Research activity information

• Oct. 2024 日本脳神経外科コングレス, CNS 2024 Annual Meeting (Houston, TX | September 28-October 2, 2024), A Novel Nomogram to Predict Immediate Postoperative Facial Nerve Function after Vestibular Schwannoma Resection

  藤田 祐一


• Jun. 2020 71st Annual Meeting of the German Society of Neurosurgery, Young Traveler Awards, Diffusion-weighted imaging for monitoring the response of malignant gliomas to photodynamic therapy

  Yuichi Fujita


• May 2020 2020 CNS Annual Meeting, Travel Award, Intraoperative 3-T magnetic resonance spectroscopy for detection of proliferative remnants of glioma

  Yuichi Fujita

• A morphological features-based nomogram for predicting facial nerve function in the immediate postoperative period after vestibular schwannoma surgery.

  Yuichi Fujita, Yoichi Uozumi, Yosuke Fujimoto, Hiroaki Nagashima, Masaaki Kohta, Kazuhiro Tanaka, Hidehito Kimura, Atsushi Fujita, Eiji Kohmura, Takashi Sasayama

  PURPOSE: Tumor morphology critically influences facial nerve (FN) outcomes following vestibular schwannoma (VS) surgery. This study aimed to develop a nomogram based on preoperative features for preoperative prediction of FN outcomes after VS surgery. METHODS: A retrospective analysis included patients with sporadic VS who underwent surgical resection via the retrosigmoid approach. Tumor size was assessed using the Koos grade, the intrameatal components using the fundal fluid cap (FFC) sign, and the cerebellopontine angle cisternal components using our modified morphological subclassification. Logistic regression analysis was performed to construct a nomogram for predicting immediate postoperative FN function. RESULTS: A total of 265 patients with VS met the inclusion criteria. Of these patients, 62 (23.4%) had poor FN function (House-Brackmann grade ≥ III) immediately after surgery. Univariate logistic regression analysis identified the Koos grade (p = 0.001), FFC sign (p = 0.023), and morphological subtype (p < 0.001) as significant predictors of poor FN function immediately after surgery. In multivariate logistic regression analysis, the FFC sign (OR 2.07, p = 0.042) and morphological subtype (OR 8.21, p < 0.001) remained statistically significant independent predictors of poor FN function. A nomogram constructed based on these indicators demonstrated good discrimination in the training cohort (area under the curve [AUC] 0.80), internal validation cohort (AUC 0.79), and external validation cohort (AUC 0.97). CONCLUSIONS: A simple and reliable nomogram incorporating the Koos grade, FFC sign, and morphological subtype accurately predicts the risk of FN injury during surgery aimed at total resection of VS. This clinically straightforward tool can assist in patient counseling and development of more individualized surgical strategies to improve FN outcomes in patients with VS.

  Mar. 2025, Journal of neuro-oncology, English, International magazine

  [Refereed]

  Scientific journal


• Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases.

  Yosuke Fujimoto, Yuichi Fujita, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Yusuke Ikeuchi, Hirofumi Iwahashi, Shoji Sanada, Yoshihiro Muragaki, Takashi Sasayama

  BACKGROUND AND OBJECTIVES: Photodynamic therapy (PDT) with talaporfin sodium is an intraoperative local therapy administered after the surgical removal of malignant gliomas. However, its clinical efficacy in a large patient population has not been determined. To analyze the clinical outcomes and prognosis in isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients treated with PDT. METHODS: This retrospective study included patients with newly diagnosed IDH-wildtype glioblastoma treated at Kobe University Hospital between January 2013 and December 2022. PDT involves irradiation of the resection cavity with a 664-nm semiconductor laser after an intravenous infusion of talaporfin sodium. The main outcome measures were the recurrence patterns and survival times, which were compared between the PDT and non-PDT groups. Univariate and multivariate analyses were used to determine the prognostic factors. In addition, adverse events and prognostic factors in the PDT group were analyzed. RESULTS: A total of 44 and 56 patients were included in the PDT and non-PDT groups, respectively. The local recurrence rate was significantly lower in the PDT group than in the non-PDT group (51.3% vs 83.9%), whereas the distant recurrence and dissemination rates were significantly higher in the PDT group than in the non-PDT group (48.7% vs 16.1%). Two grade 3 adverse events were observed in the PDT group. The median progression-free survival and overall survival times were significantly longer in the PDT group than in the non-PDT group (progression-free survival: 10.8 vs 9.3 months, respectively, and overall survival: 24.6 vs 17.6 months, respectively). Multivariate analysis of the PDT groups revealed that younger age was an independent prognostic factor. CONCLUSION: PDT with talaporfin sodium provided effective local control with minimal adverse effects. The survival time of the patients treated with PDT was significantly longer than that of the patients who did not receive PDT. Therefore, a randomized controlled clinical trial on PDT is warranted.

  Nov. 2024, Neurosurgery, English, International magazine

  [Refereed]

  Scientific journal


• Indocyanine green fluorescence visualizes landmark arteries for endoscopic sinus and skull base surgery.

  Go Inokuchi, Mihoko Mine, Kotaro Tamagawa, Shun Tatehara, Mitsuko Yui, Youichi Uozumi, Yuichi Fujita, Tomoaki Nakai, Ken-Ichi Nibu

  OBJECTIVE: Landmark arteries during endoscopic sinus surgery are currently identified on the basis of anatomy, CT imaging and navigation, and Doppler flowmetry. However, the advantage of intraoperative fluorescence imaging during endoscopic sinus surgery has not been demonstrated. This study aimed to investigate whether Indocyanine Green (ICG) is useful for visualizing landmark arteries during endoscopic sinus and skull base surgery. METHODS: Eight patients who underwent endoscopic sinus and pituitary surgeries and consented to study participation were included. After planned procedures were performed as usual, landmark arteries were examined by ICG endoscope. Recorded video and preoperative CT images were analyzed for identification of five landmark arteries: anterior ethmoidal artery (AEA), posterior ethmoidal artery (PEA), internal carotid artery (ICA), sphenopalatine artery (SPA), and postnasal artery (PNA). Identification of arteries was evaluated three grades: identifiable, locatable, unrecognizable. RESULTS: Eight patients and eleven sides were evaluated. The ICG dose was 2.5 mg/body and a single shot was sufficient for evaluation. 100 % of AEA was identified (9/9 sides), 86 % of PNA (6/7 sides), 56 % of ICA (5/9 sides), and 25 % of PEA and SPA (2/8 sides). CONCLUSION: ICG could visualize landmark arteries, even thin arteries like AEA, during endoscopic sinus and skull base surgeries. Visualization was affected by thickness of bone or soft tissue above arteries, blood clots, sensitivity setting, and angle and distance of near-infrared light irradiation. ICG visualization of landmark arteries may help avoid vascular injuries during endoscopic sinus and skull base surgeries, particularly of AEA, PNA and ICA.

  May 2024, American journal of otolaryngology, 45(4) (4), 104343 - 104343, English, International magazine

  [Refereed]

  Scientific journal


• Clival Aspergilloma

  Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama

  Mar. 2024, AJNR. American journal of neuroradiology, English

  [Refereed]

  Scientific journal


• Delayed facial palsy after resection of vestibular schwannoma: does it influence long-term facial nerve functional outcomes?

  Yuichi Fujita, Yoichi Uozumi, Nobuyuki Akutsu, Takashi Sasayama, Eiji Kohmura

  OBJECTIVE: Delayed facial palsy (DFP) is a common and unique complication after resection of vestibular schwannoma (VS). Few studies have focused on the clinical question of whether patients with DFP can be expected to have the same long-term prognosis in terms of facial nerve function as those without DFP based on their facial nerve function immediately postoperatively. This study aimed to clarify the clinical impact of DFP on the long-term functional status of the facial nerve after VS resection. METHODS: The authors retrospectively reviewed patients with sporadic VS who were treated surgically via a retrosigmoid approach between January 2002 and March 2020. DFP was defined as de novo deterioration of facial nerve function by a House-Brackmann (HB) grade ≥ I more than 72 hours postoperatively. The incidence of DFP after VS resection and its impact on long-term facial nerve function were analyzed. RESULTS: DFP developed in 38 (14.3%) of 266 patients who met the inclusion criteria. The median latency until DFP onset postoperatively was 8.5 days. When facial nerve function was normal immediately postoperatively, the rate of preservation of favorable facial nerve function (HB grade I or II) at 24 months postoperatively was 100% for all patients regardless of whether they developed DFP. In contrast, when facial nerve dysfunction was present immediately postoperatively, the rate of preservation of favorable facial nerve function at 24 months postoperatively was significantly lower in patients with DFP than in those without DFP (77.8% vs 100% in patients with HB grade II immediately postoperatively, p = 0.001; 50.0% vs 90.3% in those with HB grade III immediately postoperatively, p = 0.042). DFP development had a significantly negative impact on the long-term functional status of the facial nerve postoperatively when age, tumor size, and HB grade immediately postoperatively were taken into account (OR 0.04, 95% CI 0.01-0.20; p < 0.001). CONCLUSIONS: DFP can be a minor complication when normal facial nerve function is observed immediately after surgery. However, when facial nerve dysfunction is present immediately after surgery, even if mild, the long-term prognosis for facial nerve function is significantly worse in patients with DFP than in those without DFP.

  Dec. 2023, Journal of neurosurgery, 1 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Subclassification of Koos grade 4 vestibular schwannoma: insights into tumor morphology for predicting postoperative facial nerve function.

  Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama, Eiji Kohmura

  OBJECTIVE: Koos grade 4 vestibular schwannoma (KG4VS) is a large tumor that causes brainstem displacement and is generally considered a candidate for surgery. Few studies have examined the relationship between morphological differences in KG4VS other than tumor size and postoperative facial nerve function. The authors have developed a landmark-based subclassification of KG4VS that provides insights into the morphology of this tumor and can predict the risk of facial nerve injury during microsurgery. The aims of this study were to morphologically verify the validity of this subclassification and to clarify the relationship of the position of the center of the vestibular schwannoma within the cerebellopontine angle (CPA) cistern on preoperative MR images to postoperative facial nerve function in patients who underwent microsurgical resection of a vestibular schwannoma. METHODS: In this paper, the authors classified KG4VSs into two subtypes according to the position of the center of the KG4VS within the CPA cistern relative to the perpendicular bisector of the porus acusticus internus, which was the landmark for the subclassification. KG4VSs with ventral centers to the landmark were classified as type 4V, and those with dorsal centers as type 4D. The clinical impact of this subclassification on short- and long-term postoperative facial nerve function was analyzed. RESULTS: In this study, the authors retrospectively reviewed patients with vestibular schwannoma who were treated surgically via a retrosigmoid approach between January 2010 and March 2020. Of the 107 patients with KG4VS who met the inclusion criteria, 45 (42.1%) were classified as having type 4V (KG4VSs with centers ventral to the perpendicular bisector of the porous acusticus internus) and 62 (57.9%) as having type 4D (those with centers dorsal to the perpendicular bisector). Ventral extension to the perpendicular bisector of the porus acusticus internus was significantly greater in the type 4V group than in the type 4D group (p < 0.001), although there was no significant difference in the maximal ventrodorsal diameter. The rate of preservation of favorable facial nerve function (House-Brackmann grades I and II) was significantly lower in the type 4V group than in the type 4D group in terms of both short-term (46.7% vs 85.5%, p < 0.001) and long-term (82.9% vs 96.7%, p = 0.001) outcomes. Type 4V had a significantly negative impact on short-term (OR 7.67, 95% CI 2.90-20.3; p < 0.001) and long-term (OR 6.05, 95% CI 1.04-35.0; p = 0.045) facial nerve function after surgery when age, tumor size, and presence of a fundal fluid cap were taken into account. CONCLUSIONS: The authors have delineated two different morphological subtypes of KG4VS. This subclassification could predict short- and long-term facial nerve function after microsurgical resection of KG4VS via the retrosigmoid approach. The risk of postoperative facial palsy when attempting total resection is greater for type 4V than for type 4D. This classification into types 4V and 4D could help to predict the risk of facial nerve injury and generate more individualized surgical strategies for KG4VSs with better facial nerve outcomes.

  Jul. 2023, Journal of neurosurgery, 1 - 11, English, International magazine

  [Refereed]

  Scientific journal


• Intrasellar Chordoma Mimicking Pituitary Macroadenoma with Hyperprolactinemia and Hypopituitarism: Clinical Images with a Surgical Video.

  Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama

  A purely intrasellar chordoma is rare among skull base chordomas and is recognized as originating from ectopic embryological notochord located in the sella turcica. In view of its rarity and nonspecific symptoms, clinicians may misdiagnose intrasellar chordoma as pituitary adenoma based on preoperative radiographic images. In this report, we present an intrasellar chordoma that clinically mimicked pituitary macroadenoma with hyperprolactinemia and hypopituitarism and was successfully resected by endoscopic endonasal transsphenoidal surgery. This case demonstrated radiographic features that chordoma should be suspected in sellar lesions. The enlarged sellar with thinned remodeled bone without clival destruction was firstly reminiscent of pituitary adenoma, whereas the very high signal on T2-weighted images and heterogeneous enhancement characteristically suggested chordoma. This rare diagnosis must be considered in the preoperative evaluation of sellar lesions because it can affect how the neurosurgeon prepares for surgery and the surgical goals.

  Nov. 2022, World neurosurgery, 170, 158 - 162, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Presence of a fundal fluid cap on preoperative magnetic resonance imaging may predict long-term facial nerve function after resection of vestibular schwannoma via the retrosigmoid approach.

  Yuichi Fujita, Yoichi Uozumi, Takashi Sasayama, Eiji Kohmura

  OBJECTIVE: Preservation of neurological function is a priority when performing a resection of a vestibular schwannoma (VS). Few studies have examined the radiographic value of a fundal fluid cap-i.e., cerebrospinal fluid in the lateral end of a VS within the internal auditory canal-for prediction of postoperative neurological function. The aim of this study was to clarify whether the presence of a fundal fluid cap on preoperative magnetic resonance images has a clinical impact on facial nerve function after resection of VSs. METHODS: The presence of a fundal fluid cap and its prognostic impact on long-term postoperative facial nerve function were analyzed. RESULTS: A fundal fluid cap was present in 102 of 143 patients who underwent resection of sporadic VSs via the retrosigmoid approach. Facial nerve function was acceptable (House-Brackmann grade I-II) immediately after surgery in 82 (80.4%) patients with a fundal fluid cap and in 26 (63.4%) of those without this sign. The preservation rate of facial nerve function increased in a time-dependent manner after surgery in patients with a fundal fluid cap but plateaued by 3 months postoperatively in those without a fundal fluid cap; the difference was statistically significant at 12 months (96.1% vs 82.9%, p = 0.013) and 24 months (97.1% vs 82.9%, p = 0.006) after surgery. The presence of a fundal fluid cap had a significantly positive effect on long-term facial nerve function at 24 months after surgery when tumor size and intraoperative neuromonitoring response were taken into account (OR 5.55, 95% CI 1.12-27.5, p = 0.034). CONCLUSIONS: Neuromonitoring-guided microsurgery for total resection of VSs is more likely to be successful in terms of preservation of facial nerve function if a fundal fluid cap is present. This preoperative radiographic sign could be helpful when counseling patients and deciding the treatment strategy.

  Sep. 2022, Journal of neurosurgery, 138(4) (4), 1 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Symptom-Based Opioid-Free Treatment for Persistent Postoperative Headache After Vestibular Schwannoma Resection via the Retrosigmoid Approach.

  Yuichi Fujita, Yoichi Uozumi, Yoji Yamaguchi, Tomoaki Nakai, Takashi Sasayama, Eiji Kohmura

  OBJECTIVE: Postoperative headache (POH) is a disturbing complaint following vestibular schwannoma (VS) resection. However, there are currently no treatment guidelines. The aim of this study was to evaluate the usefulness of symptom-based opioid-free treatments for persistent POH following VS resection. METHODS: Of 137 patients whose sporadic VS was resected via the retrosigmoid approach, 74 had persistent POH beyond 3 postoperative months. Their symptoms were classified as tension-type headache (TTH), migraine, neuralgia, or other and were treated. We retrospectively analyzed the treatment outcomes during 2 postoperative years. RESULTS: Patients with persistent POH were significantly younger (P = 0.003) and had significantly smaller tumors (P = 0.001) and a greater extent of resection (P = 0.04) than those without POH. The most common simple symptom was TTH in 56 patients, followed by migraine in 6 and neuralgia in 5. All 7 patients with complex symptoms had a mixture of TTH and migraine. The complete disappearance of POH was achieved in 40 patients (54%) and a medication-free condition in 51 (69%). No patients had residual severe POH that could not be controlled with medication. Achievement of a medication-free outcome that included complete disappearance of the persistent POH was significantly more common in patients with preserved facial nerve function (P = 0.008) and those with simple symptoms (P < 0.001). CONCLUSION: The symptom-based approach is appropriate for understanding and managing persistent POH after VS resection with excellent pain control. Preserved facial nerve function and simple symptoms are significant prognostic factors for a medication-free outcome.

  Lead, Jun. 2022, World neurosurgery, 162, e347-e357, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Unilateral approach for bilateral middle cerebral artery aneurysms assisted by preoperative understandings of aneurysm wall properties:2-dimensional operative video.

  Hidehito Kimura, Kosuke Hayashi, Susumu Osaki, Ayaka Shibano, Yuichi Fujita, Hiroaki Nagashima, Akio Tomiyama, Takashi Sasayama

  Mar. 2022, World neurosurgery, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery.

  Mitsuru Hashiguchi, Kazuhiro Tanaka, Hiroaki Nagashima, Yuichi Fujita, Hirotomo Tanaka, Masaaki Kohta, Tomoaki Nakai, Yoichi Uozumi, Masahiro Maeyama, Yuichiro Somiya, Eiji Kohmura, Takashi Sasayama

  OBJECTIVE: Epilepsy in glioblastoma patients significantly reduces their quality of life; however, little is known about the association between predicting epilepsy and metabolites in tumors. In this study, we used 3.0-T magnetic resonance imaging and 1H-magnetic resonance spectroscopy (MRS) to quantify metabolite concentrations in patients with varying epilepsy histories. METHODS: Fifty-one patients with glioblastoma underwent pretreatment 3.0-T MRI/1H-MRS scanning. Single-voxel (1.5 cm3) MRS, in an enhanced lesion, was acquired using a double-echo point-resolved spectroscopic sequence with chemical-shift selective water suppression. MRS data were quantified with linear combination model (LC-Model) software. We compared the MRS data between groups with and without epilepsy during the postoperative course (EP). RESULTS: The ratios of glutamate (Glu) and glutamate + glutamine (Glx) to total creatine (Glu/tCr and Glx/tCr) in the tumor were associated with epilepsy history. The receiver operating characteristic curve analysis showed that a Glu/tCr value of 1.81 was 70% sensitive and 90% specific for the prediction of EP (area under curve: 0.82). In the analysis excluding patients with preoperative epilepsy, a Glu/tCr value of 1.81 was 75% sensitive and 88% specific for the prediction (area under curve: 0.87). CONCLUSIONS: Intratumoral metabolite concentrations measured using pretreatment 3.0-T MRI/1H-MRS changed characteristically in the group with EP. Our study suggests that the Glu/tCr ratio in tumors has adequate reliability in predicting EP. Pretreatment MRS is a minimally invasive and simple procedure that can provide useful information on glioblastoma patients.

  Jan. 2022, World neurosurgery, 160, e501-e510, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of a High-definition Three-dimensional Exoscope in Simultaneous Transcranial and Endoscopic Endonasal Surgery: A Case Report.

  Ayaka Shibano, Hidehito Kimura, Shun Tatehara, Tatsuya Furukawa, Kazuki Inoue, Yuichi Fujita, Hiroaki Nagashima, Shunsuke Yamanishi, Tadashi Nomura, Ken-Ichi Nibu, Takashi Sasayama

  Owing to recent advances in medical optical technology, a high-definition (4K) three-dimensional (3D) exoscope has been developed as an alternative tool to using conventional microscopes for microscopic surgery, and its efficacy for neurosurgery has been reported. We report a case who underwent simultaneous surgery aiming for en bloc resection of an anterior skull base malignancy with concurrent exoscopic transcranial and endoscopic endonasal approaches using a 4K 3D exoscope. The patient was a 76-year-old woman who underwent en bloc resection for an anterior skull base olfactory neuroblastoma 13 years ago. After confirming the recurrence of progressive olfactory neuroblastoma, tumor resection was again decided to be performed. As with the first procedure, surgery was performed in an en bloc manner, using both transcranial and endonasal approaches. Exoscope provided enough space above the surgical field to allow us to perform transcranial and endonasal surgeries simultaneously. Moreover, the surgeons could maintain a comfortable posture throughout the procedure, and total tumor removal was successfully achieved without any abnormal event. To our knowledge, this is the first report of the introduction of an exoscope aiming for en bloc resection of an anterior skull base malignancy while performing simultaneous surgery with both transcranial and endonasal approaches. We believe that the more cases are accumulated, the more efficacy of a 4K 3D exoscope will be elucidated.

  2022, NMC case report journal, 9, 243 - 247, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Hyperintense signal on diffusion-weighted imaging for monitoring the acute response and local recurrence after photodynamic therapy in malignant gliomas.

  Yuichi Fujita, Hiroaki Nagashima, Kazuhiro Tanaka, Mitsuru Hashiguchi, Tomoo Itoh, Takashi Sasayama

  PURPOSE: Photodynamic therapy (PDT) subsequent to surgical tumor removal is a novel localized treatment for malignant glioma that provides effective local control. The acute response of malignant glioma to PDT can be detected as linear transient hyperintense signal on diffusion-weighted imaging (DWI) and a decline in apparent diffusion coefficient values without symptoms. However, their long-term clinical significance has not yet been examined. The aim of this study was to clarify the link between hyperintense signal on DWI as an acute response and recurrence after PDT in malignant glioma. METHODS: Thirty patients (16 men; median age, 60.5 years) underwent PDT for malignant glioma at our institution between 2017 and 2020. We analyzed the signal changes on DWI after PDT and the relationship between these findings and the recurrence pattern. RESULTS: All patients showed linear hyperintense signal on DWI at the surface of the resected cavity from day 1 after PDT. These changes disappeared in about 30 days without any neurological deterioration. During a mean post-PDT follow-up of 14.3 months, 19 patients (63%) exhibited recurrence: 10 local, 1 distant, and 8 disseminated. All of the local recurrences arose from areas that did not show hyperintense signal on DWI obtained on day 1 after PDT. CONCLUSIONS: The local recurrence in malignant glioma after PDT occurs in an area without hyperintense signal on DWI as an acute response to PDT. This characteristic finding could aid in the monitoring of local recurrence after PDT.

  Sep. 2021, Journal of neuro-oncology, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Newly Identified Hemodynamic Parameter to Predict Thin-Walled Regions of Unruptured Cerebral Aneurysms Using Computational Fluid Dynamics Analysis.

  Hidehito Kimura, Susumu Osaki, Kosuke Hayashi, Masaaki Taniguchi, Yuichi Fujita, Takeshi Seta, Akio Tomiyama, Takashi Sasayama, Eiji Kohmura

  BACKGROUND: The thin-walled regions (TIWRs) of intracranial aneurysms have a high risk of rupture during surgical manipulation. They have been reported to be predicted by wall shear stress and pressure (PS) based on computational fluid dynamics analysis, although this remains controversial. In this study, we investigated whether the oscillatory shear index (OSI) can predict TIWRs. METHODS: Twenty-five unruptured aneurysms were retrospectively analyzed; the position and orientation of the computational fluid dynamics color maps were adjusted to match the intraoperative micrographs. The red area on the aneurysm wall was defined as TIWR, and if most of the regions on the color map corresponding to TIWR were OSI low (lower quartile range), time-averaged wall shear stress (TAWSS) high, or PS high (upper quartile range), each region was defined as a matched region and divided by the total number of TIWRs to calculate the match rate. In addition, the mean values of OSI, TAWSS, and PS corresponding to TIWRs were quantitatively compared with those in adjacent thick-walled regions. RESULTS: Among 27 TIWRs of 25 aneurysms, 23, 10, and 14 regions had low OSI, high TAWSS, and high PS regions (match rate: 85.2%, 37.0%, and 51.9%), respectively. Receiver operating characteristic curve analysis demonstrated that OSI was the most effective hemodynamic parameter (area under the curve, 0.881), followed by TAWSS (0.798). Multivariate analysis showed that OSI was a significant independent predictor of TIWRs (odds ratio, 18.30 [95% CI, 3.2800-102.00], P < 0.001). CONCLUSIONS: OSI may be a unique predictor for TIWRs. Low OSI strongly corresponds with TIWRs of intracranial aneurysms.

  Aug. 2021, World neurosurgery, 152, e377-e386, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The Histopathologic and Radiologic Features of T2-FLAIR Mismatch Sign in IDH-Mutant 1p/19q Non-codeleted Astrocytomas.

  Yuichi Fujita, Hiroaki Nagashima, Kazuhiro Tanaka, Mitsuru Hashiguchi, Takanori Hirose, Tomoo Itoh, Takashi Sasayama

  OBJECTIVE: The T2-FLAIR mismatch sign is a useful imaging sign in clinical magnetic resonance imaging studies for detecting isocitrate dehydrogenase (IDH)-mutant 1p/19q non-codeleted astrocytomas. However, the association between the mismatch sign and pathologic findings is poorly understood. Therefore, the aim of this study was to elucidate the relationship of histopathologic and radiologic features with the mismatch sign in IDH-mutant 1p/19q non-codeleted astrocytomas. METHODS: We divided 17 IDH-mutant 1p/19q non-codeleted patients into 2 groups according to mismatch sign presence (WITH, n = 9; WITHOUT, n = 8) and retrospectively analyzed their pathologic findings and apparent diffusion coefficient (ADC) values. We also compared these findings between the tumor Core (central area) and Rim (marginal area). RESULTS: In the pathologic analysis, Core of the WITH group contained numerous microcysts whereas Rim had abundant neuroglial fibrils and cellularity. In contrast, Core of the WITHOUT group had highly concentrated neuroglial fibrils. In ADC analysis, Core of the WITH group had significantly higher ADC values compared with Rim (P < 0.001). However, there was no significant difference between Core and Rim in the WITHOUT group (P = 0.12). The WITH group had a significantly higher Core/Rim ratio of ADC values compared with the WITHOUT group (P < 0.001). CONCLUSIONS: This study provides evidence that a region-dependent microstructural difference could reflect the mismatch sign in IDH-mutant 1p/19q non-codeleted astrocytomas. Core of the mismatch sign characteristically had microcystic changes accompanied by higher ADC values, whereas Rim had abundant neuroglial fibrils and cellularity accompanied by lower ADC values.

  Lead, Feb. 2021, World neurosurgery, 149, e253-e260, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Glioma cells require one-carbon metabolism to survive glutamine starvation.

  Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura

  Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and clinical resistance. However, less is known about how cancer cells exhibit metabolic flexibility to sustain cell growth and survival from nutrient starvation. Here, we find that serine and glycine levels were higher in low-nutrient regions of tumors in glioblastoma multiforme (GBM) patients than they were in other regions. Metabolic and functional studies in GBM cells demonstrated that serine availability and one-carbon metabolism support glioma cell survival following glutamine deprivation. Serine synthesis was mediated through autophagy rather than glycolysis. Gene expression analysis identified upregulation of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to regulate one-carbon metabolism. In clinical samples, MTHFD2 expression was highest in the nutrient-poor areas around "pseudopalisading necrosis." Genetic suppression of MTHFD2 and autophagy inhibition caused tumor cell death and growth inhibition of glioma cells upon glutamine deprivation. These results highlight a critical role for serine-dependent one-carbon metabolism in surviving glutamine starvation and suggest new therapeutic targets for glioma cells adapting to a low-nutrient microenvironment.

  Jan. 2021, Acta neuropathologica communications, 9(1) (1), 16 - 16, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model.

  Masahiro Maeyama, Kazuhiro Tanaka, Masamitsu Nishihara, Yasuhiro Irino, Masakazu Shinohara, Hiroaki Nagashima, Hirotomo Tanaka, Satoshi Nakamizo, Mitsuru Hashiguchi, Yuichi Fujita, Masaaki Kohta, Eiji Kohmura, Takashi Sasayama

  The ketogenic diet (KD) is a high fat and low carbohydrate diet that produces ketone bodies through imitation of starvation. The combination of KD and Bevacizumab (Bev), a VEGF inhibitor, is considered to further reduce the supply of glucose to the tumor. The metabolite changes in U87 glioblastoma mouse models treated with KD and/or Bev were examined using gas chromatography-mass spectrometry. The combination therapy of KD and Bev showed a decrease in the rate of tumor growth and an increase in the survival time of mice, although KD alone did not have survival benefit. In the metabolome analysis, the pattern of changes for most amino acids are similar between tumor and brain tissues, however, some amino acids such as aspartic acid and glutamic acid were different between tumors and brain tissues. The KD enhanced the anti-tumor efficacy of Bev in a glioblastoma intracranial implantation mouse model, based on lowest levels of microvascular density (CD31) and cellular proliferation markers (Ki-67 and CCND1) in KD + Bev tumors compared to the other groups. These results suggested that KD combined with Bev may be a useful treatment strategy for patients with GBM.

  Jan. 2021, Scientific reports, 11(1) (1), 79 - 79, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Acute Occlusion of the Ventriculoperitoneal Shunt Due to Factor XIII Deficiency-related Postoperative Hemorrhage: A Case Report

  Shunsuke YAMANISHI, Hidehito KIMURA, Hideya HAYASHI, Yoji YAMAGUCHI, Yuichi FUJITA, Tomoaki NAKAI, Yoichi UOZUMI, Yoshio KATAYAMA, Masaaki TANIGUCHI, Takashi SASAYAMA

  Japan Neurosurgical Society, 2021, NMC Case Report Journal, 8(1) (1), 573 - 577

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• En Bloc Subtotal Temporal Bone Resection in a Case of Advanced Ear Cancer: 2-Dimensional Operative Video.

  Hidehito Kimura, Masaaki Taniguchi, Hirotaka Shinomiya, Masanori Teshima, Yuichi Fujita, Kazunobu Hashikawa, Ken-Ichi Nibu, Eiji Kohmura

  Temporal bone cancer is extremely rare; thus, the optimal surgical strategy for advanced tumors, en bloc vs piecemeal resection, remain controversial. Some authors have favored piecemeal resection and reported comparable outcomes.1 Other authors recommend the use of en bloc subtotal temporal bone resection (STBR) for advanced tumors and reported better outcomes, although long-term cancer control remains uncertain.2 Because of the technical difficulty and the lack of demonstrative surgical videos, STBR has not been sufficiently distributed. This video demonstrates en bloc STBR in a stepwise manner with particular focus on the neurosurgeon's role and aims to improve its safety, feasibility, and distribution. This video conforms to the description of Osawa et al3 in the designations for each segment of the petrous ICA. A 67-yr-old man suffered from consistent otorrhea and underwent tympanoplasty at an outside hospital 1 yr earlier. Following a histopathological diagnosis of squamous cell carcinoma in the specimen, he underwent chemoradiotherapy (cisplatin + 70 Gy). However, a current imaging revealed a recurrent tumor and he was admitted to our hospital for radical resection. Computed tomography revealed a disrupted external auditory canal and magnetic resonance imaging indicated a carcinoma equivalent to Pittsburg stage T3. The patient underwent radical STBR without complications. His postoperative course was uneventful. At 2 yr postoperative, his modified Rankin scale score was 1, no recurrence was noted, and his facial nerve function was restored to House-Brackmann Grade IV. This video was reproduced with informed consent from the patient.

  Sep. 2020, Operative neurosurgery (Hagerstown, Md.), 19(4) (4), E402-E403, English, International magazine

  [Refereed]

  Scientific journal


• Multi-marker algorithms based on CXCL13, IL-10, sIL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose CNS lymphoma.

  Masahiro Maeyama, Takashi Sasayama, Kazuhiro Tanaka, Satoshi Nakamizo, Hirotomo Tanaka, Masamitsu Nishihara, Yuichi Fujita, Kenji Sekiguchi, Masaaki Kohta, Katsu Mizukawa, Takanori Hirose, Tomoo Itoh, Eiji Kohmura

  Tumor biopsy is essential for the definitive diagnosis of central nervous system (CNS) lymphoma. However, the biopsy procedure carries the risk of complications such as bleeding, convulsions, and infection. Cerebrospinal fluid (CSF) β2-microglobulin (β2-MG), soluble IL-2 receptor (sIL-2R), and interleukin-10 (IL-10) are known to be useful diagnostic biomarkers for CNS lymphoma. The C-X-C motif chemokine ligand 13 (CXCL13) was recently reported to be another useful biomarker for CNS lymphoma. The purpose of this study is to establish a diagnostic algorithm that can avoid biopsy by combining these diagnostic biomarkers. In the first, we conducted a case-control study (n = 248) demonstrating that the CSF CXCL13 concentration was significantly increased in CNS lymphoma patients compared with various other brain diseases (AUC = 0.981). We established a multi-marker diagnostic model using CSF CXCL13, IL-10, β2-MG, and sIL-2R from the results of the case-control study and then applied the model to a prospective study (n = 104) to evaluate its utility. The multi-marker diagnostic algorithms had excellent diagnostic performance: the sensitivity, specificity, positive predictive value, and negative predictive value were 97%, 97%, 94%, and 99%, respectively. In addition, CSF CXCL13 was a prognostic biomarker for CNS lymphoma patients. Our study suggests that multi-marker algorithms are important diagnostic tools for patients with CNS lymphoma.

  Jun. 2020, Cancer medicine, 9(12) (12), 4114 - 4125, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intraoperative 3-T Magnetic Resonance Spectroscopy for Detection of Proliferative Remnants of Glioma.

  Yuichi Fujita, Masaaki Kohta, Takashi Sasayama, Kazuhiro Tanaka, Mitsuru Hashiguchi, Hiroaki Nagashima, Katsusuke Kyotani, Tomoaki Nakai, Tomoo Ito, Eiji Kohmura

  BACKGROUND: Few studies have examined the usefulness of intraoperative magnetic resonance spectroscopy (iMRS) for identifying abnormal signals at the resection margin during glioma surgery. The aim of this study was to assess the value of iMRS for detecting proliferative remnants of glioma at the resection margin. METHODS: Fifteen patients with newly diagnosed glioma underwent single-voxel 3-T iMRS concurrently with intraoperative magnetic resonance imaging-assisted surgery. Volumes of interest (VOIs) were placed at T2-hyperintense or contrast-enhancing lesions at the resection margin. In addition to technical verification, the correlation between the MIB-1 labeling index (a pathologic feature) and metabolites measured using iMRS (N-acetyl-L-aspartate [NAA], choline [Cho], and Cho/NAA ratio) was analyzed. RESULTS: iMRS was performed for 20 VOIs in 15 patients. Fourteen (70%) of these VOIs were confirmed to be MIB-1-positive. There was a significant positive correlation between the Cho/NAA ratio and MIB-1 index (r = 0.46, P = 0.04). Cho level (P = 0.003) and Cho/NAA ratio (P = 0.002) were significantly higher in VOIs that were MIB-1-positive than in those that were MIB-1-negative. Detection of a Cho level >1.074 mM and a Cho/NAA ratio >0.48 using iMRS resulted in high diagnostic accuracy for MIB-1-positive remnants (Cho level: sensitivity 86%, specificity 100%; Cho/NAA ratio: sensitivity 79%, specificity 100%). CONCLUSIONS: This study provides evidence that 3-T iMRS can detect proliferative remnants of glioma at the resection margin using the Cho level and Cho/NAA ratio, suggesting that intraoperative magnetic resonance imaging-assisted surgery with iMRS would be practicable in glioma.

  Lead, May 2020, World neurosurgery, 137, 149 - 157, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• DWI for Monitoring the Acute Response of Malignant Gliomas to Photodynamic Therapy.

  Y Fujita, T Sasayama, K Tanaka, K Kyotani, H Nagashima, M Kohta, H Kimura, A Fujita, E Kohmura

  BACKGROUND AND PURPOSE: Photodynamic therapy is a novel treatment that provides effective local control, but little is known about photodynamic therapy-induced changes on MR imaging. The aim of this study was to assess the utility of DWI and ADC in monitoring the response of malignant gliomas to photodynamic therapy. MATERIALS AND METHODS: Time-dependent changes in DWI and ADC values after photodynamic therapy were analyzed in a group that received photodynamic therapy in comparison with a group that did not. RESULTS: Twenty-four patients were enrolled (photodynamic therapy, n = 14; non-photodynamic therapy, n = 10). In all patients who received photodynamic therapy, linear high signals on DWI in the irradiated area were detected adjacent to the resection cavity and were 5-7 mm in depth from 1 day posttreatment and disappeared in about 30 days without any neurologic deterioration. The non-photodynamic therapy group did not show this change. The photodynamic therapy group had significantly lower ADC values from 1 day posttreatment (P < .001), which increased steadily and disappeared by 30 days. There was no decline or time-dependent change in ADC values in the non-photodynamic therapy group. CONCLUSIONS: The acute response of malignant gliomas to photodynamic therapy was detected as linear high signals on DWI and as a decrease in ADC values. These findings were asymptomatic and transient. Although the photodynamic therapy-induced acute response on MR imaging disappeared after approximately 30 days, it may be helpful for confirming the photodynamic therapy-irradiated area.

  Lead, Dec. 2019, AJNR. American journal of neuroradiology, 40(12) (12), 2045 - 2051, English, International magazine

  [Refereed]

  Scientific journal


• Tumor-associated macrophage related interleukin-6 in cerebrospinal fluid as a prognostic marker for glioblastoma.

  Tatsuo Hori, Takashi Sasayama, Kazuhiro Tanaka, Yu-Ichiro Koma, Masamitsu Nishihara, Hirotomo Tanaka, Satoshi Nakamizo, Hiroaki Nagashima, Masahiro Maeyama, Yuichi Fujita, Hiroshi Yokozaki, Takanori Hirose, Eiji Kohmura

  Interleukin-6 (IL-6) is one of the pleiotropic cytokines and has received attention as a critical factor implicated in the invasion and the angiogenesis of various cancers. In glioma, IL-6 is known to be associated with the prognosis; however, the roles of IL-6 in cerebrospinal fluid (CSF) has not been studied sufficiently. We examined the concentration of CSF IL-6 using 75 CSF samples of glioma (54 glioblastomas (GBMs) and 21 other grades of gliomas) and analyzed the association CSF IL-6 with infiltration levels of tumor-associated macrophages (TAMs) and prognosis. The concentration of CSF IL-6 in GBM patients was significantly higher than that in other grades of gliomas. CSF IL-6 levels were associated with the infiltration rate of TAMs in GBMs, and IL-6 levels were increased in the GBM cells co-cultured with TAM-like macrophages. The CSF of GBM patients, which contained high concentration of IL-6, promoted the migration ability of GBM cells, and neutralization antibodies of IL-6 inhibited its migration ability. Finally, in both univariate and multivariate analysis, higher CSF IL-6 levels were associated with poorer prognosis in GBM patients. These results indicated that the concentration of CSF IL-6 is associated with TAMs' infiltration level and may be a useful prognostic biomarker for the GBM patients.

  Oct. 2019, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 68, 281 - 289, English, International magazine

  [Refereed]

  Scientific journal


• Application of a Minimally Invasive Liposuction Technique for Harvesting Fat during Transsphenoidal Surgery: A Technical Note.

  Yuichi Fujita, Masaaki Taniguchi, Takashi Tsuzuki, Tomoaki Nakai, Yoichi Uozumi, Hidehito Kimura, Eiji Kohmura

  Secure reconstruction in transsphenoidal surgery (TSS) is important for the prevention of the major and serious complication of postoperative cerebrospinal fluid (CSF) leak. Although abdominal fat can be safely and effectively used as a reconstruction tissue, harvesting it from the abdominal wall is traumatic and invasive, resulting in cosmetic problems. In this report, we present a method of harvesting abdominal fat using a minimally invasive liposuction technique to avoid cosmetic issues. Since 2016, we have been using fat harvested from the abdominal wall by suctioning with a dedicated syringe for reconstruction after TSS in selected cases. The liquefied fat obtained by the liposuction technique was wrapped with an oxycellulose sheet and changed its form to what we termed "fatty candy". In this form, the fat maintained its configuration and could be handled almost as easily as a conventional fat graft. In our experienced series, there was no case with wound complication nor postoperative or late-onset CSF leak during a postoperative follow-up of at least 3 months. The fat harvested by this simple and minimally invasive liposuction technique can be expected to provide an autologous graft that is adequate not only for prevention of cosmetic problems but also for prevention of postoperative CSF leak.

  Lead, May 2019, Neurologia medico-chirurgica, 59(5) (5), 184 - 190, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clear Detection of Thin-Walled Regions in Unruptured Cerebral Aneurysms by Using Computational Fluid Dynamics.

  Hidehito Kimura, Masaaki Taniguchi, Kosuke Hayashi, Yosuke Fujimoto, Yuichi Fujita, Takashi Sasayama, Akio Tomiyama, Eiji Kohmura

  OBJECTIVE: Thin-walled regions (TIWRs) within cerebral aneurysms have a high risk of rupture during surgical manipulation. Previous reports have demonstrated specific changes in the parameters of computational fluid dynamics in TIWRs; however, they have not been fully evaluated. We identified and investigated a novel parameter, wall shear stress vector cycle variation (WSSVV), with user-friendly software that could predict TIWRs. METHODS: Twelve unruptured cerebral aneurysms were analyzed. TIWRs were defined as reddish areas compared with the normal-colored parent artery on intraoperative views. The position and orientation of these clinical images were adjusted to match the WSSVV color maps. TIWRs and thick-walled regions (TKWRs) were marked and compared with the corresponding regions on WSSVV maps. The default images obtained from WSSVV imaging required appropriate maximum color bar value (MCBV) adjustment for predicting TIWRs. Sensitivity and specificity analyses were performed by changing the MCBV from 300 to 700 at intervals of 100. With the optimal MCBV, the WSSVV values were quantitatively compared. RESULTS: All of the selected 18 TIWRs and 16 TKWRs corresponded to low- and high-value regions of the WSSVV color maps at the adjusted MCBV, respectively. The mean optimal MCBV was 483.3 ± 167.50 (range, 300-700). According to receiver operating characteristic analysis, the best MCBV for predicting TIWRs was 500 (highest sensitivity, 0.89; specificity, 0.94). Under this condition, the quantitative values of the computational fluid dynamics color maps for TIWRs and TKWRs were significantly different (P < 0.01). CONCLUSIONS: Low WSSVV values may indicate TIWRs within cerebral aneurysms.

  Jan. 2019, World neurosurgery, 121, e287-e295, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 脊髄係留症候群による疼痛に対してspinal cord stimulation(SCS)を併用した1例

  森下 暁二, 相原 英夫, 長嶋 宏明, 藤田 祐一, 松尾 和哉, 小山 淳二

  (一社)日本定位・機能神経外科学会, Dec. 2018, 機能的脳神経外科, 57, 25 - 29, Japanese

  [Refereed]


• [Clinical Features and Treatment Strategy of Vertebral Artery Injury Associated with Cervical Spine Trauma].

  Yuichi Fujita, Hideo Aihara, Hiroaki Nagashima, Akitsugu Morishita, Kenji Aoki, Hiroyuki Takayama, Toshihiko Harada, Yoshiki Tohma, Yoshie Hara, Eiji Kohmura

  OBJECTIVE: Vertebral artery injury(VAI)associated with cervical spine trauma has the potential to cause catastrophic vertebrobasilar stroke. However, there are no well-defined treatment recommendations for VAI. The purpose of this study was to identify an effective treatment strategy for VAI following cervical spine trauma. METHODS: Ninety-seven patients with blunt cervical spine trauma were treated at Hyogo Prefectural Kakogawa Medical Center between January 2013 and September 2017. Of these patients, 49 underwent computed tomographic angiography or magnetic resonance angiography for evaluation of the vertebral artery. Eighteen patients(36.7%)had a diagnosis of VAI. We retrospectively analyzed the clinical features, treatment, and outcomes in these 18 patients. RESULTS: Seven patients(38.9%)had bilateral VAI, 16(88.9%)had cervical dislocation, and 2(11.1%)had transverse process fractures extending into the transverse foramen. Surgical reduction was performed in 14 patients. Five patients with either bilateral or unilateral occlusion underwent parent artery occlusion before reduction. There were no complications after this procedure. Two patients with bilateral VAI had a stroke before treatment. There were no infarctions in the distribution of the vertebrobasilar artery after intervention. The perioperative stroke rate was relatively good, and almost all Glasgow Outcome Scale scores were related to the degree of spinal cord injury. CONCLUSIONS: Aggressive screening for VAI is important in patients with cervical spine trauma in order to ensure adequate treatment. Although the treatment strategy described here could yield good results, it may require modification according to the needs of the individual patient.

  Aug. 2018, No shinkei geka. Neurological surgery, 46(8) (8), 663 - 671, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• Endoscopic endonasal surgery for pituitary adenomas extending to the oculomotor cistern.

  Masaaki Taniguchi, Tomoaki Nakai, Hidehito Kimura, Yuichi Fujita, Yoichi Uozumi, Masaaki Kohta, Eiji Kohmura

  BACKGROUND: Extension of a pituitary adenoma to the oculomotor cistern harbors the risk of oculomotor nerve impairment and further extension into the interpeduncular cistern. The role of endoscopic endonasal surgery for those lesions was investigated. METHODS: The medical records were retrospectively analyzed. Attention was paid to the oculomotor nerve function and removal rate of the tumor within the oculomotor and interpeduncular cisterns. RESULTS: Six patients were eligible for the study, including 2 with oculomotor nerve palsy. The tumor from the oculomotor and interpeduncular cistern was removed in all except on one side of the case with bilateral tumor extension. The oculomotor nerve palsy demonstrated partial recovery in both cases during the 3-month follow-up. CONCLUSION: The pituitary adenoma extending to the oculomotor cistern can be removed under the endoscope. Improvement of oculomotor nerve palsy can be achieved, and further tumor extension into the interpeduncular cistern can be prevented.

  Mar. 2018, Head & neck, 40(3) (3), 536 - 543, English, International magazine

  [Refereed]

  Scientific journal


• [A Case of Transoral Penetrating Head Injury from a Crossbow-Fired Arrow].

  Naoto Nakamura, Yuichi Fujita, Satoshi Nakamizo, Yoshio Sakagami, Ken Okazaki, Kouta Kida

  Penetrating head injuries are extremely rare in Japan. The authors describe a case involving a penetrating head injury from an arrow fired from a crossbow. A 52-year-old man who had shot himself transorally in a suicide attempt was admitted to the authors' hospital. On admission, he was conscious and exhibited no neurological deficits. The end of the arrow was visible inside his oral cavity. Computed tomography revealed the arrow had penetrated the right cerebellum and occipital lobe, resulting in a very small hematoma. Digital subtraction angiography revealed no significant vascular injuries. After considering these findings and the nature of the object, the authors decided to remove the arrow from the cranium by pulling it from the patient's oral cavity. To remove the arrow, surgery was performed with several devices, including intraoperative X-ray, endoscopy, and intraoperative angiography. The authors were able to completely remove the arrow, and the patient experienced no new deficits, except mild ataxia and mild dysphasia, and no signs of cerebral infection or cerebrospinal fluid leakage after the surgery. Although most cases of penetrating head injuries require craniotomies, the authors were able to safely remove the foreign object in this case without performing a craniotomy. Because guidelines for the treatment of penetrating head injuries have not been established, the treatment of each case must be modified according to the nature of the foreign object and the findings of preoperative imaging techniques.

  Sep. 2017, No shinkei geka. Neurological surgery, 45(9) (9), 799 - 804, Japanese, Domestic magazine

  [Refereed]

  Scientific journal


• 高齢化地域における80歳以上のくも膜下出血の臨床像と治療成績

  藤田 祐一, 阪上 義雄, 中溝 聡, 中村 直人

  (一社)日本脳卒中学会, May 2017, 脳卒中, 39(3) (3), 184 - 189, Japanese

  [Refereed]


• Rapid tumor growth with glial differentiation of central neurocytoma after stereotactic radiosurgery.

  Hirotomo Tanaka, Takashi Sasayama, Haruo Yamashita, Yoshie Hara, Shigeto Hayashi, Yusuke Yamamoto, Yuichi Fujita, Takeshi Okino, Takashi Mizowaki, Yoji Yamaguchi, Kazuhiro Tanaka, Eiji Kohmura

  Although stereotactic radiosurgery (SRS) is effective for central neurocytoma (CN), the long-term outcome of SRS remains unclear. We present a case of recurrent CN that was diagnosed 10years after surgical resection and consecutive stereotactic radiotherapy. The patient was treated with SRS for the recurrent tumor, but underwent two-staged surgery once again due to rapid tumor growth. Histological features of the recurrent tumor were consistent with the diagnosis of CN. However, an increased Ki-67 proliferation index (3.4%), aberrant angiogenesis and glial differentiation of the tumor cells were observed, which were not identified in the initial CN. In addition, vascular endothelial growth factor (VEGF) and VEGF receptor were highly expressed in the recurrent tumor cells, as well as in the vascular endothelial cells. Our case suggests that malignant transition with aberrant angiogenesis and glial differentiation may be attributable to SRS.

  Sep. 2016, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 31, 188 - 92, English, International magazine

  [Refereed]

  Scientific journal


• Castleman病を伴う小児第3脳室内chordoid meningiomaの1例

  藤田 祐一, 長嶋 達也, 河村 淳史, 阿久津 宣行, 山元 一樹

  (一社)日本小児神経外科学会, May 2015, 小児の脳神経, 39(5) (5), 347 - 353, Japanese

  [Refereed]


• 減圧開頭術後に対側頭蓋内血腫が出現または増大し手術を要した重症頭部外傷6例

  藤田 祐一, 山下 晴央, 林 成人, 山本 祐輔, 田中 宏和, 原 淑恵, 甲村 英二

  日本脳神経外科コングレス, Apr. 2015, 脳神経外科ジャーナル, 24(4) (4), 253 - 259, Japanese

  [Refereed]


• 【80歳以上のくも膜下出血】80歳以上のくも膜下出血症例に対する治療成績

  原 淑恵, 山下 晴央, 林 成人, 井上 悟志, 田中 宏知, 藤田 祐一

  (一社)日本脳卒中の外科学会, Sep. 2014, 脳卒中の外科, 42(5) (5), 336 - 339, Japanese

  [Refereed]


• 他疾患で集中治療中に発覚した頸動脈狭窄症にCASを行った2症例

  原 淑恵, 山下 晴央, 林 成人, 田中 宏知, 山本 祐輔, 藤田 祐一, 甲村 英二

  (NPO)日本脳神経血管内治療学会, Nov. 2013, JNET: Journal of Neuroendovascular Therapy, 7(6) (6), 368 - 368, Japanese

  [Refereed]

• 脳腫瘍診断におけるliquid biopsyの可能性 グリオーマおよび中枢神経悪性リンパ腫患者の髄液中炎症性マーカーと予後

  篠山 隆司, 田中 一寛, 長嶋 宏明, 藤田 祐一, 岩橋 洋文, 小松 正人, 児玉 良典, 伊藤 智雄, 廣瀬 隆則

  日本脳腫瘍病理学会, May 2023, Brain Tumor Pathology, 40(Suppl.) (Suppl.), 068 - 068, Japanese


• 副鼻腔腫瘍として発見された下垂体腺腫の一例

  神澤 真紀, 藤田 祐一, 坂東 弘教

  (一社)日本内分泌学会, Mar. 2023, 日本内分泌学会雑誌, 98(5) (5), 1624 - 1624, Japanese


• 脳腫瘍のsurrogate marker グリオーマおよび中枢神経悪性リンパ腫患者の髄液中炎症性マーカーの比較検討

  篠山 隆司, 田中 一寛, 長嶋 宏明, 藤田 祐一, 岩橋 洋文, 小松 正人, 児玉 良典, 伊藤 智雄, 廣瀬 隆則

  日本脳腫瘍病理学会, May 2022, Brain Tumor Pathology, 39(Suppl.) (Suppl.), 063 - 063, Japanese


• 組織診断に難渋した高齢infratentorial IDH-mutant high-grade astrocytomaの1例

  長嶋 宏明, 芝野 綾香, 藤田 祐一, 山川 皓, 田中 一寛, 太田 耕平, 小松 正人, 廣瀬 隆則, 伊藤 智雄, 篠山 隆司

  日本脳腫瘍病理学会, May 2022, Brain Tumor Pathology, 39(Suppl.) (Suppl.), 088 - 088, Japanese


• 頭蓋内に多発病変を認めたRosai-Dorfman病の1例

  田中 一寛, 梅田 昴, 小松 正人, 長嶋 宏明, 藤田 祐一, 岩橋 洋文, 伊藤 智雄, 篠山 隆司

  日本脳腫瘍病理学会, May 2022, Brain Tumor Pathology, 39(Suppl.) (Suppl.), 123 - 123, Japanese


• 2-HYDROXYGLUTARATE MAGNETIC RESONANCE SPECTROSCOPY IN ADULT BRAINSTEM GLIOMA PATIENTS

  Hiroaki Nagashima, Kazuhiro Tanaka, Yuichi Fujita, Mitsuru Hashiguchi, Mashahiro Maeyama, Yuichiro Somiya, Takanori Hirose, Tomoo Itoh, Takashi Sasayama

  Nov. 2021, NEURO-ONCOLOGY, 23, 131 - 131, English

  Summary international conference


• GLIOMA CELLS REPROGRAM SERINE-DEPENDENT ONE-CARBON METABOLISM TO SURVIVE GLUTAMINE STARVATION

  Kazuhiro Tanaka, Hiroaki Nagashima, Yuichi Fujita, Mitsuru Hashiguchi, Takashi Sasayama

  Nov. 2021, NEURO-ONCOLOGY, 23, 202 - 202, English

  Summary international conference


• 膠芽腫摘出術での脳室開放は播種を促進するか?

  篠山 隆司, 田中 一寛, 長嶋 宏明, 藤田 祐一, 岩橋 洋文, 橋口 充, 西原 賢在

  (一社)日本癌治療学会, Oct. 2021, 日本癌治療学会学術集会抄録集, 59回, P38 - 7, English


• 脳腫瘍遺伝子異常の画像診断 MR Spectroscopyを用いた2HG測定による成人脳幹グリオーマの遺伝子診断

  長嶋 宏明, 田中 一寛, 橋口 充, 藤田 祐一, 前山 昌博, 曽宮 雄一郎, 廣瀬 隆則, 伊藤 智雄

  日本脳腫瘍病理学会, May 2021, Brain Tumor Pathology, 38(Suppl.) (Suppl.), 060 - 060, Japanese


• グリオーマと栄養飢餓環境 グルタミン飢餓におけるセリン合成と一炭素代謝の調整

  田中 一寛, 長嶋 宏明, 宇野 滝子, 橘田 明音, 藤田 祐一, 橋口 充, 廣瀬 隆則, 伊藤 智雄, 篠山 隆司

  日本脳腫瘍病理学会, May 2021, Brain Tumor Pathology, 38(Suppl.) (Suppl.), 086 - 086, Japanese


• 悪性脳腫瘍に対する光線力学療法の現状と課題

  篠山 隆司, 田中 一寛, 藤田 祐一, 橋口 充, 坂田 純一, 甲田 将章, 谷口 理章

  (一社)日本癌治療学会, Oct. 2020, 日本癌治療学会学術集会抄録集, 58回, O70 - 6, English


• THE RELATION BETWEEN T2-FLAIR MISMATCH SIGN AND ADC VALUES REFLECTING PATHOLOGICAL MICROSTRUCTURE IN LOWER-GRADE GLIOMAS

  Yuichi Fujita, Takashi Sasayama, Hiroaki Nagashima, Kazuhiro Tanaka, Mitsuru Hashigutchi, Eiji Kohmura

  Nov. 2019, NEURO-ONCOLOGY, 21, 164 - 164, English

  Summary international conference


• MULTIPLE BIOMARKER ALGORITHM BASED ON CXCL13, IL-10, IL-2 RECEPTOR, AND beta 2-MICROGLOBULIN IN CEREBROSPINAL FLUID TO DIAGNOSE CENTRAL NERVOUS SYSTEM LYMPHOMA

  Takashi Sasayama, Kazuhiro Tanaka, Masahiro Maeyama, Satoshi Nakamizo, Hirotomo Tanaka, Masamitsu Nishihara, Takanori Hirose, Yuichi Fujita, Eiji Kohmura

  Nov. 2019, NEURO-ONCOLOGY, 21, 153 - 153, English

  Summary international conference


• 初発中枢神経悪性リンパ腫(PCNSL)に対するR-MPV療法の安全性と有用性について

  篠山 隆司, 田中 一寛, 藤田 祐一, 橋口 充, 前山 昌博, 甲村 英二

  (一社)日本癌治療学会, Oct. 2019, 日本癌治療学会学術集会抄録集, 57回, P53 - 7, English


• 小児松果体部low grade gliomanの1例

  篠山 隆司, 田中 一寛, 上原 慶一郎, 藤田 祐一, 橋口 充, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  日本脳腫瘍病理学会, May 2019, Brain Tumor Pathology, 36(Suppl.) (Suppl.), 075 - 075, Japanese


• GLUTAMINE DEPRIVATION ALTERS ONE-CARBON METABOLISM TO MAINTAIN GLIOMA CELL SURVIVAL

  Kazuhiro Tanaka, Takashi Sasayama, Takiko Uno, Masahiro Maeyama, Yuichi Fujita, Yasuhiro Irino, Eiji Kohmura

  Nov. 2018, NEURO-ONCOLOGY, 20, 34 - 34, English

  Summary international conference


• 悪性脳腫瘍に対する光線力学療法(PDT)の治療経験 PDTの照射の問題点とコツ

  篠山 隆司, 田中 一寛, 前山 昌博, 藤田 祐一, 甲村 英二

  (一社)日本癌治療学会, Oct. 2018, 日本癌治療学会学術集会抄録集, 56回, O55 - 5, English


• 膠芽腫内腫瘍関連マクロファージが膠芽腫細胞に与える影響

  篠山 隆司, 田中 一寛, 狛 雄一郎, 前山 昌博, 藤田 祐一, 中溝 聡, 西原 賢在, 廣瀬 隆則, 横崎 宏, 甲村 英二

  日本脳腫瘍病理学会, Sep. 2018, Brain Tumor Pathology, 35(Suppl.) (Suppl.), 139 - 139, Japanese


• 頭蓋内lymphomatoid granulomatosisの1例

  田中 一寛, 篠山 隆司, 藤田 祐一, 前山 昌博, 神保 直江, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  日本脳腫瘍病理学会, Sep. 2018, Brain Tumor Pathology, 35(Suppl.) (Suppl.), 176 - 176, Japanese


• 悪性脳腫瘍に対する光線力学療法(PDT)の治療経験

  篠山 隆司, 田中 一寛, 中井 友昭, 前山 昌博, 藤田 祐一, 甲村 英二

  (NPO)日本レーザー医学会, Sep. 2018, 日本レーザー医学会誌, 39(3) (3), 250 - 250, Japanese


• 頸椎損傷に伴う椎骨動脈損傷の臨床像と治療戦略

  藤田 祐一, 相原 英夫, 長嶋 宏明, 森下 暁二, 青木 謙二, 高山 博行, 原田 俊彦, 当麻 美樹, 原 淑恵, 甲村 英二

  (株)医学書院, Aug. 2018, Neurological Surgery, 46(8) (8), 663 - 671, Japanese


• 頸椎損傷に伴う椎骨動脈損傷の治療戦略

  藤田 祐一, 長嶋 宏明, 森下 暁二, 相原 英夫, 青木 謙二, 高山 博行, 原田 俊彦, 当麻 美樹, 原 淑恵, 甲村 英二

  (一社)日本脳神経外傷学会, Feb. 2018, 日本脳神経外傷学会プログラム・抄録集, 41回, 96 - 96, Japanese


• 左側頭葉に巨大シストを有する膠芽腫の1例

  藤田 祐一, 篠山 隆司, 酒井 康裕, 田中 一寛, 山本 侑毅, 山崎 隆, 坂田 純一, 前山 昌博, 廣瀬 隆則, 甲村 英二

  日本脳腫瘍病理学会, May 2017, Brain Tumor Pathology, 34(Suppl.) (Suppl.), 087 - 087, Japanese


• 長期生存膠芽腫患者の臨床像と病理学的検討

  篠山 隆司, 田中 一寛, 坂田 純一, 前山 昌博, 藤田 祐一, 山口 陽二, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  日本脳腫瘍病理学会, May 2017, Brain Tumor Pathology, 34(Suppl.) (Suppl.), 110 - 110, Japanese

• PIT1/SF1共発現を伴う先端巨大症の1例 ― 臨床病理学的検討 ―

  藤田 祐一, 神澤 真紀, 坂東 弘教, 山本 雅昭, 福岡 秀規, 魚住 洋一, 篠山 隆司

  第35回 日本間脳下垂体腫瘍学会, Feb. 2025

  Oral presentation


• 副鼻腔腫瘍として発見されたsomatotroph PitNETの一例（CPC）

  神澤真紀, 藤田祐一, 福岡秀規

  第35回 日本間脳下垂体腫瘍学会, Feb. 2025

  Oral presentation


• 聴神経腫瘍術後早期の顔面神経機能転帰を予測するためのノモグラムモデル

  藤田祐一, 魚住洋一, 藤本陽介, 長嶋宏明, 甲田将章, 田中一寛, 木村英仁, 藤田敦史, 甲村英二, 篠山隆司

  日本脳神経外科学会 第83回学術総会, Oct. 2024, Japanese

  Oral presentation


• Pituitary neuroendocrine tumor (PitNET)の術中迅速診断に迅速迅速都銀法は有用か

  神澤真紀, 今川奈央子, 塚本龍子, 藤田祐一, 福岡秀規, 伊藤智雄

  第28回日本臨床内分泌病理学会学術総会, Oct. 2024, Japanese

  Oral presentation


• A Novel Nomogram to Predict Immediate Postoperative Facial Nerve Function after Vestibular Schwannoma Resection

  Yuichi Fujita, Yoichi Uozumi, Yosuke Fujimoto, Hiroaki Nagashima, Masaaki Kohta, Kazuhiro Tanaka, Hidehito Kimura, Atsushi Fujita, Eiji Kohmura, Takashi Sasayama

  CNS 2024 Annual Meeting, Sep. 2024, English

  Poster presentation


• Koosグレード4手術において術後早期顔面神経機能に影響する形態学的要因の検討

  藤田祐一, 魚住洋一, 篠山隆司, 甲村英二

  第33回 日本聴神経腫瘍研究会, Jul. 2024, Japanese

  Oral presentation


• 聴神経腫瘍の形態学的差異が術後顔面神経機能予後に与える影響

  藤田祐一, 魚住洋一, 木村英仁, 篠山隆司, 甲村英二

  第36回 日本頭蓋底外科学会, Jul. 2024, Japanese

  Oral presentation


• 斜台部アスペルギローマに対する経鼻内視鏡手術：画像所見と術中所見の対比

  藤田祐一, 魚住洋一, 中井友昭, 蓼原瞬, 篠山隆司

  第30回日本神経内視鏡学会, Nov. 2023, Japanese

  Oral presentation


• 大型聴神経腫瘍手術における顔面神経損傷リスクを予測するための改定Koos分類

  藤田祐一, 魚住洋一, 篠山隆司, 甲村英二

  日本脳神経外科学会 第82回学術総会, Oct. 2023, Japanese

  Oral presentation


• 悪性神経膠腫に対する光線力学療法：特異的MRI画像変化と再発パターン

  藤田祐一, 長嶋宏明, 山西俊介, 田中一寛, 篠山隆司

  第34回 日本レーザー医学会西日本大会, Jul. 2023, Japanese

  Oral presentation


• 聴神経腫瘍の内耳道底伸展が術後長期顔面神経機能予後に与える影響

  藤田祐一, 魚住洋一, 篠山隆司, 甲村英二

  第35回 日本頭蓋底外科学会, Jul. 2023, Japanese

  Oral presentation


• 悪性腫瘍と鑑別を要したFDG-PET高集積を呈する頭蓋咽頭腫の1例

  藤田祐一, 魚住洋一, 山本 雅昭, 神保直江, 福岡 秀規, 篠山隆司

  第33回一般社団法人日本間脳下垂体腫瘍学会, Mar. 2023, Japanese

  Oral presentation


• 悪性神経膠腫に対する光線力学療法と特異的MRI画像変化

  藤田祐一, 長嶋宏明, 岩橋洋文, 山西俊介, 田中一寛, 篠山隆司

  第18回日本脳神経外科光線力学学会, Nov. 2022, Japanese

  Public symposium


• 下垂体腺腫と鑑別を要したintrasellar chordomaの1例

  藤田祐一, 魚住洋一, 中井友昭, 蓼原瞬, 神保直江, 中西裕子, 篠山隆司

  第29回日本神経内視鏡学会, Nov. 2022, Japanese

  Oral presentation


• 副鼻腔腫瘍として発見された下垂体腺腫の一例

  神澤真紀, 藤田祐一, 坂東弘教

  第26回日本臨床内分泌病理学会学術総会, Oct. 2022, Japanese

  [Invited]

  Oral presentation


• 聴神経腫瘍の術前MRI画像における“fundal fluid cap”の臨床的意義

  藤田祐一, 魚住洋一, 篠山隆司, 甲村英二

  日本脳神経外科学会 第81回学術総会, Sep. 2022, Japanese

  Oral presentation


• Symptom-based opioid-free treatment for persistent postoperative headache after vestibular schwannoma resection via the retrosigmoid approach

  藤田祐一, 魚住洋一, 山口陽二, 中井友昭, 篠山隆司, 甲村英二

  第34回 日本頭蓋底外科学会, Jul. 2022, Japanese

  Oral presentation


• 悪性グリオーマに対する光線力学療法後の特異的MRI画像変化と再発パターンとの関連性

  藤田祐一, 長嶋宏明, 田中一寛, 橋口充, 伊藤智雄, 篠山隆司

  第39回日本脳腫瘍学会学術集会, Dec. 2021, Japanese

  Poster presentation


• AstrocytomaにおけるT2-FLAIR mismatch signの病理放射線学的特徴

  藤田祐一, 長嶋宏明, 田中一寛, 橋口充, 廣瀬隆則, 伊藤智雄, 篠山隆司

  日本脳神経外科学会第80回学術総会, Oct. 2021, Japanese

  Oral presentation


• Diffusion-weighted imaging for monitoring the response of malignant gliomas to photodynamic therapy

  Yuichi Fujita, Takashi Sasayama, Kazuhiro Tanaka, Katsusuke Kyotani, Hiroaki Nagashima, Msaaki Kohta, Hidehito Kimura, Atsushi Fujita, Eiji Kohmura

  71st Annual Meeting of the German Society of Neurosurgery, Jun. 2020, English

  Oral presentation


• Glutamine deprivation alters one-carbon metabolism to maintain glioma cell survival

  Kazuhiro Tanaka, Takashi Sasayama, Takiko Uno, Masahiro Maeyama, Yuichi Fujita, Yasuhiro Irino, Eiji Kohmura

  24th Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO), Nov. 2019, English

  Poster presentation


• Multiple biomarker algorithm based on CXCL13, IL-10, IL-2 receptor, and β2-microglobulin in cerebrospinal fluid to diagnose central nervous system lymphoma

  Takashi Sasayama, Kazuhiro Tanaka, Masahiro Maeyama, Satoshi Nakamizo, Hirotomo Tanaka, Masamitsu Nishihara, Takanori Hirose, Yuichi Fujita, Eiji Kohmura

  24th Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO), Nov. 2019, English

  Oral presentation


• The relation between T2-FLAIR mismatch sign and apparent diffusion coefficient reflecting pathological microstructure in IDH-mutant and 1p/19q-intact gliomas

  Yuichi Fujita, Takashi Sasayama, Hiroaki Nagashima, Kazuhiro Tanaka, Mitsuru Hashiguchi, Eiji Kohmura

  24th Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO), Nov. 2019, English

  Poster presentation


• 初発中枢神経悪性リンパ腫(PCNSL)に対するR-MPV療法の安全性と有用性について

  篠山 隆司, 田中 一寛, 藤田 祐一, 橋口 充, 前山 昌博, 甲村 英二

  第57回日本癌治療学会学術集会, Oct. 2019


• Big Debate -エキスパートに学ぶ-

  藤田祐一, 谷口理章, 甲村英二

  第31回日本頭蓋底外科学会, Jul. 2019, Japanese


• 若年者に発生した鞍上部high-grade small cell gliomaの一例

  中原 正博, 篠山 隆司, 神保 直江, 荒井 篤, 田中 一寛, 橋口 充, 藤田 祐一, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  第37回日本脳腫瘍病理学会, May 2019


• 小児松果体部low grade gliomanの1例

  篠山 隆司, 田中 一寛, 上原 慶一郎, 藤田 祐一, 橋口 充, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  第37回日本脳腫瘍病理学会, May 2019


• 中枢神経悪性リンパ腫の診断バイオマーカーとしてのCXCL13の検討

  篠山 隆司, 田中 一寛, 前山 昌博, 藤田 祐一, 西原 賢在, 甲村 英二

  第36回日本脳腫瘍学会, Dec. 2018


• グルタミン飢餓状態のグリオーマ細胞における一炭素代謝の調整と新規治療標的の探索

  田中 一寛, 篠山 隆司, 宇野 滝子, 前山 昌博, 藤田 祐一, 入野 康宏, 甲村 英二

  第36回日本脳腫瘍学会, Dec. 2018


• 悪性脳腫瘍に対する光線力学療法 (PDT)の治療経験

  篠山 隆司, 田中 一寛, 中井 友昭, 前山 昌博, 藤田 祐一, 甲村 英二

  第14回日本脳神経外科光線力学学会, Nov. 2018


• Glutamine deprivation alters one-carbon metabolism to maintain glioma cell survival

  Kazuhiro Tanaka, Takashi Sasayama, Takiko Uno, Masahiro Maeyama, Yuichi Fujita, Yasuhiro Irino, Eiji Kohmura

  23rd Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO), Nov. 2018


• 経蝶形骨洞手術における低侵襲liposuction techniqueおよび “fatty candy”作成による髄液漏予防

  藤田祐一, 谷口理章, 都築貴, 中井友昭, 魚住洋一, 木村英仁, 甲村英二

  第25回一般社団法人日本神経内視鏡学会, Oct. 2018, Japanese

  Oral presentation


• H3K27M mutationおよび解剖学的局在によるmidline gliomaの予後予測

  藤田 祐一, 田中 一寛, 篠山 隆司, 前山 昌博, 伊藤 智雄, 甲村 英二

  日本脳神経外科学会第77回学術総会, Oct. 2018

  Oral presentation


• カルムスチン脳内留置用剤（ギリアデル）の治療効果と問題点

  田中 一寛, 篠山 隆司, 前山 昌博, 藤田 祐一, 伊藤 智雄, 甲村 英二

  日本脳神経外科学会第77回学術総会, Oct. 2018


• 悪性脳腫瘍に対する光線力学療法 (PDT)の治療経験－PDTの照射のコツと問題点について－

  篠山 隆司, 田中 一寛, 前山 昌博, 藤田 祐一, 甲村 英二

  第56回日本癌治療学会, Oct. 2018


• 膠芽腫における髄腔内播種の予測因子と予防手段

  篠山 隆司, 田中 一寛, 前山 昌博, 藤田 祐一, 西原 賢在, 甲村 英二

  日本脳神経外科学会第77回学術総会, Oct. 2018


• The experience of Photodynamic therapy (PDT) for malignant brain tumors

  Takashi Sasayama, Kazuhiro Tanaka, Masahiro Maeyama, Yuichi Fujita, Eiji Kohmura

  15th Meeting of the Asian Society for Neuro-Oncology (ASNO), Oct. 2018


• 頭蓋内lymphomatoid granulomatosisの1例

  田中 一寛, 篠山 隆司, 藤田 祐一, 前山 昌博, 神保 直江, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  第36回日本脳腫瘍病理学会, Sep. 2018


• 悪性脳腫瘍に対する光線力学療法 (PDT)の治療経験

  篠山 隆司, 田中 一寛, 前山 昌博, 藤田 祐一, 甲村 英二

  第23回日本脳腫瘍の外科学会, Sep. 2018


• 膠芽腫内腫瘍関連マクロファージが膠芽腫細胞に与える影響

  篠山 隆司, 田中 一寛, 狛 雄一朗, 前山 昌博, 藤田 祐一, 中溝 聡, 西原 賢在, 廣瀬 隆則, 横崎 宏, 甲村 英二

  第36回日本脳腫瘍病理学会, Sep. 2018


• 膠芽腫における播種および予後因子 stanniocalcin-1(STC1)の解析

  篠山 隆司, 坂田 純一, 田中 一寛, 前山 昌博, 藤田 祐一, 甲村 英二

  第19回日本分子脳神経外科学会, Aug. 2018


• 頚椎脱臼整復後の 脳梗塞予防を目的とした治療戦略

  藤田祐一, 長嶋 宏明, 森下 暁二, 相原 英夫, 青木 謙二, 高山 博行, 原田 俊彦, 当麻 美樹, 原 淑恵, 甲村 英二

  第43回日本脳卒中学会学術集会（STROKE 2018）, Mar. 2018, Japanese

  Oral presentation


• 救命救急センターにおける外傷性てんかん

  長嶋 宏明, 藤田 祐一, 森下 暁二, 相原 英夫, 当麻 美樹

  第41回日本神経外傷学会, Feb. 2018


• 頸椎損傷に伴う椎骨動脈損傷の治療戦略

  藤田祐一, 長嶋 宏明, 森下 暁二, 相原 英夫, 青木 謙二, 高山 博行, 原田 俊彦, 当麻 美樹, 原 淑恵, 甲村 英二

  第41回日本神経外傷学会, Feb. 2018, Japanese

  Oral presentation


• 頸椎損傷に伴う椎骨動脈損傷の臨床像および治療戦略

  藤田祐一, 長嶋 宏明, 森下 暁二, 相原 英夫, 青木 謙二, 高山 博行, 原田 俊彦, 当麻 美樹, 原 淑恵, 甲村 英二

  日本脳神経外科学会第76回学術総会, Oct. 2017, Japanese


• Glioblastoma with PNET-like componentsの初期病理像を確認できた1例

  田中 一寛, 篠山 隆司, 川上 史, 大谷 恭子, 酒井 康裕, 前山 昌博, 藤田 祐一, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  第35回日本脳腫瘍病理学会, May 2017


• 左側頭葉に巨大シストを有する膠芽腫の1例（Clinicopathological Conference）

  藤田 祐一, 篠山 隆司, 酒井 康裕, 田中 一寛, 山本 侑毅, 山崎 隆, 坂田 純一, 前山 昌博, 廣瀬 隆則, 甲村 英二

  第35回日本脳腫瘍病理学会, May 2017, Japanese

  Oral presentation


• 長期生存膠芽腫患者の臨床像と病理学的検討

  篠山 隆司, 田中 一寛, 坂田 純一, 前山 昌博, 藤田 祐一, 山口 陽二, 伊藤 智雄, 廣瀬 隆則, 甲村 英二

  第35回日本脳腫瘍病理学会, May 2017


• 急性期CASが奏功した症候性両側頚部内頚動脈解離

  藤田 祐一, 甲田 将章, 藤田 敦史

  第29回北六甲脳神経外科カンファレンス, Feb. 2017, Japanese

  Oral presentation


• 蝶形骨洞内に再発した頭蓋咽頭腫の3例

  藤田 祐一, 谷口 理章, 中井 友昭, 木村 英仁, 甲村 英二

  第72回 日本脳神経外科学会近畿支部学術集会, Sep. 2016, Japanese

  Oral presentation


• 80歳以上のくも膜下出血症例の臨床像と治療成績

  藤田 祐一, 阪上 義雄, 中溝 聡

  日本脳神経外科学会第74回学術総会, Oct. 2015, Japanese

  Oral presentation


• 下垂体卒中を来したpituitary silent corticotroph adenomaの1例

  藤田 祐一, 近藤 威, 鈴木 寿彦, 高石 吉将, 千葉 義幸

  第69回日本脳神経外科学会近畿支部学術集会, Apr. 2015, Japanese

  Oral presentation


• 病診連携が奏功した典型的・非典型的症状を呈した脳卒中

  藤田 祐一, 千葉 義幸, 髙石 吉將, 近藤 威, 鈴木 壽彦

  須磨区医師会 第30回学術集談会, Mar. 2015, Japanese

  [Invited]

  Oral presentation


• Castleman病を呈する稀少な小児第3脳室内choldoid meningiomaの１例

  藤田 祐一, 阿久津 宣行, 山元 一樹, 河村 淳史, 長嶋 達也

  第68回日本脳神経外科学会近畿支部学術集会, Sep. 2014, Japanese

  Oral presentation


• 非もやもや病頭蓋内血管狭窄による小児脳梗塞の4例

  藤田 祐一, 阿久津 宣行, 山元 一樹, 河村 淳史, 長嶋 達也

  日本脳神経外科学会第73回学術総会, Sep. 2014, Japanese

  Poster presentation


• 前駆症状のない感染性心内膜炎による小児脳梗塞の1例

  藤田 祐一, 阿久津 宣行, 河村 淳史, 山元 一樹, 長嶋 達也

  第44回兵庫県脳神経外科医懇話会, Jul. 2014, Japanese

  Oral presentation


• 初期治療10年後に再発を来したcentral neurocytomaの1例

  田中 宏知, 山下 晴央, 沖野 毅, 原 淑恵, 林 成人, 山本 祐輔, 藤田 祐一

  第32回日本脳腫瘍病理学会, May 2014


• 未破裂脳動脈瘤を合併した症候性内頚動脈狭窄症の2例

  藤田 祐一, 原 淑恵, 山本 祐輔, 田中 宏知, 林 成人, 山下 晴央

  第67回日本脳神経外科学会近畿支部学術集会, Apr. 2014, Japanese

  Oral presentation


• 初回減圧開頭術に連続して対側手術を要した重症頭部外傷 7症例

  藤田 祐一, 林 成人, 田中 宏知, 山本 祐輔, 原 淑恵, 山下 晴央, 甲村 英二

  日本脳神経外科学会第72回学術総会, Oct. 2013, Japanese

  Oral presentation


• Initial contrecoup craniectomy and subsequent coup surgery for patients with severe traumatic brain injury

  Yuichi Fujita, Shigeto Hayashi, Hirotomo Tanaka, Yusuke Yamamoto, Yoshie Hara, Haruo Yamashita, Eiji Kohmura

  The Fourth International MASSIN Congress, Sep. 2013, English

  Oral presentation


• ICP測定下に治療を施行したが救命困難であった重症頭部外傷8症例

  藤田 祐一, 林 成人, 田中 宏知, 山本 祐輔, 原 淑恵, 山下 晴央

  第43回兵庫県脳神経外科医懇話会, Jul. 2013, Japanese

  Oral presentation


• 初回開頭術に連続して対側の手術を要した重症頭部外傷の4症例

  藤田 祐一, 林 成人, 田中 宏知, 井上 悟志, 原 淑恵, 山下 晴央

  第65回日本脳神経外科学会近畿支部学術集会, Apr. 2013, Japanese

  Oral presentation

• Congress of Neurological Surgeons (International membership)


• 日本内分泌学会


• 日本脳卒中学会


• 日本聴神経腫瘍研究会


• 日本間脳下垂体腫瘍学会


• 日本神経内視鏡学会


• 日本頭蓋底外科学会


• 日本脳神経外科コングレス


• 日本脳神経外科学会

• Visiting fellow. Department of Neurosurgery, University of Tubingen, Germany

  Yuichi Fujita

  Oct. 2016

• Microbiota of ketogenic diet in glioblastoma patients and enhancement effect of synbiotics

  篠山 隆司, 長嶋 宏明, 藤田 祐一, 田中 一寛

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2024 - Mar. 2027


• Developments of surgical systems for skull base surgery and surgical education

  魚住 洋一, 篠山 隆司, 藤田 祐一, 中井 友昭, 木村 英仁

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2022 - 31 Mar. 2025


• Development of new treatments for medulloblastoma targeting macrophage

  西原 賢在, 長嶋 宏明, 篠山 隆司, 藤田 祐一, 田中 一寛

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2022 - 31 Mar. 2025