Research activity information

• Mar. 2013 日本循環器学会, 女性研究者奨励賞, Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER). Satomi-Kobayashi S, et al. J Biol Chem. 2012 Aug 31;287(36):30336-45.

  Kobayashi Seimi

  Japan society

• Impact of Oral Health Status on Postoperative Complications and Functional Recovery After Cardiovascular Surgery

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada

  Mar. 2021, CJC Open, 3(3) (3), 276 - 284

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement.

  Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Kenji Okada, Ken-Ichi Hirata

  Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.

  Feb. 2021, Heart and vessels, 36(8) (8), 1234 - 1245, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between oral health and physical frailty in patients with cardiovascular disease

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Yoshitada Sakai, Masaya Akashi, Ken-ichi Hirata

  Elsevier BV, Aug. 2020, Journal of Cardiology

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• サルコペニアを有する心不全患者における身体活動量と健康関連QOLの特性

  小川真人, 井澤和大, 小林成美, 後竹康子, 坪井康典, 小槇公大, 桶本翔吾, 吉田尚史, 丸山孝樹, 酒井良忠, 平田健一

  2020, 国立大学リハビリテーション療法士学術大会誌, in press, Japanese

  [Refereed]


• Effects of acute-phase multidisciplinary rehabilitation on unplanned readmissions after cardiac surgery.

  Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Kumiko Wakida, Yasuko Gotake, Kazuhiro P Izawa, Yoshitada Sakai, Kenji Okada

  OBJECTIVES: The provision of inpatient programs that reduce the incidence of readmission after cardiac surgery remains challenging. Investigators have focused on multidisciplinary cardiac rehabilitation (CR) because it reduces the postoperative readmission rate; however, most previous studies used outpatient models (phase II CR). We retrospectively investigated the effect of comprehensive multidisciplinary interventions in the acute inpatient phase (phase I CR) on unplanned hospital readmission. METHODS: In a retrospective cohort study, we compared consecutive patients after cardiac surgery. We divided them into the multidisciplinary CR (multi-CR) group or conventional exercise-based CR (conv-CR) group according to their postoperative intervention during phase I CR. Multi-CR included psychological and educational intervention and individualized counseling in addition to conv-CR. The primary outcome was unplanned readmission rates between the groups. A propensity score-matching analysis was performed to minimize selection biases and the differences in clinical characteristics. RESULTS: In our cohort (n = 341), 56 (18.3%) patients had unplanned readmission during the follow-up period (median, 419 days). Compared with the conv-CR group, the multi-CR group had a significantly lower unplanned readmission rate (multivariable regression analysis; hazard ratio, 0.520; 95% confidence interval, 0.28-0.95; P = .024). A Kaplan-Meier analysis of our propensity score-matched cohort showed that, compared with the conv-CR group, the multi-CR group had a significantly lower incidence of readmission (stratified log-rank test, P = .041). CONCLUSIONS: In phase I, compared to conv-CR alone, multi-CR reduced the incidence of unplanned readmission. Early multidisciplinary CR can reduce hospitalizations and improve long-term prognosis after cardiac surgery.

  Dec. 2019, The Journal of thoracic and cardiovascular surgery, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of preoperative amino acid supplements on postoperative physical function and complications in open heart surgery patients: A study protocol for a randomized controlled trial.

  Masato Ogawa, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Kodai Komaki, Kumiko Wakida, Yasuko Gotake, Takeshi Inoue, Hiroshi Tanaka, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Michiko Takahashi, Wataru Ogawa, Ken-Ichi Hirata

  BACKGROUND: Elderly patients undergoing cardiac surgery often show poor nutritional status, muscle wasting, and sarcopenia, which are reported to affect postoperative functional recovery and incidence of complications. Amino acids are essential in maintaining nutritional status, synthesizing muscle protein, and promoting beneficial energy balance of the heart muscle. β-Hydroxy β-methylbutyric acid (HMB) is a leucine metabolite known to increase muscle protein synthesis and inhibit protein catabolism; it has been used to more effectively support patients with muscle wasting due to wearing diseases. However, the efficacy of amino acid administration comprising HMB in patients undergoing open heart surgery remains unclear. This study aims to examine whether preoperative short-term aggressive amino acid administration helps support postoperative recovery of physical function and prevent complications. METHODS: This is a single-center prospective randomized controlled trial (UMIN000030490). Patients aged ≥65 years who will be hospitalized for medical examination before cardiac surgery will be recruited. The participants will be randomly assigned to the experimental or control group. The experimental group will be administered with an amino acid supplement with HMB 1200mg, l-glutamine 7000mg, and l-arginine 7000mg once or twice per day depending on the degree of renal dysfunction, for 14-28 days preoperatively. The control group will not receive any nutritional intervention. The main outcome will be a change in the 6-min walking test distance pre- and postoperatively as a sign of functional recovery. Secondary outcomes such as the incidence of complications; physical, nutritional, and psychological states; mortality; and length of hospital stay will also be evaluated. CONCLUSION: This clinical study will determine the effects of preoperative short-term oral amino acid supplementation with HMB, l-glutamine, and l-arginine on postoperative physical function in elderly patients undergoing cardiac surgery.

  Oct. 2019, Journal of cardiology, 74(4) (4), 360 - 365, English, International magazine

  [Refereed]

  Scientific journal


• Comparable Effects of Pulmonary Endarterectomy and Balloon Pulmonary Angioplasty on Health-Related Quality of Life in Patients with Chronic Thromboembolic Pulmonary Hypertension.

  Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Taniguchi Y, Kinutani H, Tsuboi Y, Izawa KP, Satomi-Kobayashi S, Otake H, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata KI

  2019, Circulation Reports, 1(5) (5), 228 - 234, English

  [Refereed]

  Scientific journal


• Effects of postoperative dietary intake on functional recovery of patients undergoing cardiac surgery

  Ogawa M, Izawa KP, Kobayashi Seimi, Tsuboi Y, Komaki K, Gotake Y, Yoshida N, Wakida K, Uchida J, Sakai Yoshitada, Okita Y

  Jan. 2019, Nutr Metab Cardiovasc Dis, 29(1) (1), 90 - 96, English

  [Refereed]

  Scientific journal


• 初期臨床研修医を対象としたSOC(Sense of Coherence)によるレジリエンス測定とストレス対処能力自己評価

  木村真希, 在間梓, 坂口一彦, 伊藤智雄, Maniwa Yoshimasa, 河野誠司, Kobayashi Seimi

  Jul. 2018, 医学教育, 49(Suppl.) (Suppl.), 236, Japanese

  [Refereed]

  Scientific journal


• 高齢者における大動脈弁狭窄症術式別の栄養評価

  内田絢子, 小槇公大, 小川真人, 坪井康典, 脇田久美子, 山本育子, 高橋路子, Ogawa Wataru, Kobayashi Seimi, 宇佐美眞

  Jun. 2018, 日本病態栄養学会誌, 21(2) (2), 385 - 393, Japanese

  [Refereed]

  Scientific journal


• Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension.

  Yanaka K, Nakayama K, Shinke T, Shinkura Y, Taniguchi Y, Kinutani H, Tamada N, Onishi H, Tsuboi Y, Satomi-Kobayashi Seimi, OTAKE HIROMASA, Tanaka H, Okita Y, Emoto N, Hirata Ken-ichi

  BACKGROUND: Residual symptoms after pulmonary endarterectomy (PEA) remain as the clinical issues to be solved. Additional balloon pulmonary angioplasty (BPA) after PEA showed its efficacy with symptoms in a case series, although long-term spontaneous recovery of exercise ability after PEA was also reported. However, no studies have validated the clinical efficacy of additional BPA by directly comparing PEA with and without BPA. The aim of this study was to retrospectively evaluate the efficacy of additional BPA as a sequential hybrid therapy for chronic thromboembolic pulmonary hypertension after PEA. METHODS AND RESULTS: Among 44 patients with chronic thromboembolic pulmonary hypertension, 20 patients had residual symptoms after PEA. Of those, 10 patients underwent additional BPA (hybrid group) and were compared with the other 10 patients, who were followed up without BPA (PEA group). The period from PEA to additional BPA was 7.3±2.3 months. In hybrid group, mean pulmonary arterial pressure was significantly improved by PEA (40.6±1.8 to 26.9±3.1 mm Hg, P=0.001) and improved further (to 16.7±1.8 mm Hg, P=0.002) with additional BPA, which resulted in remarkable improvement in World Health Organization (WHO) functional class (pre- to post-BPA: class I/II/III/IV, 0/5/4/1 to 7/3/0/0; P<0.001). Compared with the PEA group at follow-up, the hybrid group achieved better mean pulmonary arterial pressure (18.7±1.7 versus 30.2±3.2 mm Hg, P=0.008), WHO functional class (class I/II/III/IV, 7/3/0/0 versus 0/8/2/0; P=0.001), and 6-minute walking distance (429±38 versus 319±22 m, P=0.028). CONCLUSIONS: A sequential hybrid strategy improved residual symptoms and exercise capacity compared with single-PEA therapy.

  Jun. 2018, J Am Heart Assoc., 7(13) (13), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension.

  Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Tsuboi Y, Izawa KP, Satomo-Kobayashi Seimi, Otake Hiromasa, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata Ken-ichi

  Jun. 2018, JACC Cardiovasc Interv., 11(11) (11), 1114 - 1116, English

  [Refereed]

  Scientific journal


• Anti-mitochondrial M2 Antibodies and Myopathy: Author's Reply.

  Hiroki Konishi, Koji Fukuzawa, Shumpei Mori, Seimi Satomi-Kobayashi, Kunihiko Kiuchi, Atsushi Suzuki, Tomomi Akita, Yoshihiko Yano, Akihiro Yoshida, Ken-Ichi Hirata

  Apr. 2018, Internal medicine (Tokyo, Japan), 57(8) (8), 1189 - 1189, English, Domestic magazine

  [Refereed]

  Scientific journal


• 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング

  岡野光真, Hara Tetsuya, 渡部晃一, 尾下寿彦, 津田成康, 入野康宏, 小林成美, 篠原正和, 杜隆嗣, 石田達郎, 平田健一

  日本臨床分子医学会, Apr. 2018, 日本臨床分子医学会学術総会プログラム・抄録集 55回, 55回, 58 - 58, Japanese


• Extensive revascularisation by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond haemodynamic normalisation

  Yuto Shinkura, Kazuhiko Nakayama, Kenichi Yanaka, Hiroto Kinutani, Naoki Tamada, Yasunori Tsuboi, Seimi Satomi-Kobayashi, Hiromasa Otake, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata

  EuroPCR, Apr. 2018, EuroIntervention, 13(17) (17), 2060 - 2068, English

  [Refereed]

  International conference proceedings


• 再構成HDLのphospholipid組成はその抗炎症作用に影響する(Phospholipid Composition of Reconstitute High Density Lipoproteins Affects Their Anti-inflammatory Effects)

  岡野 光真, 入野 康宏, 篠原 正和, 田中 伸明, 尾下 寿彦, 津田 成康, 渡部 晃一, 森 健太, 原 哲也, 小林 成美, 杜 隆嗣, 石田 達郎, 平田 健一

  (一社)日本循環器学会, Mar. 2018, 日本循環器学会学術集会抄録集, 82回, PJ015 - 1, English


• Preoperative exercise capacity is associated with the prevalence of postoperative delirium in elective cardiac surgery.

  Masato Ogawa, Kazuhiro P Izawa, Seimi Satomi-Kobayashi, Aki Kitamura, Yasunori Tsuboi, Kodai Komaki, Rei Ono, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita

  BACKGROUND: Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial but has not been fully explored. AIMS: The aim of this study was to determine the predictive value of the assessment of preoperative exercise capacity for POD. METHODS: We enrolled 313 consecutive patients (mean age, 68.6 ± 14.8 years) undergoing elective cardiac surgery. We measured physical functions such as the 6-minute walking distance (6MWD) and Timed Up-and-Go test (TUG) before surgery. The assessment of delirium was conducted every 8 h from the day of surgery to 5 days after surgery using the Intensive Care Delirium Screening Checklist. RESULTS: POD occurred in 46 patients (14.6%). Age, 6MWD, TUG, serum hemoglobin, estimated glomerular filtration rate, and length of intensive care unit stay were significantly different based on the presence or absence of POD (p < 0.05 for each). After multivariate analysis, 6MWD remained a statistically significant indicator for developing POD (OR 0.98; p = 0.02). The cut-off value of 6MWD for predicting POD was 345 m (AUC = 0.75; p = 0.001). CONCLUSIONS: Poor exercise capacity was found to be an independent predictor of POD following elective cardiac surgery. This finding suggests the importance of preoperative functional evaluation in the prevention and management of POD in cardiac surgery patients.

  Jan. 2018, Aging clinical and experimental research, 30(1) (1), 27 - 34, English, International magazine

  [Refereed]

  Scientific journal


• 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討

  脇田久美子, 三ヶ尻礼子, 田渕聡子, 山西美沙, 赤毛弘子, 玉田萌子, 西田ひかる, 中谷早希, 金谷沙紀, 森智子, 向山万為子, 中村美仁, 山本育子, 松田佳子, 高橋路子, 小川渉, Kobayashi Seimi, 石田達郎, 大瀬良知子, 栗原伸公

  Jan. 2018, 日本病態栄養学会誌, 21(Supple) (Supple), 125, Japanese

  Symposium


• Impact of delirium on postoperative frailty and long term cardiovascular events after cardiac surgery

  Masato Ogawa, Kazuhiro P. Izawa, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Kodai Komaki, Yasuko Gotake, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita

  Public Library of Science, Dec. 2017, PLoS ONE, 12(12) (12), e0190359., English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Associations of Exercise Tolerance With Hemodynamic Parameters for Pulmonary Arterial Hypertension and for Chronic Thromboembolic Pulmonary Hypertension

  Yasunori Tsuboi, Hidekazu Tanaka, Ryo Nishio, Takuma Sawa, Daisuke Terashita, Kazuhiko Nakayama, Seimi Satomi-Kobayashi, Yoshitada Sakai, Noriaki Emoto, Ken-ichi Hirata

  Sep. 2017, JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 37(5) (5), 341 - 346, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Necl-4 enhances the PLC gamma-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2

  Shota Yamana, Amina Tokiyama, Hidenobu Fujita, Yuya Terao, Sayo Horibe, Naoto Sasaki, Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yoshiyuki Rikitake

  Aug. 2017, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(2) (2), 169 - 175, English

  [Refereed]

  Scientific journal


• Extensive revascularization by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond hemodynamic normalization

  ShinkuraY, Nakayama Kazuhiko, YanakaK, KinutaniH, TamadaN, TsuboiY, Kobayashi Seimi, OtakeH, ShinkeT, EmotoN, Hirata Ken-ichi

  Aug. 2017, EuroIntervention, English

  [Refereed]

  Scientific journal


• Interaction of FAM5C with UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1): Implication of N-glycosylation in FAM5C secretion

  Yuya Terao, Hidenobu Fujita, Sayo Horibe, Junya Sato, Satomi Minami, Miwako Kobayashi, Ichiro Matsuoka, Naoto Sasaki, Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yoshiyuki Rikitake

  May 2017, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 486(3) (3), 811 - 816, English

  [Refereed]

  Scientific journal


• 開心術後患者における退院時身体機能と主要有害心血管イベントとの関連

  小槇 公大, 小林 成美, 小川 真人, 坪井 康典, 井澤 和大, 後竹 康子, 寺下 大輔, 田中 裕史, 酒井 良忠, 平田 健一, 大北 裕

  (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, CO - 10, Japanese


• Changes in Exercise Capacity and Psychosocial Factors in Hospitalized Cardiac Surgery Patients

  IZAWA P. KAZUHIRO

  2017, Research in Cardiovascular Medicine, 6(4) (4), 38 - 44, English

  [Refereed]

  Scientific journal


• Poor preoperative nutritional status is an important predictor of the retardation of rehabilitation after cardiac surgery in elderly cardiac patients

  Ogawa M, Izawa KP, Satomi-Kobayashi Seimi, Kitamura A, Ono R, SAKAI YOSHITADA, Okita Y

  2017, Aging Clinical Experimental Research, 29(2) (2), 283 - 290., English

  [Refereed]

  Scientific journal


• Anti-mitochondrial M2 Antibodies Enhance the Risk of Supraventricular Arrhythmias in Patients with Elevated Hepatobiliary Enzyme Levels

  Hiroki Konishi, Koji Fukuzawa, Shumpei Mori, Seimi Satomi-Kobayashi, Kunihiko Kiuchi, Atsushi Suzuki, Yoshihiko Yano, Akihiro Yoshida, Ken-ichi Hirata

  2017, INTERNAL MEDICINE, 56(14) (14), 1771 - 1779, English

  [Refereed]

  Scientific journal


• 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium

  Irino Yasuhiro, Toh Ryuji, NagaoM, MoriT, HonjoT, ShinoharaM, TsudaS, NakajimaH, Kobayashi Seimi, ShinkeT, Tanaka Hidekazu, Ishida Tatsuro, MiyataO, Hirata Ken-ichi

  Nov. 2016, Sci Rep, 6, 36749, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Serum phosphate is an independent predictor of the total aortic calcification volume in non-hemodialysis patients undergoing cardiovascular surgery

  Mitsuo Kinugasa, Shumpei Mori, Tomofumi Takaya, Tatsuro Ito, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sei Fujiwara, Tatsuya Nishii, Atsushi K. Kono, Yutaka Okita, Ken-ichi Hirata

  Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Oct. 2016, Journal of Cardiology, 68(4) (4), 308 - 315, English

  [Refereed]

  Scientific journal


• β-Hydroxybutyrate elevation as a compensatory response against oxidative stress in cardiomyocytes

  NagaoM, Toh Ryuji, Irino Yasuhiro, MoriT, NakajimaH, Hara Tetsuya, HonjoT, Kobayashi Seimi, ShinkeT, TanakaH, Ishida Tatsuro, Hirata Ken-ichi

  Jul. 2016, Biochem Biophys Res Commun, 475(4) (4), 322 - 8, English

  [Refereed]

  Scientific journal


• Cardiac Rehabilitation and Assessment of Exercise Capacity in the Treatment of Pulmonary Hypertension: Suggestions for Long-term Intervention from Diagnosis to Recovery Phase

  IZAWA P. KAZUHIRO

  日本心臓リハビリテーション学会 ; [1996]-, 2016, 心臓リハビリテーション, 21(4) (4), 164 - 169, Japanese

  [Refereed]

  Scientific journal


• Preoperative physical activity in relation to postoperative delirium in elective cardiac surgery patients

  OgawaM, IzawaKP, KitamuraA, OnoR, Kobayashi Seimi, Sakai Yoshitada, OkitaY

  Dec. 2015, Int J Cardiol, 201, 154 - 6, English

  [Refereed]

  Scientific journal


• Involvement of Rho-associated protein kinase (ROCK) and bone morphogenetic protein-binding endothelial cell precursor-derived regulator (BMPER) in high glucose-increased alkaline phosphatase expression and activity in human coronary artery smooth muscle c

  TeraoY, Kobayashi Seimi, Hirata Ken-ichi, RikitakeY

  Aug. 2015, Cardiovasc Diabetol, 14, 104, English

  [Refereed]

  Scientific journal


• Three-dimensional quantification and visualization of aortic calcification by multidetector-row computed tomography: A simple approach using a volume-rendering method

  Mori S, Takaya Tomofumi, Kinugasa M, Ito T, Takamine S, Fujiwara S, Nishii Tatsuya, Kono AK, Inoue T, Kobayashi Seimi, Rikitake Yoshiyuki, Okita Y, Hirata Ken-ichi

  Apr. 2015, Atherosclerosis, 239(2) (2), 622 - 8, English

  [Refereed]

  Scientific journal


• Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation

  Sato J, Kinugasa M, Kobayashi Seimi, Hatakeyama K, Knox AJ, Asada Y, Wierman ME, Hirata Ken-ichi, Rikitake Yoshiyuki

  Sep. 2014, PLoS One, 9(9) (9), e107236, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Nectin-Like Molecule-5 Regulates Intimal Thickening After Carotid Artery Ligation in Mice

  Kureha F, Kobayashi Seimi, Kubo Y, Kinugasa M, Ishida Tatsuro, Takai Yoshimi, Hirata Kenichi, Rikitake Yoshiyuki

  Jun. 2013, Arterioscler Thromb Vasc Biol, 33(6) (6), 1206 - 11, English

  [Refereed]

  Scientific journal


• Endothelial lipase modulates pressure overload-induced heart failure through alternative pathway for Fatty Acid uptake

  Nakajima H, Ishida Tatsuro, Satomi-Kobayashi Seimi, Mori K, Hara T, Sasaki Naoto, Yasuda T, Toh Ryuji, Tanaka Hidekazu, Kawai H, Hirata Kenichi

  May 2013, Hypertension, 61(5) (5), 1002 - 7, English

  [Refereed]

  Scientific journal


• Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER)

  Kobayashi Seimi, Ishida Tatsuro, Takai Yoshimi, Hirata Kenichi, Rikitake Yoshiyuki

  Aug. 2012, J Biol Chem, 287(36) (36), 30336 - 45, English

  [Refereed]

  Scientific journal


• Necl-5/Poliovirus Receptor Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis

  Kinugasa M, Amano H, Kobayashi Seimi, Nakayama Kazuhiko, Miyata Muneaki, Kubo Y, Nagamatsu Y, Kurogane Y, Kureha F, Yamana S, Hirata Kenichi, Miyoshi J, Takai Yoshimi, Rikitake Yoshiyuki

  Mar. 2012, Circulation research, 110(5) (5), 716 - 26, English

  [Refereed]

  Scientific journal


• Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis

  Tawa H, Rikitake Yoshiyuki, Takahashi M, Amano H, Miyata Muneaki, Kobayashi Seimi, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata Ken-ichi, Takai Yoshimi

  Jun. 2010, Circ Res, 106(11) (11), 1731 - 42, English

  [Refereed]

  Scientific journal


• Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload

  Kobayashi Seimi, Takai Yoshimi

  Oct. 2009, Hypertension, Vol. 54, No. 4, pp. 825-31, English

  [Refereed]

  Scientific journal


• Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction

  Yamashita Tomoya, Shinohara Masakazu, Kobayashi Seimi, Toh Ryuji, Sugiyama Daisuke, Nishimura Kunihiro, Hirata Kenichi

  May 2009, Circulation journal, Vol. 73, No. 5, pp. 955-62, English

  [Refereed]

  Scientific journal


• Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase

  Toh Ryuji, Kobayashi Seimi, Shinohara Masakazu, Yamashita Tomoya, Hirata Kenichi

  Sep. 2008, Circulation journal, Vol. 72, No. 9, pp. 1512-9, English

  [Refereed]

  Scientific journal

• 酸化ストレスに対するα-ケトグルタル酸の心筋細胞保護作用

  渡部 晃一, 杜 隆嗣, 西森 誠, 岡野 光真, 入野 康宏, 原 哲也, 篠原 正和, 小林 成美, 石田 達郎, 平田 健一

  (一社)日本心臓病学会, Sep. 2019, 日本心臓病学会学術集会抄録, 67回, P - 206, Japanese


• HDL機能性の新しい指標であるコレステロール取り込み能とコレステロール排出能の冠動脈プラーク特性に関連した比較(Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL-functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties)

  尾下 寿彦, 杜 隆嗣, 岡野 光真, 渡部 晃一, 西森 誠, 永野 雄一朗, 原田 周, 村上 克洋, 桐山 真利亜, 吉川 景子, 三輪 桂子, 小林 成美, 篠原 正和, 原 哲也, 入野 康宏, 大竹 寛雅, 石田 達郎, 平田 健一

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, PJ100 - 3, English


• Modulation of high-density lipoprotein function via cardiac rehabilitation

  Seimi Satomi-Kobayashi, Tatsuro Ishida

  Japan Atherosclerosis Society, 2018, Journal of Atherosclerosis and Thrombosis, 25(2) (2), 128 - 130, English

  [Refereed]

  Introduction scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【最新冠動脈疾患学(上)-冠動脈疾患の最新治療戦略-】 冠動脈疾患の発症予測と早期治療介入の現状と課題

  小林成美, Hirata Ken-ichi

  Jun. 2016, 日本臨床, 74(増刊4 最新冠動脈疾患学(上)) (増刊4 最新冠動脈疾患学(上)), 19 - 24, Japanese

  [Invited]

  Introduction commerce magazine


• [Predictive diagnosis and early therapeutic intervention for coronary artery disease: current status and issues]

  Kobayashi Seimi, HirataKI

  Jun. 2016, Nihon Rinsho, 74(Suppl 4 Pt 1) (Suppl 4 Pt 1), 19 - 24, English

  Introduction commerce magazine


• 【災害医療と血圧管理】 災害後の慢性期における血圧管理

  Kobayashi Seimi, Hirata Kenichi

  Aug. 2011, 血圧, 18巻, 8号, pp. 761-764, Japanese

  Introduction scientific journal


• 免疫グロブリン様分子Necl‐5による血管新生の制御

  宮田宗明, 力武良行, 天野恭志, 衣笠允雄, 小林成美, 永松裕一, 武田匡史, 三好淳, 平田健一, 高井義美

  2010, 生化学, ROMBUNNO.1P-0477, Japanese

• 今日の治療指針 2019年版 / 6.循環器疾患 無症候性心筋虚血

  Kobayashi Seimi

  Others, 医学書院, Jan. 2019, Japanese

  General book


• 今日の治療指針 2018年版 / ６．循環器疾患 「心臓神経症 Cardiac Neurosis」

  Kobayashi Seimi

  Others, 医学書院, Jan. 2018, Japanese

  General book


• 5. 日本臨牀2016年6月増刊号 最新冠動脈疾患学（上）－冠動脈疾患の最新治療戦略－ / 総論 ３．冠動脈疾患の発症予測と早期治療介入の現状と課題

  Kobayashi Seimi, 平田健一

  Others, 日本臨牀社, Jun. 2016, Japanese

  Scholarly book


• 心臓リハビリテーション / 肺高血圧症治療における心臓リハビリテーションと運動耐容能評価 診断時から回復期にわたる長期介入への提言

  坪井康典, 田中秀和, Kobayashi Seimi, 佐和琢磨, 寺下大輔, 絹谷洋人, 中山和彦, 井澤和大, 酒井良忠, 江本憲昭, 平田健一

  Others, 日本心臓リハビリテーション学会, Apr. 2016, Japanese

  Scholarly book


• 今日の治療指針 私はこう治療している 2015 / 高安動脈炎（大動脈症候群、脈なし病）

  Kobayashi Seimi

  Others, 医学書院, 2015, Japanese

  General book


• 心不全診療Q&A エキスパート106人からの回答 / II.心不全診療Q&A ５．慢性心不全の薬物療法 (8)β遮断薬を入れるタイミングはどのように考えたらよいですか？ (9)β遮断薬を増量する目安には何を用いればよいでしょうか？ (10)β遮断薬はどれくらいまで増量すべきでしょうか？

  Kobayashi Seimi, Hirata Kenichi

  Others, 中外医学社, Sep. 2012, Japanese

  General book


• 循環器疾患最新の治療2012-2013 / XVI その他、4 Raynaud 現象

  Kobayashi Seimi

  Others, 南江堂, Mar. 2012, Japanese

  Scholarly book


• 1. 日本臨牀65巻増刊号4 心不全（上）－最新の基礎・臨床研究の進歩－ / IV．成因病態に関する基礎的研究、3．サイトカインによる心筋細胞肥大・線維化・炎症惹起の機序、1）TN-α

  Kobayashi Seimi, 川嶋成乃亮

  Others, 日本臨牀社, 2007, Japanese

  Scholarly book

• Novel Deep Venous Thrombosis Model Enabled Visualization of Thrombus Formation and Organization Process in vivo.

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Method: We established a novel murine DVT model, suitable for real-time in vivo imaging. Thr, Domestic conference

  Oral presentation


• Evaluation of Microvasculopathy using Dual-Energy CT in Chronic Thromboembolic Pulmonary Hypertension

  Hiroyuki Onishi, Yu Taniguchi, Yoichiro Matsuoka, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yasunori Tuboi, Shumpei Mori, Kazuhiko Nakayama, Hiromasa Otake, Seimi Satomi-Kobayashi, EMOTO NORIAKI, Kenichi Hirata

  第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference

  Poster presentation


• Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata

  第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the procedures require cultured cells and are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol uptake capacity (, Domestic conference

  Poster presentation


• 心臓リハビリテーション多職種協働介入による再入院予防効果の検証

  石井 裕輝, 宇賀慶子, 髙濱和美, 小槇公大, 小川真人, 坪井康典, 西田ひかる, 脇田久美子, GOTAKE YASUKO, Satomi-Kobayashi Seimi, HIRATA KENICHI

  第4回日本心臓リハビリテーション学会近畿地方会, Feb. 2019, Japanese, 京都, Domestic conference

  Oral presentation


• K君の物語

  MATSUMOTO KENSUKE, Satomi-Kobayashi Seimi, HIRATA KENICHI

  第4回日本心臓リハビリテーション学会近畿地方会, Feb. 2019, Japanese, 日本心臓リハビリテーション学会, 京都, 神戸大学で経験した心臓病緩和の物語。, Domestic conference

  [Invited]

  Nominated symposium


• Comparison of Clinical Utility Between Cholesterol Uptake Capacity, a Novel Indicator of HDL Functionality, and Cholesterol Efflux Capacity

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata

  第35回 国際心臓研究学会日本部会, Dec. 2018, English, 国際心臓研究学会日本部会, 東京, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, Domestic conference

  Poster presentation


• 新規マウス血栓モデルによるDVT生体イメージング

  岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI

  第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景: 担癌患者では血栓形成傾向による静脈血栓症の合併が多いが、深部静脈血栓症(DVT)の詳細な機序は未だに不明である。血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンを伴う赤色血栓であり、ヒトDVTに病態生理学的に類似する。また好発部位である静脈弁に血栓が形成されやすく、血栓溶解や血栓塞栓子遊離の観察も可能である。血栓形成時には赤血球凝集が先行し、既存の, Domestic conference

  Oral presentation


• 高比重リポタンパクによる酸化ストレスに対する心保護作用は PI3K/mTOR シグナリング経路を介する

  渡部晃一, TOH RYUJI, 西森誠, 岡野光真, 尾下寿彦, 林友鴻, 長尾学, IRINO YASUHIRO, HARA TETSUYA, SHINOHARA MASAKAZU, Satomi-Kobayashi Seimi, ISHIDA TATSURO, HIRATA KENICHI

  第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景：高比重リポタンパク (High-density lipoprotein；HDL) は心血管系に対して多面的な効果を有することが知られている。HDLがドキソルビシンによる活性酸素種の生成を介した心筋障害から細胞保護効果を示すことが報告されているが、心筋細胞に対して及ぼす直接的な影響は十分に明らかにされていない。目的：HDLが酸化ストレス下において心筋細胞へ及ぼす効果を検証する。方法と結果：H9C2細胞に対して、HDLによる前処理を加えた後にH2O2 による酸化ストレス刺激を加えると、HDLの容量依存性に細胞保護効果を示すことを明らかにした。HDLによる処理は、H9C2細胞のAktのリン酸化を有意に増加させ、一方PI3K阻害剤であるLY294002、mTOR阻害剤であるラパマイシンを投与することにより、Aktのリン酸化ならびにHDLの有する抗アポト, Domestic conference

  Oral presentation


• Reduction of 5-Lipoxygenase Derived Docosahexaenoic Acid Metabolites Under Social Mental Stress: Their Function for Maintenance of Heme Oxygenase-1 Expression in Macrophage

  Makoto Nishimori, Masakazu Shinohara, Kouichi Watanabe, Mitsumasa Okano, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  American Heart Association's 2018 Scientific Sessions, Nov. 2018, English, シカゴ, Epidemiological studies reveal an association between social mental stresses and incidence of cardiovascular disease. Although hyperactivation of sympathetic nerve system is reported to induce systemic inflammation, little is known regarding precise mechanisms how social mental stress induces systemic inflammation and cardiovascular events. We have developed liquid chromatograp, International conference

  Poster presentation


• Establishment of Novel Deep Venous Thrombosis Model Suitable for in vivo Imaging

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Backgrounds: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the ro, International conference

  Oral presentation


• Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid Burden

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata

  American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, International conference

  Poster presentation


• Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension

  Hiroyuki Onishi, Kazuhiko Nakayama, Kenichi Yanaka, Noaki Tamada, Yu Izawa, Yuto Shinkura, Syunsuke Shimoyama, Tatsuya Nishii, Atsushi Kono, Shumpei Mori, Hiromasa Otake, Seimi Satomi-Kobayashi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata

  ESC Congress 2018, Aug. 2018, English, European Sciety of Cardiology, ミュンヘン, International conference

  Poster presentation


• Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension

  Hiroyuki Onishi, Kazuhiko Nakayama, Ken-ichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Hiromasa Otake, Satomi-Kobayashi Seimi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata

  EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference

  Poster presentation


• Searching for modulating factor of cholesterol uptake capacity, a novel indicator for HDL functionality

  Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Shigeyasu Tsuda, Koichi Watanabe, Satomi-Kobayashi Seimi, Tetsuya Hara, Masakazu Shinohara, Yasuhiro Irino, Katsuhiro Murakami, Amane Harada, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). CUC could be an indicator of HDL function for coronary risk stratification. In this study, we sought to identify modulating factors of CUC. Methods: We used nu, Domestic conference

  Poster presentation


• Real-Time in Vivo Imaging of Thrombosis Initiated by Red Blood Cell Aggregation in Novel Murine Stasis Model of DVT

  Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Shigeyasu Tsuda, Kenta Mori, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Stasis is a major cause of DVT (deep venous thrombosis) formation. IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the roles of platelets and leukocytes in the initiation of DVT, but they are mainly caused by endothelial injury, Domestic conference

  Poster presentation


• Novel murine deep venous thrombosis (DVT) model enables real-time in vivo imaging of clinically relevant DVT.

  Mitsumasa Okano, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata

  International Academy of Cardiology Annual Scientific Sessions 2018 23rd World Congress on Heart Disease, Jul. 2018, English, International Academy of Cardiology, ボストン, Background: The pathogenesis of deep venous thrombosis (DVT) is still unclear, largely due to a lack of an adequate animal model. Although stasis is a major cause of DVT formation, inferior vena cava stasis model is not suitable for in vivo imaging because of its deep location. Other thrombosis models allowing in vivo imaging such as FeCl3 and laser injury induce platelet throm, International conference

  Oral presentation


• Impact of Delirium on Postoperative Frailty and Cardiovascular Events after Cardiac Surgery.

  Masato Ogawa, Kazuhiro P Izawa, Seimi-Satomi Kobayashi, Yasunori Tsuboi, Kodai Komaki, Yasuko Gotake, Hiroshi Tanaka, Kenichi Hirata, Yoshitada Sakai, Yutaka Okita

  第24回日本心臓リハビリテーション学会学術集会, Jul. 2018, English, 日本心臓リハビリテーション学会, 横浜, Domestic conference

  Oral presentation


• 不整脈および左室収縮機能障害を合併した、抗ミトコンドリアM2抗体陽性筋炎の1例

  竹本 良, MATSUMOTO KENSUKE, 柴田 奈緒, 黒田 浩史, Satomi-Kobayashi Seimi, TANAKA HIDEKAZU, HIRATA KENICHI, SEKIGUCHI KENJI, Quan Yang

  第126回 日本循環器学会近畿地方会, Jun. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング

  岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, 津田 成康, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI

  第55回 日本臨床分子医学会学術集会, Apr. 2018, Japanese, 日本臨床分子医学会, 京都, 背景: 血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間・空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による励起光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンネットワークを伴う赤色血栓であり、ヒトDVTに病理生態学的に類似する。また好発部位である静脈弁や血管合流部など血流鬱滞部が起始部になりやすい。血栓形成時には赤血球凝集が先行し、内皮傷害血栓モデルに見られる血小板や白血球は目立たず、フィブリンとともに遅れて集積して器質化する。器質化の程度によって、, Domestic conference

  Poster presentation


• Treatment goal of BPA would be extensive perfusion recovery beyond hemodynamic normalization

  Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  第82回 日本循環器学会学術集会, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference

  Poster presentation


• In Vivo Imaging Revealed Platelet- and Leukocyte- independent Initiation of Deep Venous Thrombosis (DVT) in Novel Murine DVT Model

  Mitsumasa Okano, Hara Tetsuya, Toshihiko Oshita, Shigeyasu Tsuda, Koichi Watanabe, Kobayashi Seimi, Irino Yasuhiro, Shinohara Masakazu, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Although past reports showed the role of platelets and leukocytes in the initiation of DVT, the underlying mechanism is not fully understood.Method: We established a novel DVT model, suitable for in vivo imaging; DVT can be formed and visualiz, Domestic conference

  Poster presentation


• Identification of Determinants of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality

  Toshihiko Oshita, Toh Ryuji, Mitsumasa Okano, Shigeyasu Tsuda, Ko-ichi Watanabe, Kobayashi Seimi, Hara Tetsuya, Shinohara Masakazu, Irino Yasuhiro, Katsuhiro Murakami, Amane Harada, Ishida Tatsuro, Hirata Ken-ichi

  The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC), and demonstrated its feasibility f, Domestic conference

  Poster presentation


• 反復性肺炎に伴う肺高血圧症患者の人工呼吸器離脱に対して心リハが有効であった一例

  坪井 康典, Kobayashi Seimi, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi

  第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• 神戸大学における循環器医療連携の試み

  Kobayashi Seimi, Hirata Ken-ichi

  第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• 心血管外科手術周術期の口腔機能管理に関する臨床的検討

  難波渚, Akashi Masaya, Komori Takahide, 桶本翔吾, 小槇 公大, 小川 真人, 坪井 康典, Kobayashi Seimi, Gotake Yasuko, Okita Yutaka

  第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討

  内田 絢子, 脇田 久美子, 小槙 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, 宇佐美 眞

  第21回病態栄養学会年次学術集会, Feb. 2018, Japanese, 日本病態栄養学会, 京都, Domestic conference

  Oral presentation


• 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 赤毛 弘子, 大瀬良 知子, 栗原 伸公

  第3回 日本心臓リハビリテーション学会 近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Poster presentation


• 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山下 弘子, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公

  第3回日本心臓リハビリ―ション学会近畿支部地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Poster presentation


• サルコペニアを有する心不全患者における身体活動量と健康関連QOLの特性

  小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, 吉田 尚史, Sakai Yoshitada, Hirata Ken-ichi

  第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• TAVI患者におけるFrailtyが術後リハビリテーションに及ぼす影響

  小槇公大, Kobayashi Seimi, 井澤和大, 坪井康典, 小川真人, Gotake Yasuko, 吉田尚史, Sakai Yoshitada, Shinke Toshiro, Hirata Ken-ichi

  第3回 日本心臓リハビリテーション学会 近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference

  Oral presentation


• Sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.

  Kenichi Yanaka, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, Hiroyuki Kawamori, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yasunori Tsuboi, Kobayashi Seimi

  6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference

  Poster presentation


• Pulmonary Blood Volume by Dual-energy CT is a new management index for chronic thromboembolic pulmonary hypertension

  Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference

  Poster presentation


• Predictors for worsening hemodynamics during follow-up period after balloon pulmonary angioplasty

  Yuto Shinkura, Nakayama Kazuhiko, Hiroyuki Ohnishi, Kenichi Yanaka, Naoki Tamada, Yasunori Tsuboi, Kobayashi Seimi, Otake Hiromasa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference

  Poster presentation


• 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討

  脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 赤毛 弘子, 玉田 萌子, 西田 ひかる, 中谷 早希, 金谷 沙紀, 森 智子, 向山 万為子, 中村 美仁, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公

  第21回病態栄養学会年次学術集会, Jan. 2018, Japanese, 日本病態栄養学会, 京都, Domestic conference

  Oral presentation


• Pulmonary blood volume evaluated by dual-energy CT is a new maker for the management of chronic thromboembolic pulmonary hypertension

  Hiroyuki Onishi, Nakayama Kazuhiko, Ken-ichi Yanaka, Naoki Tamada, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  American Heart Association Scientific Sessions 2017, Nov. 2017, English, American Heart Association, アナハイム, USA, International conference

  Poster presentation


• PEA周術期におけるCTEPH患者に対する心臓リハビリテーション―術前運動耐容能評価が有用であった1例―

  坪井 康典, Kobayashi Seimi, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Tanaka Hiroshi, Okita Yutaka, Hirata Ken-ichi

  第126回日本循環器学会近畿地方会, Nov. 2017, Japanese, 日本循環器学会, 大阪, Domestic conference

  Oral presentation


• 肺高血圧症患者における唾液アミラーゼ亢進は運動耐容能低下を反映する

  坪井康典, SATOMI-KOBAYASHI SEIMI, 寺下大輔, 玉田直己, 小川真人, 小槇公大, NAKAYAMA KAZUHIKO, TANAKA HIDEKAZU, IZAWA P. KAZUHIRO, SAKAI YOSHITADA, EMOTO NORIAKI, HIRATA KENICHI

  第23回日本心臓リハビリテーション学会学術集会, Jul. 2017, Japanese, Domestic conference

  Oral presentation


• 大動脈弁狭窄症患者における基本チェックリストと従のフレイル評価および術後運動耐容能との関連

  小槇公大, 井澤和大, Kobayashi Seimi, Gotake Yasuko, 坪井康典, 小川真人, 寺下大輔, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka

  第23回日本心臓リハビリテーション学会 学術集会, Jul. 2017, Japanese, 日本心臓リハビリテーション学会, 岐阜, Domestic conference

  Poster presentation


• 術前サルコペニアは心臓術後合併症を予測する～CTによる筋量と身体機能を用いた検討～

  小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, Sakai Yoshitada, Hirata Ken-ichi, Tanaka Hiroshi, Okita Yutaka

  第23回日本心臓リハビリテーション学会学術集会, Jul. 2017, Japanese, 日本心臓リハビリテーション学会, 岐阜, Domestic conference

  Public symposium


• CTEPHに対するハイブリッド治療の有効性・安全性について

  谷仲 謙一, Nakayama Kazuhiko, 玉田 直己, 大西 裕之, 新倉 悠人, 坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, Shinke Toshiro, EMOTO NORIAKI, Hirata Ken-ichi

  第2回日本肺高血圧・肺循環学会学術集会, Jun. 2017, Japanese, 日本肺高血圧・肺循環学会, 札幌, Domestic conference

  Oral presentation


• Safety of Complete Revascularization of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension beyond Normalized Mean Pulmonary Arterial Pressure

  Yuto Shinkura, Nakayama Kazuhiko, Kenichi Yanaka, Yoshiro Tsukiyama, Hiroyuki Yamamoto, Yuichiro Nagano, Naoki Tamada, Yoshinori Nagasawa, Natsuko Tahara, Kenzo Uzu, Koji Kuroda, Yasunori Tsuboi, Daisuke Terashita, Hachidai Takahashi, Takayoshi Toba, Tanaka Hidekazu, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  第81回 日本循環器学会学術集会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference

  Poster presentation


• 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討

  内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto

  第32回日本静脈経腸栄養会年次学術集会, Feb. 2017, Japanese, 日本静脈経腸栄養学会, 岡山, Domestic conference

  Poster presentation


• 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討

  内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto

  The 32nd Annual Meeting of Japanese Society for Parenteral and Enteral Nutrition, Feb. 2017, Japanese, 日本静脈経腸栄養学会, 岡山, Domestic conference

  Poster presentation


• 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討

  内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto

  第20回日本病態栄養学会, Jan. 2017, Japanese, 日本病態栄養学会, 京都, Domestic conference

  Oral presentation


• 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討

  内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru

  第20回日本病態栄養学会年次学術集会, Jan. 2017, Japanese, 日本病態栄養学会, 京都, Domestic conference

  Oral presentation


• Compensatory Accumulation of Myocardial β-Hydroxybutyrate Accompanied by SCOT Downregulation in Response to Oxidative Stress

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi

  ISHR 2016, Dec. 2016, Japanese, International Society for Heart Research, 東京, Recent studies have shown that the ketone body -hydroxybutyrate (βOHB) acts not only as a carrier of energy but also as a signaling molecule that has a role in diverse cellular functions. Circulating βOHB levels have been previously reported to be increa, Domestic conference

  Oral presentation


• Compensatory Accumulation of βHydroxybutyrate Accompanied by SCOT Downregulation in Failing Hearts

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi

  American Heart Association Scientific sessions 2016, Nov. 2016, English, American Heart Association, New Orleans, USA, Background and ObjectiveCirculating levels of ketone bodies have been previously reported to be increased in patients with congestive heart failure (HF). Recent studies have shown that the ketone body β-hydroxybutyrate (βOHB) acts not only as a carrier of, International conference

  Poster presentation


• 圧正常化CTEPH患者に対する追加BPA効果の検討

  新倉 悠人, Nakayama Kazuhiko, 谷仲 謙一, 玉田 直己, 坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, Shinke Toshiro, 江本 憲昭, Hirata Ken-ichi

  Japanese Pulmonary Hypertension Society(JPHS)・Japanese Pulmonary Circulation Society(JPCS), Oct. 2016, Japanese, Japanese Pulmonary Hypertension Societ,Japanese Pulmonary Circulation Societ, 東京, Domestic conference

  Oral presentation


• Impact of Delirium on Postoperative Frailty and Long Term Cardiovascular Events after Cardiac Surgery

  Masato Ogawa, Kazuhiro Izawa, Kobayashi Seimi, Yasunori Tsuboi, Kodai Komaki, Gotake Yasuko, Tanaka Hiroshi, Hirata Ken-ichi, Sakai Yoshitada, Okita Yutaka

  The 20th Annual Scientific Meeting of the Japanese Heart Filure Society, Oct. 2016, Japanese, 日本心不全学会, 札幌, Domestic conference

  Oral presentation


• 心肺運動負荷試験結果に基づく運動療法は肺高血圧症患者の気分状態を即時的に改善させる

  坪井 康典, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Tanaka Hidekazu, 井澤 和大, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi

  The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, Japanese, 日本心臓リハビリテーション学会, 東京, Domestic conference

  Oral presentation


• 高度大動脈弁狭窄症患者における術後リハビリテーション進行に関わる要因についての検討

  小槇公大, 井澤和大, Kobayashi Seimi, Gotake Yasuko, 小川真人, 坪井康典, 佐和琢磨, 寺下大輔, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka

  The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, Japanese, 日本心臓リハビリテーション学会, 東京, Domestic conference

  Oral presentation


• Gait Speed Is a Predictor of Postoperative Delirium in Elderly Cardiac Surgery Patients

  小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, Sakai Yoshitada, 佐和 琢磨, Hirata Ken-ichi, Okita Yutaka

  The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, English, 日本心臓リハビリテーション学会, 東京, Domestic conference

  Oral presentation


• 待機的心臓手術患者において術前身体活動は術後せん妄を予測する

  小川 真人, 井澤 和大, 北村 アキ, Kobayashi Seimi, 小槇 公大, Ono Rei, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka

  The 51st Congress of Japanese Society of Physical Therapy, May 2016, Japanese, 日本理学療法士協会, 札幌, Domestic conference

  Oral presentation


• 肺動脈性肺高血圧症および慢性血栓塞栓性肺高血圧症患者に対する運動耐容能および血行動態評価として心肺運動負荷試験は有用である

  坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi

  The 80th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2016, Japanese, The Japanese Circulation Society, 仙台, Domestic conference

  Poster presentation


• 高齢開心術患者の術前6分間歩行距離は術後の自宅退院を予測する

  小槇 公大, Kitamura Aki, 小川 真人, 坪井 康典, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 井澤 和大, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka

  The 80th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2016, Japanese, The Japanese Circulation Society, 仙台, Domestic conference

  Oral presentation


• Examination of the correlation between Health Related Quality of Life scores and parameters from six-minute walk test in pulmonary hypertension

  Naoki Tamada, Nakayama Kazuhiko, Ken-ichi Yanaka, Yuto Shinkura, Yasunori Tuboi, Tanaka Hidekazu, Kobayashi Seimi, Kazuhiro Izawa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  第80回日本循環器学会総会, Mar. 2016, English, 日本循環器学会, 仙台, Domestic conference

  Oral presentation


• Characterization of the patients with sustained low oxygen saturation at one year after balloon pulmonary angioplasty.

  Nakayama Kazuhiko, Yuto Shinkura, Naoki Tamada, Ken-ichi Yanaka, Yasunori Tuboi, Tanaka Hidekazu, Kobayashi Seimi, Kazuhiro Izawa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi

  第80回日本循環器学会総会, Mar. 2016, English, 日本循環器学会, 仙台, Domestic conference

  Oral presentation


• 肺動脈内膜摘除術周術期における慢性血栓塞栓性肺高血圧症患者の身体機能について

  坪井 康典, Kobayashi Seimi, Kitamura Aki, 小川 真人, 小槇 公大, 佐和 琢磨, 寺下 大輔, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi, Okita Yutaka

  日本心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, The Japanese Association of Cardiac Rehabilitation, 京都, Domestic conference

  Oral presentation


• 心臓リハビリテーションにおける管理栄養士の役割と今後の課題

  内田 絢子, 脇田 久美子, 戸田 明代, 坪井 康典, 小川 真人, 小槇 公大, Takahashi Michiko, Usami Makoto, 佐和 琢磨, 寺下 大輔, Kitamura Aki, Kobayashi Seimi

  心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, 京都, Domestic conference

  Oral presentation


• 心臓リハビリテーションにおける管理栄養士の役割と今後の課題

  内田 絢子, 脇田 久美子, 戸田 明代, 坪井 康典, 小川 真人, 小槇 公大, Takahashi Michiko, Usami Makoto, 佐和 琢磨, 寺下 大輔, Kitamura Aki, Kobayashi Seimi

  日本心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, The Japanese Association of Cardiac Rehabilitation, 京都, Domestic conference

  Poster presentation


• 血管平滑筋細胞における高グルコース誘導性のアルカリフォスファターゼ（ALP）遺伝子発現増加およびALP活性亢進へのRho-ROCK経路およびBMPERの関与

  寺尾 侑也, Kobayashi Seimi, Hirata Ken-ichi, Rikitake Yoshiyuki

  The 23rd Annual Scientific Meeting of the Japanese Vascular Biology and Medicine Organization, Dec. 2015, Japanese, The Japanese Vascular Biology and Medicine Organization, 神戸, Domestic conference

  Poster presentation


• Cardio pulmonary Exercise Testing is Valuable for Assessing Exercise Capacity and Hemodynamic Status in Patients with Chronic Thromboembolic Pulmonary Hypertension

  坪井 康典, Kobayashi Seimi, Tanaka Hidekazu, 寺下 大輔, 佐和 琢磨, 新倉 悠人, Nakayama Kazuhiko, 江本 憲昭, Hirata Ken-ichi

  The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, Domestic conference

  Oral presentation


• Safety of Cardiopulmonary Exercise Testing for Assessing Preoperative Exercise Capacity in Japanese Patients with Asymtomatic Aortic Stenosis

  小槇 公大, Kobayashi Seimi, 坪井 康典, 小川 真人, 井澤 和大, 佐和 琢磨, Kitamura Aki, Okita Yutaka, Hirata Ken-ichi

  The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, Domestic conference

  Oral presentation


• Poor exercise capacity is associated with the prevalence of postoperative delirium in elective cardiac surgery.

  小川 真人, 井澤和大, Kitamura Aki, Kobayashi Seimi, 坪井 康典, 小槇 公大, 寺下 大輔, 佐和 琢磨, Hirata Ken-ichi

  The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, 【Background】Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial, but has not been fully explored. The, Domestic conference

  Oral presentation


• 肺高血圧症治療における心臓リハビリテーションと運動耐容能評価―診断時から回復期に渡る長期介入の提言―

  坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 絹谷 洋人, Nakayama Kazuhiko, 井澤 和大, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi

  The 21th Annual Scientific Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2015, Japanese, The Japanese Association of Cardiac Rehabilitation, 福岡, 【背景】当施設では新規肺高血圧症(PH)患者に対し、内科的、外科的治療を行う前の診断時から心臓リハビリテーション(心リハ)を行っている。【方法】2010年6月から2014年12月までに、診断時から心肺運動負荷試験を用い運動耐容能評価を行ったPH患者41例（年齢57±16歳、女性28例、治療前平均肺動脈圧：37.8±12.8mmHg、心係数：2.4±0.8 l/min/m2）を対象に治療前後の運動耐容能の変化を検討した(観察期間：293±261日)。【結果】治療後、運動耐容能は有意に改善したが、依然として低値であった（%予測最高酸素摂取量：46.8±11.8％ vs. 58.6±14.0％ p<0.0001, VE/VCO2 slope 45.1±13.9 vs. 36.6±12.5 p<0.0001）。対象患者のうち、心不全による再入院が5/41例、, Domestic conference

  Public symposium


• 左心補助人工心臓（LVAS）から離脱した症例における運動能力と社会心理的指標の推移

  小川 真人, Kobayashi Seimi, 坪井 康典, 小槇 公大, 井澤 和大, 寺下 大輔, 佐和 琢磨, Tanaka Hidekazu, Sakai Yoshitada, Hirata Ken-ichi

  The 21th Annual Scientific Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2015, Japanese, The Japanese Association of Cardiac Rehabilitation, 福岡, Domestic conference

  Poster presentation


• 2-Aminobutyric acid reflects myocardial redox state in doxorubicin-induced cardiomyopathy

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  11th International Conference of the Metabolomics Society (Metabolomics 2015), Jun. 2015, English, Metaboomics Society, San Francisco, USA, Introduction:Clinical usage of doxorubicin (DOX) as a chemotherapeutic drug is limited by cumulative dose-related cardiotoxicity caused by oxidative stress. Empiric dose limitation is insufficient to prevent DOX-induced cardiotoxicity due to a great varia, International conference

  Poster presentation


• 心臓血管外科手術前の低栄養状態と術後リハビリテーション進行遅延の関係について

  小川 真人, Inoue Takeshi, 坪井 康典, 小槇 公大, 井澤 和大, Kobayashi Seimi, Sakai Yoshitada, Ono Rei, Hirata Ken-ichi, Okita Yutaka

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, Japanese, The Japanese Circulation Society, 大阪, Domestic conference

  Poster presentation


• バルーン肺動脈形成術による慢性血栓塞栓性肺高血圧症患者の最高酸素摂取量改善に関与する術前因子および治療前後変化の検討

  坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 絹谷 洋人, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, Japanese, The Japanese Circulation Society, 大阪, 【背景】 慢性血栓塞栓性肺高血圧症(CTEPH)に対する治療目標として心肺運動負荷試験(CPX)指標の1つである最高酸素摂取量(Peak VO2)が用いられているが、バルーン肺動脈形成術(BPA)によるCTEPH患者のPeak VO2改善に関与する術前因子および治療前後変化に関する検討を認めない。【方法】2011年5月から2014年10月までに当院循環器内科にてBPAおよび治療前後評価としてCPXが施行されたCTEPH患者連続20例(年齢63±12歳、女性14例)を対象とし、後ろ向き解析を行った。BPA前後のPeak VO2改善(Δ Peak VO2)の中央値であった2.4ml/kg/minをカットオフ値とし、Responder群(RG、11例とNon-responder群(NRG、9例)の2群に分類し、術前因子および治療前後変化に関する比較検討を行, Domestic conference

  Poster presentation


• Feasibility of 2-Aminobutyric acid as a biomarker for early detection of doxorubicin-induced cardiotoxicity

  Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi

  The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background:Empiric dose limitation is insufficient to prevent doxorubicin (DOX)-induced cardiotoxicity due to a great variability in individual DOX tolerance. Recently, we revealed that 2-aminobutyric acid (2-AB) was produced as a byproduct of glutathione, Domestic conference

  Oral presentation


• Circulating levels of 2-Aminobutyric acid reflect myocardial redox state in patients with atrial septal defects

  Irino Yasuhiro, Toh Ryuji, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi

  American Heart Association Scientific Sessions 2014, Nov. 2014, English, American Heart Association, シカゴ, アメリカ, Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectromet, International conference

  Poster presentation


• 2-Aminobutyric acid, a potential indicator of oxidative stress in failing hearts

  Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi

  The 18th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2014, Japanese, The Japanese Heart Failure Society, 大阪, Early diagnosis of heart failure (HF) remains difficult and identification of more sensitive biomarkers than conventional ones is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patie, Domestic conference

  Oral presentation


• Exploration of biomarkers for the detection of heart failure

  Irino Yasuhiro, Toh Ryuji, 森 健茂, 長尾 学, 本庄 友行, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, 宮田 興子, Hirata Ken-ichi

  The 39th Annual Meeting of the Japanese Soxiety for Biomedical Mass Spectrometry, Oct. 2014, Japanese, The Japanese Soxiety for Biomedical Mass Spectrometry, 千葉, (Background) Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task.(Methods) We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromat, Domestic conference

  Poster presentation


• Expression and pro-inflammatory functions of FAM5C, a genetic risk factor for acute mayocardial infarction, in vascular endothelial cells

  Mitsuo Kinugasa, Rikitake Yoshiyuki, Kobayashi Seimi, Kinta Hatakeyama, Shota Yamana, Fumie Kureha, Junya Satoh, Yujiro Asada, Hirata Ken-ichi

  78th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2014, English, the Japanese Circulation Society, 東京, Domestic conference

  Poster presentation


• ERK Acts Downstream of Nectin-like Molecule-5 in Phenotypic Reversion of Vascular Smooth Muscle Cells

  Fumie Kureha, Kobayashi Seimi, Mitsuo Kinugasa, Hirata Ken-ichi, Rikitake Yoshiyuki

  第77回日本循環器学会総会, Mar. 2013, English, 日本循環器学会, 横浜, Necl-5 regulates phenotypic reversion of VSMCs via ERK., Domestic conference

  Poster presentation


• Elevation of plasma BMPER levels in patients with coronary artery disease

  Kobayashi Seimi, Ishida Tatsuro, Hirata Ken-ichi, Rikitake Yoshiyuki

  第77回日本循環器学会総会, Mar. 2013, Japanese, 日本循環器学会, 横浜, BMPER levels were elevated in patients with coronary artery disease., Domestic conference

  Oral presentation


• Endothelial lipase in the heart modulates pressure overload-induced heart failure through fatty acid utilization

  Hideto Nakajima, Ishida Tatsuro, Michiko Monguchi, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Toh Ryuji, Kobayashi Seimi, Hirata Ken-ichi

  Scientific Sessions 2012 American Heart Assosiation, Nov. 2012, English, American Heart Assosiation, Los Angeles, We have provided a novel finding that EL may be an alternative candidate to provide FA to the heart and regulate cardiac function. This effect seemed relevant particularly under the inflammatory condition where the action of LPL is downregulated., International conference

  Poster presentation


• マウス内膜肥厚形成におけるネクチン様分子-5の役割

  呉羽 布美恵, Kobayashi Seimi, 衣笠 允雄, Hirata Ken-ichi, Rikitake Yoshiyuki

  第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, Necl-5がマウス頸動脈結紮後の内膜肥厚形成を促進することを示した。, Domestic conference

  Poster presentation


• VEGFによる血管新生におけるNecl-5の役割

  衣笠 允雄, Kobayashi Seimi, 山名 祥太, 銕 祐介, 呉羽 布美恵, Hirata Ken-ichi, Rikitake Yoshiyuki

  第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, Necl-5が血管新生を促進することを示した。, Domestic conference

  Poster presentation


• BMPER（BMP-binding endothelial regulator）による血管平滑筋細胞の骨芽細胞様細胞への形質転換

  Kobayashi Seimi, 衣笠 允雄, 銕 祐介, Hirata Ken-ichi, Rikitake Yoshiyuki

  第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, BMPERが血管平滑筋細胞の骨芽細胞様細胞への形質転換を促進することを示した。, Domestic conference

  Poster presentation


• Nectin-like Molecule-5 in Vascular Smooth Muscle Cells Regulates Intimal Thickening in Mice

  Fumie Kureha, Kobayashi Seimi, Mitsuo Kinugasa, Mitsuo Kinugasa, Hirata Ken-ichi, Rikitake Yoshiyuki

  第75回日本循環器学会総会・学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• Necl-5/PVR/CD155, an Immunoglobulin-like Cell Adhesion Molecule, Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis

  Mitsuo Kinugasa, Mitsuo Kinugasa, Kobayashi Seimi, Shota Yamana, Shota Yamana, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Hirata Ken-ichi, Rikitake Yoshiyuki

  XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, 国際動脈硬化学会, シドニー, オーストラリア, International conference

  Poster presentation


• Cardiac endothelial lipase expression is augmented in the early stage of heart failure

  Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi

  The XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, The Australian Atherosclerosis Society, シドニー, オーストラリア, International conference

  Poster presentation


• Cardiac Endothelial Lipase Expression is Augmented in a Murine Model of Heart Failure

  Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi

  日本循環器学会学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• Regulation of intimal thickeningfollowing carotid artery ligation in mice by the immunoglobulin-like cell adhesion molecule Necl-5

  Yoshiki Kubo, 久保 嘉輝, 呉羽 布美恵, Fumie Kureha, Seimi Kobayash, Kobayashi Seimi, 衣笠 允雄, Mitsuo Kinugasa, Miyata Muneaki, Miyata Muneaki, 三好 淳, Jun Miyoshi, Hirata Ken-ichi, Hirata Ken-ichi, Takai Yoshimi, Takai Yoshimi, Rikitake Yoshiyuki, Rikitake Yoshiyuki

  第34回日本分子生物学会年会, Dec. 2011, English, 日本分子生物学会, 横浜, Domestic conference

  Poster presentation


• Necl-5, an Immunoglobulin-like Cell Adhesion Molecule, Regulates VEGF-induced Angiogenesis in Ischemia

  Mitsuo Kinugasa, Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Hideto Tawa, Hideto Tawa, Kobayashi Seimi, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Poster presentation


• Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• The Immunoglobulin-like Molecule Necl-5/PVR Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis

  Mitsuo Kinugasa, Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Kobayashi Seimi, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• Increased expression of endothelial lipase in a murine model of heart failure

  中島英人, Ishida Tatsuro, 近藤健介, 森健太, 佐々木真希, 破磯川実, 原口英子, 安田知行, 篠原正和, Kobayashi Seimi, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• BMPER Induced Osteogenic Differentiation in Human Coronary Artery Smooth Muscle Cells via NFkB Activation

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi

  第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference

  Poster presentation


• Necl-5, an Immunoglobulin-like Cell Adhesion Molecule, Regulates VEGF-induced Angiogenesis in Ischemia

  Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Fumie Kureha, Hideto Tawa, Kobayashi Seimi, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Poster presentation


• Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells

  Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Hirata Ken-ichi

  第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference

  Oral presentation


• Regulation of Angiogenesis by An Immunoglobulin-like Molecule Necl-5

  Miyata Muneaki, Rikitake Yoshiyuki, 天野 恭志, 衣笠 允雄, Kobayashi Seimi, 永松 裕一, 武田 匡史, 三好 淳, Hirata Ken-ichi, Takai Yoshimi

  ＢＭＢ2010 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会, Dec. 2010, Japanese, 日本分子生物学会, 日本生化学会, 神戸, Domestic conference

  Poster presentation


• VEGFによる血管新生におけるNecl-5の役割

  衣笠 允雄, Rikitake Yoshiyuki, Kobayashi Seimi, 銕 祐介, Hirata Ken-ichi

  第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference

  Poster presentation


• Regulation of Angiogenesis by the Immunoglobulin-like Molecule Necl-5

  Miyata Muneaki, Rikitake Yoshiyuki, Hisayuki Amano, Mitsuo Kinugasa, Kobayashi Seimi, Yuichi Nagamatsu, Masafumi Takeda, Jun Miyoshi, Hirata Ken-ichi, Takai Yoshimi

  第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会, Dec. 2010, Japanese, 日本分子生物学会/日本生化学会, 神戸, Domestic conference

  Poster presentation


• FGD5によるVEGF誘導性催血管新生能の制御

  銕 佑介, Rikitake Yoshiyuki, Kobayashi Seimi, 衣笠 允雄, Hirata Ken-ichi

  第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference

  Oral presentation


• BMP-binding endothelial regulator (BMPER)は培養ヒト冠動脈平滑筋細胞の骨芽細胞様分化転換を促進する

  Kobayashi Seimi, Rikitake Yoshiyuki, 衣笠 允雄, Hirata Ken-ichi

  第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference

  Oral presentation


• The WHHLMI Rabbit as a Model Animal for Coronary Spastic Angina.

  小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 一也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi

  4th Congress of Asian Federation of Laboratory Animal Science, Nov. 2010, English, Asian Federation of Laboratory Animal Science, Taipei, Taipei International Congress Center (Taiwan), International conference

  Poster presentation


• 不安定狭心症のモデル動物としてのWHHLMIウサギの有用性。

  小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 和也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi

  第4回ウサギフォーラム, Jul. 2010, Japanese, ウサギフォーラム, 秋田, 秋田大学 (日本), Domestic conference

  Oral presentation


• Role of Immunoglobulin-like Cell Adhesion Molecule Necl-5 in Vascular Endothelial Growth Factor-Induced Angiogenesis

  Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi

  第74回日本循環器学会総会, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference

  Poster presentation


• BMP binding endothelial regulator (BMPER) is a novel regulator of human coronary artery calcification

  Kobayashi Seimi, Rikitake Yoshiyuki, Ishida Tatsuro, Emoto Noriaki, Hirata Kenichi

  第74回日本循環器学会総会, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference

  Oral presentation


• Immunoglobulin-like Cell Adhesion Molecule Necl-5 Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis by Controlling the Interaction between VEGFR2 and Integrin αvβ3

  Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi

  Scientific Sessions 2009, Nov. 2009, English, 米国心臓協会, オーランド, アメリカ, International conference

  Poster presentation


• Role of Immunoglobulin-like Cell Adhesion Molecule Necl-5 in VEGF-induced Angiogenesis

  Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi

  XV International Symposium on Atherosclerosis 2009, Jun. 2009, English, Boston Atherosclerosis Society, ボストン, アメリカ, International conference

  Oral presentation


• Role of immunoglobulin-like cell adhesion molecule Necl-5 in VEGF-induced angiogenesis

  Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi

  XV International Symposium on Atherosclerosis, Jun. 2009, English, 国際動脈硬化学会, ボストン, アメリカ, International conference

  Poster presentation


• Plasma tetrahydrobiopterin / dihydrobiopterin : A possible marker of endothelial dysfunction

  Yamashita Tomoya, Shinohara Masakazu, Sasaki Naoto, Kobayashi Seimi, Toh Ryuji, Hirata Kenichi, Kawashima Seinosuke

  第8回NO学会, May 2009, Japanese, 日本NO学会, 仙台, Domestic conference

  Poster presentation


• Requirement of Small G Protein Rap1 and Rap1-binding Protein Afadin in Endothelial Cells for the Regulation of Angiogenesis

  Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi

  第７３回日本循環学会総会, Mar. 2009, Japanese, 日本循環器学会, 大阪, Domestic conference

  Oral presentation


• Plasma pteridine level as a biomarker of cardiovascular diseases

  Shinohara Masakazu, Yamashita Tomoya, Sasaki Naoto, Toh Ryuji, Kobayashi Seimi, Kawashima Seinosuke, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• Oral Anti-CD3 Antibody Treatment Induces CD4+LAP+ Regulatory T Cells and Ameliorates the Development of Atherosclerosis in Mice

  Sasaki Naoto, Yamashita Tomoya, Shinohara Masakazu, Toh Ryuji, Kobayashi Seimi, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Poster presentation


• Inhibition of myocardin deteriorates cardiac function under beta-adrenergic stimulation

  Kobayashi Seimi, Toh Ryuji, Hirata Kenichi

  第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference

  Oral presentation


• Oral Anti-CD3 Antibody Treatment Induces CD4+LAP+ Regulatory T Cells and Ameliorates the Development of Atherosclerosis in Mice

  Sasaki Naoto, Yamashita Tomoya, Shinohara Masakazu, Toh Ryuji, Kobayashi Seimi, Hirata Kenichi

  第７9回AmericanHeartAssociationScientificSession, Nov. 2007, English, The American Heart Association, Orland, アメリカ, International conference

  Oral presentation


• Myocardin is required to prevent mitochondrial damage and cardiac dysfunction in response to beta-adrenergic receptor stimulation

  Kobayashi Seimi, Toh Ryuji, Hirata Kenichi

  第７9回AmericanHeartAssociationScientificSession, Nov. 2007, English, The American Heart Association, Orland, アメリカ, International conference

  Oral presentation

• The regulatory mechanisms of inflammation by exercise via lipid mediators

  Kobayashi Seimi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019, Principal investigator

  Anti-inflammatory action is expected as one of the effects of exercise therapy on cardiovascular diseases, but the mechanisms are unclear. We aimed to examine the mechanisms of anti-inflammatory roles of exercise therapy associated with lipid mediators. The 20-min exercise using cycle ergometer with the intensity around anaerobic threshold (AT) revealed to reduce the ratio of pro-inflammatory lipid mediators (PG group) /anti-inflammatory lipid mediators (Resolvin group) in the plasma of healthy adult volunteer. The vigorous exercise with the intensity of over 140%AT increased the ratio conversely. The results coincide with the idea that the exercise with the intensity of AT is safe and effective for the patients with cardiovascular diseases, and should be encouraged to continue.

  Competitive research funding


• 心臓における細胞間接着分子nectin-2の機能解析

  小林 成美

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 2006 - 2007

  本研究では、初めて細胞間接着分子nectin-2が心筋細胞の介在板に存在し、心不全発症機序に関与していることを示した。 nectin-2 KOマウスの心臓は正常発育し、生理的条件下では正常心機能を呈する。しかし、大動脈縮窄による左室圧負荷モデルにおいて、心肥大の程度に差はなかったが、nectin-2 KOマウスでは野生型に比し著明な心収縮能の低下、肺うっ血(うっ血性心不全)、また、心筋内のびまん性線維化、心筋細胞のアポトーシスの増加などの異常が認められた。電子顕微鏡を用いた検討において、圧負荷下のnectin-2 KOマウスの心臓では、早期から介在板構造の異常(介在板の組み手構造が深くなり、mpofibrilの配列が乱れ間隙が生じる)が認められ、それはヒトの拡張型心筋症の組織に類似していた。 同モデルの心臓組織を用いたウエスタンブロッティングで、Akt、MAPK(p38MAPK、JNK、ERK)など、心不全、心肥大において重要な細胞内シグナル伝達系を検討したところ、MAPKのリン酸化はnectin-2 KOマウスにおいて術後に有意に増加しており、心臓におけるストレス増大を反映していると考えた。他の細胞間接着分子の発現は、N-cadherin、β-catenin、α-catenin、integrinβ1、desmogleinなど、adherens junctionとdesmosomeに関連する分子は手術前後で不変であった。gap junctionに存在するconnexin43はnectin-2 KOマウスの術後で減少傾向にあり、心不全期における同分子の発現に関する従来の報告と合致した。 本研究により、nectin-2が心肥大から心不全への移行に重要な分子であることが示唆された。