Research activity information

• Nov. 2018 第63回日本口腔外科学会総会・学術大会, 優秀口演発表賞, 効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

  Hasegawa Takumi

  Japan society


• Sep. 2007 第37回日本口腔インプラント学会, 学会賞(デンツプライ賞)受賞, β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討

  Hasegawa Takumi

  Japan society

• Zymosan-Treated SKG Mice: Assessing Effects of Systemic Inflammation on the Temporomandibular Joint.

  Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi

  OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.

  Dec. 2024, Oral diseases, English, International magazine

  Scientific journal


• Relationship between bone union and degree of bone marrow fibrosis at resection margins of advanced mandibular ORN.

  Hiroaki Ohori, Eiji Iwata, Chihiro Ichikawa, Manabu Shigeoka, Yoshiaki Tadokoro, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  BACKGROUND: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome. METHODS: This study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. The extent of mandibulectomy was determined, with safety margins of approximately 10 mm from the apparent osteolytic areas on preoperative computed tomography image. Special staining was performed on thin sections from center of the osteolytic areas (medial area) and bilateral resection margins, and the degree of bone marrow fibrosis was evaluated and investigated its relationship with presence of bone union as a treatment outcome. RESULTS: The degree of bone marrow fibrosis of medial area was significantly higher than those of resection margins. Although most resection margins had collagen fibers which indicate severe fibrosis, all transferred fibula flaps achieved bone union. CONCLUSION: When mandibulectomy is performed with safety margins of approximately 10 mm from the apparent osteolytic areas, all transferred fibula flaps achieved bone union regardless of the degree of bone marrow fibrosis at resection margin. In other words, the association between severe bone marrow fibrosis at resection margins and treatment outcome was not seen. CLINICAL RELEVANCE: Setting safety margins of approximately 10 mm may achieve bone union, but further study is needed.

  Nov. 2024, Clinical oral investigations, 28(11) (11), 626 - 626, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The Radiographic Characteristics of Mandibular Wisdom Teeth That Can Cause Severe Deep Neck Infection.

  Eiji Iwata, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  PURPOSE: Mandibular wisdom teeth can occasionally cause infections, which can progress to severe deep neck infections (DNIs) including deep neck abscesses or necrotizing soft tissue infections, which are fatal. This study aimed to identify the radiographic characteristics of mandibular wisdom teeth that developed severe DNIs. METHODS: This study included patients who were admitted for the treatment of severe mandibular wisdom tooth infection between July 2012 and June 2024 at a single center. Patient characteristics, clinical data, and radiographic findings were analyzed and compared between the severe DNI group and mild DNI group including patients with cellulitis or superficial abscess. P < 0.05 was considered significant. RESULTS: Nineteen of 42 patients (45.2%) were included in the severe DNI group. The multivariate analysis showed that the highest odds ratio (OR) was for the presence of a radicular cyst (OR=17.7), followed by the presence of a dentigerous cyst (OR =14.5). The most common mandibular wisdom tooth with a dentigerous cyst in patients with severe DNIs was inverted according to Winter's classification and type IIIC in the Pell and Gregory classification. CONCLUSION: Radiographic characteristics associated with severe DNIs included the presence of radicular and dentigerous cysts in the mandibular wisdom teeth. Especially in dentigerous cysts, deeply impacted teeth should be taken attention.

  Oct. 2024, Cureus, 16(10) (10), e70791, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ヒト下歯槽神経のバリア制御に関連する分子の解析

  平岡 佑二郎, 松村 恵実, 筧 康正, 武田 大介, 重岡 学, 木本 明, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, Japanese


• 歯の喪失は65歳高齢者の早期要介護発生リスクと関係するか?

  筧 康正, 白井 達也, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 216 - 216, Japanese


• What Is the Appropriate Antibiotic Administration During Tooth Extractions in Patients Receiving High-Dose Denosumab?

  Eiji Iwata, Takumi Hasegawa, Hiroaki Ohori, Toshiya Oko, Tsutomu Minamikawa, Daisuke Miyai, Masaki Kobayashi, Naoki Takata, Shungo Furudoi, Junichiro Takeuchi, Kosuke Matsumoto, Akira Tachibana, Masaya Akashi

  PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) occasionally occurs following tooth extractions in cancer patients receiving denosumab (Dmab). However, there are currently no established guidelines for perioperative antibiotic administration during tooth extraction in these patients. The primary objective was to develop guidelines for the dose and frequency of antibiotics during tooth extraction by investigating the correlation between the current status of antibiotic administration and the development of MRONJ. METHODS: This study included 68 cancer patients receiving high-dose Dmab who had tooth extractions between 2012 and 2022 at 10 hospitals. The relationship between the way of perioperative antibiotic administration and the development of MRONJ was analyzed. A P-value < .05 was considered significant. RESULTS: There was considerable variability across hospitals and surgeons regarding the type, dosage, and duration of antibiotic administration. Amoxicillin (AMPC) was the most commonly used antibiotic. Focusing exclusively on teeth extracted under AMPC administration, MRONJ developed in 21 out of 123 teeth (17.0%). No significant relationship was found between the development of MRONJ and the dosage or duration of perioperative AMPC administration. CONCLUSION: Perioperative antibiotic administration alone may not be sufficient to prevent MRONJ. Therefore, a single preoperative dose is likely adequate for effective and appropriate AMPC administration. .

  Aug. 2024, Cureus, 16(8) (8), e67237, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study

  Nobuhiro Yamakawa, Masaya Okura, Takumi Hasegawa, Mitsunobu Otsuru, Hironori Sakai, Eiji Hirai, Shin Rin, Shin-ichi Yamada, Souichi Yanamoto, Yusuke Yokota, Masahiro Umeda, Hiroshi Kurita, Michihiro Ueda, Masaya Akashi, Tadaaki Kirita

  Springer Science and Business Media LLC, May 2024, International Journal of Clinical Oncology, 29(8) (8), 1122 - 1132

  Scientific journal


• Efficacy of perioperative oral care management in the prevention of surgical complications in 503 patients after pancreaticoduodenectomy for resectable malignant tumor: A multicenter retrospective analysis using propensity score matching

  Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin ichi Yamada, Hirokazu Nakahara

  Apr. 2024, Surgery (United States), 175(4) (4), 1128 - 1133

  Scientific journal


• Efficacy of perioperative oral care management in the prevention of surgical complications in 503 patients after pancreaticoduodenectomy for resectable malignant tumor: A multicenter retrospective analysis using propensity score matching.

  Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin-Ichi Yamada, Hirokazu Nakahara

  BACKGROUND: Pancreaticoduodenectomy has been associated with a high mortality rate and significant postoperative morbidity. Recently, perioperative oral care management has been reported to be effective in preventing postoperative pneumonia and surgical site infection. In this study, we examined the effect of perioperative oral care management in reducing complications after pancreaticoduodenectomy, including surgical site infection. METHODS: This retrospective multicenter study included 503 patients who underwent pancreaticoduodenectomy at 8 facilities between January 2014 and December 2016. Among these, 144 received perioperative oral management by dentists and dental hygienists (oral management group), whereas the remaining 359 did not (control group). The oral care management program included oral health instructions, removal of dental calculus, professional mechanical tooth cleaning, removal of tongue coating, denture cleaning, instructions for gargling, and tooth extraction. The participants were matched using propensity scores to reduce background bias. Various factors were examined for correlation with the development of complications. RESULTS: The incidence of organ/space surgical site infection was significantly lower in the oral management group than in the control group (8.0% vs 19.6%, P = .005). Multivariable logistic regression analysis revealed that hypertension and lack of perioperative oral management were independent risk factors for organ/space surgical site infection. Lack of perioperative oral management had an odds ratio of 2.847 (95% confidence interval 1.335-6.071, P = .007). CONCLUSION: Perioperative oral care management reduces the occurrence of surgical site infections after pancreaticoduodenectomy and should be recommended as a strategy to prevent infections in addition to antibiotic use.

  Apr. 2024, Surgery, 175(4) (4), 1128 - 1133, English, International magazine

  Scientific journal


• Assessment of Patient Characteristics Influencing the Analgesic Effects of Ibuprofen Gargle After Mandibular Third Molar Extractions.

  Yasumasa Kakei, Takeshi Ioroi, Keiko Miyakoda, Takahiro Ito, Masahiko Kashin, Tatsuya Shirai, Takumi Hasegawa, Toshiyasu Sakane, Ikuko Yano, Masaya Akashi

  Introduction In our previous work, we investigated the analgesic effects of ibuprofen gargle after mandibular third molar extractions. However, a subsequent detailed review of individual patient data revealed variations in postoperative pain reduction among patients. Consequently, the present study was designed to conduct post-hoc subanalyses that identified factors contributing to variation in the analgesic response to ibuprofen gargle after third molar extractions. Materials and methods This study involved thirty-five Japanese patients from a prior randomized, double-blind, placebo-controlled, crossover study, which focused on the analgesic effects of ibuprofen gargle after mandibular third molar extractions. Participants were categorized as responders (n = 13) and non-responders (n = 22) based on the within-subject difference (ibuprofen-placebo, IP) of visual analog scale (VAS) changes. Baseline characteristics were compared, along with variables, such as age, sex, the reason for extraction, extraction site, Pell Gregory (space and depth) classification, Winter's classification, surgeon's experience, and surgery time. Baseline characteristics predicting responder status were examined using multivariate logistic regression. Results In the univariate analysis, variables such as age, sex, and baseline VAS scores with p-values <0.2 were evaluated using a stepwise approach. This analysis identified age (per -10 years) with an odds ratio of 4.163 (95% confidence interval (CI): 1.170-31.952, p = 0.0233) and sex (female) with an odds ratio of 9.977 (95% CI: 1.336-208.256, p = 0.0213) as significant predictors of responder status. Conclusions In young and female patients, ibuprofen gargle decreased postoperative pain after mandibular third molar extractions.

  Apr. 2024, Cureus, 16(4) (4), e57516, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

  Aki Sasaki, Daisuke Takeda, Hotaka Kawai, Yoshiaki Tadokoro, Aki Murakami, Nanae Yatagai, Satomi Arimoto, Hitoshi Nagatsuka, Masaya Akashi, Takumi Hasegawa

  Cancer cachexia causes skeletal muscle atrophy, impacting the treatment and prognosis of patients with advanced cancer, but no treatment has yet been established to control cancer cachexia. We demonstrated that transcutaneous application of carbon dioxide (CO2) could improve local blood flow and reduce skeletal muscle atrophy in a fracture model. However, the effects of transcutaneous application of CO2 in cancer-bearing conditions are not yet known. In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, the quadriceps were extracted, and muscle atrophy markers (muscle atrophy F-box protein (MAFbx), muscle RING-finger protein 1 (MuRF-1)) and uncoupling protein markers (uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3)) were evaluated by real-time polymerase chain reaction and immunohistochemical staining, and CSA by hematoxylin and eosin staining. The CO2-treated group exhibited significant mRNA and protein expression inhibition of the four markers. Furthermore, immunohistochemical staining showed decreased MAFbx, MuRF-1, UCP2, and UCP3 in the CO2-treated group. In fact, the CSA in hematoxylin and eosin staining and the FFM revealed significant suppression of skeletal muscle atrophy in the CO2-treated group. We suggest that transcutaneous application of CO2 to skeletal muscle suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

  2024, PloS one, 19(4) (4), e0302194, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Is withdrawal of antiresorptive agents necessary before and after tooth extraction? A systematic review.

  Daisuke Takeda, Hiroshi Kurita, Yoshihisa Kashima, Takumi Hasegawa, Masaaki Miyakoshi, Shin-Ichi Yamada, Yoshiko Yamamura, Sakiko Soutome

  OBJECTIVES: The need for prevention and management of medication-related osteonecrosis of the jaw (MRONJ) has increased with the growing number of patients using antiresorptive agents. The scope of this systematic review (SR) was to determine whether the withdrawal of antiresorptive agents is necessary for tooth extractions in patients receiving each of the antiresorptive medications. MATERIALS AND METHODS: The searches were performed using the MEDLINE databases. We selected SRs, randomized controlled trials (RCTs), prospective and retrospective non-randomized clinical (observational) studies, and case reports/case series in this order of preference. RESULTS: We included one SR, one RCT, five observational studies, and three case reports. Meta-analyses were not conducted because the RCT had an extremely small sample size and the observational studies had different definitions of intervention and comparison that could not be integrated across studies. In this SR, no studies showed a benefit (i.e., a reduction in the incidence of osteonecrosis of the jaw) of short-term withdrawal of antiresorptive agents for tooth extraction. Additionally, no studies examined the harm (i.e., an increase in femoral and vertebral fractures and skeletal-related events during bone metastasis) of withdrawal for tooth extraction. CONCLUSIONS: We were unable to determine whether withdrawal before and after tooth extraction is necessary with a high certainty of evidence. Future systematic reviews including RCTs with larger samples are expected to provide such evidence. CLINICAL RELEVANCE: This systematic review provides evidence-based information for multidisciplinary collaborations related to patients receiving antiresorptive agents.

  Dec. 2023, Clinical oral investigations, 28(1) (1), 38 - 38, English, International magazine

  Scientific journal


• Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo

  Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi

  Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.

  MDPI AG, Dec. 2023, Cancers, 15(23) (23), 5697 - 5697

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Tooth Loss as a Predictor of Long-Term Care Requirements in the Elderly: A Study in Kobe City, Japan

  Yasumasa Kakei, Tatsuo Kagimura, Yasuji Yamamoto, Tohmi Osaki, Hiroyuki Kajita, Shinsuke Kojima, Hisatomo Kowa, Miyuki Kawabata, Takumi Hasegawa, Masaya Akashi, Yoji Nagai

  Dec. 2023, Cureus, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Detection of bone marrow edema in differential diagnoses of odontogenic cysts using dual-energy computed tomography.

  Takumi Hasegawa, Satomi Arimoto, Izumi Saito, Nanae Yatagai, Aki Murakami, Aki Sasaki, Yoshiaki Tadokoro, Wakiko Tani, Kiyosumi Kagawa, Masaya Akashi

  PURPOSE: In this study, we prospectively investigated the relationship between bone marrow edema (BME) and odontogenic cysts and explored the possibility of using dual-energy computed tomography (DECT) as an auxiliary tool for the diagnosis of odontogenic cysts. METHODS: This cross-sectional study included 73 patients who underwent the DECT scan and surgery for odontogenic cysts or odontogenic tumors. The virtual noncalcium (VNCa) computed tomography (CT) values and CT values were measured at several sites. The predictor variable was diagnosis, and the other variables included age, sex, and sites. The primary outcome was VNCa CT value. Variables were tested using the chi-square test or the Kruskal-Wallis test. The VNCa CT and CT values were tested using the Scheffe test for multiple comparisons. All variables were analyzed as independent variables affecting the VNCa CT values around the lesion in the multiple regression analysis. RESULT: There were 35 men and 38 women. The mean patient age was 50.0 ± 19.5 years (range: 8-86). The VNCa CT values (- 6.2 ± 34.3) around the lesion in patients with RCs were significantly higher than those in patients with dentigerous cysts (- 44.4 ± 28.6) and odontogenic keratocysts (- 67.3 ± 19.5). In multiple regression analysis, the VNCa CT values around the lesion showed a significant positive correlation with histological results (regression coefficient: - 0.605, P < 0.001). CONCLUSION: The presence of BME is associated with radicular cysts, and DECT can be used as an auxiliary tool for radicular cyst diagnosis.

  Dec. 2023, Oral and maxillofacial surgery, 27(4) (4), 675 - 684, English, International magazine

  Scientific journal


• 下顎歯肉癌腓骨皮弁再建症例におけるインプラント支持型圧迫床を用いた前庭拡張術の工夫

  高木 ひかる, 筧 康正, 白井 達也, 長谷川 巧実

  (公社)日本口腔インプラント学会, Dec. 2023, 日本口腔インプラント学会誌, 36(4) (4), E206 - E207, Japanese


• Efficacy and safety of ibuprofen gargle for postoperative pain after mandibular third molar extraction: A phase II, placebo-controlled, double-blind, randomized crossover trial.

  Takeshi Ioroi, Yasumasa Kakei, Takahiro Ito, Tatsuya Shirai, Yutaro Okazaki, Takumi Hasegawa, Masaya Akashi, Ikuko Yano

  OBJECTIVE: This study was designed to evaluate the postoperative efficacy and safety of using an ibuprofen gargle as a pain management strategy for patients who have undergone mandibular third molar extraction. We also ensured that the quality of treatment was not compromised throughout the study. MATERIAL AND METHODS: Patients were randomized in a 1:1 ratio into two groups: the ibuprofen-placebo (IP) group and the placebo-ibuprofen (PI) group. On postoperative Day (POD) 1, the IP group initiated ibuprofen administration, while the PI group started taking placebo. On POD 2, the IP group switched to using placebo, whereas the PI group switched to ibuprofen. From PODs 3-5, both groups were prescribed ibuprofen gargle. The primary endpoint was within-subject visual analog scale (VAS) score before and 5 min after the first use of the ibuprofen or placebo gargle on PODs 1 and 2 (ΔVAS5_ibuprofen  - ΔVAS5_placebo ). The incidence and severity of adverse events were assessed using the Common Terminology Criteria for Adverse Events version 5.0 and a subjective rating scale. RESULTS: This study enrolled 40 patients. The within-subject VAS5 of the IP and PI groups were 1.25 ± 12.0 and -5.26 ± 8.93 mm, respectively. The treatment effect of ibuprofen gargle was -2.01 ± 10.62 mm (p = .246). None of the patients in each group presented with serious adverse events or clinically significant complications (including dry sockets) after extraction. Transient adverse events, such as throat tingling and oral discomfort (grade 1), were observed in each group. CONCLUSION: Ibuprofen gargle was safe but did not provide significant pain relief when used after mandibular third molar extraction.

  Nov. 2023, Clinical and experimental dental research, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors associated with prognosis of patients with medication-related osteonecrosis of the jaw.

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Satomi Arimoro, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive and/or antiangiogenic agents. As the treatment application for MRONJ is controversial, we aimed to identify the risk factors for poor prognosis and to help determine appropriate management. METHODS: This study included 119 patients. Relevant clinical data were obtained for all the patients. In computed tomography images, osteosclerosis, osteolysis, cortical perforation (buccal or lingual), periosteal reaction, and sequestration were evaluated. RESULTS: Multivariate analyses showed statistically significant associations between poor prognosis in patients with MRONJ and conservative treatment alone (hazard ratio [HR] 1.89), osteolysis (HR 4.67), and the absence of sequestration (HR 5.33). CONCLUSIONS: Conservative treatment alone without clear objectives needs to be avoided, and osteolytic change could be the criteria for surgical intervention. As the boundary between the lesion and vital bone is indistinct, we recommend extensive surgery in cases with unpredictable sequestration.

  Nov. 2023, Head & neck, English, International magazine

  Scientific journal


• The Efficacy of Carbon Dioxide Paste in Alleviating Pain in Patients After Neck Dissection: Protocol for a Double-Blinded, Randomized Controlled Trial.

  Yoshiaki Tadokoro, Daisuke Takeda, Izumi Saito, Nanae Yatagai, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  BACKGROUND: Head and neck cancers that cause severe aesthetic and functional disorders normally metastasize to the cervical lymph nodes. Patients with cervical lymph node metastasis are undergoing neck dissection. Shoulder complaints are common after neck dissection, with patients reporting symptoms such as pain, weakness, shoulder droop, and disability. However, no safe and effective treatment is available for this condition at present. We will conduct a double-blinded, randomized controlled trial to evaluate the efficacy of carbon dioxide (CO2) paste in relieving pain in patients after neck dissection. OBJECTIVE: This will be the first clinical study to compare the efficacy of CO2 paste with placebo in relieving postoperative pain in patients who underwent neck dissection. METHODS: We will perform this trial at the Kobe University Hospital in Japan. Patients will be randomized 1:1 into the CO2 paste and control groups. Patients in the CO2 paste group will have the CO2 paste applied to the cervical surface skin for 10 minutes once per day for 14 consecutive days. The primary end point of the study is a change in the visual analog scale (VAS) scores of neck pain from baseline on day 1 (preapplication) to the end of drug application (day 15). Secondary end points include changes in the following parameters from baseline on day 1 to the end of drug application (day 15) or the study (day 29): neck pain VAS score (days 1-29), grip strength (days 1-15 and 1-29), VAS scores for subjective symptoms (the feeling of strangulation, numbness, swelling, and warmth in the neck and shoulder region) for days 1-15 and 1-29, whether the VAS score improved more than 30% (days 1-15), the arm abduction test (days 1-15 and 1-29), shoulder range of motion (abduction and flexion) for days 1-15 and 1-29, occurrence of skin disorders, and occurrence of serious side effects. Periodic monitoring will be conducted for participants during the trial. This study was approved by the certified review board of Kobe University. RESULTS: The intervention commenced in May 2021 and will continue until March 2024. The collected data will provide information on the efficacy of the CO2 paste treatment. The primary end point will be compared using the Wilcoxon test, with the 1-sided significance level set at 5%. Each evaluation item will be summarized. Secondary efficacy end points will be analyzed to provide additional insights into the primary analysis. Findings based on the treatment effects are expected to be submitted for publication in 2025. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of CO2 paste in relieving pain in patients after neck dissection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) identifier: jRCTs051210028; https://jrct.niph.go.jp/en-latest-detail/jRCTs051210028. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/50500.

  Nov. 2023, JMIR research protocols, 12, e50500, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Development of Cu application using dual-energy computed tomography for detecting medication-related osteonecrosis of the jaw.

  Kazuki Shigenaga, Satomi Arimoto, Masahiro Kubo, Takumi Sato, Yujiro Hiraoka, Daisuke Takeda, Takumi Hasegawa, Kiyosumi Kagawa, Masaya Akashi

  INTRODUCTION: The present study developed an application using dual-energy computed tomography (DECT) focused on Cu for detecting medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: First, we performed two types of phantom studies using a Cu wire syringe and pig mandible with Cu wire to detect Cu on DECT. Second, DECT examinations of 44 patients with MRONJ were performed to compare lesion and normal bone sites using single-energy CT, DECT-virtual non-calcium (VNCa), and DECT-Cu applications. Quantitative analyses of VNCa CT and CT values were performed, and a cut-off value was calculated using receiver operating characteristic analysis. Third, we compared the Cu content in the MRONJ and normal bone groups using inductively coupled plasma atomic emission spectroscopy (ICP-AES). RESULTS: The material-specific differences in attenuation between the two different energies enabled the accurate separation of Cu from Ca in phantom studies. The sensitivity and specificity for single-energy CT, DECT-VNCa, and DECT-Cu applications were 97.7% and 2.3%, 86.4% and 81.8%, and 88.6% and 97.7%, respectively. Thus, VNCa CT values obtained on DECT-Cu application images showed the highest area under the curve value and maximal diagnostic efficacy in differentiating lesion sites from normal bone sites. On ICP-AES analyses, the Cu content was significantly higher in the MRONJ group than in the normal bone group. CONCLUSION: DECT-Cu application demonstrated better diagnostic performance in detecting MRONJ compared with single-energy CT or DECT-VNCa.

  Nov. 2023, Journal of bone and mineral metabolism, 41(6) (6), 865 - 876, English, Domestic magazine

  Scientific journal


• 当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例

  高木 ひかる, 筧 康正, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2023, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, Japanese


• Photodynamic therapy with verteporfin accelerates apoptotic bleb formation in human ameloblastoma.

  Junya Yamashita, Akira Kimoto, Shun Teraoka, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Manabu Shigeoka, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.

  Oct. 2023, Oral diseases, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Correction to: Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study (Osteoporosis International, (2021), 32, 11, (2323-2333), 10.1007/s00198-021-05995-3)

  T. Hasegawa, N. Ueda, Si Yamada, S. Kato, E. Iwata, S. Hayashida, Y. Kojima, M. Shinohara, I. Tojo, H. Nakahara, T. Yamaguchi, T. Kirita, H. Kurita, Y. Shibuya, S. Soutome, M. Akashi

  Oct. 2023, Osteoporosis International, 34(10) (10), 1823 - 1825

  Scientific journal


• Comparison of the 8th edition of TNM staging of oral cancer with the 7th edition and its prognostic significance using clinical depth of invasion and extranodal extension

  Yusuke Yokota, Takumi Hasegawa, Nobuhiro Yamakawa, Shin Rin, Mitsunobu Otsuru, Shin-ichi Yamada, Eiji Hirai, Yuichi Ashikaga, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masahiro Umeda, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Souichi Yanamoto, Masaya Okura

  Elsevier BV, Oct. 2023, Oral Oncology, 145, 106519 - 106519

  Scientific journal


• Correction: Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?

  Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  Sep. 2023, Journal of bone and mineral metabolism, 41(5) (5), 652 - 653, English, Domestic magazine


• Effect of Frequent Computed Tomography Examinations with Contrast Media on the Renal Function of Patients with Oral Squamous Cell Cancer and an Evaluation of Risk Factors for Post-Operative Chronic Kidney Disease

  Takumi Hasegawa, Aya Matsuda, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  Sep. 2023, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship of Mitochondrial-Related Protein Expression with the Differentiation, Metastasis, and Poor Prognosis of Oral Squamous Cell Carcinoma.

  Aki Murakami, Daisuke Takeda, Junya Hirota, Izumi Saito, Rika Amano-Iga, Nanae Yatagai, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation and progression of cancer. The purpose of this study was to retrospectively investigate the expression of mitochondrial tumor-suppressor and DNA-repair proteins in patients with oral squamous cell carcinoma (OSCC) and to evaluate the relationship between their expression and prognosis. We enrolled 197 patients with OSCC who underwent surgical resection between August 2013 and October 2018. Clinical, pathological, and epidemiological data were retrospectively collected from hospital records. The expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), mitochondrial transcription factor A, mitochondrial tumor suppressor gene 1, silent information regulator 3, and 8-hydroxyguanine DNA glycosylase was investigated using immunochemistry. The 3-year disease-specific survival (DSS) rates of patients showing positive expression of all selected proteins were significantly higher than those of patients showing a lack of expression. Multivariate analysis revealed that the expression of PGC-1α (hazard ratio, 4.684) and vascular invasion (hazard ratio, 5.690) can predict the DSS rate (p < 0.001). Low PGC-1α expression and vascular invasion are potential clinically effective predictors of the prognosis of OSCC.

  Aug. 2023, Cancers, 15(16) (16), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Author Correction: Risk factors for pathological fracture in patients with mandibular osteoradionecrosis.

  Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  Jul. 2023, Scientific reports, 13(1) (1), 11216 - 11216, English, International magazine


• A Novel Imaging Technique for Analyzing Condylar Movement During Mastication in Patients With Jaw Deformities: Four-Dimensional Computed Tomography.

  Akira Kimoto, Junya Yamashita, Hiroaki Ohori, Noriyuki Negi, Toshinori Sekitani, Hiroki Komori, Atsushi Shioyasono, Chizu Tateishi, Takumi Hasegawa, Masaya Akashi

  OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.

  Jul. 2023, The Journal of craniofacial surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• OHATスコアは膿胸患者の3ヵ月時死亡リスク評価に有用である 傾向スコアマッチング法を用いた後ろ向き観察研究

  岩田 英治, 橘 進彰, 八谷 奈苗, 松井 太輝, 楠元 順哉, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 158 - 158, Japanese


• 経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果

  廣田 純也, 長谷川 巧実, 伊賀 利香, 八谷 奈苗, 黒澤 泉, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, Japanese


• Expression of JCAD and EGFR in Perineurial Cell-Cell Junctions of Human Inferior Alveolar Nerve.

  Yujiro Hiraoka, Megumi Matsumura, Yasumasa Kakei, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Masaya Akashi

  Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.

  Jun. 2023, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Is the LRINEC score useful for predicting necrotizing fasciitis as a complication of MRONJ?

  Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  INTRODUCTION: Necrotizing fasciitis as a complication of medication-related osteonecrosis of the jaw (MRONJ), which we named "ONJ-NF", has been sometimes reported. This study aimed to investigate the usefulness of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for predicting ONJ-NF. MATERIALS AND METHODS: We included patients with acute MRONJ who required hospitalization at a single institution from April 2013 to June 2022. They were divided into two groups: patients with ONJ-NF and those with severe cellulitis as a complication of MRONJ, which we named "ONJ-SC." LRINEC scores were compared between the groups and the cut-off value of the score was set by creating a receiver operating characteristic curve. RESULTS: Eight patients with ONJ-NF and 22 patients with ONJ-SC were included. The LRINEC score was significantly higher in patients with ONJ-NF (median: 8.0 points, range 6-10 points) than in those with ONJ-SC (median: 2.5 points, range 0-6 points). A LRINEC score of ≥ 6 points had a sensitivity of 100.0%, a specificity of 77.3%, and an area under the curve of 0.97. Among 6 parameters of LRINEC score, only C-reactive protein (CRP) and white blood cell count (WBC) had significant differences between two groups. Most of the patients with ONJ-NF were rescued by antibiotic therapy and surgical drainage including debridement of necrotic tissues, but unfortunately, one patient did not survive. CONCLUSION: Our results suggested that the LRINEC score may be a useful diagnostic tool to predict ONJ-NF but valuating only CRP and WBC may be sufficient particularly in patients with osteoporosis.

  Jun. 2023, Journal of bone and mineral metabolism, English, Domestic magazine

  Scientific journal


• ステージ1-2舌癌におけるT分類第8版の妥当性の検証と後発頸部リンパ節転移の予測因子

  船原 隆一郎, 古川 浩平, 松井 太輝, 長谷川 巧実, 梅田 正博, 明石 昌也

  (公社)日本口腔外科学会, May 2023, 日本口腔外科学会雑誌, 69(5) (5), 233 - 240, Japanese


• 当科で新型コロナウイルス感染症に対してPCR検査を行った患者についての考察

  利川 誠将, 武田 大介, 長谷川 巧実, 明石 昌也

  (一社)日本口腔感染症学会, May 2023, 日本口腔感染症学会雑誌, 30(1) (1), 65 - 66, Japanese


• 歯科衛生士が口腔衛生管理を行った患者に対するCOVID-19発症状況について

  岡崎 葉菜, 武田 大介, 片山 めぐみ, 西井 美佳, 村木 友美, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2023, 日本口腔ケア学会雑誌, 17(3) (3), 172 - 172, Japanese


• COVID-19感染が契機と考えられたスティーブンスジョンソン症候群患者への口腔衛生管理の1例

  片山 めぐみ, 村木 友美, 岡崎 葉菜, 西井 美佳, 武田 大介, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2023, 日本口腔ケア学会雑誌, 17(3) (3), 229 - 229, Japanese


• Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine-induced rat model of muscle injury

  Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi

  Apr. 2023, INTERNATIONAL WOUND JOURNAL, 20(4) (4), 1151 - 1159, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Local application of a transcutaneous carbon dioxide paste prevents excessive scarring and promotes muscle regeneration in a bupivacaine-induced rat model of muscle injury.

  Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi

  In postoperative patients with head and neck cancer, scar tissue formation may interfere with the healing process, resulting in incomplete functional recovery and a reduced quality of life. Percutaneous application of carbon dioxide (CO2 ) has been reported to improve hypoxia, stimulate angiogenesis, and promote fracture repair and muscle damage. However, gaseous CO2 cannot be applied to the head and neck regions. Previously, we developed a paste that holds non-gaseous CO2 in a carrier and can be administered transdermally. Here, we investigated whether this paste could prevent excessive scarring and promote muscle regeneration using a bupivacaine-induced rat model of muscle injury. Forty-eight Sprague Dawley rats were randomly assigned to either a control group or a CO2 group. Both groups underwent surgery to induce muscle injury, but the control group received no treatment, whereas the CO2 group received the CO2 paste daily after surgery. Then, samples of the experimental sites were taken on days 3, 7, 14, and 21 post-surgery to examine the following: (1) inflammatory (interleukin [IL]-1β, IL-6), and transforming growth factor (TGF)-β and myogenic (MyoD and myogenin) gene expression by polymerase chain reaction, (2) muscle regeneration with haematoxylin and eosin staining, and (3) MyoD and myogenin protein expression using immunohistochemical staining. Rats in the CO2 group showed higher MyoD and myogenin expression and lower IL-1β, IL-6, and TGF-β expression than the control rats. In addition, treated rats showed evidence of accelerated muscle regeneration. Our study demonstrated that the CO2 paste prevents excessive scarring and accelerates muscle regeneration. This action may be exerted through the induction of an artificial Bohr effect, which leads to the upregulation of MyoD and myogenin, and the downregulation of IL-1β, IL-6, and TGF-β. The paste is inexpensive and non-invasive. Thus, it may be the treatment of choice for patients with muscle damage.

  Apr. 2023, International wound journal, 20(4) (4), 1151 - 1159, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for pathological fracture in patients with mandibular osteoradionecrosis.

  Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi

  Osteoradionecrosis (ORN) often results in pathological fractures through progression. We aimed to identify the risk factors for pathological fracture in patients with mandibular ORN. Seventy-four patients with mandibular ORN were included in this retrospective study. We investigated various risk factors for pathological fracture in patients with mandibular ORN, including number of mandibular teeth with a poor prognosis each at initial evaluation before radiation therapy (RT) and when fracture occurred, and the proportion of antibiotic administration period in a follow-up duration after RT. The rate of occurrence of pathological fractures in patients with mandibular ORN was 25.7%. The median of duration between RT completion and fracture occurrence was 74.0 months. We found that pathological fracture was significantly associated with a larger number of mandibular teeth with a poor prognosis at initial evaluation before RT (P = 0.024) and when fracture occurred (P = 0.009). Especially, a larger number of mandibular teeth with P4 periodontitis, in other words severe periodontal status, was related to pathological fracture in both timings. The proportion of antibiotic administration period in a follow-up duration was also significant risk factor (P = 0.002). Multivariate analyses showed statistically significant associations between pathological fracture and a larger number of mandibular teeth with a poor prognosis when fracture occurred (hazard ratio 3.669). The patient with a larger number of mandibular teeth with P4 periodontitis may have a risk of not only occurrence of ORN but resulting in pathological fracture by accumulation of infection. Surgeons should consider extraction of those teeth regardless of before/after RT if necessary for infection control.

  Apr. 2023, Scientific reports, 13(1) (1), 5367 - 5367, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Multicenter retrospective study of the prognosis and the effect of postoperative adjuvant therapy in Japanese oral squamous cell carcinoma patients with close margin.

  Takumi Hasegawa, Yasumasa Kakei, Nobuhiro Yamakawa, Tadaaki Kirita, Masaya Okura, Tomofumi Naruse, Mitsunobu Otsuru, Shin-Ichi Yamada, Hiroshi Kurita, Eiji Hirai, Shin Rin, Michihiro Ueda, Masahiro Umeda, Masaya Akashi

  BACKGROUND: The purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN- and pN+ groups. METHODS: The evaluated endpoints were local control and disease-specific survival (DSS) rates. RESULTS: Higher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN- groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3-year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%). CONCLUSIONS: Higher T classification and LVSI are high-risk features more than PM or CM in the pN- groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.

  Mar. 2023, Head & neck, 45(6) (6), 1418 - 1429, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy and Long-Term Safety of Ibuprofen Gargle for Oral Lichen Planus: A Study Protocol of Randomized Crossover and Long-Term Extension Trials

  Yumi Kitahiro, Takeshi Ioroi, Yasumasa Kakei, Junya Yamashita, Akira Kimoto, Takumi Hasegawa, Asami Morioka, Kazuhiro Yamamoto, Masaya Akashi, Ikuko Yano

  Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.

  MDPI AG, Jan. 2023, Methods and Protocols, 6(1) (1), 7 - 7

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide application suppresses the expression of cancer-associated fibroblasts markers in oral squamous cell carcinoma xenograft mouse model.

  Yoshiaki Tadokoro, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa

  Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumor microenvironment (TME). As CAFs promote tumor progression and hypoxia in the TME, regulating the conversion of normal fibroblasts (NFs) into CAFs is essential for improving the prognosis of patients with OSCC. We have previously reported the antitumor effects of transcutaneous carbon dioxide (CO2) application in OSCC. However, the effects of reducing hypoxia in the TME remain unclear. In this study, we investigated whether CO2 administration improves the TME by evaluating CAFs marker expression. Human OSCC cells (HSC-3) and normal human dermal fibroblasts (NHDF) were coinjected subcutaneously into the dorsal region of mice. CO2 gas was applied twice a week for 3 weeks. The tumors were harvested six times after transcutaneous CO2 application. The expression of CAFs markers (α-SMA, FAP, PDPN, and TGF-β) were evaluated by using real-time polymerase chain reaction and immunohistochemical staining. The expression of α-SMA, FAP, PDPN, and TGF-β was significantly increased over time after co-injection. In the CO2-treated group, tumor growth was significantly suppressed after treatment initiation. In addition, the mRNA expression of these markers was significantly inhibited. Furthermore, immunohistochemical staining revealed a significant decrease in the protein expression of all CAFs markers in the CO2-treated group. We confirmed that transcutaneous CO2 application suppressed CAFs marker expression and tumor growth in OSCC xenograft mouse model.

  2023, PloS one, 18(8) (8), e0290357, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between oral health and prognosis in patients with empyema: Single center retrospective study with propensity score matching analysis.

  Eiji Iwata, Teruaki Nishiuma, Suya Hori, Keiko Sugiura, Masato Taki, Shuntaro Tokunaga, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi

  BACKGROUND: Empyema is a life-threatening infection often caused by oral microbiota. To the best of our knowledge, no reports have investigated the association between the objective assessment of oral health and prognosis in patients with empyema. MATERIALS AND METHODS: A total of 63 patients with empyema who required hospitalization at a single institution were included in this retrospective study. We compared non-survivors and survivors to assess risk factors for death at three months, including the Renal, age, pus, infection, diet (RAPID) score, and Oral Health Assessment Tool (OHAT) score. Furthermore, to minimize the background bias of the OHAT high-score and low-score groups determined based on the cut-off value, we also analyzed the association between the OHAT score and death at 3 months using the propensity score matching method. RESULTS: The 3-month mortality rate was 20.6% (13 patients). Multivariate analysis showed that a RAPID score ≥5 points (odds ratio (OR) 8.74) and an OHAT score ≥7 points (OR 13.91) were significantly associated with death at 3 months. In the propensity score analysis, a significant association was found between a high OHAT score (≥7 points) and death at 3 months (P = 0.019). CONCLUSION: Our results indicated that oral health assessed using the OHAT score may be a potential independent prognostic factor in patients with empyema. Similar to the RAPID score, the OHAT score may become an important indicator for the treatment of empyema.

  2023, PloS one, 18(3) (3), e0282191, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• ASO Visual Abstract: A Multicenter Study on the Distance of Closed Margin in Stage 1-2 Squamous Cell Carcinoma of the Tongue.

  Mitsunobu Otsuru, Takumi Hasegawa, Nobuhiro Yamakawa, Masaya Okura, Shin-Ichi Yamada, Eiji Hirai, Toru Inomata, Hirokazu Saito, Kei-Ichiro Miura, Kouhei Furukawa, Satoshi Naruse, Souichi Yanamoto, Masahiro Umeda

  Nov. 2022, Annals of surgical oncology, English, International magazine

  Scientific journal


• 当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究

  早瀬 悠夏, 長谷川 巧実, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 筧 康正, 木本 明, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2022, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, Japanese


• Perioperative bridging anticoagulation in patients with oral cancer surgery: a multicenter retrospective study

  Ryo Kajihara, Shin ichi Yamada, Takumi Hasegawa, Hitoshi Yoshimura, Hidetake Tachinami, Kei Tomihara, On Hasegawa, Sumiyo Hishida, Nobuhiro Ueda, Kenjiro Okamoto, Sakiko Soutome, Yuya Denda, Masaaki Miyakoshi, Kiriko Matsuzawa, Eiji Kondo, Yoshimasa Kitagawa, Daichi Chikazu, Yoshihide Ota, Yasuyuki Shibuya, Masaya Akashi, Tatsushi Matsumura, Masahiro Umeda, Tadaaki Kirita, Makoto Noguchi, Hiroshi Kurita

  Nov. 2022, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 34(6) (6), 734 - 739

  Scientific journal


• The Impact of Pretreatment Low Body Mass Index on Cause-Specific Mortality in Patients with Squamous Cell Carcinoma of the Oral Cavity.

  Kyoko Kurioka, Shin Rin, Mitsunobu Otsuru, Tomohumi Naruse, Takumi Hasegawa, Nobuhiro Yamakawa, Shin-Ichi Yamada, Eiji Hirai, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Masaya Okura

  The association between the pretreatment body mass index (BMI) and oral squamous cell carcinoma (SCC) outcomes is controversial. We aimed to examine the association between BMI and cause-specific mortality due to cancer of the oral cavity and patterns of failure that correlate with increased mortality. We enrolled 2,023 East Asian patients in this multicenter cohort study. We used the cumulative incidence competing risks method and the Fine-Gray model to analyze factors associated with cause-specific mortality, local recurrence, regional metastasis, and distant metastasis as first events. The median follow-up period was 62 mo. The 5-year cause-specific mortality for patients with underweight was 25.7%, which was significantly higher than that for patients with normal weight (12.7%, P < 0.0001). The multivariate model revealed that underweight was an independent risk factor for cause-specific mortality and regional metastasis (P < 0.05). Moreover, patients with underweight displayed a 51% and 55% increased risk of cause-specific mortality and regional metastasis, respectively, compared with their normal weight counterparts. Local recurrence was not associated with the BMI categories; however, the incidence of distant metastasis inversely decreased with BMI value. In summary, being underweight at diagnosis should be considered a high-risk mortality factor for oral SCC.

  Oct. 2022, Nutrition and cancer, 1 - 12, English, International magazine

  Scientific journal


• A Multicenter Study on the Effect of Margin Distance on Survival and Local Control in Stage 1–2 Squamous Cell Carcinoma of the Tongue

  Mitsunobu Otsuru, Takumi Hasegawa, Nobuhiro Yamakawa, Masaya Okura, Shin-ichi Yamada, Eiji Hirai, Toru Inomata, Hirokazu Saito, Kei-ichiro Miura, Kohei Furukawa, Tomofumi Naruse, Souichi Yanamoto, Masahiro Umeda

  Springer Science and Business Media LLC, Sep. 2022, Annals of Surgical Oncology

  Scientific journal


• Prevalence of and risk factors for postoperative complications after lower third molar extraction: A multicenter prospective observational study in Japan.

  Shin-Ichi Yamada, Takumi Hasegawa, Nobuhiko Yoshimura, Yusuke Hakoyama, Tetsuya Nitta, Narihiro Hirahara, Hironori Miyamoto, Hitoshi Yoshimura, Nobuhiro Ueda, Yoshiko Yamamura, Hideki Okuyama, Atsushi Takizawa, Yoshitaka Nakanishi, Eiji Iwata, Daisuke Akita, Ryuichi Itoh, Kiriko Kubo, Seiji Kondo, Hironobu Hata, Yoshito Koyama, Youji Miyamoto, Hirokazu Nakahara, Masaya Akashi, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

  Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient's background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040-1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333-3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050-2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079-6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574-4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction.

  Aug. 2022, Medicine, 101(32) (32), e29989, English, International magazine

  Scientific journal


• Oral melanoma: a multicenter study of 69 patients from Japan.

  Shin-Ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Masashi Tamura, Atsushi Takizawa, Yasumasa Kakei, Masaya Okura, Tomofumi Naruse, Mitsunobu Otsuru, Shin Rin, Michihiro Ueda, Tetsuro Yamashita, Tadaaki Kirita, Yoshihide Ota, Hiroshi Kurita

  OBJECTIVES: The purpose of this multicenter retrospective study was to investigate the demographic characteristics and treatment outcomes of patients with mucosal malignant melanoma (MM) of the oral cavity. MATERIALS AND METHODS: This was a multicenter study involving 8 Japanese universities. The medical records of 69 patients who were diagnosed with primary oral MM between January 2000 and December 2020 were retrospectively analyzed. Overall survival (OS) and prognostic factors for OS were analyzed statistically. RESULTS: There were 40 (58.0%) males and 29 (42.0%) females, and their mean (range) age was 69.8 ± 14.6 (22-96) years old. The most common primary site was the palate (30 patients, 43.5%). Stage IVA was the most common disease stage (36 patients, 52.2%). Radical therapy was performed in 55 patients (79.7%). The 2-year and 5-year OS rates of the 69 patients were 64.6% and 42.5%, respectively. The 2-year and 5-year OS rates of the stage III patients were 85.9% and 72.5%, respectively, and those of the stage IVA patients were 56.3% and 26.0%, respectively. The 1-year OS rate of the stage IVB/IVC patients was 26.7%. The 2-year and 5-year OS rates of the radical therapy group were 74.1% and 50.5%, respectively, whereas the 2-year OS rate of the non-radical therapy group was 26.0%. An advanced T classification was the only identified prognostic factor for OS (hazard ratio: 6.312, 95% confidence interval: 1.133-38.522, p < 0.05). CONCLUSIONS: Early detection and radical treatment are essential for improving the prognosis of oral MM patients. CLINICAL RELEVANCE: Early detection and adequate radical therapy leads to the better prognosis of oral MM patients.

  Aug. 2022, Clinical oral investigations, 26(10) (10), 6187 - 6193, English, International magazine

  Scientific journal


• Treatment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis.

  Yuki Sakamoto, Mitsunobu Otsuru, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Masaya Okura, Nobuhiro Yamakawa, Tadaaki Kirita, Souichi Yanamoto, Masahiro Umeda, Yuka Kojima

  The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS (p = 0.011) and DSS (p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions.

  Jul. 2022, International journal of environmental research and public health, 19(15) (15), English, International magazine

  Scientific journal


• Exploratory clinical trial to evaluate the efficacy and safety of carbon dioxide paste in healthy people.

  Nanae Yatagai, Takumi Hasegawa, Katsusuke Kyotani, Tomohiro Noda, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.

  Jul. 2022, Medicine, 101(29) (29), e29511, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 放射線性顎骨壊死患者を対象とした予後とリスク因子に関する後ろ向き観察研究

  田所 慶誠, 長谷川 巧実, 佐藤 匠, 平岡 佑二郎, 有本 智美, 武田 大介, 楠元 順哉, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 137 - 137, Japanese


• 緩和照射に関する臨床的検討

  松添 雄大, 南川 勉, 瓜生 開人, 棚倉 万紀子, 筧 康正, 長谷川 巧実, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 91 - 91, Japanese


• 局所的炭酸ガス投与による口腔扁平上皮癌の腫瘍免疫抑制に対する改善効果

  八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 榊原 晶子, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2022, 日本口腔科学会雑誌, 71(2) (2), 110 - 110, Japanese


• Effect of compression on mandibular fracture haematoma-derived cells.

  Satomi Arimoto, Takumi Hasegawa, Eiji Iwata, Daisuke Takeda, Masaya Akashi

  Mechanical stress induces a variety of biochemical and morphological reactions in bone cell biology. This study aimed to investigate appropriate pressures of osteogenesis on the biological responses of 3-dimensional cultured human mandibular fracture haematoma-derived cells by compressive loading. Six patients with mandibular fractures who underwent open reduction and internal fixation were included in the study. During the operation, fracture haematomas that formed fibrin clots were manually removed before irrigation. First, pressures were applied to human mandibular fracture haematoma-derived cell-seeded collagen sponges. The sponges were subjected to mechanical compression using loading equipment applied at no compression, 0.5, or 1 mm. Compressive loading was applied to the samples prior to compression for 0, 6, 12, or 24 hours. Collagen sponge samples were collected for quantification of mRNA using several parameters including alkaline phosphatase (ALP), osteopontin (OPN), osterix (OSX), runt-related gene 2 (RUNX2), protein level, and immunocytochemistry (anti-sclerostin). Among these the 0.5 mm compression group compared with the control and 1.0 mm compression groups upregulated mRNA expression of OPN and OSX after 24 hours. Additionally, compared with the control group, a significantly higher OSX gene expression was observed in both the 0.5 mm and 1.0 mm groups after 6, 12, and 24 hours of compression (p < 0.05). However, no significant differences were observed regarding ALP and RUNX2 expression. These results indicated increased stimulation of osteogenesis of the mandibular fracture-line gap in the 0.5 mm compression group compared with the control and 1.0 mm compression groups.

  Jun. 2022, The British journal of oral & maxillofacial surgery, 60(9) (9), 1216 - 1223, English, International magazine

  Scientific journal


• Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  Jun. 2022, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(11) (11), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer.

  Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu

  OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.

  Jun. 2022, Auris, nasus, larynx, 49(3) (3), 477 - 483, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors Associated with Treatment Outcomes and Pathological Features in Patients with Osteoradionecrosis: A Retrospective Study.

  Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi

  A standard treatment for osteoradionecrosis (ORN) has not yet been established because of the diversity. Therefore, identifying the risk factors for a poor prognosis is essential. This study retrospectively investigated the factors associated with the prognosis of ORN in 68 patients. Relevant clinical data of all patients were obtained. Of the patients, 16 who underwent extensive surgery underwent histopathological analysis. The necrotic changes of the anterior and posterior margins in the cortical and cancellous bones were investigated. Multivariate analyses showed statistically significant associations between poor prognosis in patients with ORN and high radiation dose (hazard ratio [HR] 1.15), orocutaneous fistula (HR 2.93), and absence of sequestration (HR 2.49). Histopathological analysis showed a viable anterior margin of the middle portion of the cortical bone for all recovered cases; in contrast, most cases (75%) with a poor prognosis showed necrotic changes. The anterior margin of the cancellous bone was viable and resilient to high irradiation, regardless of the prognosis. These results suggest that patients with orocutaneous fistula should receive early surgical intervention, even if the affected area is limited or asymptomatic. In extensive surgery, a sufficient safety margin of necrotic bone, particularly in the anterior region, is required to improve the prognosis.

  May 2022, International journal of environmental research and public health, 19(11) (11), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Efficacy of Ibuprofen Gargle for Postoperative Pain After Mandibular Third Molar Extraction: Protocol for a Phase II, Placebo-Controlled, Double-Blind, Randomized Crossover Trial.

  Yasumasa Kakei, Takeshi Ioroi, Takahiro Ito, Yutaro Okazaki, Takumi Hasegawa, Ikuko Yano, Masaya Akashi

  BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.

  May 2022, JMIR research protocols, 11(5) (5), e35533, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 多施設後ろ向き試験による舌癌における手術断端近接症例の検討 JOOG study(RA2101)

  大鶴 光信, 長谷川 巧実, 山川 延宏, 大倉 正也, 山田 慎一, 平井 英治, 猪俣 徹, 齋藤 寛一, 三浦 桂一郎, 古川 浩平, 鳴瀬 智史, 柳本 惣市, 梅田 正博

  (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 216 - 216, Japanese


• Perioperative oral care can prevent surgical site infection after colorectal cancer surgery: A multicenter, retrospective study of 1,926 cases analyzed by propensity score matching.

  Hiroshi Nobuhara, Yasuhiro Matsugu, Sakiko Soutome, Saki Hayashida, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Hirokazu Nakahara, Miyuka Nakahara, Nobuhiro Ueda, Tadaaki Kirita, Tomohisa Nakamura, Yasuyuki Shibuya, Kazuyo Mori, Taihei Yamaguchi

  BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.

  Apr. 2022, Surgery, 172(2) (2), 530 - 536, English, International magazine

  Scientific journal


• Risk factors for osteoradionecrosis of the jaw in patients with oral or oropharyngeal cancer: Verification of the effect of tooth extraction before radiotherapy using propensity score matching analysis

  Yuka Kojima, Mitsunobu Otsuru, Takumi Hasegawa, Nobuhiro Ueda, Tadaaki Kirita, Shin ichi Yamada, Hiroshi Kurita, Yasuyuki Shibuya, Madoka Funahara, Masahiro Umeda

  Apr. 2022, Journal of Dental Sciences, 17(2) (2), 1024 - 1029

  Scientific journal


• Success of dental implants in patients with large bone defect and analysis of risk factors for implant failure: a non-randomized retrospective cohort study.

  Takumi Hasegawa, Aki Sasaki, Izumi Saito, Satomi Arimoto, Nanae Yatagai, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.

  Mar. 2022, Clinical oral investigations, 26(3) (3), 2743 - 2750, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors associated with post-extraction bleeding in patients on warfarin or direct-acting oral anticoagulants: a retrospective cohort study.

  Eiji Iwata, Akira Tachibana, Junya Kusumoto, Takumi Hasegawa, Ryo Kadoya, Yui Enomoto, Naoki Takata, Masaya Akashi

  PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.

  Jan. 2022, Oral and maxillofacial surgery, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preventive effects of betamethasone valerate ointment for radiation-induced severe oral mucositis in patients with oral or oropharyngeal cancer: protocol for a multicentre, phase II, randomised controlled trial (Bet-ROM study).

  Sakiko Soutome, Mitsunobu Otsuru, Maho Murata, Yumiko Kawashita, Masako Yoshimatsu, Madoka Funahara, Yoshiko Yamamura, Takumi Hasegawa, Shin-Ichi Yamada, Yuka Kojima, Hirokazu Nakahara, Yasuyuki Shibuya, Masahiro Umeda, Toshiyuki Saito

  INTRODUCTION: This is a randomised, multi-centre, open-label, phase II study to evaluate the efficacy of betamethasone valerate ointment on radiation-induced oral mucositis in patients with head and neck cancer undergoing concomitant radiotherapy with cisplatin or cetuximab. METHODS AND ANALYSIS: The trial will take place at seven hospitals in Japan. Patients will be randomised (1:1) into betamethasone and control groups after the occurrence of grade 1 oral mucositis. In the betamethasone group, patients will use betamethasone valerate ointment five times a day, in addition to usual oral hygiene guidance. The primary endpoint is the incidence and onset time of grade 3 oral mucositis. The secondary endpoints are the incidence and onset time of grade 2 oral mucositis, incidence and onset time of oral candidiasis, completion of radiation therapy and adverse events. Target accrual is 102 patients with a two-sided type I error rate of 5% and 80% power to detect an 80% risk reduction in the incidence of grade 3 oral mucositis. ETHICS AND DISSEMINATION: This study was approved by the Clinical Research Review Board of Nagasaki University (No. CRB20-009). All participants will be required to provide written informed consent. Findings will be disseminated through scientific and professional conferences and peer-reviewed journal publication. The datasets generated during the study will be available from the corresponding author on reasonable request. TRIAL REGISTRATION NUMBER: jRCTs071200013.

  Jan. 2022, BMJ open, 12(1) (1), e056781, English, International magazine

  Scientific journal


• アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

  (一社)日本口腔腫瘍学会, Dec. 2021, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, Japanese


• アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也

  (一社)日本口腔腫瘍学会, Dec. 2021, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, Japanese


• 口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例

  重永 一輝, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, Japanese


• 放射線下顎骨壊死に対する腓骨皮弁再建後にインプラントによる咬合回復を行った1例

  武田 大介, 有本 智美, 長谷川 巧実, 明石 昌也

  (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 227 - 227, Japanese


• Local Application of Transcutaneous Carbon Dioxide Paste Decreases Inflammation and Accelerates Wound Healing.

  Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi

  INTRODUCTION:  Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.

  Nov. 2021, Cureus, 13(11) (11), e19518, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for severe radiation-induced oral mucositis in patients with oral cancer

  Sakiko Soutome, Souichi Yanamoto, Mika Nishii, Yuka Kojima, Takumi Hasegawa, Madoka Funahara, Masaya Akashi, Toshiyuki Saito, Masahiro Umeda

  Oct. 2021, Journal of Dental Sciences, 16(4) (4), 1241 - 1246

  Scientific journal


• Peripheral facial nerve schwannoma at the inferior mandibular margin: a case report.

  Akiko Sakakibara, Takumi Hasegawa, Daisuke Takeda, Junya Kusumoto, Shunsuke Sakakibara, Masaya Akashi

  Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.

  Jul. 2021, Journal of surgical case reports, 2021(7) (7), rjab299, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma.

  Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi

  Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein-Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.

  Jun. 2021, Diagnostics (Basel, Switzerland), 11(6) (6), English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Case Report of Tongue Lymphoepithelial Carcinoma with a Histological Diagnostic Dilemma

  Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi

  Jun. 2021, DIAGNOSTICS, 11(6) (6), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study.

  T Hasegawa, N Ueda, S I Yamada, S Kato, E Iwata, S Hayashida, Y Kojima, M Shinohara, I Tojo, H Nakahara, T Yamaguchi, T Kirita, H Kurita, Y Shibuya, S Soutome, M Akashi

  Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.

  May 2021, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子

  西井 美佳, 五月女 さき子, 岩田 英治, 長谷川 巧実, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也

  (一社)日本口腔ケア学会, Apr. 2021, 日本口腔ケア学会雑誌, 15(3) (3), 145 - 145, Japanese


• Occurrence and Treatment Outcome of Late Complications After Free Fibula Flap Reconstruction for Mandibular Osteoradionecrosis.

  Junya Yamashita, Masaya Akashi, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Kazunobu Hashikawa

  PURPOSE: This study aimed to evaluate the occurrence and treatment outcome of late complications after free fibula osteocutaneous flap reconstruction for mandibular osteoradionecrosis (ORN). METHODS: We enrolled 15 consecutive patients (14 men, one woman; median age 65 years, range 57-80 years) who underwent free fibula reconstruction for advanced mandibular ORN during 2013-2017 with two or more years of follow-up. Late complications included infection, plate exposure, and recurrence at the resection margin. The effect of perioperative antibiotic administration on late complications was also assessed. RESULTS: Late complications occurred in 33.3% (5/15) of patients, including two infections (local and distant), two plate exposures, and two recurrences (plate exposure and recurrence occurred in one patient). Perioperative antibiotic administration duration did not significantly affect the occurrence of postoperative late complications. All late complications were treated without problems. CONCLUSIONS: Late complications after ORN reconstructive surgery are not uncommon, but can be treated properly.

  Mar. 2021, Cureus, 13(3) (3), e13833, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Occurrence and Treatment Outcome of Late Complications After Free Fibula Flap Reconstruction for Mandibular Osteoradionecrosis

  Junya Yamashita, Masaya Akashi, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Kazunobu Hashikawa

  Mar. 2021, CUREUS JOURNAL OF MEDICAL SCIENCE, 13(3) (3), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Can CT predict the development of oroantral fistula in patients undergoing maxillary third molar removal?

  Eiji Iwata, Takumi Hasegawa, Masaki Kobayashi, Akira Tachibana, Naoki Takata, Toshiya Oko, Daisuke Takeda, Yoshiki Ishida, Tsuyoshi Fujita, Ikuko Goto, Junichiro Takeuchi, Masaya Akashi

  PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.

  Mar. 2021, Oral and maxillofacial surgery, 25(1) (1), 7 - 17, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association between dental extraction after radiotherapy and osteoradionecrosis: A multi-centre retrospective study.

  Izumi Saito, Takumi Hasegawa, Yumiko Kawashita, Shinichiro Kato, Shin-Ichi Yamada, Yuka Kojima, Nobuhiro Ueda, Masahiro Umeda, Yasuyuki Shibuya, Hiroshi Kurita, Tadaaki Kirita, Masaya Akashi

  OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.

  Mar. 2021, Oral diseases, 28(4) (4), 1181 - 1187, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Time to Recurrence Associated With Poor Prognosis in Japanese Oral Squamous Cell Carcinoma Patients

  Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  Feb. 2021, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The prospective evaluation and risk factors of dysphagia after surgery in patients with oral cancer.

  Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi

  BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.

  Jan. 2021, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma.

  Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki

  BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.

  Jan. 2021, Radiation oncology (London, England), 16(1) (1), 1 - 1, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bacterial Colonization of the Condyle in Patients with Advanced Mandibular Osteoradionecrosis: Analysis of Hemimandibulectomy Specimens.

  Daisuke Takeda, Kazunobu Hashikawa, Manabu Shigeoka, Maki Kanzawa, Nanae Yatagai, Satomi Arimoto, Junya Kusumoto, Takumi Hasegawa, Hiroto Terashi, Masaya Akashi

  Advanced mandibular osteoradionecrosis (ORN) sometimes requires extended resection (e.g., hemimandibulectomy). Bacterial infection contributes to ORN pathogenesis. To control infection and determine the extent of debridement required, an understanding of bacterial spread within sites of mandibular ORN is important. The current study used a histopathological approach to assess bacterial colonization in the mandibular condyle and elucidate possible paths of bacterial spread towards the mandibular condyle. Four hemimandibulectomy specimens were selected. Areas of bone destruction were macroscopically assessed and confirmed using hematoxylin and eosin staining. Bacterial presence within mandibular condyle was confirmed with Gram staining. Bone exposure was observed in the molar area in all specimens. Macroscopic bone destruction was apparent especially near the medial side of the cortical wall. Gram staining revealed bacterial colonization of the mandibular condyle in three of the four specimens. In conclusion, bacteria tended to spread posteriorly and through the medial side of the mandibular cortical wall. In patients with advanced ORN, the potential for bacterial colonization of the mandibular condyle should be considered during treatment.

  2021, International journal of dentistry, 2021, 9998397 - 9998397, English, International magazine

  Scientific journal


• Transcutaneous Carbon Dioxide Decreases Immunosuppressive Factors in Squamous Cell Carcinoma In Vivo.

  Nanae Yatagai, Takumi Hasegawa, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi

  INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.

  2021, BioMed research international, 2021, 5568428 - 5568428, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effects of a miconazole oral patch on preventing development of oral candidiasis in patients with head and neck cancer undergoing radiotherapy: results of a preliminary study quantifying the prevalence of Candida albicans in saliva

  Ryuichiro Funahara, Sakiko Soutome, Madoka Funahara, Shoma Tsuda, Takumi Hasegawa, Masahiro Umeda, Masaya Akashi

  2021, Supportive Care in Cancer

  Scientific journal


• Can four-dimensional computed tomography support diagnosis and treatment planning?: a case report before and after coronoidectomy.

  Wensu Huang, Masaya Akashi, Takuro Nishio, Noriyuki Negi, Akira Kimoto, Takumi Hasegawa

  INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.

  Dec. 2020, Oral and maxillofacial surgery, 24(4) (4), 515 - 520, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Does prophylactic antibiotic administration for tooth extraction affect PT-INR in patients taking warfarin?

  Eiji Iwata, Akira Tachibana, Junya Kusumoto, Naoki Takata, Takumi Hasegawa, Masaya Akashi

  BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.

  Nov. 2020, BMC oral health, 20(1) (1), 331 - 331, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 消化器外科SSI対策 経験からその検証へ 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本外科感染症学会, Oct. 2020, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, Japanese


• 消化器外科SSI対策 経験からその検証へ 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本外科感染症学会, Oct. 2020, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, Japanese


• 顎骨骨髄炎発症範囲推定のための頭部CT・切除顎骨CTの位置合わせ自動化

  松岡 志宜, 盛田 健人, 武田 大介, 長谷川 巧実, 若林 哲史

  (一社)日本医用画像工学会, Sep. 2020, 日本医用画像工学会大会予稿集, 39回, 30 - 30, Japanese


• 顎骨骨髄炎発症範囲推定のための頭部CT・切除顎骨CTの位置合わせ自動化

  松岡 志宜, 盛田 健人, 武田 大介, 長谷川 巧実, 若林 哲史

  (一社)日本医用画像工学会, Sep. 2020, 日本医用画像工学会大会予稿集, 39回, 173 - 177, Japanese


• 膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果

  山口 泰平, 高島 裕之, 森田 麻希, 渋谷 恭之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 兒島 由佳, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 森 和代, 於保 孝彦

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 114 - 114, Japanese


• 周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討

  高島 裕之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 上田 順宏, 下辻 寛子, 桐田 忠昭, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 山口 泰平, 森 和代, 渋谷 恭之

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 123 - 123, Japanese


• 口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景

  筧 康正, 長谷川 巧実, 明石 昌也

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 53 - 54, Japanese


• 大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究

  延原 浩, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 小西 尚晃, 中原 寛和, 上田 順宏, 下辻 寛子, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代

  (一社)日本口腔ケア学会, Sep. 2020, 日本口腔ケア学会雑誌, 14(3) (3), 122 - 122, Japanese


• Clinical investigation on sarcoma in oral and maxillofacial regions: A multicenter retrospective analysis in Japan

  Ryuichi Itoh, Shin ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita

  Sep. 2020, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32(5) (5), 356 - 359

  Scientific journal


• 口腔癌cN(+)における根治的頸部郭清範囲の検討

  手島 直則, 窪田 雄一, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 大月 直樹, 武田 大介, 筧 康正, 長谷川 巧実

  (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 183 - 183, Japanese


• 顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討

  下間 祐輝, 武田 大介, 佐々木 亜紀, 小林 英里奈, 八橋 明子, 齋藤 泉, 楠元 順哉, 長谷川 巧実, 古土井 春吾, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 121 - 121, Japanese


• 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討

  廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也

  (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, Japanese


• Prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction on warfarin therapy: a multicenter retrospective study in Japan.

  Shin-Ichi Yamada, Takumi Hasegawa, Sakiko Soutome, Hitoshi Yoshimura, Masaaki Miyakoshi, Nobuhiro Ueda, Kenjiro Okamoto, Sumiyo Hishida, Satoshi Rokutanda, Hirokazu Nakahara, Shigeyuki Fujita, Masaya Akashi, Yoshimasa Kitagawa, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

  Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.

  Jul. 2020, Odontology, 108(3) (3), 462 - 469, English, Domestic magazine

  [Refereed]

  Scientific journal


• Neutrophil-lymphocyte ratio associated with poor prognosis in oral cancer: a retrospective study.

  Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi

  BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.

  Jun. 2020, BMC cancer, 20(1) (1), 568 - 568, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical significance of the G8 screening tool in elderly patients with oral squamous cell carcinoma.

  Shin-Ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita

  OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.

  Jun. 2020, Clinical oral investigations, 24(6) (6), 1953 - 1961, English, International magazine

  [Refereed]

  Scientific journal


• Effects of preoperative dental examination and oral hygiene instruction on surgical site infection after hepatectomy: a retrospective study.

  Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi

  PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.

  May 2020, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas: a retrospective multicenter study of 326 patients.

  Nishii M, Soutome S, Kawakita A, Yutori H, Iwata E, Akashi M, Hasegawa T, Kojima Y, Funahara M, Umeda M, Komori T.

  May 2020, Support Care Cancer., 283(3) (3), 1069 - 1075

  [Refereed]


• Extent of neck dissection for patients with clinical N1 oral cancer.

  Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi

  BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.

  Mar. 2020, International journal of clinical oncology, 25(6) (6), 1067 - 1071, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A multicenter retrospective investigation on the efficacy of perioperative oral management in cancer patients.

  Shin-Ichi Yamada, Sakiko Soutome, Takumi Hasegawa, Itaru Tojyo, Hirokazu Nakahara, Mao Kawakami, Marina Hirose, Shigeyuki Fujita, Takahide Komori, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita

  Patients develop a number of oral complications during cancer treatments. Oral bacteria are associated with the onset of dental focal infections and the progression of oral mucositis. Dental focal infections are frequently associated with the systemic onset of bacteremia, sepsis, and pneumonia. The degeneration of oral function with these complications may become an obstacle to cancer treatments. Although comprehensive oral management, including oral care, the removal of dental focal infections, and improvements in oral function with dentures, is conducted for cancer patients in Japan, few studies have assessed its efficacy.The aim of the present study was to investigate the incidence of dental/oral complications in cancer patients with perioperative oral managements (POMs) based on a large number of case series with a multicenter retrospective analysis.The medical records of cancer patients with POMs were retrospectively reviewed and the incidence of oral complications and efficacy of oral management were investigated.A total of 2744 cancer patients with POMs (1684 males and 1080 females, mean age 65.9 ± 13.0 years) were included and investigated in the present study. Among these patients, 2097 (76.4%) started POM before the initiation of cancer treatments, with 2130 (77.6%) receiving oral care only and 391 (14.2%) being subjected to invasive treatments, such as tooth extraction. The incidence of dental focal infections during the period of cancer treatments was 8.2%. The most frequent infection was acute periodontitis, including alveolar abscesses (112 patients, 4.1%). The incidence of grade 2 and 3 oral mucositis was 2.8%. Prolonged fever was observed in 113 patients (4.1%), with 7 having dental focal infections (6.2%). These incidence rates were lower than those reported previously.Based on analyses of a large number of patients, the present results support the efficacy of oral management in cancer patients. However, further studies are needed to establish adequate oral management guidelines for cancer patients.

  Mar. 2020, Medicine, 99(10) (10), e19129, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy.

  Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, Yoshihiro Kakeji

  BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.

  Mar. 2020, Annals of surgical oncology, 27(3) (3), 683 - 690, English, International magazine

  [Refereed]


• Prevention of postoperative pneumonia by perioperative oral care in patients with esophageal cancer undergoing surgery: a multicenter retrospective study of 775 patients.

  Sakiko Soutome, Takumi Hasegawa, Taihei Yamguchi, Kumiko Aoki, Naritomo Kanamura, Takao Mukai, Junichi Yamazoe, Masaya Nishikawa, Emiko Isomura, Kazuto Hoshi, Masahiro Umeda

  PURPOSE: Postoperative pneumonia is one of the major complications after esophageal cancer surgery. The risk factors associated with postoperative pneumonia are poor general health, smoking, decreased pulmonary function, diabetes mellitus, surgical stress, old age, postoperative aspiration, and oral hygiene. In this study, we examined the effect of perioperative oral care on reducing postoperative pneumonia since the evidence to-date is not clear. METHODS: A multicenter, retrospective investigation of the relationship between perioperative oral care and incidence of postoperative pneumonia in patients undergoing esophageal cancer surgery was conducted. A total of 775 patients who underwent thoracoscopic esophageal resection at 25 hospitals between 2016 and 2017 were enrolled in the study. Various factors were examined for correlation with development of postoperative pneumonia. RESULTS: Multivariate analysis showed that old age, smoking habit, lower hemoglobin, higher creatinine, postoperative dysphagia, and lack of oral care intervention were independent risk factors for pneumonia. Oral care was more effective in preventing pneumonia in hospitals in which the incidence of postoperative pneumonia was lower than 20%, while it was not effective in hospitals in which the incidence was higher than 20%. CONCLUSION: Results of the study suggest that it is recommended to carry out perioperative oral care in esophageal cancer surgery.

  Jan. 2020, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28(9) (9), 4155 - 4162, English, International magazine

  [Refereed]

  Scientific journal


• A case of papillary squamous cell carcinoma of the mandibular gingiva

  ARIMOTO Satomi, HASEGAWA Takumi, MATSUMOTO Kousuke, SHIGEOKA Manabu, MINAMIKAWA Tsutomu, KOMORI Takahide

  Papillary squamous cell carcinoma (PSCC) is a rare variant of squamous cell carcinoma with only a few documented cases in the oral cavity. We report the case of a 70-year-old man who presented with papillary squamous cell carcinoma of the mandibular gingiva.

  The patient was referred to our department because of a papillary tumor in the right mandibular gingiva. A physical examination revealed an exophytic papillary tumor in the right mandibular gingiva. Biopsy samples for histopathological diagnosis were taken two times. However, the biopsies did not reveal squamous cell carcinoma. Moreover, the pathological diagnosis obtained from intraoperative frozen-section analysis was cancer negative. Therefore, the operation consisted of resection of the tumor including a margin of 5-7 mm. Microscopically, the tumor showed exophytic papillary proliferation with fibrovascular cores and consisted of atypical squamous epithelial cells. The pathological diagnosis was PSCC. Three months later, local recurrence was observed and was resected again. The patient was healthy and remained free from tumors 18 months after the second operation. We report a rare case of PSCC. With small biopsy specimens, the diagnosis of PSCC was challenging.

  Japanese Society of Oral and Maxillofacial Surgeons, 2020, Japanese Journal of Oral and Maxillofacial Surgery, 66(5) (5), 219 - 223, Japanese


• Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells.

  Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi

  Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.

  2020, BioMed research international, 2020, 1281645 - 1281645, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Drug holiday clinical relevance verification for antiresorptive agents in medication-related osteonecrosis cases of the jaw.

  Saki Hayashida, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Eiji Kondo, Hiroshi Kurita, Masahiro Umeda

  Treatment strategies of medication-related osteonecrosis of the jaw (MRONJ) are controversial. Recently, surgical treatment has been reported as superior to nonsurgical treatment, but the contribution discontinued antiresorptive agent use during MRONJ treatment remains unclear. This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017 were included in this multicenter retrospective study. Multivariate Cox regression analysis showed that the primary disease (osteoporosis or malignant tumor), diabetes, serum albumin, and treatment method (surgical or nonsurgical) were significantly correlated with the cure rate. The cumulative 1-year cure rates in the surgical and nonsurgical treatment groups were 64.7% and 18.2%, respectively. However, discontinuing antiresorptive agents did not influence the treatment outcome in the cohort overall, or in 230 patients after performing propensity score matching among the discontinuation and continuation groups. When stratifying by treatment method, antiresorptive agent discontinuation significantly increased the cure rate in patients with osteoporosis who underwent nonsurgical treatment. In patients with malignant tumors undergoing nonsurgical therapy, discontinuing the antiresorptive agent was associated with a better treatment outcome, but not with statistical significance. In contrast, drug holidays showed no effect on improving outcomes in patients with both osteoporosis and malignant tumors who underwent surgical therapy. Thus, regardless of the primary disease, discontinuing antiresorptive agents during treatment for MRONJ may not be necessary and may be helpful in some cases. Future prospective trials should examine this question further.

  Jan. 2020, Journal of bone and mineral metabolism, 38(1) (1), 126 - 134, English, Domestic magazine

  [Refereed]

  Scientific journal


• 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

  高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

  (一社)日本有病者歯科医療学会, Dec. 2019, 有病者歯科医療, 28(6) (6), 471 - 471, Japanese


• Prevention of postoperative pneumonia by perioperative oral care

  Sakiko Soutome, Takumi Hasegawa, Taihei Yamaguchi, Kumiko Aoki

  Dec. 2019

  [Refereed]


• Effect of low-intensity pulsed ultrasound after intraoral vertical ramus osteotomy.

  Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Chizu Tateishi, Masaya Akashi, Shungo Furudoi, Takahide Komori

  OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.

  Corresponding, Dec. 2019, Oral surgery, oral medicine, oral pathology and oral radiology, 128(6) (6), 581 - 589, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative adjuvant therapy for patients with locoregionally advanced oral squamous cell carcinoma who are at high risk of recurrence.

  Yanamoto S, Denda Y, Ota Y, Hasegawa T, Akashi M, Okura M, Yamada S, Kurita H, Yamakawa N, Kirita T, Ueda M, Umeda M, the Japan Oral, Oncology, Group

  Nov. 2019, International Journal of Oral & Maxillofacial Surgery, in press

  [Refereed]


• [総説]口腔・中咽頭がん患者の放射線性顎骨壊死発症リスク因子について：多施設共同後ろ向き研究の結果より

  兒島由桂, 河岡有美, 川下由美子, 山田慎一, 栗田 浩, 長谷川巧実, 古森孝英, 明石昌也, 上田順宏, 桐田忠昭, 高島裕之, 渋谷恭之, 梅田正博

  Sep. 2019, 日本口腔腫瘍学会誌, 31(3) (3), 117-120


• Dental intervention against osteoradionecrosis of the jaws in irradiated patients with head and neck malignancy: a single-arm prospective study.

  Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori

  BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.

  Sep. 2019, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of size difference between hemiglossectomy and reconstruction flap on oral functions: A retrospective cohort study.

  Sakakibara A, Kusumoto J, Sakakibara S, Hasegawa T, Akashi M, Minamikawa T, Furudoi S, Hashikawa K, Komori T.

  BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.

  Jul. 2019, J Plast Reconstr Aesthet Surg, 72(7) (7), 1135 - 1141, English, International magazine

  [Refereed]

  Scientific journal


• Multicenter retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with level IV/V metastasis.

  Hasegawa T, Yanamoto S, Otsuru M, Kakei Y, Okura M, Yamakawa N, Yamada SI, Ota Y, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Japan Oral Oncology Group (JOOG).

  BACKGROUND: The purpose of this study was to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma and level IV/V metastasis and to compare patients who underwent no postoperative therapy with those who underwent postoperative radiotherapy (RT) and concomitant chemoradiotherapy (CCRT). METHODS: We evaluated 669 patients. Clinicopathological data, postoperative therapy, and clinical course were investigated. RESULTS: Sixty-one patients (9.1%) developed level IV/V metastasis. The 3-year cumulative overall survival rates of patients with and without level IV/V metastasis were 47.3% and 64.3%, respectively. Tongue tumors, pN2 or N3 classification, and moderate or poor differentiation were significantly associated with the development of level IV/V metastasis. The surgery+RT/CCRT group was associated with better 3-year cumulative disease-specific survival and overall survival rates than the surgery only group. CONCLUSION: Adjuvant therapy (RT alone or CCRT) after surgery is recommended for patients with level IV/V metastasis.

  Lead, Jul. 2019, Head Neck., 41(7) (7), 2256 - 2263, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A radiologic evaluation of the incidence and morphology of maxillary sinus septa in Japanese dentate maxillae.

  Daisuke Takeda, Takumi Hasegawa, Izumi Saito, Satomi Arimoto, Masaya Akashi, Takahide Komori

  PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.

  Jun. 2019, Oral and maxillofacial surgery, 23(2) (2), 233 - 237, English, International magazine

  [Refereed]

  Scientific journal


• Effects of perioperative oral care on prevention of postoperative pneumonia after lung resection: Multicenter retrospective study with propensity score matching analysis.

  Iwata E, Hasegawa T, Yamada SI, Kawashita Y, Yoshimatsu M, Mizutani T, Nakahara H, Mori K, Shibuya Y, Kurita H, Komori T.

  BACKGROUND: Postoperative pneumonia can be a fatal complication that may occur after lung resection in cancer patients. Some reports have shown that the incidence of postoperative pneumonia is decreased after esophageal surgery by perioperative oral care; however, there exist no data to suggest that a lack of perioperative oral care can be a risk factor for postoperative pneumonia after lung resection. To investigate the association between the preventive effect of oral care and postoperative pneumonia, we conducted a multicenter, retrospective study of lung cancer patients who underwent lung resection. METHODS: Between January 2014 and December 2016, a total of 721 patients underwent lung resections at 1 of the 6 hospitals included in our study. Among 721 patients, 280 (38.8%) received perioperative oral care, and the remaining 441 (61.2%) did not receive any such care. Propensity score matching was performed to minimize selection biases associated with the comparison of retrospective data between the oral care and control groups. RESULTS: Of the 721 patients, 54 (7.5%) experienced postoperative pneumonia involving 13 of the 280 patients (4.6%) in the oral care group and 41 of the 441 patients (9.3%) in the control group (P = .02). On propensity score analysis, a significant difference was also found between oral care intervention and incidence of postoperative pneumonia (P = .002). CONCLUSION: Our results suggest that perioperative oral care is an effective method to decrease the occurrence of postoperative pneumonia in patients who have undergone lung resection.

  Corresponding, May 2019, Surgery, 165(5) (5), 1003 - 1007, English, International magazine

  [Refereed]

  Scientific journal


• Clinical Evaluation of CO2 Laser Vaporization Therapy for Oral Lichen Planus: A Single-Arm Intervention Study.

  Matsumoto K, Matsuo K, Yatagai N, Enomoto Y, SHIGEOKA MANABU, Hasegawa T, Suzuki H, Komori T

  May 2019, Photobiomodul Photomed Laser Surg, 37(3) (3), 175 - 81, English

  [Refereed]

  Scientific journal


• 多施設共同研究 高用量骨吸収抑制薬投与患者の抜歯と顎骨壊死発症 本学会共同研究委員会による多施設共同前向き研究の提案 抜歯例について

  長谷川 巧実, 船原 まどか, 梅田 正博, 夏目 長門, 日本口腔ケア学会共同研究委員会ワーキング3

  (一社)日本口腔ケア学会, Apr. 2019, 日本口腔ケア学会雑誌, 13(3) (3), 120 - 120, Japanese


• 多施設共同研究 高用量骨吸収抑制薬投与患者の顎骨壊死発症予防法 本学会共同研究委員会による多施設共同前向き研究の提案 非抜歯例について

  兒島 由佳, 長谷川 巧実, 船原 まどか, 梅田 正博, 夏目 長門, 日本口腔ケア学会共同研究委員会ワーキング3

  (一社)日本口腔ケア学会, Apr. 2019, 日本口腔ケア学会雑誌, 13(3) (3), 122 - 122, Japanese


• Induced Pluripotent Stem Cell-related Genes Correlate With Poor Prognoses of Oral Squamous Cell Carcinoma.

  Yumi Muraki, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Eiji Iwata, Izumi Saito, Rika Amano, Akiko Sakakibara, Masaya Akashi, Takahide Komori

  BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.

  Corresponding, Mar. 2019, Anticancer research, 39(3) (3), 1205 - 1216, English, International magazine

  [Refereed]

  Scientific journal


• Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma

  Yamakawa N, Kirita T, Umeda M, Yanamoto S, Ota Y, Otsuru M, Okura M, Kurita H, Yamada SI, Hasegawa Takumi, Aikawa T, Komori T, Ueda M, Japan Oral, Oncology, Group

  Mar. 2019, J Surg Oncol, 119(3) (3), 370 - 378, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching.

  Mitsunobu Otsuru, Yoshihide Ota, Souichi Yanamoto, Masaya Okura, Masahiro Umeda, Tadaaki Kirita, Hiroshi Kurita, Michihiro Ueda, Takahide Komori, Nobuhiro Yamakawa, Takahiro Kamata, Takumi Hasegawa, Takahiko Shibahara, Youichi Ohiro, Yoshihiro Yamashita, Kazuma Noguchi, Tadahide Noguchi, Kazunari Karakida, Hiroyuki Naito, Tomonao Aikawa, Tetsuro Yamashita, Daijiro Kabata, Ayumi Shintani

  BACKGROUND: This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer. METHODS: Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups. RESULTS: The results showed that the OS rates among the 1234 enrolled patients were 85.5% in the END group and 90.2% in the OBS group (P = 0.182). The DSS rates were 87.0% in the END group and 94.3% in the OBS group (P = 0.003). Among the matched patients, the OS rates were 87.1% in the END group and 76.2% in the OBS group (P = 0.0051), and the respective DSS rates were 89.2% and 82.2% (P = 0.0335). CONCLUSION: This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4-5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.

  Feb. 2019, Annals of surgical oncology, 26(2) (2), 555 - 563, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medication-related osteonecrosis of the jaw after tooth extraction in cancer patients: a multicenter retrospective study

  Hasegawa Takumi, Hayashida S, Kondo E, Takeda Y, Miyamoto H, Kawaoka Y, Ueda N, Iwata E, Nakahara H, Kobayashi M, Soutome S, Yamada SI, Tojyo I, Kojima Y, Umeda M, Fujita S, Kurita H, Shibuya Y, Kirita T, Komori T, Japanese Study, Group of Co-operative Dentistry with Medicine(JCDM

  Jan. 2019, Osteoporos Int, 30(1) (1), 231 - 239, English

  [Refereed]

  Scientific journal


• MRONJ治療時の休薬の意義はあるか?

  林田 咲, 坂本 英之, 長谷川 巧実, 古森 孝英, 兒島 由佳, 河岡 有美, 上田 順宏, 桐田 忠昭, 宮本 大模, 渋谷 恭之, 篠原 光代, 中原 寛和, 近藤 英司, 栗田 浩, 藤田 茂之, 梅田 正博

  (一社)日本有病者歯科医療学会, Dec. 2018, 有病者歯科医療, 27(6) (6), 495 - 495, Japanese


• 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

  長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2018, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, Japanese


• Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma.

  Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Izumi Saito, Rika Amano, Masaya Akashi, Takahide Komori

  BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.

  Nov. 2018, Anticancer research, 38(11) (11), 6157 - 6162, English, International magazine

  [Refereed]

  Scientific journal


• Gold nanoparticles enhance X-ray irradiation-induced apoptosis in head and neck squamous cell carcinoma in vitro

  Teraoka S, Kakei Y, Akashi Masaya, Iwata E, Hasegawa Takumi, Miyawaki Daisuke, Sasaki Ryohei, Komori Takahide

  Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.

  Nov. 2018, Biomed Rep, 9(5) (5), 415 - 420, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of local application of transcutaneous carbon dioxide on survival of random-pattern skin flaps.

  Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori

  INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.

  Nov. 2018, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71(11) (11), 1644 - 1651, English, International magazine

  [Refereed]

  Scientific journal


• 希少がんである口腔癌を多方面から考える 早期舌癌における頸部後発転移に対する新規予測因子の検討

  山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘, 日本口腔がん臨床研究グループ

  (一社)日本癌治療学会, Oct. 2018, 日本癌治療学会学術集会抄録集, 56回, SY12 - 3, English


• 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

  山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 廣瀬 満理奈, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

  (一社)日本癌治療学会, Oct. 2018, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, English

  [Refereed]


• Long-Term Effects on Volume Change in Musculocutaneous Flaps after Head and Neck Reconstruction

  Sakakibara A, Kusumoto J, Sakakibara S, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  OBJECTIVE:  Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS:  We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS:  Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION:  Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.

  Sep. 2018, J Reconstr Microsurg, 35(4) (4), 235 - 243, English, International magazine

  [Refereed]

  Scientific journal


• Ionizing Radiation Enhances Paracellular Permeability Through Alteration of Intercellular Junctions in Cultured Human Lymphatic Endothelial Cells

  Kishimoto M, Akashi Masaya, Kakei Y, Kusumoto J, Sakakibara A, Hasegawa Takumi, Furudoi Shungo, Sasaki Ryohei, Komori Takahide

  BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.

  Aug. 2018, Lymphat Res Biol, 16(4) (4), 390 - 396, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcutaneous carbon dioxide enhances the antitumor effect of radiotherapy on oral squamous cell carcinoma.

  Eiji Iwata, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Izumi Saito, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Ryohei Sasaki, Ryosuke Kuroda, Takahide Komori

  Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia. Considering the previous study, we hypothesized that transcutaneous CO2 may enhance the antitumor effect of RT on OSCC by improving intratumoral hypoxia, thereby overcoming radioresistance. In the present study, the combination of transcutaneous CO2 and RT significantly inhibited tumor growth compared with other treatments. This combination therapy also led to decreased expression of HIF-1α in parallel with increased expression of the cleaved forms of caspase-3-8-9 and PARP, which play essential roles in mitochondrial apoptosis. Additionally, the combination therapy increased the expression of ROS modulator 1 and subsequent mitochondrial ROS production, compared to RT alone. These results indicated that transcutaneous CO2 could potentially improve the antitumor effect of RT by decreasing the intratumoral hypoxia and increasing the mitochondrial apoptosis. Our findings indicated that CO2 therapy may be a novel adjuvant therapy in combination with RT for OSCC.

  Jul. 2018, Oncology reports, 40(1) (1), 434 - 442, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Multi-center retrospective study of the prognosis and treatment outcomes of Japanese oral squamous cell carcinoma patients with single lymph node metastasis and extra nodal extension

  Hasegawa Takumi, Yanamoto S, Otsuru M, Kakei Y, Okura M, Yamakawa N, Yamada SI, Ota Y, Umeda M, Kirita T, Kurita H, Ueda M, Komori T, Japan Oral, Oncology, Group

  BACKGROUND: Oral squamous cell carcinoma (OSCC) containing single lymph node metastasis (pN1) with extra nodal extension (ENE) is a rare clinical situation. Therefore, it is unclear whether pN1 with ENE is at high risk of recurrence among the OSCC population, or whether postoperative radiotherapy (RT)/concomitant chemoradiotherapy (CCRT) is effective in these cases. OBJECTIVES: The purpose of this retrospective study was to investigate the prognosis and compare between no postoperative therapy and postoperative RT/CCRT in pN1 with ENE OSCC patients. METHODS: Clinicopathological data and treatment modalities were investigated. The evaluated endpoints were overall survival (OS) and type of recurrence. RESULTS: The 3-year cumulative OS rates for the pN1 only, multiple lymph node metastasis (MLM) only, ENE + MLM, and ENE + pN1 groups were 77.2%, 66.8%, 43.3%, and 66.6%, respectively. In the ENE + pN1 group, the most common cause of death in the surgery only group was from regional failure. The surgery + RT/CCRT group was associated with better disease-specific survival and OS rates than the surgery only groups (P < 0.05). CONCLUSIONS: The prognosis of ENE + pN1 was not as poor as that of ENE + MLM, although both these groups feature ENE. Adjuvant therapy (RT/CCRT) after surgery is recommend for cases of ENE + pN1.

  Jun. 2018, J Surg Oncol, 117(8) (8), 1736 - 1743, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Four-Dimensional Computed Tomography Evaluation of Condylar Movement in a Patient With Temporomandibular Joint Osteoarthritis

  Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori

  W.B. Saunders, Feb. 2018, Journal of Oral and Maxillofacial Surgery, 76(2) (2), 304 - 313, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Treatment modalities and risk factors associated with refractory neurosensory disturbances of the inferior alveolar nerve following oral surgery: a multicentre retrospective study

  Hasegawa Takumi, YamadaSI, UedaN, SoutomeS, FunaharaM, AkashiM, FurunoS, MiyamotoH, HayashidaS, AmanoR, MoriK, KojimaY, KuritaH, KiritaT, UmedaM, ShibuyaY, FujitaS, Komori Takahide

  Jan. 2018, Int J Oral Maxillofac Surg, 47(6) (6), 794 - 801, English

  [Refereed]

  Scientific journal


• Association between pain severity and clinicohistopathologic findings in the mandibular canal and inferior alveolar nerve of patients with advanced mandibular osteoradionecrosis

  Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

  Mosby Inc., 2018, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(3) (3), 264 - 71, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The risk factors associated with postoperative hemorrhage after tooth extraction: a multi-center retrospective study of patients receiving oral antithrombotic therapy

  Takumi Hasegawa, Souichi Yanamoto, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Michinori Maeda, Takahide Komori, Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)

  Springer Verlag, Dec. 2017, Oral and Maxillofacial Surgery, 21(4) (4), 397 - 404, English

  [Refereed]

  Scientific journal


• A Case Series of Fibro-Osseous Lesions of the Jaws.

  AKASHI MASAYA, Matsuo K, SHIGEOKA MANABU, KAKEI YASUMASA, HASEGAWA TAKUMI, Tachibana A, FURUDOI SHUNGO, KOMORI TAKAHIDE

  The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.

  Dec. 2017, Kobe J Med Sci, 63(3) (3), E73 - 79, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Axial four-dimensional computed tomographic images to analyze crosswise differences in protrusive condylar movement in patients who underwent mandibulectomy and free flap reconstruction

  Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

  Nov. 2017, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45(11) (11), 1778 - 1783, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 早期舌扁平上皮癌における頸部後発転移の新たな予測因子の検討

  山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘

  (一社)日本癌治療学会, Oct. 2017, 日本癌治療学会学術集会抄録集, 55回, PS - 1, Japanese


• Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis.

  Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda

  Oct. 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 32(10) (10), 2022 - 2029, English, International magazine

  [Refereed]

  Scientific journal


• Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC

  YamadaSI, OtsuruM, YanamotoS, Hasegawa Takumi, AizawaH, KamataT, YamakawaN, KohgoT, ItoA, NodaY, HiraiC, KitamuraT, OkuraM, KiritaT, UedaM, YamashitaT, OtaY, Komori Takahide, UmedaM, KuritaH

  OBJECTIVES: The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined. PATIENTS AND METHODS: The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis. RESULTS: ECS was detected in 216 cases of OSCC and analyzed. The 5-year overall survival and RFS rates of patients with type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, were significantly poor at 40.6 and 37.8%, respectively. The results of a univariate analysis suggested that the prognosis of ECS in OSCC patients is associated with its progression level, particularly type C. The 5-year RFS rate of type C with tumor budding was significantly poor at 31.5%. Type C with tumor budding correlated with local and regional recurrence as well as distant metastasis. In a multivariate analysis, tumor budding was identified as an independent prognostic factor. CONCLUSIONS: These results suggest that the progression level of ECS and tumor budding are useful prognostic factors in OSCC patients. CLINICAL RELEVANCE: This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.

  Oct. 2017, Clin Oral Investig, 22(3) (3), 1311 - 1318, English, International magazine

  [Refereed]

  Scientific journal


• Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis

  Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda

  Oct. 2017, JOURNAL OF BONE AND MINERAL RESEARCH, 32(10) (10), 2022 - 2029, English

  [Refereed]

  Scientific journal


• インプラント周囲に放射線性顎骨壊死を生じ保存的に治療した1例

  明石昌也, 鰐渕聡, 岩田英治, 筧康正, Hasegawa Takumi, 鈴木泰明, Komori Takahide

  (公社)日本顎顔面インプラント学会, Aug. 2017, Japanese Journal of Maxillo Facial Implants, 16(2) (2), 75 - 80, Japanese

  [Refereed]

  Scientific journal


• Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study

  Yuka Kojima, Souichi Yanamoto, Masahiro Umeda, Yumiko Kawashita, Izumi Saito, Takumi Hasegawa, Takahide Komori, Nobuhiro Ueda, Tadaaki Kirita, Shin-ichi Yamada, Hiroshi Kurita, Yasuko Senga, Yasuyuki Shibuya, Hiroshi Iwai

  Aug. 2017, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 124(2) (2), 139 - 145, English

  [Refereed]

  Scientific journal


• Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery A multicenter case-control study with propensity score matching analysis

  Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Shin-ichi Yamada, Hiroshi Kurita, Chika Yamauchi, Yasuyuki Shibuya, Yuka Kojima, Hirokazu Nakahara, Takahiko Oho, Masahiro Umeda

  Aug. 2017, MEDICINE, 96(33) (33), e7436, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Changes in cell junctions induced by inhibition of epidermal growth factor receptor in oral squamous cell carcinoma cells

  Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori

  Aug. 2017, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 14(2) (2), 953 - 960, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ?

  T. Hasegawa, A. Kawakita, N. Ueda, R. Funahara, A. Tachibana, M. Kobayashi, E. Kondou, D. Takeda, Y. Kojima, S. Sato, S. Yanamoto, H. Komatsubara, M. Umeda, T. Kirita, H. Kurita, Y. Shibuya, T. Komori

  Aug. 2017, OSTEOPOROSIS INTERNATIONAL, 28(8) (8), 2465 - 2473, English

  [Refereed]

  Scientific journal


• ARONJの新たな医科歯科連携 抜歯と骨吸収抑制薬関連性顎骨壊死に関する多施設共同後ろ向き研究 抜歯前休薬の有無と術中処置について

  長谷川 巧実, 川北 晃子, 上田 順宏, 橘 進彰, 小林 正樹, 近藤 英司, 小松原 秀紀, 兒島 由佳, 佐藤 隼, 梅田 正博, 桐田 忠昭, 栗田 浩, 渋谷 恭之, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 81 - 81, Japanese


• ARONJの新たな医科歯科連携 薬剤関連顎骨壊死(MRONJ)の治療成績に影響する因子に関する多施設共同後ろ向き観察研究

  林田 咲, 柳本 惣市, 藤田 茂之, 長谷川 巧実, 古森 孝英, 兒島 由佳, 上田 順宏, 桐田 忠昭, 宮本 大模, 渋谷 恭之, 篠原 光代, 中原 寛和, 梅田 正博

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 81 - 82, Japanese


• 早期舌癌における再発予測因子としてのTumor Buddingの検討

  山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣市, 太田 嘉英, 大鶴 光信, 大倉 正也, 相川 友直, 栗田 浩, 山田 慎一, 古森 孝英, 長谷川 巧実, 上田 倫弘

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 110 - 111, Japanese


• Multicenter Retrospective Study of the Risk Factors of Hemorrhage After Tooth Extraction in Patients Receiving Antiplatelet Therapy

  Souichi Yanamoto, Takumi Hasegawa, Satoshi Rokutanda, Sayaka Komori, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Yasuyuki Shibuya, Hiroshi Kurita, Takahide Komori, Masahiro Umeda

  Jul. 2017, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75(7) (7), 1338 - 1343, English

  [Refereed]

  Scientific journal


• Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer

  Akashi Masaya, TeraokaS, KakeiY, KusumotoJ, Hasegawa Takumi, MinamikawaT, Hashikawa Kazunobu, Komori Takahide

  BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.

  Jul. 2017, Lymphat Res Biol, 16(2) (2), 147 - 153, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 下顎関節突起に転移した腎盂尿管癌の1例

  武田大介, Hasegawa Takumi, Hinata Nobuyuki, Shigeoka Manabu, 小林正樹, 小松原秀紀, MINAMIKAWA TSUTOMU, Komori Takahide

  (一社)日本口腔腫瘍学会, Jun. 2017, 日本口腔腫瘍学会誌, 29(2号) (2号), 45 - 51, Japanese

  [Refereed]

  Scientific journal


• Single-stage reconstruction for buccal mucosa tumor resection including the labial commissure using a facial artery musculomucosal flap and a vermilion advancement flap

  SakakibaraA, Matsumoto Kousuke, Hasegawa Takumi, MinamikawaT, Komori Takahide

  Resection of buccal mucosa tumors may occasionally involve the labial angle and peripheral skin. Reconstruction is required when the resection involves more than one-third of the lip. We describe a single-stage reconstruction using a facial artery musculomucosal (FAMM) flap and a vermilion advancement flap after buccal mucosa resection including the labial angle. A 62-year-old woman with carcinoma in situ of the buccal mucosa underwent tumor resection. The resection included the right labial angle and peripheral skin. The resection did not lead to a massive lip defect, but a wide defect resulted on the mucosal side. The defect on the mucosal side was reconstructed using a FAMM flap, while the vermilion defect was covered using a vermilion advancement flap. Reconstruction performed using the FAMM flap and vermilion advancement flap produced aesthetically and functionally satisfactory outcomes.

  Jun. 2017, J Surg Case Rep, 2017(6) (6), rjx108, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Increase in carbon dioxide accelerates the performance of endurance exercise in rats

  UehaT, MiwaM, Hasegawa Takumi, NishimotoH, LeeSY, Niikura Takahiro, KurosakaM, Kuroda Ryosuke, Sakai Yoshitada

  Endurance exercise generates CO2 via aerobic metabolism; however, its role remains unclear. Exogenous CO2 by transcutaneous delivery promotes muscle fibre-type switching to increase endurance power in skeletal muscles. Here we determined the performance of rats running in activity wheels with/without transcutaneous CO2 exposure to clarify its effect on endurance exercise and recovery from muscle fatigue. Rats were randomised to control, training and CO2 groups. Endurance exercise included activity-wheel running with/without transcutaneous CO2 delivery. Running performance was measured after exercise initiation. We also analysed changes in muscle weight and muscle fibres in the tibialis anterior muscle. Running performance improved over the treatment period in the CO2 group, with a concomitant switch in muscle fibres to slow-type. The mitochondrial DNA content and capillary density in the CO2 group increased. CO2 was beneficial for performance and muscle development during endurance exercise: it may enhance recovery from fatigue and support anabolic metabolism in skeletal muscles.

  Jun. 2017, J Physiol Sci, 68(4) (4), 463 - 470, English, Domestic magazine

  [Refereed]

  Scientific journal


• 顎顔面形態と下顎枝の形状および骨密度に関する検討

  塩屋園 敦, 立石 千鶴, 長谷川 巧実, 岡本 奈那, 松本 耕祐, 鈴木 泰明, 古土井 春吾, 古森 孝英

  (NPO)日本顎変形症学会, May 2017, 日本顎変形症学会雑誌, 27(2) (2), 125 - 125, Japanese


• 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究

  明石 昌也, 楠元 順哉, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英

  (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 189 - 189, Japanese


• Postoperative drainage in head and neck surgery for oral cancer

  Izumi Saito, Takumi Hasegawa, Eiji Iwata, Natsuki Yonezawa, Satomi Arimoto, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Elsevier Ltd, May 2017, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(3) (3), 217 - 221, English

  [Refereed]

  Scientific journal


• Retrospective study of treatment outcomes after postoperative chemoradiotherapy in Japanese oral squamous cell carcinoma patients with risk factors of recurrence

  Takumi Hasegawa, Souichi Yanamoto, Mitsunobu Otsuru, Shin-ichi Yamada, Tsutomu Minamikawa, Takashi Shigeta, Tomofumi Naruse, Takatsugu Suzuki, Masashi Sasaki, Yoshihide Ota, Masahiro Umeda, Takahide Komori

  Mosby Inc., May 2017, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 123(5) (5), 524 - 530, English

  [Refereed]

  Scientific journal


• Induced pluripotent-stem-cell related genes contribute to de-differentiation in oral squamous cell carcinoma

  Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Eiji Iwata, Risa Harada, Akiko Sakakibara, Teruya Kawamoto, Tsutomu Minamikawa, Yoshitada Sakai, Takahide Komori

  Mar. 2017, Anticancer Research, 37(3) (3), 1075 - 1082, English, International magazine

  [Refereed]

  Scientific journal


• Survival of Branemark System Mk III implants and analysis of risk factors associated with implant failure

  T. Hasegawa, S. Kawabata, D. Takeda, E. Iwata, I. Saito, S. Arimoto, A. Kimoto, M. Akashi, H. Suzuki, T. Komori

  Feb. 2017, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 46(2) (2), 267 - 273, English

  [Refereed]

  Scientific journal


• Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery: A multicenter case-control study with propensity score matching analysis.

  Soutome Sakiko, Yanamoto Souichi, Funahara Madoka, Hasegawa Takumi, Komori Takahide, Yamada Shin-ichi

  2017, Medicine, 96(e7436) (e7436), English

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking

  Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

  Jan. 2017, PLOS ONE, 12(1) (1), e0169723, English

  [Refereed]

  Scientific journal


• Prognosis of oral squamous cell carcinoma patients with level IV/V metastasis: An observational study

  Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Jan. 2017, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45(1) (1), 145 - 149, English

  [Refereed]

  Scientific journal


• Temporal evaluation of neurosensory complications after mandibular third molar extraction: Current problems for diagnosis and treatment

  Masaya Akashi, Yujiro Hiraoka, Takumi Hasegawa, Takahide Komori

  Bentham Science Publishers B.V., Dec. 2016, Open Dentistry Journal, 10, 728 - 732, English

  [Refereed]

  Scientific journal


• Prognostic and staging implications of mandibular canal invasion in lower gingival squamous cell carcinoma.

  Okura M, Yanamoto S, Umeda M, Otsuru M, Ota Y, Kurita H, Kamata T, Kirita T, Yamakawa N, Yamashita T, Ueda M, Komori T, Hasegawa T, Aikawa T, Japan Oral, Oncology Group

  A multi-institutional study was undertaken to determine whether mandibular canal (MC) invasion and mandibular medullary bone invasion are independent factors in lower gingival squamous cell carcinoma (SCC). A total of 345 patients with lower gingival SCC were retrospectively reviewed. Mandibular bone invasion was categorized into three types; no bone invasion; invasion through cortical bone (medullary); and MC invasion. The overall survival rate and factors affecting local, regional, and distant failures were assessed by Cox proportional hazards regression analysis and Kaplan-Meier estimates. Bone invasion was present in 201 (58%) patients, of whom 107 (31%) had medullary invasion and 94 (27%) had MC invasion. Using the International Union Against Cancer (UICC) staging system and American Joint Committee on Cancer (AJCC) system, 171 (50%) patients were classified as T4a. When the bone invasion criteria were excluded from the UICC/AJCC system definition, 152 T4a tumors were downstaged and reclassified to T1 in 12 (3%), to T2 in 98 (28%), and to T3 in 42 (12%). In Cox multivariate analysis, MC invasion was an independent predictor of overall survival but medullary bone invasion was not. Medullary bone invasion was an independent variable for distant control. The current T staging system has restricted prognostic utility. The authors recommend a modified T staging system, whereby tumors with MC invasion instead of medullary bone invasion are classified as T4a, and tumors are first classified as T1 to T3 based on size and then upstaged by one T classification in the presence of medullary invasion.

  Dec. 2016, Cancer medicine, 5(12) (12), 3378 - 3385, English, International magazine

  [Refereed]

  Scientific journal


• 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

  片岡 侑嗣, 長谷川 巧実, 綿越 健太, 浅井 雅敏, 有本 智美, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2016, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 218 - 218, Japanese


• T1-2N0M0舌扁平上皮癌の検討

  大鶴 光信, 太田 嘉英, 柳本 惣市, 大倉 正也, 梅田 正博, 桐田 忠明, 栗田 浩, 上田 倫弘, 長谷川 巧実, 柴原 孝彦, 野口 忠秀, 野口 一馬, 山下 善弘, 大廣 洋一, 内藤 博之

  (一社)日本癌治療学会, Oct. 2016, 日本癌治療学会学術集会抄録集, 54回, PS - 2, Japanese


• Comparison between primary closure and skin grafts of the free fibula osteocutaneous flap donor site

  Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori

  Springer Verlag, Sep. 2016, Oral and Maxillofacial Surgery, 20(3) (3), 233 - 237, English

  [Refereed]

  Scientific journal


• Preventive Effect on Post-Operative Pneumonia of Oral Health Care among Patients Who Undergo Esophageal Resection: A Multi-Center Retrospective Study

  Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Takahiko Oho, Masahiro Umeda

  Aug. 2016, SURGICAL INFECTIONS, 17(4) (4), 479 - 484, English

  Scientific journal


• 顎関節周囲違和感を伴う顔面非対称症例に対し外科的矯正治療を行った53歳女性の1例

  塩屋園敦, 立石千鶴, 長谷川巧実, 竹内純一郎, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班

  (NPO)日本顎変形症学会, Aug. 2016, 日本顎変形症学会雑誌, 26(3号) (3号), 243 - 254, Japanese

  [Refereed]

  Scientific journal


• Decreased mitochondrial copy numbers in oral squamous cell carcinoma

  Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Akiko Sakakibara, Teruya Kawamoto, Tsutomu Minamikawa, Yoshitada Sakai, Takahide Komori

  Aug. 2016, HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 38(8) (8), 1170 - 1175, English

  [Refereed]

  Scientific journal


• 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

  平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, Japanese


• 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

  中西 洋介, 松本 耕祐, 小守 紗也華, 長谷川 巧実, 明石 昌也, 柚鳥 宏和, 橘 進彰, 古森 孝英

  (一社)日本外傷歯学会, Jul. 2016, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, Japanese


• 抗血栓療法患者の抜歯後出血危険因子についての多施設共同研究

  柳本 惣市, 長谷川 巧実, 小守 紗也華, 渋谷 恭之, 橘 進彰, 兒島 由佳, 小山 吉人, 栗田 浩, 古森 孝英, 梅田 正博

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 176 - 176, Japanese


• 下顎骨偏位と乳様突起体積および頭位に関する検討

  塩屋園 敦, 立石 千鶴, 浅井 雅敏, 有本 智美, 岡本 奈那, 長谷川 巧実, 鈴木 泰明, 古土井 春吾, 古森 孝英

  (NPO)日本顎変形症学会, May 2016, 日本顎変形症学会雑誌, 26(2) (2), 181 - 181, Japanese


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  明石 昌也, 橋川 和信, 鰐渕 聡, 楠元 順哉, 長谷川 巧実, 南川 勉, 寺師 浩人, 古森 孝英

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 147 - 147, Japanese


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本 智美, 長谷川 巧実, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英

  (NPO)日本顎変形症学会, May 2016, 日本顎変形症学会雑誌, 26(2) (2), 183 - 183, Japanese


• 口腔扁平上皮癌における術後補助療法の指標となる頸部リンパ節転移の被膜外浸潤の進展度分類の検討

  山田 慎一, 大鶴 光信, 柳本 惣市, 長谷川 巧実, 鎌田 孝広, 相澤 仁志, 山川 延宏, 高後 友之, 伊藤 章, 大倉 正也

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 169 - 169, Japanese


• 下歯肉がんのT分類(多施設共同後ろ向き研究JOOG RA-1401)

  大倉 正也, 伊藤 章, 太田 嘉英, 大鶴 光信, 梅田 正博, 柳本 惣市, 桐田 忠昭, 山川 延宏, 長谷川 巧実, 古森 孝英, 栗田 浩, 鎌田 孝広, 山下 徹郎, 上田 倫弘

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 179 - 179, Japanese


• 口腔癌病理学的再発高リスク例に対する術後補助療法の検討

  長谷川 巧実, 大鶴 光信, 柳本 惣市, 鳴瀬 智史, 南川 勉, 太田 嘉英, 梅田 正博, 古森 孝英

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 204 - 204, Japanese


• Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study

  Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori

  May 2016, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 44(5) (5), 637 - 641, English

  [Refereed]

  Scientific journal


• Transcutaneous carbon dioxide suppresses epithelial-mesenchymal transition in oral squamous cell carcinoma.

  Eiji Iwata, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Takahide Komori

  Oral squamous cell carcinoma (OSCC) is the most common form of oral cancers. Recent studies have shown that the malignant transformation of various carcinomas, including OSCC, is associated with epithelial-mesenchymal transition (EMT), and that expression of the EMT factors are significantly associated with tumor invasion, tumor metastasis, and survival rates in OSCC patients. Hence, there is a possibility that EMT suppression may improve the prognosis of OSCC patients. Hypoxia inducible factor-1α (HIF-1α) is a crucial microenvironmental factor in tumor progression, which induces the expression of EMT factors. We previously reported that transcutaneous CO2 suppresses both human OSCC tumor growth and metastasis to the regional lymph nodes by improving hypoxia in treated tissue. According to this background, we hypothesized that increased EMT with HIF-1α expression may increase the progression and the metastatic potential of OSCC, and that decreased hypoxia by transcutaneous CO2 could suppress EMT. In the present study, in vitro studies showed that hypoxic conditions increased the expression of HIF-1α and EMT factors in OSCC cells. In addition, in vivo studies revealed that transcutaneous CO2 increased E-cadherin expression with the decreased expression of HIF-1α, Snail, Slug, N-cadherin, and Vimentin in tumor treatment. These results suggest that transcutaneous CO2 could suppress EMT by improving hypoxia, resulting in the reduction of metastatic potential of OSCC. The findings indicate that transcutaneous CO2 may be able to improve the prognosis of OSCC patients through the suppression of EMT.

  Apr. 2016, International journal of oncology, 48(4) (4), 1493 - 8, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

  難波 渚, 西井 美佳, 田村 恵利, 富田 和, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

  (一社)日本口腔ケア学会, Mar. 2016, 日本口腔ケア学会雑誌, 10(1) (1), 199 - 199, Japanese


• 当院における周術期口腔機能管理に関する実態調査と今後の課題

  田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

  (一社)日本口腔ケア学会, Mar. 2016, 日本口腔ケア学会雑誌, 10(1) (1), 225 - 225, Japanese


• Evaluation of the level of progression of extracapsular spread for cervical lymph node metastasis in oral squamous cell carcinoma

  S. Yamada, S. Yanamoto, S. Otani, T. Hasegawa, M. Miyakoshi, T. Minamikawa, N. Ohga, T. Kamata, T. Komori, Y. Kitagawa, H. Kurita, M. Umeda

  Feb. 2016, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 45(2) (2), 141 - 146, English

  [Refereed]

  Scientific journal


• Meaning and limitation of cortical bone width measurement with DentaScan in medication-related osteonecrosis of the jaws

  Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori

  Kobe University School of Medicine, 2016, Kobe Journal of Medical Sciences, 62(5) (5), E114 - E119, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 多施設共同後ろ向き研究による検証.

  五月女さき子, 船原まどか, 於保孝彦, 山田慎一, 栗田 浩, 山内千佳, 渋谷恭之, 兒島由, 佳, 長谷川巧実, 古森孝英, 梅田正博

  2016, 日本口腔科学会誌, 65, 324-329

  [Refereed]


• Postradiotherapy Dental Implant Insertion Into Bone Grafts Harvested From Nonirradiated Tissue: Case Reports

  Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori

  2016, IMPLANT DENTISTRY, 25(5) (5), 715 - 719, English

  [Refereed]

  Scientific journal


• A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy.

  Akashi M, Shibuya Y, Takahashi Y, Kusumoto J, Sakakibara A, Hasegawa T, Minamikawa T, Hashikawa K, Komori T

  2016, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology., 28, 111 - 117, Japanese

  [Refereed]

  Scientific journal


• Incidence of Venous Thromboembolism After Oral Oncologic Surgery With Simultaneous Reconstruction

  Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Tsutomu Minamikawa, Satoshi Usami, Takahide Komori

  Jan. 2016, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 74(1) (1), 212 - 217, English

  [Refereed]

  Scientific journal


• ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症

  有本智美, Hasegawa Takumi, 斉藤泉, 岩田英治, 武田大介, Akashi Masaya, Suzuki Yasuaki, 古土井春吾, Komori Takahide

  Nov. 2015, Japanese Journal of Maxillo Facial Implants, 14(3号) (3号), 261, Japanese

  Research society


• CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible

  Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori

  Oct. 2015, IMPLANT DENTISTRY, 24(5) (5), 541 - 546, English

  [Refereed]

  Scientific journal


• 頭頸・口腔 口腔がん治療の個別化を目指して 下歯肉・下顎癌のUICC分類と下顎管分類に関する多施設共同後ろ向き研究JOOG RA-1401

  大倉 正也, 相川 友直, 太田 嘉英, 大鶴 光信, 梅田 正博, 柳本 惣市, 桐田 忠昭, 山川 延宏, 栗田 浩, 鎌田 孝広, 長谷川 巧実, 古森 孝英, 山下 徹郎, 上田 倫弘

  (一社)日本癌治療学会, Sep. 2015, 日本癌治療学会誌, 50(3) (3), 2196 - 2196, Japanese


• 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

  村田陽太郎, Hasegawa Takumi, 八橋明子, Akashi Masaya, Minamikawa Tsutomu, 古土井春吾, Komori Takahide

  Sep. 2015, 日本口腔科学会雑誌, 64(3号) (3号), 301, Japanese

  Research society


• Risk factors associated with postoperative delirium after surgery for oral cancer

  Takumi Hasegawa, Izumi Saito, Daisuke Takeda, Eiji Iwata, Natsuki Yonezawa, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Sep. 2015, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 43(7) (7), 1094 - 1098, English

  [Refereed]

  Scientific journal


• Sequential evaluation for bone union of transferred fibula flaps in reconstructed mandibles: panoramic X-ray versus computed tomography

  M. Akashi, K. Hashikawa, Y. Kakei, A. Sakakibara, T. Hasegawa, T. Minamikawa, T. Komori

  Aug. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 942 - 947, English

  [Refereed]

  Scientific journal


• Determining the location of the internal maxillary artery on ultrasonography and unenhanced magnetic resonance imaging before orthognathic surgery

  S. Arimoto, T. Hasegawa, N. Okamoto, A. Shioyasono, C. Tateishi, M. Akashi, H. Suzuki, S. Furudoi, T. Komori

  Aug. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 977 - 983, English

  [Refereed]

  Scientific journal


• Low-intensity pulsed ultrasound enhances bone morphogenetic protein expression of human mandibular fracture haematoma-derived cells

  W. Huang, T. Hasegawa, Y. Imai, D. Takeda, M. Akashi, T. Komori

  Jul. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7) (7), 929 - 935, English

  [Refereed]

  Scientific journal


• 口腔癌患者への緩和ケアチームの介入に関する臨床的検討

  米澤奈津季, Minamikawa Tsutomu, 高橋佑輔, 榊原晶子, Hasegawa Takumi, 重田崇至, 渋谷恭之, Komori Takahide

  We examined the effect of the intervention by a palliative care team (PCT) for patients with oral cancer. This study was performed in the Department of Oral and Maxillofacial Surgery at Kobe University Hospital from January 2008 to October 2012. 36 of 194 patients needed intervention by the PCT. 71.1% of them suffered from pain, insomnia, and anxiety. We assessed their symptoms using the Japanese version of the Support Team Assessment Schedule (STAS-J). When the PCT intervention finished, 13 of 22 symptoms had significantly improved and 8 had improved. It was shown that the intervention of the PCT was very effective. Most of the oral cancer patients are troubled with a change of the postoperative countenance, dysarthria, and dysphagia. To relieve cancer patients of their total symptoms, we have to cooperate with the PCT from an early stage of the cancer treatment.

  Japanese Society of Oral Oncology, Jun. 2015, 日本口腔腫瘍学会誌, 27(2号) (2号), 13 - 20, Japanese

  [Refereed]

  Scientific journal


• Risk Factors Associated with Distant Metastasis in Patients with Oral Squamous Cell Carcinoma

  Takumi Hasegawa, Makiko Tanakura, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  Jun. 2015, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 152(6) (6), 1053 - 1060, English

  [Refereed]

  Scientific journal


• Facial emphysema after sinus lift

  SakakibaraA, Suzuki Yasuaki, YamashitaA, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  Jun. 2015, J Surg Case Rep, 6, 1 - 4, English

  [Refereed]

  Scientific journal


• Does Salivary Duct Repositioning Prevent Complications After Tumor Resection or Salivary Gland Surgery?

  Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori

  May 2015, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73(5) (5), 1003 - 1007, English

  [Refereed]

  Scientific journal


• 抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例

  岩田英治, Akashi Masaya, Hasegawa Takumi, 古土井春吾, Komori Takahide

  (一社)日本口腔感染症学会, May 2015, 日本口腔感染症学会雑誌, 22(1号) (1号), 41 - 42, Japanese

  Research society


• 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化

  定兼啓倫, Hasegawa Takumi, 有本智美, 岡本奈々, 塩屋園敦, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, 古土井春吾, Komori Takahide

  May 2015, 日本顎変形症学会雑誌, 25(2号) (2号), 117, Japanese

  Research society


• 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

  有本智美, Hasegawa Takumi, 定兼啓倫, 岡本奈々, 塩屋園敦, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, 古土井春吾, Komori Takahide

  May 2015, 日本顎変形症学会雑誌, 25(2号) (2号), 134, Japanese

  Research society


• Postoperative abnormal response of C-reactive protein as an indicator for infectious complications after oral oncologic surgery with primary reconstruction

  Masaya Akashi, Shungo Furudoi, Kazunobu Hashikawa, Akiko Sakakibara, Takumi Hasegawa, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

  Apr. 2015, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 13, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Retrospective study of changes in the sensitivity of the oral mucosa: sagittal split ramus osteotomy (SSRO) versus intraoral vertical ramus osteotomy (IVRO).

  T Hasegawa, C Tateishi, M Asai, Y Imai, N Okamoto, A Shioyasono, A Kimoto, M Akashi, H Suzuki, S Furudoi, T Komori

  We investigated changes in the sensitivity of cutaneous points and the oral mucosa after sagittal split ramus osteotomy (SSRO) and assessed the differences between SSRO and intraoral vertical ramus osteotomy (IVRO). The subjects included in this study were 46 patients with mandibular prognathism who underwent IVRO (88 rami) and 30 patients who underwent SSRO (59 rami). An objective evaluation of the neurosensory status of each patient was completed preoperatively and at 1, 4, 8, 12, and 24 weeks postoperatively. Other variables studied for each patient included sex, age, magnitude of mandibular setback, and amount of blood loss during surgery. We found that a neurosensory recovery occurred earlier in the oral mucosa than at cutaneous points. The number of oral mucosa points showing reduced neurosensory function and neurosensory disturbance after SSRO was significantly higher than after IVRO at 1, 4, and 8 weeks (P<0.05). The nerve recovery observed after SSRO was delayed for a longer period than that noted in our previous study of IVRO. In conclusion, we found changes in sensitivity at cutaneous points and the oral mucosa after SSRO and assessed the differences between SSRO and IVRO.

  Mar. 2015, International journal of oral and maxillofacial surgery, 44(3) (3), 349 - 55, English, International magazine

  [Refereed]

  Scientific journal


• The osteogenic activity of human mandibular fracture haematoma-derived progenitor cells is affected by bisphosphonate in vitro

  Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, T. Komori

  Mar. 2015, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 412 - 416, English

  [Refereed]

  Scientific journal


• 後方への進展なくルビエールリンパ節に転移を生じた口腔癌2例

  重田崇至, Minamikawa Tsutomu, Akashi Masaya, Hasegawa Takumi, 榊原晶子, 松井太輝, 筧康正, 高橋佑輔, 渋谷恭之, 梅田正博, Komori Takahide

  (一社)日本口腔腫瘍学会, Mar. 2015, 日本口腔腫瘍学会誌, 27(1) (1), 1 - 6, Japanese

  [Refereed]

  Scientific journal


• Spindle cell carcinoma of the oral cavity: The impact of chemotherapy on pulmonary metastatic tumor doubling time

  Takashi Shigeta, Tsutomu Minamikawa, Taiki Matsui, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Akiko Sakakibara, Yasuyuki Shibuya, Takahide Komori

  Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(3) (3), E64 - E70, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw

  ImaiY, Hasegawa Takumi, TakedaD, KusumotoJ, Akashi Masaya, LeeSY, FurudoiS, Komori Takahide

  2015, J Oral Maxillofac Surg Med Pathol, English

  [Refereed]

  Scientific journal


• Clinical study of 19 cases resulting in dental implant removal

  Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori

  Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(4) (4), E102 - E108, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例

  藤田剛史, 井堂信二郎, 大槻有美, 江崎友美, Hasegawa Takumi, Komori Takahide

  Jan. 2015, 日本口腔外科学会雑誌, 61(1号) (1号), 25 - 30, Japanese

  [Refereed]

  Scientific journal


• 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

  今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 128 - 128, Japanese


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例

  榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, Japanese


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, Japanese


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, Japanese


• ゾレドロネート反復投与による創傷治癒遅延の予防、治療法に関する研究

  Komori Takahide, 長谷川 巧実, 今井 佑輔, 武田 大介, 浅井 雅敏

  Oct. 2014, Osteoporosis Japan, 22(4) (4), 706 - 709, Japanese

  Scientific journal


• 舌背部に生じた顆粒細胞腫の1例

  岩田 英治, Hasegawa Takumi, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  (一社)日本口腔診断学会, Oct. 2014, 日本口腔診断学会雑誌, 27(3号) (3号), 253 - 256, Japanese

  [Refereed]

  Scientific journal


• 口蓋に発生した嚢胞腺癌の1例

  高田 直樹, Shibuya Yasuyuki, Hasegawa Takumi, Kimoto Akira, 鈴木 泰明, Komori Takahide

  Cystadenocarcinoma is an uncommon salivary gland tumor that occurs in the palate. We report a rare case of cystadenocarcinoma arising in the palate. A 80-year-old man visited a certain hospital because of a painless swelling in the palate. A biopsy was performed, and adenocarcinoma was diagnosed histopathologically. He was therefore referred to our hospital to receive treatment for adenocarcinoma. He had a painless swelling, measuring 25 × 15 mm, in the left side of the palate. Computed tomography showed no evidence of cervical metastasis. Partial maxillectomy was performed, and the final histopathological diagnosis was cystadenocarcinoma. There was no evidence of recurrence or metastasis 20 months after the operation.

  Japanese Society of Oral and Maxillofacial Surgeons, Oct. 2014, 日本口腔外科学会雑誌, 60(10号) (10号), 561 - 565, Japanese

  [Refereed]

  Scientific journal


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英

  (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, Japanese


• Two cases of posterior open bite caused by the thickness of retrodiscal tissue in the temporomandibular joint

  T. Hasegawa, Y. Shibuya, T. Minamikawa, T. Komori

  Sep. 2014, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(9) (9), 1104 - 1107, English

  [Refereed]

  Scientific journal


• Alteration of Cell-Cell Junctions in Cultured Human Lymphatic Endothelial Cells with Inflammatory Cytokine Stimulation

  Yasumasa Kakei, Masaya Akashi, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

  Sep. 2014, LYMPHATIC RESEARCH AND BIOLOGY, 12(3) (3), 136 - 143, English

  [Refereed]

  Scientific journal


• 周術期のD2受容体阻害薬投与が誘因となり急性ジストニアを発症したと考えられた顎変形症患者の1例

  柳田 匡彦, Furudoi Shungo, 立石 千鶴, Hasegawa Takumi, Shibuya Yasuyuki, Komori Takahide

  Aug. 2014, 日本顎変形症学会雑誌, 24(3号) (3号), 253 - 258, Japanese

  [Refereed]

  Scientific journal


• Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo

  Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Yusuke Imai, Akiko Sakakibara, Masaya Minoda, Teruya Kawamoto, Tsutomu Minamikawa, Yasuyuki Shibuya, Toshihiro Akisue, Yoshitada Sakai, Masahiro Kurosaka, Takahide Komori

  Jul. 2014, PLOS ONE, 9(7) (7), e100530, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study

  Nishii M, Akashi Masaya, Kakei Y, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Takahashi M, Ohtsuki Naoki, Nibu Ken-ichi, Komori Takahide

  Jun. 2014, Oral Health Dent Manag, 13(2) (2), 507 - 11, English

  [Refereed]

  Scientific journal


• 顎矯正手術における超音波診断法と単純MRI画像を用いた顎動脈の走行位置評価

  有本 智美, 長谷川 巧実, 金子 児太郎, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 古土井 春吾, 渋谷 恭之, 古森 孝英

  (NPO)日本顎変形症学会, May 2014, 日本顎変形症学会雑誌, 24(2) (2), 115 - 115, Japanese


• Oral squamous cell carcinoma with microscopic extracapsular spread in the cervical lymph nodes

  Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori

  Apr. 2014, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(4) (4), 387 - 392, English

  [Refereed]

  Scientific journal


• The osteogenic activity of human mandibular fracture haematoma-derived cells is stimulated by low-intensity pulsed ultrasound in vitro

  Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori

  Mar. 2014, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(3) (3), 367 - 372, English

  [Refereed]

  Scientific journal


• Retrospective study of ameloblastoma: the possibility of conservative treatment.

  Takumi Hasegawa, Yusuke Imai, Daisuke Takeda, Daisuke Yasuoka, Shinshou Ri, Takashi Shigeta, Tsutomu Minamikawa, Yasuyuki Shibuya, Takahide Komori

  At our institutions, most cases of the solid or multicystic type were treated as conservatively as possible in order to avoid disadvantages of radical treatment. The aim of present study was to retrospectively analyze the ameloblastoma cases diagnosed at our two institutions, to classify them according to the criteria of the 2005 WHO classification, and to evaluate the possibility of using a conservative approach for the surgical treatment of ameloblastoma. Maxillary cases, unicystic cases, peripheral cases and resection-treated cases were excluded from this study. In 23 tumors of mandibular solid or multicystic ameloblastoma, a patient's age, gender, location, clinical signs, duration, radiographic appearance, preoperative diagnosis, ameloblastoma subtypes, treatment, and recurrence were investigated. The recurrence rate (48.7%) in this study was lower than the reported recurrence rate after conservative treatment for solid or multicystic ameloblastoma and was higher than the reported recurrence rate of ameloblastoma, inclusive of other types. However, all patients who were diagnosed with recurrences have maintained their quality of life and were satisfied for at least several years after the conservative treatment. In conclusion, we demonstrated one possibility that a conservative approach might be employed in the surgical treatment of ameloblastoma (even of the solid or multicystic type).

  Nov. 2013, The Kobe journal of medical sciences, 59(4) (4), E112-21 - 21, English, Domestic magazine

  [Refereed]

  Research institution


• 当科におけるインプラントの撤去に至った20例の臨床的検討

  高端 大希, 鈴木 泰明, Hasegawa Takumi, 石田 優, 竹内 純一郎, 浅井 知子, 渋谷 恭之, 古森 孝英

  Nov. 2013, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 151, Japanese

  Research society


• 下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討

  八橋 明子, 石田 優, 仲村 百合香, 小林 正樹, Hasegawa Takumi, 鈴木 泰明, 渋谷 恭之, 古森 孝英

  Nov. 2013, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 115, Japanese

  Research society


• CT画像における下顎舌側にみられる骨孔の観察

  浅井 知子, 渋谷 恭之, 仲村 百合香, Hasegawa Takumi, 鈴木 泰明, 古森 孝英

  Nov. 2013, Japanese Journal of Maxillo Facial Implants, 12(3号) (3号), 141, Japanese

  Research society


• Changes in the sensitivity of cutaneous points and the oral mucosa after intraoral vertical ramus osteotomy

  T. Hasegawa, C. Tateishi, M. Asano, N. Takata, M. Akashi, T. Shigeta, S. Furudoi, Y. Shibuya, T. Komori

  Nov. 2013, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(11) (11), 1454 - 1461, English

  [Refereed]

  Scientific journal


• Observation of Osseous Healing After Intraoral Vertical Ramus Osteotomy: Focus on Computed Tomography Values

  Satomi Arimoto, Takumi Hasegawa, Kotaro Kaneko, Chizu Tateishi, Shungo Furudoi, Yasuyuki Shibuya, Takahide Komori

  Sep. 2013, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(9) (9), 1602, English

  [Refereed]

  Scientific journal


• Risk factors associated with inferior alveolar nerve injury after extraction of the mandibular third molar-a comparative study of preoperative images by panoramic radiography and computed tomography

  T. Hasegawa, S. Ri, T. Shigeta, M. Akashi, Y. Imai, Y. Kakei, Y. Shibuya, T. Komori

  Jul. 2013, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(7) (7), 843 - 851, English

  [Refereed]

  Scientific journal


• Evaluating the masticatory function after mandibulectomy with colour-changing chewing gum

  Y. Shibuya, S. Ishida, T. Hasegawa, M. Kobayashi, K. Nibu, T. Komori

  Jul. 2013, Journal of Oral Rehabilitation, 40(7) (7), 484 - 490, English

  [Refereed]

  Scientific journal


• 外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例

  浅井 雅敏, 立石 千鶴, 山本 奈那, Hasegawa Takumi, 筧 康正, 竹内 純一郎, 古土井 春吾, Shibuya Yasuyuki, 古森 孝英

  (NPO)日本顎変形症学会, May 2013, 日本顎変形症学会雑誌, 23(2) (2), 174 - 174, Japanese

  Research society


• 下顎枝垂直骨切り術における骨性治癒形態の経時的観察

  金子 児太郎, 立石 千鶴, 今井 佑輔, Hasegawa Takumi, 福岡 裕樹, Furudoi Shungo, 渋谷 恭之, 古森 孝英

  May 2013, 日本顎変形症学会雑誌, 23(2号) (2号), 93, Japanese

  Research society


• 53歳下顎側方偏位症例に対し外科的矯正治療を行った1例

  塩屋園 敦, 立石 千鶴, Hasegawa Takumi, 今井 佑輔, 竹内 純一郎, 鈴木 泰明, Furudoi Shungo, Shibuya Yasuyuki, 古森 孝英

  May 2013, 日本顎変形症学会雑誌, 23(2号) (2号), 174, Japanese

  [Refereed]

  Research society


• Oral Squamous Cell Carcinoma With Multiple Neck Metastases-Cases With More Than Ten Pathologically Positive Lymph Nodes in the Unilateral Side

  Yasuyuki Shibuya, Takumi Hasegawa, Masaya Akashi, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

  Apr. 2013, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(4) (4), 793 - 797, English

  [Refereed]

  Scientific journal


• Evaluation of masticatory function after maxillectomy using a colour-changing chewing gum

  Y. Shibuya, S. Ishida, M. Kobayashi, T. Hasegawa, K. Nibu, T. Komori

  Mar. 2013, JOURNAL OF ORAL REHABILITATION, 40(3) (3), 191 - 198, English

  [Refereed]

  Scientific journal


• The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy.

  Hasegawa T, Ri S, Umeda M, Komatsubara H, Kobayashi M, Shigeta T, Yoshitomi I, Ikeda H, Shibuya Y, Asahina I, Komori T

  2013, J Craniomaxillofac Surg., 41(7) (7), 558 - 563.

  Scientific journal


• 顎下腺原発脱分化型腺様嚢胞癌の1例

  李 進彰, 重田 崇至, 長谷川 巧実, 高田 直樹, 吉武 賢, Komori Takahide

  Dedifferentiated carcinoma is defined as the abrupt transformation of a low-grade, well-differentiated tumor into a tumor of high malignancy. Because the transformed cells are highly aggressive, recurrence and metastasis frequently occur.
  We report a case of dedifferentiated carcinoma in adenoid cystic carcinoma of the submandibular gland with multiple metastases to the cervical lymph nodes and distant metastasis to the ileum.
  A 73-year-old woman was referred to our hospital because of submandibular gland carcinoma with multiple lymph node metastases. In another clinic, adenocarcinoma was pathologically diagnosed on lymph node biopsy. A surgically resected specimen showed that the tumor was composed of both a cribriform pattern of conventional low-grade adenoid cystic carcinoma and a high-grade dedifferentiated carcinoma. The lesion was thus a dedifferentiated carcinoma. Lymph node metastases contained dedifferentiated components. One year and a half after the operation, the tumor metastasized to the small intestine (ileum) . The tumor in the ileum was also pathologically diagnosed as a high-grade dedifferentiated carcinoma.

  Japanese Society of Oral and Maxillofacial Surgeons, 2013, 日本口腔外科学会誌, 59(9) (9), 588 - 592, Japanese

  [Refereed]

  Scientific journal


• 下顎枝垂直骨切り術における骨性治癒形態の経時的観察

  Hasegawa Takumi, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  Aug. 2012, 日本顎変形症学会雑誌, 22(3号) (3号), 216 - 222, Japanese

  [Refereed]

  Scientific journal


• 口蓋に発生した嚢胞腺癌の1例

  Shibuya Yasuyuki, Hasegawa Takumi, Komori Takahide

  Jul. 2012, 日本口腔科学会雑誌, 61(3号) (3号), 316, Japanese

  [Refereed]

  Research society


• 下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経麻痺の経時的変化に関する検討

  Hasegawa Takumi, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  May 2012, 日本顎変形症学会雑誌, 22(2号) (2号), 107, Japanese

  [Refereed]

  Research society


• Mandibular Hematoma Cells as a Potential Reservoir for Osteoprogenitor Cells in Fractures

  Takumi Hasegawa, Masahiko Miwa, Yoshitada Sakai, Takahiro Nikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Masahiro Kurosaka, Takahide Komori

  Mar. 2012, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 70(3) (3), 599 - 607, English

  [Refereed]

  Scientific journal


• 外科処置を行ったBP製剤投与患者の臨床統計的観察

  長谷川 巧実, 李 進彰, 後藤 育子, 吉武 賢, 中野 沙織, 梅田 正博, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2012, 日本口腔科学会雑誌, 61(1) (1), 131 - 132, Japanese


• 抗血栓療法継続下で抜歯を施行した患者の出血性合併症に関する臨床的検討 ワルファリン投与患者282例について

  Shigeta Takashi, Umeda Masahiro, Shibuya Yasuyuki, Komori Takahide, Hasegawa Takumi

  (NPO)日本口腔科学会, Jan. 2012, 日本口腔科学会雑誌, 61(1号) (1号), 1 - 7, Japanese

  [Refereed]

  Scientific journal


• 抗凝固療法継続下で抜歯を施行した患者の出血性合併症に関する臨床的検討

  Shigeta Takashi, Umeda Masahiro, Shibuya Yasuyuki, Minamikawa Tsutomu, Hasegawa Takumi, Komori Takahide

  Jan. 2012, 日本口腔科学会雑誌, 61(1号) (1号), 150, Japanese

  [Refereed]

  Research society


• Analysis of the 619 Brånemark system TiUnite implants: A retrospective study

  Yasuyuki Shibuya, Naoki Takata, Junichiro Takeuchi, Kazuyuki Tsuji, Ishida Suguru, Masaki Kobayashi, Hiroaki Suzuki, Takumi Hasegawa, Isao Kamae, Takahide Komori

  2012, Kobe Journal of Medical Sciences, 58(1) (1), E19 - E28, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 下顎前歯部に発生した軟骨肉腫の1例

  長谷川 巧実, 梅田 正博, 吉武 賢, 高橋 英哲, 山田 周子, 古森 孝英

  (公社)日本口腔外科学会, Jun. 2011, 日本口腔外科学会雑誌, 57(6) (6), 355 - 359, Japanese


• Multivariate relationships among risk factors and hypoesthesia of the lower lip after extraction of the mandibular third molar

  Takumi Hasegawa, Shinshou Ri, Masahiro Umeda, Takahide Komori

  Jun. 2011, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 111(6) (6), E1 - E7, English

  [Refereed]

  Scientific journal


• Osseous healing after a sagittal splitting ramus osteotomy

  T. Hasegawa, C. Tateishi, R. Uchida, C. Nishi, S. Furudoi, Y. Shibuya, S. Yokoo, T. Komori

  May 2011, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 40(5) (5), 475 - 482, English

  Scientific journal


• The effect of transcutaneous application of carbon dioxide (CO2) on skeletal muscle

  Keisuke Oe, Takeshi Ueha, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Akihiro Koh, Takumi Hasegawa, Masaya Tanaka, Masahiko Miwa, Masahiro Kurosaka

  Apr. 2011, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 407(1) (1), 148 - 152, English

  [Refereed]

  Scientific journal


• 抗凝固薬継続下で歯科観血処置を行った228例の検討 後出血の頻度と対象について

  吉武 賢, 梅田 正博, 村田 真穂, 重田 崇至, 長谷川 巧実, 井堂 信二郎, 李 進彰, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2011, 日本口腔科学会雑誌, 60(1) (1), 60 - 60, Japanese


• 下顎智歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

  長谷川 巧実, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, 重田 崇至, 井堂 信二郎, 古森 孝英

  (NPO)日本口腔科学会, Jan. 2011, 日本口腔科学会雑誌, 60(1) (1), 84 - 85, Japanese


• 口腔外科手術時の開放創に対するネオベールシートおよびボルヒールスプレーの使用経験(第2報) 早期脱落の原因と対処法

  村田 真穂, 梅田 正博, 竹内 純一郎, 鈴木 泰明, 古森 孝英, 長谷川 巧実, 井堂 信二郎, 李 進彰

  (NPO)日本口腔科学会, Jan. 2011, 日本口腔科学会雑誌, 60(1) (1), 186 - 186, Japanese


• ミニシンポジウム/抗血栓療法 抗血栓療法継続下での歯科観血的処置後の出血の現状と対策

  重田 崇至, 李 進彰, 長谷川 巧実, 井堂 信二郎, 梅田 正博, 村田 真穂, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英

  (一社)日本有病者歯科医療学会, Dec. 2010, 有病者歯科医療, 19(3) (3), 197 - 198, Japanese


• A case of cervical necrotizing fasciitis complicated by acute lung failure due to sepsis after operation

  IDO Shinjiro, RI Shinshou, SHIGETA Takashi, HASEGAWA Takumi, ARIMA Hiromi, KOMORI Takahide

  The patient was a 63-year-old woman with a history of diabetes. At initial diagnosis, blood tests suggested the presence of severe infection because the while cell count was 20800/μland the C-reactive protein level was 35.6 mg/dl, but computed tomographic (CT) imaging showed no gas in the submandibular space. She received anti-inflammatory treatment after hospitalization, but the symptoms did not improve. We therefore repeated CT imaging and discovered gas in the tissue space around the submental region. Based on the diagnosis of cervical necrotizing fasciitis, we performed emergency surgery, curettage of the lesion, and open surgery. The preoperative plain chest X-ray films the showed no abnormal findings. On the following day after surgery, SpO₂ fell to the range of 80 %. A plain chest X-ray film showed shadows over the entire right lung field. The left lung showed signs of pneumonia with diffuse shadows. Chest CT images revealed shadows and accumulations of pleural effusion in both lung fields. The patient was given a diagnosis of a lung injury due to acute respiratory distress syndrome (ARDS) complicated by a severe infection. She received an intravenous drip infusion of sivelestat sodium (product name: Elaspol ^Ⓡ ) at a dose of 200 mg/day for 7 days. Pneumonia started to improve on the day afterstarting treatment.
  Our findings suggest that patients with severe infection should receive systemic management, bearing in mind potential complications of ARDS.

  Japanese Society of Oral and Maxillofacial Surgeons, Oct. 2010, Journal of Oral Surgery Society of Japan, 56(10) (10), 581 - 585, Japanese


• 下顎智歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

  長谷川 巧実, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, 重田 崇至, 井堂 信二郎, 古森 孝英

  (公社)日本口腔外科学会, Oct. 2010, 日本口腔外科学会雑誌, 56(10) (10), 568 - 576, Japanese


• NBI、ルゴール染色の併用により、早期に発見し得た舌表在癌の検討

  長谷川 巧実, 李 進彰, 井堂 信二郎, 重田 崇至, 吉武 賢, 中野 沙織, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2010, 日本口腔外科学会雑誌, 56(Suppl.) (Suppl.), 97 - 97, Japanese


• 抗血栓療法患者の歯科処置における止血困難症例の3症例

  李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 中野 沙織, 梅田 正博, 古森 孝英

  (一社)日本障害者歯科学会, Sep. 2010, 障害者歯科, 31(3) (3), 558 - 558, Japanese


• Efficient Cell-seeding into Scaffolds Improves Bone Formation

  T. Hasegawa, M. Miwa, Y. Sakai, T. Niikura, S. Y. Lee, K. Oe, T. Iwakura, M. Kurosaka, T. Komori

  Aug. 2010, JOURNAL OF DENTAL RESEARCH, 89(8) (8), 854 - 859, English

  [Refereed]

  Scientific journal


• Nondestructive Evaluation of Cell Numbers in Bone Marrow Stromal Cell/beta-Tricalcium Phosphate Composites Using Ultrasound

  Keisuke Oe, Masahiko Miwa, Kouki Nagamune, Yoshitada Sakai, Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Takumi Hasegawa, Nao Shibanuma, Yutaka Hata, Ryosuke Kuroda, Masahiro Kurosaka

  Jun. 2010, TISSUE ENGINEERING PART C-METHODS, 16(3) (3), 347 - 353, English

  [Refereed]

  Scientific journal


• 下顎前歯部歯槽骨に発生した軟骨肉腫の1例

  吉武 賢, 梅田 正博, 長谷川 巧実, 西 周子, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Mar. 2010, 日本口腔科学会雑誌, 59(2) (2), 99 - 99, Japanese


• 障害者(児)における全麻下治療の臨床統計的検討

  李 進彰, 井堂 信二郎, 重田 崇至, 長谷川 巧実, 有馬 宏美, 梅田 正博, 澁谷 恭之, 田中 武彦, 中神 正博, 麻柄 真也, 長谷川 雅一, 鎌田 真砂史, 古森 孝英

  (一社)日本障害者歯科学会, Sep. 2009, 障害者歯科, 30(3) (3), 221 - 221, Japanese


• Osteogenic activity of human fracture haematoma-derived progenitor cells is stimulated by low-intensity pulsed ultrasound in vitro

  T. Hasegawa, M. Miwa, Y. Sakai, T. Niikura, M. Kurosaka, T. Komori

  Feb. 2009, JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 91B(2) (2), 264 - 270, English

  [Refereed]

  Scientific journal


• Human hypertrophic nonunion tissue contains mesenchymal progenitor cells with multilineage capacity in vitro.

  Iwakura T, Miwa M, Sakai Y, Niikura T, Lee SY, Oe K, Hasegawa T, Kuroda R, Fujioka H, Doita M, Kurosaka M

  Hypertrophic nonunion usually results from insufficient fracture stabilization. Therefore, most hypertrophic nonunions simply require the stabilization of the nonunion site. However, the reasons why union occurs without treating the nonunion site directly is not well understood biologically. In this study, we hypothesized that the intervening tissue at the hypertrophic nonunion site (nonunion tissue) could serve as a reservoir of mesenchymal progenitor cells and investigated whether the cells derived from nonunion tissue had the capacity for multilineage mesenchymal differentiation. After nonunion tissue was obtained, it was cut into strips and cultured. Homogenous fibroblastic adherent cells were obtained. Flow cytometry revealed that the adherent cells were consistently positive for mesenchymal stem cell related markers CD13, CD29, CD44, CD90, CD105, CD166, and negative for the hematopoietic markers CD14, CD34, CD45, and CD133, similar to control bone marrow stromal cells. In the presence of lineage-specific induction factors, the adherent cells differentiated in vitro into osteogenic, chondrogenic, and adipogenic cells. These results demonstrated for the first time that hypertrophic nonunion tissue contains multilineage mesenchymal progenitor cells. This suggests that hypertrophic nonunion tissue plays an important role during the healing process of hypertrophic nonunion by serving as a reservoir of mesenchymal cells that are capable of transforming into cartilage and bone forming cells.

  Feb. 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27(2) (2), 208 - 215, English, International magazine

  [Refereed]

  Scientific journal


• Two cases of masticator space abscess initially diagnosed as temporomandibular joint disorder.

  Hasegawa T, Shibuya Y, Kuroki S, Takeuchi J, Yokoo S, Umeda M, Komori T

  2008, Kobe Journal of Medical Sciences, 54(3) (3), 163 - 168.


• 舌および頸部に発生し嚥下障害をきたした巨大な血管奇形の1例

  白坂 渉, 宗本 幸子, 志水 素子, 重田 崇至, 長谷川 巧実, 梅田 正博, 古森 孝英

  (公社)日本口腔外科学会, Dec. 2007, 日本口腔外科学会雑誌, 53(12) (12), 758 - 758, Japanese


• 当科における高度先進医療「インプラント義歯」の臨床統計的検討

  長谷川 巧実, 澁谷 恭之, 真砂 洋, 宗本 幸子, 村田 真穂

  (公社)日本口腔インプラント学会, Mar. 2007, 日本口腔インプラント学会誌, 20(1) (1), 139 - 140, Japanese


• 下顎骨転移性腫瘍の5例

  小松原 秀紀, 梅田 正博, 長谷川 巧実, 尾島 泰公, 南川 勉, 重田 崇至, 古森 孝英

  (公社)日本口腔外科学会, Sep. 2006, 日本口腔外科学会雑誌, 52(Suppl.) (Suppl.), 76 - 76, Japanese

• Is withdrawal of antiresorptive agents necessary before and after tooth extraction? A systematic review

  Daisuke Takeda, Hiroshi Kurita, Yoshihisa Kashima, Takumi Hasegawa, Masaaki Miyakoshi, Shin ichi Yamada, Yoshiko Yamamura, Sakiko Soutome

  Jan. 2024, Clinical Oral Investigations, 28(1) (1)

  Book review


• Neutrophil-to-lymphocyte ratio in response to nivolumab for oral squamous cell carcinoma: a retrospective cohort study

  立浪秀剛, 冨原圭, 山田慎一, 池田篤司, 今上修一, 中井裕美, 黒原一人, 吉岡幸男, 長谷川巧実, 鳴瀬智史, 新山宗, 嶋根哲, 上田倫弘, 柳本惣市, 明石昌也, 梅田正博, 栗田浩, 宮崎晃亘, 新井直也, 野口誠

  2023, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st


• Report of the Working Group on surgery (resection)

  柳本惣市, 山川延宏, 山田慎一, 長谷川巧実, 武田大介, 鈴木崇嗣, 松山たまも, 大林史誠, 山崎佐知子, 福谷多恵子, 青木隆幸

  2023, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st


• A study of patients who needed to apply for nursing insurance during hospitalization for oral cancer

  武田大介, 長谷川巧実, 筧康正, 明石昌也

  2022, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th


• A multicenter retrospective study of tongue cancer closed surgical margins-Japan Oral Oncology Group (JOOG) study-

  大鶴光信, 長谷川巧実, 明石昌也, 山川延宏, 桐田忠昭, 大倉正也, 大倉正也, 山田慎一, 栗田浩, 平井英治, 山本晃三, 猪俣徹, 里見貴史, 齋藤寛一, 野村武史, 古川浩平, 鳴瀬智史, 柳本惣市, 梅田正博

  2022, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th


• Pre-operative Head CT and Pathological Image Registration using Normalized Cross-Correlation and Dice Coefficient

  松岡志宜, 盛田健人, 武田大介, 長谷川巧実, 若林哲史

  2021, 電子情報通信学会技術研究報告(Web), 120(431(MI2020 47-97)) (431(MI2020 47-97))


• Automatic estimation of the extent of osteomyelitis of the jaw by anomaly detection

  星野秀晃, 盛田健人, 武田大介, 長谷川巧実, 若林哲史

  2021, 電子情報通信学会技術研究報告(Web), 120(431(MI2020 47-97)) (431(MI2020 47-97))


• Effect of percutaneous administration of carbon dioxide to improve tumor immunosuppression

  八谷奈苗, 長谷川巧実, 武田大介, 齊藤泉, 有本智美, 筧康正, 榊原晶子, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• A case of tongue cancer histopathologically diagnosed as lymphoepithelial carcinoma

  武田大介, 重岡学, 長谷川真子, 村上明希, 八谷奈苗, 長谷川巧実, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• Consideration of non-survival cases in patients with oral squamous cell carcinoma and Future perspectives in a tertiary referral center

  長谷川巧実, 武田大介, 筧康正, 明石昌也

  2021, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th


• 口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究

  後藤弘一, 山田慎一, 長谷川巧実, 吉村仁志, 五月女さき子, 冨原圭, 長谷川温, 菱田純代, 上田順宏, 傳田祐也, 岡本健二郎, 明石昌也, 近津大地, 野口誠, 太田嘉英, 藤田茂之, 藤田茂之, 渋谷恭之, 桐田忠昭, 梅田正博, 栗田浩

  2020, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th


• Effect of perioperative oral management on the prevention of surgical site infection after colorectal cancer surgery: A multicenter retrospective analysis

  延原浩, 五月女さき子, 林田咲, 梅田正博, 長谷川巧実, 明石昌也, 山田慎一, 栗田浩, 中原寛和, 上田順宏, 桐田忠昭, 中村知寿, 渋谷恭之, 山口泰平, 森和代

  2020, 日本外科感染症学会雑誌(Web), 17(5) (5)


• 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

  高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

  (一社)日本有病者歯科医療学会, Dec. 2019, 有病者歯科医療, 28(6) (6), 471 - 471, Japanese


• 「口腔がん治療における周術期口腔機能管理とは?」 口腔・中咽頭がん放射線治療時の口腔粘膜炎と口腔カンジダ症のリスク因子 多施設共同研究による326例の解析結果

  西井 美佳, 五月女 さき子, 長谷川 巧実, 柚鳥 宏和, 川北 晃子, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也, 古森 孝英

  (一社)日本口腔腫瘍学会, Sep. 2019, 日本口腔腫瘍学会誌, 31(3) (3), 111 - 116, Japanese


• 口腔・中咽頭がん放射線治療時の口腔粘膜炎予防法について 歯科衛生士の立場からの提言

  西井 美佳, 長谷川 巧実, 澤田 麻衣子, 巽口 明香, 岩田 英治, 五月女 さき子, 兒島 由佳, 船原 まどか, 梅田 正博, 古森 孝英

  (一社)日本口腔ケア学会, Apr. 2019, 日本口腔ケア学会雑誌, 13(3) (3), 189 - 189, Japanese


• 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

  高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

  (一社)日本歯科薬物療法学会, Mar. 2019, 歯科薬物療法, 38(2) (2), 176 - 176, Japanese


• 抗凝固薬内服患者における下顎智歯抜去後の後出血発症に関する多施設共同後ろ向き観察研究

  高田 亮, 山田 慎一, 長谷川 巧実, 五月女 さき子, 吉村 仁志, 宮腰 昌明, 上田 順宏, 岡本 健二朗, 菱田 純代, 横関 麻里, 中原 寛和, 藤田 茂之, 古森 孝英, 佐野 和生, 北川 善政, 渋谷 恭之, 桐田 忠昭, 梅田 正博, 栗田 浩

  (一社)日本歯科薬物療法学会, Mar. 2019, 歯科薬物療法, 38(2) (2), 176 - 176, Japanese


• 口腔扁平上皮癌における人工多能性幹細胞関連因子の発現について

  武田大介, 長谷川巧実, 江崎友美, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th


• 口腔扁平上皮癌を有する高齢者に対するG8スクリーニングツールの臨床的意義

  箱山友祐, 箱山友祐, 山田慎一, 横関麻里, 田中宏和, 田中宏和, 長谷川巧実, 奥山紘平, 山川延宏, 大倉正也, 柳本惣市, 古森孝英, 桐田忠昭, 梅田正博, 栗田浩

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th


• 当科におけるメトトレキサート関連リンパ増殖性疾患の3例

  大橋雄高, 筧康正, 松田彩, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 148, Japanese


• 当科におけるUnusualな再発症例について

  筧康正, 南川勉, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, Japanese


• 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

  長谷川巧実, 武田大介, 齋藤泉, 岩田英治, 筧康正, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, Japanese


• 再建を伴う口腔癌の周術期静脈血栓塞栓症について

  筧康正, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, Japanese


• 口腔癌におけるPET‐MRI~第二報~

  瓜生開人, 南川勉, 大橋雄高, 大橋雄高, 松田彩, 武田大介, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2019, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, Japanese


• 「抗血栓療法患者の抜歯ガイドライン」改訂に向けて2015年度版の自己評価 抗凝固療法(ワルファリン投与)患者の抜歯後出血リスク因子について 多施設共同研究の結果から

  長谷川 巧実

  (一社)日本有病者歯科医療学会, Dec. 2018, 有病者歯科医療, 27(6) (6), 451 - 451, Japanese


• A literature review of perioperative antibiotic administration in surgery for medication-related osteonecrosis of the jaw.

  Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

  PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.

  Dec. 2018, Oral and maxillofacial surgery, 22(4) (4), 369 - 378, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究

  長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2018, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, Japanese


• 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

  山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 廣瀬 満理奈, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

  (一社)日本癌治療学会, Oct. 2018, 日本癌治療学会学術集会抄録集, 56回, P1 - 1, English


• 医科歯科連携 がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究

  五月女 さき子, 林田 咲, 川北 晃子, 岩田 英治, 長谷川 巧実, 古森 孝英, 山田 慎一, 栗田 浩, 宮本 大模, 渋谷 恭之, 河岡 有美, 兒島 由佳, 山口 泰平, 於保 孝彦, 中原 寛和, 延原 浩, 船原 まどか, 梅田 正博

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 89 - 89, Japanese


• 薬剤関連顎骨壊死の治療と予防(口腔外科の立場から)

  梅田正博, 林田咲, 長谷川巧実, 五月女さき子

  (一社)日本骨代謝学会, Jul. 2018, 日本骨代謝学会学術集会プログラム抄録集, 36回, 107 - 107, Japanese


• 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

  大橋 雄高, 筧 康正, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 110 - 110, Japanese


• 医科歯科連携 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 注射BP製剤とデノスマブにおける抜歯前休薬の有無について

  長谷川 巧実, 上田 順宏, 近藤 英司, 岩田 英治, 林田 咲, 河岡 有美, 小林 正樹, 宮本 大模, 武田 侑也, 中原 寛和, 橘 進彰, 兒島 由佳, 五月女 さき子, 桐田 忠昭, 栗田 浩, 渋谷 恭之, 藤田 茂之, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 89 - 89, Japanese


• 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

  筧 康正, 南川 勉, 白井 達也, 大橋 雄高, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 103 - 103, Japanese


• 当科における口腔癌への緩和照射に関する臨床的検討

  松田 彩, 南川 勉, 白井 達也, 筧 康正, 松井 太輝, 長谷川 巧実, 榊原 晶子, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 112 - 112, Japanese


• 術後に気道閉塞を生じた口腔癌患者の3例

  香西 慎一, 松井 太輝, 筧 康正, 松田 彩, 明石 昌也, 長谷川 巧実, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 113 - 113, Japanese


• 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

  八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 松井 太輝, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 117 - 117, Japanese


• 口腔癌原発巣手術における術中迅速診断の臨床的検討

  白井 達也, 松井 太輝, 筧 康正, 大橋 雄高, 松田 彩, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 119 - 119, Japanese


• 膠原病を有する口腔癌症例の臨床的検討

  廣田 純也, 南川 勉, 松田 彩, 松井 太輝, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 121 - 121, Japanese


• 下顎智歯抜歯後の術後出血に関するリスク因子についての検討

  廣田 純也, 長谷川 巧実, 西條 翔, 大山 剛平, 武田 大介, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 131 - 132, Japanese


• がん治療中の口腔有害事象発症リスクに関する後ろ向き観察研究

  三谷 泉, 長谷川 巧実, 難波 渚, 西井 美佳, 明石 昌也, 古土井 春吾, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2018, 日本口腔科学会雑誌, 67(2) (2), 171 - 172, Japanese


• 高齢者疾患と歯科治療 注意すべき薬とその対応法

  長谷川 巧実

  (一社)兵庫県歯科医師会, May 2018, 歯界月報, (802) (802), 84 - 84, Japanese


• 金属アレルギーを伴う骨格性下顎前突患者に対し外科的矯正治療を行った1例

  塩屋園 敦, 立石 千鶴, 長谷川 巧実, 木本 明, 鈴木 泰明, 古土井 春吾, 古森 孝英, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班

  (NPO)日本顎変形症学会, May 2018, 日本顎変形症学会雑誌, 28(2) (2), 181 - 181, Japanese


• がん口腔管理ガイドライン 癌患者の口腔機能管理の基準に関する多施設共同後ろ向き観察研究

  山田 慎一, 五月女 さき子, 長谷川 巧実, 東條 格, 中原 寛和, 河上 真緒, 宮本 大模, 藤田 茂之, 古森 孝英, 桐田 忠昭, 渋谷 恭之, 梅田 正博, 栗田 浩

  (一社)日本口腔ケア学会, Apr. 2018, 日本口腔ケア学会雑誌, 12(3) (3), 134 - 134, Japanese


• 肺癌術後肺炎予防における周術期口腔機能管理の有用性 傾向スコアマッチング法を用いた解析

  岩田 英治, 長谷川 巧実, 山田 慎一, 川下 由美子, 吉松 昌子, 宮本 大模, 中原 寛和, 渋谷 恭之, 栗田 浩, 古森 孝英

  (一社)日本口腔ケア学会, Apr. 2018, 日本口腔ケア学会雑誌, 12(3) (3), 196 - 196, Japanese


• 抜歯における下唇知覚鈍麻と上顎洞穿孔のリスクとその対応

  Hasegawa Takumi

  (一社)兵庫県歯科医師会, Apr. 2018, 歯界月報, (801) (801), 52 - 60, Japanese

  Introduction scientific journal


• 下顎智歯抜歯後の術後出血に関するリスク因子についての検討

  廣田純也, 長谷川巧実, 西條翔, 大山剛平, 武田大介, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2)


• がん手術時の周術期口腔機能管理の有効性に関する多施設共同研究

  五月女さき子, 林田咲, 川北晃子, 岩田英治, 長谷川巧実, 古森孝英, 山田慎一, 栗田浩, 宮本大模, 渋谷恭之, 河岡有美, 兒島由佳, 山口泰平, 於保孝彦, 中原寛和, 延原浩, 船原まどか, 梅田正博

  2018, 日本口腔科学会雑誌(Web), 67(2) (2)


• 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究~注射BP製剤とデノスマブにおける抜歯前休薬の有無について~

  長谷川巧実, 上田順宏, 近藤英司, 岩田英治, 岩田英治, 林田咲, 河岡有美, 小林正樹, 宮本大模, 武田侑也, 中原寛和, 橘進彰, 兒島由佳, 五月女さき子, 桐田忠昭, 栗田浩, 渋谷恭之, 藤田茂之, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2)


• 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討

  八谷奈苗, 長谷川巧実, 武田大介, 筧康正, 松井太輝, 明石昌也, 南川勉, 古土井春吾, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 117(J‐STAGE), Japanese


• 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討

  筧康正, 南川勉, 白井達也, 大橋雄高, 大橋雄高, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 103(J‐STAGE), Japanese


• 膠原病を有する口腔癌症例の臨床的検討

  廣田純也, 南川勉, 松田彩, 松井太輝, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 121(J‐STAGE), Japanese


• 放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性

  鰐渕聡, 明石昌也, 平岡佑二郎, 武田大介, 筧康正, 松井太輝, 長谷川巧実, 南川勉, 古土井春吾, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, Japanese


• 皮弁再建後の再発舌癌に対して救済手術を施行した2例

  大橋雄高, 松井太輝, 筧康正, 正井友里子, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, Japanese


• 当科における口腔癌への緩和照射に関する臨床的検討

  松田彩, 南川勉, 白井達也, 筧康正, 松井太輝, 長谷川巧実, 榊原晶子, 明石昌也, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 112(J‐STAGE), Japanese


• 超音波断層法による口腔癌頸部リンパ節転移の検討

  筧康正, 南川勉, 正井友里子, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 重田崇至, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, Japanese


• 舌扁平上皮癌の原発巣再発例の検討

  松井太輝, 南川勉, 大橋雄高, 正井友里子, 松田彩, 筧康正, 長谷川巧実, 明石昌也, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, Japanese


• 術後に気道閉塞を生じた口腔癌患者の3例

  香西慎一, 松井太輝, 筧康正, 松田彩, 明石昌也, 長谷川巧実, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 113(J‐STAGE), Japanese


• 口腔癌術後病理minor risk症例の臨床的検討

  松田彩, 松井太輝, 正井友里子, 筧康正, 長谷川巧実, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, Japanese


• 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討

  大橋雄高, 筧康正, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 110(J‐STAGE), Japanese


• 口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー

  明石昌也, 筧康正, 武田大介, 松井太輝, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

  2018, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, Japanese


• 口腔癌原発巣手術における術中迅速診断の臨床的検討

  白井達也, 松井太輝, 筧康正, 大橋雄高, 大橋雄高, 松田彩, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2018, 日本口腔科学会雑誌(Web), 67(2) (2), 119(J‐STAGE), Japanese


• 口腔がん手術の適応を考える 頸部リンパ節の状態から考えた手術の適応と補助療法

  Hasegawa Takumi, 南川勉, 古森孝英

  (一社)日本口腔腫瘍学会, Dec. 2017, 日本口腔腫瘍学会誌, 29(4) (4), 198 - 205, Japanese

  Introduction scientific journal


• 移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例

  山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 松本 耕佑, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2017, Japanese Journal of Maxillo Facial Implants, 16(3) (3), 233 - 233, Japanese


• 口腔ケアの食道癌術後肺炎予防効果に関する多施設共同研究:傾向スコア法による解析

  五月女さき子, 柳本惣市, 山田慎一, 栗田浩, 山内千佳, 渋谷恭之, 中原寛和, 長谷川巧実, 古森孝英, 兒島由佳, 青木久美子, 桐田忠昭, 於保孝彦, 梅田正博

  (一社)日本癌治療学会, Oct. 2017, 日本癌治療学会学術集会(Web), 55th, ROMBUNNO.PS‐2 (WEB ONLY) - 2, Japanese


• 当科における予防的頸部郭清術に関する後ろ向き検討

  松田 彩, 筧 康正, 正井 友里子, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 113 - 113, Japanese


• 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

  正井 友里子, 南川 勉, 松田 彩, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, Japanese


• 口腔癌手術における嚥下改善手術に関する臨床的検討

  筧 康正, 南川 勉, 正井 友里子, 松田 彩, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2017, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, Japanese


• 食道がん術後肺炎に対する口腔ケアの予防効果~口腔ケア学会共同研究委員会による多施設共同研究の提案~

  五月女さき子, 栗田浩, 植野高章, 渋谷恭之, 大部一成, 山口泰平, 長谷川巧実, 冨原圭, 青木久美子, 池上由美子

  (一社)日本口腔ケア学会, 22 Apr. 2017, 日本口腔ケア学会雑誌, 11(3) (3), 122 - 122, Japanese


• 頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析

  西井 美佳, 筧 康正, 難波 渚, 澤田 麻衣子, 岩田 英治, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英

  (一社)日本口腔ケア学会, Apr. 2017, 日本口腔ケア学会雑誌, 11(3) (3), 121 - 121, Japanese


• 肺癌術後肺合併症と周術期口腔機能管理の有用性

  岩田 英治, 長谷川 巧実, 西井 美佳, 明石 昌也, 古森 孝英

  (一社)日本口腔ケア学会, Apr. 2017, 日本口腔ケア学会雑誌, 11(3) (3), 170 - 170, Japanese


• 口腔癌放射線治療における新規併用療法の開発

  岩田英治, 長谷川巧実, 武田大介, 斎藤泉, 有本智美, 明石昌也, 南川勉, 古森孝英

  2017, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 35th


• 当科における予防的頸部郭清術に関する後ろ向き検討

  松田彩, 筧康正, 正井友里子, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, Japanese


• 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討

  正井友里子, 南川勉, 松田彩, 米澤奈津季, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, Japanese


• 口腔癌手術における嚥下改善手術に関する臨床的検討

  筧康正, 南川勉, 正井友里子, 松田彩, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2017, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, Japanese


• Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.

  Takumi Hasegawa, Akira Tachibana, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Takahide Komori

  PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.

  Dec. 2016, Oral and maxillofacial surgery, 20(4) (4), 369 - 375, English, International magazine


• 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

  山下淳也, 山下淳也, 鈴木泰明, 筧康正, 木本明, 長谷川巧実, 明石昌也, 古森孝英

  (公社)日本顎顔面インプラント学会, Nov. 2016, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 207 - 207, Japanese


• 当科におけるFibro-osseous lesionsの臨床的検討

  松尾 健司, 明石 昌也, 筧 康正, 松本 耕祐, 長谷川 巧実, 南川 勉, 古土井 春吾, 橘 進彰, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 127 - 128, Japanese


• 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

  筧 康正, 明石 昌也, 木本 明, 長谷川 巧実, 南川 勉, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 214 - 214, Japanese


• T1-2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究(JOOG RA1403)

  大鶴 光信, 太田 嘉英, 梅田 正博, 柳本 惣市, 栗田 浩, 鎌田 孝広, 桐田 忠昭, 山川 延宏, 上田 倫弘, 山下 徹郎, 大倉 正也, 相川 友直, 大廣 洋一, 栗林 和代, 山下 善弘, 長井 健太郎, 野口 一馬, 岸本 裕充, 長谷川 巧実, 古森 孝英, 傳田 祐也, 内藤 博之, 柴原 孝彦, 野口 忠秀, 唐木田 一成

  (一社)日本頭頸部癌学会, May 2016, 頭頸部癌, 42(2) (2), 170 - 170, Japanese


• 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

  榊原晶子, 榊原俊介, 楠元順哉, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th


• 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性 -多施設共同後ろ向き研究による検証-

  五月女さき子, 五月女さき子, 船原まどか, 船原まどか, 於保孝彦, 山田慎一, 山田慎一, 栗田浩, 栗田浩, 山内千佳, 山内千佳, 渋谷恭之, 渋谷恭之, 兒島由佳, 兒島由佳, 長谷川巧実, 長谷川巧実, 古森孝英, 古森孝英, 梅田正博, 梅田正博

  2016, 日本口腔科学会雑誌(Web), 65(4) (4)


• 食道がん術後肺炎予防に対する周術期口腔機能管理の有効性に関する多施設共同後ろ向き研究

  五月女さき子, 柳本惣市, 梅田正博, 長谷川巧実, 古森孝英, 山田慎一, 栗田浩, 渋谷恭之, 山内千佳, 兒島由佳

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 163, Japanese


• 当科におけるFibro‐osseous lesionsの臨床的検討

  松尾健司, 明石昌也, 筧康正, 松本耕祐, 長谷川巧実, 南川勉, 古土井春吾, 橘進彰, 古森孝英

  2016, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, Japanese


• 術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

  米澤奈津季, 南川勉, 北島一宏, 高橋佑輔, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, Japanese


• 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

  筧康正, 南川勉, 寺岡駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, Japanese


• 口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響

  定兼啓倫, 長谷川巧実, 渋谷恭之, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 明石昌也, 南川勉, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, Japanese


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, Japanese


• 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例

  筧康正, 明石昌也, 木本明, 長谷川巧実, 南川勉, 古森孝英

  2016, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, Japanese


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性

  明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英

  2016, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, Japanese


• 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

  武田大介, 長谷川巧実, 今井佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd


• 口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の進展度分類

  OTANI SHOHEI, YAMADA SHIN'ICHI, YANAMOTO SOICHI, HASEGAWA TAKUMI, MIYAKOSHI MASAAKI, OGA NORITAKA, KAMATA TAKAHIRO, KOMORI TAKAHIDE, KITAGAWA YOSHIMASA, KURITA HIROSHI, ASAHINA IZUMI, UMEDA MASAHIRO

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 245, Japanese


• 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

  齊藤泉, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, Japanese


• 当科における放射線性顎骨壊死に関する臨床的検討

  鰐渕聡, 明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, Japanese


• 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

  棚倉万紀子, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, Japanese


• 口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討

  米澤奈津季, 南川勉, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英

  2015, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, Japanese


• 【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項

  Komori Takahide, Akashi Masaya, Suzuki Yasuaki, 榊原晶子, Kimoto Akira, Minamikawa Tsutomu, Hasegawa Takumi, Furudoi Shungo

  (株)第一歯科出版, Jan. 2015, 歯科医療, 29(1号) (1号), 4 - 10, Japanese

  [Invited]

  Introduction scientific journal


• 【全身疾患と抜歯-最新の知識による適切な対応-】 抗凝固薬・抗血小板薬投与患者の抜歯

  Hasegawa Takumi, Komori Takahide

  Jan. 2015, 歯科医療, 29(1号) (1号), 45 - 52, Japanese

  [Invited]

  Introduction commerce magazine


• 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討

  筧康正, 南川勉, 高橋佑輔, 松井太輝, 長谷川巧実, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英

  2014, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, Japanese


• 40歳未満に発生した舌扁平上皮癌21例の検討

  高橋佑輔, 南川勉, 長谷川巧実, 米澤奈津季, 筧康正, 松井太輝, 榊原晶子, 重田崇至, 渋谷恭之, 古森孝英

  2014, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 219, Japanese


• ビスホスホネート関連顎骨壊死(BRONJ)に対する新規治療法の開発

  Komori Takahide, Hasegawa Takumi

  2013, 大和証券ヘルス財団研究業績集, 36, 104 - 107, Japanese

  Introduction other


• 口腔外科手術の開放創におけるポリグリコール酸シート(ネオベール)およびフィブリン糊スプレー(ボルヒール)の使用経験

  村田 真穂, 梅田 正博, 竹内 純一郎, 鈴木 泰明, 渋谷 恭之, 重田 崇至, 長谷川 巧実, 李 進彰, 小林 正樹, 古森 孝英

  (NPO)日本口腔科学会, Jul. 2011, 日本口腔科学会雑誌, 60(3) (3), 232 - 239, Japanese


• 骨折血腫細胞の多分化能についての検討と低出力超音波パルス(LIPUS)による効果について

  長谷川 巧実, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 康 暁博, 澁谷 恭之, 黒坂 昌弘, 古森 孝英

  (公社)日本顎顔面インプラント学会, Nov. 2008, Japanese Journal of Maxillo Facial Implants, 7(2) (2), 171 - 171, Japanese


• ヒト新鮮骨折において、低出力超音波パルス(LIPUS)は骨折血腫細胞の骨分化を促進する

  岩倉 崇, 長谷川 巧実, 三輪 雅彦, 新倉 隆宏, 酒井 良忠, 大江 啓介, 李 相亮, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2008, 日本整形外科学会雑誌, 82(8) (8), S1195 - S1195, Japanese


• ヒトの骨折治癒過程に携わる骨折血腫細胞には骨形成蛋白が発現している

  新倉 隆宏, 三輪 雅彦, 酒井 良忠, 大江 啓介, 岩倉 崇, 長谷川 巧実, 黒坂 昌弘

  (公社)日本整形外科学会, Aug. 2008, 日本整形外科学会雑誌, 82(8) (8), S1259 - S1259, Japanese


• β-リン酸三カルシウム(β-TCP)内への骨髄幹細胞(BMSC)導入方法と骨形成能の検討

  長谷川 巧実, 澁谷 恭之, 三輪 雅彦, 酒井 良忠, 新倉 隆宏, 大江 啓介, 岩倉 崇, 黒坂 昌弘, 古森 孝英

  (公社)日本口腔インプラント学会, Mar. 2008, 日本口腔インプラント学会誌, 21(1) (1), 199 - 199, Japanese


• Nondestructive evaluation of cell numbers in bone marrow stromal cells biodegradable scaffold composites using ultrasound.

  K. Oe, M. Miwa, K. Nagamune, Y. Sakai, R. Kuroda, T. Hasegawa, T. Iwakura, N. Shibanuma, Y. Hata, M. Kurosaka

  Sep. 2007, JOURNAL OF BONE AND MINERAL RESEARCH, 22, S242 - S242, English

  Summary international conference

• 周術期等口腔機能管理の実際がよくわかる本．人工関節手術と口腔管理．

  長谷川巧実

  クインテッセンス株式会社．, 2020


• 日常の口腔外科 改訂版 スマートな病診連携のために / 5画像検査の読影

  Hasegawa Takumi, 藤岡学, 古森孝英

  Others, 永末書店, 2018, Japanese

  Scholarly book


• Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy

  AkashiM, Komori Takahide, MinamikawaT, Hasegawa Takumi, NishiiM, HashikawaK, SeddikMH, SasakiR

  Others, Oxford University Press, 2018, English

  Scholarly book


• Clinical Questionでわかるエビデンスに基づいた周術期口腔機能管理 / CHAPTER-4 周術期口腔機能管理に関するClinical Question Q16 骨吸収抑制薬投与患者の抜歯時に休薬は必要でしょうか?

  Hasegawa Takumi

  Others, 医歯薬出版, 2018, Japanese

  Scholarly book


• 全身疾患を有する患者の抜歯の際に注意すべき基本的事項 / 【全身疾患と抜歯-最新の知識による適切な対応-】

  古森孝英, 明石昌也, 鈴木泰明, 榊原晶子, 木本明, 南川勉, Hasegawa Takumi, 古土井春吾

  Others, 歯科医療, Jan. 2015, Japanese

  Scholarly book


• 抗凝固薬・抗血小板薬投与患者の抜歯 / 【全身疾患と抜歯-最新の知識による適切な対応-】

  Hasegawa Takumi, 古森孝英

  Others, －, Jan. 2015, Japanese

  Scholarly book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 抗血小板薬服用患者への対応

  Hasegawa Takumi, 浅井雅敏, 白神翔, 梅田正博

  Others, 第一歯科出版, 2014, Japanese

  General book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 抗凝固薬服用患者への対応

  Hasegawa Takumi, 黄文蘇, 井川恵理, 梅田正博

  Others, 第一歯科出版, 2014, Japanese

  General book


• 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 血小板減少患者への対応

  Hasegawa Takumi, 竹内佑香, 梅田正博

  Others, 第一歯科出版, 2014, Japanese

  General book

• The observational study of the risk factors associate with implant failure in our institution.

  Hasegawa T, Takeda D, Arimoto S, Kakei Y, Kimoto A, Akashi M

  The 4th Asia Pacific Region Congress of the International Association for Dental Research, Nov. 2019


• A multi-center retrospective study of mandibular fractures: Do occlusal support and the mandibular third molar affect mandibular condylar fractures?

  Takumi Hasegawa, Daisuke Takeda, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takahide Komori

  6th Asian Academy congress for TMJ, Jun. 2019


• A retrospective study of risk factors associated with distant metastasis in patients with oral squamous cell carcinoma

  Takumi Hasegawa, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori

  6th Asian Society of Head & Neck Oncology, Mar. 2019


• 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果

  長谷川巧実、武田大介、斉藤 泉、岩田英治、筧康正、榊原晶子、明石昌也、南川勉、古森孝英

  第37回日本口腔腫瘍学会総会, Jan. 2019

  [Invited]


• 口腔癌頸部リンパ節転移の様相と術後補助療法に関する多施設共同研究

  長谷川巧実、柳本惣市、大鶴光信、大倉正也、山川延宏、山田慎一、古森孝英

  第37回日本口腔腫瘍学会総会, Jan. 2019

  [Invited]


• 抜歯と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究 ～注射BP製剤とデノスマブにおける抜歯前休薬の有無について～

  長谷川巧実、上田順宏、近藤英司岩田英治林田 咲、河岡有美、小林正樹、宮本大模、武田侑也、中原寛和、橘 進彰、兒島由佳、五月女さき子、桐田忠昭、栗田 浩、渋谷恭之、藤田茂之、古森孝英

  第72回日本口腔科学会学術集会, May 2018


• 下顎智歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

  長谷川巧実、明石昌也、橘 進彰、古土井春吾、古森孝英

  第22回口腔顔面神経機能大会, Mar. 2018


• 下顎骨壊死における下歯槽神経障害の臨床病理学的検討

  平岡佑二郎, AKASHI MASAYA, SHIGEOKA MANABU, 楠元順哉, HASEGAWA TAKUMI, KOMORI TAKAHIDE

  第62回日本口腔外科学会総会・学術大会, Oct. 2017, Japanese, 京都, Domestic conference

  Oral presentation


• 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究．

  Akashi Masaya, 楠元順哉, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第41回日本頭頸部癌学会（京都）, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conference

  Oral presentation


• 4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION．

  Akashi Masaya, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Hasegawa Takumi, Noriyuki Negi, Hashikawa Kazunobu, Yasuyuki Shibuya, Takahashi Satoru, Komori Takahide

  23nd International Conference on Oral and Maxillofacial Surgery（Hong Kong）, Mar. 2017, Japanese, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, Domestic conference

  Oral presentation


• 口腔扁平上皮癌では外的刺激受容体（TRPVチャネル）の発現が亢進する．

  Sakakibara Akiko, 榊原俊介, 楠元順哉, 武田大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第35回口腔腫瘍学会（福岡）, Jan. 2017, Japanese, 口腔腫瘍学会, 福岡, Domestic conference

  Oral presentation


• 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例

  山下淳也, Suzuki Yasuaki, 筧康正, 木本 明, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第20回日本顎顔面インプラント学会, Dec. 2016, Japanese, 日本顎顔面インプラント学会, 東京, Domestic conference

  Poster presentation


• 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討

  片岡侑嗣, Hasegawa Takumi, 綿越健太, 浅井雅敏, 有本智美, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第20回日本顎顔面インプラント学会, Dec. 2016, Japanese, 日本顎顔面インプラント学会, 東京, Domestic conference

  Poster presentation


• 腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較

  平岡佑二郎, Akashi Masaya, 筧 康正, 楠元順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 放射線性顎骨壊死発症リスク因子の検討ー多施設共同後ろ向き研究ー

  兒島由佳, 柳本惣市, Hasegawa Takumi, Komori Takahide, 上田順宏, 桐田忠昭, 渋谷恭之, 山田慎一, 栗田浩, 梅田正博

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当科における舌癌・口底癌手術症例の再建方法に関する検討

  綿越健太, Minamikawa Tsutomu, 米澤奈津季, 筧 康正, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討

  難波 渚, Akashi Masaya, 西井美佳, 楠元順哉, Matsumoto Kousuke, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当科における口腔癌患者の口腔内細菌数の変化とSSIについて

  小守紗也華, Hasegawa Takumi, 西井美佳, Akashi Masaya, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討

  Sakakibara Akiko, 楠元 順哉, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第61回公益社団法人日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, Domestic conference

  Oral presentation


• 舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討

  Sakakibara Akiko, 楠元順哉, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 上顎洞隔壁の形態に関する解剖学的検討

  武田大介, Hasegawa Takumi, 有本智美, 小松原秀紀, Suzuki Yasuaki, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 口腔癌放射線治療における有効な新規併用療法の探索

  岩田英治, Hasegawa Takumi, 武田大介, 斉藤 泉, 有本智美, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 口腔癌術後リンパ浮腫に関するCT解析

  寺岡 駿, Akashi Masaya, 筧 康正, 楠元順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔外科手術と薬剤関連性顎骨壊死に関する多施設共同後ろ向き研究

  船原隆一郎, Hasegawa Takumi, 川北晃子, 上田順宏, 橘 進彰, 小林正樹, 児島由佳, 小松原秀紀, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤 泉, Hasegawa Takumi, 武田大介, 岩田英治, 有本智美, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本智美, Hasegawa Takumi, 齊藤 泉, 岩田英治, 武田大介, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究

  Hasegawa Takumi, Minamikawa Tsutomu, 米澤奈津季, 高橋佑輔, 筧 康正, Sakakibara Akiko, Akashi Masaya, Komori Takahide

  第61回日本口腔外科学会総会・学術大会, Nov. 2016, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• シンポジウム1:「抜くべきか 抜かざるべきか それが問題だ」骨吸収抑制剤患者における抜歯前休薬と術中処置について

  Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第12回日本口腔ケア協会学術大会, Nov. 2016, Japanese, 日本口腔ケア協会, 長崎, Domestic conference

  Oral presentation


• Development of the new treatment of OSCC by local application of transcutaneous carbon dioxide

  Iwata E, Hasegawa Takumi, Takeda D, Saito Izumi, Arimoto S, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

  Akashi Masaya, Hashikawa Kazunobu, Satoshi Wanifuchi, Megumi Kishimoto, Eiji Iwata, Yasumasa Kakei, Junya Kusumoto, Matsumoto Kousuke, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  The 23th Congress of EACMFS, Sep. 2016, English, Congress of EACMFS, London, イギリス, International conference

  Oral presentation


• Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw

  Akashi Masaya, Hashikawa Kazunobu, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto Kensuke, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomas

  Kakei Y, Akashi Masaya, Teraoka S, Hasegawa Takumi, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• A clinical study of injured patients treated with dental implants

  Suzuki Yasuaki, Takeuchi J, Matsuo K, Kakei Y, Kimoto A, Hasegawa Takumi, Akashi Masaya, Chikazu D, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• A clinical study of 12 implants resulting in implant removal

  Takahashi D, Suzuki Yasuaki, Kakei Y, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, Sep. 2016, Japanese, UKレーザー歯学会, London, UK, International conference

  Poster presentation


• 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題

  難波 渚, Akashi Masaya, 冨田 和, 田村恵利, 澤田麻衣子, 西井美佳, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第32回兵庫県歯科医学大会, Jul. 2016, Japanese, 兵庫県歯科医師会, 神戸, Domestic conference

  Oral presentation


• 上顎智歯抜歯のおける上顎洞穿孔リスクとその対応について

  Hasegawa Takumi, 橘 進彰, Komori Takahide

  第32回兵庫県歯科医学大会, Jul. 2016, Japanese, 兵庫県歯科医師会, 神戸, Domestic conference

  Oral presentation


• 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例

  中西洋介, Matsumoto Kousuke, 小守紗也華, Hasegawa Takumi, Akashi Masaya, 柚鳥宏和, 橘進彰, Komori Takahide

  第16回日本外傷歯学会総会・学術大会, Jul. 2016, Japanese, 日本外傷歯学会, 神戸, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  Akashi Masaya, Hashikawa Kazunobu, 鰐渕 聡, 楠元順哉, Hasegawa Takumi, Minamikawa Tsutomu, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価

  Akashi Masaya, Hashikawa Kazunobu, 鰐渕聡, 楠元 順哉, Hasegawa Takumi, Minamikawa Tsutomu, Terashi Hiroto, Komori Takahide

  第40回日本頭頸部癌学会, Jun. 2016, Japanese, 日本頭頸部癌学会, さいたま市, Domestic conference

  Oral presentation


• 口腔癌病理学的再発高リスク例に対する術後補助療法の検討

  Hasegawa Takumi, 大鶴光信, 柳本惣市, Minamikawa Tsutomu, 太田嘉英, 梅田正博, Komori Takahide

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 下顎歯肉がんのT分類（多施設共同後ろ向き研究 JOOG RA-1401）

  大倉正也, 伊藤 章, 太田嘉英, 大鶴光信, 梅田正博, 柳本惣市, 桐田忠昭, 山川延宏, Hasegawa Takumi, Komori Takahide, 栗田 浩, 鎌田孝広, 上田倫弘

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果

  有本智美, Hasegawa Takumi, 岡本奈那, 塩屋園敦, 立石千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第26回日本顎変形症学会総会・学術大会, Jun. 2016, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Poster presentation


• 下顎骨偏位と乳様突起体積および頭位に関する検討

  塩屋園敦, 立石千鶴, 浅井雅敏, 有本智美, 岡本奈那, Hasegawa Takumi, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第26回日本顎変形症学会総会・学術大会, Jun. 2016, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Poster presentation


• T2N0M0舌癌に予防郭清を行うことの是非に関する多施設共同研究（JOOG RA1403）

  大鶴光信, 太田嘉英, 梅田正博, 柳本惣市, 栗田 浩, 鎌田孝広, 桐田忠昭, 山川延宏, 上田倫弘, 山下徹郎, 大倉正也, 相川友直, 大廣洋一, 栗林和代, 山下善弘, 長井健太郎, 野口一馬, 岸本裕充, Hasegawa Takumi, Komori Takahide, 傳田祐也, 内藤博之, 柴原孝彦, 野口忠秀, 唐木田一成

  第40回日本頭頸部癌学会総会・学術大会, Jun. 2016, Japanese, 日本頭頸部癌学会, 埼玉, Domestic conference

  Oral presentation


• 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状

  平岡佑二郎, Akashi Masaya, Matsumoto Kousuke, Sakakibara Akiko, 木本 明, Hasegawa Takumi, Suzuki Yasuaki, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 当科におけるFibro-osseous lesionsの臨床的検討

  松尾健司, Akashi Masaya, 筧 康正, Matsumoto Kousuke, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 橘進彰, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 遺伝子解析により確定診断を得たMALTリンパ腫の1例

  筧 康正, Akashi Masaya, 木本 明, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  第70回日本口腔科学会総会・学術大会, Apr. 2016, Japanese, 日本口腔科学会, 福岡, Domestic conference

  Oral presentation


• 腓骨皮弁採取部における一期縫縮と植皮の比較

  渡邊一博, Akashi Masaya, 楠本順哉, Matsumoto Kousuke, 木本 明, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性

  米澤奈津季, Minamikawa Tsutomu, 北島一宏, 高橋佑輔, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討

  筧 康正, Minamikawa Tsutomu, 寺岡 駿, 米澤奈津季, 高橋佑輔, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌患者の遠位レベル（level4,5）への頸部リンパ節転移が予後に与える影響

  定兼啓倫, Hasegawa Takumi, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧 康正, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔扁平上皮癌における外的刺激受容体（TRPVチャネル）の発現

  Sakakibara Akiko, 榊原 俊介, 楠元 順哉, 武田 大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会総会・学術大会, 横浜市, Domestic conference

  Oral presentation


• 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進

  Sakakibara Akiko, 榊原俊介, 楠元順哉, 武田大介, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 口腔癌再発高リスク例に対する高用量CDDP併用術後補助化学放射線療法の検討

  Hasegawa Takumi, 柳本惣市, 大鶴光信, 山川延広, 山田慎一, Minamikawa Tsutomu, 太田嘉英, 梅田正博, 大倉正也, 栗田 浩, 桐田忠昭, 上田倫弘, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Oral presentation


• 局所的炭酸ガス投与による皮弁壊死抑制効果

  齊藤 泉, Hasegawa Takumi, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性（ポスター発表）

  Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会, 横浜, Domestic conference

  Poster presentation


• 移植腓骨と下顎骨の癒合における骨膜温存の重要性

  Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

  第34回日本口腔腫瘍学会総会・学術大会, Jan. 2016, Japanese, 日本口腔腫瘍学会総会・学術大会, 横浜市, Domestic conference

  Oral presentation


• 入院管理下で口腔外科小手術を施行した患者に関する臨床統計

  棚倉 万紀子, 筧 康正, Minamikawa Tsutomu, 高橋 佑輔, 米澤 奈津季, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 超音波断層法による口腔癌頸部リンパ節転移の検討

  筧 康正, Minamikawa Tsutomu, 棚倉 万紀子, 米澤 奈津季, 高橋 佑輔, 松井 太輝, Hasegawa Takumi, Akashi Masaya, 重田 崇至, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 多施設における過去5年の下顎骨骨折症例の検討～下顎智歯と骨折部位の関係

  定兼 啓倫, Hasegawa Takumi, 小林 正樹, 橘彰, 尾古 俊哉, 石田 佳毅, 藤田 剛史, 竹野々 厳, 小松原 秀紀, 竹内 純一郎, 市来 浩司, 宮井 大介, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験

  鰐渕 聡, Akashi Masaya, Hashikawa Kazunobu, 筧 康正, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 抗血栓療法患者における抜歯後出血危険因子についての多施設共同研究－抗凝固療法について－

  小守 紗也華, Hasegawa Takumi, 柳本惣市, 六反田賢, 渋谷 恭之, 橘 進彰, 児島 由佳, 梅田 正博, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 口腔癌術後再発高リスク例に対する放射線化学療法の検討

  Hasegawa Takumi, 柳本惣市, 太田嘉英, 梅田正博, 大倉正也, 栗田 浩, 桐田忠昭, 上田倫弘, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討

  米澤 奈津季, Minamikawa Tsutomu, 北島一宏, 高橋 佑輔, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果

  岩田 英治, Hasegawa Takumi, 武田 大介, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症

  有本 智美, Hasegawa Takumi, 斉藤 泉, 岩田 英治, 武田 大介, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,

  Akashi Masaya, Shibuya Y, Takahashi Satoru, Hashikawa Kazunobu, Hasegawa Takumi, Kakei Y, Negi N, Sekitani T, Komori Takahide

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, English, メルボルン, オーストラリア, International conference

  Oral presentation


• Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,

  Kakei Y, Akashi Masaya, Shigeta T, Takahashi Yutaka, Mastui T, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, English, メルボルン, オーストラリア, International conference

  Oral presentation


• Evaluation of progression level of extracapsular spread for cervical lymph node metastasis of oral squamous cell carcinoma: a multicenter retrospective study.

  Yamada S, Yanamoto S, Hasegawa Takumi, Miyakoshi M, Ooga N, Kamata T, Komori Takahide, Kitagawa Y, Kurita H, Umeda M

  22nd International conference on oral and maxilofacial surgery,, Oct. 2015, English, メルボルン, オーストラリア, International conference

  Oral presentation


• Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．

  松尾 健司, Suzuki Yasuaki, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 順一郎, 古森 孝英

  第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma.．

  武田 大介, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference

  Oral presentation


• 当院における周術期口腔機能管理に関する実態調査と今後の課題

  田村 惠利, 西井 美佳, 冨田 和, 難波 渚, Hasegawa Takumi, Akashi Masaya, Furudoi Shungo, 古森 孝英

  第12回日本口腔ケア学会総会・学術大会．, Jun. 2015, Japanese, 日本口腔ケア学会, 山口, Domestic conference

  Oral presentation


• 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.

  定兼 啓倫, Hasegawa Takumi, 有本 智美, 岡本 奈那, 塩屋園 敦, 立石 千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第25回日本顎変形症学会総会．, Jun. 2015, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Oral presentation


• Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.

  Akashi Masaya, Hashikawa Kazunobu, Kakei Y, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Komori Takahide

  "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, English, 神戸, Domestic conference

  Oral presentation


• Decreased mitochondrial copy numbers in oral squamous cell carcinoma.

  Takeda D, Hasegawa Takumi, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, Jun. 2015, English, 神戸, Domestic conference

  Oral presentation


• -

  難波 渚, 西井 美佳, 冨田 和, 田村 恵利, Hasegawa Takumi, Akashi Masaya, Furudoi Shungo, 古森 孝英

  第12回日本口腔ケア学会総会・学術大会．, Jun. 2015, Japanese, 日本口腔ケア学会, 山口, Domestic conference

  Oral presentation


• 予後不良症例を考える－症例検討会－ 口腔・頸部は制御されたが、肺転移を認めた1例

  Hasegawa Takumi, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会総会, 奈良, Domestic conference

  Oral presentation


• 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討

  齊藤 泉, Hasegawa Takumi, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 当科における放射線性顎骨壊死に関する臨床的検討

  鰐渕 聡, Akashi Masaya, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について

  棚倉 万紀子, Hasegawa Takumi, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 口腔扁平上皮癌臨床検体におけるミトコンドリア量について

  武田 大介, Hasegawa Takumi, 今井 佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Poster presentation


• 口腔癌術後再発ハイリスク因子を規定する被膜外浸潤の伸展度分類

  大谷 昇平, 山田 慎一, 柳本 惣市, Hasegawa Takumi, 宮腰 昌明, 大賀 典孝, 鎌田 孝広, Komori Takahide, 北川 善政, 栗田 浩, 朝比奈泉, 梅田正博

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討

  平岡 佑二郎, Minamikawa Tsutomu, 米澤 奈津季, 高橋 佑輔, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Poster presentation


• 口腔癌原発巣におけるDual-time-point FDG PETの有用性

  米澤 奈津季, Minamikawa Tsutomu, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, 古森 孝英

  第33回日本口腔腫瘍学会, Jan. 2015, Japanese, 日本口腔腫瘍学会, 奈良, Domestic conference

  Oral presentation


• 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価

  有本 智美, Hasegawa Takumi, 定兼 啓倫, 岡本 奈那, 塩屋園 敦, 立石 千鶴, Akashi Masaya, Suzuki Yasuaki, Furudoi Shungo, Komori Takahide

  第25回日本顎変形症学会総会．, Jan. 2015, Japanese, 日本顎変形症学会, 東京, Domestic conference

  Oral presentation


• 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例

  村田 陽太郎, Hasegawa Takumi, 八橋 明子, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Komori Takahide

  第26回日本口腔科学会近畿地方部会, Dec. 2014, Japanese, 日本口腔科学会, 京都, Domestic conference

  Oral presentation


• 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討

  今井 佑輔, Hasegawa Takumi, 川畑 真哉, 武田 大介, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 当科におけるインプラント242例907本埋入に関する臨床的検討

  川畑 真哉, Hasegawa Takumi, 今井 佑輔, Kimoto Akira, Akashi Masaya, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例

  榎本 由依, Suzuki Yasuaki, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 純一郎, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価

  Akashi Masaya, Shibuya Yasuyuki, 鰐渕 聡, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Komori Takahide

  第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference

  Oral presentation


• 当科における上顎洞底挙上術後の骨量変化の臨床的検討

  寺岡 駿, Suzuki Yasuaki, 筧 康正, 石田 優, Kimoto Akira, Hasegawa Takumi, Asai Tomoko, 竹内 純一郎, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 当科における口腔癌患者の術後せん妄に関する臨床的検討

  齊藤 泉, Hasegawa Takumi, 米澤 奈津季, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果

  黄 文蘇, Hasegawa Takumi, 今井 佑輔, 武田 大介, Akashi Masaya, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較

  Akashi Masaya, Shibuya Yasuyuki, 楠元 順哉, Sakakibara Akiko, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 抗RANKLモノクローナル抗体（デノスマブ）に発症した顎骨壊死の1例

  岩田 英治, Akashi Masaya, Hasegawa Takumi, Furudoi Shungo, Komori Takahide

  第23回日本口腔感染症学会総会, Oct. 2014, Japanese, 日本口腔感染症学会, 伊丹, Domestic conference

  Oral presentation


• 口腔扁平上皮癌N0症例への予防的頸部郭清の検討：T1-2とT3-4の比較

  八橋 明子, Minamikawa Tsutomu, 松井 太輝, 高橋 佑輔, 米澤 奈津季, 筧 康正, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 口腔癌手術における輸血療法の現状

  米澤 奈津季, Minamikawa Tsutomu, 高橋 佑輔, 筧 康正, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 口腔癌に対する救済手術についての検討

  筧 康正, Minamikawa Tsutomu, 米澤 奈津季, 高橋 佑輔, 松井 太輝, Sakakibara Akiko, Hasegawa Takumi, Akashi Masaya, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 局所的炭酸ガス投与による口腔癌新規治療法の開発

  武田 大介, Hasegawa Takumi, 今井 佑輔, Sakakibara Akiko, Akashi Masaya, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 急速に増大し巨舌を呈した多発性骨髄腫に伴うアミロイドーシスの1例

  藤田 剛史, 井堂 信二郎, 大槻 有美, 江崎 友美, 北里 佑香, Hasegawa Takumi, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化

  西井 美佳, Akashi Masaya, 筧 康正, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• フェーズラグCT（pl-CTA）による顎骨周囲の脈管の評価

  Sakakibara Akiko, Sakakibara Shunsuke, Hasegawa Takumi, Akashi Masaya

  第59回日本口腔外科学会総会・学術集会, Oct. 2014, Japanese, 日本口腔外科学会, 幕張, Domestic conference

  Oral presentation


• フェーズラグCTA（ｐｌ－CTA）による顎動静脈分岐の評価

  Sakakibara Akiko, Sakakibara Shunsuke, 楠元 順哉, Hasegawa Takumi, Akashi Masaya, Suzuki Yasuaki, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討

  岩田 英治, Akashi Masaya, 楠元 順哉, Hasegawa Takumi, 後藤 育子, Furudoi Shungo, Komori Takahide

  第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Poster presentation


• 顎矯正手術における超音波診断法と単純MRI画像を用いた顎動脈の走行位置評価

  有本 智美, Hasegawa Takumi, 金子 児太郎, 岡本 奈那, 塩屋園 敦, 立石 千鶴, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第24回日本j顎変形症学会総会, Jun. 2014, Japanese, 日本顎変形症学会, 福岡, Domestic conference

  Oral presentation


• 口腔癌再建術後の頸部感染評価目的でのCTの有用性

  Akashi Masaya, Furudoi Shungo, Minamikawa Tsutomu, Kimoto Akira, Sakakibara Akiko, Hasegawa Takumi, 後藤 育子, Shibuya Yasuyuki, Komori Takahide

  第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference

  Oral presentation


• 口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討

  筧 康正, Minamikawa Tsutomu, 高橋 佑輔, 松井 太輝, Hasegawa Takumi, Akashi Masaya, 重田 崇至, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第32回日本口腔腫瘍学会, Jan. 2014, Japanese, 日本口腔腫瘍学会, 札幌, Domestic conference

  Oral presentation


• 40歳未満に発生した舌扁平上皮癌21例の検討

  高橋 佑輔, Minamikawa Tsutomu, Hasegawa Takumi, 米澤 奈津季, 筧 康正, 松井 太輝, Sakakibara Akiko, 重田 崇至, Shibuya Yasuyuki, Komori Takahide

  第32回日本口腔腫瘍学会, Jan. 2014, Japanese, 日本口腔腫瘍学会, 札幌, Domestic conference

  Oral presentation


• 頸部郭清術後に発症した偽膜性腸炎から中毒性巨大結腸症に至った1例

  岩田英治, Furudoi Shungo, 高橋佑輔, Hasegawa Takumi, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第22回口腔感染症学会総会, Nov. 2013, Japanese, 口腔感染症学会, 八王子, Domestic conference

  Oral presentation


• 当科におけるインプラントの撤去に至った21症例の臨床的検討

  高端大希, Suzuki Yasuaki, 石田 優, Hasegawa Takumi, Asai Tomoko, Takeuchi Junichi, Shibuya Yasuyuki, Komori Takahide

  第17回顎顔面インプラント学会総会, Nov. 2013, Japanese, 顎顔面インプラント学会, 東京, Domestic conference

  Oral presentation


• 下顎のスプリットクレスト法において遊離骨片が生じた6例の臨床的検討

  八橋明子, 石田 優, 仲村百合香, 小林正樹, Hasegawa Takumi, Suzuki Yasuaki, Shibuya Yasuyuki, Komori Takahide

  第17回顎顔面インプラント学会総会, Nov. 2013, Japanese, 顎顔面インプラント学会, 東京, Domestic conference

  Oral presentation


• CT画像における下顎骨舌側にみられる骨孔の観察

  Asai Tomoko, Shibuya Yasuyuki, 仲村百合香, Hasegawa Takumi, Suzuki Yasuaki, Komori Takahide

  第17回顎顔面インプラント学会総会, Nov. 2013, Japanese, 顎顔面インプラント学会, 東京, Domestic conference

  Oral presentation


• 放射線治療を伴う上顎切除後に骨移植を併用したインプラント顎義歯を用いて機能回復を行った1例

  井堂信二郎, 小林正樹, Hasegawa Takumi, Suzuki Yasuaki, Shibuya Yasuyuki, Komori Takahide

  第33回日本口腔インプラント学会近畿北陸支部学術大会, Oct. 2013, Japanese, 日本口腔インプラント学会, 神戸, Domestic conference

  Oral presentation


• 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．

  Akashi Masaya, 橋川 和信, 榊原 晶子, Hasegawa Takumi, Shigeta Takashi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会・学術大会, Oct. 2013, Japanese, 日本口腔外科学会総会・学術大会, 福岡市, Domestic conference

  Oral presentation


• 抗血栓療法下での抜歯後出血の臨床的検討

  松本耕祐, 李 進彰, 宮井大介, 柚鳥宏和, Shigeta Takashi, Hasegawa Takumi, 津々見由里, 小守紗也華, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 口腔癌頸部郭清術後の郭清範囲内および境界領域における頸部再発に関する検討

  高橋佑輔, Minamikawa Tsutomu, 米澤奈津季, 榊原晶子, 筧 康正, 松井太輝, Hasegawa Takumi, Shigeta Takashi, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-

  米澤奈津季, Minamikawa Tsutomu, Akashi Masaya, 高橋佑輔, Hasegawa Takumi, 榊原晶子, Shigeta Takashi, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 下顎骨骨折血腫由来細胞の骨分化能に対するBP製剤の効果

  今井佑輔, Hasegawa Takumi, 武田大介, 黄 文蘇, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Poster presentation


• ミトコンドリア経路に関連した口腔癌新規治療法の開発

  武田大介, Hasegawa Takumi, 今井佑輔, 榊原晶子, Shigeta Takashi, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討

  Shigeta Takashi, Minamikawa Tsutomu, 松井太輝, Akashi Masaya, Hasegawa Takumi, 高橋佑輔, 筧 康正, Shibuya Yasuyuki, 梅田正博, Komori Takahide

  第58回日本口腔外科学会総会, Oct. 2013, Japanese, 日本口腔外科学会, 福岡, Domestic conference

  Oral presentation


• 下顎枝垂直骨切り術術後における口腔内・口腔外知覚神経障害の経時的変化に関する検討

  浅井雅敏, 立石千鶴, Hasegawa Takumi, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第29回兵庫県歯科医学大会総会, Aug. 2013, Japanese, 兵庫県歯科医学大会, 神戸, Domestic conference

  Oral presentation


• 舌背部に生じた顆粒細胞腫の1例

  岩田英治, Hasegawa Takumi, 安岡大介, 高橋佑輔, Shigeta Takashi, Minamikawa Tsutomu, Shibuya Yasuyuki, Komori Takahide

  第44回日本口腔外科学会近畿支部学術集会, Jun. 2013, Japanese, 日本口腔外科学会, 神戸, Domestic conference

  Oral presentation


• 外科的矯正治療により咬合改善を得た上下顎の歯数不調和を伴う下顎骨骨折変形治癒症例

  浅井雅敏, 立石千鶴, 岡本奈那, Hasegawa Takumi, 筧 康正, Takeuchi Junichi, Suzuki Yasuaki, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第23回日本顎変形症学会総会, Jun. 2013, Japanese, 日本顎変形症学会, 大阪, Domestic conference

  Poster presentation


• 53歳下顎側方偏位症例に対し外科的矯正治療を行った1例

  塩屋園敦, 立石千鶴, Hasegawa Takumi, 今井佑輔, Takeuchi Junichi, Suzuki Yasuaki, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第23回日本顎変形症学会総会, Jun. 2013, Japanese, 日本顎変形症学会, 大阪, Domestic conference

  Poster presentation


• 放射線治療後に照射範囲外から骨移植を行ったインプラント治療の検討

  中條泰宏, Shibuya Yasuyuki, 石田 優, Hasegawa Takumi, Takeuchi Junichi, 小林正樹, Komori Takahide

  第67回日本口腔科学会総会, May 2013, Japanese, 日本口腔科学会, 宇都宮, Domestic conference

  Oral presentation


• 口腔癌患者への緩和ケアチームの介入についての臨床的検討

  米澤奈津季, Minamikawa Tsutomu, 高橋佑輔, 榊原晶子, Hasegawa Takumi, 高田直樹, Takeuchi Junichi, Shigeta Takashi, Shibuya Yasuyuki, Komori Takahide

  第31回日本口腔腫瘍学会総会, Jan. 2013, Japanese, 日本口腔腫瘍学会, 東京, Domestic conference

  Oral presentation


• 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価

  Akashi Masaya, 橋川 和信, 榊原 晶子, Hasegawa Takumi, Shigeta Takashi, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  第57回日本口腔外科学会総会・学術大会, Oct. 2012, Japanese, 日本口腔外科学会, 横浜, Domestic conference

  Oral presentation


• 舌部分切除手術パス作成の取り組み

  Hasegawa Takumi, 李 進彰, 井堂 信二郎, Shigeta Takashi, 吉武 賢, 中野 沙織, 富本 貴子

  第11回日本クリニカルパス学会学術集会, Dec. 2010, Japanese, 日本クリニカルパス学会, 松山, Domestic conference

  Oral presentation


• 下顎骨再建に生体吸収性材料HA/PLLA複合体を使用した1例

  Hasegawa Takumi, 李 進彰, 後藤 育子, 吉武 賢, 中野 沙織, Komori Takahide

  第14回日本顎顔面インプラント学会総会, Dec. 2010, Japanese, 日本顎顔面インプラント学会, 千葉, Domestic conference

  Oral presentation


• 抗血栓療法患者の歯科処置における止血困難症例の3症例

  中野 沙織, 李 進彰, 井堂 信二郎, Shigeta Takashi, Hasegawa Takumi, 梅田 正博, Komori Takahide

  第27回日本障害者歯科学会総会, Oct. 2010, Japanese, 日本障害者歯科学会, 東京, Domestic conference

  Oral presentation


• NBI，ルゴール染色の併用により早期に発見し得た舌表在癌の検討．

  Hasegawa Takumi, 李 進彰, 井堂信二郎, Shigeta Takashi, 吉武 賢, 中野沙織, 梅田正博, Komori Takahide

  第55回日本口腔外科学会総会, Oct. 2010, Japanese, 日本口腔外科学会, 千葉, Domestic conference

  Oral presentation


• 下顎骨腫瘍

  大林 真理子, 小川 郁子, 李 進彰, 井堂 信二郎, Shigeta Takashi, Hasegawa Takumi, 中野 沙織, Yokozaki Hiroshi, 宮内 睦美, 高田 隆

  第102回日本病理学会中国四国支部学術集会, Jul. 2010, Japanese, 日本病理学会, 米子, Domestic conference

  Oral presentation


• 抗凝固薬継続下で歯科観血的処置を行った256例の検討-後出血の頻度と対策について

  吉武 賢, 梅田 正博, Murata Maho, Hasegawa Takumi, Shigeta Takashi, 井堂 信二郎, 李 進彰, Komori Takahide

  第64回日本口腔科学会総会, Jun. 2010, Japanese, 日本口腔科学会, 札幌, Domestic conference

  Oral presentation


• 口腔外科手術時の開放創に対するPGAシートおよびフィブリン糊スプレーの使用経験（第2報） 早期脱落の原因と対処法

  Murata Maho, 梅田 正博, Takeuchi Junichi, Suzuki Yasuaki, Komori Takahide, Hasegawa Takumi, 井堂 信二郎, 李 進彰

  第64回日本口腔科学会総会, Jun. 2010, Japanese, 日本口腔科学会, 札幌, Domestic conference

  [Invited]

  Invited oral presentation


• 下顎知歯抜歯後の下唇知覚鈍麻と術前のパノラマX線および多断面再構成CT画像所見との関係

  Hasegawa Takumi, 李 進彰, 梅田 正博, 有馬 宏美, 高橋 英哲, Shigeta Takashi, 井堂 信二郎, Komori Takahide

  第64回日本口腔科学会総会, Jun. 2010, Japanese, 日本口腔科学会, 札幌, Domestic conference

  Oral presentation


• 抗血栓療法継続下での歯科観血的処置後の出血の現状と対策

  Shigeta Takashi, 李 進彰, Hasegawa Takumi, 井堂信二郎, 梅田正博, Murata Maho, Minamikawa Tsutomu, Furudoi Shungo, Shibuya Yasuyuki, Komori Takahide

  Apr. 2010, Japanese, 第19回日本有病者歯科医療学会, 神戸, Domestic conference

  Oral presentation


• 口底部に発生した神経鞘腫の1例

  有馬宏美, 李 進彰, 井堂信二郎, Shigeta Takashi, Hasegawa Takumi, Komori Takahide

  Jan. 2010, Japanese, 第28回日本口腔腫瘍学会総会, 東京, Domestic conference

  Oral presentation


• ヒト新鮮骨折において、低出力超音波パルス（ＬＩPUS)は骨折血腫由来細胞の分化を促進し骨形成に作用する

  岩倉崇, Hasegawa Takumi, 三輪雅彦, Niikura Takahiro, Sakai Yoshitada, 大江啓介, Lee Sangyang, Kurosaka Masahiro

  第35回日本骨折治療学会, Jul. 2009, Japanese, 日本骨折治療学会, 横浜, Domestic conference

  Poster presentation

• 顎骨壊死に対する腐骨分離促進療法の探索

  明石 昌也, 重岡 学, 有本 智美, 木本 明, 長谷川 巧実, 筧 康正

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026


• Multicenter study of circulating tumor cells and circulating tumor DNA involved in distant metastasis of oral cancer

  柳本 惣市, 山川 延宏, 本田 一文, 栗田 浩, 大倉 正也, 山田 慎一, 長谷川 巧実, 太田 嘉英, 梅田 正博, 桐田 忠昭, 上田 倫弘

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Hiroshima University, 01 Apr. 2022 - 31 Mar. 2026


• ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発

  長谷川 巧実, 榊原 晶子, 明石 昌也, 武田 大介

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026


• 環境因子による細胞内シグナル増強と腫瘍悪性化についての相関の解明

  榊原 晶子, 長谷川 巧実, 榊原 俊介, 楠元 順哉

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2025

  これまでのわれわれの研究では、生体から得られた口腔粘膜組織（舌、歯肉、 粘膜、口底）の癌細胞と正常粘膜細胞を用いてTRPV1-4イオンチャネルの発現が癌と正常組織でどのように特徴付けられるのかを 証してきた。 （real time PCR法および、免疫組織化学染色法により、①TRPV1,2,3,4全てにおいて、ヒト口腔正常粘膜（舌、歯肉、 粘膜、口底）での発現を確認。②口腔扁平上皮癌と口腔正常粘膜におけるTRPV1,2,3,4の発現量は、扁平上皮癌の方が有意に 増加。③TRPV1,2,3,4全てにおいて、ヒト口腔正常粘膜で‘飲酒あり’群の方が、‘飲酒なし’群よりも有意に増加。④TRPV2,3,4において、ヒト口腔正常粘膜で‘喫煙あり’群の方が、‘喫煙なし’群よりも有意に増加しており、TRPV1も増加傾向。） これまでの研究は、生体から採取した粘膜癌細胞、粘膜正常細胞から採取した組織で行った。培養細胞においても同様な発現が認められるのかを検証中である。生体から採取した組織から細胞を 離しようと試みたが、困難であったため、細胞提供を受けて、培養している。正常粘膜細胞の培地と癌細胞の培地でまずは光刺激でカルシウムイオンチャネルが開くことを確認している。TRPVイオンチャネルの1-4のそれぞれに特有のチャネルを開くアゴニスト （例：カプサイシンやさまざまな温度設定）があるため、おのおので検証してきた。


• Molecular biological analysis of extracapsular spread of cervical lymph node metastasis in oral squamous cell carcinoma/

  山田 慎一, 栗田 浩, 柳本 惣市, 長谷川 巧実, 梅田 正博, 桐田 忠昭

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), University of Toyama, 01 Apr. 2021 - 31 Mar. 2024

  口腔癌の頸部リンパ節転移の被膜外浸潤は術後再発高リスク因子であり、その臨床的意義は大きい。しかしながら、被膜外浸潤の診断にはばらつきがあり、被膜外浸潤症例の中でも予後が別れており、真の術後補助療法の適応例を同定するためには、被膜外浸潤の分類の確立と、その病理組織学的、分子生物学的な裏付けが必要である。われわれが以前に設定した被膜外浸潤の進展度分類と、PD-L1などのマーカーとに関連を明らかにすることで、術後補助療法の適応症例の確立を図る。頸部リンパ節の被膜外浸潤進展症例の症例集積ならびに検体集積を行う予定であったが、被膜外浸潤例の検体収集に問題があり、また、研究代表者の異動に伴い大きな進展ができなかった。被膜外浸潤例のPD-L1の発現について免疫組織学的染色を行っており、被膜外浸潤の進展度分類との関連を検討中である。 また、口腔領域の悪性黒色腫の症例を多施設共同研究の形態で集積し検討を行った。過去21年間69例の口腔粘膜悪性黒色腫症例の2年全生存率、5年全生存率はそれぞれ64.6%、42.5％であった。病期別ではstage IIIの2年全生存率、5年全生存率は85.9％、72.5％、stage IVAでは56.3％、26.0％であり、病期が進展すると有意に予後不良であった。根治的治療を行った群では2年および5年全生存率は74.1％、50.5％であり非根治的治療群に比べて有意に予後が良好であった。手術療法群での全生存に寄与する因子として病期が独立した有意な予後因子として抽出された。


• 血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索

  明石 昌也, 木本 明, 長谷川 巧実, 筧 康正

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2023


• Analysis of fusion gene of salivary gland carcinogenesis and explore the molecular target agents

  野口 一馬, 寺田 友紀, 山根木 康嗣, 柳本 惣市, 岸本 裕充, 鵜澤 成一, 中野 芳朗, 長谷川 巧実

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Hyogo College of Medicine, 01 Apr. 2019 - 31 Mar. 2022

  兵庫医科大学 歯科口腔外科学講座で病理組織学的に診断し、外科的に加療した唾液洗顔における融合遺伝子の検討を行った。遺伝子解析までに至った症例は粘表皮癌3例、腺様嚢胞癌1例、多型腺腫由来癌1例である。いずれの唾液腺癌も過去の報告より有力とされる融合遺伝子の存在が示唆されており、PCR法および sanger法を用いて融合遺伝子の存在を解析した。粘表皮癌ではCRTC1-MAML2またはCRTC3-MAML2の融合が発癌と示唆されているが自検例では2/3にCRTC1-MAML2の発現を確認した。このうち1例より、細胞を試み、培養細胞株化に成功した。さらに粘表皮癌にはこれまで報告されていなかった新たなバイオマーカー候補の存在をRNAシークエンスから見つけ出し、病理組織学的な意義について検討した。 腺様嚢胞癌および多型腺腫由来癌においても融合遺伝子の存在は明らかになりつつあり、これらについても融合遺伝子の関与を検討したが、我々が行なった2例とも融合遺伝子の存在は確認されなかった。これらの結果より唾液腺発癌において融合遺伝子の関与は一部の白血病のように全てではないものの、関与をしていることが明らかになり、融合遺伝子が発癌に関与しているものについては将来、分子標的治療の対象となり得ると考えられ、唾液腺癌に対する遺伝子解析の重要性を示唆しているものと思われた。


• A multicenter prospective study for elucidating the risk factors and establishing prevention methods of medical-related osteonecrosis of the jaws (MRONJ) .

  兒島 由佳, 岩井 大, 五月女 さき子, 長谷川 巧実, 梅田 正博, 船原 まどか

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kansai Medical University, 01 Apr. 2019 - 31 Mar. 2022

  ビスホスホネート製剤やデノスマブ製剤などの骨吸収抑制薬は破骨細胞活性を抑制することにより強力な骨吸収抑制作用を示し、骨粗鬆症患者の骨折予防、がんの骨転移や多発性骨髄腫患者の骨関連事象の予防薬として広く用いられている。しかし重大な有害事象の一つとして、薬剤関連顎骨壊死（MRONJ）の発症が問題となっている。MRONJの発症頻度は近年増加しており難治性であるが、高用量の注射骨吸収抑制薬が投与されているがん患者では特に発症率が高い。MRONJの原因として抜歯などの骨への侵襲が考えられてきたが、抜歯そのものではなく抜歯する歯に存在する局所感染がMRONJの原因であり、感染源になる歯は積極的に抜歯をしたほうがいいのではないかという考えも提唱されるようになった。本研究は「感染源になりうる歯を持つ場合、抜歯・保存のいずれがMRONJ発症率を下げることができるか」「抜歯をする場合はどのような手技で抜歯を行えばMRONJ発症率を下げることができるか」「抜歯をしない場合は良好な口腔衛生状態を保つことによりMRONJ発症率を下げることができるか」「抜歯例において 抜歯窩内の細菌感染とMRONJ発症率に関連があるか」「 抜歯をする際の休薬の有無や期間と、抜歯窩周囲歯槽骨の破骨細胞活性に関連はあるか」などを解明することを目的とした多施設共同前向き研究である。


• 治療抵抗性の改善と副作用の軽減を目指した革新的ながん治療法の開発応用

  長谷川 巧実

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2022, Principal investigator

  Competitive research funding


• 口腔癌頸部リンパ節転移被膜外浸潤進展度分類と進展メカニズムの分子細胞生物学的研究

  山田 慎一, 栗田 浩, 大倉 正也, 柳本 惣市, 長谷川 巧実, 太田 嘉英, 梅田 正博, 桐田 忠昭

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Shinshu University, 01 Apr. 2018 - 31 Mar. 2021

  本年度は①口腔癌の頸部リンパ節転移の被膜外浸潤症例において、われわれが設定した進展度分類（Yamada S, et al., 2015.）を行い、臨床病理学的因子、予後との相関 を検討し、予後予測因子あるいは術後補助療法適用の指標となり得るかを検討する。②それぞれの進展度分類において、被膜外浸潤最先端部の腫瘍細胞組織をマイクロダイセクション法を用いて選択的に採取し、マイクロアレイを用いて、それぞれの被膜外浸潤進展度の腫瘍細胞の遺伝子発現プロファイルを網羅的に検討し、被膜外浸潤の進展に関与する分子を同定する、ことを計画した。 口腔扁平上皮癌の頸部リンパ節転移があり、被膜外浸潤症例の集積ならびに観察項目のデータ収集を行った。被膜外浸潤症例について、われわれが設定した被膜外浸潤の進展度分類に基づいて分類を行った。また、該当症例について、パラフィンブロックより、薄切標本を作製した。被膜外浸潤および進展度分類に影響する分子について、特に今回は細胞の運動に関連するアクチン束状化タンパクであるactinin-4について免疫組織化学的染色を行い、その発現と臨床病理組織学的因子との関連について検討を行うこととした。しかしながら、リンパ節の薄切標本は比較的大きいことから、免疫組織化学的染色が困難であり、安定的に免疫組織化学的染色を行って評価可能な標本を得ることは困難であった。引き続き、免疫組織化学的染色の染色を安定的にリンパ節標本においても行えるように検討を行い、合わせてマイクロダイセクションの実施を行う。


• 放射線性多発う蝕の発生機序の解明と予防法に関する多施設共同ランダム化比較試験

  五月女 さき子, 梅田 正博, 長谷川 巧実, 山田 慎一, 渋谷 恭之, 上田 順宏, 兒島 由佳, 山口 泰平

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Nagasaki University, 01 Apr. 2017 - 31 Mar. 2020

  頭頸がんに対する放射線治療（RT）の重篤な晩期有害事象の一つに放射線性顎骨壊死（ORN）がある。照射方法の進歩とともにORNの発症頻度は近年では低くなってきたが、依然として10～20%程度の患者に発症し、患者のQOLを低下させる大きな原因となっている。 実際にRT前と1年後、2年後のパノラマＸ線写真を比較したところ、急速にう蝕が進行する患者が少なからず存在することを確認した。う蝕多発者では唾液腺だけではなく歯に対する照射線量が60Gy以上と多かったが、口腔衛生状態はう蝕が発生しなかった患者と差はなく、さらに上顎あるいは下顎のみに照射された患者では照射された顎にのみう蝕が多発することや、片側の照射例では照射された側にのみう蝕が多発することが明らかとなった。本研究は、1）RT後の多発う蝕の実態を多施設共同後ろ向き観察研究で明らかにすること、2）RT後に歯を含む歯槽部が切除された患者の切除検体を用いてRTによる歯の直接障害の有無や程度について調べること、および3）トレー法によるフッ化物局所応用によりRT後のう蝕多発が予防できるかどうかを多施設共同ランダム化比較試験により検証することを目的とするものである。そこでまずは後ろ向きに調査した。その後ろ向き研究では、口腔がん手術単独例では2年後のう蝕増加数は0.6歯であったのに対して、RT患者では4.9歯と有意に多かった。放射線性う蝕の特徴としては、①歯頸部からの発生が多い、②疼痛などの自覚症状に乏しい、③歯頸部から歯が破折して初めて発見されることも少なくない，④歯の黒変，あるいは歯冠歯質の軟化がみられることもある、⑤歯質の欠損がない、あるいはC2までの状態で歯根膜腔の拡大や根尖病巣を認めるというものであった。そこで実際に頭頸部がんRT患者10例を1年間観察したところ新たなう蝕の発生はみられなかった。


• A multicenter study of elucidation of status and risk factors of osteoradionecrosis of the jaw

  KOJIMA Yuka

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kansai Medical University, 01 Apr. 2016 - 31 Mar. 2019

  A multicenter study of 392 patients with head and neck cancer receiving radiotherapy from 2008 to 2014 revealed that primary site (oral or oropharyngeal cancer), periapical lesion at the start of radiotherapy, and tooth extraction after radiotherapy were independent risk factors for development of osteoradionecrosis of the jaw (ORN) by multivariate analysis of Cox regression. Investigations of 30 patients who developed ORN showed that most lesions occurred in the lower jaw and the frequent triggers for ORN were periapical lesion, extraction after radiotherapy, and radiation-induced dental caries. The occurrence rate of ORN in patients with oral or oropharyngeal cancer receiving radiotherapy from 2015 to 2017 was higher than those treated before 2015, although the reason was not unclear and further investigation is necessary.


• 局所的炭酸ガス投与による口腔癌転移抑制効果の検討

  長谷川 巧実

  学術研究助成基金助成金／若手研究(B), Apr. 2015 - Mar. 2018, Principal investigator

  Competitive research funding


• ミトコンドリアをターゲットとした口腔癌新規治療法の開発

  長谷川 巧実

  科学研究費補助金／若手研究(B), Apr. 2012 - Mar. 2015, Principal investigator

  Competitive research funding