Research activity information

• Roles of afadin in functional differentiations of hippocampal mossy fiber synapse

  Xiaoqi Geng, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata, Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai, Masahiro Mori

  Aug. 2017, GENES TO CELLS, 22(8) (8), 715 - 722, English

  [Refereed]

  Scientific journal


• Roles of afadin in functional differentiations of hippocampal mossy fiber synapse

  Xiaoqi Geng, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata, Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai, Masahiro Mori

  Aug. 2017, GENES TO CELLS, 22(8) (8), 715 - 722, English

  [Refereed]

  Scientific journal


• Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus

  Noriomi Eguchi, Akitoyo Hishimoto, Ichiro Sora, Masahiro Mori

  Mar. 2016, NEUROSCIENCE LETTERS, 616, 170 - 176, English

  [Refereed]

  Scientific journal


• Activity-dependent alteration of the morphology of a hippocampal giant synapse

  Tomohiko Maruo, Kenji Mandai, Yoshimi Takai, Masahiro Mori

  Mar. 2016, MOLECULAR AND CELLULAR NEUROSCIENCE, 71, 25 - 33, English

  [Refereed]

  Scientific journal


• Regulatory role of the cell adhesion molecule nectin-1 in GABAergic inhibitory synaptic transmission in the CA3 region of mouse hippocampus

  Xiaoqi Geng, Kenji Mandai, Tomohiko Maruo, Shujie Wang, Takeshi Fujiwara, Akira Mizoguchi, Yoshimi Takai, Masahiro Mori

  Jan. 2016, GENES TO CELLS, 21(1) (1), 88 - 98, English

  [Refereed]

  Scientific journal


• Nectin-1 spots regulate the branching of olfactory mitral cell dendrites

  Takeshi Fujiwara, Takahito Inoue, Tomohiko Maruo, Yoshiyuki Rikitake, Nao Ieki, Kenji Mandai, Kazushi Kimura, Tetsuro Kayahara, Shujie Wang, Yu Itoh, Kousyoku Sai, Masahiro Mori, Kensaku Mori, Yoshimi Takai, Akira Mizoguchi

  Sep. 2015, MOLECULAR AND CELLULAR NEUROSCIENCE, 68, 143 - 150, English

  [Refereed]

  Scientific journal


• Monosynaptic excitatory transmission from the hippocampal CA1 region to the subiculum

  Xiaoqi Geng, Masahiro Mori

  Sep. 2015, NEUROSCIENCE LETTERS, 604, 42 - 46, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Nectin-1 spots as a novel adhesion apparatus that tethers mitral cell lateral dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb

  Takahito Inoue, Takeshi Fujiwara, Yoshiyuki Rikitake, Tomohiko Maruo, Kenji Mandai, Kazushi Kimura, Tetsuro Kayahara, Shujie Wang, Yu Itoh, Kousyoku Sai, Masahiro Mori, Kensaku Mori, Akira Mizoguchi, Yoshimi Takai

  Aug. 2015, JOURNAL OF COMPARATIVE NEUROLOGY, 523(12) (12), 1824 - 1839, English

  [Refereed]

  Scientific journal


• Afadin Regulates Puncta Adherentia Junction Formation and Presynaptic Differentiation in Hippocampal Neurons

  Daisaku Toyoshima, Kenji Mandai, Tomohiko Maruo, Irwan Supriyanto, Hideru Togashi, Takahito Inoue, Masahiro Mori, Yoshimi Takai

  Feb. 2014, PLOS ONE, 9(2) (2), e89763, English

  [Refereed]

  Scientific journal


• Roles of nectins and nectin-like molecules in the nervous system

  Mori M, Rikitake Y, Mandai Kenji, Takai Yoshimi

  2014, Adv Neurobiol, 8, 91 - 116, English

  [Refereed]

  Scientific journal


• Immunoglobulin superfamily receptors and adherens junctions.

  Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori, Yoshimi Takai

  The immunogroblin (Ig) superfamily proteins characterized by the presence of Ig-like domains are involved in various cellular functions. The properties of the Ig-like domains to form rod-like structures and to bind specifically to other proteins make them ideal for cell surface receptors and cell adhesion molecules (CAMs). Ig-CAMs, nectins in mammals and Echinoid in Drosophila, are crucial components of cadherin-based adherens junctions in the epithelium. Nectins form cell-cell adhesion by their trans-interactions and recruit cadherins to the nectin-initiated cell-cell adhesion site to establish adherens junctions. Thereafter junction adhesion molecules, occludin, and claudins, are recruited to the apical side of adherens junctions to establish tight junctions. The recruitment of these molecules by nectins is mediated both by the direct and indirect interactions of afadin with many proteins, such as catenins, and zonula occludens proteins, and by the nectin-induced reorganization of the actin cytoskeleton. Nectins contribute to the formation of both homotypic and heterotypic types of cell-cell junctions, such as synapses in the brain, contacts between pigment and non-pigment cell layers of the ciliary epithelium in the eye, Sertoli cell-spermatid junctions in the testis, and sensory cells and supporting cells in the sensory organs. In addition, cis- and trans-interactions of nectins with various cell surface proteins, such as integrins, growth factor receptors, and nectin-like molecules (Necls) play important roles in the regulation of many cellular functions, such as cell polarization, movement, proliferation, differentiation, survival, and cell sorting. Furthermore, the Ig-CAMs are implicated in many human diseases including viral infections, ectodermal dysplasia, cancers, and Alzheimer's disease.

  2012, Sub-cellular biochemistry, 60, 137 - 70, English, International magazine

  Scientific journal


• Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity

  Alanna J. Watt, Hermann Cuntz, Masahiro Mori, Zoltan Nusser, P. Jesper Sjostrom, Michael Hausser

  Apr. 2009, NATURE NEUROSCIENCE, 12(4) (4), 463 - 473, English

  [Refereed]

  Scientific journal


• Recruitment of an inhibitory hippocampal network after bursting in a single granule cell

  Masahiro Mori, Beat H. Gahwiler, Urs Gerber

  May 2007, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104(18) (18), 7640 - 7645, English

  [Refereed]

  Scientific journal


• A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit

  M Mori, MH Abegg, BH Gahwiler, U Gerber

  Sep. 2004, NATURE, 431(7007) (7007), 453 - 456, English

  [Refereed]

  Scientific journal


• Slow feedback inhibition in the CA3 area of the rat hippocampus by synergistic synaptic activation of rnGluR1 and mGluR5

  M Mori, U Gerber

  Nov. 2002, JOURNAL OF PHYSIOLOGY-LONDON, 544(3) (3), 793 - 799, English

  [Refereed]

  Scientific journal


• Slow feedback inhibition in the CA3 area of the rat hippocampus by synergistic synaptic activation of rnGluR1 and mGluR5

  M Mori, U Gerber

  Nov. 2002, JOURNAL OF PHYSIOLOGY-LONDON, 544(3) (3), 793 - 799, English

  [Refereed]

  Scientific journal


• beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro

  M Mori, BH Gahwiler, U Gerber

  Feb. 2002, JOURNAL OF PHYSIOLOGY-LONDON, 539(1) (1), 191 - 200, English

  [Refereed]

  Scientific journal


• beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro

  M Mori, BH Gahwiler, U Gerber

  Feb. 2002, JOURNAL OF PHYSIOLOGY-LONDON, 539(1) (1), 191 - 200, English

  [Refereed]

  Scientific journal


• Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures

  M Mori, C Heuss, BH Gahwiler, U Gerber

  Aug. 2001, JOURNAL OF PHYSIOLOGY-LONDON, 535(1) (1), 115 - 123, English

  [Refereed]

  Scientific journal


• Apamin-sensitive conductance mediates the K+ current response during chemical ischemia in CA3 pyramidal cells

  M Tanabe, M Mori, BH Gahwiler, U Gerber

  Dec. 1999, JOURNAL OF NEUROPHYSIOLOGY, 82(6) (6), 2876 - 2882, English

  [Refereed]

  Scientific journal


• Glutamate-induced currents in acutely dissociated guinea pig locus coeruleus neurons.

  森 正弘

  1999, Kobe Journal of Medical Science, English

  [Refereed]

  Scientific journal


• Diverse signal transduction pathways mediated by endogenous P-2 receptors in cultured rat cerebral cortical neurons

  T Nishizaki, M Mori

  May 1998, JOURNAL OF NEUROPHYSIOLOGY, 79(5) (5), 2513 - 2521, English

  [Refereed]

  Scientific journal


• ATP produces potassium currents via P-3 purinoceptor in the follicle cell layer of Xenopus oocytes

  T Matsuoka, T Nishizaki, T Nomura, M Mori, Y Okada

  May 1998, NEUROSCIENCE LETTERS, 248(2) (2), 130 - 132, English

  [Refereed]

  Scientific journal


• Calcium release from intracellular stores evoked by extracellular ATP in a Xenopus renal epithelial cell line

  M Mori, H Hosomi, T Nishizaki, K Kawahara, Y Okada

  Jul. 1997, JOURNAL OF PHYSIOLOGY-LONDON, 502(2) (2), 365 - 373, English

  [Refereed]

  Scientific journal


• GABA-activated conductance in cultured rat inferior colliculus neurons

  H Hosomi, M Mori, M Amatsu, Y Okada

  Feb. 1997, JOURNAL OF NEUROPHYSIOLOGY, 77(2) (2), 994 - 1002, English

  [Refereed]

  Scientific journal


• Non-selective cation conductance in a Xenopus renal epithelial line.

  森 正弘

  1997, Kobe Journal of Medical Science, English

  [Refereed]

  Scientific journal


• Adenosine activates the K+ channel and enhances cytosolic Ca2+ release via a P-2Y purinoceptor in hippocampal neurons

  Y Ikeuchi, T Nishizaki, M Mori, Y Okada

  May 1996, EUROPEAN JOURNAL OF PHARMACOLOGY, 304(1-3) (1-3), 191 - 199, English

  [Refereed]

  Scientific journal


• ATP-activated cation conductance in a Xenopus renal epithelial cell line

  M Mori, T Nishizaki, K Kawahara, Y Okada

  Mar. 1996, JOURNAL OF PHYSIOLOGY-LONDON, 491(2) (2), 281 - 290, English

  [Refereed]

  Scientific journal


• Regulation of the potassium current and cytosolic Ca2+ release induced by 2-methylthio ATP in hippocampal neurons

  Y Ikeuchi, T Nishizaki, M Mori, Y Okada

  Jan. 1996, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 218(2) (2), 428 - 433, English

  [Refereed]

  Scientific journal


• ADENOSINE ACTIVATES THE POTASSIUM CHANNEL VIA A P-2 PURINOCEPTOR BUT NOT VIA AN ADENOSINE RECEPTOR IN CULTURED RAT SUPERIOR COLLICULUS NEURONS

  Y IKEUCHI, T NISHIZAKI, M MORI, Y OKADA

  Oct. 1995, NEUROSCIENCE LETTERS, 198(3) (3), 205 - 208, English

  [Refereed]

  Scientific journal


• EXCITATORY EFFECT OF ADENOSINE ON NEUROTRANSMISSION IS DUE TO INCREASE OF TRANSMITTER RELEASE IN THE HIPPOCAMPAL SLICES

  Y OKADA, T SAKURAI, M MORI

  Aug. 1992, NEUROSCIENCE LETTERS, 142(2) (2), 233 - 236, English

  [Refereed]

  Scientific journal


• PROTECTIVE EFFECT OF ADENOSINE ON THE ANOXIC DAMAGE OF HIPPOCAMPAL SLICE

  M MORI, T NISHIZAKI, Y OKADA

  Jan. 1992, NEUROSCIENCE, 46(2) (2), 301 - 307, English

  [Refereed]

  Scientific journal


• EXCITATORY AND INHIBITORY EFFECTS OF ADENOSINE ON THE NEUROTRANSMISSION IN THE HIPPOCAMPAL SLICES OF GUINEA-PIG

  S NISHIMURA, M MOHRI, Y OKADA, M MORI

  Aug. 1990, BRAIN RESEARCH, 525(1) (1), 165 - 169, English

  [Refereed]

  Scientific journal

• Nectins and Nectin-Like Molecules in Development and Disease

  Kenji Mandai, Yoshiyuki Rikitake, Masahiro Mori, Yoshimi Takai

  2015, CELLULAR ADHESION IN DEVELOPMENT AND DISEASE, 112, 197 - 231, English

  [Refereed][Invited]

  Introduction scientific journal

• Roles of nectins and nectin-like molecules in the nervous system.

  MORI MASAHIRO

  Others, Adv Neurobiol, 2014, English

  Scholarly book


• Immunoglobulin superfamily receptors and adherens junctions.

  森 正弘

  Others, Subcell Biochem, 2012, English

  Scholarly book

• 海馬におけるグリシン受容体の役割

  池田省一郎, 木村嘉成, 森 正弘

  第99回日本生理学会大会（仙台）, Mar. 2022, Japanese

  Poster presentation


• 脊髄運動ニューロンにおける電気シナプスの役割

  木村嘉成, 池田省一郎, 森 正弘

  第99回日本生理学会大会（仙台）, Mar. 2022, Japanese

  Poster presentation


• 海馬におけるグリシン抑制電流

  佐藤駿介, 江口典臣, 森 正弘

  第117回日本精神神経学会学術総会（京都）, Sep. 2021, Japanese

  Poster presentation


• Involvement of afadin in molecular and functional presynaptic differentiation of hippocampal neurons

  丸尾 知彦, Mandai Kenji, 宮田 宗明, 榊原 正太郎, 王 淑杰, 崔 煌植, 伊藤 優, 垣内 愛加, 藤原 武志, 耿 瀟奇, イルワン スプリヤント, 溝口 明, Mori Masahiro, Takai Yoshimi

  The 40th Annual Meeting of the Japan Neuroscience Society, Jul. 2017, English, The Japan Neuroscience Sociewty, 幕張, Makuhari, Domestic conference

  Poster presentation


• Glycine-activated outward currents in neurons of the hippocampus

  佐藤駿介, 江口典臣, Mori Masahiro

  The 46th Annual Meeting of the Society for Neuroscience, Nov. 2016, English, The Society for Neuroscience, San Diego, USA, Glycine receptor-channels permeate anions such as chloride, and hyperpolarize adult neurons. Their molecular identities of glycine receptors such as amino acid sequences and subunit compositions are well clarified. Glycine receptors are widely expressed t, International conference

  Poster presentation


• Different roles of two splicing variants of afadin in mossy fiber synapse differentiation

  Maruo Tomohiko, Mandai Kenji, 榊原 正太郎, 伊藤 優, 藤原 武志, 王 淑杰, 崔 煌植, 垣内 愛加, 耿 瀟奇, Mori Masahiro, 溝口 明, Takai Yoshimi, Miyata Muneaki

  第39回日本神経科学大会, Jul. 2016, Japanese, 日本神経科学学会, 横浜, Domestic conference

  Poster presentation


• AdAMS: Activith-dependent alteration of morphology of a hippocampal mossy fiber bouton.

  Maruo Tomohiko, Mandai Kenji, Takai Yoshimi, Mori Masahiro

  第38回日本神経科学大会, Jul. 2015, English, 日本神経科学会, 神戸, Domestic conference

  Poster presentation


• Afadin Plays an Important Role in Formation of Puncta Adherentia Junction and Differentiation of Presynapses in Hippocampal Neurons.

  Toyoshima Daisaku, Mandai Kenji, Maruo Tomohiko, Irwan Supriyanto, Togashi Hideru, Takahito Inoue, Mori Masahiro, Takai Yoshimi

  American society of neuroscience; annual meeting 2014, Nov. 2014, English, SfN, Washington DC, USA, International conference

  Poster presentation


• Roles of electrical coupling between spinal motor neurons

  Mori Masahiro, 堀 雄一

  Neuro2010, Sep. 2010, English, 日本神経科学学会、日本神経化学会、日本神経回路学会, 神戸, Domestic conference

  Poster presentation


• Electrical synapses between spinal motor neurons

  Mori Masahiro, 堀 雄一

  第87回日本生理学会大会, May 2010, English, 日本生理学会, 盛岡, Domestic conference

  Poster presentation

• 脳海馬における記憶・学習神経回路の解析:単一苔状線維シナプス可塑性のメカニズム

  森正弘

  文部科学省, 科学研究費補助金(基盤研究(C)), 2009 - 2011, Principal investigator

  記憶の貯蔵と消去の鍵となる部位である脳海馬、CA3野錐体細胞の苔状線維シナプスにおいて、学習に関連した細胞レベルのモデルと考えられている長期増強現象(LTP)の特性を明らかにすることは、記憶のメカニズムを理解する上で大変重要である。本年度は、苔状線維シナプスでのLTPを誘発するために必要な条件を明らかにすることを目標として、研究を行った。実験標本としては、ローラーチューブ法に基づく培養海馬切片を用いた。本培養脳切片標本では海馬歯状回やCA3野の構造がよく保たれ、また、急性脳切片標本に伴う、多くの神経軸索路が切断されているという問題から無縁である。シナプス後細胞となるCA3野錐体細胞からパッチクランプ全細胞記録を行い、次に歯状回顆粒細胞層を高濃度カリウム内液で満たしたパッチ電極でシステマチックに走査することにより、連絡顆粒細胞を同定、パッチクランプ記録し、連絡した顆粒細胞-CA3野錐体細胞対の記録を行った。単一顆粒細胞

  Competitive research funding


• 中枢神経系の神経伝達に対するアデノシン、ATPの生理作用とその分子機構の解明

  森正弘

  文部科学省, 科学研究費補助金(奨励研究(A)), 1998 - 1999, Principal investigator

  中枢神経系の神経伝達に対するアデノシンおよびアデノシン三燐酸(以下ATPと略)の生理作用およびその分子機構を解明するために、平成10年度は、既に我々が確立している初代培養神経細胞等の培養細胞において、アデノシンおよびATPを細胞より投与し、パッチクランプ法にて記録した全細胞電流に対する効果を検討し、まず、細胞膜の興奮性の調節に関与するのか否かを明らかにした後、更に、二次メッセンジャ-に対する特異的阻害剤、保進剤を用いて、その調節作用において、アデノシンおよびATP受容体に関与する細胞内情報伝達機構を明らかにすることを試みた。その結果、培養神経細胞に発現している、GTP結合蛋白質と共役したP2Y受容体を介した、ATPとアデノシンによるカリウムチャネルの活性化作用、細胞内カルシウム濃度増加作用、さらに、その細胞内情報伝達に関わるGTP結合蛋白質、イノシト-ル燐脂質代謝、蛋白燐酸化酵素Cの調節機序を明らかにし、ATPおよびアデノシンに

  Competitive research funding