Research activity information

• Oct. 2024 第28回日本基礎理学療法学会学術大会学会長賞

  井上翔太, 李昌欣, 畠山隼平, 姜函林, 若山将弘, 横井諒, 劉武, 森山英樹


• Jun. 2023 第33回日本老年学会総会優秀演題賞

  姜 函林, 井上 翔太, 李 昌欣, 畠山 隼平, 若山 将弘, 高村 大祐, 江口 大輔, 森山 英樹


• Nov. 2021 第26回日本基礎理学療法学会学術大会学会長賞

  畠山 隼平, 井上 翔太, 脇本 祥夫, 李 昌欣, 木村 優介, 姜 函林, 黒木 裕士, 森山 英樹


• May 2019 World Confederation for Physical Therapy (WCPT) Congress 2019, Outstanding Poster Presentation Awards

  Yoshio Wakimoto, Eriko Mizuno, Masato Nomura, Ryota Suzuki, Shota Inoue, Takumi Yakuwa, Changxin Li, Taisei Wakigawa, Toshiya Tsubaki, Junpei Hatakeyama, Sae Kinoshita, Hideki Moriyama


• Dec. 2018 第5回日本運動器理学療法学会学術集会学術集会長賞

  脇本 祥夫, 小原 雄太, 水野 絵里子, 野村 将人, 崎谷 直義, 島谷 俊亮, 鈴木 崚太, 岩澤 裕之, 森山 英樹


• Nov. 2018 第52回日本理学療法学術大会奨励賞

  崎谷 直義, 渡部 大地, 野村 将人, 岩澤 裕之, 島谷 俊亮, 高野 祥子, 小笠原 慎, 脇本 祥夫, 小原 雄太, 鈴木 崚太, 水野 絵理子, 小澤 淳也, 森山 英樹


• Sep. 2017 第3回日本運動器理学療法学会学術集会優秀賞

  小原 雄太, 崎谷 直義, 小澤 淳也, 渡部 大地, 野村 将人, 岩澤 裕之, 脇本 祥夫, 高野 祥子, 島谷 俊亮, 森山 英樹


• May 2012 日本理学療法士協会, 第3回学術誌掲載論文優秀賞

  森山 英樹, 増子 潤, 金村 尚彦, 木藤 伸宏, 小澤 淳也, 今北 英高, 高栁 清美, 伊藤 俊一, 磯崎 弘司, 出家 正隆


• Dec. 2009 埼玉県立大学, 若手教員研究奨励賞

  森山 英樹


• Dec. 2008 埼玉県立大学, 若手教員研究奨励賞

  森山 英樹


• Mar. 2006 広島大学, 広島大学学長表彰（学術研究活動）

  森山 英樹

  Others

• Transcutaneous carbon dioxide improves joint inflammation and articular cartilage degeneration in rat osteoarthritis models

  Changxin Li, Hideki Moriyama, Shota Inoue, Junpei Hatakeyama, Daisuke Takamura, Hanlin Jiang, Yoshitada Sakai, Toshihiro Akisue

  Corresponding, Jul. 2025, Bone & Joint Research, in press, English

  [Refereed]

  Scientific journal


• Effects of exercise on mental health in circadian rhythm disruption in mice

  hunxiao He, Masahiro Wakayama, Hanlin Jiang, Tingrui Zhao, Yifan Zhang, Bin Liu, Hideki Moriyama

  Corresponding, Jul. 2025, Journal of Affective Disorders, in press, English

  [Refereed]

  Scientific journal


• Effects of electrical muscle stimulation on cognitive function and neuropathology in senescence-accelerated mouse (SAMP8) model of aging-associated cognitive decline

  Hanlin Jiang, Tingrui Zhao, Chunxiao He, Bin Liu, Wanlin Ai, Yuxin Chen, Hideki Moriyama

  Corresponding, May 2025, GeroScience, in press, English

  [Refereed]

  Scientific journal


• Effects of aging and resistance exercise on muscle strength, physiological properties, longevity proteins, and telomere length in SAMP8 mice

  Hanlin Jiang, Shota Inoue, Junpei Hatakeyama, Peng Liu, Tingrui Zhao, Yifan Zhang, Bin Liu, Chunxiao He, Hideki Moriyama

  Corresponding, Apr. 2025, Biogerontology, 26(2) (2), 88, English

  [Refereed]

  Scientific journal


• Effects of ankle dorsiflexion training on anticipatory postural adjustments during gait initiation in patients with Parkinson’s disease

  Atsushi Nagai, Kohei Marumoto, Kota Ohata, Shoma Takasaki, Hideki Moriyama

  Corresponding, Jan. 2025, Gait & Posture, 117, 109 - 114, English

  [Refereed]

  Scientific journal


• Exercise-induced interactions between skeletal muscle and bone via myokines and osteokine in mice: Role of FNDC5/irisin, IGF-1, and osteocalcin

  Junpei Hatakeyama, Shota Inoue, Hanlin Jiang, Ryo Yokoi, Hideki Moriyama

  Corresponding, Jan. 2025, Bone, 190, 117314, English

  [Refereed]

  Scientific journal


• Circulating miR-29c, miR-195, and miR-486 are objective indicators to determine the moderate intensity of resistance exercise

  Daisuke Takamura, Kentaro Iwata, Shota Inoue, Junpei Hatakeyama, Hideki Moriyama

  Corresponding, Dec. 2024, Cureus, 16(12) (12), e76212, English

  [Refereed]

  Scientific journal


• Disuse atrophy of articular cartilage can be restored by mechanical reloading in mice

  Masato Nomura, Hideki Moriyama, Yoshio Wakimoto, Yasushi Miura

  Sep. 2024, Molecular Biology Reports, 51(1) (1), 1018, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of aerobic exercise at different intensities on articular cartilage in mice

  Chunxiao He, Toshiya Tsubaki, Shota Inoue, Junpei Hatakeyama, Hanlin Jiang, Hideki Moriyama

  Corresponding, Sep. 2024, Physiology International, 111(3) (3), 271 - 286, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Change in body weight is positively related to the change in muscle mass of the quadriceps in older inpatients with severely low BMI according to the GLIM criteria

  Naoki Akazawa, Keita Funai, Toshikazu Hino, Ryota Tsuji, Wataru Tamura, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Aug. 2024, BMC Geriatrics, 24(1) (1), 711, English

  [Refereed]

  Scientific journal


• Effects of different combinations of mechanical loading intensity, duration, and frequency on the articular cartilage in mice

  Yoshio Wakimoto, Yasushi Miura, Shota Inoue, Masato Nomura, Hideki Moriyama

  Last, Jul. 2024, Molecular Biology Reports, 51(1) (1), 862, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of different exercise modes and intensities on cognitive performance, adult hippocampal neurogenesis, and synaptic plasticity in mice

  Hanlin Jiang, Yusuke Kimura, Shota Inoue, Changxin Li, Junpei Hatakeyama, Masahiro Wakayama, Daisuke Takamura, Hideki Moriyama

  Corresponding, Jul. 2024, Experimental Brain Research, 242(7) (7), 1709 - 1719, English

  [Refereed]

  Scientific journal


• Development of patellofemoral osteoarthritis with knee joint malalignment and lateral patellar dislocation after hindlimb suspension in growing rats

  Junya Ozawa, Airi Ikeda, Marina Kanehara, Hideki Moriyama, Akinori Kaneguchi

  Jul. 2024, Journal of Orthopaedic Research, 42(7) (7), 1490 - 1500, English

  [Refereed]

  Scientific journal


• Effects of acute- and long-term aerobic exercises at different intensities on bone in mice

  Junpei Hatakeyama, Shota Inoue, Changxin Li, Daisuke Takamura, Hanlin Jiang, Hiroshi Kuroki, Hideki Moriyama

  Corresponding, Mar. 2024, Journal of Bone and Mineral Metabolism, 42(2) (2), 185 - 195, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Increased intramuscular adipose tissue of the quadriceps at admission is more strongly related to activities of daily living recovery at discharge compared to muscle mass loss in older patients with aspiration pneumonia

  Naoki Akazawa, Keita Funai, Toshikazu Hino, Ryota Tsuji, Wataru Tamura, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Jan. 2024, BMC Geriatrics, 24(1) (1), 107, English

  [Refereed]

  Scientific journal


• Cut-off values of preoperative knee extensor strength and hip abductor strength for predicting good walking ability after total knee arthroplasty

  Daisuke Takamura, Kentaro Iwata, Yuma Yajima, Kentaro Suzuki, Kanta Satsuki, Tsubasa Itoh, Tadashi Yasuda, Hideki Moriyama

  Corresponding, Jan. 2024, Archives of Orthopaedic and Trauma Surgery, 144(1) (1), 377 - 384, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Increase in protein intake is related to decreasing intramuscular adipose tissue of the quadriceps in older inpatients: A longitudinal study

  Naoki Akazawa, Keita Funai, Toshikazu Hino, Ryota Tsuji, Wataru Tamura, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Dec. 2023, Clinical Nutrition ESPEN, 58, 136 - 143, English

  [Refereed]

  Scientific journal


• Higher-intensity ultrasound accelerates fracture healing via mechanosensitive ion channel Piezo1

  Shota Inoue, Shota Inoue, Changxin Li, Junpei Hatakeyama, Hanlin Jiang, Hiroshi Kuroki, Hideki Moriyama

  Corresponding, Dec. 2023, Bone, 177, 116916, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Greater intramuscular adipose tissue of the quadriceps in older inpatients at post-acute hospital admission is more strongly related to a low rate of home discharge than a loss of muscle mass

  Naoki Akazawa, Keita Funai, Toshikazu Hino, Ryota Tsuji, Wataru Tamura, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Jun. 2023, Scientific Reports, 13(1) (1), 10021, English

  [Refereed]

  Scientific journal


• Effects of uphill and downhill walking on post-traumatic osteoarthritis development in mice

  Changxin Li, Shota Inoue, Junpei Hatakeyama, Hanlin Jiang, Daisuke Takamura, Osamu Shirado, Hideki Moriyama

  Corresponding, May 2023, Journal of Physiology, 601(10) (10), 1781 - 1795, English

  [Refereed]

  Scientific journal


• Effects of different modes and intensities of exercise on longevity proteins in middle-aged mouse skeletal muscle

  Shota Inoue, Kyohei Matsuura, Daisuke Eguchi, Masahiro Wakayama, Kosuke Ono, Hanlin Jiang, Hideki Moriyama

  Corresponding, May 2023, Physiology International, 110(2) (2), 150 - 159, English

  [Refereed]

  Scientific journal


• Muscular echo-intensity of the quadriceps by ultrasound is more related to improvement of gait independence than muscle thickness in older inpatients

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Feb. 2023, Journal of Nutrition, Health and Aging, 27(2) (2), 103 - 110, English

  [Refereed]

  Scientific journal


• Longitudinal relationship between muscle mass and intramuscular adipose tissue of the quadriceps in older inpatients at different activities of daily living levels

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Corresponding, Jan. 2023, Clinical Nutrition ESPEN, 53(1) (1), 175 - 181, English

  [Refereed]

  Scientific journal


• Need for detailed analysis of quadriceps intramuscular adipose tissue and nutritional status

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Elsevier BV, Dec. 2022, Clinical Nutrition, 41(12) (12), 3124 - 3125, English

  [Refereed][Invited]

  Scientific journal


• The degree of recovery in swallowing ability in older inpatients with aspiration pneumonia is related to intramuscular adipose tissue of the quadriceps than to muscle mass

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Oct. 2022, PLoS One, 17(10) (10), e0275810, English

  [Refereed]

  Scientific journal


• Increase in muscle mass of the quadriceps is related to decrease in intramuscular adipose tissue in convalescent stroke patients: a longitudinal study

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Oct. 2022, Clinical Nutrition ESPEN, 51, 199 - 206, English

  [Refereed]

  Scientific journal


• Higher malnutrition risk in older inpatients who are referred to the department of rehabilitation is related to increase of intramuscular adipose tissue: A prospective study

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Oct. 2022, Clinical Nutrition, 41(10) (10), 2087 - 2093, English

  [Refereed]

  Scientific journal


• Nutritional and swallowing statuses but not intramuscular adipose tissue and muscle mass are related to activities of daily living in older inpatients who are judged as severely low body mass index in the Global Leadership Initiative on Malnutrition criteria

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Jun. 2022, Clinical Nutrition ESPEN, 49, 411 - 416, English

  [Refereed]

  Scientific journal


• Higher body mass index in hospitalized older patients is related to higher muscle quality

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, May 2022, Journal of Nutrition, Health and Aging, 26(5) (5), 495 - 500, English

  [Refereed]

  Scientific journal


• Relationship between muscle mass and fraction of intramuscular adipose tissue of the quadriceps in older inpatients

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Feb. 2022, PLoS One, 17(2) (2), e0263973, English

  [Refereed]

  Scientific journal


• Longitudinal relationship between intramuscular adipose tissue of the quadriceps and activities of daily living in older inpatients

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Dec. 2021, Journal of Cachexia, Sarcopenia and Muscle, 12(6) (6), 2231 - 2237, English

  [Refereed]

  Scientific journal


• Effects of cyclic tensile strain and microgravity on the distribution of actin fiber and Fat1 cadherin in murine articular chondrocytes

  Junpei Hatakeyama, Masato Nomura, Yoshio Wakimoto, Shota Inoue, Changxin Li, Daisuke Takamura, Toshihiro Akisue, Hideki Moriyama

  Corresponding, Dec. 2021, Journal of Biomechanics, 129, 110774, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Greater quadriceps muscle mass at post-acute care admission is associated with better swallowing ability at discharge among adults with stroke

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Dec. 2021, Journal of the American Medical Directors Association, 22(12) (12), 2486 - 2490, English

  [Refereed]

  Scientific journal


• Intramuscular adipose tissue of the quadriceps is more strongly related to recovery of swallowing ability than muscle mass in older inpatients: A prospective study

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Nov. 2021, Nutrition, 91-92, 111364, English

  [Refereed]

  Scientific journal


• Increased intramuscular adipose tissue of the quadriceps is related to decreased activities of daily living in patients who have had a stroke

  Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Masaki Kishi, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Oct. 2021, Nutrition, 90, 111277, English

  [Refereed]

  Scientific journal


• Relationship between early physical activity after total knee arthroplasty and postoperative physical function: are these related?

  Daisuke Takamura, Kentaro Iwata, Tatsuya Sueyoshi, Tadashi Yasuda, Hideki Moriyama

  Corresponding, Sep. 2021, Knee Surgery and Related Research, 33, 35, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.

  Aug. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazine

  [Refereed]

  Scientific journal


• Research for construction of gait abnormality evaluation based on observation in patients with knee osteoarthritis: item characteristics, factor validity, concurrent validity and inter-rater reliability

  山科俊輔, 山科俊輔, 原田和宏, 原田和宏, 玉利光太郎, 田中亮, 山田英司, 森山英樹, 阿南雅也, 京極真, 京極真, 河村顕治, 河村顕治

  Aug. 2021, 理学療法ジャーナル, 55(8) (8), 922 - 930, Japanese

  [Refereed]

  Scientific journal


• Intramuscular adipose tissue in the quadriceps is more strongly related to recovery of ADL than muscle mass in older inpatients

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Aug. 2021, Journal of Cachexia, Sarcopenia and Muscle, 12(4) (4), 891 - 899, English

  [Refereed]

  Scientific journal


• Utilization of mechanical stress to treat osteoporosis: the effects of electrical stimulation, radial extracorporeal shock wave, and ultrasound on experimental osteoporosis in ovariectomized rats

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Corresponding, Aug. 2021, Calcified Tissue International, 109(2) (2), 215 - 229, English, International magazine

  [Refereed]

  Scientific journal


• Effects of ultrasound, radial extracorporeal shock wave, and electrical stimulation on rat bone defect healing

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.

  Corresponding, Aug. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between aging and intramuscular adipose tissue in older inpatients

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Akemi Hioka, Hideki Moriyama

  Last, Jun. 2021, Journal of the American Medical Directors Association, 22(6) (6), 1287 - 1291, English

  [Refereed]

  Scientific journal


• Changes in quadriceps thickness and echo intensity in chronic stroke survivors: A 3-year longitudinal study

  Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Masaki Kishi, Kimiyuki Tamura, Hideki Moriyama

  Last, Mar. 2021, Journal of Stroke and Cerebrovascular Diseases, 30(3) (3), 105543, English

  [Refereed]

  Scientific journal


• Increased intramuscular adipose tissue of the quadriceps is more strongly related to declines in ADL than is loss of muscle mass in older inpatients

  Naoki Akazawa, Naomi Okawa, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Hideki Moriyama

  Last, Mar. 2021, Clinical Nutrition, 40(3) (3), 1381 - 1387, English

  [Refereed]

  Scientific journal


• Using GLIM criteria, cutoff value for low BMI in Asian populations discriminates high or low muscle mass: A cross-sectional study

  Naoki Akazawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Hideki Moriyama

  Last, Jan. 2021, Nutrition, 81, 110928, English

  [Refereed]

  Scientific journal


• Transcutaneous application of carbon dioxide improves contractures after immobilization of rat knee joint

  Shota Inoue, Hideki Moriyama, Yoshio Wakimoto, Changxin Li, Junpei Hatakeyama, Taisei Wakigawa, Yoshitada Sakai, Toshihiro Akisue

  OBJECTIVE: Joint contractures are a major complication following joint immobilization. However, no fully effective treatment has yet been found. Recently, carbon dioxide (CO2) therapy was developed and verified this therapeutic application in various disorders. We aimed to verify the efficacy of transcutaneous CO2 therapy for immobilization-induced joint contracture. METHOD: Twenty-two Wistar rats were randomly assigned to three groups: caged control, those untreated after joint immobilization, and those treated after joint immobilization. The rats were treated with CO2 for 20 min once a daily either during immobilization, (prevention) or during remobilization after immobilization (treatment). Knee extension motion was measured with a goniometer, and the muscular and articular factors responsible for contractures were calculated. We evaluated muscle fibrosis, fibrosis-related genes (collagen Type 1α1 and TGF-β1) in muscles, synovial intima's length, and fibrosis-related proteins (Type I collagen and TGF-β1) in the joint capsules. RESULTS: CO2 therapy for prevention and treatment improved the knee extension motion. Muscular and articular factors decreased in rats of the treatment group. The muscular fibrosis of treated rats decreased in the treatment group. Although CO2 therapy did not repress the increased expression of collagen Type 1α1, the therapy decreased the expression of TGF-β1 in the treatment group. CO2 therapy for treatment improved the shortening of the synovial membrane after immobilization and decreased the immunolabeling of TGF-β1 in the joint capsules. CONCLUSIONS: CO2 therapy may prevent and treat contractures after joint immobilization, and appears to be more effective as a treatment strategy for the deterioration of contractures during remobilization.

  Corresponding, Dec. 2020, Physical Therapy Research, 23(2) (2), 113 - 122, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Higher malnutrition risk is related to increased intramuscular adipose tissue of the quadriceps in older inpatients: A cross-sectional study

  Naoki Akazawa, Naomi Okawa, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Hideki Moriyama

  Last, Aug. 2020, Clinical Nutrition, 39(8) (8), 2586 - 2592, English

  [Refereed]

  Scientific journal


• 経皮的炭酸ガス吸収療法が関節可動域に及ぼす効果

  畠山 隼平, 森山 英樹, 伊藤 拓海, 李 昌欣, 脇本 祥夫, 井上 翔太, 脇川 大誠, 椿 俊哉, 木下 沙英, 野村 将人, 酒井 良忠, 秋末 敏宏

  Corresponding, 専門リハビリテーション研究会, Jun. 2020, 専門リハビリテーション, 19, 21 - 28, Japanese

  [Refereed]

  Scientific journal


• Quantitative features of intramuscular adipose tissue of the quadriceps and their association with gait independence in older inpatients: A cross-sectional study

  Naoki Akazawa, Naomi Okawa, Masaki Kishi, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Hideki Moriyama

  Last, 2020, Nutrition, 71, 110600, English

  [Refereed]

  Scientific journal


• Effects of hypertonia on contracture development in rat spinal cord injury

  Hideki Moriyama, Junya Ozawa, Takumi Yakuwa, Shota Inoue, Taisei Wakigawa, Nobuhiro Kito, Yoshitada Sakai, Toshihiro Akisue

  STUDY DESIGN: Experimental animal study. OBJECTIVES: Spastic hypertonia is originally believed to cause contractures from clinical observations. Botulinum toxin is effective for the treatment of spasticity and is widely used in patients who have joints with contractures. Using an established rat model with knee contractures after spinal cord injuries, we aimed to verify whether hypertonia contributes to contracture development, and the botulinum toxin improves structural changes in muscles and joint components responsible for contractures. SETTING: University laboratory in Japan. METHODS: To evaluate the effect of hypertonia on contracture development, the rats received botulinum toxin injections after spinal cord injuries. Knee extension motion was measured with a goniometer applying a standardized torque under anesthesia, and the contribution by muscle or non-muscle structures to contractures were calculated by measuring joint motion before and after the myotomies. We quantitatively measured the muscle atrophy, muscle fibrosis, and synovial intima length. RESULTS: Botulinum toxin injections significantly improved contractures, whereas did not completely prevent contracture development. Botulinum toxin was effective in improving the muscular factor, but little difference in the articular factor. Spinal cord injuries induced muscle atrophy, and botulinum toxin significantly accelerated muscle atrophy and fibrosis. The synovial intima length decreased significantly after spinal cord injuries, and botulinum toxin did not improve this shortening. CONCLUSIONS: This animal study provides new evidence that hypertonia is not the sole cause rather is the partial contributor of contractures after spinal cord injuries. Furthermore, botulinum toxin has adverse effects in the muscle.

  Oct. 2019, Spinal Cord, 57(10) (10), 850 - 857, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide improves contractures after spinal cord injury in rats

  Shota Inoue, Hideki Moriyama, Takumi Yakuwa, Eriko Mizuno, Ryota Suzuki, Masato Nomura, Yoshitada Sakai, Toshihiro Akisue

  BACKGROUND: Joint contractures are a major complication in patients with spinal cord injuries. Positioning, stretching, and physical therapy are advocated to prevent and treat contractures; however, many patients still develop them. Joint motion (exercise) is crucial to correct contractures. Transcutaneous carbon dioxide (CO2) therapy was developed recently, and its effect is similar to that of exercise. This therapy may be an alternative or complementary approach to exercise. QUESTION/PURPOSES: Using an established model of spinal cord injury in rats with knee flexion contractures, we sought to clarify whether transcutaneous CO2 altered (1) contracture, as measured by ROM; (2) muscular and articular factors contributing to the loss of ROM; (3) fibrosis and fibrosis-related gene expression in muscle; and (4) the morphology of and fibrosis-related protein expression in the joint capsule. METHODS: Thirty-six Wistar rats were divided into three equal groups: caged control, those untreated after spinal cord injury, and those treated with CO2 after spinal cord injury. The rats were treated with CO2 from either the first day (prevention) or 15th day (treatment) after spinal cord injury for 2 or 4 weeks. The hindlimbs of rats in the treated group were exposed to CO2 gas for 20 minutes once daily. Knee extension ROM was measured with a goniometer and was measured again after myotomy. We calculated the muscular and articular factors responsible for contractures by subtracting the post-myotomy ROM from that before myotomy. We also quantified histologic muscle fibrosis and evaluated fibrosis-related genes (collagen Type 1, α1 and transforming growth factor beta) in the biceps femoris muscle with real-time polymerase chain reaction. The synovial intima's length was measured, and the distribution of fibrosis-related proteins (Type I collagen and transforming growth factor beta) in the joint capsule was observed with immunohistochemistry. Knee flexion contractures developed in rats after spinal cord injuries at all timepoints. RESULTS: CO2 therapy improved limited-extension ROM in the prevention group at 2 weeks (22° ± 2°) and 4 weeks (29° ± 1°) and in the treatment group at 2 weeks (31° ± 1°) compared with untreated rats after spinal cord injuries (35° ± 2°, mean difference, 13°; 39° ± 1°, mean difference, 9°; and 38° ± 1°, mean difference, 7°, respectively) (95% CI, 10.50-14.86, 8.10-10.19, and 4.73-9.01, respectively; all p < 0.001). Muscular factors decreased in treated rats in the prevention group at 2 weeks (8° ± 2°) and 4 weeks (14°± 1°) and in the treatment group at 2 weeks (14 ± 1°) compared with untreated rats (15° ± 1°, 4.85-9.42; 16° ± 1°, 1.24-3.86; and 17° ± 2°, 1.16-5.34, respectively; all p < 0.05). The therapy improved articular factors in the prevention group at 2 weeks (4° ± 1°) and 4 weeks (6° ± 1°) and in the treatment group at 2 weeks (8° ± 1°) compared with untreated rats (10° ± 1°, 4.05-7.05; 12° ± 1°, 5.18-8.02; and 11° ± 2°, 1.73-5.50, respectively; all p < 0.05). CO2 therapy decreased muscle fibrosis in the prevention group at 2 weeks (p < 0.001). The expression of collagen Type 1, α1 mRNA in the biceps femoris decreased in treated rats in the prevention group at 2 and 4 weeks compared with untreated rat (p = 0.002 and p = 0.008, respectively), although there was little difference in the expression of transforming growth factor beta (p > 0.05). CO2 therapy did not improve shortening of the synovial intima at all timepoints (all p > 0.05). CO2 therapy decreased transforming growth factor beta immunolabeling in joint capsules in the rats in the prevention group at 2 weeks. The staining intensity and Type I collagen pattern showed no differences among all groups at all timepoints. CONCLUSION: CO2 therapy may be useful for preventing and treating contractures after spinal cord injuries. CO2 therapy particularly appears to be more effective as a prevention and treatment strategy in early-stage contractures before irreversible degeneration occurs, as shown in a rat model. CLINICAL RELEVANCE: Our findings support the idea that CO2 therapy may be able to improve the loss of ROM after spinal cord injury.

  Corresponding, Aug. 2019, Clinical orthopaedics and related research, 477(8) (8), 1934 - 1946, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Dysphagia is more strongly associated with increased intramuscular adipose tissue of the quadriceps than with loss of muscle mass in older inpatients

  Naoki Akazawa, Naomi Okawa, Toshikazu Hino, Ryota Tsuji, Kimiyuki Tamura, Hideki Moriyama

  Last, May 2019, Nutrition Research, 65, 71 - 78, English

  [Refereed]

  Scientific journal


• Low body mass index negatively affects muscle mass and intramuscular fat of chronic stroke survivors

  Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Kimiyuki Tamura, Hideki Moriyama

  Last, Jan. 2019, PLoS One, 14(1) (1), e0211145, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationships between muscle mass, intramuscular adipose and fibrous tissues of the quadriceps, and gait independence in chronic stroke survivors: a cross-sectional study

  Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Kimiyuki Tamura, Atsushi Hayase, Hideki Moriyama

  Last, Nov. 2018, Physiotherapy, 104(4) (4), 438 - 445, English

  [Refereed]

  Scientific journal


• Muscle mass and intramuscular fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study

  Akazawa N, Harada K, Okawa N, Tamura K, Moriyama H

  Aug. 2018, PLoS One, e0201789, 13(8) (8), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Muscle mass and intramuscular fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: a cross-sectional study

  Naoki Akazawa, Kazuhiro Harada, Naomi Okawa, Kimiyuki Tamura, Hideki Moriyama

  Last, Aug. 2018, PLoS One, 13(8) (8), e0201789, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of different exercises on the growth plate in young growing mice

  Eriko Mizuno, Yoshio Wakimoto, Masato Nomura, Yuta Kohara, Shunsuke Shimaya, Ryota Suzuki, Hideki Moriyama

  Corresponding, Jun. 2018, Biomedical Research, 29(12) (12), 2620 - 2626, English

  [Refereed]

  Scientific journal


• Accumulation of advanced-glycation end products (AGEs) accelerates arthrogenic joint contracture in immobilized rat knee.

  Junya Ozawa, Akinori Kaneguchi, Kengo Minamimoto, Ryo Tanaka, Nobuhiro Kito, Hideki Moriyama

  Joint mobility decreases in the elderly and in diabetics, this process is thought to be caused by accumulation of advanced-glycation end products (AGEs). Here, we aimed to elucidate the role of AGEs in joint contracture formation in rat knees. Rats were injected with ribose or saline into the knees twice weekly for 8 weeks. Pentosidine (AGE) levels were measured in the knee-joint tissues. After serial injections, rats were subjected to unilateral knee-joint immobilization in a flexion position for various periods. At day 21, the passive knee ranges of motions (ROMs) were measured. Knee joint histopathology were assessed, and the expression of fibrotic genes in the posterior joint capsules was examined using real-time PCR. Ribose injection induced a 7.0-fold increase in pentosidine levels relative to saline injection. Joint immobilization resulted in equal myogenic ROM restriction in both groups. Arthrogenic ROM restriction was greater with ribose injection in the immobilized joints (p < 0.05), but was not affected in nonimmobilized joints. Type-I (COL1A1) and type-III (COL3A1) collagen gene expression increased significantly in immobilized joints relative to nonimmobilized joints in the ribose group, but was not affected in the saline group. Ribose injection increased COL1A1 expression slightly and COL3A1 expression significantly in immobilized joints. Histologically, inflammatory changes appeared at day 3 of immobilization and peaked at day 7. These responses trended to be more severe and prolonged in the ribose group than in the saline group. Our data provide evidence for a causal relationship between AGEs and joint contracture formation following immobilization. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:854-863, 2018.

  Last, Mar. 2018, Journal of Orthopaedic Research, 36(3) (3), 854 - 863, English, International magazine

  [Refereed]

  Scientific journal


• Determining the cut-off value for knee extensor strength for identifying independence in gait in chronic stroke survivors

  Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki Moriyama

  Last, Nov. 2017, Journal of Rehabilitation Medicine, 49(9) (9), 765 - 767, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationships between intramuscular fat, muscle strength and gait independence in older women: A cross-sectional study

  Naoki Akazawa, Naomi Okawa, Kimiyuki Tamura, Hideki Moriyama

  Last, Oct. 2017, Geriatrics & Gerontology International, 17(10) (10), 1683 - 1688, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Mechanical stress by spasticity accelerates fracture healing after spinal cord injury

  Naoyoshi Sakitani, Hiroyuki Iwasawa, Masato Nomura, Yasushi Miura, Hiroshi Kuroki, Junya Ozawa, MORIYAMA HIDEKI

  Corresponding, Sep. 2017, Calcified Tissue International, 101(4) (4), 384 - 395, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Nociception contributes to the formation of myogenic contracture in the early phase of adjuvant-induced arthritis in a rat knee

  Akinori Kaneguchi, Junya Ozawa, Hideki Moriyama, Kaoru Yamaoka

  Jul. 2017, Journal of Orthopaedic Research, 35(7) (7), 1404 - 1413, English

  [Refereed]

  Scientific journal


• Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice

  M. Nomura, N. Sakitani, H. Iwasawa, Y. Kohara, S. Takano, Y. Wakimoto, H. Kuroki, H. Moriyama

  Corresponding, May 2017, Osteoarthritis and Cartilage, 25(5) (5), 727 - 736, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Stretching After Heat But Not After Cold Decreases Contractures After Spinal Cord Injury in Rats

  Hiroyuki Iwasawa, Masato Nomura, Naoyoshi Sakitani, Kosuke Watanabe, Daichi Watanabe, Hideki Moriyama

  Corresponding, Dec. 2016, Clinical Orthopaedics and Related Research, 474(12) (12), 2692 - 2701, English

  [Refereed]

  Scientific journal


• Effect of Changing the Joint Kinematics of Knees With a Ruptured Anterior Cruciate Ligament on the Molecular Biological Responses and Spontaneous Healing in a Rat Model

  Takanori Kokubun, Naohiko Kanemura, Kenji Murata, Hideki Moriyama, Sadao Morita, Tetsuya Jinno, Hidetoshi Ihara, Kiyomi Takayanagi

  Nov. 2016, American Journal of Sports Medicine, 44(11) (11), 2900 - 2910, English

  [Refereed]

  Scientific journal


• Cyclooxygenase-2 inhibitor celecoxib attenuates joint contracture following immobilization in rat knees

  Junya Ozawa, Akinori Kaneguchi, Ryo Tanaka, Nobuhiro Kito, Hideki Moriyama

  Last, Oct. 2016, BMC Musculoskeletal Disorders, 17(1) (1), 1 - 10, English

  [Refereed]

  Scientific journal


• Effects of long-term self-massage at the musculotendinous junction on hamstring extensibility, stiffness, stretch tolerance, and structural indices: A randomized controlled trial

  Naoki Akazawa, Naomi Okawa, Masaki Kishi, Kiyoshi Nakatani, Katsuya Nishikawa, Daichi Tokumura, Yuji Matsui, Hideki Moriyama

  Corresponding, Sep. 2016, Physical Therapy in Sport, 21, 38 - 45, English

  [Refereed]

  Scientific journal


• Effects of exercise therapy on walking ability in individuals with knee osteoarthritis: a systematic review and meta-analysis of randomised controlled trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Hideki Moriyama

  Last, Jan. 2016, Clinical Rehabilitation, 30(1) (1), 36 - 52, English

  [Refereed]

  Scientific journal


• Does exercise therapy improve the health-related quality of life of people with knee osteoarthritis? A systematic review and meta-analysis of randomized controlled trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Hideki Moriyama

  Last, Oct. 2015, Journal of Physical Therapy Science, 27(10) (10), 3309 - 3314, English

  [Refereed]

  Scientific journal


• Tidal volume and diaphragm muscle activity in rats with cervical spinal cord injury

  Hidetaka Imagita, Akira Nishikawa, Susumu Sakata, Yasue Nishii, Akira Minematsu, Hideki Moriyama, Naohiko Kanemura, Hanae Shindo

  Mar. 2015, Journal of Physical Therapy Science, 27(3) (3), 791 - 794, English

  [Refereed]

  Scientific journal


• Structures responsible for the formation of knee joint contracture secondary to adjuvant-induced arthritis in a rat model

  Akinori Kaneguchi, Junya Ozawa, MORIYAMA HIDEKI, Kaoru Yamaoka

  Mar. 2015, 医療工学雑誌, 9, 1 - 9, English

  [Refereed]

  Scientific journal


• Interaction between gastrocnemius muscle weakness and moderate exercise deteriorates joint integrity in rat knee

  J. Ozawa, A. Kaneguchi, R. Tanaka, S. Kawamata, T. Kurose, H. Moriyama, N. Kito, N. Kawaguchi, N. Matsuura

  Feb. 2015, Scandinavian Journal of Medicine & Science in Sports, 25(1) (1), E11 - E19, English

  [Refereed]

  Scientific journal


• 変形性膝関節症罹患者に対する運動療法は治療開始150日を超えても有効か? システマティックレビュー

  TANAKA Ryo, OZAWA Junya, KITO Nobuhiro, MORIYAMA Hideki, MINAMIARITA Kurumi

  Objective : We performed a systematic review to investigate improvements in body function and structure, activity, and health-related quality of life from exercise programs of >150 days' duration in patients with knee osteoarthritis (OA). Methods : We collected data on randomized controlled trials (RCTs) comparing the effects of exercise intervention with those of either nonintervention or psychoeducational intervention in patients with knee OA. Data were collected on pain, stiffness, muscle strength, range of motion, flexibility, maximal oxygen uptake, proprioception, time to climb a flight of stairs, disability as assessed by the Western Ontario and McMaster Universities Arthritis Index (WOMAC), walking distance (e.g., 6-min walking-distance test), walking time (e.g., time to walk arbitrary distances), walking velocity, and health-related quality of life assessed using the SF-36^® Health Survey (SF-36). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system was used to determine the quality of the evidence. Results: Forty-one RCTs were identified. Outcomes that were significantly affected by exercise programs of >150 days were knee flexion muscle strength at a functional level, time to climb a flight of stairs and walking distance at activity level, and SF-36 General Health, Physical Functioning, Role-Physical, and Bodily Pain scales. The quality of evidence for these outcomes was moderate to high. Conclusion : In patients with knee OA, improvements in body function, activity, and health-related quality of life can be maintained with exercise programs of >150 days' duration, and these findings are supported by a moderate to high level of evidence.

  The Japanese Association of Rehabilitation Medicine, Dec. 2014, Japanese Journal of Rehabilitation Medicine, 51(11) (11), 724 - 737, Japanese

  [Refereed]

  Scientific journal


• 健常成人男性の股関節屈曲角度における臨床的に意義ある最少差の検討

  赤澤 直紀, 原田 和宏, 大川 直美, 中谷 聖史, 北裏 真己, 松井 有史, 森山 英樹

  Corresponding, Dec. 2014, 運動器リハビリテーション, 25(4) (4), 367 - 373, Japanese

  [Refereed]

  Scientific journal


• Effects of exercise on fiber properties in the denervated rodent diaphragm

  Hidetaka Imagita, Susumu Sakata, Akira Minematsu, Naohiko Kanemura, MORIYAMA HIDEKI, Hidenori Takemoto, Tadayuki Mita

  Nov. 2014, American Journal of Biomedical and Life Sciences, 2(6) (6), 141 - 145, English

  [Refereed]

  Scientific journal


• Effect of the Frequency and Duration of Land-based Therapeutic Exercise on Pain Relief for People with Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Hideki Moriyama

  Last, Jul. 2014, Journal of Physical Therapy Science, 26(7) (7), 969 - 975, English

  [Refereed]

  Scientific journal


• Efficacy of strengthening or aerobic exercise on pain relief in people with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Hideki Moriyama

  Last, Dec. 2013, Clinical Rehabilitation, 27(12) (12), 1059 - 1071, English

  [Refereed]

  Scientific journal


• Amount of Torque and Duration of Stretching Affects Correction of Knee Contracture in a Rat Model of Spinal Cord Injury

  Hideki Moriyama, Yoshiko Tobimatsu, Junya Ozawa, Nobuhiro Kito, Ryo Tanaka

  Nov. 2013, Clinical Orthopaedics and Related Research, 471(11) (11), 3626 - 3636, English

  [Refereed]

  Scientific journal


• Regulation of connective tissue remodeling in the early phase of denervation in a rat skeletal muscle.

  Junya Ozawa, Tomoyuki Kurose, Seiichi Kawamata, Akinori Kaneguchi, Hideki Moriyama, Nobuhiro Kito

  Denervation alters the metabolism of the extracellular matrix (ECM) in skeletal muscle; however, the underlying mechanisms of ECM remodeling are not fully understood. The aim of this study was to elucidate the dynamic features of the ECM regulatory process in the early phase of denervated skeletal muscle in male Wistar rats. We investigated the expression of collagens (total, type I, and type III), transforming growth factor beta 1 (TGF-β1), and matrix metalloproteases (MMPs) together with their endogenous inhibitors (TIMPs), at the mRNA and/or protein level in the soleus muscles of control animals and at days 3, 7, and 14 post-denervation. Expression of mRNA encoding collagens was decreased at days 3 and 7, and had recovered by day 14, in parallel with total collagen protein content. Content of TGF-β1 protein was elevated sequentially, up to a maximum of 158% at day 14 post-denervation (P < 0.05), as was TIMP-2 mRNA expression (272% at day 14), whereas MMP-1, MMP-2, and TIMP-1 mRNA expression was not affected at any stage. The initial reduction of collagen mRNA may be responsible for hypoactivity caused by the disappearance of contractile function. Recovery of collagen mRNA/protein at day 14 may be due mainly to the suppressive effects of TGF-β1 on collagen degradation via TIMP-2 upregulation.

  2013, Biomedical research (Tokyo, Japan), 34(5) (5), 251 - 8, English, Domestic magazine

  [Refereed]

  Scientific journal


• Evidence of improvement in various impairments by exercise interventions in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized clinical trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, Takahiro Yamasaki, Hideki Moriyama

  Last, 日本理学療法士協会, 2013, Journal of the Japanese Physical Therapy Association, 16(1) (1), 7 - 21, English

  [Refereed]

  Scientific journal


• 内側型変形性膝関節症に対する膝外反装具の長期使用による歩行動作への影響

  鳥山 実, 出家 正隆, 島田 昇, 森山 英樹, 折田 直哉, 越智 光夫

  日本臨床バイオメカニクス学会, Dec. 2012, 臨床バイオメカニクス, 33・321-328, 321 - 327, Japanese

  [Refereed]

  Scientific journal


• Effects of aging and exercise training on the histological and mechanical properties of articular structures in knee joints of male rat

  Hideki Moriyama, Naohiko Kanemura, Inge Brouns, Isabel Pintelon, Dirk Adriaensen, Jean-Pierre Timmermans, Junya Ozawa, Nobuhiro Kito, Toshiaki Gomi, Masataka Deie

  Aug. 2012, Biogerontology, 13(4) (4), 369 - 381, English

  [Refereed]

  Scientific journal


• Effects of unloading bracing on knee and hip joints for patients with medial compartment knee osteoarthritis

  Minoru Toriyama, Masataka Deie, Noboru Shimada, Takuya Otani, Hiroe Shidahara, Hiroshi Maejima, Hideki Moriyama, Hayatoshi Shibuya, Atsushi Okuhara, Mitsuo Ochi

  Jun. 2011, Clinical Biomechanics, 26(5) (5), 497 - 503, English

  [Refereed]

  Scientific journal


• ラット足関節軟骨の加齢と運動の影響

  村田 健児, 金村 尚彦, 羽田 侑里子, 飯島 弘貴, 高栁 清美, 森山 英樹

  加齢により関節軟骨は退行性変化を呈し，主要構成要素であるプロテオグリカン含量やⅡ型コラーゲンの減少が認められる。この関節軟骨の退行性変化は運動がもたらす関節への機械的刺激によって抑制および修復させることが報告されている。本研究では老齢ラットモデルの距腿関節軟骨を組織学的に分析し，走行運動およびバランス運動が距腿関節軟骨にあたえる影響を検討した。結果，老齢ラット群の関節軟骨は若齢ラット群と比較してⅡ型コラーゲン及び関節軟骨厚が減少し，関節軟骨表層部に亀裂が認められた。一方で，老齢ラット通常飼育群に比較してバランス運動群の軟骨厚が増加していた。このことから加齢によって距腿関節軟骨退行性変化を呈するが，関節運動を伴う機械的刺激によって関節軟骨変性を抑制，改善に作用する可能性があることが示唆された。

  Corresponding, 公益社団法人 埼玉県理学療法士会, Apr. 2011, 理学療法－臨床・研究・教育, 18(1) (1), 61 - 66, Japanese

  [Refereed]

  Scientific journal


• 運動器疾患に対するストレッチングの効果―システマティックレビューとメタアナリシスによる検討―

  森山 英樹, 増子 潤, 金村 尚彦, 木藤 伸宏, 小澤 淳也, 今北 英高, 高柳 清美, 伊藤 俊一, 磯崎 弘司, 出家 正隆

  (公社)日本理学療法士協会, Feb. 2011, 理学療法学, 38(1) (1), 1 - 9, Japanese

  [Refereed]

  Scientific journal


• Contribution of knee adduction moment impulse to pain and disability in Japanese women with medial knee osteoarthritis

  Nobuhiro Kito, Koichi Shinkoda, Takahiro Yamasaki, Naohiko Kanemura, Masaya Anan, Natsuko Okanishi, Junya Ozawa, Hideki Moriyama

  Last, Nov. 2010, Clinical Biomechanics, 25(9) (9), 914 - 919, English

  [Refereed]

  Scientific journal


• Effect of position of electrodes relative to the innervation zone on surface EMG

  Nishihara K, Chiba Y, Suzuki Y, Moriyama H, Kanemura N, Ito T, Takayanagi K, Gomi T

  Feb. 2010, Journal of medical engineering & technology, 34(2) (2), 141 - 147, English

  [Refereed]

  Scientific journal


• 運動器障害に対する牽引療法の効果

  森山 英樹, 飯島 弘貴, 金村 尚彦, 羽田 侑里子, 村田 健児, 今北 英高, 高柳 清美, 伊藤 俊一, 五味 敏昭, 飛松 好子

  日本運動器科学会, Dec. 2009, 運動療法と物理療法, 20(4) (4), 369 - 378, Japanese

  [Refereed]

  Scientific journal


• 運動器障害に対する温熱療法の効果

  森山 英樹, 飯島 弘貴, 金村 尚彦, 村田 健児, 羽田 侑里子, 西原 賢, 小澤 淳也, 高栁 清美, 五味 敏昭, 飛松 好子

  日本運動器科学会, Nov. 2009, 運動療法と物理療法, 20(3) (3), 260 - 268, Japanese

  [Refereed]

  Scientific journal


• Noninvasive estimation of muscle fiber conduction velocity distribution using an electromyographic processing technique

  Ken Nishihara, Yu Chiba, Hideki Moriyama, Masataka Hosoda, Yosuke Suzuki, Toshiaki Gomi

  Sep. 2009, Medical Science Monitor, 15(9) (9), MT113 - MT120, English

  [Refereed]

  Scientific journal


• Alteration in articular structure of knee joints in the progression of contractures after spinal cord injury

  Hideki Moriyama, Yoshiko Tobimatsu

  Nova Science Publishers, Inc., Apr. 2009, Handbook of Spinal Cord Injuries: Types, Treatments and Prognosis, 397 - 426, English

  In book


• Contrasting alteration patterns of different cartilage plates in knee articular cartilage after spinal cord injury in rats

  H. Moriyama, K. Nishihara, M. Hosoda, Y. Saka, N. Kanemura, K. Takayanagi, O. Yoshimura, Y. Tobimatsu

  Mar. 2009, Spinal Cord, 47(3) (3), 218 - 224, English

  [Refereed]

  Scientific journal


• ラット脊髄損傷後早期の関節拘縮進行過程における筋と関節構成体の関与

  MORIYAMA Hideki, TSUNODA Ikuko, YAE Miwa, SAKA Yukari, TAKEMOTO Hidenori, KAWANO Ichiro, HOSODA Masataka, TAKAYANAGI Kiyomi, ITO Toshikazu, TOBIMATSU Yoshiko

  Introduction: The objective of this study was to determine the rate of contracture progression and the direction of loss in joint movement, and to identify the relationship between the muscular and articular factors leading to contractures in acute spinal cord injuries. Methods: Twenty female Wistar rats were allocated to one of 5 equal sized groups that were assessed respectively at preinjury, 3, 5, 7, or 14 days after spinal cord injuries. The degree of contractures was assessed by measuring the femorotibial angle on both hindlimbs with the use of a goniometer. Knee joint motion was measured for flexion and extension. Myotomy of the transarticular muscles was then performed and range of motion was measured again. Results: The spinal cord-injured animals demonstrated a flaccid paralysis during the first 7 days postinjury and thereafter spastic paralysis. Contractures progressed for 14 days after spinal cord injuries, regardless of changes in muscle tone. Loss in joint movements was produced almost exclusively by a loss in the extension range of motion. Both the muscles and the articular structures contributed to the progression of the contracture, and these components are factors in the promotion of contracture development. In particular, the muscular factors were greater than the articular factors in extension angular displacement in which the range of motion was restricted. Discussion: Based on our findings of contractures in acute spinal cord injuries, in addition to the changes of the articular structures, more attention should be directed to the changes of the muscles.

  Japanese Physical Therapy Association (JPTA), Dec. 2008, 理学療法学, 35(7) (7), 318 - 324, Japanese

  [Refereed]

  Scientific journal


• 多裂筋からの関連痛により腹部・陰部痛を生じた一症例

  鈴木 陽介, 藤縄 理, 須永 康代, 荒木 智子, 森山 英樹

  Jun. 2008, 徒手的理学療法, 7(2) (2), 41 - 44, Japanese

  [Refereed]

  Scientific journal


• ラット脊髄損傷後の膝関節における軟骨細胞数とプロテオグリカン量の組織学的変化

  MORIYAMA HIDEKI, 吉村理, 高栁清美, 小林隆司, 細田昌孝, 金村尚彦, 今北英高, 白濱勲二, 鈴木陽介, 荒木智子, 須永康代, 飛松好子

  専門リハビリテーション研究会, Mar. 2008, 専門リハビリテーション, 7, 34 - 41, Japanese

  [Refereed]

  Scientific journal


• Alteration in articular cartilage of rat knee joints after spinal cord injury

  H. Moriyama, O. Yoshimura, S. Kawamata, K. Takayanagi, T. Kurose, A. Kubota, M. Hosoda, Y. Tobimatsu

  Mar. 2008, Osteoarthritis and Cartilage, 16(3) (3), 392 - 398, English

  [Refereed]

  Scientific journal


• The mRNA expression of neurotrophins in different skeletal muscles of young rats

  Yukari Saka, Osamu Yoshimura, Hidetoshi Tahara, Yayoi Takeda, Hideki Moriyama, Hiroshi Maejima, Yoshiko Tobimatsu

  Dec. 2007, Hiroshima Journal of Medical Sciences, 56(3-4) (3-4), 23 - 28, English

  [Refereed]

  Scientific journal


• The time course and extent of motor neuron loss following spinal cord compression in rats

  Takemoto Hidenori, Yoshimura Osamu, Moriyama Hideki, Imagita Hidetaka, Shirahama Kunji, Kawamata Seiichi, Kajihara Hiroki, Tobimatsu Yoshiko

  Motor deficits after spinal cord injury arise from damages to the descending spinal pathways and ventral motoneurons (VMN). In contrast to data on damages to the white matter or the descending spinal pathways, few quantitative data on damages to VMN after injury are available currently. The purpose of this study was to examine quantitatively the temporal and spatial pattern of VMN loss after spinal cord compression. Two groups of adult female Wistar rats were used in this study: rats which were subjected to spinal cord compression in short duration with an aneurysm clip (experimental group) and rats which were subjected to a sham-operation (control group). Using serial cross-sections of the spinal cord, VMN were counted up to the 7th day after surgical intervention at 0, 1, 2, and 3 mm rostral and caudal to the lesion epicenter (experimental group) or to the median of the serial sections (control group). At 15 minutes after the compression, VMN were lost only at the epicenter section and no VMN were observed there. By 8 hours, VMN loss had spread to next 1 mm rostral and caudal section to the epicenter. Virtually, no further loss was detected between 8 hours and later time points. This study showed that compression to the adult rat spinal cord in short duration led to VMN loss, which progressed acutely and expanded modestly. Our findings could be used to develop effective treatment and provide a better understanding of VMN loss after spinal cord injury.

  広島大学保健学出版会, Sep. 2007, Journal of health sciences, Hiroshima University, 6(2) (2), 111 - 117, English

  [Refereed]

  Research institution


• 高齢者の意欲と生活動作能力の関連

  村上 雅也, 荒川 美穂, 川上 康子, 久保田 章仁, 森山 英樹

  Apr. 2007, 理学療法－臨床・研究・教育, 14(1) (1), 58 - 62, Japanese

  [Refereed]

  Scientific journal


• Standing balance after unexpected disturbance with and without jaw clenching

  M. Hosoda, K. Nishihara, K. Isozaki, K. Takayanagi, H. Moriyama, A. Kubota, K. Inoue, N. Sakanoue, T. Matsuda, K. Shiota, J. Shimizu, R. Yonetsu, S. Morita

  2007, PROCEEDINGS OF THE 4TH WORLD CONGRESS OF THE INTERNATIONAL SOCIETY OF PHYSICAL AND REHABILITATION MEDICINE, 53 - +, English

  [Refereed]

  International conference proceedings


• Computation of muscle fiber conduction velocity by using a newly developed electromyography analysis technique

  K. Nishihara, M. Hosoda, Y. Suzuki, Y. Sunaga, T. Araki, H. Moriyama, A. Kubota, K. Inoue, T. Taguchi, H. Maruoka, Y. Chiba

  2007, PROCEEDINGS OF THE 4TH WORLD CONGRESS OF THE INTERNATIONAL SOCIETY OF PHYSICAL AND REHABILITATION MEDICINE, 81 - 85, English

  [Refereed]

  International conference proceedings


• 健常者における足圧中心点を指標とした静止立位時および立位外乱刺激時の姿勢制御 初期姿勢の違い. 二重課題による影響

  河野一郎, 高杉紳一郎, 岩本幸英, 飛松好子, 前島 洋, 森山英樹, 武本秀徳, 坂 ゆかり, 大谷拓哉

  国立大学理学療法士協議会, 2007, 国立大学法人リハビリテーションコ・メディカル学術大会誌, 28(1) (1), 55 - 57, Japanese

  [Refereed]

  Scientific journal


• Alteration of knee joint connective tissues during contracture formation in spastic rats after an experimentally induced spinal cord injury

  Hideki Moriyama, Osamu Yoshimura, Seiichi Kawamata, Hidenori Takemoto, Yukari Saka, Yoshiko Tobimatsu

  Lead, 2007, Connective Tissue Research, 48(4) (4), 180 - 187, English

  [Refereed]

  Scientific journal


• 和太鼓演奏を種目とした機能訓練事業のストレス及び睡眠に及ぼす影響

  小林 隆司, 白濱 勲二, 森山 英樹, 金村 尚彦

  Jul. 2006, 日本職業・災害医学会会誌, 54(1) (1), 25 - 28, Japanese

  [Refereed]

  Scientific journal


• 片側大腿切断者における足圧中心点を指標とした静止立位時の姿勢制御 ソケットの形状による影響

  河野 一郎, 飛松 好子, 前島 洋, 森山 英樹, 武本 秀徳, 坂 ゆかり, 大谷 拓哉, 高杉 紳一郎, 岩本 幸英

  Apr. 2006, 広島大学保健学ジャーナル, 6(1) (1), 17 - 24, Japanese

  [Refereed]

  Research institution


• Comparison of muscular and articular factors in the progression of contractures after spinal cord injury in rats

  H Moriyama, O Yoshimura, H Sunahori, Y Tobimatsu

  Mar. 2006, Spinal Cord, 44(3) (3), 174 - 181, English

  [Refereed]

  Scientific journal


• ストループテストを用いたパーキンソン病の前頭葉機能評価

  白濱 勲二, 加世田 ゆみ子, 三森 康世, 小林 隆司, 金村 尚彦, 今北 英高, 森山 英樹, 新田 春子, 吉村 理

  Jan. 2006, 神奈川県立保健福祉大学誌, 3(1) (1), 1 - 8, Japanese

  [Refereed]

  Research institution


• 末梢神経切断ラットにおける足趾マイスナー小体の変化 非特異的コリンエステラーゼ染色による検討

  渡邉 誠, 金村 尚彦, 今北 英高, 森山 英樹

  Oct. 2005, 総合リハビリテーション, 33(7) (7), 675 - 678, Japanese

  [Refereed]

  Scientific journal


• 加速度計を用いた下肢振り子試験による痙縮の定量的評価

  大谷 拓哉, 佐々木 久登, 森山 英樹, 松田 祐一, 垣内 秀雅, 吉村 理

  広島県理学療法士会, Jul. 2005, 理学療法の臨床と研究, 14(14) (14), 3 - 6, Japanese

  [Refereed]

  Scientific journal


• 発達過程におけるラット横隔膜の経時的変化

  宮本 英高, 金村 尚彦, 佐々木 久登, 田中 幸子, 白濱 勲二, 森山 英樹, 坂 ゆかり, 堤 恵理子, 前島 洋, 吉村 理

  Apr. 2005, 総合リハビリテーション, 33(1) (1), 65 - 71, Japanese

  [Refereed]

  Scientific journal


• 介護老人保健施設痴呆専門棟における転倒の危険因子

  坂本 望, 森山 英樹, 今北 英高, 前島 洋, 吉村 理, 白濱 勲二

  Oct. 2004, 日本職業・災害医学会会誌, 52(3) (3), 161 - 165, Japanese

  [Refereed]

  Scientific journal


• 神経切断器具の違いが断端神経腫の形成に与える影響について

  坂 ゆかり, 金村 尚彦, 今北 英高, 森山 英樹, 吉村 理

  Sep. 2004, 広島理学療法学, 13, 59 - 62, Japanese

  [Refereed]

  Scientific journal


• Progression and direction of contractures of knee joints following spinal cord injury in the rat

  H Moriyama, O Yoshimura, H Sunahori, H Nitta, H Imakita, Y Saka, H Maejima, Y Tobimatsu

  Sep. 2004, Tohoku Journal of Experimental Medicine, 204(1) (1), 37 - 44, English

  [Refereed]

  Scientific journal


• 脊髄損傷ラットに伴う関節拘縮の進行経過と制限の方向

  森山 英樹, 砂堀 仁志, 堤 恵理子, 渡邉 誠, 金村 尚彦, 小澤 淳也, 白濱 勳二, 吉村 理

  Apr. 2004, 総合リハビリテーション, 32(2) (2), 169 - 174, Japanese

  [Refereed]

  Scientific journal


• ベッド環境が寝返り動作及びその介助動作に与える影響

  前島 洋, 宮腰 由紀子, 松成 裕子, 藤井 宝恵, 森山 英樹, 田中 幸子, 吉村 理

  May 2002, 日本職業・災害医学会会誌, 50(3) (3), 219 - 226, Japanese

  [Refereed]

  Scientific journal


• 高齢大腿骨頸部骨折患者の中臀筋筋電図周波数特性に関する検討

  前島 洋, 佐々木 久登, 田中 幸子, 金村 尚彦, 森山 英樹, 白濱 勲二, 宮本 英高, 吉村 理

  Mar. 2002, 日本職業・災害医学会会誌, 50(2) (2), 107 - 112, Japanese

  [Refereed]

  Scientific journal


• 筋放電休止期と反応時間及びバランス能力との関係 切断者と健常者の比較

  佐々木 久登, 荒井 隆志, 金村 尚彦, 田中 幸子, 白濱 勲二, 宮本 英高, 森山 英樹, 吉村 理, 前島 洋

  Mar. 2002, 日本職業・災害医学会会誌, 50(2) (2), 145 - 151, Japanese

  [Refereed]

  Scientific journal


• 高齢者における身体アライメント変形が立位バランスに与える影響

  森山英樹, 前島 洋, 武石清久, 砂堀仁志, 中島清美, 吉村 理

  2002, 広島転倒予防研究会誌, 2(1) (1), 4 - 7

  [Refereed]

  Scientific journal


• 歩行障害のメカニズムと鑑別診断 痙性対麻痺歩行障害

  吉村 理, 前島 洋, 金村尚彦, 森山英樹, 坂田 清

  2002, 日本義肢装具学会誌, 18(1) (1), 997 - 1002

  Scientific journal


• Changes of mechanoreceptor in anterior cruciate ligament with hindlimb suspension rats

  Naohiko Kanemura, Ryuji Kobayashi, Hiroki Kajihara, Akira Minematu, Hisato Sasaki, Sachiko Tanaka, Kunji Shirahama, Hidetaka Miyamoto, Makoto Watanabe, Kaori Yata, Hideki Moriyama, Hiroshi Maejima, Osamu Yoshimura

  Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai), 2002, Journal of Physical Therapy Science, 14(1) (1), 27 - 32, English

  [Refereed]

  Scientific journal


• Possibility of Independence in ADL for Patients with Cervical Spinal Cord Injuries-An Evaluation based on the Modified Zancolli Classification

  吉村 理, 前島 洋, 小林 隆司, 峯松 亮, 佐々木 久登, 田中 幸子, 金村 尚彦, 白濱 勲二, 上田 健人, 上田 千絵, 渡辺 誠, 矢田 かおり, 宮本 英高, 森山 英樹, 加藤 浩, 河元 岩男

  頚髄損傷の評価では,頚髄の損傷の程度と損傷高位が重要である.米国脊髄損傷協会は,脊髄損傷の障害の評価法を発表し,脊髄損傷の神経学的および機能的分類のための国際基準として現在国際的に使用されている.しかし可能性に挑戦するリハビリテーションとしては,より詳細な高位分類が必要である.Zancolli分類は頚髄損傷四肢麻痺の上肢機能を細かく分類し,リハビリテーションからみても車椅子ADLが自立する可能性のあるC6を細かく分けているのは有用である.しかしマット上基本動作,移乗・移動などの動作が自立するか否かの判断に重要な肩甲帯筋群の評価がない.従来肘伸展筋である上腕三頭筋はC7髄節筋であるが,Zancolli分類ではC6髄節残存群のサブグループとしているのは混乱をまねく.そこでZancolli分類を改良し,損傷高位別の機能到達目標を決定するための評価表を作成し,ADLが自立する可能性について検討した.改良Zancolli分類でみるとC6BⅡが車椅子ADL自立の境界レベルである.

  広島大学大学院保健学研究科, Aug. 2001, Journal of health sciences, Hiroshima University, 1(1) (1), 73 - 77, Japanese

  [Refereed]

  Research institution


• Bowel dysfunction and disturbance of physical condition after evacuation in patients with chronic cervical spinal cord injuries

  Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi

  Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai), 2001, Journal of Physical Therapy Science, 13(2) (2), 145 - 148, English

  [Refereed]

  Scientific journal


• Muscular Power of Truncal Extension and Flexion in Patients with HAM.

  YOSHIDA Yoshihiro, SHIMIZU Shun-ichiro, MORIYAMA Hideki, UENO Kayoko, YAMAGUCHI Naomi, OSAME Mitsuhiro

  Human T-Lymphotrophic virus Type-I (HTLV-I) associated myelopathy (HAM/TSP), which manifests as paraplegia is a common disease in Kagoshima prefecture. For planning the rehabilitation of these patients, we determined their muscular power of truncal flexion and extension as posture-supporting muscles in eccentric and concentric contraction with KINCOM 5000, and compared the results with those of healthy controls. Muscular strength of truncal extension in those with HAM was significantly decreased; however, that of truncal flexion was not decreased when it was compared to that of healthy controls. These results indicate that the decreased muscular power of truncal extension in patients with HAM is a characteristic. The mechanism is still unknown. Patients with HAM usually use canes and support their body weight with the non-impaired upper extremities, which may have resulted in the sparing of the muscular power of truncal flexion. There is an alternative possibility that spasticity observed in truncal muscles in patients with HAM is related to this.

  The Japanese Association of Rehabilitation Medicine, Aug. 2000, The Japanese Journal of Rehabilitation Medicine, 37(3) (3), 175 - 177, Japanese

  [Refereed]

  Scientific journal

• 文献収集と管理 実践編 Google Scholar

  森山英樹

  Lead, Aug. 2025, 理学療法ジャーナル, 59(8) (8), 990 - 993, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 実践編 CiNii Research

  森山英樹

  Lead, Jul. 2025, 理学療法ジャーナル, 59(7) (7), 857 - 860, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 実践編 医中誌Web

  森山英樹

  Lead, Jun. 2025, 理学療法ジャーナル, 59(7) (7), 729 - 733, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 実践編 PubMed

  森山英樹

  Lead, May 2025, 理学療法ジャーナル, 59(5) (5), 608 - 613, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 基礎編 研究の評価指標

  森山英樹

  Lead, Apr. 2025, 理学療法ジャーナル, 59(4) (4), 479 - 482, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 基礎編 診療ガイドライン

  森山英樹

  Lead, Mar. 2025, 理学療法ジャーナル, 59(3) (3), 355 - 359, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 基礎編 文献データベース

  森山英樹

  Lead, Feb. 2025, 理学療法ジャーナル, 59(2) (2), 227 - 230, Japanese

  [Invited]

  Introduction commerce magazine


• 文献収集と管理 基礎編 文献の種類とエビデンスのレベル

  森山英樹

  Lead, Jan. 2025, 理学療法ジャーナル, 59(1) (1), 103 - 106, Japanese

  [Invited]

  Introduction commerce magazine


• システマティックレビューとメタアナリシス

  森山英樹, 高村大祐, 井上翔太

  Lead, Jul. 2023, 理学療法ジャーナル, 57(7) (7), 837 - 840, Japanese

  [Invited]

  Introduction commerce magazine


• 文献検索

  森山英樹, 井上翔太, 高村大祐

  Lead, Jun. 2023, 理学療法ジャーナル, 57(6) (6), 720 - 721, Japanese

  [Invited]

  Introduction commerce magazine


• メカニカルストレスの影響

  森山英樹, 井上翔太, 脇本祥夫, 高村大祐

  Lead, Jan. 2022, 理学療法ジャーナル, 56(1) (1), 90 - 94, Japanese

  [Invited]


• 「運動神経」とは何か

  森山英樹, 井上翔太

  Lead, Jun. 2020, Clinical Neuroscience, 38(6) (6), 701 - 704, Japanese

  [Invited]

  Introduction commerce magazine


• 研究へのいざない

  森山 英樹

  Mar. 2019, 専門リハビリテーション, 18, 61 - 65, Japanese

  [Invited]

  Introduction scientific journal


• 変形性膝関節症に対する運動療法

  木藤 伸宏, 小澤 淳也, 森山 英樹

  Feb. 2019, ペインクリニック, 40(2) (2), 166 - 176, Japanese

  [Invited]

  Introduction commerce magazine


• 脊柱と下肢の運動連鎖

  木藤伸宏, 阿南雅也, 小澤淳也, 森山英樹

  Sep. 2018, 理学療法, 35(8) (8), 703 - 713, Japanese

  [Invited]

  Introduction commerce magazine


• 変形性膝関節症に対する保存療法の変遷

  木藤 伸宏, 小澤 淳也, 森山 英樹, 徳田 一貫, 澤田 智紀, 阿南 雅也

  Apr. 2018, 理学療法ジャーナル, 52(4) (4), 287 - 300, Japanese

  [Invited]

  Introduction commerce magazine


• 基礎研究からみたエビデンス－理学療法におけるこれからの基礎研究のあり方－

  森山 英樹

  Oct. 2017, 理学療法学, 44(Suppl.3) (Suppl.3), 38 - 39, Japanese

  [Invited]

  Introduction scientific journal


• 運動が関節におよぼす影響

  MORIYAMA HIDEKI

  Jan. 2017, Clinical Calcium, 27(1) (1), 87 - 94, Japanese

  [Invited]

  Introduction scientific journal


• 症例から学ぶ理学療法士の人体解剖図実習 変形膝性関節症

  MORIYAMA HIDEKI, 三木 明徳

  Jan. 2015, 理学療法magazine, 2(1) (1), 72 - 79, Japanese

  [Invited]

  Introduction commerce magazine


• 変形性膝関節症とメカニカルストレス 基礎研究の視点から

  森山 英樹

  Feb. 2014, 近畿理学療法学術大会誌, 43, CD03_001, Japanese

  [Invited]

  Introduction scientific journal


• これからの筋力トレーニングのあり方―変形性膝関節症に対する筋力トレーニングのあり方―

  木藤 伸宏, 小澤 淳也, 金口 瑛典, 田中 亮, 阿南 雅也, 金村 尚彦, 森山 英樹, 新小田 幸一

  Sep. 2013, 理学療法, 30(9) (9), 999 - 1009, Japanese

  [Invited]

  Introduction commerce magazine


• 変形性関節症の生物学

  MORIYAMA HIDEKI

  Mar. 2013, 近畿理学療法学術大会誌, 42, CD03_006, Japanese

  [Invited]

  Introduction scientific journal


• 切断術後の断端管理

  前島 洋, 佐々木 久登, 森山 英樹, 金村 尚彦, 白濱 勲二, 宮本 英高, 吉村 理

  Jun. 2012, 日本義肢装具学会誌, 18(1) (1), 25 - 27, Japanese

  [Invited]

  Introduction scientific journal


• Investigating joint contractures following central nervous system injury : through comparison with contractures following joint immobilization

  斎藤 勇貴, 武本 秀徳, 森山 英樹, 山口 希菜, 沖 貞明, 小野 武也, 梅井 凡子, 大塚 彰

  近年，動物モデルの分析を通じて，関節固定そして中枢神経障害にともなう関節拘縮はそれぞれ区別されるべきとの根拠が提示されるようになってきた。これまでに得られた結果は（1）原因が異なると，関節拘縮の進行に筋と関節構成体のそれぞれが関与する割合は異なる，（2）滑膜に生じる病理変化は中枢神経障害モデルの変化の方がより多面的である，（3）原因が異なると，関節軟骨の厚さに異なる変化が異なる分布で発生する，と要約できる。現時点では治療法は区別されていないが，こうした知見は原因別に最適化された治療アプローチが必要であることを示している。これまで各種治療の関節可動域の治療効果は，主に関節固定モデルを用いて検証されてきた。そこで得られた情報は，中枢神経障害における関節拘縮の治療でも利用できる可能性がある。しかし，病態は同一ではないため，治療による可動域，そして組織への効果は，原因ごとに検討される必要がある。Analyzing experimental animal tests, there is growing evidence demonstrating that respective contractures following joint immobilization and central nervous system（CNS）injury should be distinguished. Results from the tests could be summarized as follows:（1）roles of muscular and articular factors in the progression of contractures are different causedependently, (2）pathological changes in synovial membrane are more complex in contractures following CNS injury,（3）depending on the cause of contractures, differences in articular cartilage thickness appear in different manners and locations. These findings indicate that differing optimized therapeutic approaches are required cause-dependently, whereas such a distinction is not made at present. To date, the effect of therapeutic strategies on joint range of motion has been studied using experimental joint immobilization models mainly. Information from these studies could be used to treat contractures following CNS injury. However, therapeutic effects on joint motion, morphology and physiology should be tested for joint immobilization and CNS injury models, respectively, because differences are seen in pathology.総説General Article

  県立広島大学, Mar. 2012, 人間と科学 県立広島大学保健福祉学部誌, 12(1) (1), 9 - 15, Japanese

  [Invited]

  Introduction research institution


• 非特異的腰痛の理学療法 非特異的腰痛に対する理学療法

  伊藤 俊一, 隈元 康夫, 森山 英樹, 白土 修

  Nov. 2011, 理学療法, 28(11) (11), 1333 - 1338, Japanese

  [Invited]

  Introduction commerce magazine


• 大腿骨頸部骨折後の運動療法に関するシステマティックレビュー

  松田 雅弘, 小山 貴之, 塩田 琴美, 森山 英樹, 金村 尚彦, 磯崎 弘司

  Aug. 2011, 理学療法学, 38(8) (8), 633 - 636, Japanese

  [Invited]

  Introduction scientific journal


• ラット膝前十字靭帯新鮮損傷の保存療法モデルの組織学的検討

  国分貴徳, 金村尚彦, 森山英樹, 島村亮太, 井原秀俊, 高柳清美

  2011, 理学療法学, 38, ROMBUNNO.PI1-322, Japanese


• 変形性膝関節症の運動療法に関するシステマティックレビュー

  小澤 淳也, 木藤 伸宏, 森山 英樹, 金村 尚彦, 田中 亮

  May 2010, 理学療法学, 26(5) (5), 589 - 594, Japanese

  [Invited]

  Introduction scientific journal


• 理学療法効果を検証するためのシステマティックレビューの作成方法と実践

  MORIYAMA HIDEKI

  May 2010, 理学療法学, 26(5) (5), 585 - 588, Japanese

  [Invited]

  Introduction scientific journal


• 健康寿命の延伸と骨・関節に対する理学療法

  森山 英樹, 伊藤 俊一, 金村 尚彦, 小澤 淳也, 高栁 清美, 出家 正隆

  Apr. 2010, 理学療法, 27(4) (4), 527 - 533, Japanese

  [Invited]

  Introduction commerce magazine


• 慢性腰痛症者に対するセルフエクササイズ

  伊藤 俊一, 隈元 康夫, 久保田 健太, 森山 英樹, 菊本 東陽

  Jan. 2010, 臨床整形外科, 45(1) (1), 21 - 28, Japanese

  [Invited]

  Introduction scientific journal


• Effect of post contracted muscle stretching for chronic low back pain

  ITO Toshikazu

  Examining the effect of muscle stretching and self-training (hospital-prescribed method) for chronic lower-back pain. The maximum treatment period in the survey was 3 months since the previous outpatient consultation. The test group was divided into three: a control group, Exercise 1 group (carrying out SLR with trunk muscle contract relaxation), and Exercise 2 group (carrying out SLR with trunk muscle strengthening and lower back stretching).
  For each group, the pain, change of physical function and health-related QOL were examined at 3 months and 6 months after the start of the research period.
  The results showed that in the Exercise 2 group, pain and physical function was improved at 3 months; in the Exercise 1 group, almost the same effect was shown as in the Exercise 2 group at 6 months. The item which was most closely related to pain alleviation was trunk flexibility and trunk extension strength.
  In conclusion, for outpatients suffering chronic lower-back pain, follow-up treatment which gives precedence to trunk muscle strengthening and flexibility improvement through self-training would be an effective means of alleviating pain and improving physical function and patient satisfaction.

  The Japanese Society of Lumbar Spine Disorders, Oct. 2009, The Journal of Japanese Society of Lumber Spine Disorders, 15(1) (1), 45 - 51, Japanese

  [Invited]

  Introduction scientific journal


• 重力と理学療法 重力と運動療法

  金村 尚彦, 小林 隆司, 木藤 伸宏, 森山 英樹, 鈴木 陽介, 木戸 聡史, 高栁 清美

  May 2009, 理学療法, 26(5) (5), 597 - 603, Japanese

  [Invited]

  Introduction commerce magazine


• システマティックレビューを行うためのデータベースと活用方法の紹介

  金村 尚彦, 森山 英樹, 高栁 清美

  Mar. 2009, 専門リハビリテーション, 8, 16 - 19, Japanese

  [Invited]

  Introduction scientific journal


• 大腿骨頸部骨折に対するリハビリテーション効果

  細田 昌孝, 松田 雅弘, 森山 英樹, 西原 賢, 高梨 晃, 宮島 恵樹, 塩田 琴美, 高栁 清美

  Mar. 2009, 専門リハビリテーション, 8, 8 - 11, Japanese

  [Invited]

  Introduction scientific journal


• 実践 拘縮予防 寝たきり患者を作らないために 関節可動域運動の実際

  金村 尚彦, 森山 英樹, 奥村 晃司, 木藤 伸宏

  Sep. 2008, リハビリナース, 1(5) (5), 464 - 473, Japanese

  [Invited]

  Introduction commerce magazine


• 運動器疾患理学療法のシステマティックレビュー 膝靱帯損傷治療における理学療法のシステマティックレビュー

  高栁 清美, 細田 昌孝, 久保田 章仁, 森山 英樹, 盆子原 秀三

  Sep. 2006, 理学療法, 23(6) (6), 929 - 937, Japanese

  [Invited]

  Introduction commerce magazine


• 脊椎脊髄損傷 診断・治療・リハビリテーションの最前線 慢性期の治療 異所性骨化に対する処置

  吉村 理, 前島 洋, 白濱 勲二, 宮本 英高, 森山 英樹, 霜井 哲美, 武本 秀徳, 砂堀 仁志

  Apr. 2003, 脊椎脊髄ジャーナル, 16(4) (4), 511 - 515, Japanese

  [Invited]

  Introduction scientific journal


• 歩行障害のメカニズムと鑑別診断 痙性対麻痺性歩行障害

  吉村 理, 前島 洋, 金村 尚彦, 森山 英樹, 坂田 清

  Oct. 2002, 脊椎脊髄ジャーナル, 15(10) (10), 997 - 1002, Japanese

  [Invited]

  Introduction scientific journal


• 幻肢における最新の治療法と研究

  白濱 勲二, 小林 隆司, 佐々木 久登, 田中 幸子, 金村 尚彦, 宮本 英高, 森山 英樹, 峯松 亮, 前島 洋, 吉村 理

  Jun. 2002, 日本義肢装具学会誌, 18(1) (1), 62 - 66, Japanese

  [Invited]

  Introduction scientific journal


• 糖尿病足

  吉村 理, 前島 洋, 佐々木 久登, 金村 尚彦, 白濱 勲二, 宮本 英高, 森山 英樹

  Jun. 2002, 日本義肢装具学会誌, 18(1) (1), 28 - 31, Japanese

  [Invited]

  Introduction scientific journal


• Postoperative management of the stump

  MAEJIMA Hiroshi, SASAKI Hisato, MORIYAMA Hideki, KANEMURA Naohiko, SHIRAHAMA Kunji, MIYAMOTO Hidetaka, YOSHIMURA Osamu

  01 Jan. 2002, 日本義肢装具学会誌 = Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development, 18(1) (1), 25 - 27, Japanese

• 理学療法評価学・実習

  森山英樹

  Editor, 中山書店, Apr. 2023, ISBN: 9784521750088


• 基礎科学を融合した理学療法推論の実際

  森山英樹

  Contributor, 理学療法に活かせる基礎理学療法研究のあり方, 運動と医学の出版社, Apr. 2022


• 最新理学療法学講座 運動器理学療法学

  森山英樹

  Contributor, 2 運動器の基礎理論／筋の病態と損傷，修復／骨の病態と損傷，修復, 医歯薬出版株式会社, Dec. 2021


• 明日の運動療法を磨く理学療法プラクティス こだわり抜く関節可動域運動

  森山英樹

  Contributor, ミニレクチャー 関節拘縮はなぜ起きるのか？, 文光堂, Aug. 2021


• シンプル理学療法学シリーズ 運動器障害理学療法学テキスト 改訂第3版

  高柳清美, 中川法一, 木藤伸宏, 森山英樹

  Editor, 南江堂, Aug. 2021


• Crosslink 理学療法テキスト 運動器障害理学療法学

  森山英樹

  Contributor, 第2章 各論 3 膝・下腿骨骨折, 症例集 膝・下腿骨骨折, メジカルビュー社, Dec. 2020


• Crosslink 理学療法テキスト 日常生活活動学

  森山 英樹

  Contributor, 第6章 代表的な疾患・障害における日常生活活動 3 関節リウマチ 4 変形性関節症（人工関節置換術後を含む）, 症例集 変形性関節症, メジカルビュー社, Feb. 2020


• 移動と歩行－生命とリハビリテーションの根源となるミクロ・マクロ的視座から

  奈良勲, 高橋哲也, 浅井仁, 森山英樹

  Joint editor, 医学書院, Jan. 2020


• 理学療法エビデンス大事典 現場で使える実践ガイド

  森山 英樹

  Supervisor, 西村書店, Jul. 2019


• 理学療法概論 第7版

  臼田 滋, 森山 英樹

  Contributor, 理学療法の学問的体系化と研究法, 医歯薬出版株式会社, Mar. 2019, Japanese


• 理学療法管理学

  森山 英樹, 井澤 和大

  Contributor, 疾患別のリスクマネジメント, 医歯薬出版株式会社, Dec. 2018


• 解剖学・生理学・運動学に基づく動作分析

  MORIYAMA HIDEKI

  Contributor, 運動器疾患の基礎科学的病態を診る, 医歯薬出版株式会社, Jan. 2018, Japanese

  Scholarly book


• シンプル理学療法学シリーズ 理学療法評価学テキスト 改訂第2版

  MORIYAMA HIDEKI

  Contributor, 運動器系疾患 膝関節疾患, 南江堂, Mar. 2017, Japanese

  Textbook


• シンプル理学療法学シリーズ 運動器障害理学療法学テキスト 改訂第2版

  MORIYAMA HIDEKI

  Contributor, 運動器障害理学療法におけるエビデンス, 南江堂, Apr. 2016, Japanese

  Textbook


• 運動器疾患の病態と理学療法

  奈良 勲, 森山 英樹, 木藤 伸宏

  Joint editor, 医歯薬出版株式会社, Dec. 2015, Japanese

  Scholarly book


• 実学としての理学療法概観

  奈良 勲, 木村 勉, 森山 英樹

  Joint editor, 文光堂, Nov. 2015, Japanese

  Scholarly book


• 15レクチャーシリーズ 理学療法テキスト 臨床運動学（変形性股関節症・膝関節症の術前・術後の姿勢・動作の特徴と分析）

  MORIYAMA HIDEKI

  Contributor, 変形性股関節症・膝関節症の術前・術後の姿勢・動作の特徴と分析, 中山書店, Sep. 2015, Japanese

  Textbook


• 今日の理学療法指針

  MORIYAMA HIDEKI

  Contributor, 膝関節～下腿部の骨折, 医学書院, Jun. 2015, Japanese

  Textbook


• シンプル理学療法学・作業療法学シリーズ 運動器系解剖学テキスト

  MORIYAMA HIDEKI

  Contributor, 解剖学各論 骨格系, 南江堂, Mar. 2015, Japanese

  Textbook


• 図解 理学療法技術ガイド 第4版

  MORIYAMA HIDEKI

  Contributor, 頚椎症性脊髄症, 文光堂, Dec. 2014, Japanese

  Textbook


• 理学療法から診る廃用症候群－基礎・予防・介入

  MORIYAMA HIDEKI

  Contributor, 脊髄損傷の廃用症候群, 文光堂, May 2014, Japanese

  Scholarly book


• 理学療法研究の進めかた－基礎から学ぶ研究のすべて

  MORIYAMA HIDEKI

  Editor, 文光堂, Mar. 2014, Japanese

  Scholarly book


• 15レクチャーシリーズ 理学療法テキスト 理学療法評価学Ⅱ

  MORIYAMA HIDEKI

  Editor, 中山書店, Oct. 2013, Japanese

  Textbook


• 15レクチャーシリーズ 理学療法テキスト 理学療法評価学Ⅰ

  MORIYAMA HIDEKI

  Editor, 中山書店, Oct. 2013, Japanese

  Textbook


• 理学療法評価学テキスト

  MORIYAMA HIDEKI

  Contributor, 運動器疾患 下肢, 南江堂, 2010, Japanese, ISBN: 9784524243082

  Textbook


• 理学療法フィールドノート ; 2 運動器疾患

  MORIYAMA HIDEKI

  Contributor, スポーツ活動による前十字靱帯損傷に対して靱帯再建術を行った17歳女性に対する理学療法, 南江堂, 2008, Japanese, ISBN: 9784524243525

  Textbook


• マリガンのマニュアルセラピー

  MORIYAMA HIDEKI

  Contributor, 協同医書出版社, 2007, Japanese, ISBN: 9784763910516

  Textbook

• 成長期における関節へのメカニカルストレスの違いが大腿骨形態に及ぼす影響

  小澤淳也, 森山英樹

  第36回日本運動器科学会, Jul. 2025, Japanese

  Oral presentation


• Effects of exercise on behavioral rhythms and mental health in mice with circadian rhythm disorders

  He C., Wakayama M., Hatakeyama J., Jiang H., Moriyama H.

  World Physiotherapy Congress 2025, May 2025, English

  Oral presentation


• Effects of peripheral magnetic stimulation on bone healing after fractures in mice

  Liu B., Hatakeyama J., Jiang H., Zhang Y., Liu P., Chen Y., Zhao T., Nakahara R., Ito A., Moriyama H.

  World Physiotherapy Congress 2025, May 2025, English

  Poster presentation


• Preventive effects of abdominal ultrasound stimulation on cognitive decline in aging mice

  Jiang H., Liu P., Zhao T., He C., Hatakeyama J., Liu B., Zhang Y., Chen Y., Ai W., Takamura D., Moriyama H.

  World Physiotherapy Congress 2025, May 2025, English

  Poster presentation


• 腹部超音波刺激による老化モデルマウスの認知機能低下に対する予防効果の検証

  姜函林, 劉芃, 趙廷睿, 何春暁, 畠山隼平, 劉斌, 鄧雪虓, 陳雨欣, 艾婉琳, 張逸帆, 若山将弘, 横井諒, 蘇展, 張珂, 森山英樹

  第29回日本基礎理学療法学会学術大会, Oct. 2024, Japanese

  Oral presentation


• 末梢磁気刺激はマウス閉鎖性横断骨折の治癒を促進する

  劉斌, 畠山隼平, 姜函林, 張逸帆, 若山将弘, 劉芃, 陳雨欣, 趙廷睿, 中原崚, 伊藤明良, 森山英樹

  第29回日本基礎理学療法学会学術大会, Oct. 2024, Japanese

  Oral presentation


• 抗炎症作用に着目した大腿四頭筋への末梢磁気刺激による最適な周波数の検証

  張逸帆, 劉芃, 畠山隼平, 横井諒, 劉斌, 若山将弘, 姜函林, 蘇展, 趙廷睿, 森山英樹

  第29回日本基礎理学療法学会学術大会, Oct. 2024, Japanese

  Oral presentation


• 異なる強度の有酸素運動が認知機能に及ぼす影響

  何春暁, 蘇展, 姜函林, 趙廷睿, 横井諒, 若山将弘, 畠山隼平, 森山英樹

  第29回日本基礎理学療法学会学術大会, Oct. 2024, Japanese

  Poster presentation


• パーキンソン病患者の歩行開始動作における予測的姿勢調節に対する足関節背屈トレーニングの効果

  永井厚志, 沖西正圭, 上月強史, 尾畠康太, 高崎翔馬, 児嶋大哲, 丸本浩平, 森山英樹

  第22回日本神経理学療法学会学術大会, Sep. 2024, Japanese

  Oral presentation


• 基礎研究での知識の臨床実践への活用と展望

  森山英樹

  第37回和歌山県理学療法学術大会, Jul. 2024, Japanese

  [Invited]

  Invited oral presentation


• 新規運動模倣薬のマウス骨格筋および骨の廃用症候群に対する予防効果

  横井諒, 井上翔太, 畠山隼平, 姜函林, 若山将弘, 米田遥香, 何春暁, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Oral presentation


• 超音波は機械感受性イオンチャネルPiezo1を介して骨形成を促進する

  井上翔太, 李昌欣, 畠山隼平, 姜函林, 若山将弘, 横井諒, 劉武, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Oral presentation


• 定期的な運動が概日リズム障害における行動リズムとメンタルヘルスに及ぼす影響

  若山将弘, 井上翔太, 畠山隼平, 姜函林, 江口大輔, 横井諒, 米田遥香, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Oral presentation


• 運動模倣薬と運動の併用がマウスの運動機能と骨格筋に与える効果

  米田遥香, 井上翔太, 畠山隼平, 若山将弘, 姜函林, 横井諒, 何春暁, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Oral presentation


• 新規運動模倣薬の変形性膝関節症の予防効果

  何春暁, 井上翔太, 横井諒, 若山将弘, 姜函林, 畠山隼平, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Poster presentation


• 末梢磁気刺激によるマウス閉鎖性横断骨折の治療効果の検証

  劉斌, 井上翔太, 畠山隼平, 李昌欣, 姜函林, 若山将弘, 江口大輔, 鄧雪虓, 劉芃, 森山英樹

  第28回日本基礎理学療法学会学術大会, Dec. 2023, Japanese

  Poster presentation


• 障害者の支援機器開発においてOTがモニター評価に参加する際の業務に対する影響

  内田智子, 石井豊恵, 森山英樹, 二瓶美里

  第57回日本作業療法学会, Nov. 2023, Japanese

  Poster presentation


• オステオカルシンは有酸素運動と筋力増強運動による骨格筋の機能向上・適応に関与する

  畠山隼平, 井上翔太, 李昌欣, 姜函林, 若山将弘, 森山英樹

  第11回日本運動器理学療法学会学術大会, Oct. 2023, Japanese

  Poster presentation


• 物理的刺激を活用した骨折・骨粗鬆症の新たな治療法の非臨床試験

  井上翔太

  第11回日本運動器理学療法学会学術大会, Oct. 2023, Japanese

  Public symposium


• レジスタンストレーニングにおける運動負荷量を決定するための新たな客観的指標の開発

  髙村大祐, 井上翔太, 畠山隼平, 岩田健太郎, 森山英樹

  第11回日本運動器理学療法学会学術大会, Oct. 2023, Japanese

  Oral presentation


• 運動器理学療法領域における基礎研究のあり方を考える

  森山英樹

  第11回日本運動器理学療法学会学術大会, Oct. 2023, Japanese

  Nominated symposium


• 筋力増強運動は抗加齢効果を有するのか：長寿関連タンパク質とテロメア長に着目して

  姜函林, 井上翔太, 李昌欣, 畠山隼平, 若山将弘, 高村大祐, 江口大輔, 森山英樹

  第33回日本老年学会総会, Jun. 2023

  Poster presentation


• 有酸素運動と筋力増強運動がマウス骨格筋におけるマイオカインに与える影響

  畠山隼平, 井上翔太, 李昌欣, 姜函林, 江口大輔, 若山将弘, 森山英樹

  第27回日本基礎理学療法学会学術大会, Oct. 2022, Japanese

  Oral presentation


• 異なる強度の運動が認知機能および海馬成体神経新生とシナプス可塑性に与える影響

  姜函林, 木村優介, 井上翔太, 李昌欣, 畠山隼平, 脇本祥夫, 高村大祐, 森山英樹

  第27回日本基礎理学療法学会学術大会, Oct. 2022, Japanese

  Oral presentation


• マウスの変形性関節症に対する昇り坂および降り坂トレッドミル運動の影響

  李昌欣, 井上翔太, 畠山隼平, 脇本祥夫, 姜函林, 高村大祐, 森山英樹

  第27回日本基礎理学療法学会学術大会, Oct. 2022, Japanese

  Poster presentation


• 網羅的miRNA発現解析による適度な運動量の指標となる血中miRNAバイオマーカーの同定

  江口大輔, 井上翔太, 高村大祐, 畠山隼平, 若山将弘, 小野匡祐, 森山英樹

  第27回日本基礎理学療法学会学術大会, Oct. 2022, Japanese

  Poster presentation


• 低出力超音波パルスよりも高強度の超音波刺激は内軟骨性骨化を促進する－マウス脆弱性骨折モデルを用いた検討－

  井上翔太, 李昌欣, 畠山隼平, 姜函林, 黒木裕士, 森山英樹

  第27回日本基礎理学療法学会学術大会, Oct. 2022, Japanese

  Oral presentation


• 成長期ラットの後肢懸垂が膝関節形成過程に及ぼす影響－膝関節マルアライメントおよび膝蓋大腿関節組織学的変化に着目して－

  小澤淳也, 池田愛理, 金口瑛典, 森山英樹

  第33回日本運動器科学会, Jul. 2022, Japanese

  Oral presentation


• ゲイトトレーナーを用いた歩行練習によりすくみ足と歩行非対称性が改善したパーキンソン病患者の一症例

  永井厚志, 沖西正圭, 上月強史, 尾畠康太, 高崎翔馬, 丸本浩平, 森山英樹

  第61回近畿理学療法学術大会, Jan. 2022, Japanese

  Oral presentation


• 運動器理学療法の可能性を拓く

  森山英樹

  第61回近畿理学療法学術大会, Jan. 2022, Japanese

  Nominated symposium


• パーキンソン病患者の歩行開始動作における予測的姿勢調節と1歩目の一致率の関連について

  永井厚志, 尾畠康太, 高崎翔馬, 丸本浩平, 森山英樹

  第19回日本神経理学療法学会学術大会, Dec. 2021, Japanese

  Poster presentation


• 異なる強度の長期トレッドミル走行運動がマウス脛骨に与える影響

  畠山隼平, 井上翔太, 脇本祥夫, 李昌欣, 木村優介, 姜函林, 黒木裕士, 森山英樹

  第26回日本基礎理学療法学会学術大会, Oct. 2021, Japanese

  Oral presentation


• PTH製剤の低頻度投与と運動負荷が加齢性骨粗鬆症マウスの骨形成に及ぼす影響

  大久保敦子, 井上翔太, 森山英樹

  第122回理学療法科学学会学術大会, Oct. 2021, Japanese

  Oral presentation


• 物理療法によるメカニカルストレスを活用した新たな骨折・骨粗鬆症治療法の開発

  井上翔太, 畠山隼平, 青木仁, 黒木裕士, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐, 秋末敏宏, 森山英樹

  第60回日本生体医工学会大会・第36回日本生体磁気学会大会, Jun. 2021, Japanese

  Nominated symposium


• Environmental enrichment improves motor coordination and increases brain weight in healthy young mice

  Inoue S, Wakimoto Y, Li C, Hatakeyama J, Takamura D, Wakigawa T, Tsubaki T, Kinoshita S, Tajika R, Kimura Y, Akisue T, Moriyama H

  Virtual ISPRM 2021 Congress, Jun. 2021, English

  Poster presentation


• Effects of treadmill running exercise with different intensities on trabecular bone in growing mice

  Hatakeyama J, Inoue S, Wakimoto Y, Li C, Wakigawa T, Tsubaki T, Kinoshita S, Kimura Y, Akisue T, Moriyama H

  Virtual ISPRM 2021 Congress, Jun. 2021, English

  Poster presentation


• Transcutaneous carbon dioxide improves inflammation in rat osteoarthritis

  Li C, Wakimoto Y, Inoue S, Hatakeyama J, Takamura D, Wakigawa T, Tsubaki T, Kinoshita S, Tajika R, Kimura Y, Sakai Y, Akisue T, Moriyama H

  Virtual ISPRM 2021 Congress, Jun. 2021, English

  Poster presentation


• Identifying the preoperative cut-off value of muscle strength for predicting good walking ability after total knee arthroplasty

  Takamura D, Iwata K, Shimogai T, Nishihara H, Moriyama H

  Virtual ISPRM 2021 Congress, Jun. 2021, English

  Poster presentation


• Skeletal muscle response to resistance training with different intensity in mice

  Kimura Y, Wakigawa T, Wakimoto Y, Inoue S, Li C, Hatakeyama J, Takamura D, Tsubaki T, Kinoshita S, Tajika R, Akisue T, Moriyama H

  Virtual ISPRM 2021 Congress, Jun. 2021, English

  Poster presentation


• パーキンソン病患者の歩行開始動作における予測的姿勢調節の変動性とすくみ足の関連

  永井厚志, 沖西正圭, 尾畠康太, 丸本浩平, 森山英樹

  第14回パーキンソン病・運動障害疾患コングレス, Feb. 2021, Japanese

  Poster presentation


• ラット変形性膝関節症に対する経皮的炭酸ガス療法の効果

  李昌欣, 脇本祥夫, 井上翔太, 畠山隼平, 脇川大誠, 椿俊哉, 木下沙英, 酒井良忠, 秋末敏宏, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• 脆弱性骨折に対する拡散型体外衝撃波および高強度超音波の治療効果－ラット大腿骨欠損モデルを用いた検討－

  井上翔太, 脇本祥夫, 李昌欣, 畠山隼平, 脇川大誠, 椿俊哉, 木下沙英, 木村優介, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• 強度の異なる有酸素運動がマウス骨格筋に与える影響

  木下沙英, 畠山隼平, 脇川大誠, 椿俊哉, 脇本祥夫, 井上翔太, 李昌欣, 多鹿理絵, 木村優介, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• 有酸素運動によるメカニカルストレスが関節軟骨代謝に与える影響

  椿俊哉, 脇本祥夫, 井上翔太, 李昌欣, 木下沙英, 多鹿理絵, 畠山隼平, 脇川大誠, 木村優介, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese


• 異なる強度のトレッドミル走行運動による機械的刺激が骨に与える影響

  畠山隼平, 井上翔太, 脇本祥夫, 李昌欣, 木下沙英, 椿俊哉, 脇川大誠, 多鹿理絵, 木村優介, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• マウス骨格筋の肥大に至適な筋力増強運動の強度の同定

  脇川大誠, 木村優介, 畠山隼平, 椿俊哉, 木下沙英, 井上翔太, 脇本祥夫, 李昌欣, 多鹿理絵, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• マウスの認知機能を最も向上させる運動の検討

  木村優介, 脇川大誠, 脇本祥夫, 井上翔太, 畠山隼平, 木下沙英, 椿俊哉, 多鹿理絵, 李昌欣, 森山英樹

  第25回日本基礎理学療法学会学術大会, Dec. 2020, Japanese

  Others


• 高強度の超音波刺激は閉経後の骨粗鬆症を改善する－ラット卵巣摘除モデルを用いた検討－

  井上 翔太, 野村 将人, 脇本 祥夫, 森山 英樹

  第37回日本骨代謝学会学術集会, Oct. 2019, Japanese, Domestic conference

  Oral presentation


• 血中miR-133aは人工膝関節全置換術後早期のTUGと関連する

  髙村 大祐, 脇川 大誠, 畠山 隼平, 髙濱 安津子, 岩田 健太郎, 末吉 達也, 安田 義, 森山 英樹

  第7回日本運動器理学療法学術大会, Oct. 2019, Japanese, Domestic conference

  Oral presentation


• パーキンソン病患者の歩行開始動作における予測的姿勢調節とすくみ足との関連について

  永井 厚志, 沖西 正圭, 尾畠 康太, 丸本 浩平, 森山 英樹

  第17回日本神経理学療法学会学術大会, Sep. 2019, Japanese, Domestic conference

  Oral presentation


• 骨関節疾患に伴う疼痛への対応

  森山英樹

  第2回日本理学療法哲学・倫理学研究会, Jul. 2019, Japanese

  [Invited]

  Nominated symposium


• Differences in metabolism and protective-response of articular cartilage depending on different combinations of running intensity, duration, and frequency in mice

  Wakimoto Y, Mizuno E, Nomura M, Suzuki R, Inoue S, Yakuwa T, Li C, Wakigawa T, Tsubaki T, Hatakeyama J, Kinoshita S, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Effects of transcutaneous electrical stimulation on osteoporosis in ovariectomized rat

  Inoue S, Yakuwa T, Suzuki R, Aoki H, Niikura T, Oe K, Fukui T, Nomura M, Wakimoto Y, Mizuno E, Li C, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Spasticity is not the sole trigger rather is only the partial contributor of contractures after spinal cord injuries

  Kinoshita S, Ozawa J, Yakuwa T, Inoue S, Nomura M, Wakimoto Y, Li C, Hatakeyama J, Tsubaki T, Wakigawa T, Kito K, Sakai Y, Akisue T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Effects of botulinum toxin therapy on muscles and joint components responsible for contractures after spinal cord injuries

  Tsubaki T, Ozawa J, Yakuwa T, Inoue S, Nomura M, Wakimoto Y, Li C, Hatakeyama J, Kinoshita S, Wakigawa T, Kito K, Sakai Y, Akisue T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Effects of transcutaneous carbon dioxide therapy on alterations in muscles and joint components after spinal cord injury in rats

  Hatakeyama J, Inoue S, Yakuwa T, Nomura M, Wakimoto Y, Li C, Wakigawa T, Tsubaki T, Kinoshita S, Sakai Y, Akisue T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Carbon dioxide therapy improves contractures following joint immobilization

  Wakigawa T, Inoue S, Yakuwa T, Nomura M, Wakimoto Y, Li C, Hatakeyama J, Tsubaki T, Kinoshita S, Sakai Y, Akisue T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Effects of carbon dioxide therapy on the alternations in muscles and joint components following joint immobilization

  Yakuwa T, Inoue S, Nomura M, Wakimoto Y, Li C, Kinoshita S, Tsubaki T, Wakigawa T, Hatakeyama J, Sakai Y, Akisue T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Poster presentation


• Responses of articular cartilage and subchondral bone degenerated by skeletal unloading to physiological and excessive mechanical loading in mice

  Nomura M, Wakimoto Y, Inoue S, Yakuwa S, Li C, Kinoshita S, Hatakeyama J, Tsubaki T, Wakigawa T, Moriyama H

  World Confederation for Physical Therapy (WCPT) Congress 2019, May 2019, English, International conference

  Oral presentation


• 非荷重後の再荷重は軟骨下骨のスクレローシスを引き起こす：廃用を来した関節に対する積極的リハビリテーションへの警鐘

  野村 将人, 脇本 祥夫, 鈴木 崚太, 水野 絵里子, 井上 翔太, 八鍬 匠, 李 昌欣, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Oral presentation


• メカニカルストレスの強度・時間・頻度の変化が関節軟骨の基質代謝に与える影響

  脇本 祥夫, 水野 絵里子, 野村 将人, 鈴木 崚太, 八鍬 匠, 井上 翔太, 李 昌欣, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Oral presentation


• 運動強度の違いが骨格筋代謝に与える影響

  水野 絵里子, 脇本 祥夫, 野村 将人, 鈴木 崚太, 井上 翔太, 八鍬 匠, 李 昌欣, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Oral presentation


• 関節固定後の関節拘縮に対する経皮的炭酸ガス吸収療法の予防・治療効果

  井上 翔太, 野村 将人, 鈴木 崚太, 水野 絵里子, 八鍬 匠, 脇本 祥夫, 李 昌欣, 秋末 敏宏, 酒井 良忠, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Oral presentation


• 骨折治癒を促進する至適な超音波強度の検討

  鈴木 崚太, 井上 翔太, 八鍬 匠, 李 昌欣, 野村 将人, 脇本 祥夫, 水野 絵里子, 木下 紗英, 椿 俊哉, 畠山 隼平, 脇川 大誠, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Oral presentation


• 骨粗鬆症と骨折に対する経皮的な電気刺激の効果の検討

  八鍬 匠, 井上 翔太, 鈴木 崚太, 水野 絵里子, 野村 将人, 脇本 祥夫, 李 昌欣, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Poster presentation


• 超音波刺激は閉経後の骨粗鬆症を改善するーラット卵巣摘出モデルを用いた検討ー

  李 昌欣, 野村 将人, 井上 翔太, 八鍬 匠, 鈴木 崚太, 脇本 祥夫, 水野 絵里子, 森山 英樹

  第6回日本運動器理学療法学術大会, Dec. 2018, Japanese, Domestic conference

  Poster presentation


• パーキンソン病患者の歩行開始動作における予測的姿勢調節の非対称性について

  永井 厚志, 沖西 正圭, 清水 健太, 尾畠 康太, 丸本 浩平, 森山 英樹

  第16回日本神経理学療法学会学術大会, Nov. 2018, Japanese, Domestic conference

  Oral presentation


• Contrasting effects of microgravity and cyclic tensile strain on cytoskeletal actin structure and Fat1 cadherin distribution in murine articular chondrocytes

  Nomura M, Wakimoto Y, Sakitani N, Iwasawa H, Kohara Y, Shimaya S, Suzuki R, Mizuno R, Moriyama H

  8th World Congress of Biomechanics, Jul. 2018, English, International conference

  Poster presentation


• Effects of different exercises on the growth plate in young growing mice

  Mizuno E, Wakimoto Y, Nomura M, Kohara Y, Sakitani N, Shimaya S, Suzuki R, Moriyama H

  8th World Congress of Biomechanics, Jul. 2018, English, International conference

  Poster presentation


• Utilization of mechanical stress by ultrasound to accelerate fracture healing in rats

  Suzuki R, Sakitani N, Shimaya S, Nomura M, Wakimoto Y, Kohara Y, Mizuno E, Moriyama H

  8th World Congress of Biomechanics, Jul. 2018, English, International conference

  Poster presentation


• Differences in cartilage response depending on different combinations of exercise intensity, duration, and frequency in mice.

  Wakimoto Y, Kohara Y, Mizuno E, Nomura M, Sakitani N, Shimaya S, Suzuki R, Iwasawa H, Moriyama H

  8th World Congress of Biomechanics, Jul. 2018, English, International conference

  Poster presentation


• Carbon dioxide therapy improved contractures after joint immobilization in rats

  Sakitani N, Moriyama H, Miyamoto R, Nomura M, Suzuki R, Kohara Y, Mizuno E, Wakimoto Y, Yakuwa T, Inoue S, Shimaya S, Iwasawa H, Ueha T, Sakai Y, Akisue T

  8th World Congress of Biomechanics, Jul. 2018, English, International conference

  Poster presentation


• 炭酸ガス経皮吸収療法による関節拘縮の予防・治療効果

  﨑谷 直義, 森山 英樹, 酒井 良忠, 秋末 敏宏

  炭酸ガス治療研究会第3回研究集会, Feb. 2018, Japanese, 兵庫, Domestic conference

  Oral presentation


• 歩行・走行運動におけるメカニカルストレスを模した周期的圧縮-伸展刺激が軟骨細胞の遺伝子発現に及ぼす影響―培養細胞を用いた基礎的研究―

  野村 将人, 脇本 祥夫, 崎谷 直義, 岩澤 裕之, 小原 雄太, 島谷 俊亮, 鈴木 崚太, 水野 絵里子, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Oral presentation


• 中枢性麻痺後の関節拘縮に対する経皮的炭酸ガス吸収療法の治療効果

  崎谷 直義, 宮元 瑠, 野村 将人, 鈴木 崚太, 小原 雄太, 水野 絵里子, 八鍬 匠, 井上 翔太, 脇本 祥夫, 島谷 俊亮, 岩澤 裕之, 上羽 岳志, 秋末 敏宏, 酒井 良忠, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Poster presentation


• 高強度のトレッドミル運動において、低頻度の運動は膝関節軟骨の恒常性を維持する

  脇本 祥夫, 小原 雄太, 水野 絵里子, 野村 将人, 崎谷 直義, 島谷 俊亮, 鈴木 崚太, 岩澤 裕之, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Oral presentation


• 経皮的炭酸ガス吸収療法は筋の線維化と低酸素を改善することで中枢性麻痺後の関節拘縮の進行を遅らせる

  鈴木 崚太, 崎谷 直義, 髙野 祥子, 島谷 俊亮, 野村 将人, 脇本 祥夫, 小原 雄太, 水野 絵里子, 上羽 岳志, 秋末 敏宏, 酒井 良忠, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Poster presentation


• 異なる条件のトレッドミル走行が骨格筋に与える影響

  小原 雄太, 脇本 祥夫, 水野 絵里子, 野村 将人, 崎谷 直義, 鈴木 峻太, 島谷 俊亮, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Poster presentation


• 異なる運動条件がマウス成長軟骨の細胞に与える影響

  水野 絵里子, 脇本 祥夫, 小原 雄太, 野村 将人, 崎谷 直義, 島谷 俊亮, 鈴木 崚太, 森山 英樹

  第5回日本運動器理学療法学術集会, Sep. 2017, Japanese, 北海道, Domestic conference

  Poster presentation


• 痙性によるメカニカルストレスは脊髄損傷後の骨折治癒を促進する

  﨑谷 直義, 野村 将人, 岩澤 裕之, 脇本 祥夫, 森山 英樹

  第35回日本骨代謝学会学術集会, Jul. 2017, Japanese, 福岡, Domestic conference

  Oral presentation


• マウス関節軟骨および軟骨下骨に及ぼす非荷重や関節固定の影響

  野村 将人, 崎谷 直義, 脇本 祥夫, 岩澤 裕之, 森山 英樹

  第35回日本骨代謝学会学術集会, Jul. 2017, Japanese, 福岡, Domestic conference

  Oral presentation


• 基礎研究からみたエビデンス－理学療法におけるこれからの基礎研究のあり方－

  森山 英樹

  第52回日本理学療法学術大会, May 2017, Japanese, Domestic conference

  [Invited]

  Invited oral presentation


• 慢性期脳卒中患者におけるBody mass indexと筋量および筋内脂肪量との関連

  赤澤 直紀, 原田 和宏, 大川 直美, 貴志 将紀, 田村 公之, 森山 英樹

  第52回日本理学療法学術大会, May 2017, Japanese, 千葉, Domestic conference

  Oral presentation


• 超音波療法による新鮮骨折の治療促進効果の検討

  鈴木 崚太, 崎谷 直義, 高野 祥子, 島谷 俊亮, 小笠原 慎, 岩澤 裕之, 野村 将人, 脇本 祥夫, 小原 雄太, 水野 絵里子, 森山 英樹

  第52回日本理学療法学術大会, May 2017, Japanese, 千葉, Domestic conference

  Oral presentation


• 中枢性麻痺後に生じる関節拘縮に対する経皮的炭酸ガス吸収療法の効果の検討

  髙野 祥子, 﨑谷 直義, 島谷 俊亮, 岩澤 裕之, 野村 将人, 脇本 祥夫, 小原 雄太, 上羽 岳志, 秋末 敏宏, 酒井 良忠, 森山 英樹

  第52回日本理学療法学術大会, May 2017, Japanese, 千葉, Domestic conference

  Poster presentation


• 走行運動による中枢神経活性化因子の発現動態

  金村 尚彦, 村田 健児, 国分 貴徳, 今北 英高, 武本 秀徳, 森山 英樹, 前島 洋, 高柳 清美

  第52回日本理学療法学術大会, May 2017, Japanese, 千葉, Domestic conference

  Oral presentation


• ボツリヌス療法は中枢性麻痺後の関節拘縮の予防と治療において有効であるが、筋萎縮を助長する

  崎谷 直義, 渡部 大地, 野村 将人, 岩澤 裕之, 島谷 俊亮, 高野 祥子, 小笠原 慎, 脇本 祥夫, 小原 雄太, 鈴木 崚太, 水野 絵理子, 小澤 淳也, 森山 英樹

  第52回日本理学療法学術大会, May 2017, Japanese, 千葉, Domestic conference

  Oral presentation


• Mechanical unloading causes subchondral osteoclast activation resulting in thinning of articular cartilage

  Masato Nomura, Naoyoshi Sakitani, Hiroyuki Iwasawa, Yoshio Wakimoto, Shoko Takano, Yuta Kohara, Shunsuke Shimaya, MORIYAMA HIDEKI

  第3回国際再生リハビリテーションシンポジウム, Mar. 2017, Japanese, 京都, Domestic conference

  Poster presentation


• 変形性膝関節症患者の歩行・大腿四頭筋筋力強化運動時の共同収縮の変化

  脇本 祥夫, 谷本 研二, 服部 宏香, 阿南 雅也, 森山 英樹, 新小田 幸一

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  Oral presentation


• 脊髄損傷後の痙性が関節拘縮に与える影響

  島谷 俊亮, 崎谷 直義, 小澤 淳也, 渡部 大地, 野村 将人, 脇本 祥夫, 高野 祥子, 小原 雄太, 森山 英樹

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  Poster presentation


• 脊髄損傷後の骨折は通常と異なる骨化様式を経て早く治癒する

  崎谷 直義, 岩澤 裕之, 野村 将人, 脇本 祥夫, 高野 祥子, 小原 雄太, 島谷 俊亮, 伊藤 明良, 長井 桃子, 太治野 純一, 張 項凱, 山口 将希, 飯島 弘貴, 黒木 裕士, 森山 英樹

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  [Invited]

  Oral presentation


• 関節内におけるメカニカルストレスの分布の変化が関節軟骨に与える影響－マウス後肢非荷重および関節固定モデルを用いた実験的検討－

  野村 将人, 崎谷 直義, 岩澤 裕之, 髙野 祥子, 小原 雄太, 島谷 俊亮, 脇本 祥夫, 長井 桃子, 飯島 弘貴, 黒木 裕士, 森山 英樹

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  Oral presentation


• ラット脊髄損傷後の関節拘縮に対するA型ボツリヌス毒素の治療効果の検討

  小原 雄太, 崎谷 直義, 小澤 淳也, 渡部 大地, 野村 将人, 岩澤 裕之, 脇本 祥夫, 高野 祥子, 島谷 俊亮, 森山 英樹

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  Oral presentation


• ACL損傷後の疼痛に対する理学療法の有効性－システマティックレビュー・メタアナリシスによる検証－

  髙野 祥子, 渡部 大地, 岩澤 裕之, 崎谷 直義, 野村 将人, 小原 雄太, 島谷 俊亮, 脇本 祥夫, 森山 英樹

  第3回日本運動器理学療法学術集会, Dec. 2016, Japanese, 石川, Domestic conference

  Oral presentation


• Treadmill running has negative effects on arthrogenic contracture in remobilized rat knee

  Akinori Kaneguchi, Junya Ozawa, MORIYAMA HIDEKI, Nobuhiro Kito

  13th International Congress of the Asian Confederation for Physical Therapy, Oct. 2016, English, Kuala Lumpur, Malaysia, International conference

  Poster presentation


• 要介護高齢者の大腿四頭筋の筋内脂肪量と筋力との関連性

  赤澤 直紀, 大川 直美, 中谷 聖史, 森山 英樹

  第51回日本理学療法学術大会, May 2016, Japanese, 北海道, Domestic conference

  Oral presentation


• 終末糖化産物（AGEs）は固定に誘導される関節拘縮を悪化させる

  小澤 淳也, 金口 瑛典, 木藤 伸宏, 田中 亮, 森山 英樹

  第51回日本理学療法学術大会, May 2016, Japanese, 北海道, Domestic conference

  Poster presentation


• エビデンスをつくる－EBPTの課題と展望を考える－

  森山 英樹

  第1回日本運動器理学療法学会学術集会, Dec. 2015, Japanese, Domestic conference

  [Invited]

  Invited oral presentation


• Efficacy of celecoxib for the formation of joint contracture followed by immobilization in a rat

  Ozawa J, Kaneguchi A, MORIYAMA HIDEKI, Kito N, Tanaka R

  Annual European Congress of Rheumatology EULAR 2015, Jun. 2015, English, Rome, Italy, International conference

  Poster presentation


• Effects of long-term massage at the musculotendinous junction on hamstring flexibility

  Akazawa N, Okawa N, Kishi M, Nakatani K, Nishikawa K, Tokumura D, Matsui Y, MORIYAMA HIDEKI

  第50回日本理学療法学術大会, Jun. 2015, English, 東京, Domestic conference

  Poster presentation


• Effect of balance exercise training on neuromuscular function after peripheral nerve injury of adult rats

  Kanemura N, Imagita H, Takemoto H, Murata K, Kokubun T, Fujino T, MORIYAMA HIDEKI, Takayanagi K

  9th World Congress of the International Society of Physical and Rehabilitation Medicine (ISPRM), Jun. 2015, English, Berlin, Germany, International conference

  Poster presentation


• Does exercise therapy improve health-related quality of life in people with knee osteoarthritis? a systematic review

  Tanaka R, Ozawa J, Kito N, MORIYAMA HIDEKI

  Annual European Congress of Rheumatology EULAR 2015, Jun. 2015, English, Rome, Italy, International conference

  Oral presentation


• The effects of heat, icing, and stretching on knee joint capsule in rat contracture model of spinal cord injury

  Hiroyuki Iwasawa, Naoyoshi Sakitani, Masato Nomura, Daichi Watanabe, Kosuke Watanabe, MORIYAMA HIDEKI, Shoko Takano

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Spinal cord injury leads to region specific tidemark advancement in articular cartilage of the knee joint in rats

  Masato Nomura, Hiroyuki Iwasawa, Naoyoshi Sakitani, Koshuke Watanabe, Daichi Watanabe, Shoko Takano, MORIYAMA HIDEKI

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Efficacy of cane and crutch in middle aged and older individuals: a systematic review and meta-analysis

  Daichi Watanabe, Masato Nomura, Koshuke Watanabe, Naoyoshi Sakitani, Hiroyuki Iwasawa, MORIYAMA HIDEKI

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Effects of treadmill running on diaphragm and hind-limb muscles in rats with emphysema

  Hidetaka Imagita, Yasue Nishii, Tadayuki Mita, Keisuke Okada, Taku Yamakami, MORIYAMA HIDEKI, Naohiko Kanemura, Shinnosuke Kawata

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Effects of spinal cord injury on fracture healing in rats

  Naoyoshi Sakitani, Daichi Watanabe, Hiroyuki Iwasawa, Masato Nomura, Kosuke Watanabe, Shoko Takano, MORIYAMA HIDEKI

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Comparison of thermal and cold therapy combined with stretching for correction of contracture after spinal cord injury in rats

  MORIYAMA HIDEKI, Hitomi Atsuji, Yui Usumoto, Junya Ozawa, Nobuhiro Kito, Ryo Tanaka, Naohiko Kanemura, Masataka Deie

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Changes of muscular and articular factors in joint contracture after spinal cord injury in rats

  Kosuke Watanabe, Hiroyuki Iwasawa, Naoyoshi Sakitani, Masato Nomura, Daichi Watanabe, MORIYAMA HIDEKI

  World Confederation for Physical Therapy (WCPT) Congress 2015, May 2015, English, Singapore, Singapore, International conference

  Poster presentation


• Selective COX-2 inhibitor celecoxib partially attenuates joint contracture followed by immobilization in a rat

  Junya Ozawa, Akinori Kaneguchi, Ryo Tanaka, Kimihiko Tokumori, MORIYAMA HIDEKI

  4th Asia-Oceanian Conference of Physical and Rehabilitation Medicine (AOCPRM) 2014, Dec. 2014, English, Bangkok, Thailand, International conference

  Poster presentation


• Locomotion abnormalities and the subsequent ankle muscle atrophy are induced by hip adductor muscle weakness in a rat

  Junya Ozawa, Akinori Kaneguchi, Nobuhiro Kito, Ryo Tanaka, MORIYAMA HIDEKI

  4th Asia-Oceanian Conference of Physical and Rehabilitation Medicine (AOCPRM) 2014, Dec. 2014, English, Bangkok, Thailand, International conference

  Poster presentation


• Effects of exercise therapy on walking ability in individuals with knee osteoarthritis: A systematic review and meta-analysis of randomised controlled trials

  Ryo Tanaka, Junya Ozawa, Nobuhiro Kito, MORIYAMA HIDEKI

  4th Asia-Oceanian Conference of Physical and Rehabilitation Medicine (AOCPRM) 2014, Dec. 2014, English, Bangkok, Thailand, International conference

  Poster presentation


• 骨折の治癒過程は脊髄損傷により改変される

  崎谷 直義, 岩澤 裕之, 野村 将人, 渡辺 昴介, 渡辺 大地, 高野 祥子, 森山 英樹

  兵庫県骨・カルシウムを語る会, Nov. 2014, Japanese, 兵庫, Domestic conference

  Oral presentation


• 運動動様式の違いが老齢ラット腰髄神経活性化に与える影響

  金村 尚彦, 村田 健児, 国分 貴徳, 武本 秀徳, 今北 英高, 藤野 努, 森山 英樹, 高柳 清美

  第33回関東甲信越ブロック理学療法士学会, Oct. 2014, Japanese, 千葉, Domestic conference

  Poster presentation


• 健常成人男性のHip flexion angle値におけるMinimal clinically important differenceの検討

  赤澤 直紀, 原田 和宏, 大川 直美, 中谷 聖史, 北裏 真己, 松井 有史, 森山 英樹

  第49回日本理学療法学術大会, May 2014, Japanese, 神奈川, Domestic conference

  Oral presentation


• 『知的財産権取得』ウォーキング用の杖「R9-STICK」の試作とモニタリング

  石間伏 勝博, 大浦 由紀, 森山 英樹

  第49回日本理学療法学術大会, May 2014, Japanese, 神奈川, Domestic conference

  Poster presentation


• 変形性膝関節症とメカニカルストレス 基礎研究の視点から

  MORIYAMA HIDEKI

  第53回近畿理学療法学術大会, Nov. 2013, Japanese, 京都, Domestic conference

  [Invited]

  Nominated symposium


• Effect of balance exercise on plasticity after peripheral nerve injury of adult rats

  Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Tsutomu Fujino, Hidenori Takemoto, Nobuhiro Kito, MORIYAMA HIDEKI, Hidetaka Imagita, Hiroshi Maejima, Kiyomi Takayanagi

  6th Asia Western Pacific Region of the World Confederation for Physical Therapy & 12th Asian Confederation for Physical Therapy Congress 2013, Sep. 2013, English, Taichung, Taiwan, International conference

  Poster presentation


• Diagnostic accuracy of knee and hip muscle strength measurements in patients with knee osteoarthritis

  Nobuhiro Kito, Takahiro Yamasaki, Masaya Anan, Ryo Tanaka, Junya Ozawa, Naohiko Kanemura, MORIYAMA HIDEKI, Koichi Shinkoda

  6th Asia Western Pacific Region of the World Confederation for Physical Therapy & 12th Asian Confederation for Physical Therapy Congress 2013, Sep. 2013, English, Taichung, Taiwan, International conference

  Poster presentation


• 変形性膝関節症罹患者の歩行時の内部股関節外転モーメントが外部膝関節内反モーメントに与える影響について

  木藤 伸宏, 山﨑 貴博, 田中 亮, 小澤 淳也, 阿南 雅也, 森山 英樹, 金村 尚彦, 新小田 幸一

  第48回日本理学療法学術大会, May 2013, Japanese, 愛知県, Domestic conference

  Oral presentation


• 変形性膝関節症罹患者の機能障害，活動制限，健康関連QOL低下に対する運動療法は治療開始150日を超えても有効か？－ランダム化比較試験のシステマティックレビューおよびメタアナリシス

  田中 亮, 小澤 淳也, 木藤 伸宏, 山﨑 貴博, 森山 英樹, 南有田 くるみ

  第48回日本理学療法学術大会, May 2013, Japanese, 愛知県, Domestic conference

  Oral presentation


• 走行運動及び足関節筋力低下状態での走行運動が膝関節軟骨に及ぼす影響

  小澤 淳也, 金口 瑛典, 木藤 伸宏, 田中 亮, 森山 英樹

  第48回日本理学療法学術大会, May 2013, Japanese, 愛知県, Domestic conference

  Poster presentation


• ラット脊髄におけるグリア細胞株由来栄養因子－受容体mRNA発現量に対するバランス運動の影響

  金村 尚彦, 森山 英樹, 今北 英高, 前島 洋, 武本 秀徳, 木藤 伸宏, 国分 貴徳, 村田 健児, 五味 敏昭, 高柳 清美

  第48回日本理学療法学術大会, May 2013, Japanese, 愛知県, Domestic conference

  Poster presentation


• 変形性関節症の生物学

  森山 英樹

  第52回近畿理学療法学術大会, Nov. 2012, Japanese, 奈良県, Domestic conference

  [Invited]

  Invited oral presentation


• Locomoter exercise enhances selectively their expression of neurotrphin and receptors in the spinal cord of aged rat

  Naohiko Kanemura, MORIYAMA HIDEKI, Hidenori Takemoto, Hidetaka Imagita, Hiroshi Maejima, Takanori Kokubun, Ken Nishihara, Kiyomi Takayanagi

  Neuroscience 2012, SfN's 42nd annual meeting, Oct. 2012, English, New Orleans, USA, International conference

  Poster presentation


• 変形性膝関節症を伴う疼痛に対する運動介入の短期的効果は非荷重位筋力増強運動が最も高い─ランダム化比較試験に対するメタアナリシス─

  田中 亮, 小澤 淳也, 木藤 伸宏, 森山 英樹

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Oral presentation


• 内側型変形性膝関節症に対する膝外反装具が大腿骨-脛骨運動に与える影響

  浅枝 諒, 折田 直哉, 岩城 大介, 細 貴幸, 森山 英樹, 出家 正隆

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Poster presentation


• 脊髄損傷後の関節軟骨におけるストレッチの影響─ラットモデルによる実験的検討─

  森山 英樹, 阿閉 瞳, 高橋 由妃, 渡邉 良平, 島田 昇, 折田 直哉, 金村 尚彦, 小澤 淳也, 木藤 伸宏, 出家 正隆

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Poster presentation


• 高位脛骨骨切り術後患者の歩行中膝関節力学的負荷(外部膝関節内反モーメントとlateral thrust)の経時的変化

  島田 昇, 平田 和彦, 日當 泰彦, 折田 直哉, 細 貴幸, 岩城 大介, 河江 敏広, 史 明, 對東 俊介, 松木 良介, 森山 英樹

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Oral presentation


• ラット脊髄における神経成長因子－受容体mRNA発現量に対する走行運動の影響

  金村 尚彦, 森山 英樹, 今北 英高, 武本 秀徳, 木藤 伸宏, 国分 貴徳, 碇 友子, 五味 敏昭, 高柳 清美

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Poster presentation


• Botulinum toxin投与による足関節底屈筋力低下が関節軟骨代謝に及ぼす影響

  小澤 淳也, 金口 瑛典, 田中 亮, 木藤 伸宏, 森山 英樹

  第47回日本理学療法学術大会, May 2012, Japanese, 兵庫県, Domestic conference

  Oral presentation


• Experimental joint contracture correction with static and cyclic stretching for contracture formation after spinal cord injury in rats

  Moriyama H, Otsuka C, Marumo T, Kanemura N, Ozawa J, Kito N, Imagita H, Deie M

  16th International Congress of the World Confederation for Physical Therapy (WCPT), Jun. 2011, English, International conference

  Poster presentation


• 理学療法効果を検証するためのシステマティックレビューの作成方法と実践

  森山 英樹

  第45回日本理学療法学術大会, May 2010, Japanese, Domestic conference

  [Invited]

  Invited oral presentation


• Effects of aging and exercise training on the mechanical properties of articular structures in rat knee joints

  Moriyama H, Kanemura N, Nishihara K, Takayanagi K, Gomi T, Hayashi H, Ozawa J, Tobimatsu Y

  5th World Congress of the International Society of Physical and Rehabilitation Medicine, Jun. 2009, English, International conference

  Poster presentation


• EBPTに関する骨・関節系理学療法研究部会の活動とその展開－システマティックレビューの作成法

  森山 英樹

  第44回日本理学療法学術大会, May 2009, Japanese, Domestic conference

  [Invited]

  Invited oral presentation


• Comparison of muscular and articular factors during joint contracture formation in acute spinal cord injury

  Moriyama H, Kanemura N, Takayanagi K, Naruse H, Kido S, Sunaga Y, Suzuki Y, Araki T, Hosoda M, Tobimatsu Y

  10th International Congress of the Asian Confederation for Physical Therapy, Aug. 2008, English, International conference

  Poster presentation


• Contrasting alterations of anterior and posterior articular cartilage of rat knee joints after spinal cord injury

  Moriyama H, Yoshimura O, Takayanagi K, Kubota A, Araki T, Suzuki Y, Nakamura Y, Tobimatsu Y

  15th International World Confederation for Physical Therapy Congress, Jun. 2007, English, International conference

  Poster presentation


• Application in treatments for contractures after central nervous system injury: a study using spinal cord-injured rats

  Moriyama H, Maejima H, Saka Y, Sakamoto N, Sunahori H, Imagita H, Nitta H, Yoshimura O

  11th International Society for Prosthetics and Orthotics World Congress, Aug. 2004, English, International conference

  Poster presentation


• Contractures following spinal cord injury: an experimental study in the rat

  Moriyama H, Tsutsumi E, Ozawa J, Watanabe M, Takemoto H, Kanemura N, Sasaki H, Tanaka S, Shirahama K, Katou H, Kawamoto I, Miyamoto H, Shimoi T, Sunahori H, Saka Y, Maejima H, Yoshimura O

  14th International World Confederation for Physical Therapy Congress, Jun. 2003, English, International conference

  Poster presentation

• Euro-BioImaging


• Japanese Society for Musculoskeletal Medicine


• Japanese Physical Therapy Association


• World Confederation for Physical Therapy


• 炭酸ガス治療研究会


• 日本組織細胞化学会


• 日本骨代謝学会


• 日本軟骨代謝学会


• 専門リハビリテーション研究会


• 日本運動器科学会


• 日本理学療法士協会

• Relationships between femoral morphological abnormalities / joint malalignment and locomotor disorders

  小澤 淳也, 森山 英樹, 金口 瑛典

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Hiroshima International University, 01 Apr. 2021 - 31 Mar. 2026

  本年度の研究では，筋骨格が未成熟なラットを用い，免荷による後肢へのメカニカルストレスの減少が，1)大腿骨形態，2)膝関節アライメント，3)膝関節機械的特性に及ぼす影響を調査した．4週齢の雌性ラットに後肢懸垂を2，4，8週間実施し，以下の実験を行った． 1)では，X線CT撮影画像を用い，大腿骨幾何学形態への影響を調査した．後肢懸垂により，大腿骨近位では，頚部前捻角（Anteversion angle: AVA）が増加した．大腿骨遠位では，外側顆部（Lateral condyle: LC）では成長が抑制された一方で，内側顆部（medial condyle: MC）には成長に影響を及ぼさなかった．滑車角（Trochlear angle : TA）は，成長に伴い生じる外方から内方への傾斜が，後肢懸垂により抑制された．AVA，LC，MC/LC, TAの間には強い相関が認められた． 2)では，膝関節アライメントに及ぼす影響を調査した．後肢懸垂により，大腿骨に対する膝蓋骨の傾斜角度（Patellar Tilt Angle）は外方に傾斜し，脛骨粗面－滑車溝間距離（TT－TG）により脛骨の外旋が示された．加えて，膝蓋骨の側方変位の指標であるBisect offsetは，膝蓋骨の外方への移動を示した． 3)では，膝関節全体および前十字靭帯（Anterior Cruciate Ligament: ACL）における機械的特性への影響を調査した．万能試験機を用い，後肢懸垂後の膝関節弛緩性（Joint laxity），ACLのstiffnessおよび破断強度を調査した．その結果，4-8週間の後肢懸垂により，いずれの機械的強度の指標も変化し，関節弛緩性が出現することが示された．


• 理学療法の革新的展開に向けた慢性炎症を軸とする運動の万能性の解明

  森山 英樹

  日本学術振興会, 科学研究費助成事業／基盤研究(B), 神戸大学, 2023 - 2026, Principal investigator


• 老化の防止に挑む運動の理論的基盤の構築とその応用による運動模倣薬の開発

  森山 英樹

  日本学術振興会, 科学研究費助成事業／基盤研究(B), 神戸大学, 2019 - 2022, Principal investigator

  Competitive research funding


• Development of new therapy for joint contractures using percutaneous carbon dioxide application.

  Akisue Toshihiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Kobe University, 30 Jun. 2017 - 31 Mar. 2021

  Joint contractures are a major complication following injuries in central nervous system or joint immobilization. However, no effective treatment has been developed so far. In the present study, we aimed to develop a novel therapeutic approach for joint contractures using transcutaneous carbon dioxide absorption. Our findings indicate that transcutaneous carbon dioxide may improve knee range of motion after injuries central nervous system or joint immobilization. We also revealed that transcutaneous carbon dioxide decreases muscular and articular fibrosis, thereby improving knee joint contracture.


• いわゆる「運動神経の良さ」を明らかにする

  森山 英樹

  日本学術振興会, 科学研究費助成事業／挑戦的研究(萌芽), 2019 - 2021, Principal investigator

  Competitive research funding


• 骨粗鬆症に対する物理的刺激を活用した新たな包括的治療法の開発

  森山 英樹

  鈴木謙三記念医科学応用研究財団, 平成29年度調査研究助成, 2017 - 2018, Principal investigator

  Competitive research funding


• 物理的刺激を活用した骨折に対する新たな包括的治療の開発

  森山 英樹

  日本学術振興会, 科学研究費助成事業／挑戦的萌芽研究, 2016 - 2018, Principal investigator

  Competitive research funding


• Implications of AGEs for the development of OA and contracture

  Ozawa Junya, KITO NOBUHORO, MORIYAMA HIDEKI, TANAKA RYO

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Hiroshima International University, 01 Apr. 2014 - 31 Mar. 2017

  We examined the effects of hypo- and hyperactivity of joint with accumulation of AGEs. First, a combination of AGEs accumulation and treadmill running was tested. AGEs accumulated knee joint was not induced any pathological changes. Second, we tested the effects of AGEs on joint mobility. AGEs accumulation in joint components did not affect joint mobility. However, joint contracture following immobilization was aggravated in AGEs accumulating joints with concomitant upregulation of collagen genes and protein in joint capsule. This study is the first to elucidate the relationship between AGEs and joint contracture formation following immobilization via enhancement of fibrosis in joint capsule.


• Effects of treadmill exercise on respiratory function, diaphragm muscular function and respiratory center in rats with emphysema.

  IMAGITA HIDETAKA, KANEMURA Naohiko, MORIYAMA Hideki, FUJITA Naoto, NISHII Yasue

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kio University, 01 Apr. 2012 - 31 Mar. 2016

  The purpose of this study was to determine the effects of treadmill exercise on respiratory function and skeletal muscle in rats with emphysema. Wistar rats were randomly divided into three groups: the sham (SH) group, pulmonary emphysema (PE) group, and emphysema + exercise (EX) group. Cigarette smoke solution and lipopolysaccharide were intratracheally administered for 4 weeks in the PE and EX groups. The rats in the EX group were made to run on treadmills in the latter 2 weeks of the experiment. Many macrophages were observed in the lung tissue of the PE group. In the EX group, however, the population of macrophages was smaller and the specific force of the diaphragm and EDL muscles was higher than in the PE group. Moreover, the degree of inflammation in the pulmonary tissue was reduced in the EX group. These results suggest that adaptive exercise may improve not only respiratory and muscle functions but also inflammation of the pulmonary tissue associated with emphysema.


• メカニカルストレスを基軸とする運動器障害の発生機序解明：リハビリテーションの再考

  森山 英樹

  日本学術振興会, 科学研究費助成事業／若手研究(A), 2013 - 2016, Principal investigator

  Competitive research funding


• Elucidation of enhanced process in aging central nerve by the running and balance exercise

  KANEMURA Naohiko, TAKAYANAGI Kiyomi, IMAGITA Hidetaka, MORIYAMA Hideki, MAEJIMA Hiroshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Saitama Prefectural University, 01 Apr. 2012 - 31 Mar. 2015

  Moderate exercise, the release of neurotrophic factors is increased , neural activity is activated. In this study, whether it is possible to activate the nervous system that has been decreased by aging and to verify the effect of the running and balance exercise. Activation of the motor neurons stained of the lumbar spinal cord was less change in some exercise. Their expression of neurotrophins, neurogenesis and neurpeptide were enhanced and the activity of apotosis wad down-regulated by locomotor exercise in the spinal cord of the difference of age. Improvements due to the motion, not the nerve itself, it is necessary to consider in the pleiotropic functions for related factors activated neural activity.


• 脊髄損傷後の骨折から新たな骨折治癒促進法を探る

  森山 英樹

  日本学術振興会, 科学研究費助成事業／挑戦的萌芽研究, 2013 - 2015, Principal investigator

  Competitive research funding


• 中枢性麻痺後の筋と関節包の網羅的解析による関節拘縮の発生機序の解明

  森山 英樹

  中冨健康科学振興財団, 平成23年度（第24回）研究助成金, 2011 - 2012, Principal investigator

  Competitive research funding


• Development of a new anti-tumor therapy by occlusion of blood vessels

  DEIE Masataka, MORIYAMA Hideki

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Hiroshima University, 2010 - 2012

  The purpose of this study is to develop a new anti-tumor therapy that blocks blood-flow to the tumor and necrotizes the tumor. First, we erected a method that couples microbeads with blood cells. Secondly, we glued a magnet to the surface of rat’s skull and injected the microbead - blood cell complexes into the rat’s internal carotid artery. As a result, we succeeded to occlude the rat’s middle cerebral artery. To lessen the damage to rats and to make the surgical technique simple, we conducted next experiment under another condition. The experiment showed that the middle cerebral artery of a rat was not occluded in that condition.


• Elucidation of the natural healing mechanism after knee anterior cruciate ligament tear and it's clinical application

  TAKAYANAGI Kiyomi, KANEMURA Naohiko, KOKUBUN Takanori, NISHIKAWA Yuichi, IHARA Hidetoshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Saitama Prefectural University, 2009 - 2011

  The natural healing of the ruptured anterior cruciate ligament(ACL) using a new animal model was observed by mechanical, histological and immunohistochemistrical methods. The ACL was cut completely by the mini-scissors and then the knee joint was controlled normally with artificial ligament. The ruptured ACL was healed in all rats. Eight weeks after ACL cutting, the Type III collagen was increased in the healing ligament. After 8 weeks and 40 weeks after the ACL cut, the healing ligament was half strength compared to the normal ligament. The expression of MMP-1, MMP-13 and TIMP-1 in medial and lateral meniscus and rupture ACL was increased after ACL cut. Expression of MMP-13 in the joint control group has been suppressed compared to the no joint control group. It is suggested that abnormal joint movement under the gravity is increased to express of proteolytic enzymes of both meniscus and rupture ACL in the knee joint.


• Physical exercise enhanced the sensory function in the knee joint with aging and disuse

  KANEMURA Naohiko, IMAGITA Hidetaka, TAKEMOTO Hidenori, TAKAYANAGI Kiyomi, MORIYAMA Hideki, MORIYAMA Hideki, KITO Nobuhiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Saitama Prefectural University, 2009 - 2011

  The purpose of study is to analyze whether physical exercise enhanced the neural function in the knee joint with aging and disuse. Exercised rats showed a quantitative increase neurotrophin immunostaining that was mostly evident in the spinal cords. In biochemical assay, exercise increases selectively expression of neurotrophins and receptors mRNA in the lumber spinal cord in senescence. These results suggest that exercise enhanced neurotrophins and their receptors by physiological process that it is endogenous in the lumber spinal cords which innervate the knee joints.


• 中枢性麻痺に伴う関節拘縮に対する治療戦略の探索と基盤確立

  森山 英樹

  文部科学省, 科学研究費補助金／若手研究(B), 2009 - 2011, Principal investigator

  Competitive research funding


• Effects of respiratory function and diaphragm muscle on rats with cervical spinal cord injury

  IMAGITA Hidetaka, KANEMURA Naohiko, MORIYAMA Hideki, KANEMURA Naohiko, MORIYAMA Hideki, TAKEMOTO Hidenori, SHINDOU Hanae, NISHIO Syunsuke, NISHIKAWA Akira

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kio University, 2008 - 2010

  The purpose of this study is to analyze the effects on the respiratory function and diaphragm muscle of Wistar rats with cervical spinal cord injury. After the operation, the tidal volume of rats with C2 level injury decreased about 5%, and that of rats with C3 level about 25%. The tidal volume of rats with C5 to C7 levels has decreased about 75-95%. In contrast, their diaphragm muscle activity has increased about 10-20%. It could bring out that the respiratory function of patients with cervical spinal cord injury not only affects the activity levels of daily living but also has a significant effect on life support.


• Search of natural healing for conservative treatment after anterior cruciate ligament rupture

  TAKAYANAGI Kiyomi, MORIYAMA Hideki, KANEMURA Naohiko, HOSODA Masataka, IHARA Hidetosi, SAWADA Tomoki, MOTIZUKI Teppei, TIGIRA Tomohiko

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Saitama Prefectural University, 2007 - 2008

  前十字靱帯は完全断裂であっても関節運動の制動と早期から運動を行うことによって, 破断したACL が治癒することを証明するための動物実験モデルを作製することが本研究の主目的であった.後肢懸垂モデル, 関節包外関節制動モデルを考案し, 靱帯の治癒を検証した.後肢懸垂モデルでは索状の瘢痕組織が観察されたが, 荷重運動を開始すると瘢痕組織は消失し, 変形性膝関節症が発生した.関節包外関節制動モデルでは肥厚した瘢痕組織が観察されたが, 結果にばらつきが発生し, 関節コントロールが関連すると考えた.


• 中枢性麻痺に伴う関節拘縮の原因となる関節構造内の変性の解明

  森山 英樹

  文部科学省, 科学研究費補助金／若手研究(B), 2007 - 2008, Principal investigator

  Competitive research funding