Research activity information

• Jun. 2018 公益社団法人 新化学技術推進協会, 第7回JACI/GSC シンポジウム GSCポスター賞, Dehydrogenation of hydroquinones to benzoquinones and naphthoquinones by activated carbon under O2 atmosphere.

  Sanghun Kim, Masahiko Hayashi

  Japan society

• Non-aerobic and One-pot Synthesis of Carbazoles from Cyclohexanones and Arylhydrazines

  Keigo Miki, Ryosuke Matsubara, Masahiko Hayashi

  The reaction of cyclohexanones with phenylhydrazines proceeded under an ethylene atmosphere in the presence of a catalytic amount of Pd/C and equimolar amount of p-toluenesulfonic acid monohydrate to afford a variety of substituted carbazoles in good to high yields. The present reaction was carried out under completely non aerobic conditions, which is in contrast with the previously reported aerobic system. This protocol was also applied to the synthesis of symmetrical carbazoles using hydrazine monohydrate in place of phenylhydrazines. The reaction will proceed in a manner similar to Fischer indole synthesis, involving a [3,3]-sigmatropic rearrangement and advancing with 1,2,3,4-tetrahydrocarbazole as an intermediate.

  Georg Thieme Verlag KG, Jan. 2025, Synthesis

  Scientific journal


• Regiodivergent Desymmetrization of meso-4,5-Epoxycyclohex-1-ene

  Yiwei Wang, Miho Wakiya, Ryosuke Matsubara, Masahiko Hayashi

  American Chemical Society (ACS), Dec. 2024, The Journal of Organic Chemistry, 90(1) (1), 840 - 845

  Scientific journal


• Facile Synthesis of 2- and 3-Substituted Indoles Using a Catalytic Amount of Pd/C and 1-Octene System

  Xu Dong, Ryosuke Matsubara, Masahiko Hayashi

  Herein, novel and efficient synthesis of 3- and 2-substituted indoles starting from 2-(2-nitro-1-phenylethyl or 2-nitro-1-alkyl)cyclohexanones and 1,4-diketones, respectively using a catalytic amount of Pd/C and 1-octene system is reported.

  Georg Thieme Verlag KG, Nov. 2024, Synthesis

  Scientific journal


• Triazolium-Catalyzed Metal-Free Photochemical Reduction of CO₂ into Formate

  Weibin Xie, Masaaki Fuki, Ayana Sukegawa, Kenji Okunaka, Masahiko Hayashi, Yasuhiro Kobori, Ryosuke Matsubara

  American Chemical Society (ACS), Nov. 2024, ACS Sustainable Chemistry & Engineering, 12(47) (47), 17328 - 17335

  Scientific journal


• Synthesis of 2-(Pyridin-2-yl)phenols and 2-(Pyridin-2-yl)anilines

  Keigo Miki, Katsumi Maeda, Ryosuke Matsubara, Masahiko Hayashi

  American Chemical Society (ACS), Apr. 2024, The Journal of Organic Chemistry, 89(8) (8), 5797 - 5810, English

  [Refereed]

  Scientific journal


• Sensitizer-Free Photochemical Regeneration of Benzimidazoline Organohydride

  Ryosuke Matsubara, Tatsuhiro Harada, Weibin Xie, Tatsushi Yabuta, Jiasheng Xu, Masahiko Hayashi

  American Chemical Society (ACS), Aug. 2023, The Journal of Organic Chemistry, 88(17) (17), 12276 - 12288

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Photophysical and electrochemical properties of 9-naphthyl-3,6-diaminocarbazole derivatives and their application as photosensitizers

  Ryosuke Matsubara, Huilong Kuang, Tatsushi Yabuta, Weibin Xie, Masahiko Hayashi, Eri Sakuda

  Elsevier BV, Jun. 2023, Journal of Photochemistry and Photobiology, 15, 100176 - 100176

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• One-Pot Synthesis of 3-Substiuted Indoles from 2-(2-Nitro-1-phenylethyl)cyclohexanone Derivatives

  Yangjin Kuang, Katsumi Maeda, Ryosuke Matsubara, Masahiko Hayashi

  American Chemical Society (ACS), Apr. 2023, The Journal of Organic Chemistry

  Scientific journal


• Metal-free reduction of CO2 to formate using a photochemical organohydride-catalyst recycling strategy.

  Weibin Xie, Jiasheng Xu, Ubaidah Md Idros, Jouji Katsuhira, Masaaki Fuki, Masahiko Hayashi, Masahiro Yamanaka, Yasuhiro Kobori, Ryosuke Matsubara

  Increasing levels of CO2 in the atmosphere is a problem that must be urgently resolved if the rise in current global temperatures is to be slowed. Chemically reducing CO2 into compounds that are useful as energy sources and carbon-based materials could be helpful in this regard. However, for the CO2 reduction reaction (CO2RR) to be operational on a global scale, the catalyst system must: use only renewable energy, be built from abundantly available elements and not require high-energy reactants. Although light is an attractive renewable energy source, most existing CO2RR methods use electricity and many of the catalysts used are based on rare heavy metals. Here we present a transition-metal-free catalyst system that uses an organohydride catalyst based on benzimidazoline for the CO2RR that can be regenerated using a carbazole photosensitizer and visible light. The system is capable of producing formate with a turnover number exceeding 8,000 and generates no other reduced products (such as H2 and CO).

  Mar. 2023, Nature chemistry, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diboration of Alkynes Accelerated by Synergistic Effects of Ruthenium Complexes and Phenoxides

  Suguru Murakami, Ryosuke Matsubara, Masahiko Hayashi

  Wiley, Nov. 2022, European Journal of Organic Chemistry, 2022(44) (44)

  Scientific journal


• Direct Arylation of Furoxan Using Potassium Aryltrifluoroborates

  Ryosuke Matsubara, Chenlu Dong, Masahiko Hayashi

  The Japan Institute of Heterocyclic Chemistry, 2022, HETEROCYCLES, 104(10) (10), 1770 - 1770

  Scientific journal


• Furoxan Incorporation into C-H Bonds Enabling Nitrogen-Containing Functional Group Installation into the Same.

  Chenlu Dong, Xufeng Zhao, Yuki Katsuragi, Hojin Kim, Masahiko Hayashi, Ryosuke Matsubara

  A C-C bond forming method was developed, whereby a furoxan ring is incorporated into various types of C-H bonds. The protocol not only offers a concise synthetic route to a variety of alkylated furoxan derivatives but also provides an efficient strategy for the insertion of various nitrogen-containing functional groups into C-H bonds via transformation of the resultant furoxan ring.

  Nov. 2021, The Journal of organic chemistry, 86(21) (21), 15807 - 15817, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Borylfuroxans: Synthesis and Applications.

  Weibin Xie, Masahiko Hayashi, Ryosuke Matsubara

  Herein we report the first synthesis of borylfuroxans via the reaction of sulfonylfuroxans with Lewis base-ligated boranes under radical conditions. As a synthetic application, the transformation of borylfuroxans to a range of 1,2-dioximes and their derivatives is demonstrated.

  Jun. 2021, Organic letters, 23(11) (11), 4317 - 4321, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Regiodivergent Desymmetrization Reaction of meso-Azabicycloheptene Providing Two Enantioenriched Structural Isomers.

  Yuxin Zheng, Yanze Huang, Peng Gao, Hongyan Liu, Suguru Murakami, Ryosuke Matsubara, Masahiko Hayashi

  A novel catalytic asymmetric reaction is reported where the regiodivergent desymmetrisation of meso-azabicycloheptene via allylic oxidation using a single chiral copper catalyst produced two different, enantioenriched structural isomers in high optical purity starting from a single compound. The enantioselectivity of the two structurally isomeric compounds was enriched to >99.5% ee after derivatization.

  Apr. 2021, Organic letters, 23(7) (7), 2411 - 2414, English, International magazine

  [Refereed]

  Scientific journal


• Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis.

  Katsumi Maeda, Ryosuke Matsubara, Masahiko Hayashi

  The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

  Mar. 2021, Organic letters, 23(5) (5), 1530 - 1534, English, International magazine

  [Refereed]

  Scientific journal


• Photocatalytic Reductive C-O Bond Cleavage of Alkyl Aryl Ethers by Using Carbazole Catalysts with Cesium Carbonate.

  Tatsushi Yabuta, Masahiko Hayashi, Ryosuke Matsubara

  Methods to activate the relatively stable ether C-O bonds and convert them to other functional groups are desirable. One-electron reduction of ethers is a potentially promising route to cleave the C-O bond. However, owing to the highly negative redox potential of alkyl aryl ethers (Ered < -2.6 V vs SCE), this mode of ether C-O bond activation is challenging. Herein, we report the visible-light-induced photocatalytic cleavage of the alkyl aryl ether C-O bond using a carbazole-based organic photocatalyst (PC). Both benzylic and non-benzylic aryl ethers underwent C-O bond cleavage to form the corresponding phenol products. Addition of Cs2CO3 was beneficial, especially in reactions using a N-H carbazole PC. The reaction was proposed to occur via single-electron transfer (SET) from the excited-state carbazole to the substrate ether. Interaction of the N-H carbazole PC with Cs2CO3 via hydrogen bonding exists, which enables a deprotonation-assisted electron-transfer mechanism to operate. In addition, the Lewis acidic Cs cation interacts with the substrate alkyl aryl ether to activate it as an electron acceptor. The high reducing ability of the carbazole combined with the beneficial effects of Cs2CO3 made this otherwise formidable SET event possible.

  Feb. 2021, The Journal of organic chemistry, 86(3) (3), 2545 - 2555, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Synthesis, structure, and catalytic activity of [Cp*Ru(eta(1)-ArCN)(3)]PF6 complexes

  Suguru Murakami, Ryosuke Matsubara, Masahiko Hayashi

  Feb. 2021, JOURNAL OF ORGANOMETALLIC CHEMISTRY, 933, English

  Scientific journal


• Selective Synthesis of Some Aminosugars via Catalytic Aminohydroxylation of Protected 2,3-Unsaturated d-Gluco- and d-Galacto-2-hexenopyranosides.

  Ippei Fukuhara, Ryosuke Matsubara, Masahiko Hayashi

  The aminohydroxylation of methyl 4,6-di-O-(tert-butyldimethylsilyl)-2,3-unsaturated α-d-glucopyranoside proceeds in the presence of chloramine-T, OsO4 (4 mol %), (DHQ)2PHAL (5 mol %), and triethylbenzylammonium chloride (TEBAC) in both a stereoselective and a regioselective manner to produce protected methyl α-d-mannosamide as the sole product. In contrast, the reaction of methyl 2,3-unsaturated β-d-galactopyranoside under the same conditions produced a mixture of regioisomers, although the stereochemistry was perfectly controlled. The regioisomeric ratio was dependent on the nature of the protecting group and the ligand used.

  Jul. 2020, The Journal of organic chemistry, 85(14) (14), 9179 - 9189, English, International magazine

  [Refereed]

  Scientific journal


• Synthesis and Synthetic Application of Chloro- and Bromofuroxans.

  Ryosuke Matsubara, Akihiro Ando, Hayu Hasebe, Hojin Kim, Takao Tsuneda, Masahiko Hayashi

  Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods. Herein, we report a new synthetic approach for the synthesis of chloro- and bromofuroxans. The starting materials were dichloro- and dibromofuroxans, and the substituents were directly introduced to the furoxan ring in a modular fashion. The synthesized monohalofuroxans served as substrates for the installation of a second substituent to prepare further functionalized furoxans.

  Last, May 2020, The Journal of organic chemistry, 85(9) (9), 5959 - 5972, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on "Build-and-Scrap" Strategy.

  Ryosuke Matsubara, Hojin Kim, Takaya Sakaguchi, Weibin Xie, Xufeng Zhao, Yuto Nagoshi, Chaoyu Wang, Masahiro Tateiwa, Akihiro Ando, Masahiko Hayashi, Masahiro Yamanaka, Takao Tsuneda

  Utilizing radical chemistry, a new general C-C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.

  Feb. 2020, Organic letters, 22(3) (3), 1182 - 1187, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 9-Aryl-3-aminocarbazole as an Environment- and Stimuli-Sensitive Fluorogen and Applications in Lipid Droplet Imaging.

  Ryosuke Matsubara, Tomoaki Kaiba, Akito Nakata, Tatsushi Yabuta, Masahiko Hayashi, Motonari Tsubaki, Takashi Uchino, Eri Chatani

  Environment-sensitive luminophoric molecules have played an important role in the fields of smart materials, sensing, and bioimaging. In this study, it was demonstrated that depending on the substituents, 9-aryl-3-aminocarbazoles can display aggregation-induced emission and solvatofluorochromism, and the operating mechanism was clarified. The application of these compounds to lipid droplet imaging and fluorescent probes for cysteamine was demonstrated.

  May 2019, The Journal of organic chemistry, 84(9) (9), 5535 - 5547, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Activated Carbon-Promoted Dehydrogenation of Hydroquinones to Benzoquinones, Naphthoquinones, and Anthraquinones under Molecular Oxygen Atmosphere.

  Sanghun Kim, Ryosuke Matsubara, Masahiko Hayashi

  We found that the activated carbon-molecular oxygen system promotes the conversion of hydroquinones to benzoquinones, naphthoquinones, and anthraquinones, which are often found in natural products and pharmaceuticals. In particular, the one-pot synthesis of naphthoquinones and anthraquinones involving a Diels-Alder reaction is a useful protocol for this purpose.

  Mar. 2019, The Journal of organic chemistry, 84(5) (5), 2997 - 3003, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A fluorescent naphthalenediimide-alkoxyfuroxan photoinduced nitric oxide donor

  C. P. Seymour, A. Nakata, M. Tsubaki, M. Hayashi, R. Matsubara

  Jan. 2019, Bull. Chem. Soc. Jpn., 92(1) (1), 162 - 169, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• UVA- and Visible-Light-Mediated Generation of Carbon Radicals from Organochlorides Using Nonmetal Photocatalyst.

  Ryosuke Matsubara, Tatsushi Yabuta, Ubaidah Md Idros, Masahiko Hayashi, Fumitoshi Ema, Yasuhiro Kobori, Ken Sakata

  Carbon radicals are reactive species useful in various organic transformations. The C-X bond cleavage of organohalides by photoirradiation is a common method to generate carbon radicals in a controlled fashion. The use of organochloride substrates is still a formidable challenge due to the low reduction potential and the high dissociation energy of the C-Cl bond. In this report, we address these issues by using a nonmetal organic molecule with a relatively simple structure as a photocatalyst. In this catalyst (bis(dimethylamino)carbazole), the amino groups increase both the HOMO and LUMO energy levels, especially in the former. As a result, compared to the parent molecule, the new catalyst shows experimentally red-shifted absorption in the visible region and forms an excited state with better reducing capability. This photocatalyst was used in the reduction of unactivated aryl chlorides and alkyl chlorides in the presence of hydrogen atom donor at room temperature. The catalytic system can also be applied to the coupling of aryl chlorides with electron-rich arene and heteroarenes to affect the C-C bond-forming reactions. Our mechanistic study results support the assumption that carbon radicals are formed from the organochlorides via a single-electron-transfer step.

  Aug. 2018, The Journal of organic chemistry, 83(16) (16), 9381 - 9390, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Photoinduced nitrile formation from O-(arylcarbonyl)oxime: Usage as a photoremovable protective group

  R. Matsubara, U. Md Idros, T. Yabuta, H. Ma, M. Hayashi, K. Eda

  Aug. 2018, ChemPhotoChem, 2, 1012, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Synthesis of sulfonyloxy furoxans via hydroxyfuroxan ammonium salts

  R. Matsubara, Y. Katsuragi, T. Sakaguchi, S. Eguchi, M. Hayashi, A. Ando

  2018, Tetrahedron, 74, 3642 - 3651, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Synthesis of arylamines via non-aerobic dehydrogenation using a palladium/carbon-ethylene system

  Y. Shimomoto, R. Matsubara, M. Hayashi

  2018, Adv. Synth. Catal., 360(17) (17), 3297 - 3305, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Photosensitization of Fluorofuroxans and Its Application to the Development of Visible Light-Triggered Nitric Oxide Donor.

  Christopher Peter Seymour, Rei Tohda, Motonari Tsubaki, Masahiko Hayashi, Ryosuke Matsubara

  Sep. 2017, The Journal of organic chemistry, 82(18) (18), 9647 - 9654, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Inositol Hexakis Phosphate is the Seasonal Phosphorus Reservoir in the Deciduous Woody Plant Populus alba L.

  Yuko Kurita, Kei'ichi Baba, Miwa Ohnishi, Ryosuke Matsubara, Keiko Kosuge, Aya Anegawa, Chizuko Shichijo, Kimitsune Ishizaki, Yasuko Kaneko, Masahiko Hayashi, Toshinobu Suzaki, Hidehiro Fukaki, Tetsuro Mimura

  Sep. 2017, Plant & cell physiology, 58(9) (9), 1477 - 1485, English, Domestic magazine

  [Refereed]

  Scientific journal


• Synthesis of cyanofuroxans from 4-nitrofuroxans via C-C bond forming reactions

  Ryosuke Matsubara, Akihiro Ando, Masahiko Hayashi

  Aug. 2017, TETRAHEDRON LETTERS, 58(34) (34), 3337 - 3340, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dehydrogenative Formation of Resorcinol Derivatives Using Pd/C–Ethylene Catalytic System

  M. Hayashi

  Jun. 2017, International Symposium on Pure & Applied Chemistry 2017 (ISPAC 2017), English

  International conference proceedings


• Synthesis of Enantiomerically Pure (8S,9S,10R,6Z)-Trihydroxyoctadec-6-enoic Acid.

  Jogula Srinivas, Yoichi Namito, Ryosuke Matsubara, Masahiko Hayashi

  We have accomplished the asymmetric synthesis of (8S,9S,10R,6Z)-trihydroxyoctadec-6-enoic acid in optically pure form and determined the absolute configuration of the natural product on the basis of the stereodetermined chiral building block 7, which was prepared by the catalytic enantioselective allylic oxidation of 4,5-epoxycyclohex-1-ene using an S-configured N,N-bidentate ligand-copper catalyst.

  May 2017, The Journal of organic chemistry, 82(10) (10), 5146 - 5154, English, International magazine

  [Refereed]

  Scientific journal


• Recent topics on catalytic asymmetric 1,4-addition

  Masahiko Hayashi, Ryosuke Matsubara

  May 2017, TETRAHEDRON LETTERS, 58(19) (19), 1793 - 1805, English

  [Refereed]

  Scientific journal


• Study on the photo-induced nitric oxide-releasing ability of 4-alkoxy furoxans

  R. Matsubara, S. Takazawa, A. Ando, M. Hayashi, R. Tohda, M. Tsubaki

  Apr. 2017, Asian J. Org. Chem., English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dehydrogenative Formation of Resorcinol Derivatives Using Pd/C-Ethylene Catalytic System.

  Ibrahim Yussif El-Deeb, Tatsuya Funakoshi, Yuya Shimomoto, Ryosuke Matsubara, Masahiko Hayashi

  The conversion of substituted 1,3-cyclohexanediones to the alkyl ethers of resorcinol using a Pd/C-ethylene system is reported. In these reactions, ethylene works as a hydrogen acceptor. The efficient synthesis of resveratrol was achieved using this protocol as a key step. In addition, the direct formation of substituted resorcinols was carried out by adding K2CO3 into the reaction media.

  Mar. 2017, The Journal of organic chemistry, 82(5) (5), 2630 - 2640, English, International magazine

  [Refereed]

  Scientific journal


• Synthesis of alkynyl furoxans. Rare carbon-carbon bond-forming reaction on a furoxan ring

  Ryosuke Matsubara, Shuhei Eguchi, Akihiro Ando, Masahiko Hayashi

  Mar. 2017, ORGANIC & BIOMOLECULAR CHEMISTRY, 15(9) (9), 1964 - 1968, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Synthesis of alkynyl furoxans. Rare carbon-carbon bond-forming reaction on a furoxan ring.

  Ryosuke Matsubara, Shuhei Eguchi, Akihiro Ando, Masahiko Hayashi

  Mar. 2017, Organic & biomolecular chemistry, 15(9) (9), 1965 - 1969, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Conversion of Cyclohexanones to Alkyl Aryl Ethers by Using a Pd/C-Ethylene System

  Ibrahim Yussif El-Deeb, Miaomiao Tian, Tatsuya Funakoshi, Ryosuke Matsubara, Masahiko Hayashi

  Jan. 2017, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017(2) (2), 409 - 413, English

  [Refereed]

  Scientific journal


• Selective Synthesis of Partially Protected d-Talopyranosides and d-Gulopyranosides via Catalytic Asymmetric Dihydroxylation: Multiplier Effects of Substrate Control and Catalyst Control.

  Yoichi Namito, Kyosuke Michigami, Takaaki Nagahashi, Ryosuke Matsubara, Masahiko Hayashi

  Highly selective syntheses of d-talopyranosides and d-gulopyranosides have been achieved by utilizing the multiplier effects of substrate control and catalyst control. Through the combination of an O-benzoyl-protected substrate and the AD-mix-β system, the d-talopyranoside was obtained in a ratio of 96:4. In contrast, the d-gulopyranoside was obtained in a ratio of 3:97 through the use of an O-tert-butyldimethylsilyl-protected substrate and AD-mix-α.

  Dec. 2016, Organic letters, 18(23) (23), 6058 - 6061, English, International magazine

  [Refereed]

  Scientific journal


• Progress of Chiral Schiff Bases with C1 Symmetry in Metal-Catalyzed Asymmetric Reactions.

  Masahiko Hayashi

  Dec. 2016, Chemical record (New York, N.Y.), 16(6) (6), 2708 - 2735, English, International magazine

  [Refereed]

  Scientific journal


• Photoinduced Charge-Transfer State of 4-Carbazolyl-3-(trifluoromethyl)benzoic Acid: Photophysical Property and Application to Reduction of Carbon-Halogen Bonds as a Sensitizer.

  Ryosuke Matsubara, Toshiyuki Shimada, Yasuhiro Kobori, Tatsushi Yabuta, Toshiyuki Osakai, Masahiko Hayashi

  Jul. 2016, Chemistry, an Asian journal, 11(14) (14), 2006 - 10, English, International magazine

  [Refereed]

  Scientific journal


• Synthesis of Furoxans (1,2,5-oxadiazole 2-oxides) from Styrenes and Nitrosonium Tetrafluoroborate in Non-Acidic Media and Mechanistic Study

  Ryosuke Matsubara, Akihiro Ando, Yuta Saeki, Kazuo Eda, Naoki Asada, Tomoaki Tsutsumi, Yong Soon Shin, Masahiko Hayashi

  Jul. 2016, JOURNAL OF HETEROCYCLIC CHEMISTRY, 53(4) (4), 1094 - 1105, English

  [Refereed]

  Scientific journal


• Fluorofuroxans: Synthesis and Application as Photoinduced Nitric Oxide Donors

  Akihiro Ando, Ryosuke Matsubara, Saori Takazawa, Toshiyuki Shimada, Masahiko Hayashi

  Jul. 2016, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 5(7) (7), 886 - 890, English

  [Refereed]

  Scientific journal


• A Concise Synthesis of Asymmetrically 4,5-Disubstituted 9,9-Dimethyl-9H-xanthenes

  Ryosuke Matsubara, Miki Koide, Yong-Soon Shin, Toshiyuki Shimada, Masahiko Hayashi

  Jan. 2015, SYNTHESIS-STUTTGART, 47(2) (2), 187 - 192, English

  [Refereed]

  Scientific journal


• Revisiting the Saito Photochemical Reduction and the Development of a One-Pot Deoxygenation of Alcohols

  Ryosuke Matsubara, Yong-Soon Shin, Toshiyuki Shimada, Masahiko Hayashi

  Oct. 2014, ASIAN JOURNAL OF ORGANIC CHEMISTRY, 3(10) (10), 1054 - 1057, English

  [Refereed]

  Scientific journal


• Asymmetric Synthesis of cis- and trans-2-Aryl-6-methylpyrans from D-Glucose by Arylation and Inversion of Configuration at the C-2 Position

  Kyosuke Michigami, Atsuko Shimazaki, Masahiko Hayashi

  Jan. 2014, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014(1) (1), 244 - 253, English

  [Refereed]

  Scientific journal


• Enantioselective Alkynylation of Trifluoromethyl Ketones Catalyzed by Chiral Schiff Bases

  Vasudevan Dhayalan, Ryo Murakami, Masahiko Hayashi

  Oct. 2013, ASIAN JOURNAL OF CHEMISTRY, 25(13) (13), 7505 - 7508, English

  [Refereed]

  Scientific journal


• Cleavage of 4,6-O-Benzylidene Acetal Using Sodium Hydrogen Sulfate Monohydrate

  Kyosuke Michigami, Manami Terauchi, Masahiko Hayashi

  Jun. 2013, SYNTHESIS-STUTTGART, 45(11) (11), 1519 - 1523, English

  [Refereed]

  Scientific journal


• Practical preparation of chiral keto-imine type ONO Schiff base ligands

  Vasudevan Dhayalan, Ryo Murakami, Masahiko Hayashi

  May 2013, TETRAHEDRON-ASYMMETRY, 24(9-10) (9-10), 543 - 547, English

  [Refereed]

  Scientific journal


• Enantioselective alkylation of aldehydes using dialkylzincs catalyzed by simple chiral diols derived from naturally occurring monosaccharides

  Kyosuke Michigami, Masahiko Hayashi

  May 2013, TETRAHEDRON, 69(21) (21), 4221 - 4225, English

  [Refereed]

  Scientific journal


• Oxidation of Secondary Benzylic Alcohols to Ketones and Benzylic Oxygenation of Alkylarenes with Hydrogen Peroxide in the Presence of Activated Carbon

  Shunsuke Nishida, Masahiko Hayashi

  Jul. 2012, SYNLETT, 23・1683-1685(11) (11), 1683 - 1685, English

  [Refereed]

  Scientific journal


• Synthesis of 2-Arylbenzothiazole Derivatives Based on Activated Carbon/Oxygen Oxidation Followed by Suzuki-Miyaura Coupling

  Vasudevan Dhayalan, Masahiko Hayashi

  Jul. 2012, SYNTHESIS-STUTTGART, 44(14) (14), 2209 - 2216, English

  [Refereed]

  Scientific journal


• Simple Preparation of beta-Amino Alcohols Possessing a tert-Butyl Group at the alpha-Carbon

  James T. Zacharia, Takanori Tanaka, Yumiko Uesaka, Masahiko Hayashi

  Jun. 2012, SYNTHESIS-STUTTGART, 44(11) (11), 1625 - 1627, English

  [Refereed]

  Scientific journal


• HF-Pyridine: A Versatile Promoter for Monoacylation/Sulfonylation of Phenolic Plots and for Direct Conversion of t-Butyldimethylsilyl Ethers to the Corresponding Acetates

  Kyosuke Michigami, Kazuya Yoshimoto, Masahiko Hayashi

  Feb. 2012, CHEMISTRY LETTERS, 41(2) (2), 138 - 139, English

  [Refereed]

  Scientific journal


• Facile synthesis of acacetin-7-O-β-D-galactopyranoside.

  James T Zacharia, Masahiko Hayashi

  Feb. 2012, Carbohydrate research, 348, 91 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones using novel N,N,P-Cu(II) complex

  Y. Ebisu, K. Kawamura, HAYASHI Masahiko

  Feb. 2012, Tetrahedron: Asymmetry, 23・959-964, English

  [Refereed]

  Scientific journal


• O- and N-Glycosidation of D-glycals using Ferrier rearrangement under Mitsunobu reaction conditions. Application to N-nucleoside synthesis

  Kyosuke Michigami, Masahiko Hayashi

  Jan. 2012, TETRAHEDRON, 68(4) (4), 1092 - 1096, English

  [Refereed]

  Scientific journal


• Ni- AND Cu-CATALYZED COUPLING REACTIONS UISING 2-(4,5-DIHYDRO-1H-IMIDAZO-2-YL)PHENOL AS A VERSATILE PHOSPHINE-FREE LIGAND

  Satoshi Haneda, Kazuhiko Sudo, Masahiko Hayashi

  Jan. 2012, HETEROCYCLES, 84(1) (1), 569 - 575, English

  [Refereed]

  Scientific journal


• Imidazole and Imidazoline Derivatives as N-Donor for Nickel-catalyzed Kumada-Tamao-Corriu Coupling

  R. Iwamoto, HAYASHI Masahiko

  Jan. 2012, Heterocycles, 86・713-718, English

  [Refereed]

  Scientific journal


• Formal total synthesis of (-)-oseltamivir phosphate.

  Takanori Tanaka, Qitao Tan, Hiromu Kawakubo, Masahiko Hayashi

  Jul. 2011, The Journal of organic chemistry, 76(13) (13), 5477 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Enantioselective Copper-Catalyzed 1,4-Addition of Dialkylzincs to Enones Followed by Trapping with Allyl Iodide Derivatives

  Kenjiro Kawamura, Hitomi Fukuzawa, Masahiko Hayashi

  Jun. 2011, BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 84(6) (6), 640 - 647, English

  [Refereed]

  Scientific journal


• A facile synthesis of (1S,5R,6S)-5-azido-6-benzyloxycyclohex-2-en-1-ol.

  Takanori Tanaka, Qitao Tan, Kazunari Iwanaga, Masahiko Hayashi

  Feb. 2011, Carbohydrate research, 346(2) (2), 340 - 2, English, International magazine

  [Refereed]

  Scientific journal


• Simple Three Steps Synthesis of Potential Medicine for Metabolic Syndrome

  K. Adachi, K. Michigami, HAYASHI Masahiko

  Dec. 2010, Heterocycles, 82・1・857-865, English

  [Refereed]

  Scientific journal


• Oxidative Transformation of Thiols to Disulfides Promoted by Activated Carbon―Air System

  M. Hayashi, K. Okunaga, S. Nishida, K. Kawamura, K. Eda

  Dec. 2010, Tetrahedron Lett., 51・51・6734-6736, English

  [Refereed]

  Scientific journal


• Facile and highly enantioselective synthesis of (+)- and (-)-fluvastatin and their analogues.

  James T Zacharia, Takanori Tanaka, Masahiko Hayashi

  Nov. 2010, The Journal of organic chemistry, 75(22) (22), 7514 - 8, English, International magazine

  [Refereed]

  Scientific journal


• Dehydrogenation of 1,2,3,4-Tetrahydroquinoline and Its Related Compounds: Comparison of Pd/C―Ethylene System and Activated Carbon―O2 System

  T. Tanaka, K. Okunaga, HAYASHI Masahiko

  Sep. 2010, Tetrahedron Lett., 51・35・4633-4635, English

  [Refereed]

  Scientific journal


• Effect of ortho-substituents on the stereochemistry of 2-(o-substituted phenyl)-1H-imidazoline―palladium complexes

  Z. B. Gan, K. Kawamura, K. Eda, M. Hayashi

  Aug. 2010, Journal of Organometallic Chemistry, 695・17・2022-2029, English

  [Refereed]

  Scientific journal


• Biota uptake of pesticides by selected plant species; the case study of Kilombero sugarcane plantations in Morogoro Region, Tanzania

  J. T. Zacharia, M. A. Kishimba, HAYASHI Masahiko

  May 2010, Pest. Biochem. Physiol., 97・1・71-75, English

  [Refereed]

  Scientific journal


• Titanium Tetraisopropoxide Promoted Reactions for the Synthesis of Substituted Coumarins

  T. Tanaka, K. Yamashita, HAYASHI Masahiko

  Jan. 2010, Heterocycles, 80・1・631-636, English

  [Refereed]

  Scientific journal


• Copper(I)—2-(2'-Pyridyl)benzimidazole Catalyzed N-Arylation of Indoles

  S. Haneda, Y. Adachi, HAYASHI Masahiko

  Dec. 2009, Tetrahedron, 65・50・10459-10462, English

  [Refereed]

  Scientific journal


• Synthesis of heteroaromatic compounds by oxidative aromatization using an activated carbon/molecular oxygen system.

  Yuka Kawashita, Masahiko Hayashi

  Aug. 2009, Molecules (Basel, Switzerland), 14(8) (8), 3073 - 93, English, International magazine

  [Refereed]

  Scientific journal


• Asymmetric desymmetrization of 4,5-epoxycyclohex-1-ene by enantioselective allylic oxidation.

  Qitao Tan, Masahiko Hayashi

  Aug. 2009, Organic letters, 11(15) (15), 3314 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Mechanistic Study of Oxidative Aromatization Using Activated Carbon—Molecular Oxygen System in the Synthesis of 2-Arylbenzazoles: Focus on the Role of Activated Carbon

  Y. Kawashita, J. Yanagi, T. Fujii, HAYASHI Masahiko

  Apr. 2009, Bull. Chem. Soc. Jpn., 82・4・482-488, English

  [Refereed]

  Scientific journal


• 活性炭—酸素系による酸化反応

  HAYASHI Masahiko, 川下 由加

  2009, 「触媒」，持続可能社会実現のための触媒および触媒関連技術特集（触媒学会）, 518-523, Japanese

  [Refereed]

  Scientific journal


• 活性炭が酸化反応を促進する！

  HAYASHI Masahiko, 川下 由加

  2009, 「現代化学」（東京化学同人）, 34-38, Japanese

  [Refereed]

  Scientific journal


• Convenient Synthesis of Linear-extended Bipyridines Involving a Central Phenyl Linking Group

  Z. B. Gan, A. Okui, Y. Kawashita, HAYASHI Masahiko

  Dec. 2008, Chemistry Letters, 37・12・1302-1303, English

  [Refereed]

  Scientific journal


• Catalytic Enantioselective Reformatsky Reaction of Alkyl Iodoacetate with Aldehydes Catalyzed by Chiral Schiff Base

  T. Tanaka, HAYASHI Masahiko

  Dec. 2008, Chemistry Letters, 37・12・1298-1299, English

  [Refereed]

  Scientific journal


• Efficient synthesis of rare sugar D-allal via reversal of diastereoselection in the reduction of protected 1,5-anhydrohex-1-en-3-uloses: protecting group dependence of the stereoselection.

  Takashi Fujiwara, Masahiko Hayashi

  Nov. 2008, The Journal of organic chemistry, 73(22) (22), 9161 - 3, English, International magazine

  [Refereed]

  Scientific journal


• Novel N,N-Bidentate Ligands for Enantioselective Copper(I)-Catalyzed Allylic Oxidation of Cyclic Olefins

  Q. Tan, HAYASHI Masahiko

  Nov. 2008, Advanced Synthesis & Catalysis, 350・16・2639-2644, English

  [Refereed]

  Scientific journal


• New Approach for Complete Reversal of Enantioselectivity Using a Single Chiral Source

  T. Tanaka, HAYASHI Masahiko

  Nov. 2008, Synthesis, 21・3361-3376, English

  [Refereed]

  Scientific journal


• Oxidative Conversion of Functionalized 3,4-Dihydropyrimidin-2(1H)-ones to the Corresponding Pyrimidin-2(1H)- ones using Activated Carbon—molecular Oxygen System

  K. Okunaga, Y. Nomura, K. Kawamura, N. Nakamichi, K. Eda, M. Hayashi

  Sep. 2008, Heterocycles, Vol76, pp715-726, English

  [Refereed]

  Scientific journal


• Chiral Schiff bases as highly active and enantioselective catalysts in catalytic addition of dialkylzinc to aldehydes.

  Takanori Tanaka, Yuki Sano, Masahiko Hayashi

  Sep. 2008, Chemistry, an Asian journal, 3(8-9) (8-9), 1465 - 71, English, International magazine

  [Refereed]

  Scientific journal


• Novel N,N,P-tridentate ligands for the highly enantioselective copper-catalyzed 1,4-addition of dialkylzincs to enones.

  Kenjiro Kawamura, Hitomi Fukuzawa, Masahiko Hayashi

  Aug. 2008, Organic letters, 10(16) (16), 3509 - 12, English, International magazine

  [Refereed]

  Scientific journal


• 2-Phenylimidazole--PdCl2 and 2-Phenylimidazoline--PdCl2 Complexes: Single Crystal and Powder X-ray Diffractometry, 1H NMR Spectra, and Comparison of Catalytic Activities in Coupling Reactions

  K. Kawamura, S. Haneda, Z. Gan, K. Eda, M. Hayashi

  Jul. 2008, Organometallics, Vol27, pp3748-3752, English

  [Refereed]

  Scientific journal


• Versatile and Mild Synthesis of Di- and Trisaccharidic 2,3-Enopyranosyl Cyanides by Cyanation of Per-O-acetylglycals with Trimethylsilyl Cyanide Catalyzed by Palladium(II) Acetate

  X. Xu, Q. Tan, HAYASHI Masahiko

  Mar. 2008, Synthesis, 5・770-776, English

  [Refereed]

  Scientific journal


• Oxidation using activated carbon and molecular oxygen system.

  Masahiko Hayashi

  2008, Chemical record (New York, N.Y.), 8(4) (4), 252 - 67, English, International magazine

  [Refereed]

  Scientific journal


• Fabrications of some kinds of 2D frameworks consisting of nanosized polyoxomolybdate anion [Mo36O112(H2O)16]8- via condensation processes

  K. Eda, Y. Iriki, K. Kawamura, T. Ikuki, M. Hayashi

  Dec. 2007, Journal of Solid State Chemistry, Vol180, pp3588-3593, English

  [Refereed]

  Scientific journal


• Oxidation of secondary benzylic alcohols to ketones by activated carbon-molecular oxygen system

  Yuki Sano, Takanori Tanaka, Masahiko Hayashi

  Dec. 2007, CHEMISTRY LETTERS, 36(12) (12), 1414 - 1415, English

  [Refereed]

  Scientific journal


• Ligand effects of 2-(2-pyridyl)benzazole-Pd complexes on the X-ray crystallographic structures, H-1 NMR spectra, and catalytic activities in Mizoroki-Heck reactions

  Satoshi Haneda, Zhibin Gan, Kazuo Eda, Masahiko Hayashi

  Dec. 2007, ORGANOMETALLICS, 26(26) (26), 6551 - 6555, English

  [Refereed]

  Scientific journal


• Imidazole and imidazoline derivatives as N-donor ligands for palladium-catalyzed Mizoroki-Heck reaction

  Satoshi Haneda, Chigusa Ueba, Kazuo Eda, Masahiko Hayashi

  Apr. 2007, ADVANCED SYNTHESIS & CATALYSIS, 349(6) (6), 833 - 835, English

  [Refereed]

  Scientific journal


• An efficient synthesis of 2-arylimidazoles by oxidation of 2-arylimidazolines using activated carbon-02 system and its application to palladium-catalyzed Mizoroki-Heck reaction

  Satoshi Haneda, Ayaka Okui, Chigusa Ueba, Masahiko Hayashi

  Mar. 2007, TETRAHEDRON, 63(11) (11), 2414 - 2417, English

  [Refereed]

  Scientific journal


• Tris(2,4,6-trimethoxyphenyl)phosphine: Base catalyst in the transformation of alpha,beta unsaturated aldehydes to saturated carboxylic-acid derivatives

  Masahiko Hayashi, Hirotoshi Kawabata, Kazuya Yoshimoto, Takanori Tanaka

  Feb. 2007, PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 182(2) (2), 433 - 445, English

  [Refereed]

  Scientific journal


• 同一の不斉源から両鏡像体を高光学純度で得る手法：触媒的不斉炭素―炭素結合形成反応を中心に

  田中 孝徳, HAYASHI Masahiko

  2007, 有機合成化学協会誌, 65・969-976, Japanese

  [Refereed]

  Scientific journal


• Nitroaldol reaction catalyzed by tris(2,4,6-trimethoxyphenyl) phosphine (TTMPP)

  N. Hirata, M. Hayashi

  2007, SYNTHETIC COMMUNICATIONS, 37(10) (10), 1653 - 1657, English

  [Refereed]

  Scientific journal


• Efficient synthesis of substituted indoles and benzazoles by oxidative aromatization using activated carbon-molecular oxygen system

  Yukiko Nomura, Yuka Kawashita, Masahiko Hayashi

  2007, HETEROCYCLES, 74, 629 - 635, English

  [Refereed]

  Scientific journal


• Complete reversal of enantioselection using oxazoline-containing Schiff base ligands derived from L-serine in enantioselective addition of diketene to aldehydes

  Changhu Chu, Koji Morishita, Takanori Tanaka, Masahiko Hayashi

  Oct. 2006, TETRAHEDRON-ASYMMETRY, 17(18) (18), 2672 - 2677, English

  [Refereed]

  Scientific journal


• New chiral Schiff base as a tridentate ligand for catalytic enantioselective addition of diethylzinc to aldehydes.

  Takanori Tanaka, Yorinobu Yasuda, Masahiko Hayashi

  We have developed new chiral Schiff base catalysts for the enantioselective addition of diethylzinc reagents to aldehydes. The reaction of benzaldehyde with diethylzinc in the presence of 1 mol % of the chiral Schiff base catalyst proceeded to afford 1-phenyl-1-propanol in 96% enantiomeric excess (ee).

  Sep. 2006, The Journal of organic chemistry, 71(18) (18), 7091 - 3, English, International magazine

  [Refereed]

  Scientific journal


• Oxidative aromatization using molecular oxygen promoted by activated carbon

  Masahiko Hayashi, Yuka Kawashita

  Aug. 2006, LETTERS IN ORGANIC CHEMISTRY, 3(8) (8), 571 - 578, English

  [Refereed]

  Scientific journal


• A Simple Synthesis of 2-Arylbenzothiazoles and its Application to Palladium-catalyzed Mizoroki-Heck Reaction

  Kawashita Yuka, Ueba Chigusa, Hayashi Masahiko

  May 2006, Tetrahedron Lett., Vol 47. No. 25, pp. 4231-4233, English

  [Refereed]

  Scientific journal


• Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)(4)-catalyzed Knoevenagel reactions

  K Yamashita, T Tanaka, M Hayashi

  Aug. 2005, TETRAHEDRON, 61(33) (33), 7981 - 7985, English

  [Refereed]

  Scientific journal


• Nitrobenzene as hydrogen acceptor in Pd/C-catalyzed hydrogen transfer reaction

  T Tanaka, H Kawabata, M Hayashi

  Jul. 2005, TETRAHEDRON LETTERS, 46(30) (30), 4989 - 4991, English

  [Refereed]

  Scientific journal


• Novel Knoevenagel-type reaction via titanium enolate derived from Ti(O-i-Pr)(4) and diketene

  M Hayashi, N Nakamura, K Yamashita

  Aug. 2004, TETRAHEDRON, 60(32) (32), 6777 - 6783, English

  [Refereed]

  Scientific journal


• Benzylic oxygenation of alkylarenes with molecular oxygen in the presence of activated carbon

  H Kawabata, M Hayashi

  Jul. 2004, TETRAHEDRON LETTERS, 45(28) (28), 5457 - 5459, English

  [Refereed]

  Scientific journal


• Activated carbon-promoted oxidative aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines using molecular oxygen

  N Nakamichi, Y Kawashita, M Hayashi

  May 2004, SYNTHESIS-STUTTGART, 1015-1020(7) (7), 1015 - 1020, English

  [Refereed]

  Scientific journal


• Synthesis of versatile chiral N,P ligands derived from pyridine and quinoline.

  William J Drury 3rd, Nicole Zimmermann, Martine Keenan, Masahiko Hayashi, Stefan Kaiser, Richard Goddard, Andreas Pfaltz

  Jan. 2004, Angewandte Chemie (International ed. in English), 43(1) (1), 70 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Superconductivity on a Moebius strip: numerical studies on order parameter and quasiparticles.

  HAYASHI Masahiko, EBISAWA, H, KUBOKI Kazuhiro

  2004, to appear in Phys. Rev.B, 未記入, English

  [Refereed]

  Scientific journal


• Oxidative aromatization of 9,10-dihydroanthracenes using molecular oxygen promoted by activated carbon.

  Natsuki Nakamichi, Hirotoshi Kawabata, Masahiko Hayashi

  Oct. 2003, The Journal of organic chemistry, 68(21) (21), 8272 - 3, English, International magazine

  Scientific journal


• Direct and practical synthesis of 2-arylbenzoxazoles promoted by activated carbon.

  Yuka Kawashita, Natsuki Nakamichi, Hirotoshi Kawabata, Masahiko Hayashi

  Oct. 2003, Organic letters, 5(20) (20), 3713 - 5, English, International magazine

  Scientific journal


• Stereoselective C-glycosidation of unprotected D-glycals with trimethylsilyl cyanide.

  Masahiko Hayashi, Hirotoshi Kawabata, Shu-Zo Nakayama

  Jan. 2003, Chirality, 15(1) (1), 10 - 6, English, International magazine

  Scientific journal


• Oxidative aromatization of 1,3,5-trisubstituted pyrazolines and Hantzsch 1,4-dihydropyridines by Pd/C in acetic acid.

  Natsuki Nakamichi, Yuka Kawashita, Masahiko Hayashi

  Oct. 2002, Organic letters, 4(22) (22), 3955 - 7, English, International magazine

  [Refereed]

  Scientific journal


• Lewis base-catalyzed transformation of alpha,beta-unsaturated aldehydes to saturated carboxylic acids, esters and amides

  H Kawabata, M Hayashi

  Aug. 2002, TETRAHEDRON LETTERS, 43(32) (32), 5645 - 5647, English

  [Refereed]

  Scientific journal


• Tris(2,4,6-trimethoxyphenyl)phosphine (TTMPP): A novel catalyst for selective deacetylation

  K Yoshimoto, H Kawabata, N Nakamichi, M Hayashi

  Sep. 2001, CHEMISTRY LETTERS, (9) (9), 934 - 935, English

  [Refereed]

  Scientific journal


• C-glycosidation of unprotected D-glycals with trimethylsilyl cyanide

  M Hayashi, H Kawabata, O Arikita

  Feb. 1999, TETRAHEDRON LETTERS, 40(9) (9), 1729 - 1730, English

  [Refereed]

  Scientific journal


• Asymmetric Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Shiff-Base-Titanium Alkoxide Complexes.

  HAYASHI Masahiko, OGUNI Nobuki

  The enantioselective addition of trimethylsilyl cyanide to a variety of aldehydes proceeded by the aid of a catalyst prepared in situ from titanium tetraisopropoxide [Ti(O-i-Pr)₄] and chiral Schiff bases and gave the corresponding cyanohydrins in high optical yield (up to 96% e.e.). A remarkable rate enhancement was brought about by the aid of the Schiff base to the titanium alkoxide mediated silylcyanation of aldehydes. This catalyst also promoted the highly enantioselective reaction of diketene with aldehydes to give the optically active 5-hydroxy-3-oxoesters, which can be easily converted to 6-substituted-4-hydroxy lactones. These lactones are known to be a very important component of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase such as compacitn and mevinolin. The chemical structure of chiral Schiff base-titanium alkoxide complexes is discussed based on their ¹³C NMR spectra, field desorption (FD) mass spectra, and molecular weights.

  The Society of Synthetic Organic Chemistry, Japan, 1994, J. Synth. Org. Chem. Jpn., 52(6) (6), 488 - 497, Japanese

• New approach for complete reversal of enantioselection using Schiff base ligand

  Takanori Tanaka, Masahiko Hayashi

  Oct. 2007, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 65(10) (10), 969 - 976, Japanese

  Book review


• Environmentally benign oxidation of alcohols using transition metal catalysts

  M Hayashi, H Kawabata

  Feb. 2002, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 60(2) (2), 137 - 144, Japanese

  Book review


• Asymmetric Carbon Carbon Bond Forming Reactions Catalyzed by Chiral Titanium Complexes-An Efficient Synthesis of Optically Active Secondary Alcohols-

  HAYASHI Masahiko

  日本化学会, 01 Feb. 1996, 化学と工業 = Chemistry and chemical industry, 49(2) (2), 147 - 150, Japanese

• 活性炭ハンドブック

  HAYASHI Masahiko, 川下 由加

  Single translation, 丸善, 2011, Japanese

  Scholarly book


• 使える！有機合成反応

  HAYASHI Masahiko

  Others, 化学同人, 2010, Japanese

  Scholarly book


• 第5版実験化学講座(pp.561（36））

  林 昌彦

  Joint work, 丸善, Mar. 2004, Japanese

  Scholarly book


• 有機合成のための触媒反応(pp.2007（4））

  林 昌彦

  Joint work, 東京化学同人, 2004, Japanese

  Scholarly book

• Pd/C-エチレン系を用いたフェノール誘導体およびアニリン誘導体の合成

  三木啓吾, 松原亮介, 林昌彦

  第50回反応と合成の進歩シンポジウム, Oct. 2024, Japanese, 日本薬学会化学系薬学部会, 神戸, Domestic conference

  Poster presentation


• Pd/Cｰエチレン系を用いた2-ピリジルフェノールと2-ピリジルアニリンの合成

  三木啓吾, 松原亮介, 林昌彦

  第53回複素環化学討論会, Oct. 2024, Japanese, 第53回複素環科学討論会, 山口, Domestic conference

  Oral presentation


• ベンズイミダゾリウム触媒を用いて CO2 をギ酸に還元する研究

  許 佳生, 謝 衛斌, 原田 竜大, 藪田 達志, 林 昌彦, 松原 亮介

  第40回有機合成化学セミナー, Sep. 2024, Japanese, 有機合成化学協会関東支部, 新潟, Domestic conference

  Poster presentation


• ヒドリド性C-H結合を持つ有機還元剤の環境調和的な光触媒化

  原田竜大, 謝衛斌, 薮田達志, 許佳生, 林昌彦, 松原亮介

  第40回有機合成化学セミナー, Sep. 2024, Japanese, 有機合成化学協会関東支部, 新潟, Domestic conference

  Poster presentation


• ボラインデンの合成と物性評価

  村上賢, 松原亮介, 林昌彦

  第70回有機金属化学討論会, Sep. 2024, Japanese, 近畿化学協会有機金属部会, 大阪公立大学, Domestic conference

  Oral presentation


• 光増感剤および遷移金属を用いないベンズイミダゾリン型有機ヒドリドの光再生反応

  原田竜大, 謝衛斌, 薮田達志, 許佳生, 林昌彦, 松原亮介

  第44回有機合成若手セミナー「明日の有機合成を担う人のために」, Aug. 2024, Japanese, 有機合成化学協会関西支部, 大阪, Domestic conference

  Poster presentation


• アニオン性置換基を有するカルバゾール光増感剤の合成、物性評価、光反応への応用

  宮本 陸人, 薮田 達志, 林昌彦, 松原 亮介

  日本化学会第103春季年会, Mar. 2023, 日本化学会, Japan, Domestic conference


• 炭酸セシウムにより活性化されたカルバゾール光増感剤を用いたアルキルアリールエーテルのC–O結合の光還元的切断反応

  薮田 達志, 林昌彦, 松原 亮介

  日本化学会第103春季年会, Mar. 2023, Japanese, 日本化学会, 東京理科大学, Domestic conference

  Oral presentation


• Pd/C-エチレン系を用いた置換インドールの新規合成法

  匡 陽金, 前田 勝海, 松原 亮介, 林 昌彦

  Sep. 2022, Japan, Domestic conference


• ルテニウム触媒を用いる三重結合のジホウ素化反応

  村上賢, 松原亮介, 林 昌彦

  日本化学会第101春季年会, Mar. 2021, Japanese


• ニトリル配位子を有するCp*Ru錯体の合成とそれを用いた触媒反応

  村上賢, 松原亮介, 林 昌彦

  日本化学会第100春季年会, Mar. 2020, Japanese


• 触媒的不斉アミノヒドロキシル化反応を用いたアミノ糖合成

  福原 一平, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  神戸大学 研究基盤センター 若手フロンティア研究会2018, Dec. 2018, Japanese, 神戸大学百年記念館, Domestic conference

  Poster presentation


• 効率的なラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, Md IdrosUbaidah Afiq, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会 第98春季年会 (2018), Mar. 2018, Japanese, 日本大学理工学部, Domestic conference

  Poster presentation


• フロキサンからα-ケトエステルへの光化学的変換

  江口 修平, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会 第98春季年会 (2018), Mar. 2018, Japanese, 日本大学理工学部, Domestic conference

  Oral presentation


• N-アリールカルバゾールを基本骨格とした新規固体蛍光物質の合成

  飼馬 知明, 薮田 達志, UCHINO TAKASHI, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会 第98春季年会 (2018), Mar. 2018, Japanese, 日本大学理工学部, Domestic conference

  Poster presentation


• 効率的な炭素ラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, Afiq Md Idros, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  第34回有機合成化学セミナー, Sep. 2017, Japanese, 金沢市文化ホール, Domestic conference

  Poster presentation


• Development of Novel Photo-labile Protecting Group for Cyano Grou

  ○Afiq Md Idros, Huiying Ma, Masahiko Hayashi, Ryosuke Matsubara

  第37回有機合成若手セミナー「明日の有機合成を担う人のために」, Aug. 2017, English, 同志社大学（室町キャンパス）, Domestic conference

  Poster presentation


• 新規フロキサン誘導体合成法の開発と光応答性一酸化窒素ドナーへの応用

  安藤 祥大, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  第111回有機合成シンポジウム2017年【春】, Jun. 2017, Japanese, 岡山大学（島津キャンパス）, Domestic conference

  Oral presentation


• 効率的な炭素ラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  第111回有機合成シンポジウム2017年【春】, Jun. 2017, Japanese, 岡山大学（島津キャンパス）, Domestic conference

  Poster presentation


• Dehydrogenative Formation of Resorcinol Derivatives using Pd/C-Ethylene Catalytic System

  Masahiko HAYASHI

  The International Symposium on Pure & Applied Chemistry (ISPAC) 2017, Jun. 2017, English, Ho Chi Minh City, Vietnam, International conference

  [Invited]

  Invited oral presentation


• 直接的シアノ化による効率的なシアノフロキサン誘導体合成法の開発

  安藤 祥大, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• 効率的な炭素ラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• 凝集誘起発光を有するカルバゾール誘導体の合成及び光物性研究

  飼馬 知明, 薮田 達志, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• 強力な脱離基を有するフロキサンの合成

  葛城 裕規, 安藤 祥大, 江口 修平, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• アルキニルフロキサン合成法の開発と誘導体化の検討

  江口 修平, 安藤 祥大, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• Pd/C-エチレン系を用いたレゾルシノール誘導体の合成

  下元 佑也, Yussif El-Deeb Ibrahim, 船越 達哉, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  日本化学会第97春季年会（2017）, Mar. 2017, Japanese, 慶應義塾大学(横浜), Domestic conference

  Oral presentation


• 効率的な炭素ラジカルの生成を目指した 有機分子光触媒の開発

  薮田 達志, 島田 聡之, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  若手フロンティア研究会2016, Dec. 2016, Japanese, 神戸大学研究基盤センター, Domestic conference

  Poster presentation


• 効率的な炭素ラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, 島田 聡之, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  第9回有機触媒シンポジウム 有機触媒研究会、研究開発専門委員会「有機分子触媒による高度分子変換技術」, Dec. 2016, Japanese, 名古屋大学, Domestic conference

  Poster presentation


• 効率的なシアノフロキサン合成法の開発

  安藤 祥大, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  若手フロンティア研究会2016, Dec. 2016, Japanese, 神戸大学研究基盤センター, Domestic conference

  Poster presentation


• 光応答性一酸化窒素ドナーの開発

  高沢 紗緒里, MATSUBARA RYOSUKE, 安藤 祥大, HAYASHI MASAHIKO

  若手フロンティア研究会2016, Dec. 2016, Japanese, 神戸大学研究基盤センター, Domestic conference

  Poster presentation


• アルキニル基を有するフロキサン合成法 の開発とその応用

  江口 修平, 安藤 祥大, HAYASHI MASAHIKO, MATSUBARA RYOSUKE

  若手フロンティア研究会2016, Dec. 2016, Japanese, 神戸大学研究基盤センター, Domestic conference

  Poster presentation


• 効率的な炭素ラジカルの生成を目指した有機分子触媒の開発

  薮田 達志, MATSUBARA RYOSUKE, HAYASHI MASAHIKO, KOBORI YASUHIRO

  第6回CSJ化学フェスタ2016, Nov. 2016, Japanese, タワーホール船堀, Domestic conference

  Poster presentation


• ハロフロキサンの新規合成法の開発と光応答性一酸化窒素ドナーへの応用

  安藤 祥大, MATSUBARA RYOSUKE, 髙沢 紗緒里, HAYASHI MASAHIKO

  第6回CSJ化学フェスタ2016, Nov. 2016, Japanese, タワーホール船堀, Domestic conference

  Poster presentation


• アルキニル基を有するフロキサン合成法の開発とその応用

  江口 修平, MATSUBARA RYOSUKE, 安藤 祥大, HAYASHI MASAHIKO

  第6回CSJ化学フェスタ2016, Nov. 2016, Japanese, タワーホール船堀, Domestic conference

  Poster presentation


• 効率的な炭素ラジカルの生成を目指した有機分子光触媒の開発

  薮田 達志, 島田 聡之, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  第7回サイエンスフロンティア研究発表会, Oct. 2016, Japanese, 神戸大学, Domestic conference

  Poster presentation


• アルキニル基を有するフロキサン合成法の開発とその応用

  江口 修平, 安藤 祥大, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  第7回サイエンスフロンティア研究発表会, Oct. 2016, Japanese, 神戸大学, Domestic conference

  Poster presentation


• 触媒的不斉ジヒドロキシル化反応を用いた希少糖合成

  波戸 陽一, 道上 恭佑, 永橋 孝明, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  第46回 複 素環 化学 討 論会, Sep. 2016, Japanese, 金沢歌劇座, Domestic conference

  Oral presentation


• Dehydrogenative Formation of Resorcinol Derivatives Using Pd/C―Ethylene System

  El-Deeb Ibrahim, 舟越 達哉, 田 苗苗, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  第63回有機金属化学討論会, Sep. 2016, English, 東京(早稲田大学), Domestic conference

  Poster presentation


• 触媒的不斉ジヒドロキシ化反応を用いた希少糖合成

  波戸 陽一, 永橋 孝明, 道上 恭佑, 松原 亮介, HAYASHI MASAHIKO

  日本化学会第96春季年会, Mar. 2016, Japanese, 日本化学会, Domestic conference

  Oral presentation


• 効率的な炭素ラジカルの生成を目指した有機分子触媒の開発

  薮田 達志, MATSUBARA RYOSUKE, 島田 聡之, HAYASHI MASAHIKO, KOBORI YASUHIRO

  日本化学会 第96春季年会 (2016), Mar. 2016, Japanese, 同志社大学 京田辺キャンパス, Domestic conference

  Oral presentation


• 光応答性一酸化窒素ドナーの開発

  高沢 紗緒里, MATSUBARA RYOSUKE, 安藤 祥大, HAYASHI MASAHIKO

  日本化学会 第96春季年会 (2016), Mar. 2016, Japanese, 同志社大学 京田辺キャンパス, Domestic conference

  Oral presentation


• ハロフロキサンの新規合成法の開発と一酸化窒素ドナーへの応用

  安藤 祥大, 髙沢 紗緒里, 松原 亮介, 林 昌彦

  日本薬学会第１３６年会, Mar. 2016, Japanese, 日本薬学会, 横浜, Domestic conference

  Oral presentation


• シアノ基の光感受性保護基の開発

  馬 慧穎, MATSUBARA RYOSUKE, HAYASHI MASAHIKO

  日本化学会 第96春季年会 (2016), Mar. 2016, Japanese, 同志社大学 京田辺キャンパス, Domestic conference

  Oral presentation


• アルキニル基を含んだフロキサン誘導体の合成

  江口 修平, MATSUBARA RYOSUKE, 安藤 祥大, HAYASHI MASAHIKO

  日本化学会 第96春季年会 (2016), Mar. 2016, Japanese, 同志社大学 京田辺キャンパス, Domestic conference

  Oral presentation


• Synthesis of 2,3-Unsaturated Sugars Using Aluminium Aryloxide

  Afiq Md Idros, Yoichi Namito, Ryosuke Matsubara, Masahiko Hayashi

  日本化学会第96春季年会, Mar. 2016, English, 日本化学会, Domestic conference

  Oral presentation


• Practical synthesis of resorcinol derivatives using Pd C ethylene system

  EL-DEEB Ibrahim, FUNAKOSHI Tatsuya, DEN Tian, MATSUBARA Ryosuke, HAYASHI Masahiko

  日本化学会第96春季年会, Mar. 2016, English, 日本化学会, Domestic conference

  Oral presentation


• 触媒的不斉ジヒドロキシ化を用いた希少糖合成

  波戸 陽一, 永橋 孝明, 道上 恭佑, 松原 亮介, 林 昌彦

  若手フロンティア研究会２０１５, Dec. 2015, Japanese, 神戸大学研究基盤センター, 神戸, Domestic conference

  Poster presentation


• フラボノイド類の配糖化

  松田 奈央美, Ibrahim Yussif El Deeb, 松原 亮介, 林 昌彦

  若手フロンティア研究会２０１５, Dec. 2015, Japanese, 神戸大学研究基盤センター, 神戸, Domestic conference

  Poster presentation


• Practical synthesis of resorcinol derivatives using Pd C-ethylene system

  Ibrahim Yussif El Deeb, Tatsuya Funakoshi, Tian Den, Ryosuke Matsubara, Masahiko Hayashi

  若手フロンティア研究会２０１５, Dec. 2015, English, 神戸大学研究基盤センター, 神戸, Domestic conference

  Poster presentation


• D-アロースによる配糖化

  池本 葵, 松原 亮介, 林 昌彦

  若手フロンティア研究会２０１５, Dec. 2015, Japanese, 神戸大学研究基盤センター, 神戸, Domestic conference

  Poster presentation


• The Development of a Direct Deoxygenation of Alcohols

  Ryosuke Matsubara, Toshiyuki Shimada, Yong-Soon Shin, Masahiko Hayashi

  第2回国際会議(兼)第7回有機触媒シンポジウム, Nov. 2014, English, 東京大学, International conference

  Poster presentation


• Enantioselective Allylic Oxidation and Its Application for the Synthesis of (-)-Oseltamivir Phosphate and Oxylipin

  Masahiko Hayashi

  18th Malaysian International Chemical Congress(18MICC)2014, Nov. 2014, English, Kuala Lumpur, Malaysia, International conference

  [Invited]

  Invited oral presentation


• Catalytic Asymmetric Allylic Oxidation and Its Application for the Synthesis of Some Bioactive Compounds

  Masahiko Hayashi

  Vietnam Malaysia International Chemical Congress(VMICC)2014, Nov. 2014, English, Hanoi, Vietnam, International conference

  [Invited]

  Invited oral presentation


• Design of Photo-controllable Cyclic Peptides

  Shinji Kawabata, Yasuhiro Ebisu, Yuta Saeki, Masahiko Hayashi, Atsuo Tamura

  第51回日本生物物理学会年会, Oct. 2013, English, 京都, Domestic conference

  Poster presentation


• 銅－シッフ塩基配位子を用いたジアルキル亜鉛のエノン類への高エナンチオ選択的 1,4-付加反応

  蛭子 靖弘, 川村 健二郎, HAYASHI Masahiko

  日本化学会第92春季年会, Mar. 2012, Japanese, 日本化学会, 神奈川, Domestic conference

  Oral presentation


• 光延反応を利用した不飽和グリコシドの合成法の開発

  道上恭佑, HAYASHI Masahiko

  日本化学会第92春季年会, Mar. 2012, Japanese, 日本化学会, 神奈川, Domestic conference

  Oral presentation


• グリコシドおよびその誘導体の効率的合成法の開発

  足立 美峰, 道上 恭佑, 内田 怜志, HAYASHI Masahiko

  日本化学会第92春季年会, Mar. 2012, Japanese, 日本化学会, 神奈川, Domestic conference

  Oral presentation


• 活性炭を用いる酸化反応

  HAYASHI Masahiko

  活性炭研究会, Nov. 2011, Japanese, 大阪, Domestic conference

  Invited oral presentation


• Novel Chiral N,N,P―Tridentate Ligands for Highly Enantioselective 1,4-Addition to Enones by Dialkylzincs

  Y. Ebisu, K. Kawamura, HAYASHI Masahiko

  2011 International Symposium on. Organometallic Chemistry, Nov. 2011, English, 大阪, International conference

  Poster presentation


• Novel Chiral N,N,P―Tridentate Ligands for Highly Enantioselective 1,4-Addition to Enones by Dialkylzincs

  Y. Ebisu, K. Kawamura, HAYASHI Masahiko

  1st International Symposium on Molecular Activation, Nov. 2011, English, Hyogo, Japan, International conference

  Poster presentation


• Novel Chiral N,N,P―Tridentate Ligands for Highly Enantioselective 1,4-Addition to Enones by Dialkylzincs

  蛭子 靖弘, 川村 健二郎, HAYASHI Masahiko

  第58回有機金属化学討論会, Sep. 2011, Japanese, 名古屋, Domestic conference

  Poster presentation


• Highly Enantioselective 1,4-Addition of Dialkylzincs to Enones Using Novel N,N,P-Tridentate Ligands

  K. Kawamura, H. Fukuzawa, HAYASHI Masahiko

  The 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem 2010), Dec. 2010, English, Hawaii, USA, International conference

  Poster presentation


• Oxidative Aromatization Using Activated Carbon Oxidation System

  K. Michigami, HAYASHI Masahiko

  The 6th International Symposium on Integrated Synthesis (ISIS-6), Oct. 2010, English, Kobe, Japan, International conference

  Poster presentation


• Effect of ortho-substitutents on the stereochemistry of 2-(o-substituted phenyl)-1H-imidazoline-palladium complexes

  川村 健二郎, 甘 智斌, 道上 恭佑, 田中 孝徳, EDA KAZUO, HAYASHI Masahiko

  第57回有機金属化学討論会, Sep. 2010, Japanese, 近畿化学協会有機金属化学討論会, 八王子, Domestic conference

  Poster presentation


• 希少糖の効率的かつ効果的合成戦略

  HAYASHI Masahiko

  香川大学希少糖セミナー, Jul. 2010, Japanese, Domestic conference

  Invited oral presentation


• Catalytic Asymmetric Reactions Using Chiral Schiff Base-Metal Complexes

  HAYASHI Masahiko

  Catalytic Asymmetric Synthesis 2010, May 2010, English, Beijing, China, International conference

  [Invited]

  Invited oral presentation


• Catalytic Asymmetric Reactions Using Chiral Schiff Base―metal Complex

  HAYASHI Masahiko

  Catalytic Asymmetric Synthesis 2010, May 2010, English, Beijing, China, International conference

  [Invited]

  Invited oral presentation


• 銅（I)－2－（2’－ピリジル）ベンズイミダゾール触媒によるインドール類のN-アリール化反応

  足立 祐輔, 羽根田 聡, HAYASHI Masahiko

  日本化学会第91春季年会, Mar. 2010, Japanese, 日本化学会, 大阪, Domestic conference

  Oral presentation


• 活性炭-酸素系によるチオールからジスルフィドへの酸化反応

  奥長 健一, 川村 健二郎, Eda Kazuo, HAYASHI Masahiko

  日本化学会第90春季年会, Mar. 2010, Japanese, 日本化学会, 東大阪市, Domestic conference

  Oral presentation


• タミフル合成中間体の高エナンチオ選択的合成

  田中 孝徳, 譚 啓濤, HAYASHI Masahiko

  日本化学会第90春季年会, Mar. 2010, Japanese, 日本化学会, 大阪, Domestic conference

  Oral presentation


• エナンチオ選択的アリル位酸化による4,5-エポキシシクロヘキサ-1-エンの不斉非対称化

  岩永 和也, 譚 啓濤, HAYASHI Masahiko

  日本化学会第90春季年会, Mar. 2010, Japanese, 日本化学会, 東大阪, Domestic conference

  Oral presentation


• N,N,P型三座配位子を用いたジアルキル亜鉛のエノン類への高エナンチオ選択的 1,4-付加反応

  川村 健二郎, 福澤 比斗実, HAYASHI Masahiko

  日本化学会第90春季年会, Mar. 2010, Japanese, 日本化学会, 東大阪, Domestic conference

  Oral presentation


• (+)および(-)-フルバスタチンとその誘導体の効率的かつ高エナンチオ選択的合成

  J. T. Zacharia, 田中 孝徳, HAYASHI Masahiko

  日本化学会第90春季年会, Mar. 2010, English, 日本化学会, 大阪, Domestic conference

  Oral presentation


• 環境に負荷をかけない有機合成〜酸化反応を中心に〜

  HAYASHI Masahiko

  エコファーマシンポジウム, Feb. 2010, Japanese, 熊本, Domestic conference

  [Invited]

  Invited oral presentation


• Highly Enantioselective 1,4-Addition of Dialkylzincs to Enones Using Novel N,N,P-Tridentate Ligands

  K. Kawamura, H. Fukuzawa, HAYASHI Masahiko

  11th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-11), Nov. 2009, English, Kyoto, Japan, International conference

  Oral presentation


• Synthesis of Rare Sugar D-Allal and Studies of Oligosaccharide Synthesis Containing Rare Sugar D-Allal in Terminal

  藤原 嵩士, HAYASHI Masahiko

  第36回有機反応懇談会, Aug. 2009, Japanese, 兵庫, Domestic conference

  Poster presentation


• Oxidative Conversion of Functionalyzed 3,4-Dihydropyridine-2(1H)-ones to the Corresponding Pyrimidin-2(1H)-ones Using Activated Carbon-Molecular Oxygen System

  奥長 健一, 野村 由紀子, 川村 健二郎, 中道 夏樹, EDA KAZUO, HAYASHI Masahiko

  第36回有機反応懇談会, Aug. 2009, Japanese, 兵庫, Domestic conference

  Poster presentation


• Development of New Catalysts for the Synthesis of Optically and Biologically Active Compounds

  HAYASHI Masahiko

  International Conference on Medicinal Chemistry, 2009: Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, Aug. 2009, English, Bandung, Indonesia, International conference

  Oral presentation


• Copper-Catalyzed N-Arylation of Indoles Using 2-(2'-pyridyl)benzimidazole Ligand

  足立 祐輔, 羽根田 聡, HAYASHI Masahiko

  第36回有機反応懇談会, Aug. 2009, Japanese, 兵庫, Domestic conference

  Poster presentation


• Asymmetric Synthesis in Organic Chemistry

  HAYASHI Masahiko

  INSTITUT TEKNOLOGI BANDUNG，Short Course in Medicinal Chemistry, Aug. 2009, English, Bandung, Indonesia, International conference

  Oral presentation


• Highly Enantioselective 1,4-Addition of Dialkylzincs to Enones Using Novel N,N,P-Tridentate Ligands

  K. Kawamura, H. Fukuzawa, HAYASHI Masahiko

  15th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 15), Jul. 2009, English, Glasgow, UK, International conference

  Oral presentation


• Catalytic Asymmetric Reactions Using Chiral Schiff Base—Metal Complexes

  HAYASHI Masahiko

  International Symposium on Chiral Compounds and Special Polymers, Jul. 2009, English, Harbin, China, International conference

  [Invited]

  Invited oral presentation


• Asymmetric Synthesis in Organic Reactions

  HAYASHI Masahiko

  State Key Laboratory of Fine Chemicals, Jul. 2009, English, Dalian, China, International conference

  [Invited]

  Invited oral presentation


• 新型光学活性シッフ塩基配位子の開発と触媒的不斉合成への適用

  HAYASHI Masahiko

  特定領域研究「炭素資源の高度分子変換」取り纏めシンポジウム, Jun. 2009, Japanese, 京都, Domestic conference

  [Invited]

  Invited oral presentation


• 保護した1-エン-3-ウロースのジアステレオ選択的還元による稀少糖D-アラールの効率的合成

  藤原 嵩士, HAYASHI Masahiko

  日本化学会第89春季年会, Mar. 2009, Japanese, 日本化学, 千葉, Domestic conference

  Oral presentation


• 活性炭―酸素系による酸化反応を利用したピリミジン類の効率的合成

  奥長 健一, 野村 由紀子, HAYASHI Masahiko

  日本化学会第89春季年会, Mar. 2009, Japanese, 日本化学, 千葉, Domestic conference

  Oral presentation


• N,N,P型三座配位子を用いた銅触媒によるジアルキル亜鉛のエノン類への高エナンチオ選択的1,4-付加反応

  川村 健二郎, 福澤 比斗実, HAYASHI Masahiko

  日本化学会第89春季年会, Mar. 2009, Japanese, 日本化学, 千葉, Domestic conference

  Oral presentation


• 触媒的不斉炭素－炭素結合の構築：アルデヒドへのエナンチオ選択的付加反応を中心に

  HAYASHI Masahiko

  山口大学応用分子生命科 学常盤台コロキアム, Dec. 2008, Japanese, 山口, Domestic conference

  Invited oral presentation


• 活性炭―酸素系による第二級ベンジルアルコールの酸化反応

  田中 孝徳, 佐野 友紀, HAYASHI Masahiko

  第41回酸化反応討論会, Nov. 2008, Japanese, 福岡, Domestic conference

  Oral presentation


• 活性炭―酸素系による酸化反応を利用した種々の複素環化合物の効率的合成

  野村 由紀子, 奥長 健一, 川村 健二郎, EDA Kazuo, HAYASHI Masahiko

  第38回複素環化学討論会, Nov. 2008, Japanese, 複素環化学討論会実行委員会, 福山, Domestic conference

  Oral presentation


• 活性炭―酸素系を用いた芳香族複素環化合物の効率的合成

  HAYASHI Masahiko

  ヘテロ原子部会平成20年度第2回懇話会, Sep. 2008, Japanese, ヘテロ原子部会, 神戸, Domestic conference

  Oral presentation


• Enantioselective 1,4-Addition of Dialkylzinc to Enones Using Novel N,N,P-tridentate Ligands

  川村 健二郎, 福澤 比斗実, HAYASHI Masahiko

  第55回有機金属化学討論会, Sep. 2008, Japanese, 大阪, Domestic conference

  Poster presentation


• Novel Chiral N,N,P―Tridentate Ligands for Highly Enantioselective Copper-Catalyzed 1,4-Addition of Dialkylzinc to Enones

  川村 健二郎, 福澤 比斗実, HAYASHI Masahiko

  第35回有機反応懇談会, Aug. 2008, English, 有機反応懇談会, 大阪, Domestic conference

  Poster presentation


• Highly Enantioselective 1,4-Addition of Dialkylzinc to Enones Using Novel N,N,P―tridentate Ligands

  川村 健二郎, 福澤 比斗実, HAYASHI Masahiko

  第35回有機反応懇談会, Aug. 2008, English, 有機反応懇談会, 大阪, Domestic conference

  Poster presentation


• Chiral Schiff Bases as Highly Active and Enantioselective Catalysts in Catalytic Addition of Dialkylzincs to Aldehydes

  田中 孝徳, 佐野 友紀, HAYASHI Masahiko

  第35回有機反応懇談会, Aug. 2008, English, 有機反応懇談会, 大阪, International conference

  Poster presentation


• Development of Imidazoline and Imidazole Ligands toward Efficient Cross-Coupling Reactions

  S. Haneda, K. Kawamura, Z. Gan, EDA Kazuo, HAYASHI Masahiko

  23rd International Conference on Organometallic Chemistry (ICOMC2008), Jul. 2008, English, Rennes, France, International conference

  Poster presentation


• New Chiral N,N,P―Tridentate Ligands for Highly Enantioselective Conjugate Addition of Dialkylzinc to Enones

  K. Kawamura, HAYASHI Masahiko

  Third International Conference on Advanced Organic Synthesis Directed toward the Ultimate Efficiency and Practicability, May 2008, English, Ohtsu, Japan, International conference

  Poster presentation


• 溝呂木－Heck反応を指向したイミダゾール、イミダゾリン配位子の創製

  羽根田 聡, 奥井 あやか, EDA Kazuo, HAYASHI Masahiko

  日本化学会第87春季年会, Mar. 2008, Japanese, 日本化学会, 吹田, Domestic conference

  Oral presentation


• トリアミンをリンカーとしたナノサイズ縮合モリブデン酸イオンの2次元フレームワークの構築

  小塚 達也, Eda Kazuo, 入来 雄一, 川村 健二郎, HAYASHI MASAHIKO

  日本化学会第88春季年会, Mar. 2008, Japanese, 日本化学会, 東京都豊島区, Domestic conference

  Oral presentation


• Catalytic Asymmetric Carbon-Carbon Bond Forming Reactions Catalyzed by Chiral Schiff Base-Metal Complexes

  HAYASHI Masahiko

  Japan-Singapore Bilateral Symposium on Catalysis, Jan. 2008, English, Singapore, International conference

  [Invited]

  Invited oral presentation


• New Oxidation Method Using Activated Carbon and Molecular Oxygen

  HAYASHI Masahiko

  International Symposium on Catalysis and Fine Chemicals 2007, Dec. 2007, English, Singapore, International conference

  [Invited]

  Invited oral presentation


• New Palladium―Imidazole and Imidazoline Complexes: Structure and Reactivity in Coupling Reaction

  甘 智斌, 羽根田 聡, EDA Kazuo, HAYASHI Masahiko

  第54回有機金属化学討論会, Oct. 2007, Japanese, 近畿化学協会有機金属化学討論会, 広島, Domestic conference

  Poster presentation


• New Palladium―Imidazole and Imidazoline Complexes: Structure and Reactivity in Coupling Reaction

  Z. B. Gan, S. Haneda, EDA Kazuo, HAYASHI Masahiko

  17th International Symposium on Fine Chemistry and Functional Polymers (FCFP-XVII) & IUPAC 3rd International Symposium on Novel Materials and Synthesis (NMS-III), Oct. 2007, English, Shanghai, China, International conference

  Poster presentation


• Catalytic Asymmetric Carbon―Carbon Bond Forming Reactions Catalyzed Chiral Schiff Based―Metal Complexes

  T. Tanaka, HAYASHI Masahiko

  17th International Symposium on Fine Chemistry and Functional Polymers (FCFP-XVII) & IUPAC 3rd International Symposium on Novel Materials and Synthesis (NMS-III), Oct. 2007, English, Shanghai, China, International conference

  Oral presentation


• Study of Effect on Reactivity of Azole Ligands in Palladium-Catalyzed Mizoroki-Heck Reaction

  S. Haneda, EDA Kazuo, HAYASHI Masahiko

  14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis, Aug. 2007, English, Nara, Japan, International conference

  Poster presentation


• Study of 2-(2'-Pyridyl)benzazoles Ligands Effect Based on X-ray Crystallography, 1H NMR Spectrum Analysis and its Application to Mizoroki-Heck Reaction

  S. Haneda, HAYASHI Masahiko

  Second International Conference on Advanced Organic Synthesis Directed toward the Ultimate Efficiency and Practicability, May 2007, English, Ohtsu, Japan, International conference

  Poster presentation


• Complete Reversal of Enantioselection Using Oxazoline-containing Schiff Base Ligands Derived from L-Serine in Enantioselective Addition of Diketene to Aldehydes

  T. Tanaka, C. H. Chu, HAYASHI Masahiko

  Second International Conference on Advanced Organic Synthesis Directed toward the Ultimate Efficiency and Practicability, May 2007, English, Ohtsu, Japan, International conference

  Poster presentation


• パラジウム触媒を用いた溝呂木Heck 反応におけるアゾール型配位子効果による反応性の考察

  羽根田 聡, 甘 智斌, EDA Kazuo, HAYASHI Masahiko

  日本化学会第87春季年会, Mar. 2007, Japanese, 日本化学会, 吹田, Domestic conference

  Oral presentation


• 新しい光学活性シッフ塩基配位子を用いたジアルキル亜鉛によるアルデヒドの不斉アルキル化反応

  Sano Yuki, Tanaka Takanori, Hayashi Masahiko

  第26回有機合成若手セミナー, Dec. 2006, Japanese, 有機合成化学協会, 大阪, Domestic conference

  Poster presentation


• L-セリン由来の新規なオキサゾリン型シッフ塩基―チタン触媒を用いたジケテンのアルデヒドへの不斉付加反応におけるエナンチオ選択性の逆転現象

  Tanaka Takanori, Chu Canghu, Morishita Koji, Hayashi Masahiko

  第26回有機合成若手セミナー, Dec. 2006, Japanese, 有機合成化学協会, 大阪, Domestic conference

  Poster presentation


• 1H NMRスペクトル解析を用いたパラジウム-2-(2'-ピリジル)ベンゾアゾール錯体における配位子解離効果の考察

  Haneda Satoshi, Eda Kazuo, Hayashi Masahiko

  第26回有機合成若手セミナー, Dec. 2006, Japanese, 有機合成化学協会, 大阪, Domestic conference

  Poster presentation


• Palladium Complexes Catalyzed Carbon-Carbon Bond Forming Reactions

  Hayashi Masahiko

  The 8th International Symposium on Biotechnology, Metal Complexes and Catalysts, Nov. 2006, English, Haikou, China, International conference

  Invited oral presentation


• New Chiral Schiff Base as Tridentate Ligand for Catalytic Enantioselective Addition of Diethylzinc to Aldehydes

  Tanaka Takanori, Yasuda Yorinobu, Hayashi Masahiko

  The 10th International KYOTO Conference on New Aspects of Organic Chemistry, Nov. 2006, English, 近畿化学協会, Kyoto,JAPAN, International conference

  Poster presentation


• 新規な三座配位シッフ塩基配位子を用いた触媒的不斉アルキル化反応

  Tanaka Takanori, Yasuda Yorinobu, Hayashi Masahiko

  第23回有機合成化学セミナー, Sep. 2006, Japanese, 有機合成化学協会, 函館, Domestic conference

  Poster presentation


• 活性炭―酸素系による酸化反応

  Hayashi Masahiko

  第98回触媒討論会, Sep. 2006, Japanese, 日本触媒学会, 富山, Domestic conference

  Invited oral presentation


• アゾール骨格を持つ窒素配位子-パラジウム錯体を用いた炭素-炭素結合形成反応

  Haneda Satoshi, Gan Zhibin, Eda Kazuo, Hayashi Masahiko

  第23回有機合成化学セミナー, Sep. 2006, Japanese, 有機合成化学協会, 函館, Domestic conference

  Poster presentation


• Catalytic Enantioselective Alkylation Using New Chiral Schiff Base as Tridentate Ligand

  Tanaka Takanori, Yasuda Yorinobu, Hayashi Masahiko

  第53回有機金属化学討論会, Sep. 2006, Japanese, 近畿化学協会, 大阪, Domestic conference

  Poster presentation


• Catalytic coupling reaction using N,N-bidentate palladium complex

  Haneda Satoshi, Gan Zhibin, Eda Kazuo, Hayashi Masahiko

  第53回有機金属化学討論会, Sep. 2006, Japanese, 近畿化学協会, 大阪, Domestic conference

  Poster presentation


• 光学活性シッフ塩基を用いた触媒的不斉アルキル化反応と非線形現象

  Tanaka Takanori, Hayashi Masahiko

  第33回有機反応懇談会, Aug. 2006, Japanese, 有機合成化学協会, 京都, Domestic conference

  Poster presentation


• パラジウム-窒素配位子錯体を用いた炭素-炭素結合形成反応

  Haneda Satoshi, Gan Zhibin, Eda Kazuo, Hayashi Masahiko

  第33回有機反応懇談会, Aug. 2006, Japanese, 有機合成化学協会, 京都, Domestic conference

  Poster presentation


• Novel Oxidation Method Promoted by Activated Carbon

  Hayashi Masahiko, Tanaka Takanori, Kawashita Yuka

  IUPAC 2nd International Symposium on Novel Materials and Synthesis (NMS-II), Jul. 2006, English, IUPAC, 蘭州,中国, International conference

  Invited oral presentation


• パラジウム―イミダゾール系触媒を用いた効率的炭素―炭素結合形成反応

  Hayashi Masahiko

  文部科学省科学研究費特定領域研究「炭素資源の高度分子変換」第一回公開シンポジウム, Jun. 2006, Japanese, 文部科学省, 岡山, Domestic conference

  Invited oral presentation


• Direct and Practical Synthesis of 2-Arylbenzazoles Promoted by Activated Carbon

  Tanaka Takanori, Kawashita Yuka, Hayashi Masahiko

  7th Tetrahedron Symposium, May 2006, English, Tetrahedron, Kyoto,JAPAN, International conference

  Poster presentation


• Oxidation Using Activated Carbon-Oxygen System

  TANAKA T, KAWASHITA Y, HAYASHI M

  8th International Symposium on Organic Reactions, Apr. 2006, English, 入力してください, 神戸, International conference

  Oral presentation


• 活性炭―酸素系による酸化反応を利用したインドール誘導体の合成

  Nomura Yukiko, Hayashi Masahiko

  日本化学会第86春季年会, Mar. 2006, Japanese, 日本化学会, 大阪, Domestic conference

  Oral presentation


• パラジウム触媒を用いた溝呂木-Heck反応におけるアゾール型配位子効果による反応性の考察

  Haneda Satoshi, Gan Zhibin, Eda Kazuo, Hayashi Masahiko

  日本化学会第86春季年会, Mar. 2006, Japanese, 日本化学会, 大阪, Domestic conference

  Oral presentation


• L-セリン由来の新型シッフ塩基―チタン触媒を用いたジケテンのアルデヒドへの不斉付加反応におけるエナンチオ選択性の逆転現象

  Tanaka Takanori, Hayashi Masahiko

  日本化学会第86春季年会, Mar. 2006, Japanese, 日本化学会, 大阪, Domestic conference

  Oral presentation


• 環境調和型酸化反応の開発と芳香族へテロ環の合成

  M. Hayashi

  岡山理科大学ハイテクリサーチセンター講演会招待講演, 2006, Japanese, 入力してください, 岡山, Domestic conference

  Invited oral presentation


• 水素移動反応を利用したアルコールの酸化反応

  TNAKA Takanori, HAYASHI Masahiko

  第25回有機合成若手セミナー, Nov. 2005, Japanese, 神戸大学, Domestic conference

  Oral presentation


• 活性炭̶酸素系による酸化反応を利用した芳香族複素環化合物の効率的合成

  KAWASHITA Yuka, OKUI Ayaka, HAYASHI Masahiko

  第88回有機合成シンポジウム, Nov. 2005, Japanese, 有機合成化学協会, 日本化学会, 日本薬学会, 日本農芸化学会, 早稲田大学国際会議場, Domestic conference

  Oral presentation


• ニトロベンゼンを水素受容体とする水素移動反応を利用したアルコールの酸化反応

  TANAKA Takanori, HAYASHI Masahiko

  第38回酸化反応討論会, Nov. 2005, Japanese, 札幌、北海道大学, Domestic conference

  Oral presentation


• 活性炭－酸素系による酸化反応を利用した芳香族複素環化合物の合成

  川下 由加, 林 昌彦

  日本化学会第85春季年会, Mar. 2005, Japanese, 日本化学会, 横浜（神奈川大学）, Domestic conference

  Oral presentation


• ニトロベンゼンを水素受容体としたアルコールの酸化反応

  田中 孝徳, 川端 裕寿, 林 昌彦

  日本化学会第85春季年会, Mar. 2005, Japanese, 日本化学会, 横浜（神奈川大学）, Domestic conference

  Oral presentation


• Frustrated CDW states in topological crystals

  KUBOKI Kazuhiro, AIMI T, MATSUDA Y, HAYASHI Masahiko

  International Conference on Topology in Ordered Phases, Mar. 2005, English, 未記入, Sapporo., Domestic conference

  Oral presentation


• 2-プロパノール中でのチタンテトライソプロポキシドを触媒に用いる反応

  山下 浩平, 林 昌彦

  日本化学会第85春季年会, Mar. 2005, Japanese, 日本化学会, 横浜（神奈川大学）, Domestic conference

  Oral presentation


• 光学活性シッフ塩基触媒を用いた不斉アルキル化反応

  TANAKA Takanori, YASUDA Yorinobu, HAYASHI Masahiko

  日本化学会第86春季年会, 2005, Japanese, 日本化学会, 千葉、日本大学, Domestic conference

  Oral presentation


• 光学活性シッフ塩基-バナジウム錯体を用いたスルフィド類の不斉酸化反応

  繆 宇平, HAYASHI Masahiko

  日本化学会第86春季年会, 2005, Japanese, 日本化学会, 千葉、日本大学, Domestic conference

  Oral presentation


• 活性炭̶酸素系を用いたイミダゾリン誘導体の酸化反応

  OKUI Ayaka, UEBA Chigusa, HAYASHI Masahiko

  日本化学会第86春季年会, 2005, Japanese, 日本化学会, 日本大学, Domestic conference

  Oral presentation


• パラジウム触媒を用いた水素移動反応におけるニトロベンゼンの役割

  TNAKA Takanori, HAYASHI Masahiko

  第32回有機反応懇談会, 2005, Japanese, 大阪、関西大学, Domestic conference

  Oral presentation


• パラジウ-イミダゾール系触媒を用いた溝呂木-Heck反応

  UEBA Chigusa, HAYASHI Masahiko

  日本化学会第86春季年会, 2005, Japanese, 日本化学会, 千葉、日本大学, Domestic conference

  Oral presentation


• パラジウ-イミダゾール系触媒を用いた溝呂木-Heck反応

  UEBA Chigusa, OKUI Ayaka, HAYASHI Masahiko

  日本化学会第35回複素環化学討論会, 2005, Japanese, 日本化学会, 大阪、大阪大学, Domestic conference

  Oral presentation


• パラジウ-イミダゾール系触媒を用いた溝呂木-Heck反応

  UEBA Chigusa, HAYASHI Masahiko

  第25回有機合成若手セミナー, 2005, Japanese, 日本化学会, 神戸、神戸大学, Domestic conference

  Oral presentation


• Mizoroki-Heck Reaction Using Palladium - imidazole System

  UBA Chigusa, HAYASHI Masahiko

  第52回有機金属討論会, 2005, Japanese, 京都、同志社大学, Domestic conference

  Oral presentation


• Asymmetric Reactions Uising Novel Schiff Base-Metal Complexes

  HAYASHI Masahiko

  復旦大学(Fudan University) 薬学部学術講演, 2005, English, 中国, International conference

  Oral presentation


• Asymmetric Reactions Uising Novel Schiff Base-Metal Complexes

  HAYASHI Masahiko

  南京東南大学 (Southeast University), 2005, English, 中国, International conference

  Oral presentation


• Asymmetric Reactions Uising Novel Schiff Base-Metal Complexes

  HAYASHI Masahiko

  上海交通大学化学化工院学術講演, 2005, English, 中国, International conference

  Oral presentation


• Asymmetric Reactions Uising Novel Schiff Base-Metal Complexes

  HAYASHI Masahiko

  華東理工大学 (China East University of Science and Technology), 2005, English, 中国, International conference

  Oral presentation


• Asymmetric Carbon-carbon Bond Forming Reactions Uising Novel Schiff Base-Metal Complexes

  HAYASHI Masahiko

  中国科学院上海有機化学研究所学術講演, 2005, English, 中国, International conference

  Oral presentation


• 活性炭－酸素系による酸化反応を利用した芳香族複素環化合物の合成

  川下 由加, 上羽 千草, 林 昌彦

  第24回有機合成若手セミナー, Dec. 2004, Japanese, 未記入, 京都大学薬学記念講堂, Domestic conference

  Oral presentation


• チタンテトライソプロポキシドを促進剤に用いるKnoevenagel 型反応

  山下 浩平, 中村 典宏, 林 昌彦

  第24回有機合成若手セミナー, Dec. 2004, Japanese, 未記入, 京都大学薬学記念講堂, Domestic conference

  Oral presentation


• 環境調和型酸化反応の開発と芳香族へテロ環の合成

  林 昌彦

  白鷺セミナー, Nov. 2004, Japanese, 未記入, 大阪, Domestic conference

  Invited oral presentation


• 活性炭_酸素系による芳香族化および酸素導入反応

  川下 由加, 上羽 千草, 林 昌彦

  酸化反応討論会, Nov. 2004, Japanese, 未記入, 関西大学100周年記念館, Domestic conference

  Oral presentation


• 活性炭_酸素系による酸化反応を利用した芳香族複素環化合物の合成

  川下 由加, 上羽 千草, 林 昌彦

  複素環化学討論会, Nov. 2004, Japanese, 未記入, 金沢市観光会館, Domestic conference

  Oral presentation


• グリーンケミストリー

  林 昌彦

  神戸大学理学部サイエンスセミナー2004, Jul. 2004, Japanese, 未記入, Domestic conference

  Others


• 右と左の化学

  林 昌彦

  神戸大学理学部出前講義, May 2004, Japanese, 未記入, Domestic conference

  Others


• Superconducting state on a Mobius strip

  KUBOKI Kazuhiro, HAYASHI Masahiko

  ISSP International Workshop 2003, Aug. 2003, English, 物性研究所, University of Tokyo, International conference

  Oral presentation

• Efficient synthesis of three consecutive chiral building blocks having amino and hydroxy groups

  林 昌彦

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2021 - 31 Mar. 2024

  「三連続したアミノ基とヒドロキシ基をもつキラルビルディングブロックの効率的合成」の課題のもと、令和３年度は二重結合を持つエポキシド4,5-epoxycyclohex-1-eneに対して独自に開発したキラルなN,N-二座配位子（キノリル骨格を含む）と銅からなる触媒存在下に、tert-ブチル過安息香酸を酸化剤に用いてアリル位酸化反応を行なった。 その結果、(3S,4S,5S)-3-benzoyl-4,5-epoxycyclohex-1-eneが84％eeの光学純度で得られた。得られたこの化合物を一旦、ベンゾイル基を脱保護したのち、p-ニトロベンゾイル基へと変換し、再結晶をすることで光学純度を100％ととした。エポキシドを水で開環することで、ヒドロキシ基が三連続のキラルビルディングブロックの合成を達成した。三つのヒドロキシ基の隣接部分はいずれもトランス（アンチ）であった。さらに、アジ化ナトリウムで開環することによってヒドロキシ基、ヒドロキシ基、アミノ基の順で交互にトランスで得られた。 以上は、アリル位に酸素導入を行った結果得られたものである。次にアリル位にアミノ源を導入することで、ヒドロキシ基、ヒドロキシ基、アミノ基およびヒドロキシ基、アミノ基、アミノ基が得られることも確認した。立体はいずれも互いにトランスで、光学純度は100％であった。さらに、残った二重結合をオゾン酸化することによって鎖状化合物への変換も行なった。得られた化合物は鎖状のジアルデヒドのため酸化されやすく、速やかにアセタール保護することで有用化合物合成の中間体として用いることができる。


• 触媒量のPd/C―エチレン系によるフェノールおよびレゾルシノール誘導体の製造法

  林 昌彦

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2017, Principal investigator

  Competitive research funding


• Preparation and Properties of Ionic Liquids from Metal Complexes

  Mochida Tomoyuki, TAKAHASHI Kazuyuki, KUWAHARA Daisuke, TAKAHASHI Masashi, FUJIMORI Hiroki, KATO Keisuke, HAYASHI Masahiko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2012 - 31 Mar. 2016

  Functional metal-containing ionic liquids were synthesized from various cationic metal complexes. First, ionic liquids exhibiting vapochromic, magnetic, and other properties were developed from chelate complexes. Second, a series of ionic liquids were synthesized from metallocenium complexes, and their physical properties and chemical reactivities investigated. Correlations between the crystal structures and thermal properties of metallocenium salts were also investigated.


• Metallocenium Ionic Liquids: Preparation, Electronic Properties, and Chemical Reactivities

  MOCHIDA Tomoyuki, NISHIO Yutaka, KUWAHARA Daisuke, HAYASHI Masahiko, SAITO Toshiaki, KANADANI Chikahide, TAKAHASHI Masashi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2009 - 2011

  A series of metal-containing ionic liquids that are based on metallocenium cations were developed. The thermal properties, magnetic properties, and chemical reactivities of these ionic liquids were investigated.


• 活性炭中のミクロ孔を特異な反応場として用いる新反応の開発

  林 昌彦

  科学研究費補助金／新学術領域研究, 2011, Principal investigator

  Competitive research funding


• メソトリックを利用して一段階反応で複数の不斉中心炭素を構築する方法の新展開

  林 昌彦

  科学研究費補助金／基盤研究(B), 2011, Principal investigator

  Competitive research funding


• 触媒的含フッ素官能基導入反応の新展開

  網井 秀樹

  科学研究費補助金／基盤研究(B), 2010

  Competitive research funding


• イミダゾール骨格を配位子とした金属触媒による高効率的カップリング反応の開発

  林 昌彦

  科学研究費補助金／特定領域研究, 2007, Principal investigator

  Competitive research funding


• 新規なパラジウムーイミダゾール系触媒を用いた効率的炭素ー炭素結合形成反応の開発

  林 昌彦

  科学研究費補助金／特定領域研究, 2006, Principal investigator

  Competitive research funding


• 含フッ素カルベン種の高機能化による有機フッ素化合物合成法の開発

  網井 秀樹

  科学研究費補助金／基盤研究(B), 2006

  Competitive research funding


• 同一の不斉源から両方の鏡像体を高選択的に得る不斉触媒反応系の構築

  林 昌彦

  科学研究費補助金／基盤研究(B), 2005, Principal investigator

  Competitive research funding


• 新規なN,P-型キレート金属錯体を用いた無保護グルカール類の立体選択的変換反応

  林 昌彦

  日本学術振興会, 科学研究費助成事業, 特定領域研究, 神戸大学, 2002 - 2003

  無保護グルカールのアリルアルコールを選択的に酸化して得られるエノン体(ウロース)をグリコシル供与体に用い、触媒量のパラジウム触媒存在下、シアン化トリメチルシリルを作用させると、立体選択的1,4-付加が進行し、対応する3-ケト-1-シアノ糖が高収率かつ高いα選択性でもって得られた。本反応でパラジウム触媒として2価のパラジウムの他、0(ゼロ)価のパラジウムを用いることもできる。グルカールのグリコシル化では、2価のパラジウムのみが触媒活性をもつことと対照的である。そこで、酢酸パラジウムにポスフィン配位子を添加することで、α/β=94/6まで向上させることができた。さらに、本反応で用いたエノン体合成の際に見い出した、Pd/C触媒を用いる酸化反応をピラゾリンからピラゾールへの芳香族化に適用できることを見い出した。その後、これらのピラゾリンは、酸化剤であるPd/Cを一切用いなくとも、活性炭だけで酢酸あるいはキシレン中,加熱するのみで,対応するビラゾールへと変換されることがわかった。本反応では酸素が必須である。活性炭が効率的に酸素を吸着し,反応を促進していると考えられる。この反応はパラジウム触媒-エチレン系と異なり,水素移動型(脱水素)の反応ではなく,酸素の取込みの後,水が抜ける脱水型の反応である。 活性炭-酸素系はジヒドロピリジンからピリジンへの変換,アリールベンズオキサゾール,アリールイミダゾール類の合成(Org.Lett.,5,3713(2003)),アントラセン類の合成(J.Org.Chem.,68,8272 (2003))においても良好な結果を与えた。これらの変換は従来,過マンガン酸や硝酸あるいはDDQを用いて酸化していたが、本法により環境調和型の酸化が実現できた。


• Development of dehydrogenation reaction using palladium catalyst and ethylene system

  HAYASHI Masahiko, MATSUSHITA Akio, HARADA Katsumasa, YAMAZAKI Suzuko, SHIN Jyun-ichi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 2001 - 2003

  Recently reported oxidation process of alcohols using molecular oxygen as an oxidizing agent in the presence of catalytic amount of transition metals such as copper, ruthenium, and palladium compounds will be reviewed. Oxidation of alcohols based on hydrogen transfer reaction between alcohols and simple olefins such as ethylene is also described. That is, some benzylic and allylic alcohols can be converted into the corresponding carbonyl compounds using a catalytic amount of palladium on activated carbon (Pd-C) under ethylene atmosphere. The combination of Pd(OAc)2 and vinyl acetate also works efficiently. Selective oxidation of hydroxy groups on carbohydrates (D-glycals) and steroids as well as simpler systems has been achieved. Oxidative aromatization reaction has been also realized by Pd-C/acetic acid/02 system. 1,3,5-Trisubstituted pyrazolines and Hantzsch 1,4-dihydropyridines were converted into the corresponding pyrazoles and pyridines effectively by the treatment of a catalytic amount of Pd/C in acetic acid under oxygen atmosphere. Direct synthesis of 2-arylbenzoxazoles from 2-aminophenols and aldehydes was achieved in the presence of activated carbon (Darco KB) under oxygen atmosphere. These environmentally benign oxidation methods have potentialities to replace the conventional stoichiometric chromium and other metal oxidizing agents.


• 新規なN,P-型キレート金属錯体を用いた無保護グルカール類の立体選択的変換反応

  林 昌彦

  日本学術振興会, 科学研究費助成事業, 特定領域研究(A), 神戸大学, 2001 - 2001

  無保護グルカールに触媒量(1mol%)のPd(OAc)_2存在下、シアン化トリメチルシリルを作用させたところ、2,3-不飽和-1-シアノ糖が99%収率,α/β=75/25で得られた。この系に、ホスフィン配位子を添加したところ、反応は進行しなくなった。一方、無保護グルカールのアリルアルコールを選択的に酸化して得られる無保護ウロースに、1mol%のPd(OAc)_2存在下、シアン化トリメチルシリルを作用させたところ、3-ケト-1-シアノ糖が96%収率,α/β=88/12で得られた。この系に、P(o-tol)_3を添加したところ、α/β=94/6(82%収率)にまでα選択性が向上した。このように配位子の添加がC-グリコシル化反応の立体選択性に影響を与えうることがわかった。また、これらの結果から無保護グルカールの場合は、零価のパラジウムでは触媒活性がなく、2価のパラジウムがルイス酸的に働いていること、それに対して、無保護ウロースの場合には、零価のパラジウムでも活性があることから、別の機構で進行していることが明らかとなった。さらに、ウロースの場合には配位子の添加による立体化学制御が期待できることもわかった。 上記反応において、無保護グルカールからウロース(エノン体)への酸化の際に開発したPd/C触媒を用いる脱水素化反応を複素環化合物に適用した。すなわち、ピラゾリンからピラゾール、ジヒドロピリミジンからピリミジンへの変換を試みたところ、効率よく脱水素化が進行した。さらに、ピラゾリンからピラゾールへの変換はパラジウム触媒なしでも進行し、この場合には、脱水素化でなく、脱水反応が起きていることも明かとした。


• Stereocontrol utilizing intermolecular interaction

  KATSUKI Tsutomu, HAYASHI Masahiko, KAWABATA Takeo, MIYASHITA Masaaki, OHBA Masaaki, IRIE Ryo, ITO Yoshio, MATSUMURA Yoshihiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas (B), Kyushu University, 1998 - 2000

  Dynamic control of intermolecular interaction is indispensable for achieving highly stereocontrolled reactions. We have developed various new stereocontrolled reactions on the basis of new knowledge on the factors controlling intermolecular reactions. (1) Study with metallosalen complexes The X-ray structural analysis of metallosalen complexes clarified that conformation of the salen ligands is strongly influenced by weak-bond interactions such as OH-π and CH-π interactions and by the presence or absence of a donor ligand. With this knowledge, highly cis- and enantio-selective cyclopropanation was achieved for the first time. Furthermore, new type of asymmetric catalysts activated by photo-irradiation were introduced and, with these complexes, catalytic asymmetric oxidation using molecular oxygen as the terminal oxidant was developed. (2) New methodologies for acyclic stereocontrol Stereospecific and regioselective epoxide-ring opening using new aluminum and borane reagents enabled efficient construction of consecutive asymmetric centers. High efficient construction of chiral quaternary carbons was also developed. With these reactions as key steps, various natural products of complex architectures were synthesized in a highly straightforward manner. (3) Asymmetric induction based on dynamic chirality of enolate structure Direct α-alkylation of optically active α-amino acids was achieved in an enantiospecific manner in the absence of any external chiral sources. Newly introduced nucleophylic catalyst bearing p-aminopyridine moiety enabled highly enantiomer-differentiating acylation. The origin for the observed selectivity was attributed to enantiomer-selective acceleration. (4) Transition metal catalysts in stereoselective carbohydrate synthesis Various carbohydrate derivatives were synthesized efficiently from protected and unprotected glucals by using transition metal catalysts. (5) Desymmetrization of meso-diols and memory of chirality in carbenium ion Asymmetric desymmetrization of meso-diols was achieved efficiently by mono-acylation using chiral binaphthyltin dibromide as a catalyst. Optically acive α-amino acids were converted into optically active aminals via the corresponding acylinium ions in the absence of any external chiral sources. These results disclosed that memory of chirality can be observed in the reactions proceeding through a carbenium intermediate.


• Catalytic asymmetric synthesis of optically active amines and their derivatives

  HAYASHI Masahiko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Yamaguchi University, 1998 - 1999

  For the development of the asymmetric synthesis of optically active amines and their derivatives, we examined the enanioselective addition of trimethylsilyl cyanide to a variety of N-substituted imines. At first, we investigated the reaction catalyzed by chiral Schiff base-titanium alkoxide complexes which was very effective for enantioselective trimethylsilylcyanation of aldehydes. We found that by using chiral titanium complexes, high chemical yield was attained, but only unsatisfied optical yield (20% ee) was obtained. The chiral titanium complex bearing chiral binaphthol derivatives was also found to give only low optical yield. Then we examined the reaction catalyzed by cationic chiral BINAP- palladium complex. By using complex of in-situ preparation and isolated one, low optical yield was obtained in both cases though chemical yield was high. Based on the above results we changed the strategy for the synthesis of optically active amines, that is, catalytic asymmetric allylic amination catalyzed by palladium complexes. We have succeeded in the synthesis of novel palladium catalyst having P, N-bidentate ligands. These new catalyst was found to have high catalytic activity and enantioselectivity in catalytic allylic alkylation. The optical yields of the allylic alkylation products were over 80% ee. At present, the asymmetric amination is being examined.


• Enantioselective Reaction of Diketene to Aldehydes Promoted by Chiral Titanium Complexes

  HAYASHI Masahiko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Yamaguchi University, 1994 - 1995

  Optically Active 5-hydroxy-3-oxoesters can be converted into 6-substituted 4-hydroxy lactones which are common structural components of compactin and mevinolin known as inhibitors of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase. W e recently succeeded in the highly efficient preparation of optically active 5-hydroxy-3-oxoesters by enantioselective reaction of diketene with aldehydes promoted by novel chiral Schiff basetitanium alkoxide complexes. This new procedure provides an efficient method for the synthesis of optically active 5-hydroxy-3-oxoesters in up to 92% enantiomeric excess (ee).


• The Production of Chiral beta-Aminoalcohols to be excellent catalysts for the synthesis of optically active sec-alcohols.

  OGUNI Nobuki, NAKAGAWA Tatsuji, IKEDA Yoshihiko, HAYASHI Masahiko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Developmental Scientific Research (B), YAMAGUCHI UNIVERSITY, 1991 - 1992

  The synthetic methods of optically active sec-alcohols are knwon that asymmetric reductions of unsymmetrical ketones or the asymmetric alkylation of aldehydes are useful methods. The author found the asymmetric alkylation method of aldehydes with dialkylzinc catalyzed by beta-aminoalcohols in 1983. For the first time we studied the synthetic method of optically active 2-hydroxy-3,3-dimethyl-butylamine which was excellent catalysts for alkylation of aldehydes. High yield production ofmonobromination or monochlorination of pinacolone was succeeded by the reaction at 0ﾟC.The reduction of monohalogeno-pinacolone was performed by NaBH_4 in MeOH-H_2O,followed by treatment of alkalline to give t-butylethylene oxide. Thus, obtained t-butylethylene oxide was reacted with N-magnesium salt of sec-amines to give N-dialkyl-2-hydroxy-3,3-dimethyl-1-butylamines in high yield. By this method a variety of beta-aminoalcohols could be prepared. Rac-beta-aminoalcohols was resolved by Sharpless asymmetric oxidation which was very useful method for resolving beta-aminoalcohols. The production of optically active beta-amino-alcohols in industrial scale is now in pending, because the demand of the products is now in step of researching.


• 不斉増幅現象の研究

  小国 信樹, 林 昌彦

  日本学術振興会, 科学研究費助成事業, 一般研究(B), 山口大学, 1990 - 1991

  不斉増幅現象は本申請者の発見した不斉反応における重要な現象の一つである。最初の発見はフランスのKagan教授によるアリルアルコ-ルの不斉エポキシ化反応においてであったが、増幅と呼べるものではなかった。本申請者が発見した光学活性βーアミノアルコ-ルを触媒成分とするジアルキル亜鉛のアルデヒド類への不斉付加反応において、極めて光学純度の低い触媒より光学純度の大変高いアルコ-ル類を得る反応を発見し、この現象を不斉増幅と命名した。この不斉増幅現象の起因を研究して、さらに発展させるのがほんの研究の目的であった。 1。光学活性βーアミノアルコ-ルとジエチル亜鉛のモル比1:1の反応物を溶液中の分子量測定およびNMRスペクトルによって研究をした結果、この反応物は溶液中2量体に会合していることが分かった。しかしラセミのーアミノアルコ-ルとジエチル亜鉛の反応物も同様の研究により2量体であるが、光学活性体からの物とは全く異なった構造を有するメゾ2量体であることが判明した。このメゾ2量体は触媒活性が大変弱いことより、光学活性2量体のみが会合を解き、触媒として働くことが結論された。 2。チタニウムテトライソプロポキシド、Ti(OiPr)_4、と酒石酸エステルとを組み合わせるSharpless触媒を用いて、アルデヒド類の高度な不斉シリルシアノ化反応を触媒量的に進行させる反応を、世界ではじめて本申請者は成功させた。この反応においても本申請者は不斉増幅現象を見いだしイギリス化学会の雑誌(J.Chem.Soc.)に報告した。特に、この反応は医薬品の分野における抗生物質の原料合成、農薬合成および液晶合成および液晶成分の合成等に適応できるので、企業関係からの問い合わせが殺到している。この反応においても、触媒の会合が重要な鍵であることを、触媒のマススペクトルの研究から明かにした。

• フロキサン化合物及びその製造方法（アメリカ)

  MATSUBARA RYOSUKE, HAYASHI MASAHIKO, 安藤 祥大

  15/543547, 15 Dec. 2015, 大学長, US10053435, 21 Aug. 2018

  Patent right


• 光学活性な環状エポキシアリールエステル誘導体の製造法

  HAYASHI MASAHIKO

  特願2009-062952, 16 Mar. 2009, 大学長, 特許5493404, 14 Mar. 2014

  Patent right


• 光学活性な環状アリールエステル誘導体の製造法

  HAYASHI MASAHIKO

  特願2008-225750, 03 Sep. 2008, 大学長, 特許5360801, 13 Sep. 2013

  Patent right


• 新規なＮ，Ｎ，Ｐ－三座シッフ塩基配位子化合物および該化合物を用いた不斉合成

  HAYASHI MASAHIKO, 川村 健二郎

  特願2008-091179, 31 Mar. 2008, 大学長, 特許5294303, 21 Jun. 2013

  Patent right


• イミダゾール系化合物－パラジウム錯体触媒および同触媒を用いる芳香族オレフィン化合物の製造方法

  HAYASHI MASAHIKO, 奥井 あやか, 上羽 千草

  特願2006-046745, 23 Feb. 2006, 大学長, 特許4951250, 16 Mar. 2012

  Patent right