Research activity information

• Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen.

  Io Horikawa, Hirotaka Nagai, Masayuki Taniguchi, Guowei Chen, Masakazu Shinohara, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Shiho Kitaoka, Tomoyuki Furuyashiki

  Despite the importance of lipid mediators in stress and depression and their link to inflammation, the influence of stress on these mediators and their role in inflammation is not fully understood. This study used RNA-seq, LC-MS/MS, and flow cytometry analyses in a mouse model subjected to chronic social defeat stress to explore the effects of acute and chronic stress on lipid mediators, gene expression, and cell population in the bone marrow and spleen. In the bone marrow, chronic stress induced a sustained transition from lymphoid to myeloid cells, accompanied by corresponding changes in gene expression. This change was associated with decreased levels of 15-deoxy-d12,14-prostaglandin J2, a lipid mediator that inhibits inflammation. In the spleen, chronic stress also induced a lymphoid-to-myeloid transition, albeit transiently, alongside gene expression changes indicative of extramedullary hematopoiesis. These changes were linked to lower levels of 12-HEPE and resolvins, both critical for inhibiting and resolving inflammation. Our findings highlight the significant role of anti-inflammatory and pro-resolving lipid mediators in the immune responses induced by chronic stress in the bone marrow and spleen. This study paves the way for understanding how these lipid mediators contribute to the immune mechanisms of stress and depression.

  Apr. 2024, Journal of pharmacological sciences, 154(4) (4), 279 - 293, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A mysterious triangle of blood, bones, and nerves.

  Noboru Asada, Yoshio Katayama

  The relationship between bone tissue and bone marrow, which is responsible for hematopoiesis, is inseparable. Osteoblasts and osteocytes, which produce and consist of bone tissue, regulate the function of hematopoietic stem cells (HSC), the ancestors of all hematopoietic cells in the bone marrow. The peripheral nervous system finely regulates bone remodeling in bone tissue and modulates HSC function within the bone marrow, either directly or indirectly via modification of the HSC niche function. Peripheral nerve signals also play an important role in the development and progression of malignant tumors (including hematopoietic tumors) and normal tissues, and peripheral nerve control is emerging as a potential new therapeutic target. In this review, we summarize recent findings on the linkage among blood system, bone tissue, and peripheral nerves.

  Feb. 2023, Journal of bone and mineral metabolism, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Neutrophil mobilization is crucial for chronic social stress-induced behavioral alterations in mice

  Toshihiro Hisasue, Qing Zhu, Yuka Ishikawa, Taro Kato, Shinichi Ishii, Yoshio Katayama, Yuta Yamaguchi, Ryota Shinohara, Tomoyuki Furuyashiki

  Japanese Pharmacological Society, 2023, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97, 3 - B

  Scientific journal


• Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.

  Kentaro Minagawa, Kanako Wakahashi, Chie Fukui, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Akiko Sada, Shinichiro Nishikawa, Noboru Asada, Yoshio Katayama, Toshimitsu Matsui

  Loss of TFL, found in several types of lymphoma, induces excessive CXCL13 secretion through RNA dysregulation contributing to body weight loss and early death in lymphoma model mice. Follicular lymphoma (FL) is associated with overexpressed BCL-2 and other genetic aberrations, including 6q-. We identified a novel gene on 6q25, "Transformed follicular lymphoma (TFL)," from a transformed FL. TFL regulates several cytokines via mRNA degradation, which has been suggested to underlie resolving inflammation. Fluorescence in situ hybridization revealed a deletion of TFL occurred in 13.6% of various B-cell lymphoma samples. We developed VavP-bcl2 transgenic, TFL deficit mice (Bcl2-Tg/Tfl -/-) to seek how TFL affects disease progression in this lymphoma model. While Bcl2-Tg mice developed lymphadenopathy and died around 50 weeks, Bcl2-Tg/Tfl -/- mice lost body weight around 30 weeks and died about 20 weeks earlier than Bcl2-Tg mice. Furthermore, we found a unique B220-IgM+ cell population in the bone marrow of Bcl2-Tg mice. cDNA array in this population revealed that Cxcl13 mRNA in Bcl2-Tg/Tfl -/- mice expressed significantly higher than Bcl2-Tg mice. In addition, bone marrow extracellular fluid and serum showed an extremely high Cxcl13 concentration in Bcl2-Tg/Tfl -/- mice. Among bone marrow cells, the B220-IgM+ fraction was the main producer of Cxcl13 in culture. A reporter assay demonstrated TFL regulates CXCL-13 via induction of 3'UTR mRNA degradation in B lineage cells. These data suggest Tfl regulates Cxcl13 in B220-IgM+ cells in the bone marrow, and a very high concentration of serum Cxcl13 arising from these cells may contribute to early death in lymphoma-bearing mice. Since several reports have suggested the association of CXCL13 expression with lymphoma, these findings provide new insights into cytokine regulation via TFL in lymphoma.

  2023, Frontiers in immunology, 14, 1197112 - 1197112, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• FGF-23 from erythroblasts promotes hematopoietic progenitor mobilization.

  Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Noboru Asada, Yuko Kawano, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Yukio Nakamura, Seiya Mizuno, Satoru Takahashi, Toshimitsu Matsui, Yoshio Katayama

  Fibroblast growth factor 23 (FGF-23) hormone is produced by bone-embedded osteocytes and regulates phosphate homeostasis in kidneys. We found that administration of granulocyte colony-stimulating factor (G-CSF) to mice induced a rapid, substantial increase in FGF-23 messenger RNA in bone marrow (BM) cells. This increase originated mainly from CD45-Ter119+CD71+ erythroblasts. FGF-23 protein in BM extracellular fluid was markedly increased during G-CSF-induced hematopoietic progenitor cell (HPC) mobilization, but remained stable in the blood, with no change in the phosphate level. Consistent with the BM hypoxia induced by G-CSF, low oxygen concentration induced FGF-23 release from human erythroblast HUDEP-2 cells in vitro. The efficient mobilization induced by G-CSF decreased drastically in both FGF-23-/- and chimeric mice with FGF-23 deficiency, only in hematopoietic cells, but increased in osteocyte-specific FGF-23-/- mice. This finding suggests that erythroblast-derived, but not bone-derived, FGF-23 is needed to release HPCs from BM into the circulation. Mechanistically, FGF-23 did not influence CXCL-12 binding to CXCR-4 on progenitors but interfered with their transwell migration toward CXCL-12, which was canceled by FGF receptor inhibitors. These results suggest that BM erythroblasts facilitate G-CSF-induced HPC mobilization via FGF-23 production as an intrinsic suppressor of chemoattraction.

  Corresponding, Mar. 2021, Blood, 137(11) (11), 1457 - 1467, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mobilization efficiency is critically regulated by fat via marrow PPARδ.

  Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama

  The mobilization efficiency of hematopoietic stem/progenitor cells from bone marrow (BM) to circulation by granulocyte colony-stimulating factor (G-CSF) is dramatically dispersed in humans and mice with no mechanistic lead for poor mobilizers. The regulatory mechanism for mobilization efficiency by dietary fat was assessed in mice. Fat-free diet (FFD) for 2 weeks greatly increased mobilization compared to normal diet (ND). The BM mRNA level of peroxisome proliferator-activated receptor δ (PPARδ), a receptor for lipid mediators, was markedly up-regulated by G-CSF in mice fed with ND and displayed strong positive correlation with widely scattered mobilization efficiency. It was hypothesized that BM fat ligand for PPARδ might inhibit mobilization. The PPARδ agonist inhibited mobilization in mice fed with ND and enhanced mobilization by FFD. Treatment with the PPARδ antagonist and chimeric mice with PPARδ+/- BM showed enhanced mobilization. Immunohistochemical staining and flow cytometry revealed that BM PPARδ expression was enhanced by G-CSF mainly in mature/immature neutrophils. BM lipid mediator analysis revealed that G-CSF treatment and FFD resulted in the exhaustion of ω3-polyunsaturated fatty acids such as eicosapentaenoic acid (EPA). EPA induced the up-regulation of genes downstream of PPARδ, such as carnitine palmitoyltransferase-1α and angiopoietin-like protein 4 (Angptl4), in mature/immature neutrophils in vitro and inhibited enhanced mobilization in mice fed with FFD in vivo. Treatment of wild-type mice with the anti-Angptl4 antibody enhanced mobilization together with BM vascular permeability. Collectively, PPARδ signaling in BM mature/immature neutrophils induced by dietary fatty acids negatively regulates mobilization, at least partially, via Angptl4 production.

  Corresponding, Feb. 2021, Haematologica, 106(6) (6), 1671 - 1683, English, International magazine, Co-authored internationally

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference in response.

  Yuka Ishikawa, Shiho Kitaoka, Yuko Kawano, Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Taro Kato, Yoshio Katayama, Tomoyuki Furuyashiki

  BACKGROUND AND PURPOSE: Inflammation has been associated with stress-related mental disturbances. Rodent studies have reported that blood-borne cytokines are crucial for stress-induced changes in emotional behaviours. However, the roles and regulation of leukocytes in chronic stress remain unclear. EXPERIMENTAL APPROACH: Adult male C57BL/6N mice were subjected to repeated social defeat stress (R-SDS) with two protocols which differed in stress durations, stress cycles, and housing conditions, followed by the social interaction test. The numbers of leukocyte subsets in the bone marrow, spleen, and blood were determined by flow cytometry shortly after or several days after R-SDS. These leukocyte changes were studied in two strains of mice with different stress susceptibility, C57BL/6N and BALB/c mice. KEY RESULTS: R-SDS with both protocols similarly induced social avoidance in C57BL/6N mice. In the bone marrow, neutrophils and monocytes were increased, and T cells, B cells, NK cells, and dendritic cells were decreased with both protocols. In the blood, neutrophils and monocytes were increased with both protocols, whereas T cells, B cells, NK cells, and dendritic cells were decreased with one of these. Neutrophils and monocytes were also increased in the spleen. Changes in the bone marrow and increased levels of circulating neutrophils were maintained for 6 days after R-SDS. BALB/c mice showed greater social avoidance and increase in circulating neutrophils than C57BL/6N mice. CONCLUSION AND IMPLICATIONS: In two strains of mice, chronic stress induced neutrophil mobilization and its maintenance. These effects were strain-related and may contribute to the pathology of mental illness. LINKED ARTICLES: This article is part of a themed issue on Neurochemistry in Japan. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.4/issuetoc.

  Feb. 2021, British journal of pharmacology, 178(4) (4), 827 - 844, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• [Marrowlogy: a key aspect for the deep understanding of clinical hematology].

  Yoshio Katayama

  Mammals have developed bone marrow (BM) inside the bone tissue because of evolution. Now, it appears that bone tissue displays functional communication with the hematopoietic system. Osteoblast lineage cells serve as a part of the microenvironment for immature hematopoietic cells, whereas mature hematopoietic cells play important roles in regulating osteoblast activity. The nervous system maintains the balance between the hematopoietic and skeletal systems. An understanding of the multiple-organ network that exists between the BM and other systems is useful to elucidate phenomena in clinical hematology and even in other fields, an area which I propose to call "marrowlogy."

  2020, [Rinsho ketsueki] The Japanese journal of clinical hematology, 61(9) (9), 1058 - 1063, Japanese, Domestic magazine

  Scientific journal


• PTクロスミキシング試験が有用であった後天性第V因子インヒビターの一症例

  山下 智江, 下村 大樹, 野上 恵嗣, 中町 祐司, 井上 武, 片山 義雄, 河野 誠司, 三枝 淳

  (一社)日本検査血液学会, Jun. 2019, 日本検査血液学会雑誌, 20(学術集会) (学術集会), S192 - S192, Japanese

  [Refereed]


• Clinical effects of recombinant thrombomodulin and defibrotide on sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation.

  Kimikazu Yakushijin, Takayuki Ikezoe, Chikako Ohwada, Kazuko Kudo, Hiroshi Okamura, Hiroaki Goto, Hiromasa Yabe, Atsushi Yasumoto, Hideyuki Kuwabara, Shiro Fujii, Kumiko Kagawa, Masao Ogata, Yasushi Onishi, Akio Kohno, Koichi Watamoto, Nobuhiko Uoshima, Daisuke Nakamura, Shuichi Ota, Yasunori Ueda, Tatsuo Oyake, Kazutoshi Koike, Ishikazu Mizuno, Hiroatsu Iida, Yoshio Katayama, Hiroatsu Ago, Koji Kato, Atsuo Okamura, Atsushi Kikuta, Takahiro Fukuda

  Sinusoidal obstruction syndrome (SOS) is a lethal complication after hematopoietic stem cell transplantation (HSCT). Defibrotide (DF) is the only drug internationally recommended for SOS treatment in Western countries. Recombinant human soluble thrombomodulin (rhTM), which is promising for the treatment of patients with disseminated intravascular coagulation, is also reported to be potentially effective for SOS. To clarify the safety and efficacy of DF and rhTM, we conducted a retrospective survey of these agents in Japan. Data from 65 patients who underwent allogeneic HSCT and received DF (n  =  24) or rhTM (n  =  41) for SOS treatment were collected. The complete response rates for SOS on day 100 were 50% and 54% in the DF and rhTM groups, respectively. The 100-day overall survival rates were 50% in the DF group, and 48% in the rhTM group. Several severe hemorrhagic adverse events were observed in one patient in the DF group and five patients in the rhTM group. The main causes of death were SOS-related death, and no patient died of direct adverse events of DF or rhTM. Our results suggest that rhTM, as well as DF, can be effective as a novel treatment option for SOS.

  May 2019, Bone marrow transplantation, 54(5) (5), 674 - 680, English, International magazine

  [Refereed]

  Scientific journal


• Vitamin D receptor-mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis.

  Kanako Wakahashi, Kentaro Minagawa, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Akiko Sada, Noboru Asada, Mari Sato, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Yoshio Katayama

  Myelofibrosis in myeloproliferative neoplasms (MPNs) with mutations such as JAK2V617F is an unfavorable sign for uncontrollable disease progression in the clinic and is complicated with osteosclerosis whose pathogenesis is largely unknown. Because several studies have revealed that macrophages are an indispensable supporter for bone-forming osteoblasts, we speculated that macrophages might play a significant role in the proliferation of collagen-producing myofibroblasts in marrow fibrotic tissues. Here, we show that myelofibrosis critically depends on macrophages whose differentiation is skewed by vitamin D receptor (VDR) signaling. In our novel myelofibrosis model established by transplantation of VDR+/+ hematopoietic stem/progenitor cells into VDR-/- mice, donor-derived F4/80+ macrophages proliferated together with recipient-derived α-smooth muscle actin-positive myofibroblasts, both of which comprised fibrotic tissues with an indistinguishable spindle-shaped morphology. Interfering VDR signals, such as low vitamin D diet and VDR deficiency in donor cells as well as macrophage depletion prevented myelofibrosis in this model. These interventions also ameliorated myelofibrosis in JAK2V617F-driven murine MPNs likely in a transforming growth factor-β1- or megakaryocyte-independent manner. These results suggest that VDR and macrophages may be novel therapeutic targets for MPNs with myelofibrosis.

  Apr. 2019, Blood, 133(15) (15), 1619 - 1629, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transformed Follicular Lymphoma (TFL) Predicts Outcome in Advanced Endometrial Cancer.

  Senn Wakahashi, Fumi Kawakami, Kanako Wakahashi, Kentaro Minagawa, Keitaro Matsuo, Yoshio Katayama, Hideto Yamada, Toshimitsu Matsui, Tamotsu Sudo

  Background: Transformed follicular lymphoma (TFL, ZC3H12D) was identified as a candidate tumor suppressor gene that contributes to cell-cycle arrest through regulation of Rb phosphorylation, but the clinical impact of TFL is unknown. The goal of this study was to evaluate the prognostic significance of TFL expression in advanced endometrial cancer.Methods: Tissue samples were obtained from 103 patients with Federation Internationale des Gynaecologistes et Obstetristes stage III-IV endometrial cancer. Associations between TFL expression and outcomes were evaluated using the Kaplan-Meier method and multivariate Cox proportional hazards regression models.Results: There were 24 TFL-low cases (23.3%) and the 10-year progression-free survival (PFS) and overall survival (OS) in these cases were lower than those for patients with normal TFL expression in univariate analysis (PFS, P = 0.003; OS, P = 0.106). In multivariate analysis, TFL status was a significant predictor for PFS [HR = 2.76; 95% confidence interval (CI), 1.45-5.28; P = 0.002] and OS (HR = 1.94; 95% CI, 0.91-4.11; P = 0.085), adjusted for covariates. The TFL gene maps to human chromosome 6q25.1, where estrogen receptor alpha (ERα) gene ESR1 is also located. Lack of ERα expression is a poor prognostic factor in early endometrial cancer. Among 41 ERα-low patients, 10-year PFS was significantly lower in 15 TFL-low cases (univariate analysis, P = 0.055; multivariate analysis, HR = 4.70; 95% CI, 1.68-13.20; P = 0.003).Conclusions: We identified TFL as a strong independent prognostic factor, regardless of ERα status.Impact: An investigation of the mechanism underlying tumor suppression by TFL may lead to new therapies for patients with advanced endometrial cancer. Cancer Epidemiol Biomarkers Prev; 27(8); 963-9. ©2018 AACR.

  Aug. 2018, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 27(8) (8), 963 - 969, English, International magazine

  [Refereed]

  Scientific journal


• 慢性好塩基球性白血病から急性骨髄性白血病へと進展した一症例

  太田由理, 菊間知恵, 山下智江, 野口依子, 中町祐司, 北尾章人, KATAYAMA YOSHIO, Matsuoka Hiroshi, 河野誠司, 三枝淳

  (一社)日本検査血液学会, Jun. 2018, 日本検査血液学会雑誌, 19(学術集会) (学術集会), S182 - S182, Japanese

  [Refereed]

  Research society


• 【色素沈着を伴う皮膚病】 <臨床例>トシリズマブによる長期間の治療効果を観察しえた多中心性Castleman病に伴う皮膚形質細胞増多症

  寒川 愛美, NAGAI HIROSHI, KATAYAMA YOSHIO, NISHIGORI CHIKAKO

  Jun. 2018, 皮膚病診療, 40(6) (6), 587 - 590, Japanese

  [Refereed]

  Scientific journal


• Late-onset Erythropoietic Protoporphyria Associated with Myelodysplastic Syndrome Treated with Azacitidine.

  Ai Yoshioka, Susumu Fujiwara, Hiroki Kawano, Hajime Nakano, Shigeru Taketani, Toshimitsu Matsui, Yoshio Katayama, Chikako Nishigori

  Medical Journals/Acta D-V, Feb. 2018, Acta dermato-venereologica, 98(2) (2), 275 - 277, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 骨髄異形成症候群の経過中に遊走性血栓性静脈炎を合併した1例

  横山 大輔, 辻本 昌理子, 錦織 千佳子, 川野 宏樹, 片山 義雄

  日本皮膚科学会-大阪地方会・京滋地方会, Dec. 2017, 皮膚の科学, 16(6) (6), 442 - 443, Japanese


• ペランパネルで対処したNCSE非痙攣性てんかん重積発作の1例

  Maeda Yuji, 西山隆, 山田克己, 岡田直己, 川野宏樹, KATAYAMA YOSHIO, 安藤維洋, 西村与志郎, 西 佑翼, 栗原茉希, 大坪里織

  Dec. 2017, Neurosurgical Emergency, 22(2号) (2号), 128 - 134, Japanese

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Picture in Clinical Hematology(No.103) Cilostazol-induced pure white cell aplasia(図説)

  川野宏樹, 川野裕子, 鈴木知秀, 石井慎一, 若橋香奈子, 定明子, 伊藤智雄, 梶本和義, Hayashi Yoshitake, KATAYAMA YOSHIO

  May 2017, 臨床血液, 58(5) (5), 425, Japanese

  [Refereed]

  Scientific journal


• Use of mycophenolate mofetil and a calcineurin inhibitor in allogeneic hematopoietic stem-cell transplantation from HLA-matched siblings or unrelated volunteer donors: Japanese multicenter phase II trials.

  Takahiko Nakane, Hirohisa Nakamae, Takuhiro Yamaguchi, Saiko Kurosawa, Atsuo Okamura, Michihiro Hidaka, Shigeo Fuji, Akio Kohno, Takeshi Saito, Yasutaka Aoyama, Kazuo Hatanaka, Yoshio Katayama, Kimikazu Yakushijin, Toshimitsu Matsui, Motohiro Yamamori, Akiyoshi Takami, Masayuki Hino, Takahiro Fukuda

  Apr. 2017, International journal of hematology, 105(4) (4), 485 - 496, English, Domestic magazine

  [Refereed]

  Scientific journal


• G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.

  Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama

  Feb. 2017, Blood, 129(5) (5), 587 - 597, English, International magazine

  [Refereed]

  Scientific journal


• 血液透析導入時に第VIII因子補充，抗凝固薬の調整を必要とした血友病A患者の１例

  泉博子, Goto Shunsuke, 藤井秀毅, 吉矢邦彦, 橋村裕也, 片山義雄, 石村武志, 藤澤正人, 西慎一

  (一社)日本透析医学会, 2016, 日本透析医学会誌, 49(12) (12), 847 - 852, Japanese

  [Refereed]

  Scientific journal


• A case of intravascular lymphoma diagnosed in an explanted liver after liver transplantation

  Kaori Kuramitsu, Takumi Fukumoto, Yoshihiko Yano, Hirotaka Hirano, Takuyo Misumi, Yosio Katayama, Hiroki Kawano, Kimikazu Yakushijin, Yoh Zen, Tomoo Itoh, Yonson Ku

  Blackwell Publishing Ltd, Oct. 2015, Transplant International, 28(10) (10), 1245 - 1250, English

  [Refereed]

  Scientific journal


• Osteocytes and Homeostasis of Remote Organs

  Mari Sato, Yoshio Katayama

  Aug. 2015, CURRENT OSTEOPOROSIS REPORTS, 13(4) (4), 193 - 197, English

  [Refereed]

  Scientific journal


• Very late-onset reversible cardiomyopathy in patients with chronic GvHD

  H. Kawano, H. Tanaka, T. Yamashita, K. I. Hirata, S. Ishii, T. Suzuki, K. Wakahashi, Y. Kawano, A. Sada, K. Minagawa, F. Kawakami, T. Itoh, A. Baba, T. Matsui, Y. Katayama

  Jun. 2015, Bone Marrow Transplantation, 50(6) (6), 870 - 872, English

  [Refereed]

  Scientific journal


• HIV-negative, HHV-8-unrelated primary effusion lymphoma-like lymphoma with genotypic infidelity and c-MYC expression

  Takao Kashiwagi, Kentaro Minagawa, Hiroki Kawano, Tamaki Hirata, Sayaka Kashiwagi, Yoshihiro Nakagawa, Satoshi Kusaka, Takuma Suzuki, Tadahiro Inagaki, Minoru Kishi, Noriko Miwa, Sachiko Kimura, Miho Takechi, Makoto Koide, Masahide Iwai, Yoshio Katayama, Toshimitsu Matsui

  Sep. 2014, ANNALS OF HEMATOLOGY, 93(9) (9), 1609 - 1610, English

  [Refereed]

  Scientific journal


• [Thrombopoietin receptor agonists administration for acute exacerbation of chronic idiopathic thrombocytopenic purpura and subsequent anticoagulant therapy for accompanying deep venous thrombosis of the lower limbs].

  Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Kentaro Minagawa, Tomofumi Takaya, Tomoya Yamashita, Ken-Ichi Hirata, Kenji Koriyama, Yuichi Nagamatsu, Toshimitsu Matsui, Yoshio Katayama

  We report two patients (70- and 49-year-old Japanese men) with acute exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and deep venous thrombosis of the lower extremities. Both were successfully managed with thrombopoietin receptor agonist (TPO-RA) administration. Both had ITP refractory to steroid treatment. Their immature platelet fraction (absolute-IPF) counts were increased and paralleled the platelet recoveries after TPO-RA (eltrombopag and romiplostim, respectively) without progression of thrombosis. Although ITP has recently been evaluated as a thrombophilic disorder, reports on acute exacerbation of ITP with newly diagnosed thrombosis are limited, and the pathophysiology and association between ITP and thrombosis remain to be elucidated. Moreover, the influences of TPO-RA on thrombosis are still controversial. To our knowledge, this is the first case report describing patients with exacerbation of ITP who developed thrombosis and were treated with TPO-RA. The outcomes of our cases underscore the importance of monitoring thrombosis and not delaying the initiation of anticoagulation treatment during the use of TPO-RA.

  6, Jun. 2014, [Rinsho ketsueki] The Japanese journal of clinical hematology, 55(6) (6), 697 - 702, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• TPO受容体作動薬を使用し抗凝固療法への移行が可能であった下肢深部静脈血栓症合併慢性ITP急性増悪

  川野宏樹, 鈴木知秀, 石井慎一, 若橋香奈子, 川野裕子, 定明子, 皆川健太郎, Takaya Tomofumi, Yamashita Tomoya, Hirata Ken-ichi, 郡山健治, 永松裕一, MATSUI TOSHIMITSU, KATAYAMA YOSHIO

  Jun. 2014, 臨床血液, 55(6号) (6号), 697 - 702, Japanese

  [Refereed]

  Scientific journal


• Unusual hepatic involvement with significant fibrosis in adult T cell leukemia

  Hiroki Kawano, Kanako Wakahashi, Shigeyuki Ebara, Shinichi Ishii, Tomohide Suzuki, Yuko Kawano, Akiko Sada, Kentaro Minagawa, Toshimitsu Matsui, Fumi Kawakami, Yoshitake Hayashi, Tomoo Itoh, Yoshio Katayama

  May 2014, ANNALS OF HEMATOLOGY, 93(5) (5), 897 - 898, English

  [Refereed]

  Scientific journal


• Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis

  Tomoyuki Uchida, Jiro Kitaura, Fumio Nakahara, Katsuhiro Togami, Daichi Inoue, Akie Maehara, Koutarou Nishimura, Kimihito C. Kawabata, Noriko Doki, Kazuhiko Kakihana, Kosuke Yoshioka, Kumi Izawa, Toshihiko Oki, Akiko Sada, Yuka Harada, Kazuteru Ohashi, Yoshio Katayama, Toshimitsu Matsui, Hironori Harada, Toshio Kitamuraa

  May 2014, EXPERIMENTAL HEMATOLOGY, 42(5) (5), 369 - 379, English

  [Refereed]

  Scientific journal


• Recurrence of abdominal large-vessel vasculitis and development of severe Sweet syndrome after a single cycle of 5-azacytidine in a patient with myelodysplastic syndrome

  Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Kentaro Minagawa, Daisuke Ueno, Takashi Yamasaki, Tomoo Itoh, Hiroshi Yokozaki, Yoshio Katayama

  Apr. 2014, EUROPEAN JOURNAL OF HAEMATOLOGY, 92(4) (4), 362 - 364, English

  [Refereed]

  Scientific journal


• Posttranscriptional Modulation of Cytokine Production in T Cells for the Regulation of Excessive Inflammation by TFL

  Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Shinichiro Nishikawa, Chie Fukui, Yuko Kawano, Noboru Asada, Mari Sato, Akiko Sada, Yoshio Katayama, Toshimitsu Matsui

  Feb. 2014, JOURNAL OF IMMUNOLOGY, 192(4) (4), 1512 - 1524, English

  [Refereed]

  Scientific journal


• Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

  Mari Sato, Noboru Asada, Yuko Kawano, Kanako Wakahashi, Kentaro Minagawa, Hiroki Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Yoshio Katayama

  Nov. 2013, CELL METABOLISM, 18(5) (5), 749 - 758, English

  [Refereed]

  Scientific journal


• Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage

  Hiroki Kawano, Daisuke Yamamoto, Yoshito Uchihashi, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Kentaro Minagawa, Yoshio Katayama, Eiji Kohmura, Masayoshi Souri, Akitada Ichinose

  Sep. 2013, Blood Coagulation and Fibrinolysis, 24(6) (6), 638 - 641, English

  [Refereed]

  Scientific journal


• Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells

  Noboru Asada, Yoshio Katayama, Mari Sato, Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Mitsune Tanimoto

  Jun. 2013, CELL STEM CELL, 12(6) (6), 737 - 747, English

  [Refereed]

  Scientific journal


• 高齢者骨髄腫患者における超低用量レナリドミド療法

  皆川健太郎, 川野宏樹, 鈴木琢真, 稲垣忠弘, 来住稔, 平田珠希, 木村祥子, 武地美保, 小出亮, 岩井正秀, Katayama Yoshio, 松井利充

  Lenalidomide treatment for refractory or relapsed multiple myeloma in elderly patients may be feasible in an outpatient setting. However, difficulties have been associated with the management of adverse effects. Therefore, a dose reduction in lenalidomide has been recommended in some cases. In this report, we encountered the successful treatment of myeloma in 6 elderly patients (aged above 70 years) with very low-dose lenalidomide (5 mg daily). Four patients exhibited more than a partial response with an 8.6 months median follow-up period, which was comparable with previous findings. The major adverse effect observed was infection, which occurred during the first several cycles. Others were less toxic, especially the absence of grade 3/4 toxicities for hematological adverse effects.
  Although a dose reduction in lenalidomide therapy for elderly patients is controversial, a very low dose could be safe and effective. Our group is currently conducting a multi-center prospective trial to evaluate the efficacy of low-dose lenalidomide therapy.

  The Japanese Society of Hematology, 2013, 臨床血液, 54(5) (5), 457 - 462, Japanese

  [Refereed]

  Scientific journal


• Eosinophilia and bone lesion as clinical manifestations of aggressive systemic mastocytosis

  Sakane-Ishikawa E, Kodaka T, Tsunemine H, Itoh K, Akasaka H, Kusama T, Imaizumi K, Taketomi M, Sada A, Katayama Yoshio, Itoh T, Takahashi T

  2013, J Clin Exp Hematop, 53(3) (3), 207 - 13, English

  [Refereed]

  Scientific journal


• A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition

  Hiroki Kawano, Yoshio Katayama, Kentaro Minagawa, Manabu Shimoyama, Mark Henkemeyer, Toshimitsu Matsui

  Jun. 2012, EUROPEAN JOURNAL OF IMMUNOLOGY, 42(6) (6), 1562 - 1572, English

  [Refereed]

  Scientific journal


• [Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis].

  Hiroki Kawano, Kentaro Minagawa, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Toshimitsu Matsui, Yoshio Katayama

  2012, [Rinshō ketsueki] The Japanese journal of clinical hematology, 53(8) (8), 785 - 787, English

  Scientific journal


• 血縁造血幹細胞（骨髄・末梢血）ドナーの声

  Mizobuchi Satoshi, 青 雲, 飯田美奈子, 鈴木律朗, 山下卓也, 福田隆浩, 大橋一輝, 小川啓恭, 鬼塚真仁, 近藤忠一, 金森平和, 黒川峰夫, 宮村耕一, 伊藤俊朗, 衛藤徹也, Katayama Yoshio, 前田哲生, 小寺良尚

  To know the real figure of hematopoietic stem cell donation for further development of donors safety and satisfaction, we analyzed family donors opinions which were collected through nation-wide family donor annual follow up system conducted by Japan Society for Hematopoietic Cell Transplantation (JSHCT) between April , 2006 and March, 2010. The outcomes were then compared between bone marrow (BM) donors and peripheral blood stem cell (PBSC) donors. The ratio of satisfaction (dissatisfaction) after the donation was not different between BM and PBSC donors nevertheless, physical complaints with dissatisfaction were significantly higher among BM donors. Major physical complaint was pain, especially unexpectedly prolonged pain due to marrow aspiration which was assumed to be improved by the development of harvest techniques, of devices such as the size of needles and by further concerns of harvest teams to donors.

  The Japan Society for Hematopoietic Stem Cell Transplantation, 2012, 日本造血細胞移植学会雑誌, 1(1) (1), 6 - 14, Japanese

  [Refereed]

  Scientific journal


• Successful Management of Obstructive Jaundice due to Gallstones with Eculizumab in a Patient with Paroxysmal Nocturnal Hemoglobinuria

  Hiroki Kawano, Kentaro Minagawa, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Toshimitsu Matsui, Hirotaka Hirano, Hideyuki Shiomi, Yonson Ku, Yoshio Katayama

  2012, INTERNAL MEDICINE, 51(18) (18), 2613 - 2616, English

  [Refereed]

  Scientific journal


• Pharmacokinetics-based optimal dose prediction of donor source-dependent response to mycophenolate mofetil in unrelated hematopoietic cell transplantation

  Kanako Wakahashi, Motohiro Yamamori, Kentaro Minagawa, Shinichi Ishii, Shinichirou Nishikawa, Manabu Shimoyama, Hiroki Kawano, Yuko Kawano, Yuriko Kawamori, Akiko Sada, Toshimitsu Matsui, Yoshio Katayama

  Aug. 2011, INTERNATIONAL JOURNAL OF HEMATOLOGY, 94(2) (2), 193 - 202, English

  Scientific journal


• Delayed neutrophil engraftment in cord blood transplantation with intensive administration of mycophenolate mofetil for GVHD prophylaxis

  A. Okamura, M. Shimoyama, S. Ishii, K. Wakahashi, N. Asada, H. Kawano, Y. Kawamori, S. Nishikawa, K. Minagawa, Y. Katayama, T. Matsui

  Jan. 2011, BONE MARROW TRANSPLANTATION, 46(1) (1), 148 - 149, English

  [Refereed]

  Scientific journal


• Unbalanced whole-arm translocation der(18;21)(q10;q10) is a recurrent cytogenetic aberration appearing during progression in myeloid leukemias

  Katsuya Yamamoto, Manabu Shimoyama, Yoshio Katayama, Toshimitsu Matsui

  Dec. 2010, LEUKEMIA RESEARCH, 34(12) (12), E339 - E341, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche

  Yuriko Kawamori, Yoshio Katayama, Noboru Asada, Kentaro Minagawa, Mari Sato, Atsuo Okamura, Manabu Shimoyama, Kimie Nakagawa, Toshio Okano, Mitsune Tanimoto, Shigeaki Kato, Toshimitsu Matsui

  Dec. 2010, BLOOD, 116(25) (25), 5528 - 5535, English

  Scientific journal


• Histiocytic sarcoma with two immunohistopathologically distinct populations

  Kanako Wakahashi, Manabu Shimoyama, Yoshio Katayama, Kentaro Minagawa, Kenji Yoshida, Ryohei Sasaki, Shunji Nakayama, Hiroshi Yokozaki, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Toshimitsu Matsui

  Nov. 2010, INTERNATIONAL JOURNAL OF HEMATOLOGY, 92(4) (4), 642 - 646, English

  [Refereed]

  Scientific journal


• Therapy-related, mixed phenotype acute leukemia with t(1;21)(p36;q22) and RUNX1 rearrangement

  Katsuya Yamamoto, Akiko Sada, Yuko Kawano, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Sep. 2010, CANCER GENETICS AND CYTOGENETICS, 201(2) (2), 122 - 127, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia

  Katsuya Yamamoto, Atsuo Okamura, Kanako Wakahashi, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Jun. 2010, CANCER GENETICS AND CYTOGENETICS, 199(2) (2), 134 - 138, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Possible alternative strategy for stage I imatinib-sensitive testicular seminoma; lessons from a case associated with Philadelphia chromosome-positive acute lymphoblastic leukemia

  A. Okamura, K. Wakahashi, S. Ishii, Y. Katayama, K. Yamamoto, T. Matsui

  May 2010, ANNALS OF ONCOLOGY, 21(5) (5), 1129 - 1130, English

  [Refereed]

  Scientific journal


• Progressive osteosclerosis and visceral calcification after cord blood transplantation

  Noboru Asada, Shinichi Ishii, Kanako Wakahashi, Hiroki Kawano, Yuriko Kawamori, Shinichiro Nishikawa, Kentaro Minagawa, Atsuo Okamura, Manabu Shimoyama, Yoshio Katayama, Yoshitake Hayashi, Tomoo Itoh, Mitsune Tanimoto, Toshimitsu Matsui

  Apr. 2010, INTERNATIONAL JOURNAL OF HEMATOLOGY, 91(3) (3), 542 - 545, English

  [Refereed]

  Scientific journal


• Therapy-related Myelodysplastic/myeloproliferative Neoplasms with del(5q) and t(1;11)(p32;q23) Lacking MLL Rearrangement

  Katsuya Yamamoto, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  2010, INTERNAL MEDICINE, 49(11) (11), 1031 - 1035, English

  Scientific journal


• Two further cases of myelodysplastic syndrome and acute myeloid leukemia with der(5;19)(p10;q10): Association with abnormalities involving chromosomes 12 and 21

  Katsuya Yamamoto, Kanako Wakahashi, Atsuo Okamura, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Jan. 2010, LEUKEMIA RESEARCH, 34(1) (1), E38 - E41, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Extended Mycophenolate Mofetil Administration Beyond Day 30 in Allogeneic Hematopoietic Stem Cell Transplantation as Preemptive Therapy for Severe Graft-Versus-Host Disease

  S. Nishikawa, A. Okamura, M. Yamamori, K. Minagawa, Y. Kawamori, Y. Kawano, H. Kawano, K. Ono, Y. Katayama, M. Shimoyama, T. Matsui

  Nov. 2009, TRANSPLANTATION PROCEEDINGS, 41(9) (9), 3873 - 3876, English

  [Refereed]

  Scientific journal


• Duplication of isodicentric chromosome 21, idic(21)(p11.2), leading to pentasomy 21q in acute myeloid leukemia with multilineage dysplasia

  Manabu Shimoyama, Katsuya Yamamoto, Shinichiro Nishikawa, Kentaro Minagawa, Yoshio Katayama, Toshimitsu Matsui

  Oct. 2009, CANCER GENETICS AND CYTOGENETICS, 194(1) (1), 38 - 43, English

  [Refereed]

  Scientific journal


• Inhibition of G(1) to S Phase Progression by a Novel Zinc Finger Protein P58(TFL) at P-bodies

  Kentaro Minagawa, Yoshio Katayama, Shinichiro Nishikawa, Katsuya Yamamoto, Akiko Sada, Atsuo Okamura, Manabu Shimoyama, Toshimitsu Matsui

  Jun. 2009, MOLECULAR CANCER RESEARCH, 7(6) (6), 880 - 889, English

  [Refereed]

  Scientific journal


• Unbalanced whole-arm translocation der(5;19)(p10;q10) is a novel and recurrent cytogenetic aberration in myelodysplastic syndrome

  Katsuya Yamamoto, Atsuo Okamura, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Mar. 2009, LEUKEMIA RESEARCH, 33(3) (3), 377 - 383, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• [Defibrotide therapy for patients with sinusoidal obstruction syndrome after hematopoietic stem cell transplantation].

  Kimikazu Yakushijin, Atsuo Okamura, Kanako Ono, Yuko Kawano, Hiroki Kawano, Yohei Funakoshi, Yuriko Kawamori, Shinichiro Nishikawa, Kentaro Minagawa, Akiko Sada, Manabu Shimoyama, Katsuya Yamamoto, Yoshio Katayama, Toshimitsu Matsui

  Sinusoidal obstruction syndrome (SOS) is one of the life-threatening complications caused by endothelial damage to the hepatic sinusoids after hematopoietic stem cell transplantation. However, a satisfactory treatment for SOS has not yet been established. Defibrotide has anti-thrombotic, anti-ischemic, anti-inflammatory, and thrombolytic properties without systemic anticoagulant effects. We treated eight post-transplant SOS patients with defibrotide. Three patients responded to the therapy and the initial response was observed within a week. In addition to the improvement of liver function, rapid recovery of response to diuretic drugs followed by the improvement of renal function was observed. All of the five patients with respiratory dysfunction died despite administration of defibrotide, suggesting that early treatment might lead to better outcomes. There were no severe adverse effects directly due to defibrotide administration. Defibrotide seems to be a promising treatment for SOS, and the initiation of a clinical study in Japan would be important.

  Jan. 2009, [Rinsho ketsueki] The Japanese journal of clinical hematology, 50(1) (1), 3 - 8, Japanese, Domestic magazine

  Scientific journal


• 造血幹細胞移植後の類洞閉塞症候群に対するデフィブロタイドの有効性の検討

  Okamura Atsuo, Katayama Yoshio, Matsui Toshimitsu

  Jan. 2009, 臨床血液, 50(1) (1), 3 - 8, Japanese

  [Refereed]

  Scientific journal


• Pure red cell aplasia with primary sclerosing cholangitis

  Yuko Kawano, Yoshio Katayama, Atsuo Okamura, Manabu Shimoyama, Yonson Ku, Toshimitsu Matsui

  Dec. 2008, INTERNATIONAL JOURNAL OF HEMATOLOGY, 88(5) (5), 599 - 601, English

  [Refereed]

  Scientific journal


• Pharmacokinetics-based optimal dose-exploration of mycophenolate mofetil in allogeneic hematopoietic stem cell transplantation

  Atsuo Okamura, Motohiro Yamamori, Manabu Shimoyama, Yuko Kawano, Hiroki Kawano, Yuriko Kawamori, Shinichiro Nishikawa, Kentaro Minagawa, Kimikazu Yakushijin, Yoshio Katayama, Toshiyuki Sakaeda, Midori Hirai, Toshimitsu Matsui

  Jul. 2008, INTERNATIONAL JOURNAL OF HEMATOLOGY, 88(1) (1), 104 - 110, English

  [Refereed]

  Scientific journal


• Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia

  Katsuya Yamamoto, Kimikazu Yakushijin, Shinichiro Nishikawa, Kentaro Minagawa, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  May 2008, CANCER GENETICS AND CYTOGENETICS, 183(1) (1), 77 - 81, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dock2 participates in bone marrow lympho-hematopoiesis

  Tomoko Kikuchi, Shiro Kubonishi, Misako Shibakura, Noriko Namba, Toshimitsu Matsui, Yoshinori Fukui, Mitsune Tanimoto, Yoshio Katayama

  Feb. 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 367(1) (1), 90 - 96, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A multicenter analysis of the FIP1L1-alpha PDGFR fusion gene in Japanese idiopathic hypereosinophilic syndrome: an aberrant splicing skipping the alpha PDGFR exon 12

  Akiko Sada, Yoshio Katayama, Katsuya Yamamoto, Shin Okuyama, Hideshi Nakata, Hirotoshi Shimada, Kazuo Oshimi, Mayumi Mori, Toshimitsu Matsui

  Dec. 2007, ANNALS OF HEMATOLOGY, 86(12) (12), 855 - 863, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Derivative (3)t(3;18)(q27;q21)t(18;16)(q21;?) involving the BCL2 and BCL6 genes in follicular lymphoma with t(3;14;18) (q27; q32; q21)

  Katsuya Yamamoto, Kanako Ono, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Nov. 2007, CANCER GENETICS AND CYTOGENETICS, 179(1) (1), 69 - 75, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Chronic myeloid leukemia with a rare variant BCR-ABL translocation: t(9;22;21)(q34;q11.2;q11.2)

  Mai Takeuchi, Yoshio Katayama, Atsuo Okamura, Katsuya Yamamoto, Manabu Shimoyama, Toshimitsu Matsui

  Nov. 2007, CANCER GENETICS AND CYTOGENETICS, 179(1) (1), 85 - 87, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Deregulation of a possible tumour suppressor gene, ZC3H12D, by translocation of IGK@ in transformed follicular lymphoma with t(2;6)(p12;q25)

  Kentaro Minagawa, Katsuya Yamamoto, Shinichiro Nishikawa, Mitsuhiro Ito, Akiko Sada, Kimikazu Yakushijin, Atsuo Okamura, Manabu Shimoyama, Yoshio Katayama, Toshimitsu Matsui

  Oct. 2007, BRITISH JOURNAL OF HAEMATOLOGY, 139(1) (1), 161 - 163, English

  Scientific journal


• 骨髄限局増殖を来したT細胞性顆粒リンパ球白血病

  KATAYAMA YOSHIO, 岡村篤夫, 西川真一郎, 波戸章郎, 下山学, 山本克也, HAYASHI YOSHITAKE, 松井利充

  Jul. 2007, 臨床血液, 48(7) (7), 576 - 580, Japanese

  [Refereed]

  Scientific journal


• Translocation (7;9)(q22;q34) in therapy-related myelodysplastic syndrome after allogeneic bone marrow transplantation for acute myeloblastic leukemia

  Katsuya Yamamoto, Kimikazu Yakushijin, Yuriko Kawamori, Kentaro Minagawa, Yoshio Katayama, Toshimitsu Matsui

  Jul. 2007, CANCER GENETICS AND CYTOGENETICS, 176(1) (1), 61 - 66, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism

  Katsuya Yamamoto, Atsuo Okamura, Hiroki Kawano, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Jul. 2007, CANCER GENETICS AND CYTOGENETICS, 176(2) (2), 144 - 149, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Successful engraftment in reduced-intensity cord blood transplantation (CBT) as a salvage therapy for graft failure after primary CBT in adults

  Yuriko Kawamori, Kimikazu Yakushijin, Atsuo Okamura, Shinichiro Nishikawa, Kentaro Minagawa, Manabu Shimoyama, Katsuya Yamamoto, Yoshio Katayama, Toshimitsu Matsui

  May 2007, TRANSPLANTATION, 83(9) (9), 1281 - 1282, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rapid hematopoietic progenitor mobilization by sulfated colominic acid

  Shiro Kubonishi, Tomoko Kikuchi, Shinya Yamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Toshimitsu Matsui, Mitsune Taninioto, Yoshio Katayama

  Apr. 2007, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 355(4) (4), 970 - 975, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Predominant infiltration of monocytes in chronic graft-versus-host disease

  Noriko Namba, Katsuii Shinagawa, Nobuharu Fujii, Yoshinobu Maeda, Fumihiko Ishimaru, Kazurna Ikeda, Toshimitsu Matsui, Mitsune Tanimoto, Yoshio Katayama

  Jan. 2007, TRANSPLANTATION, 83(2) (2), 220 - 224, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early kinetics of engraftment following reduced-intensity stem cell transplantation: Fludarabine and cyclophosphamide versus fludarabine and busulfan.

  Teruhiko Kozuka, Fumihiko Ishimaru, Keitaro Matsuo, Hiromi Nakashima, Nobuharu Fujii, Kenichi Matsuoka, Eisei Kondo, Yoshio Katayama, Yoshinobu Maeda, Katsuji Shinagawa, Kazuma Ikeda, Mitsune Tanimoto

  Nov. 2006, BLOOD, 108(11) (11), 838A - 838A, English

  [Refereed]


• Chronic lymphoproliferative disorder with regulatory T-cell phenotype

  Tomoko Kikuchi, Yoshio Katayama, Shiro Kubonishi, Toshiyuki Watanabe, Yukari Watanabe, Ken-ichi Matsuoka, Yoshinobu Maeda, Noriko Namba, Taro Masunari, Ryusuke Nasu, Kazuma Ikeda, Mitsune Tanimoto

  Sep. 2006, AMERICAN JOURNAL OF HEMATOLOGY, 81(9) (9), 713 - 716, English

  Scientific journal


• Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

  Y Katayama, M Battista, WM Kao, A Hidalgo, AJ Peired, SA Thomas, PS Frenette

  Jan. 2006, CELL, 124(2) (2), 407 - 421, English

  Scientific journal


• CD44 is a physiological E-selectin ligand on neutrophils

  Y Katayama, A Hidalgo, JS Chang, A Peired, PS Frenette

  Apr. 2005, JOURNAL OF EXPERIMENTAL MEDICINE, 201(8) (8), 1183 - 1189, English

  [Refereed]

  Scientific journal


• Integrin alpha(4)beta(7) and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation

  Y Katayama, A Hidalgo, A Peired, PS Frenette

  Oct. 2004, BLOOD, 104(7) (7), 2020 - 2026, English

  [Refereed]

  Scientific journal


• The integrin alpha M beta 2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization

  A Hidalgo, AJ Peired, LA Weiss, Y Katayama, PS Frenette

  Aug. 2004, BLOOD, 104(4) (4), 993 - 1001, English

  [Refereed]

  Scientific journal


• PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha 4 integrin

  Y Katayama, A Hidalgo, BC Furie, D Vestweber, B Furie, PS Frenette

  Sep. 2003, BLOOD, 102(6) (6), 2060 - 2067, English

  [Refereed]

  Scientific journal


• Galactocerebrosides are required postnatally for stromal-dependent bone marrow lymphopoiesis

  Y Katayama, PS Frenette

  Jun. 2003, IMMUNITY, 18(6) (6), 789 - 800, English

  [Refereed]

  Scientific journal


• Monitoring of CD59 expression in paroxysmal nocturnal hemoglobinuria treated with danazol

  Y Katayama, Y Hiramatsu, K Kohriyama

  Dec. 2001, AMERICAN JOURNAL OF HEMATOLOGY, 68(4) (4), 280 - 283, English

  [Refereed]

  Scientific journal


• Very late antigen-5 and leukocyte function-associated antigen-1 are critical for early stage hematopoietic progenitor cell homing

  N Asaumi, E Omoto, N Mahmut, Y Katayama, K Takeda, K Shinagawa, M Harada

  Jul. 2001, ANNALS OF HEMATOLOGY, 80(7) (7), 387 - 392, English

  [Refereed]

  Scientific journal


• Chromosome analysis after ex vivo expansion of CD34(+) cells from human cord blood

  Y Katayama, K Miyamoto, K Takenaka, K Imajyo, K Shinagawa, M Harada

  Mar. 2001, CANCER GENETICS AND CYTOGENETICS, 125(2) (2), 161 - 162, English

  [Refereed]

  Scientific journal


• Telomerase activity in peripheral blood mononuclear cells of systemic connective tissue diseases

  Y Katayama, K Kohriyama

  Feb. 2001, JOURNAL OF RHEUMATOLOGY, 28(2) (2), 288 - 291, English

  [Refereed]

  Scientific journal


• Acute thrombocytopenic purpura after ingestion of Sho-saiko-to for hepatitis

  T Kiguchi, F Kimura, K Niiya, Y Katayama, M Harada

  Dec. 2000, LIVER, 20(6) (6), 491 - 491, English

  [Refereed]

  Scientific journal


• Ikaros expression in human hematopoietic lineages

  H Nakayama, F Ishimaru, Y Katayama, K Nakase, N Sezaki, K Takenaka, K Shinagawa, K Ikeda, K Niiya, M Harada

  Nov. 2000, EXPERIMENTAL HEMATOLOGY, 28(11) (11), 1232 - 1238, English

  [Refereed]

  Scientific journal


• Allogeneic peripheral blood stem cell transplantation in 23 adult patients with hematologic malignancies: A single-center experience

  K Takenaka, K Shinagawa, K Sunami, N Fujii, Y Hiramatsu, Y Maeda, Y Nawa, Y Katayama, T Teshima, F Ishimaru, K Kiura, K Ikeda, M Harada

  Oct. 2000, INTERNATIONAL JOURNAL OF HEMATOLOGY, 72(3) (3), 362 - 370, English

  [Refereed]

  Scientific journal


• Deletion 7p in gastric MALT lymphoma

  Y Katayama, K Kirizuka, H Nishizaki, Y Nakamoto, M Yamamoto, K Kohriyama

  Aug. 2000, CANCER GENETICS AND CYTOGENETICS, 121(1) (1), 86 - 89, English

  [Refereed]

  Scientific journal


• Disproportion of helper T cell subsets in peripheral blood of patients with primary Sjogren's syndrome

  K Kohriyama, Y Katayama

  2000, AUTOIMMUNITY, 32(1) (1), 67 - 72, English

  [Refereed]

  Scientific journal


• Sjogren's syndrome complicated with autoimmune hepatitis and antiphospholipid antibody syndrome

  Y Katayama, K Kohriyama, K Kirizuka, H Nishizaki, H Fujii, Y Tanji

  Jan. 2000, INTERNAL MEDICINE, 39(1) (1), 73 - 76, English

  [Refereed]

  Scientific journal


• Granulocyte colony-stimulating factor and lineage-independent modulation of VLA-4 expression on circulating CD34+ cells

  Yano T, KATAYAMA YOSHIO, Sunami K, Ishimaru F, Shinagawa K, Ikeda K, Omoto E, Niiya K, Harada M

  Jan. 2000, Int J Hematol, 71(4) (4), 328 - 33, English

  [Refereed]

  Scientific journal


• In vitro inhibition of hematopoiesis in a patient with systemic sclerosis treated with D-penicillamine

  Y Katayama, K Kohriyama, T Matsui

  Nov. 1999, JOURNAL OF RHEUMATOLOGY, 26(11) (11), 2493 - 2495, English

  [Refereed]

  Scientific journal


• Double high-dose chemotherapy supported by autologous transplantation of peripheral blood stem cells for treatment of an elderly patient with small-cell lung cancer

  H Yamane, A Bessho, K Kiura, M Tabata, Y Katayama, K Motoda, T Tsuchida, N Nogami, A Hiraki, H Ueoka, M Harada

  Nov. 1999, INTERNAL MEDICINE, 38(11) (11), 892 - 895, English

  [Refereed]

  Scientific journal


• Establishment and characterization of a novel ALL-L3 cell line (BALM- 18): Induction of apoptosis by anti-IgM and inhibition of apoptosis by bone marrow stroma cells

  Yoshinobu Matsuo, Akira Sugimoto, Akira Harashima, Chiharu Nishizaki, Fumihiko Ishimaru, Eisei Kondo, Yoshio Katayama, Mine Harada, Kunzo Orita

  Jun. 1999, Leukemia Research, 23(6) (6), 559 - 568, English

  [Refereed]

  Scientific journal


• Hematopoietic progenitor cells from allogeneic bone marrow transplant donors circulate in the very early post-transplant period

  Y Katayama, N Mahmut, H Takimoto, Y Maeda, T Yano, K Kojima, T Azuma, M Hara, K Imajyo, S Takahashi, T Kai, Y Ohno, T Miyamoto, K Nagafuji, K Matsue, K Takenaka, T Teshima, K Shinagawa, F Ishimaru, E Omoto, M Harada

  Apr. 1999, BONE MARROW TRANSPLANTATION, 23(7) (7), 659 - 665, English

  [Refereed]

  Scientific journal


• High-dose ifosfamide, carboplatin and etoposide with autologous peripheral blood progenitor cell transplantation for small-cell lung cancer

  A Bessho, H Ueoka, K Kiura, M Tabata, K Sunami, Y Katayama, H Yamane, A Hiraki, M Harada

  Jan. 1999, ANTICANCER RESEARCH, 19(1B) (1B), 693 - 698, English

  [Refereed]

  Scientific journal


• Analysis of circulating hematopoietic progenitor cells after peripheral blood stem cell transplantation

  N Mahmut, Y Katayama, K Takenaka, T Teshima, Y Ohno, K Imajyo, M Hara, K Shinagawa, F Ishimaru, K Ikeda, K Niiya, M Harada

  Jan. 1999, INTERNATIONAL JOURNAL OF HEMATOLOGY, 69(1) (1), 36 - 42, English

  [Refereed]

  Scientific journal


• Improvement with disodium cromoglycate of neutrophil phagocytosis and respiratory burst activity in a patient with hyperimmunoglobulin E syndrome

  K Kojima, Y Inoue, Y Katayama, M Kataoka, K Sunami, S Fukuda, T Sezaki, E Omoto, M Harada

  Nov. 1998, ALLERGY, 53(11) (11), 1101 - 1103, English

  [Refereed]

  Scientific journal


• Replating potential of colony-forming units of granulocytes/macrophages (CFU-GM) expanded ex vivo by stem cell factor, interleukin (IL)-3, IL-6, granulocyte colony-stimulating factor, erythropoietin with or without thrombopoietin

  Y Katayama, K Takenaka, N Mahmut, T Teshima, K Shinagawa, E Omoto, M Harada

  Aug. 1998, INTERNATIONAL JOURNAL OF HEMATOLOGY, 68(2) (2), 157 - 168, English

  [Refereed]

  Scientific journal


• Myelodysplastic syndrome with translocation (8;21): a distinct myelodysplastic syndrome entity or M2-acute myeloid leukemia with extensive myeloid maturation?

  K Kojima, E Omoto, M Hara, K Sasaki, Y Katayama, Y Nawa, Y Kimura, T Azuma, H Takimoto, M Harada

  Jun. 1998, ANNALS OF HEMATOLOGY, 76(6) (6), 279 - 282, English

  [Refereed]

  Scientific journal


• Bone marrow necrosis in a patient with acute myeloblastic leukemia during administration of G-CSF and rapid hematologic recovery after allotransplantation of peripheral blood stem cells

  Y Katayama, S Deguchi, K Shinagawa, T Teshima, K Notohara, K Taguchi, E Omoto, M Harada

  Mar. 1998, AMERICAN JOURNAL OF HEMATOLOGY, 57(3) (3), 238 - 240, English

  [Refereed]

  Scientific journal


• Trisomy 12 and t(14;18) in B-cell chronic lymphocytic leukemia

  K Kojima, M Taniwaki, T Yoshino, Y Katayama, K Sunami, S Fukuda, E Omoto, M Harada, T Sezaki

  Feb. 1998, INTERNATIONAL JOURNAL OF HEMATOLOGY, 67(2) (2), 199 - 203, English

  [Refereed]

  Scientific journal


• Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)

  Y Matsuo, RAF MacLeod, CC Uphoff, HG Drexler, C Nishizaki, Y Katayama, G Kimura, N Fujii, E Omoto, M Harada, K Orita

  Sep. 1997, LEUKEMIA, 11(9) (9), 1469 - 1477, English

  [Refereed]

  Scientific journal


• G-CSF-induced mobilization of peripheral blood stem cells for allografting: comparative study of daily single versus divided dose of G-CSF

  T Yano, Y Katayama, K Sunami, S Deguchi, Y Nawa, Y Hiramatsu, H Nakayama, T Arakawa, F Ishimaru, T Teshima, K Shinagawa, E Omoto, M Harada

  Aug. 1997, INTERNATIONAL JOURNAL OF HEMATOLOGY, 66(2) (2), 169 - 178, English

  [Refereed]

  Scientific journal


• Clonal evolution to acute myeloblastic leukemia with MLL gene rearrangement from trisomy 8 clone

  Y Katayama, H Takimoto, N Fujii, G Kimura, E Omoto, M Harada

  Aug. 1997, LEUKEMIA, 11(8) (8), 1380 - 1382, English

  [Refereed]

  Scientific journal


• Common clonal origin of lymphocytes and plasma cells in splenic lymphoma with villous lymphocytes

  Y Katayama, K Kojima, T Yoshino, Y Matsuo, M Isokawa, T Yano, H Oka, M Yamaguchi, S Deguchi, J Tsuchiyama, K Hayashi, T Teshima, K Shinagawa, F Ishimaru, E Omoto, M Harada

  Jun. 1997, BRITISH JOURNAL OF HAEMATOLOGY, 97(3) (3), 626 - 634, English

  [Refereed]

  Scientific journal


• The effects of a simplified method for cryopreservation and thawing procedures on peripheral blood stem cells

  Y Katayama, T Yano, A Bessho, S Deguchi, K Sunami, N Mahmut, K Shinagawa, E Omoto, S Makino, T Miyamoto, S Mizuno, T Fukuda, T Eto, T Fujisaki, Y Ohno, S Inaba, Y Niho, M Harada

  Feb. 1997, BONE MARROW TRANSPLANTATION, 19(3) (3), 283 - 287, English

  [Refereed]

  Scientific journal


• Androgen therapy in combination with granulocyte colony-stimulating factor and erythropoietin in a patient with refractory anemia

  Y Katayama, K Kojima, E Omoto, M Harada

  Dec. 1996, INTERNATIONAL JOURNAL OF HEMATOLOGY, 65(1) (1), 89 - 92, English

  [Refereed]

  Scientific journal


• Low-dose melphalan for treatment of high-risk myelodysplastic syndromes

  E Omoto, S Deguchi, S Takaba, K Kojima, T Yano, Y Katayama, K Sunami, M Takeuchi, F Kimura, M Harada, Kimura, I

  Apr. 1996, LEUKEMIA, 10(4) (4), 609 - 614, English

  [Refereed]

  Scientific journal


• Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome)

  K Kojima, E Omoto, Y Katayama, M Uno, Takada, I, G Kimura, A Kanehiro, S Tada, K Hayashi, Kimura, I, H Sanada, M Harada

  Feb. 1996, INTERNATIONAL JOURNAL OF HEMATOLOGY, 63(2) (2), 149 - 154, English

  [Refereed]

  Scientific journal

• Bone: a key aspect to understand phenomena in clinical hematology.

  Kanako Wakahashi, Yoshio Katayama

  The bone marrow (BM) is located inside the bone. Now, it appears that bone tissue functionally communicates with the BM hematopoietic system. Osteoblast lineage cells serve as a part of the microenvironment for immature hematopoietic (stem/progenitor) cells. In contrast, mature hematopoietic cells such as neutrophils and macrophages play a critical role to regulate osteoblast activity. A progressive distortion of this precise inter-organ communication between hematopoietic and skeletal systems may lead to hematologic disorders. Recent studies have revealed that vitamin D receptor is a pivotal bridging molecule for this network and for the pathogenesis of myelofibrosis.

  Last, Mar. 2020, Journal of bone and mineral metabolism, 38(2) (2), 145 - 150, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Vitamin D receptor: A critical regulator of inter-organ communication between skeletal and hematopoietic systems.

  Yoshio Katayama

  The functions of vitamin D receptor (VDR) have been extensively studied, for example, in the bone biology field. It is widely known that VDR knockout mice display the characteristic features of rickets type II. However, the contribution of VDR signaling to bone marrow (BM) hematopoiesis in association with the phenomena observed in clinical hematology has not been evaluated thoroughly. Hematopoietic stem cells (HSCs) can be mobilized from the BM into and harvested from peripheral blood as a BM transplantation source for the curable treatment of hematologic malignancies. This HSC mobilization can be achieved by the administration of cytokine granulocyte colony-stimulating factor (G-CSF) for several consecutive days. We have reported that, using the murine model, G-CSF induces the high sympathetic tone in the BM and a β2-adrenergic signal into osteoblasts induces a rapid and drastic increase of VDR, which is critical for the subsequent cascade for HSC mobilization. This is an example of the transient deviation of the inter-organ communication in three different systems (nervous, skeletal, and hematopoietic) bridged by VDR in osteoblasts. It would be important to reconsider VDR as a pivotal molecule that mediates inter-organ communication to broaden the application of vitamin D signal modulators.

  Jun. 2019, The Journal of steroid biochemistry and molecular biology, 190, 281 - 283, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Wntシグナルによる造血幹細胞運命制御

  Katayama Yoshio

  Mar. 2019, Clinical Calcium, 29(3) (3), 75 - 79, Japanese

  [Invited]

  Introduction commerce magazine


• 「神戸大学的」Clinical Problem-Solving 1ヵ月続く発熱と腹痛で入院した17歳男性

  村前直和, Sakaguchi Kazuhiko, 高木泰尚, 大山友梨, 林佳菜恵, 森寛行, 大西輝, KATAYAMA YOSHIO, 森健太, 全陽

  Dec. 2018, 日本内科学会雑誌, 107(12号) (12号), 2546 - 2554, Japanese

  [Refereed]

  Others


• TFL Deletion Induces Incredible CXCL13 Secretion and Cachexia in Vavp-Bcl2 Transgenic Mice

  Kentaro Minagawa, Kanako Wakahashi, Fukui Chie, Shinichiro Nishikawa, Noboru Asada, Yuko Kawano, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Toshimitsu Matsui

  Nov. 2018, BLOOD, 132, English

  Summary international conference


• 自然免疫細胞によるOsteoimmunology

  KATAYAMA YOSHIO

  Dec. 2017, Clinical Calcium, 27(12) (12), 77 - 84, Japanese

  Introduction commerce magazine


• 骨髄造血微小環境と骨代謝

  KATAYAMA YOSHIO

  Nov. 2017, 炎症と免疫, 25(6) (6), 7 - 14, Japanese

  Introduction commerce magazine


• 腫瘍性好酸球増多

  若橋香奈子, 川野宏樹, KATAYAMA YOSHIO

  Sep. 2017, 臨床免疫・アレルギー科, 68(3) (3), 303 - 309, Japanese

  Introduction commerce magazine


• 交感神経による好中球を介したG-CSFによる動員調整機構

  川野裕子, KATAYAMA YOSHIO

  Sep. 2017, 血液内科, 75(3) (3), 364 - 368, Japanese

  Introduction commerce magazine


• 好酸球増多の病態と鑑別診断

  川野宏樹, KATAYAMA YOSHIO

  Aug. 2017, 血液内科, 75(2) (2), 151 - 156, Japanese

  Introduction commerce magazine


• FIP1L1-PDGFRα融合遺伝子検査の新規保険適用

  川野宏樹, KATAYAMA YOSHIO

  Aug. 2017, Medical Technology, 45(8) (8), 787 - 788, Japanese

  Introduction commerce magazine


• 特集 幹細胞システム（特集ゲスト編集） 巻頭言～幹細胞システム～生体の横糸と縦糸

  KATAYAMA YOSHIO

  Jun. 2017, Clinical Calcium, 27(6) (6), 7, Japanese

  Introduction commerce magazine


• 高齢発症の骨髄性プロトポルフィリン症の1例

  吉岡愛育, Fujiwara Susumu, 川野宏樹, KATAYAMA YOSHIO, 中野創, 竹谷茂, MATSUI TOSHIMITSU, NISHIGORI CHIKAKO

  Apr. 2017, 日本臨床皮膚科医会雑誌, 34(2号) (2号), 294, Japanese

  Meeting report


• 骨細胞とオステオネットワーク

  Katayama Yoshio

  Jul. 2016, Clinical Calcium, 26(8) (8), 9 - 16, Japanese

  [Invited]

  Introduction commerce magazine


• 骨芽細胞系列とリンパ球造血

  Katayama Yoshio

  Apr. 2016, Clinical Calcium, 26(5) (5), 55 - 60, Japanese

  [Invited]

  Introduction commerce magazine


• 骨細胞による造血・免疫・エネルギー代謝制御

  Katayama Yoshio

  Feb. 2016, 分子リウマチ治療, 9(1) (1), 31 - 35, Japanese

  [Invited]

  Introduction commerce magazine


• G-CSF投与時の副反応のメカニズム-交感神経支配下の好中球によるPGE2産生

  川野裕子, 福井智恵, 若橋香奈子, 石井慎一, 鈴木知秀, 佐藤真理, 佐藤真理, 浅田騰, 川野宏樹, 皆川健太郎, 定明子, 植松智, 植松智, 審良静男, 審良静男, 上出利光, 成宮周, 松井利充, 片山義雄

  2016, 日本造血細胞移植学会総会プログラム・抄録集, 38th


• 骨細胞による造血・免疫・エネルギー代謝制御

  Katayama Yoshio

  金原出版, Nov. 2015, 整形・災害外科, 58(12) (12), 1605 - 1610, Japanese

  [Invited]

  Introduction commerce magazine


• Inter-organ Communication Regulated by Osteocytes : Hematopoietic Stem Cells, Lymphopoiesis and Energy Metabolism

  片山 義雄

  最新医学社, Oct. 2015, 最新医学, 70(10) (10), 2035 - 2042, Japanese


• 骨細胞による多臓器制御 ー造血幹細胞・免疫システムからエネルギー代謝までー

  Katayama Yoshio

  Oct. 2015, 最新医学, 70(10) (10), 143 - 150, Japanese

  [Invited]

  Introduction commerce magazine


• 骨細胞による全身代謝調節機構

  Katayama Yoshio

  Sep. 2015, 細胞, 47(10) (10), 484 - 487, Japanese

  [Invited]

  Introduction commerce magazine


• 好酸球増多症候群（HES）の新分類と腫瘍性HESの分子標的治療

  定明子, Katayama Yoshio, 松井利充

  Aug. 2015, 診断と治療, 103(5) (5), 655 - 660, Japanese

  [Invited]

  Introduction commerce magazine


• 好酸球増多症候群と腫瘍性疾患

  定明子, Katayama Yoshio, 松井利充

  Aug. 2015, アレルギーの臨床, 35(474) (474), 17 - 21, Japanese

  [Invited]

  Introduction commerce magazine


• Osteocytes and Homeostasis of Remote Organs : Bone-Buried Osteocytes Talk to Remote Organs.

  Mari Sato, Yoshio Katayama

  Current Medicine Group LLC 1, Aug. 2015, Current osteoporosis reports, 13(4) (4), 193 - 7, English, International magazine

  [Refereed]


• 好酸球浸潤と血液疾患

  定明子, Katayama Yoshio, 松井利充

  Jul. 2015, 成人病と生活習慣病, 45(7) (7), 871 - 878, Japanese

  [Invited]

  Introduction commerce magazine


• Regulation of hematopoiesis by osteocytes : "seed and soil" based on inter-organ communication

  片山 義雄

  ニューサイエンス社, May 2015, 細胞, 47(5) (5), 254 - 257, Japanese


• 特集 骨髄学～造血ニッチ研究から見えてきた形態学から分子基盤まで～ 序 ～血球学から骨髄学へ～

  Katayama Yoshio

  Mar. 2015, 血液フロンティア, 25(3) (3), 17 - 19, Japanese

  [Invited]

  Introduction commerce magazine


• Communication of bone cells with hematopoiesis, immunity and energy metabolism.

  Noboru Asada, Mari Sato, Yoshio Katayama

  The bone contains the bone marrow. The functional communication between bone cells and hematopoiesis has been extensively studied in the past decade or so. Osteolineage cells and their modulators, such as the sympathetic nervous system, macrophages and osteoclasts, form a complex unit to maintain the homeostasis of hematopoiesis, called the 'microenvironment'. Recently, bone-embedded osteocytes, the sensors of gravity and mechanical stress, have joined the microenvironment, and they are demonstrated to contribute to whole body homeostasis through the control of immunity and energy metabolism. The inter-organ communication orchestrated by the bone is summarized in this article.

  2015, BoneKEy reports, 4, 748 - 748, English, International magazine

  [Refereed]


• Neutrophils Modulate Osteoblastic Niche for Hematopoietic Progenitors Via Prostaglandin E2 Production Triggered By Sympathetic Nervous System

  Yuko Kawano, Chie Fukui, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama

  Dec. 2014, BLOOD, 124(21) (21), English

  Summary international conference


• 骨細胞による造血制御

  浅田騰, Katayama Yoshio

  Sep. 2014, 炎症と免疫, 22(5) (5), 16 - 21, Japanese

  [Invited]

  Introduction commerce magazine


• 骨髄造血と骨・血管連関

  Katayama Yoshio

  Jul. 2014, CLINICAL CALCIUM, 24(7) (7), 69 - 76, Japanese

  [Invited]

  Introduction commerce magazine


• Regulation of hematopoiesis in endosteal microenvironments

  Noboru Asada, Yoshio Katayama

  Jun. 2014, INTERNATIONAL JOURNAL OF HEMATOLOGY, 99(6) (6), 679 - 684, English

  Introduction scientific journal


• Guest editorial: hematopoietic regulators in the marrow: new players in inter-organ communication

  Yoshio Katayama

  Jun. 2014, INTERNATIONAL JOURNAL OF HEMATOLOGY, 99(6) (6), 677 - 678, English

  Others


• 造血環境と骨代謝

  Katayama Yoshio

  May 2014, 実験医学 増刊 骨代謝 つくり、壊し、変えるーそのメカニズムと最新治療, 32(7) (7), 64 - 69, Japanese

  [Invited]

  Introduction commerce magazine


• 骨代謝による造血環境制御

  Katayama Yoshio

  Apr. 2014, CLINICAL CALCIUM, 24(4) (4), 85 - 92, Japanese

  [Invited]

  Introduction commerce magazine


• 同種臍帯血移植におけるCMV再活性化に対しHLA不一致が及ぼす影響

  横山寿行, 加藤俊一, 近藤英生, 前田嘉信, 佐治博夫, 西田徹也, 諫田淳也, 内田直之, 藤原実名美, 宮村耕一, 片山義雄, 高橋聡, 長村登紀子, 加藤剛二, 熱田由子, 神田善伸

  14 Feb. 2014, 日本造血細胞移植学会総会プログラム・抄録集, 36th, 226, Japanese


• HLA一致血縁または7‐8/8HLA一致非血縁ドナーからの同種造血細胞移植におけるMMFおよびカルシニューリン阻害剤を用いたGVHD予防の有用性:多施設共同第2相臨床試験

  中根孝彦, 中前博久, 黒澤彩子, 岡村篤夫, 日高道弘, 山下卓也, 河野彰夫, 齋藤健, 青山泰孝, 畑中一生, 片山義雄, 薬師神公和, 松井利充, 高見昭良, 山口拓洋, 日野雅之, 福田隆浩

  14 Feb. 2014, 日本造血細胞移植学会総会プログラム・抄録集, 36th, 238, Japanese


• 骨と血液 ー造血幹細胞と骨芽細胞ニッチについてー

  川野裕子, Katayama Yoshio

  2014, 腎と骨代謝, 27(2) (2), 157 - 163, Japanese

  [Invited]

  Introduction commerce magazine


• TFL, a hidden post-transcriptional modulator behind inflammation

  Minagawa K, Katayama Yoshio, Matsui T

  2014, Inflammation and Cell Signaling, e244, English

  Introduction scientific journal


• Selective E-selectin ligands

  Yoshio Katayama

  Dec. 2013, BLOOD, 122(24) (24), 3858 - 3860, English

  [Refereed]

  Others


• alpha SMA plus Macrophages Skewed Fro Hematopoietic Stem Cells By Vitamin D3 Initiate Myelofibrosis and Subsequent Osteosclerosis

  Kanako Wakahashi, Kentaro Minagawa, Noboru Asada, Yuko Kawano, Mari Sato, Hiroki Kawano, Akiko Sada, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Yoshio Katayama

  Nov. 2013, BLOOD, 122(21) (21), English

  Summary international conference


• Prostaglandin E2 Regulates Osteoblastic Niche Selectively for Hematopoietic Progenitors through Induction of Osteopontin via EP4 Receptor

  Yuko Kawano, Mari Sato, Noboru Asada, Chie Fukui, Kanako Wakahashi, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama

  Feb. 2013, JOURNAL OF BONE AND MINERAL RESEARCH, 28, English

  Summary international conference


• 骨細胞による多臓器制御

  佐藤真理, KATAYAMA YOSHIO

  2013, THE BONE, 27, 71 - 75, Japanese

  [Invited]

  Introduction commerce magazine


• G-CSFによる造血幹細胞動員のメカニズム

  Katayama Yoshio

  2013, G-CSF（顆粒球コロニー刺激因子）の基礎と臨床（東條有伸 編）, 42 - 52, Japanese

  [Invited]

  Introduction commerce magazine


• 造血幹細胞ニッチ

  Katayama Yoshio

  Oct. 2012, 臨床血液, 53(10) (10), 1819 - 1825, Japanese

  [Invited]

  Introduction scientific journal


• 骨芽細胞ニッチと造血幹細胞のコントロール

  Katayama Yoshio

  Sep. 2012, 医学のあゆみ, 242(9) (9), 712 - 716, Japanese

  [Invited]

  Introduction scientific journal


• CD5, CD7 の両方またはいずれかの発現低下が診断の契機となった単クローン性Tリンパ球増加症

  川野宏樹, 皆川健太郎, 若橋香奈子, 川野裕子, 定 明子, Matsui Toshimitsu, Katayama Yoshio

  「臨床血液」編集部, Aug. 2012, 臨床血液, 53(8) (8), 785 - 787, Japanese

  [Refereed]

  Report scientific journal


• Mycophenolate mofetil: fully utilizing its benefits for GvHD prophylaxis

  Kentaro Minagawa, Motohiro Yamamori, Yoshio Katayama, Toshimitsu Matsui

  Jul. 2012, INTERNATIONAL JOURNAL OF HEMATOLOGY, 96(1) (1), 10 - 25, English

  [Refereed]

  Book review


• 造血幹細胞 造血幹細胞動員の分子メカニズム

  Katayama Yoshio

  Jan. 2012, Annual Review 血液, 2012, 9 - 15, Japanese

  Introduction scientific journal


• Osteocytes Embedded Inside Bone Are Essential for G-CSF-Induced Hematopoietic Stem/Progenitor Mobilization

  Noboru Asada, Yoshio Katayama, Mari Sato, Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Mitsune Tanimoto

  Nov. 2011, BLOOD, 118(21) (21), 327 - 328, English

  Summary international conference


• 造血幹細胞動員の基礎と臨床：最近の話題

  淺田騰, Katayama Yoshio

  Sep. 2011, 血液内科, 63(3) (3), 326 - 331, Japanese

  Introduction scientific journal


• MDSに対するレナリドマイド治療の分子作用機序

  Katayama Yoshio

  Jul. 2011, 臨床血液, 52(7) (7), 447 - 451, Japanese

  Introduction scientific journal


• Pharmacokinetics-based optimal dose prediction of mycophenolate mofetil in unrelated haematopoietic cell transplantation: proposal of strategies depending on donor source

  K. Wakahashi, M. Yamamori, K. Minagawa, H. Kawano, Y. Kawano, A. Sada, Y. Katayama, T. Matsui

  Apr. 2011, BONE MARROW TRANSPLANTATION, 46, S97 - S98, English

  Summary international conference


• 5q-症候群に関する最近の話題

  Katayama Yoshio

  科学評論社, Apr. 2011, 血液内科, 62(4) (4), 513 - 517, Japanese

  Introduction scientific journal


• 造血幹細胞制御における3B(Brain-Bone-Blood)ネットワーク

  川森有里子, Katayama Yoshio

  Mar. 2011, 血液フロンティア, 21(3) (3), 96 - 99, Japanese

  Introduction scientific journal


• 造血幹細胞ニッチの神経調節におけるビタミンＤ受容体の意義

  川森有里子, Katayama Yoshio

  科学評論社, Mar. 2011, 血液内科, 62(3) (3), 376 - 381, Japanese

  Introduction scientific journal


• A NEW ALTERNATIVE STRATEGY FOR STAGE I IMATINIB-SENSITIVE TESTICULAR SEMINOMA; LESSONS FROM A CASE WITH PH plus ALL

  Atsuo Okamura, Kanako Wakahashi, Shinichi Ishii, Hiroki Kawano, Yuriko Kawamori, Noboru Asada, Shinichiro Nishikawa, Kentaro Minagawa, Manabu Shimoyama, Yoshio Katayama, Katsuya Yamamoto, Toshimitsu Matsui

  Nov. 2010, ANNALS OF ONCOLOGY, 21, 37 - 38, English

  Summary international conference


• A Novel Feedback Mechanism by Ephrin-B1/B2 In T Cell Activation: Concentration-Dependent Switch From Costimulation to Inhibition

  Hiroki Kawano, Yoshio Katayama, Kentaro Minagawa, Manabu Shimoyama, Mark Henkemeyer, Toshimitsu Matsui

  Nov. 2010, BLOOD, 116(21) (21), 126 - 126, English

  Summary international conference


• 急性GVHD予防薬ミコフェノール酸モフェチル(MMF)至適投与法の確立に関する研究(第4報)

  岡村篤夫, 若橋香奈子, 川野宏樹, 川野裕子, 川森有里子, 淺田騰, 竹腰久容, 中田登紀江, 西川真一郎, 皆川健太郎, 定明子, 山本克也, 下山学, 片山義雄, 松井利充

  2010, 日本造血細胞移植学会総会プログラム・抄録集, 32nd, 230, Japanese


• フィラデルフイア染色体陽性急性リンパ性白血病合併例から学ぶ,限局期精巣セミノーマに対するイマチニブを用いた新たな治療戦略

  岡村篤夫, 若橋香奈子, 石井慎一, 川野宏樹, 川森有里子, 淺田騰, 西川真一郎, 皆川健太郎, 下山学, 片山義雄, 山本克也, 松井利充

  2010, 日本臨床腫瘍学会学術集会プログラム・抄録集, 8th, 273, Japanese


• 【骨免疫制御のメカニズム 免疫応答の理解から関節リウマチをはじめとした骨関連疾患の治療まで】 造血幹細胞ニッチと骨代謝

  Katayama Yoshio

  Apr. 2009, 実験医学, 27(6) (6), 871 - 875, Japanese

  Introduction scientific journal


• The Promising Strategy of Mycophenolate Mofetil Dosing to Prevent Moderate- to Severe-Acute Graft-Versus-Host Disease.

  Shmichiro Nishikawa, Atsuo Okamura, Motohiro Yamamori, Yoshio Katayama, Manabu Shimoyama, Toshimitsu Matsui

  Nov. 2008, BLOOD, 112(11) (11), 769 - 770, English

  Summary international conference


• 原発性硬化胆肝炎(PSC)経過中に発症し,生体肝移植後に貧血の改善を示した赤芽球癆(PRCA)の一例

  川野裕子, 小野香奈子, 船越洋平, 川野宏樹, 川森有里子, 西川真一郎, 皆川健太郎, 薬師神公和, 岡村篤夫, 下山学, 定明子, 山本克也, 片山義雄, 松井利充, 伊藤光宏, 尾形哲, 具英成

  2008, 臨床血液, 49(9) (9)


• 接着分子と造血幹細胞の生着と動員 （マクロファージフォーラム Mini-review）

  Katayama Yoshio

  2008, 今日の移植, 21(1) (1), 59 - 65, Japanese

  Introduction scientific journal


• （特集：造血幹細胞とその異常） 造血幹細胞動員のメカニズム

  久保西四郎, KATAYAMA YOSHIO

  科学評論社, Jun. 2007, 血液・腫瘍科, 54(6) (6), 655 - 661, Japanese

  Introduction scientific journal


• 類洞閉塞症候群(SOS)発症予測因子としての血小板凝集能検査の有用性

  藥師神公和, 岡村篤夫, 川野裕子, 川野宏樹, 船越洋平, 川森有里子, 西川真一郎, 皆川健太郎, 定明子, 山本克也, 下山学, 片山義雄, 松井利充

  2007, 臨床血液, 48(9) (9)


• 造血幹細胞ニッチの神経系による調節（特集 幹細胞新世紀：ES細胞・体性幹細胞の新たなポテンシャル）

  Katayama Yoshio

  秀潤社, 2007, 細胞工学, 26(5) (5), 493 - 496, Japanese

  Introduction scientific journal


• (用語解説）CD44

  Katayama Yoshio

  2007, 分子細胞治療, 6(4) (4), 90 - 91, Japanese

  Introduction scientific journal


• 造血系細胞のニッチからの遊離における交感神経系の役割

  KATAYAMA YOSHIO

  Jan. 2007, Annual Review 2007 血液, 2007, 38 - 45, Japanese

  Introduction scientific journal


• 再発・治療抵抗性非ホジキンリンパ腫に対するIDEA療法の有効性と安全性の検討

  西森 久和, 藤井 伸治, 松尾 恵太郎, 小林 孝一郎, 杉山 暖子, 田淵 貴大, 山筋 好子, 久保西 四郎, 難波 寛子, 松岡 賢市, 片山 義雄, 前田 嘉信, 品川 克至, 石丸 文彦, 池田 和真, 谷本 光音

  (一社)日本血液学会-東京事務局, Sep. 2006, 臨床血液, 47(9) (9), 1134 - 1134, Japanese


• 交感神経系シグナルによる骨髄から末梢血への造血幹細胞動員の制御

  KATAYAMA YOSHIO

  Aug. 2006, 分子細胞治療, 5(4) (4), 76 - 77, Japanese

  Introduction scientific journal


• 交感神経系シグナルによる骨髄ニッチからの造血幹細胞遊走の制御

  KATAYAMA YOSHIO, Frenette PS

  May 2006, 実験医学, 24(7) (7), 952 - 955, Japanese

  Introduction scientific journal


• 幹細胞増幅と造血因子

  KATAYAMA YOSHIO, 原田実根

  1994, 先端医療, 5, 49 - 52, Japanese

  Introduction scientific journal

• 未来型血液治療学

  松井利充、片山義雄

  Contributor, 好酸球増多症候群•慢性好酸球性白血病, 中外医学社, Oct. 2019, 124-133, Japanese, ISBN: 9784498225183

  Scholarly book


• 内科学 第11版 / 表面マーカー

  Katayama Yoshio

  Others, 朝倉書店, Mar. 2017, Japanese

  Scholarly book


• 血液科 研修ノート / 第2章 血液の機能と仕組み 1. 造血システム

  川野宏樹, Katayama Yoshio

  Others, 診断と治療社, May 2016, Japanese

  Textbook


• 骨・臓器ネットワークとオステオサイト / 骨細胞による遠隔臓器の制御

  Katayama Yoshio

  Others, メディカルレビュー社, Feb. 2016, Japanese

  Scholarly book


• Annual Review 2015 血液 / 骨細胞による造血細胞制御：多臓器間ネットワークに支えられる造血システム

  Katayama Yoshio

  Others, 中外医学社, Jan. 2015, Japanese

  Scholarly book


• G-CSF（顆粒球コロニー刺激因子）の基礎と臨床 / G-CSFによる造血幹細胞動員のメカニズム

  Katayama Yoshio

  Others, 医薬ジャーナル社, Jul. 2013, Japanese

  Scholarly book


• Annual Review 2012 血液 / 造血幹細胞動員の分子メカニズム

  Katayama Yoshio

  Others, 中外医学社, Jan. 2012, Japanese

  Scholarly book


• Annual Review 2007 血液 / 造血系細胞のニッチからの遊離における交感神経の役割

  Katayama Yoshio

  Others, 中外医学社, Jan. 2007, Japanese

  Scholarly book


• 末梢血幹細胞移植の実際 [5. 末梢血幹細胞の凍結保存]

  KATAYAMA YOSHIO

  Others, 南江堂, May 2001, Japanese

  Scholarly book

• Critical regulation of mobilization efficiency by fat via marrow PPARδ(delta)

  Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Toshimitsu Matsui, Yoshio Katayama

  第81回日本血液学会学術集会, Oct. 2019, English

  Oral presentation


• Erythroblasts facilitate progenitor mobilization via FGF23 production under neuronal control

  Shinichi Ishii, Kanako Wakahashi, Tomohide Suzuki, Yuko Kawano, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Seiya Mizuno, Satoru Takahashi, Toshimitsu Matsui, Yoshio Katayama

  第80回 日本血液学会学術集会, Oct. 2018, Japanese, 大阪, Domestic conference

  Oral presentation


• 慢性好塩基球性白血病から急性骨髄性白血病へと進展した一症例

  太田 由理, 菊間 知恵, 山下 智江, 野口 依子, 中町 祐司, 北尾 章人, KATAYAMA YOSHIO, MATSUOKA HIROSHI, KAWANO SEIJI, SAEGUSA JUN

  第19回日本検査血液学会学術集会, Jul. 2018, Japanese, 大宮, Domestic conference

  Oral presentation


• 神経・炎症・造血のクロストーク

  KATAYAMA YOSHIO

  第36回 日本骨代謝学会学術集会, Jul. 2018, Japanese, 長崎, Domestic conference

  [Invited]

  Nominated symposium


• Vitamin D receptor: a bridging molecule for inter-organ commumication between skeletal and hematopoietic systems

  KATAYAMA YOSHIO

  4th Congress on Steroid Research 2018, Jul. 2018, English, ソウル, International conference

  [Invited]

  Nominated symposium


• 骨・骨髄機能連関のひずみとしての造血器疾患

  Katayama Yoshio

  第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 一般社団法人 日本サイトメトリー学会, 神戸, Domestic conference

  [Invited]

  Nominated symposium


• A new evaluation index for left-right unequal ventriculomegaly in very low birth weight infants: Association with walking disabilities at 1.6 years of corrected age

  Ikuta T, Mizobuchi M, Katayama Yoshio, Yoshimoto S, Ioroi T, Yamane M, Morisawa T, Takatera A, Ueda M, Shibata A, Fujita Kaori, Nishimura Noriyuki, Iijima Kazumoto, Morioka Ichiro

  The 2nd Congress of joint European Neonatal Society, May 2017, English, MCA Scientific Events, Venice, Italy, International conference

  Poster presentation


• Defibrotide and Thrombomodulin Treatment for Late Onset Sinusoidal Obstruction Syndrome after allo-HSCT

  Yakushijin Kimikazu, 池添 隆之, 大和田 千桂子, 工藤 寿子, 岡村 浩史, 後藤 裕明, 矢部 普正, 安本 篤史, 桑原 英幸, 藤井 志朗, 賀川 久美子, 池邉 太一, 大西 康, 河野 彰夫, Katayama Yoshio, 吾郷 浩厚, 加藤 光次, 岡村 篤夫, 菊田 敦, 福田 隆浩

  The 39th Annual Meeting of the Japan Socitey for Hematopoietic Cell Transplantation, Mar. 2017, Japanese, The Japan Society for Hematopoietic Cell Transplantation, 島根, Domestic conference

  Oral presentation


• Early Initiation of Defibrotide or Thrombomodulin Treatment for Sinusoidal Obstruction Syndrome

  Yakushijin Kimikazu, 池添 隆之, 大和田 千桂子, 工藤 寿子, 岡村 浩史, 後藤 裕明, 矢部 普正, 安本 篤史, 桑原 英幸, 藤井 志朗, 賀川 久美子, 池邉 太一, 大西 康, 森下 剛久, Katayama Yoshio, 吾郷 浩厚, 加藤 光次, 岡村 篤夫, 菊田 敦, 福田 隆浩

  The 78th Annual Meeting of the Japanese Society of Hematology, Oct. 2016, Japanese, The Japanese Society of Hematology, 横浜, Domestic conference

  Oral presentation


• 広範な皮下血腫と高度の貧血を呈した真性多血症と第XIII/13因子(F13)欠乏症の合併症例

  嬉野 博志, 木塚 遥菜, 佐野 晴彦, 西岡 敦二郎, 後藤 岳郎, 久保田 寧, 安藤 寿彦, 尾崎 司, 惣宇利 正善, Katayama Yoshio, 小島 研介, 一瀬 白帝, 木村 晋也

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本血液学会, 横浜, Domestic conference

  Poster presentation


• トシリズマブによる長期間の治療効果を観察し得た多中心性キャッスルマン病に伴う皮膚形質細胞症の1例

  寒川 愛美, Nagai Hiroshi, Nishigori Chikako, Katayama Yoshio

  第67回日本皮膚科学会中部支部学術大会, Oct. 2016, Japanese, 日本皮膚科学会中部支部, 大阪, Domestic conference

  Oral presentation


• G-CSF primes bone marrow neutrophils to produce prostaglandin E2 via sympathetic nervous system

  Yuko Kawano, Chie Fukui, Shinohara Masakazu, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shu Narumiya, Toshimitsu Matsui, Katayama Yoshio

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本血液学会, 横浜, Domestic conference

  Oral presentation


• Early initiation of defibrotide or thrombomodulin treatment for sinusoidal obstruction syndrome

  Yakushijin Kimikazu, Takayuki Ikezoe, Chikako Ohwada, Kazuko Kudo, Hiroshi Okamura, Hiroaki Goto, Hiromasa Yabe, Atsushi Yasumoto, Hideyuki Kuwabara, Shiro Fujii, Kumiko Kagawa, Taichi Ikebe, Yasyshi Onishi, Yoshihisa Morishita, Katayama Yoshio, Hiroatsu Ago, Koji Kato, Atsuo Okamura, Atsushi Kikuta, Takahiro Fukuda

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本血液学会, 横浜, Domestic conference

  Oral presentation


• Characteristic symptoms of systemic auto-inflammatory disease (SAID) in a patient with MDS

  Kosuke Tokuda, Keisuke Kataoka, Takao Kashiwagi, Toshimitsu Matsui, Sachiko Kimura, Makoto Koide, Masahide Iwai, Hioroki Kawano, Kanako Wakahashi, Katayama Yoshio, Seishi Ogawa

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本血液学会, 横浜, Domestic conference

  Poster presentation


• A prospective study of very low-dose lenalidomide (miniRd) in elderly relapsed/refractory myeloma

  Takao Kashiwagi, Sachiko Kimura, Kentaro Minagawa, Hiroki Kawano, Minoru Kishi, Makoto Koide, Masahide Iwai, Yoko Adachi, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Katayama Yoshio, Toshimitsu Matsui

  第78回日本血液学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本血液学会, 横浜, Domestic conference

  Oral presentation


• 骨髄異形性症候群に合併した高齢発症骨髄性プロトポルフィルン症の1例

  吉岡 愛育, Fujiwara Susumu, 川野 宏樹, 中野 創, 竹谷 茂, Katayama Yoshio, Nishigori Chikako

  第38回日本光医学・光生物学会, Jul. 2016, Japanese, 日本光医学・光生物学会, 京都, Domestic conference

  Oral presentation


• Nationwide Survey of Defbrotide and Recombinant Human Soluble Thrombomodulin for Treatment of Sinusoidal Obstruction Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation

  Yakushijin Kimikazu, Takayuki Ikezoe, Chikako Ohwada, Kazuko Kudo, Hiroshi Okamura, Hiroaki Goto, Hiromasa Yabe, Atsushi Yasumoto, Hideyuki Kuwabara, Shiro Fujii, Kumiko Kagawa, Taichi Ikebe, Yasushi Onishi, Yoshihisa Morishita, Koichi Watamoto, Nobuhiko Uoshima, Daisuke Nakamura, Shuichi Ota, Yasunori Ueda, Tatsuo Oyake, Kazutoshi Koike, Ishikazu Mizuno, Hiroatsu Iida, Katayama Yoshio, Ago Hiroatsu, Koji Kato, Atsuo Okamura, Atsushi Kikuta, Takahiro Fukuda

  42nd, Annual Meeting of the European Society for Blood and Marrow Transplantation, Apr. 2016, English, European Society for Blood and Marrow Transplantation, Valencia, Spain, International conference

  Oral presentation


• Incidence of kernicterus in Japanese preterm infants <30 wks gestation born in 2011

  Morioka Ichiro, Nakamura H, Okada H, Katayama Yoshio, Kunikata T, Kondo M, Nakamura Makoto, Hosono S, Yasuda S, Yokoyama N, Wada H, Yonetani M

  Pediatric Academic Societies (PAS) Annual Meeting 2016, Apr. 2016, English, Pediatric Academic Societies, Baltimore, USA, International conference

  Poster presentation


• The mechanism of fever and bone pain by G-CSF administration-production of PGE2 from neutrophils governed by synpathetic neuvous system

  川野裕子, 福井知恵, 若橋香奈子, 石井慎一, 鈴木知秀, 佐藤真理, 淺田騰, 川野宏樹, 皆川健太郎, 定明子, 植松智, 審良静男, 上出利光, 成宮周, 松井利充, Katayama Yoshio

  第38回日本造血細胞移植学会総会, Mar. 2016, Japanese, 日本造血細胞移植学会, 名古屋, Domestic conference

  Oral presentation


• αSMA+ macrophages skewed from HSCs by vitamin D3 initiate myelofibrosis with osteosclerosis

  Kanako Wakahashi, Kentaro Minagawa, Noboru Asada, Yuko Kawano, Mari Sato, Hiroki Kawano, Akiko Sada, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Katayama Yoshio

  第77回日本血液学会, Oct. 2015, English, 日本血液学会, 金沢, Domestic conference

  Oral presentation


• A successful treatment with low-dose rituximab for AIHA severe steroid-psychosis

  Miki Matsui, Takao Kashiwagi, Sayaka Kashiwagi, Minoru Kishi, Sachiko Kimura, Makoto Koide, Masahide Iwai, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Hiroki Kawano, Katayama Yoshio, Toshimitsu Matsui

  第77回日本血液学会, Oct. 2015, Japanese, 日本血液学会, 金沢, Domestic conference

  Oral presentation


• A retrospective study evaluating clinical bleeding score and factor XＩＩＩ in acquired hemorrhage

  Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kawano, Akiko Sada, Akitada Ichinose, Katayama Yoshio

  第77回日本血液学会, Oct. 2015, Japanese, 日本血液学会, 金沢, Domestic conference

  Oral presentation


• Lympho-hematopoetic Microvironment Regulated by Inter-oran Communication

  Katayama Yoshio

  44th Annual Scientific Meeting of the ISEH, Sep. 2015, English, International Society for Experimental Hematology, 京都, Domestic conference

  [Invited]

  Invited oral presentation


• 骨を中心とした他臓器関連：その一時的歪みの臨床応用と破綻による造血器疾患

  Katayama Yoshio

  日本骨代謝学会学術集会, Jul. 2015, Japanese, 日本骨代謝学会, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• Lympho-hematopoetic microvironment regulated by inter-oran communication

  Katayama Yoshio

  48th Annual Meeting of the Japanese Society of Developmental Biologists Symposium 6:Cell-cell interaction in tissue stem cell regulation, Jun. 2015, English, 日本発生生物学会, 茨城, Domestic conference

  [Invited]

  Invited oral presentation


• Mobilization of Hematooietic Stem Cells

  Katayama Yoshio

  The 37th Annual Meeting of the Japan Society for Hematopoietic, Mar. 2015, Japanese, 日本造血細胞移植学会, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• Microenvironment-intrinsic leukemia:oerview

  Katayama Yoshio

  The 37th Annual Meeting of the Japan Society for Hematopoietic, Mar. 2015, Japanese, 日本造血細胞移植学会, 神戸, Domestic conference

  Oral presentation


• Regulation of lympho-hematopoetic microenvironment by inter-organ communication

  Katayama Yoshio

  日本免疫学会総会, Dec. 2014, English, 日本免疫学会, 京都, Domestic conference

  [Invited]

  Invited oral presentation


• Hematopoiesis and Stem Cells:Microenvironment,Cell Adhesion and Stromal Stem Cells:Civersity of the Hematopoietic Stem Cell Niche

  Yuko Kawano, Chie Fukui, Kanako Wakahashi, Shinichi Ishi, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satoshi Uematsu, Sizuo Akira, Toshimitsu Uede, Shuh Narumi, Toshimitsu Matsui, Katayama Yoshio

  56th American Society Hematolory of Annual Meeting and Exposition, Dec. 2014, English, American Society of Hematology, San Francisco, USA, International conference

  Oral presentation


• Lympho-hematopoetic microenvironment regulated by inter-organ communication

  Katayama Yoshio

  Recent Advances in Immunology and Inflammation 2014, Nov. 2014, English, 九州大学 生体防御医学研究所, 福岡, Domestic conference

  [Invited]

  Invited oral presentation


• 骨を頂点とした他臓器関連に支えられる免疫・代謝システム

  Katayama Yoshio

  第35回日本肥満学会, Oct. 2014, Japanese, 日本肥満学会, 宮崎, Domestic conference

  [Invited]

  Invited oral presentation


• Recurrence of large-vessel vasculitis and development of Sweet syndrome after 5-azacytidine

  Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kwano, Akiko Sada, Kentaro Minagawa, Katayama Yoshio

  The 76th Annual Meeting of the Japanese Society of Hematology, Oct. 2014, Japanese, 日本血液学会, 大阪, Domestic conference

  Poster presentation


• An Extremely indolent EBV-positive diffuse large B-cell lymphoma of the elderly

  Takao Kashiwagi, Kentaro Minagawa, Hiroki Kawano, Tomohide Suzuki, Shinichi Ishii, Kanako Wakahashi, Yuko Kawano, Katayama Yoshio, Sayaka Kashiwagi, Yoshihiro Nakagawa, Takuma Suzuki, Tadahiro Inagaki, Minoru Kishi, Tamaki Hirata, Sachiko Kimura, Yasuo Higuchi, Makoto Koide, Masahide Iwai, Toshimitsu Matsui

  The 76th Annual Meeting of the Japanese Society of Hematology, Oct. 2014, Japanese, 日本血液学会, 大阪, Domestic conference

  Poster presentation


• A case of B-cell prolymphocytic leukemia that was successfully treated with ituximab

  Sachiko Kimura, Toshimitsu Matsui, Kentaro Minagawa, Eri Arimoto, Sayaka Kashiwagi, Yoshihiro Nakagawa, Takao Kashiwagi, Makoto Koide, Kanako Wakahashi, Tomohide Suzuki, Shinichi Ishi, Hiroki Kawano, Katayama Yoshio, Nobuharu Fujii, Yoshinobu Maeda, Mitsune Tanimoto

  The 76th Annual Meeting of the Japanese Society of Hematology, Oct. 2014, Japanese, 日本血液学会, 大阪, Domestic conference

  Poster presentation


• 骨細胞と脂肪組織：骨を頂点とした多臓器連関

  Katayama Yoshio

  第19回アディポサイエンス・シンポジウム, Aug. 2014, Japanese, 日本肥満学会, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• 骨・骨髄による多臓器制御

  Katayama Yoshio

  第32回日本骨代謝学会学術集会, Jul. 2014, Japanese, 日本骨代謝学会, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• 骨による免疫系細胞の制御機構

  Katayama Yoshio

  第35回日本炎症・再生医学会(第1回骨免疫会議), Jul. 2014, Japanese, 日本免疫炎症・再生医学会(日本骨免疫会議), 沖縄, Domestic conference

  [Invited]

  Invited oral presentation


• 多臓器関連に支えられる造血システム

  Katayama Yoshio

  第101回近畿血液学地方回, Jun. 2014, Japanese, 近畿血液学地方会, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• 骨による免疫と脂肪代謝の制御

  Katayama Yoshio

  第87回日本内分泌学会学術総会, Apr. 2014, Japanese, 日本内分泌学会, 福岡, Domestic conference

  [Invited]

  Invited oral presentation


• 交感神経シグナルによる骨髄造血幹細胞の運命制御

  Katayama Yoshio

  第14回抗加齢医学学会総会, Apr. 2014, Japanese, 日本抗加齢医学会, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• Late-onset reversible cardiomypathy without significant lymphocytic infiltration in patients with chronic graft-versus-host disease(GVHD)

  川野 宏樹, 石井 慎一, 鈴木 知秀, 若橋 香奈子, 川野 裕子, 定 明子, 皆川 健太郎, 松井 利充, Katayama Yoshio

  The 36th Annual Meeting of the Japan Society for Hematopoietic Cell Transplantation, Mar. 2014, Japanese, 日本造血細胞移植学会, 沖縄, Japan, Domestic conference

  Poster presentation


• αSMA+Macrophages Skewed From Hematopoietic Stem Cells By Vitamin D3 Intiate Myelofibrosis and Subsequent Osteosclerosis

  Kanako Wakahashi, Kentaro Minagawa, Noboru Asada, Yuko Kawano, Mari Sato, Hiroki Kawano, Akiko Sada, Shigeaki Kato, Kotaro Shide, Kazuya Shimoda, Toshimitsu Matsui, Katayama Yoshio

  55th ASH Annual Meeting and Exposition, Dec. 2013, English, American Society of Hematology, New Orleans, USA, International conference

  Oral presentation


• Gvhd Prophylaxis With Mycophenolate Mofetil and Clacineurin Inhibitor In Allogeneic Hematopoietic Cell Transplantation From HLA-Matche SibligsOr 7-8/8HLA-Matched Unrelated Volunteer Donors;A Japanese,Multicenter,Phase II Trial

  Takahiko Nakane, Hirohisa Nakamae, Saiko Kurosawa, Atsuo Okamura, Mchihiro Hidaka, Takuya Yamashita, Akiko Kohno, Takeshi Saito, Yasutaka Aoyama, Kzuo Hatanaka, Katayama Yoshio, Yakushijin Kimikazu, Tshimitsu Matsui, Akiyoshi Takami, Takuhiro Yamaguchi, Masayuki Hino, Takahiro Fukuda

  55th ASH Annual Meeting and Exposition, Dec. 2013, English, American Society of Hematology, New Orleans, USA, International conference

  Oral presentation


• Tripile-hit lymphoma with t(3;8) (q27;q24)BCL6/MYC fusion gene

  Tomohide Suzuki, Toshimitsu Matsui, Takao Kashiwagi, Masahide Iwai, Seizou Kadowaki, Hiroki Kawano, Kentaro Minagawa, Katayama Yoshio

  The Japanese Society of Hematology, Oct. 2013, Japanese, 日本血液学会, 札幌, Japan, Domestic conference

  Poster presentation


• Role of matrix-embedded osteocytes in hematopoietic stem/progenitor cell niche regulation

  Noboru Asada, Katayama Yoshio, Mri Sato, Kentaro Miangawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano, Akiko Sada, Toshimitsu Matsui, Mitsune Tanimoto

  The Japanese Society of Hematology, Oct. 2013, Japanese, 日本血液学会, 札幌, Japan, Domestic conference

  Oral presentation


• Prostaglandin E2 Regulates Osteoblastic Niche Selectively for Hematopoietic Progenitors through Induction of Osteopontin via EP4 Receptor

  Yuko Kawano, Mari Sato, Noboru Asada, Chie Fukui, Kanako Wakahashi, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satosi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Katayama Yoshio

  ASBMR 2013 Annual Meeting, Oct. 2013, English, American Society for Bone and Mineral Research, Baltimore, USA, International conference

  Poster presentation


• Prostaglandin E2 Regulates Osteoblastic Niche by the induction of osteopontin via EP4 receptor

  Yuko Kawano, Mari Sato, Noboru Asada, Chie Fukui, Kanako Wakahashi, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Katayama Yoshio

  The Japanese Society of Hematology, Oct. 2013, Japanese, 日本血液学会, 札幌, Japan, Domestic conference

  Oral presentation


• HIV-negative,HHV-8-unrelated primary effusion lymphoma-like lymphoma with genotypic infidelity

  Takao Kashiwagi, Kentaro Minagawa, Hiroki Kawano, Tamaki Hirata, Sayaka Kashiwagi, Yoshihiro Nakagawa, Satoshi Kusaka, Takuma Suzuki, Tadahiro Inagaki, Mimoru Kishi, Noriko Miwa, Sachiko Kimura, Miho Takechi, Makoto Koide, Masahide Iwai, Katayama Yoshio

  The Japanese Society of Hematology, Oct. 2013, Japanese, 日本血液学会, 札幌, Japan, Domestic conference

  Poster presentation


• 骨を要とする多臓器間ネットワークとそれに支えられる造血システム

  Katayama Yoshio

  第34回日本炎症・再生医学会, Jul. 2013, Japanese, 日本炎症・再生医学会, 京都, Japan, Domestic conference

  [Invited]

  Nominated symposium


• ステロイド治療が著効したリンパ球浸潤を伴わない心GVHD

  川野 宏樹, 江本 拓央, 森 健茂, Tanaka Hidekazu, Yamashita Tomoya, Hirata Ken-ichi, 若橋 香奈子, 川野 裕子, 定 明子, 皆川 健太郎, 松井 利充, Katayama Yoshio

  The 35th Annual Meeting of the Japan Society for Hematopoietic Cell Transplantation, Mar. 2013, Japanese, The Japan Society for Hematopoietic Cell Transplantation, 金沢, Domestic conference

  Poster presentation


• Very low dose lenalidomide with dexamethasone for elderly patients with multiple myeloma

  皆川 健太郎, 川野 宏樹, 鈴木 琢真, 稲垣 忠洋, 来住 稔, 平田 珠希, 木村 祥子, 武地 美保, 小出 亮, 岩井 正秀, 松井 利充, Katayama Yoshio

  The 74th Annual Meeting of the Japanese Society of Hematology, Oct. 2012, Japanese, The Japanese Society of Hematology, 京都, Domestic conference

  Poster presentation


• Successful management of obstructive jaundice by gallstone in a case of PNH with Eculizumab

  川野 宏樹, 皆川 健太郎, 若橋 香奈子, 川野 裕子, 定 明子, 松井 利充, Shiomi Hideyuki, Ku Yonson, Katayama Yoshio

  The 74th Annual Meeting of the Japanese Society of Hematology, Oct. 2012, Japanese, The Japanese Society of Hematology, 京都, Domestic conference

  Poster presentation


• Osteocytes in the Homeostasis of Remote Organs

  佐藤 真理, 浅田 騰, 皆川 健太郎, 川野 裕子, 川野 宏樹, 若橋 香奈子, 定 明子, 池田 恭治, 松井 利充, Katayama Yoshio

  2012 Annual Meeting of The American Society for Bone and Mineral Research, Oct. 2012, English, The American Society for Bone and Mineral Research, Minneapolis, USA, International conference

  Oral presentation


• Inhibitor-negative severe acquired factor XIII/13 deficiency with aggressive subdural hemorrhage

  川野 宏樹, 山本 大輔, 内橋 義人, 若橋 香奈子, 川野 裕子, 定 明子, 皆川 健太郎, Katayama Yoshio, Kohmura Eiji, 惣宇利 正善, 一瀬 白帝

  The 74th Annual Meeting of the Japanese Society of Hematology, Oct. 2012, Japanese, The Japanese Society of Hematology, 京都, Domestic conference

  Poster presentation


• Association of chronic interstitial pneumonia with chronic neutrophilic leukemia

  鈴木 知秀, 北野 幸, 松井 利充, 皆川 健太郎, 定 明子, Katayama Yoshio, Itoh Tomoo, 羽賀 弘典, 伊藤 功, 門脇 誠三

  The 74th Annual Meeting of the Japanese Society of Hematology, Oct. 2012, Japanese, The Japanese Society of Hematology, 京都, Domestic conference

  Poster presentation


• A novel zinc finger protein TFL suppresses IL-17-dependent T-cell-mediated autoimmune disease.

  皆川 健太郎, 若橋 香奈子, 川野 宏樹, 川野 裕子, 佐藤 真理, 定 明子, Katayama Yoshio, 松井 利充

  The 74th Annual Meeting of the Japanese Society of Hematology, Oct. 2012, Japanese, The Japanese Society of Hematology, 京都, Domestic conference

  Oral presentation


• 骨細胞による遠隔臓器機能の制御 "骨を起点とした新たな臓器間ネットワーク"

  佐藤 真理, Katayama Yoshio

  The 30th Annual Meeting of the Japanese Society for Bone and Mineral Research, Jul. 2012, Japanese, The Japanese Society for Bone and Mineral Research, 東京, Domestic conference

  Oral presentation


• 第一寛解期ALLに対する臍帯血移植の意義 ～単施設長期フォローアップデータ～

  皆川 健太郎, 若橋 香奈子, 川野 裕子, 川野 宏樹, 定 明子, Katayama Yoshio, 松井 利充

  第35回日本造血細胞移植学会, Mar. 2012, Japanese, 日本造血細胞移植学会, 金沢, 第二寛解期(CR2)以降でのALLの移植成績は第一寛解期（CR1）に比べ劣る報告がなされ、ALL CR1の同種移植の重要性は高まっている。しかし、代替ドナーでは非血縁骨髄バンクドナーの移植（UR-BMT）が第一選択で臍帯血移植(CBT)はGVLの弱さから骨髄バンクドナーが得られない状況下でのみ使用されることが多い。一方、移植成績については慢性GvHDなどの移植後晩期TRMを考慮すると、短期間の観察ではその良悪を論ずることは難しい。我々の施設におけるALLの移植データを後方視的に解析し、CBTとUR-BMTの長期移植成績の比較を行った。（結果）2005年から2009年のALLの同種移植施行患者の総数は32名（移植時年齢 17～68, 中央値47.5歳）であり、そのうちCR1での移植の5年生存率は57.8% (N=21, 観察期間 40日～2,706日、, Domestic conference

  Poster presentation


• The mechanusm of PBSC mobilization

  Katayama Yoshio

  第34回日本造血細胞移植学会, Feb. 2012, Japanese, 日本造血細胞移植学会, 大阪, Domestic conference

  Invited oral presentation


• Osteocytes Embedded Inside Bone Are Essential for G-CSF-InducedHematopoietic Stem/Progenitor Mobilization

  淺田 騰, Katayama Yoshio, 佐藤 真理, 皆川 健太郎, 若橋 香奈子, 川野 宏樹, 川野 裕子, 定 明子, 池田 恭治, 松井 利充, 谷本 光音

  第53回米国血液学会, Dec. 2011, English, 米国血液学会, サンディエゴ, アメリカ, International conference

  Oral presentation


• Rituximab prior to local radiotherapy prevents from relapse in ocular adnexal MALT lymphoma

  川野 裕子, Sasaki Ryohei, 橋本 直樹, 若橋 香奈子, 川野 宏樹, 淺田 騰, 定 明子, 皆川 健太郎, Katayama Yoshio, 西村 英輝, Yoshida Kenji, Miyawaki Daisuke, Ejima Yasuo, 安積 淳, Sugimura Kazuro, 松井 利充

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Oral presentation


• Regulation of hematopoietic microenvironment by diverse organs-Everything has begun with a simpre bedside qustion-

  Katayama Yoshio

  第73回日本血液学会学術集会, Oct. 2011, English, 日本血液学会, 愛知, Domestic conference

  Invited oral presentation


• Histiocytic sarcoma with two immunohistopathologically distinct populations

  Wakahashi Kanako, Kawano Yuko, Kawano Hiroki, Minagawa Kentaro, Sada Akiko, Shimoyama Manabu, Katayama Yoshio, Yoshida Kenji, Sasaki Ryohei, Itoh Tomoo, Yokozaki Hiroshi, Hayashi Yoshitake, Matsui Toshimitsu

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Poster presentation


• Differential phosphoproteome profiling in FIP1L1-PDGFRA negative hypereosinophilic syndrome

  定 明子, 杉山 尚之, 石濱 泰, 但馬 史人, 太田 秀一, 今井 陽俊, 若橋 香奈子, 川野 裕子, 川野 宏樹, 佐藤 真理, 皆川 健太郎, Katayama Yoshio, 松井 利充

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Oral presentation


• Critical regulation of stromal-dependent lymphopoiesis by bone-buried osteocytes

  佐藤 真理, 皆川 健太郎, 川野 裕子, 川野 宏樹, 淺田 騰, 若橋 香奈子, 定 明子, 松井 利充, Katayama Yoshio

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Oral presentation


• A novel feedback mechanism by ephrin-B1/B2 in T cell activation

  川野 宏樹, Katayama Yoshio, 皆川 健太郎, 下山 学, Mark Henkemeyer, 松井 利充

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Oral presentation


• A novel activated lymphocyte marker TFL is highly expressed in follicular lymphoma but less in DLBCL

  皆川 健太郎, 若橋 香奈子, 川野 宏樹, 川野 裕子, 佐藤 真理, 定 明子, Katayama Yoshio, 田丸 淳一, 木崎 昌弘, 松井 利充

  第73回日本血液学会学術集会, Oct. 2011, Japanese, 日本血液学会, 愛知, Domestic conference

  Oral presentation


• Pharmacokinetics-based optimal dose prediction of mycophenolate moretil in unrelated hematopoietic cell transplantation:proposal of strategies depending on donor source

  若橋 香奈子, 山森 元博, 皆川 健太郎, 川野 宏樹, 川野 裕子, 定 明子, Katayama Yoshio, 松井 利充

  第37回ヨーロッパ骨髄移植学会, Apr. 2011, English, ヨーロッパ骨髄移植学会, パリ, フランス, International conference

  Poster presentation


• Establishment of PK-based MMF dosing in hematopoietic cell transplantation:Correlation of mycophenolic acid exposure to clinical outcome

  若橋 香奈子, 山森 元博, 皆川 健太郎, 川森 有里子, 川野 宏樹, 川野 裕子, 西川 真一朗, 下山 学, 定 明子, Katayama Yoshio, 松井 利充

  第33回日本造血細胞移植学会, Mar. 2011, Japanese, 日本造血細胞移植学会, 愛媛, Domestic conference

  Others


• A Nvel Feedback Mechanism by Ephrin-B1/B2 In T Cell Activation:Concentration-Dependent Switch From Cosimulation toInhibtion

  川野 宏樹, Katayama Yoshio, 皆川 健太郎, 下山 学, Mark Henjemeyer, 松井 利充

  52nd ASH ANNUAL MEETING AND EXPOSITION, Dec. 2010, English, The American Society of Hematology, オーランド, アメリカ, International conference

  Oral presentation


• Expressiom Pttern of a novel activated lymphocyte gene TFL at6q25 in malignant lymphoma

  皆川 健太郎, 田丸 淳一, 川森 有里子, 川野 宏樹, 川野 裕子, 若橋 香奈子, Katayama Yoshio, 木崎 昌弘, 松井利充

  第72回日本血液学会学術集会, Sep. 2010, Japanese, 日本血液学会, 神奈川, Domestic conference

  Oral presentation


• VITAMIN D receptor is essential for neuronal control of hematopoietic stem cell niche

  Yuriko Kawamori, Katayama Yoshio, Noboru Asada, Kentaro Minagawa, Mari Sato, Atsuo Okamura, Manabu Shimoyama, Kimie Nakagawa, Toshio Okano, Mitsune Tanimoto, Shigeaki Kato, Toshimitsu Matsui

  第72回日本血液学会総会, Sep. 2010, Japanese, 日本血液学会, 横浜, Domestic conference

  Oral presentation


• Fatal H1N1 influenza infection in allogeneic stem cell transplantation

  Shinichi Ishii, Manabu Shimoyama, Kanako Wakahashi, Yuko Kawano, Hiroki Kawano, Noboru Asada, Yuriko Kawamori, Shinichiro Nishikawa, Kentaro Minagawa, Akiko Sada, Atsuo Okamura, Katayama Yoshio, Katsuya Yamamoto, Akiko Makino, Shinya Kyoko, Kiyoshi Mori, Yokozaki Hiroshi, Toshimitsu Matsui

  第72回日本血液学会総会, Sep. 2010, Japanese, 日本血液学会, 横浜, Domestic conference

  Poster presentation


• VITAMIN D RECEPTOR IS ESSENTIAL FOR NEURONAL CONTROL OF HEMATOPOIETIC STEM CELL NICHE

  川森 有里子, Katayama Yoshio, 淺田 騰, 皆川 健太郎, 佐藤 真理, 岡村 篤夫, 下山 学, 中川 きみえ, 岡野 としお, 谷本 みつね, 加藤 しげあき, 松井利充

  The European Hematology Association, Jun. 2010, English, The European Hematology Association, バルセロナ, スペイン, International conference

  Oral presentation


• A new alternative strategy for stage I imatinib-sensitive testicular seminoma; lessons from a case associated with Philadelphia-positive acute lymphoblastic leukemia

  岡村 篤夫, 若橋 香奈子, 石井 慎一, 川野 宏樹, 川森 有里子, 淺田 騰, 西川 真一郎, 皆川 健太郎, 下山 学, Katayama Yoshio, 山本 克也, 松井利充

  第8回日本臨床腫瘍学会学術集会, Mar. 2010, Japanese, 日本臨床腫瘍学会, 東京, Domestic conference

  Poster presentation


• 急性GVHD予防薬ミコフェノール酸モフェチル(MMF)至適投与法の確立に関する研究（第4報）

  岡村 篤夫, 若橋 香奈子, 川野 宏樹, 川野 裕子, 川森 有里子, 淺田 騰, 竹腰 久容, 中田 登紀江, 西川 真一郎, 皆川 健太郎, 定 明子, 山本 克也, 下山 学, Katayama Yoshio, 松井 利充

  第32回日本造血細胞移植学会, Feb. 2010, Japanese, 日本造血細胞移植学会, 浜松, Domestic conference

  Oral presentation


• Imatinibが奏効したKIT+精巣原発セミノーマを合併したPh+ALL

  石井 慎一, 岡村 篤夫, 若橋 香奈子, 下山 学, Katayama Yoshio, 松井 利充

  第92回近畿血液学地方会, Dec. 2009, Japanese, 近畿血液地方学会, 京都, Domestic conference

  Oral presentation


• AML carrying duplication of isodicentric chromosome 21,idic(21)(q11.2),leading to pentasomy21q

  下山 学, 山本 克也, 西川 真一郎, 皆川 健太郎, 岡村 篤夫, Katayama Yoshio, 松井 利充

  第71回日本血液学会学術集会, Oct. 2009, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• Therapy-related,mixed phenotype acute leukemia with t(1;21)(q36;q22)and RUNX1 rearrangement

  山本 克也, 川野 裕子, Katayama Yoshio, 下山 学, 松井 利充

  第71回日本血液学会学術集会, Oct. 2009, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• A novel zinc finger protein, p58TFL at P-bodies inhibits human leukemia/lymphoma cell growth

  皆川 健太郎, Katayama Yoshio, 西川 真一郎, 山本 克也, 定 明子, 岡村 篤夫, 下山 学, 松井 利充

  第71回日本血液学会総会, Oct. 2009, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• Research on bone, impact on hematology

  Katayama Yoshio

  第27回日本骨代謝学会学術総会, Jul. 2009, Japanese, 日本骨代謝学会, 大阪, Domestic conference

  Invited oral presentation


• ハイリスク郡中高悪性度非ホジキンリンパ腫の第1寛解期におけるup-front自家末梢血幹細胞移植併用大量化学療法の意義

  岡村 篤夫, 小野 香奈子, 定 明子, 皆川 健太郎, Katayama Yoshio, 下山 学, 松井 利充

  第7回日本臨床腫瘍学会学術集会, Mar. 2009, Japanese, 日本臨床腫瘍学会, 名古屋, Domestic conference

  Poster presentation


• ハイリスク群中高悪性度非ホジキンリンパ腫の第１寛解期におけるup-front自家末梢血幹細胞移植併用大量化学療法の意義

  Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第7回日本臨床腫瘍学会学術集会, Mar. 2009, Japanese, 日本臨床腫瘍学会, 名古屋, Domestic conference

  Poster presentation


• 造血幹細胞移植後の類洞閉塞症候群に対するデフィブロタイドの有効性の検討

  Yakushijin Kimikazu, Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第31回日本造血細胞移植学会総会, Feb. 2009, Japanese, 日本造血細胞移植学会, 札幌, Domestic conference

  Oral presentation


• 急性GVHD予防薬としてのミコフェノール酸モフェチル(MMF)至適投与法の確立に関する研究

  Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第31回日本造血細胞移植学会総会, Feb. 2009, Japanese, 日本造血細胞移植学会, 札幌, Domestic conference

  Oral presentation


• The Promising Strategy of Mycophenolate Mofetil Dosing to Prevent Moderate- to Severe-Acute Graft-Versus-Host Disease

  Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第50回米国血液学会年次総会, Dec. 2008, English, 米国血液学会, サンフランシスコ, 米国, International conference

  Poster presentation


• Hodgkinリンパ腫関連血球貪食症候群を併発した骨髄異形成症候群

  Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Hayashi Yoshitake, Itoh Tomoo, Matsui Toshimitsu

  第90回近畿血液学地方会, Nov. 2008, Japanese, 日本血液学会, 神戸, Domestic conference

  Oral presentation


• Sequential measurement of portal flow is helpful for assessment of SOS treatment with defibrotide

  Yakushijin Kimikazu, Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• Unbalanced translocation der(5;19)(p10;q10) is a novel and recurrent cytogenetic aberration in MDS

  Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• Effectiveness of cord blood transplant for adult acute lymphoblastic leukemia in CR

  Yakushijin Kimikazu, Okamura Atsuo, Katayama Yoshio, Shimoyama Manabu, Matsui Toshimitsu

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• Pure red cell aplasia with primary screlosing cholangitis improved after liver transplantation

  Yakushijin Kimikazu, Okamura Atsuo, Shimoyama Manabu, Katayama Yoshio, Matsui Toshimitsu, Ito Mitsuhiro, Ku Yonson

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• The promising strategy of MMF administration with 3-times daily after allogeneic transplantation

  Okamura Atsuo, Shimoyama Manabu, Katayama Yoshio, Sakaeda Toshiyuki, Hirai Midori, Matsui Toshimitsu

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Poster presentation


• FISH of a possible tumor suppressor gene of malignant lymphoma at 6q25

  Okamura Atsuo, Shimoyama Manabu, Katayama Yoshio, Matsui Toshimitsu

  第70回日本血液学会総会, Oct. 2008, Japanese, 日本血液学会, 京都, Domestic conference

  Oral presentation


• S9 骨免疫と再生 「造血幹細胞ニッチ制御と骨代謝」

  Katayama Yoshio

  第29回 日本炎症・再生医学会, Jul. 2008, Japanese, 日本炎症・再生医学会, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• Rac 活性化分子Dock2の造血幹・前駆細胞における役割

  Matsui Toshimitsu, Katayama Yoshio

  第6回 幹細胞シンポジウム, May 2008, Japanese, 幹細胞シンポジウム, 東京, Domestic conference

  Poster presentation


• 造血幹細胞のゆりかごを揺らす手

  KATAYAMA YOSHIO

  第７回 血液フォーラム２１, Mar. 2007, Japanese, 血液フォーラム２１, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• ＨＬＡ一致血縁者間同種末梢血幹細胞移植後早期に血小板輸血不応、体重増加、高ビリルビン血症を来たした急性リンパ性白血病の一例

  SHIMOYAMA MANABU, KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第3回 Practical Hematology, Feb. 2007, Japanese, Practical Hematology, 京都, Domestic conference

  Oral presentation


• 術前の局所放射線照射領域に放射線肺臓炎を合併した同種骨髄移植症例の一例

  SHIMOYAMA MANABU, KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第２９回日本造血細胞移植学会総会, Feb. 2007, Japanese, 日本造血細胞移植学会, 福岡, Domestic conference

  Poster presentation


• ドナー高齢化に伴う異性間移植キメリズム解析の問題点

  SHIMOYAMA MANABU, KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第２９回日本造血細胞移植学会総会, Feb. 2007, Japanese, 日本造血細胞移植学会, 福岡, Domestic conference

  Poster presentation


• Pharmacodynamicsに基づく急性GVHD/生着促進を目的としたミコフェノール酸モフェチル(MMF)投与法の確立に関する研究

  SHIMOYAMA MANABU, KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第２９回日本造血細胞移植学会総会, Feb. 2007, Japanese, 日本造血細胞移植学会, 福岡, Domestic conference

  Poster presentation


• 親はかわいい我が子に旅をさせる 造血細胞の骨髄から末梢血への動員メカニズム

  KATAYAMA YOSHIO

  日本分子生物学会2006フォーラム シンポジウム, Dec. 2006, Japanese, 日本分子生物学会, 名古屋, Domestic conference

  [Invited]

  Invited oral presentation


• 旅する造血幹細胞とその水先案内人−造血幹細胞の骨髄からの出入りのメカニズム−

  KATAYAMA YOSHIO

  ２１世紀COEセミナー, Nov. 2006, Japanese, 大阪大学病理学, 大阪, Domestic conference

  [Invited]

  Invited oral presentation


• 旅する造血幹細胞とその水先案内人

  KATAYAMA YOSHIO

  第５回 血液腫瘍学術講演会, Nov. 2006, Japanese, 血液腫瘍学術講演会（浜松）, 静岡, Domestic conference

  [Invited]

  Invited oral presentation


• 旅する造血幹細胞とその水先案内人

  KATAYAMA YOSHIO

  第１３回 福岡血液研究会, Nov. 2006, Japanese, 福岡血液研究会, 福岡, Domestic conference

  [Invited]

  Invited oral presentation


• 生着不全症例の臍帯血ミニ移植による救済法

  SHIMOYAMA MANABU, KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第８６回近畿血液学地方会, Nov. 2006, Japanese, 近畿血液学地方会, 和歌山, Domestic conference

  Oral presentation


• 好中球CD44はE-セレクチンのリガンドである

  KATAYAMA YOSHIO

  第68回 日本血液学会・第４８回 日本臨床血液学会合同総会, Oct. 2006, Japanese, 日本血液学会・日本臨床血液学会, 福岡, Domestic conference

  Oral presentation


• t(7;9)(q22;q34)転座は急性骨髄性白血病における新たな再発性の染色体異常である

  KATAYAMA YOSHIO, MATSUI TOSHIMITSU

  第68回 日本血液学会・第４８回 日本臨床血液学会合同総会, Oct. 2006, Japanese, 日本血液学会・日本臨床血液学会, 福岡, Domestic conference

  Poster presentation


• 旅する造血幹細胞とその水先案内人

  KATAYAMA YOSHIO

  学術講演会, Jul. 2006, Japanese, 京都大学小児科, 京都, Domestic conference

  [Invited]

  Invited oral presentation


• 造血幹細胞と骨インターフェースのゲノム学

  KATAYAMA YOSHIO

  第２４回日本骨代謝学会学術集会, Jul. 2006, Japanese, 日本骨代謝学会, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• 造血幹細胞が寄り道するお店は白血病細胞にも魅力的？

  KATAYAMA YOSHIO

  第１回合同班会議プログラム, Jun. 2006, Japanese, JALSG班会議, 名古屋, Domestic conference

  [Invited]

  Invited oral presentation


• 旅する造血幹細胞とその水先案内人

  KATAYAMA YOSHIO

  第１回 先端医療フォーラム, May 2006, Japanese, 先端医療フォーラム, 岡山, Domestic conference

  [Invited]

  Invited oral presentation


• 親はかわいい我が子に旅をさせる−造血幹細胞の骨髄から末梢血への動員メカニズム−

  KATAYAMA YOSHIO

  第４回先端血液学セミナー, May 2006, Japanese, 先端血液学セミナー, 東京, Domestic conference

  [Invited]

  Invited oral presentation


• ケモカイン Fractalkine/CX3CL1 および受容体CX3CR1陽性単球の慢性GVHDの病態への関与

  難波 寛子, KATAYAMA, Yoshio, 品川 克至, 池田 和真, 谷本 光音

  第28回日本造血細胞移植学会総会, Feb. 2006, Japanese, 日本造血細胞移植学会, 東京, Domestic conference

  Oral presentation


• Sulfated colominic acid enhances CXCR4 function and promotes hematopoietic stem/progenitor egress from bone marrow

  Shiro Kubonishi, KATAYAMA, Yoshio, ShinyaYamaguchi, Hirokazu Tamamura, Nobutaka Fujii, Takeshi Watanabe, Fernando Arenzana-Seisdedos, Kazuma Ikeda, Mitsune Tanimoto

  第47回米国血液学会, Dec. 2005, English, 米国血液学会, アトランタ, International conference

  Poster presentation


• Potential Involvement of chemokine fractalkine/CX3CL1 and CX3CR1high monocytes in chronic graft versus host disease

  Noriko Namba, KATAYAMA, Yoshio, Katsuji Shinagawa, Mitsune Tanimoto

  第47回米国血液学会, Dec. 2005, English, 米国血液学会, アトランタ, International conference

  Poster presentation


• Galactocerebrosides, essential for hematopoietic progenitor mobilization, regulate SDF-1 (CXCL12)-mediated attraction to bone

  KATAYAMA, Yoshio, Andres Hidalgo, Paul S Frenette

  第46回米国血液学会, Dec. 2004, English, 米国血液学会, サンディエゴ, International conference

  Oral presentation


• The Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into the bone marrow following transplantation

  KATAYAMA, Yoshio, Andres Hidalgo, Anna Peired, Paul S Frenette

  第45回米国血液学会, Dec. 2003, English, 米国血液学会, サンディエゴ, International conference

  Oral presentation

• International Society for Experimental Hematology


• 日本造血細胞移植学会


• 日本骨免疫学会


• 日本骨代謝学会


• American Society of Hematology


• 日本血液学会


• 日本内科学会

• Dynamism of spaciotemporal trafficking of hematopoietic stem/progenitor cells

  片山 義雄

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2021 - 31 Mar. 2024

  令和3年度までの研究で、骨髄赤芽球から産生される増殖因子（かつ一般的にはリン代謝ホルモンとして知られる）fibroblast growth factor-23 (FGF23）が高濃度で造血幹前駆細胞のFGF受容体に結合することにより、同細胞のケモカイン受容体CXCR4からのシグナルを抑制してケモカインCXCL12による細胞係留作用を断ち切ることで、造血幹前駆細胞が骨髄から遊離しやすくなることを確認した。この際、FGF23の結合は細胞表面上のCXCR4の発現強度やCXCL12蛋白の結合強度には全く影響を与えておらず、ほぼ細胞内シグナルの変化のみでその効果を発揮していた。また、食餌中のω3脂肪酸、特にeicosapentaenoic acid (EPA）が骨髄幼若好中球の受容体型転写因子PPARδのリガンドとして働き、骨髄血管透過性抑制因子angiopoietin-like protein 4（Angptl4）を産生させ、骨髄から造血幹前駆細胞の末梢血への動員を抑制していることも確認した。これらの知見は、骨髄有核細胞の大部分を占める骨髄球系細胞と赤芽球系細胞が、それらの親とも言える造血幹細胞の位置的運命制御を強力に行なっていることを示している。令和4年度にはこれらの機構が骨髄異形成症候群や骨髄増殖性疾患モデルでの病態形成に寄与しているかどうかを検討する予定である。 これらに加えて、血管内皮細胞に強く発現し、造血細胞動員時に骨髄球系細胞で発現が変化することを我々独自に捉えている分子 adrenomedullin（Adm）について、全身性ノックアウトマウスとfloxマウスを令和3年度に作成した。令和4年度には、造血幹前駆細胞の移動メカニズムにおけるAdmの作用についてもこれら新たなマウスモデルを用いて検討を進めていく。


• 骨髄造血大環境としての骨組織の解析

  片山 義雄

  科学研究費補助金／基盤研究(B), Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• 内分泌器官としての骨髄の評価とその神経支配の解明

  片山 義雄

  学術研究助成基金助成金／挑戦的研究（萌芽）, Apr. 2017 - Mar. 2019, Principal investigator

  Competitive research funding


• Transformed follicular lymphoma (TFL) predicts outcome in advanced endometrial cancer

  Wakahashi Senn, Sudo Tamotsu, Katayama Yoshio, Matsuo Keitaro, Kawakami Fumi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2015 - 31 Mar. 2018

  Background: Transformed follicular lymphoma (TFL) was identified, as a candidate tumor suppressor gene that contributes to cell-cycle arrest through regulation of Rb phosphorylation, but the clinical impact of TFL is unknown. The goal of this study was to evaluate the prognostic significance of TFL expression in advanced endometrial cancer. Results: There were 24 TFL-low cases (23.3%) and the 10- PFS and OS in these cases were lower than those for patients with normal TFL expression in univariate analysis (PFS, P = .003; OS, P = .106). In multivariate analysis, TFL status was a significant predictor for PFS (HR 2.76, 95% CI 1.45-5.28; P = .002) and OS (HR 1.94, 95% CI 0.91-4.11; P = .085). Among 41 ERα-low patients, 10-year PFS was significantly lower in 15 TFL-low cases (multivariate analysis, HR 4.70, 95% CI 1.68-13.20, P = .003). Conclusions: We identified TFL as a strong independent prognostic factor, regardless of ERα status.


• 造血制御中枢としての骨組織の評価

  片山 義雄

  科学研究費補助金／基盤研究(B), Apr. 2015 - Mar. 2018, Principal investigator

  Competitive research funding


• 造血幹細胞ニッチ制御モジュールの加齢性変化と造血システム異常の関連

  片山 義雄

  科学研究費補助金／新学術領域研究, Apr. 2015 - Mar. 2017, Principal investigator

  Competitive research funding


• 五感による造血制御：かおり

  片山 義雄

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2017, Principal investigator

  Competitive research funding


• 造血幹細胞の異系列分化と造血器疾患との関連

  片山 義雄

  科学研究費補助金／新学術領域研究, Apr. 2013 - Mar. 2015, Principal investigator

  Competitive research funding


• さきがけ「骨を要とする多臓器恒常性維持機構の解明」

  片山 義雄

  科学技術振興機構, 戦略的創造研究推進事業 個人型研究さきがけ, 2015, Principal investigator

  Competitive research funding


• さきがけ「骨を要とする多臓器恒常性維持機構の解明」

  片山 義雄

  戦略的創造研究推進事業 個人型研究さきがけ, 2014, Principal investigator

  Competitive research funding


• さきがけ「骨を要とする多臓器恒常性維持機構の解明」

  片山 義雄

  戦略的創造研究推進事業 個人型研究さきがけ, 2013, Principal investigator

  Competitive research funding


• さきがけ「骨を要とする多臓器恒常性維持機構の解明」

  片山 義雄

  戦略的創造研究推進事業 個人型研究さきがけ, 2012, Principal investigator

  Competitive research funding


• 造血制御中枢としての骨組織の評価

  片山 義雄

  科学研究費補助金／基盤研究(B), 2011, Principal investigator

  Competitive research funding


• 骨組織による神経を介したリンパ球分化増殖制御機構の解明

  片山 義雄

  科学研究費補助金／新学術領域研究, 2011, Principal investigator

  Competitive research funding


• カベオラ膜結合型ビタミンＤ受容体を介する神経－骨－免疫系による造血制御の解明

  松井 利充

  科学研究費補助金／基盤研究(C), 2009

  Competitive research funding


• 新規Ｚｎフィンガーファミリーがん抑制遺伝子を介する多段階発がんモデルの確立

  松井 利充

  科学研究費補助金／特定領域研究, 2008

  Competitive research funding


• 骨免疫調節ホルモン／サイトカインによる造血制御メカニズムの解明

  松井 利充

  科学研究費補助金／萌芽研究, 2007

  Competitive research funding


• 骨髄造血幹細胞の末梢血への動員メカニズムにおけるＰＧＥ２の役割に関する検討

  片山 義雄

  科学研究費補助金／基盤研究(C), 2007, Principal investigator

  Competitive research funding


• 硫酸化糖脂質による造血幹細胞移動の制御

  片山 義雄

  科学研究費補助金／若手研究(B), 2006, Principal investigator

  Competitive research funding