurrence were 55.0, 81.8, 64.5% and 0.753 for protocol A, 80.0, 77.3, 79.0% and 0.838 for protocol B, and 80.0, 90.9, 83.9% and 0.862 for protocol C, respectively. The sensitivity, accuracy, and AUC were significantly better for protocols B and C than for protocol A (p<0.001). There was no significant difference between protocols B and C. CONCLUSION: MRI using a combination of DWI and T2WI gives comparatively acceptable results for assessment of intrapelvic recurrence of gynecological malignancies.

  2015, PloS one, 10(1) (1), e0117411, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• サイトメガロウイルス妊娠管理マニュアル

  藤井 知行, 金山 尚裕, 川名 敬, 齋藤 滋, 鮫島 浩, 増崎 英明, 山田 秀人, 岡 明, 古谷野 伸, 森内 浩幸, 森岡 一朗, 吉川 哲史, 井上 直樹, 木村 宏, 錫谷 達夫, 峰松 俊夫, 小林 廉毅, 川名 尚, 小島 俊行, 鮫島 浩二, 谷村 憲司, 出口 雅士, 永松 健, 山口 暁, 厚生労働科学班研究成育疾患克服等次世代育成基盤研究事業, 成育疾患克服等総合研究事業, 母子感染の実態把握及び検査, 治療に関する

  (公社)日本産科婦人科学会, Dec. 2014, 日本産科婦人科学会雑誌, 66(12付録) (12付録), 1 - 15, English

  Scientific journal


• 【周産期感染症2014】 産科からみた周産期感染症 妊婦のサイトメガロウイルス感染症

  Deguchi Masashi, Yamada Hideto

  Nov. 2014, 周産期医学, 44(増刊) (増刊), 158 - 163, Japanese

  [Invited]

  Scientific journal


• The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study.

  Yasuhiko Ebina, Toshio Minematsu, Ayako Sonoyama, Ichiro Morioka, Naoki Inoue, Shinya Tairaku, Satoshi Nagamata, Kenji Tanimura, Mayumi Morizane, Masashi Deguchi, Hideto Yamada

  BACKGROUND: Cytomegalovirus (CMV) causes congenital infection with high mortality and morbidity rates in affected neonates. OBJECTIVES: To evaluate the maternal IgG avidity value for the prediction of congenital CMV infection. STUDY DESIGN: The serum IgG avidity in all mothers was measured, and the urine of their neonates was assessed for CMV DNA in a prospective cohort study. RESULTS: Of 759 women with a positive test for CMV IgG, 14 had congenital CMV infection. CMV IgG avidity indices in the congenital infection group (median 35.1%) were significantly lower than those in the non-congenital infection group (70.4%). A cutoff value of <40% IgG avidity index with 96.1% specificity and 64.3% sensitivity for congenital infection was determined by receiver operating characteristic curve analyses. The highest sensitivity (88.9%), 96.2% specificity, 27.6% positive predictive value, 99.8% negative predictive value, and 96.1% accuracy were found when IgG avidity was measured in <28 weeks of gestation. CONCLUSION: The IgG avidity measurement with a cutoff value of <40% IgG avidity index might be helpful in predicting congenital CMV infection, especially in <28 weeks of gestation.

  Nov. 2014, Journal of perinatal medicine, 42(6) (6), 755 - 9, English, International magazine

  [Refereed]

  Scientific journal


• 不育症と生化学的妊娠

  Maesawa Yoko, Deguchi Masashi, 蝦名 康彦, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 491, Japanese

  Research society


• 治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法

  Deguchi Masashi, Tanimura Kenji, 篠崎 奈々絵, 今福 仁美, Maesawa Yoko, 平久 進也, 葉 宜慧, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 492, Japanese

  Research society


• 原因不明の難治性習慣流産14例に対する60g免疫グロブリン療法

  葉 宜慧, Deguchi Masashi, 中島 由貴, 伊勢 由香里, Maesawa Yoko, 篠崎 奈々絵, 蝦名 康彦, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 492, Japanese

  Research society


• 妊娠により1型糖尿病性腎症の悪化をみとめ腎生検を施行した一例

  石田 理紗, 後藤 俊介, Nakai Kentaro, 河野 圭志, 藤井 秀毅, 石原 あゆみ, Deguchi Masashi, 原 重雄, 西 慎一

  (一社)日本腎臓学会, Aug. 2014, 日本腎臓学会誌, 56(6号) (6号), 692 - 692, Japanese


• Prophylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.

  Kenji Tanimura, Shinya Tairaku, Masashi Deguchi, Ayako Sonoyama, Mayumi Morizane, Yasuhiko Ebina, Ichiro Morioka, Hideto Yamada

  The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV antibody was injected intravenously at a dosage of 2.5-5.0 g/day for consecutive 3 days to mothers with primary CMV infection. Four pregnant women were enrolled. One pregnancy ended in no congenital infection, while two pregnancies ended in congenital CMV infection. The other one pregnancy was terminated. The mother-to-fetus CMV transmission rate was found to be high as 66.7% (2/3). This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.

  Jul. 2014, The Kobe journal of medical sciences, 60(2) (2), E25-9 - 9, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• In vitro fertilization-embryo transfer pregnancy was a risk factor for hemorrhagic shock in women with placental polyp.

  Yoshiya Miyahara, Natsuko Makihara, Yui Yamasaki, Yasuhiko Ebina, Masashi Deguchi, Hideto Yamada

  OBJECTIVE: The aim of this study was to determine the risk factors for hemorrhagic shock in women with placental polyp. MATERIALS AND METHODS: Twelve women (group A) developed hemorrhagic shock (shock index<1.5) and received uterine artery embolization (UAE). The other 25 women (group B) had shock index<1.5 and did not receive UAE. All women underwent transcervical resection (TCR). The risk factors for the development of hemorrhagic shock, including the age, conception mode, numbers of previous abortion, gestational weeks at termination of pregnancy (TOP), blood loss weights at TOP and at TCR, were analyzed. RESULTS: When compared with group B, group A had higher in vitro fertilization-embryo transfer (IVF-ET) pregnancy rate (58.3 versus 12.0%, p<0.01), number of previous abortion (median 1.58 versus 0.68, p<0.05), gestational weeks at TOP (median 36.5 versus 17.0 weeks, p<0.05), and blood loss weight at TOP (median 2151 versus 40 g, p<0.05). A logistic regression analysis reveled that IVF-ET (OR 41, 95% CI 1.3-1264) and blood loss weight at TOP (1.0025, 1.0006-1.0044) were independent risk factors for hemorrhagic shock. CONCLUSIONS: For the first time, IVF-ET pregnancy was found to be a risk factor for the development of hemorrhagic shock in women with placental polyp.

  Jul. 2014, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(7) (7), 502 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Fusion of PET and MRI for staging of uterine cervical cancer: comparison with contrast-enhanced F-18-FDG PET/CT and pelvic MRI

  Kazuhiro Kitajima, Yuko Suenaga, Yoshiko Ueno, Tomonori Kanda, Tetsuo Maeda, Masashi Deguchi, Yasuhiko Ebina, Hideto Yamada, Satoru Takahashi, Kazuro Sugimura

  Jul. 2014, CLINICAL IMAGING, 38(4) (4), 464 - 469, English

  [Refereed]

  Scientific journal


• Nationwide survey of maternal screening for mother-to-child infections in Japan.

  Hideto Yamada, Shinya Tairaku, Ichiro Morioka, Yasuhiko Ebina, Ayako Sonoyama, Kenji Tanimura, Masashi Deguchi, Satoshi Nagamata

  Mother-to-child infections cause congenital infection with disease and sequelae. To evaluate a state of maternal blood screening for mother-to-child infections in Japan, we for the first time conducted a nationwide survey on obstetric facilities where regular maternity checkups were carried out. A questionnaire assessment involved an annual number of deliveries, scale of facilities and a state of maternal blood screening for eight pathogens. A high rate (73.7%) of reply to the questionnaire was achieved from 1990 facilities, covering 75.1% of annual number of delivery in 2011. The performance rates of blood screening were more than 99% for rubella virus, Treponema pallidum, human immunodeficiency virus (HIV), human T cell leukemia virus type 1 (HTLV-1), hepatitis B virus, and hepatitis C virus, while the rate was found to be only 4.5% for cytomegalovirus (CMV), and 48.5% for Toxoplasma gondii with large differences in regions. Most of the facilities performed blood tests for rubella virus, Treponema pallidum, HIV, hepatitis B virus and hepatitis C virus once in early pregnancy, while approximately 28% of the facilities performed blood tests for HTLV-1 once during the 2nd or 3rd trimester. Most of the facilities used HA tests for Toxoplasma gondii, whereas there was a wide variation in antibody measurement methods for CMV. Generally, the obstetric facilities in Japan have performed maternal blood screening properly according to the current recommendations. The results of this survey involve important information and are helpful for clinical practitioners.

  May 2014, Congenital anomalies, 54(2) (2), 100 - 3, English, International magazine

  [Refereed]

  Scientific journal


• Management of Thromboembolism in Pregnant Women with Inherited Antithrombin

  YASUHIKO EBINA

  Apr. 2014, EXPERIMENTAL & CLINICAL CARDIOLOGY, 20(6) (6), 145 - 159, English

  [Refereed]

  Scientific journal


• 不育症患者における非妊娠時の末梢血NK細胞活性と妊娠帰結

  伊勢 由香里, Deguchi Masashi, 中島 由貴, 白川 得朗, Maesawa Yoko, 篠崎 奈々絵, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 691 - 691, Japanese

  Research society


• 治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法

  Deguchi Masashi, 宮原 義也, 谷村 憲司, 白川 得朗, 篠崎 奈々絵, Maesawa Yoko, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 587 - 587, Japanese

  Research society


• 原因不明かつ6回以上自然流産の既往のある治療抵抗性・難治性習慣流産14人に対する60g免疫グロブリン療法

  中島 由貴, Deguchi Masashi, 伊勢 由香里, 白川 得朗, Maesawa Yoko, 篠崎 奈々絵, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 586 - 586, Japanese

  Research society


• プロテインS低下不育症の妊娠帰結

  篠崎 奈々絵, Deguchi Masashi, 森上 聡子, Maesawa Yoko, 平久 進也, 松岡 正造, 蝦名 康彦, 森田 宏紀, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 584, Japanese

  Research society


• Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment.

  Kazuhiro Kawamura, Yuan Cheng, Nao Suzuki, Masashi Deguchi, Yorino Sato, Seido Takae, Chi-hong Ho, Nanami Kawamura, Midori Tamura, Shu Hashimoto, Yodo Sugishita, Yoshiharu Morimoto, Yoshihiko Hosoi, Nobuhito Yoshioka, Bunpei Ishizuka, Aaron J Hsueh

  Primary ovarian insufficiency (POI) and polycystic ovarian syndrome are ovarian diseases causing infertility. Although there is no effective treatment for POI, therapies for polycystic ovarian syndrome include ovarian wedge resection or laser drilling to induce follicle growth. Underlying mechanisms for these disruptive procedures are unclear. Here, we explored the role of the conserved Hippo signaling pathway that serves to maintain optimal size across organs and species. We found that fragmentation of murine ovaries promoted actin polymerization and disrupted ovarian Hippo signaling, leading to increased expression of downstream growth factors, promotion of follicle growth, and the generation of mature oocytes. In addition to elucidating mechanisms underlying follicle growth elicited by ovarian damage, we further demonstrated additive follicle growth when ovarian fragmentation was combined with Akt stimulator treatments. We then extended results to treatment of infertility in POI patients via disruption of Hippo signaling by fragmenting ovaries followed by Akt stimulator treatment and autografting. We successfully promoted follicle growth, retrieved mature oocytes, and performed in vitro fertilization. Following embryo transfer, a healthy baby was delivered. The ovarian fragmentation-in vitro activation approach is not only valuable for treating infertility of POI patients but could also be useful for middle-aged infertile women, cancer patients undergoing sterilizing treatments, and other conditions of diminished ovarian reserve.

  Oct. 2013, Proceedings of the National Academy of Sciences of the United States of America, 110(43) (43), 17474 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Oocyte-derived R-spondin2 promotes ovarian follicle development.

  Yuan Cheng, Kazuhiro Kawamura, Seido Takae, Masashi Deguchi, Qing Yang, Calvin Kuo, Aaron J W Hsueh

  R-spondin proteins are adult stem cell growth factors capable of stimulating gut development by activating LGR4, 5, and 6 receptors to promote Wnt signaling. Although multiple Wnt ligands and cognate Frizzled receptors are expressed in the ovary, their physiological roles are unclear. Based on bioinformatic and in situ hybridization analyses, we demonstrated the exclusive expression of R-spondin2 in oocytes of ovarian follicles. In cultured somatic cells from preantral follicles, R-spondin2 treatment (ED50: 3 ng/ml) synergized with Wnt3a to stimulate Wnt signaling. In cultured ovarian explants from prepubertal mice containing preantral follicles, treatment with R-spondin2, similar to follicle stimulating hormone, promoted the development of primary follicles to the secondary stage. In vivo administration of an R-spondin agonist stimulated the development of primary follicles to the antral stage in both immature mice and gonadotropin releasing hormone antagonist-treated adult mice. Subsequent treatment with gonadotropins allowed the generation of mature oocytes capable of undergoing early embryonic development and successful pregnancy. Furthermore, R-spondin agonist treatment of immune-deficient mice grafted with human cortical fragments stimulated the development of primary follicles to the secondary stage. Thus, oocyte-derived R-spondin2 is a paracrine factor essential for primary follicle development, and R-spondin agonists could provide a new treatment regimen for infertile women with low responses to the traditional gonadotropin therapy.

  Jun. 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6) (6), 2175 - 84, English, International magazine

  [Refereed]

  Scientific journal


• Correction: Actin Cytoskeleton Regulates Hippo Signaling.

  Pradeep Reddy, Masashi Deguchi, Yuan Cheng, Aaron J W Hsueh

  [This corrects the article on p. e73763 in vol. 8.].

  2013, PloS one, 8(9) (9), English, International magazine

  [Refereed]

  Scientific journal


• Actin cytoskeleton regulates Hippo signaling.

  Pradeep Reddy, Masashi Deguchi, Yuan Cheng, Aaron J W Hsueh

  Hippo pathway controls the organ size by modulating cell proliferation and apoptosis. However, the upstream regulation of hippo signaling by actin cytoskeleton is not clear. To elucidate the role of actin as an upstream regulator of Hippo signaling, the levels of F (filamentous)-actin in cells were elevated using jasplakinolide, an actin-stabilizing drug. Induction of F-actin formation in HeLa cells resulted in decreased phosphorylation of YAP, a key effector molecule for Hippo signaling. The activated YAP is localized to the cell nucleus and YAP increase was associated with increased expression of downstream CCN growth factors CCN1/CYR61 and CCN2/CTGF. The effect of the actin-stabilizing drug was blocked when YAP levels were suppressed in YAP "knock-down" cells. In summary, using an actin-stabilizing drug we show that actin cytoskeleton is one of the upstream regulators of Hippo signaling capable of activating YAP and increasing its downstream CCN growth factors.

  2013, PloS one, 8(9) (9), e73763, English, International magazine

  [Refereed]

  Scientific journal


• Large cell neuroendocrine carcinoma originating from the uterine endometrium: a report on magnetic resonance features of 2 cases with very rare and aggressive tumor.

  Natsuko Makihara, Tetsuo Maeda, Meiko Nishimura, Masashi Deguchi, Ayako Sonoyama, Koji Nakabayashi, Fumi Kawakami, Tomoo Itoh, Hideto Yamada

  Neuroendocrine carcinomas (NEC) of the female genital tract are aggressive and uncommon tumors, which usually involve the uterine cervix and ovary, and are seen very rarely in the endometrium. Only less than 10 cases of large cell NEC (LCNEC) of the endometrium have been reported in the literature and their radiological findings are not well described. We report here two cases of pathologically proven LCNEC of the uterine endometrium. In both cases, the uterine body was enlarged and the tumor occupied part of the uterine cavity. Endometrial mass exhibited heterogeneous high intensity on T2-weighted magnetic resonance (MR) images, and diffusion-weighted MR images revealed high intensity throughout the tumor, consistent with malignancy. LCNEC is a highly malignant neoplasm without particular findings in terms of diagnostic imaging and pathology, so its preoperative definitive diagnosis is very difficult. However, when laboratory test, pathologic diagnosis and MR imaging suggest a poorly differentiated uterine malignancy, positron emission tomography-computed tomography scan should be performed as a general assessment to help with diagnosis.

  Jun. 2012, Rare tumors, 4(3) (3), e37, English, International magazine

  [Refereed]

  Scientific journal


• Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatory period.

  Yuan Cheng, Kazuhiro Kawamura, Masashi Deguchi, Seido Takae, Sabine M Mulders, Aaron J W Hsueh

  In addition to its role in blood coagulation, thrombin directly stimulates protease-activated receptors (PAR) or interacts with thrombomodulin (THBD) to activate membrane-bound protein C which stimulates PAR1 and PAR4 receptors to promote downstream pleiotropic effects. Our DNA microarray, RT-PCR, and immunostaining analyses demonstrated ovarian expression of THBD, activated protein C (APC) receptor [endothelial protein C receptor (EPCR)], as well as PAR1 and PAR4 receptors in mice. After treatment of gonadotropin-primed immature mice with an ovulatory dose of human chorionic gonadotropin (hCG) (a LH surrogate), major increases in the expression of THBD, EPCR, PAR1, and PAR4 were detected in granulosa and cumulus cells of preovulatory follicles. Immunoassay analyses demonstrated sustained increases in ovarian prothrombin and APC levels after hCG stimulation. We obtained luteinizing granulosa cells from mice treated sequentially with equine CG and hCG. Treatment of these cells with thrombin or agonists for PAR1 or PAR4 decreased basal and forskolin-induced cAMP biosynthesis and suppressed hCG-stimulated progesterone production. In cultured preovulatory follicles, treatment with hirudin (a thrombin antagonist) and SCH79797 (a PAR1 antagonist) augmented hCG-stimulated progesterone biosynthesis, suggesting a suppressive role of endogenous thrombin in steroidogenesis. Furthermore, intrabursal injection with hirudin or SCH79797 led to ipsilateral increases in ovarian progesterone content. Our findings demonstrated increased ovarian expression of key components of the thrombin-APC-PAR1/4 signaling system after LH/hCG stimulation, and this signaling pathway may allow optimal luteinization of preovulatory follicles. In addition to assessing the role of thrombin and associated genes in progesterone production by the periovulatory ovary, these findings provide a model with which to study molecular mechanisms underlying thrombin-APC-PAR1/4 signaling.

  Feb. 2012, Molecular endocrinology (Baltimore, Md.), 26(2) (2), 331 - 40, English, International magazine

  [Refereed]

  Scientific journal


• Oocyte-expressed interleukin 7 suppresses granulosa cell apoptosis and promotes oocyte maturation in rats.

  Yuan Cheng, Ai Yata, Cynthia Klein, Joon-Ho Cho, Masashi Deguchi, Aaron J W Hsueh

  Development of ovarian follicles is regulated by pituitary-derived gonadotropins together with local ovarian paracrine factors. Based on DNA microarray data, we performed RT-PCR and immunostaining to demonstrate the expression of interleukin 7 transcripts in oocytes of preantral, antral, and preovulatory follicles in rats. We also found the expression of interleukin 7 receptor and the coreceptor interleukin 2 receptor gamma in granulosa cells, cumulus cells, and preovulatory oocytes. In cultured rat granulosa cells obtained from early antral and preovulatory follicles, treatment with interleukin 7 stimulated the phosphorylation of AKT, glycogen synthase kinase (GSK3B), and STAT5 proteins in a time- and dose-dependent manner. Furthermore, measurement of mitochondrial reductase activity indicated that treatment with interleukin 7, similar to gonadotropins, increased the number of viable granulosa cells during a 24-h culture period. Furthermore, monitoring of the activities of apoptotic enzymes (caspase 3/7) indicated that treatment with interleukin 7 suppressed apoptosis of cultured granulosa cells from both antral and preovulatory follicles following serum withdrawal. The apoptosis-suppressing actions of interleukin 7 were blocked by an inhibitor of the phosphoinositol-3-kinase (PIK3)/AKT pathway. Furthermore, treatment of cultured preovulatory follicles with interleukin 7, like treatment with human chorionic gonadotropin, induced germinal vesicle breakdown of oocytes. The stimulatory effect of interleukin 7 was also blocked by inhibitors of the PIK3/AKT pathway. The present findings suggest that oocyte-derived interleukin 7 could act on neighboring granulosa cells as a survival factor and promote the nuclear maturation of preovulatory oocytes through activation of the PIK3/AKT pathway.

  Apr. 2011, Biology of reproduction, 84(4) (4), 707 - 14, English, International magazine

  [Refereed]

  Scientific journal


• 転移巣に著明な石灰化を認めた卵巣癌術後6症例のFDG-PET/CT所見

  北島 一宏, 鈴木 加代, 尾西 由美子, 前田 哲雄, 大野 良治, 杉村 和朗, 中本 裕士, 千田 道雄, 出口 雅士, 山田 秀人, 北 正人

  (一社)日本核医学会, Feb. 2011, 核医学, 48(1) (1), 60 - 60, Japanese


• 卵巣腫瘍手術症例における下肢静脈血栓症術前診断の検討

  Deguchi Masashi

  Nov. 2009, 産婦人科の進歩, 61巻, 4号, pp. 413-413, Japanese

  International conference proceedings


• 卵巣甲状腺腫の術前画像診断に関する検討

  Deguchi Masashi

  Nov. 2009, 産婦人科の進歩, 61巻, 4号, pp. 413-413, Japanese

  International conference proceedings


• 腹腔鏡下卵巣腫瘍核出術時の工夫

  Morizane Mayumi, Deguchi Masashi

  Nov. 2009, 産婦人科の進歩, 61巻, 4号, pp. 424-424, Japanese

  International conference proceedings


• AFP産生性の子宮内膜癌の1症例

  Deguchi Masashi

  Nov. 2009, 産婦人科の進歩, 61巻, 4号, pp. 410-410, Japanese

  International conference proceedings


• 妊婦における2価陽イオンミネラルの尿中排泄動態

  Morizane Mayumi, Deguchi Masashi

  Jun. 2009, 日本周産期・新生児医学会雑誌, 45巻, 2号, pp. 656-656, Japanese

  International conference proceedings


• 完全型心内膜欠損症根治術既往褥婦が突然死をきたした症例

  Deguchi Masashi

  Jun. 2009, 日本周産期・新生児医学会雑誌, 45巻, 2号, pp. 685-685, Japanese

  International conference proceedings


• 消化管穿孔をきたした腹膜偽粘液腫症例の検討

  Deguchi Masashi, Yamasaki Mineo

  May 2009, 産婦人科の進歩, 61巻, 2号, pp. 196-196, Japanese

  International conference proceedings


• 悪性黒色腫に転化した卵巣成熟奇形腫の一例

  Deguchi Masashi, Yamasaki Mineo

  Nov. 2008, 産婦人科の進歩, 60巻, 4号, pp. 440-440, Japanese

  International conference proceedings


• 胎児中大脳動脈収縮期最大血流速度は正常であったが急速遂娩に至ったRh不適合妊娠例

  Morizane Mayumi, Deguchi Masashi, Yamasaki Mineo

  Jun. 2008, 日本周産期・新生児医学会雑誌, 44巻, 2号, pp. 612-612, Japanese

  International conference proceedings


• 出生前3次元超音波検査による肺体積測定の有用性の検討

  Morizane Mayumi, Deguchi Masashi, Yamasaki Mineo

  Jun. 2008, 日本周産期・新生児医学会雑誌, 44巻, 2号, pp. 561-561, Japanese

  International conference proceedings


• Association study of vascular endothelial growth factor gene polymorphisms in endometrial carcinomas in a Japanese population

  M. Amano, S. Yoshida, S. Kennedy, N. Takemura, M. Deguchi, N. Ohara, T. Maruo

  2008, EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 29(4) (4), 333 - 337, English

  [Refereed]

  Scientific journal


• Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population

  J. Morikawa, S. Yoshida, S. Kennedy, N. Takemura, M. Sugimoto, K. Kitao, M. Deguchi, N. Ohara, T. Maruo

  2008, CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 35(1) (1), 35 - 40, English

  Scientific journal


• Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population

  Deguchi Masashi, Ohara Noriyuki, Maruo Takeshi

  Jul. 2007, Gynecological Endocrinology, Vol. 23, No. 8, pp. 474-478, English

  Scientific journal


• 当院で経験した腹膜偽粘液腫11症例の検討

  矢田 愛, 中林 幸士, 浜名 伸也, 竹村 直也, 若橋 宣, 森川 淳子, 天野 真理子, 松岡 左希子, 出口 雅士, 吉田 茂樹, 山崎 峰夫, 丸尾 猛

  「産婦人科の進歩」編集室, May 2007, 産婦人科の進歩, 59(2) (2), 215 - 215, Japanese


• Epidermal growth factor receptor and human epidermal growth factor receptor 2 gene polymorphisms in endometrial cancer in a Japanese population

  Keisuke Kitao, Shigeki Yoshida, Stephen Kennedy, Naoya Takemura, Makoto Sugimoto, Masashi Deguchi, Noriyuki Ohara, Takeshi Maruo

  May 2007, REPRODUCTIVE SCIENCES, 14(4) (4), 349 - 357, English

  Scientific journal


• 子宮内膜症におけるVascular endomethelial growth factor遺伝子多型の解析

  OHARA NORIYUKI, KITAO KEISUKE, DEGUCHI MASASHI, MARUO TAKESHI

  Feb. 2007, 日本産科婦人科学会雑誌, 59巻, 2号, pp. 457-457, Japanese

  International conference proceedings


• 子宮体癌におけるvascular endothelial growth factor遺伝子多型の解析

  OHARA NORIYUKI, KITAO KEISUKE, DEGUCHI MASASHI, MARUO TAKESHI

  Feb. 2007, 日本産科婦人科学会雑誌, 59巻, 2号, pp. 383-383, Japanese

  International conference proceedings


• 子宮体癌におけるepidermal growth factor receptor,human epidermal growth factor receptor 2遺伝子多型の解析

  KITAO KEISUKE, OHARA NORIYUKI, DEGUCHI MASASHI, MARUO TAKESHI

  Feb. 2007, 日本産科婦人科学会雑誌, 59巻, 2号, pp. 384-384, Japanese

  International conference proceedings


• 子宮体癌におけるcatechol-O-methyltransferase遺伝子多型の解析

  DEGUCHI MASASHI, OHARA NORIYUKI, KITAO KEISUKE, MARUO TAKESHI

  Feb. 2007, 日本産科婦人科学会雑誌, 59巻, 2号, pp. 382-382, Japanese

  International conference proceedings


• 子宮筋腫におけるcatechol-O-methyltransferase遺伝子多型の解析

  OHARA NORIYUKI, DEGUCHI MASASHI, KITAO KEISUKE, MARUO TAKESHI

  日本産科婦人科学会, Feb. 2007, 日本産科婦人科学会雑誌, 59巻, 2号, pp. 628-628(2) (2), 628 - 628, Japanese

  International conference proceedings


• Vascular endothelial growth factor+936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population

  Yoshiyuki Ikuhashi, Shigeki Yoshida, Stephen Kennedy, Krina Zondervan, Naoya Takemura, Masashi Deguchi, Noriyuki Ohara, Takeshi Maruo

  2007, ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 86(11) (11), 1352 - 1358, English

  Scientific journal


• 当科で経験したPosterior reversible encephalopathy syndrome(PRES)の2症例

  KITAO KEISUKE, DEGUCHI MASASHI, OHARA NORIYUKI, MARUO TAKESHI

  Dec. 2006, 兵庫県母性衛生学会雑誌, 15号, pp. 77-79, Japanese

  [Refereed]

  Scientific journal


• 子宮内膜細胞診が発見の契機となった原発性腹膜癌の一例

  DEGUCHI MASASHI, YAMASAKI MINEO, MARUO TAKESHI

  Nov. 2006, 産婦人科の進歩, 58巻, 4号, pp. 508-508, Japanese

  International conference proceedings


• インスリンアナログによる糖尿病合併妊婦の治療 持効型溶解インスリンアナログを用いた1型糖尿病合併妊婦の管理経験

  KITAO KEISUKE, DEGUCHI MASASHI, Matsuoka Shozo, OHARA NORIYUKI, YAMASAKI MINEO, MARUO TAKESHI

  Oct. 2006, 糖尿病と妊娠, 6巻, 2号, pp. S50-S50, Japanese

  International conference proceedings


• Matrix metalloproteinase-1 and-9 promoter polymorphisms and endometrial carcinoma risk in a Japanese population

  Makoto Sugimoto, Shigeki Yoshida, Stephen Kennedy, Masashi Deguchi, Noriyuki Ohara, Takeshi Maruo

  Oct. 2006, JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 13(7) (7), 523 - 529, English

  Scientific journal


• 当科での子宮癌肉腫13症例の検討

  DEGUCHI MASASHI, YAMASAKI MINEO, MARUO TAKESHI

  Sep. 2006, 日本癌治療学会誌, 41巻, 2号, pp. 734-734, Japanese

  International conference proceedings


• 過去5年間に経験した腹膜偽粘液腫11症例の検討

  DEGUCHI MASASHI, YAMASAKI MINEO, MARUO TAKESHI

  Sep. 2006, 日本癌治療学会誌, 41巻, 2号, pp. 770-770, Japanese

  International conference proceedings


• 食道静脈瘤からの出血を繰り返したアルコール性肝硬変合併妊娠の管理経験

  DEGUCHI MASASHI, KITAO KEISUKE, YAMASAKI MINEO, MARUO TAKESHI

  Jun. 2006, 日本周産期・新生児医学会雑誌, 42巻, 2号, pp. 544-544, Japanese

  International conference proceedings


• 当科における産科出血に対する選択的子宮動脈塞栓術の現況

  DEGUCHI MASASHI, KITAO KEISUKE, OHARA NORIYUKI, MARUO TAKESHI

  近畿産科婦人科学会, May 2006, 産婦人科の進歩, 58巻, 2号, pp. 225-228(2) (2), 238 - 240, Japanese

  [Refereed]

  Scientific journal


• Matrix metalloproteinase-1 and-9 promoter polymorphisms are not associated with an increased risk of uterine leiomyomas in a Japanese population

  N Takemura, S Yoshida, S Kennedy, M Deguchi, N Ohara, T Maruo

  Apr. 2006, JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 13(3) (3), 232 - 236, English

  [Refereed]

  Scientific journal


• 子宮体癌発症におけるMatrix metalloproteinase-1,-9遺伝子多型の解析

  杉本誠, YOSHIDA, Shigeki, OHARA, Noriyuki, DEGUCHI, Masashi, 竹村直也, 生橋義之, 天野真理子, MARUO, Takeshi

  Feb. 2006, 日本産科婦人科学会雑誌, 58巻, 2号, pp.392-392, Japanese

  International conference proceedings


• 子宮筋腫におけるMatrix metalloproteinase(MMP)-1ならびにMMP-9遺伝子多型の解析

  竹村直也, YOSHIDA, Shigeki, OHARA, Noriyuki, 杉本誠, 生橋義之, 天野真理子, DEGUCHI, Masashi, MARUO, Takeshi

  日本産科婦人科学会, Feb. 2006, 日本産科婦人科学会雑誌, 58巻, 2号, pp.448-448(2) (2), 448 - 448, Japanese

  International conference proceedings


• The CYP17 MspAl polymorphism is not associated with an increased risk of uterine leiomyomas in a Japanese population

  T Tsujino, N Ohara, S Yoshida, S Kennedy, N Takemura, M Deguchi, T Maruo

  Feb. 2006, GYNECOLOGICAL ENDOCRINOLOGY, 22(2) (2), 87 - 91, English

  [Refereed]

  Scientific journal


• IVF-ET施行後に重症OHSSと左鎖骨下静脈血栓症を発症した2症例

  KITAO, Keisuke, 市田耕太郎, OHARA, Noriyuki, 鈴木嘉穂, 生橋義之, 斎田有紀, 森川哲, DEGUCHI, Masashi, MORITA, Hiroki, MARUO, Takeshi

  日本産科婦人科学会, Feb. 2006, 日本産科婦人科学会雑誌, 58巻, 2号, pp.503-503(2) (2), 503 - 503, Japanese

  International conference proceedings


• 肺リンパ脈管筋腫症合併妊娠の一例

  藤本美樹, 佐々木紘子, MORITA, Hiroki, DEGUCHI, Masashi, KITAO, Keisuke, OHARA, Noriyuki, MARUO, Takeshi

  Dec. 2005, 兵庫県母性衛生学会雑誌, 14号, pp.57-59, Japanese

  [Refereed]

  Scientific journal


• 当科における産科出血に対する選択的子宮動脈塞栓術の現況

  鈴木嘉穂, MORITA, Hiroki, 齋田有紀, 生橋義之, 森川哲, 市田耕太郎, DEGUCHI, Masashi, KITAO, Keisuke, OHARA, Noriyuki, MARUO, Takeshi

  近畿産科婦人科学会, Oct. 2005, 産婦人科の進歩, 57巻, 4号, pp.475-475(2) (2), 238 - 240, Japanese

  International conference proceedings


• 血管内発育子宮原発非上皮性腫瘍2例の経験

  竹村直也, YOSHIDA, Shigeki, HAMANA, Shinya, 高松裕幸, 杉本誠, 若橋宣, DEGUCHI, Masashi, NAKABAYASHI, Koji, MOTOYAMA,Satoru, MARUO, Takeshi

  Sep. 2005, 日本癌治療学会誌, 40巻, 2号, pp.613-613, Japanese

  International conference proceedings


• 肺リンパ脈管筋腫症合併妊娠の一例

  藤本美樹, 佐々木紘子, MORITA, Hiroki, DEGUCHI, Masashi, KITAO, Keisuke, FUNAKOSHI,Toru, OHARA, Noriyuki, MARUO, Takeshi

  May 2005, 産婦人科の進歩, 57巻, 2号, pp.256-256, Japanese

  International conference proceedings


• 子宮内膜症におけるN-acetyltransferase(NAT)1ならびにNAT2遺伝子領域におけるTDT(伝達不平衡)解析

  YOSHIDA, Shigeki, DEGUCHI, Masashi, 生橋義之, 竹村直也, 杉本誠, OHARA, Noriyuki, MARUO, Takeshi, スティーブン・ケネディー

  日本産科婦人科学会, Feb. 2005, 日本産科婦人科学会雑誌, 57巻, 2号, pp. 486-486(2) (2), 486 - 486, Japanese

  International conference proceedings


• 子宮内膜症におけるIntercellular adhesion molecule-1(ICAM-1)遺伝子多型の解析

  山下正子, YOSHIDA, Shigeki, DEGUCHI, Masashi, 生橋義之, 竹村直也, 杉本誠, OHARA, Noriyuki, MARUO, Takeshi, スティーブン・ケネディー

  日本産科婦人科学会, Feb. 2005, 日本産科婦人科学会雑誌, 57巻, 2号, pp. 487-487(2) (2), 487 - 487, Japanese

  International conference proceedings


• シスプラチン感受性卵巣癌細胞の増殖とアポトーシスに及ぼすImatinib mesylateの影響の検討

  DEGUCHI, Masashi, MOTOYAMA,Satoru, FernandezJovelle, HAMANA, Shinya, ベンジャミン・ツァン, MARUO, Takeshi

  日本産科婦人科学会, Feb. 2005, 日本産科婦人科学会雑誌, 57巻, 2号, pp. 616-616(2) (2), 616 - 616, Japanese

  International conference proceedings


• Lack of association between endometriosis and N-Acetyl Transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population

  DEGUCHI, Masashi, YOSHIDA, Shigeki, Kennedy Stephen, OHARA, Noriyuki, MOTOYAMA,Satoru, MARUO, Takeshi

  2005, Journal Of The Society For Gynecologic Investigation, Vol. 12, No. 3, pp. 208-213, English

  [Refereed]

  Scientific journal


• 当科における若年子宮体癌症例の検討

  竹村直也, 稲垣美恵子, DEGUCHI, Masashi, 浜名伸也, TAKEUCHI,Kyosuke, MOTOYAMA,Satoru, MARUO, Takeshi

  Jun. 2004, 日本婦人科腫瘍学会雑誌, 22巻, 3号, pp. 222-222, Japanese

  International conference proceedings


• A case of multiple ovarian cysts in a prepubertal girl with severe hypothyroidism due to autoimmune thyroiditis

  K Takeuchi, M Deguchi, Y Takeshima, T Maruo

  May 2004, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 14(3) (3), 543 - 545, English

  [Refereed]

  Scientific journal


• 日本人子宮内膜症におけるN-acetyltransferase(NAT)1ならびにNAT2遺伝子多型の解析

  DEGUCHI, Masashi, YOSHIDA, Shigeki, 大森伸也, 森實真由美, MARUO, Takeshi, スティーブン・ケネディー

  日本産科婦人科学会, Feb. 2004, 日本産科婦人科学会雑誌, 56巻, 2号, pp. 609-609(2) (2), 609 - 609, Japanese

  International conference proceedings


• 日本人子宮筋腫患者におけるCYP17 MspA1遺伝子多型の解析

  辻野太郎, OHARA, Noriyuki, YOSHIDA, Shigeki, 大森伸哉, 森實真由美, DEGUCHI, Masashi, MARUO, Takeshi, スティーブン・ケネディー

  日本産科婦人科学会, Feb. 2004, 日本産科婦人科学会雑誌, 56巻, 2号, pp. 415-415(2) (2), 415 - 415, Japanese

  International conference proceedings


• 子宮内膜症におけるN-acetyltransferase(NAT)1ならびにNAT2遺伝子多型の解析 家族性子宮内膜症と非家族性子宮内膜症の比較

  YOSHIDA, Shigeki, 大森伸哉, 森實真由美, DEGUCHI, Masashi, MARUO, Takeshi, ステイブン・ケネデイ

  日本産科婦人科学会, Feb. 2004, 日本産科婦人科学会雑誌, 56巻, 2号, pp. 609-609(2) (2), 340 - 340, Japanese

  International conference proceedings


• 子宮筋腫患者におけるERαならびにERβ遺伝子多型の解析

  大森伸哉, YOSHIDA, Shigeki, 辻野太郎, 森實真由美, DEGUCHI, Masashi, OHARA, Noriyuki, MARUO, Takeshi

  日本産科婦人科学会, Feb. 2004, 日本産科婦人科学会雑誌, 56巻, 2号, pp. 415-415(2) (2), 415 - 415, Japanese

  International conference proceedings


• 当科における子宮頸部悪性腺腫の診断

  MATSUOKA,Shozo, HAMANA, Shinya, TAKEUCHI,Kyosuke, 山中良彦, 大木規義, DEGUCHI, Masashi, 森實真由美, 高谷友紀子, MOTOYAMA,Satoru, MARUO, Takeshi

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2004, 産婦人科の進歩, 56巻, 2, pp. 113-115(2) (2), 113 - 115, Japanese


• Neoadjuvant high-dose intraarterial infusion chemotherapy under percutaneous pelvic perfusion with extracorporeal chemofiltration in patients with stages IIIa-IVa cervical cancer

  MOTOYAMA,Satoru, HAMANA, Shinya, Ku Yonson, Laoag-Fernandez Jovelle B, DEGUCHI, Masashi, YOSHIDA, Shigeki, TOMINAGA, Masahiro, IWASAKI, Takeshi, OHARA, Noriyuki, MARUO, Takeshi

  2004, Gynecologic Oncology, Vol. 95, No. 3, pp. 576-582, 576 - 582, English

  [Refereed]

  Scientific journal


• 卵巣未分化胚細胞腫の放射線治療後に生じた腟壁血管肉腫の一例

  DEGUCHI, Masashi, HAMANA, Shinya, TAKEUCHI,Kyosuke, YOSHIDA, Shigeki, MOTOYAMA,Satoru, MARUO, Takeshi

  Sep. 2003, 日本癌治療学会誌, 38巻, 2号, pp. 754-754, Japanese

  International conference proceedings


• 広汎性子宮全摘術後の排尿障害に対するウラピジル投与の有用性

  MOTOYAMA,Satoru, MATSUOKA,Shozo, 浜名伸也, DEGUCHI, Masashi, MARUO, Takeshi

  診断と治療社, Sep. 2003, 産科と婦人科, 70巻, 9号, pp. 1275-1279(9) (9), 1275 - 1279, Japanese

  [Refereed]

  Scientific journal


• 当院における子宮体癌の治療と予後成績

  DEGUCHI, Masashi, 高谷友紀子, HAMANA, Shinya, TAKEKIDA,Shigeru, YOSHIDA, Shigeki, TAKEUCHI,Kyosuke, MOTOYAMA,Satoru, MARUO, Takeshi

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, Aug. 2003, 産婦人科の進歩, 55巻, 3号, pp. 324-326(3) (3), 324 - 326, Japanese

  [Refereed]

  Scientific journal


• 当科における子宮頸部悪性腺腫の診断

  MATSUOKA,Shozo, 浜名伸也, TAKEUCHI,Kyosuke, 山中良彦, 大木規義, DEGUCHI, Masashi, 森實真由美, 高谷友紀子, MOTOYAMA,Satoru, MARUO, Takeshi

  May 2003, 産婦人科の進歩, 55巻, 2号, pp. 269-269, Japanese

  International conference proceedings


• 性早熟徴候と卵巣嚢腫を契機に診断された二次性甲状腺機能低下症の1例

  DEGUCHI, Masashi, 中島淳子, TAKEUCHI,Kyosuke, TAKEKIDA,Shigeru, HAMANA, Shinya, TAKESHIMA, Yasuhiro, MARUO, Takeshi

  「産婦人科の進歩」編集室, May 2003, 産婦人科の進歩, 55巻, 2号, pp. 256-256(2) (2), 256 - 256, Japanese

  International conference proceedings


• 産婦人科臨床における深在性真菌症の管理

  福永次雄, MOTOYAMA,Satoru, 千々和真理, HAMANA, Shinya, DEGUCHI, Masashi, MARUO, Takeshi

  Recently, there is an increased incidence of immunocompromised patients in medical fields. Frequent use of antibiotics, oncostatics, immunosuppressants and indwelling catheters lead to the causation of deep fungal infection. Deep fungal infection is fatal hence the proper diagnosis, management and prevention are of utmost importance.
  In the gynecologic department of our institution, we had 109 cases that showed recalcitrant exothermic reaction to antibiotics. CAND-TEC and FUNGI-TEC, which detect fungal antigen in the blood, were utilized. The treatment modality was determined in relation to the degree of severity of fungal infection based on the results obtained. The cut-off values used in this study for CAND-TEC and FUNGI-TEC were (4+) and 11.0 pg/ml, respectively. If the results were above the given values, they were categorized as serum positive indicative of an existing deep fungal infection.
  Comparison was made between serum positive and serum negative groups with regards to age, malignancy or benign disease, catheter use, leukocyte count, and c-reactive protein (CRP) values. In the serum fungus antigen positive group, 8.7% of the cases had benign diseases compared to 32.5% in the serum fungus antigen negative group. The difference was statistically significant (P<0.05). In the serum fungus antigen positive group, leukopenia of --4500/mm3 (52.1%) was significantly higher than that (12.5%) of antigen negative group (P<0.05). Moreover, the rate of death within one month from serum positivity (39.1%) in the serum fungus antigen positive group was higher than that (15.0%) in the serum fungus antigen negative group (P<0.05). This was also statistically significant.
  The investigation of existence of systemic fungal infection with the use of our institution's protocol was noted to increase the efficacy of therapy to 68.0% as compared to 35-50% effectivity of reported conventional therapy.[Adv Obstet Gynecol, 55 (2) 161-166, 2003 (H.15.5)]
  

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, May 2003, 産婦人科の進歩, 55巻, 2, pp. 161-166(2) (2), 161 - 166, Japanese


• 経皮的骨盤灌流化学療法

  MOTOYAMA,Satoru, HAMANA, Shinya, DEGUCHI, Masashi, YOSHIDA, Shigeki

  May 2003, 産婦人科の進歩, 55巻, 2号, pp. 239-239, Japanese

  International conference proceedings


• Super high-dose intraarterial infusion under percutaneous pelvic perfusion with extracorporeal chemofiltration for advanced uterine cervical carcinoma

  HAMANA Shinya, DEGUCHI Masashi, MIYAHARA Yoshiya, MOTOYAMA Satoru, MARUO Takeshi

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2003, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 55(1) (1), 49 - 51, Japanese


• 開腹術を要したまれな腹腔鏡下手術合併症の2例ー脾破裂症例と肉芽腫腹膜炎症例の検討ー

  大木規義, TAKEUCHI,Kyosuke, DEGUCHI, Masashi, 山田隆, MARUO, Takeshi

  2003, 医薬の門, 43巻, pp. 86-88, Japanese

  Scientific journal


• Simultaneous immunohistochemical localization of beta-catenin and cyclin D1 in differentiated but not in undifferentiated human endometrial carcinoma

  F Narita, A Sato, S Hamana, M Deguchi, T Otani, T Maruo

  2003, EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 24(2) (2), 129 - 134, English

  [Refereed]

  Scientific journal


• Granulomatous chemical peritonitis on the ileocecum after laparoscopic surgery of an ovarian mature cystic teratoma: Case report

  K. Takeuchi, M. Deguchi, Y. Oki, S. Takekida, S. Hamana, T. Maruo

  2002, Clinical and Experimental Obstetrics and Gynecology, 29(3) (3), 185 - 186, English

  Scientific journal


• 過去１２年間に当科で経験した妊娠合併卵巣癌症例の検討

  出口 雅士, 濱名 伸也, 武木田 茂樹, 立岩 洋一, 山辺 晋吾, 本山 覚, 丸尾 猛

  近畿産科婦人科学会, 2002, 産婦人科の進歩, 54(5) (5), 381 - 382, Japanese

• 妊娠とCOVID-19 第二報

  山田秀人, 山田秀人, 山田秀人, 出口雅士

  2022, 母性衛生, 62(4) (4)


• 【COVID-19-その診断と治療】妊婦における臨床像

  山田 秀人, 出口 雅士

  (株)ライフメディコム, Nov. 2021, カレントテラピー, 39(11) (11), 1081 - 1086, Japanese


• A case of severe postpartum HELLP syndrome with acute kidney injury that was successfully treated with plasma exchange

  原明子, 河野圭志, 藤井秀毅, 出口雅士, 西慎一

  (一社)日本透析医学会, Nov. 2021, 日本透析医学会雑誌, 54(11) (11), 597 - 602, Japanese


• エイズ文化フォーラム「防げる、防ごう、母子感染!〜ウイルス感染症〜」でのアンケート解析

  高野 政志, 出口 雅士, 羽柴 知恵子, 鈴木 ひとみ, 喜多 恒和

  (一社)日本性感染症学会, Nov. 2021, 日本性感染症学会誌, 32(2) (2), 101 - 101, Japanese


• 胎児発育不全児の予後不良に関連する因子の検討

  吉本 梓希子, 谷村 憲司, 久保田 いろは, 栖田 園子, 施 裕徳, 内田 明子, 白川 得朗, 今福 仁美, 出口 雅士, 寺井 義人

  「産婦人科の進歩」編集室, Oct. 2021, 産婦人科の進歩, 73(4) (4), 500 - 500, Japanese


• 妊娠とCOVID-19

  山田 秀人, 出口 雅士

  (公社)日本母性衛生学会, Jul. 2021, 母性衛生, 62(2) (2), 学8 - 学17, Japanese


• 【大規模災害時の周産期医療-災害に負けない準備と対応】感染症パンデミックへの対応 新型コロナウイルス感染症を踏まえて 母体と医療従事者への感染を防ぐには

  出口 雅士, 山田 秀人

  (株)医学書院, Jun. 2021, 臨床婦人科産科, 75(6) (6), 573 - 578, Japanese


• COVID-19と周産期医療 国内でのCOVID-19感染妊婦の現状 妊婦レジストリの解析結果(中間報告)

  出口 雅士, 施 裕徳, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2021, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P90 - P90, Japanese


• 非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例

  今福 仁美, 谷村 憲司, 益子 尚久, 内田 明子, 藤本 将史, 京野 由紀, 藤岡 一路, 出口 雅士, 寺井 義人

  (一社)日本周産期・新生児医学会, Jun. 2021, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, Japanese


• 胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する

  谷村 憲司, 施 裕徳, 内田 明子, 今福 仁美, 藤岡 一路, 森岡 一朗, 出口 雅士, 峰松 俊夫, 寺井 義人, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2021, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, Japanese


• 不育症と血栓性素因

  出口 雅士

  「産婦人科の進歩」編集室, May 2021, 産婦人科の進歩, 73(2) (2), 85 - 89, Japanese


• 胎児間輸血症候群によりabdominal compartment syndromeを発症した1症例

  益子 尚久, 谷村 憲司, 小畑 権大, 今福 仁美, 出口 雅士, 寺井 義人

  「産婦人科の進歩」編集室, May 2021, 産婦人科の進歩, 73(2) (2), 137 - 137, Japanese


• 不育症と子宮内膜マイクロバイオームとの関連

  施 裕徳, 谷村 憲司, 笹川 勇樹, 内田 明子, 尾崎 可奈, 白川 得朗, 今福 仁美, 出口 雅士, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 35 - 35, Japanese


• 梅毒合併妊娠8例の検討

  出口 雅士, 谷村 憲司, 施 裕徳, 内田 明子, 白川 得朗, 今福 仁美, 森實 真由美, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 43 - 43, Japanese


• 周産期母子医療センターでの先天性サイトメガロウイルス感染に関与する臨床所見

  今福 仁美, 谷村 憲司, 内田 明子, 施 裕徳, 笹川 勇樹, 白川 得朗, 出口 雅士, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 50 - 50, Japanese


• 産科一次施設における先天性サイトメガロウイルス感染症発生の臨床的リスク因子

  内田 明子, 谷村 憲司, 今福 仁美, 笹川 勇樹, 施 裕徳, 白川 得朗, 出口 雅士, 森實 真由美, 大橋 正伸, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 37回, 52 - 52, Japanese


• 国内での新型コロナウイルス感染妊婦の現状 妊婦レジストリ研究

  出口 雅士, 施 裕徳, 山田 秀人

  国内での新型コロナウイルス(COVID-19)妊婦症例の蓄積と解析が必要と考え、2020年9月よりレジストリー研究を開始した。2021年4月20日までに401名のCOVID-19感染妊婦が報告され61名のレジストリー登録が完了した。1)新型コロナウイルス感染妊婦の疾患登録システム(患者レジストリー)、2)新型コロナウイルス感染妊婦61名の概要、3)妊婦でのCOVID中等症・重症の危険因子、4)胎児感染、5)COVID感染妊婦からの出生児の管理、について述べた。

  (一社)日本産婦人科感染症学会, May 2021, 日本産婦人科感染症学会誌, 5(1) (1), 8 - 15, Japanese


• 子宮発生腺肉腫の1例 術前PET/MRI画像と病理標本との対比

  山本 雄也, 上野 嘉子, 松田 耕平, 野上 宗伸, 出口 雅士, 上原 慶一郎, 三木 智子, 村上 卓道

  症例は70歳代女性で、帯下、不正性器出血を主訴に受診し、子宮に腫瘤性病変を指摘された。MRIでは子宮体部に91×73×78mm大の腫瘤を認めた。画像所見からは子宮肉腫が疑われたが、由来部位が同定困難であり、非類内膜腺癌なども鑑別に挙げられた。腫瘤は複数の成分からなっており、T2強調像では腹側部は低信号、背頭部は比較的高信号、背尾側部は中程度の高信号を呈していた。18F-FDG PETでは腹側部はFDG集積が弱く、背頭部には軽度の集積、背尾部に強い集積を認めた。肉眼所見では子宮内腔に腫瘤が充満していた。画像所見にみられた腫瘍の各成分についての病理学的な特徴は以下のとおりであった。腫瘤腹側部には、異型の乏しい腺管構造が散見され、大小不同の核を呈する紡錘形細胞が認められた。腫瘤背頭部には、典型性の強い紡錘形細胞が多数認められ、正常な腺構造は認められなかった。腫瘤背頭部では、異型性の強い紡錘形細胞や壊死組織、炎症細胞が多数認められた。細胞密度は高く、正常な腺構造は認められなかった。根治的手術(子宮全摘術および両側付属器切除)が実施され、病理学的に腺肉腫の診断がなされた。子宮筋層の深部浸潤があり、pT1c FIGO IC期相当と判断された。術後特に問題なく退院となったが、術後2年3ヵ月で多発肺転移が生じた。全身状態良好であり、転移病変の増大が遅い点から経過観察の方針となり、術後3年9ヵ月時点では無症状で生存している。

  金原出版(株), Apr. 2021, 臨床放射線, 66(4) (4), 381 - 385, Japanese


• 慢性子宮内膜炎(CE)の子宮内pH測定による新しいCEフォロー法について

  遠藤 俊明, 板橋 詠子, 本間 寛之, 池田 詩子, 逸見 博文, 馬場 剛, 木谷 保, 施 裕徳, 出口 雅士, 山田 秀人, 齋藤 豪, 藤井 美穂

  (公社)日本産科婦人科学会, Mar. 2021, 日本産科婦人科学会雑誌, 73(臨増) (臨増), S - 340, Japanese


• 母子感染の話題~新型コロナウイルス,梅毒,トキソプラズマ,サイトメガロウイルス

  山田秀人, 出口雅士, 谷村憲司

  2021, 日本女性栄養・代謝学会誌, 27(1) (1)


• 完全型アンドロゲン不応症に対して腹腔鏡下性腺摘除術を施行した1例

  笹川勇樹, 出口雅士, 安積麻帆, 冨本雅子, 鷲尾佳一, 清水真帆, 長又哲史, 西本昌司, 山崎友維, 村田友香, 寺井義人

  2021, 日本産科婦人科内視鏡学会学術講演会(Web), 61st


• 胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する

  谷村憲司, 施裕徳, 内田明子, 今福仁美, 藤岡一路, 森岡一朗, 出口雅士, 峰松俊夫, 寺井義人, 山田秀人

  2021, 日本周産期・新生児医学会雑誌(Web), 57(Suppl) (Suppl)


• 非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例

  今福仁美, 谷村憲司, 益子尚久, 内田明子, 藤本将史, 京野由紀, 藤岡一路, 出口雅士, 寺井義人

  2021, 日本周産期・新生児医学会雑誌(Web), 57(Suppl) (Suppl)


• 先進医療下子宮体癌に対する腹腔鏡下傍大動脈リンパ節郭清術登録結果の検討

  鈴木 嘉穂, 高橋 良輔, 山中 啓太郎, 鷲尾 佳一, 清水 真帆, 長又 哲史, 村田 友香, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jan. 2021, 日本婦人科腫瘍学会雑誌, 39(1) (1), 115 - 115, Japanese


• 腹腔鏡下手術及び開腹手術との比較によるロボット支援下準広汎子宮全摘術導入の安全性に関する検討

  村田 友香, 鈴木 嘉穂, 山中 啓太郎, 安積 麻帆, 鷲尾 佳一, 清水 真帆, 高橋 良輔, 長又 哲史, 松本 培世, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jan. 2021, 日本婦人科腫瘍学会雑誌, 39(1) (1), 294 - 294, Japanese


• Saturated salt solution固定法Cadaverを用いた腹腔鏡下婦人科悪性腫瘍手術トレーニング

  長又 哲史, 山中 啓太郎, 安積 麻帆, 清水 真帆, 鷲尾 佳一, 高橋 良輔, 村田 友香, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jan. 2021, 日本婦人科腫瘍学会雑誌, 39(1) (1), 311 - 311, Japanese


• 後期高齢者における抗がん剤治療の安全性についての検討

  高橋 良輔, 山中 啓太郎, 安積 麻帆, 鷲尾 佳一, 清水 真帆, 長又 哲史, 村田 友香, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jan. 2021, 日本婦人科腫瘍学会雑誌, 39(1) (1), 318 - 318, Japanese


• A NOVEL AUTOANTIBODY AGAINST beta 2-GLYCOPROTEIN I/HLA CLASS II COMPLEXES IS A MAJOR RISK FACTOR FOR RECURRENT PREGNANCY LOSS

  Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Yuki Sasagawa, Masashi Deguchi, Noriko Arase, Hisashi Arase, Hideto Yamada

  Jan. 2021, PLACENTA, 103, 253 - 254, English

  Summary international conference


• ディベート-血栓性素因と不育症 プロテインS低下と不育症、産科異常

  出口 雅士

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 260 - 260, Japanese


• β2GPI/HLA-DR複合体は産科的抗リン脂質抗体症候群の自己抗体の標的である

  山田 秀人, 出口 雅士

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 309 - 309, Japanese


• 子宮内pHが新たな慢性子宮内膜炎のマーカーになる可能性について

  板橋 詠子, 遠藤 俊明, 本間 寛之, 池田 詩子, 逸見 博文, 木谷 保, 久野 芳佳, 森下 美幸, 馬場 剛, 齋藤 豪, 東口 篤司, 施 裕徳, 出口 雅士, 山田 秀人, 藤井 美穂

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 345 - 345, Japanese


• 精神疾患合併妊娠の妊娠中・産後増悪誘因ならびに児への影響に関する検討

  谷村 憲司, 施 裕徳, 内田 明子, 笹川 勇樹, 白川 得朗, 今福 仁美, 出口 雅士, 山田 秀人

  「産婦人科の進歩」編集室, Oct. 2020, 産婦人科の進歩, 72(4) (4), 458 - 458, Japanese


• 卵巣癌・原発性腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液cell block法の比較検討

  高橋 良輔, 清水 真帆, 長又 哲史, 松本 培世, 村田 友香, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  進行卵巣癌・原発性腹膜癌に対して術前化学療法(NAC)を行う際の主な診断方法として腹腔鏡下生検(LB)と体腔液の穿刺吸引細胞診がある。このうちLBは開腹手術に比べて低侵襲であり、診断の確実性からも有用な方法であるが、全身状態不良などの理由で腹腔鏡手術ですら躊躇する症例も少なくない。一方、穿刺吸引細胞診は全身状態不良な患者でも比較的安全に施行できるが、組織型の診断が困難という欠点がある。そこで、組織型の再現がしやすいcell block法(CB法)を穿刺吸引細胞診に取り入れている。今回、当院で2008〜2018年に進行卵巣癌もしくは原発性腹膜癌が疑われ治療された患者のうち、NAC施行時の診断目的にLBもしくはCB法を行い、根治手術時に病理診断が可能であった53例を対象とし、LB群(18例)とCB群(35例)に分け、「診断精度」「診断までに要した日数」「検査に伴う合併症」などについて群間比較した。結果、診断精度はLB群の全例で生検による診断と最終的な病理診断が一致していた。CB群では、漿液性癌の診断精度は高かったが、粘液性癌や癌肉腫では診断困難なケースが多かった。診断までに要した日数はLB群が平均8.9日、CB群が平均7.0日で、CB群ほうが有意に短かった。合併症の発生率に有意差は認めなかった。

  「産婦人科の進歩」編集室, Aug. 2020, 産婦人科の進歩, 72(3) (3), 211 - 215, Japanese


• 【[必携]専攻医と指導医のための産科診療到達目標】病態・疾患編【合併症妊娠】抗リン脂質抗体症候群

  山田 秀人, 谷村 憲司, 出口 雅士

  (株)東京医学社, Aug. 2020, 周産期医学, 50(8) (8), 1451 - 1453, Japanese


• 妊娠初期のプロテインS低値と産科異常との関連

  安積 麻帆, 出口 雅士, 清水 真帆, 笹川 勇樹, 森實 真由美, 谷村 憲司, 山田 秀人

  「産婦人科の進歩」編集室, May 2020, 産婦人科の進歩, 72(2) (2), 154 - 154, Japanese


• トキソプラズマIgG avidity index高値母体から発生した先天性トキソプラズマ感染疑いの1例

  谷村 憲司, 笹川 勇樹, 内田 明子, 今福 仁美, 出口 雅士, 藤岡 一路, 森岡 一朗, 笹井 美和, 山本 雅裕, 山田 秀人

  「産婦人科の進歩」編集室, May 2020, 産婦人科の進歩, 72(2) (2), 162 - 162, Japanese


• Sex cord tumor with annular tubulesの1例

  峯 凪り, 寺井 義人, 山中 啓太郎, 鷲尾 佳一, 清水 真帆, 高橋 良輔, 長又 哲史, 村田 友香, 鈴木 嘉穂, 出口 雅士, 山田 秀人

  「産婦人科の進歩」編集室, May 2020, 産婦人科の進歩, 72(2) (2), 169 - 169, Japanese


• 妊娠糖尿病妊婦におけるHeavy For Date児出生の予測因子

  益子 尚久, 谷村 憲司, 施 裕徳, 内田 明子, 笹川 勇樹, 白川 得郎, 今福 仁美, 出口 雅士, 山田 秀人

  「産婦人科の進歩」編集室, May 2020, 産婦人科の進歩, 72(2) (2), 177 - 177, Japanese


• 子宮筋腫の術前治療におけるGnRHアンタゴニストの有用性についての検討

  山中 啓太郎, 寺井 義人, 高橋 良輔, 鷲尾 佳一, 清水 真帆, 松本 培世, 長又 哲史, 村田 友香, 鈴木 嘉穂, 出口 雅士, 山田 秀人

  「産婦人科の進歩」編集室, May 2020, 産婦人科の進歩, 72(2) (2), 186 - 186, Japanese


• 【検査値を読む2020】(27章)性腺・胎盤検査 ヒト絨毛性ゴナドトロピン(hCG)

  出口 雅士

  (株)南江堂, Apr. 2020, 内科, 125(4) (4), 1021 - 1022, Japanese


• 【やさしくわかる 産科婦人科検査マスターブック】(第3章)生殖内分泌分野 抗リン脂質抗体

  出口 雅士, 谷村 憲司, 山田 秀人

  (株)診断と治療社, Mar. 2020, 産科と婦人科, 87(Suppl.) (Suppl.), 230 - 235, Japanese


• 卵巣癌において浸潤能,遊走能を促進する新規遺伝子の検索

  川口 徹也, 清水 真帆, 鷲尾 佳一, 高橋 良輔, 長又 哲史, 松本 培世, 村田 友香, 鈴木 嘉穂, 出口 雅士, 山田 秀人, 寺井 義人, 鈴木 聡

  (公社)日本産科婦人科学会, Mar. 2020, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 401, Japanese


• 当院における子宮頸癌に対するベバシズマブの使用経験

  長又 哲史, 山中 啓太郎, 鷲尾 佳一, 清水 真帆, 高橋 良輔, 松本 培世, 鈴木 嘉穂, 出口 雅士, 寺井 義人, 山田 秀人

  (公社)日本産科婦人科学会, Mar. 2020, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 490, Japanese


• 子宮頸癌に対する放射線治療後の不全骨折発症のリスク因子についての後方視的検討

  松本 培世, 鈴木 嘉穂, 鷲尾 佳一, 清水 真帆, 高橋 良輔, 長又 哲史, 村田 友香, 出口 雅士, 山田 秀人, 寺井 義人

  (公社)日本産科婦人科学会, Mar. 2020, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 535, Japanese


• 当院におけるロボット支援下手術の導入と腹腔鏡手術との比較検討

  鈴木 嘉穂, 長又 哲史, 山中 啓太郎, 鷲尾 佳一, 清水 真帆, 高橋 良輔, 松本 培世, 村田 友香, 出口 雅士, 山田 秀人, 寺井 義人

  (公社)日本産科婦人科学会, Mar. 2020, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 627, Japanese


• BevacizumabとOlaparibの併用療法によって再発卵巣癌治療は変わったか?

  高橋 良輔, 鈴木 嘉穂, 山中 啓太郎, 鷲尾 佳一, 清水 真帆, 長又 哲史, 松本 培世, 村田 友香, 出口 雅士, 山田 秀人, 寺井 義人

  (公社)日本産科婦人科学会, Mar. 2020, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 643, Japanese


• 【母子感染症の必修知識-エキスパートに学び予防につなげる】総論 母子感染スクリーニング方法と診断の話題

  山田 秀人, 谷村 憲司, 出口 雅士

  (株)東京医学社, Jan. 2020, 小児内科, 52(1) (1), 23 - 29, Japanese


• 【母子感染症の必修知識-エキスパートに学び予防につなげる】総論 母子感染スクリーニング方法と診断の話題

  山田 秀人, 谷村 憲司, 出口 雅士

  (株)東京医学社, Jan. 2020, 小児内科, 52(1) (1), 23 - 29, Japanese


• HIV母子感染予防のcART 「HIV母子感染予防対策マニュアル(第8版)」および「HIV感染妊娠に関する診療ガイドライン(初版)より

  白野 倫徳, 山田 里佳, 谷口 晴記, 塚原 優己, 井上 孝実, 出口 雅士, 中西 豊, 鳥谷部 邦明, 大里 和広, 千田 時弘, 杉野 祐子, 羽柴 知恵子, 渡邊 英恵, 杉浦 敦, 吉野 直人, 定月 みゆき, 田中 瑞恵, 桃原 祥人, 喜多 恒和

  (一社)日本エイズ学会, Nov. 2019, 日本エイズ学会誌, 21(4) (4), 455 - 455, Japanese


• 血栓性素因と妊娠

  出口 雅士

  (一社)日本検査血液学会, Nov. 2019, 日本検査血液学会雑誌, 20(3) (3), 455 - 463, Japanese


• 当院における子宮頸癌に対するベバシズマブの使用経験

  長又 哲史, 清水 真帆, 高橋 良輔, 松本 培世, 村田 友香, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  「産婦人科の進歩」編集室, Oct. 2019, 産婦人科の進歩, 71(4) (4), 419 - 419, Japanese


• HIV感染予防の最近の話題-PrEP、U=Uなどの話題とともに- HIV母子感染予防マニュアルについて 挙児希望HIV感染者の感染予防の紹介

  山田 里佳, 谷口 晴記, 塚原 優己, 井上 孝実, 白野 倫徳, 出口 雅士, 中西 豊, 鳥谷部 邦明, 大里 和広, 千田 時弘, 杉野 祐子, 羽柴 知恵子, 渡邊 英恵, 定月 みゆき, 田中 瑞恵, 喜多 恒和

  (一社)日本性感染症学会, Oct. 2019, 日本性感染症学会誌, 30(2) (2), 212 - 212, Japanese


• 当院における子宮頸癌に対するベバシズマブの使用経験

  長又 哲史, 清水 真帆, 高橋 良輔, 松本 培世, 村田 友香, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  「産婦人科の進歩」編集室, Oct. 2019, 産婦人科の進歩, 71(4) (4), 419 - 419, Japanese


• 妊娠と自己免疫疾患の管理 ITPの免疫グロブリン大量療法を含めて

  出口 雅士

  日本女性栄養・代謝学会, Sep. 2019, 日本女性栄養・代謝学会学術集会プログラム・抄録集, 43回, 44 - 44, Japanese


• 全身性エリテマトーデス合併妊娠における産科異常のリスク因子

  白川 得朗, 窪田 詩乃, 出口 雅士, 谷村 憲司, 森實 真由美, 山田 秀人

  日本女性栄養・代謝学会, Sep. 2019, 日本女性栄養・代謝学会学術集会プログラム・抄録集, 43回, 61 - 61, Japanese


• 子宮頸部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討

  木原 智子, 蝦名 康彦, 今福 仁美, 長又 哲史, 上中 美月, 鈴木 嘉穂, 出口 雅士, 山田 秀人

  日本女性栄養・代謝学会, Sep. 2019, 日本女性栄養・代謝学会学術集会プログラム・抄録集, 43回, 64 - 64, Japanese


• Prognostic nutritional index(PNI)と卵巣癌患者の予後に関する検討

  松本 培世, 蝦名 康彦, 長又 哲史, 高橋 良輔, 清水 真帆, 安積 麻帆, 鈴木 嘉穂, 出口 雅士, 山田 秀人

  日本女性栄養・代謝学会, Sep. 2019, 日本女性栄養・代謝学会学術集会プログラム・抄録集, 43回, 65 - 65, Japanese


• β2グリコプロテインI/HLAクラスII複合体に対するネオ・セルフ抗体は不育症の新たなリスク因子である

  谷村 憲司, 齋藤 滋, 中塚 幹也, 藤井 知行, 出口 雅士, 山田 秀人

  (公社)日本母性衛生学会, Sep. 2019, 母性衛生, 60(3) (3), 162 - 162, Japanese


• 症候性先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性

  谷村 憲司, 内田 明子, 今福 仁美, 森實 真由美, 出口 雅士, 藤岡 一路, 森岡 一朗, 峰松 俊夫, 山田 秀人

  (一社)日本産婦人科感染症学会, Sep. 2019, 日本産婦人科感染症学会誌, 3(1) (1), 87 - 87, Japanese


• トキソプラズマ抗体妊婦スクリーニングに関する前向きコホート研究

  内田 明子, 谷村 憲司, 西川 鑑, 清水 亜由美, 施 裕徳, 田中 恵里加, 森實 真由美, 出口 雅士, 蝦名 康彦, 森岡 一朗, 山田 秀人

  (一社)日本産婦人科感染症学会, Sep. 2019, 日本産婦人科感染症学会誌, 3(1) (1), 88 - 88, Japanese


• HBV妊婦スクリーニングと母子感染予防の前向き研究

  笹川 勇樹, 谷村 憲司, 山名 哲司, 森實 真由美, 出口 雅士, 森岡 一朗, 山田 秀人

  (一社)日本産婦人科感染症学会, Sep. 2019, 日本産婦人科感染症学会誌, 3(1) (1), 91 - 91, Japanese


• Autoantibody against beta2-glycoprotein I/HLA class II complex as a risk factor for recurrent pregnancy loss

  Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Yuki Sasagawa, Masashi Deguchi, Noriko Arase, Hisashi Arase, Hideto Yamada

  Sep. 2019, LUPUS, 28, 54 - 54, English

  Summary international conference


• 当科における腹腔鏡下子宮悪性腫瘍手術の導入と治療成績

  長又 哲史, 安積 麻帆, 清水 真帆, 高橋 良輔, 松本 培世, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  (一社)日本産科婦人科内視鏡学会, Aug. 2019, 日本産科婦人科内視鏡学会雑誌, 35(Suppl.I) (Suppl.I), 281 - 281, Japanese


• 血栓性素因と妊娠

  出口 雅士

  (一社)日本検査血液学会, Jun. 2019, 日本検査血液学会雑誌, 20(学術集会) (学術集会), S221 - S222, Japanese


• 不育症の新たなリスク因子としての抗β2グリコプロテインI/HLAクラスII複合体抗体

  谷村 憲司, 齋藤 滋, 中塚 幹也, 永松 健, 藤井 知行, 笹川 勇樹, 出口 雅士, 福井 淳史, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2019, 日本周産期・新生児医学会雑誌, 55(2) (2), 431 - 431, Japanese


• 日本におけるHIV感染妊娠に関する診療ガイドライン初版とHIV母子感染予防対策マニュアル第7版の改訂

  鳥谷部 邦明, 谷口 晴記, 吉野 直人, 杉浦 敦, 定月 みゆき, 桃原 祥人, 出口 雅士, 大里 和広, 喜多 恒和, 厚生労働科学研究費補助金エイズ対策政策研究事業「HIV感染者の妊娠・出産・予後に関する疫学的・コホート的調査研究と情報の普及啓発法の開発ならびに診療体制の整備と均てん化に関する研究」班

  (一社)日本周産期・新生児医学会, Jun. 2019, 日本周産期・新生児医学会雑誌, 55(2) (2), 528 - 528, Japanese


• 母体PVB19感染の妊娠管理と予防

  白川 得朗, 森實 真由美, 谷村 憲司, 出口 雅士, 蝦名 康彦, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2019, 日本周産期・新生児医学会雑誌, 55(2) (2), 529 - 529, Japanese


• 難治性抗リン脂質抗体症候群への免疫グロブリン療法

  島岡 昌生, 出口 雅士, 前澤 陽子, 谷村 憲司, 森實 真由美, 蝦名 康彦, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2019, 日本周産期・新生児医学会雑誌, 55(2) (2), 565 - 565, Japanese


• 卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較

  鈴木 嘉穂, 中筋 由紀子, 安積 麻帆, 高橋 良輔, 長又 哲史, 松本 培世, 出口 雅士, 蝦名 康彦, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, Japanese


• 卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討

  高橋 良輔, 鈴木 嘉穂, 中筋 由紀子, 安積 麻帆, 長又 哲史, 松本 培世, 出口 雅士, 蝦名 康彦, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, Japanese


• 子宮頸がんに対する放射線治療後不全骨折発症のリスクについての検討

  松本 培世, 鈴木 嘉穂, 安積 麻帆, 中筋 由紀子, 清水 真帆, 高橋 良輔, 長又 哲史, 蝦名 康彦, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 476 - 476, Japanese


• トラベクテジンの長期投与が可能であった平滑筋肉腫の二例

  長又 哲史, 蝦名 康彦, 安積 麻帆, 高橋 良輔, 松本 培世, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 525 - 525, Japanese


• 妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討

  安積 麻帆, 鈴木 嘉穂, 中筋 由紀子, 高橋 良輔, 松本 培世, 長又 哲史, 出口 雅士, 寺井 義人, 山田 秀人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, Japanese


• 胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例

  鷲尾 佳一, 上中 美月, 白川 得朗, 谷村 憲司, 森實 真由美, 出口 雅士, 山田 秀人

  日本女性栄養・代謝学会, Jun. 2019, 日本女性栄養・代謝学会誌, 25, 59 - 60, Japanese


• メトホルミンが著効したインスリン抵抗症合併妊娠の1例

  上中 美月, 鷲尾 佳一, 出口 雅士, 谷村 憲司, 森實 真由美, 山田 秀人

  日本女性栄養・代謝学会, Jun. 2019, 日本女性栄養・代謝学会誌, 25, 67 - 68, Japanese


• 卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較

  鈴木 嘉穂, 中筋 由紀子, 安積 麻帆, 高橋 良輔, 長又 哲史, 松本 培世, 出口 雅士, 蝦名 康彦, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, Japanese


• 卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討

  高橋 良輔, 鈴木 嘉穂, 中筋 由紀子, 安積 麻帆, 長又 哲史, 松本 培世, 出口 雅士, 蝦名 康彦, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, Japanese


• 子宮頸がんに対する放射線治療後不全骨折発症のリスクについての検討

  松本 培世, 鈴木 嘉穂, 安積 麻帆, 中筋 由紀子, 清水 真帆, 高橋 良輔, 長又 哲史, 蝦名 康彦, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 476 - 476, Japanese


• トラベクテジンの長期投与が可能であった平滑筋肉腫の二例

  長又 哲史, 蝦名 康彦, 安積 麻帆, 高橋 良輔, 松本 培世, 鈴木 嘉穂, 出口 雅士, 寺井 義人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 525 - 525, Japanese


• 妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討

  安積 麻帆, 鈴木 嘉穂, 中筋 由紀子, 高橋 良輔, 松本 培世, 長又 哲史, 出口 雅士, 寺井 義人, 山田 秀人

  (公社)日本婦人科腫瘍学会, Jun. 2019, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, Japanese


• 「HIV母子感染マニュアル第8版」改訂内容について

  山田 里佳, 谷口 晴記, 塚原 優己, 井上 孝実, 白野 倫徳, 出口 雅士, 中西 豊, 鳥谷部 邦明, 大里 和広, 千田 時弘, 杉野 祐子, 羽柴 知恵子, 渡邊 英恵, 杉浦 敦, 吉野 直人, 定月 みゆき, 田中 瑞恵, 桃原 祥人, 喜多 恒和, 厚生労働科学研究費補助金エイズ対策政策研究事業「HIV感染者の妊娠・出産・予後に関する疫学的・コホート的調査研究と情報の普及啓発法の開発ならびに診療体制の整備と均てん化に関する研究」班

  (一社)日本産婦人科感染症学会, May 2019, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 36回, 42 - 42, Japanese


• 妊娠中に維持透析療法を要した慢性腎不全合併妊娠3症例

  黒島 瑞穂, 谷村 憲司, 森實 真由美, 出口 雅士, 山田 秀人

  妊娠中に維持透析療法を要した慢性腎不全(CRF)合併妊娠3症例の臨床経過を調べ、周産期管理の問題点を検討した。症例1(43歳、G3P2)は腎血管性高血圧によるCRF患者で、妊娠26週に透析導入したが、高血圧が持続するため、Dry Weight(DW)を漸減したところ、羊水過少傾向を示し、胎児発育不全(FGR)となった。症例2(40歳、G1P0)は、IgA腎症によるCRFにて38歳時に透析導入となり、妊娠中期からDWを漸増したところ、羊水過多症を合併した。症例3(37歳、G1P0)は、膀胱尿管逆流症によるCRFにて18歳時に透析導入となり、血圧コントロールの目的でDWを漸減したところ、羊水過少傾向となったが、重篤なFGRは認めなかった。3例とも早産で、2例が極低出生体重児であった。維持透析を要する妊婦の管理には産科、新生児科、腎臓内科の綿密な連携が必須であることが示唆された。

  「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 103 - 108, Japanese


• 当院で経験した腹膜原発癌肉腫の2例

  中筋 由紀子, 鈴木 嘉穂, 長又 哲史, 安積 麻帆, 高橋 良輔, 松本 培世, 蝦名 康彦, 出口 雅士, 寺井 義人, 山田 秀人

  「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 230 - 230, Japanese


• 当院で経験した腹膜原発癌肉腫の2例

  中筋 由紀子, 鈴木 嘉穂, 長又 哲史, 安積 麻帆, 高橋 良輔, 松本 培世, 蝦名 康彦, 出口 雅士, 寺井 義人, 山田 秀人

  「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 230 - 230, Japanese


• 妊娠中に維持透析療法を要した慢性腎不全合併妊娠3症例

  黒島 瑞穂, 谷村 憲司, 森實 真由美, 出口 雅士, 山田 秀人

  妊娠中に維持透析療法を要した慢性腎不全(CRF)合併妊娠3症例の臨床経過を調べ、周産期管理の問題点を検討した。症例1(43歳、G3P2)は腎血管性高血圧によるCRF患者で、妊娠26週に透析導入したが、高血圧が持続するため、Dry Weight(DW)を漸減したところ、羊水過少傾向を示し、胎児発育不全(FGR)となった。症例2(40歳、G1P0)は、IgA腎症によるCRFにて38歳時に透析導入となり、妊娠中期からDWを漸増したところ、羊水過多症を合併した。症例3(37歳、G1P0)は、膀胱尿管逆流症によるCRFにて18歳時に透析導入となり、血圧コントロールの目的でDWを漸減したところ、羊水過少傾向となったが、重篤なFGRは認めなかった。3例とも早産で、2例が極低出生体重児であった。維持透析を要する妊婦の管理には産科、新生児科、腎臓内科の綿密な連携が必須であることが示唆された。

  「産婦人科の進歩」編集室, May 2019, 産婦人科の進歩, 71(2) (2), 103 - 108, Japanese


• 不育症の診断と治療

  出口 雅士

  (公社)日本産科婦人科学会, Feb. 2019, 日本産科婦人科学会雑誌, 71(臨増) (臨増), S - 40, Japanese


• 日本におけるHIV感染妊娠に関する診療ガイドライン初版とHIV母子感染予防対策マニュアル第7版の改訂について

  山田 里佳, 喜多 恒和, 谷口 晴記, 塚原 優己, 井上 孝実, 千田 時弘, 大里 和広, 中西 豊, 定月 みゆき, 鳥谷部 邦明, 杉浦 敦, 桃原 祥人, 出口 雅士, HIV感染者の妊娠・出産・予後に関する疫学的・コホート的調査研究と情報の普及啓発法の開発ならびに診療体制の整備と均てん化に関する研究

  (公社)日本産科婦人科学会, Feb. 2019, 日本産科婦人科学会雑誌, 71(臨増) (臨増), S - 453, Japanese


• 正常胎児と全奇胎の双胎(complete hydatidiform mole coexistent with a fetus)の3症例

  吉澤 ひかり, 蝦名 康彦, 今福 仁美, 鈴木 嘉穂, 若橋 宣, 宮原 義也, 出口 雅士, 山田 秀人

  過去10年間に当科で経験した正常胎児と全奇胎の双胎(CHMCF)3例について報告した。CHMCFの診断週数は12〜14週で、2例は排卵誘発による妊娠であった。母体合併症は妊娠悪阻が1例、性器出血が3例であった。診断後、妊娠継続に関するリスクについて十分な説明を行ったところ、2例は妊娠中絶を希望したが、残りの1例は希望により妊娠継続をしていた。だが、臨床的侵入奇胎のため妊娠21週1日目で人工妊娠中絶となった。3例中2例では続発性疾患(奇胎後hCG存続症1例、臨床的侵入奇胎1例)を認め、化学療法にて寛解が得られた。

  「産婦人科の進歩」編集室, Feb. 2019, 産婦人科の進歩, 71(1) (1), 9 - 16, Japanese


• 妊娠初期のプロテインS低値と産科異常との関連

  出口 雅士, 谷村 憲司, 蝦名 康彦, 山田 秀人

  日本生殖免疫学会, Nov. 2018, Reproductive Immunology and Biology, 33(1-2) (1-2), 110 - 110, Japanese


• HIV感染妊娠に関する診療ガイドライン初版とHIV母子感染予防対策マニュアル第7版の比較

  山田 里佳, 喜多 恒和, 吉野 直人, 杉浦 敦, 田中 瑞恵, 定月 みゆき, 桃原 祥人, 谷口 晴記, 塚原 優己, 井上 孝美, 千田 時弘, 大里 和広, 中西 豊, 白野 倫徳, 鳥谷部 邦明, 杉野 祐子, 羽柴 知恵子, 出口 雅士, 厚労科研エイズ対策政策研究事業HIV感染者の妊娠、出産、予後に関する疫学的、コホート的調査研究と情報の普及啓発法の開発ならびに診療体制の整備と均てん化に関する研究班

  (一社)日本エイズ学会, Nov. 2018, 日本エイズ学会誌, 20(4) (4), 467 - 467, Japanese


• Neoself antibody as a risk factor for recurrent pregnancy loss

  Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Yuki Sasagawa, Masashi Deguchi, Yasuhiko Ebina, Noriko Arase, Hisashi Arase, Hideto Yamada

  Nov. 2018, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 130, 32 - 32, English

  Summary international conference


• 不育症リスク因子としてのネオ・セルフ抗体

  谷村 憲司, 齋藤 滋, 中塚 幹也, 永松 健, 藤井 知行, 笹川 勇樹, 出口 雅士, 蝦名 康彦, 荒瀬 規子, 荒瀬 尚, 山田 秀人

  日本生殖免疫学会, Nov. 2018, Reproductive Immunology and Biology, 33(1-2) (1-2), 93 - 93, Japanese


• 不育症診療の現状と課題 さらなる妊娠予後改善にむけて

  出口 雅士, 山田 秀人

  (公社)日本母性衛生学会, Sep. 2018, 母性衛生, 59(3) (3), 49 - 49, Japanese


• 子宮頸部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討

  木原 智子, 出口 雅士, 蝦名 康彦, 上中 美月, 鈴木 嘉穂, 宮原 義也, 山田 秀人

  (公社)日本母性衛生学会, Sep. 2018, 母性衛生, 59(3) (3), 238 - 238, Japanese


• 神戸大学における不育症の臨床因子と妊娠予後の検討

  宮地 真帆, 出口 雅士, 今福 仁美, 谷村 憲司, 森實 真由美, 蝦名 康彦, 山田 秀人

  (公社)日本母性衛生学会, Sep. 2018, 母性衛生, 59(3) (3), 293 - 293, Japanese


• 分娩後出血に対するUAEの帰結およびUAE後の妊娠についての検討

  今福 仁美, 森實 真由美, 谷村 憲司, 出口 雅士, 山田 秀人

  (公社)日本母性衛生学会, Sep. 2018, 母性衛生, 59(3) (3), 311 - 311, Japanese


• 不育症のトピックス 不育症とネオ・セルフ

  谷村 憲司, 笹川 勇樹, 今福 仁美, 森實 真由美, 出口 雅士, 蝦名 康彦, 荒瀬 規子, 荒瀬 尚, 齋藤 滋, 山田 秀人

  (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 230 - 230, Japanese


• 胎児発育不全児の予後不良に関連する因子の検討

  吉澤 ひかり, 谷村 憲司, 内山 美穂子, 白國 あかり, 森實 真由美, 出口 雅士, 藤岡 一路, 森岡 一朗, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 548 - 548, Japanese


• 維持透析療法を要した腎不全合併妊娠3例

  黒島 瑞穂, 谷村 憲司, 笹川 勇樹, 白川 得朗, 今福 仁美, 森實 真由美, 出口 雅士, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 615 - 615, Japanese


• 妊婦のB型肝炎スクリーニングと垂直感染予防

  笹川 勇樹, 谷村 憲司, 山名 哲司, 森實 真由美, 出口 雅士, 森岡 一朗, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 636 - 636, Japanese


• 先天性サイトメガロウイルス感染の胎盤病理

  上中 美月, 森實 真由美, 谷村 憲司, 出口 雅士, 森岡 一朗, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 638 - 638, Japanese


• 症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療

  谷村 憲司, 内田 明子, 今福 仁美, 森實 真由美, 出口 雅士, 藤岡 一路, 森岡 一朗, 峰松 俊夫, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 638 - 638, Japanese


• トキソプラズマ妊婦スクリーニングの前向きコホート研究

  内田 明子, 谷村 憲司, 西川 鑑, 里吉 雅恵, 清水 亜由美, 施 裕徳, 田中 恵里加, 森實 真由美, 出口 雅士, 蝦名 康彦, 森岡 一朗, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 689 - 689, Japanese


• 当院不育症外来における不育症リスク因子と治療成績

  白川 得朗, 出口 雅士, 宮地 真帆, 森實 真由美, 谷村 憲司, 蝦名 康彦, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2018, 日本周産期・新生児医学会雑誌, 54(2) (2), 710 - 710, Japanese


• HBV妊婦スクリーニングと母子感染予防の前向き研究

  笹川 勇樹, 谷村 憲司, 山名 哲司, 森實 真由美, 出口 雅士, 森岡 一朗, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2018, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 35回, 54 - 54, Japanese


• サイトメガロウイルス母子感染の対策

  山田秀人, 森岡一朗, 出口雅士, 谷村憲司, 平久進也, 森實真由美, 蝦名康彦, 峰松俊夫

  (一社)日本産婦人科感染症学会, 2018, 日本産婦人科感染症学会誌, 2(1) (1), 2 - 12, Japanese

  Introduction scientific journal


• The distribution of etiology and therapy outcomes of recurrent pregnancy loss at Kobe University recurrent pregnancy loss clinic

  Maho Miyaji, Masashi Deguchi, Yoko Maesawa, Kenji Tanimura, Mayumi Morizane, Hideto Yamada

  Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 76 - 76, English

  Summary international conference


• M1 macrophages increase in the deciduae of miscarriages with normal fetal chromosome

  Shigeki Shimada, Yasuhiko Ebina, Masashi Deguchi, Hideto Yamada

  Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 81 - 82, English

  Summary international conference


• Efficacy of antiviral treatment on abnormal auditory brainstem responses in congenital cytomegalovirus-infected infants

  Ichiro Morioka, Shohei Ohyama, Sachiyo Fukushima, Kosuke Nishida, Keiji Yamana, Kazumichi Fujioka, Kazumoto Iijima, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Hideto Yamada

  Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 80 - 81, English

  Summary international conference


• Neurological outcomes at 18 months of age and neonatal risk factors for severe sequelae in congenitally cytomegalovirus-infected infants treated by antiviral treatment early in life

  Ichiro Morioka, Sachiyo Fukushima, Shohei Ohyama, Kosuke Nishida, Keiji Yamana, Kazumichi Fujioka, Kazumoto Iijima, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Hideto Yamada

  Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 80 - 80, English

  Summary international conference


• A prospective study of maternal toxoplasma screening with use of IgG avidity index and PCR method

  Yutoku Shi, Masashi Deguchi, Kenji Tanimura, Akiko Uchida, Erika Tanaka, Ryosuke Takahashi, Maho Miyaji, Mayumi Morizane, Yasuhiko Ebina, Ichro Morioka, Ayumi Shimizu, Akira Nishikawa, Hideto Yamada

  Nov. 2017, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 124, 81 - 81, English

  Summary international conference


• 抗リン脂質抗体症候群合併妊娠において産科異常と関連する因子

  出口 雅士, 杉浦 真弓, 森川 守, 藤田 太輔, 三木 明徳, 牧野 真太郎, 山田 秀人, 村島 温子

  日本妊娠高血圧学会, Sep. 2017, 日本妊娠高血圧学会雑誌, 24, 76 - 76, Japanese


• 胎児を守るためのウイルス感染対策 (特集 感染対策の視点で考える乳幼児のウイルス感染症)

  出口 雅士, 森實 真由美, 蝦名 康彦, 山田 秀人

  診断と治療社, May 2017, チャイルドヘルス, 20(5) (5), 346 - 351, Japanese


• サイトメガロウイルス (特集 周産期のウイルス感染症) -- (妊娠・分娩・産褥時の対応)

  山田 秀人, 谷村 憲司, 出口 雅士, 蝦名 康彦, 森岡 一朗, 峰松 俊夫

  東京医学社, Feb. 2017, 周産期医学, 47(2) (2), 213 - 218, Japanese


• 胎児腹水を呈した症候性先天性サイトメガロウイルス感染症3例の出生後の臨床経過

  西田浩輔, 森岡一朗, Deguchi Masashi, 谷村憲司, 平久進也, 蝦名康彦, 山田秀人

  (公社)日本産科婦人科学会, Feb. 2017, 日本産科婦人科学会雑誌, 69(2号) (2号), 1024 - 1024, Japanese

  Meeting report


• サイトメガロウイルス感染に対する妊婦抗体スクリーニング

  市橋さなえ, 谷村憲司, 平久進也, 長又哲史, 尾崎可奈, 出口雅士, 森實真由美, 蝦名康彦, 森岡一朗, 峰松俊夫, 山田秀人

  2017, 母性衛生, 58(3) (3)


• トキソプラズマ妊婦スクリーニングの前向きコホート研究

  施裕徳, 出口雅士, 西川鑑, 清水亜由美, 谷村憲司, 内田明子, 田中恵里加, 森實真由美, 蝦名康彦, 森岡一朗, 山田秀人

  2017, Reproductive Immunology and Biology, 32(1-2) (1-2)


• トキソプラズマ妊婦スクリーニングの前向き研究

  田中恵里加, 谷村憲司, 高橋良輔, 平久進也, 森實真由美, 出口雅士, 蝦名康彦, 森岡一朗, 清水亜由美, 西川鑑, 山田秀人

  2017, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 34th


• Association between low levels of plasma protein S and recurrent pregnancy loss or perinatal complications

  Masashi Deguchi, Nanae Shinozaki, Yasuhiko Ebina, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 143 - 143, English

  Summary international conference


• Natural killer cell activity in women with recurrent miscarriage

  Yasuhiko Ebina, Yukari Nishino, Masashi Deguchi, Yoko Maesawa, Yuki Nakajima, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 132 - 132, English

  Summary international conference


• Antiphospholipid syndrome and anti-prothrombin/HLA-DR antibody

  Satoko Morikami, Kenji Tanimura, Masashi Deguchi, Yasuhiko Ebina, Noriko Arase, Koyuki Hirayasu, Tadahiro Suenaga, Masako Kohyama, Tatsuya Atsumi, Hideto Yamada, Hisashi Arase

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 117 - 117, English

  Summary international conference


• Effectiveness of maternal serological screening for congenital cytomegalovirus infection

  Shinya Tairaku, Kenji Tanimura, Ichiro Morioka, Kana Ozaki, Satoshi Nagamata, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Toshio Minematsu, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 119 - 119, English

  Summary international conference


• Autoantibodies against beta 2-glycoprotein I/HLA class II complexes may have the potential for improving diagnosis of antiphospholipid syndrome

  Kenji Tanimura, Masashi Deguchi, Yasuhiko Ebina, Hisashi Arase, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 145 - 146, English

  Summary international conference


• High dose intravenous immunoglobulin therapy for pregnancy with aspirin-heparin resistant antiphospholipid syndrome

  Yoko Maesawa, Masashi Deguchi, Shinya Tairaku, Mayumi Morizane, Kenji Tanimura, Yasuhiko Ebina, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 116 - 116, English

  Summary international conference


• High and moderate dose intravenous immunoglobulin therapy for women with recurrent miscarriage of unexplained etiology

  Masashi Deguchi, Yoko Maesawa, Kana Ozaki, Kenji Tanimura, Mayumi Morizane, Yasuhiko Ebina, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 131 - 132, English

  Summary international conference


• Six cases of parvovirus B19 infection in pregnancy

  Saki Sato, Mayumi Morizane, Daisuke Ueda, Yoko Maesawa, Shinya Tairaku, Kenji Tanimura, Masashi Deguchi, Yasuhiko Ebina, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 120 - 120, English

  Summary international conference


• The management of pregnancies complicated with antithrombin deficiency: A report of 23 cases

  Mayumi Morizane, Kana Ozaki, Yoko Maesawa, Shinya Tairaku, Kenji Tanimura, Masashi Deguchi, Yasuhiko Ebina, Hideto Yamada

  Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 113 - 113, English

  Summary international conference


• 抗リン脂質抗体症候群における抗Prothrombin/HLA-DR抗体

  森上 聡子, 谷村 憲司, 出口 雅士, 蝦名 康彦, 荒瀬 規子, 平安 恒幸, 末永 忠広, 香山 雅子, 渥美 達也, 山田 秀人, 荒瀬 尚

  日本生殖免疫学会, Nov. 2016, Reproductive Immunology and Biology, 31(1-2) (1-2), 110 - 110, Japanese


• A NOVEL AUTOANTIBODY IS ASSOCIATED WITH RECURRENT MISCARRIAGE

  Kenji Tanimura, Masashi Deguchi, Mayumi Morizane, Yasuhiko Ebina, Hisashi Arase, Hideto Yamada

  Oct. 2016, PLACENTA, 46, 108 - 108, English

  Summary international conference


• VASA PREVIA PRENATALLY DIAGNOSED BY ULTRASOUND SCANNING AND MAGNETIC RESONANCE IMAGING; REPORT OF 3 CASES

  Erika Tanaka, Mayumi Morizane, Mihoko Uchiyama, Masashi Deguchi, Utaru Tanaka, Tetsuo Maeda, Hideto Yamada

  Oct. 2016, PLACENTA, 46, 109 - 109, English

  Summary international conference


• PREDICTION OF ADHERENT PLACENTA WITH PLACENTA PREVIA USING A NOVEL SCORING SYSTEM

  Ryosuke Takahashi, Kenji Tanimura, Masashi Deguchi, Mayumi Morizane, Hideto Yamada

  Oct. 2016, PLACENTA, 46, 108 - 108, English

  Summary international conference


• 新生児同種免疫性血小板減少症の3例

  内山 美穂子, 出口 雅士, 平久 進也, 森本 規之, 森實 真由美, 谷村 憲司, 香田 翼, 森岡 一朗, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2016, 日本周産期・新生児医学会雑誌, 52(2) (2), 678 - 678, Japanese


• 免疫学的異常と免疫グロブリン療法 (特集 不育症Up to Date)

  山田 秀人, 出口 雅士, 蝦名 康彦

  診断と治療社, May 2016, 産科と婦人科, 83(5) (5), 535 - 539, Japanese


• 妊婦のサイトメガロウイルス抗体スクリーニングの有用性

  平久進也, 谷村憲司, 森岡一朗, 尾崎可奈, 長又哲史, 森實真由美, 出口雅士, 蝦名康彦, 峰松俊夫, 山田秀人

  2016, Reproductive Immunology and Biology, 31(1/2) (1/2)


• リスク因子不明習慣流産に対する100gおよび60g免疫グロブリン療法の効果

  出口雅士, 前澤陽子, 尾崎可奈, 谷村憲司, 森實真由美, 蝦名康彦, 山田秀人

  2016, Reproductive Immunology and Biology, 31(1/2) (1/2)


• ISP-17-1 Clinical features of obstetrical antiphospholipid syndrome in the Japanese population : A multicenter study(Group 17 Perinatal Care 1,International Session Poster) :

  Deguchi Masashi, Yamada Hideto, Fujita Daisuke, Sugiura Mayumi, Morikawa Mamoru, Miki Akinori, Makino Shintaro, Murashima Atsuko

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 525 - 525, English


• P2-63-6 流産脱落膜および非妊娠時子宮内膜におけるCD4+T細胞, CD8+T細胞, 制御性T細胞(Group63 子宮移植・子宮内膜,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

  森上 聡子, 蝦名 康彦, 島田 茂樹, 前澤 陽子, 出口 雅士, 山田 秀人

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 809 - 809, Japanese


• P3-51-9 帝王切開術後にMycoplasma hominis腹膜炎を発症した3例(Group 116 周産期の感染症2,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

  大原 雅代, 出口 雅士, 出口 可奈, 前澤 陽子, 谷村 憲司, 森實 真由美, 平久 進也, 小嶋 伸恵, 篠崎 奈々絵, 山田 秀人

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 983 - 983, Japanese


• ISP-34-5 Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss(Group 34 Infertility/Recurrent Pregnancy Loss,International Session Poster) :

  Shinozaki Nanae, Ebina Yasuhiko, Deguchi Masashi, Tanimura Kenji, Morizane Mayumi, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 577 - 577, English


• ISP-27-1 Pregnancy after uterine artery embolization for the treatment of post-partum hemorrhage : a case series(Group 27 Maternal Complication 3,International Session Poster) :

  Morizane Mayumi, Yamasaki Yui, Maesawa Yoko, Tairaku Shinya, Morimoto Noriyuki, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 555 - 555, English


• ISP-26-6 To assess the management of pregnancies complicated with antithrombin deficiency : A report of 20 cases(Group 26 Maternal Complication 2,International Session Poster) :

  Deguchi Kana, Morizane Mayumi, Morikami Satoko, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 554 - 554, English


• ISP-23-3 Maternal blood screening for congenital cytomegalovirus infection of the infants(Group 23 Maternal Complication 1,International Session Poster) :

  Tairaku Shinya, Tanimura Kenji, Morioka Ichiro, Nagamata Satoshi, Deguchi Masashi, Ebina Yasuhiko, Minematsu Toshio, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 545 - 545, English


• ISP-25-5 Postpartum screening for glucose intolerance in women with gestational diabetes mellitus(Group 25 Nutrition and Metabolism,International Session Poster) :

  Kojima Nobue, Tanimura Kenji, Uenaka Mizuki, Shinozaki Nanae, Deguchi Masashi, Morizane Mayumi, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 550 - 550, English


• ISP-23-2 The effect of maternal screening for HBV and perinatal HBV prevention program(Group 23 Maternal Complication 1,International Session Poster) :

  Sasagawa Yuki, Deguchi Masashi, Takeda Akiko, Tanimura Kenji, Morizane Mayumi, Morioka Ichirou, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 544 - 544, English


• P2-55-5 妊娠初期にパルボウイルスB19に感染した4例(Group55 周産期の感染症1,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

  佐藤 沙貴, 森實 真由美, 上田 大介, 前澤 陽子, 平久 進也, 谷村 憲司, 出口 雅士, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 781 - 781, Japanese


• IS-MW-5-2 Prediction of adherent placenta with placenta previa using a novel scoring system(Group 5 Perinatology 2,International Session Mini Workshop) :

  Tanimura Kenji, Deguchi Masashi, Morizane Mayumi, Yamada Hideto

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 474 - 474, English


• P2-45-1 子宮動脈塞栓術後に保存的治療抵抗性の子宮内膜筋層炎を発症し子宮摘出に至った2例(Group45 産科手術1,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

  長又 哲史, 篠崎 奈々絵, 森實 真由美, 谷村 憲司, 出口 雅士, 山田 秀人

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 744 - 744, Japanese


• P3-42-11 新生児同種免疫性血小板減少症の2例 : 過去の妊娠で児が新生児同種免疫性血小板減少症を発症した女性の周産期管理(Group 107 合併症妊娠9,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)

  上中 美月, 森實 真由美, 平久 進也, 谷村 憲司, 出口 雅士, 森岡 一朗, 山田 秀人

  日本産科婦人科学会, 2016, 日本産科婦人科學會雜誌, 68(2) (2), 950 - 950, Japanese


• 抗リン脂質抗体症候群合併妊娠 診療ガイドライン

  村島温子, 渥美達也, 井上永介, 大田えりか, 奥健志, 小澤伸晃, 金子佳代子, 後藤美賀子, 齋藤滋, 杉浦真弓, 関口将軌, 高橋尚人, Deguchi Masashi, 中山雅弘, 野澤和久, 平井千裕, 藤田太輔, 松岡健太郎, 松木祐子, MariaOlgaAmengualPriego, 三木明徳, 光田信明, 森臨太郎, 山田秀人, 山本亮, 横山健次, 和田芳直

  2016, 抗リン脂質抗体症候群合併妊娠 診療ガイドライン, 20 - 31, Japanese

  [Refereed]

  Introduction other


• Intravenous immunoglobulin therapy for treatment of recurrent pregnancy loss

  Masashi Deguchi

  Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 143 - 143, English

  Summary international conference


• Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss

  Nanae Shinozaki, Yasuhiko Ebina, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Hideto Yamada

  Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 137 - 137, English

  Summary international conference


• Prediction of high-risk patients for adverse pregnancy outcome based on multivariate logistic regression analysis in early pregnancy

  Yasuhiko Ebina, Masashi Deguchi, Kenji Tanimura, Hideto Yamada

  Nov. 2015, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112, 135 - 135, English

  Summary international conference


• 抗リン脂質抗体症候群女性の妊娠中の管理状況に関する多施設症例調査

  出口 雅士, 山田 秀人, 藤田 太輔, 杉浦 真弓, 森川 守, 三木 明徳, 牧野 真太郎, 村島 温子

  日本生殖免疫学会, Nov. 2015, Reproductive Immunology and Biology, 30(1-2) (1-2), 110 - 110, Japanese


• PREDICTION OF ADHERENT PLACENTA IN PATIENTS WITH PLACENTA PREVIA USING ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING

  Kenji Tanimura, Yui Yamasaki, Yoshiko Ueno, Tetsuo Maeda, Yasuhiko Ebina, Masashi Deguchi, Mayumi Morizane, Hideto Yamada

  Oct. 2015, PLACENTA, 36(10) (10), A5 - A6, English

  Summary international conference


• 抗リン脂質抗体症候群女性の妊娠中の管理状況に関する多施設症例調査

  出口 雅士, 藤田 太輔, 三木 明徳, 牧野 真太郎, 山田 秀人, 村島 温子

  (一社)日本周産期・新生児医学会, Jun. 2015, 日本周産期・新生児医学会雑誌, 51(2) (2), 925 - 925, Japanese


• 新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率

  西田 浩輔, 森岡 一朗, 香田 翼, 長坂 美和子, 岩谷 壮太, 出口 雅士, 谷村 憲司, 平久 進也, 船越 徹, 大橋 正伸, 飯島 一誠, 山田 秀人

  (一社)日本周産期・新生児医学会, Jun. 2015, 日本周産期・新生児医学会雑誌, 51(2) (2), 663 - 663, Japanese


• 新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率

  森岡 一朗, 西田 浩輔, 香田 翼, 岩谷 壮太, 出口 雅士, 谷村 憲司, 平久 進也, 蝦名 康彦, 船越 徹, 大橋 正伸, 飯島 一誠, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2015, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 32回, 37 - 37, Japanese


• 症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果と問題点

  森岡 一朗, 西田 浩輔, 香田 翼, 岩谷 壮太, 出口 雅士, 谷村 憲司, 平久 進也, 蝦名 康彦, 飯島 一誠, 山田 秀人

  (一社)日本産婦人科感染症学会, May 2015, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 32回, 38 - 38, Japanese


• P3-43-7 中期流死産歴を有する抗リン脂質抗体症候群合併妊娠に対する治療効果(Group145 合併症妊娠8,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  山野 由美香, 出口 雅士, 谷村 憲司, 山崎 友維, 篠崎 奈々絵, 前澤 陽子, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 933 - 933, Japanese


• P2-30-3 血漿プロテインS低値の女性に対する遺伝子診断と妊娠時の治療法選択(Group 71 不育症 臨床,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  篠崎 奈々絵, 出口 雅士, 上中 美月, 山崎 友維, 平久 進也, 森實 真由美, 谷村 憲司, 蝦名 康彦, 森田 宏紀, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 725 - 725, Japanese


• P2-30-8 不育症患者における生化学的妊娠既往と妊娠予後(Group 71 不育症 臨床,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  前澤 陽子, 出口 雅士, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 727 - 727, Japanese


• P2-58-3 18番染色体短腕欠損が原因と考えられた全前脳胞症の1症例(Group 99 胎児異常1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  山崎 友維, 上中 美月, 平久 進也, 篠崎 奈々絵, 森實 真由美, 谷村 憲司, 出口 雅士, 宮原 義也, 蝦名 康彦, 森田 宏紀, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 806 - 806, Japanese


• P2-59-7 抗SS-A抗体陽性妊婦の胎児大動脈-上大静脈房室伝導時間スクリーニングと先天性完全房室ブロックの発症予防(Group 100 胎児異常2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  荒井 貴子, 平久 進也, 谷村 憲司, 金子 めぐみ, 篠崎 奈々絵, 出口 雅士, 森岡 一朗, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 811 - 811, Japanese


• P3-54-8 切迫早産入院管理の結果,妊娠29週未満で早産となった児の予後解析(Group 156 早産6,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  宇治田 直也, 谷村 憲司, 平久 進也, 篠崎 奈々絵, 出口 雅士, 森岡 一朗, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 967 - 967, Japanese


• P1-27-5 免疫グロブリンを用いたサイトメガロウイルス胎児感染予防と胎児治療(Group27 感染症1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  上中 美月, 谷村 憲司, 金子 めぐみ, 鷲尾 佳一, 出口 可奈, 平久 進也, 篠崎 奈々絵, 森實 真由美, 出口 雅士, 蝦名 康彦, 森岡 一朗, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 602 - 602, Japanese


• P1-31-1 Marfan症候群合併妊娠の3例(Group31 合併症妊娠2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  鷲尾 佳一, 上中 美月, 平久 進也, 篠崎 奈々絵, 谷村 憲司, 出口 雅士, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 613 - 613, Japanese


• P1-36-8 巨大胎盤内血腫, Breus' moleの2例(Group36 胎盤2,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  金子 めぐみ, 出口 雅士, 山崎 友維, 篠崎 奈々絵, 西本 昌司, 上中 美月, 平久 進也, 谷村 憲司, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 631 - 631, Japanese


• ISP-15-1 A rapid increase of serum IgG avidity index in women with congenital cytomegalovirus infection(Group 15 Perinatology 5,IS Poster,International Session) :

  Deguchi Masashi, Ebina Yasuhiko, Minematsu Toshio, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Sonoyama Ayako, Nagamata Satoshi, Morizane Mayumi, Yamada Hideto

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 1042 - 1042, English


• ISP-11-3 Low levels of plasma protein S, protein C, and coagulation factor XII during early pregnancy and adverse pregnancy outcome(Group 11 Perinatology 1,IS Poster,International Session) :

  Ebina Yasuhiko, Kobashi Gen, Deguchi Masashi, Minakami Hisanori, Yamada Hideto

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 1031 - 1031, English


• NW-9-1 先天性トキソプラズマ感染の出生前予測に有用なトキソプラズマIgG avidity index cut-off値(ミニワークショップ9 周産期ウイルス感染,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  谷村 憲司, 西川 鑑, 平久 進也, 篠崎 奈々絵, 森實 真由美, 出口 雅士, 森岡 一朗, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 512 - 512, Japanese


• NW-9-2 サイトメガロウイルスIgM陽性妊婦における先天性感染発生の予知因子(ミニワークショップ9 周産期ウイルス感染,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

  平久 進也, 蝦名 康彦, 森岡 一朗, 荒井 貴子, 園山 綾子, 谷村 憲司, 出口 雅士, 峰松 俊夫, 山田 秀人

  日本産科婦人科学会, 2015, 日本産科婦人科學會雜誌, 67(2) (2), 512 - 512, Japanese


• 周産期の炎症・感染への挑戦 先天性サイトメガロウイルス感染の効果的な周産期管理法の確立を目指して

  森岡 一朗, 平久 進也, 蝦名 康彦, Tanimura Kenji, Deguchi Masashi, 園山 綾子, 峰松 俊夫, 井上 直樹, 飯島 一誠, 山田 秀人

  Jan. 2015, 日本周産期・新生児医学会雑誌, 50(別冊) (別冊), 22 - 23, Japanese

  Meeting report


• Genetic analysis for women with protein S deficiency

  N. Shinozaki, M. Deguchi, K. Tanimura, Y. Ebina, H. Yamada

  Dec. 2014, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 106, 8 - 8, English

  Summary international conference


• 免疫グロブリン投与によるサイトメガロウイルス母子感染予防の試み

  出口 可奈, Tanimura Kenji, 平久 進也, 篠崎 奈々絵, Morizane Mayumi, Deguchi Masashi, 蝦名 康彦, 森岡 一朗, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 485, Japanese

  Meeting report


• 先天性トキソプラズマ感染症の出生前予測に有用なトキソプラズマIgG avidity index cut-off値

  Tanimura Kenji, 西川 鑑, 平久 進也, 篠崎 奈々絵, Morizane Mayumi, Deguchi Masashi, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 484, Japanese

  Meeting report


• 症候性先天性サイトメガロウイルス感染に対する免疫グロブリンを用いた胎児治療

  上中 美月, Tanimura Kenji, 鷲尾 佳一, 平久 進也, 篠崎 奈々絵, Morizane Mayumi, Deguchi Masashi, 蝦名 康彦, 森岡 一朗, 山田 秀人

  Oct. 2014, 産婦人科の進歩, 66(4号) (4号), 485, Japanese

  Meeting report


• 受容体以後のシグナル伝達障害によるインスリン抵抗性を合併し、妊娠中もメトホルミン投与を要した一例

  鷲尾 佳一, 上中 美月, 篠崎 奈々絵, Morizane Mayumi, 谷村 憲司, Deguchi Masashi, 山田 秀人, 平田 悠, 西本 祐希, 廣田 勇士, 小川 渉

  Oct. 2014, 糖尿病と妊娠, 14(2号) (2号), S - 88, Japanese

  Meeting report


• 【妊娠と薬物治療ガイドブック】 妊婦の薬物療法の実際 合併症妊娠のリスクと薬剤選択時の留意点 産科感染症(TORCH症候群)

  Deguchi Masashi, Yamada Hideto

  Sep. 2014, 調剤と情報, 20(11号) (11号), 1312 - 1320, Japanese

  Introduction scientific journal


• バセドウ病合併妊娠における産科異常と新生児甲状腺機能異常発症の危険因子の検討

  上中 美月, Tanimura Kenji, 平久 進也, 篠崎 奈々絵, Morizane Mayumi, Deguchi Masashi, 蝦名 康彦, 森岡 一朗, 山田 秀人

  Sep. 2014, 日本内分泌学会雑誌, 90(2号) (2号), 512, Japanese

  Meeting report


• Polymerization of Actin Promotes Ovarian Follicle Growth Mediated By the Hippo Signaling Effector YAP

  Yuan Cheng, Kazuhiro Kawamura, Masashi Deguchi, Yorino Sato, Yi Feng, Aaron J. W. Hsueh

  Jun. 2014, ENDOCRINE REVIEWS, 35(3) (3), English

  Summary international conference


• 胎盤トキソプラズマ感染を認めた2症例

  Deguchi Masashi, 松岡 正造, 白川 得朗, 小嶋 伸恵, 平久 進也, 篠崎 奈々絵, Suzuki Kaho, Tanimura Kenji, 森岡 一朗, 山田 秀人

  Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 801, Japanese

  Meeting report


• 子宮体癌根治術における廓清リンパ節および子宮筋層にリンパ脈管筋腫症細胞を認めた一例

  森田 宏紀, 山崎 友維, 白川 友香, 平久 進也, Suzuki Kaho, 今福 仁美, 生橋 義之, Deguchi Masashi, 宮原 義也, 新谷 潔, 蝦名 康彦, 川上 史, 山田 秀人

  (公社)日本婦人科腫瘍学会, Jun. 2014, 日本婦人科腫瘍学会雑誌, 32(3) (3), 590 - 590, Japanese

  Meeting report


• 近年日本における母子感染の実態

  平久 進也, 森岡 一朗, 蝦名 康彦, 園山 綾子, Tanimura Kenji, Deguchi Masashi, 山田 秀人

  Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 779, Japanese

  Meeting report


• インスリン治療を要した妊娠糖尿病妊婦の臨床像

  小嶋 伸恵, 白川 得朗, 平久 進也, 篠崎 奈々絵, Tanimura Kenji, Deguchi Masashi, 松岡 正造, 山田 秀人

  Jun. 2014, 日本周産期・新生児医学会雑誌, 50(2号) (2号), 870, Japanese

  Meeting report


• 妊娠に関連した高安病の6症例

  中島 由貴, Deguchi Masashi, 内田 明子, 市橋 さなえ, 出口 可奈, 西野 由香里, 西本 昌司, 白川 得朗, 小嶋 伸恵, 平久 進也, Suzuki Kaho, 篠崎 奈々絵, 松岡 正造, 山田 秀人

  May 2014, 産婦人科の進歩, 66(2号) (2号), 243, Japanese

  Meeting report


• 習慣流産の検査と治療について

  Deguchi Masashi

  May 2014, 産婦人科の進歩, 66(2号) (2号), 185 - 186, Japanese

  [Invited]

  Others


• 子宮下部から子宮前壁を走行する卵膜血管を認めた2例

  西野 由香里, 松岡 正造, Deguchi Masashi, 市橋 さなえ, 内田 明子, 中島 由貴, 西本 昌司, 白川 得朗, 小嶋 伸恵, 平久 進也, Suzuki Kaho, 篠崎 奈々絵, 山田 秀人

  May 2014, 産婦人科の進歩, 66(2号) (2号), 216, Japanese

  Meeting report


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  笹川 勇樹, 蝦名 康彦, 長又 哲史, 園山 綾子, 伊勢 由香里, 森岡 一朗, 平久 進也, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, 山田 秀人

  May 2014, 産婦人科の進歩, 66(2号) (2号), 250, Japanese

  Meeting report


• 妊娠35週より急速に増大した胎児脳腫瘍の1例

  山崎 友維, 宮原 義也, 平久 進也, 篠崎 奈々絵, Deguchi Masashi, 森田 宏紀, 山田 秀人

  Mar. 2014, 超音波医学, 41(2号) (2号), 265, Japanese

  Meeting report


• 【一般小児科医のための新生児対応パーフェクトガイド】 母子感染が疑われる児への対応 サイトメガロウイルス抗体・トキソプラズマ抗体

  Morioka Ichiro, Yamada Hideto, 平久 進也, Ebina Yasuhiko, Deguchi Masashi, 香田 翼, Iijima Kazumoto

  Mar. 2014, 小児科診療, 77(3号) (3号), 347 - 350, Japanese

  [Refereed]

  Introduction commerce magazine


• 不育症および自己免疫疾患における抗リン脂質抗体陽性患者の妊娠帰結

  宮原 義也, Deguchi Masashi, 篠崎 奈々絵, Tanimura Kenji, 蝦名 康彦, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 585, Japanese

  Meeting report


• 妊娠35週より急速に増大した胎児脳腫瘍の1例

  内田 明子, 山崎 友維, 牧原 夏子, 生橋 義之, 松岡 正造, Deguchi Masashi, 宮原 義也, 森田 宏紀, 蝦名 康彦, 山田 秀人

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 716 - 716, Japanese

  Meeting report


• 人工透析導入を回避しえた糖尿病性腎症3B期合併妊娠の1例

  石原 あゆみ, 松岡 正造, Deguchi Masashi, 森上 聡子, 篠崎 奈々絵, 笹川 勇樹, 山下 萌, 中島 由貴, 伊勢 由香里, 平久 進也, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 534, Japanese

  Meeting report


• 周産期の感染症 先天性サイトメガロウイルス(CMV)感染の診断における新生児血中CMV-IgM、アンチゲネミア、CMV-DNAの意義

  森岡 一朗, 平久 進也, Deguchi Masashi, 蝦名 康彦, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 450, Japanese

  Meeting report


• 産科出血等の管理 分娩後出血に対する選択的動脈塞栓術無効に関連する因子の検討

  山崎 友維, 森田 宏紀, 平久 進也, 篠崎 奈々絵, Deguchi Masashi, 松岡 正造, 宮原 義也, 蝦名 康彦, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 461, Japanese

  Meeting report


• 抗リン脂質抗体症候群母体から出生した児に胃破裂を発症した1例

  山下 萌, Deguchi Masashi, 森田 宏紀, 松岡 正造, 平久 進也, 篠崎 奈々絵, 小嶋 伸恵, 中島 由貴, 伊勢 由香里, 石原 あゆみ, 森岡 一朗, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 531, Japanese

  Meeting report


• 近年日本における母子感染の実態

  平久 進也, 森岡 一朗, 蝦名 康彦, 長又 哲史, 園山 綾子, Tanimura Kenji, Deguchi Masashi, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 684, Japanese

  Meeting report


• 急速なIgG avidity index上昇はサイトメガロウイルス先天性感染の発生予知因子である

  市橋 さなえ, 蝦名 康彦, 平久 進也, Deguchi Masashi, 森岡 一朗, Tanimura Kenji, 峰松 俊夫, 山田 秀人

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 685 - 685, Japanese

  Meeting report


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  笹川 勇樹, 蝦名 康彦, 長又 哲史, 園山 綾子, 伊勢 由香里, 森岡 一朗, 平久 進也, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, 山田 秀人

  Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 685, Japanese

  Meeting report


• HLAクラスII/β2-glycoprotein Iタンパク質複合体は抗リン脂質抗体症候群の病態に関わる主要な標的分子である

  Tanimura Kenji, Deguchi Masashi, 蝦名 康彦, 山田 秀人, 荒瀬 尚

  日本産科婦人科学会, Feb. 2014, 日本産科婦人科学会雑誌, 66(2号) (2号), 584 - 584, Japanese

  Meeting report


• P2-37-4 近年日本における母子感染の実態(Group 75 周産期の感染症2,一般演題,第66回学術講演会)

  平久 進也, 森岡 一朗, 蝦名 康彦, 長又 哲史, 園山 綾子, 谷村 憲司, 出口 雅士, 山田 秀人

  日本産科婦人科学会, 2014, 日本産科婦人科學會雜誌, 66(2) (2), 684 - 684, Japanese


• ISAC-3-4 The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study(Group 3 Perinatology,IS Award Candidate,International Session) :

  Nagamata Satoshi, Ebina Yasuhiko, Minematsu Toshio, Sonoyama Ayako, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Yamada Hideto

  日本産科婦人科学会, 2014, 日本産科婦人科學會雜誌, 66(2) (2), 920 - 920, English


• ISP-20-4 Association between protein C, protein S, factor XII, and spontaneous abortion, adverse pregnancy outcome(Group 20 Reproduction 3,IS Poster,International Session) :

  Ebina Yasuhiko, Kobashi Gen, Deguchi Masashi, Minakami Hisanori, Yamada Hideto

  日本産科婦人科学会, 2014, 日本産科婦人科學會雜誌, 66(2) (2), 973 - 973, English


• 【読み方がわかる！説明できる!産科の臨床検査ディクショナリー これさえあれば妊婦健診で困らない! エコーもCTGも】 (第4章)特別なニードがある場合の検査を理解しよう! ヒトパルボウイルスB19

  蝦名 康彦, Deguchi Masashi, Yamada Hideto

  Jan. 2014, ペリネイタルケア, (2014新春増刊) (2014新春増刊), 181 - 184, Japanese

  [Invited]

  Introduction commerce magazine


• 【読み方がわかる!説明できる！産科の臨床検査ディクショナリー これさえあれば妊婦健診で困らない! エコーもCTGも】 (第4章)特別なニードがある場合の検査を理解しよう! サイトメガロウイルス抗体

  蝦名 康彦, Deguchi Masashi, Yamada Hideto

  Jan. 2014, ペリネイタルケア, (2014新春増刊) (2014新春増刊), 176 - 180, Japanese

  [Invited]

  Introduction commerce magazine


• 【読み方がわかる!説明できる!産科の臨床検査ディクショナリー これさえあれば妊婦健診で困らない！ エコーもCTGも】 (第4章)特別なニードがある場合の検査を理解しよう! トキソプラズマ抗体

  平久 進也, Deguchi Masashi, Yamada Hideto

  Jan. 2014, ペリネイタルケア, (2014新春増刊) (2014新春増刊), 171 - 175, Japanese

  [Invited]

  Introduction commerce magazine


• 【読み方がわかる!説明できる!産科の臨床検査ディクショナリー これさえあれば妊婦健診で困らない! エコーもCTGも】 (第4章)特別なニードがある場合の検査を理解しよう! 自己抗体検査

  Deguchi Masashi, 蝦名 康彦, Yamada Hideto

  Jan. 2014, ペリネイタルケア, (2014新春増刊) (2014新春増刊), 166 - 170, Japanese

  [Invited]

  Introduction commerce magazine


• 臨床研究の成果を実地臨床へ生かそう―産科編 我が国における多施設共同研究の現状―サイトメガロウイルス―

  山田秀人, 森岡一朗, 平久進也, 谷村憲司, 出口雅士, 蝦名康彦

  10 Oct. 2013, 周産期医学, 43(10) (10), 1295 - 1299, Japanese


• 当院におけるプロテインS低下症例に関する検討

  篠崎 奈々絵, 出口 雅士, 前澤 陽子, 森田 宏紀, 山田 秀人

  Oct. 2013, 日本生殖医学会雑誌, 58(4号) (4号), 396, Japanese

  Meeting report


• 【いま知りたい!母子感染対策 トキソプラズマ,サイトメガロウイルスを中心に】 母子感染の恐れのある感染症の情報

  Yamada Hideto, 平久 進也, Morioka Ichiro, Ebina Yasuhiko, 出口 雅士, 長又 哲史

  医学書院, Jul. 2013, 助産雑誌, 67(7号) (7号), 520 - 525, Japanese

  [Invited]

  Introduction commerce magazine


• 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 サイトメガロウイルス母子感染対策のための妊婦教育効果の検討,ならびに妊婦スクリーニング体制の構築

  山田秀人, 古谷野伸, 岡明, 井上直樹, 森岡一朗, 森内浩幸, 吉川哲史, 伊藤裕司, 浅野仁覚, 五石圭司, 三牧正和, 蝦名康彦, 谷村憲司, 平久進也, 園山綾子, 出口雅士

  2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成23-24年度 総合研究報告書, 31 - 53, Japanese


• 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討,妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 サイトメガロウイルス母子感染対策のための妊婦教育効果の検討,ならびに妊婦スクリーニング体制の構築

  山田秀人, 古谷野伸, 岡明, 井上直樹, 森岡一朗, 森内浩幸, 吉川哲史, 伊藤裕司, 浅野仁覚, 三牧正和, 蝦名康彦, 平久進也, 出口雅士

  2013, 先天性サイトメガロウイルス感染症対策のための妊婦教育の効果の検討、妊婦・新生児スクリーニング体制の構築及び感染新生児の発症リスク同定に関する研究 平成24年度 総括・分担研究報告書, 29 - 47, Japanese


• K2-7-2 卵母細胞由来Interleukin 7(IL-7)はPI3K/AKT回路を介し卵巣顆粒膜細胞のアポトーシスを抑制し卵母細胞の核成熟を促進する(高得点演題7,生殖医学)

  山田 愛, 出口 雅士, JW Hsueh Aaron, 中林 幸士, 山田 秀人

  日本産科婦人科学会, 2012, 日本産科婦人科學會雜誌, 64(2) (2), 582 - 582, Japanese


• P1-10-13 子宮動脈塞栓術を施行し,手術を行った巨大子宮筋腫の2症例(Group13 良性卵巣腫瘍・症例2,一般演題,第63回日本産科婦人科学会学術講演会)

  陌間 亮一, 宮原 義也, 森田 宏紀, 武居 智信, 牧原 夏子, 鈴木 嘉穂, 出口 雅士, 中林 幸士, 蝦名 康彦, 吉田 茂樹, 山田 秀人

  日本産科婦人科学会, 2011, 日本産科婦人科學會雜誌, 63(2) (2), 499 - 499, Japanese


• P1-10-30 妊娠16週で肝右葉切除術を行った肝血管腫合併妊娠の1例(Group14 良性卵巣腫瘍・症例3,一般演題,第63回日本産科婦人科学会学術講演会)

  西本 昌司, 陌間 亮一, 武居 智信, 牧原 夏子, 鈴木 嘉穂, 出口 雅士, 中林 幸士, 宮原 義也, 蝦名 康彦, 吉田 茂樹, 山田 秀人

  日本産科婦人科学会, 2011, 日本産科婦人科學會雜誌, 63(2) (2), 504 - 504, Japanese


• P3-133 卵巣腫瘍手術症例における下肢静脈血栓症術前診断の検討(Group115 婦人科腫瘍血栓症1,一般演題,第62回日本産科婦人科学会学術講演会)

  武居 智信, 竹村 直也, 松岡 左希子, 鈴木 嘉穂, 陌間 亮一, 出口 雅士, 中林 幸士, 森田 宏紀, 吉田 茂樹, 小原 範之, 山田 秀人

  日本産科婦人科学会, 2010, 日本産科婦人科學會雜誌, 62(2) (2), 668 - 668, Japanese


• P2-262 子宮体部原発の小細胞未分化癌の1例(Group76 子宮体部悪性腫瘍8,一般演題,第62回日本産科婦人科学会学術講演会)

  鈴木 嘉穂, 中林 幸士, 武居 智信, 松岡 左希子, 陌間 亮一, 竹村 直也, 出口 雅士, 森田 宏紀, 吉田 茂樹, 山田 秀人

  日本産科婦人科学会, 2010, 日本産科婦人科學會雜誌, 62(2) (2), 552 - 552, Japanese


• P2-263 子宮体部Large cell neuroendocrine carcinoma(LCNEC)の一例(Group76 子宮体部悪性腫瘍8,一般演題,第62回日本産科婦人科学会学術講演会)

  園山 綾子, 出口 雅士, 竹村 直也, 中林 幸士, 森田 宏紀, 吉田 茂樹, 山田 秀人

  日本産科婦人科学会, 2010, 日本産科婦人科學會雜誌, 62(2) (2), 552 - 552, Japanese


• Uterine Artery Embolization for Obstetrical Hemorrhage

  山崎 友雄, 森田 宏紀, 白川 得朗, 吉田 奈央, 牧原 夏子, 鈴木 嘉穂, 天野 真理子, 森本 規之, 森実 真由美, 出口 雅士, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会, 2010, 日本周産期・新生児医学会雑誌, 46(2) (2), 370 - 370, Japanese

  Link to Kobe Univ. Repository (Kernel)


• Pregnancy outcome in patients with systemic lupus erythematosus

  天野 真理子, 牧原 夏子, 園山 綾子, 鈴木 嘉穂, 森本 規之, 森実 真由美, 出口 雅士, 森田 宏紀, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会, 2010, 日本周産期・新生児医学会雑誌, 46(2) (2), 472 - 472, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 先天性アンチトロンビンIII欠乏症合併妊娠9例の検討

  森実 真由美, 武居 智信, 鈴木 嘉穂, 牧原 夏子, 天野 真理子, 森本 規之, 出口 雅士, 森田 宏紀, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会, 2010, 日本周産期・新生児医学会雑誌, 46(2) (2), 476 - 476, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 新しい作用機序をもつ抗癌剤投与時の制吐剤について

  Deguchi Masashi

  May 2008, 産婦人科の進歩, 60巻, 2号, pp. 161-161, Japanese

  Introduction scientific journal


• 【女性診療科外来プラクティス】 腫瘍外来 腫瘍外来の検査 CT

  DEGUCHI MASASHI, MARUO TAKESHI

  医学書院, Apr. 2006, 臨床婦人科産科, 60巻, 4号, pp. 389-395(4) (4), 397 - 401, Japanese

  Introduction scientific journal


• Uterine artery embolization for obstetrical hemorrhage

  SUZUKI Kaho, MORITA Hiroki, SAIDA Yuki, IKUHASHI Yoshiyuki, MORIKAWA Akira, ICHIDA Kotaro, DEGUCHI Masashi, KITAO Keisuke, OHARA Noriyuki, MARUO Takeshi

  THE OBSTETRICAL GYNECOLOGICAL SOCIETY OF KINKI DISTRICT JAPAN, 2006, ADVANCES IN OBSTETRICS AND GYNECOLOGY, 58巻, 2号, pp. 225-228(2) (2), 225 - 228, Japanese


• A case of postirradiation vaginal angiosarcoma treated with recombinant interleukin-2 therapy

  K Takeuchi, M Deguchi, S Hamana, S Motoyama, S Kitazawa, T Maruo

  Nov. 2005, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 15(6) (6), 1163 - 1165, English

  [Refereed]

  Introduction scientific journal


• Pregnancy complicated with pulmonary lymphangioleiomyomatosis: Case report

  M. Fujimoto, N. Ohara, H. Sasaki, T. Funakoshi, H. Morita, M. Deguchi, T. Maruo

  2005, Clinical and Experimental Obstetrics and Gynecology, 32(3) (3), 199 - 200, English

  [Refereed]

  Introduction scientific journal


• Adenofibromasarcoma originating from a mural nodule of ovarian serous cystadenoma

  K Takeuchi, S Kitazawa, M Deguchi, T Maruo

  2005, EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 26(5) (5), 511 - 513, English

  [Refereed]

  Introduction scientific journal


• 6-24.Tumor Necrosis Factor α-1031T/C promoter polymorphism is associated with an increased risk of endometriosis in a Japanese population.(Session 7 Reproduction 1) :

  Asghari Tasneem, Yoshida Shigeki, Omori Shinya, Morizane Mayumi, Deguchi Masashi, Wang Zhuo, Kennedy Stephen, Maruo Takeshi

  日本産科婦人科学会, 2004, 日本産科婦人科學會雜誌, 56(2) (2), 404 - 404, English


• 6-23.Polymorphisms in Estrogen Receptor β Gene but not Estrogen Receptor α Gene Affect the Risk of Developing Endometriosis in a Japanese Population(Session 7 Reproduction 1) :

  Wang Zhuo, Yoshida Shigeki, Omori Shinya, Morizane Mayumi, Deguchi Masashi, Kennedy Stephen, Maruo Takeshi

  日本産科婦人科学会, 2004, 日本産科婦人科學會雜誌, 56(2) (2), 403 - 403, English


• イレウス合併妊娠4症例の臨床的検討--その診断と治療方針に関する考察

  大木 規義, 武内 享介, 出口 雅士

  東京医学社, Mar. 2003, 周産期医学, 33(3) (3), 405 - 408, Japanese


• ゴナドトロピン非依存性思春期早発症で発症し,経過中に性中枢の早熟が誘発された甲状腺機能低下症の1例

  八木麻理子, 竹島泰弘, 出口雅士, 歳内亨介, 松尾雅文, 中村肇

  01 Mar. 2003, 日本小児科学会雑誌, 107(3) (3), 574, Japanese


• 子宮頸部扁平上皮細胞の癌化における活性型Notch 1発現の検討(第6群 子宮頸部悪性腫瘍6)

  出口 雅士, 濱名 伸也, 森山 俊武, 吉田 茂樹, 本山 覚, 丸尾 猛

  日本産科婦人科学会, 2003, 日本産科婦人科學會雜誌, 55(2) (2), 182 - 182, Japanese


• 35 進行子宮頚癌に対する高用量経皮的骨盤灌流化学療法の有効性

  濱名 伸也, 宮原 義也, 出口 雅士, 立岩 洋一, 武木田 茂樹, 山辺 晋吾, 本山 覚, 丸尾 猛

  日本産科婦人科学会, 2002, 日本産科婦人科學會雜誌, 54(2) (2), 254 - 254, Japanese

• 実践臨床生殖免疫学 / 大量免疫グロブリン

  Yamada Hideto, Deguchi Masashi

  Others, 中外医学社, 2018, Japanese

  Scholarly book


• 実践臨床生殖免疫学 / 凝固異常（血栓性素因）

  Deguchi Masashi, Yamada Hideto

  Others, 中外医学社, 2018, Japanese

  Scholarly book


• 産婦人科感染症マニュアル / インフルエンザ

  Deguchi Masashi, Yamada Hideto

  Others, 金原出版, 2018, Japanese

  Scholarly book


• 産婦人科研修の必修知識2016~2018 / 常位胎盤早期剥離

  Deguchi Masashi, 山田秀人

  Others, 日本産科婦人科学会, 2016, Japanese

  Scholarly book


• 抗リン脂質抗体症候群合併妊娠 診療ガイドライン / CQ3 産科的 APS のリスクにあった治療方法は ?

  Deguchi Masashi, 山田秀人, 金子佳代子, 後藤美賀子, 村島温子

  Others, 南山堂, 2016, Japanese

  Scholarly book


• 抗リン脂質抗体症候群合併妊娠 診療ガイドライン / CQ2 産科的APSのリスクの評価方法は ?

  Deguchi Masashi, 山田秀人, 金子佳代子, 後藤美賀子, 村島温子

  Others, 南山堂, 2016, Japanese

  Scholarly book


• 止血・血栓ハンドブック / 抗リン脂質抗体症候群と妊娠・分娩

  Deguchi Masashi, 谷村憲司, 山田秀人

  Others, 西村書店, 2015, Japanese

  Scholarly book

• 先天性サイトメガロウイルス感染発生に関連する臨床・検査所見

  YAMADA HIDETO, 内田 明子, DEGUCHI MASASHI, TANIMURA KENJI

  AMED 成育疾患克服等総合研究事業「母子感染に対する母子保健体制構築と医療開発技術のための研究」平成30年度第2回班会議, Dec. 2018, Japanese, 東京, Domestic conference

  Others


• 不育症リスク因子としてのネオ・セルフ抗体

  TANIMURA KENJI, 齋藤 滋, 中塚 幹也, 永松 健, 藤井 知行, SASAGAWA YUUKI, DEGUCHI MASASHI, EBINA YASUHIKO, 荒瀬 規子, 荒瀬 尚, YAMADA HIDETO

  第33回日本生殖免疫学会総会・学術集会, Nov. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 妊娠初期のプロテインS低値と産科異常との関連

  DEGUCHI MASASHI, TANIMURA KENJI, EBINA YASUHIKO, YAMADA HIDETO

  第33回日本生殖免疫学会総会・学術集会, Nov. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 分娩後出血に対するUAEの帰結およびUAE後の妊娠についての検討

  IMAFUKU HITOMI, MORIZANE MAYUMI, TANIMURA KENJI, DEGUCHI MASASHI, YAMADA HIDETO

  第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference

  Poster presentation


• 不育症診療の現状と課題～さらなる妊娠予後改善にむけて～

  DEGUCHI MASASHI, YAMADA HIDETO

  第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference

  Invited oral presentation


• 妊婦抗体スクリーニングおよび臨床所見による先天性サイトメガロウイルス感染の発生予知

  内田 明子, TANIMURA KENJI, 平久 進也, 尾崎 可奈, NAGAMATA SATOSHI, MORIZANE MAYUMI, DEGUCHI MASASHI, EBINA YASUHIKO, MORIOKA ICHIRO, 峰松 俊夫, YAMADA HIDETO

  第45回日本産婦人科医会学術集会, Oct. 2018, Japanese, 大阪, Domestic conference

  Poster presentation


• 神戸大学における不育症の臨床因子と妊娠予後の検討

  宮地 真帆, DEGUCHI MASASHI, IMAFUKU HITOMI, TANIMURA KENJI, MORIZANE MAYUMI, EBINA YASUHIKO, YAMADA HIDETO

  第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference

  Poster presentation


• 子宮頸部上皮内新生物(CIN)合併妊娠における保存的管理に関する検討

  木原 智子, DEGUCHI MASASHI, EBINA YASUHIKO, UENAKA MIZUKI, SUZUKI KAHO, MIYAHARA YOSHIYA, YAMADA HIDETO

  第59回日本母性衛生学会総会・学術集会, Oct. 2018, Japanese, 新潟, Domestic conference

  Oral presentation


• 不育症のトピックス～不育症とネオ・セルフ

  TANIMURA KENJI, SASAGAWA YUUKI, IMAFUKU HITOMI, MORIZANE MAYUMI, DEGUCHI MASASHI, EBINA YASUHIKO, 荒瀬 規子, 荒瀬 尚, 齋藤 滋, YAMADA HIDETO

  第63回日本生殖医学会学術講演会・総会, Sep. 2018, Japanese, 旭川, Domestic conference

  Nominated symposium


• Pregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhage

  Mayumi Morizane, Hitomi Imafuku, SHIRAKAWA TOKURO, Kenji Tanimura, Masashi Deguchi, Hideto Yamada

  The 20th congress of federation of asia oceania perinatal societies (FAOPS), Sep. 2018, English, Manila, International conference

  Poster presentation


• Placental pathology of congenital cytomegalovirus infection

  Mizuki Uenaka, Mayumi Morizane, Kenji Tanimura, Masashi Deguchi, Kanzawa Maki, Hideto Yamada

  International federation of placenta associations (IFPA) 2018 Tokyo, Sep. 2018, English, Tokyo, International conference

  Poster presentation


• 卵巣境界悪性腫瘍治療後にPET/CTで傍大動脈リンパ節転移を疑った傍神経節腫の１例

  松本 培世, EBINA YASUHIKO, 安積 真帆, SUZUKI KAHO, WAKAHASHI SENN, MIYAHARA YOSHIYA, DEGUCHI MASASHI, 上野 嘉子, 田中宇多留, 村上 卓道, 小松 正人, 神澤 真紀, 伊藤 智雄, YAMADA HIDETO

  第19回JSAWI, Aug. 2018, Japanese, 淡路, Domestic conference

  Poster presentation


• 卵巣癌患者における治療前Prognostic nutritional indexと予後

  EBINA YASUHIKO, NAGAMATA SATOSHI, SUZUKI KAHO, WAKAHASHI SENN, MIYAHARA YOSHIYA, DEGUCHI MASASHI, YAMADA HIDETO

  第42回日本産科婦人科栄養・代謝研究会, Aug. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例

  鷲尾 佳一, UENAKA MIZUKI, TANIMURA KENJI, SHIRAKAWA TOKURO, MORIZANE MAYUMI, DEGUCHI MASASHI, YAMADA HIDETO

  第42回日本産科婦人科栄養・代謝研究会, Aug. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 胎児甲状腺腫を来たしたT3優位型バセドウ病合併妊娠の2例

  鷲尾 佳一, UENAKA MIZUKI, TANIMURA KENJI, SHIRAKAWA TOKURO, MORIZANE MAYUMI, DEGUCHI MASASHI, YAMADA HIDETO

  第41回日本母体胎児医学会学術集会, Aug. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• メトホルミンが著効したインスリン抵抗症合併妊娠の1例

  UENAKA MIZUKI, 鷲尾 佳一, DEGUCHI MASASHI, TANIMURA KENJI, MORIZANE MAYUMI, YAMADA HIDETO

  第42回日本産科婦人科栄養・代謝研究会, Aug. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 妊婦のB型肝炎スクリーニングと垂直感染予防

  SASAGAWA YUUKI, TANIMURA KENJI, 山名 哲司, MORIZANE MAYUMI, DEGUCHI MASASHI, MORIOKA ICHIRO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 尿サイトメガロウイルス（CMV）スクリーニングで同定した先天性CMV感染児の前方視的観察研究

  福嶋 祥代, 森岡 一朗, 芦名 満理子, 生田 寿彦, 大山 正平, 大久保 沙紀, 山名 啓司, FUJIOKA KAZUMICHI, MORIZANE MAYUMI, DEGUCHI MASASHI, TANIMURA KENJI, 船越 徹, 大橋 正伸, IIJIMA KAZUMOTO, YAMADA HIDETO

  第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference

  Oral presentation


• 当院不育症外来における不育症リスク因子と治療成績

  SHIRAKAWA TOKURO, DEGUCHI MASASHI, 宮地 真帆, MORIZANE MAYUMI, TANIMURA KENJI, EBINA YASUHIKO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• 当院における先天性トキソプラズマ感染症の発生に関する臨床前向き研究

  大山 正平, 森岡 一朗, 福嶋 祥代, 芦名 満理子, 生田 寿彦, 大久保 沙紀, 山名 啓司, FUJIOKA KAZUMICHI, MORIZANE MAYUMI, DEGUCHI MASASHI, TANIMURA KENJI, IIJIMA KAZUMOTO, YAMADA HIDETO

  第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference

  Oral presentation


• 胎児発育不全児の予後不良に関連する因子の検討

  吉澤ひかり, TANIMURA KENJI, 内山美穂子, 白國あかり, MORIZANE MAYUMI, DEGUCHI MASASHI, FUJIOKA KAZUMICHI, MORIOKA ICHIRO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 先天性サイトメガロウイルス感染の胎盤病理

  UENAKA MIZUKI, MORIZANE MAYUMI, TANIMURA KENJI, DEGUCHI MASASHI, MORIOKA ICHIRO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 進行卵巣・腹膜癌における腹水セルブロック法による免疫組織化学の検討

  安積 麻帆, EBINA YASUHIKO, SUZUKI KAHO, WAKAHASHI SENN, MIYAHARA YOSHIYA, DEGUCHI MASASHI, YAMADA HIDETO

  第92回兵庫県産婦人科学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 症候性先天性CMV感染児の1歳6か月時点でのDQ＜70と関連する新生児期リスク因子の後方視的検討

  福嶋 祥代, 森岡 一朗, 芦名 満理子, 生田 寿彦, 大山 正平, 大久保 沙紀, 山名 啓司, FUJIOKA KAZUMICHI, MORIZANE MAYUMI, DEGUCHI MASASHI, TANIMURA KENJI, IIJIMA KAZUMOTO, YAMADA HIDETO

  第 54 回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京都, Domestic conference

  Oral presentation


• 症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療

  TANIMURA KENJI, 内田 明子, IMAFUKU HITOMI, MORIZANE MAYUMI, DEGUCHI MASASHI, FUJIOKA KAZUMICHI, MORIOKA ICHIRO, 峰松 俊夫, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 抗β2GPI/HLA-DR抗体と不育、産科異常との関連解明と治療指針の確立

  TANIMURA KENJI, DEGUCHI MASASHI, 齋藤 滋, YAMADA HIDETO

  AMED成育疾患克服等次世代育成基盤研究事業「不育症の原因解明、予防治療に関する研究」平成30年度 第1回班会議, Jul. 2018, Japanese, 東京, Domestic conference

  Others


• 維持透析療法を要した腎不全合併妊娠3例

  黒島 瑞穂, TANIMURA KENJI, SASAGAWA YUUKI, SHIRAKAWA TOKURO, IMAFUKU HITOMI, MORIZANE MAYUMI, DEGUCHI MASASHI, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• トキソプラズマ妊婦スクリーニングの前向きコホート研究

  内田 明子, TANIMURA KENJI, 西川 鑑, 里吉 雅恵, 清水亜由美, 施 裕徳, 田中恵里加, MORIZANE MAYUMI, DEGUCHI MASASHI, EBINA YASUHIKO, MORIOKA ICHIRO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• トキソプラズマ抗体妊婦スクリーニングの前向きコホート研究

  内田 明子, TANIMURA KENJI, 西川 鑑, 清水亜由美, 施 裕徳, 田中恵里加, MORIZANE MAYUMI, DEGUCHI MASASHI, EBINA YASUHIKO, MORIOKA ICHIRO, YAMADA HIDETO

  第54回日本周産期・新生児医学会学術集会, Jul. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• CIN2患者に対するレーザー蒸散術の検討（第二報）

  EBINA YASUHIKO, UENAKA MIZUKI, IMAFUKU HITOMI, NAGAMATA SATOSHI, SUZUKI KAHO, MIYAHARA YOSHIYA, DEGUCHI MASASHI, YAMADA HIDETO

  第92回兵庫県産婦人科学会学術集会, Jul. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 妊婦のB型肝炎スクリーニングと垂直感染予防

  SASAGAWA YUUKI, TANIMURA KENJI, 山名 哲司, MORIZANE MAYUMI, DEGUCHI MASASHI, MORIOKA ICHIRO, YAMADA HIDETO

  第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• 子宮頚部上皮内新生物（CIN）合併妊娠における保存的管理に関する検討

  白國あかり, EBINA YASUHIKO, IMAFUKU HITOMI, NAGAMATA SATOSHI, UENAKA MIZUKI, SUZUKI KAHO, WAKAHASHI SENN, MIYAHARA YOSHIYA, DEGUCHI MASASHI, YAMADA HIDETO

  第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• トラベクテジンにより長期間病勢コントロールを行った平滑筋肉腫の一例

  NAGAMATA SATOSHI, EBINA YASUHIKO, SUZUKI KAHO, WAKAHASHI SENN, MIYAHARA YOSHIYA, DEGUCHI MASASHI, YAMADA HIDETO

  第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• PPAPスコアリングシステムを用いた前置胎盤の管理

  TANIMURA KENJI, MORIZANE MAYUMI, DEGUCHI MASASHI, 上野 嘉子, YAMADA HIDETO

  第138回近畿産科婦人科学会総会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• Autoantibodies against β2-glycoprotein I/HLA class II complexes in women with recurrent pregnancy loss

  Kenji Tanimura, Masashi Deguchi, Yasuhiko Ebina, Arase Nao, Saito Shigeru, Arase Hisashi, Hideto Yamada

  The 38th annual meeting of the american sciety for reproductive immunology, Jun. 2018, English, Shanghai, International conference

  Oral presentation


• 症候性の先天性サイトメガロウイルス感染症に対する胎児治療と新生児治療の有効性

  TANIMURA KENJI, 内田 明子, IMAFUKU HITOMI, MORIZANE MAYUMI, DEGUCHI MASASHI, FUJIOKA KAZUMICHI, MORIOKA ICHIRO, 峰松 俊夫, YAMADA HIDETO

  第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conference

  Oral presentation


• トキソプラズマ抗体妊婦スクリーニングに関する前向きコホート研究

  内田 明子, TANIMURA KENJI, 西川 鑑, 清水亜由美, 施 裕徳, 田中恵里加, MORIZANE MAYUMI, DEGUCHI MASASHI, EBINA YASUHIKO, MORIOKA ICHIRO, YAMADA HIDETO

  第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conference

  Oral presentation


• Three cases of complete hydatidiform mole coexistent with a live twin fetus

  Hikari Yoshizawa, Yasuhiko Ebina, Hitomi Imafuku, Kaho Suzuki, Senn Wakahashi, Yoshiya Miyahara, Masashi Deguchi, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• The distribution of etiology and therapy outcomes of recurrent pregnancy loss at our recurrent pregnancy loss clinic

  Maho Miyaji, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Yasuhiko Ebina, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• Risk factors for congenital cytomegalovirus infection in pregnant women with non-primary infection

  Akiko Uchida, Kenji Tanimura, Shinya Tairaku, Kana Ozaki, Satoshi Nagamata, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Morioka I, Toshio Minematsu, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Others


• Prenatal genetic diagnosis for neonatal alloimmune thrombocytepenia for women with the history of neonatal alloimmune thrombocytopenia

  Akari Shirakuni, Masashi Deguchi, Maho Miyaji, Yutoku Shi, Akiko Uchida, Sanae Ichihashi, Nasashi Nishimoto, Tokuro Shirakawa, Kenji Tanimura, Mayumi Morizane, Ichiro Morioka, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• Pregnancy outcomes subsequent to uterine arterial embolization for severe post-partum hemorrhage

  Hitomi Imafuku, Mayumi Morizane, Tokuro Shirakawa, Kenji Tanimura, Masashi Deguchi, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• Immunoglobulin fetal therapy for symptomatic congenital cytomegalovirus infection

  Yutoku Shi, Kenji Tanimura, Akiko Uchida, Mizuki Uenaka, Mayumi Morizane, Masashi Deguchi, Yasuhiko Ebina, Ichiro Morioka, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• HBV妊婦スクリーニングと母子感染予防の前向き研究

  SASAGAWA YUUKI, TANIMURA KENJI, 山名 哲司, MORIZANE MAYUMI, DEGUCHI MASASHI, MORIOKA ICHIRO, YAMADA HIDETO

  第35回日本産婦人科感染症学会学術集会, May 2018, Japanese, 岐阜, Domestic conference

  Oral presentation


• Efficacy of maternal screening and perinatal prevention program for hepatitis B

  Tokuro Shirakawa, SASAGAWA YUUKI, Masashi Deguchi, Kenji Tanimura, Mayumi Morizane, Morioka Ichiro, Hideto Yamada

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Public symposium


• DomainV of β2GPI has very high affinity with MHC class II

  Yuki Sasagawa, Kenji Tanimura, Satoko Morikami, Masashi Deguchi, Yasuhiko Ebina, Hideto Yamada, Arase Hisashi

  第70回日本産科婦人科学会学術講演会, May 2018, English, 仙台, Domestic conference

  Poster presentation


• CKD4Tで挙児に至ったIgA腎症の一例

  泉博子, Fujii Hideki, Goto Shunsuke, 高橋良輔, Deguchi Masashi, 小川悟志, Ishimura Takeshi, Fujisawa Masato, Yamada Hideto, Nishi Shinichi

  第51回 日本臨床腎移植学会, Feb. 2018, Japanese, 日本臨床腎移植学会, Kobe, 神戸, Domestic conference

  Poster presentation


• 先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果

  Morioka Ichiro, 大山正平, 福嶋祥代, Nishida Kosuke, Yamana Keiji, Iijima Kazumoto, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference

  Oral presentation


• 抗ウイルス薬治療を行った症候性先天性サイトメガロウイルス感染児の1歳6か月時の神経学的予後評価と予後不良因子の検討

  Morioka Ichiro, 福嶋祥代, 大山正平, Nishida Kosuke, Yamana Keiji, Iijima Kazumoto, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference

  Oral presentation


• トキソプラズマ妊婦スクリーニングの前向きコホート研究

  施 裕徳, Deguchi Masashi, 西川 鑑, 清水亜由美, Tanimura Kenji, 内田明子, 田中恵理加, Morizane Mayumi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference

  Oral presentation


• サイトメガロウイルス

  Tanimura Kenji, Ebina Yasuhiko, Deguchi Masashi, Morizane Mayumi, Morioka Ichiro, 峰松俊夫, Yamada Hideto

  第32回日本生殖免疫学会総会・学術集会, Dec. 2017, Japanese, 日本生殖免疫学会, 東京, Domestic conference

  [Invited]

  Nominated symposium


• 妊娠中にネフローゼ症候群を発症し、ステロイドおよび血漿交換にて完全寛解に至った一例

  小嶋 真理子, Goto Shunsuke, 泉 博子, 内田 朋子, Deguchi Masashi, Fujii Hideki, Yamada Hideto, Nishi Shinichi

  第47回 日本腎臓学会西部学術大会, Oct. 2017, Japanese, 日本腎臓学会, Okayama, 岡山, Domestic conference

  Oral presentation


• 不育症 体のケアと心のケア 治療抵抗性、難治性の習慣流産に対する治療

  Deguchi Masashi

  母性衛生, Sep. 2017, Japanese

  [Invited]

  Oral presentation


• 先天性CMV感染児の出生体重と神経学的予後に関する検討

  Nishida Kosuke, Morioka Ichiro, 大山正平, 福嶋祥代, Yamana Keiji, 黒川大輔, 岩谷壮太, Iijima Kazumoto, Deguchi Masashi, Tanimura Kenji, Yamada Hideto

  第53回日本周産期・新生児医学会学術集会, Jul. 2017, Japanese, 日本周産期・新生児医学会, 横浜, Domestic conference

  Oral presentation


• 胎児腹水を呈した症候性先天性サイトメガロウイルス感染症3例の出生後の臨床経過

  Nishida Kosuke, Morioka Ichiro, Deguchi Masashi, Tanimura Kenji, 平久進也, Ebina Yasuhiko, Yamada Hideto

  第69回日本産科婦人科学会学術集会, May 2017, Japanese, 日本産婦人科学会, 広島, Domestic conference

  Poster presentation


• 持続血糖モニターを用いた妊娠糖尿病患者における分娩中の血糖動態の検討

  黒飛 友里, 村前 直和, Okada Yuko, 山田 倫子, 中村 友昭, Fukuoka Hidenori, Hirota Yushi, Sakaguchi Kazuhiko, Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Yamada Hideto, Ogawa Wataru

  第60回日本糖尿病学会年次学術集会, May 2017, Japanese, 日本糖尿病学会, 名古屋, Domestic conference

  Poster presentation


• トキソプラズマ妊婦スクリーニングの前向き研究

  田中恵里加, Tanimura Kenji, 高橋良輔, 平久進也, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, 清水亜由美, 西川 鑑, Yamada Hideto

  第34回日本産婦人科感染症学会, May 2017, Japanese, 日本産婦人科感染症学会, 奈良, Domestic conference

  Oral presentation


• Two cases of prenatal genetic diagnosis for neonatal alloimmune thrombocytopenia for women with the history of neonatal alloimmune thrombocytopenia in the prior pregnancy

  Deguchi Masashi, Tanimura Kenji, Uenaka M, Morizane Mayumi, Morioka Ichiro, Yamada Hideto

  21st International Conference on Prenatal Diagnosis and Therapy, May 2017, English, International Society for Prenatal Diagnosis, San Diego, USA, International conference

  Poster presentation


• Noninvasive methods for predicting congenital cytomegalovirus infection in high-risk pregnant women

  Tanimura Kenji, Tairaku S, Ebina Yasuhiko, Morioka Ichiro, Nagamata S, Ozaki K, Morizane Mayumi, Deguchi Masashi, Minematsu T, Yamada Hideto

  21st International Conference on Prenatal Diagnosis and Therapy, May 2017, English, International Society for Prenatal Diagnosis, San Diego, USA, International conference

  Poster presentation


• Efficacy of maternal serological screening for congenital cytomegalovirus infection

  Tairaku S, Tanimura Kenji, Morioka Ichiro, Ozaki K, Nagamata S, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Minematsu T, Yamada Hideto

  第69回日本産科婦人科学会学術集会, May 2017, Japanese, 日本産婦人科学会, 広島, Domestic conference

  Poster presentation


• 妊婦のサイトメガロウイルス抗体スクリーニングの有用性

  Tairaku Shinya, Tanimura Kenji, Morioka Ichiro, 尾崎可奈, 長又哲史, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, 峰松俊夫, Yamada Hideto

  第31回日本生殖免疫学会, Dec. 2016, Japanese, 日本生殖免疫学会, 神戸, Domestic conference

  Oral presentation


• インスリン使用/非使用GDM症例におけるインスリン分泌能・感受性指標の比較

  平野靖子, 村前直和, 高橋陸, 山田倫子, 中村友昭, Fukuoka Hidenori, Okada Yuko, Hirota Yushi, Sakaguchi Kazuhiko, Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Yamada Hideto, Ogawa Wataru

  第32回日本糖尿病・妊娠学会学術集会, Dec. 2016, Japanese, 日本糖尿病・妊娠学会, 岡山, Domestic conference

  Oral presentation


• インスリン使用/非使用GDM症例における インスリン分泌能・感受性指標の比較

  平野 靖子, 三浦 洋, 村前 直和, 高橋 陸, 山田 倫子, 中村 友昭, Fukuoka Hidenori, Okada Yuko, Hirota Yushi, Sakaguchi Kazuhiko, Morizane Mayumi, Deguchi Masashi, Yamada Hideto, Ogawa Wataru

  第32回日本糖尿病・妊娠学会年次学術集会, Nov. 2016, Japanese, 日本糖尿病・妊娠学会, 岡山, Domestic conference

  Oral presentation


• 胎児甲状腺機能亢進症を来たしたT3優位型バセドウ病合併妊娠の1例

  上中美月, Deguchi Masashi, 豊永絢香, 小嶋伸恵, Tairaku Shinya, 篠崎奈々絵, Morizane Mayumi, Tanimura Kenji, Nishida Kosuke, Morioka Ichiro, Yamada Hideto

  第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conference

  Poster presentation


• 新生児同種免疫性血小板減少症の3例

  内山美穂子, Deguchi Masashi, Tairaku Shinya, Morimoto Noriyuki, Morizane Mayumi, Tanimura Kenji, 香田 翼, Morioka Ichiro, Yamada Hideto

  第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conference

  Poster presentation


• シンポジウム：本邦におけるパルボウイルスB19母子感染の実態

  Ebina Yasuhiko, Tairaku Shinya, Morioka Ichiro, Deguchi Masashi, Tanimura Kenji, Morizane Mayumi, Yamada Hideto

  第52回日本周産期・新生児医学会学術集会, Jul. 2016, Japanese, 日本周産期・新生児医学会, 富山, Domestic conference

  [Invited]

  Nominated symposium


• Mycoplasma hominisisによる子宮内感染から新生児遷延性肺高血圧症を呈した早産児の1例

  Morioka Ichiro, Fujita Kaori, Iwatani Souta, 出口可奈, Tanimura Kenji, Deguchi Masashi, Iijima Kazumoto, Yamada Hideto

  第33回日本産婦人科感染症学会学術集会, Jul. 2016, Japanese, 日本産婦人科感染症学会, 東京, Domestic conference

  Oral presentation


• IgG avidity とPCR 法を用いたサイトメガロウイルス妊婦スクリーニング

  Tairaku Shinya, Tanimura Kenji, Morioka Ichiro, 出口可奈, 長又哲史, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, 峰松俊夫, Yamada Hideto

  第34回日本産婦人科感染症学会学術集会, Jul. 2016, Japanese, 日本産婦人科感染症学会, 東京, Domestic conference

  Oral presentation


• 胎児甲状腺機能亢進症を来たしたTRAb著明高値バセドウ病合併妊娠の一例

  上中美月, Deguchi Masashi, 豊永絢香, 小嶋伸恵, Tairaku Shinya, 篠崎奈々絵, Morizane Mayumi, Tanimura Kenji, Nishida Kosuke, Morioka Ichiro, 吉田健一, Takahashi Yutaka, Yamada Hideto

  第134回近畿産科婦人科学会, Jun. 2016, Japanese, 近畿産科婦人科学会, 京都, Domestic conference

  Oral presentation


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  Tairaku Shinya, Tanimura Kenji, Morioka Ichiro, 長又哲史, Deguchi Masashi, Ebina Yasuhiko, 峰松俊夫, Yamada Hideto

  第134回近畿産科婦人科学会, Jun. 2016, Japanese, 近畿産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 先天性サイトメガロウイルス感染症児における生後早期の頭部MRI所見

  Nishida Kosuke, Morioka Ichiro, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, Ebina Yasuhiko, Yamada Hideto

  第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 新生児同種免疫性血小板減少症の2例：過去の妊娠で児が新生児同種免疫性血小板減少症を発症した女性の周産期管理

  上中美月, Morizane Mayumi, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, Morioka Ichiro, Yamada Hideto

  第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• The effect of maternal screening for HBV and perinatal HBV prevention program

  Yuki Sasagawa, Deguchi Masashi, Akiko Takeda, Tanimura Kenji, Morizane Mayumi, Morioka Ichiro, Yamada Hideto

  第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• Maternal blood screening for congenital cytomegalovirus infection of the infants

  Tairaku Shinya, Tanimura Kenji, Morioka Ichiro, Satoshi Nagamata, Deguchi Masashi, Ebina Yasuhiko, Toshio Minematsu, Yamada Hideto

  第68回日本産科婦人科学会, Apr. 2016, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 「母児の予後からみた娩出のタイミングと方法」、癒着胎盤予測スコアを用いた前置胎盤の手術管理

  Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第34回周産期学シンポジウム, Feb. 2016, Japanese, 日本周産期新生児医学会, 神戸, Domestic conference

  Public symposium


• 先天性アンチトロンビン欠乏症合併妊婦における遺伝子解析結果と臨床像の検討

  Ebina Yasuhiko, 中町 祐司, Tanimura Kenji, Morizane Mayumi, Tairaku Shinya, Deguchi Masashi, Kawano Seiji, Yamada Hideto

  第1回産婦人科遺伝診療学会, Dec. 2015, Japanese, 産婦人科遺伝診療学会, 長崎, Domestic conference

  Oral presentation


• 糖代謝異常合併妊娠における 必要インスリンの増加量および関連因子の検討

  山田 倫子, 岡田 裕子, 浦井 伸, 伊藤 潤, 佐藤 洋幸, 細川 友誠, 竹内 健人, 三浦 洋, Hirota Yushi, Sakaguchi Kazuhiko, 小嶋 伸恵, Tanimura Kenji, Deguchi Masashi, Yamada Hideto, Ogawa Wataru

  第31回日本糖尿病・妊娠学会年次学術集会, Nov. 2015, Japanese, 日本糖尿病・妊娠学会, 東京, Domestic conference

  Oral presentation


• 1型糖尿病合併妊娠患者における 産後の血糖コントロールに 関する検討

  浦井 伸, 岡田 裕子, 山田 倫子, 伊藤 潤, 佐藤 洋幸, 細川 友誠, 竹内 健人, 三浦 洋, Hirota Yushi, Sakaguchi Kazuhiko, 小嶋 伸恵, Tanimura Kenji, Deguchi Masashi, Yamada Hideto, Ogawa Wataru

  第31回日本糖尿病・妊娠学会年次学術集会, Nov. 2015, Japanese, 日本糖尿病・妊娠学会, 東京, Domestic conference

  Oral presentation


• 妊娠中に急性増悪を来したＢ型肝炎ウイルスキャリア妊婦の2例

  大原雅代, Tanimura Kenji, 笹川勇樹, Tairaku Shinya, Maesawa Yoko, Morizane Mayumi, Deguchi Masashi, Morioka Ichiro, Yamada Hideto

  第38回日本母体胎児医学会, Oct. 2015, Japanese, 日本母体胎児医学会, 別府, Domestic conference

  Oral presentation


• 新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率

  西田浩輔, Morioka Ichiro, Koda Tsubasa, Nagasaka Miwako, Iwatani Souta, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, 船越 徹, 大橋正伸, Iijima Kazumoto, Yamada Hideto

  第51回日本周産期・新生児医学会総会学術集会, Jul. 2015, Japanese, 日本周産期・新生児医学会, 福岡, Domestic conference

  Oral presentation


• 新生児尿スクリーニングと抗ウイルス薬治療導入後の症候性先天性サイトメガロウイルス感染児の後遺症発生率

  Morioka Ichiro, 西田浩輔, Koda Tsubasa, Iwatani Souta, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, Ebina Yasuhiko, 船越 徹, 大橋正伸, Iijima Kazumoto, Yamada Hideto

  第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference

  Oral presentation


• 症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果と問題点

  Morioka Ichiro, 西田浩輔, Koda Tsubasa, Iwatani Souta, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, Ebina Yasuhiko, Iijima Kazumoto, Yamada Hideto

  第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference

  Oral presentation


• サイトメガロウイルス胎児感染の母体IgG avidity indexは急速に上昇する

  Ebina Yasuhiko, Deguchi Masashi, 峰松俊夫, Tairaku Shinya, Tanimura Kenji, 出口可奈, 山野由美香, Morizane Mayumi, Morioka Ichiro, Yamada Hideto

  第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference

  Oral presentation


• サイトメガロウイルスIgM 陽性妊婦における先天性感染発生の予測因子

  Tanimura Kenji, Tairaku Shinya, Deguchi Masashi, Morizane Mayumi, Ebina Yasuhiko, Morioka Ichiro, 峰松俊夫, Yamada Hideto

  第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference

  Oral presentation


• IgG avidity とPCR 法を用いたサイトメガロウイルス妊婦スクリーニング

  Tairaku Shinya, Ebina Yasuhiko, 笹川勇樹, 長又哲史, 園山綾子, Morioka Ichiro, Tanimura Kenji, Deguchi Masashi, 峰松俊夫, Yamada Hideto

  第32回日本産婦人科感染症学会学術講演会, May 2015, Japanese, 日本産婦人科感染症学会, 宇都宮, Domestic conference

  Oral presentation


• 免疫グロブリンを用いたサイトメガロウイルス胎児感染予防と胎児治療

  上中美月, Tanimura Kenji, 金子めぐみ, 鷲尾佳一, 出口可奈, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 全新生児を対象とした尿サイトメガロウイルススクリーニングの臨床的有用性

  西田浩輔, Morioka Ichiro, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, Ebina Yasuhiko, 船越 徹, 大橋正伸, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 先天性トキソプラズマ感染の出生前予測に有用なトキソプラズマIgG avidity index cut-off 値

  Tanimura Kenji, 西川 鑑, Tairaku Shinya, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Oral presentation


• 切迫早産入院管理の結果、妊娠29週未満で早産となった児の予後解析

  宇治田直也, Tanimura Kenji, Tairaku Shinya, Shinozaki Nanae, Deguchi Masashi, Morioka Ichiro, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 症候性先天性サイトメガロウイルス感染児の聴性脳幹反応に対する抗ウイルス薬治療の効果

  Morioka Ichiro, 西田浩輔, Deguchi Masashi, Tanimura Kenji, Tairaku Shinya, Ebina Yasuhiko, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 抗SS-A抗体陽性妊婦の胎児大動脈-上大静脈房室伝導時間スクリーニングと先天性完全房室ブロックの発生予防

  荒井貴子, Tairaku Shinya, Tanimura Kenji, 金子めぐみ, Shinozaki Nanae, Deguchi Masashi, Morioka Ichiro, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• サイトメガロウイルスIgM陽性妊婦における先天性感染発生の予知因子

  Tairaku Shinya, Ebina Yasuhiko, Morioka Ichiro, 荒井貴子, 園山綾子, Tanimura Kenji, Deguchi Masashi, 峰松俊夫, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Oral presentation


• Incidence of sequelae in symptomatic congenital cytomegalovirus-infected infants after introduction of newborn urine screening and antiviral treatment.

  Nishida Kosuke, Morioka Ichiro, Kobayashi Yoko, Nakamachi Yuji, Imanishi Takamitsu, Deguchi Masashi, Tanimura Kenji, Funakoshi Toru, Ohashi Masanobu, Inoue Naoki, Iijima Kazumoto, Yamada Hideto

  5th International Congenital CMV Conference, Apr. 2015, English, The QIMR Berghofer Medical Research Institute, Brisbane, オーストラリア, International conference

  Poster presentation


• Follow-Up Study of Infants With Symptomatic Congenital Cytomegalovirus Infection Diagnosed by Urine Screening Soon After Birth

  西田 浩輔, 中町 祐司, 小林 曜子, 岡崎 葉子, 野口 依子, Deguchi Masashi, Tanimura Kenji, Kawano Seiji, Iijima Kazumoto, Yamada Hideto, 森岡 一郎

  Asian Society for Pediatric Research, Apr. 2015, English, osaka, Japan, International conference

  Poster presentation


• Efficacy of antiviral treatment on abnormal auditory brainstem responses in congenital cytomegalovirus-infected infants.

  Morioka Ichiro, Nishida Kosuke, Yamashita Daisuke, Kobayashi Yoko, Nakamachi Yuji, Imanishi Takamitsu, Deguchi Masashi, Tanimura Kenji, Kawano Seiji, Nibu Kenichi, Iijima Kazumoto, Yamada Hedeto

  Pediatric Academic Societies Annual Meeting, Apr. 2015, English, Pediatric Academic Societies, San Diego, アメリカ, International conference

  Poster presentation


• Efficacy of antiviral treatment on abnormal auditory brainstem responses in congenital cytomegalovirus-infected infants.

  Morioka Ichiro, Nishida Kosuke, Yamashita Daisuke, Imanishi Takamitsu, Deguchi Masashi, Tanimura Kenji, Nibu Kenichi, Iijima Kazumoto, Yamada Hideto

  5th International Congenital CMV Conference, Apr. 2015, English, The QIMR Berghofer Medical Research Institute, Brisbane, オーストラリア, International conference

  Poster presentation


• Efficacy of Antiviral Treatment on Abnormal Auditory Brainstem Responses in Congenital Cytomegalovirus-Infected Infants

  森岡 一郎, 西田 浩輔, 山下 大輔, 小林 曜子, 中町 祐司, 今西 孝充, Deguchi Masashi, Tanimura Kenji, Kawano Seiji, Nibu Ken-ichi, Iijima Kazumoto, Yamada Hideto

  2015 Pediatric Academic Society Annual Meeting, Apr. 2015, English, osaka, Japan, International conference

  Poster presentation


• A rapid increase of serum IgG avidity index in women with a congenital cytomegalovirus infection.

  Deguchi Masashi, Ebina Yasuhiko, Minematsu Toshio, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Sonoyama Ayako, Nagamata Shinya, Morizane Mayumi, Yamada Hideto

  第67回日本産科婦人科学会学術講演会, Apr. 2015, English, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 1型糖尿病性腎症・顕性腎症期に妊娠、出産した一症例

  石田 理紗, Goto Shunsuke, Nakai Kentaro, Kouno Kenji, Fujii Hideki, Nishi Shinichi, 石原 あゆみ, Deguchi Masashi, Hara Shigeo

  第25回 腎と妊娠研究会, Mar. 2015, Japanese, 腎と妊娠研究会, 横浜, Domestic conference

  Public discourse


• プロテインS低下女性に対する遺伝子検査の現状

  Shinozaki Nanae, Deguchi Masashi, Tanimura Kenji, Ebina Yasuhiko, Yamada Hideto

  第29回日本生殖免疫学会学術集会, Dec. 2014, Japanese, 日本生殖免疫学会, 東京, Domestic conference

  Oral presentation


• サイトメガロウイルスIgM陽性妊婦における先天性感染発生予知のための前方視的研究

  Tanimura Kenji, Tairaku Shinya, Morizane Mayumi, Ebina Yasuhiko, Deguchi Masashi, Morioka Ichiro, 峰松 俊夫, Yamada Hideto

  厚生労働科学研究助成金（成育疾患克服等次世代育成基盤研究事業）『母子感染の実態把握及び検査・治療に関する研究』平成26年度第3回会議, Dec. 2014, Japanese, 東京, Domestic conference

  Oral presentation


• 先天性アンチトロンビン欠乏症合併妊婦における血栓塞栓症の管理～遺伝子解析結果と臨床像の検討～

  Ebina Yasuhiko, 中町 祐司, Tanimura Kenji, Morizane Mayumi, 森上 聡子, Deguchi Masashi, Kawano Seiji, Yamada Hideto

  第59回日本人類遺伝学会・第21回日本遺伝子診療学会合同大会, Nov. 2014, Japanese, 日本人類遺伝学会・日本遺伝子診療学会, 東京, Domestic conference

  Oral presentation


• 受容体以後のシグナル伝達障害によるインスリン抵抗症を合併し、妊娠中もメトホルミン投与を要した一例

  鷲尾 佳一, 上中 美月, Shinozaki Nanae, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Yamada Hideto, 平田 悠, 西本 祐希, Hirota Yushi, Ogawa Wataru

  第30回日本糖尿病・妊娠学会年次学術集会, Nov. 2014, Japanese, 日本糖尿病・妊娠学会, 長崎, Domestic conference

  Oral presentation


• 受容体以後のシグナル伝達障害によるインスリン抵抗症が疑われ妊娠中メトホルミンが著効した1例

  鷲尾 佳一, 上中 美月, Shinozaki Nanae, Morizane Mayumi, 平田 悠, 西本 祐希, Hirota Yushi, Ogawa Wataru, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第30回糖尿病・妊娠学会年次学術集会, Nov. 2014, Japanese, 糖尿病・妊娠学会, 長崎, Domestic conference

  Oral presentation


• バセドウ病合併妊娠における産科異常と新生児甲状腺機能異常発症の危険因子の検討

  上中 美月, Tanimura Kenji, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第57回日本甲状腺学会学術集会, Nov. 2014, Japanese, 日本甲状腺学会, 大阪, Domestic conference

  Oral presentation


• 免疫グロブリン投与によるサイトメガロウイルス母子感染予防の試み

  出口 可奈, Tanimura Kenji, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference

  Oral presentation


• 不育症診断・治療の最近の話題

  Deguchi Masashi

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Keynote oral presentation


• 不育症と生化学的妊娠

  Maesawa Yoko, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 妊娠により1型糖尿病の悪化をみとめ腎生検を施行した1例

  石田 理紗, Goto Shunsuke, Nakai Kentaro, Kouno Kenji, Fujii Hideki, 石原 あゆみ, Deguchi Masashi, Hara Shigeo, Nishi Shinichi

  第44回 日本腎臓学会西部学術大会, Oct. 2014, Japanese, 日本腎臓学会, 神戸, Domestic conference

  Oral presentation


• 内腸骨動脈閉鎖バルーンカテーテルを用いた前置癒着胎盤に対する帝王切開術

  Tanimura Kenji, Matsuoka Shozo, Morizane Mayumi, Deguchi Masashi, Morita Hiroki, Ebina Yasuhiko, Yamada Hideto

  第38回日本産婦人科手術学会, Oct. 2014, Japanese, 日本産婦人科手術学会, 札幌, Domestic conference

  Oral presentation


• 先天性トキソプラズマ感染症の出生前予測に有用なトキソプラズマ IgG avidity index cut-off値

  Tanimura Kenji, 西川 鑑, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Deguchi Masashi, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 症候性先天性サイトメガロウイルス感染に対する免疫グロブリンを用いた胎児治療

  上中 美月, Tanimura Kenji, 鷲尾 佳一, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Deguchi Masashi, Ebina Yasuhiko, Morioka Ichiro, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference

  Oral presentation


• 治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法

  Deguchi Masashi, Tanimura Kenji, Shinozaki Nanae, Imafuku Hitomi, Maesawa Yoko, Tairaku Shinya, 葉 宜慧, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 原因不明の難治性習慣流産14例に対する60g免疫グロブリン療法

  葉 宜慧, Deguchi Masashi, 中島 由貴, 伊勢由香里, Maesawa Yoko, Shinozaki Nanae, Ebina Yasuhiko, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• プロテインS低下女性に対する遺伝子検査の現状

  Shinozaki Nanae, 上中 美月, 山崎 友維, Tairaku Shinya, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Morita Hiroki, Yamada Hideto

  第131回近畿産科婦人科学会学術集会, Oct. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 母体血清AFP上昇を伴ったBreus Moleの1例

  Ueno Yoshiko, Kitajima Kazuhiro, 前田哲雄, Takahashi Satoru, 田中宇多留, 末永裕子, 西本昌司, Deguchi Masashi, Kawakami Fumi, Yamada Hideto, Itoh Tomoo, Sugimura Kazuro

  The 16th Japanese Society for the Advancement of Women's Imaging, Aug. 2014, Japanese, TheJapanese Society for the Advancement of Women's Imaging, 兵庫, Domestic conference

  Poster presentation


• 胎盤トキソプラズマ感染を認めた2例

  Deguchi Masashi, Matsuoka Shozo, 白川 得朗, 小嶋 伸恵, Tairaku Shinya, Shinozaki Nanae, Suzuki Kaho, Tanimura Kenji, Morioka Ichiro, Yamada Hideto

  第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 千葉, Domestic conference

  Poster presentation


• 胎盤トキソプラズマ感染を認めた2症例

  Deguchi Masashi, Matsuoka Shozo, 白川 得朗, 小嶋 伸恵, Tairaku Shinya, Shinozaki Nanae, Suzuki Kaho, Tanimura Kenji, Morioka Ichiro, Yamada Hideto

  第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 浦安, Domestic conference

  Oral presentation


• 子宮体癌根治術における廓清リンパ節および子宮筋層にリンパ脈管筋腫症細胞を認めた一例

  Morita Hiroki, 山崎 友維, 白川 友香, Tairaku Shinya, Suzuki Kaho, Imafuku Hitomi, Ikuhashi Yoshiyuki, Deguchi Masashi, Miyahara Yoshiya, Niiya Kiyoshi, Ebina Yasuhiko, Kawakami Fumi, Yamada Hideto

  第56回日本婦人科腫瘍学会学術講演会, Jul. 2014, Japanese, 第57回日本婦人科腫瘍学会, 宇都宮, Domestic conference

  Oral presentation


• 近年日本における母子感染の実態

  Tairaku Shinya, Morioka Ichiro, Ebina Yasuhiko, 園山 綾子, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 千葉, Domestic conference

  Oral presentation


• インスリン治療を要した妊娠糖尿病妊婦の臨床像

  小嶋 伸恵, 白川 得朗, Tairaku Shinya, Shinozaki Nanae, Tanimura Kenji, Deguchi Masashi, Matsuoka Shozo, Yamada Hideto

  第50回日本周産期・新生児医学会学術集会, Jul. 2014, Japanese, 日本周産期・新生児医学会, 浦安, Domestic conference

  Oral presentation


• The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study

  Ebina Yasuhiko, Minematsu T, Sonoyama A, Morioka Ichiro, Inoue N, Tairaku Shinya, Nagamata S, Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Yamada Hideto

  39th Annual International Herpesvirus Workshop, Jul. 2014, English, Kobe, Japan, International conference

  [Invited]

  Nominated symposium


• Rapid increase in CMV IgG avidity correlates with cytomegalovirus transmission to the fetus

  Ebina Yasuhiko, Ichihasi S, Tairaku Shinya, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, Minematsu T, Yamada Hideto

  39th Annual International Herpesvirus Workshop, Jul. 2014, English, Kobe, Japan, International conference

  Poster presentation


• 母体血サイトメガロウイルスIgG avidity 測定による先天性感染の発生予知

  長又 哲史, Ebina Yasuhiko, 峰松 俊夫, 園山 綾子, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, 森賓真由美, Deguchi Masashi, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 妊娠中の水痘初感染により子宮内胎児死亡に至った1例

  小嶋 伸恵, Tanimura Kenji, Tairaku Shinya, Shinozaki Nanae, Deguchi Masashi, Matsuoka Shozo, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 妊娠に関連した高安病の6症例

  中島 由貴, Deguchi Masashi, 内田 明子, 市橋さなえ, 出口 可奈, 西野由香里, 西本 昌司, 白川 得朗, 小嶋 伸恵, Tairaku Shinya, Suzuki Kaho, Shinozaki Nanae, Matsuoka Shozo, Yamada Hideto

  第130回近畿産科婦人科学会学術集会, Jun. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 胎盤トキソプラズマ感染を認めた2症例

  Matsuoka Shozo, Tairaku Shinya, Deguchi Masashi, Shinozaki Nanae, Suzuki Kaho, 中島 由貴, 伊勢由香里, Morioka Ichiro, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 全国産科施設を対象としたパルボウイルスB19母子感染の実態調査

  Ebina Yasuhiko, Tairaku Shinya, Morioka Ichiro, Tanimura Kenji, Deguchi Masashi, 長又 哲史, Yamada Hideto

  第55回日本臨床ウイルス学会, Jun. 2014, Japanese, 日本臨床ウイルス学会, 札幌, Domestic conference

  Oral presentation


• 全国産科施設を対象としたパルボウイルスB19母子感染の実態調査

  Ebina Yasuhiko, Tairaku Shinya, Morioka Ichiro, 園山 綾子, Tanimura Kenji, Deguchi Masashi, 長又 哲史, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 全国産科施設を対象としたCMV、トキソプラズマ、風疹、梅毒、単純ヘルペス母子感染の実態調査

  Deguchi Masashi, Tairaku Shinya, Morioka Ichiro, Ebina Yasuhiko, 園山 綾子, Tanimura Kenji, 長又 哲史, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 先天性サイトメガロウイルス（CMV）感染の診断における新生児血中CMV-IgM、アンチゲネミア、CMV-DNA の意義

  Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, 藤田 花織, 黒川 大輔, Nagasaka Miwako, Koda Tsubasa, 横田 知之, Shibata Akio, Iijima Kazumoto, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 症候性先天性サイトメガロウイルス感染児に対する抗ウイルス薬治療

  Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, 藤田 花織, 黒川 大輔, Nagasaka Miwako, Koda Tsubasa, 横田 知之, Shibata Akio, 飯島 誠, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• 周産期リステリア症の2例

  市橋さなえ, Suzuki Kaho, Deguchi Masashi, Matsuoka Shozo, Tanimura Kenji, Morizane Mayumi, Shinozaki Nanae, Tairaku Shinya, Yamada Hideto

  第88回兵庫県産科婦人科学会学術集会, Jun. 2014, Japanese, 日本産科婦人科学会, 神戸, Domestic conference

  Oral presentation


• 子宮下部から子宮前壁を走行する卵膜血管を認めた2例

  西野由香里, Matsuoka Shozo, Deguchi Masashi, 市橋さなえ, 内田 明子, 中島 由貴, 西本 昌司, 白川 得朗, 小嶋 伸恵, Tairaku Shinya, Suzuki Kaho, Shinozaki Nanae, Yamada Hideto

  第130回近畿産科婦人科学会学術集会, Jun. 2014, Japanese, 近畿産婦人科学会, 大阪, Domestic conference

  Oral presentation


• 筋強直性ジストロフィー合併妊娠の2例

  内田 明子, Tairaku Shinya, Shinozaki Nanae, Morizane Mayumi, Tanimura Kenji, Deguchi Masashi, Matsuoka Shozo, Yamada Hideto

  第88回兵庫県産科婦人科学会学術集会, Jun. 2014, Japanese, 日本産科婦人科学会, 神戸, Domestic conference

  Oral presentation


• 寒冷凝集素症合併妊娠の一例

  豊永 絢香, 中島 由貴, Deguchi Masashi, Shinozaki Nanae, Tairaku Shinya, Suzuki Kaho, Matsuoka Shozo, Yamada Hideto

  平成26年度兵庫県母性衛生学会学術集会, Jun. 2014, Japanese, 兵庫県母性衛生学会, 神戸, Domestic conference

  Oral presentation


• サイトメガロウイルス先天性感染例においてIgG avidity index は急速に増加する

  市橋さなえ, Ebina Yasuhiko, Tairaku Shinya, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, 峰松 俊夫, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• サイトメガロウイルス先天性感染例においてIgG avidity indexは急速に増加する

  Ebina Yasuhiko, 峰松 俊夫, 市橋さなえ, Tairaku Shinya, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, Yamada Hideto

  第55回日本臨床ウイルス学会, Jun. 2014, Japanese, 日本臨床ウイルス学会, 札幌, Domestic conference

  Oral presentation


• The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study.

  Ebina Yasuhiko, Toshio Minematsu, Ayako Sonoyama, Morioka Ichiro, Naoki Inoue, Tairaku Shinya, Satoshi Nagamata, Tanimura Kenji, Morizane Mayumi, Deguchi Masashi, Yamada Hideto

  The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conference

  Poster presentation


• Rapid increase in CMV IgG avidity correlates with cytomegalovirus transmission to the fetus.

  Ebina Yasuhiko, Sanae Ichihashi, Tairaku Shinya, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, Toshio Minematsu, Yamada Hideto

  The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conference

  Poster presentation


• MHCクラスII の新しい抗原提示機能は抗リン脂質抗体症候群の病態と関連する

  Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto, 荒瀬 尚, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto, 荒瀬 尚

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Oral presentation


• Low total IgM values and high cytomegalovirus loads in the blood of newborns with symptomatic congenital cytomegalovirus infection.

  Morioka Ichiro, Yoko Kobayashi, Koda Tsubasa, Yuji Nakamachi, Yoko Okazaki, Yoriko Noguchi, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Kawano Seiji, Iijima Kazumoto, Yamada Hideto

  The 39th Annual International Herpesvirus Workshop, Jun. 2014, English, NOVARTIS, 神戸, International conference

  Poster presentation


• IgG AvidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング【シンポジウム】母子感染～妊婦スクリーニングの効果と課題～

  Tairaku Shinya, Ebina Yasuhiko, 笹川 勇樹, 長又 哲史, 園山 綾子, 伊勢由香里, Morioka Ichiro, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, Yamada Hideto

  第31回日本産婦人科感染症研究会, Jun. 2014, Japanese, 日本産婦人科感染症研究会, 神戸, Domestic conference

  Public symposium


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  笹川 勇樹, Ebina Yasuhiko, 長又 哲史, 園山 綾子, 伊勢 由香里, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, Yamada Hideto

  第130回近畿産科婦人科学会学術集会, Jun. 2014, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference

  Oral presentation


• 妊娠35週より急速に増大した胎児脳腫瘍の1例

  山崎 友維, Miyahara Yoshiya, Tairaku Shinya, Shinozaki Nanae, Deguchi Masashi, Morita Hiroki, Yamada Hideto

  日本超音波医学会第87回学術集会, May 2014, Japanese, 日本超音波医学会, 横浜, Domestic conference

  Oral presentation


• 分娩後出血に対する選択的動脈塞栓術無効に関連する因子の検討

  山崎 友維, Morita Hiroki, Tairaku Shinya, Shinozaki Nanae, Deguchi Masashi, Matsuoka Shozo, Miyahara Yoshiya, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Others


• 不育症患者における非妊娠時の末梢血NK細胞活性と妊娠帰結

  伊勢由香里, Deguchi Masashi, 中島 由貴, 白川 得朗, Maesawa Yoko, Shinozaki Nanae, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 不育症および自己免疫疾患における抗リン脂質抗体陽性患者の妊娠帰結

  Miyahara Yoshiya, Deguchi Masashi, Shinozaki Nanae, Tanimura Kenji, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 妊娠35週より急速に増大した胎児脳腫瘍の1例

  内田 明子, 山崎 友維, 牧原 夏子, Ikuhashi Yoshiyuki, Matsuoka Shozo, Deguchi Masashi, Miyahara Yoshiya, Morita Hiroki, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 先天性サイトメガロウイルス（CMV）感染の診断における新生児血中CMV-IgM、アンチゲネミア、CMV-DNAの意義

  Morioka Ichiro, Tairaku Shinya, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Public symposium


• 人工透析導入を回避しえた糖尿病性腎症3B期合併妊娠の1例

  石原あゆみ, Matsuoka Shozo, Deguchi Masashi, 森上 聡子, Shinozaki Nanae, 笹川 勇樹, 山下 萌, 中島 由貴, 伊勢由香里, Tairaku Shinya, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 治療抵抗性の抗リン脂質抗体症候群合併妊娠に対する大量免疫グロブリン療法

  Deguchi Masashi, Miyahara Yoshiya, Tanimura Kenji, 白川 得朗, Shinozaki Nanae, Maesawa Yoko, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 抗リン脂質抗体症候群母体から出生した児に胃破裂を発症した1例

  山下 萌, Deguchi Masashi, Morita Hiroki, Matsuoka Shozo, Tairaku Shinya, Shinozaki Nanae, 小嶋 伸恵, 中島 由貴, 伊勢 由香里, 石原 あゆみ, Morioka Ichiro, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 原因不明かつ6回以上自然流産の既往のある治療抵抗性・難治性習慣流産14人に対する60g免疫グロブリン療法

  中島 由貴, Deguchi Masashi, 伊勢由香里, 白川 得朗, Maesawa Yoko, Shinozaki Nanae, Ebina Yasuhiko, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 近年日本における母子感染の実態

  Tairaku Shinya, Morioka Ichiro, Ebina Yasuhiko, 長又 哲史, 園山 綾子, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 近年における母子感染の実態

  Tairaku Shinya, Morioka Ichiro, 長又 哲史, Ebina Yasuhiko, 園山 綾子, Tanimura Kenji, Deguchi Masashi, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• 急速なIgG Avidity index上昇はサイトメガロウイルス先天性感染の発生予知因子である

  市橋 さなえ, Ebina Yasuhiko, Tairaku Shinya, Deguchi Masashi, Morioka Ichiro, Tanimura Kenji, 峰松 俊夫, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• プロテインS低下不育症の妊娠帰結

  Shinozaki Nanae, Deguchi Masashi, 森上 聡子, Maesawa Yoko, Tairaku Shinya, Matsuoka Shozo, Ebina Yasuhiko, Morita Hiroki, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• The IgG avidity value for the prediction of congenital cytomegalovirus infection in a prospective cohort study.

  Satoshi Nagamata, Ebina Yasuhiko, Toshio Minematsu, Ayako Sonoyama, Morioka Ichiro, Tairaku Shinya, Keiji Tanimura, Morizane Mayumi, Deguchi Masashi, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, English, 日本産科婦人科学会, 東京, Domestic conference

  Public symposium


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  笹川 勇樹, Ebina Yasuhiko, 長又 哲史, 園山 綾子, 伊勢 由香里, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• HLAクラスII/β2-glycoprotein Iタンパク質複合体は抗リン脂質抗体症候群の病態に関わる主要な標的分子である。

  Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto, 荒瀬 尚

  第66回日本産科婦人科学会学術講演会, Apr. 2014, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Poster presentation


• Association between protein C, protein S, factor XII, and spontaneous abortion, adverse

  Ebina Yasuhiko, Kobashi G, Deguchi Masashi, Minakami H, Yamada Hideto

  第66回日本産科婦人科学会学術講演会, Apr. 2014, English, 日本産科婦人科学会, 東京, Domestic conference

  Others


• MHC class IIの新しい抗原提示機構は抗リン脂質抗体症候群の病態に関連する

  Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto, 荒瀬 尚

  平成26年度位育会総会, Feb. 2014, Japanese, 位育会, 神戸, Domestic conference

  Others


• IgG avidityとPCR法を用いたサイトメガロウイルス妊婦スクリーニング

  笹川 勇樹, Ebina Yasuhiko, 長又 哲史, 園山 綾子, 伊勢由香里, Morioka Ichiro, Tairaku Shinya, Tanimura Kenji, Deguchi Masashi, 峰松 俊夫, Yamada Hideto

  第5回神戸産婦人科臨床フォーラム, Jan. 2014, Japanese, 兵庫県産科婦人科学会, 神戸, Domestic conference

  Oral presentation


• Cellular misfolded proteins transported to the cell surface by MHC class II molecules are targets for autoantibodies in autoimmune diseases

  Tanimura Kenji, Deguchi Masashi, Ebina Yasuhiko, Yamada Hideto, 荒瀬 尚

  平成25年度大阪大学微生物病研究所業績発表会, Jan. 2014, Japanese, 大阪大学, 大阪, Domestic conference

  Oral presentation


• 当院におけるプロテインS低下症例に関する検討

  篠崎 奈々絵, 出口 雅士, 前澤 陽子, 森田 宏紀, 山田 秀人

  日本生殖医学会雑誌, Oct. 2013, Japanese


• K2-7-2 卵母細胞由来Interleukin 7(IL-7)はPI3K/AKT回路を介し卵巣顆粒膜細胞のアポトーシスを抑制し卵母細胞の核成熟を促進する(高得点演題7,生殖医学)

  山田 愛, 出口 雅士, JW Hsueh Aaron, 中林 幸士, 山田 秀人

  日本産科婦人科學會雜誌, 2012, Japanese, 日本産科婦人科学会


• 先天性アンチトロンビンIII欠乏症合併妊娠9例の検討

  森実 真由美, 武居 智信, 鈴木 嘉穂, 牧原 夏子, 天野 真理子, 森本 規之, 出口 雅士, 森田 宏紀, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会雑誌, 2010, Japanese, 日本周産期・新生児医学会


• Pregnancy outcome in patients with systemic lupus erythematosus

  天野 真理子, 牧原 夏子, 園山 綾子, 鈴木 嘉穂, 森本 規之, 森実 真由美, 出口 雅士, 森田 宏紀, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会雑誌, 2010, Japanese, 日本周産期・新生児医学会


• Uterine Artery Embolization for Obstetrical Hemorrhage

  山崎 友雄, 森田 宏紀, 白川 得朗, 吉田 奈央, 牧原 夏子, 鈴木 嘉穂, 天野 真理子, 森本 規之, 森実 真由美, 出口 雅士, 山崎 峰夫, 山田 秀人

  日本周産期・新生児医学会雑誌, 2010, Japanese, 日本周産期・新生児医学会


• ＩＣＧ蛍光法を用いて術中骨盤内lymphnode navigationを施行した腟悪性黒色腫の１例

  Ikeda Tetsuya, Nishigori Chikako, Deguchi Masashi, Yoshida Shigeki

  日本皮膚科学会第416回大阪地方会, Dec. 2009, Japanese, 大阪地方会, 大阪, Domestic conference

  Oral presentation


• 持効型溶解インスリンアナログを用いた一型糖尿病合併妊婦の管理経験

  Ashitani Naoko, Makihara Natsuko, Deguchi Masashi, Matsuoka Shozo, Kitao Keisuke, Morita Hiroki, Ohara Noriyuki, Yamasaki Mineo, Maruo Takeshi, Ogawa Wataru

  第117回近畿産科婦人科学会学術集会, Nov. 2007, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference

  Oral presentation


• 巨大外陰部腫瘤の一症例

  Sugimoto Makoto, Takemura Naoya, Deguchi Masashi, Nakabayashi Koji, Yoshida Shigeki, Yamasaki Mineo, Maruo Takeshi

  第117回近畿産科婦人科学会学術集会, Nov. 2007, Japanese, 近畿産科婦人科学会, 大阪, Domestic conference

  Oral presentation


• 第一子が前期破水の二絨毛膜双胎の肺低形成評価に三次元超音波検査が有用であった一例

  Ashitani Naoko, Morita Hiroki, Makihara Natsuko, Matsuoka Shozo, Deguchi Masashi, Kitao Keisuke, Yamasaki Mineo, Maruo Takeshi

  第43回日本周産期・新生児医学会学術集会, Jul. 2007, Japanese, 日本周産期・新生児医学会, 東京, Domestic conference

  Oral presentation


• 治療に苦慮したリンパ嚢腫症例

  Sugimoto Makoto, Takemura Naoya, Deguchi Masashi, Nakabayashi Koji, Yoshida Shigeki, Yamasaki Mineo, Maruo Takeshi

  第81回兵庫県産科婦人科学会学術集会, Jul. 2007, Japanese, 兵庫県産科婦人科学会, 神戸, Domestic conference

  Oral presentation


• 産後大量出血のため内腸骨動脈塞栓術を受けた後の妊娠で癒着胎盤をきたした一症例

  Makihara Natsuko, Kitao Keisuke, Amano Mariko, Ashitani Naoko, Deguchi Masashi, Matsuoka Shozo, Morita Hiroki, Yamasaki Mineo, Maruo Takeshi

  第43回日本周産期・新生児医学会学術集会, Jul. 2007, Japanese, 日本周産期・新生児医学会, 東京, Domestic conference

  Oral presentation


• Super high-dose intraarterial CDDP infusion under percutaneous pelvic perfusion with extracorporeal chemofiltration for advanced uterine cervical cancer

  Maruo Takeshi, Motoyama Satoru, Yoshida Shigeki, Deguchi Masashi

  The7thInternationalOperativeWorkshop, Jul. 2007, English, Frauenklinik, Klinikum Bayreuth Gmbh, Mayo Clinic, USA, Bayreuth, Germany, International conference

  [Invited]

  Invited oral presentation


• 当院で経験した腹膜偽粘液腫十一症例の検討

  Nakabayashi Koji, Takemura Naoya, Amano Mariko, Deguchi Masashi, Yoshida Shigeki, Yamasaki Mineo, Maruo Takeshi

  第116回近畿産科婦人科学会学術集会, Jun. 2007, Japanese, 近畿産科婦人科学会, 大津, Domestic conference

  Oral presentation


• 子宮内膜症におけるVascular endothelial growth factor遺伝子多型の解析

  Ikuhashi Yoshiyuki, Yoshida Shigeki, Ohara Noriyuki, Takemura Naoya, Sugimoto Makoto, Amano Mariko, Kitao Keisuke, Deguchi Masashi, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮内膜症におけるepithelial growth factor ならびに epithelial ｇrowth factor receptor 遺伝子多型の解析

  Yoshida Shigeki, Ohara Noriyuki, Kitao Keisuke, Sugimoto Makoto, Takemura Naoya, Ikuhashi Yoshiyuki, Amano Mariko, Deguchi Masashi, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮体癌におけるvascular endothelial growth factor遺伝子多型の解析

  Amano Mariko, Yoshida Shigeki, Ohara Noriyuki, Takemura Naoya, Sugimoto Makoto, Ikuhashi Yoshiyuki, Kitao Keisuke, Deguchi Masashi, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮体癌におけるepidermal growth factor receptor, human epidermal growth factor receptor 2 遺伝子多型の解析

  Kitao Keisuke, Yoshida Shigeki, Ohara Noriyuki, Takemura Naoya, Sugimoto Makoto, Ikuhashi Yoshiyuki, Amano Mariko, Deguchi Masashi, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮体癌におけるcatechol-O-methyltransferase遺伝子多型の解析

  Deguchi Masashi, Yoshida Shigeki, Ohara Noriyuki, Takemura Naoya, Sugimoto Makoto, Ikuhashi Yoshiyuki, Amano Mariko, Kitao Keisuke, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮筋腫におけるcatechol-O-methyltransferase遺伝子多型の解析

  Sugimoto Makoto, Yoshida Shigeki, Ohara Noriyuki, Takemura Naoya, Ikuhashi Yoshiyuki, Amano Mariko, Deguchi Masashi, Kitao Keisuke, Maruo Takeshi

  第59回日本産科婦人科学会学術講演会, Apr. 2007, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• インスリンアナログによる糖尿病合併妊婦の治療 持効型溶解インスリンアナログを用いた一型糖尿病合併妊婦の管理経験

  ASHITANI NAOKO, MORITA HIROKI, KITAO KEISUKE, DEGUCHI MASASHI, Matsuoka Shozo, OHARA NORIYUKI, YAMASAKI MINEO, MARUO TAKESHI

  第22回日本糖尿病・妊娠学会、ワークショップ, Nov. 2006, Japanese, 日本糖尿病・妊娠学会, 東京, Domestic conference

  Oral presentation


• 当科での子宮癌肉腫十三症例の検討

  TAKEMURA NAOYA, DEGUCHI MASASHI, Nakabayashi Koji, YOSHIDA SHIGEKI, YAMASAKI MINEO, MARUO TAKESHI

  第44回日本癌治療学会, Oct. 2006, Japanese, 日本癌治療学会, 東京, Domestic conference

  Poster presentation


• 過去五年間に経験した腹膜偽粘液腫十一症例の検討

  Nakabayashi Koji, TAKEMURA NAOYA, DEGUCHI MASASHI, YOSHIDA SHIGEKI, YAMASAKI MINEO, MARUO TAKESHI

  第44回日本癌治療学会, Oct. 2006, Japanese, 日本癌治療学会, 東京, Domestic conference

  Poster presentation


• 食道静脈瘤からの出血を繰り返したアルコール性肝硬変合併妊娠の管理経験

  MORITA HIROKI, DEGUCHI MASASHI, KITAO KEISUKE, YAMASAKI MINEO, MARUO TAKESHI

  第42回日本周産期・新生児医学会学術集会, Jul. 2006, Japanese, 日本周産期・新生児医学会, 宮崎, Domestic conference

  Oral presentation


• 子宮体癌発症におけるMatrix metalloproteinase-1, -9遺伝子多型の解析

  YOSHIDA SHIGEKI, OHARA NORIYUKI, DEGUCHI MASASHI, TAKEMURA NAOYA, MARUO TAKESHI

  第58回日本産科婦人科学会総会・学術講演会, Apr. 2006, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 子宮筋腫におけるMatrix metalloproteinase(MMP)-1ならびにMMP-9遺伝子多型の解析

  TAKEMURA NAOYA, YOSHIDA SHIGEKI, OHARA NORIYUKI, DEGUCHI MASASHI, MARUO TAKESHI

  第58回日本産科婦人科学会総会・学術講演会, Apr. 2006, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• IVF-ET試行後に重症OHSSと左鎖骨下静脈血栓症を発症した二症例

  KITAO KEISUKE, OHARA NORIYUKI, DEGUCHI MASASHI, MORITA HIROKI, MARUO TAKESHI

  第58回日本産科婦人科学会総会・学術講演会, Apr. 2006, Japanese, 日本産科婦人科学会, 横浜, Domestic conference

  Poster presentation


• 当科における産科出血に対する選択的子宮動脈塞栓術の現況

  鈴木 嘉穂, MORITA, Hiroki, 斎田 有紀, 生橋 義之, 森川 哲, 市田 耕太郎, DEGUCHI, Masashi, OHARA, Noriyuki, KITAO, Keisuke, MARUO, Takeshi

  第1１３回近畿産婦人科学会, Oct. 2005, Japanese, 近畿産婦人科学会, 滋賀, Domestic conference

  Oral presentation


• 肺リンパ管筋腫症合併妊娠の１例

  藤本 美樹, 佐々木 紘子, MORITA, Hiroki, DEGUCHI, Masashi, KITAO, Keisuke, FUNAKOSHI,Toru, OHARA, Noriyuki, MARUO, Takeshi

  第1７回兵庫県母性衛生学会, Jul. 2005, Japanese, 兵庫県母性衛生学会, 神戸, Domestic conference

  Oral presentation


• 妊娠28週で発症し寛解導入後に帝王切開術で健児を得たALLの1例

  森川 哲, KITAO, Keisuke, MORITA, Hiroki, 甲角 真子, DEGUCHI, Masashi, OHARA, Noriyuki, MARUO, Takeshi

  第7９回兵庫県産婦人科学会, Jul. 2005, Japanese, 兵庫県産婦人科学会, 神戸, Domestic conference

  Oral presentation


• Update of neoadjuvant chemotherapy using percutaneous pelvic perfusion with extracorporeal chemofiltration (PPPEC) for advanced uterine cervical carcinoma

  MARUO, Takeshi, MOTOYAMA,Satoru, HAMANA, Shinya, DEGUCHI, Masashi

  6th International Operative Workshop, Jul. 2005, English, Bayreuth, International conference

  [Invited]

  Invited oral presentation


• 肺リンパ管筋腫症合併妊娠の１例

  藤本 美樹, 佐々木 紘子, MORITA, Hiroki, DEGUCHI, Masashi, KITAO, Keisuke, FUNAKOSHI,Toru, OHARA, Noriyuki, MARUO, Takeshi

  第1１２回近畿産婦人科学会, Jun. 2005, Japanese, 近畿産婦人科学会, 和歌山, Domestic conference

  Oral presentation


• 子宮内膜症における N-acetyltransferase (NAT) 1ならびに NAT2 遺伝子領域におけるTDT （伝達不平衡） 解析

  YOSHIDA, Shigeki, DEGUCHI, Masashi, 生橋 義之, 竹村 直也, 杉本 誠, OHARA, Noriyuki, MARUO, Takeshi, ステイーブン ケネデイー

  第五十七回日本産科婦人科学会総会・学術講演会, Apr. 2005, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 子宮内膜症における Intercellular adhesion molecule-1 (ICAM-1) 遺伝子多型の解析

  山下 正子, YOSHIDA, Shigeki, DEGUCHI, Masashi, 生橋 義之, 竹村 直也, 杉本 誠, OHARA, Noriyuki, MARUO, Takeshi, ステイーブン ケネデイー

  第五十七回日本産科婦人科学会総会・学術講演会, Apr. 2005, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• シスプラチン感受性卵巣癌細胞の増殖とアポトーシスに及ぼす Imatinib mesylate の影響の検討

  DEGUCHI, Masashi, MOTOYAMA,Satoru, ジョベル フェルナンデス, 浜名 伸也, ベンジャミン ツァン, MARUO, Takeshi

  第五十七回日本産科婦人科学会総会・学術講演会, Apr. 2005, Japanese, 日本産科婦人科学会, 京都, Domestic conference

  Oral presentation


• 日本人子宮筋腫患者における CYP17MspA1 遺伝子多型の解析

  辻野 太郎, OHARA, Noriyuki, YOSHIDA, Shigeki, 大森 伸也, 森實 真由美, DEGUCHI, Masashi, MARUO, Takeshi, ステイーブン・ケネディー

  第五十六回日本産科婦人科学会学術講演会, Apr. 2004, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Oral presentation


• 子宮内膜症における N－acetyltransferase (NAT)1 ならびに NAT2 遺伝子多型の解析

  DEGUCHI, Masashi, YOSHIDA, Shigeki, 大森 伸也, 森實 真由美, MARUO, Takeshi, ステイーブン・ケネディー

  第五十六回日本産科婦人科学会学術講演会, Apr. 2004, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Oral presentation


• 子宮内膜症における N-acetyltransferase (NAT) 1 ならびに NAT2遺伝子多型の解析 －家族性子宮内膜症と非家族性子宮内膜症の比較－

  YOSHIDA, Shigeki, 大森 伸也, 森實 真由美, DEGUCHI, Masashi, MARUO, Takeshi, ステイーブン ケネデイー

  第五十六回日本産科婦人科学会学術講演会, Apr. 2004, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Oral presentation


• 子宮筋腫患者における ERαならびに ERβ遺伝子多型の解析

  大森 伸哉, YOSHIDA, Shigeki, 辻野 太郎, 森實 真由美, DEGUCHI, Masashi, OHARA, Noriyuki, MARUO, Takeshi

  第五十六回日本産科婦人科学会学術講演会, Apr. 2004, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Oral presentation


• Tumor necrosis factor-α-1031T/C promoter polymorphism is associated with an increased risk of endometriosis in a Japanese population

  Tasneem Asghar, YOSHIDA, Shigeki, 大森 伸哉, 森實 真由美, DEGUCHI, Masashi, 王 茁, Steven Kennedy, MARUO, Takeshi

  第五十六回日本産科婦人科学会学術講演会, Apr. 2004, Japanese, 日本産科婦人科学会, 東京, Domestic conference

  Oral presentation


• Super high-dose intraarterial CDDP infusion under percutaneous pelvic perfusion with extracorporeal chemofiltration for advanced uterine cervical cancer

  MOTOYAMA,Satoru, DEGUCHI, Masashi, HAMANA, Shinya, YOSHIDA, Shigeki, KU, Yeisei, 宮原 義也, 立岩 洋一, MARUO, Takeshi

  Special Lecture, Oct. 2003, English, Bali, International conference

  [Invited]

  Invited oral presentation


• 子宮頸部扁平上皮細胞の癌化における活動型 Notch1 発現の検討

  DEGUCHI, Masashi, HAMANA, Shinya, MORIYAMA,Toshitake, YOSHIDA, Shigeki, MOTOYAMA,Satoru, MARUO, Takeshi

  第五十五回日本産科婦人科学会, Apr. 2003, Japanese, 日本産科婦人科学会, 福岡, Domestic conference

  Oral presentation

• 日本周産期新生児学会


• 婦人科腫瘍学会


• 日本癌治療学会


• 日本産科婦人科学会

• 末梢血・脱落膜免疫細胞プロファイル網羅的解析による不育症関連免疫異常の病態解析

  出口 雅士, 益子 尚久, 今福 仁美, 宮西 正憲, 谷村 憲司, 寺井 義人

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2025 - 31 Mar. 2028


• Elucidation of the mechanism of neoself antibody-induced recurrent pregnancy loss using model mice and development of the treatment methods

  谷村 憲司, 出口 雅士, 今福 仁美, 寺井 義人

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2024 - 31 Mar. 2027


• Early diagnosis of ovarian cancer using vaginal secretion extracted miRNA and development of nucleic acid therapy using artificial exosomes

  寺井 義人, 高橋 良輔, 笹川 勇樹, 出口 雅士, 長又 哲史, 犬伏 祥子, 竹内 俊文, 南 康博, 谷村 憲司, 若橋 宣, 遠藤 光晴

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2024 - 31 Mar. 2027


• ネオ・セルフ抗体による不妊症、子宮内膜症の病態解明と治療法の確立

  山田 秀人, 吉野 修, 荒瀬 尚, 出口 雅士, 小野 洋輔, 谷村 憲司, 太田 創

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  1）観察研究として、ネオ・セルフ抗体陽性の不育症女性のその後の47妊娠において、無治療とLDA/ヘパリン療法の生児獲得率を比較した。無治療6人とPSL 5mg/日2人の生産率50％（4人）に比べて、LDA/ヘパリン療法39人では生産率87.2％（34人）が上昇した（p<0.01）（投稿中）。 2）前向きコホート研究として、ART患者148人を含む不妊症女性224人において、同意を得てネオセルフ抗体を測定した、3回以上の胚移植後の着床不成功を反復着床不全（RIF）と定義した。不妊症の17.9％（40人）でネオセルフ抗体が陽性であった。不妊症女性において子宮内膜症（陽性率28.9％、OR 3.0、95％CI 1.3-7.0）が、またART患者においてはRIF（27.8％、2.9、1.1-8.1）が、ネオ・セルフ抗体陽性と関係する疾患であることを初めて明らかにした（J Reprod Immunol 2023）。抗体陽性の不妊症や反復着床不全には、LDA/ヘパリン療法が有効である可能性がある。 3）APS 66人、aPLキャリア78人、動脈血栓77人、動静脈血栓症14人を含む全身性リウマチ性疾患の女性704人において、同意を得てネオ・セルフ抗体を測定した。特に、動静脈血栓症、aGAPSS>10、aPL triple-positiveでは、抗体は高値であった。抗体基準値＞172.4 Uによって、動脈血栓症リスク（OR 5.1、95％CI 2.9-9.2）を予測できた。全身性リウマチ性疾患において、ネオ・セルフ抗体は動脈血栓症リスクであることを初めて明らかにした（Arthritis Res Ther 2023）


• Development of a mouse model for therapies of pregnancy complications caused by abeta2GPI/MHC class II

  山田 秀人, 荒瀬 尚, 笹川 勇樹, 出口 雅士, 谷村 憲司

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2020 - 31 Mar. 2023

  前方視的研究として、不育症、IUFD、HDP、FGR、34週未満早産の既往や現症を有する女性に対して、同意を得てネオ・セルフ抗体を測定した。観察研究として、ネオ・セルフ抗体陽性の妊娠合併症既往の女性においては、次回妊娠で、無治療、LDA単独療法、LDA＋ヘパリン療法の生児獲得率を比較し治療効果を調べた。 不育症428人、FGR120人、HDP107人、34週以前早産72人、膠原病78人、正期産412人で抗β2GPI/HLA-DR7抗体測定を実施した。抗β2GPI/HLA-DR7抗体の陽性率（陽性≧73.3 U）は、不育症18.9％(81/428)、FGR15.8％(19/120)、HDP14.0％(15/107)、34週以前早産8.3％ (6/107)、膠原病34.6％(27/78)、正期産7.8％（32/412）であった。さらに原因・リスク因子不育症217人中40人（18.4％）で抗β2GPI/HLA-DR7抗体が陽性であった。産科異常、膠原病のない正期産に限定すると、抗体陽性率は6.9％（17/248）であった。 一方、2021年12月までに、不育症女性において抗β2GPI/HLA-DR7抗体陽性判明後の全75妊娠から染色体異常流産7妊娠を除いた68妊娠について解析した。LDAのみの13妊娠では、生産10例（76.9％）、妊娠継続中1例(7.7％)、流産2例(15.4％)であり、LDA+ヘパリン39妊娠では、生産26例（66.7％）、妊娠継続中6例(15.4％)、流産7例(17.9％)であった。一方、治療なし、もしくはステロイドのみ10妊娠（治療なし6妊娠、ステロイドのみ4妊娠）では、生産5例（50％）、妊娠継続中0例(0％)、流産5例(50％)だった。抗β2GPI/HLA-DR7抗体陽性の不育症に対して、LDAやLDA+ヘパリン療法が有効である可能性がある。


• 妊娠初期のプロテインS、プロテインC抗凝固因子の変動と産科異常との関連解析

  出口 雅士, 山田 秀人, 谷村 憲司, 笹川 勇樹

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023

  全妊婦対象の前向きコホート研究については、妊娠8-12週の当院妊婦外来に通院中の母体を対象に遊離プロテインS抗原量と活性、Dダイマー、可溶性フィブリンモノマー、総プロテインS抗原量ならびに活性と比活性を測定している。プロテインC系全体の活性を測定する検査キットであるThrombopasについては、販売が終了となったため、約1000件で測定を終了した。順調に症例を集積し、その他の項目については2022年3月31日までに約1400件の検体を採取し、妊娠初期の採血を終了した。採血に際して特に有害事象の発生はなかった。今後、介入なく通常の妊娠経過観察を行い、産科異常の発生状況との関連を調べるため、臨床情報の収集を行って解析を行う。総プロテインS比活性の低下を認めた症例において、本人の同意を得らることはできず、プロテインS遺伝子異常の解析は行えなかった。 妊娠による検査値変動についての研究についても、合併症のない妊婦約50例で上と同様の検査項目を妊娠10週、18週、28週、36週 (±2週) で測定した。産褥1ヶ月での測定は、臨床上の採血の機会がなく実施していない。今後妊娠中のプロテインS値の変動についても解析を行う。当院不育外来に通院中の患者および抗リン脂質抗体が陽性と診断されている妊婦40例についても上と同様の検査項目を測定し、結果に基づく介入なく通常の妊娠 経過観察を行っており、こちらも臨床情報の収集を並行して行っている。 抗プロテインS自己抗体と妊娠予後の関連の解析については、プロテインSの抗体測定系の確立を行っているところである。ドットブロットでPVDF膜に滴下するプロテインSの濃度(量)ならびに反応させるプロテインS低下女性の精製IgGの濃度(量)条件設定を行っており、その条件設定をもとにスロットブロットに移行 する予定にしている。


• 2光子顕微鏡による胎仔ミクログリアが仔の成長発達に及ぼす影響の解明

  谷村 憲司, 山田 秀人, 笹川 勇樹, 出口 雅士

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023

  妊娠中の母体の感染症や飢餓、過食などによる様々な胎児へのストレスがその児の自閉症などの発達障害、統合失調症などの精神疾患のリスクを上昇させることが知られています。脳を構成する細胞の一つであるミクログリアという細胞は、胎児期の早い時期に脳に定着して外敵から胎児の脳を守る働きをしていると考えられいます。さらに、ミクログリア細胞は、中枢神経が発達する過程で神経細胞の間の余分な連絡を断ち切ることによって適切な神経回路を作り上げることを可能にしています。本研究では、妊婦マウスがウイルス感染などの炎症や飢餓・過食などのストレスにさらされている状況を人工的に作り出し、2光子顕微鏡という特別な顕微鏡を使って生きた胎児マウスや思春期マウスのミクログリアの動きをリアルタイムに観察することで母体へのストレスが児の脳に及ぼす影響をミクログリアに焦点を当てて解明しようとしています。これまでにウイルス感染が起こった状態を人工的に作り出した妊娠マウスでは、何の処理もしていない正常な妊婦マウスと比べて胎児ミクログリアの動く速さは早くなっていましたが、生後10日目のマウスでは、逆にウイルス感染疑似母親マウスから生まれたマウスで遅くなっていることが分かりました。また、ウイルス感染疑似妊娠マウスではその胎児マウスの神経細胞の突起が正常妊娠マウスの胎児のそれより長く、神経細胞の本体がより小さくなっていいました。これらのことより母親の炎症によるストレスが胎児のミクログリア細胞の動きや形に変化を引き起こすことで神経回路の形成に影響している可能性があることが分かりました。


• 生殖不全における制御性B細胞、樹状細胞、NK細胞の役割の解明

  出口 雅士

  学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020, Principal investigator

  Competitive research funding


• HLA class Ⅱ複合体抗体による不育症、妊娠合併症の新診断・治療法の確立

  山田 秀人

  学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020

  Competitive research funding


• Pathogenic microorganism identification in neonatal infectious diseases by a meta-genomic analysis using the next generation sequencer

  MORIOKA Ichiro, MORI Yasuko, DEGUCHI Masashi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2014 - 31 Mar. 2017

  The purpose of this study was to establish a meta-genomic analysis using the next generation sequencer for perinatal and neonatal infectious diseases, and to identify pathogenic microorganisms that had been difficult to identify to date. As results, a meta-genomic analysis system using the next generation sequencer was established during the study period and we applied to the neonatal and pediatric patients with infection. We obtained new findings from patient specimens using these techniques, and for the first time, reported the cases to the international journals, such as a newborn with persistent pulmonary hypertension who was detected echovirus 7 from not only the serum, nasal swab and bronchoalveolar lavage, but also the preserved umbilical cord, a pediatric patient due to enterovirus D68 infection that developed interstitial pneumonia, and a newborn with congenital cytomegalovirus infection with retinal arterio-venous anastomosis.


• β2GPI/MHCクラスIIに対する自己抗体の証明と産科異常病因解析

  山田 秀人

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• 母子感染の検査に関する研究（２）

  山田 秀人

  デンカ生研株式会社, 厚生労働科学研究費補助金成育疾患克服等次世代育成基盤事業, 2017

  Competitive research funding


• 母子感染の検査に関する研究（１）

  山田 秀人

  バイオ・ラッドラボラトリーズ株式会社, 厚生労働科学研究費補助金成育疾患克服等次世代育成基盤事業, 2017

  Competitive research funding


• Analysis of UGT1A1 polymorphisms predictive for adverse effect in patients treated with irinotecan.

  DEGUCHI Masashi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Kobe University, 2007 - 2008, Principal investigator

  日本人の婦人科癌患者においてもUGT1A1 *6・*28のアレル頻度は日本人における肺症小細胞癌や大腸癌などの固形癌患者における研究と同様の結果であった。日本人婦人科癌患者においてもUGT1A1 *6ヘテロ かつ*28ヘテロ接合体、またはUGT1A1 *6ホモ接合体の遺伝子多型は、塩酸イリノテカンを用いた抗癌化学療法に伴う高度の好中球減少の発現と関連する可能性がある。

  Competitive research funding