Research activity information

• Dec. 2019 Asian Pacific Association for Computational Mechanics, APACM Award for Young Investigators in Computational Mechanics

  IMAI Yohsuke


• May 2019 日本計算工学会, 第24回計算工学講演会 グラフィックスアワード優秀賞

  Japan society


• May 2019 日本計算工学会, 第24回計算工学講演会 グラフィックスアワード特別賞（Meshman賞）

  Japan society


• Jul. 2018 Japan Association for Computational Mechanics, JACM Fellows Award

  IMAI YOHSUKE

  Japan society


• 17 Sep. 2017 日本機械学会, 日本機械学会計算力学部門 業績賞

  Japan society


• 04 Dec. 2015 青葉工学振興会, 第9回青葉工学振興会賞

  Publisher


• Jul. 2014 Dynamics of Capsules, Vesicles, and Cells in Flow, Best Poster Award

  International society


• Apr. 2014 文部科学省, 平成26年度科学技術分野の文部科学大臣表彰 若手科学者賞

  International academic award


• Mar. 2014 Advances in Computation Fluid-Structure Interaction and Flow Simulation, Poster Award (Second Place)

  International society


• Aug. 2013 7th Asian Pacific Conference on Biomechanics, APCB2013 Award for Excellent Thesis

  International society


• Mar. 2013 Journal of Biomechanical Science and Engineering, JBSE Graphics of the Year Award

  Official journal


• Jun. 2012 日本計算工学講演会, 第17回計算工学講演会 ベストペーパーアワード

  Japan society


• Jan. 2012 日本機械学会バイオエンジニアリング部門, 日本機械学会バイオエンジニアリング部門 瀬口賞

  Japan society


• Nov. 2011 Journal of Biomechanical Science and Engineering, JBSE Papers of the Year Award

  Official journal


• Jul. 2010 日本計算力学連合, JACM Award for Young Investigators in Computational Mechanics

  Publisher


• Apr. 2010 日本機械学会, 日本機械学会奨励賞（研究）

  Publisher


• Jan. 2010 青葉工学振興会, 第15回青葉工学研究奨励賞

  Publisher


• Dec. 2008 International Conference on Biomedical Engineering, Young Investigator Award Merit Prize

  International society


• Feb. 2007 財団法人手島工業教育資金団, 手島記念研究賞（博士論文賞）

  Publisher


• Dec. 2006 第20回数値流体力学シンポジウム実行委員会, 第20回数値流体力学シンポジウム ベストCFDグラフィックス・アワード最優秀賞

  Japan society


• Nov. 2006 日本機械学会計算力学部門, 日本機械学会第19回計算力学講演会 ビジュアリゼーションコンテスト優秀作品賞

  Japan society


• Dec. 2005 第19回数値流体力学シンポジウム実行委員会, 第19回数値流体力学シンポジウム ベストCFDグラフィックス・アワード最優秀賞

  Japan society


• Nov. 2005 日本機械学会計算力学部門, 日本機械学会第18回計算力学講演会 ビジュアリゼーションコンテスト最優秀作品賞

  Japan society


• Dec. 2004 第18回数値流体力学シンポジウム実行委員会, 第18回数値流体力学シンポジウム ベストCFDグラフィックス・アワード優秀賞

  Japan society

• Effect of menstrual cycle and menopause on human gastric electrophysiology

  Alexandria H. Lim, Chris Varghese, Gabrielle H. Sebaratnam, Gabriel Schamberg, Stefan Calder, Armen A. Gharibans, Christopher N. Andrews, Daphne Foong, Vincent Ho, Shunichi Ishida, Yohsuke Imai, Michelle R. Wise, Greg O’Grady

  This study evaluates gastric electrophysiology in relation to the menstrual cycle using a novel noninvasive high-resolution methodology, revealing substantial variations in gastric activity with menstrual cycling and menopause. Gastric slow-wave frequency is significantly higher in the luteal versus follicular menstrual phase. Computational modeling predicts that this difference translates to higher rates of gastric mixing and liquid emptying in the luteal phase, which is consistent with previous experimental data evaluating menstrual cycling effects on gastric emptying.

  American Physiological Society, Jul. 2024, American Journal of Physiology-Gastrointestinal and Liver Physiology, 327(1) (1), G47 - G56

  Scientific journal


• Folding of a growing hyperelastic sheet in a viscous fluid

  Togo Hayashi, Hironori Takeda, Shunichi Ishida, Yohsuke Imai

  Understanding the growth-induced deformation of soft materials in viscous environments is important for a variety of problems in nature and engineering. Here, we focus on the fluid–structure interaction of a hyperelastic sheet growing in an incompressible Newtonian fluid in the Stokes flow regime. We develop a computational framework for simulating this problem, where the isogeometric boundary integral method is used with the Kirchhoff–Love shell formulation and elastic–plastic decomposition of the deformation gradient tensor. We quantify the relative effects of the growth rate, the sheet bending rigidity, and the fluid viscosity on the fold formation and development of the growing sheet. Our results suggest that the viscous resistance to in-plane deformation promotes fold formation, whereas the viscous resistance to out-of-plane deformation suppresses fold development. We also investigate the effects of the thickness and aspect ratio of the rectangular sheet. Finally, we compare the growth- and prestrain-induced deformations to find a common behavior of sheets under viscous environments.

  AIP Publishing, May 2024, Physics of Fluids, 36(5) (5)

  Scientific journal


• Deformation and breakup of a ferrofluid droplet in shear flow under magnetic field

  Yuto Kawabata, Shunichi Ishida, Yohsuke Imai

  Effects of magnetic field applied perpendicular to a shear plane in shear flow on the deformation of a ferrofluid droplet are numerically investigated. The boundary integral method is employed to solve the two-phase Stokes flow under a uniform magnetic field. When the magnetic field is applied perpendicular to the shear plane, the deformation of the droplet in the shear plane decreases. The magnetic field causes the droplet to elongate in the y-direction, and its cross-sectional radius in shear plane decreases. Consequently, the apparent capillary number in the shear plane decreases, thereby suppressing the droplet deformation. Droplet breakup is also suppressed by imposing a magnetic field perpendicular to the shear plane, thereby increasing the critical capillary numbers. The critical capillary numbers for the magnetic Bond numbers Bo = 2.0 and 4.0 increase to approximately 110% and 130%, respectively, than those without magnetic field. Furthermore, an equation for the theoretical prediction of the droplet deformation under a magnetic field in shear flow is presented, which is based on the small deformation theory, the decrease in the cross-sectional radius, and the boundary conditions at the droplet interface. The theoretical prediction agrees well with the numerical results for the variation in the magnetic susceptibility of the droplet as well as the viscosity ratio between the external fluid and the ferrofluid droplet under a small deformation. The critical capillary numbers under a magnetic field can also be predicted by using the numerical results without a magnetic field.

  AIP Publishing, Mar. 2024, Physics of Fluids, 36(3) (3)

  Scientific journal


• A computational model of red blood cells using an isogeometric formulation with T-splines and a lattice Boltzmann method

  Yusuke Asai, Shunichi Ishida, Hironori Takeda, Gakuto Nakaie, Takuya Terahara, Yasutoshi Taniguchi, Kenji Takizawa, Yohsuke Imai

  Elsevier BV, Mar. 2024, Journal of Fluids and Structures, 125, 104081 - 104081

  Scientific journal


• Isogeometric boundary element analysis of creasing of capsule in simple shear flow

  Hironori Takeda, Yusuke Asai, Shunichi Ishida, Yasutoshi Taniguchi, Takuya Terahara, Kenji Takizawa, Yohsuke Imai

  Elsevier BV, Jan. 2024, Journal of Fluids and Structures, 124, 104022 - 104022

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mechanical investigation of mechanisms of the midgut protrusion and rotation using numerical analysis

  SAIKI Michina, TAKEDA Hironori, KAWABATA Yuto, ISHIDA Shunichi, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 2023, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2023.34, 2B05, Japanese


• Fluid–structure interaction analysis of content transport by peristalsis in the digestive tract considering active contraction

  KURIHARA Tomofumi, TAKEDA Hironori, ISHIDA Shunichi, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 2023, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2023.34, 2G09, Japanese


• Numerical Analysis of Tortuosity of Blood Vessels Considering Mechanical Constraints of Surrounding Tissues

  MATSUMOTO Taku, TAKEDA Hironori, ISHIDA Shunichi, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 2023, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2023.34, 1B02, Japanese


• Effects of peristaltic amplitude and frequency on gastric emptying and mixing: a simulation study

  Rika Ebara, Shunichi Ishida, Taimei Miyagawa, Yohsuke Imai

  The amplitude and frequency of peristaltic contractions are two major parameters for assessing gastric motility. However, it is not fully understood how these parameters affect the important functions of the stomach, such as gastric mixing and emptying. This study aimed to quantify the effects of peristaltic amplitude and frequency on gastric mixing and emptying using computational fluid dynamics simulation of gastric flow with an anatomically realistic model of the stomach. Our results suggest that both the increase and decrease in peristaltic amplitude have a significant impact on mixing strength and emptying rate. For example, when the peristaltic amplitude was 1.2 times higher than normal, the emptying rate was 2.7 times faster, whereas when the amplitude was half, the emptying rate was 4.2 times slower. Moreover, the emptying rate increased more than proportionally with the peristaltic frequency. The nearest contraction wave to the pylorus and the subsequent waves promoted gastric emptying. These results suggest the importance of maintaining parameters within normal ranges to achieve healthy gastric function.

  The Royal Society, Jan. 2023, Journal of The Royal Society Interface, 20(198) (198)

  [Refereed]

  Scientific journal


• Peristaltic transport of a power-law fluid induced by a single wave: A numerical analysis using the cumulant lattice Boltzmann method

  Kohei Maeyama, Shunichi Ishida, Yohsuke Imai

  Peristaltic pumping is the primary mechanism of food transport in the human intestine. Intestinal contents are often modeled as power-law fluids with low-behavior indices ( n < 1). Peristaltic flows were studied for periodic contraction waves ([Formula: see text]) with infinitely long wavelengths ([Formula: see text]) in the Stokes flow regime ([Formula: see text]). However, the peristaltic flow generated by an isolated contraction wave with a short wavelength at nonzero Reynolds numbers is more relevant to physiological conditions. In this study, we investigated the peristaltic transport of a power-law fluid with a low behavior index of n = 0.21 at nonzero Reynolds numbers up to Re = 10, generated by a single short contraction wave. First, we investigated the analytical solution for the peristaltic transport of the power-law fluid for [Formula: see text] and [Formula: see text]. The analytical solution shows that the discharge flow rate of a power-law fluid generated by a single contraction wave is much smaller than that of a Newtonian fluid ( n = 1). Next, we investigated the peristaltic transport for [Formula: see text] 10 using the cumulant lattice Boltzmann method. The numerical results demonstrate that the discharge flow rate for the power-law fluid sharply increased owing to the inertia effect. The power-law fluid induces an asymmetric flow field with respect to the contraction wave at smaller Reynolds numbers than Newtonian fluids. The inertia effect was increased by the sharpness of the contraction wave. These results suggest that intestinal contents can be transported more quickly by an isolated contraction wave with a shorter wavelength when the contents have low consistency indices or when the contraction wave has a large propagation velocity.

  AIP Publishing, Nov. 2022, Physics of Fluids, 34(11) (11), 111911 - 111911

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of cilia-induced surface velocity on cerebrospinal fluid exchange in the lateral ventricles

  Haruki Yoshida, Shunichi Ishida, Taiki Yamamoto, Takayuki Ishikawa, Yuichi Nagata, Kazuhito Takeuchi, Hironori Ueno, Yohsuke Imai

  Ciliary motility disorders are known to cause hydrocephalus. The instantaneous velocity of cerebrospinal fluid (CSF) flow is dominated by artery pulsation, and it remains unclear why ciliary dysfunction results in hydrocephalus. In this study, we investigated the effects of cilia-induced surface velocity on CSF flow using computational fluid dynamics. A geometric model of the human ventricles was constructed using medical imaging data. The CSF produced by the choroid plexus and cilia-induced surface velocity were given as the velocity boundary conditions at the ventricular walls. We developed healthy and reduced cilia motility models based on experimental data of cilia-induced velocity in healthy wild-type and Dpcd-knockout mice. The results indicate that there is almost no difference in intraventricular pressure between healthy and reduced cilia motility models. Additionally, it was found that newly produced CSF from the choroid plexus did not spread to the anterior and inferior horns of the lateral ventricles in the reduced cilia motility model. These findings suggest that a ciliary motility disorder could delay CSF exchange in the anterior and inferior horns of the lateral ventricles.

  The Royal Society, Aug. 2022, Journal of The Royal Society Interface, 19(193) (193)

  [Refereed]

  Scientific journal


• Particle segregation using crystal-like structure of capsules in wall-bounded shear flow

  Shunichi Ishida, Ryota Matsumoto, Daiki Matsunaga, Yohsuke Imai

  American Physical Society (APS), Jun. 2022, Physical Review Fluids, 7(6) (6)

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Isogeometric analysis of midgut molphogenesis accompanied by biological tissue growth

  SAIKI Michina, TAKEDA Hironori, ISHIDA Shunichi, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 2022, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2022.33, 1F15, Japanese


• Fluid–Structure Interaction Analysis for Deformation of Blood Vessels Considering Mechanical Constraints of Surrounding Tissues

  MATSUMOTO Taku, TAKEDA Hironori, ISHIDA Shunichi, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 2022, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2022.33, 1F18, Japanese


• Liquid transport produced by a cluster of peristaltic contractions in a circular channel

  Tomoki Oyama, Shunichi Ishida, Kohei Maeyama, Taimei Miyagawa, Yohsuke Imai

  American Physical Society (APS), Sep. 2021, Physical Review Fluids, 6(9) (9)

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach

  Tim Hsu‐Han Wang, Timothy R. Angeli, Shunichi Ishida, Peng Du, Armen Gharibans, Niranchan Paskaranandavadivel, Yohsuke Imai, Taimei Miyagawa, Thomas L. Abell, Gianrico Farrugia, Leo K. Cheng, Gregory O’Grady

  Wiley, Jan. 2021, Physiological Reports, 8(24) (24)

  [Refereed]

  Scientific journal


• Multiscale modeling of human cerebrovasculature: A hybrid approach using image-based geometry and a mathematical algorithm.

  Satoshi Ii, Hiroki Kitade, Shunichi Ishida, Yohsuke Imai, Yoshiyuki Watanabe, Shigeo Wada

  The cerebral vasculature has a complex and hierarchical network, ranging from vessels of a few millimeters to superficial cortical vessels with diameters of a few hundred micrometers, and to the microvasculature (arteriole/venule) and capillary beds in the cortex. In standard imaging techniques, it is difficult to segment all vessels in the network, especially in the case of the human brain. This study proposes a hybrid modeling approach that determines these networks by explicitly segmenting the large vessels from medical images and employing a novel vascular generation algorithm. The framework enables vasculatures to be generated at coarse and fine scales for individual arteries and veins with vascular subregions, following the personalized anatomy of the brain and macroscale vasculatures. In this study, the vascular structures of superficial cortical (pial) vessels before they penetrate the cortex are modeled as a mesoscale vasculature. The validity of the present approach is demonstrated through comparisons with partially observed data from existing measurements of the vessel distributions on the brain surface, pathway fractal features, and vascular territories of the major cerebral arteries. Additionally, this validation provides some biological insights: (i) vascular pathways may form to ensure a reasonable supply of blood to the local surface area; (ii) fractal features of vascular pathways are not sensitive to overall and local brain geometries; and (iii) whole pathways connecting the upstream and downstream entire-scale cerebral circulation are highly dependent on the local curvature of the cerebral sulci.

  Jun. 2020, PLoS computational biology, 16(6) (6), e1007943, English, International magazine

  [Refereed]

  Scientific journal


• Complex viscosity of dilute capsule suspensions: a numerical study

  Daiki MATSUNAGA, Yohsuke IMAI

  Last, Japan Society of Mechanical Engineers, 2020, Journal of Biomechanical Science and Engineering

  [Refereed]

  Scientific journal


• Perioperative Hemodynamic Changes in the Thoracic Aorta in Patients With Aortic Valve Stenosis: A Prospective Serial 4D-Flow MRI Study.

  Hiroki Kamada, Hideki Ota, Masanori Nakamura, Yohsuke Imai, Shunichi Ishida, Wenyu Sun, Ko Sakatsume, Ichiro Yoshioka, Yoshikatsu Saiki, Kei Takase

  This study investigated hemodynamic changes in the thoracic aorta and aortic arch branches before and after aortic valve replacement (AVR) by 4D-flow MRI in patients with aortic valve stenosis (AS). Thoracic 4D-flow MRI was performed in 10 AS patients before and after AVR (mean 27 ± 1.9 days). Fifteen aortic planes and 3 aortic arch branches planes were set to evaluate the mean volume flow rate in each plane during a cardiac cycle and the angle between the main flow direction in a specified plane and the axial direction of the aorta. We also focused on the distribution and magnitude of helicity density to evaluate the flow complexity. A significant increase in the volume flow rate after AVR was found in the ascending aorta (before 59.2 ± 8.7 mL/s vs after 77.3 ± 6.2 mL/s, P < 0.05) and the aortic arch branches (before 26.5 ± 2.8 mL/s vs after 35.8 ± 3.3 mL/s, P < 0.001). The flow angle significantly decreased in the ascending aorta (before 39.2 ± 2.7 degree vs after 25.2 ± 1.7°, P < 0.0001) and the arch aorta (before 19.3 ± 2.0 degree vs after 13.4 ± 0.9°, P < 0.001). The volume flow rate in the ascending aorta and the arch branches increased within 1 month after AVR, showing an increased blood supply to the upper body, including to the brain. The postoperative change was accompanied with an increased blood flow in the ascending aorta and a decreased flow complexity proximal to the arch branches.

  2020, Seminars in thoracic and cardiovascular surgery, 32(1) (1), 25 - 34, English, International magazine

  [Refereed]

  Scientific journal


• Shear viscosity of bimodal capsule suspensions in simple shear flow

  Hiroki Ito, Daiki Matsunaga, Yohsuke Imai

  Last, Nov. 2019, Physical Review Fluids, 4, 113601, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Capture event of platelets by bolus flow of red blood cells in capillaries

  Naoki Takeishi, Yohsuke Imai, Shigeo Wada

  Nov. 2019, Journal of Biomechanical Science and Engineering, 14(3) (3), 18 - 00535, English

  [Refereed]

  Scientific journal


• A computational fluid dynamics simulation of liquid swallowing by impaired pharyngeal motion: bolus pathway and pharyngeal residue

  Jun Ohta, Shunichi Ishida, Tetsuaki Kawase, Yukio Katori, Yohsuke Imai

  Common practices to improve the ability to swallow include modifying physical properties of foods and changing the posture of patients. Here, we quantified the effects of the viscosity of a liquid bolus and patient posture on the bolus pathway and pharyngeal residue using a computational fluid dynamics simulation. We developed a computational model of an impaired pharyngeal motion with a low pharyngeal pressure and no pharyngeal adaptation. We varied viscosities from 0.002 to 1 Pa·s and postures from -15° to 30° (from nearly vertical to forward leaning). In the absence of pharyngeal adaptation, a honey-like liquid bolus caused pharyngeal residue, particularly in the case of forward-leaning postures. Although the bolus speed was different among viscosities, the final pathway was only slightly different. The shape, location, and tilting of the epiglottis effectively invited a bolus to two lateral pathways, suggesting a high robustness of the swallowing process.NEW & NOTEWORTHY Thickening agents are often used for patients with dysphagia. An increase in bolus viscosity not only reduces the risk of aspiration but also can cause a residual volume in the pharynx. Because information obtained from videofluoroscopic swallowing studies is only two-dimensional, measurement of pharyngeal residue is experimentally difficult. We successfully quantified the three-dimensional bolus pathway and the pharyngeal residual volume using computational modeling and simulation.

  Nov. 2019, American Journal of Physiology Gastrointestinal and Liver Physiology, 317(6) (6), G784 - G792, English, International magazine

  [Refereed]

  Scientific journal


• Quantification of gastric emptying caused by impaired coordination of pyloric closure with antral contraction: a simulation study

  Shunichi Ishida, Taimei Miyagawa, Gregory O'Grady, Leo K. Cheng, Yohsuke Imai

  Proper coordination of gastric motor functions is required for healthy gastric emptying. However, pyloric function may be impaired by functional disorders or surgical procedures. Here, we show how coordination between pyloric closure and antral contraction affects the emptying of liquid contents. We numerically simulated fluid dynamics using an anatomically realistic gastrointestinal geometry. Peristaltic contractions in the proximal stomach resulted in gastric emptying at a rate of 3-8 ml min-1. When the pylorus was unable to close, the emptying rate increased to 10-30 ml min-1, and instantaneous retrograde flow from the duodenum to the antrum occurred during antral relaxation. Rapid emptying occurred if the pylorus began to open during the terminal antral contraction, and the emptying rate was negative if the pylorus only opened during the antral relaxation phase. Our results showed that impaired coordination between antral contraction and pyloric closure can result in delayed gastric emptying, rapid gastric emptying and bile reflux.

  Aug. 2019, Journal of the Royal Society Interface, 16(157) (157), 20190266 - 20190266, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hemorheology in dilute, semi-dilute, and dense suspensions of red blood cells

  Naoki Takeishi, Marco E. Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt

  Aug. 2019, Journal of Fluid Mechanics, 872, 818 - 848, English

  [Refereed]

  Scientific journal


• A numerical analysis of rheology of capsule suspensions using a GPU-accelerated boundary element method

  Yohsuke Imai, Daiki Matsunaga

  Springer Basel, 2018, Modeling and Simulation in Science, Engineering and Technology, 213 - 251, English

  In book


• Factors Diminishing Cytoadhesion of Red Blood Cells Infected by Plasmodium falciparum in Arterioles

  Shunichi Ishida, Akihisa Ami, Yohsuke Imai

  Sep. 2017, BIOPHYSICAL JOURNAL, 113(5) (5), 1163 - 1172, English

  [Refereed]

  Scientific journal


• Nodal cilia-driven flow: Development of a computational model of the nodal cilia axoneme

  T. Omori, H. Sugai, Y. Imai, T. Ishikawa

  Aug. 2017, JOURNAL OF BIOMECHANICS, 61, 242 - 249, English

  [Refereed]

  Scientific journal


• A BOUNDARY ELEMENT METHOD FOR CELLULAR SCALE PHYSIOLOGICAL FLOW PROBLEMS: PASSIVE MOTIONS OF RED BLOOD CELLS AND ACTIVE MOTIONS OF CILIA AND FLAGELLA

  Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Yamaguchi Medal 受賞講演

  Jul. 2017, The 26th Congress of the International Society of Biomechanics (ISB 2017), English

  [Invited]


• Capture of microparticles by bolus flow of red blood cells in capillaries

  Naoki Takeishi, Yohsuke Imai

  Jul. 2017, SCIENTIFIC REPORTS, 7, 5381, English

  [Refereed]

  Scientific journal


• Shear-induced platelet aggregation and distribution of thrombogenesis at stenotic vessels

  Hiroki Kamada, Yohsuke Imai, Masanori Nakamura, Takuji Ishikawa, Takami Yamaguchi

  May 2017, MICROCIRCULATION, 24(4) (4), e12355, English

  [Refereed]

  Scientific journal


• Integrated nanobiomechanics of the living system

  T. Yamaguchi, Y. Imai, T. Ishikawa

  Apr. 2017, 19th International Conference on Finite Elements in Flow Problems, English


• RELATIONSHIP BETWEEN PERISTALTIC CONTRACTION AND GASTRIC MIXING

  Yohsuke Imai, Taimei Miyagawa, Shunichi Ishida, Takami Yamaguchi, Takuji Ishikawa

  Dec. 2016, Abstracts Book of the 16th International Conference on Biomedical Engineering, 167, English


• DEVELOPMENT OF A BIOMECHANICAL MODEL OF CELL BEHAVIOR SUBJECTED TO CYCLIC STRETCH

  Fumiyasu Saito, Yohsuke Imai, Shunichi Ishida, Toshihiro Omori, Takuji Ishikawa

  Dec. 2016, Abstracts Book of the 16th International Conference on Biomedical Engineering, 163, English


• A NUMERICAL ANALYSIS OF THE LATERAL MIGRATION OF FLOWING CELLS

  Stephanie Nix, Yohsuke Imai, Takuji Ishikawa

  Dec. 2016, Abstracts Book of the 16th International Conference on Biomedical Engineering, 54, English


• Relationship between gastric motility and liquid mixing in the stomach

  Taimei Miyagawa, Yohsuke Imai, Shunichi Ishida, Takuji Ishikawa

  Dec. 2016, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 311(6) (6), G1114 - G1121, English

  [Refereed]

  Scientific journal


• Numerical analysis of cell adhesion in capillary flow

  NAOKI TAKEISHI, YOHSUKE IMAI, SHUNICHI ISHIDA, TOSHIHIRO OMORI, ROGER KAMM, TAKUJI ISHIKAWA

  Nov. 2016, The 69th Annual Meetin g of The American Physical Society, Bulletin of the American Physical Society, DED 2016, 61, 72, English


• Reorientation of a single red blood cell during sedimentation

  D. Matsunaga, Y. Imai, C. Wagner, T. Ishikawa

  Nov. 2016, JOURNAL OF FLUID MECHANICS, 806, 102 - 128, English

  [Refereed]

  Scientific journal


• Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling

  Rachel Berry, Taimei Miyagawa, Niranchan Paskaranandavadivel, Peng Du, Timothy R. Angeli, Mark L. Trew, John A. Windsor, Yohsuke Imai, Gregory O'Grady, Leo K. Cheng

  Nov. 2016, AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 311(5) (5), G895 - G902, English

  [Refereed]

  Scientific journal


• Cell adhesion during bullet motion in capillaries

  Naoki Takeishi, Yohsuke Imai, Shunichi Ishida, Toshihiro Omori, Roger D. Kamm, Takuji Ishikawa

  Aug. 2016, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 311(2) (2), H395 - H403, English

  [Refereed]

  Scientific journal


• Similarities and differences between flow mode of a leukocyte and circulating tumor cell in microvessels

  Naoki Takeishi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2016, Summer Biomechanics, Bioengineering and Biotransport Conference, 742, English


• Numerical methods for simulating blood flow at macro, micro, and multi scales

  Yohsuke Imai, Toshihiro Omori, Yuji Shimogonya, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2016, JOURNAL OF BIOMECHANICS, 49(11) (11), 2221 - 2228, English

  [Refereed]

  Scientific journal


• Lateral migration of a capsule in a parabolic flow

  S. Nix, Y. Imai, T. Ishikawa

  Jul. 2016, JOURNAL OF BIOMECHANICS, 49(11) (11), 2249 - 2254, English

  [Refereed]

  Scientific journal


• Response to the Letter to the Editor "Hemodynamics in the Microcirculation" by A. G. Koutsiaris

  Toshihiro Omori, Yohsuke Imai, Kenji Kikuchi, Takuji Ishikawa, Takami Yamaguchi

  Springer New York LLC, Apr. 2016, Annals of Biomedical Engineering, 44(4) (4), 1323, English


• Distraction osteogenesis of the sternum for thoracic expansion in a severe case of jeune syndrome: A preliminary report

  Yoshimichi Imai, Ryuta Kitanishi, Yoshikatsu Saiki, Atsushi Takeda, Masahiro Tachi

  Taylor and Francis Ltd, Mar. 2016, Journal of Plastic Surgery and Hand Surgery, 50(3) (3), 180 - 183, English

  [Refereed]

  Scientific journal


• Nutrient uptake in a suspension of squirmers

  Takuji Ishikawa, Shunsuke Kajiki, Yohsuke Imai, Toshihiro Omori

  Feb. 2016, JOURNAL OF FLUID MECHANICS, 789, 481 - 499, English

  [Refereed]

  Scientific journal


• Bio-Micropump by Using A Flagellate Propulsive Force of Escherichia coli

  Kenji Kikuchi, Ryo Matsuura, Hironori Ueno, Yohsuke Imai, Noriaki Matsuki, Takami Yamaguchi, Takuji Ishikawa

  2016, The World Congress on Engineering 2016, ICSBB15, 515 - 518, English

  [Refereed]

  International conference proceedings


• Rheology of a dense suspension of spherical capsules under simple shear flow

  D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa

  Jan. 2016, JOURNAL OF FLUID MECHANICS, 786, 110 - 127, English

  [Refereed]

  Scientific journal


• Deformation of a micro-torque swimmer

  Takuji Ishikawa, Tomoyuki Tanaka, Yohsuke Imai, Toshihiro Omori, Daiki Matsunaga

  Jan. 2016, PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 472(2185) (2185), 20150604, English

  [Refereed]

  Scientific journal


• A numerical model of a red blood cell infected by Plasmodium falciparum malaria: coupling cell mechanics with ligand-receptor interactions

  Shunichi Ishida, Yohsuke Imai, Yuki Ichikawa, Stephanie Nix, Daiki Matsunaga, Toshihiro Omori, Takuji Ishikawa

  2016, SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 17(1) (1), 454 - 461, English

  [Refereed]

  Scientific journal


• Flow of a circulating tumor cell and red blood cells in microvessels

  Naoki Takeishi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Dec. 2015, PHYSICAL REVIEW E, 92(6) (6), 063011, English

  [Refereed]

  Scientific journal


• Shape matters: Near-field fluid mechanics dominate the collective motions of ellipsoidal squirmers

  K. Kyoya, D. Matsunaga, Y. Imai, T. Omori, T. Ishikawa

  Dec. 2015, PHYSICAL REVIEW E, 92(6) (6), 063027, English

  [Refereed]

  Scientific journal


• Quantification of hydrodynamic factors influencing cell lateral migration

  STEPHANIE NIX, YOHSUKE IMAI, TAKUJI ISHIKAWA

  Nov. 2015, 68th Annual Meeting of the Division of Fluid Dynamics, Bulletin of the American Physical Society, DFD 2015, 60, 116, English


• Deformable micro torque swimmer

  TAKUJI ISHIKAWA, TOMOYUKI TANAKA, TOSHIHIRO OMORI, YOHSUKE IMAI

  Nov. 2015, 68th Annual Meeting of the Division of Fluid Dynamics, Bulletin of the American Physical Society, DFD 2015, 60, 72, English


• Rheological analysis of dense capsule suspensions – effect of volume fraction

  Daiki Matsunaga, Yohsuke Imai, Christian Wagner, Takuji Ishikawa

  Oct. 2015, The 3rd International Workshops on Advances in Computational Mechanics(IWACOM-III), 128, English


• Graphics processing unit computing of cellular flow and adhesion in microvessels

  Yohsuke Imai, Naoki Takeishi, Shunichi Ishida, Takuji Ishikawa

  Oct. 2015, The 3rd International Workshops on Advances in Computational Mechanics(IWACOM-III), 47, English


• Mechanics of Nodal Cilia in Early Mouse Embryo

  Toshihiro Omori, Hiroto Sugai, Yohsuke Imai, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS8-15, English


• Development of a Numerical Model of Cytoskeleton Dynamics

  Fumiyasu Saito, Yohsuke Imai, Shunichi Ishida, Toshihiro Omori, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS3-7, English


• Clarification of Relationship between Gastric Mixing and Movement of Wall

  Taimei Miyagawa, Yohsuke Imai, Shunichi Ishida, Takami Yamaguchi, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS3-6, English


• Orientation Angle of a Single Red Blood Cell during Sedimentation

  Daiki Matsunaga, Yohsuke Imai, Christian Wagner, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS3-2, English


• Hydrodynamic Interaction between the Small Microparticles and Red Blood Cells in Microchannel

  Naoki Takeishi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS3-1, English


• Swimming Behavior of a Model Ciliate near a Fluid-Air or a Fluid-Solid Interface

  Junichi Manabe, Toshihiro Omori, Yohsuke Imai, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, PS1-10, English


• A Numerical Simulation of Cytoadhesion and Rosette Formation of Red Blood Cells Infected by Malaria

  Yohsuke Imai, Yuki Ichikawa, Shunichi Isida, Daiki Matsunaga, Stephanie Nix, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, OS2-2, English


• Effect of Flow Curvature on the Migration of Blood Cells

  Stephanie Nix, Yohsuke Imai, Takuji Ishikawa

  Sep. 2015, The 8th Asian-Pacific Conference on Biomechanics, OS2-1, English


• Simulations of a swimming microorganism near an fluid-air or an fluid-solid interface

  Junichi Manabe, Toshihiro Omori, Yohsuke Imai, Takuji Ishikawa

  Sep. 2015, Computational Fluid Dynamics (CFD) in Medicine and Biology II, English


• Separation of motile bacteria using drift force near a wall

  Takuji Ishikawa, Tatsuya Shioiri, Keiko Numayama-Tsuruta, Hironori Ueno, Yohsuke Imai, Takami Yamaguch

  Sep. 2015, Computational Fluid Dynamics (CFD) in Medicine and Biology II, English


• Structure of outer arm dynein molecule in respiratory cilia suggests an alternative mechanism of force generation

  H. Ueno, H. Bui, T. Ishikawa, Y. Imai, T. Yamaguchi, T. Ishikawa

  BioMed Central Ltd., Jul. 2015, Cilia, (1) (1), English

  [Refereed]

  Scientific journal


• Cellular Scale Physiological Flow: Active Swimming Sperm Cells and Passive Flowing Red Blood Cells

  Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi

  Jul. 2015, 13th U.S. National Congress on Computational Mechanics, English


• Viscosity Reduction in Bimodal Suspensions of Two Types of Capsules

  Yohsuke Imai, Hiroki Ito, Daiki Matsunaga, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2015, 13th U.S. National Congress on Computational Mechanics, English


• Peclet Number Of Ciliary Transport On The Surface Of The Tracheal Lumen

  Kouki Kiyota, Hironori Ueno, Keiko Numayama-Tsuruta, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jun. 2015, SB3C2015, 223, English


• A Computational Study Of Red Blood Cells In Stokes Flow: From Single Cellular Mechanics To Suspension Rheology

  Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jun. 2015, SB3C2015, 256, English


• Rheology of A Red Blood CEll Suspension Computing with A Boundary Element-Finite Wlement Coupled Method

  Toshihiro Omori, Yohsuke Imai, Takuji Ishikawa

  Mar. 2015, The 18th International Conference on Finite Elements in Flow Problems FEF2015, 23, English


• Visualization of intestinal peristalsis of mosquito midgut by using micro x-ray imaging

  Kenji Kikuchi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  2015, International Symposium on Integrated Nanobiomechanics, English

  International conference proceedings


• Hemodynamics in the Microcirculation and in Microfluidics

  Toshihiro Omori, Yohsuke Imai, Kenji Kikuchi, Takuji Ishikawa, Takami Yamaguchi

  Jan. 2015, ANNALS OF BIOMEDICAL ENGINEERING, 43(1) (1), 238 - 257, English

  [Refereed]

  Scientific journal


• Deformation of a spherical capsule under oscillating shear flow

  D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa

  2015, JOURNAL OF FLUID MECHANICS, 762, 288 - 301, English

  [Refereed]

  Scientific journal


• A full GPU implementation of a numerical method for simulating capsule suspensions

  D.Matsunaga, Y.Imai, T.Omori, T.Ishikawa, T.Yamaguchi

  Although boundary element (BE) based methods are highly accurate for simulating capsule suspensions in Stokes flows, computational time has been a major issue, even when only a few capsules are simulated. We propose a full graphics processing unit (GPU) implementation of a numerical method coupling the BE method of fluid mechanics with the finite element method of membrane mechanics. In single GPU computing, the performance achieves 0.12 TFlop/s when computing one capsule (2562 nodes and 5120 elements) and 0.29 TFlop/s for two capsules. The performance increases with the number of capsules, achieving a maximum of 0.59 TFlop/s. We also implement a multi-GPU method with the data communication overlapping the computation. A weak scaling test shows perfect scalability for any number of computational nodes per GPU, indicating that the communication time is completely hidden. For a practical use of the present results, we estimate the computational time required for 10000 time steps. When we simulate one capsule and two capsules on one GPU, only 2.0 and 9.1 minutes are required to complete the simulation, respectively, and a simulation with 256 capsules on 16 GPUs takes 3.8 days.

  The Japan Society of Mechanical Engineers, Dec. 2014, Journal of Biomechanical Science and Engineering, 9(3) (3), 14-00039 - 00039-14-00039, English

  [Refereed]

  Scientific journal


• Swimming behavior of a model microorganism at a fluid-air interface

  Junichi Manabe, Kohei Kyoya, Toshihiro Omori, Yohsuke Imai, Takuji Ishikawa

  Nov. 2014, The Sixth International Symposium on Aero Aqua Bio-mechanisms, 37, English


• Lateral migration of a spherical capsule near a plane wall in Stokes flow

  S. Nix, Y. Imai, D. Matsunaga, T. Yamaguchi, T. Ishikawa

  Oct. 2014, Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 90(4) (4)

  [Refereed]

  Scientific journal


• Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension

  Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi

  Oct. 2014, COMPUTATIONAL MECHANICS, 54(4) (4), 933 - 941, English

  [Refereed]

  Scientific journal


• Lateral migration of a spherical capsule near a plane wall in Stokes flow

  S. Nix, Y. Imai, D. Matsunaga, T. Yamaguchi, T. Ishikawa

  Oct. 2014, PHYSICAL REVIEW E, 90(4) (4), 043009, English

  [Refereed]

  Scientific journal


• Modeling of Flow in the Stomach

  Yohsuke Imai, Ikuma Kobayashi, Taimei Miyagawa, Shunichi Ishida, Takuji Ishikawa, Takami Yamaguchi

  Sep. 2014, THE FOURTH JAPAN-SWITZERLAND WORKSHOP ON BIOMECHANICS, 102, English


• Numerical modeling of cellular flow and adhesion in microvessels

  Yohsuke Imai, Naoki Takeishi, Akihisa Ami, Takami Yamaguchi, Takuji Ishikawa

  Japan Soc. of Med. Electronics and Biol. Engineering, Aug. 2014, Transactions of Japanese Society for Medical and Biological Engineering, 52, 45, English

  [Refereed]

  Scientific journal


• A numerical method for simulating gastricflow

  Taimei Miyagawa, Yohsuke Imai, Takami Yamaguchi, takuji Ishikawa

  Jul. 2014, 11th World Congress on Computational Mechanics, 303, English


• Rheological analysis of capsule suspensions containing different size capsules

  Hiroki Ito, Yohsuke Imai, Daiki Matsunaga, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, 11th World Congress on Computational Mechanics, 303, English


• Rheological analysis of dense capsule suspension under simple shear flow condition

  Daiki Matsunaga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Dyna Caps 2014, English


• Numerical Analysis of Capsule Suspensions Containing Two Different siza Capsules

  Hiroki Ito, Yohsuke Imai, Daiki Matsunaga, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Dyna Caps 2014, English


• Collective swimming of ellipoidal squimers

  Takuji Ishikawa, Kohei Kyoya, Daiki Matsunaga, Yohsuke Imai, Toshihiro Omori

  Jul. 2014, Dyna Caps 2014, English


• Margination of large cells in microchannels

  Yohsuke Imai, Naoki Takeishi, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Dyna Caps 2014, English


• Development of a numerical model for analysis of ciliary motions

  H. Sugai, T. Omori, Y. Imai, T. Ishikawa

  Jul. 2014, 7th WORLD CONGRESS OF BIOMECHANICS, English


• Effect of Shear Gradient and Wall on Capsule Lateral Migration

  S. Nix, Y. Imai, T. Yamaguchi, T. Ishikawa

  Jul. 2014, 7th WORLD CONGRESS OF BIOMECHANICS, English


• Multi-scale computational study on the formation and destruction of primary thrombus under the influence of the blood flow and red blood cells

  H. Kmada, Y. Imai, T. Ishikawa, T. Yamaguchi

  Jul. 2014, 7th WORLD CONGRESS OF BIOMECHANICS, English


• A numerical simulation on the motion ofmalaria-infected cells in microcirculatory blood flow

  Y. Imai, A, Ami, T. Yamaguchi, T, Ishikawa

  Jul. 2014, 7th WORLD CONGRESS OF BIOMECHANICS, English


• Numerical analysis of hydrodynamic behavior of circulating tumor cells in microchannels

  N. Takeishi, Y. Imai, T. Yamaguchi, T. Ishikawa

  Jul. 2014, 7th WORLD CONGRESS OF BIOMECHANICS, English


• Development of an Intracellular Structure Model for Ciliary Motion Analysis

  Hiroto Sugai, Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 17 - 18, English


• Nutrient Uptake in a Suspension of Model Microorganisms

  Takuji Ishikawa, Shunsuke Kajiki, Yohsuke Imai, Toshihiro Omori

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 15 - 16, English


• Capsule Lateral Migration in an Unbounded Plane Poiseuille Flow and Near-wall Shear Flow

  Stephanie Nix, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 13 - 14, English


• Rheology of a Red Blood Cell Suspension from Dilute to Semi-dilute Regime

  Toshihiro Omori, Yohsuke Imai, Takami Imai, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 11 - 12, English


• Hydrodynamic Interction between a Circulating Tumor Cell and Blood Cells in Microcirculation

  Naoki Takeishi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 9 - 10, English


• Numerical Modeling of the Adhesion of Red Blood Cells Infected by Plasmodium Falciparum Malaria in Microcirculatory Blood Flow

  Yohsuke Imai, Akihisa Ami, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 7 - 8, English


• A Numerical Analysis of Cellular Adhesion to Planar Wall Mediated by Ligand-Receptor Interactions

  Yuki Ichikawa, Yohsuke Imai, Daiki Matsunaga, Stephanie Nix, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 5 - 6, English


• Computational Study on Thrombogenesis

  Hiroki Kamada, Yohsuke Imai, Takuji Ishikawa, Takami Ymaguchi

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 3 - 4, English


• Shear Stress Distribution in the Stomach

  Taimei Miyagawa, Yohsuke Imai, Sunichi Ishida, Takami Yamaguchi, Takuji Ishikawa

  Jul. 2014, Internationnal Symposium on Integrated Nanobiomechanics, 1 - 2, English


• Structure of Dimeric Axonemal Dynein in Cilia Suggests an Alternative Mechanism of Force Generation

  Hironori Ueno, Khanh Huy Bui, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi, Takashi Ishikawa

  Jul. 2014, CYTOSKELETON, 71(7) (7), 412 - 422, English

  [Refereed]

  Scientific journal


• Nutrient uptake in a suspension of model microorganisms

  Takuji Ishikawa, Shunsuke Kajiki, Yohsuke Imai, Toshihiro Omori

  Apr. 2014, COMPSAFE, 347 - 348, English


• Rheological analysis of dense capsule suspension under Stokes flow condition

  Daiki Matsunaga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Mar. 2014, Advances in Computational Fluid-Structure Interaction and Flow Simulation, Poster Session, English


• Numerical analysis of a red blood cell flowing through a thin micropore

  Toshihiro Omori, Haruki Hosaka, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jan. 2014, Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 89(1) (1), English

  [Refereed]

  Scientific journal


• Flow-induced deformation of a capsule in unbounded stokes flow

  Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi

  Kluwer Academic Publishers, 2014, Lecture Notes in Computational Vision and Biomechanics, 12, 101 - 117, English

  [Refereed]

  Scientific journal


• Numerical analysis of a red blood cell flowing through a thin micropore

  Toshihiro Omori, Haruki Hosaka, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jan. 2014, PHYSICAL REVIEW E, 89(1) (1), 013008, English

  [Refereed]

  Scientific journal


• Fluctuation of cilia-generated flow on the surface of the tracheal lumen

  Kouki Kiyota, Hironori Ueno, Keiko Numayama-Tsuruta, Tomofumi Haga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Jan. 2014, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 306(2) (2), L144 - L151, English

  [Refereed]

  Scientific journal


• Separation of motile bacteria using drift velocity in a microchannel

  Takuji Ishikawa, Tatsuya Shioiri, Keiko Numayama-Tsuruta, Hironori Ueno, Yohsuke Imai, Takami Yamaguchi

  2014, LAB ON A CHIP, 14(5) (5), 1023 - 1032, English

  [Refereed]

  Scientific journal


• Leukocyte margination at arteriole shear rate

  Naoki Takeishi, Yohsuke Imai, Keita Nakaaki, Takami Yamaguchi, Takuji Ishikawa

  American Physiological Society, 2014, Physiological Reports, 2(6) (6), e12037, English

  [Refereed]

  Scientific journal


• A numerical analysis of a capsule containing multiple small capsules in simple shear flow

  Yuki Ichikawa, Yohsuke Imai, Daiki Matsunaga, Takami Yamaguchi, Takuji Ishikawa

  Dec. 2013, APCOM2013 & ISCM2013 Conference Handbook, 15, English


• Numerical analysis of margination of a cancer cell in microcirculation

  N. Takeishi, Y. Imai, T. Yamaguchi, T. Ishikawa

  Dec. 2013, APCOM2013 & ISCM2013 Conference Handbook, 18, English


• Solid particle motion in the stomach during gastric mixing

  Taimei Miyagawa, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Dec. 2013, The15th International Conference on Biomedical Enginnering, 17 - 18, English


• Nutrient uptake in a suspension of squirmers

  Shunsuke Kajiki, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Nov. 2013, Bulletin of the American Physical Society, 58, 409, English


• Viscoelasticity of dilute capsule suspension under Stokes flows

  Daiki Matsunaga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Nov. 2013, Bulletin of the American Physical Society, 58, 97, English


• Viscosity of Dense Capsule Suspension Under Simple Shear FLow Condition

  Daiki Matsunaga, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Nov. 2013, 7th East Asian Consortium on Biomedical Engineering, Proceeding Book, 80 - 81, English


• Margination of leukocyte in different sizes of circular micro-channel

  Naoki takeishi, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Nov. 2013, 7th East Asian Consortium on Biomedical Engineering, Proceeding Book, 78 - 79, English


• Entrapment of Ciliates at the Water-Air Interface

  Jonathan Ferracci, Hironori Ueno, Keiko Numayama-Tsuruta, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Oct. 2013, PLoS ONE, 8(10) (10), e75238, English

  [Refereed]

  Scientific journal


• Computational study on thrombus formation regulated by platelet glycoprotein and blood flow shear

  Hiroki Kamada, Yohsuke Imai, Masanori Nakamura, Takuji Ishikawa, Takami Yamaguchi

  Sep. 2013, MICROVASCULAR RESEARCH, 89, 95 - 106, English

  [Refereed]

  Scientific journal


• Effect of Aeration on the Bioconvection Pattern in a Microalgae Suspension

  Y. Nonaka, H. Ueno, K. Numayama, T. Omori, Y. Imai, T. Yamaguchi, T. Ishikawa

  Aug. 2013, APCB2013 Proceedings, S12 - 002, English


• Modeling of cytoadhesion in malaria infection

  A. Ami, Y. Imai, T. Ishikawa, T. Yamaguchi

  Aug. 2013, APCB2013 Proceedings, S4 - 3, English


• Mechanism of capsule migration near a plane wall

  S. Nix, Y. Imai, D. Matsunaga, T. Yamaguchi, T. Ishikawa

  Aug. 2013, APCB2013 Proceedings, S4 - 020, English


• Numerical simulation of motion of solid particles in the stomach

  T. Miyagawa, Y. Imai, T. Yamaguchi, T. Ishikawa

  Aug. 2013, APCB2013 Proceedings, S4 - 019, English


• Margination of white blood cell in various sizes of circular micro-channel

  N. Takeishi, Y. Imai, T. Ishikawa, T. Yamaguchi

  Aug. 2013, APCB2013 Proceedings, S4 - 3, English


• Collective Swimming of Ellipsoidal Microorganisms

  K. Kyoya, D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa

  Aug. 2013, APCB2013 Proceedings, S4 - 014, English


• Integrated Biomechanics for Physiological Flow Problems

  T. Yamaguchi, Y. Imai, T. Omori, H. Ueno, K. Numayama-Tsuruta, T. Ishikawa

  Aug. 2013, APCB2013 The7thAsian Pacific Conference on Biomechanics, ILS4 - 009, English


• COMPUTATIONAL BIOMECHANICS ON BLOOD FLOW FROM CELLULAR TO

  T. yamaguchi, Y. Imai, T. Ishikawa

  Jun. 2013, COMPDYN 2013, S2090, English


• Shear-induced diffusion of red blood cells in a semi-dilute suspension

  T. Omori, T. Ishikawa, Y. Imai, T. Yamaguchi

  Jun. 2013, Journal of Fluid Mechanics, 724, 154 - 174, English

  [Refereed]

  Scientific journal


• The near-wall motion of a capsule in stokes flow

  S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 52 - 53, English

  International conference proceedings


• Simulation of nutrient uptake of a swimming model microorganism by boundary element method

  S. Kajiki, K. Kyoya, D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 42 - 43, English

  International conference proceedings


• Numerical simulation of adhesion of malaria-infected red blood cells

  A. Ami, Y. Imai, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 38 - 39, English

  International conference proceedings


• Numerical analysis of swimming microorganisms by a boundary element method

  K. Kyoya, D. Matsunaga, Y. Imai, T. Yamaguchi, T. Ishikawa

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 44 - 45, English

  International conference proceedings


• Numerical analysis of dynamics of solid particles in the stomach

  T. Miyagawa, Y. Imai, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 48 - 49, English

  International conference proceedings


• Margination of various cells in microcirculation

  N. Takeishi, Y. Imai, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 36 - 37, English

  International conference proceedings


• Gradient diffusion of red blood cells in blood flow through a Y-shape microchannel

  C. Chuang, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 78 - 79, English

  International conference proceedings


• A numerical analysis of complex viscosity of dilute capsule suspension

  D. Matsunaga, Y. Imai, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 104 - 105, English

  International conference proceedings


• A numerical analysis of bimodal capsule suspensions

  H. Ito, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Mar. 2013, 6th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 106 - 107, English

  International conference proceedings


• Membrane tension of red blood cells pairwisely interacting in simple shear flow

  Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi

  Feb. 2013, Journal of Biomechanics, 46(3) (3), 548 - 553, English

  [Refereed]

  Scientific journal


• Antral recirculation in the stomach during gastric mixing

  Yohsuke Imai, Ikuma Kobayashi, Shunichi Ishida, Takuji Ishikawa, Martin Buist, Takami Yamaguchi

  2013, American Journal of Physiology - Gastrointestinal and Liver Physiology, 304(5) (5), G536 - G542, English

  [Refereed]

  Scientific journal


• Computational analysis on the mechanical interaction between a thrombus and red blood cells: Possible causes of membrane damage of red blood cells at microvessels

  Hiroki Kamada, Yohsuke Imai, Masanori Nakamura, Takuji Ishikawa, Takami Yamaguchi

  Dec. 2012, MEDICAL ENGINEERING & PHYSICS, 34(10) (10), 1411 - 1420, English

  [Refereed]

  Scientific journal


• Tension of red blood cell membrane in simple shear flow

  T. Omori, T. Ishikawa, D. Barthes-Biesel, A. -V. Salsac, Y. Imai, T. Yamaguchi

  Nov. 2012, PHYSICAL REVIEW E, 86(5) (5), 056321, English

  [Refereed]

  Scientific journal


• Off-plane motion of a non-spherical capsule in simple shear flow

  T. Omori, T. Ishikawa, Y. Imai, T. Yamaguchi

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 331 - 331, English

  International conference proceedings


• Measurement of ciliary flow generated on the surface of tracheal lumen

  K. Kiyota, H. Ueno, T. Ishikawa, K. Numayama-Tsuruta, Y. Imai, T. Omori, T. Yamaguchi

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 334 - 334, English

  International conference proceedings


• Hydrodynamical entrapment of ciliates at the air-liquid interface

  J. Ferracci, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi, T. Ishikawa

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 107 - 107, English

  International conference proceedings


• Gradient diffusion of red blood cells in blood flow through a Y-shape microchannel

  C. Chuang, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 330 - 330, English

  International conference proceedings


• Analysis of red blood cell behavior in a narrow tube

  H. Hosaka, T. Omori, Y. Imai, T. Yamaguchi, T. Ishikawa

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 330 - 330, English

  International conference proceedings


• 3D-PTV measurement of the phototactic movement of algae in shear flow

  T. Maeda, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Nov. 2012, Bulletin of the American Physical Society 65th Annual Meeting of the APS Division of Fluid Dynamics, 49 - 49, English

  International conference proceedings


• Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels

  Davod Alizadehrad, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

  Oct. 2012, JOURNAL OF BIOMECHANICS, 45(15) (15), 2684 - 2689, English

  [Refereed]

  Scientific journal


• Lateral migration of capsules in a near-wall shear flow

  S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Oct. 2012, International Computational Mechanics Symposium 2012 (USB), USB Memory, English

  International conference proceedings


• Development of a GPU-Implemented BEM solver for biological cell suspensions

  Y. Imai, D. Matsunaga, K. Kyoya, T. Omori, T. Ishikawa, T. Yamaguchi

  Oct. 2012, International Computational Mechanics Symposium 2012, USB Memory, English

  International conference proceedings


• GPU computing for patient-specific model of pulmonary airflow

  T. Yamaguchi, Y. Imai, T. Miki, T. Ishikawa

  Sep. 2012, Computational Modelling of Objects Represented in Images: Fundamentals, Methods and Applications, 239 - 242, English


• Role of fluid mechanics in collective motions of bacteria

  T. Ishikawa, N. Yoshida, H. Ueno, M. Wiedeman, Y. Imai, T. Yamaguchi

  Sep. 2012, 9th International Conference on Flow Dynamics Proceedings, 732 - 733, English

  International conference proceedings


• Computational analysis on the mechanical interaction between a thrombus and red blood cells

  H. Kamada, Y. Imai, M. Nakamura, T. Ishikawa, T. Yamaguchi

  Sep. 2012, ECCOMAS 2012 Congress Proceedings, CD-ROM, English

  International conference proceedings


• Reorientation of a non-spherical micro-capsule in shear flow

  T. Ishikawa, T. Omori, Y. Imai, T. Yamaguchi

  Aug. 2012, Abstract Book of the 23rd International Congress of Theoretical and Applied Mechanics, 106 - 106, English

  International conference proceedings


• Particle based simulation of microcirculation using a parallel computation

  T. Yamaguchi, Y. Imai, T. Ishikawa

  Jul. 2012, Biorheology, 49, 181 - 181, English

  International conference proceedings


• Hemodynamics in the pulmonary artery of a patient with pneumothorax

  J-J Christophe, T. Ishikawa, Y. Imai, K. Takase, M. Thiriet, T. Yamaguchi

  Jul. 2012, MEDICAL ENGINEERING & PHYSICS, 34(6) (6), 725 - 732, English

  [Refereed]

  Scientific journal


• Hydrodynamic entrapment of ciliates at the air-liquid interface

  J. Ferracci, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi, T. Ishikawa

  Jun. 2012, Softflow 2012 – Biological Complex Fluids, 36 - 37, English

  International conference proceedings


• Dynamics of capsules near a plane wall

  S. Nix, Y. Imai, T. Ishikawa, T. Yamaguchi

  Jun. 2012, Softflow 2012 – Biological Complex Fluids, 76 - 76, English

  International conference proceedings


• Deposition of micrometer particles in pulmonary airways during inhalation and breath holding

  Yohsuke Imai, Takahito Miki, Takuji Ishikawa, Takayuki Aoki, Takami Yamaguchi

  Jun. 2012, JOURNAL OF BIOMECHANICS, 45(10) (10), 1809 - 1815, English

  [Refereed]

  Scientific journal


• Energy efficiency in collective motions of swimming bacteria

  T. Ishikawa, N. Yoshida, H. Ueno, M. Wiedeman, Y. Imai, T. Yamaguchi

  May 2012, IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering, CD-ROM, English

  International conference proceedings


• Computational biomechanics of physiological flow

  T. Yamaguchi, T. Ishikawa, Y. Imai, H. Ueno, K. Numayama-Tsuruta, T. Omori

  Mar. 2012, Biological Flow: A Conference to Celebrate the 70th Birthday of Timothy J. Padley FRS, 38, English


• Rheology of a dilute suspention of red blood cells in simple shear flow

  T. Omori, T. Ishikawa, Y. Imai, T. Yamaguchi

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 153 - 154, English

  International conference proceedings


• Quantifying characteristics of blood cell at dense cellullar flow

  D. Alizadehrad, Y. Imai, T. Ishikawa, T. Yamaguchi

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 111 - 112, English

  International conference proceedings


• Hydrodynamic entrapment of ciliates at the interface fluid-air

  J. Ferracci, T. Ishikawa, H. Ueno, K. Numayama, Y. Imai, T. Yamaguchi

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 115 - 116, English

  International conference proceedings


• Effect of constitutive law on the lateral migration of a capsule near a wall

  S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 145 - 146, English

  International conference proceedings


• Collective Diffusion of red blood cells from high concentration to low

  C. Chuang, T. Ishikawa, H. Ueno, K. Numayama, Y. Imai, T. Yamaguchi

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 109 - 110, English

  International conference proceedings


• A particle model of cellular flow in microcirculation

  T. Yamaguchi, T. Ishikawa, Y. Imai

  Mar. 2012, 18th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 61 - 64, English

  International conference proceedings


• Reorientation of a Nonspherical Capsule in Creeping Shear Flow

  Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  Mar. 2012, PHYSICAL REVIEW LETTERS, 108(13) (13), 138102, English

  [Refereed]

  Scientific journal


• Parallel simulation of cellular flow in microvessels using a particle method

  Davod Alizadehrad, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

  Feb. 2012, Journal of Biomechanical Science and Engineering, 7(1) (1), 57 - 71, English

  [Refereed]

  Scientific journal


• Radial dispersion of tracer particles through high-hematocrit blood flow within a capillary tube

  M. Saadatmand, T. Ishikawa, N. Matsuki, H. J. Abdekhodaie, Y. Imai, H. Ueno, T. Yamaguchi

  Feb. 2012, Nano-Biomedical Engineering, Imperial College Press, 134 - 143, English

  Research society


• Inertial migration of cancer cells in blood flow in microchannels

  Tatsuya Tanaka, Takuji Ishikawa, Keiko Numayama-Tsuruta, Yohsuke Imai, Hironori Ueno, Takefumi Yoshimoto, Noriaki Matsuki, Takami Yamaguchi

  Feb. 2012, BIOMEDICAL MICRODEVICES, 14(1) (1), 25 - 33, English

  [Refereed]

  Scientific journal


• Entrapment of fresh water ciliates at the interface fluid-air

  J. Ferracci, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Feb. 2012, Nano-Biomedical Engineering, Imperial College Press, 70 - 76, English

  Research society


• Computational biomechanics of blood flow at macro- and micro-scales

  T. Yamaguchi, T. Ishikawa, Y. Imai

  Feb. 2012, Nano-Biomedical Engineering, Imperial College Press, 53 - 62, English

  Research society


• Behavior of a spherical capsule in simple shear flow near an infinite plane

  S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Feb. 2012, Nano-Biomedical Engineering, Imperial College Press, 122 - 127, English

  Research society


• Micro-flow visualization of magnetic nanoparticles for biomedical applications

  R. Lima, R. J. Joseyphus, T. Ishikawa, Y. Imai, T. Yamaguchi

  Bentham Science Publishers Ltd., 2012, Single and Two-Phase Flows on Chemical and Biomedical Engineering, 600 - 612, English

  [Refereed]

  In book


• Blood flow behavior in microchannels: Past, current and future trends

  R. Lima, T. Ishikawa, Y. Imai, T. Yamaguchi

  Bentham Science Publishers Ltd., 2012, Single and Two-Phase Flows on Chemical and Biomedical Engineering, 513 - 547, English

  [Refereed]

  In book


• Boundary element analysis of the multi-capsule flow using an ultra-high speed GPGPU computation

  D. Matsunaga, Y. Imai, T. Ishikawa, T. Yamaguchi

  2012, WIT Transactions on Modelling and Simulation, 53, 201 - 208, English

  [Refereed]

  International conference proceedings


• Boundary element analysis of deformation and movement of a capsule and a red blood cell close to the wall

  S. Nix, Y. Imai, T. Ishikawa, T. Yamaguchi

  2012, WIT Transactions on Modelling and Simulation, 53, 191 - 199

  [Refereed]

  International conference proceedings


• Flow visualization of trace particles and Red Blood Cells in a microchannel with a diverging and converging bifurcation

  V. Leble, C. Fernandes, R. Dias, R. Lima, T. Ishikawa, Y. Imai, T. Yamaguchi

  2012, COMPUTATIONAL VISION AND MEDICAL IMAGE PROCESSING: VIPIMAGE 2011, 209 - 211, English

  [Refereed]

  International conference proceedings


• 8F25 Inertial migration of cancer cells in high hematocrit blood flow.

  TANAKA Tatsuya, ISHIKAWA Takuji, NUMAYAMA-TSURUTA Keiko, IMAI Yohsuke, UENO Hironori, MATSUKI Noriaki, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2012, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2012(0) (0), _8F25 - 1_-_8F25-2_, Japanese

  [Refereed]

  International conference proceedings


• 7E41 Development of a micro fluidic device to separate motile bacteria

  SHIOIRI Tatsuya, ISHIKAWA Takuji, NUMAYAMA Keiko, UENO Hironori, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2012, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2012(0) (0), _7E41 - 1_-_7E41-2_, Japanese

  International conference proceedings


• DYNAMICS OF A SPHERICAL CAPSULE IN A NEAR-WALL SHEAR FLOW

  Stephanie Nix, Yohsuke Imai, Daiki Matsunaga, Takuji Ishikawa, Takami Yamaguchi

  2012, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, CD-ROM, 839 - 840, English

  [Refereed]

  International conference proceedings


• DOUBLE-LAYER REPRESENTATION OF MODEL MICROORGANISMS BY A BOUNDARY ELEMENT METHOD

  Kohei Kyoya, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa

  2012, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, CD-ROM, 777 - 778, English

  [Refereed]

  International conference proceedings


• DEVELOPMENT OF A NUMERICAL MODEL FOR MICRO-SCALE BLOOD FLOW SIMULATION USING GPGPU

  Naoki Takeishi, Yohsuke Imai, Keita Nakaaki, Takuji Ishikawa, Takami Yamaguchi

  2012, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, CD-ROM, 823 - 824, English

  [Refereed]

  International conference proceedings


• DEVELOPMENT OF A MULTI-PHASE FLOW MODEL FOR SIMULATING SOLID PARTICLE MOTION IN THE STOMACH

  Taimei Miyagawa, Yohsuke Imai, Ikuma Kobayashi, Takuji Ishikawa, Takami Yamaguchi

  2012, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B, CD-ROM, 787 - 788, English

  [Refereed]

  International conference proceedings


• Boundary element analysis of the multi-capsule flow using an ultra-high speed GPGPU computation

  D. Matsunaga, Y. Imai, T. Ishikawa, T. Yamaguchi

  2012, BOUNDARY ELEMENTS AND OTHER MESH REDUCTION METHODS XXXIV, 53, 201 - 208, English

  [Refereed]

  International conference proceedings


• Boundary element analysis of deformation and movement of a capsule and a red blood cell close to the wall

  S. Nix, Y. Imai, T. Ishikawa, T. Yamaguchi

  2012, BOUNDARY ELEMENTS AND OTHER MESH REDUCTION METHODS XXXIV, 53, 191 - 199, English

  [Refereed]

  International conference proceedings


• Patient-specific modelling of pulmonary airflow using GPU cluster for the application in medical practice

  T. Miki, X. Wang, T. Aoki, Y. Imai, T. Ishikawa, K. Takase, T. Yamaguchi

  2012, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 15(7) (7), 771 - 778, English

  [Refereed]

  Scientific journal


• Separation of cancer cells from a red blood cell suspension using inertial force

  Tatsuya Tanaka, Takuji Ishikawa, Keiko Numayama-Tsuruta, Yohsuke Imai, Hironori Ueno, Noriaki Matsuki, Takami Yamaguchi

  2012, LAB ON A CHIP, 12(21) (21), 4336 - 4343, English

  [Refereed]

  Scientific journal


• Multi-GPU computing of capsule flow using boundary integral method

  D. Matsunaga, Y. Imai, T. Omori, T. Ishikawa, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 72 - 73, English

  International conference proceedings


• GPU-based simulation of blood flow in complex microvessels

  K. Nakaaki, Y. Imai, T. Ishikawa, C. T. Lim, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 152 - 153, English

  International conference proceedings


• Entrapment of fresh water ciliates at the interface fluid-air

  J. Ferracci, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 120 - 121, English

  International conference proceedings


• Computation of near-wall capsule flow using boundary integral method

  S. Nix, Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 76 - 77, English

  International conference proceedings


• Collective diffusion of red blood cells from high concentration to low

  C. Chuang, T. Ishikawa, H. Ueno, K. Numayama-Tsuruta, Y. Imai, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 32 - 33, English

  International conference proceedings


• Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation

  Vladimir Leble, Rui Lima, Ricardo Dias, Carla Fernandes, Takuji Ishikawa, Yohsuke Imai, Takami Yamaguchi

  Dec. 2011, BIOMICROFLUIDICS, 5(4) (4), 044120, English

  [Refereed]

  Scientific journal


• A numerical computation on gastric mixing using GPU

  I. Kobayashi, Y. Imai, S. Ishida, T. Ishikawa, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 150 - 151, English

  International conference proceedings


• Analysis of fluid flow on the surface of tracheal lumen through effective ciliary motion

  K. Kiyota, H. Ueno, T. Ishikawa, K. Numayama-Tsuruta, Y. Imai, N. Matsuki, T. Yamaguchi

  Dec. 2011, 5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 34 - 35, English

  International conference proceedings


• Energy transport in a concentrated suspension of bacteria

  T. Ishikawa, N. Yoshida, H. Ueno, M. Wiedeman, Y. Imai, T. Yamaguchi

  Nov. 2011, Bulletin of the American Physical Society, DFD2011, 56, 388, English

  International conference proceedings


• Development of GPU computing for simulating dense suspension of capsules

  Y. Imai, D. Matsunaga, T. Ishikawa, T. Yamaguchi

  Nov. 2011, 5th Shanghai Int. Conf. Biophysics and Molecular Biology Abstract Book, 125, English

  International conference proceedings


• Swallowing simulation based on videofluorography

  S. Ishida, Y. Imai, T. Ishikawa, A. Kinjyo, N. Matsuki, T. Yamaguchi

  Sep. 2011, The International Conference on BioTribology Conference Abstracts, CD-ROM, English

  International conference proceedings


• Modelling of red blood cell motion and deformation using particle based method

  T. Yamaguchi, Y. Imai, T. Ishikawa

  Sep. 2011, Proc. ECCOMAS SIMBIO 2011, CD-ROM, English

  International conference proceedings


• Particle based modeling and simulation of the red blood cell infected by malaria -mechanism of the margination of the infected red blood cell

  T. Yamaguchi, T. Ishikawa, Y. Imai

  Aug. 2011, 3rd Micro and Nano Flows Conference, CD-ROM, English

  International conference proceedings


• Energy Transport in a Concentrated Suspension of Bacteria

  T. Ishikawa, N. Yoshida, H. Ueno, M. Wiedeman, Y. Imai, T. Yamaguchi

  Jul. 2011, PHYSICAL REVIEW LETTERS, 107(2) (2), 028102, English

  [Refereed]

  Scientific journal


• Transport phenomena of microbial flora in the small intestine with peristalsis

  T. Ishikawa, T. Sato, G. Mohit, Y. Imai, T. Yamaguchi

  Jun. 2011, JOURNAL OF THEORETICAL BIOLOGY, 279(1) (1), 63 - 73, English

  [Refereed]

  Scientific journal


• Numerical simulation on margination of malaria-infected red blood cells in microvessels

  Y.Imai, K.Nakaaki, T.Ishikawa, T.Yamaguchi

  Jun. 2011, Proc Japan-Portugal Nano-BME Symp, 7 - 10, English

  International conference proceedings


• Numerical simulation of cell depleted peripheral layer and red blood cells motion in microvascular blood flow

  D.Alizadehrad, Y.Imai, T.Ishikawa, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 15 - 16, English

  International conference proceedings


• Motions of trace particles and red blood cells in a PDMS microchannel with a converging bifurcation

  V.Leble, R.Dias, R.Lima, C.Fernandes, T.Ishikawa, Y.Imai, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 29 - 30, English

  International conference proceedings


• High performance GPU computing of capsule flow using boundary integral method

  D.Matsunaga, Y.Imai, T.Omori, T.Miki, T.Ishikawa, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 19 - 22, English

  International conference proceedings


• Gradient diffusion of red blood cells in a Y-shape microchannel

  C.-H.Chuang, T.Ishikawa, K.Numayama-Tsuruta, Y.Imai, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 17 - 18, English

  International conference proceedings


• Development of a microfluidic device for partial cell separation

  R.Lima, M.S.N.Oliveira, T.Yaginuma, T.Ishikawa, Y.Imai, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 49 - 50, English

  International conference proceedings


• Computational biomechanics for respiratory and micro-circulation systems

  T.Yamaguchi, T.Ishikawa, Y.Imai

  Jun. 2011, Proc Japan-Portugal Nano-BME Symp, 1 - 4, English

  International conference proceedings


• Analysis of ciliary motion and fluid flow on the surface of tracheal cells

  H.Ueno, T.Ishikawa, K.Gonda, K.H.Bui, T.Ishikawa, Y.Imai, K.Numayama-Tsuruta, T.Yamaguchi

  Jun. 2011, Proc. Japan-Portugal Nano-BME Symp, 11 - 14, English

  International conference proceedings


• Computational analysis of the margination of malaria-infected red blood cells in microcirculation

  T. Yamaguchi, T. Ishikawa, Y. Imai

  May 2011, Microscale Modeling in Biomechanics and Mechanobiology Program and Abstract, English

  International conference proceedings


• Effect of red blood cells on dynamics of microvascular blood flow

  D. Alizadehrad, Y. Imai, T. Ishikawa, T. Yamaguchi

  May 2011, Microscale Modeling in Biomechanics and Mechanobiology Program and Abstract, English

  International conference proceedings


• Capsule flow analysis using GPU computation

  D. Matsunaga, Y. Imai, T. Omori, T. Miki, T. Ishikawa, T. Yamaguchi

  May 2011, Microscale Modeling in Biomechanics and Mechanobiology Program and Abstract, English

  International conference proceedings


• Diffusion of red blood cells from high concentration to low in a blood flow microchannel

  C. Chugang, T. Ishikawa, K. Numayama, Y. Imai, H. Ueno, T. Yamaguchi

  May 2011, Microscale Modeling in Biomechanics and Mechanobiology Program and Abstract, English

  International conference proceedings


• Margination of red blood cells infected by Plasmodium falciparum in a microvessel

  Yohsuke Imai, Keita Nakaaki, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi

  May 2011, JOURNAL OF BIOMECHANICS, 44(8) (8), 1553 - 1558, English

  [Refereed]

  Scientific journal


• Comparison between spring network models and continuum constitutive laws: Application to the large deformation of a capsule in shear flow

  T. Omori, T. Ishikawa, D. Barthes-Biesel, A. -V. Salsac, J. Walter, Y. Imai, T. Yamaguchi

  Apr. 2011, PHYSICAL REVIEW E, 83(4) (4), 041918, English

  [Refereed]

  Scientific journal


• Novel methods for the computational biomechanics study of respiratory and micro-circulatory systems

  T. Yamaguchi, T. Ishikawa, Y. Imai

  Mar. 2011, 16th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 99 - 102, English

  International conference proceedings


• A fourth-order Cartesian local mesh refinement method for the computational fluid dynamics of physiological flow in multi-generation branched vessels

  Takahito Miki, Yohsuke Imai, Takuji Ishikawa, Shigeo Wada, Takayuki Aoki, Takami Yamaguchi

  Mar. 2011, INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, 27(3) (3), 424 - 435, English

  [Refereed]

  Scientific journal


• Asymmetry of blood flow and cancer cell adhesion in a microchannel with symmetric bifurcation and confluence

  Takuji Ishikawa, Hiroki Fujiwara, Noriaki Matsuki, Takefumi Yoshimoto, Yohsuke Imai, Hironori Ueno, Takami Yamaguchi

  Feb. 2011, BIOMEDICAL MICRODEVICES, 13(1) (1), 159 - 167, English

  [Refereed]

  Scientific journal


• Particle based simulation of the microvascular blood flow in the malaria infection

  T. Yamaguchi, Y. Imai, T. Ishikawa

  2011, Trends & Challenges in Computational Mechanics Program and Abstracts, 43 - 44, English

  International conference proceedings


• Microscale Flow Dynamics of Red Blood Cells in Microchannels: An Experimental and Numerical Analysis

  R. Lima, C. S. Fernandes, R. Dias, T. Ishikawa, Y. Imai, T. Yamaguchi

  2011, COMPUTATIONAL VISION AND MEDICAL IMAGE PROCESSING: RECENT TRENDS, 19, 297 - 309, English

  International conference proceedings


• Fluid particle diffusion through high-hematocrit blood flow within a capillary tube

  Maryam Saadatmand, Takuji Ishikawa, Noriaki Matsuki, Mohammad Jafar Abdekhodaie, Yohsuke Imai, Hironori Ueno, Takami Yamaguchi

  Jan. 2011, JOURNAL OF BIOMECHANICS, 44(1) (1), 170 - 175, English

  [Refereed]

  Scientific journal


• Development of a microdevice for sorting motile bacteria

  T. Shioiri, T. Ishikawa, K. Numayama-Tsuruta, Y. Imai, H. Ueno, T. Yamaguchi

  2011, ASME 2011 6th Frontiers in Biomedical Devices Conference and Exhibition, BioMed 2011, CD-ROM, 25 - 26, English

  [Refereed]

  International conference proceedings


• Collection of cancer cells from blood samples using inertial migration forces

  T. Tanaka, T. Ishikawa, K. Numayama-Tsuruta, Y. Imai, H. Ueno, N. Matsuki, T. Yamaguchi

  2011, ASME 2011 6th Frontiers in Biomedical Devices Conference and Exhibition, BioMed 2011, CD-ROM, 13 - 14, English

  [Refereed]

  International conference proceedings


• B113 Gradient Diffusion of Red Blood Cells Flowing in a Straight Micro-channel

  HUANG Cheng-Hsi, ISHIKAWA Takuji, UENO Hironori, NUMAYAMA Keiko, IMAI Yohsuke, YAMAGUCHI Takami

  We investigated the gradient diffusion of red blood cells (RBCs) in blood flow in a microchannel. The effects of flow rates, and hematocrit (Hct) on the gradient diffusion were investigated experimentally. Under the same hematocrit condition, the gradient dispersion coefficient was increased almost linearly to the flow rate. The gradient diffusion dominated over Brownian diffusion in most of high hematocrit conditions. These findings provide useful information in understanding mass transport in small vessels.

  The Japan Society of Mechanical Engineers, 2011, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2011(0) (0), 63 - 64, English

  Research society


• Large-scale numerical simulation of blood flow in microvessels

  D.Alizadehrad, Y.Imai, T.Ishikawa, T.Yamaguchi

  Dec. 2010, Proc. 4th East Asian Pacific Stu. Workshop Nano-Biomed. Eng, 98 - 99, English

  International conference proceedings


• Designing a clinical education program for engineers: The ESTEEM Project

  Noriaki Matsuki, Motohiro Takeda, Masahiro Yamano, Yohsuke Imai, Takuji Ishikawa, Takami Yamaguchi

  Nov. 2010, JOURNAL OF INTERPROFESSIONAL CARE, 24(6) (6), 738 - 741, English

  [Refereed]

  Scientific journal


• Separation of cancer cells from blood by using a micro fluidic device

  T.Tanaka, T.Ishikawa, N.Matsuki, Y.Imai, H.Ueno, K.Numayama-Tsuruta, T.Yamaguchi

  Sep. 2010, KIST-Tohoku Joint Symp Nanobiomed Eng, 75 - 76, English

  International conference proceedings


• Effects of rosette formation and cytoadhesion on hemodynamics in malaria infection

  K.Nakaaki, Y.Imai, H.Kondo, T.Ishikawa, C.T.Lim, T.Yamaguchi

  Sep. 2010, KIST-Tohoku Joint Symp Nanobiomed Eng, 67 - 68, English

  International conference proceedings


• A numerical study on migration of malaria infected red blood cells

  Y.Imai, K.Nakaaki, H.Kondo, T.Ishikawa, C.T.Lim, T.Yamaguchi

  Sep. 2010, KIST-Tohoku Joint Symp Nanobiomed Eng, 15 - 16, English

  [Refereed][Invited]

  International conference proceedings


• Parallel 3-D Code to Investigate the Pathophysiology of Malaria on Distributed Memory Systems

  D.Alizadehrad, Y.Imai, T.Ishikawa, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 581, English

  International conference proceedings


• Micro-flow Visualization of in vitro Blood through a Microchannel with a Bifurcation and Confluence

  R.Lima, M.Oliveira, T.Ishikawa, N.Matsuki, Y.Imai, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 561, English

  International conference proceedings


• Measuring the Cell-Free Layer in circular Microchannels

  C.Fidalgo, A.Sa, R.Lima, M.Oliveira, T.Ishikawa, Y.Imai, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 472, English

  International conference proceedings


• Measurement of the red blood cell (RBC) dispersion in microchannels: the effect of the temperature

  D.Pinho, A.Pereira, R.Lima, T.Ishikawa, Y.Imai, T.Yamaguchi

  Aug. 2010, IFMBE Proceedings, 31, 1067 - 1070, English

  International conference proceedings


• Effect of Membrane Modeling on the Capsule Deformation: Comparison between a Spring Network and Continuum Models

  T.Omori, T.Ishikawa, D.Barthes-Biesel, A.-V.Salsac, Y.Imai, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 470, English

  International conference proceedings


• Effect of Adhesive Properties of Malaria-infected Red Blood Cells in Microcirculation

  K.Nakaaki, Y.Imai, H.Kondo, T.Ishikawa, C.T.Lim, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 503, English

  International conference proceedings


• Diffusion of Fluid Particles in High Hematocrit Blood Flow in a Capillary Tube

  M.Saadatmand, T.Ishikawa, N.Matsuki, M.J.Abdekhodaie, Y.Imai, H.Ueno, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 471, English

  International conference proceedings


• Development of a Micro Fluidic Device to Separate Cancer Cells from Blood

  T.Tanaka, T.Ishikawa, N.Matsuki, Y.Imai, H.Ueno, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 164, English

  International conference proceedings


• A Numerical Study on the Behavior of Cells in Micro-scale Blood Flows

  Y.Matsumoto, Y.Imai, T.Ishikawa, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 471, English

  International conference proceedings


• A Numerical Study on Fluid Motion in the Stomach

  I.Kobayashi, Y.Imai, S.Ishida, T.Ishikawa, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 575, English

  International conference proceedings


• Analysis of Swallowing Motion based on Videofluorography

  S.Ishida, Y.Imai, A.Kinjo, N.Matsuki, T.Ishikawa, T.Yamaguchi

  Aug. 2010, 6th World Congress of Biomechanics Abstracts, 165, English

  International conference proceedings


• Blood flow and cancer cell adhesion in a microchannel with bifurcation and confluence

  T.Ishikawa, H.Fujiwara, N.Matsuki, T.Yoshimoto, Y.Imai, H.Ueno, T.Yamaguchi

  Jul. 2010, ESB2010 Abstracts CD-ROM, English

  International conference proceedings


• Confocal micro-flow visualization of blood cells

  R. Lima, T. Ishikawa, Y. Imai, T. Yamaguchi

  Jun. 2010, CFD2010 Proceedings (CD-ROM), English

  International conference proceedings


• Efficient parallel code for simulating malaria infected blood flow

  D. Alizadehrad, Y. Imai, T. Ishikawa, T. Yamaguchi

  May 2010, 22nd International Conference on Parallel Computational Fluid Dynamics (ParCFD 2010) (CD-ROM), English

  International conference proceedings


• Numerical simulation of interaction among malaria-infected red blood cells, healthy red blood cells, and endothelial cells

  Y.Imai, K.Nakaaki, H.Kondo, T.Ishikawa, C.T.Lim, T.Yamaguchi

  May 2010, Proc. 4th ECCM, CD-ROM, No.269, English

  [Refereed][Invited]

  International conference proceedings


• Modeling of hemodynamics arising from malaria infection

  Yohsuke Imai, Hitoshi Kondo, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi

  May 2010, JOURNAL OF BIOMECHANICS, 43(7) (7), 1386 - 1393, English

  [Refereed]

  Scientific journal


• Impact of membrane modeling in analysing deformation of a capsule:comparison between a spring network model and constitutive laws

  T.Omori, T.Ishikawa, D.Barthes-biesel, A.V.Salsac, Y.Imai, T.Yamaguchi

  May 2010, Proc. 4th ECCM, No. 781, English

  [Refereed]

  International conference proceedings


• Activation of caspases and apoptosis in response to low-voltage electric pulses

  Noriaki Matsuki, Motohiro Takeda, Takuji Ishikawa, Aki Kinjo, Tomoaki Hayasaka, Yohsuke Imai, Takami Yamaguchi

  May 2010, ONCOLOGY REPORTS, 23(5) (5), 1425 - 1433, English

  [Refereed]

  Scientific journal


• Effect of pneumothorax on morphology and hemodynamic of pulmonary artery

  J-J. Christophe, T. Ishikawa, N. Matsuki, Y. Imai, K. Takase, M. Thiriet, T. Yamaguchi

  Mar. 2010, 11th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 103 - 104, English

  International conference proceedings


• Radial dispersion of tracer particles in blood flow in a capillary tube

  M. Saadatmand, T. Ishikawa, N. Matsuki, M. J. Abdekhodaie, Y. Imai, H. Ueno, T. Yamaguchi

  Mar. 2010, 11th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 113 - 114, English

  International conference proceedings


• Comprehensive application of particle methods to the diseases of the blood

  T. Yamaguchi, Y. Imai, H. Kamada, K. Nakaaki, T. Ishikawa

  Mar. 2010, The 2nd Biosupercomputing symposium, 118 - 119, English

  International conference proceedings


• Particle-Based Methods for Multiscale Modeling of Blood Flow in the Circulation and in Devices: Challenges and Future Directions

  Takami Yamaguchi, Takuji Ishikawa, Y. Imai, N. Matsuki, Mikhail Xenos, Yuefan Deng, Danny Bluestein

  Mar. 2010, ANNALS OF BIOMEDICAL ENGINEERING, 38(3) (3), 1225 - 1235, English

  [Refereed]

  Scientific journal


• ATP Transport in Saccular Cerebral Aneurysms at Arterial Bends

  Yohsuke Imai, Kodai Sato, Takuji Ishikawa, Andrew Comerford, Tim David, Takami Yamaguchi

  Mar. 2010, ANNALS OF BIOMEDICAL ENGINEERING, 38(3) (3), 927 - 934, English

  [Refereed]

  Scientific journal


• Computational biomechanics for investigating cardiovascular diseases

  T. Yamaguchi, H. Kondo, Y. Shimogonya, Y. Imai, N. Matsuki, T. Ishikawa

  Feb. 2010, Nano-Biomedical Engineering 2009, 41 - 50, English


• J0205-3-1 Three dimensional meso-scale flow structures in a suspension of E. coli

  Ishikawa T., Yoshida N., Ueno H., Matsuki N., Imai Y., Yamaguchi T.

  The Japan Society of Mechanical Engineers, 2010, The proceedings of the JSME annual meeting, 2010, 51 - 52, Japanese


• Red Blood Cell Dispersion in 100 mu m Glass Capillaries: The Temperature Effect

  D. Pinho, A. Pereira, R. Lima, T. Ishikawa, Y. Imai, T. Yamaguchi

  2010, 6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3, 31, 1067 - +, English

  [Refereed]

  International conference proceedings


• Particle method computation of the red blood cell motion in malaria infection

  Takami Yamaguchi, Yosuke Imai, Takuji Ishikawa

  2010, AIP Conference Proceedings, 1281, 591 - 593, English

  International conference proceedings


• Cellular behaviours in high hematocrit blood flow in micro-channels

  T.Ishikawa, N.Matsuki, Y.Imai, H.Ueno, T. Yamaguchi

  Jan. 2010, SMART-Tohoku GCOE joint Workshop on Micro & Nano Bioenginering, 50 - 50, English

  International conference proceedings


• Numerical Modeling of Microvascular Hemodynamics in Plasmodium Falciparum Malaria

  Y. Imai, K. Nakaaki, H. Kondo, T. Ishikawa, C. T. Lim, T. Yamaguchi

  2010, 6TH WORLD CONGRESS OF BIOMECHANICS (WCB 2010), PTS 1-3, 31, 1145 - +, English

  International conference proceedings


• Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung due to pneumothorax

  Jean-Joseph Christophe, Takuji Ishikawa, Noriaki Matsuki, Yohsuke Imai, Kei Takase, Marc Thiriet, Takami Yamaguchi

  2010, Journal of Biomechanical Science and Engineering, 5(5) (5), 485 - 498, English

  [Refereed]

  Scientific journal


• 【コンピュータを用いた呼吸器病態解析の進歩と展望】肺呼吸の計算力学シミュレーション

  和田 成生, 今井 陽介, 三木 貴仁, 石川 顕一, 鈴木 慎悟, 中村 匡徳

  (株)医学書院, Dec. 2009, 呼吸と循環, 57(12) (12), 1219 - 1227, Japanese


• Patient specific morphological and hemodynamic analysis of pulmonary artery in the case of severe deformations of the lung

  J-J.Christophe, T.Ishikawa, N.Matsuki, Y.Imai, K.Takase, M.Thiriet, T.Yamaguchi

  Dec. 2009, 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 124 - 125, English

  International conference proceedings


• Impact of membrane modeling on the deformation analysis of a capsule

  T.Omori, T.Ishikawa, D.Barthes-Biesel, A.V.Salsac, Y.Imai, T.Yamaguchi

  Dec. 2009, 3rd East Asian Pacific Student Workshop on Nano-Biomedical Engineering, 122 - 123, English

  International conference proceedings


• Development of a biologically inspired locomotion system for a capsule endoscope

  Daisuke Hosokawa, Takuji Ishikawa, Hirohisa Morikawa, Yohsuke Imai, Takami Yamaguchi

  Dec. 2009, INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, 5(4) (4), 471 - 478, English

  [Refereed]

  Scientific journal


• Fluid flow analysis of the surface of tracheal ciliary cells

  H. Ueno, K. Gonda, Y. Imai, N. Matsuki, T. Ishikawa, T. Yamaguchi

  Nov. 2009, Dynein International Workshop 2009, p.11, English


• Simulation of saccular cerebral aneurysm formation based on GON indicator

  Y. Shimogonya, T. Ishikawa, Y. Imai, N. Matsuki, T. Yamaguchi

  Nov. 2009, International Journal of Computational Fluid Dynamics, 23, 583 - 593, English

  [Refereed]

  Scientific journal


• Patient-specific blood flow analysis of pulmonary artery affected by severe deformations of the lung

  J-J.Christophe, T.Ishikawa, N.Matsuki, Y.Imai, K.Takase, M.Thiriet, T.Yamaguchi

  Nov. 2009, VIPIMAGE2009, Computational Vision and Medical Image Processing, 335 - 338, English

  [Refereed]

  International conference proceedings


• Motions of particles and red blood cells in a bifurcation: comparison between experiments and numerical simulations

  M.Lagoela, B.Oliveira, D.Cidre, C.Fernandes, C.Balsa, R.Lima, R.Dias, T.Ishikawa, Y.Imai, T. Yamaguchi

  Nov. 2009, VIPIMAGE2009, Computational Vision and Medical Image Processing, 339 - 342, English

  [Refereed]

  International conference proceedings


• Determination of the cell-free layer in circular PDMS microchannels

  T.Cerdeira, F.Monteiro, R.Lima, M.Oliveira, T.Ishikawa, Y.Imai, T.Yamaguchi

  Nov. 2009, VIPIMAGE2009, Computational Vision and Medical Image Processing, 357 - 360, English

  [Refereed]

  International conference proceedings


• Simulation of rosette formation and destruction of malaria infected red blood cells

  T.Yamaguchi, Y.Imai, T.Ishikawa

  Sep. 2009, Book of Abstracts BIOENGINEERING 09, 48 - 48, English

  International conference proceedings


• Pulmonary airflow simulation of inspiration and expiration using a patient-specific model

  T.Miki, Y.Imai, T.Ishikawa, T.Yamaguchi

  Sep. 2009, Book of Abstracts BIOENGINEERING 09, 92 - 92, English

  International conference proceedings


• On the sensitivity of a hemodynamic index for cerebral aneurysm initiation, the GON, to flow input waveform

  Y.Shimogonya, T.Ishikawa, Y.Imai, N.Matsuki, T.Yamaguchi

  Sep. 2009, Book of Abstracts BIOENGINEERING 09, 126 - 126, English

  International conference proceedings


• Mixing of red blood cells in high hematocrit blood flow in micro-channels

  T.Ishikawa, H.Fujiwara, R.Lima, N.Matsuki, Y.Imai, T.Yamaguchi

  Sep. 2009, Proc. 3rd Switzerland-Japan Workshop on Biomechanics 2009, 47 - 47, English

  International conference proceedings


• Measurement of Individual Red Blood Cell Motions Under High Hematocrit Conditions Using a Confocal Micro-PTV System

  Rui Lima, Takuji Ishikawa, Yohsuke Imai, Motohiro Takeda, Shigeo Wada, Takami Yamaguchi

  Aug. 2009, ANNALS OF BIOMEDICAL ENGINEERING, 37(8) (8), 1546 - 1559, English

  [Refereed]

  Scientific journal


• A particle based modeling and analysis of Malaria infected red blood cell in microcirculation

  T. Yamaguchi, H. Kondo, Y. Imai, N. Matsuki, H. Ueno

  Jul. 2009, 10th U.S. National Congress on Computational Mechanics Congress Program, 42 - 42, English

  International conference proceedings


• Computational biomechanics of malaria and arterial diseases

  T. Ishikawa, Y. Imai, T. Yamaguchi

  Jul. 2009, 36th International Congress of Physiological Sciences Final Program, 143 - 143, English

  International conference proceedings


• Development of an Ethernet-linked Wearable System for Monitoring EMG and Acceleration

  M. Kishimoto, T. Yoshida, T. Hayasaka, D. Mori, Y. Imai, N. Matsuki, T. Ishikawa, T. Yamaguchi

  Jul. 2009, Technology and Health Care, 17, 121 - 131, English

  [Refereed]

  Scientific journal


• Effects of unique biomedical education programs for engineers: REDEEM and ESTEEM projects

  Noriaki Matsuki, Motohiro Takeda, Masahiro Yamano, Yohsuke Imai, Takuji Ishikawa, Takami Yamaguchi

  Jun. 2009, ADVANCES IN PHYSIOLOGY EDUCATION, 33(2) (2), 91 - 97, English

  [Refereed]

  Scientific journal


• Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel

  H. Fujiwara, T. Ishikawa, R. Lima, N. Matsuki, Y. Imai, H. Kaji, M. Nishizawa, T. Yamaguchi

  May 2009, JOURNAL OF BIOMECHANICS, 42(7) (7), 838 - 843, English

  [Refereed]

  Scientific journal


• Numerical simulation of inspiratory and expiratory pulmonary airflow using a patient-specific model

  T. Miki, Y. Imai, T. Ishikawa, S. Wada, T. Yamaguchi

  Apr. 2009, 10th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network CentreNano-Biomedical Engineering in the East Asian-Pacific Rim Region Jointly Organised with Fourth Asian Pacific Conf, 20 - 21, English

  International conference proceedings


• Effect of the memberane bending stiffeness on the deformation of a red blood cell

  T. Oomori, T. Ishikawa, Dominique Barthes-Biesel, Y. Imai, T. Yamaguchi

  Apr. 2009, 10th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network CentreNano-Biomedical Engineering in the East Asian-Pacific Rim Region Jointly Organised with Fourth Asian Pacific Conf, 8 - 9, English

  International conference proceedings


• Patient-specific pulmonary airflow simulation using cartestian adaptive mesh refinement method

  T. Miki, Y. Imai, T. Ishikawa, S. Wada, T. Yamaguchi

  Apr. 2009, 15th Int. Conf. Finite Elements in Flow Problems (FEF09) Abstracts, 37, English

  International conference proceedings


• Numerical simulation of inpiratory and expiratory pulmonary airflow using a patient-specific model

  T. Miki, Y. Imai, T. Ishikawa, S. Wada, T. Yamaguchi

  Apr. 2009, Proc. AP Biomech 2009, 164 - 165, English

  International conference proceedings


• Motion of individual red blood cells in a concentrated suspension flowing through micro-channels

  T. Ishikawa, H. Fujiwara, N. Matsuki, R. Lima, Y. Imai, T. Yamaguchi

  Apr. 2009, Proc. AP Biomech 2009, 102 - 103, English

  International conference proceedings


• Motion of individual cells in high hematocrit blood flow in micro-channels

  T. Ishikawa, H. Fujiwara, N. Matsuki, R. Lima, Y. Imai, T. Yamaguchi

  Apr. 2009, Proc. ICCES'09, 244, English

  International conference proceedings


• Modeling of the membrane bending rigidity for calculating red blood cell deformation

  T. Omori, T. Ishikawa, D. Birthes-Biesel, Y. Imai, T. Yamaguchi

  Apr. 2009, 15th Int. Conf. Finite Elements in Flow Problems (FEF09) Abstracts, 41, English

  International conference proceedings


• Low voltage pulses can induce apoptosis

  N. Matsuki, T. Ishikawa, Y. Imai, T. Yamaguchi

  Apr. 2009, Proc. AP Biomech 2009, 154 - 155, English

  International conference proceedings


• Hemodynamic Analysis of Microcirculation in Malaria Infection

  Hitoshi Kondo, Yohsuke Imai, Takuji Ishikawa, Ken-ichi Tsubota, Takami Yamaguchi

  Apr. 2009, ANNALS OF BIOMEDICAL ENGINEERING, 37(4) (4), 702 - 709, English

  [Refereed]

  Scientific journal


• Effect of the membrane bending stiffness on the deformation of a red blood cell

  T. Omori, T. Ishikawa, D. Birthes-Biesel, Y. Imai, T. Yamaguchi

  Apr. 2009, Proc. AP Biomech, 196 - 197, English

  International conference proceedings


• Computational biomechanics for investigating various diseases over micro to macro scales

  T. Yamaguchi, T. Ishikawa, Y. Imai

  Apr. 2009, Proc. ICCES'09, 10, English

  [Invited]

  International conference proceedings


• A numerical model to study hemodynamics arising from malaria infection

  Y. Imai, H. Kondo, Y. H. Kang, T. Ishikawa, C. T. Lim, T. Yamaguchi

  Apr. 2009, Proc. ICCES'09, 96, English

  [Invited]

  International conference proceedings


• A micro scale blood flow model to study pathology of malaria

  Y. Imai, H. Kondo, Y. H. Kang, T. Ishikawa, C. T. Lim, T. Yamaguchi

  Apr. 2009, Proc. AP Biomech 2009, 100 - 101, English

  International conference proceedings


• Computational simulation of blood flow in pulmonary artery under respiratory disorders

  J-J. Christophe, T. Ishikawa, Y. Imai, N. Matsuki, K. Takase, T. Yamaguchi

  Mar. 2009, 9th International Symposium of Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region, 100 - 101, English

  International conference proceedings


• Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON)

  Yuji Shimogonya, Takuji Ishikawa, Yohsuke Imai, Noriaki Matsuki, Takami Yamaguchi

  Mar. 2009, JOURNAL OF BIOMECHANICS, 42(4) (4), 550 - 554, English

  [Refereed]

  Scientific journal


• Three-dimensional Simulation of Blood Flow in Malaria Infection

  Yohsuke Imai, H. Kondo, T. Ishikawa, C. T. Lim, K. Tsubota, T. Yamaguchi

  2009, IFMBE Proceedings, 23, 2244 - 2247, English

  [Refereed]

  International conference proceedings


• Simulation of microcirculatory disorder by malaria infection using a particle method

  T.Yamaguchi, H.Kondo, Y.Imai, T.Ishikawa

  2009, ICCB 2009, USB, 83, English

  International conference proceedings


• Particle method simulation of red blood cells infected by malaria

  T.Yamaguchi, Y.H.Kang, H.Kondo, Y.Imai, T.Ishikawa

  2009, Med. Phys. Biomed. Eng. World Cong. 2009, CD-ROM, 131, English

  International conference proceedings


• Microvascular disorders induced by malaria infected red blood cells: a computational mechanical study using the biological particle method

  T. Yamaguchi, H. Kondo, Y. Imai, T. Ishikawa

  2009, MODELLING IN MEDICINE AND BIOLOGY VIII, 13, 49 - +, English

  International conference proceedings


• RHEOLOGY OF CANCER CELLS WITH DIFFERENT METASTATIC PROPERTIES

  T. Yoshimoto, T. Ishikawa, N. Matsuki, H. Fujiwara, Y. Imai, H. Ueno, M. Takeda, T. Yamaguchi

  2009, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B, CD-ROM, 765 - 766, English

  [Refereed]

  International conference proceedings


• MORPHOLOGY AND BLOOD FLOW ANALYSIS OF PULMONARY ARTERIES UNDER RESPIRATORY DISORDERS

  Jean-Joseph Christophe, Takuji Ishikawa, Yohsuke Imai, Noriaki Matsuki, Kei Takase, Takami Yamaguchi

  2009, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B, CD-ROM, 1037 - 1038, English

  [Refereed]

  International conference proceedings


• INDIVIDUAL MOTIONS OF RED BLOOD CELLS IN HIGH-HEMATOCRIT BLOOD FLOWING IN A MICROCHANNEL WITH COMPLEX GEOMETRIES

  T. Ishikawa, H. Fujiwara, N. Matsuki, R. Lima, Y. Imai, H. Ueno, T. Yamaguchi

  2009, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B, CD-ROM, 443 - 444, English

  [Refereed]

  International conference proceedings


• CLINICAL EDUCATION FOR ENGINEERS: ESTEEM PROJECT

  N. Matsuki, M. Takede, M. Yamano, Y. Imai, T. Ishikawa, T. Yamaguchi

  2009, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B, CD-ROM, 479 - 480, English

  [Refereed]

  International conference proceedings


• A NUMERICAL MODEL OF ADHESION PROPERTY OF MALARIA INFECTED RED BLOOD CELLS IN MICRO SCALE BLOOD FLOWS

  Yohsuke Imai, Hitoshi Kondo, Young Ho Kang, Takuji Ishikawa, Chwee Teck Lim, Takami Yamaguchi

  2009, PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE - 2009, PT A AND B, CD-ROM, 331 - 332, English

  [Refereed]

  International conference proceedings


• An internet-based wearable watch-over system for elderly and disabled utilizing EMG and accelerometer

  M. Kishimoto, T. Yoshida, T. Hayasaka, D. Mori, Y. Imai, N. Matsuki, T. Ishikawa, T. Yamaguchi

  2009, Technology and Health Care, 17(2) (2), 121 - 131, English

  [Refereed]

  Scientific journal


• A realistic simulation of saccular cerebral aneurysm formation: focussing on a novel haemodynamic index, the gradient oscillatory number

  Y. Shimogonya, T. Ishikawa, Y. Imai, N. Matsuki, T. Yamaguchi

  2009, INTERNATIONAL JOURNAL OF COMPUTATIONAL FLUID DYNAMICS, 23(8) (8), 583 - 593, English

  [Refereed]

  Scientific journal


• Behavior of a red blood cell in a simple shear flow simulated by a boundary element method

  T. Omori, T. Ishikawa, D. Barthes-Biesel, Y. Imai, T. Yamaguchi

  Dec. 2008, GPBE/NUS-Tohoku Graduate Student Conf. Bioeng., Program & Abstract, 99 - 100, English


• A novel hemodynamic index for the initiation of cerebral aneurysms: focusing on temporal variation of spatial wall shear stress gradient

  Y. Shimogonya, T. Ishikawa, Y. Imai, N. Matsuki, T. Yamaguchi

  Dec. 2008, GPBE/NUS-Tohoku Graduate Student Conf. Bioeng., Program & Abstract, 95 - 96, English


• Numerical simulation of inspiratory and expiratory pulmonary airflow using a subject-specific model

  T. Miki, Y. Imai, T. Ishikawa, S. Wada, T. Yamaguchi

  Dec. 2008, GPBE/NUS-Tohoku Graduate Student Conf. Bioeng., Program & Abstract, 81 - 82, English


• Development of automatic respiration monitoring for home-care patients of respiratory diseases with therapeutic aids

  M. Okubo, Y. Imai, T. Ishikawa, T. Hayasaka, S. Ueno, T. Yamaguchi

  Nov. 2008, Int. Feder. Med. Biol. Eng. (IFMBE) Proc. (CD-ROM), 205, English


• Development of a mobile toilet system servicing elderly on call

  S. Ueno, T. Hayasaka, Y. Imai, M. Okubo, T. Ishikawa, T. Yamaguchi

  Nov. 2008, Int. Feder. Med. Biol. Eng. (IFMBE) Proc. (CD-ROM), 234, English


• A locomotive system mimicking pedal locomotion of snails for the capsule endoscope

  D. Hosokawa, T. Ishikawa, H. Morikawa, Y. Imai, T. Yamaguchi

  Nov. 2008, Int. Feder. Med. Biol. Eng. (IFMBE) Proc. (CD-ROM), 274, English


• Development of a Wearable System Module for Monitoring Physical and Mental Workload

  Sinbae Kim, Hiromi Nakamura, Toshihiko Yoshida, Masamichi Kishimoto, Yohsuke Imai, Noriaki Matsuki, Takuji Ishikawa, Takami Yamaguchi

  Nov. 2008, TELEMEDICINE JOURNAL AND E-HEALTH, 14(9) (9), 939 - 945, English

  [Refereed]

  Scientific journal


• Three-dimensional simulation of malaria-infected blood

  H. Kondo, Y. Imai, T. Ishikawa, K. Tsubota, C.T. Lim, T. Yamaguchi

  Oct. 2008, Interntional Symposium on Nano-Biomedical Engineering7th Intrnational Symposium of 2007 Tohoku University Global COE Program "Global Nano-Biomedical Engineering Education and Research Network Centre"Nano-Biomedical Engineering in the East Asian-Pacific Ri, 42 - 43, English

  International conference proceedings


• Behavior of a red blood cell in a simple shear flow simulated by a boundary element method

  T. Omori, T. Ishikawa, D. Barthes-Biesel, Y. Imai, T. Yamaguchi

  Sep. 2008, Book of Abstracts BIOENGINEERING 08, 135 - 135, English

  International conference proceedings


• Mixing of red blood cells in a micro-channel flow under high hematocrit conditions

  T. Ishikawa, R. Lima, H. Fujiwara, Y. Imai, N. Matsuki, T. Yamaguchi

  Sep. 2008, Bioengineering 08 Book of Abstracts, 61, English


• Confocal micro-PTV Measurements of Blood Flow in a Circular PDMS Microchannel

  R. Lima, T. Ishikawa, H. Kaji, Y. Imai, S. Wada, M. Nishizawa, T. Yamaguchi

  Sep. 2008, Bioengineering 08 Book of Abstracts, 166, English


• Proposal of a New Hemodynamic Index for Cerebral Aneurysm Initiation: Focusing on Temporal Fluctuation of Spatial Wall Shear Stress Gradient

  Y. Shimogonya, T. Ishikawa, Y. Imai, N. Matsuki, T. Yamaguchi

  Sep. 2008, Bioengineering 08 Book of Abstracts, 146, English


• Low voltage pulses can induce apoptosis

  Noriaki Matsuki, Takuji Ishikawa, Yousuke Imai, Takami Yamaguchi

  Sep. 2008, CANCER LETTERS, 269(1) (1), 93 - 100, English

  [Refereed]

  Scientific journal


• Inflow into saccular cerebral aneurysms at arterial bends

  Yohsuke Imai, Kodai Sato, Takuji Ishikawa, Takami Yamaguchi

  Sep. 2008, ANNALS OF BIOMEDICAL ENGINEERING, 36(9) (9), 1489 - 1495, English

  [Refereed]

  Scientific journal


• A numerical method for simulating micro-scale blood flow in malaria infection

  Y. Imai, H. Kondo, T. Ishikawa, K. Tsubota, C. T. Lim, T. Yamaguchi

  Sep. 2008, Abstracts of Bioengineering 08, English

  [Refereed]

  International conference proceedings


• Image-based pulmonary airflow simulation using cartesian adaptive mesh refinement method

  T. Miki, Y. Imai, M. Nakamura, C. Iwamura, T. Ishikawa, S. Wada, T. Yamaguchi

  Jul. 2008, 8th World Congress on Computational Mechanics (WCCM8) / 5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008) (PROGRAMME, CD-ROM), 216 - 216, English

  [Refereed]

  International conference proceedings


• Role of the hematocrit on the radial dispresion of red blood cells in glass capillaries

  R. Lima, T. Ishikawa, Y. Imai, M. Takeda, S. Wada, T. Yamaguchi

  Jul. 2008, ・16th Congress of the European Society of Biomechanics Conference Program ・Abstract 16th Congress of the European Society of Biomechanics (CD-ROM), 30 - 30, English

  International conference proceedings


• Three-Dimensional Simulation of Blood Flow arising from Malaria Infection

  H. Kondo, Y. Imai, T. Ishikawa, K. Tsubota, C. T. Lim, T. Yamaguchi

  Jul. 2008, IACM/ECCOMAS Congress 2008 CD-ROM, MS194C, English


• Motion of red blood cells and cell free layer distribution in a stenosed microchannel

  H.Fujiwara, T. Ishikawa, R. Lima, Y. Imai, N. Matsuki, D. Mori, T. Yamaguchi

  Jul. 2008, Journal of Biomechanics, 41, S390, English

  International conference proceedings


• Determination of blood cells motions and interactions by a confocal micro-PTV system

  R. Lima, T. Ishikawa, Y. Imai, M. Takeda, S. Wada, T. Yamaguchi

  Jul. 2008, Journal of Biomechanics, 41, S429, English

  International conference proceedings


• A numerical model of blood flow with malariainfected red blood cells

  Y. Imai, H. Kondo, T. Ishikawa, K. Tsubota, T. Yamaguchi

  Jul. 2008, Journal of Biomechanics, 41, S480, English

  International conference proceedings


• The importance of parent artery geometry in intra-aneurysmal hemodynamics

  Kodai Sato, Yohsuke Imai, Takuji Ishikawa, Noriaki Matsuki, Takami Yamaguchi

  Jul. 2008, MEDICAL ENGINEERING & PHYSICS, 30(6) (6), 774 - 782, English

  [Refereed]

  Scientific journal


• Radial dispersion of red blood cells in blood flowing through glass capillaries: The role of hematocrit and geometry

  Rui Lima, Takuji Ishikawa, Yohsuke Imai, Motohiro Takeda, Shigeo Wada, Takami Yamaguchi

  Jul. 2008, JOURNAL OF BIOMECHANICS, 41(10) (10), 2188 - 2196, English

  [Refereed]

  Scientific journal


• Multi-scale multi-physics simulations of Biological flows

  T. Yamaguchi, T. Miki, Y. Shimogonya, H. Kondo, D. Mori, Y. Imai, M. Nakamura, C. Iwamura, S. Wada, T. Ishikawa

  Jun. 2008, Int. Symp. Multi-scale Sim. Biol. Soft Mater. (MSBSM2008) Book of Abstracts, 2 - 3, English


• The importance of proliferation of the arterial wall in formation of saccular cerebral aneurysms

  Y. Shimogonya, T. Ishikawa, Y. Imai, D. Mori, T. Yamaguchi

  Jun. 2008, Proc. ASME 2008 Summer Bioeng. Conf.CD-ROM, English


• Pulmonary airflow simulation using subject-specific model and Cartesian adaptive mesh refinement method

  T. Miki, Y. Imai, S. Wada, T. Ishikawa, T. Yamaguchi

  May 2008, Proc. Tohoku-NUS Student Joint Symp, 16 - 17, English


• In vitro blood flow in a rectangular PDMS microchannel: experimental observations using a confocal micro-PIV system

  Rui Lima, Shigeo Wada, Shuji Tanaka, Motohiro Takeda, Takuji Ishikawa, Ken-ichi Tsubota, Yohsuke Imai, Takami Yamaguchi

  Apr. 2008, BIOMEDICAL MICRODEVICES, 10(2) (2), 153 - 167, English

  [Refereed]

  Scientific journal


• CT image-based pulmonary airflow simulation using airway scale determined mesh

  T. Miki, Y. Imai, M. Nakamura, C. Iwamura, T. Ishikawa, S. Wada, T. Yamaguchi

  Mar. 2008, Fifth International Bio-Fluid Symposium and Workshop, 146 - 147, English


• Some uninvestigated directions of computational fluid dynamics studies for flow

  T. Yamaguchi, T. Miki, Y. Shimogonya, H. Kondo, D. Mori, Y. Imai, M. Nakamura, C. Iwamura, S. Wada, T. Ishikawa

  Mar. 2008, Fifth International Bio-Fluid Symposium and Workshop, 65 - 66, English


• Conservative form of interpolated differential operator scheme for compressible and incompressible fluid dynamics

  Imai, Yohsuke, Aoki, Takayuki, Takizawa, Kenji

  Feb. 2008, JOURNAL OF COMPUTATIONAL PHYSICS, 227(4) (4), 2263 - 2285, English

  [Refereed]

  Scientific journal


• 708 Proposal of a new hemodynamic indicator for the initiation of cerebral aneurysms

  SHIMOGONYA Yuji, ISHIKAWA Takuji, IMAI Yohsuke, MORI Daisuke, YAMAGUCHI Takami

  We proposed a new hemodynamic indicator for the initiation of cerebral aneurysms, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We calculated the proposed hemodynamic indicator and other three hemodynamic quantities (time-averaged wall shear stress (WSS), time-averaged spatial WSS gradient (SWSSG), and potential aneurysm formation indicator (AFI)) for a patient-specific geometry before aneurysm formation by means of computational fluid dynamics technique. The results showed that only the proposed hemodynamic indicator had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed indicator might be a prospective hemodynamic indicator for the initiation of cerebral aneurysms.

  The Japan Society of Mechanical Engineers, 2008, The proceedings of the JSME annual meeting, 2008, 31 - 32, Japanese


• 832 Pulmonary airflow simulation using image-based airway model : comparison between inspiraotry and expiratory airflow pattern

  MIKI Takahito, IMAI Yohsuke, WADA Shigeo, ISHIKAWA Takuji, YAMAGUCHI Takami

  We have numerically analyzed inspiratory and expiratory airflow using an image-based pulmonary airway model. As a result, the image-based analysis provided us with some interesting flow features, which is hardly seen in analyses using idealistic airway models. We have examined relationship between flow rate at trachea and pressure drop between trachea and peripheral airways during inspiraotry and expiratory phase. There was difference of pressure drop between inspiratory and expiratory phase even the flow rate was identical, though pressure loss due to fluid viscosity in inspiratory and expiratory phase was almost identical. Generally, pressure drop in a tube is given from summation of dynamic pressure and pressure loss due to fluid viscosity. We conclude that the difference of pressure drop was occurred due to dynamic pressure caused by the difference of cross sectional area between trachea and peripheral airways.

  The Japan Society of Mechanical Engineers, 2008, The proceedings of the JSME annual meeting, 2008, 121 - 122, Japanese


• 722 A Thrust Mechanism Mimicking Pedal Locomotion of Gastropod

  HOSOKAWA Daisuke, MORIKAWA Hirohisa, ISHIKAWA Takuji, IMAI Yohsuke, MORI Daisuke, YAMAGUCHI Takami

  A capsule endoscope is recently developed for the observation of the digestive system because digestive diseases particularly cancers very frequently occur and became fatal. Despite many advantages, the capsule endoscope has some limitations in the diagnosis, since it only moves passively by the peristaltic motion of the intestine. In order to overcome this problem, locomotive functions are expected to the capsule endoscope. In this study, we report a mechanical crawler system mimicking the pedal locomotion of snails for such a capsule endoscope. The crawler we developed has four joints, five segments and two suction cups. In locomotion experiments on a horizontal plane and on an inclined plane of 10 degrees, we confirmed that the developed crawler could locomote at the speed of 3 mm/s.

  The Japan Society of Mechanical Engineers, 2008, The proceedings of the JSME annual meeting, 2008, 59 - 60, Japanese


• Microscale flow dynamics of red blood cells in a circular microchannel

  R. Lima, M. Nakamura, T. Ishikawa, S. Tanaka, M. Takeda, Y. Imai, K. Tsubota, S. Wada, T. Yamaguchi

  2008, COMPUTATIONAL VISION AND MEDICAL IMAGING PROCESSING, 53 - +, English

  [Refereed]

  International conference proceedings


• Formation of Saccular Cerebral Aneurysms May Require Proliferation of the Arterial Wall: Computational Investigation

  Yuji Shimogonya, Takuji Ishikawa, Yohsuke Imai, Daisuke Mori, Noriaki Matsuki, Takami Yamaguchi

  2008, Journal of Biomechanical Science and Engineering, 3(3) (3), 431 - 442, English

  [Refereed]

  Scientific journal


• Tracking of red blood cells in microchannel with stenosis by confocal micro PTV system

  H. Fujiwara, T. Ishikawa, R. Lima, Y. Imai, N. Matsuki, H. Kaji, D. Mori, M. Nishizawa, T. Yamaguchi

  Dec. 2007, Proc. 7th Int. Symp. Adv. Fluid Info. & 4th Int. Symp. Transdisciplinary Fluid Integr., 56 - 57, English

  [Refereed]


• Blood flow in microchannel with stenosis measured by a confocal micro PTV system

  H. Fujiwara, T. Ishikawa, R. Lima, Y. Imai, N. Matsuki, H. Kaji, D. Mori, M. Nishizawa, T. Yamaguchi

  Dec. 2007, Proc. 3rd Tohoku-NUS Joint Symp. Nano-Biomed. Eng. in the East Asian-Pacific Rim Region, 99 - 100, English

  [Refereed]


• Development of respiration measurement system with conductive rubber for elderly home care

  M. Okubo, M. Kishimoto, Y. Imai, T. Ishikawa, T. Yamaguchi

  Dec. 2007, Proc. 3rd Tohoku-NUS Joint Symp. Nano-Biomed. Eng. in the East Asian-Pacific Rim Region, 47 - 48, English

  [Refereed]


• Modeling of malaria-infected red blood cell mechanics using a particle method

  H. Kondo, Y. Imai, K. Tsubota, T. Ishikawa, T. Yamaguchi

  Dec. 2007, Proc. APCOM'07 in conjunction with EPMESC XI, CD-ROM MS22-4-2, English

  [Refereed]


• Numerical simulation of cerebral aneurysm growth based on a hemodynamic hypothesis

  Y. Shimogonya, T. Ishikawa, Y. Imai, T. Yamaguchi

  Dec. 2007, Proc. APCOM'07 in conjunction with EPMESC XI, CD-ROM MS22-3-3, English

  [Refereed]


• An AMR Method based on the IDO scheme for patient-specific pulmonary airflow simulation

  Y. Imai, T. Miki, T. Ishikawa, M. Nakamura, S. Wada, T. Yamaguchi

  Dec. 2007, Proc. APCOM'07 in conjunction with EPMESC XI, CD-ROM MS7-1-3, English

  [Refereed]


• Development of a wearable surveillance system using gait analysis

  Toshihiko Yoshida, Fumio Mizuno, Tomoaki Hayasaka, Kenichi Tsubota, Yousuke Imai, Takuji Ishikawa, Takami Yamaguchi

  Dec. 2007, TELEMEDICINE JOURNAL AND E-HEALTH, 13(6) (6), 703 - 713, English

  [Refereed]

  Scientific journal


• CT Image-Based Respiratory Flow Simulation by using Cartesian Adaptive Mesh Refinement Method

  T. Miki, Y. Imai, M. Nakamura, T. Ishikawa, S. Wada, T. Yamaguchi

  Nov. 2007, Proc. Int. Conf. Adaptive Modeling & Simulation, 166 - 169, English

  [Refereed]


• A Cartesian Adaptive Mesh Refinement Method for Simulating Physiological Flows

  Y. Imai, T. Miki, T. Aoki, M. Nakamura, T. Ishikawa, S. Wada, T. Yamaguchi

  Nov. 2007, Proc. Int. Conf. Adaptive Modeling & Simulation, 128 - 131, English

  [Refereed]


• The hydrodynamics of interactions between two swimming bacteria

  T. Ishikawa, G. Sekiya, Y. Imai, T. Yamaguchi

  Nov. 2007, Bulletin of the American Physical Society, 52, 245 - 246, English

  [Refereed]


• Numerical Simulation of Malaria-Infected Blood Flow using a Particle Method

  H. Kondo, Y. Imai, K. Tsubota, T. Ishikawa, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S226, English

  [Refereed]


• Measurement of Respiration by a Hyper Diaper with Conductive Rubber

  M. Okubo, M. Kishimoto, S. Kim, Y. Imai, T. Ishikawa, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S206, English

  [Refereed]


• Monitoring Physical and Mental Workloads by a Wearable Computer

  S. Kim, H. Nakamura, M. Kishimoto, Y. Imai, N. Matsuki, T. Ishikawa, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S103, English

  [Refereed]


• Measurement of Multi-Red Blood Cells Interactions in Blood Flow by Confocal Micro-PTV

  R. Lima, T. Ishikawa, H. Fujiwara, M. Takeda, Y. Imai, K. Tsubota, N. Matsuki, S. Wada, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S92, English

  [Refereed]


• Observation of the Blood Flow in Microchannel with Stenosis by Confocal-Micro-PIV

  H. Fujiwara, T. Ishikawa, R. Lima, H. Kaji, N. Matsuki, Y. Imai, M. Nishizawa, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S89, English

  [Refereed]


• Development of a Wearable System for Monitoring Health Condition

  M. Kishimoto, T. Yoshida, H. Nakamura, M. Okubo, Y. Suzuki, S. Kim, T. Hayasaka, Y. Imai, K. Tsubota, T. Ishikawa, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S84, English

  [Refereed]


• A Simulation Model for Cerebral Aneurysm Growth based on a Hemodynamic Hypothesis

  Y. Shimogonya, T. Ishikawa, Y. Imai, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S76, English

  [Refereed]


• CFD Study on Mass Transport to Saccular Aneurysms at Arterial Bend

  Y. Imai, K. Sato, T. Ishikawa, A. Comerford, T. David, T. Yamaguchi

  Nov. 2007, Proc. 3rd Asian Pacific Conf. Biomech., S58, English

  [Refereed]


• CFD modeling of pulmonary airflow using IDO-AMR method

  Y. Imai, T. Miki, S. Wada, M. Nakamura, T. Ishikawa, T. Yamaguchi

  Oct. 2007, Proc. 4th Japan-Taiwan Workshop on Mech. & Aerospace Eng., 289 - 294, English

  [Refereed]


• Hydrodynamic interactions between two swimming bacteria

  T. Ishikawa, G. Sekiya, Y. Imai, T. Yamaguchi

  Sep. 2007, BIOPHYSICAL JOURNAL, 93(6) (6), 2217 - 2225, English

  [Refereed]

  Scientific journal


• A fluid-solid interactions study of the pulse wave velocity in uniform arteries

  T. Fukui, Y. Imai, K. Tsubota, T. Ishikawa, S. Wada, T. Yamaguchi

  Jun. 2007, Biomechanics at micro- and nanoscale levels, World Scientific, 3, 146 - 156, English

  [Refereed]


• Measurement of erythrocyte motions in microchannels by using a confocal micro-PTV system

  R. Lima, T. Ishikawa, M. Takeda, S. Tanaka, Y. Imai, K. Tsubota, S. Wada, T. Yamaguchi

  Jun. 2007, Proc. 2007 Summer Bioengineering Conference, CD-ROM, 175969, English


• Wall shear stress change due to arterial wall stiffness; fluid-solid interaction study

  T. Fukui, K. H. Parker, Y. Imai, K. Tsubota, T. Ishikawa, S. Wada, T. Yamaguchi

  Jun. 2007, Proc. 2007 Summer Bioengineering Conference, CD-ROM, 176102, English


• Image-based simulation of pulmonary airflow using multi-level voxel modeling

  Y. Imai, T. Miki, M. Nakamura, T. Ishikawa, S. Wada, T. Yamaguchi

  Jun. 2007, Proc. 2007 Summer Bioengineering Conference, CD-ROM, 176529, English


• A simulation study on the growth of cerebral aneurysms

  Y. Shimogonya, Y. Imai, T. Ishikawa, T. Yamaguchi

  Jun. 2007, Proc. 2007 Summer Bioengineering Conference, CD-ROM, 176106, English


• Effects of arterial geometry on inflow rate into cerebral aneurysms on curved arteries

  Y. Imai, K. Sato, T. Ishikawa, T. Yamaguchi

  Jun. 2007, Proc. 2007 Summer Bioengineering Conference, CD-ROM, 176556, English


• Effect of the wall motion on arterial wall shear stress

  T. Fukui, K.H. Parker, Y. Imai, K. Tsubota, T. Ishikawa, S. Wada, T. Yamaguchi

  The distribution of wall shear stress (WSS) in arteries is affected by both blood and wall motion. Most studies have ignored wall motion by assuming that the artery wall is rigid. To investigate the influence of wall motion we have solved the coupled fluid-solid problem in a straight homogeneous tube. The inlet boundary condition of the tube was given as a pulse of velocity imposed at the inlet of the tube upon a steady flow of Reynolds number 1000. A commercial code (Radioss, Altair Engineering) was used to solve the fluid-solid interactions. Two kinds of waves are generated on the wall by the pulse imposed in the inlet flow; a wave of longitudinal motion of the wall (the longitudinal wave) and a wave of radial motion of the wall (the elastic wave). The ends of the vessel are assumed to be fixed which results in the reflection of both waves. The longitudinal wall motion reduces the relative speed of the blood, reducing WSS by up to 0.5 Pa. The largest effect of wall motion occurs when the longitudinal and elastic waves coincide, where the peak WSS is reduced by 1.0 Pa, which is a significant fraction of the observed WSS. Thus we can say that the effect of wall motion is important in considering physiological response of arterial wall to the blood flow.

  The Japan Society of Mechanical Engineers, May 2007, Journal of Biomechanical Science and Engineering, 2(2) (2), 58 - 68, English

  [Refereed]

  Scientific journal


• Comparison of efficient explicit schemes for shallow-water equations - Characteristics-based fractional-step method and multimoment Eulerian scheme

  Yohsuke Imai, Takayuki Aoki, Magdi Shoucri

  Mar. 2007, JOURNAL OF APPLIED METEOROLOGY AND CLIMATOLOGY, 46(3) (3), 388 - 395, English

  [Refereed]

  Scientific journal


• 64チャンネルマルチスライスCTを用いた肺気道形態の計測

  三木 貴仁, 中村 匡徳, 須田 祐司, 田村 弦, 今井 陽介, 石川 拓司, 山口 隆美, 和田 成生

  (一社)呼吸研究, Feb. 2007, 呼吸, 26(2Suppl.) (2Suppl.), S7 - S10, Japanese


• A Fluid-Solid Interaction Study of the Pulse Wave Velocity in Uniform Arteries

  T. Fukui, Kim. H. Parker, Y. Imai, K. Tsubota, T. Ishikawa, S. Wada, T. Yamaguchi

  Jan. 2007, Proc. Final Symp. Tohoku University 21st Century of Excellence Program, 919 - 927, English

  [Refereed]


• 1102 Image-based Simulation of Pulmonary Airflow

  MIKI Takahito, IMAI Yohsuke, NAKAMURA Masanori, ISHIKAWA Takuji, WADA Shigeo, YAMAGUCHI Takami

  We have developed a new method for respiratory computational fluid dynamics (CFD) simulation using realistic airway models extracted from multi-slice computed tomography (CT) images. Pulmonary airway is multi-scale tube, which is one of the difficulties in respiratory simulation. In the viewpoint of CFD, mesh size must be refined to capture airflow in the small airways. Therefore adaptive mesh refinement (AMR) method based on Interpolated Differential Operator (IDO) scheme is applied to respiratory simulation model. Mesh size is determined by the diameter of the airways in the local domain to maintain accuracy for CFD simulation and adjust computational time. As a result of CFD analysis, we have confirmed accuracy of our new AMR adopted airflow simulation in spite of the number of computational nodes decreased 75%.

  The Japan Society of Mechanical Engineers, 2007, The proceedings of the JSME annual meeting, 2007, 271 - 272, Japanese


• 1048 Development of a Wearable System for "The Hyper Hospital"

  KISHIMOTO Masamichi, Yoshida Toshihiko, NAKAMURA Hiromi, Okubo Masahiko, SUZUKI Yuta, HAYASAKA Tomoaki, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  To solve an aging problem in the society, it is important that the aged people are encouraged to be independent and spend healthy life. We have proposed the concept of the Hyper Hospital, which is the information support system for patients. In the Hyper Hospital, some units analyze their vital data, and patient's family who lives in the distance, the neighborhood and their doctor share the analyzed data through computer network to know their health condition. In this paper, we present a wearable platform for monitoring health condition. This platform sends the analyzed biomedical signal of a patient to a database server in his/her house. We developed a sensor module to acquire EMG that informs weakening of muscular strength by an underexercise or disease such as a hemiplegia. We confirmed that the sensor module works well with storage module and analysis module through some experiment. We also developed a database server for collecting data from any other sensor module and processing the data from each module separately. The proposed system will be expected monitoring health condition of the elderly.

  The Japan Society of Mechanical Engineers, 2007, The proceedings of the JSME annual meeting, 2007, 57 - 58, Japanese


• 1126 A Simulation Model for the Growth of Cerebral Aneurysms Based on a Hemodynamic Theory

  SHIMOGONYA Yuji, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The mechanism of the growth of cerebral aneurysm has not yet been understood. We focus on biological reactions in addition to purely mechanical process. We propose a simulation model to express the assumption that surface areas of the arterial wall are increased locally where wall shear stress value is much higher. We applied the model to a U-shaped artery with torsion. The resultant shape was consistent with clinical observations. It is concluded that it is necessary to consider biological reactions to understand the growth of the cerebral aneurysm.

  The Japan Society of Mechanical Engineers, 2007, The proceedings of the JSME annual meeting, 2007, 91 - 92, Japanese


• 1125 Inflow Rate into Cerebral Aneurysms in Curved Arteries

  IMAI Yohsuke, SATO Kodai, ISHIKAWA Takuji, YAMAGUCHI Takami

  This paper focuses on inflow into an aneurysm from its parent artery. Understandings of the inflow are required in designing endovascular devices such as coils and stents. A parametric computational fluid dynamics study of the inflow is performed for saccular cerebral aneurysms at a variety of arterial bends. Numerical results show that the inflow rate is strongly influenced by parent arterial geometry because secondary flow momentum in the parent artery determines the inflow. We also present that the shape of an aneurysm little affects the inflow rate.

  The Japan Society of Mechanical Engineers, 2007, The proceedings of the JSME annual meeting, 2007, 89 - 90, Japanese


• 1124 Flow Analysis of Malaria infected Blood using Particle Method

  Kondo Hitoshi, Tsubota Ken-ichi, Imai Yohsuke, Ishikawa Takuji, Yamaguchi Takami

  Malaria is one of the most serious diseases for all around the world. It is thought that severe symptoms are caused by microvasucular occlusions of parasitized red blood cells (PRBC) that have adhesive property and low deformability. However, the detailed mechanisms of the vascular occlusion caused by red blood cells are still not clear. In this study, the malaria-infected blood is modeled by particles. The adhesive property of PRBC is expressed by local spring. The result shows that the PRBC interacts with some healthy RBCs and move downstream keeping attachment to the vessel wall. This phenomenon induces the high resistance to the flow, which is likely to lead to microvascular obstruction in lower shear flow.

  The Japan Society of Mechanical Engineers, 2007, The proceedings of the JSME annual meeting, 2007, 87 - 88, Japanese


• Computational biomechanics of blood flow in cardiovascular diseases

  T. Yamaguchi, T. Ishikawa, K. Tsubota, Y. Imai, D. Mori, N. Matsuki

  World Scientific Publishing Co., Jan. 2007, Biomechanics at Micro- and Nanoscale Levels, 4, 130 - 140, English

  [Refereed]

  In book


• Effect of Aneurysmal Geometry on the Distribution of ATP Concentration

  K. Sato, Y. Imai, T. Ishikawa, A. Comerford, T. David, T. Yamaguchi

  Jan. 2007, The 9th Int. Symp. Future Med. Eng. based on Bio-nanotech., 128 - 129, English

  [Refereed]


• Tracking Red Blood Cells in a Circular PDMS Microchannel using a Confocal Micro-PIV System

  R. Lima, T. Ishikawa, S. Tanaka, M. Takeda, Y. Imai, K. Tsubota, S. Wada, T. Yamaguchi

  Jan. 2007, The 9th Int. Symp. Future Med. Eng. based on Bio-nanotech., 126 - 127, English

  [Refereed]


• Numerical Simulation on the Growth of Saccular Aneurysm

  Y. Shimogonya, Y. Imai, T. Ishikawa, T. Yamaguchi

  Jan. 2007, The 9th Int. Symp. Future Med. Eng. based on Bio-nanotech., 94 - 95, English

  [Refereed]


• Numerical simulation of a low-hematocrit blood flow in a small artery with stenosis

  T. Ishikawa, N. Kawabata, Y. Imai, K. Tsubota, T. Yamaguchi

  The blood flow in a large artery is commonly analyzed by means of constitutive equations. However, it is not appropriate to use these equations for small arteries because of the heterogeneity of the blood. In this study, we use a bead-spring model for an erythrocyte to simulate a low-hematocrit blood flow in a small artery with a stenosis. The flow field is solved using Euler coordinates, whereas the motion of the erythrocyte is solved using Lagrangian coordinates (two-way coupling). The results show that the erythrocytes are considerably deformed around the stenosis and that the separated region downstream of the stenosis is weakened by the erythrocytes.

  The Japan Society of Mechanical Engineers, Jan. 2007, Journal of Biomechanical Science and Engineering, 2(1) (1), 12 - 22, English

  [Refereed]

  Scientific journal


• Development of a wearable watch over system for patients home with an accelerometer

  T. Yoshida, H. Nakamura, M. Kishimoto, F. Mizuno, T. Hayasaka, K. Tsubota, Y. Imai, T. Ishikawa, T. Yamaguchi

  Dec. 2006, Proc. 2nd Tohoku-NUS Joint Symp. Future Nano-med. Bioeng. in the East Asian Region as the 8th Int. Symp. Future Med. Eng. Based on Bio-nanotech., 120 - 121, English

  [Refereed]


• Numerical analysis of ATP transport in aneurysms

  K. Sato, Y. Imai, T. Ishikawa, A. Comerford, T. David, T. Yamaguchi

  Dec. 2006, Proc. 2nd Tohoku-NUS Joint Symp. Future Nano-med. Bioeng. in the East Asian Region as the 8th Int. Symp. Future Med. Eng. Based on Bio-nanotech., 118 - 119, English

  [Refereed]


• Monitoring physical and mental workloads by wearable system for elderly home care

  H. Nakamura, T. Yoshida, Y. Imai, T. Ishikawa, T. Yamaguchi

  Dec. 2006, Proc. 2nd Tohoku-NUS Joint Symp. Future Nano-med. Bioeng. in the East Asian Region as the 8th Int. Symp. Future Med. Eng. Based on Bio-nanotech., 122 - 123, English

  [Refereed]


• Development of a wearable system for an quantification measurment of human motions in daily life

  M. Kishimoto, H. Nakamura, T. Yoshida, F. Mizuno, T. Hayasaka, Y. Imai, K. Tsubta, T. Ishikawa, T. Yamaguchi

  Dec. 2006, Proc. 15th Int. Conf. Mechanics in Medicine and Biology, 187 - 188, English

  [Refereed]


• Computer simulation of effects of deformabilities of red blood cells on blood flow using particle method

  K. Tsubota, S. Wada, Y. Imai, T. Ishikawa, T. Yamaguchi

  Dec. 2006, Proc. 15th Int. Conf. Mechanics in Medicine and Biology, 422 - 423, English

  [Refereed]


• An adaptive mesh refinement method for CFD analysis of arterial blood flow

  Y. Imai, T. Aoki, T. Ishikawa, K. Tsubota, T. Yamaguchi

  Dec. 2006, Proc. 15th Int. Conf. Mechanics in Medicine and Biology, 80 - 81, English

  [Refereed]


• Numerinal simulation of a low Hematocrit blood flow in a small artery with stenosis

  T. Ishikawa, N. Kawabata, Y. Imai, K. Tsubota, T. Yamaguchi

  Dec. 2006, Proc. 15th Int. Conf. Mechanics in Medicine and Biology, 420 - 421, English

  [Refereed]


• Computational Blood Flow Analysis-New Trends and Methods

  T. Yamaguchi, T. Ishikawa, K. Tsubota, Y. Imai, M. Nakamura, T. Fukui

  Over the past few decades, a large number of novel numerical methods have been proposed to analyze blood flows and to understand the relationship between vascular diseases and hemodynamics. In this paper, we review recent computational fluid dynamics studies on macroscale hemodynamics such as blood flow in the heart and large arteries, microscale blood flows in small vessels in which blood is assumed to be a suspension of red blood cells in plasma, and single red blood cell motions in an induced flow field. The advantages and disadvantages of numerical methods are discussed, and current trends in these research fields are introduced.

  The Japan Society of Mechanical Engineers, Oct. 2006, Journal of Biomechanical Science and Engineering, 1(1) (1), 29 - 50, English

  [Refereed]

  Scientific journal


• Accuracy study of the IDO scheme by Fourier analysis

  Yohsuke Imai, Takayuki Aoki

  Sep. 2006, JOURNAL OF COMPUTATIONAL PHYSICS, 217(2) (2), 453 - 472, English

  [Refereed]

  Scientific journal


• A higher-order implicit IDO scheme and its CFD application to local mesh refinement

  Y. Imai, T. Aoki

  Aug. 2006, Computational Mechanics, 38(3) (3), 211 - 224, English

  [Refereed]

  Scientific journal


• Stable coupling between vector and scalar variables for the IDO scheme on collocated grids

  Y Imai, T Aoki

  Jun. 2006, JOURNAL OF COMPUTATIONAL PHYSICS, 215(1) (1), 81 - 97, English

  [Refereed]

  Scientific journal


• Fourth-order accurate IDO scheme using gradient-staggered interpolation

  Y Imai, T Aoki

  Nov. 2004, JSME INTERNATIONAL JOURNAL SERIES B-FLUIDS AND THERMAL ENGINEERING, 47(4) (4), 681 - 689, English

  [Refereed]

  Scientific journal


• A numerical method on Cartesian grid for Image-based blood flow simulation

  今井陽介, 青木尊之, 布施智之, 池平博夫

  We have developed a numerical method on Cartesian grid for image-based blood flow simulation. Cartesian grid has advantages for grid generation for the complex and moving boundary problems. Interpolated Differential Operator (IDO) scheme with Local Mesh Refinement method are effectively introduced for blood flow simulations. In order to simulate flow interacting with elastic vessel on Cartesian grid, a new technique INTERGRID has been developed and it is shown that the simulation of fluid-structure interaction problems that structure does not displace over the resolution of grid is carried out.

  The Japan Society of Mechanical Engineers, Sep. 2004, Transactions of the Japan Society of Mechanical Engineers, Series A, 70(697) (697), 1232 - 1239, Japanese

  [Refereed]

  Scientific journal

• 細胞膜の拡大による樹状突起スパインのアイソジオメトリック解析—An isogeometric analysis of dendritic spine morphogenesis induced

  芥川 侑真, 林 桃郷, 竹田 宏典, 石田 駿一, 今井 陽介

  東京 : 日本計算工学会, Jun. 2024, 計算工学講演会論文集 = Proceedings of the Conference on Computational Engineering and Science / 日本計算工学会 編, 29, 1286 - 1290, Japanese


• アイソジオメトリック境界要素法による超弾性体シートの沈降挙動解析—An analysis of sedimentation of a hyperelastic sheet using isogeometric boundary element method

  舩越 啓樹, 竹田 宏典, 石田 駿一, 今井 陽介

  東京 : 日本計算工学会, Jun. 2024, 計算工学講演会論文集 = Proceedings of the Conference on Computational Engineering and Science / 日本計算工学会 編, 29, 1228 - 1230, Japanese


• 弾性管の蠕動運動により生じる管内流れのアイソジオメトリック境界要素解析—Isogeometric boundary element analysis of flow driven by peristaltic motion of an elastic tube

  竹田 宏典, 栗原 睦典, 石田 駿一, 今井 陽介

  東京 : 日本計算工学会, Jun. 2024, 計算工学講演会論文集 = Proceedings of the Conference on Computational Engineering and Science / 日本計算工学会 編, 29, 1225 - 1227, Japanese


• 粘性流体との相互作用による薄膜の変形の流体構造連成解析—A fluid-structure interaction analysis of the thin film deformation due to interaction with

  林 桃郷, 竹田 宏典, 石田 駿一, 今井 陽介

  東京 : 日本計算工学会, Jun. 2024, 計算工学講演会論文集 = Proceedings of the Conference on Computational Engineering and Science / 日本計算工学会 編, 29, 1231 - 1236, Japanese


• An isogeometric analysis of dendritic spine morphogenesis induced by cell membrane expansion

  芥川侑真, 林桃郷, 竹田宏典, 石田駿一, 今井陽介

  2024, 計算工学講演会論文集(CD-ROM), 29


• 粘性流体中で成長する薄膜の変形のアイソジオメトリック解析—An isogeometric analysis of deformation of a growing thin menbrane in a viscous fluid

  林 桃郷, 竹田 宏典, 石田 駿一, 今井 陽介

  東京 : 日本計算工学会, May 2023, 計算工学講演会論文集 = Proceedings of the Conference on Computational Engineering and Science / 日本計算工学会 編, 28, 761 - 766, Japanese


• Large scale parallel computing of cerebral circulation

  石田駿一, 北出宏紀, 伊井仁志, 今井陽介, 和田成生

  2019, 計算工学講演会論文集(CD-ROM), 24


• Development of whole-scale cerebral blood flow simulator

  石田駿一, 北出宏紀, 伊井仁志, 今井陽介, 和田成生

  2019, バイオエンジニアリング講演会講演論文集(CD-ROM), 32nd


• Modeling of cerebrovasculature network and numerical simulation of whole-scale cerebral circulation

  石田駿一, 北出宏紀, 伊井仁志, 今井陽介, 和田成生

  2019, 日本機械学会計算力学講演会論文集(CD-ROM), 32nd


• FLUID-STRUCTURE INTERACTIONS OF NODAL CILIA AXONEME

  Toshihiro Omori, Hiroto Sugai, Yohsuke Imai, Takuji Ishikawa

  Sep. 2018, 8th International Conference on Fluid Mechanics (ICFM8), S10BM0-04, English

  [Refereed]

  Summary international conference


• 重力に依存した嚥下運動の数値流体力学シミュレーションの開発

  太田 淳, 石田 駿一, 川瀬 哲明, 香取 幸夫, 今井 陽介

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 569 - 569, Japanese


• 嚥下の3D数値流体力学シミュレーションの開発と検討

  太田淳, 石田駿一, 川瀬哲明, 香取幸夫, 今井陽介

  2018, 日本嚥下医学会抄録(Web), 41st


• Integrated nano-biomechanics

  Takami Yamaguchi, Takuji Ishikawa, Yohsuke Imai

  Elsevier, 01 Jan. 2018, Integrated Nano-Biomechanics, 1 - 297, English

  Others


• Modeling the cerebral vasculature for numerical simulation in whole scale cerebral blood flow circulation

  北出宏紀, 伊井仁志, 今井陽介, 石田駿一, 和田成生

  2018, 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM), 29th


• 実形状モデルを用いた胃内流動の数値計算

  石田駿一, 宮川泰明, O’GRADY Gregory, CHENG Leo K., 今井陽介

  2018, 数値流体力学シンポジウム講演論文集(CD-ROM), 32nd


• 胃内容物の撹拌・排出の数値シミュレーション

  石田駿一, 宮川泰明, O’GRADY Gregory, CHENG Leo K., 今井陽介

  2018, バイオエンジニアリング講演会講演論文集(CD-ROM), 31st


• Numerical analysis of gastric mixing and emptying

  石田駿一, 宮川泰明, O’GRADY Gregory, CHENG Leo K., 今井陽介

  2018, 日本機械学会計算力学講演会論文集(CD-ROM), 31st


• 胃から十二指腸への食物排出の数値計算

  今井陽介, 石田駿一, 宮川泰明, O’GRADY Gregory, CHENG Leo K.

  2017, 計算工学講演会論文集(CD-ROM), 22


• 胃における蠕動運動と流れの関係についての一考察

  宮川泰明, 石田駿一, 今井陽介

  2017, 日本機械学会計算力学講演会論文集(CD-ROM), 30th


• 胃壁の運動機能と胃内容物攪拌の関係

  宮川泰明, 今井陽介, 石田駿一, 山口隆美, 石川拓司

  2017, バイオエンジニアリング講演会講演論文集(CD-ROM), 29th


• 胃内部の固体粒子挙動の数値計算

  石田駿一, 今井陽介, 宮川泰明, 石川拓司

  2017, バイオエンジニアリング講演会講演論文集(CD-ROM), 29th


• A Numerical Analysis of Cell Adhesion in Microcirculation

  武石 直樹, 今井 陽介, カム ロジャー, 石川 拓司

  日本計算工学会, May 2016, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 21, 4p, Japanese


• 2E32 Numerical Analysis Concerning the Reorientation Phenomenon of Sedimenting Red Blood Cell

  Matsunaga Daiki, Imai Yohsuke, Wagner Christian, Ishikawa Takuji

  When keeping blood inside a static tube, it is well known that the red blood cells (RBCs) start to sediment downward due to the density difference between inner fluid and the outer fluid plasma. In present work, we numerically investigate the orientation angle of settling RBCs. First, we confirm that the RBCs change its orientation toward vertical angle as also reported in previous experimental studies. Secondly, we find that this reorientation is faster for a red blood cell with higher Bond number or lower viscosity ratio. In this report, we also discuss how this reorientation speed would impact the overall trajectories of the RBCs.

  The Japan Society of Mechanical Engineers, 09 Jan. 2016, バイオエンジニアリング講演会講演論文集, 2016(28) (28), "2E32 - 1"-"2E32-4", Japanese


• 2E24 Clarification of the hydrodynamic factors influencing blood cell lateral migration

  NIX Stephanie, IMAI Yohsuke, ISHIKAWA Takuji

  In the blood, cells are observed to move perpendicular to the direction of the blood flow in a process called lateral migration. This lateral migration occurs due to several hydrodynamic factors, such as the presence of the vessel wall, the applied Poiseuille flow within the vessel, and cell-cell interactions. However, the effect of these factors has not been well understood. Thus, using the boundary integral method, we have been numerically investigating the effect of the wall and the effect of the curvature of the applied flow on the lateral migration of a single cell. We have shown that the effect of the wall on cell lateral migration is dominant relative to the effect of the flow curvature, even at large distances between the cell and the wall. We have also derived a semi-analytical equation representing the relative effects of the wall and flow curvature, which allows us to predict the migration velocity in slit flows or microvessels. Our results can also be used to develop simplified models, based on the position of the cell within the vessel, for biophysical phenomena such as cell margination and axial migration.

  The Japan Society of Mechanical Engineers, 09 Jan. 2016, バイオエンジニアリング講演会講演論文集, 2016(28) (28), "2E24 - 1"-"2E24-4", English


• 1C46 Numerical simulation of a swimming ciliate near a water-air or a water-wall interface

  MANABE Junichi, OMORI Toshihiro, IMAI Yohsuke, ISHIKAWA Takuji

  Swimming behavior of microorganism near an interface is important to understand how to prevent bio-film formation, which can be a cause of medical instrument pollution. Recently, we found that a ciliate can be trapped at a water-air interface, though swims away from a water-wall interface. We conducted numerical simulation of swimming microorganism near an interface from hydrodynamic perspective, to reveal the entrapment mechanism. By mimicking microorganism shape in detail, our microorganism model reproduced entrapment phenomena for the first time in the world. We concluded that shape of a ciliate dominates the entrapment phenomena.

  The Japan Society of Mechanical Engineers, 09 Jan. 2016, バイオエンジニアリング講演会講演論文集, 2016(28) (28), "1C46 - 1"-"1C46-5", Japanese


• 1E11 Numerical simulation of cell adhesion in microchannels

  TAKEISHI Naoki, IMAI Yohsuke, YAMAGUCHI Takami, Kamm Roger D., ISHIKAWA Takuji

  We numerically investigate the velocity of an adherent cell in various sizes of microchannels. The velocity drastically decreases as decreasing the size of microchannels. When the channel size becomes smaller, the motion of the adherent cell changes from a "rolling motion" to a "bullet motion", where the cell rotates on side wall in rolling motion, while the cell adhere its circular arc to the wall in bullet motion. Larger adhesion force is generated in rear parts of rolling cell, and existed bonds experience rupturing with higher probability because of slip bond. Because cell cannot move forward unless the ligand-receptor bonds in rear parts rupture, frequent rupturing allows the rolling cell to move faster than the cell exhibiting bullet motion. As getting smaller in channel diameter, the surface area attached to the wall is larger and then the number of ligand-receptor bonds is larger for smaller microchannels, resulting in a lower velocity. Our numerical model allows us to investigate the effect of various parameters on adherent cell velocity.

  The Japan Society of Mechanical Engineers, 09 Jan. 2016, バイオエンジニアリング講演会講演論文集, 2016(28) (28), "1E11 - 1"-"1E11-5", Japanese


• 195 Numerical simulation of a sperm cell swimming in a viscoelastic fluid

  SHIMOMURA Eisaku, OMORI Toshihiro, IMAI Yhosuke, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 2016, 講演論文集, 2016(51) (51), 187 - 188, Japanese


• 蠕動運動と胃内容物攪拌の関係

  宮川泰明, 今井陽介, 石田駿一, 山口隆美, 石川拓司

  2016, バイオエンジニアリング講演会講演論文集(CD-ROM), 28th


• 197 Measurement of the behavior of cancer cells cultivated on a collagen gel

  Iwasaki Yuwa, Imai Yohsuke, Kikuchi Kenji, Numayama-Tsuruta Keiko, Shigeta Shunsuke, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 2016, The Proceedings of Conference of Tohoku Branch, 2016(0) (0), 191 - 192, Japanese


• B212 A numerical simulation of cytoskeletal dynamics

  SAITO Fumiyasu, IMAI Yohsuke, ISHIDA Shunichi, OMORI Toshihiro, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 01 Oct. 2015, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2015(26) (26), 123 - 124, Japanese


• PS8-15 Mechanics of nodal cilia in early mouse embryo(PS8: Poster Short Presentation VIII,Poster Session)

  Omori Toshihiro, Sugai Hiroto, Imai Yohsuke, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 16 Sep. 2015, Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) (8), 366 - 366, English


• PS8-14 Visualization of intestinal peristalsis of mosquito midgut by using micro X-ray imaging(PS8: Poster Short Presentation VIII,Poster Session)

  Kikuchi Kenji, Imai Yohsuke, Numayama-Tsuruta Keiko, Yamaguchi Takami, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 16 Sep. 2015, Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) (8), 365 - 365, English


• PS3-7 DEVELOPMENT OF A NUMERICAL MODEL OF CYTOSKELETON DYNAMICS(PS3: Poster Short Presentation III,Poster Session)

  Saito Fumiyasu, Imai Yohsuke, Ishida Shunichi, Omori Toshihiro, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 16 Sep. 2015, Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) (8), 268 - 268, English


• PS3-1 Hydrodynamic behavior of small particles in a microchannel(PS3: Poster Short Presentation III,Poster Session)

  Takeishi Naoki, Imai Yohsuke, Yamaguchi Takami, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 16 Sep. 2015, Proceedings of the ... Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics, 2015(8) (8), 262 - 262, English


• Capsule lateral migration : shear gradient vs. wall

  Nix Stephanie, Imai Yohsuke, Ishikawa Takuji

  日本計算工学会, Jun. 2015, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 20, 3p, English


• 1A15 A numerical simulation of rolling and adhesion of red blood cells infected by malaria

  ICHIKAWA Yuki, IMAI Yohsuke, MATSUNAGA Daiki, NIX Stephanie, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015(27) (27), 11 - 12, Japanese


• 1A16 Numerical Simulation of the Nodal Ciliary Motion Driven by the Dynein Motor Protein

  SUGAI Hiroto, Omori Toshihiro, IMAI Yohsuke, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 08 Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015(27) (27), 13 - 14, Japanese


• 1A12 Behavior of tracer particles in capsule suspensions : the effect of size of tracer particles

  ITO Hiroki, IMAI Yohsuke, MATSUNAGA Daiki, Omori Toshihiro, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 08 Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015(27) (27), 5 - 6, Japanese


• 1D35 Rheology of a red blood cell suspension in a simple shear flow

  OMORI Toshihiro, ISHIKAWA Takuji, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2015, バイオエンジニアリング講演会講演論文集, 2015(27) (27), 165 - 166, Japanese


• 胃内のせん断応力の数値解析

  宮川泰明, 今井陽介, 石田駿一, 山口隆美, 石川拓司

  2015, バイオエンジニアリング講演会講演論文集, 27th


• 胃内容物攪拌の数値計算:胃壁の運動の影響

  宮川泰明, 今井陽介, 石田駿一, 山口隆美, 石川拓司

  2015, 計算工学講演会論文集(CD-ROM), 20


• A112 Numerical Simulation of the Ciliary Motion Driven by the Motor Protein

  SUGAI Hiroto, OMORI Toshihiro, IMAI Yohsuke, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 02 Oct. 2014, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2014(25) (25), 21 - 22, Japanese


• A111 A numerical simulation of a microorganism behavior near an interface

  Manabe Junichi, Kyouya Kouhei, Omori Toshihiro, Imai Yohsuke, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 02 Oct. 2014, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2014(25) (25), 19 - 20, Japanese


• Numerical analysis of dense capsule suspension with changing volume fraction

  松永 大樹, 今井 陽介, 山口 隆美

  日本計算工学会, Jun. 2014, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 19, 4p, Japanese


• 2G34 A simulation of nutrient uptake in a suspension of squirmers

  KAJIKI Shunsuke, IMAI Yohsuke, Yamaguchi Takami, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 539 - 540, Japanese


• 1G43 A numerical simulation of the cytoadhesion of malaria-infected red blood cells using a ligand-receptor interaction model

  AMI Akihisa, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 245 - 246, Japanese


• 1G44 A numerical analysis of the behavior of cancer cells related to hematogenous metastasis in microvasculature

  TAKEISHI Naoki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 247 - 248, Japanese


• 1G33 A numerical simulation of motion of food in the stomach

  MIYAGAWA Taimei, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 235 - 236, Japanese


• 2E15 Numerical analysis of a red blood cell flowing through a micro flow channel

  OMORI Toshihiro, ISHIKAWA Takuji, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 439 - 440, Japanese


• 2E22 Mechanism of the non-linear response of viscosity to volume fraction in dense capsule suspension

  MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 445 - 446, Japanese


• 2E21 A numerical simulation of capsule behavior in a near-wall shear flow

  Nix Stephanie, IMAI Yohsuke, MATSUNAGA Daiki, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 10 Jan. 2014, バイオエンジニアリング講演会講演論文集, 2014(26) (26), 443 - 444, Japanese


• 167 気液界面における微生物の遊泳シミュレーション

  眞鍋 隼一, 京谷 浩平, 今井 陽介, 大森 俊宏, 石川 拓司

  一般社団法人日本機械学会, 2014, 講演論文集, 2014(49) (49), 131 - 132, Japanese


• J027014 Simulation of nutrient uptake by swimming microorganisms in a suspension

  KAJIKI Shunsuke, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  Little is known about the mass transport in microbial suspension in previous studies. The aim of this study is to analyze the effect of the swimming motion on the nutrient uptake. We modeled a microorganism as a squirmer and calculated its locomotion by boundary element method . Moreover we simulated the nutrient uptake by tracking nutrient particles. The results show that the nutrient uptake is strongly affected by the swimming mode of a microorganism.

  The Japan Society of Mechanical Engineers, 08 Sep. 2013, Mechanical Engineering Congress, Japan, 2013, "J027014 - 1"-"J027014-4", Japanese


• J027011 A Numerical Simulation of Collective Swimming of Microorganisms

  KYOYA Kohei, MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  Microorganisms play a vital role in many biological, medical and engineering phenomena. Some recent research efforts have demonstrated the importance of biomechanics in understanding certain aspects of microorganism behaviors such as locomotion and collective motions of cells. Previous studies had problems of high computational load in simulating many-body interaction of swimmers. In this study, we propose a boundary element method, based on the double-layer representation, for calculating interactions of many-body swimmers in Stokes flow regime. We use Graphic Processing Unit (GPU) to speed up the computation. We then analyze interactions of 100 swimmers.

  The Japan Society of Mechanical Engineers, 08 Sep. 2013, Mechanical Engineering Congress, Japan, 2013, "J027011 - 1"-"J027011-4", Japanese


• 102 A Numerical Analysis of Bimodal Capsule Suspensions

  ITO Hiroki, IMAI Yohsuke, MATSUNAGA Daiki, ISHIKAWA Takuji, YAMAGUCH Takami

  The Japan Society of Mechanical Engineers, 15 Mar. 2013, 講演論文集, 2013(48) (48), 8 - 9, Japanese


• 2B14 Rheological analysis of capsule suspension using boundary element method

  MATSUNAGA Daiki, IMAI Yohsuke, ISHIKAWA Takuji, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013(25) (25), 299 - 300, Japanese


• 2E02 Analysis of Red Blood Cell Behavior in a Narrow Tube

  HOSAKA Haruki, OMORI Toshihiro, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013(25) (25), 387 - 388, Japanese


• 2B19 A numerical analysis of the cell migration in microcirculatory blood flow

  TAKEISHI Naoki, IMAI Yohsuke, NAKAAKI Keita, ISHIKAWA Takuji, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013(25) (25), 307 - 308, Japanese


• 1D04 Numerical analysis of swimming model microorganisms by GPU

  KYOYA Kohei, MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 08 Jan. 2013, バイオエンジニアリング講演会講演論文集, 2013(25) (25), 117 - 118, Japanese


• 1D01 3D-PTV measurement of the phototactic movement of algae in the shear flow

  MAEDA Tatsuyuki, ISHIKAWA Takuji, UENO Hironori, NUMAYAMA-TSURUTA Keiko, IMAI Yosuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2013, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2013(0) (0), 111 - 112, Japanese


• 3E15 Measurement of ciliary flow generated on the surface of tracheal lumen

  KIYOTA Koki, UENO Hironori, ISHIKAWA Takuji, NUMAYAMA Keiko, IMAI Yohsuke, OMORI Toshihiro, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2013, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2013(0) (0), 609 - 610, Japanese


• J027013 Effect of aeration on the bio-convection of micro algae cells

  NONAKA Yuki, UENO Hironori, NUMAYAMA Keiko, OMORI Toshihiro, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  Bioconvection patterns are often observed in microalgae suspensions of randomly, but on average upwardly, swimming microalgae which are little denser than water. When we culture microalgae in the laboratory, we usually add aeration for mixing the culture fluid and supplying oxygen and carbon dioxide. However, the effect of aeration on the bioconvection pattern and the transport phenomena in the suspension is unclear. In this study, we investigated bioconvection pattern in a suspension of Chlamydomonas reinhardtii under the condition with aeration. Bioconvection pattern in a cylindrical container was visualized by red illumination, and white light for phototaxis could be added from above. Small bubbles were injected by a needle connected to a syringe. Observation of bioconvection patterns of microalgae suspension with aeration showed three kinds of flow patterns depending on the bubble flow rate. When there was no bubble flow, conventional bioconvection was dominant. When flow rate was low, observed pattern in the cylindrical container was split into two flow regions, where the bioconvection and the bubble flow were dominant respectively. When flow rate was high, bubble flow became dominant and no clear bioconvection was observed. Such changes in the bioconvection pattern have not been reported before. These findings are important to understand the transport phenomena in algae suspensions in engineering settings.

  The Japan Society of Mechanical Engineers, 2013, The Proceedings of Mechanical Engineering Congress, Japan, 2013(0) (0), _J027013 - 1-_J027013-4, Japanese


• C107 Bioconvection of micro algae cells under an aeration condition

  NONAKA Yuki, UENO Hirinori, NUMAYAMA Keiko, OMORI Toshihiro, IMAI Yosuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 2013, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2013(0) (0), 45 - 46, Japanese


• 103 Aggregation structure of algae in forced circulation bubbly flow

  NONAKA Yuki, UENO Hironori, NUMAYAMA-TSURUTA Keiko, OMORI Toshihiro, IMAI Yosuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 2013, The Proceedings of Conference of Tohoku Branch, 2013(0) (0), 10 - 11, Japanese


• 計算生体力学シミュレーションによるミクロからマクロスケールの生体機能の解析

  山口 隆美, 今井 陽介, 水野 文雄, 大森 俊宏, 上野 裕則, 沼山 恵子, 石川 拓司

  バイオメカニズム学会, Dec. 2012, バイオメカニズム学術講演会予稿集, 33回, 33 - 34, Japanese


• 806 Numerical simulation of dynamics of solid particles in the stomach

  MIYAGAWA Taimei, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Oct. 2012, The Computational Mechanics Conference, 2012(25) (25), 9 - 10, Japanese


• 807 Numerical analysis of swimming model microorganisms by a boundary element method based on the double-layer representation

  KYOYA Kohei, MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 06 Oct. 2012, The Computational Mechanics Conference, 2012(25) (25), 11 - 12, Japanese


• 803 Numerical simulation of adhesive phenomena of Pf-T-IRBC and the endothelial cells

  AMI Akihisa, IMAI Yohsuke, NAKAAKI Keita, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Oct. 2012, The Computational Mechanics Conference, 2012(25) (25), 3 - 4, Japanese


• A107 Simulation of nutrient uptake by a swimming model microorganism

  Kajiki Shunsuke, Kyoya Kohei, Matsunaga Daiki, Imai Yohsuke, Yamaguchi Takami, Ishikawa Takuji

  The Japan Society of Mechanical Engineers, 04 Oct. 2012, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2012(23) (23), 13 - 14, Japanese


• ストークス流れ中の非球形カプセルの配向現象

  石川拓司, 大森俊宏, 今井陽介, 山口隆美

  01 Sep. 2012, 京都大学数理解析研究所講究録, (1808) (1808), 121 - 126, Japanese

  Introduction research institution


• Development of a numerical model for micro-scale blood flow simulation using GPU computing

  武石 直樹, 今井 陽介, 中秋 慶太

  日本計算工学会, May 2012, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 17, 4p, Japanese


• Numerical Analysis of a Red Blood Cells in Simple Shear Flow

  大森 俊宏, 石川 拓司, 今井 陽介

  日本計算工学会, May 2012, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 17, 4p, Japanese


• Development of a multi GPU implementation of a boundary integral method for capsule flow

  松永 大樹, 今井 陽介, 石川 拓司

  日本計算工学会, May 2012, 計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, 17, 4p, Japanese


• 111 Simulation of mass absorption of swimming model microorganisms by a boundary element method

  KAJIKI Shunsuke, MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 13 Mar. 2012, 講演論文集, 2012(47) (47), 28 - 29, Japanese


• 110 Numerical analysis of swimming model microorganisms by a boundary element method

  Kyoya Kohei, MATSUNAGA Daiki, IMAI Yohsuke, YAMAGUCHI Takami, ISHIKAWA Takuji

  The Japan Society of Mechanical Engineers, 13 Mar. 2012, 講演論文集, 2012(47) (47), 26 - 27, Japanese


• 113 Numerical analysis of adhesive phenomena of malaria-infected red blood cells

  AMI Akihisa, IMAI Yohsuke, NAKAAKI Keita, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2012, 講演論文集, 2012(47) (47), 32 - 33, Japanese


• 109 Analysis of Red Blood Ce11 Deformation in Flow Field Using a Boundary Element Method

  Hosaka Haruki, Ishikawa Takuji, Omori Toshihiro, Imai Yohsuke, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2012, 講演論文集, 2012(47) (47), 24 - 25, Japanese


• 212 Development of a numerical model for blood flow in microvessels using GPGPU computing

  Takeishi Naoki, IMAI Yohsuke, NAKAAKI Keita, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2012, 講演論文集, 2012(47) (47), 230 - 231, Japanese


• 8G24 A 3-dimensional computation on gastric mixing using GPU.

  KOBAYASHI Ikuma, IMAI Yosuke, ISHIDA Shunichi, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012(24) (24), "8G24 - 1"-"8G24-2", Japanese


• 8F34 Development of a numerical model of microcirculatory blood flow in malaria infection based on GPU

  NAKAAKI Keita, IMAI Yohsuke, ISHIKAWA Takuji, Lim Chwee Teck, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012(24) (24), "8F34 - 1"-"8F34-2", Japanese


• 8F13 Development of a GPU computing platform for accurate simulations of large-scale cellular flow

  IMAI Yohsuke, MATSUNAGA Daiki, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012(24) (24), "8F13 - 1"-"8F13-2", Japanese


• 7H22 A fast simulation of pulmonary airflow and inhaled particles by GPU

  IMAI Yohsuke, MIKI Takahito, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2012, バイオエンジニアリング講演会講演論文集, 2012(24) (24), "7H22 - 1"-"7H22-2", Japanese


• 固体成分を含む胃内容物の攪拌の数値シミュレーション

  宮川泰明, 今井陽介, 小林生馬, 石川拓司, 山口隆美

  2012, 日本機械学会東北支部総会・講演会講演論文集, 47th


• 胃内部の固体粒子運動の数値シミュレーション

  宮川泰明, 今井陽介, 石川拓司, 山口隆美

  2012, 日本機械学会計算力学講演会論文集(CD-ROM), 25th


• 2306 A numerical computation on gastric mixing

  KOBAYASHI Ikuma, IMAI Yohsuke, ISHIDA Shunichi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Oct. 2011, The Computational Mechanics Conference, 2011(24) (24), 642 - 643, Japanese


• 2305 Numerical simulation of swallowing based on videofluorography

  ISHIDA Shunichi, IMAI Yohsuke, ISHIKAWA Takuji, KINJO Aki, MATSUKI Noriaki, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Oct. 2011, The Computational Mechanics Conference, 2011(24) (24), 639 - 641, Japanese


• 2308 A fast simulation of capsule motion in flow by GPU computing

  IMAI Yohsuke, MATSUNAGA Daiki, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Oct. 2011, The Computational Mechanics Conference, 2011(24) (24), 646 - 647, Japanese


• 2307 Development of GPU simulation of microcirculatory blood flow

  NAKAAKI Keita, IMAI Yohsuke, ISHIKAWA Takuji, Lim Chwee Teck, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Oct. 2011, The Computational Mechanics Conference, 2011(24) (24), 644 - 645, Japanese


• B112 Development of GPU computing method for capsule suspension

  MATSUNAGA Daiki, IMAI Yohsuke, OMORI Toshihiro, MIKI Takahito, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Oct. 2011, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2011(22) (22), 61 - 62, Japanese


• 184 Numerical simulation of red blood cell flow in micro vessels : effects of endothelial cell geometry

  FUJIWARA Masaki, IMAI Yohsuke, NAKAAKI Keita, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 15 Mar. 2011, 講演論文集, 2011(46) (46), 170 - 171, Japanese


• 9G-17 Numerical simulation of swallowing based on videofluorography

  ISHIDA Shunichi, IMAI Yohsuke, ISHIKAWA Takuji, KINJO Aki, MATSUKI Noriaki, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010(23) (23), 559 - 560, Japanese


• 9G-16 Development of a computational fluid dynamics model of gastric mixing

  IMAI Yohsuke, KOBAYASHI Ikuma, ISHIDA Shunichi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010(23) (23), 557 - 558, Japanese


• 9E-08 Numerical analysis of cell behavior in blood flow

  MATSUMOTO Yoshihiro, IMAI Yohsuke, ALIZADEHRAD Davod, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 07 Jan. 2011, バイオエンジニアリング講演会講演論文集, 2010(23) (23), 389 - 390, Japanese


• 182 Development of microdevice for sorting motile bacteria

  SHIOIRI Tatsuya, ISHIKAWA Takuji, NUMAYAMA Keiko, IMAI Yohsuke, UENO Hironori, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2011, The Proceedings of Conference of Tohoku Branch, 2011(0) (0), 166 - 167, Japanese


• 9J-07 Analysis of cancer cell membrane protein movement by confocal PTV system

  YOSHIMOTO Takefumi, ISHIKAWA Takuji, NUMAYAMA Keiko, MATSUKI Noriaki, TANAKA Tatsuya, UENO Hironori, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2011, The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2010(0) (0), 487 - 488, Japanese


• 187 Flow measurement of bacterial suspensions in a tube by a confocal micro-PIV system

  MAEDA Tatsuyuki, ISHIKAWA Takuji, NUMAYAMA Keiko, IMAI Yosuke, UENO Hironori, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2011, The Proceedings of Conference of Tohoku Branch, 2011(0) (0), 176 - 177, Japanese


• A107 Changes in blood flow caused by adhesive properties of malaria-infected red blood cells

  NAKAAKI Keita, IMAI Yohsuke, KONDO Hitoshi, ISHIKAWA Takuji, Teck Lim Chwee, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 11 Nov. 2010, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2010(21) (21), 13 - 14, Japanese


• A108 Effects of content volume on the flow in a stomach

  KOBAYASHI Ikuma, IMAI Yohsuke, ISHIDA Shunichi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 11 Nov. 2010, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2010(21) (21), 15 - 16, Japanese


• 164 Numerical simulation of gastric mixing by particle method

  KOBAYASHI Ikuma, IMAI Yohsuke, ISIDA Shunichi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 12 Mar. 2010, 講演論文集, 2010(45) (45), 128 - 129, Japanese


• 192 Three-dimensional simulation of behavior of malaria infected red blood cell in blood flow

  NAKAAKI Keita, IMAI Yohsuke, KONDO Hitoshi, ISHIKAWA Takuji, Teck Lim Chwee, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 12 Mar. 2010, 講演論文集, 2010(45) (45), 184 - 185, Japanese


• 196 Basic Study for Bio-micropump by using Escherichia coli

  Matsuura Ryo, Ishikawa Takuji, Ueno Yusuke, Imai Yohsuke, Matsuki Noriaki, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 12 Mar. 2010, 講演論文集, 2010(45) (45), 192 - 193, Japanese


• 193 Measurement of mesoscopic flow structure in a suspension of Escherichia coli by using micro-PIV system

  YOSHIDA Naoto, ISHIKAWA Takuji, UENO Yusuke, MATSUKI Noriaki, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 12 Mar. 2010, 講演論文集, 2010(45) (45), 186 - 187, Japanese


• 194 Behavior of cancer cells flowing in microchannels

  TANAKA Tatsuya, ISHIKAWA Takuji, MATSUKI Noriaki, IMAI Yohsuke, UENO Yusuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 12 Mar. 2010, 講演論文集, 2010(45) (45), 188 - 189, Japanese


• 0205 Effects of adhesion property of malaria infected red blood cells on blood flows

  IMAI Yohsuke, NAKAAKI Keita, KONDo Hitoshi, KANG Young Ho, ISHIKAWA Takuji, LIM Chwee Teck, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009(22) (22), 14 - 14, Japanese


• 0625 Patient-specific morphological and blood flow analysis of pulmonary artery in the case of severe deformations of the lung

  CHRISTOPHE Jean-Joseph, ISHIKAWA Takuji, IMAI Yohsuke, MATSUKI Noriaki, TAKASE Kei, THIRIET Marc, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009(22) (22), 280 - 280, Japanese


• 0513 Computation biomechanics of transport phenomenon in the small intestine

  SATO Takuya, ISHIKAWA Takuji, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009(22) (22), 270 - 270, Japanese


• 1005 Monitoring system of water content in a body by bioimpedance method

  WATANABE Aya, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009(22) (22), 169 - 169, Japanese


• 0914 Development of a mobile toilet system for elderly

  Ueno Sozo, IMAI Yohsuke, Hayasaka Tomoaki, Mizuno Fumio, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 08 Jan. 2010, バイオエンジニアリング講演会講演論文集, 2009(22) (22), 156 - 156, Japanese


• B210 Development of a micro fluidic device to sort circulating tumor cells from a blood sample

  TANAKA Tatsuya, ISHIKAWA Takuji, MATSUKI Noriaki, IMAI Yohsuke, UENO Hironori, NUMAYAMA-TSURUTA Keiko, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 2010, The Proceedings of the JSME Conference on Frontiers in Bioengineering, 2010(0) (0), 105 - 106, Japanese


• B210 Patient-specific study on pulmonary blood now in the case of severe deformations of the lung

  CHRISTOPHE Jean-Joseph, ISHIKAWA Takuji, IMAI Yohsuke, MATSUKI Noriaki, THIRIET Marc, TAKASE Kei, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Nov. 2009, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2009(20) (20), 111 - 112, English


• B209 Effect of anti-cancer drug on the rheological property of cancer cells

  YOSHIMOTO Takefumi, ISHIKAWA Takuji, MATSUKI Noriaki, IMAI Yohsuke, UENO Hironori, TAKEDA Motohiro, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Nov. 2009, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2009(20) (20), 109 - 110, Japanese


• B106 Motion analysis of bolus and epiglottis based on VF images

  ISHIDA Shunichi, IMAI Yohsuke, MATSUKI Noriaki, KINJO Aki, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Nov. 2009, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2009(20) (20), 39 - 40, Japanese


• 2001 Development of a three-dimensional model of hemodynamics arising from malaria infection

  IMAI Yohsuke, KONDO Hitoshi, Ho Kang Young, ISHIKAWA Takuji, Teck Lim Chwee, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 10 Oct. 2009, The Computational Mechanics Conference, 2009(22) (22), 544 - 545, Japanese


• 変形機構を有する室内飛行船の開発

  広瀬量平, 今井陽介, 石川拓司, 山口隆美

  Oct. 2009, ブイヤント航空, 37, 81 - 88, Japanese

  Introduction other


• K-014 Development of a mobile toilet system for solitary elderly people

  Ueno Sozo, Imai Yohsuke, Hayasaka Tomoaki, Ishikawa Takuji, Yamaguchi Takami

  Forum on Information Technology, 20 Aug. 2009, 情報科学技術フォーラム講演論文集, 8(3) (3), 555 - 556, Japanese


• 151 Airship type watch-over system cruising in a house with occasional deformation

  HIROSE Ryohei, ISHIKAWA Takuji, IMAI Yhousuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 100 - 101, Japanese


• 187 The relationship between cancer cell deformability and its metastasis

  YOSHIMOTO Takefumi, ISHIKAWA Takuji, MATSUKI Noriaki, FUJIWARA Hiroki, IMAI Yhousuke, UENO Hironori, TAKEDA Motohiro, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 168 - 169, Japanese


• 198 Flow analysis of digested material in the small intestine

  SATO Takuya, ISHIKAWA Takuji, SHIMOGONYA Yuji, IMAI Yosuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 188 - 189, Japanese


• 188 Basic study on monitoring system of water content in a body for elderly people

  WATANABE Aya, IMAI Yhousuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 170 - 171, Japanese


• 190 A study on the mechanism of swallowing using videofluorography

  Ishida Shunichi, Imai Yhousuke, Matsuki Noriaki, Kinjo Aki, Ishikawa Takuji, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 174 - 175, Japanese


• 189 Quantification of mechanical stimulus to induce avoiding reaction of Paramecium

  Ishiguro Takashi, Ishikawa Takuji, Matsuki Noriaki, Ueno Hironori, Imai Yhousuke, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 172 - 173, Japanese


• 199 Development of a numerical model of rosettes in malaria infection

  KANG Yongho, IMAI Yosuke, KONDO Hitoshi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 13 Mar. 2009, 講演論文集, 2009(44) (44), 190 - 191, Japanese


• 439 Development of a mobile toilet robot

  Ueno Sozo, IMAI Yohsuke, Hayasaka Tomoaki, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008(21) (21), 411 - 412, Japanese


• 434 Development of respiration monitoring system for home-care

  OKUBO Masahiko, IMAI Yohsuke, ISHIKAWA Takuji, HAYASAKA Tomoaki, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008(21) (21), 401 - 402, Japanese


• 215 Measurement of blood flow through bifurcation and confluence of microchannel with confocal micro-PIV system

  FUJIWARA Hiroki, ISHIKAWA Takuji, MATSUKI Noriaki, YOSHIMOTO Takefumi, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Jan. 2009, バイオエンジニアリング講演会講演論文集, 2008(21) (21), 87 - 88, Japanese


• B412 An automatic inhaler control system based on respiration monitoring

  OKUBO Masahiko, IMAI Yohsuke, ISHIKAWA Takuji, HAYASAKA Tomoaki, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008(19) (19), 153 - 154, Japanese


• B203 Behavior of a Red Blood Cell in a Simple Shear Flow Simulated by a Boundary Element Method

  OMORI Toshihiro, ISHIKAWA Takuji, BARTHES-BIESEL Dominique, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008(19) (19), 47 - 48, Japanese


• B209 A Locomotive System Mimicking Pedal Locomotion of Snails for the Capsule Endoscope

  HOSOKAWA Daisuke, ISHIKAWA Takuji, MORIKAWA Hirohisa, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 22 Sep. 2008, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2008(19) (19), 58 - 59, Japanese


• 1G3-2 Development of a mobile toilet system

  Ueno Sozo, IMAI Yohsuke, Hayasaka Tomoaki, ISHIKAWA Takuji, YAMAGUCHI Takami

  A number of elderly people have a difficulty in going to the toilet by themselves. They sometimes wear an adult diaper but it makes the elderly uncomfortable and unsanitary. Moreover, their pride is injured by wearing the diaper. A portable toilet is also used for the elderly requiring assistance to the toilet. The portable toilet is not a sufficient solution because it is also uncomfortable and unsanitary for them. We propose a mobile toilet system for solving this problem. The concept of the proposed system is as follows. The toilet waits for calling signal from the elderly at standby room. When the calling signal is received, the toilet autonomously goes to the bedroom and approaches the elderly. After excreting, the toilet returns to the standby room and automatically disposes feces. This system is also equipped with analyzing function of feces for monitoring their health condition. We have developed a prototype of the toilet.

  The Japan Society of Mechanical Engineers, 17 Sep. 2008, The JSME Symposium on Welfare Engineering, 2008, 176 - 177, Japanese


• 1G2-2 Development of respiration monitoring system for home-care patients of respiratory diseases

  OKUBO Masahiko, IMAI Yohsuke, ISHIKAWA Takuji, HAYASAKA Tomoaki, YAMAGUCHI Takami

  A number of patients are suffering from respiratory diseases, such as dyspnea, sleep apnea syndrome (SAS), asthma and chronic obstructive pulmonary disease (COPD). These patients can be supported by early detection of symptom and administration of milder treatment. However, it is a serious burden for them and their family to care for their respiratory conditions in daily life. We propose a new home-care system for such patients. The system is an automatic inhaler control system based on continuous respiration monitoring. We employ a mask-type unit to install a measurement sensor for respiration together with an inhaler. Respiration is monitored using a thermocouple in the mask. Respiratory rate is measured by counting peaks of temperature change due to expiration and inspiration. The error of respiratory rate at rest in sitting posture was within 2% between the measurement and the reference. Based on the monitored data, the inhaler can be controlled automatically. Moreover, the information of respiration can be shared with family, hospital, and local supporters at a long distance through a computer network.

  The Japan Society of Mechanical Engineers, 17 Sep. 2008, The JSME Symposium on Welfare Engineering, 2008, 164 - 165, Japanese


• Availability of Adaptive Mesh Refinement method for the analysis of pulmonary airflow

  MIKI Takahito, IMAI Yohsuke, WADA Shigeo, IWAMURA Chihiro, ISHIKAWA Takuji, YAMAGUCHI Takami

  日本計算工学会, 19 May 2008, Proceedings of the conference on computational engineering and science, 13(2) (2), 827 - 830, Japanese


• A three-dimensional model of malaria-infected blood flow

  KONDO Hitoshi, IMAI Yohsuke, ISHIKAWA Takuji, TSUBOTA Ken-ichi, LIM C. T., YAMAGUCHI Takami

  日本計算工学会, 19 May 2008, Proceedings of the conference on computational engineering and science, 13(2) (2), 533 - 536, Japanese


• 126 Development of the self-propelled intelligent toilet

  UENO Sozo, KISHIMOTO Masamichi, HAYASAKA Tomoaki, MORI Daisuke, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 15 Mar. 2008, 講演論文集, 2008(43) (43), 53 - 54, Japanese


• 608 Measurement of physical load by a wearable thermometer system

  SUZUKI Yuta, KISHIMOTO Masamichi, MORI Daisuke, IMAI Yohsuke, MATSUKI Noriaki, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007(20) (20), 219 - 220, Japanese


• 101 Measurement of the blood flow in a microchannel with stenosis by confocal-micro-PTV system

  Rui Lima

  The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007(20) (20), 1 - 2, Japanese


• 105 DISPERSION OF RED BLOOD CELLS IN MICROCHANNELS : A CONFOCAL MICRO-PTV ASSESSMENT

  LIMA RUI, ISHIKAWA TAKUJI, IMAI YOHSUKE, FUJIWARA HIROKI, TAKEDA MOTOHIRO, MATSUKI NORIAKI, WADA SHIGEO, YAMAGUCHI TAKAMI

  The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007(20) (20), 9 - 10, English


• 210 Interactions between two swimming bacteria

  Ishikawa Takuji, Sekiya Go, Imai Yohsuke, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007(20) (20), 57 - 58, Japanese


• 118 Numerical Simulation of Saccular Aneurysm Formation in a Realistic Cerebral Artery Model

  SHIMOGONYA Yuji, ISHIKAWA Takuji, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 24 Jan. 2008, バイオエンジニアリング講演会講演論文集, 2007(20) (20), 35 - 36, Japanese


• 2304 Multiscale modeling of pulmonary airway system

  WADA Shigeo, NAKAMURA Masanori, MIKI Takahito, IMAI Yohsuke

  The Japan Society of Mechanical Engineers, 25 Nov. 2007, The Computational Mechanics Conference, 2007(20) (20), 189 - 190, Japanese


• 303 Application of a High-Order AMR Method to Pulmonary Airflow Simulations

  IMAI Yohsuke, MIKI Takahito, ISHIKAWA Takuji, NAKAMURA Masanori, WADA Shigeo, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 25 Nov. 2007, The Computational Mechanics Conference, 2007(20) (20), 583 - 584, Japanese


• 2211 A Simulation Study on Saccular Cerebral Aneurysm Formation Considering Biological Reactions

  SHIMOGONYA Yuji, ISHIKAWA Takuji, IMAI Yohsuke, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 25 Nov. 2007, The Computational Mechanics Conference, 2007(20) (20), 341 - 342, Japanese


• B208 Development of respiration measurement unit with wearable system

  OKUBO Masahiko, KISHIMOTO Masamichi, IMAI Yohsuke, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 05 Oct. 2007, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2007(18) (18), 127 - 128, Japanese


• Blood Cell Motions and Interactions in Microchannels

  LIMA Rui, ISHIKAWA Takuji, FUJIWARA Hiroki, TAKEDA Motohiro, IMAI Yohsuke, TSUBOTA Ken-ichi, WADA Shigeo, YAMAGUCHI Takami

  01 Jul. 2007, 可視化情報学会誌 = Journal of the Visualization Society of Japan, 27, 141 - 142, English


• Numerical simulation of cerebral aneurysm growth considering arterial adaptation

  下權谷 祐児, 今井 陽介, 石川 拓司

  日本計算工学会, May 2007, Proceedings of the conference on computational engineering and science, 12(1) (1), 213 - 216, Japanese


• 421 An adaptive mesh refinement method for numerical analysis of pulmonary airflow

  MIKI Takahito, IMAI Yohsuke, NAKAMURA Masanori, ISHIKAWA Takuji, YAMAGUCHI Takami, WADA Shigeo

  The Japan Society of Mechanical Engineers, 06 Jan. 2007, バイオエンジニアリング講演会講演論文集, 2006(19) (19), 140 - 141, Japanese


• 331 Meso-scale structure in a concentrated suspension of micro-organisms

  Ishikawa Takuji, Pedley T.J., Imai Yohsuke, Tsubota Ken-ichi, Yamaguchi Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2007, バイオエンジニアリング講演会講演論文集, 2006(19) (19), 318 - 319, Japanese


• 237 Numerical analysis of ATP transport in blood vessels

  SATO Kodai, IMAI Yohsuke, ISHIKAWA Takuji, COMERFORD Andrew, DAVID Tim, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 06 Jan. 2007, バイオエンジニアリング講演会講演論文集, 2006(19) (19), 298 - 299, Japanese


• A101 Development of a wearable system for an quantification measurement of human motions in daily life

  KISHIMOTO Masamichi, NAKAMURA Hiromi, YOSHIDA Toshihiko, MIZUNO Fumio, HAYASAKA Tomoaki, IMAI Yohsuke, TSUBOTA Ken-ichi, ISHIKAWA Takuji, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 10 Nov. 2006, Proceedings of the ... JSME Conference on Frontiers in Bioengineering, 2006(17) (17), 3 - 4, Japanese


• 527 The effect of arterial wall movement on the wall shear stress by a fluid-solid interaction computational study

  FUKUI Tomohiro, PARKER Kim H., IMAI Yohsuke, TSUBOTA Ken-ichi, ISHIKAWA Takuji, WADA Shigeo, YAMAGUCHI Takami

  The Japan Society of Mechanical Engineers, 02 Nov. 2006, The Computational Mechanics Conference, 2006(19) (19), 499 - 500, Japanese

• Frontiers in Computational Fluid-Structure Interaction and Flow Simulation: A Numerical Analysis of Rheology of Capsule Suspensions Using a GPU-Accelerated Boundary Element Method

  Yohsuke Imai, Daiki Matsunaga

  Joint work, Springer, Nov. 2018, English

  Scholarly book


• Integrated Nano-Biomechanics: 3.2 Gastric Motility and Flow in the Stomach

  Yohsuke Imai

  Joint work, Elsevier, Jul. 2018, English

  Scholarly book


• Integrated Nano-Biomechanics: 3.1 Dynamics of Swallowing

  Yohsuke Imai

  Joint work, Elsevier, Jul. 2018, English

  Scholarly book


• Integrated Nano-Biomechanics: 2.3 Cell Adhesion in Microvessels

  Yohsuke Imai

  Joint work, Elsevier, Jul. 2018, English

  Scholarly book


• Integrated Nano-Biomechanics

  Takami Yamaguchi, Takuji Ishikawa, Yohsuke Imai

  Joint editor, Elsevier, Jul. 2018, English

  Scholarly book


• Visualization and Simulation of Complex Flows in Biomedical Engineering

  R.Lima, Y.Imai, T.Ishikawa, M.S.N.Oliveira

  Joint editor, Springer, 2014, English

  Scholarly book

• Computation of complex physiological flows

  Yohsuke Imai

  Osaka University MEI-Center Summer School 2019, Aug. 2019, English, Suita, Japan, International conference

  [Invited]

  Invited oral presentation


• Development of a numerical model of whole-scale cerebral circulation

  Shunichi Ishida, Hiroki Kitade, Satoshi Ii, Naoki Takeishi, Yoshiyuki Watanabe, Yohsuke Imai, Shigeo Wada

  29th International Symposium on Cerebral Blood Flow, Metabolism, and Function, Jul. 2019, English, Yokohama, Japan, International conference

  Poster presentation


• Modeling cerebral vasculatures for analysis of the whole cerebral circulation

  Hiroki Kitade, Satoshi Ii, Shunichi Ishida, Yohsuke Imai, Shigeo Wada

  6th International Conference on Computational and Mathematical Biomedical Engineering, Jun. 2019, English, Sendai, Japan, International conference

  Poster presentation


• Hemorheology of dense suspension of red blood cells in a wall-bounded shear flow

  Naoki Takeishi, Marco E. Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt

  71st Annual Meeting of the APS Division of Fluid Dynamics, Nov. 2018, English, Atlanta, USA, International conference

  Oral presentation


• Relationship between gastric wall motility and mixing of liquid foods in the stomach

  Taimei Miyagawa, Shunichi Ishida, Gregory O'Grady, Leo Cheng, Yohsuke Imai

  8th World Congress on Biomechanics, Jul. 2018, English, Dublin, Ireland, International conference

  Poster presentation


• Perioperative hemodynamic changes in the patient with pulmonary arterial hypertension by use of thoracic 4D-flow MRI

  Hiroki Kamada, Hideki Ota, Yohsuke Imai, Kei Takase

  8th World Congress on Biomechanics, Jul. 2018, English, Dublin, Ireland, International conference

  Poster presentation


• Numerical simulation of cytoadhesion of red blood cells infected by Plasmodium falciparum

  Shunichi Ishida, Akihisa Ami, Yohsuke Imai

  8th World Congress on Biomechanics, Jul. 2018, English, Dublin, Ireland, International conference

  Invited oral presentation


• Effect of internal viscosity on suspension rheology of red blood cells

  Naoki Takeishi, Marco E. Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt

  Joint Meeting of the European Society for Clinical Hemorheology and Microcirculation, the International Society of Clinical Hemorheology, and the International Society of Biorheology, Jul. 2018, English, Krakow, Porland, International conference

  Oral presentation


• Cell adhesion during bullet and rolling motion in capillaries

  Naoki Takeishi, Yohsuke Imai, Roger Kamm

  8th World Congress on Biomechanics, Jul. 2018, English, Dublin, Ireland, International conference

  Invited oral presentation


• 微小循環の血液の流れを計算する

  IMAI YOHSUKE

  日本機械学会2018年度年次大会, 2018, Japanese, 吹田, Domestic conference

  Invited oral presentation


• 体の中の流れを計算する

  IMAI YOHSUKE

  第14回東北大学REDEEMシンポジウム, 2018, Japanese, 東京, Domestic conference

  Invited oral presentation


• 体の中の複雑な流れを計算する

  IMAI YOHSUKE

  第90回バイオメクフォーラム, 2018, Japanese, 豊中, Domestic conference

  Invited oral presentation


• 胃の中の流れを計算する

  IMAI YOHSUKE

  第50回生物機械システム研究会, 2018, Japanese, 豊中, Domestic conference

  Invited oral presentation

• 流体構造生化学連成解析によるニューロンの移動モードと大脳皮質形成の力学の解明

  今井 陽介, 林 周宏, 滝沢 研二

  日本学術振興会, 科学研究費助成事業, 基盤研究(A), 神戸大学, 05 Apr. 2021 - 31 Mar. 2024

  哺乳類の大脳皮質深部で誕生した神経細胞（ニューロン）は，三種類の移動モードを駆使して脳表層に到着し，インサイドアウトと呼ばれる六層構造の大脳皮質を形成する． 本研究の目的は，流体構造生化学連成解析とイン・ビボ細胞実験の統合的な手法によって，ニューロンの移動モードの変化とインサイドアウト構造の形成メカニズムを力学に基づいて明らかにすることである．そのための基盤計算技術として，細胞膜の固体力学，細胞質と細胞外の液体の流体力学，細胞接着タンパクと細胞骨格タンパクの生化学反応を連成するトランススケール流体構造生化学連成解析手法を開発する． ２０２１年度は，ニューロンの先導突起の挙動を再現できるトランススケール流体構造生化学連成解析手法の基礎を構築した．生体組織の成長理論をヒントに，局所的な生体膜の面積増加と薄膜の力学を連成する手法を開発した．非一様有理Ｂスプライン（ＮＵＲＢＳ）関数を用いて高次に表現した曲面に対し，細胞膜に対する代表的な構成則であるスカラックのひずみエネルギー関数（Skalak et al., Biophys. J., 1973）とヘルフリッヒの曲げエネルギー関数（Helfrich, Zeitschrift fur Naturforschung C, 1973）を弱形式で記述し，アイソジオメトリック解析を適用した．マッシュルーム形状の先導突起や長く伸びた先導突起を再現することに成功し，さらに，これらの先導突起の形状を記述する理論解を導出した．


• 薄く時間変化する生体建築部材の流体構造連成解析ーからだ建築のCAEの方法

  今井 陽介

  日本学術振興会, 科学研究費助成事業, 学術変革領域研究(A), 神戸大学, 10 Sep. 2021 - 31 Mar. 2023

  生体の組織を構成する建築部材は，多くの場合，繊維と膜と液体であり，例えば，上皮組織の管腔構造などが作られる．これらの建築部材に共通する特徴は，薄い構造であること，部材の数や形が時間変化すること，流体の中で建築作業が進行することである．本研究の目的は，生体建築部材から作られる生体組織のコンピュータ支援エンジニアリング（ＣＡＥ）の手法を開発することである．具体的には，建築部材の変形，成長，結合の変化を考慮して生体構造力学を数理モデル化し，Ｔ－スプライン曲面理論に基づくアイソジオメトリック解析を応用する流体構造連成計算手法を開発する．これを用いて，イン・ビボ実験で得られている螺旋形状の血管形成の再現を試みる． ２０２１年度は，生体建築部材の流体構造連成解析手法として，Ｔースプライン曲面理論に基づくアイソジオメトリック流体構造連成解析のフレームワークを開発した．この手法は曲面の高次表現に特徴があり，薄い構造の曲げ変形を高精度に計算することができる．管腔構造の生体組織に対し，成長を伴う管壁の構造力学を生体組織の成長理論とキルヒホッフ・ラブシェルを用いて定式化している．現在，この手法を用いて，血管を模擬した管腔構造に対する簡易的なパラメトリック解析を実施している．管腔構造が一次元的，二次元的，三次元的に座屈変形するパターンが得られており，それぞれの座屈変形パターンに至る条件を検討し，メカニズムを明らかにしようとしているところである．


• 腹部大動脈瘤の拡大速度を規定する病理組織学的因子に関する前向きコホート研究

  濱田 庸, 後藤 均, 赤松 大二朗, 今井 陽介, 菅原 宏文, 権田 幸祐

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 東北大学, 01 Apr. 2019 - 31 Mar. 2023

  昨年度に報告した通り現状ではコロナウイルス感染拡大により、研究計画遂行に大きな支障が生じている。今年度は遅れを取り戻すべく、昨年度と同様に大動脈瘤の拡大速度を規定する病理組織学的因子を解析するため、大動脈瘤血流シミレーション技術の確立と習得、大動脈瘤症例の瘤径の継時的変化の観察、また、大動脈瘤壁の組織サンプルの蓄積、得た技術をもとにした大動脈瘤破裂症例の血流シミレーション等を行う予定であった。しかしながら、今年度も引き続いてコロナ感染は拡大に歯止めがかからず、数回の波も出現した。研究代表者が所属するのが大規模医療機関である事から、大動脈瘤血流シミレーションソフトを開発する予定であった神戸大学との共同研究が、人的交流を含めて困難である状況は変わっていない。それゆえ、現在に至るまでもシミレーションの基盤を確立する段階に至っていない。オンラインミーティングを活用もしているものの、オンラインではその特性からプライバシーに配慮した患者データのやり取りには限界があり、それを元にしたシミレーションデモは行っているものの、数名程度にとどまっている。また、引き続きコロナウイルス感染症の影響で、そもそも大動脈瘤の新規受診症例が減少していることは変わりなく、また、ICU病床・手術室の利用制限も同様であるため、大動脈瘤手術症例の蓄積を行う事が困難である事にも変わりがない。したがって今年度も研究実績は、残念ながらほぼ得られていない。コロナウイルス感染症は収束の糸口が若干見えてきた感があるが、残りの研究期間を考えると、現時点で当初予定していた研究遂行は非常に困難であると言わざるを得ない。従って、次年度最終年度を迎えるにあたり、研究期間の延長申請を行う事を考えている。


• Fluid-Structure Interaction Modeling of Heart Valves and Red Blood Cells

  滝沢 研二, 今井 陽介

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Waseda University, 01 Apr. 2018 - 31 Mar. 2023

  心臓弁の開閉に伴い、その内側を流れる赤血球を含む血液は1)流速3 m/sから急激に静止する強い非定常性、2)弁尖同士に挟まれるという 特異性がある。そのため、実験での観測が極めて困難であり、従来の数値計算でも再現できない。従って、弁の開閉やそれに伴う血流動態といった物理の解明には至っていない。本研究では、心臓の弁近傍の血流動態の解明に向け、流体構造連成解析手法を拡張する。具体的には、弁を 含む流体構造連成問題、高速流れ中の赤血球挙動、心臓弁開閉時の赤血球挙動の数値計算手法を順に構築する。統合した手法を用い、赤血球が 弁の開閉時にどのように振る舞うかを詳細に再現することで、血流動態を明らかにする。これにより、心臓弁の機能を損なう疾患の予防・治療 方法に、力学的視点から新たな指針を提示することを目的としている。
  本研究では、心臓弁の開閉が起こるようなトポロジー変化が起きる空間を占める流体を、物体適合格子を用いて計算する手法を構築している。この方法は従来の信頼のある解析手法を損なうことなく同時にトポロジー変化も考慮できる方法で、トポロジー変化に特化した手法に比べ信頼性が高い。この方法による計算から、弁が閉じる際に流速は必ずしも徐々に小さくなるわけではないことが示されており、開閉時に生じる速度境界層を捉えることの重要性などがわかる。この事実から、他手法では議論しにくい開閉近傍の現象解明を数値計算により検証ができるようになっている。また赤血球を含む流体解析は多く場合、その影響度合いの高い毛細血管のような低速の箇所であるが、本研究では速度の高い領域での赤血球挙動を議論するために、Navier-Stokes方程式に基づく流体と赤血球の連成問題について取り組んでいる。


• An integrated analysis of biomechanics of cytokinesis: in vitro experiment and computer simulation

  Imai Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 30 Jul. 2020 - 31 Mar. 2022

  In cells, two talins form a homodimer, connecting to each other at the C-terminus dimerization domain. We hypothesized that an alteration in the talin dimer structure changes the dynamics of cytokinesis. To test the hypothesis, we performed a three-dimensional time-lapse imaging of MDA-MB-231 cells, expressing talin-GFP which forms heterodimers with endogenous talin. We show that the cytokinesis orientation was changed to more oblique rather than horizontal by expressing talin-GFP.


• ニューロンの四つの移動モードの数理・計算モデルの開発

  今井 陽介

  日本学術振興会, 科学研究費助成事業, 新学術領域研究(研究領域提案型), 神戸大学, 01 Apr. 2019 - 31 Mar. 2021

  本研究課題の目的は，大脳新皮質を構成する興奮性ニューロンの四つの移動モードに対する数理モデルを開発し，大脳新皮質の形成過程を数値解析するための基盤技術を構築することである．大脳新皮質のインサイドアウト構造の形成にはリーリンと呼ばれる分子が必要であり，リーリンはニューロンの四つの移動モード全ての制御に関わっていることが分かっている．ここでは，リーリンによる細胞骨格分子，細胞接着分子の制御に着目し，その効果を細胞骨格分子の重合・脱重合速度の変化，あるいは細胞接着分子の結合・離脱速度の変化としてモデル化する．大規模な数値解析によってこれらのパラメータの変化とニューロンの形態・挙動の変化の関係を力学法則に基づき定量的に理解する．ここでは，細胞を一様な非圧縮の粘弾性体と仮定し，細胞外部の粘性流体との流体構造連成問題としてモデル化した．細胞接着分子のリガンドレセプタ結合にはスリップボンドモデルを採用し，モンテカルロ法を用いて計算した．細胞表面にリガンド，細胞外部の足場にレセプタを分布させ，これらの結合による接着力を埋め込み境界法を用いて流体構造連成計算と連立した．ニューロンのモデルにほとんど同じ物性値を設定し，繊維のネットワーク状の足場とロッド状の足場にそれぞれ配置した．繊維のネットワーク状の足場に配置したニューロンは多極性移動でみられるような挙動を示した．一方，ロッド状の足場に配置したニューロンはロコモーションでみられるような挙動を示した．これらの結果から，多極性移動からロコモーションへの移動モードの変化では，細胞接着の足場となる細胞環境の変化が主な要因であり，細胞の力学特性や生化学特性の変化は二次的な効果となる可能性が示唆された．


• Development of computational biomechanics of the gastrointestinal system

  Imai Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), 01 Apr. 2017 - 31 Mar. 2021

  We developed a numerical model of gastric flow using computational fluid dynamics, medical imaging, and electrophysiology. We showed that impaired coordination between antral contraction and pyloric closure can result in delayed gastric emptying and bile reflux. We also found that slow wave velocity changed with interstitial cells of Cajal loss and aging, resulting in changes in emptying rate.


• Upgrading Microbial Biomechanics

  Ishikawa Takuji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Tohoku University, 01 Apr. 2017 - 31 Mar. 2021

  By using an original method that carefully builds up physical laws from the nanoscale to the macroscale, we have clarified the behavior and biological functions of sperm, microalgae, ciliates, E. coli, yeast, and other organisms under mechanical environments. We succeeded in analyzing through the scale hierarchy from the movement of ciliary axonemes driven by molecular motors, synchronization of flagellar movement, swimming and biological responses of ciliates with many flagella, two-body interactions and cooperative swimming, rheology and diffusion properties as a continuum, cell growth and accumulation, and so on. These results were published in a total of 48 peer-reviewed journal articles, including two in PNAS, one in Science Adv, and six in J Fluid Mech. In addition, 8 press releases were issued to widely publicize the research results.


• Physiological fluid mechanics of intestine

  Imai Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 29 Jun. 2018 - 31 Mar. 2020

  We have developed a numerical model of “Rectosigmoid brake”. We constructed a geometry model of the large intestine based on medical imaging data. We gave retrograde waves to the geometry model, where the waves initiated at the rectosigmoid, and travelled along the sigmoid colon. We applied the cumulant lattice Boltzmann method and the adaptive subdomain method for computational fluid dynamics simulation. We showed that pressure at the rectum was decreased by the retrograde waves.


• The recurrent laryngeal nerve search system to detect nerve saltatory conduction by magnetic stimulation in esophageal cancer surgery

  SHIMIZU Kazuo

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Tohoku University, 01 Apr. 2016 - 31 Mar. 2019

  A reliable method is required for the search of recurrent laryngeal nerve during esophagectomy. We found the following new findings using the sciatic nerve of the small animals such as rat and rabitt. First, the occurrence interval of saltatory conduction is about 45 mm. Second, it is possible to distinguish conduction between nerve or other tissue by performing continuous pulse stimulation using the firing characteristics of Na+ channel in the Ranvier's constriction. Unfortunately, even using the lock-in amplifier, it could not detect the firing of the Na+ channel in the Ranvier's constriction by magnetic sensor. In addition, it could not realize the saltatory conduction by continuous pulse stimulation using magnetism. However, a new finding was obtained that the saltatory conduction was occurred jumping over several Ranvier's constriction.


• Advances in cell suspension mechanics based on the hierarchy structure

  Ishikawa Takuji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Tohoku University, 01 Apr. 2014 - 31 Mar. 2017

  In this project, we have succeeded to construct a world leading ‘cell suspension mechanics based on the hierarchy structure’ by combining experiment, theory and numerical simulation. We have clarified many phenomena from nano to macro scale using various cells such as algae, bacteria and blood. Then, the obtained knowledge was utilized to develop devices for engineering and biomedical use. The results have been published as 30 peer review journal papers.


• Integrated nano-biomechanics

  YAMAGUCHI Takami, ISHIKAWA Takuji, UENO Hironori, MIZUNO Fumio, OMORI Toshihiro, MATSUKI Noriaki, TANAKA Tetsu, SHIMOGONYA Yuji, NIX Stephanie, NUMAYAMA Keiko, IMAI Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Specially Promoted Research, Tohoku University, 2013 - 2017

  We have established integrated nano-biomechanics by modeling multi-scale physical and biomedical phenomena from the molecular level. By using the established model, we succeeded to numerically simulate various diseases, such as an infectious disease, and developed novel methodologies for medical diagnosis and treatments based on quantitative predictions. Besides, we developed biochips to separate or detect cancer cells and bacteria. These findings have been published as 50 peer reviewed journal papers.


• 実験的に抽出された分子反応パラメータを導入したマラリア感染赤血球モデルの開発

  今井 陽介

  日本学術振興会, 科学研究費助成事業, 新学術領域研究(研究領域提案型), 東北大学, 01 Apr. 2014 - 31 Mar. 2016

  マラリアに感染した赤血球は膜表面に接着タンパクを発現する．この分子反応の発現によりマラリア感染赤血球は微小血管内に接着し，周囲の赤血球を巻き込んだ組織レベルの微小循環障害を引き起こす． 細胞の力学と生化学を連立する計算力学モデルを開発し，接着分子の生化学特性とマラリア感染赤血球挙動の関係に対する大規模パラメトリック計算を実施した．まず単体のマラリア感染赤血球挙動の計算を実施し，次に，多数の正常赤血球と相互作用する微小循環内の挙動を計算することで総合的に検討を行った．血管内皮細胞上にTSPやCD36がレセプタとして存在している場合，マラリア感染赤血球は定常接着をすると報告されているが，このような定常接着は離脱頻度が1/s以下の場合に生じることを明らかにした．またレセプタとしてICAM-1が存在する場合，マラリア感染赤血球は回転運動をすることが知られているが，ICAM-1は結合に作用する力にほとんど依存しない結合特性を有することを明らかにした． また，開発した計算力学モデルをより一般的なカプセル懸濁液のレオロジー解析や白血球・腫瘍細胞の流動・接着の問題に応用した．マラリアと同様，白血球の接着は生体防御において，腫瘍細胞の接着はがん転移において重要な過程であり，古くから血管壁面の「Rolling」や定常接着が調べられてきた．我々はセレクチンを発現した毛細血管内の細胞挙動を計算し，毛細血管径が細胞径より小さくなると，細胞は管の中央を移動する「Bullet」挙動を示すことを明らかにした．このときリガンド‐レセプタ結合によって細胞の移動速度は著しく減少し，レセプタ密度が十分低い領域においても定常接着とみなせるような速度となることを示した．


• A numerical study of functional dyspepsia

  Imai Yohsuke, MIYAGAWA Taimei

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Tohoku University, 01 Apr. 2014 - 31 Mar. 2016

  To understand the relationship between the peristaltic contraction and the flow in the stomach, we have developed a numerical model of gastric flow. This model is based on a multi-phase flow modeling, an anatomically realistic geometry of the stomach, and a parametric model of peristaltic contractions. Antral recirculation is generated in the stomach. Our result shows that when peristaltic wave velocity increases, the strength of antral recirculation increases, resulting in enhancement of gastric mixing. We also show that mixing strength per one contraction becomes lower when the initiation period of peristaltic contractions is shorter.


• Computational biomechanics of interactions between cells and their environment in microcirculation

  IMAI Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Tohoku University, 01 Apr. 2012 - 31 Mar. 2015

  We developed a graphics processing unit computing method for simulating cellular flows in microcirculation. Fluid mechanics of plasma and cytoplasm is coupled with solid mechanics of membrane, and ligand-receptor bindings for cell adhesion. We quantified the deformation of red blood cells and the rheology of red blood cell suspension. We also analyzed margination, rolling motion and firm adhesion of white blood cells and circulating tumor cells in microcirculatory blood flows.


• 生体流れに関わる疾患の診断・治療・予防のための計算ナノバイオメカニクスの新展開

  山口 隆美, 大森 俊宏, 沼山 恵子, 今井 陽介, 上野 裕則

  日本学術振興会, 科学研究費助成事業, 基盤研究(S), 東北大学, 31 May 2011 - 31 Mar. 2014

  平成25年度（平成25年4月1日～平成25年4月25日）の研究内容は，細胞スケールにおける生体力学および分子生物学の融合を目指したシミュレーション技術の開発であり，主な成果は以下のとおりである． (1) 平成24年度に開発した細胞の接着に関連するligand-receptor結合の計算力学モデルについて，これを格子ボルツマン法と有限要素法に基づく流体－膜連成計算手法へと導入し，血小板血栓形成，マラリア感染赤血球の血管内皮細胞上の回転運動，がん細胞の血管内皮細胞への接着を対象としたシミュレーション手法の開発に着手した． (2) 平成24年度にクライオ電子線トモグラフィー法を用いて解明した気管繊毛の三次元内部構造を考慮し，ダイニン分子の滑り運動に由来する個々の気管繊毛の運動と，これによって駆動される周囲の流れ場の連成シミュレーション手法の開発に着手した． (3) 平成24年度までに赤血球の希薄・準希薄懸濁液を対象として，境界要素法と有限要素法に基づく流体－膜連成計算手法を開発し，循環器のマクロスケールの解析で必要となる粒子応力テンソル，自己拡散テンソルを算出している．これを赤血球濃厚懸濁液へと拡張するため，細胞濃厚懸濁液を対象とした大規模GPUシミュレーション手法の開発に着手した． (4) 平成24年度に開発した実形状の胃に対する液体食物流動（食物攪拌）の計算力学モデルについて，これを相の異なる液体や固体運動を連成する手法へと改良し，様々な食物および胃液などの流動を解析するための計算力学モデルの開発に着手した．


• Large-scale simulations for gas-liquid two-phase flow-structure interaction using GPU supercomputer

  AOKI Takayuki, KOBAYASHI Hiromichi, IMAI Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Tokyo Institute of Technology, 01 Apr. 2011 - 31 Mar. 2014

  In spite of unknown complex dynamics of two-phase flows including gas-liquid interfaces, it is hard to study them with high spatial resolution by numerical computation due to quit less efficiency of parallel computing. By using a large number of GPUs equipped with high computational performance, we have developed a numerical simulator of gas-liquid two-phase flows with high resolution by introducing a new CLSVOF (Coupled Level Set with Volume of Fluid) method, a Pressure Poisson solver of Multi-grid preconditioned BiCGSTAB and IBM (Immersed Boundary Method). In order to get high parallel scalability, an overlapping technique between computation and communication is indispensable.


• Development of computational biomechanics of gastric mixing

  IMAI Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Tohoku University, 2008 - 2010

  We developed a computational fluid dynamics model of gastric mixing. Moving wall condition of antral contraction wave and free-surface condition of gastric gas were given as boundary conditions of the numerical model. We investigated the effects of physiological conditions such as the viscosity and volume of food bolus and the antral contraction wave pattern on the mixing efficiency and fluid stress in the stomach.


• Computational nano-biomechanics for the diagnosis, treatment, and prevention of diseases of blood, circulatory, and digestive organs

  YAMAGUCHI Takami, ISHIKAWA Takuji, IMAI Yohsuke, MORI Daisuke, MATSUKI Noriaki, MIZUNO Fumio

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Tohoku University, 2007 - 2010

  We have developed computational nano-biomechanics for the diagnosis, treatment, and prevention of diseases of blood, circulatory, and digestive organs. We proposed a novel hemodynamic index to predict the initiation of cerebral aneurysms. A numerical model of microvascular blood flow was developed for simulating microvascular occlusion in malaria infection, and thrombogenesis. A model of swimming microorganisms was also developed for analyzing intestinal flora.


• Development of Multi-Purpose CFD Core using Multi-Moment Scheme

  AOKI Takayuki, UTSUMI Takayuki, IMAI Yohsuke, KOBAYASHI Hiromichi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Tokyo Institute of Technology, 2007 - 2009

  次世代の流体解析(CFD)において、流体方程式を格子点上の値、線積分平均値、面積分、体積積分平均値を従属変数として解く多モーメント手法が高精度かつ安定な計算を行うために有効である。直交格子に適合細分化格子法を導入することで解像度制御を行い、保存形IDO法による圧縮性流体計算、非圧縮性流体計算、乱流計算、多相流計算などの様々な流体問題に適用できる高性能な計算コアを開発する。


• 消化管内容物輸送シミュレータによる消化器系疾患の病態生理研究

  今井 陽介

  日本学術振興会, 科学研究費助成事業, 若手研究(スタートアップ), 東北大学, 2006 - 2007

  消化管内ガス,食塊,消化液の混相流問題では,領域によって解像するべき流れのスケールが大きく異なる.例えば気相・液相の界面において適切な格子サイズを用いなければ,界面近傍の解が拡散的になる.さらに蠕動運動によって生じる胃壁の移動境界や将来的に導入する食塊の粒子成分の近傍などにおいても同様に,局所的に高解像度の格子が要求される.任意領域の格子解像度を局所的に変化させるAdaptive Mesh Refinement(AMR)法はこのための有望な解決法であるが,粗い格子と細かい格子の境界において流体変数の補間や非等間隔の離散化が必要となるため,2次精度までの手法しか報告されていなかった.Interpolated Differential Operator(IDO)法を適用し,3次元Navier-Stokes方程式に対して4次精度の定式化を行い,医用画像ベースの生体内流動問題に適用し,本手法によって高精度なマルチスケール解析が可能であることを確認した.AMR法を用いた場合,非圧縮性流体の半陰的解法に必要となる圧力のPoisson方程式の係数行列が著しく不規則になるため収束性が悪化する.IDO法の係数行列は非対称な疎行列であるが,従来の差分法と同様,Algebraic Multi-grid(AMG)法を適用することでこれを改善できることを確認した.胃内部の食塊流動問題へ適用するための界面追跡および捕獲法として,Constrained Interpolated Profile-Conservative Semi-Lagrangian3(CIP-CSL3)法およびTangent of Hyperbola for Interface Capturing(THINC)法をIDO法に適合させた,Semi-Lagrange法であるこれらの手法をEuler法として定式化し,記述が簡易になる一方で従来の方法と同等または優れた界面捕獲法となりえることを確認した.2次元の胃内部食塊流動問題に適用し,消化管内ガスの影響に関する基礎的知見を得た.


• Mechanism of the formation, destruction, and movement of thrombi responsible for ischemia of vital organs

  YAMAGUCHI Takami, WADA Shigeo, TSUBOTA Ken-ichi, ISHIKAWA Takuji, IMAI Yohsuke

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Tohoku University, 2004 - 2006

  We investigated multi-scale behaviors of the formation, destruction, and movement of thrombi under blood flow that are responsible for ischemia of vital organs by using computer simulation and in vitro experiments based on biomechanics. We carried out computer simulations based on a Stokesian Dynamics method and a particle method to characterize the relationships between physiological and fluid mechanical factors in platelet aggregation under blood flow. We determined the relationships between deformation of red blood cells and apparent blood flow resistance. The result indicated that interactions among blood cells play a pivotal role in blood flow properties. It was also shown that biological/mechanical interactions among different types of blood cells determine thrombogenesis process. We established an in vitro quantitative measurement of blood flow through micro channel with micro PIV system, and obtained a spatiotemporal velocity fluctuation in blood flow that depends on hemaetocrit values. This indicated that mechanical interaction among blood cells governs blood flow properties. We proposed a large-scale computer simulation model of flow of red blood cells with the Earth Simulator, and established mathematical formulae of blood flow that can explain hierarchical mechanical behaviors of blood flows from the scale of blood cells (jam) to large vessel (cm). We also developed an integrated computer model of the left ventricle and the aorta, and demonstrated that the model is practically useful in detailed evaluation of the vortex and stagnation, which greatly affects thrombogenesis, in heart and large arteries.


• Study on Mechanisms of the Development of Cardiovascular and Cerebrovascular Diseases

  YAMAGUCHI Takami, ISHIKAWA Takuji, TSUBOTA Ken-ichi, IMAI Yohsuke, WADA Shigeo

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Tohoku University, 2003 - 2006

  Human cardiovascular system is always under the integrated nervous and Humoral control of the whole body, i.e., in homeostasis. Multiple feedback mechanisms with mutual interactions among systems, organs, and even tissues provide integrated control of the entire body. These control mechanisms have different spatial coverage, from the micro- to macroscale, and different time constants, from nanoseconds to decades. Based on this consideration, we investigated the cardiovascular system over micro to macro levels by using conjugated computational mechanics analyzing fluid and solid interactions in the research project. We studied blood flow in the aorta with beating left ventricle as a power source, ATP transport in a cerebral artery with aneurysm, the progress of cerebral aneurysm due to adaptation of arterial wall, the blood flow considering more than 16 thousands of red blood cells' motion, and platelets aggregation in blood flow using a particle method developed for the purpose. The aortic blood flow showed independence from the intraventricular vortices formation downstream from the aortic arch, where the three dimensional configuration of the aorta determined the global flow structure. Transport and distribution of ATP molecule was found to be strongly dependent on the relative position of aneurysms to the mother arteries. The particle method developed in the present study showed its potential to represent the microscale aggregation process of the platelet in the blood flow. In considering clinical applications, however, one needs to include more about biological complexities in the analysis of blood flow, especially with respect to disease processes. A disease is not just a failure of machine. It is an outcome of complex interactions among multi-layered systems and subsystems. We expect that biological phenomena, including disease processes, will be clarified in the future by integrating new understandings of macroscale and microscale hemodynamics.

• 数値計算方法，プログラムおよび記録媒体

  青木尊之, 今井陽介

  特願2005-142404, 16 May 2005, 国立大学法人東京工業大学, 特開2006-318355, 24 Nov. 2006

  Patent right