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SATOMI-KOBAYASHI Seimi
Graduate School of Medicine / Faculty of Medical Sciences
Professor

Researcher basic information

■ Research Areas
  • Life sciences / Cardiology

Research activity information

■ Award
  • Mar. 2013 日本循環器学会, 女性研究者奨励賞, Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER). Satomi-Kobayashi S, et al. J Biol Chem. 2012 Aug 31;287(36):30336-45.
    Kobayashi Seimi
    Japan society

■ Paper
  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Kodai Komaki, Takumi Hirabayashi, Kumiko Wakida, Saori Saitoh, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Michiko Takahashi, Ken-ichi Hirata
    Corresponding, Elsevier BV, Sep. 2025, Journal of Cardiology
    [Refereed]
    Scientific journal

  • Naoya Kuwahara, Manabu Nagao, Masakazu Shinohara, Kenta Kaneshiro, Takuo Emoto, Takeshi Yoshida, Terunobu Fukuda, Makoto Nishimori, Seimi Satomi-Kobayashi, Hiromasa Otake, Ken-Ichi Hirata, Tatsuro Ishida, Ryuji Toh
    BACKGROUND: ATP citrate lyase (ACLY) is a key enzyme in de novo lipogenesis that generates acetyl-CoA from citrate. Although fatty acids are required for energy production and biomass synthesis in the heart, the regulatory mechanisms of ACLY-mediated de novo lipogenesis in pathological cardiac fibroblasts remain unknown. The aim of this study was to investigate the biological role of ACLY in cardiac remodeling. METHODS: Adeno-associated virus serotype 9-mediated shRNA targeting Acly was intravenously injected into C57BL/6J male mice. The mice were subsequently continuously infused with a mixture of angiotensin II and phenylephrine. Cardiac phenotypes were evaluated via histological staining. Cell proliferation assays, stable isotope tracing with 13C-labeled glucose, and chromatin immunoprecipitation assays were performed using human cardiac fibroblasts. RESULTS: ACLY expression was upregulated in the heart sections of mice treated with angiotensin II/phenylephrine, in particular in fibrotic areas. Masson trichrome staining revealed that Acly gene silencing significantly reduced cardiac fibrosis in these mice. Both siRNA-mediated ACLY knockdown and pharmacological ACLY inhibition suppressed the proliferation and expression of fibrous proteins in cultured human cardiac fibroblasts stimulated with transforming growth factor-β. Mechanistically, ACLY inhibition reduced de novo lipogenesis, limiting the fatty acid supply essential for cellular growth and proliferation. It also decreased H3K9 and H3K27 acetylation, in addition to the presence of acetylated H3K9 and H3K27 at the promoter regions of fibrotic genes. CONCLUSIONS: Our findings demonstrate that ACLY plays an important role in maladaptive cardiac fibrosis. ACLY could be a novel therapeutic target to prevent the development of heart failure.
    Jun. 2025, Hypertension (Dallas, Tex. : 1979), 82(6) (6), 1116 - 1128, English, International magazine
    [Refereed]
    Scientific journal

  • Junko Asakura, Manabu Nagao, Masakazu Shinohara, Tetsuya Hosooka, Naoya Kuwahara, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Hiromasa Otake, Tatsuro Ishida, Wataru Ogawa, Ken-Ichi Hirata, Ryuji Toh
    BACKGROUND: Systemic insulin resistance plays an important role in the pathogenesis of type 2 diabetes and its complications. Although impaired branched-chain amino acid (BCAA) metabolism has been reported to be involved in the development of diabetes, the relationship between cardiac BCAA metabolism and the pathogenesis of diabetic cardiomyopathy (DbCM) remains unclear. OBJECTIVES: The aim of this study was to investigate BCAA metabolism in insulin-resistant hearts by using a novel mouse model of DbCM. METHODS: The cardiac phenotypes of adipocyte-specific 3'-phosphoinositide-dependent kinase 1 (PDK1)-deficient (A-PDK1KO) mice were assessed by histological analysis and echocardiography. The metabolic characteristics and cardiac gene expression were determined by mass spectrometry or RNA sequencing, respectively. Cardiac protein expression was evaluated by Western blot analysis. RESULTS: A-PDK1KO mouse hearts exhibited hypertrophy with prominent insulin resistance, consistent with cardiac phenotypes and metabolic disturbances previously reported as DbCM characteristics. RNA sequencing revealed the activation of BCAA uptake in diabetic hearts. In addition, the key enzymes involved in cardiac BCAA catabolism were downregulated at the protein level in A-PDK1KO mice, leading to the accumulation of BCAAs in the heart. Mechanistically, the accumulation of the BCAA leucine caused cardiac hypertrophy via the activation of mammalian target of rapamycin complex 1 (mTORC1). CONCLUSIONS: A-PDK1KO mice closely mimic the cardiac phenotypes and metabolic alterations observed in human DbCM and exhibit impaired BCAA metabolism in the heart. This model may contribute to a better understanding of DbCM pathophysiology and to the development of novel therapies for this disease.
    Apr. 2025, Cardiovascular diabetology, 24(1) (1), 167 - 167, English, International magazine
    [Refereed]
    Scientific journal

  • Masato Ogawa, Masatsugu Okamura, Takuma Yagi, Kenichiro Maekawa, Kota Amakasu, Tatsuro Inoue, Seimi Satomi-Kobayashi, Megumi Katayama, Yumi Muraki, Masaya Akashi
    Oral frailty, which encompasses decline in oral health and function with aging, has broader health implications. However, its specific role in individuals with cardiovascular disease (CVD) remains poorly understood. In this scoping review we investigated the prevalence, assessment tools, and potential intervention strategies for oral frailty in patients with CVD. We used the Population, Concept, and Context framework as follows: Population: Patients with CVD; Concept: Existing literature on oral frailty in the context of CVD; Context: Not restricted. Extracted data were synthesized qualitatively. From an initial pool of 3,199 studies, 70 were included in the final analysis, with a cumulative sample size of 891,450 individuals. Among the assessment tools for oral frailty, the number of teeth was the most commonly used measure in 39 studies, followed by the Decayed, Missing, Filled Index. Of the studies, 5 studies indicated that coronary artery disease and diabetes are risk factors for oral frailty, and 8 identified poor oral health as a predictor of cardiac events. However, no study clearly defined oral frailty in the context of CVD. Additionally, only 2 studies explored the relationship between oral health and physical frailty. This results of this review underscore the lack of a standardized definition for oral frailty in CVD. Although associations between oral health and prognosis were observed, further research is needed to clarify the definitions and explore causal relationships.
    Apr. 2025, Circulation reports, 7(4) (4), 223 - 230, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Kodai Komaki, Takumi Hirabayashi, Kumiko Wakida, Saori Saitoh, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Michiko Takahashi, Kenji Okada, Ken-ichi Hirata
    Corresponding, Elsevier BV, Dec. 2024, Clinical Nutrition
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hidekazu Tanaka, Tatsuro Ishida, Takuo Emoto, Manabu Nagao, Yu Izawa, Terunobu Fukuda, Takayoshi Toba, Eriko Hisamatsu, Yu Taniguchi, Kimitake Imamura, Mitsuru Takami, Hiroyuki Kawamori, Hiromasa Otake, Koji Fukuzawa, Ryuji Toh, Seimi Satomi-Kobayashi, Tomoya Yamashita, Ken-ichi Hirata
    Sep. 2024, CIRCULATION JOURNAL, 88(9) (9), 1502 - 1508, English
    [Invited]
    Scientific journal

  • Masato Ogawa, Seimi Satomi-Kobayashi, Mari Hamaguchi, Kodai Komaki, Hifumi Kusu, Kazuhiro P. Izawa, Shunsuke Miyahara, Yoshitada Sakai, Ken-ichi Hirata, Kenji Okada
    Corresponding, Elsevier BV, Feb. 2024, JTCVS Open
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Junko Asakura, Manabu Nagao, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Takuya Iino, Yutaro Seto, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh
    Elevated circulating homocysteine (Hcy) is a well-known risk factor for cardiovascular diseases (CVDs), including coronary artery disease (CAD) and heart failure (HF). It remains unclear how Hcy and its derivatives relate to left ventricular (LV) diastolic function. The aim of the present study was to investigate the relationship between plasma Hcy-related metabolites and diastolic dysfunction (DD) in patients with heart disease (HD). A total of 62 HD patients with preserved LV ejection fraction (LVEF ≥ 50%) were enrolled. Plasma Hcy and its derivatives were measured by liquid chromatography‒mass spectrometry (LC-MS/MS). Spearman's correlation test and multiple linear regression models were used to analyze the associations between metabolite levels and LV diastolic function. The cystine/methionine (CySS/Met) ratio was positively correlated with LV diastolic function, which was defined from the ratio of mitral inflow E and mitral e' annular velocities (E/e') (Spearman's r = 0.43, p < 0.001). When the subjects were categorized into two groups by E/e', the high-E/e' group had a significantly higher CySS/Met ratio than the low-E/e' group (p = 0.002). Multiple linear regression models revealed that the CySS/Met ratio was independently associated with E/e' after adjustment for age, sex, body mass index (BMI), diabetes mellitus, hypertension, chronic kidney disease (CKD), hemoglobin, and lipid peroxide (LPO) {standardized β (95% CI); 0.14 (0.04-0.23); p = 0.005}. Hcy, CySS, and Met did not show a significant association with E/e' in the same models. A high plasma CySS/Met ratio reflected DD in patients with HD.
    Aug. 2023, Heart and vessels, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Tomoyo Hamana, Hiroyuki Kawamori, Seimi Satomi-Kobayashi, Yuzuru Yamamoto, Yoshihiko Ikeda, Ken-Ichi Hirata
    BACKGROUND: Although cardiac involvement is relatively common in mixed connective tissue disease (MCTD), few reports on MCTD-associated fulminant myocarditis are available. CASE SUMMARY: A 22-year-old woman diagnosed with MCTD was admitted to our institution for cold-like symptoms and chest pain. Echocardiography revealed that the left ventricular ejection fraction (LVEF) had rapidly decreased from 50 to 20%. Because endomyocardial biopsy revealed no significant lymphocytic infiltration, immunosuppressant drugs were not started initially; however, steroid pulse therapy (methylprednisolone, one1000 mg/day) was initiated due to prolonged symptoms and unimproved haemodynamics. Despite strong immunosuppressant therapy, the LVEF did not improve, and severe mitral regurgitation appeared. Three days after steroid pulse therapy initiation, she experienced a sudden cardiac arrest; thus, venoarterial extracorporeal membrane oxygenation (VA-ECMO) and intra-aortic balloon pumping (IABP) were initiated. Subsequent immunosuppressant therapy was continued with prednisolone (100 mg/day) and intravenous cyclophosphamide (1000 mg). Six days after steroid therapy initiation, the LVEF improved to 40% and then recovered to near-normal levels. After successful weaning off of VA-ECMO and IABP, she was discharged. Thereafter, a detailed histopathological examination revealed multi-focal signs of ischaemic micro-circulatory injury and diffuse HLA-DR in the vascular endothelium, suggesting an autoimmune inflammatory response. DISCUSSION: We report a rare case of fulminant myocarditis in a patient with MCTD who recovered with immunosuppressive treatment. Despite the absence of significant lymphocytic infiltration findings on histopathological examination, patients with MCTD may experience a dramatic clinical course. Although it is unclear whether myocarditis is triggered by viral infections, certain autoimmune mechanisms may lead to its development.
    Apr. 2023, European heart journal. Case reports, 7(4) (4), ytad174, English, International magazine
    [Refereed]

  • 井澤 和大, 小林 成美, 小川 真人, 平野 康之, 酒井 良忠
    (NPO)日本心臓リハビリテーション学会, Mar. 2023, 心臓リハビリテーション, 29(1) (1), 18 - 22, Japanese
    [Invited]

  • Masato Ogawa, Seimi Satomi-Kobayashi, Mari Hamaguchi, Kodai Komaki, Kazuhiro P Izawa, Shunsuke Miyahara, Takeshi Inoue, Yoshitada Sakai, Ken-ichi Hirata, Kenji Okada
    Abstract Aims Post-extubation dysphagia (PED), an often overlooked problem, is a common and serious complication associated with mortality and major morbidity after cardiovascular surgery. Dysphagia is considered an age-related disease, and evaluating its long-term effects is a pressing issue with rapidly progressing ageing worldwide. Therefore, we examined the effect of PED on functional status and long-term cardiovascular events in patients undergoing cardiovascular surgery. Methods and results This single-centre, retrospective cohort study included 712 patients who underwent elective cardiovascular surgery and met the inclusion criteria. Patients were divided into PED and non-PED groups based on their post-operative swallowing status. The swallowing status was assessed using the Food Intake Level Scale. Functional status was evaluated as hospital-associated disability (HAD), defined as a decrease in activities of daily living after hospital discharge compared with preoperative values. The patients were subsequently followed up to detect major adverse cardiac and cerebrovascular events (MACCEs). Post-extubation dysphagia was present in 23% of the 712 patients and was independently associated with HAD (adjusted odds ratio, 2.70). Over a 3.5-year median follow-up period, MACCE occurred in 14.1% of patients. Multivariate Cox proportional hazard analysis revealed HAD to be independently associated with an increased risk of MACCE (adjusted hazard ratio, 1.85), although PED was not significantly associated with MACCE. Conclusion Post-extubation dysphagia was an independent HAD predictor, with the odds of HAD occurrence being increased by 2.7-fold due to PED. Hospital-associated disability accompanied by PED is a powerful predictor of poor prognosis. Perioperative evaluation and management of the swallowing status, and appropriate therapeutic interventions, are warranted.
    Corresponding, Oxford University Press (OUP), Sep. 2022, European Journal of Cardiovascular Nursing, 22(6) (6), 602 - 609
    [Refereed]
    Scientific journal

  • Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Yasuhiro Irino, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata
    Alterations in cardiac metabolism are strongly associated with the pathogenesis of heart failure (HF). We recently reported that glutamine-dependent anaplerosis, termed glutaminolysis, was activated by H2O2 stimulation in rat cardiomyocytes, which seemed to be an adaptive response by which cardiomyocytes survive acute stress. However, the molecular mechanisms and fundamental roles of glutaminolysis in the pathophysiology of the failing heart are still unknown. Here, we treated wild-type mice (C57BL/6J) and rat neonatal cardiomyocytes (RNCMs) and fibroblasts (RNCFs) with angiotensin II (ANG II) to induce pathological cardiac remodeling. Glutaminase 1 (GLS1), a rate-limiting glutaminolysis enzyme, was significantly increased in ANG II-induced mouse hearts, RNCMs and RNCFs. Unexpectedly, a GLS1 inhibitor attenuated ANG II-induced left ventricular hypertrophy and fibrosis in the mice, and gene knockdown and pharmacological perturbation of GLS1 suppressed hypertrophy and the proliferation of RNCMs and RNCFs, respectively. Using mass spectrometry (MS)-based stable isotope tracing with 13C-labeled glutamine, we observed glutamine metabolic flux in ANG II-treated RNCMs and RNCFs. The incorporation of 13C atoms into tricarboxylic acid (TCA) cycle intermediates and their derivatives was markedly enhanced in both cell types, indicating the activation of glutaminolysis in hypertrophied hearts. Notably, GLS1 inhibition reduced the production of glutamine-derived aspartate and citrate, which are required for the biosynthesis of nucleic acids and lipids, possibly contributing to the suppression of cardiac hypertrophy and fibrosis. The findings of the present study reveal that GLS1-mediated upregulation of glutaminolysis leads to maladaptive cardiac remodeling. Inhibition of this anaplerotic pathway could be a novel therapeutic approach for HF.NEW & NOTEWORTHY To our knowledge, this study is the first to demonstrate that increased GLS1 expression and subsequent activation of glutaminolysis are associated with exacerbation of cardiac hypertrophy and fibrosis. Inhibiting GLS1 antagonized the adverse cardiac remodeling in vitro and in vivo, partly due to reduction of glutamine-derived metabolites, which are necessary for cellular growth and proliferation. Increased glutamine utilization for anabolic reactions in cardiac cells may be related to the pathogenesis and development of HF.
    May 2022, American journal of physiology. Heart and circulatory physiology, 322(5) (5), H749-H761, English, International magazine
    [Refereed]
    Scientific journal

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Kodai Komaki, Kazuhiro P Izawa, Mari Hamaguchi, Takeshi Inoue, Yoshitada Sakai, Ken-Ichi Hirata, Kenji Okada
    BACKGROUND: Postextubation dysphagia (PED) is a serious postoperative complication following cardiovascular surgery that can lead to a worse prognosis. On the other hand, frailty is a prognostic factor in patients who undergo cardiac surgery. OBJECTIVES: This study investigated the effect of frailty status on PED and impact of PED on postoperative complications. METHODS: This single-center retrospective cohort study included 644 consecutive patients who underwent elective cardiovascular surgery between May 1, 2014, and December 31, 2020; they were assigned to the PED or non-PED group based on postoperative swallowing status, and postoperative complications were investigated. Frailty status and physical functions, including walking speed, grip strength, Short Physical Performance Battery, and 6-minute walking distance, were preoperatively assessed; the frailty-status cutoff for predicting PED was determined from the receiver-operating characteristic curve. RESULTS: In this study cohort (mean age 67.7 years), the overall PED prevalence was 14.8%; preoperative frailty had a significantly higher prevalence in the PED group (50.0%) than in the non-PED group (20.3%; P < 0.001). PED correlated with a higher incidence of postoperative pneumonia and prolonged intensive care unit or hospital stay (P < 0.05 for all). After adjustment for confounders, multiple regression analysis revealed that preoperative frailty was independently associated with PED (P < 0.001). CONCLUSIONS: PED occurred commonly after cardiovascular surgery and increased the risk of postoperative complications. Preoperative frailty was independently associated with PED. The 6-minute walking distance was the most powerful predictor of PED. Evaluation of preoperative frailty status is important for risk stratification and prevention of postoperative morbidity in patients undergoing surgery.
    Corresponding, Feb. 2022, JACC. Asia, 2(1) (1), 104 - 113, English, International magazine
    [Refereed]
    Scientific journal

  • Todo Saki, Matsumoto Kensuke, Fujita Hiroshi, Miwa Keisuke, Izawa Yu, Kobayashi Seimi, Hirata Ken-ichi
    症例は76歳，女性．計3度の胸椎圧迫骨折ののち，徐々に座位時の呼吸困難感を訴えるようになった．このため，次第に日常生活活動度も低下するようになり，呼吸困難の原因精査のため当院入院となった．経胸壁心エコー図検査を施行したところ，仰臥位では明らかな短絡は認められなかったものの，座位時には超音波コントラスト剤による左心系の染影が確認された．卵円孔開存を基礎としたplatypnea-orthodeoxia syndromeが強く疑われたため，引き続き経食道心エコー図検査を施行．座位への体位変換により大きく開大する卵円孔開存の存在が確認され，同部を介した多量のコントラスト剤の左房流入を確認することができた．経皮的卵円孔閉鎖術を実施したところ，術後は呼吸困難および低酸素血症は消失した．本症例は，卵円孔開存の存在に加えて胸椎圧迫骨折を繰り返したことで亀背が進行し，その結果蛇行した大動脈が心房中隔を変形させ，右左短絡が形成されplatypnea-orthodeoxia syndromeを呈するに至ったものと考えられた．
    Japan Heart Foundation, Oct. 2021, Shinzo, 53(10) (10), 1118 - 1123, Japanese
    [Refereed]

  • 井澤 和大, 小林 成美, 笠原 酉介, 平野 康之
    (株)全日本病院出版会, Jun. 2021, MEDICAL REHABILITATION, (262) (262), 7 - 12, Japanese
    [Invited]

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada
    Corresponding, Mar. 2021, CJC Open, 3(3) (3), 276 - 284
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Kenji Okada, Ken-Ichi Hirata
    Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.
    Corresponding, Feb. 2021, Heart and vessels, 36(8) (8), 1234 - 1245, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Koichi Watanabe, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Takuya Iino, Sachiko Yoshikawa, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata
    BACKGROUND: Metabolic remodeling in cardiomyocytes is deeply associated with the pathogenesis of heart failure (HF). Glutaminolysis is an anaplerotic pathway that incorporates α-ketoglutarate (αKG) derived from glutamine into the tricarboxylic acid (TCA) cycle. It is well known that cancer cells depend on glutamine for their increased energy demand and proliferation; however, the physiological roles of glutamine metabolism in failing hearts remain unclear. OBJECTIVE: To investigate the regulatory mechanisms and biological effects of glutamine metabolism in oxidative stress-induced failing myocardium. METHODS AND RESULTS: The intracellular levels of glutamine, glutamate, and αKG were significantly decreased by H2O2 stimulation in rat neonatal cardiomyocytes (RNCMs). To better understand the metabolic flux in failing myocardium, we performed a stable isotope tracing study and found that glutaminolysis was upregulated in RNCMs under oxidative stress. Consistent with this, the enzymatic activity of glutaminase (Gls), which converts glutamine to glutamate, was augmented in RNCMs treated with H2O2. These findings suggest that glutamine anaplerosis is enhanced in cardiomyocytes under oxidative stress to compensate for the reduction of αKG. Furthermore, the inhibition of Gls reduced cardiac cell viability, ATP production, and glutathione (GSH) synthesis in RNCMs with H2O2 stimulation. Finally, we evaluated the effects of αKG on failing myocardium and observed that dimethyl α-ketoglutarate (DMKG) suppressed oxidative stress-induced cell death likely due to the enhancement of intracellular ATP and GSH levels. CONCLUSION: Our study demonstrates that under oxidative stress, glutaminolysis is upregulated to compensate for the loss of αKG and its replenishment into the TCA cycle, thereby exerting cardioprotective effects by maintaining ATP and GSH levels. Modulation of glutamine metabolism in failing hearts might provide a new therapeutic strategy for HF.
    Jan. 2021, Biochemical and biophysical research communications, 534, 687 - 693, English, International magazine
    [Refereed]
    Scientific journal

  • 包括的心臓リハビリテーション 光と影
    井澤 和大, 小林 成美, 小川 真人, 平野 康之, 酒井 良忠
    (公社)日本リハビリテーション医学会, Nov. 2020, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S286 - S286, Japanese
    [Invited]

  • Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation.
    Eriko Hisamatsu, Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takuya Iino, Tetsuya Hara, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata
    A large amount of evidence suggests that high-density lipoprotein (HDL) has anti-atherosclerotic properties. HDL-cholesterol (HDL-C) has also been widely used as a marker of cardiovascular disease. Recently, it was reported that plasma HDL-C levels are inversely correlated with cancer risk. However, the relationship between HDL and cancer pathophysiology remains unknown. Here, we sought to investigate the effect of HDL on cancer progression. First, we focused on fibronectin-an essential extracellular matrix glycoprotein-as an HDL-associated protein and found that only 7.4% of subjects in this study had fibronectin in HDL isolated from their plasma. The fibronectin-containing HDL (FN-HDL) increased the phosphorylation of focal adhesion kinase (FAK) in HeLa cells compared to HDL without fibronectin, further inducing the phosphorylation in a dose-dependent manner. Second, we found that fibronectin-treated HDL activated the phosphorylation of FAK, and its upstream effector blocked the phosphorylation induced by FN-HDL. Finally, we demonstrated that FN-HDL promoted cancer cell proliferation and adhesion compared to HDL without fibronectin. Our study showed the possible mechanism by which FN-HDL enhanced cancer cell proliferation and adhesion via the FAK signaling pathway. Further investigation of the roles of HDL components in tumorigenesis might provide novel insight into cancer pathophysiology.
    Aug. 2020, The Kobe journal of medical sciences, 66(1) (1), E40-E48, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Yoshitada Sakai, Masaya Akashi, Ken-ichi Hirata
    Elsevier BV, Aug. 2020, Journal of Cardiology
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Yasuhiro Irino, Seimi Satomi-Kobayashi, Masakazu Shinohara, Ryuji Toh, Farouc A Jaffer, Tatsuro Ishida, Ken-Ichi Hirata
    This work established a new murine venous thromboembolism (VTE) model. This model has multiple novel features representing clinical VTE that include the following: 1) deep venous thrombosis (DVT) was formed and extended in the long axis of femoral/saphenous vein; 2) thrombus was formed in a venous valve pocket; 3) deligation of suture-induced spontaneous pulmonary emboli of fibrin-rich DVT; and 4) cardiac motion-free femoral/saphenous vein allowed high-resolution intravital microscopic imaging of fibrin-rich DVT. This new model requires only commercially available epifluorescence microscopy. Therefore, this model has significant potential for better understanding of VTE pathophysiology.
    Apr. 2020, JACC. Basic to translational science, 5(4) (4), 344 - 356, English, International magazine
    [Refereed]

  • 小川真人, 井澤和大, 小林成美, 後竹康子, 坪井康典, 小槇公大, 桶本翔吾, 吉田尚史, 丸山孝樹, 酒井良忠, 平田健一
    サルコペニアを有する心不全患者の身体活動量と健康関連QOLの特性について検討した。心不全検査目的に当院に入院した65歳以上の高齢者234名を対象とした。サルコペニアは59例(25.2%)に認められ、サルコペニア群は非サルコペニア群と比し、有意に高齢でBrain Natriuretic Peptide値が高く、BMI、アルブミン値、ヘモグロビン値は低値であった。交絡因子を調整後もInternational Physical Activity Questionnaireはサルコペニア群で有意に低値であった。健康関連QOLの比較では、身体的サマリースコアはサルコペニア群で有意に低値を示し、精神的サマリースコアもサルコペニア群で有意に低値を示したが、役割・社会的サマリースコアには両群間で有意な差はみられなかった。高齢心不全患者において、サルコペニアは高率で発生し、サルコペニア患者は身体活動量が有意に低下していた。
    国立大学リハビリテーション療法士協議会, 2020, 国立大学リハビリテーション療法士学術大会誌, in press, 30 - 35, Japanese
    [Refereed]

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Kumiko Wakida, Yasuko Gotake, Kazuhiro P Izawa, Yoshitada Sakai, Kenji Okada
    OBJECTIVES: The provision of inpatient programs that reduce the incidence of readmission after cardiac surgery remains challenging. Investigators have focused on multidisciplinary cardiac rehabilitation (CR) because it reduces the postoperative readmission rate; however, most previous studies used outpatient models (phase II CR). We retrospectively investigated the effect of comprehensive multidisciplinary interventions in the acute inpatient phase (phase I CR) on unplanned hospital readmission. METHODS: In a retrospective cohort study, we compared consecutive patients after cardiac surgery. We divided them into the multidisciplinary CR (multi-CR) group or conventional exercise-based CR (conv-CR) group according to their postoperative intervention during phase I CR. Multi-CR included psychological and educational intervention and individualized counseling in addition to conv-CR. The primary outcome was unplanned readmission rates between the groups. A propensity score-matching analysis was performed to minimize selection biases and the differences in clinical characteristics. RESULTS: In our cohort (n = 341), 56 (18.3%) patients had unplanned readmission during the follow-up period (median, 419 days). Compared with the conv-CR group, the multi-CR group had a significantly lower unplanned readmission rate (multivariable regression analysis; hazard ratio, 0.520; 95% confidence interval, 0.28-0.95; P = .024). A Kaplan-Meier analysis of our propensity score-matched cohort showed that, compared with the conv-CR group, the multi-CR group had a significantly lower incidence of readmission (stratified log-rank test, P = .041). CONCLUSIONS: In phase I, compared to conv-CR alone, multi-CR reduced the incidence of unplanned readmission. Early multidisciplinary CR can reduce hospitalizations and improve long-term prognosis after cardiac surgery.
    Dec. 2019, The Journal of thoracic and cardiovascular surgery, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masato Ogawa, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Kodai Komaki, Kumiko Wakida, Yasuko Gotake, Takeshi Inoue, Hiroshi Tanaka, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P Izawa, Michiko Takahashi, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: Elderly patients undergoing cardiac surgery often show poor nutritional status, muscle wasting, and sarcopenia, which are reported to affect postoperative functional recovery and incidence of complications. Amino acids are essential in maintaining nutritional status, synthesizing muscle protein, and promoting beneficial energy balance of the heart muscle. β-Hydroxy β-methylbutyric acid (HMB) is a leucine metabolite known to increase muscle protein synthesis and inhibit protein catabolism; it has been used to more effectively support patients with muscle wasting due to wearing diseases. However, the efficacy of amino acid administration comprising HMB in patients undergoing open heart surgery remains unclear. This study aims to examine whether preoperative short-term aggressive amino acid administration helps support postoperative recovery of physical function and prevent complications. METHODS: This is a single-center prospective randomized controlled trial (UMIN000030490). Patients aged ≥65 years who will be hospitalized for medical examination before cardiac surgery will be recruited. The participants will be randomly assigned to the experimental or control group. The experimental group will be administered with an amino acid supplement with HMB 1200mg, l-glutamine 7000mg, and l-arginine 7000mg once or twice per day depending on the degree of renal dysfunction, for 14-28 days preoperatively. The control group will not receive any nutritional intervention. The main outcome will be a change in the 6-min walking test distance pre- and postoperatively as a sign of functional recovery. Secondary outcomes such as the incidence of complications; physical, nutritional, and psychological states; mortality; and length of hospital stay will also be evaluated. CONCLUSION: This clinical study will determine the effects of preoperative short-term oral amino acid supplementation with HMB, l-glutamine, and l-arginine on postoperative physical function in elderly patients undergoing cardiac surgery.
    Oct. 2019, Journal of cardiology, 74(4) (4), 360 - 365, English, International magazine
    [Refereed]
    Scientific journal

  • 経皮的大動脈弁植込術患者における基本チェックリストを用いた術前frailty評価はリハビリテーション進行を予測する
    小槇 公大, 小林 成美, 井澤 和大, 坪井 康典, 小川 真人, 後竹 康子, 吉田 尚史, 酒井 良忠, 新家 俊郎, 平田 健一
    (公社)日本理学療法士協会, Aug. 2019, 理学療法学, 46(Suppl.1) (Suppl.1), O - 2, Japanese
    [Refereed]

  • Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Taniguchi Y, Kinutani H, Tsuboi Y, Izawa KP, Satomi-Kobayashi S, Otake H, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata KI
    Background: While hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) can be improved by invasive therapy such as pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA), there has been little data on the health-related quality of life (HRQOL) in such patients. Methods and Results: This single-center and observational study compared the impact of invasive therapy on HRQOL. We utilized the Medical Outcome Study 36-Item Short Health Survey (SF-36) to measure HRQOL and compared HRQOL changes after PEA and BPA. A total of 48 patients were diagnosed with CTEPH. Of these, 39 patients completed questionnaires before and after invasive therapy. The PEA group (n=15) and the BPA group (n=24) had similar improvements in clinical parameters. With regard to HRQOL score, both groups had fairly low scores in physical functioning (PF), role physical (RP), general health (GH), social functioning (SF), role emotional (RE), and physical component summary (PCS) at baseline. PF, GH, vitality (VT), mental health (MH), and PCS had significant improvements in the PEA group while PCS and all subscales except for bodily pain (BP) had significant improvements in the BPA group. Furthermore, changes between baseline and follow-up were not significantly different between the 2 groups. Conclusions: BPA for patients who are ineligible for PEA can recover HRQOL to a similar level to that achieved by PEA.
    2019, Circulation Reports, 1(5) (5), 228 - 234, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Effects of postoperative dietary intake on functional recovery of patients undergoing cardiac surgery
    Ogawa M, Izawa KP, Kobayashi Seimi, Tsuboi Y, Komaki K, Gotake Y, Yoshida N, Wakida K, Uchida J, Sakai Yoshitada, Okita Y
    Jan. 2019, Nutr Metab Cardiovasc Dis, 29(1) (1), 90 - 96, English
    [Refereed]
    Scientific journal

  • 初期臨床研修医を対象としたSOC(Sense of Coherence)によるレジリエンス測定とストレス対処能力自己評価
    木村真希, 在間梓, 坂口一彦, 伊藤智雄, Maniwa Yoshimasa, 河野誠司, Kobayashi Seimi
    (一社)日本医学教育学会, Jul. 2018, 医学教育, 49(Suppl.) (Suppl.), 236 - 236, Japanese
    [Refereed]
    Scientific journal

  • 高齢者における大動脈弁狭窄症術式別の栄養評価
    内田絢子, 小槇公大, 小川真人, 坪井康典, 脇田久美子, 山本育子, 高橋路子, Ogawa Wataru, Kobayashi Seimi, 宇佐美眞
    Jun. 2018, 日本病態栄養学会誌, 21(2) (2), 385 - 393, Japanese
    [Refereed]
    Scientific journal

  • Yanaka K, Nakayama K, Shinke T, Shinkura Y, Taniguchi Y, Kinutani H, Tamada N, Onishi H, Tsuboi Y, Satomi-Kobayashi Seimi, OTAKE HIROMASA, Tanaka H, Okita Y, Emoto N, Hirata Ken-ichi
    BACKGROUND: Residual symptoms after pulmonary endarterectomy (PEA) remain as the clinical issues to be solved. Additional balloon pulmonary angioplasty (BPA) after PEA showed its efficacy with symptoms in a case series, although long-term spontaneous recovery of exercise ability after PEA was also reported. However, no studies have validated the clinical efficacy of additional BPA by directly comparing PEA with and without BPA. The aim of this study was to retrospectively evaluate the efficacy of additional BPA as a sequential hybrid therapy for chronic thromboembolic pulmonary hypertension after PEA. METHODS AND RESULTS: Among 44 patients with chronic thromboembolic pulmonary hypertension, 20 patients had residual symptoms after PEA. Of those, 10 patients underwent additional BPA (hybrid group) and were compared with the other 10 patients, who were followed up without BPA (PEA group). The period from PEA to additional BPA was 7.3±2.3 months. In hybrid group, mean pulmonary arterial pressure was significantly improved by PEA (40.6±1.8 to 26.9±3.1 mm Hg, P=0.001) and improved further (to 16.7±1.8 mm Hg, P=0.002) with additional BPA, which resulted in remarkable improvement in World Health Organization (WHO) functional class (pre- to post-BPA: class I/II/III/IV, 0/5/4/1 to 7/3/0/0; P<0.001). Compared with the PEA group at follow-up, the hybrid group achieved better mean pulmonary arterial pressure (18.7±1.7 versus 30.2±3.2 mm Hg, P=0.008), WHO functional class (class I/II/III/IV, 7/3/0/0 versus 0/8/2/0; P=0.001), and 6-minute walking distance (429±38 versus 319±22 m, P=0.028). CONCLUSIONS: A sequential hybrid strategy improved residual symptoms and exercise capacity compared with single-PEA therapy.
    Jun. 2018, J Am Heart Assoc., 7(13) (13), English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Early Introduction of Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients With Chronic Thromboembolic Pulmonary Hypertension.
    Tamada N, Nakayama K, Yanaka K, Onishi H, Shinkura Y, Tsuboi Y, Izawa KP, Satomo-Kobayashi Seimi, Otake Hiromasa, Tanaka H, Shinke T, Okita Y, Emoto N, Hirata Ken-ichi
    Jun. 2018, JACC Cardiovasc Interv., 11(11) (11), 1114 - 1116, English
    [Refereed]
    Scientific journal

  • Hiroki Konishi, Koji Fukuzawa, Shumpei Mori, Seimi Satomi-Kobayashi, Kunihiko Kiuchi, Atsushi Suzuki, Tomomi Akita, Yoshihiko Yano, Akihiro Yoshida, Ken-Ichi Hirata
    Apr. 2018, Internal medicine (Tokyo, Japan), 57(8) (8), 1189 - 1189, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング
    岡野光真, Hara Tetsuya, 渡部晃一, 尾下寿彦, 津田成康, 入野康宏, 小林成美, 篠原正和, 杜隆嗣, 石田達郎, 平田健一
    日本臨床分子医学会, Apr. 2018, 日本臨床分子医学会学術総会プログラム・抄録集 55回, 55回, 58 - 58, Japanese

  • Yuto Shinkura, Kazuhiko Nakayama, Kenichi Yanaka, Hiroto Kinutani, Naoki Tamada, Yasunori Tsuboi, Seimi Satomi-Kobayashi, Hiromasa Otake, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
    EuroPCR, Apr. 2018, EuroIntervention, 13(17) (17), 2060 - 2068, English
    [Refereed]
    International conference proceedings

  • 再構成HDLのphospholipid組成はその抗炎症作用に影響する(Phospholipid Composition of Reconstitute High Density Lipoproteins Affects Their Anti-inflammatory Effects)
    岡野 光真, 入野 康宏, 篠原 正和, 田中 伸明, 尾下 寿彦, 津田 成康, 渡部 晃一, 森 健太, 原 哲也, 小林 成美, 杜 隆嗣, 石田 達郎, 平田 健一
    (一社)日本循環器学会, Mar. 2018, 日本循環器学会学術集会抄録集, 82回, PJ015 - 1, English

  • Masato Ogawa, Kazuhiro P Izawa, Seimi Satomi-Kobayashi, Aki Kitamura, Yasunori Tsuboi, Kodai Komaki, Rei Ono, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita
    BACKGROUND: Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial but has not been fully explored. AIMS: The aim of this study was to determine the predictive value of the assessment of preoperative exercise capacity for POD. METHODS: We enrolled 313 consecutive patients (mean age, 68.6 ± 14.8 years) undergoing elective cardiac surgery. We measured physical functions such as the 6-minute walking distance (6MWD) and Timed Up-and-Go test (TUG) before surgery. The assessment of delirium was conducted every 8 h from the day of surgery to 5 days after surgery using the Intensive Care Delirium Screening Checklist. RESULTS: POD occurred in 46 patients (14.6%). Age, 6MWD, TUG, serum hemoglobin, estimated glomerular filtration rate, and length of intensive care unit stay were significantly different based on the presence or absence of POD (p < 0.05 for each). After multivariate analysis, 6MWD remained a statistically significant indicator for developing POD (OR 0.98; p = 0.02). The cut-off value of 6MWD for predicting POD was 345 m (AUC = 0.75; p = 0.001). CONCLUSIONS: Poor exercise capacity was found to be an independent predictor of POD following elective cardiac surgery. This finding suggests the importance of preoperative functional evaluation in the prevention and management of POD in cardiac surgery patients.
    Jan. 2018, Aging clinical and experimental research, 30(1) (1), 27 - 34, English, International magazine
    [Refereed]
    Scientific journal

  • 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討
    脇田久美子, 三ヶ尻礼子, 田渕聡子, 山西美沙, 赤毛弘子, 玉田萌子, 西田ひかる, 中谷早希, 金谷沙紀, 森智子, 向山万為子, 中村美仁, 山本育子, 松田佳子, 高橋路子, 小川渉, Kobayashi Seimi, 石田達郎, 大瀬良知子, 栗原伸公
    Jan. 2018, 日本病態栄養学会誌, 21(Supple) (Supple), 125, Japanese
    Symposium

  • Masato Ogawa, Kazuhiro P. Izawa, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Kodai Komaki, Yasuko Gotake, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita
    Public Library of Science, Dec. 2017, PLoS ONE, 12(12) (12), e0190359., English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasunori Tsuboi, Hidekazu Tanaka, Ryo Nishio, Takuma Sawa, Daisuke Terashita, Kazuhiko Nakayama, Seimi Satomi-Kobayashi, Yoshitada Sakai, Noriaki Emoto, Ken-ichi Hirata
    Sep. 2017, JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION, 37(5) (5), 341 - 346, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shota Yamana, Amina Tokiyama, Hidenobu Fujita, Yuya Terao, Sayo Horibe, Naoto Sasaki, Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yoshiyuki Rikitake
    Aug. 2017, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 490(2) (2), 169 - 175, English
    [Refereed]
    Scientific journal

  • Extensive revascularization by balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension beyond hemodynamic normalization
    ShinkuraY, Nakayama Kazuhiko, YanakaK, KinutaniH, TamadaN, TsuboiY, Kobayashi Seimi, OtakeH, ShinkeT, EmotoN, Hirata Ken-ichi
    Aug. 2017, EuroIntervention, English
    [Refereed]
    Scientific journal

  • Yuya Terao, Hidenobu Fujita, Sayo Horibe, Junya Sato, Satomi Minami, Miwako Kobayashi, Ichiro Matsuoka, Naoto Sasaki, Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yoshiyuki Rikitake
    May 2017, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 486(3) (3), 811 - 816, English
    [Refereed]
    Scientific journal

  • Masato Ogawa, Kazuhiro P. Izawa, Seimi Satomi-Kobayashi, Aki Kitamura, Rei Ono, Yoshitada Sakai, Yutaka Okita
    Apr. 2017, AGING CLINICAL AND EXPERIMENTAL RESEARCH, 29(2) (2), 283 - 290, English
    [Refereed]
    Scientific journal

  • 開心術後患者における退院時身体機能と主要有害心血管イベントとの関連
    小槇 公大, 小林 成美, 小川 真人, 坪井 康典, 井澤 和大, 後竹 康子, 寺下 大輔, 田中 裕史, 酒井 良忠, 平田 健一, 大北 裕
    (一社)日本循環器学会, Mar. 2017, 日本循環器学会学術集会抄録集, 81回, CO - 10, Japanese

  • Changes in Exercise Capacity and Psychosocial Factors in Hospitalized Cardiac Surgery Patients
    IZAWA P. KAZUHIRO
    2017, Research in Cardiovascular Medicine, 6(4) (4), 38 - 44, English
    [Refereed]
    Scientific journal

  • Hiroki Konishi, Koji Fukuzawa, Shumpei Mori, Seimi Satomi-Kobayashi, Kunihiko Kiuchi, Atsushi Suzuki, Yoshihiko Yano, Akihiro Yoshida, Ken-ichi Hirata
    2017, INTERNAL MEDICINE, 56(14) (14), 1771 - 1779, English
    [Refereed]
    Scientific journal

  • Yasuhiro Irino, Ryuji Toh, Manabu Nagao, Takeshige Mori, Tomoyuki Honjo, Masakazu Shinohara, Shigeyasu Tsuda, Hideto Nakajima, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, Okiko Miyata, Ken-Ichi Hirata
    Nov. 2016, SCIENTIFIC REPORTS, 6, 36749, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 高齢開心術施行患者における転帰に対する術前身体機能測定の意義
    小槇 公大, 井澤 和大, 小川 真人, 上田 雄也, 北村 アキ, 小林 成美, 佐和 琢磨, 寺下 大輔, 酒井 良忠, 平田 健一, 大北 裕
    (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), O - 2, Japanese

  • 待機的心臓手術患者において術前身体活動は術後せん妄を予測する
    小川 真人, 井澤 和大, 北村 アキ, 小林 成美, 小槇 公大, 小野 玲, 酒井 良忠, 平田 健一, 大北 裕
    (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), O - 4, Japanese
    [Refereed]

  • Mitsuo Kinugasa, Shumpei Mori, Tomofumi Takaya, Tatsuro Ito, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sei Fujiwara, Tatsuya Nishii, Atsushi K. Kono, Yutaka Okita, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), Oct. 2016, Journal of Cardiology, 68(4) (4), 308 - 315, English
    [Refereed]
    Scientific journal

  • Manabu Nagao, Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Hideto Nakajima, Tetsuya Hara, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Hidekazu Tanaka, Tatsuro Ishida, Ken-ichi Hirata
    Jul. 2016, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 475(4) (4), 322 - 328, English
    [Refereed]
    Scientific journal

  • 小槇 公大, 井澤 和大, 小川 真人, 上田 雄也, 北村 アキ, 小林 成美, 佐和 琢磨, 寺下 大輔, 酒井 良忠, 平田 健一, 大北 裕
    【はじめに，目的】近年，我が国においては，医療制度改革に伴い平均在院日数は短縮されている。一方，待機的開心術を施行される高齢者は，増加傾向にある。高齢者の開心術では，術後早期より積極的に離床を進めても，それに難渋し，自宅退院が困難となる例もある。先行研究（Edgerton, et al., 2013）では，手術のリスクスコアが高値であった開心術患者は，低値のそれに比し，自宅退院率は低いことが示されている。しかし，待機的開心術を施行された高齢患者における術前身体機能と自宅退院に関する報告は極めて少ない。本研究の目的は，高齢開心術患者における転帰に対する予測因子について明らかにすることである。【方法】対象は，2013年7月から2015年9月までに，当院心臓血管外科にて待機的開心術かつ術前身体機能の評価が施行された，65歳以上の高齢者，連続84例である。我々は，全84例を自宅退院群と施設転院群に選別し，術前の年齢，性別，体格指数，併存疾患，血液生化学検査として脳性ナトリウム利尿ペプチド，ヘモグロビン値，アルブミン値，推定糸球体濾過量，心エコーによる心機能，Euro SCORE II，手術時間，術中水分バランス，大動脈遮断時間，独居の有無および身体機能について群間で比較した。術前身体機能の指標は，握力，膝伸展筋力，Short Physical Performance Battery（SPPB）である。統計学的手法として我々は，群間比較に，Mann-WhitneyのU検定とカイ2乗検定を用いた。また，群間で有意な差を認めた項目を説明変数，自宅退院を目的変数とする多変量ロジスティック回帰分析を実施した。さらに，有意であった項目に関しては，Receiver operating characteristic曲線より抽出された独立因子のカットオフ値および感度，特異度を算出した。統計学的有意差判定の基準は5%未満である。【結果】自宅退院群は71例（年齢76.1±6.7歳，男性52％），施設転院群は13例（年齢79.9±6.2歳，男性54％）であった。自宅退院群は施設転院群に比し，術前の脳性ナトリウム利尿ペプチドは低値（P=0.04），血清アルブミン値は高値（P=0.002），SPPBは高値（P=0.003）を示した。回帰分析の結果，SPPB（オッズ比1.41，95%信頼区間1.01-2.03，P=0.04）が独立因子として抽出された。また，自宅退院のためのカットオフ値は，10点（感度0.88，特異度0.54，Area under the curve=0.73）であった。【結論】本研究結果より，術前SPPBは，高齢開心術施行患者の転帰を予測する独立因子であることが示された。
    公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 1176 - 1176, Japanese

  • 小川 真人, 井澤 和大, 北村 アキ, 小林 成美, 小槇 公大, 小野 玲, 酒井 良忠, 平田 健一, 大北 裕
    【はじめに，目的】心臓手術後せん妄の発生率は10～28％と報告されており，高頻度で起こる合併症である。術後せん妄による弊害として，死亡率の増加や身体機能，認知機能の長期的な悪化が報告されている。一方，周術期における多面的予防介入でせん妄発生頻度は低下すると報告もある。以上より，術後せん妄のリスク因子を術前から把握することは重要であると考えられる。先行研究では，せん妄の術前リスク因子として，加齢，腎機能障害そして低栄養等が報告されている。しかし，術前の身体活動と術後せん妄の関係についての報告は極めて少ない。そこで，本研究の目的は術前の身体活動と術後せん妄との関係について明らかにすることである。【方法】対象は，2013年11月から2015年3月までに当院心臓血管外科にて人工心肺を用いた待機的開心術を受け，かつ術前評価を実施した連続患者144名である。せん妄の発生率の調査にはIntensive Care Delirium Screening Checklist（ICDSC）を用い，術後5日間，8時間ごとに調査した。ICDSCの評価のうち，一度でも4点以上の点数が付いたものをせん妄あり，全ての評価で3点以下のものをせん妄なしと評価し，せん妄発症の有無により，2群に分け，比較検討を行った。術前の身体活動の指標としてはLife Space Assessment（LSA）を用い，術前1ヶ月の身体活動を調査した。その他，術前および周術期の臨床的患者背景因子は，診療記録より調査した。統計学的解析方法として，群間比較にはt検定，カイ2乗検定を実施し，さらに群間比較で有意であった項目を説明変数，せん妄の発生を目的変数とするロジスティック回帰分析を実施した。また，有意であった項目に関してはROC曲線を作成し，カットオフ値を算出した。有意水準は5%未満とした。【結果】せん妄の発生率は9.7%（144名中14名）であった。年齢，Bod Mass Index，性別，左室駆出率，脳性ナトリウム利尿ペプチド，併存疾患，EuroscoreII，術式，手術時間，麻酔時間，大動脈遮断時間には有意差を認めなかった。せん妄なし群と比較し，せん妄あり群のLSAは有意に低値を示した（82.5±35.7 vs. 55.3±29.4；p=0.01）。術前ヘモグロビン値，推定糸球体濾過量はせん妄なし群に比してせん妄あり群で低値を示した（p＜0.05）。また術後集中治療室在室日数はせん妄なし群に比してせん妄あり群で有意に遅延していた（p=0.01）。せん妄を目的変数とする多重ロジスティック回帰分析の結果，LSAのみが抽出された（オッズ比0.98；p=0.04）。術後せん妄を予測するLSAのカットオフ値は84であった（AUC；0.82，感度90%，特異度63%，p=0.002）。【結論】術前の身体活動低値，生活空間の狭小化は心臓手術後せん妄発症の独立した危険因子であることが示された。術前身体活動の把握並びに増大は，術後せん妄発症の予防やリスクの層別化に有用である。
    公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 1168 - 1168, Japanese

  • Cardiac Rehabilitation and Assessment of Exercise Capacity in the Treatment of Pulmonary Hypertension: Suggestions for Long-term Intervention from Diagnosis to Recovery Phase
    IZAWA P. KAZUHIRO
    日本心臓リハビリテーション学会 ; [1996]-, 2016, 心臓リハビリテーション, 21(4) (4), 164 - 169, Japanese
    [Refereed]
    Scientific journal

  • Masato Ogawa, Kazuhiro P. Izawa, Aki Kitamura, Rei Ono, Seimi Satomi-Kobayashi, Yoshitada Sakai, Yutaka Okita
    Dec. 2015, INTERNATIONAL JOURNAL OF CARDIOLOGY, 201, 154 - 156, English
    [Refereed]
    Scientific journal

  • Yuya Terao, Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yoshiyuki Rikitake
    Aug. 2015, CARDIOVASCULAR DIABETOLOGY, 14, 104, English
    [Refereed]
    Scientific journal

  • Shumpei Mori, Tomofumi Takaya, Mitsuo Kinugasa, Tatsuro Ito, Sachiko Takamine, Sei Fujiwara, Tatsuya Nishii, Atsushi K. Kono, Takeshi Inoue, Seimi Satomi-Kobayashi, Yoshiyuki Rikitake, Yutaka Okita, Ken-ichi Hirata
    Apr. 2015, ATHEROSCLEROSIS, 239(2) (2), 622 - 628, English
    [Refereed]
    Scientific journal

  • Junya Sato, Mitsuo Kinugasa, Seimi Satomi-Kobayashi, Kinta Hatakeyama, Aaron J. Knox, Yujiro Asada, Margaret E. Wierman, Ken-ichi Hirata, Yoshiyuki Rikitake
    Sep. 2014, PLOS ONE, 9(9) (9), e107236, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Fumie Kureha, Seimi Satomi-Kobayashi, Yoshiki Kubo, Mitsuo Kinugasa, Tatsuro Ishida, Yoshimi Takai, Ken-ichi Hirata, Yoshiyuki Rikitake
    Jun. 2013, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(6) (6), 1206 - +, English
    [Refereed]
    Scientific journal

  • Hideto Nakajima, Tatsuro Ishida, Seimi Satomi-Kobayashi, Kenta Mori, Tetsuya Hara, Naoto Sasaki, Tomoyuki Yasuda, Ryuji Toh, Hidekazu Tanaka, Hiroya Kawai, Ken-ichi Hirata
    May 2013, HYPERTENSION, 61(5) (5), 1002 - +, English
    [Refereed]
    Scientific journal

  • Seimi Satomi-Kobayashi, Mitsuo Kinugasa, Reiko Kobayashi, Kinta Hatakeyama, Yusuke Kurogane, Tatsuro Ishida, Noriaki Emoto, Yujiro Asada, Yoshimi Takai, Ken-ichi Hirata, Yoshiyuki Rikitake
    Aug. 2012, JOURNAL OF BIOLOGICAL CHEMISTRY, 287(36) (36), 30336 - 30345, English
    [Refereed]
    Scientific journal

  • Mitsuo Kinugasa, Hisayuki Amano, Seimi Satomi-Kobayashi, Kazuhiko Nakayama, Muneaki Miyata, Yoshiki Kubo, Yuichi Nagamatsu, Yusuke Kurogane, Fumie Kureha, Shota Yamana, Ken-ichi Hirata, Jun Miyoshi, Yoshimi Takai, Yoshiyuki Rikitake
    Mar. 2012, CIRCULATION RESEARCH, 110(5) (5), 716 - U197, English
    [Refereed]
    Scientific journal

  • Hideto Tawa, Yoshiyuki Rikitake, Motonori Takahashi, Hisayuki Amano, Muneaki Miyata, Seimi Satomi-Kobayashi, Mitsuo Kinugasa, Yuichi Nagamatsu, Takashi Majima, Hisakazu Ogita, Jun Miyoshi, Ken-ichi Hirata, Yoshimi Takai
    Jun. 2010, CIRCULATION RESEARCH, 106(11) (11), 1731 - U143, English
    [Refereed]
    Scientific journal

  • Seimi Satomi-Kobayashi, Tomomi Ueyama, Steffen Mueller, Ryuji Toh, Tomoya Masano, Tsuyoshi Sakoda, Yoshiyuki Rikitake, Jun Miyoshi, Hiroaki Matsubara, Hidemasa Oh, Seinosuke Kawashima, Ken-ichi Hirata, Yoshimi Takai
    Oct. 2009, HYPERTENSION, 54(4) (4), 825 - U268, English
    [Refereed]
    Scientific journal

  • Plasma Tetrahydrobiopterin/Dihydrobiopterin Ratio - A Possible Marker of Endothelial Dysfunction
    Masafumi Takeda, Tomoya Yamashita, Masakazu Shinohara, Naoto Sasaki, Tomofumi Takaya, Kenji Nakajima, Nobutaka Inoue, Tomoya Masano, Hideto Tawa, Seimi Satomi-Kobayashi, Ryuji Toh, Daisuke Sugiyama, Kunihiro Nishimura, Mitsuhiro Yokoyama, Ken-ichi Hirata, Seinosuke Kawashima
    May 2009, CIRCULATION JOURNAL, 73(5) (5), 955 - 962, English
    [Refereed]
    Scientific journal

  • Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats - The possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase
    Tomoya Masano, Seinosuke Kawashima, Ryuji Toh, Seimi Satomi-Kobayashi, Masakazu Shinohara, Tornofumi Takaya, Naoto Sasaki, Masafumi Takeda, Hideto Tawa, Tomoya Yamashita, Mitsuhiro Yokoyama, Ken-ichi Hirata
    Sep. 2008, CIRCULATION JOURNAL, 72(9) (9), 1512 - 1519, English
    [Refereed]
    Scientific journal

  • T Honjo, N Inoue, R Shiraki, S Kobayashi, K Otsui, M Takahashi, K Hirata, S Kawashima, H Yokozaki, M Yokoyama
    2006, JOURNAL OF VASCULAR RESEARCH, 43(2) (2), 131 - 138, English
    Scientific journal

  • J Ejiri, N Inoue, S Kobayashi, R Shiraki, K Otsui, T Honjo, M Takahashi, Y Ohashi, S Ichikawa, M Terashima, T Mori, K Awano, T Shinke, J Shite, K Hirata, H Yokozaki, S Kawashima, M Yokoyama
    Oct. 2005, CIRCULATION, 112(14) (14), 2114 - 2120, English
    Scientific journal

  • J Ejiri, N Inoue, T Tsukube, T Munezane, Y Hino, S Kobayashi, K Hirata, S Kawashima, S Imajoh-Ohmi, Y Hayashi, H Yokozaki, Y Okita, M Yokoyama
    Oct. 2003, CARDIOVASCULAR RESEARCH, 59(4) (4), 988 - 996, English
    [Refereed]
    Scientific journal

  • S Kobayashi, N Inoue, Y Ohashi, M Terashima, K Matsui, T Mori, H Fujita, K Awano, K Kobayashi, H Azumi, J Ejiri, K Hirata, S Kawashima, Y Hayashi, H Yokozaki, H Itoh, M Yokoyama
    Aug. 2003, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 23(8) (8), 1398 - 1404, English
    [Refereed]
    Scientific journal

  • Y Rikitake, K Hirata, T Yamashita, K Iwai, S Kobayashi, H Itoh, M Ozaki, J Ejiri, M Shiomi, N Inoue, S Kawashima, M Yokoyama
    Dec. 2002, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 22(12) (12), 2049 - 2053, English
    [Refereed]
    Scientific journal

  • H Azumi, N Inoue, Y Ohashi, M Terashima, T Mori, H Fujita, K Awano, K Kobayashi, K Maeda, K Hata, T Shinke, S Kobayashi, K Hirata, S Kawashima, H Itabe, Y Hayashi, S Imajoh-Ohmi, H Itoh, M Yokoyama
    Nov. 2002, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 22(11) (11), 1838 - 1844, English
    [Refereed]
    Scientific journal

  • Tomoya Yamashita, Seinosuke Kawashima, Masanori Ozaki, Masayuki Namiki, Seimi Satomi-Kobayashi, Tadashi Seno, Yasuaki Matsuda, Nobutaka Inoue, Ken-Ichi Hirata, Hozuka Akita, Keiji Umetani, Etsuro Tanaka, Hidezo Mori, Mitsuhiro Yokoyama
    Academic Press Inc., 2001, Nitric Oxide - Biology and Chemistry, 5(5) (5), 494 - 503, English
    [Refereed]
    Scientific journal

■ MISC
  • Hypercholesterolemia with Heterozygous Pathogenic Mutations in ABCG5 Genes
    藤岡知夫, 石田達郎, 小林成美, 篠原正和, 西森誠, 長尾学, 吉川祥子, 飯野琢也, 朝倉絢子, 瀬戸悠太郎, 桑原直也, 多田隼人, 小島信子, 高村雅之, 平田健一, 杜隆嗣
    2024, 日本循環器学会学術集会(Web), 88th

  • Effectiveness of ezetimibe and colestimide against hypercholesterolemia associated with heterozygous mutations of ABCG5 or 8
    藤岡知夫, 杜隆嗣, 桑原直也, 長尾学, 篠原正和, 小林成美, 石田達郎, 平田健一
    2024, 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web), 56th

  • 血中cystine/methionine比とHFpEF患者における左室拡張機能との関連
    朝倉絢子, 長尾学, 篠原正和, 篠原正和, 西森誠, 吉川祥子, 飯野琢也, 田中秀和, 小林成美, 石田達郎, 平田健一, 平田健一, 杜隆嗣
    2023, 日本腫瘍循環器学会学術集会抄録集(Web), 6th

  • コロナ禍の中で進める新たな地域連携~CURE-KOBEでの理学療法士の立場から
    岩田健太郎, 北井豪, 村井亮介, 立川良, 尾原信行, 谷知子, 小林成美, 井澤和大, 山根光量, 富井啓介, 古川裕, 細谷亮, 幸原伸夫
    2023, 日本循環器学会学術集会(Web), 87th

  • Efforts to improve the junior residency training system in Kobe University Hospital.
    木村真希, 小林成美, 木戸正浩, 坂口一彦, 河野誠司, 児玉裕三
    2023, 医学教育, 54(Suppl.) (Suppl.)

  • Masato Ogawa, Seimi Satomi-Kobayashi, Kazuhiro P. Izawa, Ken-ichi Hirata
    Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), 01 Mar. 2021, Journal of Cardiology, 77(3) (3), 320 - 321, English
    Report scientific journal

  • 心疾患に対する理学療法~時代の変遷とともに~
    井澤和大, 小林成美, 小川真人, 小川真人, 平野康之, 酒井良忠
    2021, 近畿理学療法学術大会抄録集(CD-ROM), 61st (Web)

  • Assessment of Microvasculopathy in Chronic Thromboembolic Pulmonary Hypertension after Interventional Treatment
    大西裕之, 谷口悠, 住本恵子, 松岡庸一郎, 伊澤有, 坪井康典, 鳥羽敬義, 大竹寛雅, 小林成美, 江本憲昭, 平田健一
    2020, 日本循環器学会学術集会(Web), 84th

  • 酸化ストレスに対するα-ケトグルタル酸の心筋細胞保護作用
    渡部 晃一, 杜 隆嗣, 西森 誠, 岡野 光真, 入野 康宏, 原 哲也, 篠原 正和, 小林 成美, 石田 達郎, 平田 健一
    (一社)日本心臓病学会, Sep. 2019, 日本心臓病学会学術集会抄録, 67回, P - 206, Japanese

  • 新規採用初期臨床研修医を対象とした基本的技術トレーニング研修の取り組み
    木村 真希, 坂口 一彦, 伊藤 智雄, 眞庭 謙昌, 小林 成美, 小林 和幸, 宮良 高雄, 八幡 眞理子, 大路 剛, 今西 孝充, 横山 朋大, 加藤 博史, 大原 彰子, ウィリアムソン 彰子, 河野 誠司
    (一社)日本医学教育学会, Jul. 2019, 医学教育, 50(Suppl.) (Suppl.), 154 - 154, Japanese

  • Establishment of Femoral Vein Ligation Model: a New DVT Imaging Model
    Tetsuya Hara, Mitsumasa Okano, Makoto Nishimori, Koichi Watanabe, Yasuhiro Irino, Seimi Kobayashi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
    May 2019, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39, English
    Summary international conference

  • HDL機能性の新しい指標であるコレステロール取り込み能とコレステロール排出能の冠動脈プラーク特性に関連した比較(Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL-functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties)
    尾下 寿彦, 杜 隆嗣, 岡野 光真, 渡部 晃一, 西森 誠, 永野 雄一朗, 原田 周, 村上 克洋, 桐山 真利亜, 吉川 景子, 三輪 桂子, 小林 成美, 篠原 正和, 原 哲也, 入野 康宏, 大竹 寛雅, 石田 達郎, 平田 健一
    (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, PJ100 - 3, English

  • Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, vs. Cholesterol Efflux Capacity in Association With Coronary Plaque Lipid Burden.
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Kouichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Keiko Yoshikawa, Keiko Miwa, Seimi Kobayashi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata
    06 Nov. 2018, CIRCULATION, 138, English
    Summary international conference

  • Establishment of Novel Deep Venous Thrombosis Model Suitable for In Vivo Imaging.
    Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Seimi Kobayashi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
    06 Nov. 2018, CIRCULATION, 138, English
    Summary international conference

  • Reduction of 5-ipoxygenase Derived Docosahexaenoic Acid Metabolites Under Social Mental Stress: Their Function for Maintenance of Heme Oxygenase-1 Expression in Macrophage
    Makoto Nishimori, Masakazu Shinohara, Kouichi Watanabe, Mitsumasa Okano, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Yasuhiro Irino, Seimi Kobayashi, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata
    06 Nov. 2018, CIRCULATION, 138, English
    Summary international conference

  • 高血圧患者における食塩摂取量簡易評価方法の検討
    脇田久美子, 脇田久美子, 三ヶ尻礼子, 田渕聡子, 山西美沙, 山下弘子, 玉田萌子, 西田ひかる, 山本育子, 松田佳子, 松田佳子, 高橋路子, 高橋路子, 小川渉, 小川渉, 小林成美, 杜隆嗣, 石田達郎, 大瀬良知子, 栗原伸公
    2018, 日本静脈経腸栄養学会雑誌, 33(1) (1)

  • Seimi Satomi-Kobayashi, Tatsuro Ishida
    Japan Atherosclerosis Society, 2018, Journal of Atherosclerosis and Thrombosis, 25(2) (2), 128 - 130, English
    [Refereed]
    Introduction scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • ラミニンによるアストロサイトの突起形成促進にはジストログリカンとα‐シントロフィンを介したAQP4の発現が関与する
    中江友軌, 堀部紗世, 井上咲那, 宇野槙優, 後藤麻友, 西岡詩織, 佐藤淳哉, 河内正二, 佐々木直人, 小林成美, 平田健一, 力武良行
    生命科学系学会合同年次大会運営事務局, Dec. 2017, 日本生化学会大会(Web), 90th, ROMBUNNO.1P‐1187 (WEB ONLY) - 1187], Japanese

  • Masato Ogawa, Kazuhiro Izawa, Seimi Kobayashi, Yasunori Tsuboi, Kodai Komaki, Yasuko Gotake, Hiroshi Tanaka, Ken-Ichi Hirata, Yoshitada Sakai, Yutaka Okita
    Sep. 2016, JOURNAL OF CARDIAC FAILURE, 22(9) (9), S190 - S190, English
    Summary international conference

  • 【最新冠動脈疾患学(上)-冠動脈疾患の最新治療戦略-】 冠動脈疾患の発症予測と早期治療介入の現状と課題
    小林成美, Hirata Ken-ichi
    Jun. 2016, 日本臨床, 74(増刊4 最新冠動脈疾患学(上)) (増刊4 最新冠動脈疾患学(上)), 19 - 24, Japanese
    [Invited]
    Introduction commerce magazine

  • [Predictive diagnosis and early therapeutic intervention for coronary artery disease: current status and issues]
    Kobayashi Seimi, HirataKI
    Jun. 2016, Nihon Rinsho, 74(Suppl 4 Pt 1) (Suppl 4 Pt 1), 19 - 24, English
    Introduction commerce magazine

  • Poor Exercise Capacity is Associated with the Prevalence of Postoperative Delirium in Elective Cardiac Surgery
    Masato Ogawa, Kazuhiro Izawa, Aki Kitamura, Seimi Kobayashi, Yasunori Tsuboi, Kodai Komaki, Takuma Sawa, Ken-Ichi Hirata, Yutaka Okita
    Oct. 2015, JOURNAL OF CARDIAC FAILURE, 21(10) (10), S165 - S165, English
    Summary international conference

  • Efficacy of Evaluating Exercise Tolerance Before and after Cardiac Surgery
    Aki Kitamura, Seimi Kobayashi, Masato Ogawa, Kazuhiro Izawa, Yutaka Okita
    Oct. 2015, JOURNAL OF CARDIAC FAILURE, 21(10) (10), S165 - S165, English
    Summary international conference

  • Cardiopulmonary Exercise Testing is Variable for Assessing Exercise Capacity and Hemodynamic Status in Patients with Chronic Thromboembolic Pulmonary Hypertension
    Yasunori Tsuboi, Seimi Satomi-Kobayashi, Hidekazu Tanaka, Kazuhiko Nakayama, Noriaki Emoto, Ken-Ichi Hirata
    Oct. 2015, JOURNAL OF CARDIAC FAILURE, 21(10) (10), S148 - S148, English
    Summary international conference

  • Serum Phosphate Level is a Predictive Marker for Aortic Calcification in Patients Without End-stage Renal Disease
    Mitsuo Kinugasa, Tomofumi Takaya, Shumpei Mori, Akira Kasamatsu, Kazuhiro Kashio, Tatsuro Ito, Sachiko Takamine, Seimi Satomi-Kobayashi, Sei Fujiwara, Tatsuya Nishii, Atsushi K. Kono, Ken-ichi Hirata
    Nov. 2014, CIRCULATION, 130, English
    Summary international conference

  • Circulating Levels of 2-Aminobutyric Acid Reflect Myocardial Redox State in Patients With Atrial Septal Defects
    Yasuhiro Irino, Ryuji Toh, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Toshiro Shinke, Tatsuro Shift, Okiko Miyata, Ken-Ichi Hirata
    Nov. 2014, CIRCULATION, 130, English
    Summary international conference

  • 2-Aminobutyric Acid, a Potential Indicator of Oxidative Stress in Failing Hearts
    Ryuji Toh, Yasuhiro Irino, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Seimi Satomi-Kobayashi, Tatsuro Ishida, Okiko Miyata, Ken-Ichi Hirata
    Oct. 2014, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S186 - S186, English
    Summary international conference

  • GCMSを用いた心不全バイオマーカー探索
    入野 康宏, 杜 隆嗣, 森 健茂, 長尾 学, 本庄 友行, 小林 成美, 新家 俊郎, Ishida Tatsuro, 宮田 興子, Hirata Ken-ichi
    Sep. 2014, JSBMS Letters, 39(Suppl.) (Suppl.), 66, Japanese
    Meeting report

  • Endothelial Lipase in the Heart Modulates Pressure Overload-Induced Heart Failure through Fatty Acid Utilization
    Hideto Nakajima, Tatsuro Ishida, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Li Sun, Ryuji Toh, Seimi Kobayashi, Ken-Ichi Hirata
    Nov. 2012, CIRCULATION, 126(21) (21), English
    Summary international conference

  • Nectin-like Molecule-5 Regulates Formation of Intimal Thickening in Mouse Carotid Artery and Phenotypic Reversion of Vascular Smooth Muscle Cells
    Fumie Kureha, Seimi Satomi-Kobayashi, Mitsuo Kinugasa, Jun Miyoshi, Yoshimi Takai, Ken-ichi Hirata, Yoshiyuki Rikitake
    Nov. 2012, CIRCULATION, 126(21) (21), English
    Summary international conference

  • 【災害医療と血圧管理】 災害後の慢性期における血圧管理
    Kobayashi Seimi, Hirata Kenichi
    Aug. 2011, 血圧, 18巻, 8号, pp. 761-764, Japanese
    Introduction scientific journal

  • 免疫グロブリン様分子Necl‐5による血管新生の制御
    宮田宗明, 力武良行, 天野恭志, 衣笠允雄, 小林成美, 永松裕一, 武田匡史, 三好淳, 平田健一, 高井義美
    2010, 生化学, ROMBUNNO.1P-0477, Japanese

  • Immunoglobulin-like Cell Adhesion Molecule Necl-5 Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis by Controlling the Interaction Between VEGFR2 and Integrin alpha v beta 3
    Mitsuo Kinugasa, Yoshiyuki Rikitake, Hisayuki Amano, Seimi Satomi-Kobayashi, Hideto Tawa, Fumie Kureha, Yusuke Kurogane, Yuichi Nagamatsu, Jun Miyoshi, Yoshimi Takai, Ken-ichi Hirata
    Nov. 2009, CIRCULATION, 120(18) (18), S1115 - S1116, English
    Summary international conference

  • PE-087 Plasma pteridine level as a biomarker of cardiovascular diseases(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Takeda Masafumi, Shinohara Masakazu, Yamashita Tomoya, Sasaki Naoto, Tawa Hideto, Nakajima Kenji, Masano Tomoya, Toh Ryuji, Kobayashi Seimi, Kawashima Seinosuke, Hirata Kenichi
    Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 381 - 381, English

  • OE-168 Inhibition of Myocardin Deteriorates Cardiac Function under Beta-Adrenergic Stimulation(Molecular biology, myocardium (M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Kobayashi Seimi, Ueyama Tomomi, Toh Ryuji, Masano Tomoya, Sakoda Tsuyoshi, Matsubara Hiroaki, Oh Hidemasa, Hirata Kenichi
    Japanese Circulation Society, 01 Mar. 2008, Circulation journal : official journal of the Japanese Circulation Society, 72, 222 - 222, English

  • FRS-104 Plasma Biopterin Levels as a Biomarker of Endothelial Dysfunction(Biomarker of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Takeda Masafumi, Shinohara Masakazu, Yamashita Tomoya, Sasaki Naoto, Tawa Hideto, Shiraki Rio, Toh Ryuji, Masano Tomoya, Kobayashi Seimi, Kawashima Seinosuke, Hirata Kenichi, Yokoyama Mitsuhiro
    Japanese Circulation Society, 01 Mar. 2007, Circulation journal : official journal of the Japanese Circulation Society, 71, 146 - 146, English

  • Augmentation of vascular remodeling due to uncoupled eNOS in diabetes
    Naoto Sasaki, Seinosuke Kawashima, Masafumi Takeda, Tomoya Masano, Tomofumi Takaya, Masakazu Shinohara, Rio Shiraki, Ryuji Toh, Seimi Kobayashi, Tomoya Yamashita, Mitsuhiro Yokoyama
    Oct. 2006, CIRCULATION, 114(18) (18), 152 - 152, English
    Summary international conference

  • Letter regarding article by Ejiri et al, "Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease" - Response
    N Inoue, J Ejiri, S Kobayashi, R Shiraki, K Otsui, T Honjo, M Takahashi, T Shinke, J Shite, K Hirata, S Kawashima, M Yokoyama, H Yokozaki, T Mori, Y Ohashi, S Ichikawa, M Terashima, K Awano
    Apr. 2006, CIRCULATION, 113(16) (16), E724 - E725, English
    Report scientific journal

■ Books And Other Publications
  • 今日の治療指針 2019年版 / 6.循環器疾患 無症候性心筋虚血
    Kobayashi Seimi
    Others, 医学書院, Jan. 2019, Japanese
    General book

  • 今日の治療指針 2018年版 / ６．循環器疾患 「心臓神経症 Cardiac Neurosis」
    Kobayashi Seimi
    Others, 医学書院, Jan. 2018, Japanese
    General book

  • 5. 日本臨牀2016年6月増刊号 最新冠動脈疾患学（上）－冠動脈疾患の最新治療戦略－ / 総論 ３．冠動脈疾患の発症予測と早期治療介入の現状と課題
    Kobayashi Seimi, 平田健一
    Others, 日本臨牀社, Jun. 2016, Japanese
    Scholarly book

  • 心臓リハビリテーション / 肺高血圧症治療における心臓リハビリテーションと運動耐容能評価 診断時から回復期にわたる長期介入への提言
    坪井康典, 田中秀和, Kobayashi Seimi, 佐和琢磨, 寺下大輔, 絹谷洋人, 中山和彦, 井澤和大, 酒井良忠, 江本憲昭, 平田健一
    Others, 日本心臓リハビリテーション学会, Apr. 2016, Japanese
    Scholarly book

  • 今日の治療指針 私はこう治療している 2015 / 高安動脈炎（大動脈症候群、脈なし病）
    Kobayashi Seimi
    Others, 医学書院, 2015, Japanese
    General book

  • 心不全診療Q&A エキスパート106人からの回答 / II.心不全診療Q&A ５．慢性心不全の薬物療法 (8)β遮断薬を入れるタイミングはどのように考えたらよいですか？ (9)β遮断薬を増量する目安には何を用いればよいでしょうか？ (10)β遮断薬はどれくらいまで増量すべきでしょうか？
    Kobayashi Seimi, Hirata Kenichi
    Others, 中外医学社, Sep. 2012, Japanese
    General book

  • 循環器疾患最新の治療2012-2013 / XVI その他、4 Raynaud 現象
    Kobayashi Seimi
    Others, 南江堂, Mar. 2012, Japanese
    Scholarly book

  • 1. 日本臨牀65巻増刊号4 心不全（上）－最新の基礎・臨床研究の進歩－ / IV．成因病態に関する基礎的研究、3．サイトカインによる心筋細胞肥大・線維化・炎症惹起の機序、1）TN-α
    Kobayashi Seimi, 川嶋成乃亮
    Others, 日本臨牀社, 2007, Japanese
    Scholarly book

■ Lectures, oral presentations, etc.
  • Novel Deep Venous Thrombosis Model Enabled Visualization of Thrombus Formation and Organization Process in vivo.
    Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata
    第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Method: We established a novel murine DVT model, suitable for real-time in vivo imaging. Thr, Domestic conference
    Oral presentation

  • Evaluation of Microvasculopathy using Dual-Energy CT in Chronic Thromboembolic Pulmonary Hypertension
    Hiroyuki Onishi, Yu Taniguchi, Yoichiro Matsuoka, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yasunori Tuboi, Shumpei Mori, Kazuhiko Nakayama, Hiromasa Otake, Seimi Satomi-Kobayashi, EMOTO NORIAKI, Kenichi Hirata
    第83回日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Domestic conference
    Poster presentation

  • Comparison of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, and Cholesterol Efflux Capacity in Association with Coronary Plaque Properties
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata
    第83回 日本循環器学会学術集会, Mar. 2019, English, 日本循環器学会, 横浜, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the procedures require cultured cells and are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol uptake capacity (, Domestic conference
    Poster presentation

  • 心臓リハビリテーション多職種協働介入による再入院予防効果の検証
    石井 裕輝, 宇賀慶子, 髙濱和美, 小槇公大, 小川真人, 坪井康典, 西田ひかる, 脇田久美子, GOTAKE YASUKO, Satomi-Kobayashi Seimi, HIRATA KENICHI
    第4回日本心臓リハビリテーション学会近畿地方会, Feb. 2019, Japanese, 京都, Domestic conference
    Oral presentation

  • K君の物語
    MATSUMOTO KENSUKE, Satomi-Kobayashi Seimi, HIRATA KENICHI
    第4回日本心臓リハビリテーション学会近畿地方会, Feb. 2019, Japanese, 日本心臓リハビリテーション学会, 京都, 神戸大学で経験した心臓病緩和の物語。, Domestic conference
    [Invited]
    Nominated symposium

  • Comparison of Clinical Utility Between Cholesterol Uptake Capacity, a Novel Indicator of HDL Functionality, and Cholesterol Efflux Capacity
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Ken-ichi Hirata
    第35回 国際心臓研究学会日本部会, Dec. 2018, English, 国際心臓研究学会日本部会, 東京, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, Domestic conference
    Poster presentation

  • 新規マウス血栓モデルによるDVT生体イメージング
    岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI
    第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景: 担癌患者では血栓形成傾向による静脈血栓症の合併が多いが、深部静脈血栓症(DVT)の詳細な機序は未だに不明である。血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンを伴う赤色血栓であり、ヒトDVTに病態生理学的に類似する。また好発部位である静脈弁に血栓が形成されやすく、血栓溶解や血栓塞栓子遊離の観察も可能である。血栓形成時には赤血球凝集が先行し、既存の, Domestic conference
    Oral presentation

  • 高比重リポタンパクによる酸化ストレスに対する心保護作用は PI3K/mTOR シグナリング経路を介する
    渡部晃一, TOH RYUJI, 西森誠, 岡野光真, 尾下寿彦, 林友鴻, 長尾学, IRINO YASUHIRO, HARA TETSUYA, SHINOHARA MASAKAZU, Satomi-Kobayashi Seimi, ISHIDA TATSURO, HIRATA KENICHI
    第1回 日本腫瘍循環器学会, Nov. 2018, Japanese, 日本腫瘍循環器学会, 東京, 背景：高比重リポタンパク (High-density lipoprotein；HDL) は心血管系に対して多面的な効果を有することが知られている。HDLがドキソルビシンによる活性酸素種の生成を介した心筋障害から細胞保護効果を示すことが報告されているが、心筋細胞に対して及ぼす直接的な影響は十分に明らかにされていない。目的：HDLが酸化ストレス下において心筋細胞へ及ぼす効果を検証する。方法と結果：H9C2細胞に対して、HDLによる前処理を加えた後にH2O2 による酸化ストレス刺激を加えると、HDLの容量依存性に細胞保護効果を示すことを明らかにした。HDLによる処理は、H9C2細胞のAktのリン酸化を有意に増加させ、一方PI3K阻害剤であるLY294002、mTOR阻害剤であるラパマイシンを投与することにより、Aktのリン酸化ならびにHDLの有する抗アポト, Domestic conference
    Oral presentation

  • Reduction of 5-Lipoxygenase Derived Docosahexaenoic Acid Metabolites Under Social Mental Stress: Their Function for Maintenance of Heme Oxygenase-1 Expression in Macrophage
    Makoto Nishimori, Masakazu Shinohara, Kouichi Watanabe, Mitsumasa Okano, Toshihiko Oshita, Kenta Mori, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata
    American Heart Association's 2018 Scientific Sessions, Nov. 2018, English, シカゴ, Epidemiological studies reveal an association between social mental stresses and incidence of cardiovascular disease. Although hyperactivation of sympathetic nerve system is reported to induce systemic inflammation, little is known regarding precise mechanisms how social mental stress induces systemic inflammation and cardiovascular events. We have developed liquid chromatograp, International conference
    Poster presentation

  • Establishment of Novel Deep Venous Thrombosis Model Suitable for in vivo Imaging
    Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata
    American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Backgrounds: The pathogenesis of DVT (deep venous thrombosis) is still unclear, largely due to a lack of an appropriate animal model. Although stasis is a major cause of DVT formation, IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the ro, International conference
    Oral presentation

  • Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality, Versus Cholesterol Efflux Capacity in Association with Coronary Plaque Lipid Burden
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Koichi Watanabe, Yuichiro Nagano, Amane Harada, Katsuhiro Murakami, Satomi-Kobayashi Seimi, Masakazu Shinohara, Tetsuya Hara, Yasuhiro Irino, Hiromasa Otake, Tatsuro Ishida, Kenichi Hirata
    American Heart Association Scientific Sessions 2018., Nov. 2018, English, American Heart Association, シカゴ, Background: Cholesterol efflux capacity (CEC) measurement is not instantly applicable in clinical settings, because the methods require cultured cells, and the procedures are time consuming. Recently, we established a simple, high-throughout, cell-free assay system to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as “cholesterol upta, International conference
    Poster presentation

  • Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Kazuhiko Nakayama, Kenichi Yanaka, Noaki Tamada, Yu Izawa, Yuto Shinkura, Syunsuke Shimoyama, Tatsuya Nishii, Atsushi Kono, Shumpei Mori, Hiromasa Otake, Seimi Satomi-Kobayashi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata
    ESC Congress 2018, Aug. 2018, English, European Sciety of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Lung perfusion recovery evaluated by dual-energy CT correlated with the improvement of exercise capacity in chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Kazuhiko Nakayama, Ken-ichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Hiromasa Otake, Satomi-Kobayashi Seimi, Toshiro Shinke, Noriaki Emoto, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), Aug. 2018, English, European Society of Cardiology, ミュンヘン, International conference
    Poster presentation

  • Searching for modulating factor of cholesterol uptake capacity, a novel indicator for HDL functionality
    Toshihiko Oshita, Ryuji Toh, Mitsumasa Okano, Shigeyasu Tsuda, Koichi Watanabe, Satomi-Kobayashi Seimi, Tetsuya Hara, Masakazu Shinohara, Yasuhiro Irino, Katsuhiro Murakami, Amane Harada, Tatsuro Ishida, Kenichi Hirata
    第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC). CUC could be an indicator of HDL function for coronary risk stratification. In this study, we sought to identify modulating factors of CUC. Methods: We used nu, Domestic conference
    Poster presentation

  • Real-Time in Vivo Imaging of Thrombosis Initiated by Red Blood Cell Aggregation in Novel Murine Stasis Model of DVT
    Mitsumasa Okano, Tetsuya Hara, Makoto Nishimori, Koichi Watanabe, Toshihiko Oshita, Shigeyasu Tsuda, Kenta Mori, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata
    第50回 日本動脈硬化学会総会・学術集会, Jul. 2018, Japanese, 日本動脈硬化学会, 大阪, Background: Stasis is a major cause of DVT (deep venous thrombosis) formation. IVC (inferior vena cava) stasis model is not suitable for in vivo imaging because of its deep location. Real-time imaging in other thrombosis models including FeCl3 and laser injury showed the roles of platelets and leukocytes in the initiation of DVT, but they are mainly caused by endothelial injury, Domestic conference
    Poster presentation

  • Novel murine deep venous thrombosis (DVT) model enables real-time in vivo imaging of clinically relevant DVT.
    Mitsumasa Okano, Tetsuya Hara, Yasuhiro Irino, Satomi-Kobayashi Seimi, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Kenichi Hirata
    International Academy of Cardiology Annual Scientific Sessions 2018 23rd World Congress on Heart Disease, Jul. 2018, English, International Academy of Cardiology, ボストン, Background: The pathogenesis of deep venous thrombosis (DVT) is still unclear, largely due to a lack of an adequate animal model. Although stasis is a major cause of DVT formation, inferior vena cava stasis model is not suitable for in vivo imaging because of its deep location. Other thrombosis models allowing in vivo imaging such as FeCl3 and laser injury induce platelet throm, International conference
    Oral presentation

  • Impact of Delirium on Postoperative Frailty and Cardiovascular Events after Cardiac Surgery.
    Masato Ogawa, Kazuhiro P Izawa, Seimi-Satomi Kobayashi, Yasunori Tsuboi, Kodai Komaki, Yasuko Gotake, Hiroshi Tanaka, Kenichi Hirata, Yoshitada Sakai, Yutaka Okita
    第24回日本心臓リハビリテーション学会学術集会, Jul. 2018, English, 日本心臓リハビリテーション学会, 横浜, Domestic conference
    Oral presentation

  • 不整脈および左室収縮機能障害を合併した、抗ミトコンドリアM2抗体陽性筋炎の1例
    竹本 良, MATSUMOTO KENSUKE, 柴田 奈緒, 黒田 浩史, Satomi-Kobayashi Seimi, TANAKA HIDEKAZU, HIRATA KENICHI, SEKIGUCHI KENJI, Quan Yang
    第126回 日本循環器学会近畿地方会, Jun. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 新規マウス血栓モデルによる赤血球凝集主体のDVT生体イメージング
    岡野 光真, HARA TETSUYA, 西森 誠, 渡部 晃一, 尾下 寿彦, 津田 成康, IRINO YASUHIRO, Satomi-Kobayashi Seimi, SHINOHARA MASAKAZU, TOH RYUJI, ISHIDA TATSURO, HIRATA KENICHI
    第55回 日本臨床分子医学会学術集会, Apr. 2018, Japanese, 日本臨床分子医学会, 京都, 背景: 血流鬱滞はDVT形成要因の一つであるが、既存の下大静脈結紮モデルは時間・空間解像度の観点から生体イメージングには適さない。リアルタイムイメージングに用いられる既存の血栓モデルは内皮傷害による血小板血栓であり、DVT形成機序の理解には新たな静脈血栓モデルが求められる。方法: 大腿静脈結紮による血流鬱滞と蛍光顕微鏡観察による励起光照射で、リアルタイムに形成されるマウスDVTモデルを確立した。結果: 本モデルの血栓は、血管長軸方向に伸展する形態かつフィブリンネットワークを伴う赤色血栓であり、ヒトDVTに病理生態学的に類似する。また好発部位である静脈弁や血管合流部など血流鬱滞部が起始部になりやすい。血栓形成時には赤血球凝集が先行し、内皮傷害血栓モデルに見られる血小板や白血球は目立たず、フィブリンとともに遅れて集積して器質化する。器質化の程度によって、, Domestic conference
    Poster presentation

  • Treatment goal of BPA would be extensive perfusion recovery beyond hemodynamic normalization
    Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第82回 日本循環器学会学術集会, Mar. 2018, English, 日本循環器学会, 大阪, Domestic conference
    Poster presentation

  • In Vivo Imaging Revealed Platelet- and Leukocyte- independent Initiation of Deep Venous Thrombosis (DVT) in Novel Murine DVT Model
    Mitsumasa Okano, Hara Tetsuya, Toshihiko Oshita, Shigeyasu Tsuda, Koichi Watanabe, Kobayashi Seimi, Irino Yasuhiro, Shinohara Masakazu, Toh Ryuji, Ishida Tatsuro, Hirata Ken-ichi
    The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Although past reports showed the role of platelets and leukocytes in the initiation of DVT, the underlying mechanism is not fully understood.Method: We established a novel DVT model, suitable for in vivo imaging; DVT can be formed and visualiz, Domestic conference
    Poster presentation

  • Identification of Determinants of Cholesterol Uptake Capacity, a Novel Indicator for HDL Functionality
    Toshihiko Oshita, Toh Ryuji, Mitsumasa Okano, Shigeyasu Tsuda, Ko-ichi Watanabe, Kobayashi Seimi, Hara Tetsuya, Shinohara Masakazu, Irino Yasuhiro, Katsuhiro Murakami, Amane Harada, Ishida Tatsuro, Hirata Ken-ichi
    The 82th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2018, English, Japanese Circulation Society, 大阪, Background: Recently, we established a simple, high-throughput, cell-free assay system to evaluate the capacity of high-density lipoprotein (HDL) to accept additional cholesterol, named cholesterol uptake capacity (CUC), and demonstrated its feasibility f, Domestic conference
    Poster presentation

  • 反復性肺炎に伴う肺高血圧症患者の人工呼吸器離脱に対して心リハが有効であった一例
    坪井 康典, Kobayashi Seimi, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi
    第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Oral presentation

  • 神戸大学における循環器医療連携の試み
    Kobayashi Seimi, Hirata Ken-ichi
    第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Oral presentation

  • 心血管外科手術周術期の口腔機能管理に関する臨床的検討
    難波渚, Akashi Masaya, Komori Takahide, 桶本翔吾, 小槇 公大, 小川 真人, 坪井 康典, Kobayashi Seimi, Gotake Yasuko, Okita Yutaka
    第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Oral presentation

  • 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討
    内田 絢子, 脇田 久美子, 小槙 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, 宇佐美 眞
    第21回病態栄養学会年次学術集会, Feb. 2018, Japanese, 日本病態栄養学会, 京都, Domestic conference
    Oral presentation

  • 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討
    脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 赤毛 弘子, 大瀬良 知子, 栗原 伸公
    第3回 日本心臓リハビリテーション学会 近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Poster presentation

  • 高塩分食品・調味料等の使用習慣に基づいた食塩摂取量簡易評価方法の検討
    脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 山下 弘子, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Toh Ryuji, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公
    第3回日本心臓リハビリ―ション学会近畿支部地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Poster presentation

  • サルコペニアを有する心不全患者における身体活動量と健康関連QOLの特性
    小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, 吉田 尚史, Sakai Yoshitada, Hirata Ken-ichi
    第3回日本心臓リハビリテーション学会近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Oral presentation

  • TAVI患者におけるFrailtyが術後リハビリテーションに及ぼす影響
    小槇公大, Kobayashi Seimi, 井澤和大, 坪井康典, 小川真人, Gotake Yasuko, 吉田尚史, Sakai Yoshitada, Shinke Toshiro, Hirata Ken-ichi
    第3回 日本心臓リハビリテーション学会 近畿地方会, Feb. 2018, Japanese, 日本心臓リハビリテーション学会, 神戸, Domestic conference
    Oral presentation

  • Sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Nakayama Kazuhiko, Shinke Toshiro, Otake Hiromasa, Hiroyuki Kawamori, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yasunori Tsuboi, Kobayashi Seimi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • Pulmonary Blood Volume by Dual-energy CT is a new management index for chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Nakayama Kazuhiko, Kenichi Yanaka, Naoki Tamada, Yu Izawa, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • Predictors for worsening hemodynamics during follow-up period after balloon pulmonary angioplasty
    Yuto Shinkura, Nakayama Kazuhiko, Hiroyuki Ohnishi, Kenichi Yanaka, Naoki Tamada, Yasunori Tsuboi, Kobayashi Seimi, Otake Hiromasa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    6th World Symposium on Pulmonary Hypertension, Feb. 2018, English, 6th World Symposium on Pulmonary Hypertension working group, ニース, フランス, International conference
    Poster presentation

  • 高血圧患者における高塩分食品・調味料の使用習慣に基づいた塩分摂取量簡易評価方法の検討
    脇田 久美子, 三ヶ尻 礼子, 田渕 聡子, 山西 美沙, 赤毛 弘子, 玉田 萌子, 西田 ひかる, 中谷 早希, 金谷 沙紀, 森 智子, 向山 万為子, 中村 美仁, 山本 育子, Matsuda Yoshiko, Takahashi Michiko, Ogawa Wataru, Kobayashi Seimi, Ishida Tatsuro, 大瀬良 知子, 栗原 伸公
    第21回病態栄養学会年次学術集会, Jan. 2018, Japanese, 日本病態栄養学会, 京都, Domestic conference
    Oral presentation

  • Pulmonary blood volume evaluated by dual-energy CT is a new maker for the management of chronic thromboembolic pulmonary hypertension
    Hiroyuki Onishi, Nakayama Kazuhiko, Ken-ichi Yanaka, Naoki Tamada, Yuto Shinkura, Yasunori Tuboi, Shinsuke Shimoyama, Tatsuya Nishii, Atushi Kono, Noriyuki Negi, Shumpei Mori, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    American Heart Association Scientific Sessions 2017, Nov. 2017, English, American Heart Association, アナハイム, USA, International conference
    Poster presentation

  • PEA周術期におけるCTEPH患者に対する心臓リハビリテーション―術前運動耐容能評価が有用であった1例―
    坪井 康典, Kobayashi Seimi, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Tanaka Hiroshi, Okita Yutaka, Hirata Ken-ichi
    第126回日本循環器学会近畿地方会, Nov. 2017, Japanese, 日本循環器学会, 大阪, Domestic conference
    Oral presentation

  • 肺高血圧症患者における唾液アミラーゼ亢進は運動耐容能低下を反映する
    坪井康典, SATOMI-KOBAYASHI SEIMI, 寺下大輔, 玉田直己, 小川真人, 小槇公大, NAKAYAMA KAZUHIKO, TANAKA HIDEKAZU, IZAWA P. KAZUHIRO, SAKAI YOSHITADA, EMOTO NORIAKI, HIRATA KENICHI
    第23回日本心臓リハビリテーション学会学術集会, Jul. 2017, Japanese, Domestic conference
    Oral presentation

  • 大動脈弁狭窄症患者における基本チェックリストと従のフレイル評価および術後運動耐容能との関連
    小槇公大, 井澤和大, Kobayashi Seimi, Gotake Yasuko, 坪井康典, 小川真人, 寺下大輔, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka
    第23回日本心臓リハビリテーション学会 学術集会, Jul. 2017, Japanese, 日本心臓リハビリテーション学会, 岐阜, Domestic conference
    Poster presentation

  • 術前サルコペニアは心臓術後合併症を予測する～CTによる筋量と身体機能を用いた検討～
    小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, Sakai Yoshitada, Hirata Ken-ichi, Tanaka Hiroshi, Okita Yutaka
    第23回日本心臓リハビリテーション学会学術集会, Jul. 2017, Japanese, 日本心臓リハビリテーション学会, 岐阜, Domestic conference
    Public symposium

  • CTEPHに対するハイブリッド治療の有効性・安全性について
    谷仲 謙一, Nakayama Kazuhiko, 玉田 直己, 大西 裕之, 新倉 悠人, 坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, Shinke Toshiro, EMOTO NORIAKI, Hirata Ken-ichi
    第2回日本肺高血圧・肺循環学会学術集会, Jun. 2017, Japanese, 日本肺高血圧・肺循環学会, 札幌, Domestic conference
    Oral presentation

  • Safety of Complete Revascularization of Balloon Pulmonary Angioplasty on Chronic Thromboembolic Pulmonary Hypertension beyond Normalized Mean Pulmonary Arterial Pressure
    Yuto Shinkura, Nakayama Kazuhiko, Kenichi Yanaka, Yoshiro Tsukiyama, Hiroyuki Yamamoto, Yuichiro Nagano, Naoki Tamada, Yoshinori Nagasawa, Natsuko Tahara, Kenzo Uzu, Koji Kuroda, Yasunori Tsuboi, Daisuke Terashita, Hachidai Takahashi, Takayoshi Toba, Tanaka Hidekazu, Otake Hiromasa, Kobayashi Seimi, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第81回 日本循環器学会学術集会, Mar. 2017, English, 日本循環器学会, 金沢, Domestic conference
    Poster presentation

  • 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討
    内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto
    第32回日本静脈経腸栄養会年次学術集会, Feb. 2017, Japanese, 日本静脈経腸栄養学会, 岡山, Domestic conference
    Poster presentation

  • 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討
    内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto
    The 32nd Annual Meeting of Japanese Society for Parenteral and Enteral Nutrition, Feb. 2017, Japanese, 日本静脈経腸栄養学会, 岡山, Domestic conference
    Poster presentation

  • 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討
    内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru, Usami Makoto
    第20回日本病態栄養学会, Jan. 2017, Japanese, 日本病態栄養学会, 京都, Domestic conference
    Oral presentation

  • 高齢大動脈弁狭窄症患者における術後食事摂取量への影響の検討
    内田 絢子, 脇田 久美子, 小槇 公大, 小川 真人, 坪井 康典, 山西 美沙, 田渕 聡子, 三ヶ尻 礼子, 寺下 大輔, Gotake Yasuko, Kobayashi Seimi, 山本 育子, Yamamoto Masashi, Takahashi Michiko, Ogawa Wataru
    第20回日本病態栄養学会年次学術集会, Jan. 2017, Japanese, 日本病態栄養学会, 京都, Domestic conference
    Oral presentation

  • Compensatory Accumulation of Myocardial β-Hydroxybutyrate Accompanied by SCOT Downregulation in Response to Oxidative Stress
    Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi
    ISHR 2016, Dec. 2016, Japanese, International Society for Heart Research, 東京, Recent studies have shown that the ketone body -hydroxybutyrate (βOHB) acts not only as a carrier of energy but also as a signaling molecule that has a role in diverse cellular functions. Circulating βOHB levels have been previously reported to be increa, Domestic conference
    Oral presentation

  • Compensatory Accumulation of βHydroxybutyrate Accompanied by SCOT Downregulation in Failing Hearts
    Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Hara Tetsuya, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Tanaka Hidekazu, Ishida Tatsuro, Hirata Ken-ichi
    American Heart Association Scientific sessions 2016, Nov. 2016, English, American Heart Association, New Orleans, USA, Background and ObjectiveCirculating levels of ketone bodies have been previously reported to be increased in patients with congestive heart failure (HF). Recent studies have shown that the ketone body β-hydroxybutyrate (βOHB) acts not only as a carrier of, International conference
    Poster presentation

  • 圧正常化CTEPH患者に対する追加BPA効果の検討
    新倉 悠人, Nakayama Kazuhiko, 谷仲 謙一, 玉田 直己, 坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, Shinke Toshiro, 江本 憲昭, Hirata Ken-ichi
    Japanese Pulmonary Hypertension Society(JPHS)・Japanese Pulmonary Circulation Society(JPCS), Oct. 2016, Japanese, Japanese Pulmonary Hypertension Societ,Japanese Pulmonary Circulation Societ, 東京, Domestic conference
    Oral presentation

  • Impact of Delirium on Postoperative Frailty and Long Term Cardiovascular Events after Cardiac Surgery
    Masato Ogawa, Kazuhiro Izawa, Kobayashi Seimi, Yasunori Tsuboi, Kodai Komaki, Gotake Yasuko, Tanaka Hiroshi, Hirata Ken-ichi, Sakai Yoshitada, Okita Yutaka
    The 20th Annual Scientific Meeting of the Japanese Heart Filure Society, Oct. 2016, Japanese, 日本心不全学会, 札幌, Domestic conference
    Oral presentation

  • 心肺運動負荷試験結果に基づく運動療法は肺高血圧症患者の気分状態を即時的に改善させる
    坪井 康典, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 小川 真人, 小槇 公大, Nakayama Kazuhiko, Tanaka Hidekazu, 井澤 和大, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi
    The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, Japanese, 日本心臓リハビリテーション学会, 東京, Domestic conference
    Oral presentation

  • 高度大動脈弁狭窄症患者における術後リハビリテーション進行に関わる要因についての検討
    小槇公大, 井澤和大, Kobayashi Seimi, Gotake Yasuko, 小川真人, 坪井康典, 佐和琢磨, 寺下大輔, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka
    The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, Japanese, 日本心臓リハビリテーション学会, 東京, Domestic conference
    Oral presentation

  • Gait Speed Is a Predictor of Postoperative Delirium in Elderly Cardiac Surgery Patients
    小川 真人, 井澤 和大, Kobayashi Seimi, Gotake Yasuko, 坪井 康典, 小槇 公大, Sakai Yoshitada, 佐和 琢磨, Hirata Ken-ichi, Okita Yutaka
    The 22nd Annual Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2016, English, 日本心臓リハビリテーション学会, 東京, Domestic conference
    Oral presentation

  • 待機的心臓手術患者において術前身体活動は術後せん妄を予測する
    小川 真人, 井澤 和大, 北村 アキ, Kobayashi Seimi, 小槇 公大, Ono Rei, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka
    The 51st Congress of Japanese Society of Physical Therapy, May 2016, Japanese, 日本理学療法士協会, 札幌, Domestic conference
    Oral presentation

  • 肺動脈性肺高血圧症および慢性血栓塞栓性肺高血圧症患者に対する運動耐容能および血行動態評価として心肺運動負荷試験は有用である
    坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi
    The 80th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2016, Japanese, The Japanese Circulation Society, 仙台, Domestic conference
    Poster presentation

  • 高齢開心術患者の術前6分間歩行距離は術後の自宅退院を予測する
    小槇 公大, Kitamura Aki, 小川 真人, 坪井 康典, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 井澤 和大, Sakai Yoshitada, Hirata Ken-ichi, Okita Yutaka
    The 80th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2016, Japanese, The Japanese Circulation Society, 仙台, Domestic conference
    Oral presentation

  • Examination of the correlation between Health Related Quality of Life scores and parameters from six-minute walk test in pulmonary hypertension
    Naoki Tamada, Nakayama Kazuhiko, Ken-ichi Yanaka, Yuto Shinkura, Yasunori Tuboi, Tanaka Hidekazu, Kobayashi Seimi, Kazuhiro Izawa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第80回日本循環器学会総会, Mar. 2016, English, 日本循環器学会, 仙台, Domestic conference
    Oral presentation

  • Characterization of the patients with sustained low oxygen saturation at one year after balloon pulmonary angioplasty.
    Nakayama Kazuhiko, Yuto Shinkura, Naoki Tamada, Ken-ichi Yanaka, Yasunori Tuboi, Tanaka Hidekazu, Kobayashi Seimi, Kazuhiro Izawa, Shinke Toshiro, Noriaki Emoto, Hirata Ken-ichi
    第80回日本循環器学会総会, Mar. 2016, English, 日本循環器学会, 仙台, Domestic conference
    Oral presentation

  • 肺動脈内膜摘除術周術期における慢性血栓塞栓性肺高血圧症患者の身体機能について
    坪井 康典, Kobayashi Seimi, Kitamura Aki, 小川 真人, 小槇 公大, 佐和 琢磨, 寺下 大輔, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi, Okita Yutaka
    日本心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, The Japanese Association of Cardiac Rehabilitation, 京都, Domestic conference
    Oral presentation

  • 心臓リハビリテーションにおける管理栄養士の役割と今後の課題
    内田 絢子, 脇田 久美子, 戸田 明代, 坪井 康典, 小川 真人, 小槇 公大, Takahashi Michiko, Usami Makoto, 佐和 琢磨, 寺下 大輔, Kitamura Aki, Kobayashi Seimi
    心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, 京都, Domestic conference
    Oral presentation

  • 心臓リハビリテーションにおける管理栄養士の役割と今後の課題
    内田 絢子, 脇田 久美子, 戸田 明代, 坪井 康典, 小川 真人, 小槇 公大, Takahashi Michiko, Usami Makoto, 佐和 琢磨, 寺下 大輔, Kitamura Aki, Kobayashi Seimi
    日本心臓リハビリテーション学会第1回近畿地方会, Feb. 2016, Japanese, The Japanese Association of Cardiac Rehabilitation, 京都, Domestic conference
    Poster presentation

  • 血管平滑筋細胞における高グルコース誘導性のアルカリフォスファターゼ（ALP）遺伝子発現増加およびALP活性亢進へのRho-ROCK経路およびBMPERの関与
    寺尾 侑也, Kobayashi Seimi, Hirata Ken-ichi, Rikitake Yoshiyuki
    The 23rd Annual Scientific Meeting of the Japanese Vascular Biology and Medicine Organization, Dec. 2015, Japanese, The Japanese Vascular Biology and Medicine Organization, 神戸, Domestic conference
    Poster presentation

  • Cardio pulmonary Exercise Testing is Valuable for Assessing Exercise Capacity and Hemodynamic Status in Patients with Chronic Thromboembolic Pulmonary Hypertension
    坪井 康典, Kobayashi Seimi, Tanaka Hidekazu, 寺下 大輔, 佐和 琢磨, 新倉 悠人, Nakayama Kazuhiko, 江本 憲昭, Hirata Ken-ichi
    The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, Domestic conference
    Oral presentation

  • Safety of Cardiopulmonary Exercise Testing for Assessing Preoperative Exercise Capacity in Japanese Patients with Asymtomatic Aortic Stenosis
    小槇 公大, Kobayashi Seimi, 坪井 康典, 小川 真人, 井澤 和大, 佐和 琢磨, Kitamura Aki, Okita Yutaka, Hirata Ken-ichi
    The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, Domestic conference
    Oral presentation

  • Poor exercise capacity is associated with the prevalence of postoperative delirium in elective cardiac surgery.
    小川 真人, 井澤和大, Kitamura Aki, Kobayashi Seimi, 坪井 康典, 小槇 公大, 寺下 大輔, 佐和 琢磨, Hirata Ken-ichi
    The 19th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2015, Japanese, The Japanese Heart Failure Society, 大阪, 【Background】Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial, but has not been fully explored. The, Domestic conference
    Oral presentation

  • 肺高血圧症治療における心臓リハビリテーションと運動耐容能評価―診断時から回復期に渡る長期介入の提言―
    坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 絹谷 洋人, Nakayama Kazuhiko, 井澤 和大, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi
    The 21th Annual Scientific Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2015, Japanese, The Japanese Association of Cardiac Rehabilitation, 福岡, 【背景】当施設では新規肺高血圧症(PH)患者に対し、内科的、外科的治療を行う前の診断時から心臓リハビリテーション(心リハ)を行っている。【方法】2010年6月から2014年12月までに、診断時から心肺運動負荷試験を用い運動耐容能評価を行ったPH患者41例（年齢57±16歳、女性28例、治療前平均肺動脈圧：37.8±12.8mmHg、心係数：2.4±0.8 l/min/m2）を対象に治療前後の運動耐容能の変化を検討した(観察期間：293±261日)。【結果】治療後、運動耐容能は有意に改善したが、依然として低値であった（%予測最高酸素摂取量：46.8±11.8％ vs. 58.6±14.0％ p<0.0001, VE/VCO2 slope 45.1±13.9 vs. 36.6±12.5 p<0.0001）。対象患者のうち、心不全による再入院が5/41例、, Domestic conference
    Public symposium

  • 左心補助人工心臓（LVAS）から離脱した症例における運動能力と社会心理的指標の推移
    小川 真人, Kobayashi Seimi, 坪井 康典, 小槇 公大, 井澤 和大, 寺下 大輔, 佐和 琢磨, Tanaka Hidekazu, Sakai Yoshitada, Hirata Ken-ichi
    The 21th Annual Scientific Meeting of the Japanese Association of Cardiac Rehabilitation, Jul. 2015, Japanese, The Japanese Association of Cardiac Rehabilitation, 福岡, Domestic conference
    Poster presentation

  • 2-Aminobutyric acid reflects myocardial redox state in doxorubicin-induced cardiomyopathy
    Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi
    11th International Conference of the Metabolomics Society (Metabolomics 2015), Jun. 2015, English, Metaboomics Society, San Francisco, USA, Introduction:Clinical usage of doxorubicin (DOX) as a chemotherapeutic drug is limited by cumulative dose-related cardiotoxicity caused by oxidative stress. Empiric dose limitation is insufficient to prevent DOX-induced cardiotoxicity due to a great varia, International conference
    Poster presentation

  • 心臓血管外科手術前の低栄養状態と術後リハビリテーション進行遅延の関係について
    小川 真人, Inoue Takeshi, 坪井 康典, 小槇 公大, 井澤 和大, Kobayashi Seimi, Sakai Yoshitada, Ono Rei, Hirata Ken-ichi, Okita Yutaka
    The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, Japanese, The Japanese Circulation Society, 大阪, Domestic conference
    Poster presentation

  • バルーン肺動脈形成術による慢性血栓塞栓性肺高血圧症患者の最高酸素摂取量改善に関与する術前因子および治療前後変化の検討
    坪井 康典, Tanaka Hidekazu, Kobayashi Seimi, 佐和 琢磨, 寺下 大輔, 絹谷 洋人, Nakayama Kazuhiko, Sakai Yoshitada, 江本 憲昭, Hirata Ken-ichi
    The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, Japanese, The Japanese Circulation Society, 大阪, 【背景】 慢性血栓塞栓性肺高血圧症(CTEPH)に対する治療目標として心肺運動負荷試験(CPX)指標の1つである最高酸素摂取量(Peak VO2)が用いられているが、バルーン肺動脈形成術(BPA)によるCTEPH患者のPeak VO2改善に関与する術前因子および治療前後変化に関する検討を認めない。【方法】2011年5月から2014年10月までに当院循環器内科にてBPAおよび治療前後評価としてCPXが施行されたCTEPH患者連続20例(年齢63±12歳、女性14例)を対象とし、後ろ向き解析を行った。BPA前後のPeak VO2改善(Δ Peak VO2)の中央値であった2.4ml/kg/minをカットオフ値とし、Responder群(RG、11例とNon-responder群(NRG、9例)の2群に分類し、術前因子および治療前後変化に関する比較検討を行, Domestic conference
    Poster presentation

  • Feasibility of 2-Aminobutyric acid as a biomarker for early detection of doxorubicin-induced cardiotoxicity
    Manabu Nagao, Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Tomoyuki Honjo, Kobayashi Seimi, Shinohara Masakazu, Shinke Toshiro, Ishida Tatsuro, Hirata Ken-ichi
    The 79th Annual Scientific Meeting of the Japanese Circulation Society, Apr. 2015, English, Japanese Circulation Society, 大阪, Background:Empiric dose limitation is insufficient to prevent doxorubicin (DOX)-induced cardiotoxicity due to a great variability in individual DOX tolerance. Recently, we revealed that 2-aminobutyric acid (2-AB) was produced as a byproduct of glutathione, Domestic conference
    Oral presentation

  • Circulating levels of 2-Aminobutyric acid reflect myocardial redox state in patients with atrial septal defects
    Irino Yasuhiro, Toh Ryuji, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi
    American Heart Association Scientific Sessions 2014, Nov. 2014, English, American Heart Association, シカゴ, アメリカ, Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectromet, International conference
    Poster presentation

  • 2-Aminobutyric acid, a potential indicator of oxidative stress in failing hearts
    Toh Ryuji, Irino Yasuhiro, Takeshige Mori, Manabu Nagao, Tomoyuki Honjo, Kobayashi Seimi, Ishida Tatsuro, Okiko Miyata, Hirata Ken-ichi
    The 18th Annual Scientific Meeting of the Japanese Heart Failure Society, Oct. 2014, Japanese, The Japanese Heart Failure Society, 大阪, Early diagnosis of heart failure (HF) remains difficult and identification of more sensitive biomarkers than conventional ones is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patie, Domestic conference
    Oral presentation

  • Exploration of biomarkers for the detection of heart failure
    Irino Yasuhiro, Toh Ryuji, 森 健茂, 長尾 学, 本庄 友行, Kobayashi Seimi, Shinke Toshiro, Ishida Tatsuro, 宮田 興子, Hirata Ken-ichi
    The 39th Annual Meeting of the Japanese Soxiety for Biomedical Mass Spectrometry, Oct. 2014, Japanese, The Japanese Soxiety for Biomedical Mass Spectrometry, 千葉, (Background) Heart failure (HF) is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task.(Methods) We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromat, Domestic conference
    Poster presentation

  • Expression and pro-inflammatory functions of FAM5C, a genetic risk factor for acute mayocardial infarction, in vascular endothelial cells
    Mitsuo Kinugasa, Rikitake Yoshiyuki, Kobayashi Seimi, Kinta Hatakeyama, Shota Yamana, Fumie Kureha, Junya Satoh, Yujiro Asada, Hirata Ken-ichi
    78th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2014, English, the Japanese Circulation Society, 東京, Domestic conference
    Poster presentation

  • ERK Acts Downstream of Nectin-like Molecule-5 in Phenotypic Reversion of Vascular Smooth Muscle Cells
    Fumie Kureha, Kobayashi Seimi, Mitsuo Kinugasa, Hirata Ken-ichi, Rikitake Yoshiyuki
    第77回日本循環器学会総会, Mar. 2013, English, 日本循環器学会, 横浜, Necl-5 regulates phenotypic reversion of VSMCs via ERK., Domestic conference
    Poster presentation

  • Elevation of plasma BMPER levels in patients with coronary artery disease
    Kobayashi Seimi, Ishida Tatsuro, Hirata Ken-ichi, Rikitake Yoshiyuki
    第77回日本循環器学会総会, Mar. 2013, Japanese, 日本循環器学会, 横浜, BMPER levels were elevated in patients with coronary artery disease., Domestic conference
    Oral presentation

  • Endothelial lipase in the heart modulates pressure overload-induced heart failure through fatty acid utilization
    Hideto Nakajima, Ishida Tatsuro, Michiko Monguchi, Maki Sasaki, Kensuke Kondo, Kenta Mori, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Toh Ryuji, Kobayashi Seimi, Hirata Ken-ichi
    Scientific Sessions 2012 American Heart Assosiation, Nov. 2012, English, American Heart Assosiation, Los Angeles, We have provided a novel finding that EL may be an alternative candidate to provide FA to the heart and regulate cardiac function. This effect seemed relevant particularly under the inflammatory condition where the action of LPL is downregulated., International conference
    Poster presentation

  • マウス内膜肥厚形成におけるネクチン様分子-5の役割
    呉羽 布美恵, Kobayashi Seimi, 衣笠 允雄, Hirata Ken-ichi, Rikitake Yoshiyuki
    第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, Necl-5がマウス頸動脈結紮後の内膜肥厚形成を促進することを示した。, Domestic conference
    Poster presentation

  • VEGFによる血管新生におけるNecl-5の役割
    衣笠 允雄, Kobayashi Seimi, 山名 祥太, 銕 祐介, 呉羽 布美恵, Hirata Ken-ichi, Rikitake Yoshiyuki
    第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, Necl-5が血管新生を促進することを示した。, Domestic conference
    Poster presentation

  • BMPER（BMP-binding endothelial regulator）による血管平滑筋細胞の骨芽細胞様細胞への形質転換
    Kobayashi Seimi, 衣笠 允雄, 銕 祐介, Hirata Ken-ichi, Rikitake Yoshiyuki
    第12回日本NO学会学術総会, Jun. 2012, Japanese, 日本NO学会, 神戸, BMPERが血管平滑筋細胞の骨芽細胞様細胞への形質転換を促進することを示した。, Domestic conference
    Poster presentation

  • Nectin-like Molecule-5 in Vascular Smooth Muscle Cells Regulates Intimal Thickening in Mice
    Fumie Kureha, Kobayashi Seimi, Mitsuo Kinugasa, Mitsuo Kinugasa, Hirata Ken-ichi, Rikitake Yoshiyuki
    第75回日本循環器学会総会・学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference
    Oral presentation

  • Necl-5/PVR/CD155, an Immunoglobulin-like Cell Adhesion Molecule, Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis
    Mitsuo Kinugasa, Mitsuo Kinugasa, Kobayashi Seimi, Shota Yamana, Shota Yamana, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Hirata Ken-ichi, Rikitake Yoshiyuki
    XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, 国際動脈硬化学会, シドニー, オーストラリア, International conference
    Poster presentation

  • Cardiac endothelial lipase expression is augmented in the early stage of heart failure
    Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi
    The XVI International Symposium on Atherosclerosis (ISA2012), Mar. 2012, English, The Australian Atherosclerosis Society, シドニー, オーストラリア, International conference
    Poster presentation

  • Cardiac Endothelial Lipase Expression is Augmented in a Murine Model of Heart Failure
    Hideto Nakajima, Ishida Tatsuro, Tomoko monguchi, Kensuke Kondo, Kenta Mori, Maki Sasaki, Minoru Hasokawa, Yoko Haraguchi, Tomoyuki Yasuda, Kobayashi Seimi, Hirata Ken-ichi
    日本循環器学会学術集会, Mar. 2012, Japanese, 日本循環器学会, 福岡, Domestic conference
    Oral presentation

  • Regulation of intimal thickeningfollowing carotid artery ligation in mice by the immunoglobulin-like cell adhesion molecule Necl-5
    Yoshiki Kubo, 久保 嘉輝, 呉羽 布美恵, Fumie Kureha, Seimi Kobayash, Kobayashi Seimi, 衣笠 允雄, Mitsuo Kinugasa, Miyata Muneaki, Miyata Muneaki, 三好 淳, Jun Miyoshi, Hirata Ken-ichi, Hirata Ken-ichi, Takai Yoshimi, Takai Yoshimi, Rikitake Yoshiyuki, Rikitake Yoshiyuki
    第34回日本分子生物学会年会, Dec. 2011, English, 日本分子生物学会, 横浜, Domestic conference
    Poster presentation

  • Necl-5, an Immunoglobulin-like Cell Adhesion Molecule, Regulates VEGF-induced Angiogenesis in Ischemia
    Mitsuo Kinugasa, Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Hideto Tawa, Hideto Tawa, Kobayashi Seimi, Hirata Ken-ichi
    第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference
    Poster presentation

  • Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells
    Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi
    第75回日本循環器学会総会・学術集会, Aug. 2011, English, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • The Immunoglobulin-like Molecule Necl-5/PVR Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis
    Mitsuo Kinugasa, Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Yusuke Kurogane, Fumie Kureha, Fumie Kureha, Kobayashi Seimi, Hirata Ken-ichi
    第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference
    Poster presentation

  • Increased expression of endothelial lipase in a murine model of heart failure
    中島英人, Ishida Tatsuro, 近藤健介, 森健太, 佐々木真希, 破磯川実, 原口英子, 安田知行, 篠原正和, Kobayashi Seimi, Hirata Ken-ichi
    第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference
    Poster presentation

  • BMPER Induced Osteogenic Differentiation in Human Coronary Artery Smooth Muscle Cells via NFkB Activation
    Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Noriaki Emoto, Hirata Ken-ichi
    第43回日本動脈硬化学会総会・学術集会, Jul. 2011, Japanese, 日本動脈硬化学会, 札幌, Domestic conference
    Poster presentation

  • Necl-5, an Immunoglobulin-like Cell Adhesion Molecule, Regulates VEGF-induced Angiogenesis in Ischemia
    Mitsuo Kinugasa, Rikitake Yoshiyuki, Yusuke Kurogane, Fumie Kureha, Hideto Tawa, Kobayashi Seimi, Hirata Ken-ichi
    第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference
    Poster presentation

  • Involvement of NFkB in BMPER-induced Osteogenic Differentiation of Human Coronary Artery Smooth Muscle Cells
    Kobayashi Seimi, Rikitake Yoshiyuki, Mitsuo Kinugasa, Ishida Tatsuro, Noriaki Emoto, Hirata Ken-ichi
    第75回日本循環器学会総会・学術集会, Mar. 2011, English, 日本循環器学会, 横浜, Domestic conference
    Oral presentation

  • Regulation of Angiogenesis by An Immunoglobulin-like Molecule Necl-5
    Miyata Muneaki, Rikitake Yoshiyuki, 天野 恭志, 衣笠 允雄, Kobayashi Seimi, 永松 裕一, 武田 匡史, 三好 淳, Hirata Ken-ichi, Takai Yoshimi
    ＢＭＢ2010 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会, Dec. 2010, Japanese, 日本分子生物学会, 日本生化学会, 神戸, Domestic conference
    Poster presentation

  • VEGFによる血管新生におけるNecl-5の役割
    衣笠 允雄, Rikitake Yoshiyuki, Kobayashi Seimi, 銕 祐介, Hirata Ken-ichi
    第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference
    Poster presentation

  • Regulation of Angiogenesis by the Immunoglobulin-like Molecule Necl-5
    Miyata Muneaki, Rikitake Yoshiyuki, Hisayuki Amano, Mitsuo Kinugasa, Kobayashi Seimi, Yuichi Nagamatsu, Masafumi Takeda, Jun Miyoshi, Hirata Ken-ichi, Takai Yoshimi
    第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会, Dec. 2010, Japanese, 日本分子生物学会/日本生化学会, 神戸, Domestic conference
    Poster presentation

  • FGD5によるVEGF誘導性催血管新生能の制御
    銕 佑介, Rikitake Yoshiyuki, Kobayashi Seimi, 衣笠 允雄, Hirata Ken-ichi
    第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference
    Oral presentation

  • BMP-binding endothelial regulator (BMPER)は培養ヒト冠動脈平滑筋細胞の骨芽細胞様分化転換を促進する
    Kobayashi Seimi, Rikitake Yoshiyuki, 衣笠 允雄, Hirata Ken-ichi
    第18回日本血管生物医学会学術集会, Dec. 2010, Japanese, 日本血管生物医学会, 大阪, Domestic conference
    Oral presentation

  • The WHHLMI Rabbit as a Model Animal for Coronary Spastic Angina.
    小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 一也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi
    4th Congress of Asian Federation of Laboratory Animal Science, Nov. 2010, English, Asian Federation of Laboratory Animal Science, Taipei, Taipei International Congress Center (Taiwan), International conference
    Poster presentation

  • 不安定狭心症のモデル動物としてのWHHLMIウサギの有用性。
    小林 努, Ishida Tatsuro, 新田 哲久, 園田 明永, 伊藤 隆, 平山 信恵, 山田 悟士, Kobayashi Seimi, 宮川 和也, 村田 喜代史, Hirata Ken-ichi, Shiomi Masashi
    第4回ウサギフォーラム, Jul. 2010, Japanese, ウサギフォーラム, 秋田, 秋田大学 (日本), Domestic conference
    Oral presentation

  • Role of Immunoglobulin-like Cell Adhesion Molecule Necl-5 in Vascular Endothelial Growth Factor-Induced Angiogenesis
    Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi
    第74回日本循環器学会総会, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference
    Poster presentation

  • BMP binding endothelial regulator (BMPER) is a novel regulator of human coronary artery calcification
    Kobayashi Seimi, Rikitake Yoshiyuki, Ishida Tatsuro, Emoto Noriaki, Hirata Kenichi
    第74回日本循環器学会総会, Mar. 2010, English, 日本循環器学会, 京都, Domestic conference
    Oral presentation

  • Immunoglobulin-like Cell Adhesion Molecule Necl-5 Regulates Vascular Endothelial Growth Factor-Induced Angiogenesis by Controlling the Interaction between VEGFR2 and Integrin αvβ3
    Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi
    Scientific Sessions 2009, Nov. 2009, English, 米国心臓協会, オーランド, アメリカ, International conference
    Poster presentation

  • Role of Immunoglobulin-like Cell Adhesion Molecule Necl-5 in VEGF-induced Angiogenesis
    Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi
    XV International Symposium on Atherosclerosis 2009, Jun. 2009, English, Boston Atherosclerosis Society, ボストン, アメリカ, International conference
    Oral presentation

  • Role of immunoglobulin-like cell adhesion molecule Necl-5 in VEGF-induced angiogenesis
    Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi
    XV International Symposium on Atherosclerosis, Jun. 2009, English, 国際動脈硬化学会, ボストン, アメリカ, International conference
    Poster presentation

  • Plasma tetrahydrobiopterin / dihydrobiopterin : A possible marker of endothelial dysfunction
    Yamashita Tomoya, Shinohara Masakazu, Sasaki Naoto, Kobayashi Seimi, Toh Ryuji, Hirata Kenichi, Kawashima Seinosuke
    第8回NO学会, May 2009, Japanese, 日本NO学会, 仙台, Domestic conference
    Poster presentation

  • Requirement of Small G Protein Rap1 and Rap1-binding Protein Afadin in Endothelial Cells for the Regulation of Angiogenesis
    Rikitake Yoshiyuki, Kobayashi Seimi, Takai Yoshimi, Hirata Kenichi
    第７３回日本循環学会総会, Mar. 2009, Japanese, 日本循環器学会, 大阪, Domestic conference
    Oral presentation

  • Plasma pteridine level as a biomarker of cardiovascular diseases
    Shinohara Masakazu, Yamashita Tomoya, Sasaki Naoto, Toh Ryuji, Kobayashi Seimi, Kawashima Seinosuke, Hirata Kenichi
    第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference
    Poster presentation

  • Oral Anti-CD3 Antibody Treatment Induces CD4+LAP+ Regulatory T Cells and Ameliorates the Development of Atherosclerosis in Mice
    Sasaki Naoto, Yamashita Tomoya, Shinohara Masakazu, Toh Ryuji, Kobayashi Seimi, Hirata Kenichi
    第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference
    Poster presentation

  • Inhibition of myocardin deteriorates cardiac function under beta-adrenergic stimulation
    Kobayashi Seimi, Toh Ryuji, Hirata Kenichi
    第72回日本循環器学会総会・学術総会, Mar. 2008, English, 日本循環器学会, 福岡, Domestic conference
    Oral presentation

  • Oral Anti-CD3 Antibody Treatment Induces CD4+LAP+ Regulatory T Cells and Ameliorates the Development of Atherosclerosis in Mice
    Sasaki Naoto, Yamashita Tomoya, Shinohara Masakazu, Toh Ryuji, Kobayashi Seimi, Hirata Kenichi
    第７9回AmericanHeartAssociationScientificSession, Nov. 2007, English, The American Heart Association, Orland, アメリカ, International conference
    Oral presentation

  • Myocardin is required to prevent mitochondrial damage and cardiac dysfunction in response to beta-adrenergic receptor stimulation
    Kobayashi Seimi, Toh Ryuji, Hirata Kenichi
    第７9回AmericanHeartAssociationScientificSession, Nov. 2007, English, The American Heart Association, Orland, アメリカ, International conference
    Oral presentation

■ Affiliated Academic Society
  • 日本循環器学会
    - Present

  • 日本心不全学会

  • 日本心臓リハビリテーション学会

  • 日本医学教育学会

  • 日本内科学会

■ Research Themes
  • de novo 脂肪酸合成経路に着目した心臓線維化の分子機序解明と治療法の確立
    小林 成美, 長尾 学, 篠原 正和
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2027

  • 地域医療機関と医学生を教育で結ぶプラットフォームの構築
    高桑 修, 柿崎 真沙子, 松尾 洋一, 山下 純世, 小林 成美
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 名古屋市立大学, 01 Apr. 2022 - 31 Mar. 2026

  • 心不全におけるグルタミン代謝制御機構の解明と新規治療戦略の構築
    小林 成美, 杜 隆嗣, 長尾 学
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024
    1) 不全心筋におけるグルタミン代謝制御機構を解明する 当初予定していた大動脈縮窄術による心不全モデルの実験系の結果にバラつきが大きく、動物モデルとしての安定した結果が得られなかったため、代替的にAngiotensinⅡの持続皮下投与による心肥大モデルを用いた検討を行った。AngiotensinⅡを投与したマウスの心臓組織ではグルタミン分解において、グルタミンからグルタミン酸への変換を触媒する酵素であるグルタミナーゼ１（GLS1）の発現がAngiotensinⅡ群で有意に増加していた。また、心肥大を心重量/体重比(mg/g)および心重量/脛骨長比(mg/mm)で評価したところ、いずれもAngiotensinⅡで有意に増加し、GLS1阻害薬（BPTES）投与によって抑制された。さらに、心臓切片における線維化面積はAngiotensinⅡ投与群で顕著に増加し、AngiotensinⅡ＋BPTES投与群では抑制された。同様に、線維化マーカーであるCol1a1の遺伝子発現も、AngiotensinⅡ投与群で増加し、AngiotensinⅡ＋BPTES投与群では、有意に抑制された。 不全心筋におけるグルタミン代謝の役割を解明するため、 [U-13C5]-グルタミンを用いて、ラット初代培養心筋細胞の細胞内の標識代謝物の追跡を行った（stable isotope tracing）。AngiotensinⅡによる刺激でグルタミン由来の代謝物は増加し、阻害薬・siRNAによるGLS1の阻害によってその増加は抑制された。 以上の実験より心臓リモデリングを来した心臓ではグルタミン分解が亢進し、その阻害がリモデリングの抑制に繋がることを証明した。

  • Kobayashi Seimi
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019, Principal investigator
    Anti-inflammatory action is expected as one of the effects of exercise therapy on cardiovascular diseases, but the mechanisms are unclear. We aimed to examine the mechanisms of anti-inflammatory roles of exercise therapy associated with lipid mediators. The 20-min exercise using cycle ergometer with the intensity around anaerobic threshold (AT) revealed to reduce the ratio of pro-inflammatory lipid mediators (PG group) /anti-inflammatory lipid mediators (Resolvin group) in the plasma of healthy adult volunteer. The vigorous exercise with the intensity of over 140%AT increased the ratio conversely. The results coincide with the idea that the exercise with the intensity of AT is safe and effective for the patients with cardiovascular diseases, and should be encouraged to continue.
    Competitive research funding

  • 心臓における細胞間接着分子nectin-2の機能解析
    小林 成美
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 2006 - 2007
    本研究では、初めて細胞間接着分子nectin-2が心筋細胞の介在板に存在し、心不全発症機序に関与していることを示した。 nectin-2 KOマウスの心臓は正常発育し、生理的条件下では正常心機能を呈する。しかし、大動脈縮窄による左室圧負荷モデルにおいて、心肥大の程度に差はなかったが、nectin-2 KOマウスでは野生型に比し著明な心収縮能の低下、肺うっ血(うっ血性心不全)、また、心筋内のびまん性線維化、心筋細胞のアポトーシスの増加などの異常が認められた。電子顕微鏡を用いた検討において、圧負荷下のnectin-2 KOマウスの心臓では、早期から介在板構造の異常(介在板の組み手構造が深くなり、mpofibrilの配列が乱れ間隙が生じる)が認められ、それはヒトの拡張型心筋症の組織に類似していた。 同モデルの心臓組織を用いたウエスタンブロッティングで、Akt、MAPK(p38MAPK、JNK、ERK)など、心不全、心肥大において重要な細胞内シグナル伝達系を検討したところ、MAPKのリン酸化はnectin-2 KOマウスにおいて術後に有意に増加しており、心臓におけるストレス増大を反映していると考えた。他の細胞間接着分子の発現は、N-cadherin、β-catenin、α-catenin、integrinβ1、desmogleinなど、adherens junctionとdesmosomeに関連する分子は手術前後で不変であった。gap junctionに存在するconnexin43はnectin-2 KOマウスの術後で減少傾向にあり、心不全期における同分子の発現に関する従来の報告と合致した。 本研究により、nectin-2が心肥大から心不全への移行に重要な分子であることが示唆された。

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