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NISHIMURA Mitsuhiro
Graduate School of Medicine / Center for Infectious Diseases (CID)
Assistant Professor

Research activity information

■ Paper
  • SatoshiNagamata, TaikiAoshi, AkikoKawabata, YoshiakiYamagishi, Nishimura Mitsuhiro, SoichiroKuwabara, KoukiMurakami, Yamada Hideto, Mori Yasuko
    The identification of Human herpesvirus 6B (HHV-6B) epitopes that are recognized by T-cells could contribute to the development of potential vaccines and immunotherapies. Here, we identified CD4+ and H-2Kd-restricted CD8+ T-cell epitopes on the glycoprotein Q1 of HHV-6B (BgQ1), which is a unique glycoprotein and essential for HHV-6B viral entry, by using in vivo electroporation with a plasmid DNA encoding BgQ1, overlapping peptides spanning the BgQ1 sequence, ELISPOT assay for quantification of gamma interferon (IFN-γ), and computer-based T-cell epitope prediction programs. The CD4+ and CD8+ T-cell epitopes identified in BALB/c mice in this study could be a good animal model system for use in the development of T-cell responses, inducing HHV-6B vaccines or immunotherapies.
    Mar. 2019, Sci Rep, 9(1) (1), 3911 - 3911, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Humanization of the murine neutralizing antibodies against human herpesvirus 6B
    WangB, Nishimura Mitsuhiro, MaekawaY, KotariT, OkunoT, Mori Yasuko
    Mar. 2019, J Virol, English
    [Refereed]
    Scientific journal

  • Aika Wakata, Satoshi Kanemoto, Huamin Tang, Akiko Kawabata, Mitsuhiro Nishimura, Chyntia Jasirwan, Nora Fahmy Mahmoud, Yasuko Mori
    American Society for Microbiology, Mar. 2018, Journal of Virology, 92(5) (5), English
    [Refereed]
    Scientific journal

  • Mitsuhiro Nishimura, Junjie Wang, Aika Wakata, Kento Sakamoto, Yasuko Mori
    American Society for Microbiology, Nov. 2017, Journal of Virology, 91(21) (21), English
    [Refereed]
    Scientific journal

  • Crystal Structure of Human Herpesvirus 6B Tegument Protein U14
    WangB, Nishimura Mitsuhiro, TangH, Kawabata Akiko, MahmoudNF, KhanlariZ, HamadaD, TsurutaH, MoriY
    May 2016, PLoS Pathog, 12(5) (5), e1005594, English
    [Refereed]
    Scientific journal

  • Purification, crystallization and X-ray diffraction study of the C-terminal domain of human herpesvirus 6A immediate early protein 2
    Junjie Wang, Mitsuhiro Nishimura, Aika Wakata, Yasuko Mori
    Kobe University School of Medicine, 2016, Kobe Journal of Medical Sciences, 62(6) (6), E142 - E149, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

■ MISC
■ Books And Other Publications
  • 週刊 医学のあゆみ / ウイルスベクターを用いたワクチン開発
    Nishimura Mitsuhiro, 森康子
    Others, Ishiyaku Pub,Inc., Feb. 2018, Japanese
    Scholarly book

  • Structural Aspects of Betaherpesvirus-Encoded Proteins.
    Nishimura M, MORI YASUKO
    Joint work, Adv Exp Med Biol, 2018, English
    Scholarly book

■ Lectures, oral presentations, etc.
  • Molecular interaction of HHV-6B gH/gL/gQ1/gQ2 complex with the cellular receptor and neutralizing antibodies
    Mitsuhiro Nishimura, Dian Novita Krisdianto, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Lidya Handayani Tjan, Takayuki Kato, Taiki Aoshi, Keiichi Namba, MORI YASUKO
    11th International Conference on HHV-6&7, Jun. 2019, English, Hotel Le Concorde Quebec, International conference
    Oral presentation

  • Humanization of murine neutralizing antibodies against gQ1 and gH of HHV-6B
    Lidya Handayari Tjan, Bochao Wang, Mitsuhiro Nishimura, MORI YASUKO
    11th International Conference on HHV-6&7, Jun. 2019, English, Hotel Le Concorde Quebec, International conference
    Oral presentation

  • Analysis of the functional domain of HHV-6A glycoprotein Q2 required for tetrameric formation and binding to receptor
    Aika Wakata, Mitsuhiro Nishimura, MORI YASUKO
    11th International Conference on HHV-6&7, Jun. 2019, English, Hotel Le Concorde Quebec, International conference
    Oral presentation

  • ヒトヘルペスウイルス6B抗原の感染防御免疫誘導能についての研究
    原 孝一, 西村 光弘, 王 博超, 河端 暁子, 湯 華民, 若田 愛加, Lystia Poetranto Anna, Handayani Tjan Lidya, 鈴木 亮, 青枝 大貴, MORI YASUKO
    第22回日本ワクチン学会学術集会, Dec. 2018, Japanese, 神戸国際会議場, Domestic conference
    Oral presentation

  • Molecular interaction of a human herpesvirus 6B glycoprotein complex with a host receptor and neutralizing antibodies
    Mitsuhiro Nishimura, Dian Novita Krisdianto, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Lidya Handayani Tjan, Takayuki Kato, Keiichi Namba, Taiki Aoshi, MORI YASUKO
    第66回日本ウイルス学会学術集会, Oct. 2018, English, Domestic conference
    Oral presentation

  • Isolation of avian influenza A(H4N6)viruses from ducks at a live-poultry market in Indonesia
    Rima R Prasetya, Emmanuel Djoko Poetrant, Aldise M Nastri, Jezzy R Dewantari, Krisnoadi Rahardio, Anna Lystia Poetranto, Laksmi Wulandari, Gatot Soegiarto, Mitsuhiro Nishimura, Yohko K Shimizu, MORI YASUKO, Kazufumi Shimizu
    第66回日本ウイルス学会学術集会, Oct. 2018, English, Domestic conference
    Oral presentation

  • Identification of the functional domain of HHV-6 glycoprotein Q2 responsible for receptor recognition
    Aika Wakata, Mitsuhiro Nishimura, MORI YASUKO
    第66回日本ウイルス学会学術集会, Oct. 2018, English, Domestic conference
    Oral presentation

  • Humanization of the neutralizing antibodies against human herpesvirus 6B
    Bochao Wang, Mitsuhiro Nishimura, MORI YASUKO
    第66回日本ウイルス学会学術集会, Oct. 2018, English, Domestic conference
    Oral presentation

  • Evolution of avian influenza A(H5N1)viruses from poultry in Indonesia
    Aldise M Nastri, Anna Lystia Poetranto, Emmanuel Djoko Poetrant, Jezzy R Dewantari, Rima R Prasetya, Krisnoadi Rahardio, Laksmi Wulandari, Gatot Soegiarto, Mitsuhiro Nishimura, Yohko K Shimizu, MORI YASUKO, Kazufumi Shimizu
    第68回日本ウイルス学会学術集会, Oct. 2018, English, Domestic conference
    Oral presentation

  • ヒトヘルペスウイルス6Bに対するヒト化抗体の作製及び解析
    王 博超, 西村光弘, MORI YASUKO
    第32回ヘルペスウイルス研究会, Jun. 2018, Japanese, Domestic conference
    Oral presentation

  • HHV-6B and its receptor usage
    MORI YASUKO, Satoshi Nagamata, KAWABATA AKIKO, Mitsuhiro Nishimura
    The 12th China-Japan International Conference of Virology, May 2018, English, International conference
    Oral presentation

  • ヒトヘルペスウイルス6B（HHV-6B)糖タンパク質複合体の感染防御免疫誘導の解析
    Kawabata Akiko, Nishimura Mitsuhiro, 湯 華民, 王 博超, 若田 愛加, Anna Lystia Poetranto, 原 孝一, 青枝 大貴, Mori Yasuko
    第21回日本ワクチン学会学術集会, Dec. 2017, Japanese, 第21回日本ワクチン学会学術集会, 福岡, Domestic conference
    Oral presentation

  • Structural analysis of human herpesvirus 6A immediate early protein 2 C-terminal domain
    Nishimura Mitsuhiro, Aika Wakata, Junjie Wang, Mori Yasuko
    第65回日本ウイルス学会学術集会, Oct. 2017, English, 第65回日本ウイルス学会各術集会学術事務局, 大阪, Domestic conference
    Oral presentation

  • HHV-6B envelope glycoprotein complex, gH/gL/gQ1/gQ2 is a key player for virus-induced cell fusion
    Aika Wakata, Satoshi Kanemoto, Anna Lystia Poetranto, Kawabata Akiko, Nishimura Mitsuhiro, Mori Yasuko
    第65回日本ウイルス学会学術集会, Oct. 2017, English, 第65回日本ウイルス学会各術集会学術事務局, 大阪, Domestic conference
    Oral presentation

  • Analysis of the immune response by human herpesvirus-6B glycoprotein complex
    Kawabata Akiko, Nishimura Mitsuhiro, Huamin Tang, Satoshi Nagamata, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Kouichi Hara, Taiki Aoshi, Mori Yasuko
    第65回日本ウイルス学会学術集会, Oct. 2017, English, 第65回日本ウイルス学会各術集会学術事務局, 大阪, Domestic conference
    Oral presentation

  • HHV-6A immediate early protein 2 shows the similarity with EBNA1 and LANA in its C-terminal domain
    Nishimura Mitsuhiro, Junjie Wang, Aika Wakata, Kento Sakamoto, Mori Yasuko
    42nd Annual International Herpesvirus Workshop, Aug. 2017, English, IHW2017, ゲント, ベルギー, International conference
    Oral presentation

  • The gH/gL/gQ1/gQ2 complex could induce protective immunity for HHV-6B
    Kawabata Akiko, Nishimura Mitsuhiro, Huamin Tang, Satoshi Nagamata, Bochao Wang, Aika Wakata, Anna Lystia Poetranto, Koichi Hara, Taiki Aoshi, Mori Yasuko
    10th International Conference on HHV-6&7, Jul. 2017, English, 10th International Conference on HHV-6&7, ベルリン, ドイツ, International conference
    Oral presentation

  • Structure-based analysis of human herpesvirus 6A immediate early protein 2
    Nishimura Mitsuhiro, Aika Wakata, Kento Sakamoto, Wang Junjie, Mori Yasuko
    10th International Conference on HHV-6&7, Jul. 2017, English, 10th International Conference on HHV-6&7, ベルリン, ドイツ, International conference
    Oral presentation

  • Role of the tyrosine-based motif in the cytoplasmic tail of the HHV-6A glycoprotein B
    Satoshi Kanemoto, Ji Luo, Bochao Wang, Hiroshi Tanimoto, Aika Wakata, Nishimura Mitsuhiro, Mori Yasuko
    10th International Conference on HHV-6&7, Jul. 2017, English, 10th International Conference on HHV-6&7, ベルリン, ドイツ, International conference
    Poster presentation

  • Coexpression of HHV-6B gH/gL/gQ1/gQ2 complex with gB induces cell-cell fusion in CD134 expression cells, and gQ1 and gQ2 are key players for their mediated-cell fusion
    Aika Wakata, Satoshi Kanemoto, Anna L. Poetranto, Kawabata Akiko, Nishimura Mitsuhiro, Mori Yasuko
    10th International Conference on HHV-6&7, Jul. 2017, English, 10th International Conference on HHV-6&7, ベルリン, ドイツ, International conference
    Oral presentation

  • ヒトヘルペスウイルス 6Bの免疫誘導についての解析
    Kawabata Akiko, Nishimura Mitsuhiro, 湯 華民, 王 博超, 若田 愛加, Anna L. Poetranto, 原 孝一, 青枝 大貴, Mori Yasuko
    第31回ヘルペスウイルス研究会, Jun. 2017, Japanese, 第31回ヘルペスウイルス研究会, 松江, Domestic conference
    Oral presentation

  • ヒトヘルペスウイルス6A 転写活性化因子 IE2 C 末端領域の立体構造解析
    Nishimura Mitsuhiro, 若田 愛加, 王 俊杰, Mori Yasuko
    第31回ヘルペスウイルス研究会, Jun. 2017, Japanese, 第31回ヘルペスウイルス研究会, 松江, Domestic conference
    Oral presentation

  • HHV-6B糖タンパク質によって引き起こされる宿主細胞膜融合の解析
    若田 愛加, 金本 慧史, Anna L. Poetranto, Kawabata Akiko, Nishimura Mitsuhiro, Mori Yasuko
    第31回ヘルペスウイルス研究会, Jun. 2017, Japanese, 第31回ヘルペスウイルス研究会, 松江, Domestic conference
    Oral presentation

  • Functional analysis of the human herpesvirus 6 envelope glycoprotein B
    Satoshi Kanemoto, Ji Luo, Bochao Wang, Hiroshi Tanimoto, Aika Wakata, Kawabata Akiko, Nishimura Mitsuhiro, Mori Yasuko
    第31回ヘルペスウイルス研究会, Jun. 2017, Japanese, 第31回ヘルペスウイルス研究会, 松江, Domestic conference
    Oral presentation

  • The role of U14 in human herpesvirus-6 infection
    Kawabata Akiko, Nishimura Mitsuhiro, Satoshi Serada, Tetsuji Naka, Mori Yasuko
    The 64th Annual Meeting of the JapaneseSociety for Virology, Oct. 2016, Japanese, 日本ウイルス学会, 札幌, Domestic conference
    Oral presentation

  • Structual insight into the function of human herpesvirus-6B tegument protein U14
    Nishimura Mitsuhiro, Bocho Wang, Kento Sakamoto, Kawabata Akiko, Huamin Tang, Daizo Hamada, Hiroki Tsuruta, Mori Yasuko
    The 64th Annual Meeting of the JapaneseSociety for Virology, Oct. 2016, Japanese, 日本ウイルス学会, 札幌, Domestic conference
    Oral presentation

■ Research Themes
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