Research activity information

• Jun. 2019 Japanese Orthapaedic Association, JOA-AOA Travelling Fellowship, Alignment and soft tissue balance in total knee arthroplasty

  MATSUMOTO Tomoyuki


• Oct. 2014 Knee Society, John N. Insall Travelling Fellowship, Soft tissue balance in total knee arthroplasty

  MATSUMOTO Tomoyuki


• May 2012 日本整形外科学会, 平成23年度日本整形外科学会奨励賞, Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.

  Matsumoto Tomoyuki


• Oct. 2011 神戸大学医学部, 平成22年度神戸大学医学部優秀学術論文賞, Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.

  Matsumoto Tomoyuki


• Mar. 2009 日本再生医療学会, 日本再生医療学会Young Investigator's Award, Lnk Dependent Axis of SCF-cKit Signal for Osteogenesis in Bone Fracture Healing.

  Matsumoto Tomoyuki


• Aug. 2008 SICOT, SICOT/SIROT Award, Therapeutic Potential of Vasculogenesis and Osteogenesis Promoted by Peripheral Blood CD34-positive Cells for Functional Bone Healing.

  Matsumoto Tomoyuki


• Aug. 2008 ASBMR, ASBMR Harold M. Frost Young Investigator Award, Blocking VEGF as a potential approach to improve cartilage healing after OA

  Matsumoto Tomoyuki

• SPRR1A is a potential therapeutic target for osteosarcoma: in vitro and in vivo evaluations using generated artificial osteosarcoma cancer stem cell‑like cells.

  Tomohiro Miyamoto, Naomasa Fukase, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Ryoko Sawada, Yuta Nakamatsu, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Toshiyuki Takemori, Shunsuke Yahiro, Ryosuke Kuroda, Toshihiro Akisue

  Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.

  Feb. 2025, Oncology reports, 53(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Leveraging AI models for lesion detection in osteonecrosis of the femoral head and T1‐weighted MRI generation from radiographs

  Issei Shinohara, Atsuyuki Inui, Katherine Hwang, Masatoshi Murayama, Yosuke Susuki, Tomohiro Uno, Qi Gao, Mayu Morita, Simon Kwoon‐Ho Chow, Masanori Tsubosaka, Yutaka Mifune, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman

  Abstract This study emphasizes the importance of early detection of osteonecrosis of the femoral head (ONFH) in young patients on long‐term glucocorticoid therapy, including those with acute lymphoblastic leukemia, lupus, and other diagnoses. While X‐ray and magnetic resonance imaging (MRI) are standard imaging methods for staging ONFH, MRI can be costly and time‐consuming. The research focuses on utilizing artificial intelligence (AI) to enhance the evaluation of radiographic images for ONFH detection. The study involved analyzing X‐ray and MRI from 102 control hips and 104 ONFH‐affected hips at Association Research Circulation Osseous (ARCO) Stage II and IIIa. We employed transfer learning with the YOLOv8 model for object detection, using 80% of the data for training and 20% for validation, then assessed detection accuracy through mean average precision (mAP) and a precision‐recall curve. Additionally, AI generated synthetic MRI (sMRI) from X‐ray images using a Generative Adversarial Network (GAN) and evaluated their similarity to original MRI. Results showed that the mAP for ONFH detection was 0.923 for the YOLOv8n model and 0.951 for YOLOv8x. The GAN‐generated sMRI exhibited lower image quality compared with originals but maintained potential for lesion assessment. Intrarater reliability among evaluators was high. The findings indicate that AI techniques, particularly YOLOv8 for object detection and GAN for image generation, can effectively assist in ONFH screening, despite some limitations in the generated MRI quality.

  Wiley, Nov. 2024, Journal of Orthopaedic Research

  Scientific journal


• Human uncultured adipose-derived stromal vascular fraction shows therapeutic potential against osteoarthritis in immunodeficient rats via direct effects of transplanted M2 macrophages.

  Yuma Onoi, Tomoyuki Matsumoto, Kensuke Anjiki, Shinya Hayashi, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kemmei Ikuta, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takuma Maeda, Akira Saitoh, Takafumi Hiranaka, Satoshi Sobajima, Hideki Iwaguro, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: The uncultured adipose-derived stromal vascular fraction (SVF), consisting of adipose-derived stromal cells (ADSCs), M2 macrophages (M2Φ) and others, has shown therapeutic potential against osteoarthritis (OA), however, the mechanisms underlying its therapeutic effects remain unclear. Therefore, this study investigated the effects of the SVF on OA in a human-immunodeficient rat xenotransplantation model. METHODS: OA model was induced in the knees of female immunodeficient rats by destabilization of the medial meniscus. Immediately after the surgery, human SVF (1 × 105), ADSCs (1 × 104), or phosphate buffered saline as a control group were transplanted into the knees. At 4 and 8 weeks postoperatively, OA progression and synovitis were analyzed by macroscopic and histological analyses, and the expression of collagen II, SOX9, MMP-13, ADAMTS-5, F4/80, CD86 (M1), CD163 (M2), and human nuclear antigen (hNA) were evaluated immunohistochemically. In vitro, flow cytometry was performed to collect CD163-positive cells as M2Φ from the SVF. Chondrocyte pellets (1 × 105) were co-cultured with SVF (1 × 105), M2Φ (1 × 104), and ADSCs (1 × 104) or alone as a control group, and the pellet size was compared. TGF-β, IL-10 and MMP-13 concentrations in the medium were evaluated using enzyme-linked immunosorbent assay. RESULTS: In comparison with the control and ADSC groups, the SVF group showed significantly slower OA progression and less synovitis with higher expression of collagen II and SOX9, lower expression of MMP-13 and ADAMTS-5, and lower F4/80 and M1/M2 ratio in the synovium. Only the SVF group showed partial expression of hNA-, CD163-, and F4/80-positive cells in the rat synovium. In vitro, the SVF, M2Φ, ADSC and control groups, in that order, showed larger pellet sizes, higher TGF-β and IL-10, and lower MMP-13 concentrations. CONCLUSIONS: The M2Φ in the transplanted SVF directly affected recipient tissue, enhancing the secretion of growth factors and chondrocyte-protecting cytokines, and partially improving chondrocytes and joint homeostasis. These findings indicate that the SVF is as an effective option for regenerative therapy for OA, with mechanisms different from those of ADSCs.

  Sep. 2024, Stem cell research & therapy, 15(1) (1), 325 - 325, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The medullary cavity morphology of the proximal femur influences the fixation pattern of the rectangular tapered short stem in total hip arthroplasty.

  Yuma Onoi, Shinya Hayashi, Takaaki Fujishiro, Yuichi Kuroda, Naoki Nakano, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: This study aimed to evaluate differences in the pattern of fixation with a rectangular tapered short stem (Fitmore stem) due to proximal femoral medullary cavity morphology based on periprosthetic bone mineral density (BMD) and radiological findings. MATERIALS AND METHODS: We analyzed 105 consecutive patients (Dorr type A, 18; Dorr type B, 66; Dorr type C, 21) who underwent total hip arthroplasty using a Fitmore stem. Periprosthetic BMD was measured using dual-energy X-ray absorptiometry from 1 to 24 months postoperatively and radiological analysis was performed. Clinical outcomes were evaluated using the Harris hip score (HHS) and the University of California Los Angeles (UCLA) activity score preoperatively and 24 months postoperatively. RESULTS: At 24 months postoperatively, Dorr type C had significantly decreased BMD changes in Gruen zones 2, 6, and 7 compared to Dorr types A and B, and conversely, significantly increased BMD changes in zone 4 (p < 0.05). Dorr type C had significantly greater subsidence than the other types (p < 0.01) and significantly higher cortical hypertrophy in zone 3 (p < 0.01). Stress shielding was not significantly different between Dorr types. The preoperative and postoperative HHS and UCLA activity scores showed no significant differences between the Dorr types. CONCLUSIONS: In Dorr type C, BMD significantly decreased in the proximal femur with a rectangular tapered short stem, suggesting that the stem was fixed at the distal part. Careful observation of this prosthesis over time is needed in patients with Dorr type C.

  Aug. 2024, Archives of orthopaedic and trauma surgery, 144(8) (8), 3857 - 3864, English, International magazine

  Scientific journal


• Morphological analysis of the distal femur as a surgical reference in biplane distal femoral osteotomy.

  Shohei Sano, Takehiko Matsushita, Naosuke Nagata, Takeo Tokura, Koji Nukuto, Yuta Nakanishi, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  Distal femoral osteotomy (DFO) is performed alone or with high tibial osteotomy (HTO) for patients with osteoarthritis and distal femur deformities. DFO is technically demanding, particularly when creating an anterior flange. Herein, we examined the morphological characteristics of the distal femur based on the cortical shape as a surgical reference for biplanar DFO. Computed tomography images of 50 valgus and 50 varus knees of patients who underwent biplanar DFO or total knee arthroplasty were analyzed. Axial slices at the initial level of the transverse osteotomy in the DFO and slices 10 mm proximal and 10 mm distal to that level were selected. The medial and lateral cortical angles and heights (MCLA, LCLA, MCH, and LCH) were measured on axial slices. Statistical comparisons were performed between the medial and lateral cortices and valgus and varus knees. MCLA and MCH were significantly smaller and lower, respectively, than LCLA and LCH (P < 0.01). The MCLA and MCH of varus knees were significantly smaller and lower, respectively, than those of valgus knees (P < 0.01). Surgeons should carefully observe morphological differences in the distal femur cortex, distinguishing between medial and lateral knees and varus and valgus knees during the creation of the anterior flange in the DFO.

  May 2024, Scientific reports, 14(1) (1), 12130 - 12130, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The assessment of canal flare index and proximal femoral bone density can improve stem selection for peri-prosthetic bone maintenance after total hip arthroplasty.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Shotaro Tachibana, Ryosuke Kuroda

  INTRODUCTION: Bone maintenance after total hip arthroplasty (THA) is important for implant success. This study aimed to investigate the relationship between patient characteristics and periprosthetic bone maintenance after THA for better implant selection. MATERIALS AND METHODS: This retrospective cohort study enrolled 112 consecutive patients who underwent THA using full hydroxyapatite (HA) compaction with short (n = 55) or short-tapered wedge (n = 61) stems. Periprosthetic bone mineral density (BMD) was compared between the two groups after propensity score matching, and the relationship between periprosthetic BMD changes and patient background was analyzed. RESULTS: Both groups showed similar periprosthetic BMD changes after adjusting for patient background using propensity score matching. Canal flare index > 3.7 in patients that underwent THA using tapered-wedge stem (odds ratio (OR), 3.2; 95% confidence interval (CI), 1.3-7.9, p = 0.013) and baseline zone 1 BMD > 0.65 in patients that received with short HA compaction stems (OR, 430.0; 95% CI 1.3-1420, p = 0.040) were associated with proximal periprosthetic bone maintenance after THA. CONCLUSION: Considering their predictive value, canal flare index and zone 1 BMD assessment might be useful strategies for implant selection during THA.

  May 2024, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Influence of Distal Reference Point of the Tibial Mechanical Axis on the Ankle and Hindlimb Alignment Change after Total Knee Arthroplasty.

  Kenichi Kikuchi, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto

  The alignment philosophy in total knee arthroplasty (TKA) has tended to shift from the gold standard of mechanically aligned technique to personalized alignment, such as the kinematically aligned (KA) technique. However, the influences of different surgical techniques on lower limb alignment relative to the ground are not fully investigated. This study investigated the influence of the ankle and hindlimb alignment change after mechanically aligned TKA and KA-TKA. The varus osteoarthritic patients who underwent TKAs were divided into a mechanically aligned TKA group (group M, n = 50) and a KA-TKA group (group K, n = 50). Radiographic parameters (hip-knee-calcaneus [HKC] angle, hip-knee-ankle [HKA] angle, talar tilt angle [TTA], and tibiocalcaneal angle [TCA]) were investigated using full-length standing radiographs. The deviation angle (ΔTA; angle between the tibial mechanical axis [TMA] and the ground tibial mechanical axis [gTMA]) and the change of ΔTA (cΔTA) were also assessed. These parameters were compared between the two groups, along with the correlation between the preoperative HKA angle and other parameters. ΔTA, TTA, and TCA showed no differences between the groups pre- and postoperatively, and no significant changes were observed postoperatively. The preoperative HKA angle showed a significant negative correlation with cΔTA in both groups (group M: r = -0.33, p = 0.02; group K: r = -0.29, p = 0.04) although no correlation was observed the with preoperative TTA and TCA. Despite no change in ΔTA after surgery, the preoperative varus deformity was associated with a change in the deviation between gTMA and TMA after surgery. A severely varus knee may be inappropriate for ground KA-TKA.

  May 2024, The journal of knee surgery, 37(6) (6), 409 - 415, English, International magazine

  Scientific journal


• What effect does preoperative flexion contracture have on the component angles in unicompartmental knee arthroplasty?

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: The indication for unicompartmental knee arthroplasty (UKA) has been extended to cases with some degree of preoperative knee flexion contracture recently. The purpose of this study was to clarify the effect of flexion contracture on component angles. MATERIALS AND METHODS: Thirty-five fixed-bearing UKAs using the spacer block technique with preoperative flexion contracture (Group FC) and 35 UKAs using the same technique without preoperative flexion contracture (Group NC) were included. Using radiographs, the coronal femoral component angle, coronal tibial component angle, sagittal femoral component angle, and sagittal tibial component angle were determined. Also, extension and flexion angles of the knee as well as coronal Hip-Knee-Ankle (HKA) angles in long-leg standing radiographs were measured. The data about the thickness of the selected insert were also collected. The above results were compared between the two groups. RESULTS: The femoral component tended to be placed in a more varus and flexed position in Group FC, while no significant difference was found about the tibial component angles. While there was no significant difference in pre- and postoperative knee flexion angles between the two groups, flexion contracture remained postoperatively in Group FC. Preoperative HKA angle was greater in Group FC while the difference was no longer significant postoperatively. Regarding the thickness of the selected insert, thicker inserts tended to be used in Group FC. CONCLUSIONS: In fixed-bearing UKA with the spacer block technique, the femoral component tended to be placed in a flexed and varus position in the knees with preoperative flexion contracture.

  May 2024, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 34(4) (4), 2185 - 2191, English, International magazine

  Scientific journal


• Accuracy of portable navigation during THA in patients with severe developmental dysplasia of hip.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Ryosuke Kuroda

  INTRODUCTION: Correct cup placement in total hip arthroplasty (THA) for patients with developmental dysplasia of the hip (DDH) is considerably difficult. This study aimed to analyze the orientation accuracy of cup insertion during THA using a portable navigation system in patients with DDH. MATERIALS AND METHODS: In this retrospective cohort study, we analyzed data from 64 patients who underwent THA using infrared stereo camera-matching portable navigation. Patients underwent THA via the anterolateral approach in the lateral decubitus position. Navigation records for intraoperative cup angles, postoperative cup angles measured on computed tomography (CT) images, and cup angle measurement differences were measured and compared between patients with non-DDH/mild DDH and severe DDH. Furthermore, the predictive factors for outliers of accurate acetabular cup placement were analyzed. RESULTS: The average measurement absolute abduction differences (postoperative CT-navigation record) were 3.9 ± 3.5° (severe DDH) and 3.3 ± 2.6° (non-DDH/ mild DDH), and the anteversion differences were 4.7 ± 3.4° (severe DDH) and 2.3 ± 2.1° (non-DDH/ mild DDH). The anteversion difference was different between the two groups. Multivariate analysis showed that the navigation difference (absolute difference in anteversion between postoperative CT and navigation records of > 5°) was significantly associated with severe DDH (odds ratio [OR]: 3.3; p = 0.049, 95% confidence interval [CI]: 1.0-11.1) and posterior pelvic tilt (OR: 1.1; p = 0.042, 95% CI: 1.0-1.27). CONCLUSIONS: In patients with severe DDH, it is important to pay close attention during THA using portable navigation. However, the average difference was < 5º even in patients with severe DDH, and the accuracy may be acceptable in a clinical setting when the cost is considered.

  May 2024, Archives of orthopaedic and trauma surgery, 144(5) (5), 2429 - 2435, English, International magazine

  Scientific journal


• 人工膝関節全置換術後の細菌感染治療経過中に真菌感染をきたし、一期的に再置換術を施行した一例

  菅野 龍彦, 松本 知之, 中野 直樹, 壺坂 正徳, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 169 - 169, Japanese


• 【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について

  大江 啓介, 新倉 隆宏, 福井 友章, 隈部 洋平, 松本 知之, 黒田 良祐

  金原出版(株), Apr. 2024, 整形・災害外科, 67(5) (5), 681 - 687, Japanese


• Predicting postoperative coronal alignment after fixed-bearing unicompartmental knee arthroplasty using a new morphological assessment method: the arithmetic hip-knee-ankle angle.

  Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Only a few reports have been published so far on factors that predict postoperative coronal alignment after unicompartmental knee arthroplasty (UKA). The purpose of this study is to clarify the relationship between the arithmetic hip-knee-ankle angle (aHKA) and postoperative coronal alignment after medial fixed-bearing UKA. METHODS: One hundred and one consecutive patients (125 knees) who underwent medial fixed-bearing UKA were assessed. Pre- and postoperative coronal HKA angles, lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and the thickness of the tibial and femoral bone cut were measured. aHKA was calculated as 180° - LDFA + MPTA. Correlations between postoperative HKA angle and aHKA, LDFA, and MPTA were investigated by single regression analysis. After the patients were divided into three groups according to the postoperative HKA angle, i.e., HKA angle > 180°, 175° < HKA angle ≤ 180°, and HKA angle ≤ 175°, aHKA, LDFA, MPTA, preoperative HKA angle, and the thickness of the distal femoral as well as tibial bone cut were compared among the three groups. RESULTS: aHKA and MPTA were positively correlated with postoperative HKA angle, while no correlation was found between postoperative HKA angle and LDFA. Among the three groups classified by postoperative HKA angle, significant differences were found in aHKA, MPTA, and preoperative HKA angle, while no significant difference was found in LDFA and the amount of distal femoral and tibial osteotomies. CONCLUSIONS: aHKA was correlated with postoperative HKA angle after medial fixed-bearing UKA, which was probably due to the influence of MPTA.

  Apr. 2024, International orthopaedics, 48(4) (4), 889 - 897, English, International magazine

  Scientific journal


• Association Between Psychological Readiness to Return to Sports at 3 Months Postoperatively and Risk of Second ACL Injury.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  BACKGROUND: Psychological readiness to return to sports (RTS) has been associated with second anterior cruciate ligament (ACL) injury. However, this relationship is controversial because covariates such as anatomic and knee function characteristics have not been adequately considered. PURPOSE/HYPOTHESIS: To investigate whether psychological readiness in the early postoperative period can predict the occurrence of a second ACL injury within 24 months after primary ACL reconstruction (ACLR) using propensity score analysis. It was hypothesized that patients with high ACL-RSI after injury (ACL-RSI) scores at 3 months postoperatively would have a second ACL injury within the projected postoperative period. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Included were 169 patients who underwent primary ACLR using hamstring tendon autografts between November 2017 and July 2021 and also underwent knee functional assessments at 3 months postoperatively. The ACL-RSI scale was used to assess psychological readiness for RTS. A second ACL injury was defined if ipsilateral or contralateral ACL injury was confirmed by examination within 24 months postoperatively. Based on a previous study showing that 65 was the highest cutoff value for the ACL-RSI score for RTS, we classified patients into 2 groups: those with high ACL-RSI scores (≥65; group H) and those with low ACL-RSI scores (<65; group L). We generated 1-to-1 matched pairs using propensity score analysis and used log-rank testing to compare the rate of second ACL injury between the 2 groups. RESULTS: More patients returned to any sports activities within 12 months in group H than in group L (90% vs 73%; P = .03). A second ACL injury within 24 months postoperatively was identified in 7% of patients (13/169). The rate of second ACL injury was significantly higher in group H than in group L (17.6% vs 3.4%; P = .001). In 43 matched pairs extracted using propensity scoring, the rate of second ACL injury was also higher in group H than in group L (18.6% vs 4.7%; P = .04). CONCLUSION: Patients with a higher ACL-RSI score at 3 months exhibited a significantly higher incidence of second ACL injury within 24 months after primary ACLR.

  Apr. 2024, Orthopaedic journal of sports medicine, 12(4) (4), 23259671241239325 - 23259671241239325, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prediction of postoperative range of motion after mobile-bearing medial unicompartmental knee arthroplasty from the preoperative range of motion and other preoperative factors.

  Kensuke Anjiki, Takafumi Hiranaka, Toshikazu Tanaka, Takaaki Fujishiro, Koji Okamoto, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Postoperative flexion after unicompartmental knee arthroplasty might be predicted from the preoperative range of motion and other preoperative factors, but this has not been sufficiently investigated. METHODS: Between 2013 and 2017, 198 patients (198 knees) underwent unilateral knee arthroplasty with medial mobile-bearing unicompartmental knee arthroplasty. Range of motion was measured preoperatively and at the time of final follow-up. To investigate the accuracy of the prediction of preoperative to postoperative gain or loss of the flexion angle, we performed receiver operating characteristic analysis. Logistic regression analysis was used to evaluate other predictive factors. RESULTS: Change in flexion angle was significantly strongly and negatively correlated with the preoperative flexion angle (R= -0.688, 95%CI: -0.755, -0.607, P< 0.001). Preoperative flexion angle was suggested to be a significant predictor of gain or loss of the flexion angle with the area under the curve of 0.781; ,the cut-off value calculated using the Youden index was 140°. Logistic regression analysis showed that in addition to the preoperative flexion angle of the operated side, the postoperative flexion range was significantly affected by the patient's height and by the preoperative flexion angle of the contralateral knee. CONCLUSION: If the preoperative flexion angle in Oxford mobile-bearing medial unicompartmental knee arthroplasty is < 140°, the postoperative flexion angle may be improved; if it exceeds 140°, the postoperative flexion angle may worsen. This predictive ability is further improved by consideration of the patient's height and the range of motion on the contralateral side.

  Mar. 2024, The journal of knee surgery, English, International magazine

  Scientific journal


• AMED事業で進む運動器再生医療-臨床研究と医師主導治験- 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」

  黒田 良祐, 松本 知之, 大江 啓介, 福井 友章, 美舩 泰, 新倉 隆宏

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(3) (3), S1186 - S1186, Japanese


• Knee Osteotomy Decreases Joint Inflammation Based on Synovial Histology and Synovial Fluid Analysis.

  Shu Watanabe, Takehiko Matsushita, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To examine the biological changes in the joints of patients with knee osteoarthritis (OA) before and after around-knee osteotomy (AKO), focusing on synovial fluid (SF) and synovial pathological changes. METHODS: Patients who underwent AKO for medial compartment knee OA between 2019 and 2021 were examined. SF and synovium were obtained at the time of AKO and plate removal after bone union (mean, 16.8 months [range: 11-38 months] postoperatively). SF volume and interleukin (IL)-6 concentrations in SF were assayed using enzyme-linked immunosorbent assay. Synovitis was assessed histologically using a semiquantitative scoring system. Macrophage infiltration was assessed by immunohistochemistry using a semiquantitative score for F4/80 expression. The M1/M2 ratio was calculated using percentage of cells positive for CD80 and CD163. The expression of proinflammatory cytokines was assessed by the percentage of IL-1β- and IL-6-positive cells. The number of vascular endothelial growth factor-positive luminal structures was counted to assess angiogenesis. The change in each parameter was compared before and after AKO using the Wilcoxon matched-pairs signed-rank test. RESULTS: Twenty-four knees of 21 patients were included. SF volume and IL-6 concentration significantly decreased postoperatively (12.6 ± 2.1 mL vs 4.2 ± 0.6 mL; P < .0001 and 50.5 ± 8.6 pg/mL vs 20.7 ± 3.8 pg/mL; P = .0001, respectively). A significant reduction in synovitis score (P = .0001), macrophage infiltration (P < .0003), M1/M2 ratio (P < .0007), angiogenesis (P < .0001), and the percentage of IL-1β- and IL-6-positive cells in the intima (P < .008 and P < .002, respectively) was found after AKO. CONCLUSIONS: SF volume and IL-6 concentrations in the SF decreased and inflammatory synovium pathology improved after AKO. In addition to biomechanical changes, the biological environment of the joint can be improved after AKO. LEVEL OF EVIDENCE: Level IV, retrospective therapeutic case series.

  Mar. 2024, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 40(3) (3), 830 - 843, English, International magazine

  Scientific journal


• Mid- to Long-Term Results of Total Knee Arthroplasty for Charcot Arthropathy of the Knee.

  Yuma Onoi, Tomoyuki Matsumoto, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND: Total knee arthroplasty (TKA) for Charcot arthropathy of the knee is considered controversial because of its higher complication rate compared with that of TKA for osteoarthritis. In this study, we investigated the clinical outcomes, survival rates, and complications of primary TKA for Charcot arthropathy. METHODS: We conducted a retrospective analysis of nine patients (12 knees) with Charcot arthropathy who underwent TKA. The mean age of the patients was 63.9 ± 9.4 years (range, 52-83 years). The most frequent causative disease was diabetes mellitus (three patients). Patients' clinical outcomes, including the 2011 Knee Society Score and the range of motion, were compared between preoperative and the most recent postoperative data. The 5- and 10-year survival rates for aseptic revision, revision due to infection, and complications were examined. The mean follow-up period was 7.3 ± 3.9 years (range, 3-14 years). RESULTS: The 2011 Knee Society Score and the knee flexion angle significantly improved after TKA surgery (P < 0.05). The 5-year survival rates for aseptic revision, revision due to infection, and complications were 100%, 91.7%, and 83.3%, respectively; the 10-year survival rates for these parameters were the same. One patient underwent revision for insert replacement due to periprosthetic infection, and the other patient had varus/valgus instability due to soft tissue loosening. CONCLUSIONS: The mid- to long-term results of TKA for Charcot arthropathy were generally favorable. Our findings indicate that TKA may be a viable treatment option for Charcot arthropathy.

  Mar. 2024, Indian journal of orthopaedics, 58(3) (3), 308 - 315, English, International magazine

  Scientific journal


• LIGHT regulated gene expression in rheumatoid synovial fibroblasts.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA. METHODS: We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation. RESULTS: Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, integral to plasma membrane, intrinsic to plasma membrane, signal, plasma membrane, signal peptide, alternative splicing, and topological domain as extracellular. CONCLUSIONS: Our results indicate that LIGHT may regulate the expression in RA-FLS of genes which are important in the differentiation of several cell types and in cellular functions.

  Feb. 2024, Molecular biology reports, 51(1) (1), 356 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Varus placement of the tibial component reduces the potential risk of fracture with adequate bony coverage in the Oxford unicompartmental knee arthroplasty.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yoshihito Suda, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  A short keel-cortex distance (KCD), especially to the posterior cortex, is a potential risk factor for tibial plateau fracture after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to evaluate the effect of tibial component alignment in the coronal plane and tibial proximal morphology on the KCD. Included in this study were 51 patients scheduled for primary Oxford medial unicompartmental knee arthroplasty (UKA). The anterior and posterior KCD were preoperatively assessed using 3D simulation software with the component set perpendicular to the tibial mechanical axis (neutral), 3° valgus, 3° varus, and 6° varus, relative to neutral alignment. We evaluated the existence of overhanging medial tibial condyle where the medial eminence line, the line including the medial tibial eminence parallel to the tibial axis, passes outside of the tibial shaft. In all component alignments, patients with a medial overhanging condyle had significantly shorter posterior KCD than those without. In patients with a medial overhanging condyle, the posterior KCD significantly increased when the tibial component was placed in 3° varus (4.6 ± 1.5 mm, P = 0.003 vs neutral, P < 0.001 vs 3° valgus) and 6° varus (5.0 ± 1.4 mm, P < 0.001 vs neutral, P < 0.001 vs 3° valgus) compared with in neutral (3.5 ± 1.9 mm) or 3° valgus (2.8 ± 1.8 mm). In OUKA, varus implantation increased the KCD. This could potentially decrease the risk of fracture, even in knees with the overhanging medial condyle. Conversely, valgus implantation of the tibial component shortened the KCD, and should therefore be avoided.

  Jan. 2024, Scientific reports, 14(1) (1), 1274 - 1274, English, International magazine

  Scientific journal


• The severity of preoperative varus deformity affects the feasibility of correcting lower limb alignment with medial unicompartmental knee arthroplasty.

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: The relationship between the severity of preoperative varus deformity and the amount of its correction in unicompartmental knee arthroplasty (UKA) as well as the thickness of the insert has not been well known. METHODS: One hundred and three patients who underwent medial fixed-bearing UKA with the use of the spacer block method were assessed. After the component gap in extension was measured using a UKA tensor, the pre-osteotomy gap was calculated from the thickness of the bone cuts. The relationship between the preoperative hip-knee-ankle (HKA) angle as well as the pre-osteotomy gap and the amount of change in HKA angle were analysed. Also, preoperative HKA angle and the thickness of the bone cuts were compared among groups by the insert thickness. RESULTS: The mean preoperative HKA angle was 7.7 ± 3.1° varus. Patients with more varus deformity and those with a wider pre-osteotomy gap showed a more valgus change in HKA angle. As for the thickness of the insert, the preoperative HKA angle of the patients with the thinnest insert was significantly smaller (less varus) than that of those with the thicker insert while no statistically significant difference was found among the insert groups regarding the amount of the bone cuts. CONCLUSIONS: The severity of the preoperative varus deformity as well as the intraoperative pre-osteotomy gap related to the amount of change in HKA angle. As thick inserts tended to be used in severe varus knees, the tibial bone cut can be reduced in such cases.

  Jan. 2024, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29(1) (1), 183 - 187, English, Domestic magazine

  Scientific journal


• Krüppel-like factor 15 deficiency exacerbates osteoarthritis through reduced expression of peroxisome proliferator-activated receptor gamma signaling in mice.

  Kemmei Ikuta, Shinya Hayashi, Kenichi Kikuchi, Masahiro Fujita, Kensuke Anjiki, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Tomoyuki Matsumoto, Tetsuya Hosooka, Wataru Ogawa, Ryosuke Kuroda

  OBJECTIVE: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). METHODS: 0Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining were performed. Morphological changes were measured using microcomputed tomography. Six mice from each group were analyzed (total number of mice analyzed: 60). In vitro, immunofluorescence, quantitative reverse transcription-polymerase chain reaction, and western blot analyses were performed. RESULTS: KLF15 KO DMM mice exhibited significant cartilage degradation compared to WT mice. According to the Osteoarthritis Research Society International cartilage OA-histopathology scoring system, the mean sum score in KLF15 KO mice was significantly higher than that in WT mice at 8 weeks after surgery. Immunohistochemistry results revealed KLF15 KO mice exhibited reduced peroxisome proliferator-activated receptor gamma (PPARγ) expression, increased pIKKα/β, a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) 5, and Matrix metalloproteinases (MMP13) expression, and reduced Forkhead box O (FOXO1) and Light chain 3B (LC3B) expression. Inhibition of PPARγ phosphorylation accelerated the effects of interleukin (IL) 1β-treatment in both KLF15 KO and WT chondrocytes, and activation of PPARγ expression canceled the IL1β-induced catabolic effects. CONCLUSION: Our results indicated that the OA phenotype of KLF15 KO DMM mice was influenced by reduced PPARγ expression, including enhanced pIKKα/β, ADAMTS5, and MMP13 expression, reduced autophagy, and increased apoptosis. KLF15 regulation may constitute a possible therapeutic strategy for the treating OA.

  Jan. 2024, Osteoarthritis and cartilage, 32(1) (1), 28 - 40, English, International magazine

  Scientific journal


• Clinical use of autologous adipose-derived stromal vascular fraction cell injections for hip osteoarthritis.

  Yuma Onoi, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Shinya Hayashi, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  INTRODUCTION: Currently, studies on adipose-derived stromal vascular fraction (SVF) cells are attracting increasing attention because they have the potential to differentiate into a subset of cell types, such as bone marrow-derived mesenchymal stromal cells (MSCs), and are easier to harvest than MSCs, thus making them easier to apply clinically. This study evaluated the short-term clinical outcomes of SVF cell therapy for hip osteoarthritis (OA). METHODS: Forty-two patients were enrolled in this study; these patients received a single injection comprising an average of 3.8 (standard deviation [SD], ±1.3) × 107 SVF cells into the hip joint. All patients were followed-up for at least 6 months. The mean age of the patients was 60.2 years (SD, ±9.4 years). Kellgren-Lawrence (KL) grades II, III, and IV based on radiography were 13, 13, and 16 patients, respectively. SVF cells were obtained from the subcutaneous fat of the abdomen or breech using a Celution® 800/CRS system. The average cell viability of SVF cells was 90.8% (SD, ±2.8%). Clinical assessments were performed using the Harris Hip Score (HHS), Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) score, and visual analog scale (VAS) score to evaluate pain. Images were evaluated using radiography, and T2 mapping values were obtained using a 1.5-T magnetic resonance imaging system. These clinical and imaging assessments were followed from preoperatively to 6 months postoperatively. RESULTS: The HHS, JHEQ score, and VAS score improved significantly from 22.5 (SD, ±16.6), 26.6 (SD, ±11.3), and 75.5 (SD, ±15.8) preoperatively to 46.8 (SD, ±27.2), 39.4 (SD, ±19.7), and 46.5 (SD, ±27.9), respectively, at 6 months postoperatively. KL grade II showed significant improvement in clinical outcome from preoperative to postoperative, while KL grade IV showed slight or little improvement. The center edge angle, acetabular head index on the radiographs, and T2 mapping values did not change significantly from preoperatively to 6 months postoperatively. CONCLUSIONS: SVF cell injection in the hip joint showed good short-term clinical efficacy for reducing hip OA symptoms. SVF cell therapy is thus an innovative and effective treatment for hip OA.

  Dec. 2023, Regenerative therapy, 24, 94 - 102, English, International magazine

  Scientific journal


• Accuracy comparison of cup positioning during total hip arthroplasty using Hip Align and AR-Hip in the supine position.

  Masahiro Fujita, Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Toshihisa Maeda, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  INTRODUCTION: The aim of this study is to compare the accuracy of acetabular cup positioning between the accelerometer-based navigation system and the augmented reality-based navigation system during THA in the supine position. MATERIALS AND METHODS: This retrospective study included 66 patients (70 hips) who underwent THA using two types of portable navigation system, Hip Align or AR-Hip, in the spine position. The absolute difference between the intraoperative navigation record and postoperative measurement using computed tomography data was evaluated. Preoperative clinical factors that decreased the accuracy of cup positioning by ≥ 3° were analyzed via multiple logistic regression analyses. RESULTS: The average absolute error of inclination was 2.8 ± 2.6° in Hip Align and 2.7 ± 1.8° in AR-Hip, and absolute anteversion error was 2.5 ± 2.0° in Hip Align and 2.6 ± 2.2° in AR-Hip, and there was no significantly different between the two navigation systems. There was a significant association between the absolute measurement error (≥ 3°) of cup inclination and patients' BMI in the Hip Align group [odds ratio (OR) 1.350; 95% confidence interval (CI) 1.035-1.760; p = 0.027], but not in the AR-Hip group. CONCLUSIONS: The accuracy of the acetabular cup positioning between the Hip Align and AR-Hip showed no difference during THA in the spine position. The high BMI could have negative influence on the accuracy of cup positioning in THA using Hip Align, thus AR-Hip could be designable for obesity patients.

  Dec. 2023, Archives of orthopaedic and trauma surgery, 143(12) (12), 7229 - 7235, English, International magazine

  Scientific journal


• Successful Total Knee Arthroplasty for Hoffa and Proximal Tibial Fractures: Report of Three Complex Cases After Failed Osteosynthesis Procedures.

  Takuma Maeda, Tomoyuki Matsumoto, Masahiro Fujita, Masanori Tsubosaka, Tomoyuki Kamenaga, Naoki Nakano, Yuichi Kuroda, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND Distal femoral and proximal tibial fractures often lead to nonunion and post-traumatic osteoarthritis, and total knee arthroplasty (TKA) has emerged as an effective alternative for older patients. This report includes 3 cases of successful TKA treatment. The cases involve a 42-year-old man and a 62-year-old man with Hoffa coronal fractures of the distal femur, and a 50-year-old man with a proximal tibial fracture. These patients underwent multiple osteosynthesis procedures before receiving TKA. CASE REPORT Case 1: A 42-year-old man with a displaced Hoffa's fracture had persistent knee pain. Nonunion post-initial fixation led to reoperation with iliac bone grafting and plate fixation. TKA using a Posterior Stabilized (PS)-type implant resulted in improved motion and function after 3 years. Case 2: A 62-year-old man suffered lateral condyle and ligament injuries from a displaced Hoffa's fracture. Despite plate fixation, dislocation occurred, requiring conversion. TKA with long-stem hinge-type implant, using augmentation block, led to enhanced stability and outcomes at 2 years. Case 3: A 50-year-old man's tibial nonunion, treated with plate fixation, resulted in infection and bone fusion. TKA using a constrained PS-type implant insert addressed the lateral tibial adhesions via iliotibial band (ITB) release and treated severe tibial plateau damage. Positive results were seen at 1 year. CONCLUSIONS The challenges of pseudarthrosis, like bone defects and compromised tissue, highlight the need for precise implant selection based on evaluations of bone quality, defects, knee stability, and hyperextension, rather than resorting to overly-constrained implants.

  Nov. 2023, The American journal of case reports, 24, e941187, English, International magazine

  Scientific journal


• Comparison study of periprosthetic bone remodeling between simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty: a matched cohort study.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda

  PURPOSE: The load-bearing pattern of periprosthetic bone may differ between patients who underwent simultaneous bilateral and unilateral total hip arthroplasty (THA). We investigated the differences in periprosthetic bone remodeling after simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty. METHODS: This retrospective cohort study enrolled 154 consecutive patients undergoing THA using full hydroxyapatite (HA) compaction short stems. Patient characteristics including age, body mass index, University of California Los Angeles (UCLA) activity score, and bone shape of the proximal femur were adjusted by propensity score matching. Subsequently, periprosthetic bone mineral density changes were compared between simultaneous bilateral and unilateral THA. RESULTS: We found that bone mineral density loss in the simultaneous bilateral THA group was significantly higher in zones 6 and 7 at 24 months after THA (zone 6, p = 0.019; zone 7, p = 0.041). Periprosthetic bone mineral density loss was not associated with clinical factors, including age, body mass index, and daily activity. Additionally, we demonstrated that periprosthetic bone mineral density loss was higher in zones 1, 4, 6, and 7 of patients with a normal hip on the contralateral side after unilateral THA (zone 1, p = 0.041; zone 4, p = 0.041; zone 6, p = 0.037; zone7, p = 0.019). CONCLUSIONS: The postoperative periprosthetic bone remodeling was lower in patients who underwent simultaneous bilateral THA than in those who underwent unilateral THA, even though patient characteristics were adjusted by propensity matching. Further observation of periprosthetic bone mineral density loss is needed to clarify the differences between the groups.

  Nov. 2023, International orthopaedics, 47(11) (11), 2767 - 2772, English, International magazine

  Scientific journal


• Pseudarthrosis of Pelvic Fracture With Charcot Arthropathy Successfully Treated With Constrained Total Hip Arthroplasty.

  Toshiki Kitamura, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Naoki Nakano, Yuichi Kuroda, Takahiro Niikura, Ryosuke Kuroda

  Charcot arthropathy is a rapidly progressive and destructive form of arthropathy caused by various neurological diseases. Total hip arthroplasty (THA) is usually contraindicated in patients with Charcot arthropathy; however, recent studies have reported good results following THA in this patient population. Herein, we report a case of Charcot arthropathy secondary to syphilis in a patient who was successfully treated with constrained THA, a new type of THA. A 56-year-old man was injured in a car accident, and a displaced acetabular fracture was revealed three weeks later. He was treated conservatively but soon developed greater displacement of the fracture and femoral head destruction. The patient was referred to our hospital for further treatment. The patient had pelvic pseudarthrosis secondary to Charcot arthropathy at the time of the first visit to our hospital. First, THA was performed with the acetabular reconstruction of the deficient bone. However, the acetabular implant was displaced one week postoperatively. THA revision was performed using a constrained cup. Postoperatively, the patient exhibited good hip stability without dislocation. However, displacement of the acetabular cup occurred one year after the second surgery. We performed a re-revision of THA using a new type of constrained cup that offers a high level of constraint to maintain range of motion (ROM) and prevent dislocations. The patient was able to walk with a T-cane one year postoperatively. Herein, we report a difficult case of revision THA in a patient with Charcot arthropathy concomitant with syphilis. THA is usually contraindicated in patients with Charcot arthropathy; however, we propose that THA using constrained cups that offer a wider ROM may be a useful therapeutic strategy for the treatment of Charcot arthropathy.

  Nov. 2023, Cureus, 15(11) (11), e48295, English, International magazine


• Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair.

  Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

  BACKGROUND: We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. METHODS: CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the results of the phase I/II study. An independent data monitoring committee performed the radiographic assessments. Adverse events and medical device failures were recorded. RESULTS: All fractures healed during the study period. The time to radiological fracture healing was 2.8 times shorter in patients with CD34 + cell transplantation than in the historical control group (hazard ratio: 2.81 and 95% confidence interval 1.16-6.85); moreover, no safety concerns were observed. CONCLUSIONS: Our findings strongly suggest that autologous CD34 + cell transplantation is a novel treatment option for fracture nonunion. TRIAL REGISTRATION: UMIN-CTR, UMIN000022814. Registered on 22 June 2016.

  Oct. 2023, BMC medicine, 21(1) (1), 386 - 386, English, International magazine

  Scientific journal


• Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis.

  Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda

  The stromal-vascular fraction (SVF), comprising heterogeneous cell populations and adipose-derived stromal cells (ADSCs), has therapeutic potential against osteoarthritis (OA); however, the underlying mechanism remains elusive. This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit SVF on rabbit chondrocytes. Rabbit SVF and ADSCs were autografted into knees at OA onset. The SVF (1 × 105) and low-dose ADSCs (lADSC; 1 × 104) groups adjusted for their stromal cell content were compared. Animals were euthanized 8 and 12 weeks after OA onset for macroscopic and histological analyses of OA progression and synovitis. Immunohistochemical and real-time polymerase chain reaction assessments were conducted. In vitro, immune-fluorescent double staining was performed for SVF to stain macrophages with F4/80, CD86(M1), and CD163(M2). OA progression was markedly suppressed, and synovitis was reduced in the SVF groups (OARSI histological score 8 W: 6.8 ± 0.75 vs. 3.8 ± 0.75, p = 0.001; 12 W: 8.8 ± 0.4 vs. 5.4 ± 0.49, p = 0.0002). The SVF groups had higher expression of collagen II and SOX9 in cartilage and TGF-β and IL-10 in the synovium, lower expression of MMP-13, and lower macrophage M1/M2 ratio than the lADSC groups. Immunofluorescent double staining revealed a markedly higher number of M2 than that of M1 macrophages in the SVF. The therapeutic effects of SVF on chondrocytes were superior than those of lADSCs, with enhanced anabolic and inhibited catabolic factors. Heterogeneous cells, mainly M2 macrophages in the SVF, enhanced growth factor secretion and chondrocyte-protective cytokines, thus benefiting chondrocytes and knee joint homeostasis. Overall, the SVF is a safe, relatively simple, and a useful treatment option for OA.

  Oct. 2023, Stem cell reviews and reports, 19(7) (7), 2407 - 2419, English, International magazine

  Scientific journal


• Targeting the neutral hip-to-calcaneus axis in kinematically aligned total knee arthroplasty is feasible with fewer alignment outliers for varus osteoarthritic patients.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Toshihisa Maeda, Shotaro Tachibana, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  PURPOSE: Assessment of the conventional mechanical axis (MA) (hip-to-talus axis) is reported to result in constitutional varus in the native knee. However, the ground MA (hip-to-calcaneus axis), which is the line from the hip center to the bottom of the calcaneus, passes through the center of the knee joint in the native knee and is a possible alternative target for total knee arthroplasty (TKA) assessments. Therefore, this study aimed to present a "ground kinematically aligned (KA)-TKA." In this technique, the femoral component is placed on the cylindrical axis using the calipered technique and the tibial component is placed to give a neutral ground MA. Radiographical investigation was used to determine whether physiological alignment can be individually achieved with ground KA-TKA; this was compared with that of a tibia-restricted modified KA-TKA, referring to conventional MA (hip-to-talus axis) results. METHODS: As the primary endpoint, this prospective cohort study compared the ground MA ratios of the knee joints in 40 ground KA-TKAs (G group: Coronal Plain Alignment of the Knee (CPAK) 28 type I, 7 II, 1 IV, and 4 V) with those of the preceding 60 modified KA-TKAs (M group: CPAK 46 type I, 12 II, and 2 V) performed for patients with varus osteoarthritis (OA). The number of outliers differing over ± 5% from the neutral were compared between groups using the χ2-test. The Hip-knee-ankle (HKA) angle, coronal femoral/tibial component alignment (FCA/TCA), and joint line orientation angle (JLOA) were compared between the groups using non-paired t-tests. Statistical significance was set at p < 0.05. RESULTS: The G group had a higher ratio of the ground MA passing through the knee center than the M group did; outliers differing over ± 5% from the neutral of the ground MA were 2/40 cases in the G group and 20/60 cases in the M group, which was a significant difference (p = 0.001). The HKA angle, FCA/TCA, and JLOA were not significantly different between the groups. CONCLUSIONS: Targeting the ground MA in KA-TKA for patients with varus OA was feasible and has the potential to provide a physiological alignment more similar to the native knee in TKA than other kinematic alignment techniques. LEVEL OF EVIDENCE: Level III.

  Sep. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(9) (9), 3880 - 3888, English, International magazine

  Scientific journal


• Ground kinematically aligned total knee arthroplasty: new personalized technique which enables a stable knee with deep flexion.

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yuichi Kuroda, Shinya Hayashi, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to evaluate kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) (hip-to-calcaneus axis), the line from the hip centre to the bottom of the calcaneus, (ground KA-TKA) in terms of its comparison with tibia-restricted modified KA-TKA (modified KA-TKA). METHODS: This retrospective cohort study included 106 consecutive patients who underwent unilateral KA-TKA for varus osteoarthritis (OA) (60 modified KA-TKAs and 46 ground KA-TKAs). After 1:1 propensity score matching, 60 patients (30 pairs) were matched between the groups with comparable demographic data. The hip-knee-ankle (HKA) angle, coronal femoral component alignment (FCA), and coronal tibial component alignment (TCA) were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance, was also compared between the groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score, were compared between groups. RESULTS: The HKA angle and FCA/TCA were not significantly different between groups. Whereas the varus/valgus balance showed no significant differences between groups, smaller joint component gaps were found throughout the range of motion in the ground KA-TKA group than in the modified KA-TKA group. Despite no difference in clinical scores between groups, a significantly deeper postoperative flexion angle was achieved in the ground KA-TKA group than in the modified KA-TKA group (p < 0.05). CONCLUSION: Targeting neutral ground MA in KA-TKA for patients with varus OA has the potential to provide a better flexion angle with stable intraoperative soft tissue balance.

  Sep. 2023, International orthopaedics, 47(9) (9), 2215 - 2223, English, International magazine

  Scientific journal


• 【変わりゆくTKAのトレンド】Functional alignmentの実際

  石田 一成, 柴沼 均, 中野 直樹, 松本 知之, 黒田 良祐

  (株)メジカルビュー社, Sep. 2023, 関節外科, 42(9) (9), 985 - 990, Japanese


• Combining age, sex, body mass index, sport level, and preoperative quadriceps strength improves the predictive ability of quadriceps strength recovery after anterior cruciate ligament reconstruction.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Kyohei Nishida, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  PURPOSE: This study compared the predictive ability of each independent predictor with that of a combination of predictors for quadriceps strength recovery one year after anterior cruciate ligament (ACL) reconstruction. METHODS: Patients who underwent primary ACL reconstruction using hamstring autografts were enrolled. Quadriceps strength, hamstring strength, and anterior tibial translation were measured, and the limb symmetry index (LSI) of the quadriceps and the hamstrings was calculated preoperatively and one year after surgery. Patients were classified into two groups according to the LSI of the quadriceps strength at one year postoperatively (≥ 80% or < 80%). Multivariate logistic regression analysis identified the independent predictors of quadriceps strength recovery, and the cut-off value was calculated using the receiver operating characteristic curve. A model assessing predictive ability of the combination of independent predictors was created, and the area under the curve (AUC) for each independent predictor was calculated by using the receiver-operating characteristic curves and the DeLong method. RESULTS: Of the 646 patients, 414 (64.1%) had an LSI of at least 80% for quadriceps strength one year after surgery, and 232 patients (35.9%) had an LSI of < 80%. Age, sex, body mass index (BMI), preinjury sport level, and LSI of preoperative quadriceps strength were independently associated with quadriceps strength recovery one year after ACL reconstruction. The cut-off values were age: 22.5 years; sex: female; BMI: 24.3 kg/m2; preinjury sport level: no sport; and LSI of preoperative quadriceps strength: 63.3%. The AUC of the model assessing the predictive ability of the combination of age, sex, BMI, preinjury sport level, and LSI of preoperative quadriceps strength was significantly higher (0.73) than that of similar factors of preoperative quadriceps strength (AUC: 0.63, 0.53, 0.56, 0.61, and 0.68, p < 0.01, respectively). CONCLUSION: The combination of age, sex, BMI, preinjury sport level, and LSI of preoperative quadriceps strength had a superior predictive ability for quadriceps strength recovery at one year after ACL reconstruction than these predictors alone. Multiple factors, including patient characteristics and preoperative quadriceps strength, should be considered when planning rehabilitation programs to improve quadriceps strength recovery after ACL reconstruction. LEVEL OF EVIDENCE: III.

  Jun. 2023, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prosthetic orientation, limb alignment, and soft tissue balance with bi-cruciate stabilized total knee arthroplasty: a comparison between the handheld robot and conventional techniques.

  Tomoyuki Matsumoto, Naoki Nakano, Shinya Hayashi, Koji Takayama, Toshihisa Maeda, Kazunari Ishida, Yuichi Kuroda, Takehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  PURPOSE: This study aimed to examine the prosthetic orientations, limb alignment, intraoperative soft tissue balance, and early clinical outcomes associated with the use of the relatively new handheld robot technique compared to those associated with the use of the conventional alignment guide for bi-cruciate stabilized total knee arthroplasty (TKA). METHODS: This retrospective cohort study compared the prosthetic orientation and limb alignment of 35 patients who underwent TKA using robotic assistance (robot group) with those of patients who underwent TKA using a conventional alignment guide (control group). The coronal femoral component alignment (FCA), coronal tibial component alignment (TCA), and the hip-knee-ankle (HKA) angle were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance assessed by an offset-type tensor, were also compared between groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score (KSS), were compared between groups. RESULTS: The HKA angle and FCA were 0.1° varus and 0.1° varus, respectively, in the robot group and 1.3° varus and 1.3° varus, respectively, in the control group. The difference in the HKA angle and the FCA, but not the TCA, between groups was statistically significant (p < 0.05). The intraoperative soft tissue balance showed more stable joint component gaps and varus/valgus balances throughout the range of motion in the robot group than in the control group. Clinical outcomes of the robot group showed superior 2011 KSS subscales compared to those of the control group. CONCLUSION: The accuracy of the implantations and stable soft tissue balance in the robot group were superior to those of the control group. The robot group also had superior patient-reported scores for early clinical outcomes.

  Jun. 2023, International orthopaedics, 47(6) (6), 1473 - 1480, English, International magazine

  Scientific journal


• Mobile bearing orbit on the tibial component in Oxford unicompartmental knee arthroplasty.

  Yoshihito Suda, Takafumi Hiranaka, Tomoyuki Kamenaga, Takaaki Fujishiro, Koji Okamoto, Tomoyuki Matsumoto

  PURPOSE: To evaluate the bearing orbit of the tibial component during extension-flexion motion in Oxford unicompartmental knee arthroplasty. MATERIALS AND METHODS: A total of 32 knees in 25 patients with medial osteoarthritis who underwent Oxford unicompartmental knee arthroplasty were evaluated. The distance between the vertical wall of the tibial component and the bearing (wall-bearing distance) and that between the anterior edge of the tibial component and the bearing (sagittal bearing position) were measured at 0°, 30°, 60°, 90° and 120° knee flexion with neutral tibial rotation (extension-flexion motion), and internal and external tibial rotation with 90° knee flexion (tibial rotation motion). A custom-made rounded trial bearing and caliper were used for this measurement. We calculated the wall-bearing distance, change in extension-flexion motion and tibial rotation motion. Wall-bearing distances and change in wall-bearing distance were compared using ANOVA or t-test. RESULTS: The wall-bearing distance was smallest at 60° and increased 1.0 ± 1.1 mm in knee extension and 1.1 ± 1.5 mm in knee flexion. The bearing moved posteriorly with knee flexion, and the sagittal bearing position increased by 8.1 ± 3.4 mm during extension-flexion motion. Consequently, the bearing moved in a rough C-shaped orbit of the tibial component. CONCLUSIONS: The mobile bearing moves in a rough C-shape and is mostly close to the vertical wall of the tibial component at 60°. The wall-bearing distance can change during extension-flexion motion and might be influenced by tibial component rotation. To avoid bearing separation from or contact with the vertical wall that may cause bearing dislocation, the wall-bearing distance should be evaluated before keel slot preparation.

  Jun. 2023, The Knee, 42, 136 - 142, English, International magazine

  Scientific journal


• Acute Deterioration of Patient with Sudden Onset of Shock Caused by Group G Streptococcus Infection after Revision Total Knee Arthroplasty: A Case Report.

  Kensuke Wada, Tomoyuki Matsumoto, Kemmei Ikuta, Masanori Tsubosaka, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda

  BACKGROUND Periprosthetic joint infection is a difficult complication, especially in patients with rheumatoid arthritis. Life-threatening septic shock due to periprosthetic joint infection caused by group G streptococcus is rare, and there have been few reports about its treatment. We describe a successful case of sudden onset septic shock due to group G Streptococcus infection after revision total knee arthroplasty. CASE REPORT A 61-year-old woman with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs for about 12 years presented with acute right knee pain and shock 6 months after revision total knee arthroplasty. Periprosthetic joint infection caused by group G Streptococcus was diagnosed. She was admitted to the Intensive Care Unit, treated with respiratory support and dialysis, and underwent irrigation, debridement, and polyethylene liner exchange as the first surgery. At 9 days after the first surgery, she underwent the second surgery, consisting of implant removal and antibiotic spacer placement due to failure. It took approximately 7 weeks to normalize the levels of systemic markers of inflammation with intravenous antibiotics and then oral antibiotics for further 12 weeks, but re-revision total knee arthroplasty was successfully performed 1.5 years later. At a 1-year follow-up from the final surgery, she was able to walk with a cane and had no symptoms of infection. CONCLUSIONS In such cases with sudden onset of septic shock due to periprosthetic joint infection, appropriate and prompt surgical treatment should be performed to save the infected limb as well as the patient's life.

  Apr. 2023, The American journal of case reports, 24, e938905, English, International magazine

  Scientific journal


• Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.

  Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.

  Apr. 2023, Injury, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【人工関節における進歩】手術支援技術 ナビゲーション 簡易ナビゲーション 人工股関節全置換術における簡易ナビゲーションの有用性

  林 申也, 黒田, 雄一, 中野 直樹, 松本 知之, 黒田 良祐

  Apr. 2023, 別冊整形外科, (83) (83), 139 - 142, Japanese


• Revision surgery in a middle-aged patient with pertrochanteric fracture nonunion due to wedge effect caused by cephalomedullary nail: A case report.

  Takahiro Waki, Tomohiro Matsumura, Genta Fukumoto, Toshiharu Takami, Tomonori Yano, Kenjiro Ito, Shinji Matsushima, Tomoyuki Matsumoto, Ryosuke Kuroda

  Trochanteric femur fractures have traditionally been treated surgically with compression hip screws or cephalomedullary nails. With the increasing use of cephalomedullary nails, potential complications from this technique have surfaced. One of them is the potential for varus malreduction of trochanteric femur fractures, known as the "wedge effect", which is the distraction of fracture fragments generated during reamer and nail passage resulting in varus malalignment at the neck-shaft angle. Although trochanteric nonunion in the non-elderly is exceedingly rare, we experienced one such case after nailing due to the wedge effect that was subsequently successfully treated with a compression hip screw without bone grafting. Therefore, in the case of stable pertrochanteric fractures (AO/OTA 31A1) in younger patients, compression hip screw surgery may be the better choice of initial surgery to avoid later nonunion.

  Apr. 2023, Trauma case reports, 44, 100785 - 100785, English, International magazine


• Nonunion of Hoffa Fracture Successfully Treated by Total Knee Arthroplasty: A Case Report.

  Toshiki Kitamura, Tomoaki Fukui, Tomoyuki Matsumoto, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.

  Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Total knee arthroplasty for severe valgus deformity of the knee with extra-articular deformities of the femur and tibia using a 3-dimensional image matching software system.

  Kemmei Ikuta, Tomoyuki Matsumoto, Naoki Nakano, Shintaro Mukohara, Shinya Hayashi, Ryosuke Kuroda

  INTRODUCTION AND IMPORTANCE: Knee osteoarthritis with femoral and/or tibial extra-articular deformities makes total knee arthroplasty (TKA) technically difficult to perform, especially using intramedullary-based instrumentation systems. The Athena Knee 3-dimensional (3-D) image matching software is effective for TKA with an extra-articular deformity, especially in case of using a long-stem prosthesis or not available computer-assisted navigation systems. CASE PRESENTATION: A 79-year-old woman presented with right knee pain secondary to a progressive valgus deformity and gait disturbance. She had experienced a supracondylar femoral fracture fifteen years ago, and a tibial shaft fracture ten years ago on the same side; both of fractures were treated surgically. She had a severe valgus knee deformity and extra-articular deformity of femur and tibia, and valgus stress test detected medial knee instability. The range of motion was 0° in extension and 75° in flexion. Severe medial knee laxity compelled us to use a constrained and long-stem prosthesis, resulting in the use of an intramedullary guided system. The 3-D software system helped us to determine the amount of bone to cut as well as the appropriate entry points for the intramedullary rods and mechanical axis restoration. At two years after surgery, knee range of motion improved to 90° in flexion, and walking ability had also advanced from the use of two crutches to that of a T cane. CONCLUSION: The 3-D image matching software system for preoperative planning was useful for TKA with extra-articular deformity, especially in the case of a long-stem prosthesis without using a navigation system.

  Feb. 2023, International journal of surgery case reports, 103, 107853 - 107853, English, International magazine


• The efficiency of genetically modified mesenchymal stromal cells combined with a functionally graded scaffold for bone regeneration in corticosteroid-induced osteonecrosis of the femoral head in rabbits.

  Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Seyedsina Moeinzadeh, Elijah Ejun Huang, Junichi Kushioka, Hirohito Hirata, Charu Jain, Hunter W Storaci, Calvin Chan, Masakazu Toya, Qi Gao, Victoria Teissier, Huaishuang Shen, Xueping Li, Ning Zhang, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B Goodman, Yunzhi Peter Yang

  Core decompression (CD) with mesenchymal stromal cells (MSCs) is an effective therapy for early-stage osteonecrosis of the femoral head (ONFH). Preconditioning of MSCs, using inflammatory mediators, is widely used in immunology and various cell therapies. We developed a three-dimensional printed functionally graded scaffold (FGS), made of β-TCP and PCL, for cell delivery at a specific location. The present study examined the efficacy of CD treatments with genetically modified (GM) MSCs over-expressing PDGF-BB (PDGF-MSCs) or GM MSCs co-over-expressing IL-4 and PDGF-BB and preconditioned for three days of exposure to lipopolysaccharide and tumor necrosis factor-alpha (IL-4-PDGF-pMSCs) using the FGS for treating steroid-induced ONFH in rabbits. We compared CD without cell-therapy, with IL-4-PDGF-pMSCs alone, and with FGS loaded with PDGF-MSCs or IL-4-PDGF-pMSCs. For the area inside the CD, the bone volume in the CD alone was higher than in both FGS groups. The IL-4-PDGF-pMSCs alone and FGS + PDGF-MSCs reduced the occurrence of empty lacunae and improved osteoclastogenesis. There was no significant difference in angiogenesis among the four groups. The combined effect of GM MSCs or pMSCs and the FGS was not superior to the effect of each alone. To establish an important adjunctive therapy for CD for early ONFH in the future, it is necessary and essential to develop an FGS that delivers biologics appropriately and provides structural and mechanical support.

  Jan. 2023, Journal of biomedical materials research. Part A, 111(8) (8), 1120 - 1134, English, International magazine

  Scientific journal


• Clinical and Radiological Comparison of Single and Double Intra-articular Injection of Adipose-Derived Stromal Vascular Fraction for Knee Osteoarthritis.

  Masahiro Fujita, Tomoyuki Matsumoto, Satoshi Sobajima, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  The aim of the article is to compare the clinical and radiological outcomes between single and double stromal vascular fraction (SVF) cell injections in patients with knee osteoarthritis (OA). We included 54 patients treated for varus knee OA with intra-articular SVF cell injection. They were divided into two groups: those who received one injection and those who received two. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, knee range of motion, and knee muscle force were assessed at baseline and 3, 6, 12, and 24 months after the first injection. The preoperative hip-knee-ankle (HKA) angle was evaluated using plain radiographs, and T2 mapping values were assessed. The total WOMAC score improved significantly in the single injection group from 3 to 24 months, but the total WOMAC score in the double injection group improved significantly at 24 months. The T2 mapping values in both the groups improved, with a significant difference at 12 months. The preoperative mean HKA angle and the correlation coefficients between the HKA angle and the total WOMAC score and between the HKA angle and the T2 mapping value of the medial femur were significant. In conclusion, double injections may provide more satisfactory treatment outcomes in patients with severe varus knee alignment. This clinical trial is registered in the Japanese Ministry of Health, Labour and Welfare (URL: https://saiseiiryo.mhlw.go.jp/published_plan/index/2) with the registration name "Cell transplantation therapy for osteoarthritis using autologous subcutaneous adipose tissue-derived regenerative (stem) cells (ADRCs)," and the registration number was "PB5160012."

  2023, Cell transplantation, 32, 9636897231190175 - 9636897231190175, English, International magazine

  Scientific journal


• Reliability and Validity of Quadriceps Muscle Thickness Measurements in Ultrasonography: A Comparison with Muscle Mass and Strength

  Ogawa M, Matsumoto T, Harada R, Yoshikawa R, Ueda Y, Takamiya D, Sakai Y

  Japanese Association of Rehabilitation Medicine, 2023, Progress in Rehabilitation Medicine, 8, n/a - n/a, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Outcomes of palliative surgery for bone metastasis of metastatic renal cell carcinoma in the era of targeted therapy.

  Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Ryoko Sawada, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Tomoaki Terakawa, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  INTRODUCTION: The introduction of tyrosine kinase inhibitors has revolutionized treatment strategies for metastatic renal cell carcinoma (RCC) and has improved survival rates. The number of patients with bone metastases from RCC requiring surgery will increase as survival rates improve. However, there is insufficient evidence to standardize the treatment of bone metastases after the introduction of targeted therapy for metastatic RCC. We aimed to determine the outcomes of palliative surgical treatment of bone metastases in the extremities of patients with metastatic RCC. MATERIALS AND METHODS: We retrospectively reviewed 26 lesions from 17 patients who underwent surgery for extremity and acetabular bone metastases and were treated with targeted therapies for advanced RCC between 2008 and 2020. The median follow-up duration was 19 months (range, 4-76). We assessed the patients' activities of daily living, quality of life, and pain and analyzed their postoperative values relative to preoperative values. Postoperative overall survival (OS), local progression-free survival (LPFS), and the factors affecting them were evaluated using the Kaplan-Meier method and log-rank test. RESULTS: The 5-year OS and LPFS rates were 39.5% and 65.6%, respectively. The factors affecting OS were sex, Katagiri score, visceral metastases, and preoperative targeted therapy, while the factors affecting LPFS were pathologic fractures and surgical technique. CONCLUSION: In this study, the postoperative outcomes of palliative surgery for bone metastases from metastatic RCC were good. We suggest that systemic treatment should be prioritized over local control for advanced bone metastasis in RCC and surgery before pathological fracture should be performed for local control.

  Nov. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 49(5) (5), 928 - 933, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of Metal Implants on Quantitative Evaluation of Bone Single-Photon Emission Computed Tomography/Computed Tomography.

  Keisuke Oe, Feibi Zeng, Takahiro Niikura, Tomoaki Fukui, Kenichi Sawauchi, Tomoyuki Matsumoto, Munenobu Nogami, Takamichi Murakami, Ryosuke Kuroda

  When visualizing biological activity at nonunion sites by the radioisotopes, gamma rays are more attenuated if metal implants are placed in the bone. However, the effects of various implant types and their placement on gamma ray attenuation in quantitative evaluation remain unknown. To elucidate these effects, we created a phantom that simulated the nonunion of the femur in this study. The count of gamma rays was measured by single-photon emission computed tomography/computed tomography (SPECT/CT) while considering CT-based attenuation correction (CTAC), metal implant placement, type (intramedullary nail or plate), and position. The count differed significantly with and without CTAC and with and without implants (both types) under CTAC. Significantly different counts were observed between the intramedullary nail and plate placed contralaterally to the lesion (i.e., non-lesion side). No significant difference was observed between the intramedullary nail and plate on the lesion side or between plates on the non-lesion and lesion sides. The measured standardized uptake value (SUV) was closer to the true SUV with CTAC than without. Moreover, the count was higher with implants than without. However, even with implants, it was lower than the actual count, indicating the absence of overcorrection. Implant type and position do not seem to influence the count.

  Nov. 2022, Journal of clinical medicine, 11(22) (22), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Identification and characterization of slow‑cycling cells in Ewing sarcoma.

  Shunsuke Yahiro, Teruya Kawamoto, Shuichi Fujiwara, Hitomi Hara, Naomasa Fukase, Ryoko Sawada, Toshiyuki Takemori, Tomohiro Miyamoto, Yutaka Mifune, Kenichiro Kakutani, Yuichi Hoshino, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue

  Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.

  Nov. 2022, International journal of oncology, 61(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment.

  Shinya Hayashi, Tsukasa Matsubara, Toshihisa Maeda, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Ken Tsumiyama, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda

  We compared the efficacy of tocilizumab and etanercept in inhibiting radiographic progression of joint destruction in rheumatoid arthritis. Overall, 187 patients treated with etanercept or tocilizumab were selected. To adjust for baseline patient characteristics between the tocilizumab and etanercept treatment groups, a propensity score matching was performed. Radiographic progression of joint destruction was compared between patients treated with tocilizumab or etanercept. Clinical disease activity index (CDAI) and modified health assessment questionnaire (mHAQ) scores at the administration of biologic treatment and after 12 months of tocilizumab and etanercept therapy were measured and compared to radiographical parameters between the groups. Levels of C-reactive protein (CRP), matrix metalloproteinase-3 (MMP-3), CDAI, and mHAQ scores improved after 12 months of treatment in the two groups. Proportion of patients with no Sharp erosion score progression was significantly higher with tocilizumab treatment than with etanercept treatment (p = 0.032). Multivariate analysis demonstrated that Sharp erosion score was significantly associated with baseline CDAI (odds ratio, 1.05; 95% confidence interval, 1.003-1.099, p = 0.037). Tocilizumab treatment suppressed joint erosion progression compared to etanercept, and the progression correlated with baseline CDAI.

  Oct. 2022, Scientific reports, 12(1) (1), 17524 - 17524, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Development and Analysis of Mouse Medial Meniscus Posterior Root Tear Model

  Koji Nukuto, Takehiko Matsushita, Kohei Kamada, Kyohei Nishida, Kanto Nagai, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Springer Science and Business Media LLC, Oct. 2022, Calcified Tissue International, 112(1) (1), 55 - 65

  Scientific journal


• Polyarthritis presented in a patient with untreated chronic hepatitis B infection

  Kenichi Kikuchi, Koji Fukuda, Shinya Hayashi, Toshihisa Maeda, Yoshinori Takashima, Masahiro Fujita, Kenmei Ikuta, Kensuke Anjiki, Shotaro Tachibana, Yuma Onoi, Tomoyuki Matsumoto, Ryosuke Kuroda, Tsukasa Matsubara

  ABSTRACT Hepatitis B virus (HBV) infection can cause arthritis, but it is rarely reported. In the current report, we present a case of chronic polyarthritis in a patient with untreated HBV infection. A 63-year-old woman suffering from polyarthritis in her fingers visited our institution. She had experienced exacerbations and remissions of polyarthritis for more than 20 years. She had been diagnosed with rheumatoid arthritis and had been treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and nonsteroidal anti-inflammatory drugs by her primary care doctor, but the csDMARDs were discontinued at the request of the patient 10 years before the first visit to our hospital. The blood test showed negative for rheumatoid factor and anticyclic citrullinated peptides antibody but positive for hepatitis B surface antigen. Hepatitis B surface antigen and HBV-Deoxyribo Nucleic Acid (DNA) were increased to 312.6 (IU/ml) and 4.6 (log copies/ml), respectively. Based on the results of abdominal computed tomography and echography, she was diagnosed with liver cirrhosis. Treatment for HBV infection was begun with oral tenofovir at 25 mg/day. The polyarthritis in her fingers gradually disappeared and has not relapsed for 6 months after the initiation of treatment for HBV infection. When polyarthritis is diagnosed, the possibility that chronic HBV infection can be one of the causes of polyarthritis should be considered.

  Oxford University Press (OUP), Oct. 2022, Modern Rheumatology Case Reports, 7(1) (1), 320 - 323

  Scientific journal


• Varus placement of the tibial component of Oxford unicompartmental knee arthroplasty decreases the risk of postoperative tibial fracture.

  Yoshihito Suda, Takafumi Hiranaka, Tomoyuki Kamenaga, Motoki Koide, Takaaki Fujishiro, Koji Okamoto, Tomoyuki Matsumoto

  AIMS: A fracture of the medial tibial plateau is a serious complication of Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). The risk of these fractures is reportedly lower when using components with a longer keel-cortex distance (KCDs). The aim of this study was to examine how slight varus placement of the tibial component might affect the KCDs, and the rate of tibial plateau fracture, in a clinical setting. METHODS: This retrospective study included 255 patients who underwent 305 OUKAs with cementless tibial components. There were 52 males and 203 females. Their mean age was 73.1 years (47 to 91), and the mean follow-up was 1.9 years (1.0 to 2.0). In 217 knees in 187 patients in the conventional group, tibial cuts were made orthogonally to the tibial axis. The varus group included 88 knees in 68 patients, and tibial cuts were made slightly varus using a new osteotomy guide. Anterior and posterior KCDs and the origins of fracture lines were assessed using 3D CT scans one week postoperatively. The KCDs and rate of fracture were compared between the two groups. RESULTS: Medial tibial fractures occurred after surgery in 15 patients (15 OUKAs) in the conventional group, but only one patient (one OUKA) had a tibial fracture after surgery in the varus group. This difference was significant (6.9% vs 1.1%; p = 0.029). The mean posterior KCD was significantly shorter in the conventional group (5.0 mm (SD 1.7)) than in the varus group (6.1 mm (SD 2.1); p = 0.002). CONCLUSION: In OUKA, the distance between the keel and posterior tibial cortex was longer in our patients with slight varus alignment of the tibial component, which seems to decrease the risk of postoperative tibial fracture.Cite this article: Bone Joint J 2022;104-B(10):1118-1125.

  Oct. 2022, The bone & joint journal, 104-B(10) (10), 1118 - 1125, English, International magazine

  Scientific journal


• Effects of Femoral Component Design on the Deepest Point Position of the Trochlear Grove in Kinematically Aligned Total Knee Arthroplasty: A Comparison of Four Prothesis Designs

  Yoshinori Takashima, Naoki Nakano, Kazunari Ishida, Tomoyuki Kamenaga, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Abstract The aim of the study is to explore and compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee matched with preoperative computed tomography (CT). Thirty patients were scheduled for primary kinematically aligned total knee arthroplasty (TKA) for varus knee osteoarthritis at our hospital and the region between their pelvis to ankle joint was simulated using a CT-based three-dimensional planning software. The axial plane containing the transepicondylar axis was set as Slice A, and the 10-mm distal plane from Slice A was set as Slice B. The distances to the deepest trochlear groove between the native knee and each prosthesis and the medial and lateral facet heights were compared among the four groups. The deepest femoral trochlear groove of the prostheses was located 1.6 to 3.0 mm more medial than that of the native knee, and in the Persona group, it was significantly more medial than in the e-motion or Triathlon groups on both Slices A and B. The native knee and the medial and lateral facet heights of the four prostheses on both Slices A and B were significantly lower than those of preoperative native knees when femoral prostheses were set in the kinematically aligned (KA)-TKA position. The deepest point of the trochlear groove of the Persona group was the most medial among the four prostheses studied, and the deepest points differed depending on the prosthesis design in KA-TKA. Thus, surgeons should carefully select the type of prostheses used in KA-TKA.

  Georg Thieme Verlag KG, Sep. 2022, The Journal of Knee Surgery, 36(13) (13), 1316 - 1322

  Scientific journal


• The influence of stem alignment on the bone mineral density around the Polarstem following total hip arthroplasty

  Masahiro Fujita, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Science and Business Media LLC, Sep. 2022, Archives of Orthopaedic and Trauma Surgery, 143(6) (6), 3621 - 3627

  Scientific journal


• Paracrine effect of the stromal vascular fraction containing M2 macrophages on human chondrocytes through the Smad2/3 signaling pathway.

  Masahiro Fujita, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Naoki Nakano, Toshihisa Maeda, Yuichi Kuroda, Yoshinori Takashima, Kenichi Kikuchi, Kensuke Anjiki, Kemmei Ikuta, Yuma Onoi, Shotaro Tachibana, Takehiko Matsushita, Hideki Iwaguro, Satoshi Sobajima, Takafumi Hiranaka, Ryosuke Kuroda

  The adipose-derived stromal vascular fraction (SVF) is composed of a heterogeneous mix of adipose-derived stem cells (ADSCs), macrophages, pericytes, fibroblasts, blood, and other cells. Previous studies have found that the paracrine effects of SVF cells may be therapeutic, but their role in osteoarthritis treatment remains unclear. This study aimed to investigate the therapeutic effect of SVF cells on chondrocytes. Chondrocytes were seeded on culture plates alone (control) or cocultured with SVF or ADSCs on cell culture inserts. After 48 h of coculture, chondrocyte collagen II, tissue inhibitors of metalloproteinases-3 (TIMP-3), and matrix metalloproteinases-13 (MMP-13) messenger RNA (mRNA) expression levels were evaluated using reverse-transcription polymerase chain reaction, and the transforming growth factor-β (TGF-β) levels in the supernatant were measured using ELISA. Immunohistochemical staining and flow cytometry were used to evaluate the macrophages in the SVF. These macrophages were characterized according to phenotype using the F4/80, CD86, and CD163 markers. To determine whether the Smad2/3 signaling pathways were involved, the chondrocytes were pre-treated with a Smad2/3 phosphorylation inhibitor and stimulated with the SVF, and then Smad2/3 phosphorylation levels were analyzed using western blot. The mRNA expression levels of various paracrine factors and chondrocyte pellet size were also assessed. Collagen II and TIMP-3 expression were higher in the SVF group than in the ADSC group and controls, while MMP-13 expression was the highest in the ADSC group and the lowest in the controls. TGF-β levels in the SVF group were also elevated. Immunohistochemical staining and flow cytometry revealed that the macrophages in the SVF were of the anti-inflammatory phenotype. Western blot analysis showed that the SVF increased Smad2/3 phosphorylation, while Smad2/3 inhibitors decreased phosphorylation. Smad2/3 inhibitors also reduced the expression of various other paracrine factors and decreased chondrocyte pellet size. These findings suggested that the paracrine effect of heterogeneous cells, such as anti-inflammatory macrophages, in the SVF partly supports chondrocyte regeneration through TGF-β-induced Smad2/3 phosphorylation.

  Sep. 2022, Journal of cellular physiology, 237(9) (9), 3627 - 3639, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Second-Look Arthroscopic Findings and Clinical Outcomes after Adipose-Derived Regenerative Cell Injection in Knee Osteoarthritis.

  Yuma Onoi, Takafumi Hiranaka, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: To evaluate the clinical outcomes and second-look arthroscopic findings after intra-articular adipose-derived regenerative cell (ADRC) injection as treatment for knee osteoarthritis (OA). METHODS: ADRCs were administered to 11 patients (19 knees; mean age, 61.7 years) with knee OA. Subcutaneous adipose tissue was harvested by liposuction from both thighs, and arthroscopic lavage was performed, followed by ADRC injection (mean dose, 1.40 × 107 cells) into the synovial fluid. Outcome measures included the Knee Injury and Osteoarthritis Outcome Score, Lysholm score, and visual analog scale score. Arthroscopic examinations were performed to assess the International Cartilage Repair Society cartilage injury grade preoperatively and overall repair postoperatively. Noninvasive assessments were performed at baseline and at 1-, 3-, and 6-month follow-ups; arthroscopic assessments were performed at baseline and at 6 months. RESULTS: All outcome measures significantly improved after treatment. This improvement was evident 1 month after treatment and was sustained until the 6-month follow-up. Data from second-look arthroscopy showed better repair in low-grade cartilage lesions than in lesions with a greater degree of damage. No patients demonstrated worsening of Kellgren-Lawrence grade, and none underwent total knee arthroplasty during this period. CONCLUSIONS: Clinical outcomes were improved in patients with knee OA after ADRC administration. Cartilage regeneration was more effective in smaller damaged lesions than in bigger lesions.

  Sep. 2022, Clinics in orthopedic surgery, 14(3) (3), 377 - 385, English, International magazine

  Scientific journal


• The Effect of Prosthesis Type on Intraoperative Soft-Tissue Balance and Clinical Outcomes in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Naoki Nakano, Kazunari Ishida, Yoshinori Takashima, Toshihisa Maeda, Yuichi Kuroda, Shinya Hayashi, Tekehiko Matsushita, Takahiro Niikura, Hirotsugu Muratsu, Ryosuke Kuroda

  Abstract Introduction Kinematically aligned total knee arthroplasty (KA-TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. One of the advantages of KA-TKA is reported to be an easy acquisition of intraoperative soft-tissue balance without excessive medial release for varus osteoarthritis. However, we hypothesized that the prosthesis type affects intraoperative soft-tissue balance even in the KA-TKA. The present study aimed to compare intraoperative soft-tissue balance and clinical outcomes of KA-TKAs using single-radius (SR) or multiradius (MR) prostheses. Materials and Methods Consecutive 70 cruciate-retaining modified KA-TKAs (31 SR and 39 MR) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative soft-tissue balance including joint component gap and varus/valgus balance was measured with femoral component placement and patellofemoral joint reduction throughout the range of motion using offset-type tensor and compared between the two groups. Two years postoperatively, the range of motion and 2011 Knee Society Scores were compared between the two groups. Results and Conclusion Joint component gaps showed no significant differences between the two groups from 0 to 30 degrees of flexion. However, during 60 to 120 degrees of flexion, joint component gaps of SR group showed significantly larger values than those of MR group (p < 0.05). There were no significant differences in varus/valgus balance throughout the range of motion between the two groups. The postoperative clinical outcomes showed no significant differences between the two groups. Interpretation Despite no difference in clinical outcomes, joint component gap showed different patterns due to the prosthesis type in modified KA-TKAs.

  Georg Thieme Verlag KG, Jul. 2022, The Journal of Knee Surgery, 36(10) (10), 1013 - 1019

  Scientific journal


• The influence of ruptured scar pattern of human anterior cruciate ligament remnant tissue on tendon‐bone healing in vivo

  Yoshinori Takashima, Tomoyuki Matsumoto, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Abstract The purpose of this study was to determine whether the transplantation of human cells from a non‐reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon‐bone healing. Human ACL remnant tissue was classified into two groups based on the morphologic pattern as per Crain's classification: (1) non‐reattachment group (Crain Ⅳ) and (2) reattachment group (Crain Ⅰ–Ⅲ). Seventy‐five 10‐week‐old immunodeficient rats underwent ACL reconstruction followed by intracapsular administration of one of the following: (1) ACL‐derived cells from the non‐reattached remnant (non‐reattachment group) (n = 5), (2) ACL‐derived cells from the reattached tissue (reattachment group) (n = 5), or (3) phosphate‐buffered saline (PBS) only (PBS group) (n = 5). Histological (Weeks 2, 4, and 8), immunohistochemical (Week 2), radiographic (Weeks 0, 2, 4, and 8), and biomechanical (Week 8) assessments were performed. Histological evaluation showed high and early healing, induction of endochondral ossification‐like integration, and mature bone ingrowth at Week 4 in the non‐reattachment group. Microcomputed tomography at Week 4 showed that the tibial bone tunnels in the non‐reattachment group were significantly reduced compared to those in the reattachment and PBS groups. Moreover, biomechanical testing showed that ultimate load‐to‐failure in the non‐reattachment group tended to be larger than that in the reattachment group, though not statistically significant. The enhanced healing potential in the non‐reattachment group was explained by the increase in intrinsic angiogenesis/osteogenesis. In the subacute phase, the ACL‐derived cells with the non‐reattached morphologic pattern showed greater and earlier tendon bone healing compared with the cells obtained from the reattached morphologic pattern.

  Wiley, Jun. 2022, Journal of Orthopaedic Research, 41(3) (3), 500 - 510

  Scientific journal


• Analysis of popliteal artery location for high tibial and distal tuberosity osteotomy using contrast-enhanced computed tomography.

  Akiyoshi Mori, Takehiko Matsushita, Nobuaki Miyaji, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Yuichi Hoshino, Ryosuke Kuroda

  BACKGROUND: Our objective was to evaluate the location of popliteal artery (PA) in osteotomy planes during high tibial osteotomy (HTO) and to determine a safer angle for screw drilling to the tibial tuberosity during distal tuberosity osteotomy (DTO). METHODS: Twenty knees in 20 patients who underwent contrast-enhanced computed tomography for cardiovascular diseases were examined. Osteotomy planes for open-wedge HTO (OWHTO) and hybrid closed-wedge HTO (hybrid CWHTO) were created using three-dimensional bone models. The distance from the posterior cortex of the tibia to the PA (dPC-PA) in the osteotomy planes was measured in the virtual osteotomy planes. The dangerous point (Point D1) was defined as the point 17.5 mm away from PA, setting the working length of the bone saw as 35 mm. The distance between the most medial point of the tibial cortex (Point M) and Point D1 in OWHTO and the most lateral point (Point L) and Point D1 in hybrid CWHTO were examined (dM-D1 and dL-D1, respectively). The location of Point D1 to the osteotomy line (%D1) was expressed as percentage, setting the start and end of the osteotomy line as 0% and 100%, respectively. To determine the safe angle for screw drilling in DTO, the angle between the line tangential to the medial cortex of the tibia and that passing through the center of the tibial tuberosity and PA were measured. RESULTS: In OWHTO and hybrid CWHTO, the mean dPC-PA was 10.6 mm (6.9-16.5 mm) and 10.2 mm (7.3-15.4 mm), respectively. The mean dM-D1 in OWHTO was 25.9 mm (24.6-27.2 mm) and dL-D1 in hybrid CWHTO was 5.1 mm (2.9-7.4 mm). The mean %D1 was 47.6 ± 3.7% in OWHTO and 9.3 ± 4.1% in hybrid CWHTO, respectively. The minimal angle between the two lines in DTO was 35.2°. CONCLUSION: PAs could run within 10 mm from the posterior cortex in the osteotomy planes of HTO. Therefore, proper posterior protection is necessary when cutting posterior cortex. An angle of less than 35° against the medial cortex line would be safe for screw fixation to avoid vascular injury in DTO.

  May 2022, Knee surgery & related research, 34(1) (1), 25 - 25, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association Between Meeting Return-to-Sport Criteria and Psychological Readiness to Return to Sport After Anterior Cruciate Ligament Reconstruction.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Rei Ono, Kanto Nagai, Yuichi Hoshino, Tomoyuki Matsumoto, Yoshitada Sakai, Ryosuke Kuroda

  Background: The relationship between meeting return-to-sport criteria and psychological readiness after anterior cruciate ligament (ACL) reconstruction is unknown. Purposes: To examine (1) whether patients who met 1 of the criteria for return to sport had higher psychological readiness than those who did not meet any of the criteria and (2) if those who met more criteria had higher psychological readiness. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study included 144 patients who underwent unilateral ACL reconstruction. All patients had regularly participated in some sport activities before an ACL rupture. At 12 months postoperatively, each patient completed 3 knee function tests (isokinetic quadriceps strength, isokinetic hamstring strength, and single-leg hop distance) and 2 self-reported measures (International Knee Documentation Committee [IKDC] 2000 subjective form and ACL-Return to Sport after Injury [ACL-RSI] scale); the ACL-RSI scale was used to measure psychological readiness to return to sport. The 4 criteria for return to sport were a limb symmetry index (LSI) ≥90% for each of the 3 function tests in addition to an IKDC score ≥90. Multivariate regression analysis was used to determine the association between meeting the individual criteria and the ACL-RSI score. In addition, the patients were divided into 5 groups according to the number of criteria met, and the Kruskal-Wallis and Steel-Dwass tests were used to compare the ACL-RSI scores among the groups. Results: Overall, 23 patients (16.0%) met none of the criteria for return to sport, 27 (18.7%) met 1 of the criteria, 34 (23.6%) met 2 criteria, 35 (24.3%) met 3 criteria, and 25 (17.4%) met all 4 criteria. Meeting the criteria for the hamstring strength LSI (P = .002), single-leg hop distance LSI (P = .004), and IKDC subjective score (P < .001) was each associated with higher ACL-RSI scores. Significant differences in ACL-RSI scores were found between patients who met none versus 2, 3, and 4 of the return-to-sport criteria (P < .001 for all) and between patients who met 1 versus 4 criteria (P < .001). Conclusion: Meeting return-to-sport criteria was positively associated with psychological readiness, and the patients who met multiple criteria had higher psychological readiness.

  May 2022, Orthopaedic journal of sports medicine, 10(5) (5), 23259671221093985 - 23259671221093985, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Successful Conservative Treatment of an Acute Arterial Occlusion After Total Knee Arthroplasty: Report of 2 Cases and Review of the Literature.

  Kemmei Ikuta, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yoshinori Takashima, Hiroki Ohnishi, Shinya Hayashi, Yuichi Kuroda, Ryosuke Kuroda

  BACKGROUND Acute arterial occlusion after total knee arthroplasty (TKA) is a rare but occasionally limb-threatening complication. Successful outcomes of surgical treatment for acute arterial occlusion after TKA have been frequently reported in the literature; however, few reports have described conservative treatment. This case report describes the successful conservative treatment of popliteal artery occlusion after TKA. CASE REPORT We report 2 cases of popliteal artery occlusion after TKA that were managed with conservative treatment. In Case 1, a 68-year-old woman presented with a weak dorsalis pedis pulse in the foot and weakness to dorsiflexion of the toe on the operative side immediately after TKA. The operative lower extremity arterial ultrasonography and computed tomography angiography demonstrated the popliteal artery occlusion. In Case 2, a 79-year-old woman presented a cold right foot and lack of popliteal and dorsalis pedis pulse in the operated extremity immediately after TKA, and Doppler ultrasound did not reveal a flow for the dorsalis pedis artery. In both patients, urgent angiographies showed popliteal artery occlusion, and blood flow was observable in the anterior tibial, peroneal, and foot arteries collateral perfusion. Thus, conservative treatments were chosen, and anticoagulant and vasodilator therapies were undergone in both patients. At 6 months after surgery, they were able to walk without intermittent claudication. CONCLUSIONS Conservative treatment can be a good option for popliteal artery occlusion after TKA in cases of rich collateral circulation.

  Apr. 2022, The American journal of case reports, 23, e936295, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 脂肪組織由来間質血管細胞群の軟骨細胞への作用機序の検討

  藤田 雅広, 松本 知之, 林 申也, 傍島 聰, 平中 崇文, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 143 - 143, Japanese


• Risk factors of residual pivot-shift after anatomic double-bundle anterior cruciate ligament reconstruction.

  Kohei Kamada, Takehiko Matsushita, Kanto Nagai, Yuichi Hoshino, Daisuke Araki, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  INTRODUCTION: Although anterior cruciate ligament reconstruction (ACLR) is considered a successful procedure, residual pivot-shift after surgery remains to be solved. The purpose of this study was to comprehensively evaluate the risk factors of residual pivot-shift after anatomic double-bundle (DB) ACLR. MATERIALS AND METHODS: A total of 164 patients who underwent primary anatomic DB-ACLR between January 2014 and December 2019 and screw removal after the index ACLR in our hospital were included in this retrospective case-control study. The manual pivot-shift test was performed under general anesthesia during screw removal surgery, and patients with grade 1 or higher pivot-shift were classified as the positive pivot-shift group, and those with grade 0 were defined as the negative pivot-shift group. Univariate and logistic regression analyses were performed to identify the factors associated with postoperative residual pivot-shift. Assessment included sex, age, time to surgery, preoperative Tegner activity scale, preoperative pivot-shift grade, preoperative anterior tibial translation by the KT-2000 arthrometer measurement, meniscus injury and its surgical procedure, knee hyperextension, cartilage damage, Segond fracture, medial and lateral posterior tibial slope, lateral-medial slope asymmetry, participation in pivoting sport/activity at the time of injury, and return to sports at postoperative one year line. RESULTS: Postoperative positive pivot-shift was observed in 14 (8.5%) of 164 patients. The KT-2000 measurement at 1-year postoperatively was significantly higher in the residual pivot-shift-positive group than in the negative group (P < 0.05). Logistic regression analysis revealed that age of patients < 20 years [P < 0.05, odds ratio (OR): 6.1)], preoperative pivot-shift grade (P < 0.05, OR: 4.4), and hyperextended knee (P < 0.05, OR: 11.8) were risk factors of postoperative pivot-shift. There were no statistically significant differences between other variables. CONCLUSIONS: Patients < 20 years of age, with high-grade preoperative pivot-shift, or hyperextended knees had a higher risk of residual postoperative pivot-shift.

  Apr. 2022, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A phase I/IIa clinical trial of third-generation autologous chondrocyte implantation (IK-01) for focal cartilage injury of the knee.

  Takehiko Matsushita, Tomoyuki Matsumoto, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Takahiro Niikura, Atsuhiko Kawamoto, Masahiro J Go, Shin Kawamata, Masanori Fukushima, Ryosuke Kuroda

  Background/objective: The purpose of this study was to report the outcomes of a clinical trial conducted in Japan to assess the safety and effectiveness of third-generation autologous chondrocyte implantation (ACI) using IK-01 (CaReS™), which does not require flap coverage, in the treatment of patients with focal cartilage injury of the knee. Methods: This was an open label, exploratory clinical trial. Patients were enrolled between June 2012 and September 2016. The primary endpoint of the study was the International Knee Documentation Committee (IKDC) score at 52 weeks after implantation. The IKDC, Lysholm, and visual analog scale (VAS) scores were evaluated at the time of screening and at 4, 12, 24, 36, and 52 weeks after implantation. Improvements from the baseline scores were evaluated using the equation "(postoperative score) - (preoperative score)." Magnetic resonance imaging (MRI) was performed at 2, 12, 24, and 52 weeks after implantation, and MRI measurements were evaluated using T1 rho and T2 mapping. Results: Nine patients were enrolled in this study and were examined for safety. Product quality did not satisfy the specification in one patient, and bacterial joint infection occurred in one patient. As a result, seven patients were included in the outcome analyses. The mean IKDC score significantly improved from 36.4 preoperatively to 74.1% at 52 weeks after implantation (p < 0.0001). The mean Lysholm and VAS scores also significantly improved from 39.6 to 57.4 to 89.6 and 22.9, respectively, after surgery. In the MRI evaluation, the T1 rho and T2 values of the implanted area were similar to those of the surrounding cartilage at 52 weeks after implantation. Conclusions: Third generation ACI (IK-01) can be an effective treatment option for focal cartilage defects of the knee; however, surgeons must pay careful attention to the risk of postoperative joint infection.

  Apr. 2022, Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology, 28, 6 - 12, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Peri-prosthetic bone remodeling of hydroxyapatite-coated compaction short stem was not affected by stem alignment.

  Shinya Hayashi, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Toshihisa Maeda, Takahiro Niikura, Ryosuke Kuroda

  BACKGROUND: To improve implant survival through accelerated early bone remodeling during total hip arthroplasty (THA), hydroxyapatite (HA) is widely used as a bioactive coating, which is believed to enhance initial fixation by osseointegration. We aimed to investigate the relationship between stem insertion alignment and postoperative bone mineral density (BMD) changes in patients with full hydroxyapatite-coated (HA) compaction short stem and short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 115 consecutive patients (115 joints) undergoing THA using the full HA compaction short (n = 59) and short tapered-wedge (n = 56) stems. Stem alignment, including anteversion, valgus, and anterior tilt were measured by a three-dimensional template using computed tomography data. Post-operative peri-prosthetic BMD was measured by dual-energy X-ray absorptiometry. The relationship between stem alignment and BMD changes in the stems was analyzed. RESULTS: Patterns of peri-prosthetic BMD changes were similar in both groups. Stem insertion alignments of anteversion, valgus, and anterior tilt were different between the two stem types. Stem alignment of valgus and anterior tilt did not affect peri-prosthetic BMD in either of the stem type. An absolute anteversion difference between stem anteversion and original canal anteversion caused significant peri-prosthetic BMD loss in Gruen zones one and seven in the tapered-wedge stem. However, stem alignment of absolute anteversion difference did not affect BMD changes in the HA compaction stem. CONCLUSIONS: Peri-prosthetic bone remodeling remained unaffected by stem alignment after THA with the new short full HA compaction stem.

  Mar. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 131 - 131, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 難治性骨折に対する自家CD34陽性細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• Rectangular taper shortステムとtaper wedge shortステムのTHA術後ステム周囲骨密度変化とステム前捻による影響の比較検討

  安喰 健祐, 林 申也, 藤代 高明, 黒田 雄一, 亀長 智幸, 高島 良典, 中野 直樹, 前田 俊恒, 松本 知之, 平中 崇文, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S233 - S233, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 難治性骨折に対する自家CD34陽節細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• Patients' Characteristics Can Predict Clinical Outcomes Following Hip Arthroscopy by Reflecting the Patterns of Labral Tears: A Retrospective Observational Study.

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Masahiko Haneda, Yuichi Kuroda, Tomoyuki Matsumoto, Ryosuke Kuroda

  PURPOSE: To evaluate the relationship between morphological differences in labral tears and clinical features of the hip joint in patients who underwent hip arthroscopy. MATERIALS AND METHODS: We retrospectively analyzed data from patients who underwent arthroscopic surgery for the treatment of labral tears. Hip labral tears were morphologically classified as longitudinal peripheral tears (group L), radial fibrillated tears (group FI), radial flaps (group FL), and an unstable labrum (group U). Radiographically, the center-edge angle, acetabular roof obliquity, vertical-center-anterior angle, alpha angle, femoral head-neck offset ratio, and crossover sign were evaluated and compared among the groups. The relationship between labral morphology and these radiographic findings, as well as clinical findings, such as age, gender, preoperative range of hip motion, and the clinical outcomes using modified Harris Hip Score (mHHS) were also examined. RESULTS: This study included fifty patients. Groups L and FI were often observed in late middle-aged patients with relatively shallow acetabular coverage. Group FL tears were frequently observed in young males with radiographic features, such as femoroacetabular impingement (FAI), compared to the other groups. Group U comprised mostly young females with relatively shallow acetabular coverage compared to the other groups. For the postoperative mHHS, group FL showed the best score among all groups, with a significant difference between groups FL and FI (p = 0.034). CONCLUSIONS: Our study revealed that morphologically, different labral tears were associated with different clinical features and radiological findings. Especially, our study can provide predictive findings for hip arthroscopists that younger males with FAI show better clinical outcomes when compared to middle-aged females with shallow acetabulum, which is indicative of degenerative hip labral tears. LEVEL OF EVIDENCE: IV case series.

  Feb. 2022, Indian journal of orthopaedics, 56(2) (2), 295 - 302, English, International magazine

  Scientific journal


• Combination of Anterior Acetabular Coverage and Femoral Head Shape Predicts Femoroacetabular Impingement After Periacetabular Osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  BACKGROUND: Femoroacetabular impingement (FAI) after periacetabular osteotomy (PAO) may be affected by both anterior acetabular coverage and femoral head shape. This study aimed to radiographically evaluate the relationship of the combination of acetabular coverage and femoral head shape with the occurrence of FAI after curved PAO. METHODS: In this study, 76 hip joints from patients with symptomatic developmental dysplasia of the hip underwent curved PAO. The relationship between the combined postoperative anterior center-edge and alpha angles (ie, the combination angle) and the occurrence of postoperative FAI was evaluated. Clinical factors and the preoperative and postoperative 3-dimensional center-edge angles, acetabular versions, femoral versions, radiographic alpha angles of the femoral head, and the combination angle were measured and compared to clinical outcomes. RESULTS: The modified Harris Hip Scores, University of California, Los Angeles activity scores, and acetabular coverage angles were significantly improved following curved PAO. Receiver operator characteristic curve analysis demonstrated that the combination angle over 108° may be a predictive factor for the occurrence of FAI after curved PAO. Multivariate analysis demonstrated that an age <40 years (odds ratio 6.6, 95% confidence interval 1.2-36.4, P = .037) and a combination angle <108° (odds ratio 9.2, 95% confidence interval 1.7-50.0, P = .010) were significantly associated with modified Harris Hip Scores ≧90 points. CONCLUSION: A combination angle >108° may be a predictive factor for the occurrence of FAI after curved PAO and impaired clinical outcomes. To avoid postoperative FAI, we propose that osteochondroplasty of the femoral head should be performed for patients with preoperative combination angles >90°.

  Feb. 2022, The Journal of arthroplasty, 37(2) (2), 219 - 225, English, International magazine

  Scientific journal


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Feb. 2022, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Robotic arm-assisted posterior-stabilized total knee arthroplasty reduces the amount of tibial bone resection thickness without increasing the rate of postoperative flexion contracture in varus knees in the short term: Comparison with image-free navigated total knee arthroplasty.

  Kazunari Ishida, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: This study aimed to compare the bone resection thickness, rate of minimal thickness insert usage, and postoperative range of motion (ROM) between robotic and navigated TKA. METHODS: Fifty consecutive posterior-stabilized (PS) robotic TKA and 50 case-controlled PS navigated TKA were enrolled. Bone resection thickness, rate of minimal thickness insert usage, and postoperative flexion contracture over 5X00B0; were statistically compared. RESULTS: The tibial bone resection thickness was significantly thinner in robotic TKA. The insert thickness was significantly lower, and the rate of minimal thickness insert usage was significantly higher in robotic TKA. The ROM at 3 months postoperatively and the rate of postoperative flexion contracture were comparable between the two groups. CONCLUSION: Robotic TKA can reduce the tibial bone resection thickness and increase the rate of minimal thickness insert usage without increasing postoperative flexion contracture as compared with navigated TKA. This article is protected by copyright. All rights reserved.

  Jan. 2022, The international journal of medical robotics + computer assisted surgery : MRCAS, 18(3) (3), e2370, English, International magazine

  Scientific journal


• Fully hydroxyapatite-coated compaction broached and triple-tapered stem may reduce the risk of stress shielding after primary total hip arthroplasty.

  Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Changes in bone mineral density (BMD) around the fully hydroxyapatite (HA)-coated compaction broached and triple-tapered stem, namely, Polarstem, after total hip arthroplasty (THA) are currently unknown. Therefore, the aims of this study were to investigate clinical outcomes of Polarstem, mainly postoperative temporal changes in BMD around the stem for 2 years, and to compare them with those of HA-coated and non-HA-coated tapered-wedge stems. METHODS: This retrospective cohort study enrolled 100 consecutive patients who underwent THA using Polarstem (n = 38), HA-coated Anthology (n = 31), and non-HA-coated Anthology (n = 31). BMD was evaluated using dual-energy X-ray absorptiometry in seven regions according to the Gruen zones. Postoperatively, BMD around the stem was assessed within 2 months (baseline BMD) and at 6, 12, and 24 months. A change in BMD was defined as the value calculated by dividing each postoperative BMD value at 6, 12, and 24 months by the baseline BMD value. Changes in BMD and radiographic parameters such as stress shielding and spot welds were compared among the three stems. RESULTS: The incidence rate of stress shielding in the Polarstem group was significantly lower than those in the other two groups (p = 0.007). The change in BMD in Zone 7 of Polarstem was significantly more than that of the other two groups at 12 and 24 months postoperatively (p = 0.030 and p = 0.009, respectively). CONCLUSION: Polarstem, a fully HA-coated compaction broached and triple-tapered stem, maintained BMD around the femoral calcar until 2 years postoperatively and could reduce the risk of stress shielding compared with tapered-wedge stems.

  Jan. 2022, Archives of orthopaedic and trauma surgery, 142(12) (12), 4087 - 4093, English, International magazine

  Scientific journal


• Anterior acetabular coverage and femoral head-neck measurements predict postoperative anterior impingement: A simulation study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Ryosuke Kuroda

  The aim of this simulation study was to evaluate the relationship of elements of anterior acetabular coverage and femoral head-neck shape with the occurrence of postoperative anterior impingement after curved periacetabular osteotomy (PAO). Sixty-two patients with symptomatic developmental dysplasia of the hip who had undergone curved PAO were selected. The likelihood of developing postoperative anterior impingement was explored through simulations of the range of motion by collision detection of the pelvis and femur. Postoperative anterior impingement was defined as impingement that occurred during postoperative bone flexion <105° or postoperative internal rotation <20° at 90° flexion. The three-dimensional center-edge (CE) angles, acetabular and femoral versions, radiographic alpha angles of the femoral head, combination angles of anterior CE and alpha angles, and combined anteversions of acetabular and femoral versions were compared between patients with postoperative anterior impingement and nonimpingement. A receiver operator characteristic (ROC) analysis was conducted to determine thresholds of the examined radiographic parameters and calculate their accuracy for predicting postoperative anterior impingement. A multivariate analysis was performed to test whether combined anteversion, anterior CE angle, and combination angle are associated with excellent modified Harris Hip Scores (mHHSs). ROC analysis demonstrated a combination angle ≥108° was predictive of the occurrence of postoperative anterior impingement after curved PAO, which can lead to impaired clinical outcomes. Conversely, a combination angle <108° was significantly associated with mHHS ≥ 90 points. To avoid postoperative anterior impingement, osteochondroplasty of the femoral head or anterior CE angle control should be performed for patients with preoperative combination angles ≥90°.

  Jan. 2022, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, English, International magazine

  Scientific journal


• Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

  Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A genome-wide association study identifying single nucleotide polymorphisms in the PPFIBP2 gene was predictive for interstitial lung disease in rheumatoid arthritis patients.

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Toshihisa Maeda, Keiko Funahashi, Marowa Hashimoto, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Tomoyuki Matsumoto, Ryosuke Kuroda

  OBJECTIVE: Genetic polymorphisms might serve as useful prognostic markers for the timely diagnosis of RA. The purpose of this study was to identify genomic factors predictive of the occurrence of interstitial lung disease (ILD) in RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). METHODS: The study population included 306 RA patients. All patients were treated with conventional DMARDs, including 6-16 mg MTX per week. Clinical data and venous blood samples were collected from all patients before administration of DMARDs. A total of 278 347 SNPs were analysed to determine their association with ILD occurrence. RESULTS: Several SNPs were strongly associated with ILD occurrence (P < 10-5). rs6578890, which is located on chromosome 11 in the intronic region of the gene encoding tyrosine phosphatase receptor type F polypeptide-interacting protein-binding protein 2 (PPFIBP2), showed the strongest association with ILD occurrence (odds ratio 4.32, P = 10-7.93). CONCLUSION: PPFIBP2 could be a useful genetic marker for occurrence of interstitial pneumonia in RA patients and might help to identify the risk of ILD occurrence before RA treatment, thereby improving patient outcomes.

  2022, Rheumatology advances in practice, 6(3) (3), rkac088, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical Outcomes and Prognostic Factors in Soft Tissue Sarcoma Patients After Unplanned Excision.

  Toshiyuki Takemori, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Purpose: Soft tissue sarcomas (STSs) constitute a group of rare, heterogeneous tumors representing approximately 1% of all cancers. Owing to the rarity and pathological diversity of the disease, unplanned excision (UE) has often been performed for STS, resulting in an unfavorable prognosis. This study aimed to clarify clinical outcomes and prognostic factors in STS patients who underwent UE. Patients and Methods: In a retrospective review of the medical records of patients with STS who underwent surgery at our institution between 1999 and 2015, patients were enrolled to either a UE group or a planned excision (PE) group. An analysis was then conducted to identify factors associated with prognosis after UE. Results: Of 134 patients undergoing surgery for STS, 110 were enrolled to the PE group and 24 to the UE group. The median size of the primary tumor was significantly smaller, and more lesions were located in the superficial layer in the UE group than in the PE group. In addition, plastic reconstruction after additional radical resection was required significantly more often in the UE group than in the PE group. No significant difference in overall survival, local recurrence-free survival, or disease-free survival (DFS) between the UE and PE groups was observed; however, metastasis-free survival was significantly better in the UE group. In the UE group, poorer DFS was associated with older age (≥61 years) and a larger primary tumor (≥2.9 cm). Conclusion: A prognosis similar to that in patients undergoing PE could be achieved by appropriate additional surgeries in patients initially undergoing UE. However, UE for STS should be avoided, especially in older patients and those with a larger primary tumor.

  2022, Cancer management and research, 14, 1815 - 1824, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 前期高齢者に対する人工膝関節全置換術、術後3年の移動歩行能力の予測

  加藤 達雄, 村津 裕嗣, 井口 貴雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 115 - 116, Japanese


• PS-TKAにおける術後1年の移動歩行能力を悪化させる外側弛緩性閾値の検討

  井口 貴雄, 村津 裕嗣, 加藤 達雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 215 - 216, Japanese


• PS-TKA術後の膝過伸展を減らすのに有用な術中軟部組織バランスの指標

  西田 亮太, 村津 裕嗣, 井口 貴雄, 加藤 達雄, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 217 - 218, Japanese


• 後期高齢者に対する人工膝関節全置換術、術後3年の移動歩行能力の予測

  加藤 達雄, 村津 裕嗣, 井口 貴雄, 西田 亮太, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 229 - 230, Japanese


• 術後早期の膝安定性がPS-TKA術後3年の患者満足度に及ぼす影響

  西田 亮太, 村津 裕嗣, 井口 貴雄, 加藤 達雄, 宮島 明博, 前田 琢磨, 古賀 敬章, 圓尾 明弘, 宮 秀俊, 松本 知之, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2021, 日本人工関節学会誌, 51, 667 - 668, Japanese


• Satisfaction with playing pre-injury sports 1 year after anterior cruciate ligament reconstruction using a hamstring autograft.

  Yuya Ueda, Takehiko Matsushita, Yohei Shibata, Kohei Takiguchi, Kumiko Ono, Akihiro Kida, Rei Ono, Kanto Nagai, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Yoshitada Sakai, Ryosuke Kuroda

  BACKGROUND: Few studies have examined patient satisfaction with playing pre-injury sports after anterior cruciate ligament (ACL) reconstruction. The purpose of this study was to investigate patient satisfaction with playing pre-injury sport and identify factors associated with satisfaction. METHODS: A total of 97 patients underwent unilateral ACL reconstruction using a hamstring autograft and returned to pre-injury sports 1 year after surgery. Patient satisfaction with playing pre-injury sport was assessed by a visual analog scale (VAS) and an ordinal four-grade scale. Problems related to the operated knee were also assessed. Knee muscle strength, single leg hop distance, knee laxity, subjective knee pain, and fear of movement/reinjury using Tampa Scale for Kinesiophobia-11 (TSK-11) were measured. Multivariate linear regression analysis was performed to determine the factors associated with patient satisfaction with playing pre-injury sport 1 year after surgery. RESULTS: The average VAS score for patient satisfaction with playing pre-injury sports 1 year after surgery was 77.8 ± 20.2. Of the 97 patients, 87 patients (89.7%) answered "satisfied" or "mostly satisfied", whereas 51 patients (52.6%) had one or more problems. Multivariate linear regression analysis identified that the TSK-11 score was associated with patient satisfaction with playing a pre-injury sport 1 year after surgery. CONCLUSION: Most of the patients who returned to pre-injury sports were satisfied with their outcomes. In contrast, approximately half of the patients had one or more problems after returning to play pre-injury sports. In particular, fear of movement/reinjury was significantly associated with patient satisfaction with playing pre-injury sport 1 year after surgery.

  Dec. 2021, The Knee, 33, 282 - 289, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model

  Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Dec. 2021, Stem Cell Research and Therapy, 12(1) (1), 110 - 110, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Early postoperative clinical recovery of robotic arm-assisted vs. image-based navigated Total hip Arthroplasty

  Nao Shibanuma, Kazunari Ishida, Tomoyuki Matsumoto, Koji Takayama, Yutaro Sanada, Masahiro Kurosaka, Ryosuke Kuroda, Shinya Hayashi

  Dec. 2021, BMC Musculoskeletal Disorders, 22(1) (1), 314 - 314, English, International magazine

  Scientific journal


• Regulatory roles of miRNAs 16, 133a, and 223 on osteoclastic bone destruction caused by breast cancer metastasis.

  Kazumichi Kitayama, Teruya Kawamoto, Yohei Kawakami, Hitomi Hara, Toshiyuki Takemori, Shuichi Fujiwara, Shunsuke Yahiro, Tomohiro Miyamoto, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Osteolytic bone metastasis leads to skeletal‑related events, resulting in a decline in the patient activities and survival; therefore, it is important to understand the mechanism underlying bone metastasis. Recent studies have suggested that microRNAs (miRNAs or miRs) are involved in osteoclast differentiation and/or osteolytic bone metastasis; however, the roles of miRNAs have not been elucidated. In the present study, the roles of miRNAs in bone destruction caused by breast cancer metastasis were investigated in vitro and in vivo. miR‑16, miR‑133a and miR‑223 were transfected into a human breast cancer cell line, MDA‑MB‑231. The expression of osteolytic factors in conditioned medium (miR‑CM) collected from the culture of transfected cells was assessed. To evaluate the effects of miRNAs on osteoclast differentiation and activities, tartrate‑resistant acid phosphatase (TRAP) staining and bone resorptive assays were performed in osteoclasts following miR‑CM treatment. To create in vivo bone metastasis models for histological and morphometric evaluation, miRNA‑transfected MDA‑MB‑231 cells were transplanted into the proximal tibia of nude mice. Expression of osteolytic factors, including receptor activator for nuclear factor‑κB ligand (RANKL), interleukin (IL)‑1β, IL‑6, parathyroid hormone‑related protein (PTHrP), and tumor necrosis factor (TNF), was increased in miR‑16‑CM, whereas it was decreased in both miR‑133a‑CM and miR‑223‑CM. TRAP staining and bone resorptive assays revealed that osteoclast function and activities were promoted by miR‑16‑CM treatment, whereas they were suppressed by miR‑133a‑CM and miR‑223‑CM. Consistent with in vitro findings, in vivo experiments revealed that the overexpression of miR‑16 increased osteoclast activities and bone destruction in MDA‑MB‑231 cells, whereas the opposite results were observed in both miR‑133a‑ and miR‑223‑transfected MDA‑MB‑231 cells. Our results indicated that miR‑16 promoted osteoclast activities and bone destruction caused by breast cancer metastasis in the bone microenvironment, whereas miR‑133a and miR‑223 suppressed them. These miRNAs could be potential biomarkers and therapeutic targets for breast cancer bone metastasis.

  Nov. 2021, International journal of oncology, 59(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative varus deformity of the knee affects the intraoperative joint gap in unicompartmental knee arthroplasty.

  Naoki Nakano, Koji Takayama, Yuichi Kuroda, Toshihisa Maeda, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: It is generally believed that contraction of the soft tissue structures on the medial side may occur in the knee with severe varus deformity. However, the relationship between the severity of varus deformity of the knee and the intraoperative soft tissue balance in unicompartmental knee arthroplasty (UKA) has not been well reported thus far. METHODS: One hundred and three consecutive medial UKAs were enrolled. After the femoral trial prosthesis was placed, the component gap was measured at 10° (extension) and 120° (flexion) of flexion using a UKA tensor. The pre-osteotomy gap was then calculated from the thickness of the bone cut. Paired Student's t-test was used to compare the component gap, as well as the pre-osteotomy gap, in extension and those in flexion. The relationship between the preoperative Hip-Knee-Ankle (HKA) angle and the pre-osteotomy gap was analysed using Pearson's correlation coefficient and simple linear regression analysis. RESULTS: The component gap in extension was significantly smaller than that in flexion while the pre-osteotomy gap in extension was significantly wider than that in flexion. There was a positive correlation between the severity of varus deformation in preoperative knee and the pre-osteotomy gap in extension, while there was no correlation between the preoperative HKA angle and the pre-osteotomy gap in flexion. CONCLUSIONS: The tension of the medial tightness does not correlate with the degree of preoperative varus deformity in UKA.

  Oct. 2021, The Knee, 32, 90 - 96, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Robotic-arm assisted THA can achieve precise cup positioning in developmental dysplasia of the hip : a case control study.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Ryosuke Kuroda

  AIMS: This study aimed to evaluate the accuracy of implant placement with robotic-arm assisted total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). METHODS: The study analyzed a consecutive series of 69 patients who underwent robotic-arm assisted THA between September 2018 and December 2019. Of these, 30 patients had DDH and were classified according to the Crowe type. Acetabular component alignment and 3D positions were measured using pre- and postoperative CT data. The absolute differences of cup alignment and 3D position were compared between DDH and non-DDH patients. Moreover, these differences were analyzed in relation to the severity of DDH. The discrepancy of leg length and combined offset compared with contralateral hip were measured. RESULTS: The mean values of absolute differences (postoperative CT-preoperative plan) were 1.7° (standard deviation (SD) 2.0) (inclination) and 2.5° (SD 2.1°) (anteversion) in DDH patients, and no significant differences were found between non-DDH and DDH patients. The mean absolute differences for 3D cup position were 1.1 mm (SD 1.0) (coronal plane) and 1.2 mm (SD 2.1) (axial plane) in DDH patients, and no significant differences were found between two groups. No significant difference was found either in cup alignment between postoperative CT and navigation record after cup screws or in the severity of DDH. Excellent restoration of leg length and combined offset were achieved in both groups. CONCLUSION: We demonstrated that robotic-assisted THA may achieve precise cup positioning in DDH patients, and may be useful in those with severe DDH. Cite this article: Bone Joint Res 2021;10(10):629-638.

  Oct. 2021, Bone & joint research, 10(10) (10), 629 - 638, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Attenuation of Knee Osteoarthritis Progression in Mice through Polarization of M2 Macrophages by Intra-Articular Transplantation of Non-Cultured Human Adipose-Derived Regenerative Cells.

  Kohei Kamada, Takehiko Matsushita, Takahiro Yamashita, Tomoyuki Matsumoto, Hideki Iwaguro, Satoshi Sobajima, Ryosuke Kuroda

  Adipose-derived regenerative cells (ADRCs) are non-cultured heterogeneous or mixed populations of cells obtained from adipose tissue by collagenase digestion. The injection of ADRCs have been tried clinically for the treatment of osteoarthritis (OA). The purpose of this study was to evaluate the effect of intra-articular transplantation of human ADRCs on OA progression in mice and the effect of ADRCs on macrophage polarization. In in vivo experiments, BALB/c-nu mice with knee OA received intra-articular transplantation of either phosphate buffered-saline or human ADRCs. OA progression was evaluated histologically and significantly attenuated in the ADRC group at both four and eight weeks postoperatively. The expression of OA-related proteins in the cartilage and macrophage-associated markers in the synovium were examined by immunohistochemistry. The numbers of MMP-13-, ADAMTS-5-, IL-1β-, IL-6- and iNOS-positive cells significantly decreased, and type II collagen- and CD206-positive cells were more frequently detected in the ADRC group compared with that in the control group. In vitro co-culture experiments showed that ADRCs induced macrophage polarization toward M2. The results of this study suggest that the intra-articular transplantation of human ADRCs could attenuate OA progression possibly by reducing catabolic factors in chondrocytes and modulating macrophage polarization.

  Sep. 2021, Journal of clinical medicine, 10(19) (19), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Lateral osteoarthritis progression is associated with a postoperative residual tibiofemoral subluxation in Oxford UKA.

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yuichi Hida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  PURPOSE: Lateral compartment osteoarthritis progression (LOP) is a major complication after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to identify the association between tibiofemoral subluxation (TFS) and LOP after OUKA. Patients whose TFS was uncorrectable according to preoperative stress radiographs were hypothesised to develop residual TFS even after surgery, and thought to be more likely to develop LOP. METHODS: The study included 201 patients who underwent medial OUKA. Fifteen patients showed increases in LOP of at least two Kellgren-Lawrence grades after surgery [progression (P) group], while the others had no progression (N group, n = 186). TFS was measured on preoperative full leg weight-bearing radiographs, valgus stress radiographs and postoperative plain radiographs. Valgus stress radiographs were obtained using a firm manual valgus force with the knee flexed at 20°. Leg alignment, Oxford knee score (OKS), and revision rates were assessed. RESULTS: The P group had significantly higher TFS values on preoperative valgus stress (6.8° ± 2.2° vs. 4.5° ± 2.0°; P < 0.001) and postoperative radiographs (6.6° ± 2.3° vs. 4.6° ± 2.9°; P < 0.001) than the N group. Patients with postoperative residual TFS and postoperative valgus alignment were more likely to have LOP, but 9 of the 15 LOP patients did not show postoperative valgus alignment. The P group had significantly poorer postoperative OKS (33.0 ± 10.2 vs. 37.4 ± 6.5, P = 0.017) and a higher rate of revision (6/15 vs 6/186; odds ratio = 19.16; 95% CI = 4.98-76.05, P < 0.001). CONCLUSION: OA progression in the lateral compartment after medial OUKA might be associated with postoperative residual TFS, but does not always coexist with postoperative valgus alignment. Preoperative assessment of TFS with valgus stress could be a potential predictor of postoperative residual TFS and LOP. LEVEL OF EVIDENCE: Level III.

  Sep. 2021, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(9) (9), 3236 - 3243, English, International magazine

  Scientific journal


• Preoperative uncorrectable tibiofemoral subluxation can worsen clinical outcomes after fixed-bearing unicompartmental knee arthroplasty: a retrospective analysis.

  Tomoyuki Kamenaga, Naoki Nakano, Kazunari Ishida, Masanori Tsubosaka, Yuichi Kuroda, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  INTRODUCTION: The presence of tibiofemoral subluxation (TFS) in patients with unicompartmental arthritis, a potential contraindication to unicompartmental knee arthroplasty (UKA), remains controversial and is not commonly discussed. This study aimed to determine the predictability of postoperative TFS before surgery and the effect of TFS on clinical outcomes after fixed-bearing UKA. MATERIALS AND METHODS: In total, 70 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA from January 2015 to January 2017 were included. The preoperative TFS was assessed using plain anteroposterior and valgus stress radiographs. The patients were classified into three groups as follows: group A (acceptable TFS, n = 36) comprising patients with preoperative TFS less than 5.0 mm; group C (correctable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm but corrected to less than 5.0 mm under valgus stress; and group U (uncorrectable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm under valgus stress. Patient-derived clinical scores were assessed with the 2011 Knee Society Score preoperatively and 2 years postoperatively. The results were compared among the three groups using analysis of variance. RESULTS: Group U showed significantly higher postoperative TFS than groups A and C. Improvements in "symptoms" and "patient satisfaction" scores 2 years after surgery were significantly higher in groups A and C than in group U. CONCLUSION: Preoperative assessment of TFS under valgus stress could be a predictor of postoperative TFS. Furthermore, preoperative uncorrectable TFS could increase pain and decrease patient satisfaction 2 years after undergoing fixed-bearing UKA.

  Sep. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects.

  Sep. 2021, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis.

  Koji Fukuda, Yasushi Miura, Toshihisa Maeda, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda

  Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissues leads to the formation of pannus that invades the joint cartilage and bone, resulting in joint destruction. Fas ligand (FasL), which is a member of the tumor necrosis factor superfamily, contributes to the pathogenesis of autoimmune diseases, including RA. The current study attempted to identify genes whose expressions in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by FasL, using cDNA microarray. A total of four individual lines of primary cultured RA-FLS were incubated either with recombinant human FasL protein or PBS as an unstimulated control for 12 h. Gene expression was detected using a microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by Fas and investigated the functions of the genes that were regulated. Among the genes in this profile, the mRNA expression changes of the following genes were indicated to be of note using RT-qPCR: Dual specificity phosphatase 6, epiregulin, interleukin 11, angiopoietin-like 7, protein inhibitor of activated STAT 2 and growth differentiation factor 5. These genes may affect the pathogenesis of RA by affecting apoptosis, proliferation, cytokine production, cytokine-induced inflammation, intracellular signaling, angiogenesis, bone destruction and chondrogenesis. To the best of our knowledge, the current study is the first study to reveal the expression profile of genes in RA-FLS regulated by FasL. The data demonstrated that FasL may regulate the expression of a number of key molecules in RA-FLS, thus affecting RA pathogenesis. Further studies of the genes detected may improve the understanding of RA pathogenesis and provide novel treatment targets for RA.

  Sep. 2021, Experimental and therapeutic medicine, 22(3) (3), 1000 - 1000, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Outcomes of total knee replacement with the use of a NexGen MIS Tibial Component (Mini-keel) : a systematic review.

  Naoki Nakano, Kiyonori Mizuno, Koji Takayama, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  NexGen MIS Tibial Component (Mini-keel) is a tibial component specially developed for minimally invasive surgery in total knee replacement (TKR), and the size limitations of its design and the modular system could affect tibial fixation strength, however, this has not been precisely evaluated thus far. This study aimed to systematically review the literature describing the outcome following TKR with the use of a Mini-keel. Electronic searches of databases were undertaken in July 2019 by two experienced orthopaedic surgeons according to the PRISMA guidelines for literature describing the outcomes of TKR with the use of a Mini-keel. Quality of studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. The initial search found a total of 623 studies from all the databases. Seven studies met all the inclusion criteria and were eligible for critical appraisal and quality assessment. In total, 2,198 cases were included in the systematic review. Thirty-five revision cases due to aseptic loosening were found from the systematic review. Two studies were negative about using a Mini-keel and three studies were positive about it, while the other two studies did not judge the quality of a Mini-keel. There have been conflicting conclusions among studies for the use of a Mini-keel. There remains a paucity of prospective cohort studies between TKRs with the use of a Mini-keel and those with the use of a conventional implant, which makes it difficult to determine the usefulness and reliability of this implant.

  Sep. 2021, Acta orthopaedica Belgica, 87(3) (3), 469 - 478, English, International magazine

  Scientific journal


• Hydroxyapatite-coated compaction short stem represents a characteristic pattern of peri-prosthetic bone remodelling after total hip arthroplasty.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  PURPOSE: We aimed to investigate the differences in peri-prosthetic bone remodelling between the full hydroxyapatite (HA)-collared compaction short stem and the short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 159 consecutive patients (159 joints) undergoing total hip arthroplasty (THA) using the full HA compaction short (n = 64) and short tapered-wedge (n = 95) stems. Body mass index (BMI), peri-prosthetic bone mineral density (BMD), and clinical factors, including the Japanese Orthopaedic Association score and the University of California Los Angeles (UCLA) activity score were assessed and compared. RESULTS: Stem related complications were seen in three cases. Both groups showed similar peri-prosthetic BMD changes. Peri-prosthetic BMD was almost maintained in the distal femur and Gruen zone 6 with both type of stems, but significant BMD loss was found in zones 1 and 7 in both groups and in zone 2 of the full HA compaction stem group. No significant correlations were found between the proximal femoral BMD changes and the age, BMI, and UCLA score in both the full HA compaction and tapered-wedge stem groups. Femoral bone shape affected the peri-prosthetic BMD changes in the tapered-wedge stem group but not in the full HA compaction group. The stem collar of the full HA compaction stem did not affect peri-prosthetic BMD, but unique bone remodelling in the calcar region was observed in 27.6% cases. A significant difference in the peri-prosthetic BMD changes at Gruen zone 2 was found in patients with or without thigh pain. CONCLUSION: Peri-prosthetic bone remodelling remained unaffected by clinical and radiographic factors after THA with the new short full HA compaction stem. Therefore, this new stem may be useful in a variety of cases.

  Aug. 2021, Archives of orthopaedic and trauma surgery, English, International magazine

  Scientific journal


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 人工知能モデルによる関節リウマチへの生物学的製剤治療効果の予測

  前田 俊恒, 林 申也, 乾 淳幸, 黒田 雄一, 中野 直樹, 西本 華子, 橋本 慎吾, 美舩 泰, 松本 知之, 松原 司, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1732 - S1732, Japanese


• Knee Flexion Angle Following Total Knee Arthroplasty Relates to a Preoperative Range of Motion of the Hip

  Naoki Nakano, Seiji Kubo, Yutaka Sato, Koji Takayama, Kiyonori Mizuno, Ryosuke Kuroda, Tomoyuki Matsumoto

  Aug. 2021, Indian Journal of Orthopaedics, 55(4) (4), 948 - 952

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Total ankle arthroplasty with total talar prosthesis for talar osteonecrosis with ankle osteoarthritis: A case report

  Nobuaki Chinzei, Noriyuki Kanzaki, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Yuichi Hoshino, Shingo Hashimoto, Koji Takayama, Daisuke Araki, Ryosuke Kuroda

  Jul. 2021, Journal of Orthopaedic Science, 26(4) (4), 725 - 730, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation.

  Yoshinori Takashima, Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Naoki Nakano, Tomoyuki Matsumoto, Ryosuke Kuroda

  We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21-/-) (n = 16) and wild type C57BL/6 (p21+/+) mice (n = 16) served as in vivo models of collagen antibody-induced arthritis (CAIA). Arthritis severity was evaluated by immunological and histological analyses. The response of p21 small-interfering RNA (siRNA)-treated human RA FLSs (n = 5 per group) to interleukin (IL)-1β stimulation was determined in vitro. Arthritis scores were higher in p21-/- mice than in p21+/+ mice. More severe synovitis, earlier loss of Safranin-O staining, and cartilage destruction were observed in p21-/- mice compared to p21+/+ mice. p21-/- mice expressed higher levels of IL-1β, TNF-α, F4/80, CD86, p-IKKα/β, and matrix metalloproteinases (MMPs) in cartilage and synovial tissues via IL-1β-induced NF-kB signaling. IL-1β stimulation significantly increased IL-6, IL-8, and MMP expression, and enhanced IKKα/β and IκBα phosphorylation in human FLSs. p21-deficient CAIA mice are susceptible to RA phenotype alterations, including joint cartilage destruction and severe synovitis. Therefore, p21 may have a regulatory role in inflammatory cytokine production including IL-1β, IL-6, and TNF-α.

  Jun. 2021, Scientific reports, 11(1) (1), 12516 - 12516, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Modern femoral component design in total knee arthroplasty shows a lower patellar contact force during knee flexion compared with its predecessor

  Naoki Nakano, Yuichi Kuroda, Toshihisa Maeda, Koji Takayama, Shingo Hashimoto, Kazunari Ishida, Shinya Hayashi, Yuichi Hoshino, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jun. 2021, Knee, 30, 1 - 8, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• External rotation of the tibial component should be avoided in lateral unicompartmental knee arthroplasty

  Masahiro Fujita, Takafumi Hiranaka, Brang Mai, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jun. 2021, Knee, 30, 70 - 77, English, International magazine

  Scientific journal


• Comparison of clinical and biomechanical outcomes between the kinematic and mechanical alignment methods in total knee arthroplasty: Protocol for a multicenter randomized controlled trial

  Yoshinori Takashima, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Shinya Hayashi, Shingo Hashimoto, Toshihisa Maeda, Takao Inokuchi, Mitsunori Toda, Takaaki Chin, Ryosuke Kuroda

  Jun. 2021, Contemporary Clinical Trials Communications, 22, 100775 - 100775, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of plantar pressure distribution during walking and lower limb alignment between modified kinematically and mechanically aligned total knee arthroplasty

  Tomoyuki Kamenaga, Naoki Nakano, Koji Takayama, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Yuichi Kuroda, Shingo Hashimoto, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  May 2021, Journal of Biomechanics, 120, 110379 - 110379, English, International magazine

  Scientific journal


• Clinical experience of the use of reamer irrigator aspirator in Japanese patients: A report of the first 42 cases

  Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  May 2021, Journal of Orthopaedic Science, 26(3) (3), 459 - 465, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Obesity is associated with less favorable outcomes following hip arthroscopic surgery: a systematic review and meta-analysis

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Shinya Hayashi, Naoki Nakano, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  May 2021, Knee Surgery, Sports Traumatology, Arthroscopy, 29(5) (5), 1483 - 1493, English, International magazine


• Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.

  Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.

  Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Accuracy of cup position following robot-assisted total hip arthroplasty may be associated with surgical approach and pelvic tilt.

  Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nao Shibanuma, Tomoyuki Kamenaga, Ryosuke Kuroda

  This study aimed to investigate the accuracy of cup placement and determine the predictive risk factors for inaccurate cup positioning in robot-assisted total hip arthroplasty (THA). We retrospectively analyzed 115 patients who underwent robot-assisted THA between August 2018 and November 2019. Acetabular cup alignment and three-dimensional (3D) position were measured using pre- or postoperative computed tomography (CT) data. Absolute differences in cup inclination, anteversion, and 3D position were assessed, and their relation to preoperative factors was evaluated. The average measurement of the absolute differences was 1.8° ± 2.0° (inclination) and 1.9° ± 2.3° (anteversion). The average absolute difference in the 3D cup position was 1.1 ± 1.2 mm (coronal plane) and 0.9 ± 1.0 mm (axial plane). Multivariate analysis revealed that a posterior pelvic tilt [odds ratio (OR, 1.1; 95% confidence interval (CI), 1.00-1.23] and anterior surgical approach (OR, 5.1; 95% CI, 1.69-15.38) were predictive factors for inaccurate cup positioning with robot-assisted THA. This is the first study to demonstrate the predictive risk factors (posterior pelvic tilt and anterior surgical approach) for inaccurate cup position in robot-assisted THA.

  Apr. 2021, Scientific reports, 11(1) (1), 7578 - 7578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases).

  Hitomi Hara, Yoshitada Sakai, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Kenichiro Kakutani, Takahiro Niikura, Daisuke Miyawaki, Takuya Okada, Akihiro Sakashita, Yoshinori Imamura, Ryohei Sasaki, Yoshiyuki Kizawa, Hironobu Minami, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Toshihiro Akisue

  Background: Skeletal related events due to metastatic bone tumors markedly affect the activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on multidisciplinary therapy for metastatic bone tumors. This study aimed to evaluate the outcomes of surgical treatment for metastatic bone tumors in the extremities. Methods: We retrospectively reviewed 114 patients who underwent surgical treatment for metastatic bone tumors of the extremities between 2008 and 2019 and 69 patients were reassessed for more than 6 months after surgery. The most common primary tumor was renal, followed by lung, thyroid, and breast cancers. We assessed 69 patients' performance status (PS), Barthel Index (BI) for ADL, EuroQol 5 Dimensions (EQ-5D) for QOL, and numerical rating scale (NRS) for pain and analyzed these postoperative values relative to preoperative values using Friedman's test. The postoperative overall survival and the prognostic factors were evaluated using the Kaplan-Meier method, the log-rank test and Cox proportional hazards analysis. Results: The 1-year overall survival rate was 59%, and the median survival time after surgery was 20 months. Primary tumor, visceral metastasis, and surgical procedure were risk factors correlated with overall survival. PS, BI, EQ-5D, and NRS improved at 3 months after surgery and these improvements were maintained for 6 months after surgery regardless of the surgical procedure. Conclusions: The significant factors affecting survival after surgical treatment for bone metastases included the primary tumor, presence of visceral metastases, and internal fixation without tumor resection or curettage. Surgical treatment for metastatic bone tumors effectively reduced pain and improved PS, ADL, and QOL postoperatively after 3 months.

  Apr. 2021, Journal of bone oncology, 27, 100352 - 100352, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【骨折に対する積極的保存療法 基礎編】難治性骨折に対する再生医療 自家末梢血CD34陽性細胞移植

  黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章, 美舩 泰, 松本 知之

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• PS-TKAにおける術中の外側弛緩性が術後移動歩行能力改善に及ぼす影響

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井口 貴雄, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 126 - 127, Japanese

  Link to Kobe Univ. Repository (Kernel)


• Gap balancing techniqueを用いた人工膝関節置換術における大腿骨後顆骨切り精度の検討

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井口 貴雄, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2021, JOSKAS, 46(1) (1), 136 - 137, Japanese

  Link to Kobe Univ. Repository (Kernel)


• BNCT for primary synovial sarcoma.

  Takuya Fujimoto, Minoru Suzuki, Shigeyuki Kuratsu, Ikuo Fujita, Masayuki Morishita, Tamotsu Sudo, Toshiko Sakuma, Yuta Nakamatsu, Yoshinori Sakurai, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Shin-Ichiro Masunaga, Yuko Kinashi, Natsuko Kondo, Shunsuke Sakakibara, Hiroshi Igaki, Tooru Andoh, Setsu Sakamoto, Teruya Kawamoto, Tadashi Watabe, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Tomoyuki Matsumoto, Toshihiro Akisue, Koji Ono, Hideki Ichikawa, Ryosuke Kuroda, Takanori Hirose

  Synovial sarcoma is a rare tumor requiring new treatment methods. A 46-year-old woman with primary monophasic synovial sarcoma in the left thigh involving the sciatic nerve, declining surgery because of potential dysfunction of the affected limbs, received two courses of BNCT. The tumor thus reduced was completely resected with no subsequent recurrence. The patient is now able to walk unassisted, and no local recurrence has been observed, demonstrating the applicability of BNCT as adjuvant therapy for synovial sarcoma. Further study and analysis with more experience accumulation are needed to confirm the real impact of BNCT efficacy for its application to synovial sarcoma.

  Mar. 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 169, 109407 - 109407, English, International magazine

  Scientific journal


• Differences in preoperative planning for high-tibial osteotomy between the standing and supine positions.

  Takehiko Matsushita, Shu Watanabe, Daisuke Araki, Kanto Nagai, Yuichi Hoshino, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  INTRODUCTION: Previous studies have reported that alignment changes depend on the patient's position in orthopedic surgery. However, it has not yet been well examined how the patient's position affects the preoperative planning in high-tibial osteotomy (HTO). Therefore, the aim of this study was to investigate the effects of the patient's position on preoperative planning in HTO. MATERIALS AND METHODS: A total of 60 knees in 55 patients who underwent HTO were retrospectively examined. Virtual preoperative planning for medial open-wedge HTO (OWHTO), lateral closed-wedge HTO (CWHTO), and hybrid CWHTO were performed by setting the percentage of the weight-bearing line (%WBL) at 62% as an optimal alignment. The correction angle differences between the supine and standing radiographs were measured. The virtual %WBL (v%WBL) was determined by applying the correction angle obtained from the standing radiograph to the supine radiograph. The %WBL discrepancy (%WBLd) was calculated as v%WBL - 62 (%) to predict the possible correction errors during surgeries. A single regression analysis was performed to examine the correlation between the correction angle difference and %WBLd. RESULTS: The mean correction angle was significantly higher when the preoperative planning was based on standing radiographs than when based on supine radiographs (P < 0.001), and the mean difference was 2.2 ± 1.5°. The difference between the two conditions in the medial opening gaps for OWHTO, lateral wedge sizes (mm) for CWHTO, and hybrid CWHTO were 2.6 ± 2.0, 2.3 ± 1.6, and 1.9 ± 1.4, respectively. The mean v%WBL was 71.2% ± 7.3%, and the mean %WBLd was 10.1% ± 7.4%. A single regression analysis revealed a linear correlation between the correction angle difference and %WBLd (%WBLd = 4.72 × correction angle difference + 0.08). No statistically significant difference in the parameters was found between the supine and standing radiographs postoperatively. CONCLUSIONS: We found significant differences in the estimated correction angles between the supine and standing radiographs in the planning for HTO. Therefore, surgeons should carefully consider the difference between supine and standing radiographs and estimate the possible correction error during surgery when planning a HTO.

  Mar. 2021, Knee surgery & related research, 33(1) (1), 8 - 8, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of selected plane on the evaluation of tibial tunnel locations using a three-dimensional bone model in double-bundle anterior cruciate ligament reconstruction

  Tetsuya Yamamoto, Kanto Nagai, Daisuke Araki, Nobuaki Miyaji, Yuta Nakanishi, Yuichi Hoshino, Noriyuki Kanzaki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda, Takehiko Matsushita

  Mar. 2021, Knee, 29, 298 - 304, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion.

  Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

  Feb. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 患者まで届いている再生医療 難治性骨折患者への自家末梢血CD34陽性細胞移植

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (株)メディカルレビュー社, Feb. 2021, 再生医療, 20(1) (1), 50 - 55, Japanese


• Mid-flexion stability in the anteroposterior plane is achieved with a medial congruent insert in cruciate-retaining total knee arthroplasty for varus osteoarthritis

  Masanori Tsubosaka, Kazunari Ishida, Kazuki Kodato, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Feb. 2021, Knee Surgery, Sports Traumatology, Arthroscopy, 29(2) (2), 467 - 473, English, International magazine

  Scientific journal


• The sagittal cutting plane affects evaluation of the femoral bone tunnel position on three-dimensional computed tomography after anterior cruciate ligament reconstruction

  Nobuaki Miyaji, Daisuke Araki, Yuichi Hoshino, Noriyuki Kanzaki, Kanto Nagai, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda, Takehiko Matsushita

  Feb. 2021, Knee Surgery, Sports Traumatology, Arthroscopy, 29(2) (2), 398 - 404, English, International magazine

  Scientific journal


• A Cell-free Biodegradable Synthetic Artificial Ligament for the Reconstruction of Anterior Cruciate Ligament in a Rat Model

  Yohei Kawakami, Kazuhiro Nonaka, Naomasa Fukase, Antonio D’ Amore, Yoichi Murata, Patrick Quinn, Samuel Luketich, Koji Takayama, Kunj G. Patel, Tomoyuki Matsumoto, James H. Cummins, Masahiro Kurosaka, Ryosuke Kuroda, William R. Wagner, Freddie H. Fu, Johnny Huard

  Feb. 2021, Acta Biomaterialia, 121, 275 - 287, English, International magazine

  Scientific journal


• Clinical Outcome of the Patients With Brain Metastasis from Soft Tissue Sarcomas.

  Toshiyuki Takemori, Teruya Kawamoto, Masayuki Morishita, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Takuya Fujimoto, Ikuo Fujita, Yutaka Mifune, Yuichi Hoshino, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  BACKGROUND/AIM: This study aimed to evaluate the association of clinical characteristics with treatment outcomes to ascertain the appropriate treatment options for soft tissue sarcomas (STS) patients with brain metastasis (BM). PATIENTS AND METHODS: Medical records of STS patients with BM who were treated in our institutions were retrospectively reviewed, and analyzed to identify the factors associated with post-BM survival. RESULTS: Among the 509 STS patients, BM occurred in five patients (0.98%). The median survival after BM was 1.5 months. Histological subtypes of the primary lesions in the five BM patients were: two synovial sarcomas, one myxoid liposarcoma, one alveolar soft part sarcoma, and one rhabdomyosarcoma. Among the five BM patients, the post-BM survival of two patients, who underwent surgery and postoperative radiotherapy, was longer than that of the other patients (p<0.01). CONCLUSION: Combined surgery and postoperative radiotherapy effectively managed symptoms and prolonged survival in STS patients with BM.

  Feb. 2021, Anticancer research, 41(2) (2), 1027 - 1034, English, International magazine

  Scientific journal


• Debate 変形性膝関節症 UKA vs. TKA

  松本 知之, 松田 秀一

  (株)医学書院, Jan. 2021, 臨床整形外科, 56(1) (1), 97 - 102, Japanese


• Comparison between Single- And Multi-Radius Prostheses Used in Modified Kinematically Aligned Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Yoshinori Takashima, Koji Takayama, Kazunari Ishida, Naoki Nakano, Yuichi Kuroda, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Shinya Hayashi, Ryosuke Kuroda

  2021, Journal of Knee Surgery, English, International magazine

  Scientific journal


• Impact of joint line orientation on clinical outcomes in bilateral Oxford mobile-bearing unicompartmental knee arthroplasty.

  Ryota Nishida, Takafumi Hiranaka, Tomoyuki Kamenaga, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  BACKGROUND: Joint line orientation angle (JLOA) is the angle between the knee joint line and the floor. It has been reported to be related to postoperative outcome after TKA. Regarding unicompartmental knee arthroplasty (UKA), although it can be horizontal after UKA because it is a resurfacing surgery, there are few reports about the JLOA after UKA and its impact on clinical outcomes. PURPOSE: The purpose of this study was to reveal the relationship between JLOA and clinical outcome after UKA. METHODS: This study included 106 knees in 53 consecutive patients with osteoarthritis who underwent simultaneous bilateral mobile-bearing UKA. Their pre- and postoperative JLOAs were measured by full-leg-length standing coronal radiographs. We also evaluated the tibial component height (TCH) as the factor which we assumed could influence JLOA. We analyzed the patients' JLOAs, TCHs and clinical outcomes. RESULTS: Pre- and postoperative JLOA were 0.4 ± 2.4° and 2.7 ± 2.6°, respectively. The JLOA significantly tilted medially (P < 0.0001). The JLOA significantly negatively correlated with the improvement of the clinical outcomes (Oxford Knee Score (OKS): r = 0.40, P < 0.0001, Knee Society Knee Score (KSKS): r = 0.25, P < 0.01, Knee Society Function Score (KSFS): r = 0.22, P = 0.02). The TCH showed a positive correlation with postoperative JLOA and with the postoperative JLOA change (r = 0.45, P < 0.001; r = 0.25, P < 0.01, respectively). CONCLUSION: The JLOA significantly tilted medially after UKA. An excessive medial tilt of the JLOA was associated with poorer postoperative outcomes of UKA. It is therefore recommended to keep the JLOA horizontal and to avoid a lower tibial cut.

  Jan. 2021, The Knee, 28, 186 - 193, English, International magazine

  Scientific journal


• Short distance from the keel to the posterior tibial cortex is associated with fracture after cementless Oxford UKA in Asian patients

  Tomoyuki Kamenaga, Takafumi Hiranaka, Naoki Nakano, Shinya Hayashi, Takaaki Fujishiro, Koji Okamoto, Ryosuke Kuroda, Tomoyuki Matsumoto

  2021, Knee Surgery, Sports Traumatology, Arthroscopy, English, International magazine

  Scientific journal


• Evaluation of consistency of patient-satisfaction score in the 2011 Knee Society Score to other patient-reported outcome measures

  Shotaro Tachibana, Hirotsugu Muratsu, Masanori Tsubosaka, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  2021, Journal of Orthopaedic Science, English, Domestic magazine

  Scientific journal


• Femoro-Epiphyseal Acetabular Roof (FEAR) Index and Anterior Acetabular Coverage Correlate With Labral Length in Developmental Dysplasia of the Hip

  Yuichi Kuroda, Shingo Hashimoto, Masayoshi Saito, Tomoyuki Matsumoto, Naoki Nakano, Ryosuke Kuroda, Shinya Hayashi

  2021, Arthroscopy - Journal of Arthroscopic and Related Surgery, English, International magazine

  Scientific journal


• Knee Stability following Posterior-Stabilized Total Knee Arthroplasty: Comparison of Medial Preserving Gap Technique and Measured Resection Technique

  Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Takao Inokuchi, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  2021, Journal of Knee Surgery, English, International magazine

  Scientific journal


• Transcutaneous CO 2 application accelerates fracture repair in streptozotocin-induced type i diabetic rats

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda

  Dec. 2020, BMJ Open Diabetes Research and Care, 8(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高齢者に対するPS-TKA術後1年の患者満足度と他の患者立脚型評価との相関

  玉岡 拓也, 村津 裕嗣, 栖田 慶仁, 井上 悠, 大月 悠平, 井口 貴雄, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2020, 日本人工関節学会誌, 50, 11 - 12, Japanese


• CR-TKAにおける術後下肢前額面アライメントが術後膝関節安定性に及ぼす影響

  栖田 慶仁, 村津 裕嗣, 玉岡 拓也, 井上 悠, 大月 悠平, 井口 貴雄, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2020, 日本人工関節学会誌, 50, 211 - 212, Japanese


• Risk factors of thigh pain following total hip arthroplasty with short, tapered-wedge stem

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda

  Dec. 2020, International Orthopaedics, 44(12) (12), 2553 - 2558, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Extent of in vivo sagittal bearing movement and its relationship with tibial posterior slopes in Oxford mobile-bearing unicompartmental knee arthroplasty

  Tomoyuki Kamenaga, Yuichi Hida, Takafumi Hiranaka, Toshikazu Tanaka, Kenjiro Okimura, Masanori Tsubosaka, Yuchi Kuroda, Naoki Nakano, Shinya Hayashi, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Dec. 2020, Clinical Biomechanics, 80, 105148 - 105148, English, International magazine

  Scientific journal


• Boron neutron capture therapy for clear cell sarcoma

  Takuya Fujimoto, Minoru Suzuki, Tamotsu Sudo, Ikuo Fujita, Toshiko Sakuma, Yoshinori Sakurai, Takanori Hirose, Masayuki Morishita, Takushi Takata, Yuki Tamari, Hiroki Tanaka, Tooru Andoh, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yohei Kawakami, Rika Shigemoto, Tomoyuki Matsumoto, Hideki Ichikawa, Koji Ono, Ryosuke Kuroda, Toshihiro Akisue

  Dec. 2020, Applied Radiation and Isotopes, 166, 109324 - 109324, English, International magazine

  Scientific journal


• Predictive factors for effective selection of Interleukin-6 inhibitor and tumor necrosis factor inhibitor in the treatment of rheumatoid arthritis

  Shinya Hayashi, Tsukasa Matsubara, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Toshihisa Maeda, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Dec. 2020, Scientific Reports, 10(1) (1), 16645 - 16645, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Central Implantation of the Femoral Component Relative to the Tibial Insert Improves Clinical Outcomes in Fixed-Bearing Unicompartmental Knee Arthroplasty

  Tomoyuki Kamenaga, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2020, Journal of Arthroplasty, 35(11) (11), 3108 - 3116, English, International magazine

  Scientific journal


• Acquisition of cancer stem cell properties in osteosarcoma cells by defined factors

  Shuichi Fujiwara, Teruya Kawamoto, Yohei Kawakami, Yasufumi Koterazawa, Hitomi Hara, Toshiyuki Takemori, Kazumichi Kitayama, Shunsuke Yahiro, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Michiyo Koyanagi-Aoi, Takashi Aoi, Ryosuke Kuroda, Toshihiro Akisue

  Oct. 2020, Stem Cell Research and Therapy, 11(1) (1), 429 - 429, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Varus deformity in the proximal tibia and immediate postoperative varus alignment result in varus progression in limb alignment in the long term after total knee arthroplasty

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2020, Knee Surgery, Sports Traumatology, Arthroscopy, 28(10) (10), 3287 - 3293, English, International magazine

  Scientific journal


• Why are patients dissatisfied following a total knee replacement? A systematic review

  Naoki Nakano, Haitham Shoman, Fernando Olavarria, Tomoyuki Matsumoto, Ryosuke Kuroda, Vikas Khanduja

  Oct. 2020, International Orthopaedics, 44(10) (10), 1971 - 2007, English, International magazine

  Scientific journal


• Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model

  Masanori Tsubosaka, Shinsuke Kihara, Shinya Hayashi, Junpei Nagata, Toshie Kuwahara, Masahiro Fujita, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Tomoyuki Matsumoto, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda

  Oct. 2020, Journal of Orthopaedic Research, 38(10) (10), 2157 - 2169, English, International magazine

  [Refereed]

  Scientific journal


• Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting total knee arthroplasty

  Takao Inokuchi, Kazunari Ishida, Koji Takayama, Nao Shibanuma, Shinya Hayashi, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sep. 2020, Knee Surgery, Sports Traumatology, Arthroscopy, 28(9) (9), 2816 - 2822, English, International magazine

  [Refereed]

  Scientific journal


• Improved implant alignment accuracy with an accelerometer-based portable navigation system in medial unicompartmental knee arthroplasty

  Yoshihito Suda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sep. 2020, Knee Surgery, Sports Traumatology, Arthroscopy, 28(9) (9), 2917 - 2923, English, International magazine

  [Refereed]

  Scientific journal


• Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair

  Takahiro Oda, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Takahiro Niikura

  Sep. 2020, Journal of Orthopaedic Science, 25(5) (5), 886 - 891, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• マウスにおける非培養ヒト脂肪組織由来再生細胞の移植による変形性膝関節症の進行の抑制

  山下 貴大, 松下 雄彦, 松本 知之, 岩畔 英樹, 傍島 聰, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1962 - S1962, Japanese


• 下肢難治性骨折に対する細胞治療

  黒田 良祐, 新倉 隆宏, 福井 友章, 大江 啓介, 松本 知之

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S36 - S36, Japanese


• Larger Acetabular Labrum Is Associated With Hip Dysplasia, Joint Incongruence, and Clinical Symptoms

  Tomoyuki Kamenaga, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sep. 2020, Arthroscopy - Journal of Arthroscopic and Related Surgery, 36(9) (9), 2446 - 2453, English, International magazine

  Scientific journal


• Preoperative anterior coverage of the medial acetabulum can predict postoperative anterior coverage and range of motion after periacetabular osteotomy: A cohort study

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  Aug. 2020, Journal of Orthopaedic Surgery and Research, 15(1) (1), 312 - 312, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Percutaneous CO2Treatment Accelerates Bone Generation during Distraction Osteogenesis in Rabbits

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935

  Scientific journal


• Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.

  Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazine

  Scientific journal


• Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Makoto Kunisada, Nozomi Yamano, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Chikako Nishigori, Ryosuke Kuroda

  Aug. 2020, PLoS ONE, 15(8 August) (8 August), e0235948, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Overcorrection of the acetabular roof angle or anterior center-edge angle may cause decrease of range of motion after curved periacetabular osteotomy.

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Tomoyuki Kamenaga, Takahiro Niikura, Ryosuke Kuroda

  The aim of this study was to evaluate the relationship between the correction of radiographic parameters and clinical range of motion (ROM) after periacetabular osteotomy (PAO). Sixty-nine patients with hip dysplasia were enrolled and underwent curved PAO. The pre- and post-operative 3D center-edge (CE) angles, total anteversion (acetabular and femoral anteversion), and radiographic acetabular roof angle were measured and compared with the post-operative ROM. The aim of surgery was to rotate the central acetabular fragment laterally without anterior or posterior rotation. Multiple linear regression analysis demonstrated that post-operative internal rotation at 90° flexion was significantly associated with the post-operative Tönnis sourcil angle (rr = 0.31, P = 0.02) and that the post-operative ROM of flexion and internal rotation at 90° flexion were significantly associated with the anterior CE (flex; rr = -0.44, P = 0.001, internal rotation at 90° flexion; rr = -0.44, P < 0.001). However, we found no association between the lateral CE, femoral anteversion, or total anteversion and the post-operative ROM. We demonstrated that the overcorrection of the acetabular roof angle or anterior CE angle may cause a decrease in the range of motion after curved PAO. Therefore, surgeons need to be careful during surgery to prevent the overcorrection of the weight-bearing area and anterior acetabular coverage of the acetabular fragment to avoid femoroacetabular impingement after PAO.

  Aug. 2020, Journal of hip preservation surgery, 7(3) (3), 583 - 590, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma

  Teruya Kawamoto, Hitomi Hara, Masayuki Morishita, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Shunsuke Yahiro, Tomohiro Miyamoto, Takuya Fujimoto, Ikuo Fujita, Kenichiro Kakutani, Tomoyuki Matsumoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Toshihiro Akisue

  Aug. 2020, Clinical and Experimental Metastasis, 37(4) (4), 509 - 517, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Greater knee joint laxity remains in teenagers after anatomical double-bundle anterior cruciate ligament reconstruction compared to young adults

  Yuta Nakanishi, Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Aug. 2020, Knee Surgery, Sports Traumatology, Arthroscopy, 28(8) (8), 2663 - 2667, English, International magazine

  [Refereed]

  Scientific journal


• Evaluation of the accuracy of acetabular cup orientation using the accelerometer-based portable navigation system

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Tomoyuki Kamenaga, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda

  Jul. 2020, Journal of Orthopaedic Science, 25(4) (4), 612 - 617, English, Domestic magazine

  [Refereed]

  Scientific journal


• Predictors of Health-Related Quality of Life After Revision Total Hip Arthroplasty for Aseptic Loosening

  Yuichi Kuroda, Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Ryosuke Kuroda

  Jul. 2020, Indian Journal of Orthopaedics, 54(4) (4), 463 - 468, English, International magazine

  Scientific journal


• Comparison of intraoperative soft tissue balance measurement between two tensor systems in total knee arthroplasty

  Yoshinori Takashima, Koji Takayama, Kazunari Ishida, Hirotsugu Muratsu, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jun. 2020, Knee, 27(3) (3), 1071 - 1077, English, International magazine

  Scientific journal


• Mobile-bearing insert reduced patellar contact force at knee flexion during posterior stabilized total knee arthroplasty

  Yuichi Kuroda, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jun. 2020, Clinical Biomechanics, 76, 105022 - 105022, English, International magazine

  Scientific journal


• Prediction of intra-articular pathology and arthroscopic outcomes for femoroacetabular impingement and labral tear based on the response to preoperative anaesthetic hip joint injections

  Nobuaki Chinzei, Shingo Hashimoto, Shinya Hayashi, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda

  May 2020, European Journal of Orthopaedic Surgery and Traumatology, 30(4) (4), 737 - 742, English, International magazine

  Scientific journal


• The Influences of Chronicity and Meniscal Injuries on Pivot Shift in Anterior Cruciate Ligament–Deficient Knees: Quantitative Evaluation Using an Electromagnetic Measurement System

  Kyohei Nishida, Takehiko Matsushita, Yuichi Hoshino, Daisuke Araki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  May 2020, Arthroscopy - Journal of Arthroscopic and Related Surgery, 36(5) (5), 1398 - 1406, English, International magazine

  [Refereed]

  Scientific journal


• 左坐骨結節裂離骨折の変形治癒後に坐骨神経障害を生じた1例

  井上 亜美, 橋本 慎吾, 高山 孝治, 黒田 雄一, 壺坂 正徳, 亀長 智幸, 高島 良典, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 344 - 345, Japanese

  Link to Kobe Univ. Repository (Kernel)


• TKA術後患者におけるKnee Society Score 2011患者満足度とその他の評価方法との比較

  立花 章太郎, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 362 - 363, Japanese

  Link to Kobe Univ. Repository (Kernel)


• Medial preserving gap techniqueを用いたCR-TKAとPS-TKAの術後膝関節安定性の比較検討

  生田 健明, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 立花 章太郎, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 366 - 367, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 術前の開眼片脚立位バランス能力は、TKA術後の介護支援の予測に有用である

  立花 章太郎, 村津 裕嗣, 荒木 祥太郎, 平中 良明, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 476 - 477, Japanese

  Link to Kobe Univ. Repository (Kernel)


• 単顆型人工膝関節置換術において術後の脛骨後方傾斜角が立位伸展角および最大伸展角に及ぼす影響

  平中 良明, 村津 裕嗣, 荒木 祥太郎, 立花 章太郎, 生田 健明, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2020, JOSKAS, 45(2) (2), 480 - 481, Japanese

  Link to Kobe Univ. Repository (Kernel)


• The influence of adipose-derived stromal vascular fraction cells on the treatment of knee osteoarthritis

  Masanori Tsubosaka, Tomoyuki Matsumoto, Satoshi Sobajima, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

  Apr. 2020, BMC Musculoskeletal Disorders, 21(1) (1), 207 - 207, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Altered microRNA profile during fracture healing in rats with diabetes

  Shunsuke Takahara, Sang Yang Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Michio Arakura, Yoshitada Sakai, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  Apr. 2020, Journal of Orthopaedic Surgery and Research, 15(1) (1), 135 - 135, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 整形外科専門医研修プログラムの抱える問題点 神戸大学整形外科専門研修プログラムの現状と課題

  松本 知之, 美舩 泰, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S644 - S644, Japanese


• 健側膝における脛骨後方傾斜角が立位膝側面アライメントに及ぼす影響 前十字靱帯損傷症例と半月損傷症例の比較

  平中 良明, 村津 裕嗣, 荒木 祥太郎, 立花 章太郎, 生田 健明, 大島 隆司, 松本 知之, 松下 雄彦, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2020, JOSKAS, 45(1) (1), 68 - 69, Japanese


• Influence of Narrow Femoral Implants on Intraoperative Soft Tissue Balance in Posterior-Stabilized Total Knee Arthroplasty

  Kazunari Ishida, Nao Shibanuma, Hiroshi Sasaki, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Feb. 2020, Journal of Arthroplasty, 35(2) (2), 388 - 393, English, International magazine

  [Refereed]

  Scientific journal


• Sequential changes in lower extremity function after total knee arthroplasty

  Masanori Tsubosaka, Hirotsugu Muratsu, Naoki Nakano, Tomoyuki Kamenaga, Yuichi Kuroda, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  2020, Journal of Orthopaedic Surgery, 28(3) (3)

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomy

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Nao Shibanuma, Kazunari Ishida, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda

  2020, HIP International, 1120700020910370 - 1120700020910370, English, International magazine

  Scientific journal


• Recovery of activity level following total hip arthroplasty in patients less than 60 years of age

  Kazuhiro Takeuchi, Shingo Hashimoto, Tomoyuki Matsumoto, Shinya Hayashi, Koji Takayama, Ryosuke Kuroda

  2020, HIP International, 1120700020911911 - 1120700020911911, English, International magazine

  Scientific journal


• Sciatic Nerve Palsy following Curved Periacetabular Osteotomy.

  Masahiro Fujita, Shinya Hayashi, Kenichi Kikuchi, Yoshinori Takashima, Tomoyuki Kamenaga, Masanori Tsubosaka, Koji Fukuda, Koji Takayama, Shingo Hashimoto, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve palsy has been reported. In this study, we describe a case of postoperative sciatic nerve palsy following CPO due to nerve strangulation by scar tissue without direct injury. A female patient had severe buttock pain and posterior leg numbness after she underwent left-side CPO. Postoperative magnetic resonance imaging showed that the sciatic nerve was strangulated by the surrounding soft tissue. There was no bone fragment, active infection, bone necrosis, tumor, or spine disease. Therefore, we diagnosed nerve palsy by soft tissue strangulation, and revision surgery was indicated. During revision surgery, the sciatic nerve was observed to be strangulated by the scarring soft tissue, and the nerve had no mobility. After detachment, the pain and numbness disappeared. Direct injury of the sciatic nerve should not be caused by CPO; however, there is a possibility of postoperative sciatic nerve palsy due to the scarring soft tissue. Early diagnosis and appropriate treatment are important for optimal postoperative clinical outcomes.

  2020, Case reports in orthopedics, 2020, 8569285 - 8569285, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Infected Gustilo IIIB open knee joint fracture treated with an antimicrobial iodine-supported megaprosthesis: A case report

  Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura

  2020, Journal of Orthopaedic Science, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preoperative Condition of the Patellofemoral Joint Does Not Negatively Impact Surgical Outcomes of Lateral Unicompartmental Knee Arthroplasty in the Short Term

  Masahiro Fujita, Takafumi Hiranaka, Tomoyuki Kamenaga, Masanori Tsubosaka, Naoki Nakano, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  2020, Journal of Knee Surgery, English, International magazine

  Scientific journal


• Effectiveness of an accelerometer-based portable navigation for intraoperative adjustment of leg length discrepancy in total hip arthroplasty in the supine position

  Kensuke Anjiki, Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Naoki Nakano, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  2020, Journal of Orthopaedic Science, English, Domestic magazine

  Scientific journal


• Accelerometer-Based Portable Navigation System Is Useful for Tibial Bone Cutting in Modified Kinematically Aligned Total Knee Arthroplasty.

  Masanori Tsubosaka, Tomoyuki Kamenaga, Yuichi Kuroda, Koji Takayama, Shingo Hashimoto, Kazunati Ishida, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Several studies have reported better clinical outcomes following kinematically aligned total knee arthroplasty (KA-TKA) than mechanically aligned TKA. Consistent reproduction of a KA-TKA is aided by accurate tibial bone resections using computer navigation systems. This study compares an accelerometer-based portable navigation system with a conventional navigation system on tibial bone resection and clinical outcomes in KA-TKA. This study included 60 knees of patients who underwent primary KA-TKA between May 2015 and September 2017. They were randomly assigned to the OrthoPilot and iASSIST groups. A tibial bone cut was performed with 3 degree varus and 7 degree posterior slope in relation to the mechanical axis in all cases. The tibial component angle (TCA) and posterior slope angle (PSA) were evaluated by postoperative radiography, and those that deviated more than 2 degree were set as outliers. The clinical outcomes were the knee range of motion (ROM) and 2011 Knee Society Score (KSS) evaluated at 1 year postoperation. The groups were compared in terms of the TCA, PSA, number of outliers, ROM, and 2011 KSS (p < 0.05). No significant difference was observed between the groups in terms of the mean TCA, PSA, number of outliers, ROM, and categories of the 2011 KSS (objective knee indicators, symptoms, satisfaction, expectations, and functional activities). Although tibial bone cuts were performed with 3 degree varus and 7 degree posterior slope, no significant difference was observed between the OrthoPilot and iASSIST groups in terms of the accuracy of cuts or postoperative clinical result. The iASSIST was found to be a simple and useful navigation system for KA-TKA.

  Dec. 2019, The journal of knee surgery, 34(8) (8), 870 - 876, English, International magazine

  Scientific journal


• Radiographic Comparison of the Mechanical Axis Including Calcaneus to the Conventional Mechanical Axis in Medial Unicompartmental Knee Arthroplasty.

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Tomoyuki Kamenaga, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Since a hindfoot alignment is not included in the conventional mechanical axis (hip-ankle [HA] line), a mechanical axis including the calcaneus (hip-calcaneus [HC] line) has recently attracted attention as an alternative weight-bearing line. However, there are few reports on unicompartmental knee arthroplasty (UKA) regarding the HC line. Therefore, this study aimed to compare postoperative alignments after UKA between the HA line and the HC line. Postoperatively, HC radiographs were taken in 88 consecutive patients who underwent medial UKA. The hip-knee-ankle (HKA) and hip-knee-calcaneus (HKC) angles were compared in the same patient. Regarding tibial inclination, the conventional tibial component-ankle (TCA) angle was compared with reference to the HC line (tibial component-calcaneus [TCC] angle). The mean postoperative HKA and HKC angles were 2.8 ± 2.7 and 2.0 ± 2.5 degree, respectively. The mean postoperative TCA and TCC angles were 87.7 ± 2.1 and 88.5 ± 2.1 degree, respectively. There were significant differences between the two groups in both lower limb alignment and tibial component angle. The present study indicated that the HKC and the TCC angles significantly decreased the varus alignment by approximately 1 degree compared with the HKA and TCA angles. Neutral in the HA line corresponds to valgus in reference to the HC line, which may result in overcorrection. Surgeons should consider evaluating the HC line in place of the HA line, which may affect preoperative planning and postoperative outcome during UKA. This is a Level II, diagnostic study.

  Dec. 2019, The journal of knee surgery, 34(9) (9), 930 - 935, English, International magazine

  Scientific journal


• Ras associated with diabetes may play a role in fracture nonunion development in rats

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  Dec. 2019, BMC Musculoskeletal Disorders, 20(1) (1), 602 - 602, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Valgus Subsidence of the Tibial Component Caused by Tibial Component Malpositioning in Cementless Oxford Mobile-Bearing Unicompartmental Knee Arthroplasty

  Tomoyuki Kamenaga, Takafumi Hiranaka, Yuta Nakanishi, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Dec. 2019, Journal of Arthroplasty, 34(12) (12), 3054 - 3060, English, International magazine

  [Refereed]

  Scientific journal


• PS-TKAにおける術中軟部組織バランスが術後1年の移動歩行能力に及ぼした影響

  生田 健明, 村津 裕嗣, 立花 章太郎, 平中 良明, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 55 - 56, Japanese


• 患者年齢はTKA術後満足度の関連因子に影響を及ぼす

  立花 章太郎, 村津 裕嗣, 生田 健明, 大島 隆司, 松本 知之, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 449 - 450, Japanese


• 人工膝関節全置換術の術後下肢機能回復に及ぼす手術時年齢の影響

  生田 健明, 村津 裕嗣, 立花 章太郎, 平中 良明, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2019, 日本人工関節学会誌, 49, 657 - 658, Japanese


• Therapeutic potential of vascular stem cells for anterior cruciate ligament reconstruction.

  Tomoyuki Matsumoto, Koji Takayama, Shinya Hayashi, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda

  Dec. 2019, Annals of translational medicine, 7(Suppl 8) (Suppl 8), S286, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: Results of phase i clinical safety trial

  Takahiro Niikura, Takashi Iwakura, Takashi Omori, Sang Yang Lee, Yoshitada Sakai, Toshihiro Akisue, Keisuke Oe, Tomoaki Fukui, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  Nov. 2019, BMC Musculoskeletal Disorders, 20(1) (1), 563 - 563, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Adequate Positioning of the Tibial Component Is Key to Avoiding Bearing Impingement in Oxford Unicompartmental Knee Arthroplasty

  Tomoyuki Kamenaga, Takafumi Hiranaka, Koji Takayama, Masanori Tsubosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2019, Journal of Arthroplasty, 34(11) (11), 2606 - 2613, English, International magazine

  [Refereed]

  Scientific journal


• Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

  Yohei Kawakami, William S. Hambright, Koji Takayama, Xiaodong Mu, Aiping Lu, James H. Cummins, Tomoyuki Matsumoto, Takashi Yurube, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Paul D. Robbins, Laura J. Niedernhofer, Johnny Huard

  Sep. 2019, Molecular Therapy - Methods and Clinical Development, 14, 64 - 76, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population

  Takahiro Niikura, Keisuke Oe, Yoshitada Sakai, Takashi Iwakura, Tomoaki Fukui, Hanako Nishimoto, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Akihiro Maruo, Yukihisa Yagata, Kenta Kishimoto, Atsushi Sakurai, Ryosuke Kuroda

  Sep. 2019, Journal of Orthopaedic Surgery, 27(3) (3), 2309499019877517

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 人工関節全置換術後に発症した急性膝窩動脈閉塞症を保存的に治療し得た2例

  前田 琢磨, 松本 知之, 高山 考治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 803 - 804, Japanese


• Charcot-Marie-Tooth病に伴う神経病性膝関節症に対し拘束型人工膝関節全置換術を施行した2例

  江原 豊, 松本 知之, 高山 孝治, 林 申也, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 805 - 806, Japanese


• Medial knee stability at flexion increases tibial internal rotation and knee flexion angle after posterior-stabilized total knee arthroplasty

  Tomoyuki Kamenaga, Koji Takayama, Kazunari Ishida, Hirotsugu Muratsu, Shinya Hayashi, Shingo Hashimoto, Yuichi Kuroda, Masanori Tsubosaka, Yoshinori Takashima, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Aug. 2019, Clinical Biomechanics, 68, 16 - 22, English, International magazine

  [Refereed]

  Scientific journal


• Medial clavicle pseudarthrosis successfully treated with an inverted distal clavicle locking plate

  Yu Sasaki, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2019, Annals of Medicine and Surgery, 44, 1 - 4, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Influence of limb alignment and prosthetic orientation on patient-reported clinical outcomes in total knee arthroplasty

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Kyohei Nishida, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jul. 2019, Journal of Orthopaedic Science, 24(4) (4), 668 - 673, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study.

  Shinya Hayashi, Koji Fukuda, Toshihisa Maeda, Nobuaki Chinzei, Shinsuke Kihara, Yasushi Miura, Yoshitada Sakai, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takahiro Niikura, Ryosuke Kuroda

  Improving patient health-related quality of life (HRQOL) and prevention of bone fracture are important components of the treatment of osteoporosis. Our aim in this study was to evaluate the effect of denosumab treatment in improving HRQOL among patients with osteoporosis. Our analysis was based on 332 patients with osteoporosis, followed for 24 months. All patients received denosumab (60 mg) subcutaneously every 6 months. Bone mineral density (BMD) was assessed at the distal radius, with serum concentration of calcium, phosphate, P1NP, and TRACP5b also measured. HRQOL assessment included pain (visual analogue scale [VAS]) and the EQ-5D questionnaire. A multivariate analysis was performed to identify the possible confounders associated with deterioration in the EQ-5D utility score in response to denosumab treatment. Denosumab treatment yielded a 3.4% increase in BMD at 24 months. Serum levels of TRACP5b and P1NP decreased significantly, from baseline, at 6 months, with no effect on calcium and phosphate levels. Pain VAS and EQ-5D utility score improved significantly, from baseline, at 6 months, with the EQ-5D utility score correlating with the BMD at all time points of measurement over the 24-month period of observation. Knee osteoarthritis and multiple comorbidities were significantly associated with a worse HRQOL in response to denosumab treatment. Denosumab treatment increased BMD, with improvements in BMD correlating with improved HRQOL, supporting a possible benefit of using denosumab for the treatment of osteoporosis. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

  Jul. 2019, JBMR plus, 3(7) (7), e10191, English, International magazine

  [Refereed]

  Scientific journal


• Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration

  Yuichi Kuroda, Tomoyuki Matsumoto, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Shinsuke Kirizuki, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  Jun. 2019, Journal of Orthopaedic Research, 37(6) (6), 1376 - 1386, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ACL遺残組織温存の賛否 前十字靱帯再建術における遺残組織に含まれる血管由来細胞の治癒能

  松本 知之, 松下 雄彦, 星野 祐一, 荒木 大輔, 美舩 泰, 高山 孝治, 橋本 真吾, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 564 - 564, Japanese


• 【人工膝関節置換術をめぐる議論】Kinematic alignmentの臨床成績 靱帯バランスの影響

  松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 161 - 166, Japanese


• 【人工膝関節置換術をめぐる議論】後十字靱帯温存型人工膝関節全置換術(CR-TKA)における外側laxityは術後の屈曲可動域に影響を及ぼす因子である

  中野 直樹, 松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 191 - 195, Japanese


• Prediction of quadriceps strength recovery after anterior cruciate ligament reconstruction with a hamstring autograft: Decision tree analysis

  Yohei Shibata, Takehiko Matsushita, Daisuke Araki, Akihiro Kida, Kohei Takiguchi, Yuya Ueda, Kumiko Ono, Tomoyuki Matsumoto, Takahiro Niikura, Yoshitada Sakai, Ryosuke Kuroda

  Mar. 2019, Journal of Orthopaedic Science, 24(2) (2), 301 - 305, English, Domestic magazine

  [Refereed]

  Scientific journal


• Attenuation of osteoarthritis progression in mice following intra-articular administration of simvastatin-conjugated gelatin hydrogel

  Toshikazu Tanaka, Takehiko Matsushita, Kyohei Nishida, Koji Takayama, Kanto Nagai, Daisuke Araki, Tomoyuki Matsumoto, Yasuhiko Tabata, Ryosuke Kuroda

  Mar. 2019, Journal of Tissue Engineering and Regenerative Medicine, 13(3) (3), 423 - 432, English, International magazine

  [Refereed]

  Scientific journal


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• Analysis of anterior tibial subluxation to the femur at maximum extension in anterior cruciate ligament-deficient knees

  Kyohei Nishida, Takehiko Matsushita, Daisuke Araki, Hiroshi Sasaki, Toshikazu Tanaka, Yuichi Hoshino, Noriyuki Kanzaki, Tomoyuki Matsumoto, Kouki Nagamune, Takahiro Niikura, Masahiro Kurosaka, Ryosuke Kuroda

  Jan. 2019, Journal of Orthopaedic Surgery, 27(1) (1), 2309499019833606

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Periprosthetic Femoral Fracture with Characteristics of Atypical Femoral Fracture.

  Shuya Tanaka, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.

  2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Recurrent Hematomas following a Revision Total Hip Arthroplasty in Acquired Coagulation Factor XIII Deficiency.

  Yoshinori Takashima, Shingo Hashimoto, Tomoyuki Kamenaga, Masanori Tsubosaka, Yuichi Kuroda, Kazuhiro Takeuchi, Koji Takayama, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers. FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding. In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA). A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas. Her plasma FXIII activity showed a slight decrease (69%). Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it. The bleeding did not recur once the FXIII activity had returned to a normal level (76%). At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state. There has been no recurrence of a hematoma since. We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile. An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.

  2019, Case reports in orthopedics, 2019, 4038963 - 4038963, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Erratum to: Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation: p21 INCREASES SUSCEPTIBILITY TO OA AND INFLAMMATION (Journal of Bone and Mineral Research, (2017), 32, 5, (991-1001), 10.1002/jbmr.3080)

  Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  Dec. 2018, Journal of Bone and Mineral Research, 33(12) (12), 2242 - 2242, English, International magazine

  [Refereed]

  Scientific journal


• Computer-assisted surgery prevents complications during peri-acetabular osteotomy

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Nao Shibanuma, Kazunari Ishida, Kotaro Nishida, Ryosuke Kuroda

  Springer Verlag, Nov. 2018, International Orthopaedics, 42(11) (11), 2555 - 2561, English, International magazine

  [Refereed]

  Scientific journal


• Medial joint line elevation of the tibia measured during surgery has a significant correlation with the limb alignment changes following medial unicompartmental knee arthroplasty

  Yuichi Kuroda, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Masanori Tsubosaka, Takehiko Matsushita, Takahiro Niikura, Kotaro Nishida, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Verlag, Nov. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(11) (11), 3468 - 3473, English, International magazine

  [Refereed]

  Scientific journal


• Intraoperative soft tissue balance using novel medial preserving gap technique in posterior-stabilized total knee arthroplasty: comparison to measured resection technique

  Kanto Nagai, Hirotsugu Muratsu, Yutaro Kanda, Masanori Tsubosaka, Tomoyuki Kamenaga, Hidetoshi Miya, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(11) (11), 3474 - 3481, English, International magazine

  [Refereed]

  Scientific journal


• A prospective randomized comparative study to determine appropriate edoxaban administration period, to prevent deep vein thromboembolism in patients with total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Kazuki Kodato, Akihiko Toda, Hiroshi Sasaki, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2018, Journal of Orthopaedic Science, 23(6) (6), 1005 - 1010, English, Domestic magazine

  [Refereed]

  Scientific journal


• Posterior Reference Position Affects Intraoperative Kinematic and Soft Tissue Balance in Navigated Posterior-Stabilized Total Knee Arthroplasty

  Kazunari Ishida, Nao Shibanuma, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Churchill Livingstone Inc., Sep. 2018, Journal of Arthroplasty, 33(9) (9), 2851 - 2857, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of coronal prosthetic alignment after total knee arthroplasty using 3 computer-assisted navigation systems

  Hiroshi Sasaki, Kazunari Ishida, Nao Shibanuma, Koji Takayama, Shinya Hayashi, Shingo Hashimoto, Takahiro Niikura, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sep. 2018, Orthopedics, 41(5) (5), E621 - E628, English, International magazine

  [Refereed]

  Scientific journal


• The Influence of Postoperative Knee Stability on Patient Satisfaction in Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Kamenaga, Hirotsugu Muratsu, Yutaro Kanda, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  Churchill Livingstone Inc., Aug. 2018, Journal of Arthroplasty, 33(8) (8), 2475 - 2479, English, International magazine

  [Refereed]

  Scientific journal


• Heterologous Biosynthesis of Fungal Indole Sesquiterpene Sespendole.

  Kosei Kudo, Chengwei Liu, Tomoyuki Matsumoto, Atsushi Minami, Taro Ozaki, Hiroaki Toshima, Katsuya Gomi, Hideaki Oikawa

  Indole sesquiterpene sespendole, which has been isolated from the filamentous fungus Pseudobotrytis terrestris FKA-25, is a specific inhibitor of lipid droplet synthesis in mouse macrophages. The biosynthetic pathway that involves genes encoding six enzymes (spdEMBQHJ) was elucidated through heterologous expression of spd genes in Aspergillus oryzae, biotransformation experiments, and in vitro enzymatic reactions with a recombinant protein, thereby revealing the mechanism underlying the characteristic modification on the indole ring, catalyzed by a set of prenyltransferase (SpdE)/cytochrome P450 (SpdJ) enzymes. Functional analysis of the homologous genes encoding these enzymes involved in the biosynthesis of lolitrem allowed a biosynthetic pathway for the bicyclic ring skeleton fused to the indole ring to be proposed.

  Jul. 2018, Chembiochem : a European journal of chemical biology, 19(14) (14), 1492 - 1497, English, International magazine

  [Refereed]

  Scientific journal


• Relatively Loose Flexion Gap Improves Patient-Reported Clinical Scores in Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Koji Takayama, Hirotsugu Muratsu, Kazunari Ishida, Shingo Hashimoto, Shinya Hayashi, Ryosuke Kuroda

  Georg Thieme Verlag, Jul. 2018, Journal of Knee Surgery, 31(6) (6), 573 - 579, English, International magazine

  [Refereed]

  Scientific journal


• Patients with a Dorr type C femoral bone require attention for using a Summit cementless stem: Results of total hip arthroplasty after a minimum follow-up period of 5 years after insertion of a Summit cementless stem

  Masanori Tsubosaka, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto

  Elsevier, Jul. 2018, Journal of Orthopaedic Science, 23(4) (4), 671 - 675, English, Domestic magazine

  [Refereed]

  Scientific journal


• The medial tibial joint line elevation over 5 mm restrained the improvement of knee extension angle in unicompartmental knee arthroplasty

  Koji Takayama, Kazunari Ishida, Hirotsugu Muratsu, Yuichi Kuroda, Masanori Tsubosaka, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer Verlag, Jun. 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(6) (6), 1737 - 1742, English, International magazine

  [Refereed]

  Scientific journal


• Tibiofemoral rotational alignment affects flexion angles in navigated posterior-stabilized total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Akihiko Toda, Shinya Oka, Kazuki Kodato, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda

  Springer Verlag, May 2018, Knee Surgery, Sports Traumatology, Arthroscopy, 26(5) (5), 1532 - 1539, English, International magazine

  [Refereed]

  Scientific journal


• The Influence of Ruptured Scar Pattern on the Healing Potential of Anterior Cruciate Ligament Remnant Cells

  Shinsuke Kirizuki, Tomoyuki Matsumoto, Takeshi Ueha, Atsuo Uefuji, Takao Inokuchi, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  SAGE Publications Inc., May 2018, American Journal of Sports Medicine, 46(6) (6), 1382 - 1388, English, International magazine

  [Refereed]

  Scientific journal


• Navigated total Knee arthroplasty for osteoarthritis with extra-articular deformity

  Izumi Tani, Naoki Nakano, Koji Takayama, Kazunari Ishida, Ryosuke Kuroda, Tomoyuki Matsumoto

  Sociedade Brasileira de Ortopedia e Traumatologia, May 2018, Acta Ortopedica Brasileira, 26(3) (3), 170 - 174, English

  [Refereed]

  Scientific journal


• 動脈塞栓術で治療可能であった外傷性腸骨筋血腫の1例

  鎮西 伸顕, 抽冬 晃司, 松本 知之, 橋本 慎吾, 高山 孝治, 酒井 良忠, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2018, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 1, Japanese


• Depletion of aquaporin 1 decreased ADAMTS-4 expression in human chondrocytes

  Masahiko Haneda, Shinya Hayashi, Tomoyuki Matsumoto, Shingo Hashimoto, Koji Takayama, Nobuaki Chinzei, Shinsuke Kihara, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  Spandidos Publications, Apr. 2018, Molecular Medicine Reports, 17(4) (4), 4874 - 4882, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Analysis of Graft Length Change Patterns in Medial Patellofemoral Ligament Reconstruction via a Fluoroscopic Guidance Method

  Takehiko Matsushita, Daisuke Araki, Yuichi Hoshino, Shinya Oka, Kyohei Nishida, Toshikazu Tanaka, Nobuaki Miyaji, Noriyuki Kanzaki, Kazuyuki Ibaraki, Tomoyuki Matsumoto, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2018, American Journal of Sports Medicine, 46(5) (5), 1150 - 1157, English, International magazine

  [Refereed]

  Scientific journal


• Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice

  K. Nishida, T. Matsushita, K. Takayama, T. Tanaka, N. Miyaji, K. Ibaraki, D. Araki, N. Kanzaki, T. Matsumoto, R. Kuroda

  British Editorial Society of Bone and Joint Surgery, Mar. 2018, Bone and Joint Research, 7(3) (3), 252 - 262, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of Intraoperative Soft Tissue Balance Between Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty Performed by a Newly Developed Medial Preserving Gap Technique

  Masanori Tsubosaka, Hirotsugu Muratsu, Koji Takayama, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  Mar. 2018, Journal of Arthroplasty, 33(3) (3), 729 - 734, English, International magazine

  [Refereed]

  Scientific journal


• 前十字靱帯再建術-Update- 回旋不安定性の評価に基づくACL再建術の進歩

  星野 祐一, 荒木 大輔, 神崎 至幸, 松本 知之, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S445 - S445, Japanese


• Prothrombin time-international normalized ratio is a useful marker for edoxaban efficacy in preventing venous thromboembolism after total knee arthroplasty

  Kazuki Kodato, Kazunari Ishida, Nao Shibanuma, Akihiko Toda, Koji Takayama, Shinya Oka, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Springer-Verlag France, Jan. 2018, European Journal of Orthopaedic Surgery and Traumatology, 28(1) (1), 103 - 108, English, International magazine

  [Refereed]

  Scientific journal


• Post-cam clunk syndrome after posterior stabilized total knee arthroplasty as a sign of early femoral component loosening

  Akihiko Toda, Katsumasa Tei, Tomoyuki Matsumoto, Kazunari Ishida, Hiroshi Sasaki, Kazuki Kodato, Yuichiro Nishizawa, Shinsuke Kirizuki, Nao Shibanuma, Hiroomi Tateishi, Ryosuke Kuroda, Masahiro Kurosaka

  Elsevier (Singapore) Pte Ltd, Jan. 2018, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 11, 19 - 21, English, International magazine

  [Refereed]

  Scientific journal


• Minimally Invasive Treatment for Tibial Malrotation after Locked Intramedullary Nailing.

  Kyohei Takase, Sang Yang Lee, Takahiro Waki, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Rotational malreduction is a potential complication of intramedullary nailing for tibial shaft fractures. We experienced a symptomatic case of a 24° externally rotated malunion that we treated with minimally invasive corrective osteotomy. A 49-year-old man sustained a tibial shaft spiral fracture with a fibula fracture. He had been initially treated elsewhere with a reamed statically locked intramedullary nail. Bone union had been obtained, but he complained of asymmetry of his legs, difficulty walking and running, and the inability to ride a bicycle. We decided to perform corrective osteotomy in a minimally invasive fashion. After a 1 cm incision was made at the original fracture site, osteotomy for the affected tibia was performed with an osteotome after multiple efforts at drilling around the nail with the aim of retaining it. Fibula osteotomy was also performed at the same level. Two Kirschner wires that created an affected rotational angle between the fragments were inserted as a guide for correction. The distal locking screws were removed. Correct rotation was regained by matching the two wires in a straight line. Finally, the distal locking screws were inserted into new holes. The patient obtained bony union and has returned to his preinjury activities with no symptoms.

  2018, Case reports in orthopedics, 2018, 4190670 - 4190670, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Locking plate osteosynthesis for a femoral fracture and subsequent nonunion in a patient with osteopetrosis

  Tomoya Matsuo, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  2018, International Journal of Surgery Case Reports, 51, 395 - 399, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Triweekly administration of parathyroid hormone (1-34) accelerates bone healing in a rat refractory fracture model

  Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Dec. 2017, BMC Musculoskeletal Disorders, 18(1) (1), 545 - 545, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Remaining mild varus limb alignment leads to better clinical outcome in total knee arthroplasty for varus osteoarthritis

  Kyohei Nishida, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Naoki Nakano, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(11) (11), 3488 - 3494, English, International magazine

  [Refereed]

  Scientific journal


• Posterior condylar offset influences the intraoperative soft tissue balance during posterior-stabilized total knee arthroplasty

  Masanori Tsubosaka, Koji Takayama, Shinya Oka, Hirotsugu Muratsu, Ryosuke Kuroda, Tomoyuki Matsumoto

  Nov. 2017, Journal of Orthopaedic Science, 22(6) (6), 1071 - 1076, English, Domestic magazine

  [Refereed]

  Scientific journal


• Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Kotaro Nishida, Kazunari Ishida, Ryosuke Kuroda

  Nov. 2017, JOURNAL OF ORTHOPAEDIC SURGERY, 25(3) (3), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors affecting quadriceps strength recovery after anterior cruciate ligament reconstruction with hamstring autografts in athletes

  Yuya Ueda, Takehiko Matsushita, Daisuke Araki, Akihiro Kida, Kohei Takiguchi, Yohei Shibata, Kumiko Ono, Rei Ono, Tomoyuki Matsumoto, Koji Takayama, Yoshitada Sakai, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(10) (10), 3213 - 3219, English, International magazine

  [Refereed]

  Scientific journal


• The Influence of Joint Distraction Force on the Soft-Tissue Balance Using Modified Gap-Balancing Technique in Posterior-Stabilized Total Knee Arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Yoshiki Takeoka, Masanori Tsubosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2017, Journal of Arthroplasty, 32(10) (10), 2995 - 2999, English, International magazine

  [Refereed]

  Scientific journal


• Radiographic analysis of the lower limbs using the hip–calcaneus line in healthy individuals and in patients with varus knee osteoarthritis

  Toshikazu Tanaka, Koji Takayama, Shingo Hashimoto, Noriyuki Kanzaki, Shinya Hayashi, Ryosuke Kuroda, Tomoyuki Matsumoto

  Oct. 2017, Knee, 24(5) (5), 1146 - 1152, English, International magazine

  [Refereed]

  Scientific journal


• Risk factors for failure of revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device

  Shinya Hayashi, Takayuki Nishiyama, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Kotaro Nishida, Ryosuke Kuroda

  Sep. 2017, BMC Musculoskeletal Disorders, 18(1) (1), 382 - 382, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Pseudoaneurysm of the articular branch of the descending genicular artery following double-bundle anterior cruciate ligament reconstruction

  Masanori Tsubosaka, Takehiko Matsushita, Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiro Kurosaka

  Sep. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(9) (9), 2721 - 2724, English, International magazine

  [Refereed]

  Scientific journal


• Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA

  Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Kotaro Nishida, Kazunari Ishida, Ryosuke Kuroda

  Sep. 2017, Journal of Orthopaedic Surgery, 25(3) (3), 2309499017739478

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響

  桐月 伸輔, 松本 知之, 黒田 雄一, 竹内 一裕, 羽田 勝彦, 井口 貴雄, 高山 孝治, 荒木 大輔, 橋本 慎吾, 林 申也, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1874 - S1874, Japanese


• Effects of Suture and Tourniquet on Intraoperative Kinematics in Navigated Total Knee Arthroplasty

  Masanori Tsubosaka, Kazunari Ishida, Hiroshi Sasaki, Nao Shibanuma, Ryosuke Kuroda, Tomoyuki Matsumoto

  Jun. 2017, Journal of Arthroplasty, 32(6) (6), 1824 - 1828, English, International magazine

  [Refereed]

  Scientific journal


• Factors associated with the status of meniscal tears following meniscal repair concomitant with anterior cruciate ligament reconstruction

  Takehiko Matsushita, Kanto Nagai, Daisuke Araki, Toshikazu Tanaka, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  May 2017, Connective Tissue Research, 58(3-4) (3-4), 386 - 392

  [Refereed]

  Scientific journal


• Assessment in primary TKA: Intraoperative assessment tensor

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Ryosuke Kuroda

  May 2017, Soft Tissue Balancing in Total Knee Arthroplasty, 153 - 169

  In book


• Radiological and clinical comparison of kinematically versus mechanically aligned total knee arthroplasty

  T. Matsumoto, K. Takayama, K. Ishida, S. Hayashi, S. Hashimoto, R. Kuroda

  May 2017, Bone and Joint Journal, 99B(5) (5), 640 - 646, English, International magazine

  [Refereed]

  Scientific journal


• Multiple Revision Surgeries and Acetabular Bone Defect Size May Predict Daily Activity After Revision Total Hip Arthroplasty

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Ryosuke Kuroda

  May 2017, Journal of Arthroplasty, 32(5) (5), 1606 - 1611, English, International magazine

  [Refereed]

  Scientific journal


• Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation

  Shinsuke Kihara, Shinya Hayashi, Shingo Hashimoto, Noriyuki Kanzaki, Koji Takayama, Tomoyuki Matsumoto, Nobuaki Chinzei, Kenjiro Iwasa, Masahiko Haneda, Kazuhiro Takeuchi, Kotaro Nishida, Ryosuke Kuroda

  May 2017, Journal of Bone and Mineral Research, 32(5) (5), 991 - 1001, English, International magazine

  [Refereed]

  Scientific journal


• Influence of the Injury-to-Surgery Interval on the Healing Potential of Human Anterior Cruciate Ligament-Derived Cells

  Takao Inokuchi, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Shurong Zhang, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda

  May 2017, American Journal of Sports Medicine, 45(6) (6), 1359 - 1369, English, International magazine

  [Refereed]

  Scientific journal


• New proximal femoral compaction blade provides strong antirotation stability of the femoral head

  Shinya Hayashi, Yukiaki Hirata, Daiki Okamoto, Satoshi Kakunai, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Takahiro Niikura, Takaaki Fujishiro, Takafumi Hiranaka, Kotaro Nishida, Ryosuke Kuroda

  May 2017, Orthopedics, 40(3) (3), e491 - e494, English, International magazine

  [Refereed]

  Scientific journal


• Kinematically aligned total knee arthroplasty: Alternative standardized technique?

  Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda

  AME Publishing Company, May 2017, Annals of Translational Medicine, 5(Suppl 1) (Suppl 1), S10, English, International magazine

  [Refereed]

  Scientific journal


• 関節の再生医療2017 軟骨細胞による再生医療

  黒田 良祐, 松下 雄彦, 松本 知之, 星野 祐一, 神崎 至幸, 荒木 大輔

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2017, JOSKAS, 42(4) (4), 247 - 247, Japanese


• Clinical outcomes and biomechanical analysis of posterolateral bundle augmentation in patients with partial anterior cruciate ligament tears

  Takehiko Matsushita, Ryosuke Kuroda, Yuichiro Nishizawa, Daisuke Araki, Yuichi Hoshino, Kanto Nagai, Tomoyuki Matsumoto, Masahiro Kurosaka

  Apr. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(4) (4), 1279 - 1289, English, International magazine

  [Refereed]

  Scientific journal


• Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritis

  Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Tomoyuki Matsumoto, Ken Takebe, Yasuhiro Terashima, Ryosuke Kuroda, Yoshitada Sakai, Kazunari Ishida, Kotaro Nishida

  Apr. 2017, Acta reumatologica portuguesa, 42(2) (2), 150 - 154, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Anterior Cruciate Ligament-Derived Stem Cells Transduced with BMP2 Accelerate Graft-Bone Integration after ACL Reconstruction

  Yohei Kawakami, Koji Takayama, Tomoyuki Matsumoto, Ying Tang, Bing Wang, Yutaka Mifune, James H. Cummins, Ryan J. Warth, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Mar. 2017, American Journal of Sports Medicine, 45(3) (3), 584 - 597, English, International magazine

  [Refereed]

  Scientific journal


• A new quantitative radiographic measurement of patella for patellar instability using the lateral plain radiograph: ‘patellar width ratio’

  Ryosuke Kuroda, Kanto Nagai, Takehiko Matsushita, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka

  Jan. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(1) (1), 123 - 128, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic potential of endothelial progenitor cells in the field of orthopaedics

  Yohei Kawakami, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Kunj G. Patel, Garth N. Walker, Masahiro Kurosaka, Ryosuke Kuroda

  Jan. 2017, Current Stem Cell Research and Therapy, 12(1) (1), 3 - 13, English, International magazine

  [Refereed]

  Scientific journal


• High tibial osteotomy combined with cancellous bone graft and osteochondral autograft transplantation in a patient with massive osteochondral defects in the medial femoral condyle: A case report and literature review

  Takehiko Matsushita, Shu Watanabe, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Ltd, Jan. 2017, Journal of Orthopaedic Surgery, 25(1) (1), 2309499016685016 - 2309499016685016, English, International magazine

  [Refereed]

  Scientific journal


• Mobile Bearing Total Knee Arthroplasty for Valgus Knee Osteoarthritis with Permanent Patellar Dislocation: A Case Report and Review of the Literature.

  Kohei Kamada, Tomoyuki Matsumoto, Koji Takayama, Daisuke Araki, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda

  Permanent patellar dislocation with tibiofemoral joint osteoarthritis is a relatively rare condition. To treat this condition, total knee arthroplasty with proximal or distal realignment of the extensor mechanism has been reported. We report a challenging case of an 80-year-old woman diagnosed with permanent patellar dislocation with tibiofemoral joint osteoarthritis treated by a mobile bearing total knee arthroplasty utilizing navigation system. Lateral retinaculum release was performed to improve patellar tracking; other proximal or distal realignment of the extensor mechanism was not necessary. Postoperative radiographs show stable patellar tracking and recurrent patellar dislocation was not observed. This clinical case indicates that the implant's precise alignment and rotation during total knee arthroplasty could settle anatomical abnormalities of permanent patellar dislocation and the mobile bearing insert could contribute to stabilizing patellar tracking.

  2017, Case reports in orthopedics, 2017, 1230412 - 1230412, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Two cases of late medial instability of the knee due to hip disease after total knee arthroplasty

  Masanori Tsubosaka, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Ryosuke Kuroda

  Elsevier Ltd, 2017, International Journal of Surgery Case Reports, 37, 200 - 204, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The contribution of intraoperative medial compartment stability to post-operative knee flexion angle in unicompartmental knee arthroplasty

  Tokio Matsuzaki, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Koji Takayama, Kanto Nagai, Naoki Nakano, Kyohei Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2017, Knee Surgery, Sports Traumatology, Arthroscopy, 25(1) (1), 272 - 276, English, International magazine

  [Refereed]

  Scientific journal


• Subjective evaluation before and after total knee arthroplasty using the 2011 Knee Society Score

  Yuichi Kuroda, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2016, Knee, 23(6) (6), 964 - 967, English, International magazine

  [Refereed]

  Scientific journal


• 膝前十字靱帯再建術後の下肢における筋肉の量および質と膝伸展筋力およびパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (公社)日本理学療法士協会, Oct. 2016, 理学療法学, 43(Suppl.2) (Suppl.2), P - 3, Japanese

  [Refereed]


• 半月板縫合術 適応拡大の功罪 半月板縫合術後の長期成績・再断裂

  松下 雄彦, 田中 聡一, 荒木 大輔, 松本 知之, 高山 孝治, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 86 - 86, Japanese


• 難治性習慣性膝蓋骨脱臼に対し大腿骨遠位内反骨切り術にて良好な結果を得た1例

  立花 章太郎, 松下 雄彦, 荒木 大輔, 高山 孝治, 松本 知之, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 133 - 133, Japanese


• Navigation-based tibial rotation at 90° of flexion is associated with better range of motion in navigated total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Yuji Hiroshima, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2016, Knee Surgery, Sports Traumatology, Arthroscopy, 24(8) (8), 2447 - 2452, English, International magazine

  [Refereed]

  Scientific journal


• TKAの機能向上をめざしたバイオメカニクス研究 テンサーによる評価と術後成績

  松本 知之, 高山 孝治, 村津 裕嗣, 石田 一成, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1452 - S1452, Japanese


• 新規OA治療の標的分子探索 SIRT1による軟骨変性と変形性関節症の抑制

  松下 雄彦, 西田 京平, 松崎 時夫, 高山 孝治, 松本 知之, 荒木 大輔, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1457 - S1457, Japanese


• Biomechanical Function of Anterior Cruciate Ligament Remnants: Quantitative Measurement With a 3-Dimensional Electromagnetic Measurement System

  Kanto Nagai, Daisuke Araki, Takehiko Matsushita, Yuichiro Nishizawa, Yuichi Hoshino, Tomoyuki Matsumoto, Koji Takayama, Naoki Nakano, Kouki Nagamune, Masahiro Kurosaka, Ryosuke Kuroda

  Jul. 2016, Arthroscopy - Journal of Arthroscopic and Related Surgery, 32(7) (7), 1359 - 1366, English, International magazine

  [Refereed]

  Scientific journal


• Local Administration of Simvastatin Stimulates Healing of an Avascular Meniscus in a Rabbit Model of a Meniscal Defect

  Shurong Zhang, Takehiko Matsushita, Ryosuke Kuroda, Kyohei Nishida, Tokio Matsuzaki, Tomoyuki Matsumoto, Koji Takayama, Kanto Nagai, Shinya Oka, Yasuhiko Tabata, Kouki Nagamune, Masahiro Kurosaka

  Jul. 2016, American Journal of Sports Medicine, 44(7) (7), 1735 - 1743, English, International magazine

  [Refereed]

  Scientific journal


• Open-wedge high tibial osteotomyにおけるナビゲーションシステムの有用性の検討

  桐月 伸輔, 松下 雄彦, 荒木 大輔, 岡 真也, 松本 知之, 高山 孝治, 宮地 伸晃, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 189 - 189, Japanese


• 外反型変形性膝関節症に対する大腿骨遠位内反骨切り術の術後成績

  井口 貴雄, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 西田 京平, 桐月 伸輔, 田中 聡一, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 204 - 204, Japanese


• 単顆型人工膝関節置換術の手術手技 UKAにおける軟部組織評価

  高山 孝治, 松本 知之, 村津 裕嗣, 石田 一成, 柴沼 均, 荒木 大輔, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 324 - 324, Japanese


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  西田 京平, 荒木 大輔, 松下 雄彦, 井口 貴雄, 桐月 伸輔, 田中 聡一, 高山 孝治, 松本 知之, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 369 - 369, Japanese


• 膝前十字靱帯再建術前後における膝最大伸展位での脛骨前方偏位の検討

  荒木 大輔, 松下 雄彦, 西田 京平, 桐月 伸輔, 田中 聡一, 井口 貴雄, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 369 - 369, Japanese


• 若年患者における前十字靱帯再建術の術後成績

  張 樹蓉, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 黒田 雄一, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 378 - 378, Japanese


• 膝関節の再生医療 軟骨変性抑制による膝関節再生

  松下 雄彦, 黒田 良祐, 高山 孝治, 西田 京平, 田中 聡一, 松本 知之, 荒木 大輔, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 390 - 390, Japanese


• 内側膝蓋大腿靱帯再建術におけるX線透視下に決定した大腿骨骨孔位置での再建靱帯の長さ変化の検討

  松下 雄彦, 黒田 良祐, 荒木 大輔, 星野 祐一, 佐々木 謙, 岡 真也, 松本 知之, 高山 孝治, 黒田 雄一, 宮地 伸晃, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 411 - 411, Japanese


• 外側半月板手術後のスポーツ復帰と予後 外側半月板手術後のスポーツ復帰

  黒田 良祐, 松下 雄彦, 田中 聡一, 荒木 大輔, 松本 知之

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2016, JOSKAS, 41(4) (4), 515 - 515, Japanese


• The influence of posterior tibial slope changes on joint gap and range of motion in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2016, Knee, 23(3) (3), 517 - 522, English, International magazine

  [Refereed]

  Scientific journal


• The influence of intraoperative soft tissue balance on patellar pressure in posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Nao Shibanuma, Koji Takayama, Hiroshi Sasaki, Kazunari Ishida, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2016, Knee, 23(3) (3), 540 - 544, English, International magazine

  [Refereed]

  Scientific journal


• Medial Gap Techniqueを用いたCR-TKAとPS-TKAの術中軟部組織バランスの比較

  竹森 俊幸, 村津 裕嗣, 松本 知之, 鈴木 孝洋, 壺坂 正徳, 大島 隆司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2016, JOSKAS, 41(2) (2), 324 - 325, Japanese


• Periarticular multimodal drug injection improves post-operative pain and functional recovery after total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Katsumasa Tei, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, Journal of Orthopaedic Science, 21(2) (2), 178 - 183, English, Domestic magazine

  [Refereed]

  Scientific journal


• Coronal lower limb alignment in normal knees-A radiographic analysis of 797 normal knee subjects

  Naoki Nakano, Tomoyuki Matsumoto, Masataka Hashimura, Koji Takayama, Kazunari Ishida, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2016, Knee, 23(2) (2), 209 - 213, English, International magazine

  [Refereed]

  Scientific journal


• [Prolonged Disturbance of Consciousness following Preoperative Glycerin Enema in an Elderly Patient].

  Ishizaki T, Hayashi H, Matsumoto T

  克誠堂出版, Mar. 2016, Masui. The Japanese journal of anesthesiology, 65(3) (3), 296 - 298, Japanese

  [Refereed]


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  西田 京平, 荒木 大輔, 松下 雄彦, 井口 貴雄, 桐月 伸輔, 田中 聡一, 高山 孝治, 松本 知之, 黒坂 昌弘, 黒田 良祐

  関西関節鏡・膝研究会, Mar. 2016, 関西関節鏡・膝研究会プログラム・演題抄録, 28回, 16 - 16, Japanese


• 膝離断性骨軟骨炎 若年者膝離断性骨軟骨炎の治療

  松下 雄彦, 黒田 良祐, 荒木 大輔, 桐月 伸輔, 松本 知之, 高山 孝治, 星野 祐一, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2016, 関西関節鏡・膝研究会プログラム・演題抄録, 28回, 37 - 37, Japanese


• 当院におけるスポーツ選手への半月板単独損傷に対する半月板縫合術の治療成績

  田中 聡一, 松下 雄彦, 黒田 良祐, 荒木 大輔, 松本 知之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2016, 中部日本整形外科災害外科学会雑誌, 59(春季学会) (春季学会), 166 - 166, Japanese


• 単顆型人工膝関節置換術におけるjoint line変化と術後可動域の関係

  高山 孝治, 松本 知之, 村津 裕嗣, 石田 一成, 柴沼 均, 荒木 大輔, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S111 - S111, Japanese


• Postoperative Knee Flexion Angle Is Affected by Lateral Laxity in Cruciate-Retaining Total Knee Arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Koji Takayama, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, Journal of Arthroplasty, 31(2) (2), 401 - 405, English, International magazine

  [Refereed]

  Scientific journal


• An evaluation method of hardness on quantitative measurement system for lachman test using force sensor

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Feb. 2016, Information (Japan), 19(2) (2), 695 - 704

  Scientific journal


• Inaccurate rotational component position in image-free navigated unicompartmental knee arthroplasty

  Akihiko Toda, Kazunari Ishida, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Ryosuke Kuroda, Masahiro Kurosaka, Nao Shibanuma

  Elsevier (Singapore) Pte Ltd, Jan. 2016, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 3, 19 - 24, English, International magazine

  [Refereed]

  Scientific journal


• Revision total knee arthroplasty using the modern constrained condylar knee prosthesis

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  2016, Acta Ortopedica Brasileira, 24(6) (6), 304 - 308, English

  [Refereed]

  Scientific journal


• Navigation-based femorotibial rotation pattern correlated with flexion angle after total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Tokio Matsuzaki, Katsumasa Tei, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2016, Knee Surgery, Sports Traumatology, Arthroscopy, 24(1) (1), 89 - 95, English, International magazine

  [Refereed]

  Scientific journal


• 膝前十字靭帯再建術後の下肢における筋肉の量および質と膝伸展筋力およびパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  【はじめに，目的】膝前十字靭帯（以下ACL）再建術後では術側の筋力低下が問題となる。筋力低下の要因として，ACL再建術後では筋量減少など筋肉の量による要因と，神経筋機能低下など筋肉の質による要因のそれぞれが報告されている。しかし両者を包括的に検討した報告は数少ない。またパフォーマンスとそれぞれの関連についての報告はない。機能低下の要因を検討することはリハビリテーションの内容を選択する上で重要である。そこで本研究では，ACL再建術後6ヶ月の術側下肢における筋肉の量および質と，膝伸展筋力およびパフォーマンスの関連について横断的に検討することとした。【方法】2011年7月から2012年9月に当院または当科関連病院にてHamstrings腱を用いたACL単独再建術を施行し，術後6ヶ月に膝関節機能および身体組成を測定し得た連続71名（男性43名，年齢22.8±8.1歳）を対象とした。除外基準は反対側受傷および術側既往歴がある者，膝蓋腱をgraftとして用いた者とした。個人特性は性別，年齢，BMI，受傷前Tegner activity scale（以下TAS）を聴取した。膝関節機能は膝伸展筋力とパフォーマンスとして片脚幅跳び距離を測定した。膝伸展筋力はMYORET RZ-450を用いて等尺90°での最大膝伸展筋力を測定した。片脚幅跳び距離は2回の施行での最大跳躍距離とした。身体組成ではYamato DF860を用い下肢筋肉量を測定した。筋肉の量の評価として，体重あたりの術側下肢筋肉量（以下%筋肉量）を算出した。筋肉の質の評価として，術側の下肢筋量あたりの膝伸展筋力（以下Muscle Quality：MQ）を算出した。統計解析として，術側膝伸展筋力と片脚幅跳び距離それぞれと各項目の関連について単変量解析により検討した。また術側膝伸展筋力と片脚幅跳び距離それぞれを従属変数とし，単変量解析にて有意な関連を示した変数を独立変数とした重回帰分析を実施した。統計はJMP ver12.0を用い，有意水準は5%未満とした。【結果】単変量解析の結果，術側膝伸展筋力は男性で有意に強く（男性205.3±67.9 Nm，女性118.6±29.5 Nm），BMI（r=0.57），TAS（r=0.35），%筋肉量（r=0.41）およびMQ（r=0.80）と有意な関連を認めた。術側片脚幅跳び距離は男性で有意に長く（男性1.47±0.26 m，女性1.09±0.19 m），TAS（r=0.34），%筋肉量（r=0.50）およびMQ（r=0.38）と有意な関連を認めた。重回帰分析の結果，術側膝伸展筋力では性別（β=0.14），BMI（β=0.37），%筋肉量（β=0.29）およびMQ（β=0.61）が独立した因子として抽出された（R²=0.93）。術側片脚幅跳び距離では性別（β=0.42）およびMQ（β=0.69）が独立した因子として抽出された（R²=0.47）。【結論】ACL再建術後6ヶ月では，術側膝伸展筋力には性別，BMIに関わらず筋肉の量および質がそれぞれ独立して関連していた。一方片脚幅跳び距離には筋肉の質は独立して関連していたが，量は独立した関連を認めなかった。本研究より，量のみならず筋肉の質の着目した介入の重要性が示唆される。

  公益社団法人 日本理学療法士協会, 2016, 理学療法学Supplement, 2015, 1297 - 1297, Japanese


• 当院におけるスポーツ選手への半月板単独損傷に対する半月板縫合術の治療成績

  田中 聡一, 松下 雄彦, 黒田 良祐, 荒木 大輔, 松本 知之, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2016, スポーツ傷害, 21, 19 - 19, Japanese


• Strategies to enhance biological tendon-bone healing in anterior cruciate ligament reconstruction

  Tomoyuki Matsumoto, Ryosuke Kuroda

  Springer Japan, Jan. 2016, ACL Injury and its Treatment, 537 - 584, English

  [Refereed]

  In book


• 膝前十字靱帯再建術後の下肢における筋肉の量および質とパフォーマンスとの関連

  上田 雄也, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2016, スポーツ傷害, 21, 37 - 37, Japanese

  [Refereed]


• Anterior cruciate ligament remnant tissue harvested within 3-months after injury predicts higher healing potential

  Shurong Zhang, Tomoyuki Matsumoto, Atsuo Uefuji, Takehiko Matsushita, Koji Takayama, Daisuke Araki, Naoki Nakano, Kanto Nagai, Tokio Matsuzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2015, BMC Musculoskeletal Disorders, 16(1) (1), 390 - 390, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intermediate-term comparison of posterior cruciate-retaining versus posterior-stabilized total knee arthroplasty using the new knee scoring system

  Yohei Kawakami, Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Naoki Nakano, Takehiko Matsushita, Yuichi Kuroda, Kunji Patel, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2015, Orthopedics, 38(12) (12), e1127 - e1132, English, International magazine

  [Refereed]

  Scientific journal


• p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation

  Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Nobuaki Chinzei, Shinsuke Kihara, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2015, Arthritis Research and Therapy, 17(1) (1), 314 - 314, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Fibular axes are not a reliable landmark for tibial mechanical axes of osteoarthritic knees that underwent total knee arthroplasty

  Yuichi Kuroda, Kazunari Ishida, Tomoyuki Matsumoto, Hiroshi Sasaki, Tokio Matsuzaki, Shinya Oka, Koji Takayama, Katsumasa Tei, Takehiko Matsushita, Nobuhiro Tsumura, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2015, Knee Surgery, Sports Traumatology, Arthroscopy, 23(11) (11), 3362 - 3367, English, International magazine

  [Refereed]

  Scientific journal


• Quantitative comparison of the pivot shift test results before and after anterior cruciate ligament reconstruction by using the three-dimensional electromagnetic measurement system

  Kanto Nagai, Yuichi Hoshino, Yuichiro Nishizawa, Daisuke Araki, Takehiko Matsushita, Tomoyuki Matsumoto, Koji Takayama, Kouki Nagamune, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2015, Knee Surgery, Sports Traumatology, Arthroscopy, 23(10) (10), 2876 - 2881, English, International magazine

  [Refereed]

  Scientific journal


• 内反型変形性膝関節症に対する人工膝関節全置換術術後下肢アライメントと臨床成績の関係

  西田京平, 松本知之, 高山孝治, 中野直樹, 井口貴雄, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2015, 日本関節病学会誌, 34(3号) (3号), 374, Japanese

  [Refereed]

  Research society


• 内側膝蓋大腿靱帯再建術後の主観的評価に影響を及ぼす因子の検討

  柴田洋平, 松下雄彦, Kuroda Ryosuke, 荒木大輔, 瀧口耕平, 上田雄也, 松本知之, 高山孝治, Sakai Yoshitada, Kurosaka Masahiro

  Oct. 2015, 日本臨床スポーツ医学会誌, 23(4号) (4号), S181, Japanese

  [Refereed]

  Research society


• 人工膝関節置換術における新しい挑戦と将来展望 TKAで目指すべきアライメントと手術手技 Kinematic Alignmentも含めて

  松本知之, 西田京平, 高山孝治, 石田一成, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Oct. 2015, 日本関節病学会誌, 34(3号) (3号), 450, Japanese

  [Refereed][Invited]

  Research society


• Semimembranosus Release Reduces Tibial Internal Rotation and Flexion Angle in Cruciate-Retaining Total Knee Arthroplasty

  Tomoyuki Matsumoto, Koji Takayama, Hirotsugu Muratsu, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2015, Journal of Arthroplasty, 30(9) (9), 1537 - 1541, English, International magazine

  [Refereed]

  Scientific journal


• Factors influencing the outcome of deep infection following total knee arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Hirotsugu Muratsu, Takafumi Hiranaka, Ryosuke Kuroda, Masahiro Kurosaka

  Sep. 2015, Knee, 22(4) (4), 328 - 332, English, International magazine

  [Refereed]

  Scientific journal


• バイオメカニクスによる運動器疾患の病態解明 前十字靱帯損傷膝の定量評価

  Kuroda Ryosuke, 松下雄彦, 星野祐一, 長宗高樹, 荒木大輔, 松本知之, Kurosaka Masahiro

  Sep. 2015, 日本整形外科学会雑誌, 89(8号) (8号), S1744, Japanese

  [Refereed][Invited]

  Research society


• Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

  K. Nagai, T. Matsushita, T. Matsuzaki, K. Takayama, T. Matsumoto, R. Kuroda, M. Kurosaka

  Aug. 2015, Osteoarthritis and Cartilage, 23(8) (8), 1412 - 1420

  [Refereed]

  Scientific journal


• The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation

  Koji Takayama, Yohei Kawakami, Yutaka Mifune, Tomoyuki Matsumoto, Ying Tang, James H. Cummins, Nick Greco, Ryosuke Kuroda, Masahiro Kurosaka, Bing Wang, Freddie H. Fu, Johnny Huard

  Aug. 2015, Biomaterials, 60, 9 - 19, English, International magazine

  [Refereed]

  Scientific journal


• Superior potential of CD34-positive cells compared to total mononuclear cells for healing of nonunion following bone fracture

  Tomoaki Fukui, Yutaka Mifune, Tomoyuki Matsumoto, Taro Shoji, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Hiroshi Akimaru, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Cantas Alev, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  Jul. 2015, Cell Transplantation, 24(7) (7), 1379 - 1393, English, International magazine

  [Refereed]

  Scientific journal


• Influence of Intraoperative Soft Tissue Balance on Postoperative Active Knee Extension in Posterior-Stabilized Total Knee Arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Shunsuke Takahara, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2015, Journal of Arthroplasty, 30(7) (7), 1155 - 1159, English, International magazine

  [Refereed]

  Scientific journal


• 内側膝蓋大腿靱帯再建術後に自家培養軟骨細胞移植術および脛骨粗面前内方移行術を施行した1例

  宮崎邦彦, Kuroda Ryosuke, Matsushita Takehiko, 荒木大輔, 松本知之, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Jul. 2015, 中部日本整形外科災害外科学会雑誌, 58(4号) (4号), 689 - 690, Japanese

  [Refereed]

  Scientific journal


• Factors affecting intraoperative kinematic patterns and flexion angles in navigated total knee arthroplasty

  Kazunari Ishida, Nao Shibanuma, Tomoyuki Matsumoto, Hiroshi Sasaki, Koji Takayama, Akihiko Toda, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2015, Knee Surgery, Sports Traumatology, Arthroscopy, 23(6) (6), 1741 - 1747, English, International magazine

  [Refereed]

  Scientific journal


• Treatment of 50 deep infections after total knee arthroplasty

  Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Kanto Nagai, Hirotsugu Muratsu, Yuichi Hida, Takafumi Hiranaka, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2015, Orthopedics, 38(6) (6), e529 - e535, English, International magazine

  [Refereed]

  Scientific journal


• 膝前十字靱帯再建術後の筋力回復に影響を及ぼす因子の検討

  井口貴雄, 松下雄彦, Kuroda Ryosuke, 荒木大輔, 柴田洋平, 松本知之, 高山孝治, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 550, Japanese

  Research society


• 膝蓋骨疲労骨折に対する骨接合術後に、偽関節を来したプロバレーボール選手の一例

  森昭嘉, Kuroda Ryosuke, 荒木大輔, 松下雄彦, 高山孝治, 松本知之, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 201, Japanese

  [Refereed]

  Research society


• 軟骨再生の臨床経験

  Kuroda Ryosuke, 松下雄彦, 松本知之, 星野祐一, 荒木大輔, 高山孝治, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 203, Japanese

  [Invited]

  Research society


• 人工膝関節置換術における術中関節ギャップと内外側軟部バランスの意義 術後臨床成績への影響

  松本知之, 高山孝治, 村津裕嗣, 石田一成, 中野直樹, 上藤淳郎, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 337, Japanese

  Research society


• 術後感染を併発した人工膝関節全置換術症例の予後に影響する因子 深部感染51症例の検討

  中野直樹, 松本知之, 石田一成, 津村暢宏, 村津裕嗣, 平中崇文, 高山孝治, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Jun. 2015, JOSKAS, 40(4号) (4号), 223, Japanese

  Research society


• スポーツ競技者における膝前十字靱帯再建術後早期の膝伸展筋力回復に影響を及ぼす因子の多変量解析を用いた検討

  西田京平, 上田雄也, 荒木大輔, 松下雄彦, 松本知之, 高山孝治, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2015, JOSKAS, 40(4号) (4号), 123, Japanese

  [Refereed]

  Research society


• Reconstitution of biosynthetic machinery for the synthesis of the highly elaborated indole diterpene penitrem.

  Liu C, Tagami K, Minami A, Matsumoto T, Frisvad JC, Suzuki H, Ishikawa J, Gomi K, Oikawa H

  May 2015, Angewandte Chemie (International ed. in English), 54(19) (19), 5748 - 5752

  [Refereed]


• スポーツ競技者における膝前十字靱帯再建術後早期の良好な膝伸展筋力回復に関する要因の検討

  荒木 大輔, 松下 雄彦, 松本 知之, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (公社)日本リハビリテーション医学会, May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254 - S254, Japanese


• 反復性膝蓋骨脱臼患者における内側膝蓋大腿靱帯再建術前後の膝伸展筋力の変化

  松下雄彦, Kuroda Ryosuke, 松本知之, 荒木大輔, 酒井良忠, Kurosaka Masahiro

  May 2015, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S217, Japanese

  [Refereed]

  Research society


• スポーツ実施者における膝前十字靱帯再建術後6ヵ月での膝伸展筋力回復に関連する因子およびカットオフ値の検討

  上田 雄也, 荒木 大輔, 松下 雄彦, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 小野 玲, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (公社)日本理学療法士協会, Apr. 2015, 理学療法学, 42(Suppl.2) (Suppl.2), O - 0036, Japanese

  [Refereed]


• The tibia first technique with tensor measurement is useful to predict the soft tissue tension after implantation in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Kazunari Ishida, Nao Shibanuma, Daisuke Araki, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, International Orthopaedics, 39(4) (4), 667 - 671, English, International magazine

  [Refereed]

  Scientific journal


• Age-dependent healing potential of anterior cruciate ligament remnant-derived cells

  Naoki Nakano, Tomoyuki Matsumoto, Koji Takayama, Takehiko Matsushita, Daisuke Araki, Atsuo Uefuji, Kanto Nagai, Shurong Zhang, Takao Inokuchi, Kyohei Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2015, American Journal of Sports Medicine, 43(3) (3), 700 - 708, English, International magazine

  [Refereed]

  Scientific journal


• 内側膝蓋大腿靱帯再建術後に自家培養軟骨細胞移植術および脛骨粗面前内方移行術を施行した一例

  宮崎 邦彦, 黒田 良祐, 松下 雄彦, 荒木 大輔, 松本 知之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Mar. 2015, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 102 - 102, Japanese


• 膝前十字靱帯再建術の新たなる展開 移植腱の骨内での癒合促進と術後筋力回復への新たなる試み

  Kurosaka Masahiro, Kuroda Ryosuke, 松下雄彦, 松本知之, 高山孝治, 酒井良忠

  Mar. 2015, 日本整形外科学会雑誌, 89(2号) (2号), S287, Japanese

  Research society


• 単顆型人工膝関節置換術における脛骨後方傾斜とcomponent gapの関係

  高山孝治, 松本知之, 村津裕嗣, 石田一成, 柴沼均, 荒木大輔, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S713, Japanese

  Research society


• 前十字靱帯解剖学的二重束再建術において大腿骨側骨孔間距離が術後骨孔拡大に及ぼす影響

  荒木大輔, Kuroda Ryosuke, 魚住洋祐, 長宗高樹, 松下雄彦, 松本知之, 高山孝治, 星野祐一, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S744, Japanese

  [Refereed]

  Research society


• Modern TKAに必要なアライメントとは 適切な冠状断アライメント

  松本知之, 西田京平, 高山孝治, 中野直樹, 松下雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2015, 日本整形外科学会雑誌, 89(3号) (3号), S574, Japanese

  [Refereed]

  Research society


• A radiographic analysis of alignment of the lower extremities - initiation and progression of varus-type knee osteoarthritis

  T. Matsumoto, M. Hashimura, K. Takayama, K. Ishida, Y. Kawakami, T. Matsuzaki, N. Nakano, T. Matsushita, R. Kuroda, M. Kurosaka

  Feb. 2015, Osteoarthritis and Cartilage, 23(2) (2), 217 - 223, English

  [Refereed]

  Scientific journal


• Results of total knee arthroplasty with NexGen LPS-Flex for osteoarthritis in the valgus knee: a study of 26 patients followed for a minimum of 2 years

  Naoki Nakano, Tomoyuki Matsumoto, Hirotsugu Muratsu, Takehiko Matsushita, Koji Takayama, Tokio Matsuzaki, Ryosuke Kuroda, Masahiro Kurosaka

  Springer-Verlag France, Feb. 2015, European Journal of Orthopaedic Surgery and Traumatology, 25(2) (2), 375 - 380, English, International magazine

  [Refereed]

  Scientific journal


• Acute Popliteal Artery Occlusion after Revision Total Knee Arthroplasty.

  Ryu Tsujimoto, Tomoyuki Matsumoto, Koji Takayama, Yohei Kawakami, Masato Kamimura, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Acute arterial occlusions are a rare complication of total knee arthroplasty (TKA). However, in revision TKA, the risk of such complications is higher and these complications can lead to amputation if not adequately treated. We describe a case of acute popliteal artery occlusion 4 hours after second revision TKA in a patient with a history of several surgical procedures because of periprosthetic infection at a previous hospital. Revascularization was achieved via bypass grafting and amputation was narrowly avoided despite time lag after symptom onset to revascularization. In this case, it was possible that the arterial disease that accompanied the vascular endothelium injury such as pseudoaneurysm had existed since the previous surgery at another hospital and was destroyed by the surgical procedure, which led to the formation of thrombosis and arterial occlusion. Preoperative evaluation of the arterial condition should be considered to avoid acute arterial occlusive disease, especially in patients who had several previous surgical procedures.

  2015, Case reports in orthopedics, 2015, 672164 - 672164, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluation of implant alignment in navigated unicompartmental knee arthroplasty: A comparison of 2D and 3D imaging

  Kazunari Ishida, Akihiko Toda, Nao Shibanuma, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  2015, Acta Orthopaedica Belgica, 81(4) (4), 654 - 661, English, International magazine

  [Refereed]

  Scientific journal


• SDF-1/CXCR4 axis in tie2-Lineage cells including endothelial progenitor cells contributes to bone fracture healing

  Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Ryosuke Kuroda, Tomoya Kuroda, Sang Mo Kwon, Atsuhiko Kawamoto, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Masahiro Kurosaka, Takayuki Asahara

  Jan. 2015, Journal of Bone and Mineral Research, 30(1) (1), 95 - 105, English, International magazine

  [Refereed]

  Scientific journal


• Joint gap assessment with a tensor is useful for the selection of insert thickness in unicompartmental knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Hirotsugu Muratsu, Atsuo Uefuji, Naoki Nakano, Kanto Nagai, Tokio Matsuzaki, Shinya Oka, Kazunari Ishida, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2015, Clinical Biomechanics, 30(1) (1), 95 - 99, English, International magazine

  [Refereed]

  Scientific journal


• 前十字靱帯再建手術後6ヵ月の膝関節伸展筋力健患比の予測

  柴田 洋平, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 上田 雄也, 小野 くみ子, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 3 - 3, Japanese


• スポーツ競技者における膝前十字靱帯再建術後早期の膝伸展筋力回復に影響を及ぼす因子の検討

  西田 京平, 上田 雄也, 荒木 大輔, 松下 雄彦, 松本 知之, 高山 孝治, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 5 - 5, Japanese


• ACL再建術 競技復帰へ向けた取り組みと問題点 スポーツ復帰にむけた再建膝評価

  松下 雄彦, 黒田 良祐, 荒木 大輔, 柴田 洋平, 上田 雄也, 瀧口 耕平, 木田 晃弘, 西田 京平, 井口 貴雄, 松本 知之, 高山 幸治, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 35 - 35, Japanese


• スポーツ競技者における膝前十字靱帯再建術後1年での跳躍動作に影響を及ぼす因子の検討

  上田 雄也, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 柴田 洋平, 小野 くみ子, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  スポーツ傷害フォーラム, Jan. 2015, スポーツ傷害, 20, 4 - 4, Japanese


• Intraoperative platelet-rich plasma does not improve outcomes of total knee arthroplasty

  Masayuki Morishita, Kazunari Ishida, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka, Nobuhiro Tsumura

  Dec. 2014, Journal of Arthroplasty, 29(12) (12), 2337 - 2341, English, International magazine

  [Refereed]

  Scientific journal


• Intra-articular administration of gelatin hydrogels incorporating rapamycin-micelles reduces the development of experimental osteoarthritis in a murine model

  Tokio Matsuzaki, Takehiko Matsushita, Yasuhiko Tabata, Takashi Saito, Tomoyuki Matsumoto, Kanto Nagai, Ryosuke Kuroda, Masahiro Kurosaka

  Dec. 2014, Biomaterials, 35(37) (37), 9904 - 9911, English, International magazine

  [Refereed]

  Scientific journal


• 内側膝蓋大腿靱帯再建手術症例における術後早期の膝関節可動域に影響する因子

  柴田 洋平, 松下 雄彦, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 上田 雄也, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4) (4), S173 - S173, Japanese


• スポーツ競技者における膝前十字靱帯再建術後早期の良好な膝伸展筋力回復に関する要因の検討

  上田 雄也, 荒木 大輔, 松下 雄彦, 瀧口 耕平, 柴田 洋平, 松本 知之, 高山 孝治, 酒井 良忠, 黒坂 昌弘, 黒田 良祐

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4) (4), S211 - S211, Japanese


• Clinical outcomes of medial patellofemoral ligament reconstruction in patients with an increased tibial tuberosity–trochlear groove distance

  Takehiko Matsushita, Ryosuke Kuroda, Shinya Oka, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka

  Sep. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(10) (10), 2438 - 2444, English, International magazine

  [Refereed]

  Scientific journal


• Bilateral medial patellofemoral ligament reconstruction in high-level athletes

  Yuichi Kuroda, Takehiko Matsushita, Tomoyuki Matsumoto, Yohei Kawakami, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(10) (10), 2465 - 2469, English, International magazine

  [Refereed]

  Scientific journal


• Three-dimensional analysis of bone tunnel changes after anatomic double-bundle anterior cruciate ligament reconstruction using multidetector-row computed tomography

  Daisuke Araki, Ryosuke Kuroda, Tomoyuki Matsumoto, Kouki Nagamune, Takehiko Matsushita, Yuichi Hoshino, Shinya Oka, Yuichiro Nishizawa, Masahiro Kurosaka

  Sep. 2014, American Journal of Sports Medicine, 42(9) (9), 2234 - 2241, English, International magazine

  [Refereed]

  Scientific journal


• Simulation of the optimal femoral insertion site in medial patellofemoral ligament reconstruction

  Shinya Oka, Takehiko Matsushita, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Tajimi, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(10) (10), 2364 - 2371, English, International magazine

  [Refereed]

  Scientific journal


• 人工膝関節全置換術における膝蓋大腿関節接触圧の検討 Fixed bearingとMobile bearingTKAの比較

  Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 183, Japanese

  [Refereed]

  Research society


• ACL再建術の中長期成績 膝前十字靱帯(ACL)再建術の中長期成績

  黒田 良祐, 松下 雄彦, 荒木 大輔, 高山 孝治, 松本 知之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2014, 中部日本整形外科災害外科学会雑誌, 57(秋季学会) (秋季学会), 54 - 54, Japanese


• The influence of the tibial slope on intra-operative soft tissue balance in cruciate-retaining and posterior-stabilized total knee arthroplasty

  Shinya Oka, Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(8) (8), 1812 - 1818, English, International magazine

  [Refereed]

  Scientific journal


• Non-anatomical Anterior Cruciate Ligament Remnants Do Not Contribute Dynamic Knee Stability ˜Quantitative Measurement Of The Pivot Shift Test˜

  Kanto Nagai, Ryosuke Kuroda, Daisuke Araki, Yuichiro Nishizawa, Takehiko Matsushita, Yuichi Hoshino, Tomoyuki Matsumoto, Koji Takayama, Kouki Nagamune, Masahiro Kurosaka

  Jul. 2014, Orthopaedic Journal of Sports Medicine, 2

  [Refereed]

  Scientific journal


• Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

  Tokio Matsuzaki, Takehiko Matsushita, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2014, Annals of the Rheumatic Diseases, 73(7) (7), 1397 - 1404, English, International magazine

  [Refereed]

  Scientific journal


• ACL損傷に対する治療の現状と今後の戦略 膝前十字靱帯(ACL)損傷の術前・術後評価法

  黒田 良祐, 松下 雄彦, 星野 祐一, 荒木 大輔, 高山 孝治, 松本 知之, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 98 - 98, Japanese


• MDCTを用いた前十字靱帯解剖学的二重束再建術後骨孔拡大の検討

  荒木 大輔, 黒田 良祐, 松本 知之, 長宗 高樹, 松下 雄彦, 高山 孝治, 西澤 勇一郎, 星野 祐一, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 391 - 391, Japanese


• Early-onset severe neuromatous pain of the infrapatellar branch of the saphenous nerve after total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Isao Fujibayashi, Ryosuke Kuroda, Masahiro Kurosaka

  Jul. 2014, Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 1(3) (3), 102 - 105

  [Refereed]

  Scientific journal


• Age-related differences in anterior cruciate ligament remnant vascular-derived cells

  Atsuo Uefuji, Tomoyuki Matsumoto, Takehiko Matsushita, Takeshi Ueha, Shurong Zhang, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2014, American Journal of Sports Medicine, 42(6) (6), 1478 - 1486, English, International magazine

  [Refereed]

  Scientific journal


• 人工膝関節再々置換術後に膝窩動脈閉塞を認めた1例

  Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  May 2014, 中部日本整形外科災害外科学会雑誌, 57(3号) (3号), 515 - 516, Japanese

  [Refereed]

  Scientific journal


• Reduction of tunnel enlargement with use of autologous ruptured tissue in anterior cruciate ligament reconstruction: A pilot clinical trial

  Tomoyuki Matsumoto, Ryosuke Kuroda, Takehiko Matsushita, Daisuke Araki, Yuichi Hoshino, Kouki Nagamune, Masahiro Kurosaka

  Apr. 2014, Arthroscopy - Journal of Arthroscopic and Related Surgery, 30(4) (4), 468 - 474, English, International magazine

  [Refereed]

  Scientific journal


• Tibial tubercle osteotomy with screw fixation for total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Ryosuke Kuroda, Tomoyuki Matsumoto, Seiji Kubo, Tetsuhiro Iguchi, Takaaki Chin, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Nobuhiro Tsumura

  Apr. 2014, Orthopedics, 37(4) (4), e367-73 - +, English, International magazine

  [Refereed]

  Scientific journal


• No difference between double-high insert and medial-pivot insert in TKA

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Takashi Iwakura, Seiji Kubo, Tetsuhiro Iguchi, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(3) (3), 576 - 580, English, International magazine

  [Refereed]

  Scientific journal


• Evaluation of patellofemoral joint in ADVANCE® Medial-pivot total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Tomoyuki Matsumoto, Yuichi Kuroda, Atsushi Kitagawa, Ryosuke Kuroda, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Nobuhiro Tsumura

  Mar. 2014, International Orthopaedics, 38(3) (3), 509 - 515, English, International magazine

  [Refereed]

  Scientific journal


• Tibial internal rotation is affected by lateral laxity in cruciate-retaining total knee arthroplasty: An intraoperative kinematic study using a navigation system and offset-type tensor

  Tokio Matsuzaki, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Yohei Kawakami, Kazunari Ishida, Shinya Oka, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Knee Surgery, Sports Traumatology, Arthroscopy, 22(3) (3), 615 - 620, English, International magazine

  [Refereed]

  Scientific journal


• Soft tissue balance changes depending on joint distraction force in total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Journal of Arthroplasty, 29(3) (3), 520 - 524, English, International magazine

  [Refereed]

  Scientific journal


• Retrospective comparison of three thromboprophylaxis agents, edoxaban, fondaparinux, and enoxaparin, for preventing venous thromboembolism in total knee arthroplasty

  Hiroshi Sasaki, Kazunari Ishida, Nao Shibanuma, Katsumasa Tei, Hiroomi Tateishi, Akihiko Toda, Yukiko Yamashiro, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, International Orthopaedics, 38(3) (3), 525 - 529, English, International magazine

  [Refereed]

  Scientific journal


• Soft-tissue balancing in total knee arthroplasty: Cruciate-retaining versus posterior-stabilised, and measured-resection versus gap technique

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Yohei Kawakami, Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Toshihiro Akisue, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, International Orthopaedics, 38(3) (3), 531 - 537, English, International magazine

  [Refereed]

  Scientific journal


• Satisfactory results at 8years mean follow-up after ADVANCE® medial-pivot total knee arthroplasty

  Nobuaki Chinzei, Kazunari Ishida, Nobuhiro Tsumura, Tomoyuki Matsumoto, Atsushi Kitagawa, Tetsuhiro Iguchi, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Knee, 21(2) (2), 387 - 390, English, International magazine

  [Refereed]

  Scientific journal


• Matching articular surfaces of selected donor and recipient sites for cylindrical osteochondral grafts of the femur: Quantitative evaluation using a 3-dimensional laser scanner

  Yuichiro Nishizawa, Tomoyuki Matsumoto, Daisuke Araki, Kouki Nagamune, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2014, American Journal of Sports Medicine, 42(3) (3), 658 - 664, English, International magazine

  [Refereed]

  Scientific journal


• 3D-MDCTを用いた前十字靱帯再建術後骨孔拡大の検討 解剖学的一重束再建術と二重束再建術との比較

  荒木 大輔, 黒田 良祐, 松本 知之, 長宗 高樹, 松下 雄彦, 高山 孝治, 西澤 勇一郎, 星野 祐一, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S1001 - S1001, Japanese


• A development of force distributionmeasurement system with high resolution for total knee arthroplasty

  Mohd Hanafi Mat Som, Kouki Nagamune, Takashi Kamiya, Shogo Kawaguchi, Koji Takayama, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2014, Journal of Advanced Computational Intelligence and Intelligent Informatics, 18(2) (2), 213 - 220

  Scientific journal


• Local transplantation of granulocyte colony stimulating factor-mobilized CD34⁺ cells for patients with femoral and tibial nonunion: Pilot clinical trial

  Ryosuke Kuroda, Tomoyuki Matsumoto, Takahiro Niikura, Yohei Kawakami, Tomoaki Fukui, Sang Yang Lee, Yutaka Mifune, Shin Kawamata, Masanori Fukushima, Takayuki Asahara, Atsuhiko Kawamoto, Masahiro Kurosaka

  2014, Stem Cells Translational Medicine, 3(1) (1), 128 - 134, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of Force Concentration in Varus and Valgus Motion in Total Knee Arthroplasty

  Sahashi Katsuya, Kawaguchi Shogo, Som Mohd Hanafi Mat, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Total knee arthroplasty is a surgery to replace original injured knee to a prosthesis. In this surgery, it is important to select a proper size of the prosthesis as fitting to the patients. This selection strongly depends on the experience and feeling of surgeon. This study aims to develop a system which can support to select the proper size. Therefore, this study examines an effect of varus and valgus motion to the tibial component of the prosthesis by using the developed system. In general, when the force concentration happens on the tibial component, it results in wear of the prosthesis after surgery and can shorten lifetime of the prosthesis. This system can contribute to avoid these problems.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2014, Proceedings of the Fuzzy System Symposium, 30, 494 - 497, Japanese


• 前十字靱帯再建手術症例における筋力回復の経時的変化

  柴田 洋平, 黒田 良祐, 荒木 大輔, 木田 晃弘, 瀧口 耕平, 小野 くみ子, 西澤 勇一郎, 松下 雄彦, 松本 知之, 酒井 良忠, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2014, スポーツ傷害, 19, 46 - 46, Japanese


• Combined ACL and peripheral instability: The Eastern experience

  Ryosuke Kuroda, Takehiko Matsushita, Daisuke Araki, Yuichiro Nishizawa, Tomoyuki Matsumoto, Masahiro Kurosaka

  Springer-Verlag Milan, Jan. 2014, Knee Ligament Injuries: Extraarticular Surgical Techniques, 113 - 120, English

  [Refereed]

  In book


• An evaluation of bimodality on quantitative measurement system for lachman test using force sensor

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Daisuke Araki, Yuichi Hoshino, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2014, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, 2014-January(January) (January), 3936 - 3940, English

  [Refereed]

  International conference proceedings


• Influence of intra-operative parameters on postoperative early recovery of active knee flexion in posterior-stabilized total knee arthroplasty

  Kanto Nagai, Hirotsugu Muratsu, Tomoyuki Matsumoto, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Nov. 2013, International Orthopaedics, 37(11) (11), 2153 - 2157, English, International magazine

  [Refereed]

  Scientific journal


• Different pattern in gap balancing between the cruciate-retaining and posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Kazunari Ishida, Yohei Kawakami, Shinya Oka, Tokio Matsuzaki, Yuichi Kuroda, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2013, Knee Surgery, Sports Traumatology, Arthroscopy, 21(10) (10), 2338 - 2345, English, International magazine

  [Refereed]

  Scientific journal


• Long-term subjective outcomes of computer-assisted total knee arthroplasty

  Naoki Nakano, Tomoyuki Matsumoto, Kazunari Ishida, Nobuhiro Tsumura, Ryosuke Kuroda, Masahiro Kurosaka

  Oct. 2013, International Orthopaedics, 37(10) (10), 1911 - 1915, English, International magazine

  [Refereed]

  Scientific journal


• 当院での前十字靱帯再建手術症例における筋力回復の経時的変化

  柴田 洋平, 黒田 良祐, 荒木 大輔, 瀧口 耕平, 西澤 勇一郎, 松下 雄彦, 松本 知之, 酒井 良忠, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4) (4), S144 - S144, Japanese


• A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization

  Yohei Kawakami, Masaaki Li, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Michio Asahi, Masahiro Kurosaka, Takayuki Asahara

  Sep. 2013, Laboratory Investigation, 93(9) (9), 1036 - 1053, English, International magazine

  [Refereed]

  Scientific journal


• An analysis of surface profile for cylindrical osteochondral grafts of the knee quantitative evaluation using a three-dimensional laser scanner

  Daisuke Araki, Ryosuke Kuroda, Tomoyuki Matsumoto, Kouki Nagamune, Takehiko Matsushita, Seiji Kubo, Yasunari Oniki, Masahiro Kurosaka

  Aug. 2013, Knee Surgery, Sports Traumatology, Arthroscopy, 21(8) (8), 1794 - 1800, English, International magazine

  [Refereed]

  Scientific journal


• Tendon graft revitalization using adult anterior cruciate ligament (ACL)-derived CD34+ cell sheets for ACL reconstruction

  Yutaka Mifune, Tomoyuki Matsumoto, Koji Takayama, Satoshi Terada, Naosumi Sekiya, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Jul. 2013, Biomaterials, 34(22) (22), 5476 - 5487, English, International magazine

  [Refereed]

  Scientific journal


• Analysis of circulating mesenchymal progenitor cells in arterial and venous blood after fracture

  Takashi Iwakura, Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Keisuke Oe, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2013, Journal of Tissue Engineering and Regenerative Medicine, 7(6) (6), 501 - 504, English, International magazine

  [Refereed]

  Scientific journal


• Differences in knee kinematics between awake and anesthetized patients during the Lachman and pivot-shift Tests for anterior cruciate ligament deficiency

  Takehiko Matsushita, Shinya Oka, Kouki Nagamune, Tomoyuki Matsumoto, Yuichiro Nishizawa, Yuichi Hoshino, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Ltd, Jun. 2013, Orthopaedic Journal of Sports Medicine, 1(1) (1), 1 - 6, English

  [Refereed]

  Scientific journal


• Biomechanical analysis of the knee with partial anterior cruciate ligament disruption: Quantitative evaluation using an electromagnetic measurement system

  Daisuke Araki, Ryosuke Kuroda, Takehiko Matsushita, Tomoyuki Matsumoto, Seiji Kubo, Kouki Nagamune, Masahiro Kurosaka

  Jun. 2013, Arthroscopy - Journal of Arthroscopic and Related Surgery, 29(6) (6), 1053 - 1062, English, International magazine

  [Refereed]

  Scientific journal


• 多血小板血漿(PRP)を用いたTKA施行患者の術後評価

  石田 一成, 森下 雅之, 柴沼 均, 鎮西 伸顕, 北川 篤, 松本 知之, 黒田 良祐, 黒坂 昌弘, 津村 暢宏

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 561 - 561, Japanese


• 人工膝関節全置換術後感染例の治療成績 深部感染50症例の検討

  松本 知之, 石田 一成, 津村 暢宏, 村津 裕嗣, 飛田 祐一, 平中 崇文, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 460 - 460, Japanese


• Local administration of low-dose simvastatin-conjugated gelatin hydrogel for tendon-bone healing in anterior cruciate ligament reconstruction

  Shinya Oka, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Hiroshi Sasaki, Yuichiro Nishizawa, Tokio Matsuzaki, Takashi Saito, Kotaro Nishida, Yasuhiko Tabata, Masahiro Kurosaka, Ryosuke Kuroda

  May 2013, Tissue Engineering - Part A, 19(9-10) (9-10), 1233 - 1243, English, International magazine

  [Refereed]

  Scientific journal


• The use of blood vessel-derived stem cells for meniscal regeneration and repair

  Aki Osawa, Christopher D. Harner, Burhan Gharaibeh, Tomoyuki Matsumoto, Yutaka Mifune, Sebastian Kopf, Sheila J.M. Ingham, Verena Schreiber, Arvydas Usas, Johnny Huard

  May 2013, Medicine and Science in Sports and Exercise, 45(5) (5), 813 - 823, English, International magazine

  [Refereed]

  Scientific journal


• Kinematic factors affecting postoperative knee flexion after cruciate-retaining total knee arthroplasty

  Tokio Matsuzaki, Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Yohei Kawakami, Kazunari Ishida, Shinya Oka, Ryosuke Kuroda, Masahiro Kurosaka

  May 2013, International Orthopaedics, 37(5) (5), 803 - 808, English, International magazine

  [Refereed]

  Scientific journal


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法 臨床試験の報告

  新倉 隆宏, 黒田 良祐, 松本 知之, 李 相亮, 川上 洋平, 黒坂 昌弘

  (一社)日本骨折治療学会, May 2013, 骨折, 35(2) (2), 465 - 468, Japanese


• The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

  Takehiko Matsushita, Hiroshi Sasaki, Koji Takayama, Kazunari Ishida, Tomoyuki Matsumoto, Seiji Kubo, Tokio Matsuzaki, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2013, Journal of Orthopaedic Research, 31(4) (4), 531 - 537, English, International magazine

  [Refereed]

  Scientific journal


• Medial patellofemoral ligament reconstruction with lateral soft tissue release in adult patients with habitual patellar dislocation

  Takehiko Matsushita, Ryosuke Kuroda, Daisuke Araki, Seiji Kubo, Tomoyuki Matsumoto, Masahiro Kurosaka

  Mar. 2013, Knee Surgery, Sports Traumatology, Arthroscopy, 21(3) (3), 726 - 730, English, International magazine

  [Refereed]

  Scientific journal


• The influence of patella height on soft tissue balance in cruciate-retaining and posterior-stabilised total knee arthroplasty.

  Yuichiro Nishizawa, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Shinya Oka, Kazunari Ishida, Tokio Matsuzaki, Kotaro Nishida, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Mar. 2013, International orthopaedics, 37(3) (3), 421 - 425, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic advantage in selective ligament augmentation for partial tears of the anterior cruciate ligament: Results in an animal model

  Yutaka Mifune, Shusuke Ota, Koji Takayama, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Feb. 2013, American Journal of Sports Medicine, 41(2) (2), 365 - 373, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation

  Yutaka Mifune, Tomoyuki Matsumoto, Satoshi Murasawa, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Tomoya Kuroda, Tomoaki Fukui, Yohei Kawakami, Masahiro Kurosaka, Takayuki Asahara

  2013, Cell Transplantation, 22(7) (7), 1201 - 1211, English, International magazine

  [Refereed]

  Scientific journal


• Intra-operative joint gap kinematics in unicompartmental knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  Jan. 2013, Clinical Biomechanics, 28(1) (1), 29 - 33, English, International magazine

  [Refereed]

  Scientific journal


• Robotic tensor device for optimal soft tissue balance in TKA

  Jun Okamoto, Tomoyuki Matsumoto, Hirotsugu Muratsu, Masahiro Kurosaka, Yoshihiro Muragaki, Hiroshi Iseki

  2013, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2013, 6695 - 6698, English, International magazine

  [Refereed]

  International conference proceedings


• A Development of Force Distribution Measurement Systemin Total Knee Arthroplasty and reporting of the PS type measurement

  Kamiya Takashi, Kawaguchi Shogo, Som Mohd Hanafi Mat, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Currently, the number of Total Knee Arthroplasty (TKA) in Japan is 70,000. Because it is easy to expect increasing the number due to super-aging society, the clinical outcome of TKA surgery has been important. The surgery requires proper soft tissue balance to avoid shortening fatigue life of prosthesis. Thus, a measurement system of force concentration about contacting region between femur component and polyethylene insert contributes to prolong the prosthesis. This study examined the force concentration by using our developed measurement system. This study performed two experiment consists of physical and simulated experiment. As a result, our developed system could localize the force concentration point. A future work is to apply this measurement system to the cadaveric knee.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2013, Proceedings of the Fuzzy System Symposium, 29, 54 - 54, Japanese


• Navigation-assisted total knee arthoroplasty for osteoarthritis with extra-articular deformity

  TANI Izumi

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2013, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 56(6) (6), 1347 - 1348, Japanese


• 両側内側膝蓋大腿靱帯(MPFL)再建術を施行したハイレベルスポーツ選手の2例

  黒田 雄一, 黒田 良祐, 松下 雄彦, 松本 知之, 川上 洋平, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2013, スポーツ傷害, 18, 43 - 43, Japanese


• Endothelial progenitor cells, lnk and bone fracture healing

  Tomoyuki Matsumoto, Takayuki Asahara

  Jan. 2013, Stem Cells and Bone Tissue, 180 - 199

  In book


• An evaluation method of force concentration in PS type of total knee arthroplasty with force distribution measurement system

  Takashi Kamiya, Shogo Kawaguchi, Mohd Hanafi Mat Som, Kouki Nagamune, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  2013, Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013, 2561 - 2564, English

  [Refereed]

  International conference proceedings


• An early development of force distribution sensor using pressure-sensitive conductive rubber for soft tissue balance in total knee arthroplasty

  Mohd Hanafi Mat Som, Kouki Nagamune, Takashi Kamiya, Shogo Kawaguchi, Tomoyuki Matsumoto, Ryosuke Kuroda, Masahiro Kurosaka

  2013, Proceedings - 2013 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2013, 2556 - 2560, English

  [Refereed]

  International conference proceedings


• The effect of platelet-rich plasma on the regenerative therapy of muscle derived stem cells for articular cartilage repair

  Y. Mifune, T. Matsumoto, K. Takayama, S. Ota, H. Li, L. B. Meszaros, A. Usas, K. Nagamune, B. Gharaibeh, F. H. Fu, J. Huard

  Jan. 2013, Osteoarthritis and Cartilage, 21(1) (1), 175 - 185, English

  [Refereed]

  Scientific journal


• Study of anatomical landmark sampling error effect on motion measurement reproducibility for orthopaedic physical examination assisting system

  Jun Okamoto, Yu Kumasaka, Kazuya Kawamura, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Masahiro Kurosaka, Masakatsu G. Fujie

  2013, Journal of Advanced Mechanical Design, Systems and Manufacturing, 7(2) (2), 125 - 139, English

  [Refereed]

  Scientific journal


• Novel image-matching software for postoperative evaluation after TKA.

  Katsumasa Tei, Kazunari Ishida, Tomoyuki Matsumoto, Seiji Kubo, Hiroshi Sasaki, Nao Shibanuma, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Dec. 2012, Orthopedics, 35(12) (12), e1711-5 - E1715, English, International magazine

  [Refereed]

  Scientific journal


• Multiple huge subchondral cysts associated with pseudogout in the bilateral knees: A case report and review of the literatures

  Masaya Minoda, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Koji Takayama, Yukiko Morinaga, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, Journal of Orthopaedic Science, 17(6) (6), 817 - 821, English, Domestic magazine

  [Refereed]

  Scientific journal


• The influence of patella height on intra-operative soft tissue balance in posterior-stabilized total knee arthroplasty

  Hiroshi Sasaki, Seiji Kubo, Tomoyuki Matsumoto, Hirotsugu Muratsu, Takehiko Matsushita, Kazunari Ishida, Koji Takayama, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(11) (11), 2191 - 2196, English, International magazine

  [Refereed]

  Scientific journal


• Osteochondral autograft transplantation for juvenile osteochondritis dissecans of the knee: A series of twelve cases

  Ken Sasaki, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Kazunari Ishida, Katsumasa Tei, Toshihiro Akisue, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2012, International Orthopaedics, 36(11) (11), 2243 - 2248, English, International magazine

  [Refereed]

  Scientific journal


• Intraoperative Soft Tissue Balance Reflects Minimum 5-Year Midterm Outcomes in Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2012, Journal of Arthroplasty, 27(9) (9), 1723 - 1730, English, International magazine

  [Refereed]

  Scientific journal


• In vivo comparisons of patellofemoral kinematics before and after ADVANCE^® Medial-Pivot total knee arthroplasty

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Nobuaki Chinzei, Atsushi Kitagawa, Seiji Kubo, Takaaki Chin, Tetsuhiro Iguchi, Toshihiro Akisue, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2012, International Orthopaedics, 36(10) (10), 2073 - 2077, English, International magazine

  [Refereed]

  International conference proceedings


• MPFL再建術における至適固定部位導出シミュレーション

  Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  日本臨床バイオメカニクス学会, Oct. 2012, 臨床バイオメカニクス, 33, 179 - 184, Japanese

  [Refereed]

  Scientific journal


• 両側高位脛骨骨切り術を施行しラグビーに復帰した高齢者の1例

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  Oct. 2012, 日本臨床スポーツ医学会誌, 20(4号) (4号), S183, Japanese

  [Refereed]

  Research society


• Spontaneous recurrent hemarthrosis of the knee joint in the elderly: A report of two cases

  Kanto Nagai, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Koji Takayama, Daisuke Araki, Hiroshi Sasaki, Shinya Oka, Toshihiro Akisue, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2012, Journal of Orthopaedic Science, 17(5) (5), 649 - 653, English, Domestic magazine

  [Refereed]

  Scientific journal


• 当科で施行した膝前十字靱帯再々建術の検討

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 127, Japanese

  [Refereed]

  Research society


• 両側血友病性膝関節症に対して全人工膝関節置換術を施行した1例

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Matsushita Takehiko, Nishida Kotaro, Kurosaka Masahiro

  Sep. 2012, 関節外科, 31(9号) (9号), 1045 - 1051, Japanese

  [Refereed]

  Scientific journal


• The accuracy of bone tunnel position using fluoroscopic-based navigation system in anterior cruciate ligament reconstruction

  Yohei Kawakami, Takafumi Hiranaka, Tomoyuki Matsumoto, Yuichi Hida, Tomoaki Fukui, Harunobu Uemoto, Minoru Doita, Mitsuo Tsuji, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(8) (8), 1503 - 1510, English, International magazine

  [Refereed]

  Scientific journal


• Backout of the helical blade of proximal femoral nail antirotation and accompanying fracture nonunion

  Takahiro Niikura, Sang Yang Lee, Tomoyuki Matsumoto, Tomoaki Fukui, Yohei Kawakami, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2012, Orthopedics, 35(8) (8), e1264-6 - E1266, English, International magazine

  [Refereed]

  Scientific journal


• 軟骨細胞特異的Sirt1ノックアウトマウスにおける変形性関節症モデルを用いた解析

  Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1272, Japanese

  [Refereed]

  Research society


• 軟骨再生の今 軟骨変性に対する長寿因子SIRT1を介した抑制制御機構

  Matsushita Takehiko, Kuroda Ryosuke, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Aug. 2012, 日本整形外科学会雑誌, 86(8号) (8号), S1248, Japanese

  Research society


• An emerging cell-based strategy in orthopaedics: Endothelial progenitor cells

  Kivanc Atesok, Tomoyuki Matsumoto, Jon Karlsson, Takayuki Asahara, Anthony Atala, M. Nedim Doral, Rene Verdonk, Ru Li, Emil Schemitsch

  Jul. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(7) (7), 1366 - 1377, English, International magazine

  [Refereed]

  Scientific journal


• The influence of patellar position on soft tissue balance in minimal incision total knee arthroplasty

  Shinya Oka, Hirotsugu Muratsu, Tomoyuki Matsumoto, Seiji Kubo, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(6) (6), 1064 - 1068, English, International magazine

  [Refereed]

  Scientific journal


• Autophagy modulates osteoarthritis-related gene expression in human chondrocytes

  Hiroshi Sasaki, Koji Takayama, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Norifumi Fujita, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2012, Arthritis and Rheumatism, 64(6) (6), 1920 - 1928, English, International magazine

  [Refereed]

  Scientific journal


• Acceleration of tendon-bone healing of anterior cruciate ligament graft using autologous ruptured tissue

  Tomoyuki Matsumoto, Seiji Kubo, Ken Sasaki, Yohei Kawakami, Shinya Oka, Hiroshi Sasaki, Koji Takayama, Katsumasa Tei, Takehiko Matsushita, Yutaka Mifune, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2012, American Journal of Sports Medicine, 40(6) (6), 1296 - 1302, English, International magazine

  [Refereed]

  Scientific journal


• 当科における骨端線閉鎖前の患者に対するRetroDrillを用いた前十字靱帯再建術とその術後短期成績

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 401, Japanese

  [Refereed]

  Research society


• 人工膝関節単顆置換術における術中gap kinematics評価 CR型TKA、PS型TKAとの比較

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2012, JOSKAS, 37(4号) (4号), 347, Japanese

  [Refereed]

  Research society


• MPFL再建術時の大腿骨側再建位置シミュレーション

  Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 226, Japanese

  Research society


• CR-TKAにおける術中軟部組織バランスと術後アウトカムの関係

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2012, JOSKAS, 37(4号) (4号), 48, Japanese

  Research society


• ACL再再建術 術式の工夫と成績 ACL再再建術 術式の工夫と成績

  Kurosaka Masahiro, Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki

  Jun. 2012, JOSKAS, 37(4号) (4号), 19, Japanese

  [Invited]

  Research society


• ACL再建術後のスポーツ復帰 現状と課題 ACL再建術後のスポーツ復帰 動作解析からの評価

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 200, Japanese

  [Refereed][Invited]

  Research society


• ACL augmentationと解剖学的二重束ACL再建術の術前後不安定性の検討

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Jun. 2012, JOSKAS, 37(4号) (4号), 75, Japanese

  [Refereed]

  Research society


• Soft tissue balance using the tibia first gap technique with navigation system in cruciate-retaining total knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Hirosi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  May 2012, International Orthopaedics, 36(5) (5), 975 - 980, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic effect of local administration of low-dose simvastatin- conjugated gelatin hydrogel for fracture healing

  Tomoaki Fukui, Masaaki Ii, Taro Shoji, Tomoyuki Matsumoto, Yutaka Mifune, Yohei Kawakami, Hiroshi Akimaru, Atsuhiko Kawamoto, Tomoya Kuroda, Takashi Saito, Yasuhiko Tabata, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  May 2012, Journal of Bone and Mineral Research, 27(5) (5), 1118 - 1131, English, International magazine

  [Refereed]

  Scientific journal


• An analysis of bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein 2 from a biodegradable sponge composed of gelatin and β-tricalcium phosphate

  N. Fujita, T. Matsushita, K. Ishida, K. Sasaki, S. Kubo, T. Matsumoto, M. Kurosaka, Y. Tabata, R. Kuroda

  Apr. 2012, Journal of Tissue Engineering and Regenerative Medicine, 6(4) (4), 291 - 298, English

  [Refereed]

  Scientific journal


• Isolation and characterization of human anterior cruciate ligament-derived vascular stem cells

  Tomoyuki Matsumoto, Sheila M. Ingham, Yutaka Mifune, Aki Osawa, Alison Logar, Arvydas Usas, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  Apr. 2012, Stem Cells and Development, 21(6) (6), 859 - 872, English, International magazine

  [Refereed]

  Scientific journal


• Role of angiogenesis after muscle derived stem cell transplantation in injured medial collateral ligament

  Makoto Nishimori, Tomoyuki Matsumoto, Shusuke Ota, Sebastian Kopf, Yutaka Mifune, Christopher Harner, Mitsuo Ochi, Freddie H. Fu, Johnny Huard

  Apr. 2012, Journal of Orthopaedic Research, 30(4) (4), 627 - 633, English, International magazine

  [Refereed]

  Scientific journal


• Quantitative measurement of the pivot shift, reliability, and clinical applications

  Ryosuke Kuroda, Yuichi Hoshino, Daisuke Araki, Yuichiro Nishizawa, Kouki Nagamune, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka

  Apr. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(4) (4), 686 - 691, English, International magazine

  [Refereed]

  Scientific journal


• Autogenous osteochondral graft transplantation for steroid-induced osteonecrosis of the femoral condyle: A report of three young patients

  Norifumi Fujita, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Kazunari Ishida, Yuichi Hoshino, Koji Nishimoto, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2012, Sports Medicine, Arthroscopy, Rehabilitation, Therapy and Technology, 4(1) (1), 13 - 13, English, International magazine

  [Refereed]

  Scientific journal


• Influence of intra-operative joint gaps on post-operative flexion angle in posterior cruciate-retaining total knee arthroplasty

  Koji Takayama, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Kazunari Ishida, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(3) (3), 532 - 537, English, International magazine

  [Refereed]

  Scientific journal


• 人工膝関節全置換術における術中軟部組織バランスの中期臨床成績に及ぼす影響 術中計測値と術後5年での膝安定性の相関

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S708, Japanese

  Research society


• 診断に難渋した膝関節滑膜性骨軟骨腫症の1例

  Kubo Seiji, Matsumoto Tomoyuki, Matsushita Takehiko, Kuroda Ryosuke, Kawamoto Teruya, Kurosaka Masahiro

  (一社)中部日本整形外科災害外科学会, Mar. 2012, 中部日本整形外科災害外科学会雑誌, 55(2号) (2号), 436 - 437, Japanese

  [Refereed]

  Research society


• Combined osteochondral fracture of the posterolateral tibial plateau and Segond fracture with anterior cruciate ligament injury in a skeletally immature patient

  Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Akio Matsumoto, Masahiro Kurosaka, Ryosuke Kuroda

  Feb. 2012, Knee Surgery, Sports Traumatology, Arthroscopy, 20(2) (2), 252 - 255, English, International magazine

  [Refereed]

  Scientific journal


• 脛骨後方傾斜が術中軟部組織バランスに及ぼす影響 CR型、PS型TKAでの比較

  Matsumoto Tomoyuki, Kubo Seiji, Matsushita Takehiko, Kuroda Ryosuke, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S63, Japanese

  Research society


• 膝前十字靱帯不全膝(機能不全膝)の回旋不安定性の定量的評価方法の検討

  Kuroda Ryosuke, Nagamune Kouki, Matsumoto Tomoyuki, Matsushita Takehiko, Kubo Seiji, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S56, Japanese

  Research society


• 膝前十字靱帯再建術の現状と展開 膝前十字靱帯再建術における不安定性の客観的評価

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S219, Japanese

  [Refereed]

  Research society


• 前十字靱帯損傷に対するpivot shift testの検者間における同様性と相違

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Nagamune Kouki, Kurosaka Masahiro

  Feb. 2012, 日本整形外科学会雑誌, 86(2号) (2号), S56, Japanese

  Research society


• Local transplantation of granulocyte colony-stimulating factor-mobilized human peripheral blood mononuclear cells for unhealing bone fractures

  Tomoaki Fukui, Tomoyuki Matsumoto, Yutaka Mifune, Taro Shoji, Tomoya Kuroda, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Shin Kawamata, Masahiro Kurosaka, Takayuki Asahara, Ryosuke Kuroda

  2012, Cell Transplantation, 21(4) (4), 707 - 721, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic potential of anterior cruciate ligament-derived stem cells for anterior cruciate ligament reconstruction

  Yutaka Mifune, Tomoyuki Matsumoto, Shusuke Ota, Makoto Nishimori, Arvydas Usas, Sebastian Kopf, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H. Fu, Johnny Huard

  2012, Cell Transplantation, 21(8) (8), 1651 - 1665, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of ex vivo expanded bone marrow-derived CD34-positive cells accelerates fracture healing.

  Yohei Kawakami, Masaaki Ii, Cantas Alev, Atsuhiko Kawamoto, Tomoyuki Matsumoto, Ryosuke Kuroda, Taro Shoji, Tomoaki Fukui, Haruchika Masuda, Hiroshi Akimaru, Yutaka Mifune, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Masahiro Kurosaka, Takayuki Asahara

  2012, Cell transplantation, 21(12) (12), 2689 - 2709, English, International magazine

  [Refereed]

  Scientific journal


• A Development of Force Distribution Measurement System in Total Knee Arthroplasty and Its Fundamental Results toward Clinical Examination

  Kamiya Takashi, Kawaguchi Shogo, Nagamune Kouki, Matsumoto Tomoyuki, matsushita takehiko, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Recently, the number of total knee arthroplasty (TKA) has been more than 0.7 million with the aging of population in Japan. The number has been more than double in comparing with 10 years ago. Although it is well known that the soft tissue balance is important for the TKA, there is a problem that it depends much on past experiences of an examiner in clinical situation. Thus, a non-expert doctor makes deviation of the balance due to insufficient experiences. Then, we have been developing a system could provide an objective criterion to reduce the deviation. This study reports a force distribution by using a pressure sensor in case of 20 kgF loading which is a value in real situation. The results show loading movement with force distribution in extention and 90 degree flexion. As a result, the force distribution should be more similar to clinical situation. As a future work, it is to improve the measurement precision, and to use in clinical examination.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 342 - 345, Japanese


• Angle Estimation of Instrument for Mosaicplasty by using Knowledge of Force Distribution

  Nishino Satoshi, Toyoshima Takayasu, Nagamune Kouki, Hoshino Yuichi, Matsumoto Tomoyuki, Matsushita Takehiko, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mosaicplasty is one of the surgeries for knee cartilage damage. It transplants the bone autograft with the cartilage to the injured area. In this surgery, it is important to harvest the cartilage graft vertically and transplant it vertically by using a harvester for preventing area around transplant from discontinuous of the cartilage surface. This study set the goal to develop a system to estimate the pose of harvester against the articular surface in considering with a force distribution measured by a force sensor. The proposed method measures a force distribution on the cartilage surface by using eight force sensors which are attached to the front edge of the harvestor of the surfical instrument. It estimates the angle between the articular surface and harvester based on the force distribution. The experiment used a portable force tester for loading, and estimated the angle of the harvester. The result shows the maximum of the angle estimation error was 8 degrees. The experiment of angle estimation performed multiple times, it was confirmed reproducibility. As a future work, angle of estimation is displayed in real time.

  Japan Society for Fuzzy Theory and Intelligent Informatics, 2012, Proceedings of the Fuzzy System Symposium, 28, 362 - 367, Japanese


• Challenge of normality evaluation by using micro-size tension measurement device in anterior cruciate ligament reconstruction

  Shogo Kawaguchi, Kouki Nagamune, Yuichiro Nishizawa, Yuichi Hoshino, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, 2605 - 2609, English

  [Refereed]

  International conference proceedings


• A development of force distribution measurement system in total knee arthroplasty and with high resolution

  Takashi Kamiya, Shogo Kawaguchi, Mohd Hanafi, Mat Som, Kouki Nagamune, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2012, 6th International Conference on Soft Computing and Intelligent Systems, and 13th International Symposium on Advanced Intelligence Systems, SCIS/ISIS 2012, 785 - 788, English

  [Refereed]

  International conference proceedings


• A development of navigation system with image segmentation in mosaicplasty of the knee

  Takayasu Toyoshima, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, IEEE International Conference on Fuzzy Systems, English

  [Refereed]

  International conference proceedings


• An automated calibration by using fuzzy control for a measurement system of Lachman test

  Shogo Kawaguchi, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, IEEE International Conference on Fuzzy Systems, English

  [Refereed]

  International conference proceedings


• A development of surgery instrument pose support system for mosaicplasty by using force distribution

  Satoshi Nishino, Takayasu Toyoshima, Kouki Nagamune, Yuichi Hoshino, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2012, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, 3269 - 3274, English

  [Refereed]

  International conference proceedings


• 巨大遊離骨軟骨片を伴った離断性骨軟骨炎に対して遊離骨軟骨片骨固定術と骨軟骨柱移植術を併用した2例

  Kuroda Ryosuke, Matsushita Takehiko, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jan. 2012, スポーツ傷害, 17, 13, Japanese

  [Refereed]

  Research society


• The Influence of Preoperative Deformity on Intraoperative Soft Tissue Balance in Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Dec. 2011, Journal of Arthroplasty, 26(8) (8), 1291 - 1298, English, International magazine

  [Refereed]

  Scientific journal


• Identification and characterization of chondrogenic progenitor cells in the fascia of postnatal skeletal muscle

  Guangheng Li, Bo Zheng, Laura B. Meszaros, Joseph B. Vella, Arvydas Usas, Tomoyuki Matsumoto, Johnny Huard

  Dec. 2011, Journal of Molecular Cell Biology, 3(6) (6), 369 - 377, English, International magazine

  [Refereed]

  Scientific journal


• Differing prosthetic alignment and femoral component sizing between 2 computer-assisted CT-free navigation systems in TKA

  Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Nobuhiro Tsumura, Kazunari Ishida, Takehiko Matsushita, Koji Takayama, Hiroshi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Dec. 2011, Orthopedics, 34(12) (12), e860-5 - 952, English, International magazine

  [Refereed]

  Scientific journal


• Orthopaedic Physical Examination Assisting System for Improvement of Accuracy and Reproducibility of Knee Laxity Diagnosis

  Okamoto, J, Kumasaka, Y, Kawamura, K, Matsumoto, T, Kubo, S, Muratsu, H, Kurosaka, M, Fujie, M.G

  In this study, to improve accuracy and reproducibility of knee laxity diagnosis, Orthopaedic physical examination assisting system was developed. The system enables the surgeon to monitor the force vector added by himself and the posture of the knee in real-time. The advantage of the developed system is to quantify the normal orthopaedic physical examination, without any modification, which is accustomed to general orthopaedic surgeons. The force vector added to the shank by a surgeon is measured with 3 axis force sensor and 6DOF magnetic tracker FASTRAK, and 6DOF knee joint motion of the patient is measured with two FASTRAK receivers which are attached on its thigh and shank. In this system, to describe the 6DOF knee motion, Femoral and tibial coordinate systems are defined with bony landmark which is easily palpated and are registered to the thigh or shank receiver coordinate system by homogeneous transformation matrix which is acquired by the special stylus. To evaluate the effectiveness of the system, the posterior drawer test with the system was done by 5 young healthy people. The evaluation parameters were knee posture, load magnitude and load position during the experiment. The result showed examination accuracy was significantly improved in all evaluation parameters.

  The Japan Society of Mechanical Engineers, Dec. 2011, Journal of Advanced Mechanical Design, Systems, and Manufacturing, 5(4) (4), 358 - 371, English

  [Refereed]

  Scientific journal


• Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty

  Kazunari Ishida, Nobuhiro Tsumura, Atsushi Kitagawa, Sayaka Hamamura, Koji Fukuda, Yoshihiro Dogaki, Seiji Kubo, Tomoyuki Matsumoto, Takehiko Matsushita, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2011, International Orthopaedics, 35(11) (11), 1639 - 1645, English, International magazine

  [Refereed]

  Scientific journal


• 【人工膝関節のデザインとバイオメカニクス】 人工膝関節の三次元解析 術中軟部組織バランスがTKA術後キネマティクスに及ぼす影響

  Kubo Seiji, Matsumoto Tomoyuki, Kuroda Ryosuke

  Oct. 2011, 関節外科, 30巻, 10月増刊, pp. 112-115, Japanese

  [Refereed]

  Scientific journal


• 変形性膝関節症の介入研究の短期成績 踵の衝撃吸収性に優れた靴の変形性膝関節症に対する効果

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Oct. 2011, 日本整形外科学会雑誌, 85巻, 10号, pp. 755-760, Japanese

  [Refereed]

  Scientific journal


• PLGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors

  Hiroto Iwasaki, Atsuhiko Kawamoto, Marc Tjwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Tomoyuki Matsumoto, Shigefumi Suehiro, Peter Carmeliet, Takayuki Asahara

  Sep. 2011, PLoS ONE, 6(9) (9), e24872, English, International magazine

  [Refereed]

  Scientific journal


• Soft Tissue Tension in Cruciate-Retaining and Posterior-Stabilized Total Knee Arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Takehiko Matsushita, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2011, Journal of Arthroplasty, 26(5) (5), 788 - 795, English, International magazine

  [Refereed]

  Scientific journal


• The double ACL sign: An unusual bucket-handle tear of medial meniscus

  Koji Takayama, Takehiko Matsushita, Tomoyuki Matsumoto, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2011, Knee Surgery, Sports Traumatology, Arthroscopy, 19(8) (8), 1343 - 1346, English, International magazine

  [Refereed]

  Scientific journal


• DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis

  S. Hayashi, T. Nishiyama, Y. Miura, T. Fujishiro, N. Kanzaki, S. Hashimoto, T. Matsumoto, M. Kurosaka, R. Kuroda

  Jul. 2011, Osteoarthritis and Cartilage, 19(7) (7), 903 - 910, English

  [Refereed]

  Scientific journal


• Mid-term outcomes of computer-assisted total knee arthroplasty

  Kazunari Ishida, Tomoyuki Matsumoto, Nobuhiro Tsumura, Seiji Kubo, Atsushi Kitagawa, Takaaki Chin, Tetsuhiro Iguchi, Masahiro Kurosaka, Ryosuke Kuroda

  Jul. 2011, Knee Surgery, Sports Traumatology, Arthroscopy, 19(7) (7), 1107 - 1112, English, International magazine

  [Refereed]

  Scientific journal


• Comparison of the clinical outcome of double-bundle, anteromedial single-bundle, and posterolateral single-bundle anterior cruciate ligament reconstruction using hamstring tendon graft with minimum 2-year follow-up

  Norifumi Fujita, Ryosuke Kuroda, Tomoyuki Matsumoto, Motoi Yamaguchi, Masayoshi Yagi, Akio Matsumoto, Seiji Kubo, Takehiko Matsushita, Yuichi Hoshino, Koji Nishimoto, Daisuke Araki, Masahiro Kurosaka

  Jul. 2011, Arthroscopy - Journal of Arthroscopic and Related Surgery, 27(7) (7), 906 - 913, English, International magazine

  [Refereed]

  Scientific journal


• Soft tissue balance measurement in minimal incision surgery compared to conventional total knee arthroplasty

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Seiji Kubo, Kiyonori Mizuno, Keisuke Kinoshita, Kazunari Ishida, Takehiko Matsushita, Ken Sasaki, Katsumasa Tei, Koji Takayama, Hiroshi Sasaki, Shinya Oka, Masahiro Kurosaka, Ryosuke Kuroda

  Jun. 2011, Knee Surgery, Sports Traumatology, Arthroscopy, 19(6) (6), 880 - 886, English, International magazine

  [Refereed]

  Scientific journal


• Revision ACL再建術の術後成績

  荒木 大輔, 黒田 良祐, 松下 雄彦, 久保 晴司, 松本 知之, 佐々木 宏, 岡 真也, 伊藤 あい, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36(4) (4), 137 - 137, Japanese


• 半腱用筋腱を用いたMPFL再建術の術後成績

  松下 雄彦, 黒田 良祐, 久保 晴司, 松本 知之, 荒木 大輔, 佐々木 宏, 岡 真也, 松本 彰生, 伊藤 あい, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36(4) (4), 284 - 284, Japanese


• Therapeutic strategy of third-generation autologous chondrocyte implantation for osteoarthritis

  Tomoya Kuroda, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Seiji Kubo, Takehiko Matsushita, Takayuki Asahara, Masahiro Kurosaka, Ryosuke Kuroda

  May 2011, Upsala Journal of Medical Sciences, 116(2) (2), 107 - 114, English, International magazine

  [Refereed]

  Scientific journal


• Total Knee Arthroplasty Combined With Medial Patellofemoral Ligament Reconstruction for Osteoarthritic Knee With Preoperative Valgus Deformity and Chronic Patellar Dislocation

  Takehiko Matsushita, Ryosuke Kuroda, Seiji Kubo, Kiyonori Mizuno, Tomoyuki Matsumoto, Masahiro Kurosaka

  Apr. 2011, Journal of Arthroplasty, 26(3) (3), 505.e17 - 505.e20, English, International magazine

  [Refereed]

  Scientific journal


• Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

  Norifumi Fujita, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2011, Journal of Orthopaedic Research, 29(4) (4), 511 - 515, English, International magazine

  [Refereed]

  Scientific journal


• A prospective randomised study of anatomical single-bundle versus double-bundle anterior cruciate ligament reconstruction: Quantitative evaluation using an electromagnetic measurement system

  Daisuke Araki, Ryosuke Kuroda, Seiji Kubo, Norifumi Fujita, Katsumasa Tei, Koji Nishimoto, Yuichi Hoshino, Takehiko Matsushita, Tomoyuki Matsumoto, Koki Nagamune, Masahiro Kurosaka

  Mar. 2011, International Orthopaedics, 35(3) (3), 439 - 446, English, International magazine

  [Refereed]

  Scientific journal


• 解剖学的二重束ACL再建術後におけるEndoButton経時的位置変化についての評価検討

  岡 真也, 黒田 良祐, 松下 雄彦, 長宗 高樹, 荒木 大輔, 久保 晴司, 松本 知之, 佐々木 宏, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2011, 関西関節鏡・膝研究会プログラム・演題抄録, 23回, 24 - 24, Japanese


• 前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  松下 雄彦, 黒田 良祐, 佐々木 宏, 久保 晴司, 松本 知之, 岡 真也, 荒木 大輔, 高山 孝治, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2011, 日本整形外科学会雑誌, 85(3) (3), S518 - S518, Japanese


• Thermal necrosis after simultaneous tibial osteotomy and total knee arthroplasty using press-fit extension-stem

  Kazunari Ishida, Nobuhiro Tsumura, Koji Takayama, Naomasa Fukase, Atsushi Kitagawa, Takaaki Chin, Tetsuhiro Iguchi, Tomoyuki Matsumoto, Seiji Kubo, Masahiro Kurosaka, Ryosuke Kuroda

  Jan. 2011, Knee Surgery, Sports Traumatology, Arthroscopy, 19(1) (1), 112 - 114, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of G-CSF-mobilized CD34 ⁺ cells in a patient with tibial nonunion: A case report

  Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiko Miwa, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Yohei Kawakami, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Taro Shoji, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Takayuki Ono, Yasushi Koibuchi, Shin Kawamata, Masanori Fukushima, Masahiro Kurosaka, Takayuki Asahara

  2011, Cell Transplantation, 20(9) (9), 1491 - 1496, English, International magazine

  [Refereed]

  Scientific journal


• 特発性膝関節血症の3症例

  井口 貴雄, 松本 知之, 松下 雄彦, 久保 晴司, 木嶋 雄介, 垣内 裕司, 荒木 大輔, 佐々木 宏, 岡 真也, 黒田 良祐, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Jan. 2011, 中部日本整形外科災害外科学会雑誌, 54(1) (1), 198 - 198, Japanese


• A quantitative measurement system of endpoint during Lachman test with force sensor

  Shogo Kawaguchi, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2011, IEEE International Conference on Fuzzy Systems, 1453 - 1458, English

  [Refereed]

  International conference proceedings


• A development of navigation system for mosaic plasty using electromagnetic sensor

  Takayasu Toyoshima, Kouki Nagamune, Daisuke Araki, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka

  2011, IEEE International Conference on Fuzzy Systems, 1447 - 1452, English

  [Refereed]

  International conference proceedings


• An analysis method of femur and patellar for patellar subluxation diagnosis using MDCT image

  Kouki Nagamune, Shinya Oka, Hiroshi Sasaki, Daisuke Araki, Tomoyuki Matsumoto, Takehiko Matsushita, Seiji Kubo, Ryosuke Kuroda, Masahiro Kurosaka

  2011, Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics, 764 - 768, English

  [Refereed]

  International conference proceedings


• Six Degree of Freedom Calculation Based on Principal Component Analysis for the Knee Joint in MDCT Image

  Yosuke Uozumi, Kouki Nagamune, Takehiko Matsushita, Seiji Kubo, Daisuke Araki, Tomoyuki Matsumoto

  2011, IEEE INTERNATIONAL CONFERENCE ON FUZZY SYSTEMS (FUZZ 2011), 1436 - 1441, English

  [Refereed]

  International conference proceedings


• Orthopaedic physical examination assisting system for improvement of accuracy and reproducibility of knee laxity diagnosis

  Jun Okamoto, Yu Kumasaka, Kazuya Kawamura, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Masahiro Kurosaka, Masakatsu G. Fujie

  The Japan Society of Mechanical Engineers, 2011, Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C, 77(773) (773), 138 - 148, Japanese

  [Refereed]

  Scientific journal


• Study of anatomical landmark sampling error effect on motion measurement reproducibility for Orthopaedic physical examination assisting system

  Jun Okamoto, Yu Kumasaka, Kazuya Kawamura, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Masahiro Kurosaka, Masakatsu G. Fujie

  The Japan Society of Mechanical Engineers, 2011, Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C, 77(782) (782), 3780 - 3793, Japanese

  [Refereed]

  Scientific journal


• Double ACL sign 内側半月板バケツ柄状損傷の1例

  Matsushita Takehiko, Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Jan. 2011, スポーツ傷害, 16, 13, Japanese

  Research society


• Femoral component placement changes soft tissue balance in posterior-stabilized total knee arthroplasty

  Hirotsugu Muratsu, Tomoyuki Matsumoto, Seiji Kubo, Akihiro Maruo, Hidetoshi Miya, Masahiro Kurosaka, Ryosuke Kuroda

  Nov. 2010, Clinical Biomechanics, 25(9) (9), 926 - 930, English, International magazine

  [Refereed]

  Scientific journal


• Bone regeneration properties of granulocyte colony-stimulating factor via neovascularization and osteogenesis

  Kazunari Ishida, Tomoyuki Matsumoto, Ken Sasaki, Yutaka Mifune, Katsumasa Tei, Seiji Kubo, Takehiko Matsushita, Koji Takayama, Toshihiro Akisue, Yasuhiko Tabata, Masahiro Kurosaka, Ryosuke Kuroda

  Oct. 2010, Tissue Engineering - Part A, 16(10) (10), 3271 - 3284, English, International magazine

  [Refereed]

  Scientific journal


• X線画像による膝蓋骨脱臼のスクリーニング

  伊藤 あい, 黒田 良祐, 松下 雄彦, 久保 晴司, 松本 知之, 荒木 大輔, 高山 孝治, 佐々木 宏, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2010, 日本臨床スポーツ医学会誌, 18(4) (4), S179 - S179, Japanese


• スポーツ愛好家の変形性膝関節症に対し骨軟骨柱移植術を併用した高位脛骨骨切り術を施行した2症例

  岡 真也, 黒田 良祐, 松下 雄彦, 久保 晴司, 松本 知之, 荒木 大輔, 佐々木 宏, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2010, 日本臨床スポーツ医学会誌, 18(4) (4), S186 - S186, Japanese


• Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing

  Tomoyuki Matsumoto, Masaaki Ii, Hiromi Nishimura, Taro Shoji, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Tomoaki Fukui, Yohei Kawakami, Tomoya Kuroda, Sang Mo Kwon, Hiroto Iwasaki, Miki Horii, Ayumi Yokoyama, Akira Oyamada, Sang Yang Lee, Shinya Hayashi, Masahiro Kurosaka, Satoshi Takaki, Takayuki Asahara

  Sep. 2010, Journal of Experimental Medicine, 207(10) (10), 2207 - 2223, English, International magazine

  [Refereed]

  Scientific journal


• ACL再建術の長期成績 再断裂防止に向けた展望 ACL損傷に対する治療 今後の展望

  黒田 良祐, 松下 雄彦, 山口 基, 松本 彰生, 久保 晴司, 松本 知之, 荒木 大輔, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 10 - 10, Japanese


• ACL再建術における骨孔の経時的変化

  荒木 大輔, 黒田 良祐, 長宗 高樹, 久保 晴司, 松下 雄彦, 松本 知之, 伊藤 あい, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 19 - 19, Japanese


• 当科で施行したACL augmentationの臨床成績

  佐々木 宏, 黒田 良祐, 松下 雄彦, 久保 晴司, 松本 知之, 荒木 大輔, 高山 孝治, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 188 - 188, Japanese


• 解剖学的2重束前十字靱帯再建術の術後成績

  松下 雄彦, 黒田 良祐, 松本 彰生, 久保 晴司, 松本 知之, 藤田 周史, 荒木 大輔, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2010, JOSKAS, 35(4) (4), 205 - 205, Japanese


• Navigation CR TKAでのtibia first手技を用いたDependent法による軟部組織バランス

  Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Jun. 2010, JOSKAS, 35巻, 4号, pp. 36-36, Japanese

  International conference proceedings


• Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis

  Taro Shoji, Masaaki Ii, Yutaka Mifune, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Sang Mo Kwon, Tomoya Kuroda, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  Apr. 2010, Laboratory Investigation, 90(4) (4), 637 - 649, English, International magazine

  [Refereed]

  Scientific journal


• 膝前十字靱帯損傷の徒手検査における検者間での違い アンケート調査と電磁センサーシステムを用いた計測より

  松下 雄彦, 黒田 良祐, 久保 晴司, 荒木 大輔, 長宗 高樹, 星野 祐一, 松本 知之, 佐々木 謙, 西本 浩司, 鄭 克真, 黒坂 昌弘

  (公社)日本整形外科学会, Apr. 2010, 日本整形外科学会雑誌, 84(4) (4), S263 - S263, Japanese


• 陳旧性前十字靱帯不全膝における膝最大伸展位での脛骨前方偏位の検討

  佐々木 宏, 黒田 良祐, 久保 晴司, 松下 雄彦, 松本 知之, 荒木 大輔, 高山 孝治, 松本 彰生, 黒坂 昌弘

  (公社)日本整形外科学会, Apr. 2010, 日本整形外科学会雑誌, 84(4) (4), S591 - S591, Japanese


• 前十字靱帯に関するエキスパート実技 膝前十字靱帯に関する徒手検査の標準化と今後の展望

  黒坂 昌弘, 黒田 良祐, 長宗 高樹, 久保 晴司, 山口 基, 松下 雄彦, 松本 知之, 荒木 大輔, 佐々木 謙

  (公社)日本整形外科学会, Mar. 2010, 日本整形外科学会雑誌, 84(3) (3), S184 - S184, Japanese


• 人工膝関節置換術における軟部組織バランス PS型TKAとCR型TKAでの比較

  Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro, Kuroda Ryosuke

  Mar. 2010, 日本整形外科学会雑誌 84巻, 84巻, 3号, pp. S140-S140, Japanese

  International conference proceedings


• 人工膝関節置換術における最小侵襲手技が軟部組織バランスに及ぼす影響

  Matsumoto Tomoyuki, Kubo Seiji, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 34-35, Japanese

  [Refereed]

  Scientific journal


• Revision ACL再建術を施行した症例の検討

  Kuroda Ryosuke, Kubo Seiji, Matsumoto Tomoyuki, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 88-89, Japanese

  [Refereed]

  Scientific journal


• Puddu plateを用いたopen-wedge高位脛骨骨切り術の治療成績

  Kuroda Ryosuke, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 184-185, Japanese

  [Refereed]

  Scientific journal


• 3T-MRIにおける関節軟骨変性の定性的、定量的評価 病理組織像との比較

  Kubo Seiji, Kuroda Ryosuke, Matsumoto Tomoyuki, Sugimura Kazuro, Kurosaka Masahiro

  Mar. 2010, JOSKAS, 35巻, 1号, pp. 4-5, Japanese

  [Refereed]

  Scientific journal


• Pneumocephalus associated with cerebrospinal fluid fistula as a complication of spinal surgery: A case report

  Ken Sasaki, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Toshihiro Akisue, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka, Ryosuke Kuroda

  Hindawi Limited, 2010, Case Reports in Medicine, 2010, 328103 - 328103, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 骨端線閉鎖前の反復性膝蓋骨脱臼に対するsuture anchorを用いたMPFL再建術

  佐々木 宏, 黒田 良祐, 松下 雄彦, 久保 晴司, 松本 知之, 荒木 大輔, 高山 孝治, 黒坂 昌弘

  スポーツ傷害フォーラム, Jan. 2010, スポーツ傷害, 15, 8 - 8, Japanese


• Bilateral double-layered lateral meniscus: A report of two cases

  Koji Takayama, Ryosuke Kuroda, Tomoyuki Matsumoto, Daisuke Araki, Norifumi Fujita, Katsumasa Tei, Yutaka Mifune, Keisuke Oe, Takehiko Matsushita, Seiji Kubo, Keisuke Kinoshita, Akio Matsumoto, Masahiro Kurosaka

  Oct. 2009, Knee Surgery, Sports Traumatology, Arthroscopy, 17(11) (11), 1336 - 1339, English, International magazine

  [Refereed]

  Scientific journal


• 変形性膝関節症を呈するアスリートに対し高位脛骨骨切り術を施行した2症例

  高山 孝治, 黒田 良祐, 久保 晴司, 松下 雄彦, 松本 知之, 荒木 大輔, 佐々木 宏, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2009, 日本臨床スポーツ医学会誌, 17(4) (4), S151 - S151, Japanese


• SIRT1 regulation of apoptosis of human chondrocytes

  Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kuroda

  Sep. 2009, Arthritis and Rheumatism, 60(9) (9), 2731 - 2740, English, International magazine

  [Refereed]

  Scientific journal


• SIRT1はヒト軟骨細胞のアポトーシスをミトコンドリア経路を介して制御する

  高山 孝治, 黒田 良祐, 石田 一成, 松下 雄彦, 藤田 周史, 荒木 大輔, 鄭 克真, 佐々木 謙, 松本 知之, 久保 晴司, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1183 - S1183, Japanese


• 膝前十字靱帯部分断裂症例の動作解析 三次元電磁気計測システムを用いた定量的評価

  荒木 大輔, 久保 晴司, 黒田 良祐, 西本 浩司, 星野 祐一, 松本 知之, 松下 雄彦, 山口 基, 長宗 高樹, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1222 - S1222, Japanese


• Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1

  Tomoyuki Matsumoto, Gregory M. Cooper, Burhan Gharaibeh, Laura B. Meszaros, Guangheng Li, Arvydas Usas, Freddie H. Fu, Johnny Huard

  May 2009, Arthritis and Rheumatism, 60(5) (5), 1390 - 1405, English, International magazine

  [Refereed]

  Scientific journal


• The intra-operative joint gap in cruciate-retaining compared with posterior-stabilised total knee replacement

  T. Matsumoto, R. Kuroda, S. Kubo, H. Muratsu, K. Mizuno, M. Kurosaka

  Apr. 2009, Journal of Bone and Joint Surgery - Series B, 91(4) (4), 475 - 480, English

  [Refereed]

  Scientific journal


• Soft Tissue Balance Measurement in Posterior-Stabilized Total Knee Arthroplasty With a Navigation System

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Nobuhiro Tsumura, Kiyonori Mizuno, Masahiro Kurosaka, Ryosuke Kuroda

  Apr. 2009, Journal of Arthroplasty, 24(3) (3), 358 - 364, English, International magazine

  [Refereed]

  Scientific journal


• Pivotal Role of Lnk Adaptor Protein in Endothelial Progenitor Cell Biology for Vascular Regeneration

  Sang Mo Kwon, Takahiro Suzuki, Atsuhiko Kawamoto, Masaaki Ii, Masamichi Eguchi, Hiroshi Akimaru, Mika Wada, Tomoyuki Matsumoto, Haruchika Masuda, Yoshihiro Nakagawa, Hiromi Nishimura, Kenji Kawai, Satoshi Takaki, Takayuki Asahara

  Apr. 2009, Circulation Research, 104(8) (8), 969 - 977, English, International magazine

  [Refereed]

  Scientific journal


• ACL再建術の生体力学 前十字靱帯再建前後の膝安定性評価 電磁気センサーによる三次元解析

  黒田 良祐, 星野 祐一, 西本 浩司, 荒木 大輔, 久保 晴司, 松下 雄彦, 松本 知之, 山口 基, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2009, 日本整形外科学会雑誌, 83(3) (3), S607 - S607, Japanese


• Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells

  Seiji Kubo, Gregory M. Cooper, Tomoyuki Matsumoto, Julie A. Phillippi, Karin A. Corsi, Arvydas Usas, Guangheng Li, Freddie H. Fu, Johnny Huard

  Jan. 2009, Arthritis and Rheumatism, 60(1) (1), 155 - 165, English, International magazine

  [Refereed]

  Scientific journal


• The influence of sex on the chondrogenic potential of muscle-derived stem cells implications for cartilage regeneration and repair

  Tomoyuki Matsumoto, Seiji Kubo, Laura B. Meszaros, Karin A. Corsi, Gregory M. Cooper, Guangheng Li, Arvydas Usas, Aki Osawa, Freddie H. Fu, Johnny Huard

  Dec. 2008, Arthritis and Rheumatism, 58(12) (12), 3809 - 3819, English, International magazine

  [Refereed]

  Scientific journal


• Cellular and histological differences between ACL bundles of Goat Knee

  Ho Lee, Tomoyuki Matsumoto, Masahiro Nozaki, Sheila J.M. Ingham, Freddie H. Fu

  Dec. 2008, Tissue Engineering and Regenerative Medicine, 5(4-6) (4-6), 565 - 571, English

  [Refereed]

  Scientific journal


• Circulating endothelial/skeletal progenitor cells for bone regeneration and healing

  Tomoyuki Matsumoto, Ryosuke Kuroda, Yutaka Mifune, Atsuhiko Kawamoto, Taro Shoji, Masahiko Miwa, Takayuki Asahara, Masahiro Kurosaka

  Sep. 2008, Bone, 43(3) (3), 434 - 439, English, International magazine

  [Refereed]

  Scientific journal


• Enhancement of tendon-bone osteointegration of anterior cruciate ligament graft using granulocyte colony-stimulating factor

  Ken Sasaki, Ryosuke Kuroda, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Yutaka Mifune, Keisuke Kinoshita, Katsumasa Tei, Toshihiro Akisue, Yasuhiko Tabata, Masahiro Kurosaka

  Aug. 2008, American Journal of Sports Medicine, 36(8) (8), 1519 - 1527, English, International magazine

  [Refereed]

  Scientific journal


• Local delivery of granulocyte colony stimulating factor-mobilized CD34-positive progenitor cells using bioscaffold for modality of unhealing bone fracture

  Yutaka Mifune, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Hiroto Iwasaki, Sang M.O. Kwon, Masahiko Miwa, Masahiro Kurosaka, Takayuki Asahara

  Jun. 2008, Stem Cells, 26(6) (6), 1395 - 1405, English, International magazine

  [Refereed]

  Scientific journal


• Fracture induced mobilization and incorporation of bone marrow-derived endothelial progenitor cells for bone healing

  Tomoyuki Matsumoto, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Hiroto Iwasaki, Takahiro Suzuki, Akira Oyamada, Miki Horii, Ayumi Yokoyama, Hiromi Nishimura, Yang Lee Sang, Masahiko Miwa, Minoru Doita, Masahiro Kurosaka, Takayuki Asahara

  Apr. 2008, Journal of Cellular Physiology, 215(1) (1), 234 - 242, English, International magazine

  [Refereed]

  Scientific journal


• Regenerating musculoskeletal tissues: Possibilities for rheumatoid diseases

  Tomoyuki Matsumoto, Andres J. Quintero, Freddie H. Fu, Johnny Huard

  Apr. 2008, Future Rheumatology, 3(2) (2), 183 - 197


• Administrations of peripheral blood CD34-positive cells contribute to medial collateral ligament healing via vasculogenesis

  Katsumasa Tei, Tomoyuki Matsumoto, Yutaka Mifune, Kazunari Ishida, Ken Sasaki, Taro Shoji, Seiji Kubo, Atsuhiko Kawamoto, Takayuki Asahara, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2008, Stem Cells, 26(3) (3), 819 - 830, English, International magazine

  [Refereed]

  Scientific journal


• Erratum to "Idiopathic osteonecrosis of the second metatarsal head" [Clinical Imaging 31 (2007) 431--433] (DOI:10.1016/j.clinimag.2007.03.008)

  Yutaka Mifune, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2008, Clinical Imaging, 32(2) (2), 164, English

  [Refereed]

  Scientific journal


• Isolation and characterization of connective tissue progenitor cells derived from human fracture-induced hemarthrosis in vitro

  Yang Lee Sang, Masahiko Miwa, Yoshitada Sakai, Ryosuke Kuroda, Keisuke Oe, Takahiro Niikura, Tomoyuki Matsumoto, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Feb. 2008, Journal of Orthopaedic Research, 26(2) (2), 190 - 199, English, International magazine

  [Refereed]

  Scientific journal


• Blocking VEGF as a potential approach to improve cartilage healing after osteoarthritis

  Tomoyuki Matsumoto, G. M. Cooper, B. Gharaibeh, L. B. Meszaros, G. Li, A. Usas, F. H. Fu, J. Huard

  2008, Journal of Musculoskeletal Neuronal Interactions, 8(4) (4), 316 - 317

  International conference proceedings


• Bone regeneration with local controlled application of granulocyte colony-stimulating factor (G-CSF) in a bone defect of rabbit ulna

  K. Ishida, R. Kuroda, K. Sasaki, Y. Mifune, K. Tei, M. Miwa, T. Matsumoto, Y. Tabata, M. Kurosaka

  AMER SOC BONE & MINERAL RES, Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, T161, English

  [Refereed]

  Scientific journal


• Influence of intra-operative joint gap on post-operative flexion angle in osteoarthritis patients undergoing posterior-stabilized total knee arthroplasty

  Tomoyuki Matsumoto, Kiyonori Mizuno, Hirotsugu Muratsu, Nobuhiro Tsumura, Naomasa Fukase, Seiji Kubo, Shinichi Yoshiya, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2007, Knee Surgery, Sports Traumatology, Arthroscopy, 15(8) (8), 1013 - 1018, English, International magazine

  [Refereed]

  Scientific journal


• Synchrotron radiation coronary microangiography for morphometric and physiological evaluation of myocardial neovascularization induced by endothelial progenitor cell transplantation

  Hiroto Iwasaki, Kazuhito Fukushima, Atsuhiko Kawamoto, Keiji Umetani, Akira Oyamada, Saeko Hayashi, Tomoyuki Matsumoto, Masakazu Ishikawa, Toshihiko Shibata, Hiromi Nishimura, Hidekazu Hirai, Yutaka Mifune, Miki Horii, Kazuro Sugimura, Shigefumi Suehiro, Takayuki Asahara

  Jun. 2007, Arteriosclerosis, Thrombosis, and Vascular Biology, 27(6) (6), 1326 - 1333, English, International magazine

  [Refereed]

  Scientific journal


• In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair

  Sang Yang Lee, Masahiko Miwa, Yoshitada Sakai, Ryosuke Kuroda, Tomoyuki Matsumoto, Takashi Iwakura, Hiroyuki Fujioka, Minoru Doita, Masahiro Kurosaka

  Mar. 2007, Journal of Cellular Physiology, 210(3) (3), 561 - 566, English, International magazine

  [Refereed]

  Scientific journal


• Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone-marrow stromal cells

  R. Kuroda, K. Ishida, T. Matsumoto, T. Akisue, H. Fujioka, K. Mizuno, H. Ohgushi, S. Wakitani, M. Kurosaka

  Feb. 2007, Osteoarthritis and Cartilage, 15(2) (2), 226 - 231, English

  [Refereed]

  Scientific journal


• Idiopathic osteonecrosis of the second metatarsal head

  Yutaka Mifune, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Masahiro Kurosaka, Ryosuke Kuroda

  2007, Clinical Imaging, 31(6) (6), 431 - 433, English

  [Refereed]

  Scientific journal


• Joint gap kinematics in posterior-stabilized total knee arthroplasty measured by a new tensor with the navigation system

  Tomoyuki Matsumoto, Hirotsugu Muratsu, Nobuhiro Tsumura, Kiyonori Mizuno, Ryosuke Kuroda, Shinichi Yoshiya, Masahiro Kurosaka

  Dec. 2006, Journal of Biomechanical Engineering, 128(6) (6), 867 - 871, English, International magazine

  [Refereed]

  Scientific journal


• Clinical values in computer-assisted total knee arthroplasty

  Tomoyuki Matsumoto, Nobuhiro Tsumura, Masahiro Kurosaka, Hirotsugu Muratsu, Shinichi Yoshiya, Ryosuke Kuroda

  Dec. 2006, Orthopedics, 29(12) (12), 1115 - 1120, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing

  Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Masakazu Ishikawa, Yutaka Mifune, Hiroto Iwasaki, Masahiko Miwa, Miki Horii, Saeko Hayashi, Akira Oyamada, Hiromi Nishimura, Satoshi Murasawa, Minoru Doita, Masahiro Kurosaka, Takayuki Asahara

  Oct. 2006, American Journal of Pathology, 169(4) (4), 1440 - 1457, English, International magazine

  [Refereed]

  Scientific journal


• Bilateral painful snapping elbows triggered by daily dumbbell exercises: A case report

  Koji Tateishi, Nobuhiro Tsumura, Tomoyuki Matsumoto, Hiroyuki Fujioka, Takeshi Kokubu, Ryosuke Kuroda, Ryoichi Shiba, Masahiro Kurosaka

  May 2006, Knee Surgery, Sports Traumatology, Arthroscopy, 14(5) (5), 487 - 490, English, International magazine

  [Refereed]

  Scientific journal


• Enlarging retro-odontoid pseudotumor after expanding cervical laminoplasty in the presence of kyphosis

  Tomoyuki Matsumoto, Shozo Takada, Kazuo Tsujimoto, Takuma Ozaki, Katsuhiko Ishimoto, Nobuhiro Tsumura, Ryoichi Shiba, Masahiro Kurosaka

  May 2006, Spine Journal, 6(3) (3), 228 - 232, English

  [Refereed]

  Scientific journal


• Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction

  Hiroto Iwasaki, Atsuhiko Kawamoto, Masakazu Ishikawa, Akira Oyamada, Shuko Nakamori, Hiromi Nishimura, Kazuyo Sadamoto, Miki Horii, Tomoyuki Matsumoto, Satoshi Murasawa, Toshihiko Shibata, Shigefumi Suehiro, Takayuki Asahara

  Mar. 2006, Circulation, 113(10) (10), 1311 - 1325, English, International magazine

  [Refereed]

  Scientific journal


• Synchrotron radiation coronary microangiography for morphometric and physiological evaluation of myocardial neovascularization induced by cell-based transplantation

  Iwasaki H, Kawamoto A, Fukushima K, Umetani K, Oyamada A, Hayashi S, Gokurakuji K, Matsumoto T, Shibata T, Suehiro S, Asahara T

  Feb. 2006, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 47(4) (4), 292A - 292A, English

  [Refereed]

  Scientific journal


• Donor leukocytes combined with delayed immunosupressive drug therapy prolong limb allograft survival

  T Matsumoto, T Kanatani, M Lanzetta, H Fujioka, M Kurosaka, GW McCaughan, GA Bishop

  Dec. 2005, TRANSPLANTATION PROCEEDINGS, 37(10) (10), 4630 - 4633, English

  [Refereed]

  Scientific journal


• Influence of hip position on knee flexion angle in patients undergoing total knee arthroplasty

  Tomoyuki Matsumoto, Nobuhiro Tsumura, Seiji Kubo, Ryoichi Shiba, Masahiro Kurosaka, Shinichi Yoshiya

  Aug. 2005, Journal of Arthroplasty, 20(5) (5), 669 - 673, English, International magazine

  [Refereed]

  Scientific journal


• Donor leukocytes combine with immunosuppressive drug therapy to prolong limb allograft survival

  T Kanatani, M Lanzetta, E Owen, T Matsumoto, H Fujioka, M Kurosaka, GW McCaughan, GA Bishop

  Jun. 2005, TRANSPLANTATION PROCEEDINGS, 37(5) (5), 2382 - 2384, English

  [Refereed]

  Scientific journal


• Traumatic dislocation of the hamate and pisiform: A case report and review of the literature

  Tomoyuki Matsumoto, Masaya Tsunoda, Shinji Yamaguchi, Kiyoyasu Koso, Shinji Matsushita, Masahiro Kurosaka, Shinichi Yoshiya

  Apr. 2005, Journal of Orthopaedic Trauma, 19(4) (4), 282 - 285, English, International magazine

  [Refereed]

  Scientific journal


• Prosthetic alignment and sizing in computer-assisted total knee arthroplasty

  Tomoyuki Matsumoto, Nobuhiro Tsumura, Masahiro Kurosaka, Hirotsugu Muratsu, Ryosuke Kuroda, Katsuhiko Ishimoto, Kazuo Tsujimoto, Ryoichi Shiba, Shinichi Yoshiya

  Oct. 2004, International Orthopaedics, 28(5) (5), 282 - 285, English, International magazine

  [Refereed]

  Scientific journal


• 小児に発生した舟状骨・有頭骨同時骨折の1例

  福井 友章, 藤岡 宏幸, 国分 毅, 中路 教義, 松本 知之, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, May 2004, 中部日本整形外科災害外科学会雑誌, 47(3) (3), 597 - 597, Japanese


• Massive nonspecific olecranon bursitis with multiple rice bodies

  Tomoyuki Matsumoto, Kenji Fujita, Hiroyuki Fujioka, Shinji Matsushima, Kiyoyasu Kouso, Shinji Yamaguchi, Masahiro Kurosaka, Shinichi Yoshiya

  2004, Journal of Shoulder and Elbow Surgery, 13(6) (6), 680 - 683, English

  [Refereed]

  Scientific journal


• Donor leukocytes administration combined with immunosupressive therapy in limb transplantation: Early report

  T Kanatani, M Lanzetta, E Owen, T Matsumoto, H Fujioka, M Kurosaka, GW McCaughan, AG Bishop

  2004, PROCEEDINGS OF THE 9TH CONGRESS OF THE INTERNATIONAL FEDERATION OF SOCIETIES FOR SURGERY OF THE HAND, 119 - 122, English

  [Refereed]

  International conference proceedings


• Stress fracture of the first rib in a soccer player: A rare etiology of shoulder pain

  Tomoyuki Matsumoto, Kenji Fujita, Hiroyuki Fujioka, Masaya Tsunoda, Shinichi Yoshiya, Masahiro Kurosaka, Kosaku Mizuno

  Mar. 2003, Journal of Shoulder and Elbow Surgery, 12(2) (2), 197 - 199, English

  [Refereed]

  Scientific journal


• Solitary intraarticular lipoma causing sudden locking of the knee: A case report and review of the literature

  Shinji Yamaguchi, Tetsuji Yamamoto, Shinji Matsushima, Shinichi Yoshiya, Nobuaki Matsubara, Tomoyuki Matsumoto

  2003, American Journal of Sports Medicine, 31(2) (2), 297 - 299, English

  [Refereed]

  Scientific journal

• Orthopaedic specialist training program in Kobe University

  松本 知之, 美舩 泰, 黒田 良祐

  日本整形外科学会, Sep. 2021, 日本整形外科学会雑誌 = The Journal of the Japanese Orthopaedic Association, 95(9) (9), 613 - 616, Japanese


• Pelvic morphology medial to the femoral head center predicts anterior coverage and range of motion after curved periacetabular osteotomy

  Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Koji Fukuda, Koji Takayama, Masanori Tsubosaka, Yoshinori Takashima, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto

  01 Sep. 2020, Journal of Orthopaedic Research, 38(9) (9), 2031 - 2039, English, International magazine


• Intraoperative Soft Tissue Balance/Kinematics and Clinical Evaluation of Modified Kinematically versus Mechanically Aligned Total Knee Arthroplasty

  Tomoyuki Matsumoto, Koji Takayama, Kazunari Ishida, Yuichi Kuroda, Masanori Tsubosaka, Hirotsugu Muratsu, Shinya Hayashi, Shingo Hashimoto, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda

  01 Aug. 2020, Journal of Knee Surgery, 33(8) (8), 777 - 784, English, International magazine

  [Refereed]


• Intraoperative pelvic movement is associated with the body mass index in patients undergoing total hip arthroplasty in the supine position

  Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Koji Takayama, Takaaki Fujishiro, Takafumi Hiranaka, Ryosuke Kuroda, Tomoyuki Matsumoto

  May 2020, Journal of Orthopaedic Science, 25(3) (3), 446 - 451, English, Domestic magazine

  [Refereed]


• Cell therapy for patients with femoral and tibial Nonunion

  黒田良祐, 新倉隆宏, 福井友章, 大江啓介, 松本知之

  2020, 骨折(Web), 42(Supplement) (Supplement)


• 脂肪由来幹細胞の難治性骨折に対する治癒促進効果

  亀長 智幸, 松本 知之, 高山 孝治, 林 申也, 橋本 慎吾, 福田 康治, 黒田 雄一, 壺坂 正徳, 高島 良典, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1753 - S1753, Japanese


• 変形性膝関節症に対する多血小板血漿関節腔内注射の治療効果の検討

  山下 貴大, 傍島 聰, 松本 知之, 松下 雄彦, 岩畔 英樹, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1947 - S1947, Japanese


• エイコサペンタエン酸含有ゼラチンハイドロゲルは変形性関節症進行を抑制する

  壺坂 正徳, 林 申也, 木原 伸介, 永田 純平, 高島 良典, 亀長 智幸, 高山 孝治, 橋本 慎吾, 松本 知之, 田畑 泰彦, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1954 - S1954, Japanese


• Current concepts and future perspectives in computer-assisted navigated total knee replacement

  Tomoyuki Matsumoto, Naoki Nakano, John E. Lawrence, Vikas Khanduja

  Springer Verlag, 03 Jun. 2019, International Orthopaedics, 43(6) (6), 1337 - 1343, English, International magazine

  [Refereed]

  Book review


• Topical cutaneous application of CO2 accelerates bone healing in a rat femoral defect model

  Yu Kuroiwa, Tomoaki Fukui, Shunsuke Takahara, Sang Yang Lee, Keisuke Oe, Michio Arakura, Yohei Kumabe, Takahiro Oda, Tomoyuki Matsumoto, Takehiko Matsushita, Toshihiro Akisue, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  22 May 2019, BMC Musculoskeletal Disorders, 20(1) (1), 237 - 237, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects

  Yu Kuroiwa, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda

  02 May 2019, International Orthopaedics, 43(5) (5), 1247 - 1253, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Effect of intraoperative soft tissue balance on postoperative recovery of ambulatory and balancing function in posterior-stabilized total knee arthroplasty

  Masanori Tsubosaka, Hirotsugu Muratsu, Koji Takayama, Akihiro Maruo, Hidetoshi Miya, Ryosuke Kuroda, Tomoyuki Matsumoto

  May 2019, Journal of Orthopaedic Science, 24(3) (3), 507 - 513, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Accuracy of cup orientation and learning curve of the accelerometer-based portable navigation system for total hip arthroplasty in the supine position

  Tomoyuki Kamenaga, Shinya Hayashi, Shingo Hashimoto, Tomoyuki Matsumoto, Koji Takayama, Takaaki Fujishiro, Takafumi Hiranaka, Takahiro Niikura, Ryosuke Kuroda

  01 May 2019, Journal of Orthopaedic Surgery, 27(2) (2), 2309499019848871

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• ACL遺残組織温存の賛否 前十字靱帯再建術における遺残組織に含まれる血管由来細胞の治癒能

  松本 知之, 松下 雄彦, 星野 祐一, 荒木 大輔, 美舩 泰, 高山 孝治, 橋本 真吾, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2019, JOSKAS, 44(4) (4), 564 - 564, Japanese


• Deterioration of patellofemoral cartilage status after medial open-wedge high tibial osteotomy

  Toshikazu Tanaka, Takehiko Matsushita, Nobuaki Miyaji, Kazuyuki Ibaraki, Kyohei Nishida, Shinya Oka, Daisuke Araki, Noriyuki Kanzaki, Yuichi Hoshino, Tomoyuki Matsumoto, Ryosuke Kuroda

  Apr. 2019, Knee Surgery, Sports Traumatology, Arthroscopy, 27(4) (4), 1347 - 1354, English, International magazine

  [Refereed]


• Changes in knee extensor strengths before and after medial patellofemoral ligament reconstruction

  Takehiko Matsushita, Daisuke Araki, Tomoyuki Matsumoto, Takahiro Niikura, Ryosuke Kuroda

  Apr. 2019, Physician and Sportsmedicine, 47(2) (2), 220 - 226, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 【人工膝関節置換術をめぐる議論】Kinematic alignmentの臨床成績 靱帯バランスの影響

  松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 161 - 166, Japanese


• 【人工膝関節置換術をめぐる議論】後十字靱帯温存型人工膝関節全置換術(CR-TKA)における外側laxityは術後の屈曲可動域に影響を及ぼす因子である

  中野 直樹, 松本 知之, 高山 孝治, 黒田 良祐

  (株)アークメディア, Apr. 2019, Bone Joint Nerve, 9(2) (2), 191 - 195, Japanese


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 【人工膝関節置換術のインプラントと術式の選択】人工膝関節全置換術の術式選択 人工膝関節全置換術におけるナビゲーション使用の意義と課題

  松本 知之, 高山 孝治, 佐々木 宏, 石田 一成, 黒田 良祐

  (株)メジカルビュー社, Mar. 2019, 関節外科, 38(3) (3), 291 - 295, Japanese


• 軟骨損傷を伴った習慣性膝蓋骨脱臼に対して脛骨粗面前内方近位移行および内側膝蓋大腿靱帯再建術にて良好な成績を得た1例

  渡邉 秀, 荒木 大輔, 松下 雄彦, 神崎 至幸, 松本 知之, 高山 孝治, 黒田 良祐

  (株)メジカルビュー社, Mar. 2019, 関節外科, 38(3) (3), 330 - 335, Japanese


• PS型人工膝関節全置換術における術後1年の患者満足度に及ぼす術後早期膝安定性の影響

  澤内 健一, 村津 裕嗣, 尾ノ井 勇磨, 渡邊 秀, 神村 真人, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Mar. 2019, JOSKAS, 44(1) (1), 186 - 187, Japanese


• 内反型変形性膝関節症に対するPS-TKAにおける脛骨コンポーネント後傾角が術後1年の臨床成績に及ぼす影響

  神村 真人, 村津 裕嗣, 尾ノ井 勇磨, 渡邉 秀, 澤内 健一, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2018, 日本人工関節学会誌, 48, 55 - 56, Japanese


• CR型人工膝関節全置換術における術後1年の患者満足度に及ぼす術後膝安定性の影響

  澤内 健一, 村津 裕嗣, 尾ノ井 勇磨, 渡邉 秀, 神村 真人, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2018, 日本人工関節学会誌, 48, 429 - 430, Japanese


• PS型人工膝関節全置換術、術後1年の移動歩行能力の予測

  澤内 健一, 村津 裕嗣, 尾ノ井 勇磨, 渡邉 秀, 神村 真人, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2018, 日本人工関節学会誌, 48, 219 - 220, Japanese


• 難治性骨折、関節軟骨損傷に対する再生医療

  黒田良祐, 新倉隆宏, Matsushita Takehiko, 松本知之

  Aug. 2018, 日本整形外科学会雑誌, 92(8号) (8号), S1634, Japanese

  [Invited]

  Introduction scientific journal


• PS型人工膝関節全置換術における手術術式が術後膝安定性に及ぼす影響

  神田 裕太郎, 村津 裕嗣, 八尋 俊輔, 亀長 智幸, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2018, JOSKAS, 43(2) (2), 388 - 389, Japanese


• PS-TKAにおける術後屈曲位膝関節安定性が術後1年の移動歩行能力回復に及ぼす影響

  亀長 智幸, 村津 裕嗣, 八尋 俊輔, 神田 裕太郎, 大島 隆司, 松本 知之, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2018, JOSKAS, 43(2) (2), 316 - 317, Japanese


• 【ACL損傷-予防、治療・手術から競技復帰まで-】 ACL再建術の現状と将来 ACL再建術における再生医療の応用

  Matsumoto Tomoyuki, 美舩泰, 松下雄彦, Kuroda Ryosuke

  (株)文光堂, Apr. 2018, 臨床スポーツ医学, 35(4号) (4号), 384 - 389, Japanese

  Introduction scientific journal


• 難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法―医師主導治験の経験から―

  黒田良祐, 大江啓介, 福井友章, 新倉隆宏, 松本知之

  2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.SY‐35‐5 (WEB ONLY), Japanese


• Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討

  竹内 一裕, 橋本 慎吾, 松本 知之, 林 申也, 高山 孝治, 木原 伸介, 井口 高雄, 桐月 伸輔, 羽田 勝彦, 黒田 雄一, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2017, 日本人工関節学会誌, 47, 643 - 644, Japanese


• PS型人工膝関節全置換術におけるmedial preserving gap techniqueとmeasured resection techniqueの術後膝安定性の比較

  神田 裕太郎, 村津 裕嗣, 片岡 君成, 八尋 俊輔, 亀長 智幸, 大島 隆司, 古賀 敬章, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐

  (一社)日本人工関節学会, Dec. 2017, 日本人工関節学会誌, 47, 573 - 574, Japanese


• 人工膝関節全置換術と人工股関節全置換術の術後患者満足度の比較

  山裏 耕平, 村津 裕嗣, 工藤 健史, 大島 隆司, 松本 知之, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2017, JOSKAS, 42(2) (2), 216 - 217, Japanese


• 人工膝関節全置換術における術後膝関節安定性が患者満足度に及ぼす影響

  山裏 耕平, 村津 裕嗣, 工藤 健史, 大島 隆司, 松本 知之, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2017, JOSKAS, 42(2) (2), 218 - 219, Japanese


• PS型人工膝関節全置換術におけるmedial gap法とmeasured resection法の術中軟部組織バランスの比較検討

  工藤 健史, 村津 裕嗣, 山裏 耕平, 大島 隆司, 松本 知之, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2017, JOSKAS, 42(2) (2), 274 - 275, Japanese


• 【膝靱帯損傷-up to date-】 将来の治療 膝靱帯損傷における再生医療の応用

  Matsumoto Tomoyuki, Mifune Yutaka, 松下雄彦, Kuroda Ryosuke

  (株)メジカルビュー社, Mar. 2017, 関節外科, 36(3号) (3号), 290 - 295, Japanese

  [Refereed]

  Introduction scientific journal


• PS-TKAにおける大腿骨後顆骨切り量が術後1年の膝自動可動域に及ぼす影響

  工藤 健史, 村津 裕嗣, 古川 隆浩, 山裏 耕平, 南埜 正五郎, 大島 隆司, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2016, 日本人工関節学会誌, 46, 261 - 262, Japanese


• 人工膝関節全置換術における下肢機能の経時的変化

  山裏 耕平, 村津 裕嗣, 古川 隆浩, 工藤 健史, 南埜 正五郎, 大島 隆司, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2016, 日本人工関節学会誌, 46, 15 - 16, Japanese


• 人工膝関節全置換術の術後移動歩行能力改善に及ぼす膝安定性の影響

  山裏 耕平, 村津 裕嗣, 古川 隆浩, 工藤 健史, 南埜 正五郎, 大島 隆司, 松本 知之, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2016, 日本人工関節学会誌, 46, 21 - 22, Japanese


• 恒久性膝蓋骨脱臼を伴った変形性膝関節症に対して人工膝関節置換術を施行した1例

  鎌田 紘平, 松本 知之, 高山 孝治, 荒木 大輔, 松下 雄彦, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2016, 中部日本整形外科災害外科学会雑誌, 59(6) (6), 1165 - 1166, Japanese


• 軟骨損傷を伴った習慣性膝蓋骨脱臼に対して脛骨粗面前内方近位移行および内側膝蓋大腿靱帯再建術にて良好な成績を得た1例

  渡邉 秀, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 鎌田 紘平, 神崎 至幸, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2016, 中部日本整形外科災害外科学会雑誌, 59(5) (5), 1085 - 1086, Japanese


• 【人工膝関節全置換術の機種選択と手術支援機器の活用】 ナビゲーション機種間による相違

  Matsumoto Tomoyuki, 高山孝治, 佐々木宏, 石田一成, Kuroda Ryosuke

  Sep. 2016, 関節外科, 35(9号) (9号), 936 - 941, Japanese

  [Refereed][Invited]

  Introduction scientific journal


• マウス変形性関節症モデルに対するシンバスタチン含有ゼラチンハイドロゲル関節内投与による関節症進行抑制効果

  田中 聡一, 松下 雄彦, 高山 孝治, 長井 寛斗, 西田 京平, 井口 貴雄, 張 樹蓉, 荒木 大輔, 松本 知之, 田畑 泰彦, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1468 - S1468, Japanese


• 前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響

  桐月 伸輔, 松本 知之, 井口 貴雄, 田中 聡一, 西田 京平, 中野 直樹, 長井 寛斗, 荒木 大輔, 高山 孝治, 松下 雄彦, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2016, 日本整形外科学会雑誌, 90(8) (8), S1786 - S1786, Japanese


• Multilayer scaffolds in orthopaedic tissue engineering

  Kivanc Atesok, M. Nedim Doral, Jon Karlsson, Kenneth A. Egol, Laith M. Jazrawi, Paulo G. Coelho, Amaury Martinez, Tomoyuki Matsumoto, Brett D. Owens, Mitsuo Ochi, Shepard R. Hurwitz, Anthony Atala, Freddie H. Fu, Helen H. Lu, Scott A. Rodeo

  Springer Verlag, 01 Jul. 2016, Knee Surgery, Sports Traumatology, Arthroscopy, 24(7) (7), 2365 - 2373, English, International magazine

  [Refereed]

  Book review


• 【骨癒合促進の最前線】 自家末梢血CD34陽性細胞による難治性骨折の治療

  Matsumoto Tomoyuki, Niikura Takahiro, Mifune Yutaka, 福井友章, 川上洋平, Kuroda Ryosuke

  金原出版(株), May 2016, 整形・災害外科, 59(5号) (5号), 557 - 565, Japanese

  [Refereed][Invited]

  Introduction scientific journal


• INTRAPERITONEAL INJECTION OF THE SIRT1 ACTIVATOR SRT1720 ATTENUATES THE PROGRESSION OF EXPERIMENTAL OSTEOARTHRITIS IN MICE

  K. Nishida, T. Matsushita, K. Takayama, K. Nagai, T. Tanaka, T. Inokuchi, S. Kirizuki, D. Araki, T. Matsumoto, M. Kurosaka, R. Kuroda

  Apr. 2016, OSTEOARTHRITIS AND CARTILAGE, 24, S359 - S360, English

  Summary international conference


• F-1-2 Development of the Surgical Navigation System as Modularized Software

  OKAMOTO Jun, SUZUKI Shigeyuki, MATSUMOTO Tomoyuki, MURATSU Yuji, MURAGAKI Yoshihiro, MASAMUNE Ken

  By integrating the image and position information from intraoperative modality, surgical navigation system and positioning robot, it is possible to realize new precision-guided surgery that does not depend on each manufacturer or specific model. In the study, we have developed a modular navigation system as the software for the "Tensor robot" that measures the knee soft tissue balance during performing Total knee arthroplasty (TKA). In this paper, we report on the Cadaver experiments by using these integrated equipments.

  The Japan Society of Mechanical Engineers, 14 Mar. 2016, Conference on Information, Intelligence and Precision Equipment : IIP, 2016, "F - 1-2-1"-"F-1-2-2", Japanese


• 複合靱帯損傷に対する治療 陳旧性複合靱帯損傷に対する治療

  松下 雄彦, 黒田 良祐, 井口 貴雄, 荒木 大輔, 松本 知之, 高山 孝治, 長井 寛斗, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S316 - S316, Japanese


• ACL不全膝・再建膝の評価 膝前十字靱帯不全膝・再建膝の評価 三次元電磁気センサーを用いた評価

  黒田 良祐, 松下 雄彦, 星野 祐一, 長宗 高樹, 荒木 大輔, 長井 寛斗, 西田 京平, 井口 貴雄, 高山 孝治, 松本 知之, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S480 - S480, Japanese


• 膝前十靱帯前内側束・後外側束が膝関節安定性へ及ぼす役割 三次元電磁気センサーを用いた定量的評価

  荒木 大輔, 黒田 良祐, 松下 雄彦, 西田 京平, 井口 貴雄, 中野 直樹, 長井 寛斗, 高山 孝治, 松本 知之, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(3) (3), S580 - S580, Japanese


• MISの功罪 人工膝関節置換術におけるMISの功罪

  松本知之, 高山孝治, Kuroda Ryosuke, Kurosaka Masahiro

  医学書院, Feb. 2016, 臨床整形外科, 51(2号) (2号), 117 - 122, Japanese

  [Invited]

  Introduction commerce magazine


• 骨膜パッチを用いない自家培養軟骨細胞移植―医師主導治験

  黒田良祐, 松下雄彦, 松本知之, 高山孝治, 長井寛斗, 西田京平, 井口貴雄, 荒木大輔, 新倉隆宏, 中野直樹, 岡真也, 黒坂昌弘

  Feb. 2016, 日本軟骨代謝学会プログラム・抄録集, 29th, 68, Japanese


• マウス変形性関節症モデルに対するSRT1720腹腔内投与による関節症進行抑制効果

  西田京平, 松下雄彦, 高山孝治, 長井寛斗, 井口貴雄, ZHANG Shurong, 荒木大輔, 松本知之, 黒田良祐, 黒坂昌弘

  Feb. 2016, 日本軟骨代謝学会プログラム・抄録集, 29th, 101, Japanese


• BMP2導入前十字靭帯(ACL)由来幹細胞移植はラットACL再建術における移植腱の治癒を促進する

  川上洋平, 小林真, 小林真, 高山孝治, 高山孝治, 松本知之, 黒田良祐, 黒坂昌弘, FU Freddie, HUARD Johnny

  01 Feb. 2016, 再生医療, 15, 274, Japanese


• 内反型変形性膝関節症に対する人工膝関節全置換術術後下肢アライメントと臨床成績の関係

  西田京平, 松本知之, 高山孝治, 中野直樹, 長井寛斗, 井口貴雄, 桐月伸輔, 田中聡一, 荒木大輔, 松下雄彦, 黒田良祐, 黒坂昌弘

  2016, 日本人工関節学会プログラム・抄録集, 46th, 357, Japanese


• CR型人工膝関節全置換術における術中外側laxityは術後膝屈曲角度に影響を及ぼす因子である

  中野直樹, 松本知之, 村津裕嗣, 石田一成, 高山孝治, 松下雄彦, 荒木大輔, 長井寛斗, 西田京平, 井口貴雄, 黒田良祐, 黒坂昌弘

  2016, 日本人工関節学会プログラム・抄録集, 46th, 397, Japanese


• PS型TKAにおける術中軟部組織バランスが術後膝安定性・可動域に及ほす影響

  井口貴雄, 松本知之, 村津裕嗣, 石田一成, 高山孝治, 松下雄彦, 荒木大輔, 長井寛斗, 中野直樹, 黒田良祐, 黒坂昌弘

  2016, 日本人工関節学会プログラム・抄録集, 46th, 505, Japanese


• PS型人工膝関節全置換術の術後膝安定性の検討 modified gap法とmeasured resection法の比較

  竹森 俊幸, 村津 裕嗣, 松本 知之, 長井 寛斗, 鈴木 孝洋, 壺坂 正徳, 大島 隆司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2015, 日本人工関節学会誌, 45, 353 - 354, Japanese


• 変形性膝関節症治療のガイドラインと新戦略 変形性関節症におけるエピジェネティクスとエピジェネティクス関連因子

  松下 雄彦, 松崎 時夫, 長井 寛斗, 高山 孝治, 西田 京平, 松本 知之, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節病学会, Oct. 2015, 日本関節病学会誌, 34(3) (3), 313 - 313, Japanese


• 【骨・軟骨の再生】 末梢血由来細胞移植による骨再生医療

  Kuroda Ryosuke, Niikura Takahiro, Matsumoto Tomoyuki, Lee Sangyang, Kurosaka Masahiro

  Oct. 2015, 腎と骨代謝, 28(4号) (4号), 301 - 307, Japanese

  [Invited]

  Introduction scientific journal


• 外傷後の広範囲大腿骨内顆骨壊死に対して骨移植と骨軟骨柱移植術を併用して高位脛骨骨切り術を行った一例

  渡邉 秀, 松下 雄彦, 黒田 良祐, 松本 知之, 長井 寛斗, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 167 - 167, Japanese


• 単純X線膝側面像を用いた膝蓋骨不安定症のスクリーニング法の開発

  長井 寛斗, 黒田 良祐, 松下 雄彦, 松本 知之, 荒木 大輔, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2015, 中部日本整形外科災害外科学会雑誌, 58(秋季学会) (秋季学会), 170 - 170, Japanese


• 膝前十字靱帯損傷膝の遺残組織の治癒能 受傷時期が及ぼす影響

  井口 貴雄, 松本 知之, 高山 孝治, 松下 雄彦, 荒木 大輔, 上藤 敦郎, 長井 寛斗, 中野 直樹, 西田 京平, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Sep. 2015, 日本整形外科学会雑誌, 89(8) (8), S1435 - S1435, Japanese


• Corrigendum to "A radiographic analysis of alignment of the lower extremities - initiation and progression of varus-type knee osteoarthritis" [Osteoarthr Cartil 23, (2015), 217-223] DOI: 10.1016/j.joca.2014.11.015

  T. Matsumoto, M. Hashimura, K. Takayama, K. Ishida, Y. Kawakami, T. Matsuzaki, N. Nakano, T. Matsushita, R. Kuroda, M. Kurosaka

  01 Aug. 2015, Osteoarthritis and Cartilage, 23(8) (8), 1432 - 1433, English


• 膝蓋骨不安定症の病態と治療 高度脱臼素因例への対応

  松下 雄彦, 黒田 良祐, 岡 真也, 荒木 大輔, 星野 祐一, 松本 知之, 長井 寛斗, 高山 孝治, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 129 - 129, Japanese


• 単純X線膝側面像による膝蓋骨不安定症のスクリーニング CT画像との比較

  長井 寛斗, 黒田 良祐, 松下 雄彦, 荒木 大輔, 松本 知之, 高山 孝治, 中野 直樹, 張 樹蓉, 井口 貴雄, 西田 京平, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 157 - 157, Japanese


• 膝前十字靱帯損傷への取り組み 膝前十字靱帯(ACL)再建膝評価 スポーツ復帰に向けた取り組み

  黒田 良祐, 松下 雄彦, 星野 祐一, 荒木 大輔, 西田 京平, 井口 貴雄, 長井 寛斗, 高山 孝治, 中野 直樹, 松本 知之, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 323 - 323, Japanese


• 膝前十靱帯前内側束・後外側束が膝関節安定性へ及ぼす役割 三次元電磁気センサーを用いた定量的評価

  荒木 大輔, 黒田 良祐, 松下 雄彦, 西田 京平, 井口 貴雄, 長井 寛斗, 中野 直樹, 高山 孝治, 松本 知之, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 353 - 353, Japanese


• 前十字靱帯再建術における前方制動性と関節内靱帯張力を適正する為の初期固定張力の検討

  星野 祐一, 黒田 良祐, 西澤 勇一郎, 長井 寛斗, 荒木 大輔, 中野 直樹, 松下 雄彦, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 354 - 354, Japanese


• 単顆型人工膝関節置換術における脛骨後方傾斜の変化が及ぼす影響

  高山 孝治, 松本 知之, 村津 裕嗣, 西田 京平, 井口 貴雄, 中野 直樹, 長井 寛斗, 荒木 大輔, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2015, JOSKAS, 40(4) (4), 580 - 580, Japanese


• 【整形外科領域における再生医療の最前線】 自家末梢血CD34陽性細胞移植による難治性骨折の治療

  Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki, Kurosaka Masahiro

  May 2015, 関節外科, 34(5号) (5号), 466 - 472, Japanese

  [Invited]

  Introduction commerce magazine


• 人工膝関節全置換術における術中軟部組織バランスが膝蓋大腿関節接触圧に及ぼす影響

  松本知之, 高山孝治, 川上洋平, 佐々木宏, 柴沼均, 石田一成, 村津裕嗣, 松下雄彦, 黒田良祐, 黒坂昌弘

  12 Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S714, Japanese


• 内側膝蓋大腿靱帯再建術においてX線透視下に決定した大腿骨骨孔位置で再建靱帯は適切な長さ変化を示すか

  松下 雄彦, 黒田 良祐, 星野 祐一, 佐々木 謙, 荒木 大輔, 岡 真也, 松本 知之, 西澤 勇一朗, 長井 寛斗, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S745 - S745, Japanese


• Modified gap法に準じた新たな手術手技(medial gap technique)を用いた人工膝関節全置換術での術中軟部組織バランス評価 CRとPS TKAの比較

  竹森 俊幸, 村津 裕嗣, 松本 知之, 長井 寛斗, 高島 良典, 壺坂 正徳, 大島 隆司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2015, 日本整形外科学会雑誌, 89(3) (3), S903 - S903, Japanese


• シンバスタチンは半月板修復を促進する

  ZHANG Shurong, 松下雄彦, 黒田良祐, 松崎時夫, 岡真也, 長井寛斗, 高山孝治, 松本知之, 上藤淳郎, 中野直樹, 田畑泰彦, 黒坂昌弘

  Feb. 2015, 日本軟骨代謝学会プログラム・抄録集, 28th, 114, Japanese


• シンバスタチンの半月板損傷に対する有効性の検討

  張樹蓉, 松下雄彦, 黒田良祐, 松崎時夫, 岡真也, 長井寛斗, 高岡孝治, 松本知之, 上藤淳郎, 中野直樹, 黒坂昌弘, 田畑泰彦

  01 Feb. 2015, 再生医療, 14, 223, Japanese


• Soft tissue balance in total knee arthroplasty (Intra-operative measurement and its application)

  村津 裕嗣, 松本 知之, 宮 秀俊

  アークメディア, Jan. 2015, Bone joint nerve : BJN, 5(1) (1), 93 - 101, Japanese


• 内反型変形性膝関節症に対するにCR型人工膝関節全置換術術後下肢アライメントと臨床成績の関係

  西田京平, 松本知之, 高山孝治, 石田一成, 川上洋平, 中野直樹, 井口貴雄, 荒木大輔, 松下雄彦, 黒田良祐, 黒坂昌弘

  2015, 日本人工関節学会プログラム・抄録集, 45th, 406, Japanese


• 軟部バランス:CR TKAにおける手技

  松本知之, 高山孝治, 村津裕嗣, 石田一成, 川上洋平, 松崎時夫, 中野直樹, 松下雄彦, 黒田良祐, 黒坂昌弘

  2015, 日本人工関節学会プログラム・抄録集, 45th, 281, Japanese


• 人工膝関節全置換術術後の脛骨回旋移動評価―3次元術前評価ソフトAthenaとNavigationでの比較―

  井口貴雄, 松本知之, 高山孝治, 上藤淳郎, 川上洋平, 中野直樹, 西田京平, 石田一成, 松下雄彦, 黒田良祐, 黒坂昌弘

  2015, 日本人工関節学会プログラム・抄録集, 45th, 409, Japanese


• Autologous transplantation of G-CSF-mobilized CD34-positive cells for patients with femoral and tibial nonunion : Phase 1/2 Clinical Trial

  松本 知之, 新倉 隆宏, 川上 洋平

  日本整形外科学会, Jan. 2015, 日本整形外科学会雑誌, 89(1) (1), 26 - 32, Japanese


• 最新基礎科学 知っておきたい 自家末梢血CD34陽性細胞による偽関節治療

  Matsumoto Tomoyuki, Niikura Takahiro, Kurosaka Masahiro, Kuroda Ryosuke

  Jan. 2015, 臨床整形外科, 50(1号) (1号), 32 - 35, Japanese

  Introduction scientific journal


• 前十字靱帯再建術時に施行した半月板縫合術の術後再鏡視評価と治療成績に及ぼす因子の検討

  松下 雄彦, 黒田 良祐, 長井 寛斗, 松本 知之, 星野 祐一, 荒木 大輔, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2014, 日本臨床スポーツ医学会誌, 22(4) (4), S213 - S213, Japanese


• 膝前十字靱帯再建術後の治癒能力の年齢による差異に関する検討

  中野 直樹, 松本 知之, 高山 孝治, 松下 雄彦, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1429 - S1429, Japanese


• バイオメカニクスと手術・リハビリテーションへの応用 前十字靱帯損傷膝の定量評価

  黒田 良祐, 長井 寛斗, 中野 直樹, 荒木 大輔, 松下 雄彦, 星野 祐一, 長宗 高樹, 松本 知之, 高山 孝治, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1607 - S1607, Japanese


• 膝前十字靱帯再建術における移植腱初期固定張力の関節内への伝達率の検討

  長井 寛斗, 黒田 良祐, 星野 祐一, 西澤 勇一郎, 荒木 大輔, 中野 直樹, 松下 雄彦, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1611 - S1611, Japanese


• シンバスタチンのヒト半月板に対する有効性の検討

  張 樹蓉, 松下 雄彦, 松本 知之, 高山 孝治, 松崎 時夫, 岡 真也, 長井 寛斗, 上藤 淳郎, 中野 直樹, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2014, 日本整形外科学会雑誌, 88(8) (8), S1658 - S1658, Japanese


• CR-TKAにおける内側解離と脛骨内旋運動量の関係

  松本 知之, 高山 孝司, 石田 一成, 松崎 時夫, 中野 直樹, 上藤 淳郎, 長井 寛斗, 村津 裕嗣, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 131 - 131, Japanese


• Tibial tuberosity-trochlear groove distance高値患者における内側膝蓋大腿靱帯再建術術後成績

  松下 雄彦, 黒田 良祐, 岡 真也, 松本 知之, 星野 祐一, 長井 寛斗, 西澤 勇一朗, 中野 直樹, 松崎 時夫, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 137 - 137, Japanese


• 単顆型人工膝関節置換術における術中gap計測はインサートサイズ選択の指標となる

  高山 孝治, 松本 知之, 村津 裕嗣, 中野 直樹, 上藤 淳郎, 長井 寛斗, 石田 一成, 柴沼 均, 松下 雄彦, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 157 - 157, Japanese


• シンバスタチンのヒト半月板に対する有効性の検討

  張 樹蓉, 松下 雄彦, 松本 知之, 高山 孝治, 松崎 時夫, 岡 真也, 長井 寛斗, 上藤 淳郎, 中野 直樹, 黒坂 昌弘, 黒田 良祐

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 353 - 353, Japanese


• 解剖学的前十字靱帯再建術の大腿骨骨孔周辺にかかる圧分布の評価

  星野 祐一, 黒田 良祐, 西澤 勇一郎, 長井 寛斗, 荒木 大輔, 中野 直樹, 松下 雄彦, 松本 知之, 高山 孝司, 長宗 高樹, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 369 - 369, Japanese


• 膝前十字靱帯再建術における初期固定張力の関節内への伝達率の検討

  長井 寛斗, 黒田 良祐, 星野 祐一, 西澤 勇一郎, 荒木 大輔, 中野 直樹, 松下 雄彦, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 371 - 371, Japanese


• 外反型変形性膝関節症に対するLPS-Flexを用いた人工膝関節全置換術の術後短期臨床成績

  中野 直樹, 松本 知之, 村津 裕嗣, 松下 雄彦, 高山 孝治, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jul. 2014, JOSKAS, 39(4) (4), 398 - 398, Japanese


• 関節外変形を伴う変形性膝関節症に対する人工膝関節全置換術の術後短期臨床成績―ナビゲーション使用群と従来群での比較―

  谷和泉, 松本知之, 高山孝治, 川上洋平, 黒田雄一, 松下雄彦, 黒田良祐, 黒坂昌弘

  01 Jul. 2014, JOSKAS, 39(4) (4), 441, Japanese


• Clinical impact of circulating CD34-positive cells on bone regeneration and healing

  Ryosuke Kuroda, Tomoyuki Matsumoto, Yohei Kawakami, Tomoaki Fukui, Yutaka Mifune, Masahiro Kurosaka

  01 Jun. 2014, Tissue Engineering - Part B: Reviews, 20(3) (3), 190 - 199, English, International magazine

  [Refereed]


• 【骨折の診断と治療 最新update】 新しい骨折治療法 末梢血CD34陽性細胞移植による骨・血管再生

  Lee Sangyang, Kuroda Ryosuke, Niikura Takahiro, Matsumoto Tomoyuki, Kurosaka Masahiro

  May 2014, 整形・災害外科, 57(6号) (6号), 647 - 652, Japanese

  Introduction scientific journal


• POSITIVE EFFECTS OF SIMVASTATIN ON HUMAN MENISCAL CELLS AND MENISCAL HEALING

  S. Zhang, T. Matsushita, T. Matsumoto, K. Takayama, T. Matsuzaki, S. Oka, K. Nagai, A. Uefuji, N. Nakano, M. Kurosaka, R. Kuroda

  Apr. 2014, OSTEOARTHRITIS AND CARTILAGE, 22, S314 - S314, English

  Summary international conference


• REMOTE ASSESSMENTS AND INSTRUCTIONS FOR HOME-REHABILITATION VIA CUSTOM-MADE WEBSITE IN PATIENTS WITH HIP AND KNEE OSTEOARTHRITIS, A PRELIMINARY REPORT

  Y. Uesugi, C. Nishii, C. Yamada, S. Hayashi, R. Kuroda, S. Hashimoto, T. Matsumoto, T. Matsushita, T. Nishii, T. Fujishiro

  Apr. 2014, OSTEOARTHRITIS AND CARTILAGE, 22, S432 - S433, English

  Summary international conference


• アスリートにおける二次性変形性膝関節症の治療

  上藤 淳郎, 黒田 良祐, 松下 雄彦, 松本 知之, 岡 真也, 西澤 勇一郎, 松崎 時夫, 長井 寛斗, 中野 直樹, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2014, JOSKAS, 39(2) (2), 416 - 417, Japanese


• 靱帯バランス:rectangular equal balanceを目指すべきか―定量的評価よりの提言―

  松本知之, 村津裕嗣, 高山孝治, 川上洋平, 松崎時夫, 中野直樹, 長井寛斗, 上藤淳朗, 松下雄彦, 黒田良祐, 黒坂昌弘

  12 Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S505, Japanese


• 徐放化抗癌剤抱合血管内皮前駆細胞を用いた新しい骨肉腫治療法の開発

  川上洋平, 伊井正明, 松本知之, 秋末敏宏, 浅原孝之, 田畑泰彦, 朝日通雄, 黒田良祐, 黒坂昌弘

  12 Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S645, Japanese


• 人工膝関節全置換術におけるナビゲーションシステムを用いた脛骨骨棘切除前後のアライメント定量的評価

  鄭克真, 川上洋平, 松本知之, 庄司太郎, 加東武, 清水富男, 柴沼均, 黒坂昌弘, 黒田良祐

  05 Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S285, Japanese


• 血管内皮前駆細胞におけるSDF‐1/CXCR4シグナルは骨折治癒において血管・骨新生を制御する

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 美舩泰, 黒田知也, 庄司太郎, 朝日通雄, 浅原孝之, 黒田良祐, 黒坂昌弘

  05 Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S458, Japanese


• 膝蓋骨不安定症の病態と治療 内側膝蓋大腿靱帯再建術術後成績評価と成績に及ぼす因子の検討

  松下 雄彦, 黒田 良祐, 岡 真也, 松本 知之, 西澤 勇一郎, 星野 祐一, 長井 寛斗, 松崎 時夫, 上藤 淳夫, 中野 直樹, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(2) (2), S343 - S343, Japanese


• 三次元電磁気センサーを用いた前十字靱帯損傷膝における遺残組織の関節制動性評価

  長井 寛斗, 黒田 良祐, 荒木 大輔, 西澤 勇一郎, 松下 雄彦, 星野 祐一, 松本 知之, 高山 孝治, 長宗 高樹, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2014, 日本整形外科学会雑誌, 88(3) (3), S1006 - S1006, Japanese


• SDF-1/CXCR4 Axis in Endothelial Progenitor Cells Regulates Both Vasculogenesis and Osteogenesis for Bone Fracture Healing

  Yohei Kawakami, Msaaki Ii, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Yutaka Mifune, Ryosuke Kuroda, Takayuki Asahara, Masahiro Kurosaka

  Feb. 2014, JOURNAL OF BONE AND MINERAL RESEARCH, 29, S386 - S387, English

  Summary international conference


• 患者まで届いている再生医療 軟骨の再生

  Kuroda Ryosuke, 松下 雄彦, Matsumoto Tomoyuki, Kurosaka Masahiro

  Feb. 2014, 再生医療, 13(1) (1), 52 - 57, Japanese

  [Refereed]

  Introduction scientific journal


• 偽関節患者を対象とした,自家末梢血CD34陽性細胞を用いた骨・血管再生療法

  松本知之, 新倉隆宏, 川上洋平, 福井友章, 美舩泰, 李相亮, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  27 Jan. 2014, 再生医療, 13, 139, Japanese


• 人工膝関節全置換術における2011Knee Society Scoreを用いた患者立脚型評価

  上藤淳郎, 松本知之, 高山孝治, 松下雄彦, 岡真也, 松崎時夫, 長井寛斗, 中野直樹, 黒田良祐, 黒坂昌弘

  2014, 日本人工関節学会プログラム・抄録集, 44th, 399, Japanese


• 第2世代拘束型人工関節を用いた人工膝関節再置換術の術後成績

  中野直樹, 松本知之, 村津裕嗣, 柴沼均, 松下雄彦, 石田一成, 高山孝治, 上藤淳郎, 長井寛斗, 黒田良祐, 黒坂昌弘

  2014, 日本人工関節学会プログラム・抄録集, 44th, 529, Japanese


• ヒト軟骨細胞においてSIRT6抑制は細胞老化,DNA損傷,テロメア機能不全をきたす

  長井寛斗, 松下雄彦, 松崎時夫, 高山孝治, 上藤淳郎, ZHANG Shurong, 中野直樹, 西澤勇一郎, 松本知之, 黒田良祐, 黒坂昌弘

  2014, 日本軟骨代謝学会プログラム・抄録集, 27th, 136, Japanese


• CR‐TKAにおける術中軟部組織バランスが術後1年以上経過の術後成績に及ぼす影響―術後膝屈曲角度を中心に―

  松崎時夫, 松本知之, 村津裕嗣, 松下雄彦, 高山孝治, 長井寛斗, 上藤淳郎, 中野直樹, 黒田良祐, 黒坂昌弘

  2014, 日本人工関節学会プログラム・抄録集, 44th, 568, Japanese


• 人工膝関節全置換術における膝蓋大腿関節接触圧の検討―Fixed型とMobile型インサートの比較―

  高山孝治, 松本知之, 柴沼均, 村津裕嗣, 松崎時夫, 長井寛斗, 上藤淳郎, 中野直樹, 松下雄彦, 黒田良祐, 黒坂昌弘

  2014, 日本人工関節学会プログラム・抄録集, 44th, 466, Japanese


• 術中軟部組織バランス評価―臨床的意義―屈曲バランスは平行が至適か?

  松本知之, 村津裕嗣, 高山孝治, 川上洋平, 松崎時夫, 中野直樹, 上藤淳郎, 松下雄彦, 黒田良祐, 黒坂昌弘

  2014, 日本人工関節学会プログラム・抄録集, 44th, 284, Japanese


• 人工膝関節全置換術におけるナビゲーションシステムを用いた脛骨骨棘切除前後のアライメント定量的評価

  鄭克真, 川上洋平, 松本知之, 庄司太郎, 清水富男, 加東武, 柴沼均, 黒坂昌弘, 黒田良祐

  2014, 日本人工関節学会プログラム・抄録集, 44th, 458, Japanese


• 競技レベルの高いスポーツ選手の膝半月板単独損傷に対する半月板縫合術の治療成績

  長井 寛斗, 黒田 良祐, 松下 雄彦, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4) (4), S242 - S242, Japanese


• 内側膝蓋大腿靱帯再建術後の膝伸展筋力の回復経過

  松下 雄彦, 黒田 良祐, 柴田 洋平, 滝口 耕平, 松本 知之, 西澤 勇一郎, 長井 寛斗, 高山 孝治, 岡 真也, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2013, 日本臨床スポーツ医学会誌, 21(4) (4), S244 - S244, Japanese


• Matching of articular surface shape of selected donor and recipient sites for cylindrical osteochondral grafts of the femur -quantitative evaluation using a three dimensional laser scanner

  Yuichiro Nishizawa, Tomoyuki Matsumoto, Takehiko Matsushita, Koki Nagamune, Yuichi Hoshino, Daisuke Araki, Shinya Oka, Tokio Matsuzaki, Masahiro Kurosaka, Ryosuke Kuroda

  SAGE Publications Ltd, Sep. 2013, Orthopaedic Journal of Sports Medicine, 1(4) (4), English

  Report scientific journal


• 膝前十字靱帯由来細胞の細胞特性における年齢による差異の検討

  上藤淳郎, 松本知之, 松下雄彦, 川上洋平, 岡真也, 西澤勇一郎, 松崎時夫, 長井寛斗, 黒田良祐, 黒坂昌弘

  30 Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1508, Japanese


• 偽関節患者を対象とした,自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本知之, 新倉隆宏, 川上洋平, 福井友章, 美舩泰, 李相亮, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  30 Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1545, Japanese


• ヒト軟骨細胞における長寿遺伝子SIRT6による役割の検討

  長井 寛斗, 松下 雄彦, 松崎 時夫, 松本 知之, 張 樹蓉, 高山 孝治, 岡 真也, 西澤 勇一郎, 上藤 淳郎, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1359 - S1359, Japanese


• 軟骨変性の病態 長寿因子SIRT1による軟骨変性と変形性関節症における役割

  松下 雄彦, 黒田 良祐, 松崎 時夫, 高山 孝治, 石田 一成, 佐々木 宏, 松本 知之, 藤田 周史, 長井 寛斗, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1520 - S1520, Japanese


• マウス変形性関節症モデルにおける徐放化rapamycin投与の関節症進行抑制効果

  松崎 時夫, 松下 雄彦, 高山 孝治, 松本 知之, 岡 真也, 長井 寛斗, 上藤 淳郎, 齊藤 高志, 田畑 泰彦, 黒田 良祐, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1605 - S1605, Japanese


• 【人工膝関節置換術update】 靱帯バランス 臨床的意義

  Matsumoto Tomoyuki, 村津 裕嗣, 松下 雄彦, Kuroda Ryosuke, Kurosaka Masahiro

  金原出版, Aug. 2013, 整形・災害外科, 56(9号) (9号), 1075 - 1082, Japanese

  Introduction scientific journal


• 半月板損傷に対する治療法の現状と展望 半月板縫合術の治療成績

  黒田 良祐, 松下 雄彦, 長井 寛斗, 松本 知之, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 117 - 117, Japanese


• 当科における前十字靱帯再建術時に半月板縫合術を行った症例の治療成績

  松下 雄彦, 黒田 良祐, 長井 寛斗, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 249 - 249, Japanese


• 当科での膝半月板単独損傷に対する半月板縫合術の治療成績

  長井 寛斗, 黒田 良祐, 松下 雄彦, 松本 知之, 星野 祐一, 岡 真也, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 251 - 251, Japanese


• 人工膝単顆置換術の術中tensor計測において各関節引き離し力が術後屈曲角度に及ぼす影響

  松崎 時夫, 松本 知之, 村津 裕嗣, 鄭 克真, 松下 雄彦, 柴沼 均, 岡 真也, 長井 寛斗, 上藤 敦郎, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 298 - 298, Japanese


• 反復性膝蓋骨脱臼患者に対するMPFL再建術時の大腿骨再建位置シミュレーション

  岡 真也, 黒田 良祐, 松下 雄彦, 多治見 寛之, 松本 知之, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2013, JOSKAS, 38(4) (4), 551 - 551, Japanese


• Coxitis Kneeに対するTKAの経験

  黒田雄一, 松本知之, 向原伸太郎, 川上洋平, 松下雄彦, 黒田良祐, 黒坂昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, 01 Jun. 2013, JOSKAS, 38(4) (4), 571 - 571, Japanese


• 前十字靭帯再建術後における膝最大伸展位での脛骨前方偏位の検討

  西澤勇一郎, 黒田良祐, 松下雄彦, 松本知之, 川上洋平, 岡真也, 松崎時夫, 上藤淳郎, 長井寛斗, 長宗高樹, 黒坂昌弘

  01 Jun. 2013, JOSKAS, 38(4) (4), 175, Japanese


• アスリートにおける二次性変形性膝関節症の治療

  上藤淳郎, 黒田良祐, 松下雄彦, 松本知之, 川上洋平, 岡真也, 西澤勇一郎, 松崎時夫, 長井寛斗, 黒坂昌弘

  01 Jun. 2013, JOSKAS, 38(4) (4), 348, Japanese


• 人工膝関節全置換術における術中軟部組織バランスと膝蓋大腿関節接触圧の関係

  松本知之, 柴沼均, 川上洋平, 村津裕嗣, 岡真也, 松崎時夫, 松下雄彦, 黒田良祐, 黒坂昌弘

  01 Jun. 2013, JOSKAS, 38(4) (4), 536, Japanese


• 大腿骨・脛骨の関節外変形および対側THA後の高度外反膝に対してTKAを施行した1例

  向原伸太郎, 松本知之, 久保晴司, 松下雄彦, 川上洋平, 谷和泉, 黒田雄一, 黒田良祐, 黒坂昌弘

  01 Jun. 2013, JOSKAS, 38(4) (4), 574, Japanese


• The influence of intra-operative soft tissue balance on post-operative knee extension in PS-TKA

  TAKAHARA Shunsuke

  25 Apr. 2013, JOSKAS, 38(2) (2), 252 - 253, Japanese


• INTRA-ARTICULAR ADMINISTRATION OF GELATIN HYDROGELS INCORPORATING RAPAMYCIN-MICELLE REDUCES DEVELOPMENT OF EXPERIMENTAL OSTEOARTHRITIS IN A MURINE MODEL

  T. Matsuzaki, T. Matsushita, Y. Tabata, T. Saito, T. Matsumoto, K. Nagai, M. Kurosaka, R. Kuroda

  Apr. 2013, OSTEOARTHRITIS AND CARTILAGE, 21, S111 - S111, English

  Summary international conference


• 【整形外科領域と再生医療】 骨・軟骨再生 末梢血CD34陽性細胞移植による難治性骨折治療

  Matsumoto Tomoyuki, Niikura Takahiro, Kuroda Ryosuke

  Apr. 2013, Pharma Medica, 31(4号) (4号), 9 - 13, Japanese

  Introduction scientific journal


• 【再生医療の現況と最前線】 再生医療の現状と展望 細胞を用いた再生医療 自家末梢血幹細胞(CD34陽性細胞)による難治性骨折(偽関節)への応用

  Kuroda Ryosuke, Niikura Takahiro, Matsumoto Tomoyuki, Lee Sangyang, Kurosaka Masahiro

  Apr. 2013, 整形・災害外科, 56(5号) (5号), 553 - 557, Japanese

  Introduction scientific journal


• CR型およびPS型人工膝関節全置換術における軟部組織バランス―Measured resection techniqueとgap techniqueの比較―

  松本知之, 村津裕嗣, 久保晴司, 松下雄彦, 川上洋平, 岡真也, 松崎時夫, 長井寛斗, 黒田良祐, 黒坂昌弘

  05 Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S488, Japanese


• 血管内皮細胞におけるSDF‐1/CXCR4シグナルは骨折治癒過程で血管・骨新生を制御する

  川上洋平, 黒田知也, 松本知之, 伊井正明, 川本篤彦, 美舩泰, 庄司太郎, 福井友章, 黒田良祐, 浅原孝之, 黒坂昌弘

  05 Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S288, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 庄司太郎, 美舩泰, 福井友章, 黒田良祐, 浅原孝之, 黒坂昌弘

  05 Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S289, Japanese


• 細胞内アダプター蛋白Lnkの局所制御による早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 美舩泰, 庄司太郎, 福井友章, 秋丸裕司, 黒田良祐, 浅原孝之, 黒坂昌弘

  05 Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S239, Japanese


• 前十字靱帯再建術前後における膝最大伸展位での脛骨前方偏位の検討

  西澤 勇一郎, 黒田 良祐, 松下 雄彦, 松本 知之, 川上 洋平, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2013, 関西関節鏡・膝研究会プログラム・演題抄録, 25回, 26 - 26, Japanese


• 正常ACL機能再現に向けての我々の再建術式 当科における解剖学的二重束ACL再建術及びACL補強術

  松下 雄彦, 黒田 良祐, 西澤 勇一郎, 長井 寛斗, 松本 知之, 松崎 時夫, 上藤 淳郎, 星野 祐一, 荒木 大輔, 黒坂 昌弘

  関西関節鏡・膝研究会, Mar. 2013, 関西関節鏡・膝研究会プログラム・演題抄録, 25回, 40 - 40, Japanese


• 前十字靱帯部分損傷に対する後外側線維束補強術の術後臨床成績

  松下 雄彦, 黒田 良祐, 西澤 勇一郎, 松本 知之, 星野 祐一, 久保 晴司, 松崎 時夫, 長井 寛斗, 上藤 淳郎, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S467 - S467, Japanese


• 未来への扉 膝 前十字靱帯部分損傷に対する術前、術後評価、補強術

  松下 雄彦, 黒田 良祐, 西澤 勇一郎, 荒木 大輔, 松本 知之, 星野 祐一, 長井 寛斗, 松崎 時夫, 上藤 敦朗, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S531 - S531, Japanese


• Tibial tuberosity-trochlear groove distanceのMPFL再建術術後成績へ及ぼす影響

  松下 雄彦, 黒田 良祐, 岡 真也, 松本 知之, 久保 晴司, 西澤 勇一郎, 松崎 時夫, 上藤 淳郎, 長井 寛斗, 黒坂 昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S885 - S885, Japanese


• 前十字靱帯損傷による膝の不安定性と再建術後の不安定性の残存に関与する潜在的不安定性の定量的評価

  星野 祐一, 西澤 勇一郎, 長井 寛斗, 松本 知之, 松下 雄彦, 長宗 高樹, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(3) (3), S956 - S956, Japanese


• CT‐free navigation systemを使用したTKAの中期臨床成績

  黒田雄一, 松本知之, 川上洋平, 松下雄彦, 黒田良祐, 黒坂昌弘

  (一社)中部日本整形外科災害外科学会, 01 Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56(春季学会) (春季学会), 214 - 214, Japanese


• Offset‐type tensorによる人工膝関節全置換術における軟部組織バランス

  松本知之, 村津裕嗣, 松下雄彦, 川上洋平, 黒田良祐, 黒坂昌弘

  01 Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56, 212, Japanese


• 関節外変形を伴う膝OAに対しナビゲーションを併用してTKAを施行した7症例

  谷和泉, 松本知之, 川上洋平, 松下雄彦, 黒田良祐, 黒坂昌弘

  01 Mar. 2013, 中部日本整形外科災害外科学会雑誌, 56, 214, Japanese


• 外反型変形性膝関節症における術中軟部組織バランスの評価

  岡真也, 松本知之, 村津弘嗣, 松下雄彦, 川上洋平, 西澤勇一郎, 松崎時夫, 上藤淳郎, 長井寛斗, 黒田良祐, 黒坂昌弘

  2013, 日本人工関節学会プログラム・抄録集, 43rd, 273, Japanese


• CR型およびPS型人工膝関節全置換術における手技による軟部組織バランスの相違

  松本知之, 村津裕嗣, 久保晴司, 松下雄彦, 川上洋平, 岡真也, 松崎時夫, 西澤勇一郎, 長井寛斗, 上藤淳郎, 黒田良祐, 黒坂昌弘

  2013, 日本人工関節学会プログラム・抄録集, 43rd, 306, Japanese


• 人工膝単顆置換術における術中軟部組織バランスが術後アウトカムに及ぼす影響

  松崎時夫, 松本知之, 村津裕嗣, 鄭克真, 松下雄彦, 川上洋平, 柴沼均, 岡真也, 西澤勇一郎, 長井寛斗, 黒田良祐, 黒坂昌弘

  2013, 日本人工関節学会プログラム・抄録集, 43rd, 464, Japanese


• 自家末梢血CD34陽性細胞による難治性骨折の治療

  黒田良祐, 新倉隆宏, 松本知之, 李相亮, 美舩泰, 吉賀敬章, 川上洋平, 堂垣佳宏, 奥町悦子, 黒坂昌弘

  10 Dec. 2012, 移植, 47(6) (6), 497 - 498, Japanese


• TKA用ロボットテンサーの力制御性能について

  岡本 淳, 松本 知之, 久保 晴司, 村津 裕嗣, 黒坂 昌弘, 村垣 善浩, 伊関 洋

  (一社)日本コンピュータ外科学会, Oct. 2012, 日本コンピュータ外科学会誌, 14(3) (3), 366 - 367, Japanese


• 前十字靱帯部分損傷に対する後外側線維束補強術の術後臨床成績

  松下 雄彦, 黒田 良祐, 西澤 勇一郎, 久保 晴司, 松本 知之, 長井 寛斗, 星野 祐一, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2012, 日本臨床スポーツ医学会誌, 20(4) (4), S209 - S209, Japanese


• 三次元電磁気センサーを用いた膝前十字靱帯再建術による機能改善の定量的評価

  長井 寛斗, 黒田 良祐, 西澤 勇一郎, 星野 祐一, 松下 雄彦, 久保 晴司, 松本 知之, 長宗 高樹, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2012, 日本臨床スポーツ医学会誌, 20(4) (4), S211 - S211, Japanese


• 前十字靱帯損傷膝における三次元電磁気センサーを用いたPivot shift testの定量的評価

  西澤 勇一郎, 黒田 良祐, 星野 祐一, 松下 雄彦, 久保 晴司, 松本 知之, 長井 寛斗, 長宗 高樹, 黒坂 昌弘

  (一社)日本臨床スポーツ医学会, Oct. 2012, 日本臨床スポーツ医学会誌, 20(4) (4), S211 - S211, Japanese


• 軟骨エイジング そのメカニズムと評価 長寿因子SIRT1の軟骨細胞における役割

  松下 雄彦, 黒田 良祐, 松崎 時夫, 高山 孝司, 石田 一成, 佐々木 宏, 松本 知之, 藤田 周史, 長井 寛斗, 黒坂 昌弘

  (一社)日本関節病学会, Oct. 2012, 日本関節病学会誌, 31(3) (3), 349 - 349, Japanese


• PS型TKAにおけるtibial slopeおよびposterior condylar offsetが術中軟部組織バランスに及ぼす影響

  岡 真也, 松本 知之, 村津 裕嗣, 長井 寛斗, 黒田 良祐, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Sep. 2012, 中部日本整形外科災害外科学会雑誌, 55(秋季学会) (秋季学会), 74 - 74, Japanese


• 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  Matsumoto Tomoyuki, Kuroda Ryosuke

  Sep. 2012, 整形外科, 63(10号) (10号), 1060, Japanese

  [Refereed]

  Introduction scientific journal


• アテロコラーゲンを用いた細胞内アダプター蛋白Lnkの局所制御による血管・骨新生促進を介した骨折治療法

  川上洋平, 松本知之, 伊井正明, 川本篤彦, 黒田良祐, 庄司太郎, 美舩泰, 福井友章, 浅原孝之, 黒坂昌弘

  25 Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1058, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞の局所投与は骨折治癒を促進する

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 黒田良祐, 庄司太郎, 美舩泰, 福井友章, 浅原孝之, 黒坂昌弘

  25 Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1059, Japanese


• 骨折治癒過程におけるSDF‐1/CXCR4シグナルを介した血管内皮前駆細胞による血管・骨新生の制御

  川上洋平, 黒田知也, 松本知之, 美舩泰, 庄司太郎, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  25 Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1059, Japanese


• 分子レベルからみた整形外科疾患(シリーズIX) 骨折治癒遅延モデルに対する胎生期分化誘導シグナル(Sonic hedgehog)再構築の治療効果

  Matsumoto Tomoyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Aug. 2012, 整形・災害外科, 55(9号) (9号), 1056 - 1057, Japanese

  [Refereed]

  Introduction scientific journal


• 私が薦めるACL損傷からの競技復帰プラン サッカー選手のACL損傷に対する治療 損傷からの競技復帰プラン

  Kuroda Ryosuke, Kubo Seiji, Matsushita Takehiko, Matsumoto Tomoyuki, Kurosaka Masahiro

  日本臨床スポーツ医学会, Aug. 2012, 日本臨床スポーツ医学会誌, 20(3号) (3号), 394 - 396, Japanese

  [Refereed]

  Introduction scientific journal


• Emerging role of circulating calcifying cells in the bone-vascular axis

  Gian Paolo Fadini, Marcello Rattazzi, Tomoyuki Matsumoto, Takayuki Asahara, Sundeep Khosla

  05 Jun. 2012, Circulation, 125(22) (22), 2772 - 2781, English, International magazine

  [Refereed]


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法~臨床試験の報告~

  新倉隆宏, 黒田良祐, 松本知之, 李相亮, 美船泰, 古賀敬章, 川上洋平, 堂垣佳宏, 奥町悦子, 黒坂昌弘

  (一社)日本骨折治療学会, Jun. 2012, 骨折, 34(Suppl.) (Suppl.), S21 - S21, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療法

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 庄司太郎, 福井友章, 美舩泰, 秋丸裕司, 黒田良祐, 黒坂昌弘, 浅原孝之

  16 May 2012, 再生医療, 11, 239, Japanese


• Lnkの局所制御による血管・骨新生促進を通じた骨折治癒促進効果

  川上洋平, 松本知之, 伊井正明, 川本篤彦, 美舩泰, 福井友章, 庄司太郎, 秋丸裕司, 黒田良祐, 黒坂昌弘, 浅原孝之

  16 May 2012, 再生医療, 11, 265, Japanese


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法(第一報)

  Niikura Takahiro, Kuroda Ryosuke, Matsumoto Tomoyuki, Lee Sangyang, Kurosaka Masahiro

  (一社)日本骨折治療学会, May 2012, 骨折, 34(2号) (2号), 413 - 416, Japanese

  [Refereed]

  Introduction scientific journal


• 難治性骨折に対する治療 IV.骨癒合促進のチャレンジ 難治性骨折(偽関節)患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法

  黒田良祐, 新倉隆宏, 松本知之, LEE S.Y, 川上洋平, 黒坂昌弘

  (株)南江堂, 15 Apr. 2012, 別冊整形外科, (61) (61), 224 - 228, Japanese


• DISRUPTION OF SIRT1 IN CHONDROCYTES CAUSES ACCELERATED DEVELOPMENT OF OSTEOARTHRITIS INDUCED BY JOINT INSTABILITY IN THE MOUSE

  T. Matsuzaki, T. Matsushita, S. Kubo, T. Matsumoto, H. Sasaki, K. Takayama, M. Kurosaka, R. Kuroda

  Apr. 2012, OSTEOARTHRITIS AND CARTILAGE, 20, S25 - S25, English

  Summary international conference


• In Reply

  Tomoyuki Matsumoto, Hirotsugu Muratsu

  Apr. 2012, Journal of Arthroplasty, 27(4) (4), 655 - 656, English

  Report scientific journal


• PS-TKAにおける術中軟部組織バランスが術後早期の膝自動屈曲角度に及ぼす影響

  長井 寛斗, 村津 裕嗣, 松本 知之, 久保 晴司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Apr. 2012, JOSKAS, 37(2) (2), 202 - 203, Japanese


• 621 A simulation of the MPFL insertion in the living body knee using a biplanar X-ray image matching technique

  NORO Masahiro, MATSUDA Mitsumasa, KURODA Ryosuke, KUBO Seiji, MATSUSHITA Takehiko, OKA Shinya, MATSUMOTO Tomoyuki, NISHIZAWA Yuichiro, SASAKI Hiroshi, MATSUZAKI Tokio, KUROSAKA Masahiro

  The Japan Society of Mechanical Engineers, 16 Mar. 2012, 関西支部講演会講演論文集, 2012(87) (87), "6 - 18", Japanese


• 【膝蓋骨脱臼の評価と治療】 反復性膝蓋骨脱臼に対するMPFL再建術

  Kuroda Ryosuke, Matsushita Takehiko, Matsumoto Tomoyuki, Kubo Seiji, Kurosaka Masahiro

  Mar. 2012, 関節外科, 31(3号) (3号), 304 - 308, Japanese

  [Refereed]

  Introduction scientific journal


• SCF-cKitシグナル伝達系を介したLnk欠損マウスにおける早期骨折治癒

  Matsumoto Tomoyuki, Mifune Yutaka, Kuroda Ryosuke, Kurosaka Masahiro

  Mar. 2012, 日本整形外科学会雑誌, 86(3号) (3号), S655, Japanese

  Meeting report


• ゼラチンハイドロゲルを用いた運動器再生の基礎研究

  黒田良祐, 松本知之, 岡真也, 松崎時夫, 松下雄彦, 黒坂昌弘, 田畑泰彦

  2012, 第118 回中部日本整形外科災害外科学会・学術集会（2012.4.6－7．大阪）, Japanese

  [Refereed]


• マウス変形性関節症モデルに対する徐放化rapamycin 投与による関節症進行抑制効果

  松﨑時夫, 松下雄彦, 松本知之, 岡真也, 西澤勇一郎, 長井寛斗, 上藤淳郎, 斉藤高志, 田畑泰彦, 黒坂昌弘, 黒田良祐

  2012, 第2 回 DDS 徐放化再生医療研究会（2012.12.22．京都）, Japanese

  [Refereed]


• simvastatin 局所徐放による前十字靭帯再建術後の移植腱－骨孔間の成熟促進効果に ついて

  岡真也, 松本知之, 久保晴司, 松下雄彦, 佐々木宏, 西澤勇一郎, 松崎時夫, 斉藤高志, 西田康太郎, 田畑泰彦, 黒坂昌弘, 黒田良祐

  2012, 第27 回日本整形外科学会基礎学術集会（2012.10.26－27．名古屋）, Japanese

  [Refereed]


• 整形外科領域における蛍光イメージング 筋肉 筋肉における蛍光イメージング

  Matsumoto Tomoyuki, Kubo Seiji, Kuroda Ryosuke

  Jan. 2012, 臨床整形外科, 47巻, 1号, pp. 39-42, Japanese

  [Refereed]

  Introduction scientific journal


• TKA gap 関節引き離し力がPS-TKAの術中軟部組織バランス評価に及ぼす影響

  長井 寛斗, 村津 裕嗣, 松本 知之, 篠原 奈都代, 藏川 拓外, 久保 晴司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2011, 日本人工関節学会誌, 41, 242 - 243, Japanese


• TKA gap PS-TKAにおける術中軟部組織バランスが術後膝屈曲位での安定性に及ぼす影響

  長井 寛斗, 村津 裕嗣, 松本 知之, 篠原 奈都代, 藏川 拓外, 久保 晴司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本人工関節学会, Dec. 2011, 日本人工関節学会誌, 41, 252 - 253, Japanese


• 【正常像とくらべてナットク!整形外科疾患別画像の見かた読みかた】 (第2部)正常像とくらべてナットク!疾患別 画像の見かた (3章)下肢 膝関節の靱帯損傷

  Kuroda Ryosuke, Matsumoto Tomoyuki

  Nov. 2011, 整形外科看護, 巻, 2011秋季増刊, pp. 210-221, Japanese

  [Refereed]

  Introduction scientific journal


• 【人工膝関節のデザインとバイオメカニクス】 人工膝関節デザイン・材質・手技の最適化 軟部組織バランスの解析

  Matsumoto Tomoyuki

  Oct. 2011, 関節外科, 30巻, 10月増刊, pp. 39-48, Japanese

  [Refereed]

  Introduction scientific journal


• ANALYSIS OF AUTOPHAGIC ACTIVITY IN HUMAN CARTILAGE AND CHONDROCYTES

  H. Sasaki, T. Matsushita, K. Takayama, S. Kubo, T. Matsumoto, K. Ishida, S. Oka, M. Kurosaka, R. Kuroda

  Sep. 2011, OSTEOARTHRITIS AND CARTILAGE, 19, S123 - S123, English

  Summary international conference


• 細胞内アダプター蛋白質Lnkの局所制御による,早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 松本知之, 川本篤彦, 伊井正明, 美舩泰, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  25 Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1214, Japanese


• 体外増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法

  川上洋平, 松本知之, 川本篤彦, 伊井正明, 美舩泰, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  25 Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1202, Japanese


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による血管新生・骨新生を介した骨折治療

  福井友章, 伊井正明, 庄司太郎, 松本知之, 美舩泰, 川上洋平, 黒田知也, 川本篤彦, 斎藤高志, 城潤一郎, 田畑泰彦, 黒坂昌弘, 黒田良祐, 浅原孝之

  25 Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1215, Japanese


• 膝前十字靱帯再建術における損傷部靱帯組織併用療法の可能性

  松本知之, 久保晴司, 佐々木謙, 川上洋平, 佐々木宏, 高山孝治, 岡真也, 鄭克真, 美舩泰, 松下雄彦, 黒坂昌弘, 黒田良祐

  25 Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1248, Japanese


• 運動器の再生 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  松本 知之, 新倉 隆宏, 福井 友章, 美舩 泰, 川上 洋平, 三輪 雅彦, 李 相亮, 大江 啓介, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1182 - S1182, Japanese


• 偽関節患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法~第一報~

  新倉隆宏, 黒田良祐, 松本知之, 李相亮, 美舩泰, 康暁博, 古賀敬章, 堂垣佳宏, 川上洋平, 黒坂昌弘

  (一社)日本骨折治療学会, Jul. 2011, 骨折, 33(Suppl.) (Suppl.), S310 - S310, Japanese


• PS-TKAにおける術中軟部組織バランスが術後早期の膝自動屈曲角度に及ぼす影響

  長井 寛斗, 村津 裕嗣, 松本 知之, 篠原 奈都代, 藏川 拓外, 久保 晴司, 圓尾 明弘, 宮 秀俊, 黒田 良祐, 黒坂 昌弘

  (一社)日本関節鏡・膝・スポーツ整形外科学会, Jun. 2011, JOSKAS, 36(4) (4), 247 - 247, Japanese


• Comparison of the joint gap between before and after femoral component placement

  FUJIBAYASHI Isao

  25 Mar. 2011, JOSKAS, 36(1) (1), 102 - 103, Japanese


• 解剖学的二重束ACL再建術後のEndoButton経時的位置変化について―MDCTによる評価―

  岡真也, 黒田良祐, 松下雄彦, 長宗高樹, 荒木大輔, 久保晴司, 松本知之, 佐々木宏, 魚住洋佑, 伊藤あい, 黒坂昌弘

  25 Mar. 2011, 日本整形外科学会雑誌, 85(3) (3), S466, Japanese


• 骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上洋平, 川本篤彦, 伊井正明, 庄司太郎, 松本知之, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 244, Japanese


• Lnkの局所制御による,早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 川本篤彦, 伊井正明, 松本知之, 美舩泰, 福井友章, 黒田良祐, 高木智, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 226, Japanese


• ヌードラット大腿骨偽関節モデルに対するCD34陽性細胞および単核球の局所移植による治療効果の比較検討

  福井友章, 美舩泰, 松本知之, 庄司太郎, 川上洋平, 伊井正明, 川本篤彦, 黒田知也, 新倉隆弘, 黒坂昌弘, 黒田良祐, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 247, Japanese


• 培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療戦略

  川上洋平, 川本篤彦, 伊井正明, 庄司太郎, 松本知之, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 244, Japanese


• 伸展屈曲ギャップ差がPS‐TKAの術後早期成績に及ぼした影響について(Tensorを用いた定量的評価結果より)

  村津裕嗣, 長井寛斗, 篠原奈津代, 藏川拓外, 松本知之, 久保晴司, 圓尾明弘, 宮秀俊, 黒田良祐, 黒坂昌弘

  2011, 日本人工関節学会プログラム・抄録集, 41st, 213, Japanese


• 分子レベルからみた整形外科疾患(シリーズVIII) ヒト脂肪組織由来多能性幹細胞移植による難治性骨折治療

  Matsumoto Tomoyuki, Kuroda Ryosuke, Kurosaka Masahiro

  Jan. 2011, 整形・災害外科, 54巻, 1号, pp. 2-3, Japanese

  Introduction scientific journal


• 再生医療臨床研究の現状 各シーズの臨床研究進捗状況 骨軟骨 難治性骨折(偽関節)患者を対象とした自家末梢血CD34陽性細胞移植による骨・血管再生療法

  Kuroda Ryosuke, Kurosaka Masahiro, Matsumoto Tomoyuki

  Oct. 2010, 臨床評価, 38巻, 3号, pp. 584-588, Japanese

  Introduction scientific journal


• 軟骨再生 基礎と臨床 骨髄細胞による軟骨修復

  Kuroda Ryosuke, Matsumoto Tomoyuki, Kurosaka Masahiro

  Sep. 2010, 臨床整形外科, 45巻, 9号, pp. 797-800, Japanese

  Introduction scientific journal


• 体外増幅ヒトCD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上洋平, 庄司太郎, 松本知之, 美舩泰, 川本篤彦, 伊井正明, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  25 Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1083, Japanese


• 末梢血CD34陽性細胞による骨・血管再生療法

  松本知之, 美舩泰, 福井友章, 川上洋平, 三輪雅彦, 新倉隆宏, 李相亮, 大江啓介, 庄司太郎, 黒田知也, 川本篤彦, 浅原孝之, 黒坂昌弘, 黒田良祐

  25 Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1109, Japanese


• ラット大腿骨偽関節モデルにおけるG‐CSF動員CD34陽性細胞移植の治療効果の検討

  福井友章, 美舩泰, 松本知之, 庄司太郎, 川上洋平, 伊井正明, 川本篤彦, 黒田知也, 新倉隆宏, 三輪雅彦, 黒田良祐, 黒坂昌弘, 浅原孝之

  25 Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1083, Japanese


• 分子レベルからみた整形外科疾患(シリーズVIII) CD271陽性骨髄間質細胞を用いた軟骨再生

  Matsumoto Tomoyuki, Kuroda Ryosuke, Kurosaka Masahiro

  May 2010, 整形・災害外科, 53巻, 6号, pp. 674-675, Japanese

  Introduction scientific journal


• Effect of lateral patellar shift on soft tissue balance in mini-incision TKA

  OKA Shinya

  25 Mar. 2010, JOSKAS, 35(1) (1), 20 - 21, Japanese


• 末梢血CD34陽性細胞との共培養による骨折部血腫由来細胞の早期骨分化促進の検討

  康暁博, 李相亮, 三輪雅彦, 新倉隆宏, 古賀敬章, 松本知之, 大江啓介, 福井友章, 黒田良祐, 黒坂昌弘

  05 Feb. 2010, 再生医療, 9, 297, Japanese


• 培養増幅ヒト骨髄由来CD34陽性細胞のラット難治性骨折モデルにおける局所移植治療効果の検討

  川上洋平, 庄司太郎, 川本篤彦, 松本知之, 伊井正明, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 257, Japanese


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による骨折治療

  福井友章, 伊井正明, 美舩泰, 庄司太郎, 松本知之, 川上洋平, 黒田知也, 川本篤彦, 斎藤高志, 城潤一郎, 田畑康彦, 黒坂昌弘, 黒田良祐, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 298, Japanese


• ヒト骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上洋平, 庄司太郎, 川本篤彦, 松本知之, 伊井正明, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 296, Japanese


• 2A1-B16 The Development of "Flexible Drill" for Anterior Cruciate Ligament Reconstruction : Primary Investigation Using Prototype Mechanism

  KANO Kazuki, OKAMOTO Jun, MATSUMOTO Tomoyuki, KUBO Seiji, MURATSU Hirotsugu, KUROSAKA Masahiro, FUJIE Masakatsu G.

  In anterior cruciate ligament (ACL) reconstruction, bone tunnel construction is essential procedure, but there are risks of injuring lateral collateral ligament (LCL) and meniscus during the operation. Moreover, there is possibility that a graft is going to be damaged because of the friction in the vicinity of the edge of the tunnel. To solve these problems, we proposed the new "Flexible drill" which is able to make a curved bone tunnel. In this report, we made a prototype of new drill and verified the availability of our concept. In experimental result, the prototype realized cutting a curved bone tunnel with cancellous bone phantom made by Sawbones^[○!R]

  The Japan Society of Mechanical Engineers, 2010, ロボティクス・メカトロニクス講演会講演概要集, 2010, "2A1 - B16(1)"-"2A1-B16(3)", Japanese


• 高分子ハイドロゲルを用いた整形外科領域の再生医療研究

  黒田良祐, 久保晴司, 石田一成, 佐々木謙, 藤田周史, 松下雄彦, 松本知之, 田畑泰彦, 黒坂昌弘

  2010, 第32 回日本バイオマテリアル学会大会（2010.11.29－30 広島）, Japanese

  [Refereed]


• 生体吸収性ハイドロゲルを用いた顆粒球コロニー刺激因子（G-CSF）の局所徐放投与による骨再生

  石田一成, 黒田良祐, 松本知之, 藤田周史, 佐々木謙, 鄭克真, 久保晴司, 松下雄彦, 田畑泰彦, 黒坂昌弘

  2010, 38 回骨・カ ルシウム代謝研究会（2010.2.5 京都）, Japanese

  [Refereed]


• 特発性膝関節血症の2症例

  長井 寛斗, 黒田 良祐, 久保 晴司, 松本 知之, 松下 雄彦, 高山 孝治, 秋末 敏宏, 黒坂 昌弘

  (一社)中部日本整形外科災害外科学会, Nov. 2009, 中部日本整形外科災害外科学会雑誌, 52(6) (6), 1466 - 1467, Japanese


• 変形性膝関節症に対する第3世代ACI(Autologous Chondrocyte Implantation)を用いた治療

  黒田知也, 松本知之, 美舩泰, 福井友章, 久保晴司, 松下雄彦, 浅原孝之, 黒坂昌弘, 黒田良祐

  (公社)日本整形外科学会, 25 Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1312 - S1312, Japanese


• ラット大腿骨難治性骨折モデルに対するG‐CSF動員単核球細胞移植の治療効果の検討

  福井友章, 美舩泰, 松本知之, 川本篤彦, 黒田知也, 庄司太郎, 浅原孝之, 黒坂昌弘, 黒田良祐

  (公社)日本整形外科学会, 25 Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1238 - S1238, Japanese


• Identification and Characterization of Chondrogenic Progenitor Cells in Adult Skeletal Muscle

  Guangheng Li, Bo Zheng, Laura B. Meszaros, Joseph B. Vella, Karin A. Corsi, Arvydas Usas, Tomoyuki Matsumoto, Johnny Huard

  May 2009, MOLECULAR THERAPY, 17, S136 - S136, English

  Summary international conference


• 難治性骨折に対するG‐CSF動員単核球細胞移植の治療効果

  福井友章, 美舩泰, 松本知之, 川本篤彦, 黒田知也, 庄司太郎, 黒坂昌弘, 黒田良祐, 浅原孝之

  05 Feb. 2009, 再生医療, 8, 194, Japanese


• 骨折治癒過程におけるSDF‐1/CXCR4システムを介した血管内皮前駆細胞による骨・血管新生・再生の制御

  黒田知也, 櫂相模, 庄司太郎, 美舩泰, 福井友章, 松本知之, 松下雄彦, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2009, 再生医療, 8, 236, Japanese


• Idiopathic osteonecrosis of the second metatarsal head (vol 31, pg 431, 2007)

  Yutaka Mifune, Tomoyuki Matsumoto, Toshiyuki Mizuno, Shinichi Ikuta, Masahiro Kurosaka, Ryosuke Kuroda

  Mar. 2008, CLINICAL IMAGING, 32(2) (2), 164 - 164, English

  Others


• Acceleration of fracture healing via enhanced vasculogenesis and osteogenesis through SCF/cKit pathway in lnk-deficient mice

  T. Matsumoto, H. Nishimura, Y. Mifune, T. Shoji, R. Kuroda, A. Kawamoto, A. Oyamada, M. Horii, M. Miwa, M. Kurosaka, T. Asahara

  Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S235 - S235, English

  Summary international conference


• Local transplantation of G-CSF mobilized CD34-positive cells contributes to fracture healing

  Y. Mifune, T. Matsumoto, A. Kawamoto, R. Kuroda, T. Shoji, M. Miwa, K. Masahiro, T. Asahara

  Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S374 - S374, English

  Summary international conference


• 新しい医療技術 末梢血CD34陽性細胞による骨・血管再生療法の可能性

  松本 知之, 黒田 良祐, 美舩 泰

  金原出版, Aug. 2006, 整形・災害外科, 49(9) (9), 1009 - 1013, Japanese


• Long-term acceptance of fully MHC-mismatched limb allografts after a short course of anti-alpha beta-T cell receptor monoclonal antibody and FK506

  T Kanatani, M Lanzetta, T Matsumoto, H Fujioka, M Kurosaka, GA Bishop

  Jun. 2006, IMMUNOLOGY AND CELL BIOLOGY, 84(3) (3), A30 - A31, English

  Summary international conference


• 診断の指針 治療の指針 血管再生の現状と将来展望

  Matsumoto Tomoyuki, 浅原 孝之

  May 2006, 綜合臨床, 55(5号) (5号), 1529 - 1530, Japanese

  Introduction scientific journal


• 生体吸収性ゼラチンハイドロゲルと顆粒球コロニー刺激因子(G-CSF)を併用した前十字靭帯再建術

  佐々木謙, 黒田良祐, 石田一成, 鄭克真, 木下恵祐, 松本知之, 美舩泰, 黒坂昌弘, 田畑泰彦

  2006, 第9回日本組織工学会(2006.9.7-8 京都), Japanese

  [Refereed]


• 【ここまで進んだ幹細胞研究と再生医療2006 幹細胞の分化を運命づけるメカニズムから臨床応用の取り組み,産業化の展望まで】 幹細胞の臨床応用 ここまで来ている再生医療 血管内皮前駆細胞を用いた再生医療

  美舩 泰, Matsumoto Tomoyuki, 岩崎 弘登, 川本 篤彦, 浅原 孝之

  Jan. 2006, 実験医学, 24(2号) (2号), 234 - 240, Japanese

  Introduction scientific journal


• Anterior cruciate ligament injury-induced hemarthrosis of the knee as an alternative cell source for bone regeneration.

  S Lee, M Miwa, Y Sakai, R Kuroda, T Matsumoto, T Niikura, M Kurosaka

  Sep. 2005, JOURNAL OF BONE AND MINERAL RESEARCH, 20(9) (9), S360 - S361, English

  Summary international conference


• Administration of CD34-positive cells contributes to osteogenesis and vasculogenesis for functional bone healing

  T Matsumoto, A Kawamoto, R Kuroda, M Ishikawa, H Iwasaki, S Lee, A Oyamada, K Sadamoto, M Horii, H Nishimura, S Murasawa, M Kurosaka, T Asahara

  Sep. 2005, JOURNAL OF BONE AND MINERAL RESEARCH, 20(9) (9), S18 - S18, English

  Summary international conference


• Donor leukocytes combine with delayed immunosupressive drug therapy to induce long-term limb allograft survival

  T Kanatani, M Lanzetta, T Matsumoto, H Fujioka, M Kurosaka, GW McCaughan, GA Bishop

  Aug. 2005, IMMUNOLOGY AND CELL BIOLOGY, 83(4) (4), A9 - A9, English

  Summary international conference


• 【血管再生医工学】 血管内皮前駆細胞を用いた血管再生

  Matsumoto Tomoyuki, 川本 篤彦, 浅原 孝之

  Dec. 2004, 血管医学, 5(6号) (6号), 539 - 546, Japanese

  Introduction scientific journal


• Donor leukocytes combined with immunosupressive drug therapy to induce long-term acceptance of limb allografts

  T Kanatani, M Lanzetta, E Owen, GW McCaughan, T Matsumoto, GA Bishop

  Apr. 2004, IMMUNOLOGY AND CELL BIOLOGY, 82(2) (2), A11 - A12, English

  Summary international conference


• Stress fractures of the first rib in athletes : A report of two cases

  MATSUMOTO T., TSUNODA M., FUJITA K., FUJIOKA H., KUROSAKA M., MIZUNO K.

  01 May 2002, 骨折, 24(1) (1), 398 - 401, Japanese