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KAKEJI YoshihiroGraduate School of Medicine / Faculty of Medical SciencesProfessor
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■ Paper- Springer Science and Business Media LLC, Dec. 2024, Surgery TodayScientific journal
- Springer Science and Business Media LLC, Dec. 2024, Esophagus, 22(1) (1), 37 - 46Scientific journal
- Anticancer Research USA Inc., Dec. 2024, Anticancer Research, 44(12) (12), 5485 - 5493Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 101934 - 101934Scientific journal
- Elsevier BV, Dec. 2024, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007Scientific journal
- Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.Wiley, Nov. 2024, World Journal of SurgeryScientific journal
- Abstract Developmental cyst is occasionally seen in children but are less common in adults. Complete removal of developmental cyst is necessary because there are risk of infection, squamous cell carcinoma, and recurrence due to incomplete resection. The best approach for resection of developmental cyst is still controversial. Although transsacral approach, open abdominal approach, or a combination of both have been often employed to date, reports of laparoscopic surgery have been appearing in recent years. We performed laparoscopic surgery for four patients with this disease: (i) 29‐year‐old woman with epidermoid cyst; (ii) 21‐year‐old woman with dermoid cyst; (iii) 55‐year‐old woman with epidermoid cyst; and (iv) 77‐year‐old woman with epidermoid cyst. No perioperative complications occurred and no recurrence has developed so far in any patients. Laparoscopic surgery can be considered as one of the optimal treatment options for developmental cyst.Wiley, Nov. 2024, Asian Journal of Endoscopic Surgery, 18(1) (1)Scientific journal
- Nov. 2024, 臨牀消化器内科, 39(12) (12), 1528, Japanese第79回 日本消化器外科学会総会
- Cancer-associated fibroblasts (CAFs) are a key component of the tumor microenvironment and significantly contribute to the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). Our previous study established a direct co-culture system of human bone marrow-derived mesenchymal stem cells (progenitors of CAFs) and ESCC cell lines, which facilitates the generation of CAF-like cells and enhances malignancy in ESCC cells. In this study, we further elucidated the mechanism by which CAFs promote ESCC progression using cDNA microarray analysis of monocultured ESCC cells and those co-cultured with CAFs. We observed an increase in the expression and secretion of amphiregulin (AREG) and the expression and phosphorylation of its receptor EGFR in co-cultured ESCC cells. Moreover, AREG treatment of ESCC cells enhanced their survival and migration via the EGFR-Erk/p38 MAPK signaling pathway. Immunohistochemical analysis of human ESCC tissues showed a positive correlation between the intensity of AREG expression at the tumor-invasive front and the expression level of the CAF marker FAP. Bioinformatics analysis confirmed significant upregulation of AREG in ESCC compared with normal tissues. These findings suggest that AREG plays a crucial role in CAF-mediated ESCC progression and could be a novel therapeutic target for ESCC.MDPI AG, Oct. 2024, Cells, 13(20) (20), 1733 - 1733Scientific journal
- Springer Science and Business Media LLC, Sep. 2024, Surgery TodayScientific journal
- Springer Science and Business Media LLC, Sep. 2024, Esophagus, 22(1) (1), 59 - 67Scientific journal
- Abstract Esophagectomy for esophageal cancer is a highly invasive gastrointestinal surgical procedure. The National Clinical Database (NCD) of Japan, initiated in 2011, has compiled real-world data on esophagectomy, one of nine major gastroenterological surgeries. This review examines outcomes after esophagectomy analyzed using the Japanese big databases. Certification systems by the Japanese Society of Gastroenterological Surgery (JSGS) and the Japan Esophageal Society (JES) have shown that institutional certification has a greater impact on short-term surgical outcomes than surgeon certification. Minimally invasive esophagectomy has emerged as a viable alternative to open esophagectomy, although careful patient selection is crucial, especially for elderly patients with advanced tumors. The NCD has significantly contributed to the assessment and enhancement of surgical quality and short-term outcomes, while studies based on Comprehensive Registry of Esophageal Cancer in Japan (CRECJ) have provided data on patient characteristics, treatments, and long-term outcomes. The JES has conducted various questionnaire-based retrospective clinical reviews in collaboration with authorized institutions certified by JES. The Diagnosis Procedure Combination (DPC) database provides administrative claims data including itemized prices for surgical, pharmaceutical, laboratory, and other inpatient services. Analyzing these nationwide databases can offer precise insights into surgical quality for esophageal cancer, potentially leading to improved treatment outcomes.Lead, Springer Science and Business Media LLC, Aug. 2024, Esophagus, 21(4) (4), 411 - 418Scientific journal
- Springer Science and Business Media LLC, Aug. 2024, EsophagusScientific journal
- Background: Perforated peptic ulcer (PPU) causes peritonitis and requires surgery based on disease severity. This study aimed to develop and validate a severity scale for PPU with generalized peritonitis. Materials and methods: This retrospective cohort study used a nationwide multi-center surgical database (2013–2020). Patients aged >15 years who underwent surgery for PPU with generalized peritonitis were included and categorized into the derivation (2013–2018) and two validation (2019 and 2020) cohorts. Possible severity predictors were selected via a literature review, and Lasso models were developed to predict severe postoperative adverse events with 2000 bootstrapping. Final variables for the scoring system were determined based on inclusion frequency (≥90%) in the Lasso models. Discrimination and accuracy were evaluated using c-statistics and calibration plots. Cutoff values for minimal postoperative adverse events were examined using negative predictive values. Results: Among 12,513 patients included (1,202 underwent laparoscopic surgery), 533 (5.9%), 138 (7.6%), and 117 (6.9%) in the derivation and two validation cohorts experienced postoperative adverse events. Age, dyspnea at rest, preoperative sepsis, III/IV/V of American Society of Anesthesiologists physical status, and albumin and creatinine were selected for the final model. A 0–11 scoring system was developed with c-statistics of 0.812–0.819. Cutoff value was determined as 5, which predicted <3% probability of postoperative adverse events regardless of type of surgery. Conclusions: A score of <5 predicts minimal risks for postoperative adverse events and therefore would be clinically useful to determine type of surgery. Further studies are needed to validate the score.Ovid Technologies (Wolters Kluwer Health), Aug. 2024, International Journal of SurgeryScientific journal
- Lead, Aug. 2024, 臨床外科, 79(8) (8), 840 - 844National Clinical Detabase からみる食道癌術後合併症と手術死亡率Scientific journal
- Anticancer Research USA Inc., Jul. 2024, Anticancer Research, 44(8) (8), 3553 - 3556Scientific journal
- BACKGROUND: The significance of resection of paraaortic lymph node metastasis in colorectal cancer is controversial. OBJECTIVE: To clarify the prognosis of colorectal cancer after paraaortic lymph node metastasis resection. DESIGN: Multicenter retrospective study. SETTINGS: Thirty-six institutions in Japan participated in this study. PATIENTS: Patients with resected and pathologically proven paraaortic lymph node metastasis of CRC between 2010 and 2015. DATA SOURCES: Database and medical records at each institution. MAIN OUTCOME MEASURES: Overall survival after paraaortic lymph node metastasis resection, recurrence-free survival, and recurrence patterns after R0 resection of paraaortic lymph node metastasis. RESULTS: A total of 133 patients were included in the primary analysis population in this study. The 5-year overall survival rate (95% confidence interval [CI]) was 41.0% (32.0, 49.8), and the median survival (95% CI) was 4.1 (3.4, 4.7) years. Independent prognostic factors for overall survival were the pathological T stage (pT4 vs. pT1– 3, adjusted hazard ratio [aHR]: 1.91, p = 0.006), other organ metastasis (present vs. absent, aHR: 1.98, p = 0.005), time to metastases (synchronous vs. metachronous, aHR: 2.02, p = 0.02), and number of paraaortic lymph node metastasis (≥3 vs. <3, aHR: 2.13, p = 0.001). The 5-year recurrence-free survival rate (95% CI) was 21.1% (13.5, 29.7), with a median (95% CI) of 1.2 (0.9, 1.4) years. The primary tumor location (left- vs. right-sided colon, aHR: 4.77, p = 0.01; rectum vs. right-sided colon, aHR: 5.27, p = 0.006), other organ metastasis (present vs. absent, aHR: 1.90, p = 0.03), number of paraaortic lymph node metastasis (≥3 vs. <3, aHR: 2.20, p = 0.001), and hospital volume (<10 vs. ≥10, aHR: 2.18, p = 0.02) were identified as independent prognostic factors for recurrence-free survival. Paraaortic lymph node recurrence was the most common at 33.3%. LIMITATIONS: Selection bias cannot be ruled out because of the retrospective nature of the study. CONCLUSIONS: Less than three paraaortic lymph node metastasis was a favorable prognostic factor for both overall survival and recurrence-free survival. However, paraaortic lymph node metastases were considered to be a systemic disease and the significance of resection was limited. See Video Abstract.Ovid Technologies (Wolters Kluwer Health), Jul. 2024, Diseases of the Colon & RectumScientific journal
- Springer Science and Business Media LLC, Jun. 2024, Surgery TodayScientific journal
- Abstract Background Herein, we report a case of gastric antrum cancer with multiple invasions to other organs that was completely cured with laparoscopic distal gastrectomy after preoperative chemotherapy in a patient with poor general condition. Case presentation An 80-year-old male patient was diagnosed with anemia during follow-up for cerebral lacunar infarction at another hospital. He was diagnosed with advanced-stage gastric antrum cancer and was referred to our hospital. On esophagogastroduodenoscopy, type 2 advanced-stage gastric cancer was detected at the greater curvature of the antrum, and the biopsy results revealed tubular adenocarcinoma. Contrast-enhanced computed tomography scan revealed multiple invasions to other organs, thick gastric wall with contrast effect, and superior mesenteric vein tumor thrombus. However, there was no evidence of distant metastasis on positron emission tomography/computed tomography scan. The clinical diagnosis was stage IVA gastric cancer. Pancreatoduodenectomy with portal vein resection could be important at this point. However, preoperative chemotherapy with S-1 and oxaliplatin was administered instead of performing extended surgery because the patient had poor general condition (performance status score of 3). The patient received three cycles of preoperative chemotherapy at the hospital along with rehabilitation and nutritional management with oral nutritional supplements. After treatment, the performance status score of the patient improved from 3 to 1. Furthermore, in terms of clinical therapeutic effect, the patient achieved partial response. Hence, laparoscopic distal gastrectomy with D2 lymph node dissection and partial transverse colectomy was performed. After surgery, the patient was admitted for oral intake on postoperative day 6 and was discharged on postoperative day 21. Based on the histopathological examination, gastric cancer had disappeared, and there were no evident malignant findings. Therefore, gastric cancer was classified as grade 3 according to the histological treatment efficacy criteria. The patient did not present with recurrence at 2 years after surgery. Conclusions By actively administering preoperative chemotherapy, minimally invasive radical surgery with maximum preservation of the surrounding organs can be performed for locally far advanced-stage gastric cancer in older patients with poor general condition.Springer Science and Business Media LLC, Jun. 2024, Surgical Case Reports, 10(1) (1)Scientific journal
- Springer Science and Business Media LLC, Jun. 2024, Gastric Cancer, 27(5) (5), 1157 - 1157Scientific journal
- Springer Science and Business Media LLC, Jun. 2024, Langenbeck's Archives of Surgery, 409(1) (1)Scientific journal
- 日本ストーマ・排泄リハビリテーション学会, Jun. 2024, 日本ストーマ・排泄リハビリテーション学会誌, 40(2) (2), 46 - 61, Japanese
- Springer Science and Business Media LLC, May 2024, Surgical Endoscopy, 38(7) (7), 3625 - 3635Scientific journal
- (株)日本臨床社, May 2024, 日本臨床, 82(増刊3 食道癌2024) (増刊3 食道癌2024), 532 - 536, Japanese
- Abstract Background Due to the coronavirus disease 2019 (COVID‐19) pandemic, cancer screening, diagnosis, and treatment have changed. This study aimed to investigate the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection prior to gastroenterological cancer surgeries on postoperative complications using data from a nationwide database in Japan. Methods Data on patients who underwent surgery for cancer including esophageal, gastric, colon, rectal, liver, and pancreatic cancer between July 1, 2019, and September 300, 2022, from real‐world sources in Japan were analyzed. The association between preoperative SARS‐CoV‐2 infection and short‐term postoperative outcomes was evaluated. A similar analysis stratified according to the interval from SARS‐CoV‐2 infection to surgery (<4 vs. >4 weeks) was conducted. Results In total, 60 604 patients were analyzed, and 227 (0.4%) patients were diagnosed with SARS‐CoV‐2 infection preoperatively. The median interval from SARS‐CoV‐2 infection to surgery was 25 days. Patients diagnosed with SARS‐CoV‐2 infection preoperatively had a significantly higher incidence of pneumonia (odds ratio: 2.05; 95% confidence interval: 1.05–3.74; p = 0.036) than those not diagnosed with SARS‐CoV‐2 infection based on the exact logistic regression analysis adjusted for the characteristics of the patients. A similar finding was observed in patients who had SARS‐CoV‐2 infection <4 weeks before surgery. Conclusions Patients with a history of SARS‐CoV‐2 infection had a significantly higher incidence of pneumonia. This finding can be particularly valuable for countries that have implemented strict regulations in response to the COVID‐19 pandemic and have lower SARS‐CoV‐2 infection‐related mortality rates.Wiley, May 2024, Annals of Gastroenterological Surgery, 8(5) (5), 942 - 951Scientific journal
- Elsevier BV, May 2024, The American Journal of Pathology, 194(5) (5), 828 - 848Scientific journal
- Abstract Background Although curative resection with vascular reconstruction improves the prognosis of blood‐invading locally advanced hepatobiliary tumors, the mortality and morbidity of the procedure remains unclear. This study aimed to clarify the risk factors associated with mortality and morbidity in patients undergoing liver resection with vascular reconstruction. Methods This retrospective observational study included 1215 patients undergoing hepatectomy of more than one section with vascular reconstruction, except for left lateral sectionectomy registered in the National Clinical Database (NCD) between 2015 and 2019. The rates of surgical mortality and relevant clinical factors were evaluated. Results Among the four types of vascular reconstruction, portal venous reconstruction was frequently performed in 724 patients (59.6% of the enrolled patients). Surgical mortality was 8.1%. Patients with hepatic artery reconstruction had the highest surgical mortality rate of 15.8%. In other types of reconstruction, surgical mortality was 9.1% in the portal vein, 5.2% in inferior vena cava, and 4.9% in hepatic vein. Factors significantly associated with surgical mortality include age, sex (male), preoperative comorbidity (American Society of Anesthesiologists grade >3, respiratory distress, diabetes, preoperative pneumonia, weight loss, and obstructive jaundice), poorer liver functional reserve (indocyanine green retention rate at 15 min and prothrombin time/international normalized ratio >1.1) and accompanying biliary reconstruction. Conclusions The NCD revealed the detailed status of liver resection combined with vascular reconstruction in Japan. Based on the results of this analysis, understanding the factors that influence the outcome and postoperative course of each procedure will provide patients with accurate information and opportunities to improve future outcomes.Wiley, Apr. 2024, Journal of Hepato-Biliary-Pancreatic Sciences, 31(7) (7), 425 - 436Scientific journal
- Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.Public Library of Science (PLoS), Apr. 2024, PLOS ONE, 19(4) (4), e0299742 - e0299742Scientific journal
- Abstract Aim We evaluated the morbidity and mortality associated with liver surgery in Japan and developed a risk model for liver resection using information from a national database. Methods We retrospectively reviewed 73 861 Japanese patients who underwent hepatectomy between 2014 and 2019, using information from the National Clinical Database (NCD) registrations. The primary endpoints were 30 days and in‐hospital mortality, and the secondary endpoints were postoperative complications. Logistic regression risk models for postoperative morbidity and mortality after hepatectomy were constructed based on preoperative clinical parameters and types of liver resection, and validated using a bootstrapping method. Results The 30‐day and in‐hospital mortality rates were 0.9% and 1.7%, respectively. Trisectionectomy, hepatectomy for gallbladder cancer, hepatectomy for perihilar cholangiocarcinoma, and poor activities of daily living were statistically significant risk factors with high odds ratios for both postoperative morbidity and mortality. Internal validations indicated that the c‐indices for 30‐day and in‐hospital mortality were 0.824 and 0.839, respectively. Conclusions We developed a risk model for liver resection by using a national surgical database that can predict morbidity and mortality based on preoperative factors.Wiley, Apr. 2024, Annals of Gastroenterological Surgery, 8(5) (5), 896 - 916Scientific journal
- Abstract Aim To examine the potential negative effects of the COVID‐19 pandemic on short‐term postoperative outcomes of emergency surgery for gastroduodenal perforation in Japan. Methods A total of 7973 cases of gastroduodenal perforation from 2019 to 2021 were retrieved from the National Clinical Database (NCD), which includes >95% of surgical cases in Japan. Data were analyzed nationally and in subgroups for subjects in areas with high infection levels (HILs). Postoperative 30‐d mortality, surgical mortality, and complications (Clavien–Dindo (CD) grade ≥3) were examined. Months were considered to have significantly high or low mortality or complication rates, if the 95% confidence interval (CI) of the standardized mortality (morbidity) ratio (SMR) does not contain 1. Results Nationally, data from 2019 vs 2020 and 2021 showed 30‐d mortality of 175 (6.7%) vs 398 (7.4%), surgical mortality of 250 (9.5%) vs 537 (10.1%), and complications (CD ≥3) of 558 (21.2%) vs 1163 (21.8%). Among these data, the only significantly high SMR was found for complications in July 2020 (1.36 [95% CI: 1.001–1.80]). In areas with HILs, data from 2019 vs 2020 and 2021 indicated 30‐d mortality of 91 (6.3%) vs 215 (7.3%), surgical mortality of 135 (9.4%) vs 294 (10.0%), and complications (CD ≥3) of 304 (21.1%) vs (23.1%). In these data, no month had a significantly high SMR. Conclusion The COVID‐19 pandemic had few negative effects on outcomes after surgery for gastroduodenal perforation. These findings suggest that the emergency system for gastroduodenal perforation in Japan was generally maintained during the pandemic.Wiley, Apr. 2024, Annals of Gastroenterological Surgery, 8(5) (5), 795 - 806Scientific journal
- Abstract Aim The existing predictive risk models for the surgical outcome of acute diffused peritonitis (ADP) need renovation by adding relevant variables such as ADP's definition or causative etiology to pursue outstanding data collection reflecting the real world. We aimed to revise the risk models predicting mortality and morbidities of ADP using the latest Japanese Nationwide Clinical Database (NCD) variable set. Methods Clinical dataset of ADP patients who underwent surgery, and registered in the NCD between 2016 and 2019, were used to develop a risk model for surgical outcomes. The primary outcome was perioperative mortality. Results After data cleanup, 45 379 surgical cases for ADP were derived for analysis. The perioperative and 30‐day mortality were 10.6% and 7.2%, respectively. The prediction models have been created for the mortality and 10 morbidities associated with the mortality. The top five relevant predictors for perioperative mortality were age >80, advanced cancer with multiple metastases, platelet count of <50 000/mL, serum albumin of <2.0 g/dL, and unknown ADP site. The C‐indices of perioperative and 30‐day mortality were 0.859 and 0.857, respectively. The predicted value calculated with the risk models for mortality was highly fitted with the actual probability from the lower to the higher risk groups. Conclusions Risk models for postoperative mortality and morbidities with good predictive performance and reliability were revised and validated using the recent real‐world clinical dataset. These models help to predict ADP surgical outcomes accurately and are available for clinical settings.Wiley, Apr. 2024, Annals of Gastroenterological Surgery, 8(4) (4), 711 - 727Scientific journal
- 金原出版(株), Apr. 2024, 手術, 78(5) (5), 769 - 775, Japanese
- Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory cancers with the worst prognosis. Although several molecules are known to be associated with the progression of PDAC, the molecular mechanisms underlying the progression of PDAC remain largely elusive. The Ror‐family receptors, Ror1 and Ror2, which act as a receptor(s) for Wnt‐family ligands, particularly Wnt5a, are involved in the progression of various types of cancers. Here, we show that higher expression of Ror1 and Wnt5b, but not Ror2, are associated with poorer prognosis of PDAC patients, and that Ror1 and Wnt5b are expressed highly in a type of PDAC cell lines, PANC‐1 cells. Knockdown of either Ror1 or Wnt5b in PANC‐1 cells inhibited their proliferation significantly in vitro, and knockout of Ror1 in PANC‐1 cells resulted in a significant inhibition of tumor growth in vivo. Furthermore, we show that Wnt5b‐Ror1 signaling in PANC‐1 cells promotes their proliferation in a cell‐autonomous manner by modulating our experimental setting in vitro. Collectively, these findings indicate that Wnt5b‐Ror1 signaling might play an important role in the progression of some if not all of PDAC by promoting proliferation.Wiley, Mar. 2024, Genes to CellsScientific journal
- Abstract Aim The coronavirus disease 2019 (COVID‐19) pandemic greatly impacted medical resources such as cancer screening, diagnosis, and treatment given to people for various diseases. We surveyed the impacts of the pandemic on the incidence of complications and mortality following pancreaticoduodenectomy for pancreatic cancer in Japan. Methods Data on patients who underwent pancreaticoduodenectomy for pancreatic cancer were extracted from the Japanese National Clinical Database (NCD) between 2018 and 2021. The number of the pancreaticoduodenectomy for pancreatic cancer were obtained and then the morbidity and mortality rates were evaluated using a standardized morbidity/mortality ratio (SMR), which is the ratio of the observed number of incidences to the expected number of incidences calculated by the risk calculator previously developed by the NCD. Results This study included 22 255 cases. The number of pancreaticoduodenectomies exhibited an increasing trend even during the COVID‐19 pandemic. The mean observed incidence rates of Grade C pancreatic fistula and Clavien–Dindo grade ≥4 complications, and the 30‐day mortality and surgical mortality rates were 0.8%, 1.8%, 0.8% and 0.9%, respectively. The standardized morbidity ratios did not increase during the COVID‐19 pandemic. The standardized mortality ratios remained within the range of variations observed before the COVID‐19 pandemic. Conclusion The increasing trend in the number of pancreaticoduodenectomies and favorable short‐term outcomes even in the COVID‐19 pandemic suggest the medical care for pancreatic cancer in Japan functioned well during the pandemic.Wiley, Mar. 2024, Annals of Gastroenterological Surgery, 8(5) (5), 877 - 887Scientific journal
- Mar. 2024, 日本コンピュータ外科学会誌, 25(4) (4), 273コンピュータ外科学の進歩
- Mar. 2024, 日本外科学会雑誌, 125(2) (2), 96外科医労働環境改善委員会の活動
- Springer Science and Business Media LLC, Feb. 2024, Surgery TodayScientific journal
- Abstract Aim The coronavirus disease 2019 (COVID‐19) pandemic has significantly impacted the allocation of medical resources, including cancer screening, diagnosis, and treatment. We aimed to investigate the effects of the pandemic on morbidity and mortality following hepatectomy for hepatocellular carcinoma (HCC). Methods We identified patients who underwent hepatectomy for HCC between 2018 and 2021 from the Japanese National Clinical Database (NCD). The number of surgical cases, the use of intensive care units, and the incidence of morbidity were assessed. The standardized morbidity / mortality ratio (SMR) was used to evaluate the rates of morbidity (bile leakage and pneumonia) and mortality in each month, which compares the observed incidence to the expected incidence calculated by the NCD's risk calculator. Results The study included a total of 10 647 cases. The number of patients undergoing hepatectomy for HCC gradually decreased. The proportion of patients aged 80 years or older increased and that of cases with T1 stage decreased. The proportion of patients who were admitted to the intensive care unit did not change between the pre‐ and postpandemic period. The mean actual incidence rates of bile leakage, pneumonia, 30‐day mortality, and surgical mortality were 9.2%, 2.3%, 1.4%, and 2.1%, respectively. The SMR for the mortalities and morbidities in each month did not increase mostly throughout the COVID‐19 pandemic. Conclusions The present study showed the decreasing number of resected cases for HCC, while the surgical safety for hepatectomy was enough to be maintained by managing medical resources in Japan.Wiley, Feb. 2024, Hepatology ResearchScientific journal
- (一社)日本消化器外科学会, Feb. 2024, 日本消化器外科学会雑誌, 57(2) (2), 51 - 59, Japanese
- (一社)日本消化器外科学会, Feb. 2024, 日本消化器外科学会雑誌, 57(2) (2), 67 - 74, Japanese
- (株)南江堂, Feb. 2024, 外科, 86(2) (2), 127 - 132, Japanese
- (株)南江堂, Feb. 2024, 外科, 86(2) (2), 127 - 132, Japanese
- Abstract Background Overall survival is considered as one of the most important endpoints of treatment efficacy but often requires long follow-up. This study aimed to determine the validity of recurrence-free survival as a surrogate endpoint for overall survival in patients with surgically resectable advanced oesophageal squamous cell carcinoma (OSCC). Methods Patients with OSCC who received neoadjuvant cisplatin and 5-fluorouracil, or docetaxel, cisplatin and 5-fluorouracil, at 58 Japanese oesophageal centres certified by the Japan Esophageal Society were reviewed retrospectively. The correlation between recurrence-free and overall survival was assessed using Kendall's τ. Results The study included 3154 patients. The 5-year overall and recurrence-free survival rates were 56.6 and 47.7% respectively. The primary analysis revealed a strong correlation between recurrence-free and overall survival (Kendall's τ 0.797, 95% c.i. 0.782 to 0.812) at the individual level. Subgroup analysis showed a positive relationship between a more favourable pathological response to neoadjuvant chemotherapy and a higher τ value. In the meta-regression model, the adjusted R2 value at the institutional level was 100 (95% c.i. 40.2 to 100)%. The surrogate threshold effect was 0.703. Conclusion There was a strong correlation between recurrence-free and overall survival in patients with surgically resectable OSCC who underwent neoadjuvant chemotherapy, and this was more pronounced in patients with a better response to neoadjuvant chemotherapy.Oxford University Press (OUP), Jan. 2024, British Journal of Surgery, 111(2) (2)Scientific journal
- Abstract Background The COVID‐19 outbreak made conventional medical care impossible, forcing changes in both healthcare providers and patients. In Japan, COVID‐19 infection began spreading in earnest in 2020 and exploded in 2021. There was concern that the medical impact of COVID‐19 in 2021 would differ from that in 2020. We aimed to clarify the impact of COVID‐19 on mortality and anastomotic leakage in laparoscopic surgery for gastric cancer and rectal cancer in Japan using the National Clinical Database (NCD). Methods We collected data from patients who underwent laparoscopic distal gastrectomy (LDG) and laparoscopic low anterior resection (LLAR) from January 2018 to December 2021 from the NCD, a web‐based surgical registration system in Japan. The number of surgical cases, monthly incidence of mortality and morbidity (anastomotic leakage), standardized mortality ratio (SMR), and standardized morbidity‐leakage ratio (SMLR [ratio of observed patients to expected patients calculated using the risk calculator established in the NCD]) were evaluated. Results The numbers of LDG and LLAR cases continued to decline in the first year of the pandemic in 2020 and were as low in 2021 as in 2020. Although the numbers of robot‐assisted LDG and LLAR cases increased, the growth rate was lower than the rate of increase prior to the pandemic. Mortality and anastomotic leakage, two of the most important complications, as assessed by SMR and SMLR, did not worsen during the pandemic in comparison to the pre‐pandemic period. Conclusions Laparoscopic surgeries were performed safely in Japan and were not affected by the COVID‐19 pandemic.Wiley, Jan. 2024, Annals of Gastroenterological Surgery, 8(3) (3), 521 - 529Scientific journal
- Springer Science and Business Media LLC, Jan. 2024, Langenbeck's Archives of Surgery, 409(1) (1)Scientific journal
- Abstract Background Anemia has negative effects on long‐term outcomes of rectal cancer patients; however, its status as a risk factor for severe complications is disputed. Perioperative risks may differ based on the severity of pre‐surgical anemia; nonetheless, no previous study has investigated these differences. This study identified risks of severe postoperative complications in rectal cancer patients based on severity of their pre‐surgical anemia. Materials and Methods This study enrolled patients who underwent low anterior resection for rectal cancer and were registered in the Japanese National Clinical Database (NCD) between 2017 and 2019. Anemia severity was categorized into three levels: mild, moderate, and severe. A logistic regression model was applied to calculate the risk‐adjusted odds ratio (OR) of severe complications after surgery. Results This study analyzed a cohort of 51 765 rectal cancer patients who underwent low anterior resection. Results showed that severe complications occurred in 10.9% of patients and were significantly more frequent in patients with anemia (13.6%) than those with normal hemoglobin levels (9.2%). Risk‐adjusted ORs of severe complications in the severe, moderate, and mild anemia groups versus the normal group for males were 1.19 (95% confidence interval [CI]: 0.89–1.58), 1.47 (1.34–1.62), and 1.21 (1.12–1.31), respectively. Those for females were 1.39 (0.90–2.15), 1.64 (1.37–1.97), and 1.36 (1.16–1.58), respectively. Conclusions According to this large cohort study, pre‐surgical anemia significantly increases the risk of severe postoperative complications in rectal cancer patients. Even mild anemia presents a significant risk.Wiley, Jan. 2024, Annals of Gastroenterological Surgery, 8(3) (3), 471 - 480Scientific journal
- Background/Aim: The relationship between gastric cancer and oral health has been reported in several studies. This study aimed to determine the relationship between the postoperative prognosis of gastric cancer and oral health using preoperative tooth loss as a simple index. Patients and Methods: We conducted a single-center retrospective cohort study. Patients were divided into two groups according to the number of tooth losses. The survival curve was constructed using the Kaplan–Meier method. We also performed univariate and multivariate analyses of overall survival based on Cox proportional hazard regression to determine prognostic factors. Results: A total of 191 patients were divided into two groups: those with seven or more tooth losses and those with less than seven tooth losses. The three-year overall survival rate was 71.5% in the group with seven or more tooth losses and 87.0% in the group with less than seven tooth losses. The group with seven or more tooth losses had a significantly lower overall survival rate compared to the group with less than seven tooth losses (p=0.0014). However, in multivariate analysis, tooth loss was not identified as an independent prognostic factor whereas age, clinical T stage, CEA level, and serum albumin level were independent poor prognostic factors. Conclusion: Preoperative tooth loss was not a prognostic factor for gastric cancer after gastrectomy, but tooth loss may be a simple and useful method for evaluating frailty in patients.Anticancer Research USA Inc., Jan. 2024, Cancer Diagnosis & Prognosis, 4(1) (1), 51 - 56Scientific journal
- (株)医学書院, Jan. 2024, 臨床外科, 79(1) (1), 44 - 47, Japanese
- (株)日本臨床社, Jan. 2024, 日本臨床, 82(増刊1 ロボット支援手術) (増刊1 ロボット支援手術), 163 - 169, Japanese
- Anticancer Research USA Inc., Dec. 2023, Anticancer Research, 44(1) (1), 229 - 237Scientific journal
- Springer Science and Business Media LLC, Dec. 2023, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489Scientific journal
- Springer Science and Business Media LLC, Dec. 2023, Surgery TodayScientific journal
- (株)癌と化学療法社, Dec. 2023, 癌と化学療法, 50(13) (13), 1370 - 1373, Japanese
- (株)癌と化学療法社, Dec. 2023, 癌と化学療法, 50(13) (13), 1374 - 1377, Japanese
- Lead, Dec. 2023, 日本消化管学会雑誌, 7(1) (1), 43 - 51消化管腫瘍の新展開 2021~2023
- Anticancer Research USA Inc., Nov. 2023, Anticancer Research, 43(12) (12), 5649 - 5656Scientific journal
- Springer Science and Business Media LLC, Nov. 2023, Esophagus, 21(1) (1), 2 - 10Scientific journal
- Abstract Aim Possible negative effects of the COVID‐19 pandemic on short‐term postoperative outcomes for colorectal perforation in Japan were examined in this study. Methods The National Clinical Database (NCD) is a large‐scale database including more than 95% of surgical cases in Japan. We analyzed 13 107 cases of colorectal perforation from 2019 to 2021. National data were analyzed, and subgroup analyses were conducted for subjects in prefectures with high infection levels (HILs) and metropolitan areas (Tokyo Met. and Osaka Pref.). Postoperative 30‐day mortality, surgical mortality, and postoperative complications (Clavien–Dindo grade ≥3) were examined. Months were considered to have significantly high or low mortality or complication rates, if the 95% confidence interval (CI) of the standardized mortality (morbidity) ratio (SMR) does not contain 1. Results In the NCD, postoperative 30‐day mortality occurred in 1371 subjects (10.5%), surgical mortality in 1805 (13.8%), and postoperative complications in 3950 (30.1%). Significantly higher SMRs were found for 30‐day mortality in November 2020 (14.6%, 1.39 [95% CI: 1.04–1.83]) and February 2021 (14.6%, 1.48 [95% CI: 1.10–1.96]), and for postoperative complications in June 2020 (37.3%, 1.28 [95% CI: 1.08–1.52]) and November 2020 (36.4%, 1.21 [95% CI: 1.01–1.44]). The SMRs for surgical mortality were not significantly high in any month. In prefectures with HILs and large metropolitan areas, there were few months with significantly higher SMRs. Conclusions The COVID‐19 pandemic had limited negative effects on postoperative outcomes in patients with colorectal perforation. These findings suggest that the emergency system for colorectal perforation in Japan was generally maintained during the pandemic.Wiley, Nov. 2023, Annals of Gastroenterological Surgery, 8(3) (3), 450 - 463Scientific journal
- Springer Science and Business Media LLC, Nov. 2023, Surgery Today, 54(5) (5), 459 - 470Scientific journal
- Tumor-associated macrophages (TAMs), one of the major components of the tumor microenvironment, contribute to the progression of esophageal squamous cell carcinoma (ESCC). We previously established a direct co-culture system of human ESCC cells and macrophages and reported the promotion of malignant phenotypes, such as survival, growth, and migration, in ESCC cells. These findings suggested that direct interactions between cancer cells and macrophages contribute to the malignancy of ESCC, but its underlying mechanisms remain unclear. In this study, we compared the expression levels of the interferon-induced genes between mono- and co-cultured ESCC cells using a cDNA microarray and found that interferon-inducible protein 16 (IFI16) was most significantly upregulated in co-cultured ESCC cells. IFI16 knockdown suppressed malignant phenotypes and also decreased the secretion of interleukin-1α (IL-1α) from ESCC cells. Additionally, recombinant IL-1α enhanced malignant phenotypes of ESCC cells through the Erk and NF-κB signaling. Immunohistochemistry revealed that high IFI16 expression in human ESCC tissues tended to be associated with disease-free survival and was significantly associated with tumor depth, lymph node metastasis, and macrophage infiltration. The results of this study reveal that IFI16 is involved in ESCC progression via IL-1α and imply the potential of IFI16 as a novel prognostic factor for ESCC.MDPI AG, Nov. 2023, Cells, 12(22) (22), 2603 - 2603Scientific journal
- Abstract Aim We explored institutional factors in Japan associated with lower operative mortality and failure‐to‐rescue (FTR) rates for eight major gastrointestinal procedures. Methods A 22‐item online questionnaire was sent to 2119 institutional departments (IDs) to examine the association between institutional factors and operative mortality and FTR rates. IDs were classified according to the number of annual surgeries, board certification status, and locality. In addition, the top 20% and bottom 20% of IDs were identified based on FTR rates and matched with the results of the questionnaire survey. Factors associated with operative mortality were selected by multivariate analysis. Results Of the 1083 IDs that responded to the questionnaire, 568 (213 382 patients) were included in the analysis. Operative morbidity, operative mortality, and FTR rates in the top 20% and bottom 20% of IDs were 13.1% and 8.4% (p < 0.001), 0.52% and 4.3% (p < 0.001), and 4.0% and 51.2% (p < 0.001), respectively. Based on the patients' background characteristics, the top 20% of IDs handled more advanced cases. No significant difference in locality was seen between better or worse hospital FTR rates, but fewer esophagectomies, hepatectomies, and pancreatoduodenectomies were performed in depopulated areas. Six items were found to be associated with operative mortality by multivariate logistic analysis. Only 50 (8.8%) IDs met all five factors related to better FTR rates. Conclusions The present findings indicate that several hospital factors surrounding surgical treatment, characterized by abundant human resources, are closely related to better postoperative recovery from severe complications.Wiley, Oct. 2023, Annals of Gastroenterological Surgery, 8(2) (2), 342 - 355Scientific journal
- Abstract There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.Springer Science and Business Media LLC, Oct. 2023, Scientific Reports, 13(1) (1)Scientific journal
- Oct. 2023, 臨床外科, 78(10) (10), 1272 - 1276医学生に対する外科勧誘のアプローチ
- Abstract Background The aim of this study was to analyze the nationwide surgical outcome of a left trisectionectomy (LT) and to identify the perioperative risk factors associated with its morbidity. Methods Cases of LT for hepato‐biliary malignancies registered at the Japanese National Clinical Database between 2013 and 2019 were retrospectively reviewed. Statistical analyses were performed to identify the perioperative risk factors associated with a morbidity of Clavien–Dindo classification (CD) ≥III. Results Left trisectionectomy was performed on 473 and 238 cases of biliary and nonbiliary cancers, respectively. Morbidity of CD ≥III and V occurred in 45% and 5% of cases with biliary cancer, respectively, compared with 26% and 2% of cases with nonbiliary cancer, respectively. In multivariable analyses, biliary cancer was significantly associated with a morbidity of CD ≥III (odds ratio, 1.87; p = .018). In subgroup analyses for biliary cancer, classification of American Society of Anesthesiologists physical status (ASA‐PS) 2, portal vein resection (PVR), and intraoperative blood loss ≥30 mL/kg were significantly associated with a morbidity of CD ≥III. Conclusions Biliary cancer induces severe morbidity after LT. The ASA‐PS classification, PVR, and intraoperative blood loss indicate severe morbidity after LT for biliary cancer.Wiley, Sep. 2023, Journal of Hepato-Biliary-Pancreatic Sciences, 30(12) (12), 1304 - 1315Scientific journal
- BACKGROUND: There are few studies on the impact of a colorectal-specific technically certified surgeon on good surgical outcomes for laparoscopic low anterior resection in the real world. OBJECTIVE: To evaluate the short-term outcomes of laparoscopic low anterior resection with the participation of a certified colorectal surgeon. DESIGN: This was a retrospective cohort study using a Japanese nationwide database. SETTING: This study was conducted as a project for the Japan Society of Endoscopic Surgery and the Japanese Society of Gastroenterological Surgery. PATIENTS: This study included 41,741 patients listed in the National Clinical Database who underwent laparoscopic low anterior resection performed by certified, noncertified, and colorectal-specific certified surgeons, according to the Endoscopic Surgical Skill Qualification System, from 2016 to 2018. MAIN OUTCOME MEASURES: Operative mortality rate and anastomotic leak rate were the primary outcome measures. RESULTS: Overall 30-day mortality and operative mortality were 0.2% and 0.3%, respectively, without significant differences between all kinds of certified and noncertified surgeon groups. Overall anastomotic leak rate was 9.3%, with a significant difference between the 2 groups. Colorectal- and stomach-certified groups had lower 30-day mortality and operative mortality than the biliary-certified and noncertified groups. The anastomotic leak rate was the lowest in the colorectal-certified group. Based on a logistic regression analysis using the risk-adjusted model, operative mortality was significantly higher in the biliary-certified group than in the colorectal-certified group. Moreover, anastomotic leak rate was significantly lower in the colorectal-certified group than in the stomach-certified and noncertified groups. LIMITATIONS: This study was a retrospective study, and there was a possibility of different definitions of anastomotic leak due to the use of a nationwide database. CONCLUSIONS: The participation of a colorectal-specific certified surgeon may decrease the risk of operative mortality and anastomotic leak for laparoscopic low anterior resection. CIRUJANO COLORRECTAL ALTAMENTE CALIFICADO PROVOCA RESULTADOS QUIRÚRGICOS FAVORABLES A CORTO PLAZO PARA LA RESECCIÓN ANTERIOR BAJA LAPAROSCÓPICA: EVALUACIÓN DE LA BASE DE DATOS NACIONAL JAPONESA ANTECEDENTES: Hay pocos estudios sobre el impacto de un cirujano certificado técnicamente especializado en cáncer colorrectal con un buen resultado quirúrgico para la resección anterior baja laparoscópica en el mundo real. OBJETIVO: Evaluar los resultados a corto plazo de la resección anterior baja laparoscópica con la participación de un cirujano colorrectal certificado. DISEÑO: Este fue un estudio de cohorte retrospectivo que utilizó una base de datos nacional japonesa. AJUSTE: Este estudio se realizó como un proyecto para la Sociedad Japonesa de Cirugía Endoscópica y la Sociedad Japonesa de Cirugía Gastroenterológica. PACIENTES: este estudio incluyó a 41 741 pacientes incluidos en la base de datos clínica nacional que se sometieron a una resección anterior baja laparoscópica realizada por cirujanos certificados, no certificados y certificados específicamente colorrectales, según el Sistema de calificación de habilidades quirúrgicas endoscópicas de 2016 a 2018. PRINCIPALES MEDIDAS DE RESULTADO: La tasa de mortalidad operatoria y la tasa de fuga anastomótica fueron los resultados primarios. RESULTADOS: La mortalidad general a los 30 días y la mortalidad operatoria fueron del 0,2 % y el 0,3 %, respectivamente, sin diferencias significativas entre los grupos de todos los tipos de cirujanos certificados y no certificados. La tasa global de fuga anastomótica fue del 9,3 %, con una diferencia significativa entre los dos grupos. Los grupos con certificación colorrectal y estomacal tuvieron una mortalidad a los 30 días y una mortalidad operatoria más bajas que los grupos con certificación biliar y sin certificación. La tasa de fuga anastomótica fue la más baja en el grupo certificado colorrectal. Con base en un análisis de regresión logística utilizando el modelo ajustado por riesgo, la mortalidad operatoria fue significativamente más alta en el grupo con certificación biliar que en el grupo con certificación colorrectal. Además, la tasa de fuga anastomótica fue significativamente más baja en el grupo con certificación colorrectal que en los grupos con certificación estomacal y sin certificación. LIMITACIONES: Este estudio fue retrospectivo y existía la posibilidad de diferentes definiciones de fuga anastomótica debido al uso de una base de datos nacional. CONCLUSIONES: La participación de un cirujano certificado en video específico colorrectal puede disminuir el riesgo de mortalidad operatoria y fuga anastomótica para la resección anterior baja laparoscópica. (Traducción—Dr. Mauricio Santamaria)Ovid Technologies (Wolters Kluwer Health), Sep. 2023, Diseases of the Colon & Rectum, 66(12) (12), e1217 - e1224Scientific journal
- Sep. 2023, 癌と化学療法, 50(9) (9), 955 - 957【免疫療法を支える基礎研究】深層学習アルゴリズムを基盤としたイメージングサイトメトリーによる大腸癌腫瘍免疫微小環境の解析
- Abstract Aim The Coronavirus Disease 2019 (COVID‐19) pandemic affected the allocation of various medical resources to several areas, including intensive care units (ICUs). However, currently, its impact on the short‐term postoperative outcomes of gastrointestinal cancer surgeries remains unclear. We aimed to evaluate the impact of the pandemic on the incidence of complications occurring after low anterior resection in patients with rectal cancer in Japan. Methods Data from the Japanese National Clinical Database between 2018 and 2021 were retrospectively examined. The primary outcome of the study was the postoperative morbidity and mortality rates before and after COVID‐19 pandemic. Moreover, the postoperative ICU admission rate was assessed. Morbidity and mortality rates were also assessed using a standardized morbidity/mortality ratio (SMR, the ratio of the actual number of incidences to the expected number of incidences calculated by the risk calculator). Results This study included 74 181 patients, including 43 663 (58.9%) from COVID‐19 epidemic areas. The mean actual incidences of anastomotic leakage (AL) and pneumonia during the study period were 9.2% and 0.9%, respectively. The SMRs of these complications did not increase during the pandemic but those of AL declined gradually. The mean 30‐day mortality and operative mortality rates were 0.3% and 0.5%, respectively. Moreover, SMRs did not change significantly in the pandemic or regional epidemic status. The ICU admission rate temporarily decreased, especially in the epidemic areas. Conclusion Although the pandemic temporarily decreased the ICU admission rate, its impact on short‐term outcomes following low anterior resection in patients with rectal cancer was insignificant in Japan.Wiley, Aug. 2023, Annals of Gastroenterological Surgery, 8(1) (1), 107 - 113Scientific journal
- Wiley, Aug. 2023, Annals of Gastroenterological Surgery, 7(5) (5), 694 - 695Scientific journal
- PURPOSE: A phase III trial comparing S-1 and docetaxel with S-1 alone as postoperative chemotherapy for pathologically Stage III gastric cancer was conducted and clarified the superiority of the doublet in terms of 3-year relapse-free survival as the primary endpoint (67.7% versus 57.4%, hazard ratio [HR] 0.715, 95% confidence interval [CI] 0.587-0.871; p = 0.0008). This final report analyzed 5-year survival outcomes along with the incidence and pattern of late recurrences. PATIENTS AND METHODS: Patients with histologically confirmed Stage III gastric cancer who underwent gastrectomy with D2 lymphadenectomy were randomly assigned to receive adjuvant chemotherapy with either S-1 plus docetaxel or S-1 alone. The same 912 patients who were evaluated for 3-year survival outcomes in the previous report were analyzed. RESULTS: Five-year overall survival rate of the S-1 plus docetaxel group (67.91%) was significantly superior to that in the S-1 group (60.27%; HR 0.752, 95% CI 0.613-0.922; p = 0.0059). The incidence of late recurrence at > 3 years after randomization was similar in both groups (7.3% versus 7.2%). Peritoneal dissemination was the most common pattern of late recurrence. Addition of docetaxel significantly suppressed relapse through the lymphatic (6.8% [95% CI 4.52-9.17] versus 15% [95% CI 11.76-18.30]; p < 0.0001) and hematogenous (10.2% [95% CI 7.37-12.94] versus 15.7% [95% CI 12.36-19.01]; p < 0.0137) pathways throughout the 5 years of follow-up. CONCLUSION: The survival benefit of postoperative chemotherapy with S-1 and docetaxel in terms of 5-year overall survival rate was confirmed for patients with pathologically Stage III gastric cancer, although late recurrences were not prevented.Aug. 2023, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, English, Domestic magazineScientific journal
- OBJECTIVE: This study aimed to validate the prognostic significance of stratification using pathological stage and response to neoadjuvant chemotherapy with a nationwide database from an authorized institute by the Japan Esophageal Society. BACKGROUND: We proposed the combined criteria using pStage and pathological response. Conducting a validation study using an expanded cohort in the clinical setting would be valuable since it was developed using retrospective data collection. METHODS: Patients with esophageal squamous cell carcinoma who underwent subtotal esophagectomy at 85 authorized institutes were retrospectively reviewed for esophageal cancer between 2010 and 2015. The prognostic value of the pathological response was evaluated within the same pStage. Moreover, risk stratification was developed to predict cancer-specific survival (CSS). RESULTS: The pathological response showed significant stratification of CSS in 3761 patients included in this analysis. We classified the patients into 7 groups as survival was significantly different between responders and nonresponders under the stratification with pStage, excluding pStage I comprising pStage 0-I/II responder/II nonresponder/III responder/III nonresponder/IV responder/IV nonresponder with the 5-year CSS of 83.7%/75.8%/68.9%/59.8%/44.4%/40.7%/23.1%, respectively. Furthermore, the area under the curve was significantly higher under the new classification than in the pStage alone ( P <0.001). CONCLUSIONS: The prognostic value of classification using pStage and the pathological response was successfully validated using real-world data in Japan. This result would guide appropriate treatment for patients with esophageal squamous cell carcinoma who received neoadjuvant chemotherapy followed by esophagectomy.Aug. 2023, Annals of surgery, 278(2) (2), e234-e239, English, International magazineScientific journal
- Aug. 2023, Journal of the American College of Surgeons, 237(2) (2), 396 - 396, English, International magazine
- BACKGROUND/AIM: In pathology, the digitization of tissue slide images and the development of image analysis by deep learning have dramatically increased the amount of information obtainable from tissue slides. This advancement is anticipated to not only aid in pathological diagnosis, but also to enhance patient management. Deep learning-based image cytometry (DL-IC) is a technique that plays a pivotal role in this process, enabling cell identification and counting with precision. Accurate cell determination is essential when using this technique. Herein, we aimed to evaluate the performance of our DL-IC in cell identification. MATERIALS AND METHODS: Cu-Cyto, a DL-IC with a bit-pattern kernel-filtering algorithm designed to help avoid multi-counted cell determination, was developed and evaluated for performance using tumor tissue slide images with immunohistochemical staining (IHC). RESULTS: The performances of three versions of Cu-Cyto were evaluated according to their learning stages. In the early stage of learning, the F1 score for immunostained CD8+ T cells (0.343) was higher than the scores for non-immunostained cells [adenocarcinoma cells (0.040) and lymphocytes (0.002)]. As training and validation progressed, the F1 scores for all cells improved. In the latest stage of learning, the F1 scores for adenocarcinoma cells, lymphocytes, and CD8+ T cells were 0.589, 0.889, and 0.911, respectively. CONCLUSION: Cu-Cyto demonstrated good performance in cell determination. IHC can boost learning efficiencies in the early stages of learning. Its performance is expected to improve even further with continuous learning, and the DL-IC can contribute to the implementation of precision oncology.Aug. 2023, Anticancer research, 43(8) (8), 3755 - 3761, English, International magazineScientific journal
- BACKGROUND/AIM: Colorectal cancer (CRC) with reduced expression of the homeobox transcription factor CDX2, a master gene essential for the development and maintenance of the intestinal tract, is known as a poor prognosis subtype of CRC. The recurrence rate is high in patients with CDX2low CRC. However, the prognostic significance of CDX2 in advanced CRC is unclear. This study aimed to elucidate the prognostic significance of CDX2 in unresectable metastatic CRC (mCRC). PATIENTS AND METHODS: Twenty-nine patients with unresectable mCRC who underwent primary site resection at the Kobe University Hospital during a 6-year period from January 2008 to January 2015 were included. The tissues from those patients were immunohistochemically stained with anti-CDX2 antibody (clone: CDX2-88). The patients were divided into CDX2high CRC group and CDX2low CRC group and their prognoses were analyzed. RESULTS: There were no clear differences in background between the two groups. A low CDX2 expression was associated with reduced overall survival (37.67 months vs. 25.32 months, p=0.03) and tended to associate with reduced progression-free survival (17.4 months vs. 12.9 months, p=0.37). Two patients received chemotherapy after resection of the primary lesion and obtained pathological complete response. CONCLUSION: CDX2 expression might be a possible prognostic biomarker for unresectable mCRC.Aug. 2023, Anticancer research, 43(8) (8), 3763 - 3767, English, International magazineScientific journal
- PURPOSE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In recent years, the proportion of patients diagnosed with CRC at younger ages has increased. The clinicopathological features and oncological outcomes in younger patients with CRC remain controversial. We aimed to analyze the clinicopathological features and oncological outcomes in younger patients with CRC. METHODS: We examined 980 patients who underwent surgery for primary colorectal adenocarcinoma between 2006 and 2020. Patients were divided into two cohorts: younger (< 40 years old) and older (≥ 40 years old). RESULTS: Of the 980 patients, 26 (2.7%) were under the age of 40 years. The younger group had more advanced disease (57.7% vs. 36.6%, p = 0.031) and more cases beyond the transverse colon (84.6% vs. 65.3%, p = 0.029) than the older group. Adjuvant chemotherapy was administered more frequently in the younger group (50% vs. 25.8%, p < 0.01). Relapse-free survival and overall survival were similar between the groups at all stages. Moreover, in stages II and III they were also comparable, regardless of the administration of adjuvant chemotherapy. CONCLUSIONS: Younger patients with CRC have a prognosis equivalent to that of older patients. Further studies are needed to establish the optimal treatment strategies for these patients.Jul. 2023, International journal of colorectal disease, 38(1) (1), 191 - 191, English, International magazineScientific journal
- OBJECTIVE: We aimed to evaluate the efficacy of neoadjuvant docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy over cisplatin and 5-fluorouracil (CF) in patients with surgically resectable advanced esophageal squamous cell carcinoma (ESCC), using real-world data from 85 esophageal centers. BACKGROUND: JCOG1109 trial, which assessed the superiority of DCF over CF, and the superiority of chemoradiotherapy with CF over CF alone demonstrated the significant survival advantage of neoadjuvant DCF in overall survival (OS) over CF for ESCC. METHODS: The ESCC patients who received neoadjuvant CF or DCF at 85 Japanese esophageal centers certified by the Japan Esophageal Society were retrospectively reviewed. After propensity score (PS) matching, the OS and recurrence-free survival were compared between CF and DCF. RESULTS: We initially enrolled 4781 patients. After data cleaning and PS matching using pretreatment variables, 1074 patients for each group were selected for subsequent analysis. There was no significant difference in the incidence of postoperative pneumonia and anastomotic leakage. In the survival analysis, OS was significantly longer in DCF group than CF group (hazard ratio, 0.868; 95% confidence interval, 0.770-0.978; P =0.02), as well as recurrence-free survival (hazard ratio, 0.850; 95% confidence interval, 0.761-0.949; P =0.004). The survival advantage of DCF was not observed in patients with 76 years old or older. CONCLUSIONS: Neoadjuvant DCF therapy showed a remarkable survival advantage in surgically resectable ESCC patients, especially in patients who were 75 years old or younger. The current real-world evidence will encourage recommendations for DCF as a standard regimen in neoadjuvant chemotherapy-based treatment strategy for ESCC.Jul. 2023, Annals of surgery, 278(1) (1), e35-e42, English, International magazineScientific journal
- BACKGROUND: The prognostic impact of docetaxel, cisplatin, and 5-FU (DCF) reported in JCOG1109 was successfully validated using real-world data in patients < 75 years old. However, DCF was not reported to be beneficial in elderly patients with a relatively higher postoperative complication incidence. This study aimed to clarify the impact of postoperative complications on the prognosis of ESCC and the difference in the magnitude of the impact by age and regimen. METHODS: Patients with esophageal squamous cell carcinoma (ESCC) who underwent subtotal esophagectomy at 85 authorized institutes were retrospectively reviewed from 2010 to 2015. The prognostic impact of postoperative anastomotic leakage (AL) and pneumonia on survival was evaluated. The prognostic value of the postoperative complications was assessed by stratifying patients according to age and neoadjuvant chemotherapy regimen. RESULTS: Patients with AL, pneumonia, and infectious complications (ICs: a combination of pneumonia and AL) showed significantly worse overall survival (OS). IC served as a negative prognostic factor of OS and recurrence-free survival, and its negative prognostic impact was more evident in patients aged > 75 years. When the patients were further stratified by chemotherapeutic regimens, using the CF/IC(-) group as a reference, the DCF/IC (+) group showed significantly shorter OS in patients aged > 75 years with a hazard ratio (HR) of 2.551. The HR of the CF/IC (+) group was 1.503. CONCLUSIONS: The negative impact of postoperative complications on survival was confirmed in this nationwide study. Furthermore, its magnitude was higher in elderly patients who received triplet chemotherapy.Jul. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(3) (3), 445 - 454, English, Domestic magazineScientific journal
- BACKGROUND: Centralization of complex surgeries has made little progress when it only considers the minimum number of surgical procedures. We aim to assess the impact of certification system of Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS) on centralization and surgical quality of advanced hepato-pancreatic-biliary (HPB) surgery. METHODS: The National Clinical Database was used to review 20 111 patients who underwent pancreatoduodenectomy (PD) and 9666 who underwent advanced hepatectomy defined as hepatectomy of more than one section during 2019 and 2020. JSHPBS certifies hospitals based on the annual number of advanced HPB surgeries and the surgical quality. Minimum numbers of surgeries for board-certified A and B institutions are 50 and 30, respectively. Short-term outcomes were compared among institutions. RESULTS: In 2020, 69.4% (7007/10090) and 72.9% (3433/4710) of patients underwent PD and advanced hepatectomy at board-certified institutions. In-hospital mortality rates after PD was 0.9% at certified A institutions, 1.4% at B institutions, and 2.7% at non-certified institutions (p < .001). The odds ratio (OR) of risk-adjusted mortality after PD compared with non-certified institutions was 0.39 (confidence interval [CI]: 0.30-0.50, p < .001) at certified A institutions, and 0.54 at certified B institutions (CI: 0.40-0.73, p < .001). In-hospital mortality rates after advanced hepatectomy was 1.7% at certified A institutions, 2.3% at B institutions, and 3.2% at non-certified institutions (p < .001). The OR of risk-adjusted mortality after advanced hepatectomy compared with non-certified institutions was 0.57 at certified A institutions (CI: 0.41-0.78, p < .001). CONCLUSION: The volume- and quality-controlled certification system of JSHBPS reduces surgical mortality after advanced HPB surgeries.Jul. 2023, Journal of hepato-biliary-pancreatic sciences, 30(7) (7), 851 - 862, English, Domestic magazineScientific journal
- BACKGROUND: Cervical esophageal cancer accounts for a small proportion of all esophageal cancers. Therefore, studies examining this cancer include a small patient cohort. Most patients with cervical esophageal cancer undergo reconstruction using a gastric tube or free jejunum after esophagectomy. We examined the current status of postoperative morbidity and mortality of cervical esophageal cancer based on big data. METHODS: Based on the Japan National Clinical Database, 807 surgically treated patients with cervical esophageal cancer were enrolled between January 1, 2016, and December 31, 2019. Surgical outcomes were retrospectively reviewed for each reconstructed organ using gastric tubes and free jejunum. RESULTS: The incidence of postoperative complications related to reconstructed organs was higher in the gastric tube reconstruction (17.9%) than in the free jejunum (6.7%) for anastomotic leakage (p < 0.01), but not significantly different for reconstructed organ necrosis (0.4% and 0.3%, respectively). The incidence rates of overall morbidity, pneumonia, 30-day reoperation, tracheal necrosis, and 30-day mortality using these reconstruction methods were 64.7% and 59.7%, 16.7% and 11.1%, 9.3% and 11.4%, 2.2% and 1.6%, and 1.2% and 0.0%, respectively. Only pneumonia was more common in the gastric tube reconstruction group (p = 0.03), but was not significantly different for any other complication. CONCLUSIONS: The incidence of overall morbidities and reoperation, especially anastomotic leakage after gastric tube reconstruction, suggested a necessity for further improvement. However, the incidence of fatal complications, such as tracheal necrosis or reconstructed organ necrosis, was low for both reconstruction methods, and the mortality rate was acceptable as a means of radical treatment.Jul. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(3) (3), 427 - 434, English, Domestic magazineScientific journal
- BACKGROUND: Our previous study reported the prognostic significance of endoscopic response (ER) evaluation, defined ER, and revealed ER as an independent prognostic factor of overall survival (OS) and recurrence-free survival (RFS) for esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemotherapy (NAC) and surgery. The present study aimed to validate the prognostic impact of ER using a nationwide database from the authorized institute for board-certified esophageal surgeons by the Japan Esophageal Society. METHODS: This study retrospectively reviewed patients with ESCC who underwent subtotal esophagectomy at 85 authorized institutes for esophageal cancer from 2010 to 2015. Patients were classified as ER when the tumor size was markedly reduced post-NAC compared to pre-NAC. The correlation between OS and RFS was investigated. RESULTS: Of 4781 patients initially enrolled, 3636 were selected for subsequent analysis. Of them, 642 (17.7%) patients were classified as the ER group. Patients with ER showed significantly better OS and RFS. Subgroup analysis revealed the statistical difference in OS and RFS in cStage II and III, while the magnitude of survival difference between ER and non-ER was not evident in cStage I and IV. The percentage of ER varied from 46 to 87% among groups when institutions were classified into 3 subgroups based on the hospital volume, which would indicate the interinstitutional inconsistency. CONCLUSIONS: The prognostic impact of ER was validated using a nationwide database. Standardization of ER evaluation is required to improve the interinstitutional consistency and clinical validity of the ER evaluation.Jul. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(3) (3), 455 - 464, English, Domestic magazineScientific journal
- Jul. 2023, Annals of surgical oncology, 30(7) (7), 4056 - 4057, English, International magazineScientific journal
- BACKGROUND: Although neoadjuvant treatment (NAT) has become the standard of care for patients with locally advanced esophageal cancer, the risk of recurrence remains high. The risk must be predicted accurately, so that appropriate adjuvant therapy can be planned. We aimed to develop a model predicting recurrence of esophageal squamous cell carcinoma (ESCC) in patients who received NAT before esophagectomy. METHODS: This nationwide study included 3874 patients from 85 institutions. Patients who underwent NAT and then surgery for ESCC were eligible. We developed a Cox proportional hazards model and created a nomogram to predict disease recurrence after NAT and curative esophagectomy. RESULTS: Of the patients, 268 (6.9%), 1280 (33.0%), 2006 (51.8%), and 320 (8.3%) had clinical stage I, II, III, and IV tumors, respectively. The 5-year recurrence rate was 45.1% (95% confidence interval 43.4%-46.7%). Multivariable analysis revealed that body mass index, type of neoadjuvant treatment, primary tumor location, operative blood loss, pathological tumor stage, pathological therapeutic effect, and leakage were independently associated with disease recurrence. Using 13 commonly measured perioperative variables, we created a predictive nomogram, and the area under the curve was 0.783 (95% confidence interval 0.766-0.800). This nomogram was also adequately validated internally and had excellent calibration capacity (calibration slope, 0.992). CONCLUSIONS: The model developed in this study adequately predicted ESCC recurrence in patients who underwent NAT and then esophagectomy. Further research with this nomogram is needed to assess the effect of adjuvant therapy in patients at high risk for recurrence.Jul. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(3) (3), 465 - 473, English, Domestic magazineScientific journal
- BACKGROUND: Retrosternal reconstruction has lower risks for severe postoperative morbidities, such as gastro-tracheal fistula or esophageal hiatal hernia. We have previously reported the laparoscopic retrosternal route creation (LRRC) method, but its safety and efficacy remain unclear. METHODS: In total, 374 patients with esophageal carcinoma who underwent minimally invasive McKeown esophagectomy in the prone position between 2010 and 2021 were retrospectively reviewed. We performed a propensity score-matched analysis with the simple, nearest-neighbor method and no calipers to compare postoperative outcomes and reconstructed gastric conduit functionality between patients who underwent LRRC and counterparts who underwent posterior mediastinal reconstruction. RESULTS: After matching, 62 patients were included in the laparoscopic retrosternal group (LR group) or posterior mediastinal group (PM group). No significant differences were observed between the groups, apart from the number of robot-assisted surgeries, the extent of lymph node dissection, and the method of cervical anastomosis. There were no significant differences in the incidence of Clavien-Dindo grade ≥ 2 complications. Gastro-tracheal fistula (n = 1) and esophageal hiatal hernia (n = 2) occurred in the PM group but not in the LR group. There were no differences in the incidence of pulmonary embolism between the groups (5% vs. 5%). The postoperative anastomotic stenosis rate was similar (16% vs. 27%, p = 0.192). Endoscopic findings of reflux esophagitis (modified Los Angeles classification ≥ M) at 1 year after surgery were significantly better in the LR group (p = 0.037). CONCLUSIONS: LRRC for gastric conduit reconstruction is safe and valuable. It is associated with good reconstructed gastric conduit function.Jul. 2023, Annals of surgical oncology, 30(7) (7), 4044 - 4053, English, International magazineScientific journal
- BACKGROUND/AIM: There are several concerns about oncological contamination and technical difficulty in the laparoscopic approach for locally advanced gastric cancer. We aimed to determine the safety and usefulness of laparoscopic gastrectomy for patients with advanced gastric cancer with tumor depth greater than serosal invasion. PATIENTS AND METHODS: Sixty-two laparoscopic and 82 laparotomy gastric cancer cases surgically diagnosed as serosal or other organ invasions intraoperatively between 2011 and 2021 were included. The laparoscopic and open gastrectomy results were compared by propensity score matching using stage, preoperative chemotherapy, curative resection, surgical technique, and age as explanatory variables and laparoscopy and open resection as outcome variables. RESULTS: No difference in median operative time (341 vs. 386 minutes, p=0.24) was observed, but median blood loss (0 vs. 510 ml, p<0.001) and blood transfusion requirement (9.5 vs. 43%, p<0.001) were lower in the laparoscopic group. No difference was observed between the two groups regarding complications. Furthermore, 3-year overall survival was also similar (43 vs. 42%, p=0.74). CONCLUSION: The laparoscopic surgery results are comparable to those of open surgery in treating gastric cancer with T4a or greater depth. In addition, it is minimally invasive with less blood loss, making it a standard approach.Jul. 2023, Anticancer research, 43(7) (7), 3145 - 3152, English, International magazineScientific journal
- AIM: This study aimed to evaluate the impact of the coronavirus disease (COVID-19) pandemic on elective endoscopic surgeries in Japan using the National Clinical Database. METHODS: We retrospectively analyzed the clinicopathological factors and surgical outcomes of laparoscopic cholecystectomy (LC), laparoscopic distal gastrectomy (LDG), and laparoscopic low anterior resection (LLAR) and compared the monthly numbers of each procedure performed in 2020 with those in 2018 and 2019. The degree of infection in prefectures was classified into low and high groups. RESULTS: In 2020, the number of LCs (except for acute cholecystitis) was 76 079 (93.0% of that in 2019), the number of LDGs was 14 271 (85.9% of that in 2019), and the number of LLARs was 19 570 (88.1% of that in 2019). Although the number of robot-assisted LDG and LLAR cases increased in 2020, the growth rate was mild compared with that in 2019. There was little difference in the number of cases in the degree of infection in the prefectures. The numbers of LC, LDG, and LLAR cases decreased from May to June and recovered gradually. In late 2020, the proportion of T4 and N2 cases of gastric cancer and the number of T4 cases of rectal cancer increased compared with those in 2019. There was little difference between the proportions of postoperative complications and mortality in the three procedures between 2019 and 2020. CONCLUSION: The number of endoscopic surgeries decreased in 2020 as a result of the COVID-19 pandemic. However, the procedures were performed safely in Japan.Jul. 2023, Annals of gastroenterological surgery, 7(4) (4), 572 - 582, English, Domestic magazineScientific journal
- BACKGROUND: The effect of lymphadenectomy around the recurrent laryngeal nerve (RLN) in open oesophagectomy was demonstrated with the Efficacy Index (EI). However, it remains unclear whether this effect exists for minimally invasive esophagectomy (MIE) in the prone position. The purpose of this study is to clarify the upper mediastinal lymphadenectomy contributes to improved prognosis in patients with esophageal squamous cell carcinoma. STUDY DESIGN: This study included 339 patients with esophageal squamous cell carcinoma treated with MIE in the prone position at Kobe University or Hyogo Cancer Center from 2010 to 2015. EI for each station, correlations between metastatic L/Ns around the left RLN and RLN palsy, and survival of patients with and without upper mediastinal lymphadenectomy were investigated. RESULTS: Among 297 patients treated with upper mediastinal lymphadenectomy, Clavien- Dindo grade > II left RLN palsy occurred in 59 patients (20%). Overall, EIs for the right RLN (7.4) and left RLN (6.6) were higher than EIs for other stations. For patients with upper-third or middle-third tumors, the trend was stronger. Left RLN palsy was more likely in patients with metastatic L/Ns around the left RLN than in those without (44% vs. 15%, P < 0.0001).After propensity score-matching, 42 patients were included in each group with and without upper mediastinal lymphadenectomy. In survival analyses, the 5-year overall survival (OS) were 55% vs. 35% and cause-specific survival (CSS) rates were 61% vs. 43% for the patients with and without upper mediastinal lymphadenectomy respectively. Significant differences were confirmed in survival curves (OS; P = 0.03 and CSS; P = 0.04, respectively). CONCLUSIONS: Upper mediastinal lymphadenectomy contributes to improved prognosis with high EIs in MIE in the prone position.Jun. 2023, Journal of the American College of Surgeons, English, International magazineScientific journal
- BACKGROUND: Gastrectomy with D2 dissection and adjuvant chemotherapy is the standard treatment for locally advanced gastric cancer (LAGC) in Asia. However, administering chemotherapy with sufficient intensity after gastrectomy is challenging. Several trials demonstrated the efficacy of neoadjuvant chemotherapy (NAC). However, limited studies explored the feasibility of NAC-SOX for older patients with LAGC. This phase II study (KSCC1801) evaluated the safety and efficacy of NAC-SOX in patients with LAGC aged ≥ 70 years. METHODS: Patients received three cycles of SOX130 (oxaliplatin 130 mg/m2 on day 1, oral S-1 40-60 mg twice daily for two weeks every three weeks) as NAC, followed by gastrectomy with lymph node dissection. The primary endpoint was the dose intensity (DI). The secondary endpoints were safety, R0 resection rate, pathological response rate (pRR), overall survival, and relapse-free survival. RESULTS: The median age of 26 enrolled patients was 74.5 years. The median DI in NAC-SOX130 was 97.2% for S-1 and 98.3% for oxaliplatin. Three cycles of NAC were administered in 25 patients (96.2%), of whom 24 (92.3%) underwent gastrectomy with lymphadenectomy. The R0 resection rate was 92.3% and the pRR (≥ grade 1b) was 62.5%. The major adverse events (≥ grade 3) were neutropenia (20.0%), thrombocytopenia (11.5%), anorexia (11.5%), nausea (7.7%), and hyponatremia (7.7%). Postoperative complications of abdominal infection, elevated blood amylase, and bacteremia occurred in one patient each. Severe diarrhea and dehydration caused one treatment-related death. CONCLUSIONS: NAC-SOX130 is a feasible therapy for older patients, although systemic management and careful monitoring of adverse events are necessary.Jun. 2023, International journal of clinical oncology, English, Domestic magazineScientific journal
- BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic had adversely impacted cancer screening, diagnosis, and treatment. We investigated the change in medical resource, such as the intensive care unit use, and short-term outcomes after esophagectomy during the pandemic. METHODS: Data of patients who underwent esophagectomy for esophageal cancer registered in the National Clinical Database (NCD) in Japan from January 2018 to December 2021 were analyzed. The time series change in the number of surgical cases; usage of intensive care unit; incidence of morbidity and mortality; standardized mortality and morbidity ratio (SMR) for 30-days mortality; surgical mortality; and morbidities for pneumonia, sepsis, unplanned intubation, and anastomotic leakage were evaluated. RESULTS: The annual number of patients undergoing esophagectomy remained similar from 2018 to 2021. The negative impact of the pandemic on medical resources was strongly identified in the patients from an epidemic area where there is a higher cumulative number of infections per population as compared to all prefectures. The proportions of patients admitted to the intensive care unit were 91.4%, 93.0%, 91.6%, and 90.5% in 2018, 2019, 2020, and 2021, respectively. Moreover, 93.3%, 94.0%, 92.0%, and 90.9% patients who underwent surgery in an epidemic area were admitted to the intensive care unit in 2018, 2019, 2020, and 2021, respectively. However, the morbidity and mortality rates during the pandemic did not worsen according to the SMR values. CONCLUSIONS: Esophagectomy was performed during the pandemic despite limited medical resources by a systematic endeavor of the entire surgical department in Japan, without increasing the incidence rate of worse outcome.Jun. 2023, Esophagus : official journal of the Japan Esophageal Society, English, Domestic magazineScientific journal
- Jun. 2023, Annals of surgical oncology, English, International magazineScientific journal
- INTRODUCTION: We previously developed risk models for mortality and morbidity after low anterior resection using a nationwide Japanese database. However, the milieu of low anterior resection in Japan has undergone drastic changes since then. This study aimed to construct risk models for 6 short-term postoperative outcomes after low anterior resection, i.e., in-hospital mortality, 30-day mortality, anastomotic leakage, surgical site infection except for anastomotic leakage, overall postoperative complication rate, and 30-day reoperation rate. METHODS: This study enrolled 120,912 patients registered with the National Clinical Database, who underwent low anterior resection between 2014 and 2019. Multiple logistic regression analyses were performed to generate predictive models of mortality and morbidity using preoperative information, including the TNM stage. RESULTS: We developed new risk prediction models for the overall postoperative complication and 30-day reoperation rates for low anterior resection, which were absent from the previous version. The concordance indices for each endpoint were: 0.82 for in-hospital mortality, 0.79 for 30-day mortality, 0.64 for anastomotic leakage, 0.62 for surgical site infection besides anastomotic leakage, 0.63 for complications, and 0.62 for reoperation. The concordance indices of all four models included in the previous version showed improvement. CONCLUSION: This study successfully updated the risk calculators for predicting mortality and morbidity after low anterior resection using a model based on vast nationwide Japanese data.Jun. 2023, Digestive surgery, English, International magazineScientific journal
- Jun. 2023, Annals of surgical oncology, English, International magazineScientific journal
- (株)医学書院, Jun. 2023, 臨床外科, 78(6) (6), 696 - 702, Japanese
- 大道学館出版部, Jun. 2023, 臨牀と研究, 100(6) (6), 694 - 698, Japanese【食道・胃・大腸癌の最新情報】胃癌 胃がん内視鏡治療の進歩
- Jun. 2023, Annals of surgical oncology, 30(6) (6), 3803 - 3804, English, International magazineScientific journal
- BACKGROUND: Proficiency of the operating surgeon is one of the most critical factors potentially associated with reductions in complications and surgery-related mortality. With video-rating systems having shown potential for assessing laparoscopic surgeons' proficiency, the Endoscopic Surgical Skill Qualification System (ESSQS) was developed by the Japan Society for Endoscopic Surgery to subjectively assess the proficiency of laparoscopic surgeons by rating applicants' non-edited case videos. We conducted a study to evaluate how ESSQS skill-qualified (SQ) surgeon involvement influences short-term outcomes of laparoscopic gastrectomy performed for gastric cancer. METHODS: Data from the National Clinical Database regarding laparoscopic distal and total gastrectomy performed for gastric cancer between January 2016 and December 2018 were analyzed. Operative mortality, defined as 30-day mortality or 90-day in-hospital mortality, and anastomotic leakage rates were compared per involvement vs. non-involvement of an SQ surgeon. Outcomes were also compared per involvement of a gastrectomy-, colectomy-, or cholecystectomy-qualified surgeon. The association between the area of qualification and operative mortality/anastomotic leakage was also analyzed with a generalized estimating equation logistic regression model used to account for patient-level risk factors and institutional differences. RESULTS: Of 104,093 laparoscopic distal gastrectomies, 52,143 were suitable for inclusion in the study; 30,366 (58.2%) were performed by an SQ surgeon. Of 43,978 laparoscopic total gastrectomies, 10,326 were suitable for inclusion; 6501 (63.0%) were performed by an SQ surgeon. Gastrectomy-qualified surgeons outperformed non-SQ surgeons in terms of both operative mortality and anastomotic leakage. They also outperformed cholecystectomy- and colectomy-qualified surgeons in terms of operative mortality or anastomotic leakage in distal and total gastrectomy, respectively. CONCLUSION: The ESSQS appears to discriminate laparoscopic surgeons who can be expected to achieve significantly improved gastrectomy outcomes.Jun. 2023, Surgical endoscopy, 37(6) (6), 4627 - 4640, English, International magazineScientific journal
- BACKGROUND: Although neoadjuvant treatment has become the standard of care for patients with locally advanced esophageal cancer, previous studies comparing neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) have demonstrated inconclusive results. METHODS: Our study cohort included 3978 patients from 85 institutions. Those who underwent NAC or NACRT followed by surgery for esophageal squamous cell carcinoma (ESCC) were eligible for inclusion. We used the inverse probability of treatment weighting (IPTW) method to compare the outcomes between NAC and NACRT. RESULTS: Among the 3978 patients, 3777 (94.9%) received NAC and 201 (5.1%) received NACRT. After IPTW adjustment, the NACRT group had more patients with pathologically downstaged diseases and significantly better pathological response compared with the NAC group (p < 0.001); however, 5-year overall survival (OS), recurrence-free survival (RFS), and regional recurrence-specific survival (RRSS) were comparable between the groups. Subgroup analysis stratifying patients according to cT category showed that among cT1-2 patients, those in the NACRT group had significantly longer 5-year OS, RFS, and RRSS than those in the NAC group (P = 0.024, < 0.001, and 0.020, respectively). In contrast, no significant differences were observed among cT3-4a patients. The competing risks regression model showed comparable subdistribution hazard ratios for 10-year cancerous and noncancerous deaths between the NAC and NACRT groups. CONCLUSIONS: Compared with NAC, NACRT for ESCC did not promote better survival despite better therapeutic effects and did not increase noncancerous deaths.Jun. 2023, Annals of surgical oncology, English, International magazineScientific journal
- Abstract Background The coronavirus disease 2019 (COVID‐19) pandemic had resulted in either failure to provide required medical resources or delayed treatment for gastric cancer patients. This study aimed to investigate the impact of COVID‐19 on the incidence of postoperative complications using a nationwide Japanese database of patients undergoing distal gastrectomy for gastric cancer. Methods We collected the data of patients who underwent distal gastrectomy from January 2018 to December 2021 from the National Clinical Database (NCD), a web‐based surgical registration system in Japan. The number of surgical cases, the use of intensive care units, and the incidence of morbidity per month were analyzed. We also calculated the standardized mortality ratio (SMR), defined as the ratio of the number of observed patients to the expected number of patients calculated using the risk calculator established in the NCD, for several morbidities, including pneumonia, sepsis, 30‐day mortality, and surgical mortality. Results A decrease of 568 gastrectomies was observed from April 2020 to May 2020. Although the absolute number of patients admitted to intensive care units had declined since 2020, the proportion of patients admitted to the ICU did not change before and after the pandemic. Mortality and critical morbidity (such as pneumonia and sepsis) rates were not worse during the pandemic compared to pre‐pandemic periods per the SMR. Conclusions Surgical management was conducted adequately through the organized efforts of the entire surgery department in our country even in a pandemic during which medical resources and staff may have been limited.Wiley, May 2023, Annals of Gastroenterological Surgery, 7(6) (6), 887 - 895Scientific journal
- (一社)日本外科学会, May 2023, 日本外科学会雑誌, 124(3) (3), 253 - 260, Japanese【がん診療における層別化医療の現状と今後の展望】胃がんにおける層別化医療の現状と今後の展望
- BACKGROUND: The thoracic duct (TD) plays an important role in nutrition and immunity but is often resected with the esophagus when dissecting surrounding lymph nodes in patients with esophageal squamous cell carcinoma (ESCC). We examined whether indiscriminate TD resection improved the prognosis of patients with ESCC treated with neoadjuvant chemoradiotherapy (NACRT) followed by esophagectomy. METHODS: A total of 440 patients treated with NACRT followed by esophagectomy between 2007 and 2012 were analyzed using data from the Comprehensive Registry of Esophageal Cancer in Japan. The propensity score-matched TD resection and TD preservation groups were compared in terms of short- and long-term outcomes. RESULTS: After matching, there were 85 patients in both groups. No significant differences were found between groups in either overall survival or cause-specific survival rates at 5 years: 44.2% and 49.0% in the TD resection group, and 39.8% and 47.2% in the TD preservation group, respectively. Furthermore, the number of retrieved mediastinal lymph nodes was significantly greater in the TD resection group than in the TD preservation group (26 vs. 15, p < 0.0001). In contrast, TD resection was associated with metastasis to a significantly greater number of distant organs than TD preservation (49 vs. 32, p = 0.049). CONCLUSIONS: TD resection did not contribute to improved survival in patients with ESCC but did lead to metastases in more organs than TD preservation. Consequently, indiscriminate TD resection might be avoided in patients with ESCC treated with NACRT followed by esophagectomy.May 2023, Annals of surgical oncology, 30(5) (5), 2691 - 2698, English, International magazineScientific journal
- May 2023, Annals of surgical oncology, 30(5) (5), 2699 - 2700, English, International magazineScientific journal
- May 2023, Annals of surgical oncology, 30(5) (5), 2701 - 2702, English, International magazineScientific journal
- BACKGROUND: Although transanal total mesorectal excision (TaTME) is a promising treatment for low rectal cancer, it is considered technically demanding, and the number of cases required to become proficient in TaTME remains unknown. The purpose of this study was to assess the TaTME learning curve based on the total mesorectal excision completion time. STUDY DESIGN: This retrospective analysis comprised 128 individuals who received TaTME between September 2016 and December 2021. The cumulative sum method was used to generate the learning curve. The duration of the procedure from the beginning to the end of the circumferential rendezvous was used to define the total mesorectal excision completion time. RESULTS: The learning curve consists of 3 phases: phase I (learning phase: cases 1 to 38), phase II (consolidation phase: cases 39 to 70), and phase III (maturing phase: cases 71 to 128). As the phases varied, both the overall operative time and total mesorectal excision completion time decreased considerably. Through the 3 phases of TaTME, intraoperative adverse events decreased, and in phase III, none occurred. Only 1 instance of local recurrence occurred during phase III, and none occurred during phase I or II. CONCLUSIONS: After 70 operations, the surgeon could join the mastery phase of TaTME based on the total mesorectal excision completion time. After the mastering phase began, there were no intraoperative negative occurrences. From the beginning, the oncological safety could be guaranteed.May 2023, Journal of the American College of Surgeons, 236(5) (5), 1054 - 1063, English, International magazineScientific journal
- Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are therapeutic drugs for various other diseases. He delivered hope to patients with various diseases across the world to improve their condition. Even now, drug discovery research based on Dr. Fujii's ideas is continuing.May 2023, International journal of clinical oncology, 28(5) (5), 613 - 624, English, Domestic magazineScientific journal
- AIM: The National Clinical Database (NCD) of Japan is a nationwide data entry system for surgery, and it marked its 10th anniversary in 2020. The aim was to present the 2020 annual report of gastroenterological surgery of the NCD. METHODS: The data of the surgical procedures stipulated by the training curriculum for board-certified surgeons of the Japanese Society of Gastroenterological Surgery in the NCD from 2011 to 2020 were summarized. RESULTS: In total, 5 622 845 cases, including 593 088 cases in 2020, were extracted from the NCD. The total number of gastroenterological surgeries increased gradually in these 10 years, except for the year 2020 due to the COVID-19 pandemic. The annual number of surgeries of each organ, except the pancreas and liver, decreased by 0.4%-13.1% in 2020 compared to 2019. The surgical patients were consistently aging, with more than 20% of all gastroenterological surgeries in 2020 involving patients aged 80 years or older. The participation of board-certified surgeons increased for each organ (75.9%-95.7% in 2020). The rates of endoscopic surgery also increased constantly. Although the incidences of postoperative complications of each organ increased by 0.7%-7.9% in these 10 years, postoperative mortality rates decreased by 0.2%-1.5%. CONCLUSIONS: We present here the short-term outcomes of each gastroenterological operative procedure in 2020. This review of the 10-years of NCD data of gastroenterological surgery revealed a consistent increase of the number of surgeries (except for in 2020), especially endoscopic procedures, and aging of the Japanese population. The good safety of Japanese gastroenterological surgeries was also indicated.May 2023, Annals of gastroenterological surgery, 7(3) (3), 367 - 406, English, Domestic magazineScientific journal
- AIM: This study aimed to investigate the effect of the coronavirus disease pandemic on the number of surgeries for gastroenterological cancer cases in Japan. METHODS: The data recorded in the National Clinical Database of Japan between 2018 and 2020 were utilized for this study. Five specific surgeries for primary cancers and surgery for acute diffuse peritonitis were considered the primary endpoints. We divided the study period into the prepandemic and postpandemic (after April 2020) periods and examined the number of surgeries in relation to clinical factors. RESULTS: Overall, 228 860 surgeries were analyzed. Among the five primary cancer surgeries, the number of distal gastrectomies for gastric cancer decreased the most (to 81.0% of the monthly number in the prepandemic period), followed by that of low anterior resections for rectal cancer (91.4%). In contrast, the number of pancreaticoduodenectomies for pancreatic cancer increased by 7.1%, while that of surgeries for peritonitis remained stable. This trend was observed nationwide. We also noted a marked reduction in the number of distal gastrectomy (to 72.5%), low anterior resection (84.0%), and esophagectomy (88.8%) procedures for T1 tumors. The noncurative resection rate and mortalities were low despite the increased proportion of T4 tumors and older patients. CONCLUSION: A marked reduction in surgeries for gastric and rectal cancers with early T factors may reflect prioritization of surgeries and reduction in cancer screenings. Although the quality of the surgery was maintained in terms of reduced mortalities and morbidities, the long-term effects of this pandemic should be monitored.May 2023, Annals of gastroenterological surgery, 7(3) (3), 407 - 418, English, Domestic magazineScientific journal
- PURPOSE: Narrow pelvis, tumor diameter, and obesity have been reported as clinical variables correlated with the difficulty of conventional laparoscopic low anterior resection (Lap-LAR). A two-team transanal total mesorectal excision (TaTME) approach where the transabdominal and TaTME are performed simultaneously might reduce the difficulty associated with these factors. This study aimed to clarify the factors associated with the longer time required for TME (TME time) in conventional Lap-LAR and a two-team approach for TaTME. METHODS: We analyzed 52 patients with rectal carcinoma treated with Lap-LAR and 35 patients treated with TaTME. We performed simple linear regression analysis to assess the association between TME time and bony pelvic size using 3D pelvimetry, longest tumor diameter, and body mass index (BMI). RESULTS: Linear regression analysis demonstrated a highly significant association between TME time and obstetric conjugate (R2 = 0.098, P = .024) and BMI (R2 = 0.307, P < .001) in the Lap-LAR group, while no significant association was observed in the TaTME group. Male patients, who had a narrower bony pelvis and higher BMI than female patients, had longer TME time than female patients in the Lap-LAR group (213 minutes vs 172 minutes, P = .021), while the TME time of male and female patients did not differ in the TaTME group (122 minutes vs 108 minutes, P = .451). The TME time in the TaTME group was significantly shorter than that in the Lap-LAR group (121 minutes vs 197 minutes, P < .001). CONCLUSION: A two-team TaTME approach provided a shorter TME time compared to conventional Lap-LAR, regardless of pelvic size and BMI.Apr. 2023, Asian journal of endoscopic surgery, 16(2) (2), 189 - 196, English, Domestic magazineScientific journal
- BACKGROUND: We previously reported that postoperative recurrence in responders occurred in the regional field mostly as a solitary lesion without distant failure. However, further validation is necessary due to the low percentage of pathological responders, especially those with pCR. This study aimed to validate the prognostic impact of pathological response and the distribution of residual tumors in pathological responders using a nationwide database from 85 Japanese esophageal centers. METHODS: We retrospectively reviewed patients with esophageal squamous cell carcinoma (ESCC) who underwent subtotal esophagectomy at 85 authorized institutes for esophageal cancer between 2010 and 2015. The recurrence free survival (RFS), overall survival (OS), and recurrent tumor patterns were compared among the pathological responses. RESULTS: Of 4781 patients initially enrolled, 3840 were selected for subsequent analysis, including 237 patients with pathological complete response (pCR, 6%). The RFS and OS were significantly correlated with pathological response. When the recurrence pattern was classified into regional or distant recurrence, the incidence of distant failure was significantly lower in patients with pCR in cT1/2. Three percent of all patients with pCR in cT1/2 encountered postoperative recurrence in distant organs. CONCLUSION: The prognostic impact of pathological response was reproduced in the nationwide data. pCR in ESCC patients with cT1/2 provides a favorable prognosis with less incidence of distant failure. This finding may contribute to selecting appropriate candidates for an organ preservation approach based on the response to induction therapy.Apr. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(2) (2), 205 - 214, English, Domestic magazineScientific journal
- BACKGROUND: Neoadjuvant treatment has become the standard of care for patients with advanced esophageal cancer. However, few studies have elucidated the clinical factors that predict response to neoadjuvant therapy in a large multicenter cohort. We aimed to develop a predictive model of therapeutic effect in patients with esophageal squamous cell carcinoma (SCC) who received neoadjuvant treatment. METHODS: This nationwide study included 4078 patients from 85 institutions. Patients who received neoadjuvant treatment followed by surgery for esophageal SCC were eligible. We developed a logistic regression model to predict good pathological therapeutic effects, and a predictive nomogram was generated by applying the logistic regression formula. RESULTS: Among neoadjuvant regimens, cisplatin plus 5-fluorouracil (CF) was the most frequently used (60.2%), followed by docetaxel plus CF (DCF, 27.4%), CF with radiotherapy (CF-RT, 4.5%), adriamycin plus CF (3.6%), nedaplatin plus 5-fluorouracil (0.9%), and DCF-RT (0.5%). Multivariable analysis revealed that male sex, advanced cT category, and increased pretherapeutic SCC antigen level were independently associated with not achieving a good therapeutic effect. Moreover, intensified neoadjuvant regimens were independently associated with favorable therapeutic effects; DCF-RT elicited the best therapeutic effect, followed by CF-RT and DCF. A predictive model including nine commonly measured preoperative variables was generated, and the area under the curve was 0.679 (95% confidence interval: 0.658-0.700). This nomogram was also adequately validated internally. CONCLUSIONS: The model developed in this study was validated and predicts the therapeutic effect in patients with esophageal SCC who received neoadjuvant treatment. This model might contribute to individualized treatment strategies.Apr. 2023, Annals of surgical oncology, 30(4) (4), 2176 - 2185, English, International magazineScientific journal
- Apr. 2023, Annals of surgical oncology, 30(4) (4), 2186 - 2187, English, International magazineScientific journal
- BACKGROUND: Esophagectomy for esophageal carcinoma is associated with higher morbidity and mortality rates than other gastrointestinal surgeries. Smoking is an established risk factor for postoperative complications after esophagectomy. This study aimed retrospectively to investigate the impact of smoking status on short- and long-term outcomes for patients undergoing thoracoscopic esophagectomy in the prone position (TEP) for esophageal carcinoma. METHODS: In this study, 234 patients with esophageal carcinoma who underwent TEP between 2012 and 2020 were divided into two groups based on smoking status (current or non-current smokers and the Brinkman index) by patients' declarations. Postoperative complications (Clavien-Dindo classification grade ≥2), overall survival (OS), and disease-free survival (DFS) were compared between smoking statuses. RESULTS: The rates of postoperative complications did not differ significantly between the two groups (current smoker vs non-current smoker; Brinkman index ≥800 vs <800). The rate of postoperative pneumonia was higher in the combination group of current and higher Brinkman index (≥800) smokers than in the other group (25.0 % vs 11.8 %; P = 0.036). Multivariate analysis showed that smoking status was an independent risk factor for postoperative pneumonia (hazard ratio, 0.41; 95 % confidence interval, 0.18-0.93; P = 0.037). According to the long-term outcomes, no significant differences in OS and DFS were observed between the smoking statuses. CONCLUSIONS: The combination of current smoking and heavy smoking history is a risk factor for postoperative pneumonia in patients who have esophageal carcinoma treated with TEP, although no correlation was observed between the long-term outcomes and smoking status.Apr. 2023, Annals of surgical oncology, 30(4) (4), 2202 - 2211, English, International magazineScientific journal
- Apr. 2023, Annals of surgical oncology, 30(4) (4), 2188 - 2189, English, International magazineScientific journal
- PURPOSE: Laparoscopic surgery for low rectal cancer is often challenging. Transanal total mesorectal excision (TaTME) and robotic surgery have been introduced to overcome the technical difficulties in laparoscopic surgery and achieve more favorable outcomes. Hybrid robotic surgery, which combines TaTME with the abdominal robotic approach, incorporates the advantages of each of these surgical techniques and might achieve less invasive and safer surgery. This study evaluated the safety and feasibility of hybrid robotic surgery with TaTME (hybrid TaTME). METHODS: We retrospectively reviewed 162 TaTME cases performed at our department from September 2016 to May 2022. Among them, 92 cases of conventional TaTME and 30 of hybrid TaTME were eligible. We used propensity score matching analysis (PSM) to adjust for patients' characteristics and compared the short-term outcomes of the two treatment groups. RESULTS: Twenty-seven cases in each group were extracted using PSM. The operation time in hybrid TaTME was comparable to that in conventional TaTME. There was no significant difference in the postoperative hospital stay between the two groups. Other intra- and post-operative outcomes were also comparable between the two groups. Furthermore, no significant differences were observed between the two groups in the curative resection and recurrence rates. CONCLUSION: Hybrid TaTME for low rectal cancer was as favorable as conventional TaTME in producing satisfactory short-term outcomes. However, furthermore, larger-scale studies conducted over longer study periods are needed to evaluate the validity of the findings.Mar. 2023, Langenbeck's archives of surgery, 408(1) (1), 129 - 129, English, International magazineScientific journal
- 兵庫県外科医会, Mar. 2023, 兵庫県外科医会会誌, 57, 42 - 45, Japanese
- AIM: There have been no reports of searching for metastases to lymph nodes along the accessory middle colic artery (aMCA). The aim of this study was to investigate the metastasis rate of the aMCA for splenic flexural colon cancer. METHODS: Patients with histologically proven colon carcinoma located in the splenic flexure, clinically diagnosed as stage I-III were eligible for this study. Patients were retrospectively and prospectively enrolled. The primary endpoint was frequency of lymph node metastasis to the aMCA (station 222-acc and 223-acc). The secondary endpoint was the frequency of lymph node metastasis to the middle colic artery (MCA) (station 222-lt and 223) and left colic artery (LCA) (station 232 and 253). RESULTS: Between January 2013 and February 2021, a total of 153 consecutive patients were enrolled. The location of the tumor was 58% in the transverse colon and 42% in the descending colon. Lymph node metastases were observed in 49 cases (32%). The presence of aMCA rate was 41.8% (64 cases). The metastasis rates of stations 221, 222-lt, and 223 were 20.0%, 1.6%, and 0%, and stations 231, 232, and 253 were 21.4%, 1.0%, and 0%, respectively. The metastasis rates of stations 222-acc and 223-acc were 6.3% (95% confidence interval: 1.7%-15.2%) and 3.7% (95% confidence interval: 0.1%-19%), respectively. CONCLUSIONS: This study identified the distribution of lymph node metastases from splenic flexural colon cancer. If the aMCA is present, this vessel should be targeted for dissection, taking into account the frequency of lymph node metastasis.Mar. 2023, Annals of gastroenterological surgery, 7(2) (2), 265 - 271, English, Domestic magazineScientific journal
- PURPOSE: This study aimed to compare motions of the laparoscope tip during a laparoscopic task in a training box using a recent joystick-guided robotic scope holder to those manipulated by human scopists. We hypothesized that laparoscopic manipulation could be positively affected by robotic scope holders due to the elimination of unintentional movement. METHODS: Twelve surgeons participated as operators, and eight medical doctors participated in this study. Among the human scopists, five were trained surgeons and three were novices who had no experience with laparoscopic surgery. A validated laparoscopic task was used to evaluate the path length of the laparoscope tip using an optical position tracker and operative time. The operators performed the designated camera task under three different laparoscopic manipulations: using a joystick-guided robotic scope holder, expert human scopists, and novice scopists. RESULTS: The median path lengths (cm) of the laparoscopic tip were 94.0, 110.0, and 122.2 in the robotic scope holder, expert, and novice groups, respectively. The path lengths in the robotic scope holder group were significantly shorter than those in the other groups (P < .01). The median operative times (seconds) were 136.6, 66.4, and 62.3 in the robotic scope holder, expert, and novice groups, respectively. The operative time of the robotic scope holder group was significantly longer than that of the other groups (P < .001). CONCLUSION: A robotic scope holder can provide shorter camera movement owing to the stable holding and intentional scope manipulation by the operator, although it requires a longer operative time than a human assistant.Feb. 2023, Surgical innovation, 15533506231157039 - 15533506231157039, English, International magazineScientific journal
- (一社)日本外科感染症学会, Feb. 2023, 日本外科感染症学会雑誌, 19(4-5) (4-5), 374 - 379, Japanese
- PURPOSE: A research subgroup was established by the Japanese Society of Gastroenterological Surgery to improve the health care quality in the Chushikoku area of Western Japan. METHODS: The records of four surgical procedures were extracted from the Japanese National Clinical Database and analyzed retrospectively to establish the association between hospital characteristics, defined using a combination of hospital case-volume and patients' hospital travel distance, and the incidences of perioperative complications of ≥ Grade 3 of the Clavien-Dindo classification after gastroenterological surgery. RESULTS: This study analyzed 11,515 cases of distal gastrectomy for gastric cancer, 4,705 cases of total gastrectomy for gastric cancer, 4,996 cases of right hemicolectomy for colon cancer, and 5,243 cases of lower anterior resection for rectal cancer, with composite outcome incidences of 5.6%, 10.2%, 5.5%, and 10.7%, respectively. After adjusting for patient characteristics and surgical procedures, no association was identified between the hospital category and surgical outcomes. CONCLUSION: The findings of our study of the Chushikoku region did not provide positive support for the consolidation and centralization of hospitals, based solely on hospital case volume. Our grouping was unique in that we included patient travel distance in the analysis, but further investigations from other perspectives are needed.Feb. 2023, Surgery today, 53(2) (2), 214 - 222, English, Domestic magazineScientific journal
- BACKGROUND: Although lateral pelvic lymph node dissection (LLND) might be an effective approach for patients with rectal cancer with lateral lymph node metastasis, it is technically challenging because of the anatomical complexity and location of the deep pelvis. An assistance by transanal approach might be useful for a successful LLND. METHODS: From September 2016 to May 2021, 39 patients with low rectal cancer underwent transanal total mesorectal excision with LLND. Among them, 18 patients underwent LLND using a conventional laparoscopic approach alone, while the remaining 21 underwent LLND using both conventional and transanal approaches. Their clinical outcomes were retrospectively compared. RESULTS: The operation time for LLND on each side was significantly shorter in the transanal group (105 min vs. 54 min, P < 0.001). The intraoperative blood loss was also significantly less in the transanal group (40 g vs. 0 g, P = 0.031). The rate of overall postoperative complications ≥ grade II according to the Clavien-Dindo classification was significantly less in the transanal group (66.7% vs. 28.6%, odds ratio: 5.000, 95% confidence intervals: 1.313-19.047, P = 0.040). The number of harvested lateral lymph nodes in both groups was similar (8.5 vs. 8, P = 0.544). CONCLUSION: The transanal approach for LLND reduced operative time, blood loss, and morbidity compared with the conventional approach alone in a cohort of patients with rectal cancer.Feb. 2023, Surgical endoscopy, 37(2) (2), 1562 - 1568, English, International magazineScientific journal
- Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal cancer. This study aimed to investigate the association of Wnt/β-catenin signal activation with a pathological response to NACRT. The immunohistochemical expression of nuclear and membranous β-catenin was analyzed in biopsy samples obtained from 60 patients with locally advanced rectal cancer who received curative surgery following NACRT. The association of Wnt/β-catenin signal activation with their clinical outcomes was investigated. Notably, the body mass index of these patients was significantly higher in the low nuclear β-catenin expression group. Moreover, patients in the high nuclear β-catenin expression group tended to have more advanced disease and a higher rate of positive vascular invasion than those in the low expression group. Furthermore, the rate of good histological responses was significantly higher in the low nuclear β-catenin expression group (72% vs. 37.1%, p < 0.01). Overall, relapse-free survival tended to be better in patients with low nuclear/high membranous β-catenin expression (n = 9) than in other individuals (n = 51) (p = 0.093 and p = 0.214, respectively). Activation of the Wnt/β-catenin signal pathway represented by nuclear β-catenin accumulation was significantly associated with a poor response to NACRT in patients with rectal cancer. Analysis of nuclear β-catenin accumulation before starting treatment might help predict the therapeutic response to NACRT.Jan. 2023, Biomedicines, 11(1) (1), English, International magazineScientific journal
- High infiltration of tumor-associated macrophages (TAMs), which contribute to the progression of several cancer types, is correlated with poor prognosis of esophageal squamous cell carcinoma (ESCC). In addition to the previously reported increase in migration and invasion, ESCC cells co-cultured directly with macrophages exhibited enhanced survival and growth. Furthermore, interleukin-related molecules are associated with ESCC; however, the precise mechanism underlying this association is unclear. Therefore, we explored the role of interleukin-related molecules in ESCC progression. A cDNA microarray analysis of monocultured and co-cultured ESCC cells revealed that the interleukin 7 receptor (IL-7R) was upregulated in ESCC cells co-cultured with macrophages. Overexpression of IL-7R promoted the survival and growth of ESCC cells by activating the Akt and Erk1/2 signaling pathways. The IL-7/IL-7R axis also contributed to the promotion of ESCC cell migration via the Akt and Erk1/2 signaling pathways. Furthermore, immunohistochemistry showed that ESCC patients with high IL-7R expression in cancer nests exhibited a trend toward poor prognosis in terms of disease-free survival, and showed significant correlation with increased numbers of infiltrating macrophages and cancer-associated fibroblasts. Therefore, IL-7R, which is upregulated when directly co-cultured with macrophages, may contribute to ESCC progression by promoting the development of various malignant phenotypes in cancer cells.Jan. 2023, Cancers, 15(2) (2), English, International magazineScientific journal
- PURPOSE: Postoperative complications after esophagectomy can be severe or fatal and impact the patient's postoperative quality of life and long-term outcomes. The aim of the present study was to develop the best possible model for predicting mortality and complications based on the Japanese Nationwide Clinical Database (NCD). METHODS: Data registered in the NCD, on 32,779 patients who underwent esophagectomy via a thoracic approach for malignant esophageal tumor between January, 2012 and December, 2017, were used to create a risk model. RESULTS: The 30-day mortality rate after esophagectomy was 1.0%, and the operative mortality rate was 2.3%. Postoperative complications included pneumonia (13.8%), anastomotic leakage (13.2%), recurrent laryngeal nerve palsy (11.1%), atelectasis (4.9%), and chylothorax (2.5%). Postoperative artificial respiration for over 48 h was required by 7.8% of the patients. Unplanned intubation within 30 postoperative days was performed in 6.2% of the patients. C-indices evaluated using the test data were 0.694 for 30-day mortality and 0.712 for operative mortality. CONCLUSIONS: We developed a good risk model for predicting 30-day mortality and operative mortality after esophagectomy based on the NCD. This risk model will be useful for the preoperative prediction of 30-day mortality and operative mortality, obtaining informed consent, and deciding on the optimal surgical procedure for patients with preoperative risks for mortality.Jan. 2023, Surgery today, 53(1) (1), 73 - 81, English, Domestic magazineScientific journal
- BACKGROUND: With the aging of society and increasingly longer of life expectancy, elderly patients with esophageal cancer are more commonly encountered. This study aimed to identify the risk factors for operative mortality after esophagectomy in elderly patients. METHODS: We used data from the National Clinical Database of Japan. After cleaning the data, 10,633 records obtained from 861 hospitals were analyzed. A risk model for operative mortality was developed using risk factors from the entire study population. Then, odds ratios (OR) were compared between age categories using this risk model. RESULTS: In this study, 1959 (18.4%) patients were ≥ 75 years (defined as "elderly" in this study). Eighteen variables, including T4b, N2-N3, and M1 in the TNM classification, were included in the risk model for operative mortality. The ORs increased in age categories < 65, 65-74, and ≥ 75 years for N2-N3 (1.172, 1.200, and 1.588, respectively), and M1 (2.189, 3.164, and 4.430, respectively). Based on these results, we also focused on residual tumors, which are caused by extensive tumor development. The operative mortality in the elderly group with residual tumors increased to more than twice than that in the non-elderly groups (15.9 vs. 5.5 or 6.5%) and was much higher than that in elderly patients without residual tumors (15.9 vs. 4.6%). CONCLUSION: We should carefully select the treatment for elderly patients with highly advanced tumors, which result in N2-N3 and M1, to avoid unfavorable short-term outcomes. In addition, R0 resection is important in preventing operative mortality among elderly patients.Jan. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(1) (1), 39 - 47, English, Domestic magazineScientific journal
- BACKGROUND: Two prominent patient positions during thoracoscopic esophagectomy are the left lateral decubitus position (LP) and the prone position (PP). However, whether the patient position during thoracoscopic esophagectomy influences short-term outcomes, especially postoperative pneumonia, remains unclear. We aimed to elucidate the impact of patient position on the occurrence of postoperative pneumonia. METHODS: We analyzed 9850 patients who underwent oncologic thoracoscopic esophagectomies between 2016 and 2019 from the National Clinical Database. We compared the short-term outcomes between the LP and PP groups, and the primary outcome measure was the incidence of postoperative pneumonia. RESULTS: This study included 2637 (26.8%) and 7213 (73.2%) patients in the LP and the PP groups, respectively. The baseline characteristics of the two groups were well-balanced. Compared with the LP group, the PP group had a longer operative time and less blood loss. There were no significant differences in the incidences of postoperative pneumonia, recurrent laryngeal nerve palsy, anastomotic leakage, severe complications, and reoperation between the groups. Meanwhile, prolonged ventilation and surgery-related mortality occurred more frequently in the LP than in the PP group (P < 0.001 and 0.046, respectively). After multivariable adjustment, the patient position did not significantly influence the incidence of postoperative pneumonia (odds ratio 0.91, 95% confidence interval 0.80-1.04). CONCLUSIONS: Although prolonged ventilation and surgery-related mortality occurred more frequently in the LP group than in the PP group, the patient position did not significantly influence the occurrence of postoperative pneumonia.Jan. 2023, Esophagus : official journal of the Japan Esophageal Society, 20(1) (1), 48 - 54, English, Domestic magazineScientific journal
- BACKGROUND/AIM: Neoadjuvant chemotherapy (NAC) for advanced gastric cancer (GC) and esophagogastric junction cancer (EGC) is expected to effectively control the tumor; however, histological tumor response and immune function markers as prognostic factors for NAC remain unknown. This study assessed the prognostic significance of histological response and immune function markers in patients undergoing NAC for GC and EGC. PATIENTS AND METHODS: Forty-two patients who underwent NAC followed by surgical resection for operable advanced GC or EGC from January 2007 to December 2019 were divided into two groups based on histological response. Overall survival (OS), tumor response, and immune function markers, such as the neutrophil/lymphocyte ratio (NLR), were the outcomes analyzed. RESULTS: The 5-year OS for Grade 2b-3 (n=10, responder group) according to the Japanese Gastric Cancer Classification was 72.0% with a favorable prognosis, compared with 33.3% for Grade 0-1a (n=18), and 46.8% for Grade 1b-2a (n=14) in the non-responder group. There was no significant difference in the background between the two groups regarding clinical status or immune function markers. In a multivariate analysis of immune function markers, the NLR value before NAC was significantly associated with prognosis (p=0.048). Patients with an NLR value <3.4 had a favorable OS (p=0.03). CONCLUSION: Histological response scores for Grade 2b or higher may help predict a favorable prognosis for patients undergoing NAC for advanced GC and EGC. The outcomes may be further improved by considering NLR values.2023, In vivo (Athens, Greece), 37(1) (1), 378 - 384, English, International magazineScientific journal
- PURPOSE: Rectal or anal canal adenocarcinoma with inguinal lymph node metastasis (ILNM) is rare and is associated with poor prognostic outcomes. This study aimed to elucidate the clinical significance of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for rectal or anal canal adenocarcinoma with clinically suspected ILNM. METHODS: This study enrolled 15 consecutive patients who underwent neoadjuvant therapy and curative resection for rectal or anal canal adenocarcinoma with clinically suspected ILNM between 2005 and 2019 at a single institution. Inguinal lymph node dissection was selectively performed on the side of suspected metastasis before neoadjuvant therapy. Short- and long-term outcomes were retrospectively reviewed. RESULTS: Out of the15 patients, 11 were treated with neoadjuvant chemoradiation, three with chemotherapy, and one with chemoradiation followed by chemotherapy. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) scans were performed after neoadjuvant therapy in 14 patients. Five patients had negative FDG accumulation in inguinal lymph nodes on FDG-PET scan, and their inguinal lymph nodes were also pathologically negative for metastasis. Of the nine patients who had positive FDG accumulation, four had pathologically positive inguinal lymph nodes. Seven patients (46.7%) had inguinal seroma postoperatively. Five-year-overall survival was 77.5%, and 5-year-relapse-free survival was 64.2%. No patient had a recurrence in the inguinal region. CONCLUSION: In patients with rectal or anal canal adenocarcinoma associated with clinical ILNM, radical resection with neoadjuvant therapy provides a good long-term survival.Dec. 2022, Langenbeck's archives of surgery, 408(1) (1), 2 - 2, English, International magazineScientific journal
- Obesity, a known risk factor for various types of cancer, reduces the number and function of cytotoxic immune cells in the tumor immune microenvironment (TIME). However, the impact of obesity on CD4+ T cells remains unclear. Therefore, this study aimed to clarify the impact of obesity on CD4+ T cells in the TIME. A tumor-bearing obese mouse model was established by feeding with 45% high-fat diet (HFD), followed by inoculation with a colon cancer cell line MC38. Tumor growth was significantly accelerated compared to that in mice fed a control diet. Tumor CD4+ T cells showed a significant reduction in number and an increased expression of programmed death-1 (PD-1), and decreased CD107a expression and cytokine such as IFN-γ and TNF-α production, indicating dysfunction. We further established CD4+ T cell-depleted HFD-fed model mice, which showed reduced tumor infiltration, increased PD-1 expression in CD8+ T cells, and obesity-induced acceleration of tumor growth in a CD4+ T cell-dependent manner. These findings suggest that the reduced number and dysfunction of CD4+ T cells due to obesity led to a decreased anti-tumor response of both CD4+ and CD8+ T cells to ultimately accelerate the progression of colorectal cancer. Our findings may elucidate the pathogenesis for poor outcomes of colorectal cancer associated with obesity.Dec. 2022, Cells, 12(1) (1), English, International magazineScientific journal
- (株)癌と化学療法社, Dec. 2022, 癌と化学療法, 49(13) (13), 1711 - 1713, Japanese
- BACKGROUND: Many patients with esophageal squamous cell carcinoma (ESCC) have obstructive ventilatory disorder (OVD), which is considered a risk factor for postoperative pneumonia. It has been reported that thoracoscopic esophagectomy in the prone position (TEP) is less invasive and is associated with fewer postoperative respiratory complications compared with open esophagectomy. This matched-cohort study aimed to elucidate the safety and oncologic outcomes of ESCC patients with OVD who undergo TEP. METHODS: In this matched-cohort study, 237 patients with ESCC who underwent TEP between 2010 and 2018 were divided into two groups based on forced expiratory volume in 1 s/forced vital capacity. Postoperative complications (Clavien-Dindo classification grade II or higher), overall survival (OS), and disease-free survival (DFS) were compared between the two groups. RESULTS: Based on their propensity scores, 75 patients with normal respiratory function (NRF) and 75 with OVD were selected. The rates of postoperative pneumonia were not significantly different between the two groups (NRF group vs OVD group: 18.7% vs 18.7%; P = 1.000). The rates of recurrent laryngeal nerve palsy and anastomotic leakage were also not significantly different (NRF group vs OVD group: 12.0% vs 18.7%, P = 0.365; 18.7% vs 18.7%, P = 1.000). The 5-year OS and DFS rates in the NRF vs OVD groups were 66.2% vs 54.9% and 63.5% vs 52.9%, respectively, with no significant differences (P = 0.421, 0.197). CONCLUSIONS: TEP can be safely performed on ESCC patients with OVD and can result in an oncological efficiency equal to that of the NRF group.Dec. 2022, Surgical endoscopy, 36(12) (12), 8834 - 8842, English, International magazineScientific journal
- PURPOSE: To assess the increase in hospital costs associated with postoperative complications after lower anterior resection (LAR) for rectal cancer. METHODS: The subjects of this retrospective analysis were patients who underwent elective LAR surgery between April, 2015 and March, 2017, collected from a Japanese nationwide gastroenterological surgery registry linked to hospital-based claims data. We evaluated total and category-specific hospitalization costs based on the level of postoperative complications categorized using the Clavien-Dindo (CD) classification. We assessed the relative increase in hospital costs, adjusting for preoperative factors and hospital case volume. RESULTS: We identified 15,187 patients (mean age 66.8) treated at 884 hospitals. Overall, 71.8% had no recorded complications, whereas 7.6%, 10.8%, 9.0%, 0.6%, and 0.2% had postoperative complications of CD grades I-V, respectively. The median (25th-75th percentiles) hospital costs were $17.3 K (16.1-19.3) for the no-complications group, and $19.1 K (17.3-22.2), $21.0 K (18.5-25.0), $27.4 K (22.4-33.9), $41.8 K (291-618), and $22.7 K (183-421) for the CD grades I-V complication groups, respectively. The multivariable model identified that complications of CD grades I-V were associated with 11%, 21%, 61%, 142%, and 70% increases in in-hospital costs compared with no complications. CONCLUSIONS: Postoperative complications and their severity are strongly associated with increased hospital costs and health-care resource utilization. Implementing strategies to prevent postoperative complications will improve patients' clinical outcomes and reduce hospital care costs substantially.Dec. 2022, Surgery today, 52(12) (12), 1766 - 1774, English, Domestic magazineScientific journal
- [A Case of Pathological Complete Response after Conversion Surgery for HER2-Positive Advanced Gastric Cancer with Multiple Distant Metastases].The patient is a 70's man. Esophagogastroduodenoscopy and contrast-enhanced CT scan of the abdomen revealed gastric cancer, 2 liver metastases, and peritoneal dissemination. He was diagnosed with unresectable advanced gastric cancer and received 5 courses of chemotherapy(CapeOX plus T-mab). The primary tumor size had reduced, and liver metastases and peritoneal dissemination were not detectable, so laparoscopic distal gastrectomy and partial hepatectomy were performed. Histopathological findings revealed no viable cancer cells in either the primary tumor or the hepatic resection site, and the histological response was Grade 3. The patient has been recurrence-free for 6 months since the surgery. Even in Stage Ⅳ gastric cancer with multiple distant metastases, long-term survival may be expected by conversion surgery after response to chemotherapy.Dec. 2022, Gan to kagaku ryoho. Cancer & chemotherapy, 49(13) (13), 1711 - 1713, Japanese, Domestic magazineScientific journal
- (一社)日本外科学会, Nov. 2022, 日本外科学会雑誌, 123(6) (6), 589 - 591, JapaneseNCDデータから紡ぐ外科学の進歩 消化管領域におけるNCD研究の利活用
- (一社)日本外科学会, Nov. 2022, 日本外科学会雑誌, 123(6) (6), 592 - 595, JapaneseNCDデータから紡ぐ外科学の進歩 肝胆膵領域におけるNCDデータ解析研究とACS-NSQIPから学ぶ外科医療成績向上へのステップ
- BACKGROUND: The nationwide registry of the Japanese Gastric Cancer Association collected data of surgically resected cases of gastric cancer between 2001 and 2013. These retrospective analyses aimed to delineate tumor characteristics, surgical history, and survival distribution. METHODS: Data from 254,706 patients with primary gastric cancer were included. The 5-year survival rates were calculated for various subsets of prognostic factors. RESULTS: The number of patients over 70 years old increased from 2001 to 2013. The frequency with which laparoscopic gastrectomy was opted for increased dramatically (from 3.5 to 40.8%) in 13 years. We focused on the patients registered between 2010 and 2013, for whom data collection was based on the 3rd edition of the Japanese classification and guidelines. Five-year overall survival (OS) rate among 92,305 patients with resected tumors was 70.6%. The 5-year OS rates of patients with pathological stage IA, IB, IIA, IIB, IIIA, IIIB, IIIC, and IV disease were 89.6%, 83.2%, 77.6%, 68.1%, 59.3%, 45.6%, 29.9%, and 14.0%, respectively. CONCLUSION: Our detailed analysis highlights the historical changes in outcomes of surgically treated gastric malignancies in Japan, and provides robust dataset for future analysis.Nov. 2022, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 25(6) (6), 1082 - 1093, English, Domestic magazineScientific journal
- PURPOSE: No study has focused on the safety and feasibility of our previously developed open-window suturing technique to close mucosal defects on the pancreatic side after endoscopic submucosal dissection from the opened duodenal wall. This study aimed to evaluate the safety and usefulness of laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side of the duodenum. METHODS: This retrospective study included 61 consecutive patients who underwent surgery during August 2014-November 2021. After dissection when the tumor was on the pancreatic side, we sutured the mucosal defect from the opened duodenal wall. A preoperative endoscopic pancreatic stent was placed for tumors within 1 cm of the ampulla of Vater. The surgical outcomes were compared between tumors on the pancreatic and non-pancreatic sides. RESULTS: There were 27 and 34 patients with tumors on the pancreatic and non-pancreatic sides, respectively. The patient characteristics were similar. Preoperative pancreatic stents were placed in four patients in the pancreatic side group. The median operative time was significantly longer on the pancreatic side than in the non-pancreatic side group (241 vs. 209 min, P = 0.02). In one patient in the pancreatic side group, an intraoperative injury of the ampulla of Vater was successfully treated with intraoperative management. There were no significant differences in the incidence of postoperative grade II or higher complications between the groups. CONCLUSIONS: Laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side is safe and feasible.Nov. 2022, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2266 - 2273, English, International magazineScientific journal
- BACKGROUND/AIM: Although survival in cases with early recurrence after curative resection of colorectal cancer has been persistently poor, the risk factors for early recurrence remain unknown. PATIENTS AND METHODS: A total of 1,043 patients with stage I-III colorectal cancer underwent curative resection at Kobe University Hospital between April 2007 and September 2020. Of these, 122 patients developed recurrence: 57 had early recurrence (<1 year after surgery) and 65 patients had late recurrence (≥1 year after surgery). The clinicopathological features were compared between the groups and the risk factors for early recurrence were analyzed. RESULTS: Overall survival both from the date of recurrence and from the date of surgery were significantly worse in the early recurrence group. The proportion of the patients with ≥100 g of intraoperative blood loss, blood transfusion, and postoperative complications were significantly higher in the early recurrence group. R0 resection was achieved more frequently in the late recurrence group. Multivariate analysis revealed that no adjuvant chemotherapy, elevated preoperative CA19-9, blood transfusion, and the occurrence of the postoperative complication were independent risk factors for early recurrence. CONCLUSION: Early recurrence after curative resection of colorectal cancer was associated with worse overall survival. Adjuvant chemotherapy might be beneficial for patients with risk factors of early recurrence to improve prognosis.Nov. 2022, Anticancer research, 42(11) (11), 5553 - 5559, English, International magazineScientific journal
- AIM: The National Health Insurance system has reimbursed robotic gastrointestinal surgery since April 2018 in Japan. Additionally, strict facility and surgeon standards were established by the government and the academic society. This study aimed to evaluate the prevalence and safety of robotic surgery using a Japanese nationwide web-based database. METHODS: Patients who underwent the following robotic surgeries for malignant tumors in 2018 were included: esophagectomy (RE), total gastrectomy (RTG), distal gastrectomy (RDG), proximal gastrectomy (RPG), low anterior resection (RLAR), and rectal resections other than RLAR (RRR). The number of cases and surgical mortality rates each month were calculated to evaluate the prevalence and safety of robotic procedures. RESULTS: A total of 3281 patients underwent robotic gastrointestinal surgery. The monthly number of robotic surgeries nearly doubled in April 2018 when they were initially reimbursed by the National Health Insurance system. Operative mortality rates were 0.9%, 0.4%, 0.2%, and 2.8% for RE (n = 330), RTG (n = 239), RDG (n = 1167), and RPG (n = 109), respectively. No mortality was observed in RLAR (n = 1062) or RRR (n = 374). CONCLUSION: Robotic surgery for gastrointestinal malignant tumors was safely introduced into daily clinical practice along with rigorous surgeon and facility standards in Japan.Nov. 2022, Annals of gastroenterological surgery, 6(6) (6), 746 - 752, English, Domestic magazineScientific journal
- (株)医学書院, Oct. 2022, 臨床外科, 77(11) (11), 58 - 64, Japanese
- Oct. 2022, Annals of surgical oncology, 29(11) (11), 6867 - 6868, English, International magazineScientific journal
- BACKGROUND: Multidisciplinary treatment combining neoadjuvant treatment (NAT) and surgery has slightly improved the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Although various biomarkers targeting nutrition and inflammation are associated with cancer prognosis, most studies have focused on conditions prior to NAT. Developing real-time and sensitive biomarkers that monitor changes in systemic conditions during NAT is important. We established a novel nutritional and inflammatory index, represented as the albumin to derived neutrophil-to-lymphocyte ratio (Alb-dNLR), and calculated the change in Alb-dNLR (ΔAlb-dNLR) during neoadjuvant chemotherapy (nCT). In this study, we aimed to evaluate whether ΔAlb-dNLR is associated with prognosis in patients with ESCC. METHODS: We investigated 172 patients who underwent nCT before esophagectomy between April 2010 and March 2018. The dNLR was calculated as the ratio of neutrophil count to (white blood cell count - neutrophil count), Alb-dNLR was calculated by dividing the serum albumin level by the dNLR, and ΔAlb-dNLR was evaluated by dividing the post-Alb-dNLR by the pre-Alb-dNLR. Patients were divided into 'high' and 'low' groups according to the ΔAlb-dNLR. RESULTS: Thirty-nine patients (22.7%) had a low ΔAlb-dNLR (≤ 0.8), and the 5-year overall survival (OS) rates in patients with low and high ΔAlb-dNLR were 38.1% and 53.6%, respectively (p = 0.0072). Multivariate analyses demonstrated that estimated blood loss (p = 0.044), pathological T stage (p = 0.0005), pathological N stage (p = 0.017), and ΔAlb-dNLR (p = 0.005) were independent prognostic factors for OS. CONCLUSIONS: ΔAlb-dNLR is a useful prognostic factor for OS in patients with ESCC receiving nCT.Oct. 2022, Annals of surgical oncology, 29(11) (11), 6860 - 6866, English, International magazineScientific journal
- Oct. 2022, Annals of surgical oncology, 29(11) (11), 6869 - 6870, English, International magazineScientific journal
- BACKGROUND: One upside of cervical esophageal carcinoma is that radical surgery can be performed by laryngectomy, even for tumors with tracheal invasion. However, this approach drastically reduces the quality of life, such as by losing the vocal function. Cervical esophageal carcinoma is rare, and no comprehensive reports have described the current state of surgery. Using a Japanese nationwide web-based database, we analyzed the surgical outcomes of cervical esophageal carcinoma to evaluate the impact of larynx-preserving surgery. METHODS: Based on the Japan National Clinical Database, 215 surgically treated cases of cervical esophageal carcinoma between January 1, 2018, and December 31, 2019, were enrolled. Clinical outcomes were compared between the larynx-preserved group and the laryngectomy group. RESULTS: Ninety-four (43.7%) patients underwent larynx-preserving surgery. A total of 177 (82.3%) patients underwent free jejunum reconstruction. More T4b patients and more patients who underwent preoperative radiotherapy were in the laryngectomy group. There were no significant differences in the frequency and the severity of morbidities between the two groups. However, in the laryngectomy group, in-hospital death within 30 days after surgery was observed in 1 patient, and the postoperative hospital stay was significantly longer (P = 0.030). In the larynx-preserved group, recurrent nerve paralysis was observed in 24.5%. Re-operation (35.3%, P = 0.016), re-intubation (17.6%, P = 0.019) and tracheal necrosis (17.6%, P = 0.028) were significantly more frequent in patients who underwent pharyngolaryngectomy with total esophagectomy and gastric tube reconstruction than in others. CONCLUSION: Larynx-preserving surgery was therefore considered to be feasible because it was equivalent to laryngectomy regarding the short-term surgical outcomes.Oct. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(4) (4), 569 - 575, English, Domestic magazineScientific journal
- The risk factors for delayed gastric emptying (DGE) following gastrectomy are unclear. This study aimed to investigate the risk factors for DGE and the severity of DGE. We retrospectively evaluated 412 patients who underwent gastrectomy for gastric cancer between 2011 and 2019. The cases were classified into the DGE (n = 27) and non-DGE (n = 385) groups; the DGE group was further classified into two subgroups based on nasogastric tube insertion as an indicator of severity. For determining the relationship between resected stomach volume and DGE, we calculated the area of each surgical specimen using the ImageJ software. Female sex (odds ratio [OR] 2.55; 95% confidence interval [CI] 1.09-5.93; P = 0.03), diabetes (OR 2.38; 95% CI 1.02-5.57; P = 0.03), and distal gastric tumors (OR 2.61; 95% CI 1.10-6.19; P = 0.02) were identified as independent risk factors by multivariate analysis. The duration of hospital stay was longer in the DGE group than in the non-DGE group (29 vs. 15 days, P < 0.01). Overall, 24 cases of DGE (89%) were found in more than 1 week following surgery. No correlation was observed between clinical features and the severity of DGE. The resected area in the DGE group was significantly larger than that in the non-DGE group (198.0 vs. 173.9 cm2, P = 0.03). In conclusion, DGE was frequently observed in females and in patients with diabetes and distal gastric tumors. Most of the DGE cases occurred after 7-14 days of surgery, patients who are discharged early should be informed to seek hospitalization if they have symptoms caused by DGE.Sep. 2022, Scientific reports, 12(1) (1), 15903 - 15903, English, International magazineScientific journal
- Importance: Women are vastly underrepresented in surgical leadership and management in Japan. The lack of equal opportunities for surgical training is speculated to be the main reason for this disparity; however, this hypothesis has not been investigated thus far. Objective: To examine gender disparity in the number of surgical experiences among Japanese surgeons. Design, Setting, and Participants: This retrospective, multicenter cross-sectional study used data from the National Clinical Database, which contains more than 95% of all surgical procedures in Japan. Participants included male and female gastroenterological surgeons who performed appendectomy, cholecystectomy, right hemicolectomy, distal gastrectomy, low anterior resection, and pancreaticoduodenectomy between January 1, 2013, and December 31, 2017. Exposures: Differences in the number of surgical experiences between male and female surgeons. Main Outcomes and Measures: The primary outcomes were the total number of operations and number of operations per surgeon by gender and years of experience. Data were analyzed from March 18 to August 31, 2021. Results: Of 1 147 068 total operations, 83 354 (7.27%) were performed by female surgeons and 1 063 714 (92.73%) by male surgeons. Among the 6 operative procedures, the percentage of operations performed by female surgeons were the highest for appendectomy (n = 20 648 [9.83%]) and cholecystectomy (n = 41 271 [7.89%]) and lowest for low anterior resection (n = 4507 [4.57%]) and pancreaticoduodenectomy (n = 1329 [2.64%]). Regarding the number of operations per surgeon, female surgeons had fewer surgical experiences for all 6 types of operations in all years after registration, except for appendectomy and cholecystectomy in the first 2 years after medical registration. The largest gender disparity for each surgical procedure was 3.17 times more procedures for male vs female surgeons for appendectomy (at 15 years after medical registration), 4.93 times for cholecystectomy (at 30-39 years), 3.65 times for right hemicolectomy (at 30-39 years), 3.02 times for distal gastrectomy (at 27-29 years), 6.75 times for low anterior resection (at 27-29 years), and 22.2 times for pancreaticoduodenectomy (at 30-39 years). Conclusions and Relevance: This cross-sectional study found that female surgeons had less surgical experience than male surgeons in Japan, and this gap tended to widen with an increase in years of experience, especially for medium- and high-difficulty operations. Gender disparity in surgical experience needs to be eliminated, so that female surgeons can advance to leadership positions.Sep. 2022, JAMA surgery, 157(9) (9), e222938, English, International magazineScientific journal
- (株)へるす出版, Aug. 2022, 消化器外科, 45(8) (8), 851 - 857, Japanese【これ一冊ですべて網羅!消化器の吻合方法】総論 吻合法の基礎 器械吻合
- 金原出版(株), Aug. 2022, 手術, 76(9) (9), 1475 - 1488, Japanese
- BACKGROUND: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor node metastasis (AJCC-TNM 8th) system adopted the newly separate post-neoadjuvant pathologic stage group (ypTNM). However, it is not compatible with the Japanese pathologic classification after neoadjuvant chemotherapy (JPN-CT-pTNM). The aim of this study is to clarify the subjects of the AJCC-ypTNM 8th and propose a unification of the AJCC and Japanese systems to create novel AJCC-CT-pTNM 8th. METHODS: Participants were 304 esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemotherapy followed by 3 stage esophagectomy between 2010 and 2019. Predictive probabilities of pN, pM in AJCC-ypTNM 8th and JPN-CT-pTNM 11th systems were evaluated to propose novel system. RESULTS: In training data from 234 patients, the overall survival rate was statistically better for ypStage IIIA than ypStage II (P = 0.040) resulting in staging inversion in AJCC-ypTNM 8th. Predictive probability of pathological N status in AJCC-ypTNM 8th (Akaike Information Criterion: AIC = 979.53) was superior to that in JPN-CT-pTNM 11th (AIC = 999.07). In AJCC-ypTNM 8th, 71% (15/21) of ypM1 diseases were supraclavicular lymph nodes (No. 104 L/N as regional in JPN-CT-pTNM 11th) metastases with considerably good prognosis. The predictive probability of the novel AJCC-CT-pTNM 8th [unification of ypStage II and IIIA, conversion of supraclavicular L/Ns metastases from ypM to ypN] (AIC = 1054.24) was superior to that of the existing AJCC-ypTNM 8th (AIC = 1070.74). The feasibility of novel system was validated using test data from 70 patients. CONCLUSIONS: Unification of the AJCC and Japanese systems yields a simpler and more precise predictive system after neoadjuvant chemotherapy.Aug. 2022, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(8) (8), 1760 - 1767, English, International magazineScientific journal
- OBJECTIVE: The Endoscopic Surgical Skill Qualification System (ESSQS) was developed by the Japan Society for Endoscopic Surgery as a means of subjectively assessing the proficiency of laparoscopic surgeons. We conducted a study to evaluate how involvement of an ESSQS skill-qualified (SQ) surgeon influences short-term outcomes of laparoscopic cholecystectomy performed for acute cholecystitis. Previous reports suggest that assessment of the video-rating system is a potential tool to discriminate laparoscopic surgeons' proficiency and top-rated surgeons face less surgical mortality and morbidity in bariatric surgery. METHODS: Data from the National Clinical Database regarding laparoscopic cholecystectomy performed for acute cholecystitis between January 2016 and December 2018 were analyzed. Outcomes were compared between patients grouped according to involvement vs. non-involvement of an SQ surgeon. Outcomes were also compared between patients grouped according to whether their operation was performed by biliary tract-, stomach-, or colon-qualified surgeon. RESULTS: Of the 309,998 laparoscopic cholecystectomies during the study period, 65,295 were suitable for inclusion in the study and 13,670 (20.9%) were performed by an SQ surgeon. Patients' clinical characteristics did not differ between groups. Thirty-day mortality was significantly lower in the SQ group (0.1%) 16/13,670 than in the non-SQ group (0.2%) 140/51,625 (P = 0.001). Thirty-day mortality was [0.1% (9/7173)] in the biliary tract-qualified group, [0.2% (5/3527)] in the stomach-qualified group, and [0.1% (2/3240)] in the colon-qualified group. CONCLUSION: Surgeons with ESSQS certification outperform the non-skilled surgeons in terms of surgical mortality in 30 and 90 days. Further verification of the value of the ESSQS is warranted and similar systems may be needed in countries across the world to ensure patient safety and control the quality of surgical treatments.Aug. 2022, Surgical endoscopy, 36(8) (8), 5956 - 5963, English, International magazineScientific journal
- BACKGROUND/PURPOSE: Laparoscopic (repeat) liver resection (LRLR) is a well-established liver tumor treatment. However, since its outcomes and comparison with open repeat liver resection (ORLR) in recurrent liver cancer remain inadequately studied, this study then aimed to compare their short-term outcomes for liver cancers (hepatocellular carcinoma, intrahepatic cholangiocellular carcinoma, and metastatic liver cancer). METHODS: Repeat liver resection cases between 2013 and 2017 from Japan's National Clinical Database were extracted. We used propensity score matching (PSM) to compare the proportion of patients with postoperative complications of Clavien-Dindo classification grade II or higher (CD2+) (primary endpoint), as well as the operative time, intraoperative bleeding volume, and intraoperative transfusion implementation rate (secondary endpoints). RESULTS: Of 2902 patients (ORLR, 2476; LRLR, 426), 712 (356 per type) with comparable backgrounds remained via PSM. Before and after PSM, the postoperative CD2+ complication rate was significantly lower in the LRLR group, who had shorter operative time, smaller intraoperative bleeding volume, and lower intraoperative transfusion rate, than in the ORLR group (after matching, 7.6% vs 18.3%, P < 0.0001). CONCLUSIONS: LRLR showed better short-term outcomes than ORLR, making it a safer and more effective liver cancer treatment.Aug. 2022, Journal of hepato-biliary-pancreatic sciences, 29(8) (8), 833 - 842, English, Domestic magazineScientific journal
- PURPOSE: Despite the increasing incidence of adenocarcinoma of the esophagogastric junction, laparoscopic proximal gastrectomy with lower esophagectomy (PGLE) is not widely accepted owing to the lack of standardized reconstruction techniques. In this study, we developed a new reconstruction method named y-shaped overlap esophagogastric tube reconstruction, which reproduces an angle of His and a pseudo-fornix, to be used in laparoscopic transhiatal PGLE. This study aimed to determine the feasibility of this novel reconstruction method. METHODS: This retrospective study included the analysis of short- and mid-term surgical outcomes of 30 consecutive patients with Siewert type II esophagogastric junction adenocarcinoma who underwent laparoscopic PGLE with y-shaped overlap esophagogastric tube reconstruction from April 2015 to August 2020. A novel method was used to form a 6-cm pseudo-fornix and an angle of His using the distal esophagus and a long gastric tube. RESULTS: The median operation time was 369 min, and the median blood loss was 28 mL. The median follow-up period after surgery was 37 months. Although two patients experienced postoperative anastomotic leakage, none of the patients developed stenosis. One patient experienced moderate reflux symptoms, whereas four patients developed moderate reflux esophagitis based on the 1-year follow-up endoscopic examination; the condition of all patients could be efficiently controlled with medication. CONCLUSION: The short- and mid-term surgical outcomes of y-shaped overlap esophagogastric tube reconstruction reflected the feasibility of this simple technique and suggested its potential utility as a reconstruction alternative for Siewert type II tumors.Aug. 2022, Langenbeck's archives of surgery, 407(5) (5), 1881 - 1890, English, International magazineScientific journal
- In recent years, the usefulness of neoadjuvant chemotherapy for resectable advanced gastric cancer, particularly stage III, has been reported. Preoperative staging is mainly determined by computed tomography (CT), and the usefulness of 18F-fluoro-2-deoxyglucose positron emission tomography/CT (FDG-PET/CT) for gastric cancer has been limited in usefulness. The study aimed to evaluate the usefulness of FDG-PET/CT in preoperative diagnosis of advanced gastric cancer. We retrospectively enrolled 113 patients with gastric cancer who underwent preoperative FDG-PET/CT. All patients underwent gastrectomy with lymph-node dissection. The maximum standardized uptake value (SUVmax) of the primary tumor (T-SUVmax) and lymph nodes (N-SUVmax) were measured for all patients. The cutoff values of T-SUVmax for pathological T3/4 from receiver operating characteristic analysis were 8.28 for differentiated and 4.32 for undifferentiated types. The T-SUVmax and N-SUVmax cutoff values for pathological lymph-node metastasis were 4.32 and 1.82, respectively. Multivariate analysis showed that T-SUVmax for differentiated types was a significant predictor of pathological T3/4, and N-SUVmax was a significant predictor of lymph-node metastasis. In conclusion, the SUVmax of FDG-PET/CT was a useful predictor of pathological T3/4 and lymph-node metastasis in gastric cancer. The diagnosis by preoperative FDG-PET/CT is promising to contribute a more accurate staging of gastric cancer than by CT scan alone.Jul. 2022, Scientific reports, 12(1) (1), 11370 - 11370, English, International magazineScientific journal
- BACKGROUND: The association between weekend interventions and poor outcomes is termed the "weekend effect." This retrospective study investigated whether the weekend effect exists in the surgical treatment of acute diffuse peritonitis due to gastrointestinal perforation. METHODS: Patients (n = 16,209) who underwent operation for acute diffuse peritonitis during 2016-2017 were included and grouped depending on the perforation site. Using 23 variables, we performed hierarchical logistic regression analysis and calculated odds ratios for surgical mortality. RESULTS: Surgical mortality rates were 8.8%, 15.0%, and 14.1% for patients with gastroduodenal, small bowel, and large bowel perforations, respectively. Unadjusted odds ratios for surgical mortality differed significantly on Wednesdays only for patients with large bowel perforation (odds ratio: 0.772, 95% confidence interval: 0.613-0.972, P = 0.03). However, there was no significant difference in adjusted odds ratios. CONCLUSION: The quality of emergency surgical treatment is uniform in Japan throughout the week in terms of mortality.Jul. 2022, American journal of surgery, 224(1 Pt B) (1 Pt B), 546 - 551, English, International magazineScientific journal
- BACKGROUND: Postoperative complications affect long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC). Although a comprehensive estimator can predict long-term prognosis, the Clavien-Dindo classification system, a widely used approach to evaluate complications, assesses each complication individually. We aimed to clarify the utility of the comprehensive complication index (CCI) on predicting the overall survival (OS) of patients with ESCC following minimally invasive esophagectomy (MIE). METHODS: This was a retrospective study of patients undergoing MIE for ESCC in the prone position between January 2011 and December 2018. Multivariate analyses using the Cox proportional hazards model were performed to determine independent risk factors for OS. RESULTS: The study cohort included 229 patients who were categorized into patients with CCI values of ≥ 33.7 (CCI high) and < 33.7 (CCI low) by receiver-operating characteristic (ROC) curve analysis. There were no significant differences between the two groups according to clinicopathological factors, such as sex, age, tumor location, tumor depth, lymph node metastasis, and neoadjuvant chemotherapy. The intraoperative transfusion rate in the CCI high group was significantly higher than in the CCI low group. The 5 year OS rate was significantly lower in the CCI high group than in the CCI low group (49.5% vs. 65.7%, p = 0.030). By multivariate analyses, age, tumor depth, lymph node metastasis, and the CCI were independent predictors of OS. CONCLUSIONS: Comprehensive assessment of postoperative complications using the CCI was useful in predicting OS of patients undergoing MIE for the ESCC.Jul. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(3) (3), 410 - 416, English, Domestic magazineScientific journal
- BACKGROUND: Survivors of esophageal cancer post-esophagectomy may sometimes develop gastric tube cancer (GTC). However, its clinical characteristics have not been elucidated. We conducted a retrospective nationwide survey of GTCs to clarify them. METHODS: A questionnaire on GTCs was sent by e-mail and mail to 116 institutions certified by the Japan Esophageal Society. A total of 608 GTC cases diagnosed and treated between 2001 and 2015 were registered from 62 institutions. RESULTS: The median age at diagnosis was 71 years, with 88.9% being diagnosed with stage I. Sixty percent of GTC cases were in the anal third of the gastric tube and 79.7% were differentiated adenocarcinomas. The median interval between esophagectomy and GTC diagnosis was 6 years, with approximately 25% of patients being diagnosed more than 10 years later. The 5-year overall survivals (5-OSs) after endoscopic and surgical treatments for GTC were 75.9% and 52.7%, respectively. Patients whose GTC was diagnosed without symptoms or by regular follow-up examination showed better 5-OSs compared to others (69.7% vs. 41.2%, p < 0.0001; and 71.4% vs. 41.8%, p < 0.0001, respectively). The prognosis of GTC cases diagnosed within 2 years of the preceding upper gastrointestinal endoscopy (UGI) was better than that in cases diagnosed longer than 2 years (5-OS: 73.4% vs. 48.8%, p < 0.05). CONCLUSION: This nationwide survey revealed the clinicopathological features of GTCs for the first time. Early detection is important in improving the prognosis of GTC, and it is recommended that UGI endoscopy be continued every 2 years for 10 or more years after esophagectomy.Jul. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(3) (3), 384 - 392, English, Domestic magazineScientific journal
- (株)南江堂, Jun. 2022, 外科, 84(7) (7), 715 - 718, Japanese
- PURPOSE: Centralization of high-risk surgeries has become a widespread strategy. However, whether or not the hospital volume affects the outcomes of common surgeries remains unclear. This study explored the association between hospital volume and short-term outcomes of common surgeries, as represented by appendectomy, cholecystectomy, and pneumothorax surgery, by analyzing data from a Japanese nationwide database. METHODS: All hospitals were categorized into four groups (very low-, low-, high-, and very high-volume) according to the annual hospital volume of all gastrointestinal surgeries or all respiratory surgeries in 2017. Patient demographic data and surgical outcomes were evaluated across hospital volume categories. RESULTS: We analyzed 2392 facilities which performed 771,182 gastrointestinal surgeries, and 992 facilities which performed 98,656 respiratory surgeries. Short-term outcomes of patients who underwent appendectomy (n = 50,568), cholecystectomy (n = 104,262), and pneumothorax surgery (n = 11,723) were evaluated. The incidences of postoperative complications, reoperation, and readmission were similar among the groups. Multivariable logistic regression analyses revealed hospital volume to have no association with these short-term outcomes. CONCLUSION: Analyses of a Japanese nationwide database revealed that the hospital volume was not associated with short-term outcomes of appendectomy, cholecystectomy, and pneumothorax surgery. These common surgical procedures may not require centralization into high-volume hospitals.Jun. 2022, Surgery today, 52(6) (6), 941 - 952, English, Domestic magazineScientific journal
- BACKGROUND: Minimally invasive esophagectomy (MIE) for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; however, the relationship between sarcopenia and the survival of esophageal cancer patients remains controversial. In this study, we aimed to develop a stratifying marker for sarcopenia to precisely predict patients' prognosis. METHODS: We retrospectively studied 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were preoperatively diagnosed with or without sarcopenia based on the Asian Working Group for Sarcopenia index. Creatinine levels and albumin as measures of skeletal muscle volume and nutritional status, respectively, were used to develop a marker to be used for stratifying sarcopenic patients based on prognosis. RESULTS: Of the 135 patients, 35 were diagnosed with sarcopenia and 100 were not. We combined the creatinine and albumin levels (Cr × Alb) as a stratifying marker for sarcopenia, and extracted sarcopenic patients with values below the Cr × Alb cut-off as the actual sarcopenic group. The 5-year overall survival (OS) rates of the actual and non-actual sarcopenic groups were 28.9% and 58.9%, respectively (p = 0.0005), and the 5-year disease-free survival rate of the actual sarcopenic group was 34.1%, and 62.8% (p = 0.0106) for the non-actual sarcopenic group. This stratified sarcopenia model was an independent prognostic factor and was superior to sarcopenia alone for OS. CONCLUSIONS: In patients undergoing MIE, preoperative measurement of Cr × Alb may be a prognostic stratification marker for patients with sarcopenia.Jun. 2022, Annals of surgical oncology, 29(6) (6), 3670 - 3681, English, International magazineScientific journal
- BACKGROUND: MicroRNAs (miRNAs) are key regulators of stem cell functions, including self-renewal and differentiation. In this study, we aimed to identify miRNAs that are upregulated during terminal differentiation in the human colon epithelium, and elucidate their role in the mechanistic control of stem cell properties. METHODS: "Bottom-of-the-crypt" (EPCAM+/CD44+/CD66alow) and "top-of-the-crypt" (EPCAM+/CD44neg/CD66ahigh) epithelial cells from 8 primary colon specimens (6 human, 2 murine) were purified by flow cytometry and analyzed for differential expression of 335 miRNAs. The miRNAs displaying the highest upregulation in "top-of-the-crypt" (terminally differentiated) epithelial cells were tested for positive correlation and association with survival outcomes in a colon cancer RNA-seq database (n = 439 patients). The two miRNAs with the strongest "top-of-the-crypt" expression profile were evaluated for capacity to downregulate self-renewal effectors and inhibit in vitro proliferation of colon cancer cells, in vitro organoid formation by normal colon epithelial cells and in vivo tumorigenicity by patient-derived xenografts (PDX). RESULTS: Six miRNAs (miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-345) were upregulated in "top-of-the-crypt" cells and positively correlated in expression among colon carcinomas. Overexpression of the three miRNAs with the highest inter-correlation coefficients (miR-200a, miR-200b, miR-200c) associated with improved survival. The top two over-expressed miRNAs (miR-200c, miR-203) cooperated synergistically in suppressing expression of BMI1, a key regulator of self-renewal in stem cell populations, and in inhibiting proliferation, organoid-formation and tumorigenicity of colon epithelial cells. CONCLUSION: In the colon epithelium, terminal differentiation associates with the coordinated upregulation of miR-200c and miR-203, which cooperate to suppress BMI1 and disable the expansion capacity of epithelial cells.Jun. 2022, Journal of gastroenterology, 57(6) (6), 407 - 422, English, Domestic magazineScientific journal
- Intestinal metaplasia is related to gastric carcinogenesis. Previous studies have suggested the important role of CDX2 in intestinal metaplasia, and several reports have shown that the overexpression of CDX2 in mouse gastric mucosa caused intestinal metaplasia. However, no study has examined the induction of intestinal metaplasia using human gastric mucosa. In the present study, to produce an intestinal metaplasia model in human gastric mucosa in vitro, we differentiated human-induced pluripotent stem cells (hiPSC) to gastric organoids, followed by the overexpression of CDX2 using a tet-on system. The overexpression of CDX2 induced, although not completely, intestinal phenotypes and the enhanced expression of many, but not all, intestinal genes and previously reported intestinal metaplasia-related genes in the gastric organoids. This model can help clarify the mechanisms underlying intestinal metaplasia and carcinogenesis in human gastric mucosa and develop therapies to restitute precursor conditions of gastric cancer to normal mucosa.May 2022, iScience, 25(5) (5), 104314 - 104314, English, International magazineScientific journal
- Although transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.May 2022, Annals of surgical oncology, 29(5) (5), 3065 - 3065, English, International magazineScientific journal
- Accumulating evidence demonstrates that bone marrow (BM)-derived mesenchymal stem cells (MSCs) play critical roles in regulating progression of various types of cancer. We have previously shown that Wnt5a-Ror2 signaling in MSCs induces expression of CXCL16, and that CXCL16 secreted from MSCs then binds to its cognate receptor CXCR6 on the surface of an undifferentiated gastric cancer cell line MKN45 cells, eventually leading to proliferation and migration of MKN45 cells. However, it remains unclear about a possible involvement of another (other) cytokine(s) in regulating progression of gastric cancer. Here, we show that CXCL16-CXCR6 signaling is also activated in MSCs through cell-autonomous machinery, leading to upregulated expression of CCL5. We further show that CCR1 and CCR3, receptors of CCL5, are expressed on the surface of MKN45 cells, and that CCL5 secreted from MSCs promotes migration of MKN45 cells presumably via its binding to CCR1/CCR3. These data indicate that cell-autonomous CXCL16-CXCR6 signaling activated in MSCs upregulates expression of CCL5, and that subsequent activation of CCL5-CCR1/3 signaling in MKN45 cells through intercellular machinery can promote migration of MKN45 cells. Collectively, these findings postulate the presence of orchestrated chemokine signaling emanated from MSCs to regulate progression of undifferentiated gastric cancer cells.May 2022, Genes to cells : devoted to molecular & cellular mechanisms, 27(5) (5), 368 - 375, English, International magazineScientific journal
- BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). PATIENTS AND METHODS: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). RESULTS: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR ≥169.6 had worse 5-year OS rates (31.1%) than those with a PLR <169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of ≥169.6 was an independent factor for poor prognosis. CONCLUSION: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.May 2022, Anticancer research, 42(5) (5), 2775 - 2782, English, International magazineScientific journal
- Background: Elective laparoscopic surgery is now widely accepted in the treatment of abdominal diseases because of its minimal invasiveness and rapid postoperative recovery. It is also used in the emergency setting for the diagnosis and treatment of acute diffuse peritonitis regardless of the causative disease. However, the value of laparoscopy in acute diffuse peritonitis remains unclear. In this study we aimed to show trends in the use of laparoscopy over time and compare the real-world performance of laparoscopic surgery with that of open surgery for acute diffuse peritonitis due to gastrointestinal perforation. Methods: We extracted data from the National Clinical Database, a nationwide surgery registration system in Japan, for patients with a diagnosis of acute diffuse peritonitis due to gastroduodenal or colorectal perforation between 2016 and 2019. Trends in the use of laparoscopy over time were identified. Patient characteristics, laboratory findings, surgical findings, and postoperative complications were compared between laparoscopic surgery and open surgery. Results: Patients in poor condition and those with abnormal laboratory findings tended to undergo open surgery. Anesthesia time and operating time were longer for laparoscopic surgery in patients with gastroduodenal perforation but shorter in those with colorectal perforation. Fewer complications occurred in patients who underwent laparoscopic surgery. The number of institutions where laparoscopic surgery was performed and the proportion of the use of laparoscopy at each institution increased over time. Conclusion: The use of laparoscopy is becoming common in surgery for acute diffuse peritonitis due to gastrointestinal perforation. This approach may be a useful option for acute diffuse peritonitis.May 2022, Annals of gastroenterological surgery, 6(3) (3), 430 - 444, English, Domestic magazineScientific journal
- (一社)日本外科学会, Apr. 2022, 日本外科学会定期学術集会抄録集, 122回, SP - 8, Japanese外科医獲得にむけた神戸大学外科学講の取り組み
- Mar. 2022, Diseases of the colon and rectum, 65(3) (3), e175, English, International magazineScientific journal
- BACKGROUND/AIM: This study aimed to examine the efficacy of surgical intervention after chemotherapy for stage IV gastric cancer and the predictors of survival after surgical intervention. PATIENTS AND METHODS: Forty-three gastric cancer patients who had only one type of incurable factor (e.g., para-aortic lymph node metastasis) and had undergone initial chemotherapy, underwent chemotherapy alone (CX group; n=25), palliative gastrectomy (PS group; n=8), and conversion surgery (CS group; n=10). Their therapeutic outcomes were compared. RESULTS: The CS group had significantly higher 2-year overall survival rates (80%) than the CX group (25%), whose prognosis was similar to that of the PS group (23%; p<0.001). Pathological complete response of para-aortic lymph node or peritoneal metastases was an independent predictor of survival after surgery, as was >6 months of chemotherapy. CONCLUSION: CS may improve the prognosis of patients with stage IV gastric cancer in whom chemotherapy can achieve pathological disappearance of the metastatic lesions.Mar. 2022, Anticancer research, 42(3) (3), 1541 - 1546, English, International magazineScientific journal
- Background and Aim: In Japan, the actual number of stoma constructions and stoma closures is not known. The aim of this study was to conduct a survey to determine the number of gastrointestinal stoma constructions and closures in Japan. Methods: Enrolled participants comprised patients undergoing selected gastrointestinal surgeries who were recorded in the National Clinical Database. This database uses the "Common Items for Gastrointestinal Surgeons." These procedures were formulated by the Japanese Society of Gastroenterological Surgery during 2013-2018. Results: According to the National Clinical Database, a total of 154,323 gastrointestinal stomas were constructed between January 1, 2013 and December 31, 2018. By procedure, there were 78,723 cases of stoma construction, 39,653 of abdominoperineal resection, 2470 total pelvic exenteration procedures, and 33,572 Hartmann's procedures. The ratio of stoma closures to stoma constructions increased annually in patients under 70 y of age but not in older patients. Approximately 35% of total colectomies, 60% of proctocolectomies, and 20% of low anterior resections were accompanied by stoma construction. The number of patients with rectal cancer who underwent colostomy increased gradually during the study period and the number who underwent stoma construction increased among older patients. Conclusion: The number of cases of gastrointestinal stoma construction has increased gradually in Japan, and the proportion of older patients is increasing each year. The purposes and surgical techniques for stoma construction are diverse and are expected to increase in Japan, a super-aged society.Mar. 2022, Annals of gastroenterological surgery, 6(2) (2), 212 - 226, English, Domestic magazineScientific journal
- Feb. 2022, GI Cancer Cutting Edge, 3(3) (3), 6, Japanese進行胃がんに対する腹腔鏡下幽門側胃切除術の長期成績-KLASS-02試験-Scientific journal
- BACKGROUND: This study aimed to identify prognostic factors for adenocarcinoma of the esophagogastric junction (AEG) in Siewert type II and characterize the population whose prognosis is expected to improve. PATIENTS AND METHODS: We retrospectively reviewed a database of 68 AEG type II patients who had undergone surgical curative resection without preoperative treatment. RESULTS: Although patients with pathological N0 (pN0) showed favorable 3-year disease-free survival (91%), patients with pN1-3 had poor outcomes (42%, 23%, and 10%). Multivariate analyses showed that the only independent prognostic factor was lymph node metastasis, and that tumor depth (cT3-4) and tumor size (≥4 cm) were correlated closely with lymph node metastasis. CONCLUSION: Surgical curative resection without preoperative treatment is insufficient to treat AEG type II with lymph node metastasis. Among AEG patients, those with the high-risk factors of preoperative tumor depth (T3-4) or/and size (≥4 cm) might need intensive multimodal treatment, including perioperative adjuvant chemotherapy.Feb. 2022, Anticancer research, 42(2) (2), 1051 - 1057, English, International magazineScientific journal
- Feb. 2022, Endoscopy international open, 10(2) (2), E226, English, International magazineScientific journal
- Jan. 2022, Annals of surgical oncology, English, International magazineScientific journal
- BACKGROUND/AIM: The safety of gastrectomy for patients receiving antithrombotic agents remains unclear. This retrospective cohort study sought to compare outcomes between patients who did and did not receive antithrombotic agents. PATIENTS AND METHODS: This single-center retrospective cohort study included 548 patients who underwent gastrectomy for primary gastric adenocarcinoma from January 2011 to December 2019. The surgical outcomes were compared between two groups according to whether they received antithrombotic therapy (n=121) or not (n=427). RESULTS: Among the entire cohort, the patients in the antithrombotic therapy group were significantly older than those who did not receive this therapy and had significantly higher postoperative complication rates than those who did not (33.1% vs. 23.9%; p=0.046). However, after propensity score matching, no significant difference in the postoperative complication rate was observed between the two groups. CONCLUSION: Despite having a high risk for postoperative complications, patients receiving antithrombotic therapy can safely undergo gastric resection.2022, Cancer diagnosis & prognosis, 2(2) (2), 210 - 215, English, International magazineScientific journal
- INTRODUCTION: The drain amylase concentration (dAmy-C) is a useful marker for predicting pancreatic fistula after gastric cancer surgery. However, dAmy-C might be reduced in cases of high drainage volume. Therefore, we hypothesized that we could accurately assess the amount of amylase leaked from the pancreas by multiplying dAmy-C by the daily drainage volume. In this study, we investigated the clinical utility of the amount of drain amylase (A-dAmy: concentration × volume) for predicting pancreatic fistula. We investigated the clinical utility of the combination of dAmy-C and A-dAmy for predicting pancreatic fistula. METHODS: We investigated patients who underwent gastrectomy for gastric cancer at Yodogawa Christian Hospital between 2012 and 2020. The optimal cutoff levels of dAmy-C and A-dAmy on postoperative day 1 for predicting Clavien-Dindo (CD) grade II or higher pancreatic fistula was calculated using receiver operating characteristic (ROC) curves. We calculate the positive predictive value and negative predictive value for predicting pancreatic fistula using these cutoff levels. RESULTS: A total of 448 patients were eligible for analysis. Twenty-two patients experienced CD grade II or higher pancreatic fistula. ROC curves identified 1,615 IU/L as the optimal cutoff level of dAmy-C, predicting pancreatic fistula. When the simple cutoff level of dAmy-C was 1,600 IU/L, the positive predictive value for was 22.8%, and the negative predictive value was 99.7%. ROC curves identified 177.52 IU as the optimal cutoff level of A-dAmy predicting pancreatic fistula. When the simple cutoff level of A-dAmy was 177 IU, the positive predictive value was 21.2%, and the negative predictive value was 99.7%. Using these two cutoff levels together, the positive predictive value was 34.4%, and the negative predictive value was 99.7%. CONCLUSION: A-dAmy could predict and exclude pancreatic fistula after gastrectomy as with dAmy-C. The combination of dAmy-C and A-dAmy predict pancreatic fistula more accurately than dAmy-C alone.2022, Oncology, 100(7) (7), 363 - 369, English, International magazineScientific journal
- Situs inversus totalis (SIT) is a rare condition in which the internal organ's position is a mirror image of normal anatomy. Although several investigators reported laparoscopic surgery for colorectal cancer in patients with SIT, it is considered difficult even for an experienced surgeon because of the mirror position. We show a case report of laparoscopic sigmoidectomy with the splenic flexure mobilization (SFM) procedure in SIT. A 79-year-old woman with SIT was referred to our hospital for a locally advanced sigmoid cancer (cT3N1M0, cStageIIIB). We safely performed the laparoscopic sigmoidectomy with SFM, as shown in detail below. No postoperative complication occurred, and the patient is in good health with no recurrences 30 months after surgery, as of the writing this report. We propose three critical points; checking the CT angiography to understand the anatomy; using flip-horizontal video of "normal" laparoscopic sigmoidectomy to confirm an unfamiliar situation; adding the epigastric trocar to make SFM procedures safe and comfortable.Jan. 2022, Asian journal of endoscopic surgery, 15(1) (1), 168 - 171, English, Domestic magazine
- BACKGROUND: Surgical treatment is usually required for Boerhaave's syndrome (post-emetic esophageal perforation), and the technique should be chosen based on the local infection status and patient's general condition. This study was performed to examine the current status of surgical treatment of Boerhaave's syndrome in Japan. METHODS: Ninety-five patients with Boerhaave's syndrome who underwent surgical treatment from January 2010 to December 2015, obtained from a national survey were retrospectively analyzed. The details of each surgical treatment and the type of treatment performed according to the patients' characteristics were examined. RESULTS: Primary closure was performed in 75 (78.9%) patients, T-tube insertion in 15 (15.8%), and esophagectomy in 5 (5.3%). The length of the postoperative stay was significantly shorter in patients who underwent primary closure (p = 0.0011). Esophagectomy tended to be performed more often in patients with a long perforation and was performed significantly more often in patients with a high C-reactive protein concentration (p = 0.0118). The postoperative hospital stay was significantly longer in patients with leakage of the primary closure site (p < 0.0001). As a result, leakage of the primary closure site was significantly correlated with a long duration from symptom onset to patient presentation (p = 0.042), diagnostic imaging of the intrathoracic perforation (p = 0.013), and abscess formation in the mediastinal cavity (p = 0.006). CONCLUSIONS: Selection of an appropriate surgical procedure may contribute to reduced mortality rates in patients with esophageal rupture. With regard to primary closure, it is necessary to understand that leaks are likely to occur in patients with a long duration from symptom onset to presentation or with severe intrathoracic/mediastinal inflammation, and to select an appropriate surgical procedure in consideration of the degree of invasiveness and QOL.Jan. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(1) (1), 175 - 181, English, Domestic magazineScientific journal
- BACKGROUND: Several studies have reported the efficacy of resection for recurrent lesions. However, they involved a limited number of subjects. This study aimed to identify a subset of patients who benefit from surgical resection of recurrent lesions after curative esophagectomy for esophageal squamous cell carcinoma. METHODS: Clinicopathological features of 186 patients with esophageal squamous cell carcinoma who underwent surgical treatment for postoperative recurrent lesions at 37 accredited institutions of the Japanese Esophageal Society were evaluated. RESULTS: The most common recurrence site was the lymph node (106 cases; 58.6%), followed by the lung (40 cases; 22.1%). Univariate analyses revealed that pN 0-1 at esophagectomy (P = 0.0348), recurrence-free interval of ≥ 550 days (P = 0.0306), R0 resection (P < 0.0001), and absence of severe complications after resection for recurrent lesions (Clavien-Dindo grade < IIIa) (P = 0.0472) were associated with better overall survival after surgical resection. According to multivariate analyses, pN 0-1 (P = 0.0146), lung metastasis (P = 0.0274), recurrence-free interval after curative esophagectomy of ≥ 550 days (P = 0.0266), R0 resection (P = 0.0009), and absence of severe complications after resection for recurrent lesions (Clavien-Dindo grade < IIIa) (P = 0.0420) were independent predictive factors for better overall survival. CONCLUSIONS: Surgical resection of recurrent esophageal squamous cell carcinoma lesions is a useful option, especially for cases involving lower pN stage, lung metastasis, long recurrence-free intervals after esophagectomy, and technically resectable lesions. Surgical risks should be minimized as much as possible.Jan. 2022, Esophagus : official journal of the Japan Esophageal Society, 19(1) (1), 57 - 68, English, Domestic magazineScientific journal
- (1) Background: Cancer vaccines are administered to induce cytotoxic CD8+ T cells (CTLs) specific for tumor antigens. Invariant natural killer T (iNKT) cells, the specific T cells activated by α-galactosylceramide (α-GalCer), play important roles in this process as they are involved in both innate and adaptive immunity. We developed a new cancer vaccine strategy in which dendritic cells (DCs) were loaded with an exogenous ovalbumin (OVA) protein by electroporation (EP) and pulsed with α-GalCer. (2) Methods: We generated bone marrow-derived DCs from C57BL/6 mice, loaded full-length ovalbumin proteins to the DCs by EP, and pulsed them with α-GalCer (OVA-EP-galDCs). The OVA-EP-galDCs were intravenously administered to C57BL/6 mice as a vaccine. We then investigated subsequent immune responses, such as the induction of iNKT cells, NK cells, intrinsic DCs, and OVA-specific CD8+ T cells, including tissue-resident memory T (TRM) cells. (3) Results: The OVA-EP-galDC vaccine efficiently rejected subcutaneous tumors in a manner primarily dependent on CD8+ T cells. In addition to the OVA-specific CD8+ T cells both in early and late phases, we observed the induction of antigen-specific TRM cells in the skin. (4) Conclusions: The OVA-EP-galDC vaccine efficiently induced antigen-specific antitumor immunity, which was sustained over time, as shown by the TRM cells.Dec. 2021, Cancers, 14(1) (1), English, International magazineScientific journal
- Tumor-associated macrophages are associated with more malignant phenotypes of esophageal squamous cell carcinoma (ESCC) cells. Previously, using an indirect co-culture assay of ESCC cells and macrophages, the authors identified several factors associated with ESCC progression. Here, a direct co-culture assay of ESCC cells and macrophages was established, which more closely simulated the actual cancer microenvironment. Direct co-cultured ESCC cells had significantly increased migration and invasion abilities, and phosphorylation levels of Akt and p38 mitogen-activated protein kinase (MAPK) compared with monocultured ESCC cells. According to a cDNA microarray analysis between monocultured and co-cultured ESCC cells, both the expression and release of S100 calcium binding protein A8 and A9 (S100A8 and S100A9), which commonly exist and function as a heterodimer (herein, S100A8/A9), were significantly enhanced in co-cultured ESCC cells. The addition of recombinant human S100A8/A9 protein induced migration and invasion of ESCC cells via Akt and p38 MAPK signaling. Both S100A8 and S100A9 silencing suppressed migration, invasion, and phosphorylation of Akt and p38 MAPK in co-cultured ESCC cells. Moreover, ESCC patients with high S100A8/A9 expression exhibited significantly shorter disease-free survival (P = 0.005) and cause-specific survival (P = 0.038). These results suggest that S100A8/A9 expression and release in ESCC cells are enhanced by direct co-culture with macrophages and that S100A8/A9 promotes ESCC progression via Akt and p38 MAPK signaling pathways.Dec. 2021, The American journal of pathology, 192(3) (3), 536 - 552, English, International magazineScientific journal
- OBJECTIVE: To clarify whether routine thoracic duct (TD) resection improves the prognosis of patients with esophageal cancer after radical esophagectomy. SUMMARY BACKGROUND DATA: Although TD resection can cause nutritional disadvantage and immune suppression, it has been performed for the resection of surrounding lymph nodes. METHODS: We analyzed 12,237 patients from the Comprehensive Registry of Esophageal Cancer in Japan who underwent esophagectomy between 2007 and 2012. TD resection and preservation groups were compared in terms of prognosis, perioperative outcomes, and initial recurrent patterns using strict propensity score matching. Particularly, the year of esophagectomy and history of primary cancer of other organs were added as covariates. RESULTS: Following propensity score matching, 1638 c-Stage I-IV patients participated in each group. The five-year overall survival and cause-specific survival rates were 57.5% and 55.2% in the TD-resected group and 65.6% and 63.4% in the TD-preserved group, respectively, without significant differences. The TD-resected group had significantly more retrieved mediastinal nodes (30 vs. 21, P < 0.0001) and significantly fewer lymph node recurrence (376 vs. 450, P = 0.0029) compared with the TD-preserved group. However, the total number of distant metastatic organs was significantly greater in TD-resected group than in the TD-preserved group (499 vs. 421, P = 0.0024). CONCLUSIONS: TD resection did not improve survival in patients with esophageal cancer. Despite having retrieved more lymph nodes, TD resection caused distant metastases in more organs compared to TD preservation. Hence, prophylactic TD resection should not be recommended in patients with esophageal cancer.Dec. 2021, Annals of surgery, English, International magazineScientific journal
- BACKGROUND: Despite the increasing utilization of transanal total mesorectal excision as a promising approach for low rectal cancer, the feasibility and safety of transperineal minimally invasive abdominoperineal resection (tp-APR) remain unclear. METHODS: In total, 25 patients who underwent tp-APR between April 2017 and May 2020 (tp-APR group) and 27 patients who underwent conventional laparoscopic APR between May 2009 and September 2016 (lap-APR group) for low rectal cancer were enrolled in this retrospective study. Clinical outcomes were compared between the groups before and after propensity score matching. The primary outcome was the incidence of the overall postoperative complications with Clavien-Dindo grade II or above. Standardized technique of tp-APR was also demonstrated. RESULTS: On comparison, operative time, intraoperative blood loss, and overall postoperative complications with Clavien-Dindo grade II or above were significantly less in the tp-APR group both before and after propensity score matching. The rates of urinary disturbance and perineal wound infection were significantly less in the tp-APR group after matching. Further, postoperative hospital stay was significantly shorter in the tp-APR group both before and after matching. However, pathological outcomes did not differ between the groups before and after matching. There has been no local recurrence in the tp-APR group with a median follow-up period of 18 months. CONCLUSION: Standardized tp-APR for low rectal cancer is feasible and seems superior to conventional laparoscopic APR in terms of short-term outcomes. Further larger-scale studies with a longer follow-up period are required to evaluate oncological outcomes.Dec. 2021, Surgical endoscopy, 35(12) (12), 7236 - 7245, English, International magazineScientific journal
- BACKGROUND: One of the primary treatment for resectable advanced esophageal squamous cell cancer (ESCC) is neoadjuvant chemotherapy (NAC) followed by minimally invasive esophagectomy (MIE). Because the neutrophil-to-lymphocyte ratio (NLR) is a widely reported prognostic factor in several cancers, we investigated whether the preoperative NLR is a biomarker in ESCC patients treated with NAC and MIE. METHODS: In this study, we investigated 174 ESCC patients who underwent MIE from January 2010 to December 2015, including 121 patients who received NAC. The cutoff value of the NLR was analyzed using the receiver operating characteristic curve. Multivariate analyses were performed to clarify independent prognostic factors for overall survival (OS). RESULTS: The cutoff value of the NLR for OS in 121 patients who received NAC was 2.5 ng/ml, and the area under the curve was 0.63026 (p = 0.0127). The 5-year OS rate was 64% in those with an NLR <2.5 and 39% in those with an NLR ≥2.5. According to multivariate analysis, NLR ≥2.5, pathological T, pathological N, and intraoperative blood loss of >415 ml were independent poor prognostic factors. CONCLUSIONS: NLR is a biomarker of prognosis in ESCC patients who undergo MIE after NAC.Dec. 2021, Journal of surgical oncology, 124(7) (7), 1022 - 1030, English, International magazineScientific journal
- INTRODUCTION: Although lateral pelvic lymph node dissection is considered as a treatment option for advanced rectal cancer, it is technically demanding. Recently, the transanal approach for total mesorectal excision has become increasingly used. In this Technical Note, we describe lateral pelvic lymph node dissection using a 2-team method that was assisted by the transanal approach. TECHNIQUE: First, the lateral pelvic area was entered from the anal side by dissection between the S4 sacral splanchnic nerve and levator ani muscle. Then, the fatty tissues including the obturator compartment and the distal part of the internal iliac compartment were separated from the inferior and superior vesical vessels and the bladder wall. Next, the fatty tissues were separated from the lateral pelvic wall. The obturator nerve was isolated and preserved, whereas the obturator vessels were resected at their peripheral end. Then, the fatty tissues were dissected from the bottom plane. Finally, the fatty tissues were dissected from the ventral bladder wall and were completely isolated from the obturator nerve in cooperation with the transabdominal team. RESULTS: The 2-team method shortened the operative time dramatically and decreased mental and physical burden on the operators during lateral dissection. Assistance with the transanal approach helped with a secure and effective dissection, especially of the most distal parts, such as around the internal pudendal and inferior vesical arteries, because substantial skill is required for the transabdominal approach alone. CONCLUSIONS: This procedure is useful for the safe and effective performance of lateral pelvic lymph node dissection for patients with rectal cancer.Dec. 2021, Diseases of the colon and rectum, 64(12) (12), e719-e724, English, International magazineScientific journal
- BACKGROUND: Multidisciplinary treatment for esophageal squamous cell carcinoma (ESCC) has improved outcomes, but the prognosis for ESCC remains poor. Nutritional and inflammatory indicators are reported to be associated with cancer prognosis. The combination of albumin and the derived neutrophil-to-lymphocyte ratio (Alb-dNLR) score was established to measure the immune system and nutritional status. The authors hypothesized that the Alb-dNLR score could be a new reliable prognostic factor for ESCC patients. METHODS: The study evaluated 269 patients who underwent esophagectomy between April 2010 and March 2018, including 185 patients who received neoadjuvant chemotherapy. The Alb-dNLR score was calculated using serum albumin and the dNLR. The dNLR was calculated as neutrophils to (leukocyte-neutrophil count). The cutoff values of the albumin and dNLR for overall survival (OS) were determined using the receiver operating characteristic curve. Patients were divided into "high" and "low" groups according to the Alb-dNLR score. RESULTS: A high Alb-dNLR score was found in 61 cases (22.7%). The 5-year OS was 34% in the high Alb-dNLR group and 66.2% in the low Alb-dNLR group (p < 0.0001). The 5-year cause-specific survival (CSS) was 51.5% in the high Alb-dNLR group and 74.7% in the low Alb-dNLR group (p < 0.0001). Multivariate analyses demonstrated that the Alb-dNLR score was an independent prognostic factor for OS (hazard ratio [HR], 2.198; 95% confidence interval [CI], 1.460-3.263; p = 0.0002) and CSS (HR, 1.733; 95% CI, 1.035-2.835; p = 0.0371). CONCLUSIONS: The Alb-dNLR score is an extremely useful, easy-to-use parameter to predict OS and CSS for ESCC patients.Nov. 2021, Annals of surgical oncology, 29(4) (4), 2663 - 2671, English, International magazineScientific journal
- BACKGROUND: Whether surgical device usage in laparoscopic gastrectomy differs with respect to operator's skill levels is unknown. Further, device usage analysis using artificial intelligence has not been reported to date. Herein, we compared the patterns of surgical device usage during laparoscopic gastrectomy for gastric cancer among surgeons at different skill levels. The data of device usage was acquired from laparoscopic video recordings using an automated surgical-instrument detection system. METHODS: In total, 100 video recordings of infrapyloric lymphadenectomy and 33 of D2 suprapancreatic lymphadenectomy during laparoscopic gastrectomy for gastric cancer were analyzed in this retrospective study. The system's accuracy was evaluated by comparing the automatic and the manual usage time. Surgical device usage patterns were compared between qualified and nonqualified surgeons of The Japan Society for Endoscopic Surgery Endoscopic Surgical Skill Qualification System. RESULTS: For every device, the automatic detection time and manual detection time were consistent with each other. In infrapyloric lymphadenectomy, the usage time proportions of dissector forceps and clip applier were higher among nonqualified operators than among qualified operators (dissector, 5.1% vs. 2.3%, P < 0.001; clip applier, 1.6% vs. 1.3%, P < 0.01). In suprapancreatic lymphadenectomy, the usage time proportions of energy devices, clip applier, and grasper forceps were significantly different (energy devices, 59.6% vs. 50.6%, P < 0.001; clip applier, 1.4% vs. 0.9%, P < 0.001; only grasper forceps; 18.3% vs. 27.9%, P = 0.022). CONCLUSIONS: Quantitative analysis of laparoscopic device usage using the automated surgical device detection system showed that the patterns of device usage during laparoscopic gastrectomy differed depending on surgeons' skill levels. These differences could suggest how the qualified and nonqualified surgeons performed the procedures.Nov. 2021, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(5) (5), 1006 - 1014, English, International magazineScientific journal
- (一社)日本外科学会, Nov. 2021, 日本外科学会雑誌, 122(6) (6), 719 - 721, Japanese各疾患登録とNCDの課題と将来 胃がん登録の現状とNCDへの実装
- Nov. 2021, Annals of surgical oncology, 28(12) (12), 7258 - 7258, English, International magazineScientific journal
- BACKGROUND: Esophagectomy with lymphadenectomy is the principal treatment for localized esophageal cancer. Conventional minimally invasive esophagectomy (C-MIE) in prone position has spread worldwide as it is less invasive. However, its efficacy remains controversial. Robot-assisted MIE (RAMIE) can have more advantages than C-MIE. Therefore, the current study aimed to validate whether RAMIE is associated with lower incidence of left recurrent laryngeal nerve (RLN) palsy compared with C-MIE in prone position. PATIENTS AND METHODS: In total, 404 patients with esophageal carcinoma underwent MIE (353 C-MIEs and 51 RAMIEs) in prone position at Kobe University between 2010 and 2020. Then, propensity score matching was performed, and results showed that 51 patients should be included in each group. Thereafter, the perioperative outcomes between the two groups were compared. RESULTS: The RAMIE group had a significantly longer operative time than the C-MIE group (P < 0.0001). However, the number of lymph nodes resected along the left RLN was similar in both groups. Moreover, the incidence of left RLN palsy was significantly lower in the RAMIE group than in the C-MIE [Clavien-Dindo classification grade II; 0 (0%) versus 32 (9%), P = 0.022 in entire cohort, and 0 (0%) versus 5 (10%), P = 0.022 in matched cohort. Esophagectomy Complications Consensus Group definitions type I; 8 (16%) versus 101 (29%), P = 0.041 in entire cohort and 8 (16%) versus 18 (35%) in matched cohort, P = 0.023]. CONCLUSION: RAMIE is superior to C-MIE in prone position in decreasing the incidence of left RLN palsy.Nov. 2021, Annals of surgical oncology, 28(12) (12), 7249 - 7257, English, International magazineScientific journal
- PURPOSE: There has been an increase in the percentage of elderly patients with colorectal cancer (CRC). However, few studies have reported the short- and long-term outcomes of laparoscopic surgery for elderly patients with CRC aged over 80 years. METHODS: This study included 529 patients who underwent laparoscopic resection for clinical stage 0-III CRC at Kobe University Hospital between January 2010 and December 2018. Propensity score matching (PSM) was used to create balanced cohorts of the elderly (aged ≥ 80, n = 113) and the non-elderly (aged < 80, n = 113). Their clinical outcomes were compared after PSM. RESULTS: After matching, carcinoembryonic antigen (CEA) level was higher in the non-elderly group, and adjuvant chemotherapy was less frequently employed in the elderly group. D3 dissection was performed more frequently and the number of the harvested lymph nodes tended to be larger in the non-elderly group. There was no significant difference in the rates of postoperative complications, reoperation within 30 days, and 30-day mortality between the groups. The 5-year relapse-free survival rate was not statistically different between the two groups (77.3% for the non-elderly vs. 62.7% for the elderly, p = 0.13). The multivariate analyses for the whole cohort showed that the factors of sex, tumor location, operation time, and conversion to open surgery, but not the age, were significant predictors of postoperative complications. CONCLUSION: Laparoscopic surgery for colorectal cancer patients aged over 80 years is technically and oncologically safe.Nov. 2021, International journal of colorectal disease, 36(11) (11), 2519 - 2528, English, International magazineScientific journal
- BACKGROUND: Lateral pelvic lymph node metastasis impairs the oncological outcomes of patients with rectal cancer. Although lateral pelvic lymph node dissection (LLND) might be an effective procedure for such patients, the associated risk factors for postoperative complications are unknown. PATIENTS AND METHODS: The operative outcomes of 21 patients undergoing unilateral LLND and 26 patients undergoing bilateral LLND for rectal cancer were compared. The risk factors for complications were evaluated using a logistic regression model. RESULTS: Univariate and multivariate analyses revealed that a longer operative time (≥480 min) was the most important risk factor for grade II or more postoperative complications according to the Clavien-Dindo classification (odds ratio=6.58; 95% confidence interval=1.35-32.1; p=0.020). A bilateral procedure was not a significant risk factor for postoperative complications. CONCLUSION: Surgeons should make efforts to shorten the operative time to reduce the risk of postoperative complications.Nov. 2021, Anticancer research, 41(11) (11), 5599 - 5604, English, International magazineScientific journal
- INTRODUCTION: Recently, sarcopenia has been reported to be associated with poor postoperative outcomes in various cancers. However, its clinical significance for rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT) followed by surgery remains unknown. MATERIALS AND METHODS: This study included 46 patients with locally advanced rectal cancer who underwent curative surgery after NACRT. Sarcopenia was assessed by measuring the cross-sectional psoas muscle area (PA) at L3 and total bilateral psoas muscle volume (PV). Patients with a lower PV or PA value than the median were assigned to the sarcopenia group while others were assigned to the non-sarcopenia group. Clinical outcomes were then compared between groups. RESULTS: The sarcopenia group included 22 patients. The rate of overall postoperative complications did not differ between groups. Five-year relapse-free survival (RFS) was significantly lower in the sarcopenia group when sarcopenia was assessed by PV after NACRT (44.0% vs. 82.6%, P = 0.00494). In contrast, RFS did not differ between groups when sarcopenia was assessed by PA. Multivariable analysis identified PV after NACRT as the most significant risk factor for RFS (hazard ratio 4.00; 95% CI 1.27-12.66, P = 0.018). CONCLUSION: Sarcopenia assessed by total PV after NACRT may be an accurate and reliable predictor of poor oncological outcomes in rectal cancer patients.Oct. 2021, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(4) (4), 850 - 856, English, International magazineScientific journal
- BACKGROUND: Robotic gastrectomy (RG) has increased since being covered by universal health insurance in 2018. However, to ensure patient safety the operating surgeon and facility must meet specific requirements. We aimed to determine whether RG has been safely implemented under the requirements for universal health insurance in Japan. METHODS: Data of consecutive patients with primary gastric cancer who underwent minimally invasive total or distal gastrectomy-performed by a surgeon certified by the Japan Society for Endoscopic Surgery (JSES) endoscopic surgical skill qualification system (ESSQS) between October 2018 and December 2019-were extracted from the gastrointestinal surgery section of the National Clinical Database (NCD). The primary outcome was morbidity over Clavien-Dindo classification grade IIIa. Patient demographics and hospital volume were matched between RG and laparoscopic gastrectomy (LG) using propensity score-matched analysis (PSM), and the short-term outcomes of RG and LG were compared. RESULTS: After PSM, 2671 patients who underwent RG and 2671 who underwent LG were retrieved (from a total of 9881), and the standardized difference of all the confounding factors reduced to 0.07 or less. Morbidity rates did not differ between the RG and LG patients (RG, 4.9% vs. LG, 3.9%; p = 0.084). No difference was observed in 30-day mortality (RG, 0.2% vs. LG, 0.1%; p = 0.754). The reoperation rate was greater following RG (RG, 2.2% vs. LG, 1.2%; p = 0.004); however, the duration of postoperative hospitalization was shorter (RG, 10 [8-13] days vs. LG, 11 [9-14] days; p < 0.001). CONCLUSIONS: Insurance-covered RG has been safely implemented nationwide.Oct. 2021, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 25(2) (2), 438 - 449, English, Domestic magazineScientific journal
- 金原出版(株), Oct. 2021, 手術, 75(11) (11), 1673 - 1677, Japanese
- Oct. 2021, J Cancer Res Ther, 17(6) (6), 1358 - 1369Microsatellite instability-high colorectal cancer patient-derived xenograft models for cancer immunity research[Refereed]
- Oct. 2021, Annals of surgical oncology, 28(11) (11), 6339 - 6340, English, International magazineScientific journal
- INTRODUCTION: The closure of the appendiceal stump is a crucial part of a laparoscopic appendectomy, and an endoloop or endostapler is generally used. The endoloop can be more cost effective than the endostapler. However, reports have shown that the endoloop has a higher postoperative abdominal abscess rate than the endostapler in complicated appendicitis. At our institution, we perform a purse-string suture after ligating by endoloop to reduce postoperative abdominal abscess risk. This study aimed to clarify whether this method could reduce the incidence of postoperative abdominal abscess compared with the endostapler. METHODS: Patients with acute appendicitis were classified into the purse-string suture group (n = 149) and the endostapler group (n = 82). Postoperative outcomes were compared after propensity score matching (n = 47). RESULTS: No significant difference was found between the two groups in terms of the patient characteristics and postoperative complications, including abdominal abscess. However, the purse-string suture group had more drain placement and a shorter hospital stay than the endostapler group (P = .04 and P = .02, respectively). In patients with complicated appendicitis, there was less drain placement and a shorter hospital stay in the purse-string suture group than in the endostapler group (P < .01 and P < .01, respectively). This might have reflected the difficulty of the operation. All postoperative abdominal abscesses occurred in complicated appendicitis cases. CONCLUSIONS: Endoloop with additional purse-string suture had a lower incidence of abscess than previous reports of using endoloop alone. Moreover, the postoperative abdominal abscess rate is similar between the two closure methods.Oct. 2021, Asian journal of endoscopic surgery, 14(4) (4), 775 - 781, English, Domestic magazineScientific journal
- BACKGROUND: Retrosternal reconstruction is associated with a lower risk of mediastinitis, gastro-tracheal fistula, and hiatal hernia. Historically, traumatic manual creation of the retrosternal tunnel has been performed using one's fist. We report a novel and atraumatic laparoscopic procedure to create the retrosternal route. METHODS: We have laparoscopically created the retrosternal route in 25 thoracoscopic, mediastinoscopic, or robot-assisted minimally invasive esophagectomies since August 2019. Specifically, a peritoneal incision is started at the dorsal side of the xiphoid process. Through a 12-mm port inserted slightly to the right of and superior to the umbilical camera port, we dissect loose connective tissues from the caudal to the cranial side using behind the sternum and inside the internal thoracic vessels as landmarks. The time required to create the route was calculated. Then, the cumulative sum (CUSUM) method and the simple moving average of five cases were used to evaluate the learning curve of this novel procedure. Operative outcomes were analyzed according to the learning curve results and also compared with 25 cases of postmediastinal reconstruction counterparts. RESULTS: Twenty-five patients were divided into the early group (six patients) and late group (19 patients) based on the peak of the CUSUM chart. The time required for route creation was 28.5 min (median) in the early and 15 min in the late group, indicating a significant difference (P = 0.038). The overall incidence of pleural injury was 20% (5 of 25 patients), with no significant difference between the groups. There was no significant difference in the incidence of perioperative complications. Also, there were no significant differences in perioperative complications or gastric conduit functions 1 year after surgery between the retrosternal and the postmediastinal reconstruction. CONCLUSION: Laparoscopic creation of a retrosternal route for gastric conduit reconstruction is safe and feasible and has a short learning curve.Sep. 2021, Surgical endoscopy, 36(4) (4), 2680 - 2687, English, International magazineScientific journal
- BACKGROUND/PURPOSE: The day of the week can impact medical treatment outcomes; however, few large-scale, disease-specific studies have focused on the association between the day of the week and mortality in patients after pancreatoduodenectomy for pancreatic head cancer. METHODS: Data were obtained from the National Clinical Database. Twenty-two clinical variables were adopted for hierarchal logistic regression modeling to determine adjusted odds ratios (ORs) for surgical mortality after elective pancreatoduodenectomy. RESULTS: The 30-day mortality and surgical mortality rates were 1.0% and 1.7%, respectively (n = 29 720). Surgeries were performed the least on Fridays (13.4%) compared with other weekdays. Crude rates of severe postoperative complications (mean, 14.1%; range, 13.5%-14.8%) and pancreatic fistulas (mean, 10.0%; range, 9.6%-10.3%) remained stable throughout the week. Unadjusted/adjusted ORs did not significantly differ between Friday and Monday (0.868, 95% CI: 0.636-1.173, P = .365, and 0.928, 95% CI: 0.668-1.287, P = .653, respectively), and results were similar for the remaining weekdays. Nineteen independent factors were associated with surgical mortality. CONCLUSIONS: The rate of perioperative mortality for elective pancreatoduodenectomy is low in Japan, with no evidence of disparities in surgical mortality rates between weekdays.Sep. 2021, Journal of hepato-biliary-pancreatic sciences, 29(7) (7), 778 - 784, English, Domestic magazineScientific journal
- BACKGROUND: Robot-assisted laparoscopic surgery has several advantages over conventional laparoscopy. However, population-based comparative studies for low anterior resection are limited. This article aimed to compare peri-operative results of robot-assisted low anterior resection (RALAR) and laparoscopy. METHODS: This retrospective cohort study used data from patients treated with RALAR or conventional laparoscopic low anterior resection (CLLAR) between October 2018 and December 2019, as recorded in the Japanese National Clinical Database, a data set registering clinical information, perioperative outcomes, and mortality. Of note, the registry does not include information on the tumour location (centimetres from the anal verge) and diverting stoma creation. Perioperative outcomes, including rate of conversion to open surgery, were compared between RALAR and CLLAR groups. Confounding factors were adjusted for using propensity score matching. RESULTS: Of 21 415 patients treated during the study interval, 20 220 were reviewed. Two homogeneous groups of 2843 patients were created by propensity score matching. The conversion rate to open surgery was significantly lower in the RALAR group than in the CLLAR group (0.7 versus 2.0 per cent; P < 0.001). The RALAR group had a longer operating time (median: 352 versus 283 min; P < 0.001), less intraoperative blood loss (15 versus 20 ml; P < 0.001), a lower in-hospital mortality rate (0.1 versus 0.5 per cent; P = 0.007), and a shorter postoperative hospital stay (median: 13 versus 14 days; P < 0.001) compared with the CLLAR group. The CLLAR group had a lower rate of readmission within 30 days (2.4 versus 3.3 per cent; P = 0.045). CONCLUSION: These data highlight the reduced conversion rate, in-hospital mortality rate, intraoperative blood loss, and length of postoperative hospital stay for rectal cancer surgery in patients treated using robot-assisted laparoscopic surgery compared with laparoscopic low anterior resection.Sep. 2021, BJS open, 5(5) (5), English, International magazineScientific journal
- BACKGROUND: Esophagectomy followed by gastric conduit reconstruction is a standard surgical procedure for esophageal cancer. However, there is no evidence of the superiority or inferiority of the posterior mediastinal (PM) versus the retrosternal (RS) reconstruction route with regard to short-term outcomes after esophagectomy. We aimed to elucidate whether the reconstruction route can affect the short-term outcomes after esophagectomy followed by gastric conduit reconstruction. METHODS: We reviewed the clinical data of patients who underwent esophagectomy between 2016 and 2018 from the Japanese National Clinical Database. This study included 9786 patients who underwent gastric conduit reconstruction through the PM or RS route with cervical anastomosis. RESULTS: Of the 9786 patients analyzed, 3478 and 6308 underwent gastric conduit reconstruction thorough the PM and RS routes, respectively. The incidence of anastomotic leak and surgical site infection (SSI) was significantly lower in the PM group than in the RS group (11.7% vs 13.8%, P = .005 and 8.4% vs 14.9%, P < .001, respectively), while the incidence of pneumonia was higher in the PM group (13.7% vs 12.2%, P = .040). Generalized estimating equation logistic regression analysis revealed a higher risk of anastomotic leak and SSI (odds ratio [OR], 1.32; 95% confidence interval [CI], 1.15-1.51; P < .001 and OR, 2.06; 95% CI, 1.78-2.38; P < .001, respectively) and a lower risk of pneumonia (OR, 0.86; 95% CI, 0.75-0.98; P = .028) in the RS group than in the PM group. CONCLUSION: The findings of this study will help surgeons to design the reconstruction route following esophagectomy.Wiley, Sep. 2021, Annals of Gastroenterological Surgery, 6(1) (1), 46 - 53, English, Domestic magazineScientific journal
- Sep. 2021, Surgical endoscopy, 36(5) (5), 3676 - 3676, English, International magazine
- 金原出版(株), Sep. 2021, 手術, 75(10) (10), 1519 - 1524, Japanese
- (株)自然科学社, Sep. 2021, 医学と薬学, 78(10) (10), 1167 - 1173, Japanese
- Aim: Preoperative inflammation-based Glasgow prognostic score (GPS) is a useful tool for predicting long-term prognosis in cancer patients. However, its association with postoperative short-term outcomes remains unknown. The aim of this study is to investigate the association between GPS and postoperative morbidity and mortality among patients undergoing surgery for various gastrointestinal malignancies. Methods: Using the Japanese National Clinical Database, we analyzed the records of 312 357 patients with gastrointestinal malignancy who underwent six typical elective surgeries, including esophagectomy, distal gastrectomy, total gastrectomy, right hemicolectomy, low anterior resection, and pancreaticoduodenectomy, between January 2015 and December 2018. We assigned GPS of 0, 1, or 2 to patients with no, one, or both decreased albumin and elevated C-reactive protein levels, respectively. We investigated the relationship of GPS with operative morbidity and mortality for each procedure with adjustments for patients' demographics, preoperative status, comorbidities, and cancer stages. Results: Crude operative morbidity was significantly higher for GPS 1 and 2 than GPS 0 patients in all procedures except pancreaticoduodenectomy. The postoperative length of hospital stay was significantly longer for GPS 1 and 2 patients in all procedures (P < .001). Operative mortality was also higher for GPS 1 and 2 patients in all procedures. The associations remained significant after adjustments for potential confounders of age, sex, physical status, tumor classification, use of preoperative therapy, and comorbidities. Conclusion: This nationwide study provides solid evidence on the strong association between GPS and postoperative outcomes.Sep. 2021, Annals of gastroenterological surgery, 5(5) (5), 659 - 668, English, Domestic magazineScientific journal
- Sep. 2021, Annals of surgical oncology, 28(9) (9), 4928 - 4928, English, International magazineScientific journal
- PURPOSE: We conducted a prospective clinical control study to identify the best imaging technology among three-dimensional (3-D) high-definition (HD) stereovision and two-dimensional (2-D) ultra-high-resolution (4 K) technology and confirm their effects on surgical outcomes of laparoscopic gastrectomy for gastric cancer. METHODS: From April 2018 to August 2019, 50 patients were randomly classified into two groups based on the imaging technology (3-D/HD group = 25, 2-D/4 K = 25). After excluding eight patients based on laparoscopic findings, 42 patients were analyzed (3-D/HD group = 21, 2-D/4 K = 21). The primary endpoint was the operative time; the secondary endpoints were blood loss, postoperative infectious complications, and postoperative hospital stay. RESULTS: The patients' backgrounds were similar (sex, age, body mass index [BMI], stage, procedure, and extent of lymph node dissection). There were no significant differences in operative time (252 vs. 238 min, P = 0.70), total blood loss, postoperative infectious complications, and postoperative hospital stay between the two groups. However, video analysis of surgeries revealed a significantly shortened median operative time (18 vs. 25 min, P = 0.04) in the suturing step with 3-D/HD; the median number of camera cleaning procedures during suprapancreatic lymph node dissection was significantly lower with 2-D/4 K than with 3-D/HD (n = 4.4 vs. 2.8, P = 0.02). CONCLUSION: 3-D/HD and 2-D/4 K laparoscopic radical gastrectomies provide similar surgical outcomes. However, the 3-D monitor reduces suturing time during reconstruction, while the 4 K monitor reduces the number of camera cleaning procedures during lymphadenectomy. TRIAL REGISTRATION: Registered in the University Hospital Medical Information Network Clinical Trials Registry (identification number 000029227).Aug. 2021, Langenbeck's archives of surgery, 407(1) (1), 105 - 112, English, International magazineScientific journal
- PURPOSE: The second planned interim analysis (median follow-up 12.5 months) in a phase III trial of postoperative adjuvant chemotherapy for stage III gastric cancer revealed significant improvement in relapse-free survival (RFS) for S-1 plus docetaxel over S-1 alone. Although enrollment was terminated on the recommendation of the independent data and safety monitoring committee, we continued follow-up and herein report on 3-year RFS, the primary endpoint. PATIENTS AND METHODS: Patients with histologically confirmed stage III gastric cancer who underwent gastrectomy with D2 lymphadenectomy were randomly assigned to receive adjuvant chemotherapy with either S-1 plus docetaxel or S-1 alone. In the S-1 plus docetaxel group, S-1 was given orally for 2 weeks followed by 1 week of rest for seven courses, and docetaxel was given intravenously on day 1 of the second to seventh courses. The combination therapy was followed by S-1 monotherapy for up to 1 year. RESULTS: The 3-year RFS rate of the S-1 plus docetaxel group was 67.7%. This was significantly superior to that of 57.4% in the S-1 group (hazard ratio [HR] 0.715, 95% CI 0.587-0.871, P = 0.0008). This translated into a significant benefit in the 3-year overall survival (OS) rate in the S-1 plus docetaxel group (77.7% versus 71.2%, HR 0.742, 95% CI 0.596-0.925, P = 0.0076). CONCLUSION: On 3-year follow-up data, postoperative adjuvant therapy with S-1 plus docetaxel was confirmed to improve both RFS and OS and can be recommended as a standard of care for patients with stage III gastric cancer treated by D2 dissection.Aug. 2021, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 25(1) (1), 188 - 196, English, Domestic magazineScientific journal
- PURPOSE: Laparoscopic local resection for gastrointestinal stromal tumors (GISTs) near the esophagogastric junction (EGJ) increases the risk of injuring the EGJ. We investigated the safety of laparoscopic local resection for GISTs near the EGJ according to the distance from the EGJ to the tumor edge. METHODS: We retrospectively evaluated 40 patients who had undergone laparoscopic local resection for GISTs near the EGJ between January 2009 and December 2019. After excluding 1 patient who had undergone right colectomy at the same time, 39 patients were classified according to distance of the GIST from the EGJ in the Near group (0-2.0 cm; n = 16) and the Far group (2.1-5.0 cm; n = 23). RESULTS: We found no marked differences in the operation time, blood loss, length of postoperative hospital stay, or postoperative complication rate in the two groups. Anastomotic leakage occurred with a tumor located on the EGJ. Three tumors recurred in the Near group, and all of them were located on the EGJ. CONCLUSION: Except for GISTs located on the EGJ, laparoscopic local resection for GISTs near the EGJ can be performed safely with few postoperative complications and a low risk of recurrence.Jul. 2021, Surgery today, 52(3) (3), 395 - 400, English, Domestic magazineScientific journal
- 金原出版(株), Jul. 2021, 手術, 75(8) (8), 1259 - 1267, Japanese
- Aim: The outcomes of gastrectomy for gastric cancer in patients at each severity of chronic kidney disease (CKD) remain unknown. Methods: We retrospectively analyzed the outcomes of 560 patients who underwent distal or total gastrectomy for gastric cancer between 2009 and 2018. We classified the patients into four groups based on estimated glomerular filtration rate: stage 1/2 (normal to mild, n = 375), stage 3a (mild to moderate, n = 122), stage 3b (moderate to severe, n = 43), and stage 4/5 (severe to end-stage, n = 20) CKD. The relationship between CKD stage and the incidence of postoperative morbidity was analyzed. Results: CKD was a predictor of overall morbidity independent of age, gender, American Society of Anesthesiologists Performance Status, pulmonary comorbidity, extent of lymphadenectomy, and operation time in a multivariate analysis. The incidences of overall and severe morbidity were significantly increased with CKD progression (both P < .001). Compared to stage 1/2 CKD, the odds of overall morbidity were significantly elevated in stage 3a (odds ratio [OR] 1.87, P = .007), stage 3b (OR 3.86, P < .001), and stage 4/5 (OR 8.60, P < .001). The risk of procedure-related morbidity was strikingly increased in stage 3b (OR 2.93, P = .004). The risk of procedure-unrelated morbidity elevated markedly in stage 3a (OR 2.77, P = .001). A significant graded association between CKD progression and overall morbidity was also revealed in elderly patients (P = .001). Conclusions: The severity of CKD predicts the likelihood and type of morbidity after gastrectomy and can guide surgical decision-making for patients with gastric cancer.Jul. 2021, Annals of gastroenterological surgery, 5(4) (4), 519 - 527, English, Domestic magazineScientific journal
- (株)へるす出版, Jun. 2021, 消化器外科, 44(7) (7), 1193 - 1202, Japanese【消化器外科とAI】AIを用いた腹腔鏡下胃癌手術における手術器具自動認識システムの開発と利用
- 金原出版(株), Jun. 2021, 手術, 75(7) (7), 1153 - 1159, Japanese
- (株)へるす出版, May 2021, 消化器外科, 44(6) (6), 705 - 708, Japanese【消化器癌;診断と治療のすべて】消化器癌の診断・病期分類・治療・成績 胃癌 集学的治療
- (株)メディカ出版, Apr. 2021, 消化器ナーシング, (2021春季増刊) (2021春季増刊), 154 - 155, Japanese
- (株)メディカ出版, Apr. 2021, 消化器ナーシング, (2021春季増刊) (2021春季増刊), 156 - 157, Japanese
- (株)メディカ出版, Apr. 2021, 消化器ナーシング, (2021春季増刊) (2021春季増刊), 158 - 159, Japanese
- (株)メディカ出版, Apr. 2021, 消化器ナーシング, (2021春季増刊) (2021春季増刊), 160 - 161, Japanese
- BACKGROUND: Given the worldwide popularization of conventional minimally invasive esophagectomy (C-MIE), robot-assisted MIE (RAMIE) can be expected to provide a finer procedure. However, controversy remains regarding whether RAMIE is superior to C-MIE in preventing recurrent laryngeal nerve (RLN) palsy. Considering the shallow learning curve for RAMIE, a novel procedure for lymphadenectomy along the RLN during RAMIE is needed. METHODS: Based on a logical and simple understanding of the left upper mediastinum anatomy, the authors developed a novel "modified bascule method" for RAMIE that could simplify lymphadenectomy along the left RLN and prevent it from being touched and stretched. Between 2018 and 2020, 46 patients with esophageal carcinoma underwent RAMIE using this method at Kobe University. RESULTS: The modified bascule method was used to perform RAMIE for 29 men and 17 women with a median age of 67 years (range, 49-82 years). The median thoracoscopic procedure time was 438 min (range, 344-625 min), and the median console time was 351 min (range 273-518 min). The study harvested a median of 24 (range, 8-34) lymph nodes from the thoracic portion and 4 (range, 0-10) lymph nodes from along the left RLN. The mortality rate was 0%. Postoperative left RLN palsy classified as Clavien-Dindo (C-D) grade 1 or higher was observed for 9 patients (19%), whereas grade 2 or higher was not seen (0%). Pneumonia and anastomotic leakage rates higher than C-D grade 2 were respectively 13% and 19%. CONCLUSIONS: The novel modified bascule method for RAMIE can promote feasible lymphadenectomy along the left RLN even when performed during the learning period.Mar. 2021, Annals of surgical oncology, English, International magazineScientific journal
- BACKGROUND: This study aimed to analyse the perioperative results from a national dataset of rectal cancer resections in elderly patients. METHODS: The clinical records of patients undergoing rectal cancer surgery between 2012 and 2014 were retrieved from the Japanese National Clinical Database and analysed retrospectively. Patients were categorized according to age and those 80 years or older were defined as elderly. Subgroups were also defined according to the surgical approach (laparoscopy versus open surgery). The short-term outcomes, including mortality, anastomotic leak, surgical site infections and medical complications were compared between subgroups. RESULTS: Of 56 175 patients undergoing rectal cancer surgery, some 6717 patients were elderly and laparoscopy was performed in 46.8 per cent of the sample. When comparing laparoscopy and open surgery in elderly patients, the operative mortality rate (1.5 versus 2.8 per cent; P < 0.001), the incidence of anastomotic leakage (5.2 versus 6.5 per cent; P = 0.026), surgical site infections (6.0 versus 8.0 per cent; P = 0.001), pneumonia (1.4 versus 2.5 per cent; P = 0.001), renal failure (0.7 versus 1.3 per cent; P = 0.016) and cardiac events (0.3 versus 0.8 per cent; P = 0.008) were lower for laparoscopy than for open surgery. The overall complication rate in elderly patients (19.5 per cent) was comparable to that in the younger group (P = 0.07). However, incidence of systemic complications was significantly higher in elderly than in younger patients (all P < 0.001). CONCLUSION: Laparoscopy was safe and feasible in elderly patients compared with open surgery. However, the rates of systemic complications were significantly higher than in younger patients.Mar. 2021, BJS open, 5(2) (2), English, International magazineScientific journal
- PURPOSE: This study compared the quality of healthcare before and after implementation of a policy restructuring the healthcare delivery system and estimated the impact of centralization. METHODS: We used the National Clinical Database to study patients undergoing esophagectomies from 2011 to 2016. We compared the effect of centralization based on the patient background, surgical mortality, and year of surgery. Difference-in-difference methods based on the generalized estimating equation logistic regression model were used for before-and-after comparisons after adjusting for patient-level expected surgical mortality. RESULTS: In total, 34,640 cases were identified. More cases with risk factors were noted in ultra-low-volume hospitals, where 38.4% of cases in underpopulated areas were treated, than in higher volume facilities, and the operative mortality, readmission within 30 days and length of stay were worse among patients treated in these hospitals. In centralized prefectures, the number of cases per hospital increased over time (7.2 in 2011 to 9.5 in 2016) while the crude operative mortality tended to decrease (3.4% in 2011 to 1.8% in 2016). The difference-in-difference estimator was 0.856 (95% confidence interval: 0.639-1.147, p = 0.298). CONCLUSION: The centralization of ultra-low-volume hospitals did not lead to a deterioration in the quality of care but rather an improving trend.Mar. 2021, Surgery today, English, Domestic magazineScientific journal
- (一社)日本内視鏡外科学会, Mar. 2021, 日本内視鏡外科学会雑誌, 25(7) (7), SP5 - 2, JapaneseNCDデータを用いた、本邦での腹腔鏡下直腸手術の年齢別短期成績の検討
- (一社)日本内視鏡外科学会, Mar. 2021, 日本内視鏡外科学会雑誌, 25(7) (7), SP5 - 4, Englishロボット支援消化管手術の普及と安全性に関するNational Clinical Databaseを用いた解析
- BACKGROUND/AIM: The safety of neoadjuvant chemoradiotherapy (NACRT) combined with total mesorectal excision (TME) and selective lateral pelvic lymph node dissection (LLND) is unclear in elderly patients with locally advanced rectal cancer (LARC). PATIENTS AND METHODS: Forty-two patients with LARC underwent TME and selective LLND following NACRT at Kobe University Hospital. The clinical outcomes were retrospectively compared between the elderly (aged ≥70 years, n=13) and non-elderly patients (aged <70, n=29). RESULTS: Twelve of the thirteen elderly patients could complete NACRT. Although the overall rate of postoperative complications did not differ between the groups, abdominal wound infection and deep vein thrombosis developed more frequently in the elderly group. The length of the postoperative hospital stay was similar. Three-year overall survival and 3-year relapse-free survival rates were similar between the groups. CONCLUSION: Selective LLND after NACRT is safe for elderly patients with LARC.Mar. 2021, Anticancer research, 41(3) (3), 1677 - 1682, English, International magazineScientific journal
- Cancer-associated fibroblasts (CAFs) contribute to the progression of various cancers. Previously, we reported the significance of CAFs in esophageal squamous cell carcinoma (ESCC); however, the functions of CAFs in the ESCC microenvironment remain unknown. To investigate CAFs' function, we established an indirect coculture assay between human bone marrow-derived mesenchymal stem cells (MSCs) and ESCC cells. Cocultured MSCs expressed more fibroblast activation protein, one of the markers of CAFs, compared with monocultured MSCs. Therefore, we defined cocultured MSCs as CAF-like cells. To identify molecules associated with the ESCC progression in CAFs, we conducted a cDNA microarray analysis on monocultured MSCs and CAF-like cells to compare their gene expression profiles. We found that SERPINE1, which encodes plasminogen activator inhibitor-1 (PAI-1), was more abundant in CAF-like cells than in monocultured MSCs, and the PAI-1 derived from CAF-like cells induced the abilities of migration and invasion in both ESCC cells and macrophages by the Akt and Erk1/2 signaling pathways via the low-density lipoprotein receptor-related protein 1 (LRP1), which is a PAI-1 receptor. Based on immunohistochemistry assays of ESCC tissues, higher expression levels of PAI-1 and LRP1 were correlated with poor prognosis in ESCC patients. These results suggest that the PAI-1/LRP1 axis contributes to the progression of ESCC, making it a potential target for ESCC therapy.Mar. 2021, Laboratory investigation; a journal of technical methods and pathology, 101(3) (3), 353 - 368, English, International magazineScientific journal
- BACKGROUND: Despite interest in surgeon and hospital volume effects on total gastrectomy (TG), clinical significance has not been confirmed in a large-scale population. This study aimed at clarifying the association of surgeon and hospital volume on postoperative mortality after TG for gastric cancer among Japanese patients in National Clinical Database (NCD). METHODS: Between 2011 and 2015, we retrospectively extracted data on TG for gastric cancer from the NCD. The primary outcome was operative mortality. We divided surgeon volume as the number of TGs performed by a patient's surgeon in the previous year: S1 (0-2 cases), S2 (3-9), S3 (10-25), S4 (26-79) and hospital volume by the number of TGs performed in the previous year: H1 (0-11 cases), H2 (12-26), H3 (27-146). We calculated the 95% confidence interval (CI) for the mortality rate based on odds ratios (OR) estimated from a hierarchical logistic regression model. RESULTS: We analyzed 71,307 patients at 2051 institutions. Low-volume surgeons and hospitals had significantly older and poorer-risk patients with various comorbidities. The operative mortality rate decreased with surgeon volume, 2.5% in S1 and 0.6% in S4. The operative mortality was 3.1% in H1, 1.7% in H2, and 1.2% in H3. After risk adjustment for surgeon, hospital volume and patient characteristics, hospital volume was significantly associated with operative morality (H3: OR = 0.53, 95% CI 0.43-0.63). CONCLUSIONS: We demonstrate hospital volume has an impact on postoperative mortality after TG in a nationwide population study. These findings suggest centralization may improve outcomes after TG.Mar. 2021, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 24(2) (2), 526 - 534, English, Domestic magazineScientific journal
- BACKGROUND: Chemoradiotherapy is an alternative to surgery for esophageal cancer, with a putatively equivalent outcome. However, disease recurrence after a complete response is common and if follow-up surveillance detects recurrence, salvage treatments for potentially curable disease must follow. METHODS: We conducted a nation-wide questionnaire survey of institutions in Japan certified by the Japanese Esophageal Society to investigate outcomes of primary thoracic esophageal cancer patients initially treated by chemoradiotherapy with complete response diagnoses. The primary endpoint was overall survival, the secondary endpoint disease recurrence. Outcomes of patients who had undergone salvage treatments were also investigated. Cases were excluded from analysis if endoscopic study, endoscopic biopsy, or computed tomography data were lacking. RESULTS: At 41 institutes 544 case records were collected; valid data on 392 patients were obtained; 5-year survival was 74.8%, 5-year disease-free survival, 66.8%. Clinical staging before treatment significantly affected both overall and disease-free survival rates, but differences between adjoining stages were unexpectedly small. The primary relapse site was classified as primary site (n = 58), regional lymph nodes (n = 36), or distant disease (n = 34). Salvage treatments with curative intent (surgery, endoscopic treatments, and additional radiation) were performed on 38, 23, and 4 cases; 5-year survival after esophagectomy (n = 22), endoscopic treatment (n = 23), and lymphadenectomy (n = 9) was 47.4%, 70.9%, and 33.3%, respectively. CONCLUSIONS: A quarter of patients developed recurrent disease, mostly locoregional, after complete response. Complete response patients with originally advanced stage disease had fair clinical outcomes; salvage treatments after locoregional recurrence achieved modest long-term survival.Feb. 2021, Esophagus : official journal of the Japan Esophageal Society, English, Domestic magazineScientific journal
- BACKGROUND: Esophageal neuroendocrine carcinoma (ENEC) is an extremely rare type of tumor characterized by a high malignant potential, rapid growth, and poor prognosis. Because the standard therapy for ENEC has been poorly defined, we herein aimed to attain a clear view of the current state of treatment for ENEC by performing a large-scale, multicenter study. METHODS: We conducted a questionnaire-based, retrospective clinical review of 142 patients with ENEC treated at 37 hospitals accredited by the Japan Esophageal Society from January 2010 to December 2015. RESULTS: The most frequent main treatment performed was an operation, followed by chemoradiotherapy, chemotherapy, and endoscopic submucosal dissection. Among the 67 patients who underwent surgery, 28 (19.7%) were not accurately diagnosed with NEC or a combined NEC tumor by pretreatment biopsy. The 5-year overall survival rate of all patients was 33.2%. Among patients with Stages III and IV disease, the prognosis was significantly better in patients who underwent chemoradiotherapy than in patients who underwent other treatments. Among patients with Stages I and II disease, however, there was no difference in survival rates between those who underwent surgery and chemoradiotherapy. CONCLUSIONS: This nationwide survey is a valuable report of the current status of treatment of ENEC in a limited number of cases experienced at each participating institution. The survival benefit obtained from surgery was considered to be limited, especially for Stages III and IV ENEC. Accurate pretreatment histological diagnosis is essential to determine the most appropriate treatment strategy for patients with ENEC.Feb. 2021, Journal of gastroenterology, English, Domestic magazineScientific journal
- BACKGROUND/AIM: Biomarkers for immune-related adverse events (irAEs) induced by immune checkpoint inhibitors (ICIs) are required. We encountered a patient whose skin irAE fluctuated in parallel with serum soluble interleukin-2 receptor (sIL-2R). PATIENTS AND METHODS: We examined 15 patients with cancer who received ICIs. Serum sIL-2R levels before and during ICI treatment were measured. The sIL-2R levels of preserved serum samples from another five patients who developed grade 3 irAEs were measured. RESULTS: Twelve patients showed no significant changes in sIL-2R levels during ICI treatment. Baseline serum sIL-2R levels in three patients increased beyond the normal range before the second cycle. These three patients had grade ≥2 irAEs at the second cycle treatment visit, supporting our hypothesis. Furthermore, at diagnosis of irAEs, the sIL-2R levels of all preserved samples from patients with grade 3 irAEs were significantly elevated. CONCLUSION: Serum sIL-2R is a promising biomarker for the diagnosis of irAEs.Feb. 2021, Anticancer research, 41(2) (2), 1021 - 1026, English, International magazineScientific journal
- BACKGROUND: Although transanal total mesorectal excision (ta-TME) is adopted for rectal cancer surgery by an increasing number of surgeons, it is still technically challenging. We have employed a lateral-first approach for ta-TME to overcome technical difficulties. However, its outcomes and advantage over conventional laparoscopic TME remain unclear. METHODS: Thirty-five consecutive patients who underwent ta-TME using a lateral-first approach (the ta-TME group) and 53 consecutive patients who underwent conventional laparoscopic TME (the lap-TME group) for low rectal cancer were included. Propensity score matching (PSM) was used to create balanced cohorts of ta-TME (n = 28) and lap-TME (n = 28). Their clinical outcomes were compared after PSM. RESULTS: The operative time and intraoperative blood loss were significantly lower in the ta-TME group than in the lap-TME group (P = 0.042 and P < 0.001, respectively). Postoperative complications ≥ Clavien-Dindo grade II were significantly less and postoperative hospital stay was significantly shorter in the ta-TME group (35.7% vs. 78.6%, P = 0.003, and 18 days vs. 32 days, P < 0.001, respectively). The distal margin was significantly larger in the ta-TME when excluding the abdominoperineal resection cases (20 mm vs. 10 mm, P = 0.032). The positive radial margin was observed in 2 of 28 patients (7.1%) in the ta-TME group. CONCLUSIONS: Ta-TME using a lateral-first approach is feasible and may offer several advantages over lap-TME in terms of short-term outcomes. It might be an alternative safe approach for ta-TME. To confirm the oncological superiority of this surgery, further study in a larger population and for a longer follow-up period is warranted.Feb. 2021, Surgical endoscopy, 35(2) (2), 971 - 978, English, International magazineScientific journal
- The National Clinical Database (NCD) of Japan was established in 2010 with the board certification system. A joint committee of 16 gastroenterological surgery database-affiliated organizations has been nurturing this nationwide database and utilizing its data for various analyses. Stepwise board certification systems have been validated by the NCD and are used to improve the surgical outcomes of patients. The use of risk calculators based on risk models can be particularly helpful for establishing appropriate and less invasive surgical treatments for individual patients. Data obtained from the NCD reflect current developments in the surgical approaches used in hospitals, which have progressed from open surgery to endoscopic and robot-assisted procedures. An investigation of the data acquired by the NCD could answer some relevant clinical questions and lead to better surgical management of patients. Furthermore, excellent surgical outcomes can be achieved through international comparisons of the national databases worldwide. This review examines what we have learned from the NCD of gastroenterological surgery and discusses what future developments we can expect.Feb. 2021, Surgery today, 51(2) (2), 187 - 193, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: During the past decade, minimally invasive esophagectomy (MIE) for esophageal cancer has been adopted worldwide with expectations of lower invasiveness. However, the rate of postoperative pneumonia, which is an independent risk factor for oncological prognosis in esophageal cancer, remains high. The aim of this retrospective follow-up study is to clarify whether there is a strong correlation between recurrent laryngeal nerve (RLN) palsy and postoperative pneumonia in MIE. METHODS: This retrospective follow-up study included 209 patients with esophageal cancer who underwent thoracoscopic esophagectomy in the prone position (TEP) at Kobe University between 2011 and 2018. Inclusion criteria included age 18-85 years; cT1-3, cN0-3 disease; upper mediastinal lymphadenectomy; and ability to undergo simultaneous esophagectomy and reconstruction of the gastric conduit or pedicled jejunum. Univariate and multivariate logistic regression were conducted to identify independent risk factors for pneumonia. RESULTS: Among 209 TEPs, pneumonia of Clavien-Dindo classification grade > II occurred in 44 patients (21%). In the pneumonia positive and negative groups, there were significant differences in age (67.9 ± 7.5 vs. 64.9 ± 8.6 years), 3-field lymph node dissection [27 (61%) vs. 67 (41%)], transfusion [20 (45%) vs. 41 (25%)], left RLN palsy [19 (43%) vs. 18 (11%)], and any RLN palsy [20 (45%) vs. 18 (11%)]. In multivariate analysis, any RLN palsy was associated with a higher incidence of pneumonia [odds ratio (OR), 6.210; 95% confidence interval (CI), 2.728-14.480; P < 0.0001]. In addition, age was associated with a higher incidence of pneumonia (OR, 1.049; 95% CI, 1.001-1.103; P = 0.046). Changes in the rate of any RLN palsy over time were quite similar to changes in the incidence of pneumonia. CONCLUSION: There is a strong correlation between RLN palsy and pneumonia in MIE for esophageal cancer. Prevention of RLN palsy may reduce the incidence of pneumonia, leading to better oncological prognosis.Feb. 2021, Surgical endoscopy, 35(2) (2), 837 - 844, English, International magazine[Refereed]Scientific journal
- The gene mutation profiles of gastric neuroendocrine neoplasms are incompletely understood. The purpose of this study was to characterize the molecular pathology of poorly differentiated neuroendocrine carcinoma (NEC) and mixed neuroendocrine‒non-neuroendocrine neoplasm (MiNEN) of the stomach. Surgical cases of gastric NEC (n = 7) and MiNEN (n = 6) were examined by clinical review, immunohistochemistry, microsatellite instability (MSI) analysis and whole-exome sequencing. NEC cases consisted of small- (n = 2) and large-cell types (n = 4). All cases of MiNEN were histologically composed of large-cell type NEC and tubular adenocarcinoma. Whole-exome sequencing analysis detected recurrent mutations in TP53 in 8 cases (62%), and they were more frequently observed in MiNEN than in NEC (100% vs. 29%). Frameshift mutations of APC were observed in two cases of MiNEN. One case of large-cell type NEC had a frameshift mutation with loss of heterozygosity in RB1. The other mutated genes (e.g., ARID1 and KRAS) were detected in a single case each. A high level of MSI was confirmed in one case of MiNEN, which harbored mutations in two well-differentiated neuroendocrine tumor (NET)-related genes (MEN1 and ATRX1). In cases of MiNEN, two histological components shared mutations in TP53, APC and ZNF521, whereas alterations in CTNNB1, KMT2C, PTEN and SPEN were observed in neuroendocrine components only. In conclusion, TP53 is a single, frequently mutated gene in gastric NEC and MiNEN, and alterations in other genes are less common, resembling the mutation profiles of gastric adenocarcinomas. Gene mutations frequently observed in well-differentiated NET were uncommon but not entirely exclusive.Jan. 2021, Human pathology, 110, 1 - 10, English, International magazine, Co-authored internationallyScientific journal
- Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon is unclear. Our previous cDNA microarray analysis had revealed that the expression of chemokine (C-C motif) ligand 1 (CCL1) is up-regulated in peripheral blood monocyte-derived macrophages stimulated using conditioned media from ESCC cells (TAM-like macrophages). In this study, we evaluated the role of CCL1 in ESCC progression. We confirmed that CCL1 is overexpressed in TAM-like macrophages, and that CCR8, a CCL1 receptor, is expressed on ESCC cell surface. TAM-like macrophages significantly enhanced the motility of ESCC cells, and neutralizing antibodies against CCL1 or CCR8 suppressed this increased motility. Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa/mammalian target of rapamycin pathway. Phosphatidylinositol 3-kinase or Akt inhibitors, CCR8 silencing, and neutralizing antibody against CCR8 could significantly suppress these effects. The overexpression of CCL1 in stromal cells or CCR8 in ESCC cells was significantly associated with poor overall survival (P = 0.002 or P = 0.009, respectively) and disease-free survival (P = 0.009 or P = 0.047, respectively) in ESCC patients. These results indicated that the interaction between stromal CCL1 and CCR8 on cancer cells promotes ESCC progression via the Akt/proline-rich Akt substrate of 40 kDa/mammalian target of rapamycin pathway, providing novel therapeutic targets.Jan. 2021, The American journal of pathology, English, International magazineScientific journal
- Polymicrobial Solitary Retroperitoneal Abscess Due to Sigmoid Colon Perforation.We treated an 85-year-old man with an abscess perforating into the retroperitoneal space from the sigmoid colon, with retroperitoneal drainage combined with antibiotics. CT showed no abscess formation in the intraperitoneal space. The patient consulted a doctor with a chief complaint of left-side low back pain and fever. He was first diagnosed with bacteremia due to Escherichia coli and close examination by CT revealed a retroperitoneal abscess. On referral to our hospital, we determined by CT that the cause of abscess formation was perforation of the intestine into the retroperitoneal space and spreading into the psoas muscle compartment. We then performed colostomy and abscess drainage through the retroperitoneal space to prevent the abscess disseminating into the intraperitoneal space. The abscess and necrotic tissue cultures were polymicrobial, including Enterobacteriaceae and Bacteroides spp. The abscess almost disappeared after drainage, and the patient's general condition gradually improved. The retroperitoneal abscess did not relapse by follow-up CT. In conclusion, this rare case presented with perforation of the intestine (Sigmoid colon) disseminated only to the retroperitoneal space without no intraperitoneal space abscess formation. We performed drainage only by a retroperitoneal approach without entering the intraperitoneal space.Jan. 2021, The Kobe journal of medical sciences, 66(4) (4), E149-E152, English, Domestic magazineScientific journal
- BACKGROUND: Esophageal squamous cell cancer (ESCC) is one of the deadliest cancers in the world. Esophagectomy remains the principal treatment, and minimally invasive esophagectomy (MIE) has been performed worldwide. This study aimed to clarify whether the lymph node ratio (LNR), defined as the ratio of metastatic lymph nodes (LNs) to examined, is a prognostic factor for ESCC after MIE. METHODS: This study included 327 MIEs with the patient in the prone position at two institutions from 2010 to 2015. Cox proportional hazards regression analyses using clinicopathologic characteristics and the LNR were performed for the pN1 patients and the whole cohort. RESULTS: In the multivariate analysis for all stages, independent prognostic factors were depth of tumor invasion (P < 0.0001), LNR (P = 0.014), operative time (P = 0.003), and pneumonia (P = 0.012). In the analysis of the pN1 subgroup, the optimum LNR cutoff level for overall survival (OS) was 9 based on receiver operation characteristic analysis. The LNR was significantly associated with depth of tumor invasion (P = 0.004) and number of metastatic LNs (P < 0.0001). The OS curve for the group with an LNR of 9 or higher was significantly worse than for the group with an LNR lower than 9 (P < 0.001). Multivariate analyses demonstrated that the LNR is a unique independent prognostic factor for the pN1 subgroup (hazard ratio, 6.811; 95% confidence interval, 2.009-23.087; P = 0.002). CONCLUSIONS: The LNR is an independent prognostic factor in ESCC after MIE. Especially for patients with pN1 status, the LNR is more useful than the number of metastatic LNs for predicting survival outcome.Jan. 2021, Annals of surgical oncology, English, International magazineScientific journal
- BACKGROUND/AIM: Adenocarcinoma of the esophagogastric junction (AEG) is refractory even when curative resection is followed by adjuvant chemotherapy. This study evaluated the efficacy of neoadjuvant chemotherapy (NAC) using an oral fluoropyrimidine-platinum regimen for AEG. PATIENTS AND METHODS: Out of 35 patients with locally advanced AEG who underwent curative resection, 21 who underwent surgery first and 14 who received NAC were retrospectively compared in terms of survival. RESULTS: The NAC regimens comprised of S-1 or capecitabine plus oxaliplatin or cisplatin; trastuzumab was added to six borderline resectable cases. The downstaging rate was 50% and the pathological response rate including complete response (29%) was 50%. The three-year relapse-free survival in the NAC group was significantly superior than the surgery-first group (78% vs. 22%, p=0.011). The NAC group had a significantly longer median survival time than the surgery-first group (NR vs. 29 months, p=0.032). CONCLUSION: NAC using an oral fluoropyrimidine-platinum regimen may provide survival benefit in AEG.2021, Cancer diagnosis & prognosis, 1(3) (3), 185 - 191, English, International magazineScientific journal
- 医学図書出版(株), Jan. 2021, 泌尿器外科, 34(1) (1), 47 - 53, Japanese
- Jan. 2021, 消化器外科領域におけるNational Clinical Databaseの活用, 34(1) (1), 47 - 53, Japanese泌尿器外科 特集 National Clinical Database の現状[Refereed]Scientific journal
- BACKGROUND: n our previous nationwide survey report on esophageal perforation, we proposed the existence of cases with idiopathic esophageal perforation at a certain rate. AIMS: To elucidate the clinical characteristics of idiopathic esophageal perforation, we performed a comparative analysis between cases with idiopathic type and post-emetic type esophageal perforation. METHODS: This study enrolled 139 patients with esophageal perforation (post-emetic type: idiopathic type = 115:24) as the subjects of nationwide survey on esophageal perforation. We conducted detailed studies on chief complaints, inflammatory responses, initial diagnosis, location and situation of the perforation site, time to therapeutic intervention, and prognosis between the two groups. RESULTS: Compared with post-emetic type, cases of idiopathic type tended to exhibit rear-side perforation (p = 0.052) and significantly less presented chest pain (p = 0.002). Consequently, cases of idiopathic type significantly missed to diagnose as esophageal perforation compared with post-emetic type (p = 0.042). With regard to inflammatory response, cases of post-emetic type experienced hyperthermia compared with idiopathic type (p = 0.033). On the other hand, cases of idiopathic type exhibited significantly higher level of C-reactive protein than post-emetic type (p = 0.004). In addition, it took longer time until starting treatment in the cases of idiopathic type (p < 0.0001) and the cases of idiopathic type showed significantly worse prognosis than the cases of post-emetic type (p = 0.009). CONCLUSION: This study first focused on the characteristics of idiopathic esophageal perforation that have been included in so-called Boerhaave's syndrome. The pathophysiology of the idiopathic type should be separately understood from post-emetic type, because the diagnostic and prognostic features largely differ.Jan. 2021, Esophagus : official journal of the Japan Esophageal Society, English, Domestic magazineScientific journal
- Jan. 2021, Annals of gastroenterological surgery, 5(1) (1), 5 - 6, English, Domestic magazine
- Esophageal cancer has a poor prognosis despite the fact that surgical techniques have been advanced and optimized, and systemic multimodality approaches have progressed recently. Adding chemotherapy, radiotherapy, and immunotherapy to the basic surgical approach have been shown to have therapeutic benefit for esophageal cancer. This review describes the latest development of chemoradiotherapy, chemotherapy, and immunotherapy, which have contributed to the reduction in esophageal cancer growth and improved the survival of patients. Chemoradiation is a treatment option for resectable esophageal cancer to preserve the esophagus for patients who cannot tolerate surgery. Moreover, a combination of chemoradiotherapy and salvage surgery could extend the survival of patients. The effects of a triplet chemotherapy regimen are currently being verified in some Phase III studies for unresectable advanced/recurrent esophageal cancer. In addition, with the great promise of immune checkpoint inhibitors, strategies that incorporate the use of immunotherapy may shift from the metastatic setting to the neoadjuvant/adjuvant setting as a result of clinical trials. More precise comprehension of the molecular biology of esophageal cancer is expected to further control disease progression using multimodality treatments in the future.Jan. 2021, Esophagus : official journal of the Japan Esophageal Society, 18(1) (1), 25 - 32, English, Domestic magazineScientific journal
- PURPOSE: This study was conducted to determine whether establishing the proximal resection line using India ink tattooing can ensure safe resection margins during totally laparoscopic distal gastrectomy. METHODS: This retrospective study included 81 patients who underwent totally laparoscopic distal gastrectomy for gastric cancer on the lower two-thirds of the stomach. The proximal resection margins were analyzed with respect to the macroscopic type and clinical T stage, and the intraoperative appearance of the stain on the serosa was classified by reviewing surgical videos. RESULTS: R0 resection was performed in all patients. The rates of the intended margins were 89.2% in patients without a frozen section diagnosis and 84.2% in patients with differentiated type lesions who underwent a frozen section diagnosis; however, most patients with undifferentiated advanced lesions failed to achieve the intended resection margins. Intraoperative appearance revealed that 85.2% of patients had localized type stains, whereas 11.1% had widespread-type stains. CONCLUSIONS: Our procedure to determine the proximal resection line in totally laparoscopic distal gastrectomy is oncologically safe. However, careful observation of the resected specimen and a frozen section analysis should be performed for undifferentiated advanced lesions.Jan. 2021, Surgery today, 51(1) (1), 111 - 117, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. METHODS: This study analysed 317 patients who underwent minimally invasive oesophagectomy at Kobe University Hospital and Hyogo Cancer Center from 2010 to 2015. The patients' body weight was evaluated at 3 months postoperatively. They were organised into the severe weight loss (n = 65) and moderate weight loss (n = 252) groups. Furthermore, they were categorised into the FT group (184 patients who had an FT placed during oesophagectomy) and no-FT group (133 patients without FT). Patients (119 per group) matched for the FT and no-FT groups were identified via propensity score matching. RESULTS: The 5-year overall survival (OS) rate in the severe weight loss group was significantly lower (p = 0.024). In the multivariate analysis, tumour invasion depth (pT3-4), preoperative therapy and severe weight loss had a worse OS (hazard ratio = 1.89; 95% confidence interval = 1.12-3.17, hazard ratio = 2.11; 95% confidence interval = 1.25-3.54, hazard ratio = 1.82; 95% confidence interval = 1.02-3.524, respectively). No significant differences in the number of severe weight loss patients and OS were found between the FT and no-FT groups. CONCLUSION: Severe weight loss is significantly associated with poor OS. In addition, enteral nutrition via an FT did not improve the severe weight loss and OS.Dec. 2020, BMC gastroenterology, 20(1) (1), 407 - 407, English, International magazineScientific journal
- (公財)上原記念生命科学財団, Dec. 2020, 上原記念生命科学財団研究報告集, 34, 1 - 6, Japanese
- OBJECTIVE: To elucidate the association between preoperative hemoglobin A1c (HbA1c) levels and short-term outcomes after oncologic esophagectomy. SUMMARY BACKGROUND DATA: Although diabetes mellitus (DM) is associated with an increased risk of postoperative morbidity in several types of surgery, the association of DM with short-term outcomes after esophagectomy has shown conflicting results. METHODS: We analyzed 15801 patients who underwent oncologic esophagectomy between 2015 and 2017 from the National Clinical Database. We evaluated the associations between preoperative HbA1c levels and short-term outcomes, using multivariable logistic regression and restricted cubic spline models. RESULTS: The cohort included 12074, 1361, 1097, 909, and 360 patients with HbA1c levels of ≤5.9%, 6.0%-6.4%, 6.5%-6.9%, 7.0%-7.9%, and ≥8.0%, respectively. There were value-dependent associations between HbA1c values and odds ratios (ORs) for anastomotic leakage (AL), surgical site infections (SSIs), pneumonia, and composite outcomes. Compared with the HbA1c category of ≤5.9%, the categories of 7.0%-7.9% and ≥8.0% were at higher risk for AL (P <0.001 and 0.031, respectively), the category of ≥8.0% was at higher risk for SSIs (P = 0.001), the categories of 6.5%-6.9% and 7.0%-7.9% were at higher risk for pneumonia (P = 0.016 and 0.002, respectively), and the categories of 7.0-7.9 and ≥ 8.0% were at higher risk for composite outcomes (P < 0.001 and 0.001, respectively). CONCLUSIONS: Preoperative HbA1c levels are associated with the risk of postoperative complications following esophagectomy, and the threshold values differed among the outcomes. Preoperative HbA1c is useful in predicting the risk of postoperative complications.Nov. 2020, Annals of surgery, English, International magazineScientific journal
- PURPOSE: Minimally invasive esophagectomy (MIE) has been increasingly used, but many reports have stated that recurrent laryngeal nerve (RLN) palsy after MIE is a major complication associated with postoperative pneumonia. Prevention of RLN palsy clearly has been a challenging task. The study aim was to determine if a three-dimensional (3-D) stereoscopic vision system can reduce the RLN palsy rate after MIE. METHODS: This was a retrospective study of MIE (McKeown esophagectomy) using a 3-D or 2-D stereoscopic vision system to treat 358 patients in the prone position between April 2010 and March 2019. The patients who underwent 3-D MIE (3-D group) or 2-D MIE (2-D group) were matched by using propensity score matching. After matching, the perioperative outcomes were compared between the groups. RESULTS: After propensity score matching, 154 patients were analyzed (77 patients, 3-D group; 77 patients, 2-D group). There were no significant differences in the patients' baseline characteristics in the matched cohort. There were no significant differences in the rates of pneumonia (Clavien-Dindo (C-D) grade ≥ II, 3-D vs. 2-D, 11 (14%) vs. 12 (16%)), anastomotic leakage (C-D grade ≥ II, 10 (13%) vs. 18 (23%)) and mortality. The rates of left RLN palsy (C-D grade ≥ IIIa, 1 (1.3%) vs. 7 (9.1%), P = 0.029), right RLN palsy (C-D grade ≥ I, 2 (3%) vs. 8 (10%), P = 0.049), comprehensive complication index (CCI®) (8.5 vs. 14.3, P = 0.011), and postoperative hospital stay period (median: 25 vs. 30 days, P = 0.034) were significantly lower in the 3-D group than in the 2-D group, respectively. CONCLUSIONS: In MIE, the 3-D viewing system was one of the factors that reduced postoperative morbidities such as the rates of each RLN palsy and CCI®, leading to shorter postoperative hospital stay.Nov. 2020, Langenbeck's archives of surgery, English, International magazineScientific journal
- BACKGROUND: Lipomas are the most common cause of intussusception in adults. To our knowledge, however, no cases of lipoma and ectopic gastric mucosa with gastritis cystica profunda (GCP) have been reported. We report a case of intussusception caused by a small intestinal lipoma with ectopic gastric mucosa containing GCP-component cells within the inverted Meckel's diverticulum. CASE PRESENTATION: A female in her 40s underwent computed tomography for postoperative follow-up of left breast cancer. A tumor, suspected to be a lipoma, was found in the ileum. Since there were no symptoms, the patient underwent regular follow-up. However, gradual enlargement was observed, and surgery was recommended due to the risk of intussusception. After reduction via the Hutchinson technique, laparoscopically assisted partial resection of the small intestine was performed due to suspicion that the tumor was causing intussusception starting from the ileum. Histopathologic examinations revealed proliferation of mature adipose tissue in the subserosal layer, which was diagnosed as lipoma. Furthermore, adipose tissue was found in the stem area and accordingly, we diagnosed lipoma associated with the inverted Meckel's diverticulum. Moreover, gastric mucosa-like crypt epithelium and proper glandular tissue were identified in the mucosal membrane at the area of onset, and signs of gastric pit dilatation over the submucosa and crypt epithelium hyperplasia were observed. Diagnosis was ectopic gastric mucosa containing GCP component tissue. CONCLUSIONS: Intussusception in the small intestine complicated with lipoma and ectopic gastric mucosa with GCP within the Meckel's diverticulum has not been reported, demonstrating the rarity of our case.Springer Science and Business Media LLC, Nov. 2020, Surgical case reports, 6(1) (1), 286 - 286, English, International magazineScientific journal
- Aim: The advantages of laparoscopic right hemicolectomy over open surgery for colon cancer in general clinical practice are debated, as evidenced by the continued use of open surgery in a significant proportion of patients worldwide. This study aimed to assess and compare the clinical outcome of laparoscopic and open right hemicolectomy for colon cancer using data from the Japanese National Clinical Database. Methods: A total of 72 299 patients who underwent laparoscopic (n = 46 084) and open (n = 26 215) right hemicolectomy for colon cancer between 2014 and 2018 were enrolled in this retrospective study. Short-term outcome was compared between groups using propensity score matching analysis. Results: The incidence of overall postoperative morbidity ≥ Clavien-Dindo classification grade 3 was significantly higher in the open surgery group than the laparoscopic group (4.7% vs 3.2%, P < .001). The incidence of most individual morbidities, including surgical site infection, anastomotic leakage, and ileus, was higher in the open surgery group. Short-term outcomes, including intraoperative blood loss, postoperative hospital stay, reoperation rate, 30-day mortality, and in-hospital mortality, were superior in the laparoscopic group, except for operative time. Subgroup analyses showed that the incidence of postoperative morbidity was lower in the laparoscopic group for all prespecified subgroups. Conclusion: Laparoscopic right hemicolectomy has an advantage over open surgery for colon cancer with respect to short-term outcome.Nov. 2020, Annals of gastroenterological surgery, 4(6) (6), 693 - 700, English, Domestic magazineScientific journal
- Aim: This study aimed to evaluate the association between surgeons certified via the Endoscopic Surgical Skill Qualification System (ESSQS) of the Japan Society for Endoscopic Surgery (JSES) and surgical outcomes of laparoscopic distal gastrectomy (LDG) and laparoscopic low anterior resection (LLAR). Methods: Japanese National Clinical Database data on the patients undergoing LDG and LLAR between 2014-2016 were analyzed retrospectively. The proportion of cases performed by ESSQS-certified surgeons was calculated for each procedure, and clinicopathological factors with or without participation of ESSQS-certified surgeons as an operator were assessed. Then, effects of operations performed by ESSQS-certified surgeons on short-term patient outcomes were analyzed using generalized estimating equations logistic regression analysis. Results: There were 110 610 and 65 717 patients who underwent LDG and LLAR, respectively. The operations performed by ESSQS-certified surgeons in each procedure totaled 28 467 (35.3%) and 12 866 (31.2%), respectively. A multivariable logistic regression model showed that odds ratios of mortality for LDG and LLAR performed by ESSQS-certified surgeons were 0.774 (95% CI, 0.566-1.060, P = 0.108) and 0.977 (0.591-1.301, P = 0.514), respectively. Odds ratios for secondary endpoints of anastomotic leakage in LDG and LLAR performed by ESSQS-certified surgeons were 0.835 (95% CI, 0.723-0.964, P = 0.014) and 0.929 (0.860-1.003, P = 0.059), respectively, whereas that of ileus/bowel obstruction for LLAR performed by ESSQS-certified surgeons was 1.265 (1.132-1.415, P < 0.001). There were no significant associations between the two operations performed by ESSQS-certified surgeons and other factors such as mortality and overall complications. Conclusions: ESSQS certification did not affect postoperative mortality following LDG and LLAR, but annual experience of laparoscopic surgery was associated with it. ESSQS certification may contribute to favorable outcomes regarding anastomotic leakage following LDG and LLAR.Nov. 2020, Annals of gastroenterological surgery, 4(6) (6), 721 - 734, English, Domestic magazineScientific journal
- BACKGROUND: Omentoplasty is sometimes used to prevent perineal wound complications after abdominoperineal resection (APR) following neoadjuvant chemoradiotherapy (NACRT). However, recent studies have raised some controversy about its clinical benefit. PATIENTS AND METHODS: Outcomes for rectal cancer patients who received APR after NACRT were retrospectively compared between the groups with omentoplasty (n=28) and without omentoplasty (n=14). RESULTS: The operative time was significantly longer in the omentoplasty group (575 vs. 404 min, p<0.001). Laparoscopic surgery was performed more frequently in the omentoplasty group. Perineal wound problems including dehiscence and infection were significantly reduced in the omentoplasty group (46.4% vs. 78.6%, p<0.001). Univariate and multivariate analyses revealed that omentoplasty was the most important factor in reducing perineal wound complications (odds ratio=0.020, 95% confidence intervaI=0.001-0.393; p=0.001). CONCLUSION: Omentoplasty was useful in reducing perineal wound complications after APR following NACRT.Nov. 2020, Anticancer research, 40(11) (11), 6539 - 6543, English, International magazineScientific journal
- BACKGROUND: No guidelines are available for defining the extent of lymph node (LN) dissection in patients with remnant gastric carcinoma (RGC). Hence, this retrospective study aimed to determine the optimal extent of LN dissection in patients with RGC. METHODS: We retrospectively evaluated the therapeutic outcomes of node dissection for RGC from a nationwide registry. When the metastatic rate or 5-year survival rate exceeded 10%, dissection was recommended. We calculated the dissection index by multiplying the incidence of metastasis at that nodal station by the 5-year survival rate of patients with metastasis at the station. A dissection index of > 1.0 was considered significant. RESULTS: We included 1133 patients with RGC (T2-T4 tumor) who had undergone distal gastrectomy as the primary surgery for the evaluation of the survival benefit of nodal dissection. Any regional node station was considered significant. When the primary surgery was for malignant disease, the index was high for Nos. 3 (10.2), 7 (9.5), 1 (7.1), and 9 (8.0) nodes. For nodes at the splenic hilum, the index value was 4.4, which was higher than that for the perigastric nodes (Nos. 4sa and 4sb). The index for No. 10 nodes was the highest (10.5) when tumors involved a greater curvature. CONCLUSIONS: The therapeutic strategy for RGC remains the same, regardless of the histology of the primary disease during the initial surgery. Total gastrectomy and dissection of the perigastric LNs (Nos. 1-4), suprapancreatic LNs (Nos. 7-9 and 11), and LNs at the splenic hilum (No. 10) are justified.Nov. 2020, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23(6) (6), 1091 - 1101, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Three-dimensional (3-D) high-definition (HD) stereovision and two-dimensional (2-D) ultra-high-resolution (4K) monitors have recently become available for laparoscopic surgery. The aim of this study was to compare laparoscopic performance between inexperienced participants using 3-D/HD and 2-D/4K monitors and those using conventional 2-D/HD monitors. METHODS: The study enrolled 66 participants with no previous surgical experience or medical training. They were randomly divided into three equal groups, each using a different type of monitor (2-D/HD, 2-D/4K, or 3-D/HD), to perform three phantom tasks using a laparoscopic simulator: Task 1, touching markers on a non-flat surface; Task 2, bimanual peg transfer; and Task 3, passing a straight rod through a loop. Each task was performed three times. The performance scores (operative time, path length of the forceps, and technical errors) were compared for each monitor type and by age group (< 30 vs. > 30 years). RESULTS: For all three tasks, scores using the 3-D monitor were significantly better than those using either 2-D monitor, with no difference between the 2-D/4K and 2-D/HD monitors. Using the 2-D monitors, the performance of Task 3 by the participants > 30 years was worse than that by the younger participants; however, there was no difference between the age groups when using the 3-D monitor. CONCLUSION: Participants with no prior experience using a 3-D monitor showed better laparoscopic performance than those using 2-D monitors, even with 4K resolution. This improvement was more marked in older participants, suggesting a greater loss of depth perception in a 2-D environment.Nov. 2020, Surgical endoscopy, 34(11) (11), 5083 - 5091, English, International magazine, Co-authored internationally[Refereed]Scientific journal
- OBJECTIVES: To investigate the effect of geriatric variables on five newly added outcomes and create risk models for predicting these outcomes. SUMMARY BACKGROUND DATA: Because there is a current lack of geriatric research focusing on geriatric outcomes using a national surgical database in Japan, there is a need to investigate outcomes associated with major gastroenterological surgery using these data. METHODS: This multicenter prospective cohort study was conducted at 26 surgery departments across 21 institutions in Japan using the National Clinical Database (NCD) surgical registry. In total, 22 new geriatric variables were imported from the ACS NSQIP geriatric pilot study. The following five geriatric outcomes were defined: 1) postoperative delirium, 2) physical function on postoperative day 30, 3) fall risk on discharge, 4) discharge other than home with social service, and 5) functional decline on discharge, and geriatric risk prediction models for major gastroenterological surgery were created. RESULTS: Between January 2018 and December 2018, data on 3,981 procedures from seven major gastroenterological surgeries were collected and analyzed. Older age and preoperative geriatric variables (Origin status from home, History of dementia, Use of mobility aid, Fall history, and Not competent on admission) were strongly associated with postoperative outcomes. Geriatric risk prediction models for these outcomes were created, with C-statistic values ranging from 0.74 to 0.90, demonstrating model validity and sufficiency of fit. CONCLUSIONS: The risk models for the newly defined five geriatric outcomes that we created can be used in the decision-making process or provision of care in geriatric patients.Oct. 2020, Annals of surgery, 275(6) (6), 1112 - 1120, English, International magazineScientific journal
- Wiley, Oct. 2020, Journal of Gastroenterology and Hepatology, 35(10) (10), 1667 - 1667, English, International magazineScientific journal
- In the original publication of the article, the following errors were noted and corrected in this correction.Oct. 2020, Journal of gastroenterology, 55(10) (10), 1010 - 1011, English, Domestic magazine
- PURPOSES: The aim of this study was to clarify the impact of a board certification system and the implementation of clinical practice guidelines for pancreatic cancer (PC) on the mortality of pancreaticoduodenectomy in Japan. METHODS: By a web questionnaire survey via the National Clinical Database (NCD) for departments participating in the NCD, quality indicators (QIs) related to the treatment for PC, namely the board certification systems of various societies and the adherence to clinical practice guidelines for PC, were investigated between October 2014 and January 2015. A multivariable logistic regression analysis was performed to evaluate the relationship between the QIs and mortality of pancreaticoduodenectomy. RESULTS: Of 1415 departments that registered at least 1 pancreaticoduodenectomy between 2013 and 2014 in NCD, 631 departments (44.6%), which performed pancreaticoduodenectomy for a total of 11,684 cases, answered the questionnaire. The mortality of pancreaticoduodenectomy was positively affected by the board certification systems of the Japanese Society of Gastroenterological Surgery, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Japanese Society of Gastroenterology, and Japanese Society of Medical Oncology as well as by institutions that used magnetic resonance imaging of ≥ 3 T for the diagnosis of PC in principle. CONCLUSIONS: The measurement of the appropriate QIs is suggested to help improve the mortality in pancreaticoduodenectomy. Masamichi Mizuma and Hiroyuki Yamamoto equally contributed.Oct. 2020, Surgery today, 50(10) (10), 1297 - 1307, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND/PURPOSE: The aim of this study was to identify risk factors for bile leakage in hepatic resections without biliary reconstructions using the large Japanese national clinical database (NCD). METHODS: A total of 10 102 patients who had undergone hepatic resection involving more than one segment without biliary reconstructions for hepatocellular carcinoma during 2015-2017 were enrolled. Risk factors for bile leakage, with special reference to the type of hepatic resection, were identified by multivariable logistic regression analysis. RESULTS: Bile leakage occurred in 726 patients (7.2%). Risk factors for bile leakage were as follows: male sex (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.04-1.58), diabetes mellitus (+) (OR 1.19, 95% CI 1.01-1.39), hemoglobin <10 g/dL (OR 1.4, 95% CI 1.02-1.93), albumin <3.5 g/dL (OR 1.3, 95% CI 1.03-1.63), central bisectionectomy (OR 3.8, 95% CI 2.81-5.13), left trisectionectomy (OR 3.6, 95% CI 2.10-6.15), right anterior sectionectomy (OR 2.07, 95% CI 1.58-2.72), and S5 or S8 segmentectomy (OR 1.33, 95% CI 1.00-1.77). CONCLUSION: Central bisectionectomy, left trisectionectomy, and right anterior sectionectomy are high-risk types of hepatic resection for bile leakage.Sep. 2020, Journal of hepato-biliary-pancreatic sciences, English, Domestic magazineScientific journal
- The number of elderly patients with esophageal cancer has increased in recent years. The use of thoracoscopic esophagectomy has also increased, and its minimal invasiveness is believed to contribute to postoperative outcomes. However, the short- and long-term outcomes in elderly patients remain unclear. This study aimed to elucidate the safety and feasibility of minimally invasive esophagectomy in elderly patients. This retrospective study included 207 patients who underwent radical thoracoscopic esophagectomy for thoracic esophageal squamous cell carcinoma at Kobe University Hospital between 2005 and 2014. Patients were divided into non-elderly (<75 years) and elderly (≥75 years) groups. A propensity score matching analysis was performed for sex and clinical T and N stage, with a total of 29 matched pairs. General preoperative data, surgical procedures, intraoperative data, postoperative complications, in-hospital death, cancer-specific survival, and overall survival were compared between groups. The elderly group was characterized by lower preoperative serum albumin levels and higher American Society of Anesthesiologists grade. Intraoperative data and postoperative complications did not differ between the groups. The in-hospital death rate was 4% in the elderly group, which did not significantly differ from the non-elderly group. Cancer-specific survival was similar between the two groups. Although overall survival tended to be poor in the elderly group, it was not significantly worse than that of the non-elderly group. In conclusion, the short- and long-term outcomes of minimally invasive esophagectomy in elderly versus non-elderly patients were acceptable. Minimally invasive esophagectomy is a safe and feasible modality for elderly patients with appropriate indications.Sep. 2020, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, English, International magazineScientific journal
- (株)医学書院, Sep. 2020, 臨床外科, 75(9) (9), 1056 - 1061, Japanese
- Laparoscopic right hemicolectomy (LRH) is utilized worldwide as one of the standard surgical treatments for right-sided colon cancer. However, there have been issues concerning its applicability, techniques, and trend. The present study aimed to elucidate the current status and trend of LRH by reviewing literature focusing on important issues associated with this surgery. Based on previous studies, LRH most likely provides better short-term outcomes and similar oncological outcomes compared to open surgery. Despite the increasing use of robotic approach in this surgery, it seems to have always been associated with longer operative times and greater hospital cost with limited advantage. Intracorporeal anastomosis seems to improve short-term outcomes, such as quicker recovery of bowel function, compared to extracorporeal anastomosis. However, it does not contribute to shorter hospital stay. With regard to dissection technique, various approaches, and landmarks have been advocated to overcome the technical difficulty in LRH. This difficulty is likely to be caused by anatomical variation, especially in venous structures. The superiority of one approach or landmark over another is still argued about due to the lack of large-scale prospective studies. However, deep understanding both of anatomical variation and characteristics of each approach would be of extreme importance to minimize adverse effects and maximize patient benefit after LRH.Sep. 2020, Annals of gastroenterological surgery, 4(5) (5), 521 - 527, English, Domestic magazineScientific journal
- Background: Emergency gastrointestinal surgery, although rare, is known for its high mortality and morbidity. However, the risks of emergency surgery for gastrointestinal cancer have not been investigated in depth. This study aimed to investigate the impact of emergency surgery on mortality and morbidity in patients with gastrointestinal cancers and to identify associated risk factors. Methods: We extracted data from the National Clinical Database, a nationwide surgery registration system in Japan, for patients with gastrointestinal cancer who underwent esophageal resection, total gastrectomy, distal gastrectomy, right hemicolectomy, or low anterior resection between 2012 and 2017. The impacts of emergency surgery on 30-day mortality and incidence of overall postoperative complications were compared with those of non-emergency surgery. Risk factors for mortality and overall postoperative complications were then sought in patients who underwent emergency surgery. Results: Thirty-day mortality and incidence of overall postoperative complications were significantly higher in emergency surgeries for gastric, colon, and rectal cancers than in non-emergency surgeries (odds ratios 4.86-6.98 and 1.68-2.18, respectively; all P < .001). Various risk factors were identified in the group that underwent emergency surgery, including preoperative sepsis and lower body mass index. Some of the risk factors were common to all types of surgery and others were specific to a certain type of surgery. Conclusion: The actual risk of emergency surgery and the risk factors for overall postoperative complications in emergency cases are shown to serve as a reference for postoperative management. Emergency surgery had an additional burden on patients depending on the type of surgery.Sep. 2020, Annals of gastroenterological surgery, 4(5) (5), 549 - 561, English, Domestic magazineScientific journal
- (一社)日本外科学会, Aug. 2020, 日本外科学会定期学術集会抄録集, 120回, SP - 2, JapaneseACS-NSQIPに学ぶ、外科医療成績向上に向けた取り組み
- (一社)日本消化器外科学会, Aug. 2020, 日本消化器外科学会雑誌, 53(8) (8), 617 - 626, Japanese
- BACKGROUND: The esophagus is known to be derived from the foregut. However, the mechanisms regulating this process remain unclear. In particular, the details of the human esophagus itself have been poorly researched. In this decade, studies using human induced pluripotent stem cells (hiPSCs) have proven powerful tools for clarifying the developmental biology of various human organs. Several studies using hiPSCs have demonstrated that retinoic acid (RA) signaling promotes the differentiation of foregut into tissues such as lung and pancreas. However, the effect of RA signaling on the differentiation of foregut into esophagus remains unclear. METHODS: We established a novel stepwise protocol with transwell culture and an air-liquid interface system for esophageal epithelial cell (EEC) differentiation from hiPSCs. We then evaluated the effect of all-trans retinoic acid (ATRA), which is a retinoic acid receptor (RAR)α, RARβ and RARγ agonist, on the differentiation from the hiPSC-derived foregut. Finally, to identify which RAR subtype was involved in the differentiation, we used synthetic agonists and antagonists of RARα and RARγ, which are known to be expressed in esophagus. RESULTS: We successfully generated stratified layers of cells expressing EEC marker genes that were positive for lugol staining. The enhancing effect of ATRA on EEC differentiation was clearly demonstrated with quantitative reverse transcription polymerase chain reaction, immunohistology, lugol-staining and RNA sequencing analyses. RARγ agonist and antagonist enhanced and suppressed EEC differentiation, respectively. RARα agonist had no effect on the differentiation. CONCLUSION: We revealed that RARγ activation promotes the differentiation of hiPSCs-derived foregut into EECs.Aug. 2020, Journal of gastroenterology, 55(8) (8), 763 - 774, English, Domestic magazine[Refereed]Scientific journal
- The Japanese Journal of Gastroenterological Surgery, Jul. 2020, The Japanese Journal of Gastroenterological Surgery, 53(7) (7), 598 - 604Scientific journal
- (一社)日本膵臓学会, Jul. 2020, 膵臓, 35(3) (3), A119 - A119, Japanese膵全摘術の現状と展望 National clinical databaseによる膵全摘術の術後重症合併症リスクモデル
- (株)メディカルレビュー社, Jul. 2020, 胃がんperspective, 11(2) (2), 124 - 127, Japaneseエキスパートの治療法 症例から考える 4型胃癌の治療方針
- Jul. 2020, 外科臨床に役立つ統計学, 82(8) (8), 830 - 835, JapaneseNational Clinical Databaseから何が引き出せるか[Refereed]Scientific journal
- PURPOSE: The influence of anastomotic leakage on long-term survival in patients with rectal cancer is debatable. The aim of this study was to evaluate relationships between anastomotic leakage and long-term survival. METHODS: In this multicenter retrospective cohort study, 395 consecutive stage I to III rectal cancer patients underwent anterior resection between 2007 and 2012. Five-year overall survival, 5-year disease-free survival, and 5-year local recurrence-free survival were compared between patients with leakage (Leakage (+)) and patients without leakage (Leakage (-)). RESULTS: Of 395 patients, 50 (12.7%) had anastomotic leakage. Of these 50, 34 (68.0%) required urgent surgery and 16 (32.0%) could be managed by watchful waiting or with percutaneous drainage. The median follow-up period was 62.6 months. Five-year overall survival did not differ between the two groups (Leakage (+) 93.8% vs. Leakage (-) 89.0%, P = 0.121). Five-year disease-free survival also did not differ between the two groups (81.6% vs. 80.3%, P = 0.731), and neither did 5-year local recurrence-free survival (91.9% vs. 86.1%, P = 0.206). In a multivariable Cox regression model, BMI > 25, preoperative CA19-9 > 37, pathological T stage, pathological N stage, and circumferential resection margin (CRM) positive were independent predictors of disease-free survival. Moreover, pathological T stage, pathological N stage, and CRM positive were the only independent predictors of overall survival and local recurrence-free survival. Anastomotic leakage was not a risk factor for overall survival, disease-free survival, or local recurrence-free survival. CONCLUSION: Anastomotic leakage is not associated with a significant decrease in long-term survival in rectal cancer patients.Jul. 2020, International journal of colorectal disease, 35(7) (7), 1243 - 1253, English, International magazine[Refereed]Scientific journal
- OBJECTIVE: To get a clear view of the current state of treatment for esophageal perforation in Japan. Esophagus perforations are the most serious gastrointestinal tract perforations and are associated with high morbidity and mortality. The optimal treatment choice remains unknown. METHODS: We conducted a retrospective clinical review of 182 esophageal perforation cases at 108 hospitals accredited by the Japanese Esophageal Society between January 2010 and December 2015. RESULTS: We found that 20.9% of patients were incorrectly diagnosed initially. We observed mediastinum emphysema in 83.5% of patients, and serious abscess formations of the mediastinum and intrathoracic cavity in 38.6% and 29.6%, respectively. The lower esophagus was the most commonly perforated site (77.7%). Management of esophageal perforations included nonoperative treatment in 20 patients (11%) and operative treatment in 162 patients (89%). The overall mortality rate was 6.9%. The survivors had significantly shorter times from symptom appearance to visit (p = 0.0016), and from time to visit to diagnosis confirmation (p = 0.0011). Moreover, patients older than 65 years, white blood cells less than 3000/mm3, C-reactive protein > 10 mg/L, or abscesses in the thoracic cavity showed significantly higher mortality than others. CONCLUSION: Shortening the time from onset to the start of treatment contributes to reduce mortality in patients with esophageal perforation. Moreover, strict medical treatment is necessary to lower the mortality rate of elderly patients with strong inflammation and abscesses in the thoracic cavity.Jul. 2020, Esophagus : official journal of the Japan Esophageal Society, 17(3) (3), 230 - 238, English, Domestic magazine[Refereed]Scientific journal
- PURPOSE: Skeletal muscle loss after gastrectomy can worsen patients' quality of life and prognosis. Laparoscopic gastrectomy is less invasive than open gastrectomy and has become commonly performed. However, the degree of skeletal muscle loss after laparoscopic procedures remains unclear. We herein report the degree and risk factors of psoas muscle loss after laparoscopic gastrectomy for gastric cancer. METHODS: The total psoas area (TPA) on computed tomography of 50 consecutive patients who underwent laparoscopic total gastrectomy (LTG) and 167 consecutive patients who underwent laparoscopic distal gastrectomy (LDG) for gastric cancer was retrospectively evaluated at one postoperative year. The TPA loss was compared between LDG and LTG and univariate and multivariate analyses were performed to identify the risk factors for TPA loss > 10%. RESULTS: The median TPA decrease rate was 5.9% in the LDG group and 15.6% in the LTG group. LTG and postoperative respiratory complications were independent factors associated with a severe TPA loss of > 10%. In the LTG group, no independent factors were identified in a multivariate analysis. In the LDG group, postoperative complications were identified as an independent risk factor for TPA loss > 10%. CONCLUSIONS: Laparoscopic gastrectomy leads to postoperative TPA loss, especially in patients who underwent LTG and had postoperative respiratory complications. Postoperative complications after LDG were also a risk factor for TPA loss.Jul. 2020, Surgery today, 50(7) (7), 693 - 702, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Laparoscopic surgery has become popular for colorectal cancer treatment in recent years. However, its success rate even among high-risk patients remains debatable. The present study aims to compare the short- and long-term outcomes between laparoscopic and open surgeries in the American Society of Anesthesiologists (ASA) classes 3 and 4 patients with colorectal cancer. METHODS: This was a single-center, retrospective, cohort study performed at a university hospital, with 78 patients suffering from colorectal cancer who underwent surgery in ASA classes 3 and 4 as respondents. Patient and tumor characteristics, operative outcomes, and prognoses were factors compared between the open and laparoscopic groups. RESULTS: Compared with the open group, laparoscopic group had longer operation time (median 287.5 vs 204.5 minutes, P = .001), less operative blood loss (median 40 vs 240 mL, P = .020), and fewer postoperative complications (24% vs 55%, P = .011). In addition, operative approach (open vs laparoscopic) served as an independent factor for the occurrence of postoperative complications [HR = 3.963 (1.344-12.269), P = .013]. In terms of overall survival and recurrence-free survival (P = .171 and .087, respectively), no significant difference was found between the two groups. CONCLUSION: Laparoscopic surgery is thus associated with more favorable short-time outcomes and could be adopted as treatment even for colorectal cancer ASA class 3 and 4 patients.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 336 - 342, English, Domestic magazine[Refereed]Scientific journal
- OBJECTIVE: We aimed to elucidate whether minimally invasive esophagectomy (MIE) can be safely performed by reviewing the Japanese National Clinical Database. SUMMARY OF BACKGROUND DATA: MIE is being increasingly adopted, even for advanced esophageal cancer that requires various preoperative treatments. However, the superiority of MIE's short-term outcomes compared with those of open esophagectomy (OE) has not been definitively established in general clinical practice. METHODS: This study included 24,233 esophagectomies for esophageal cancer conducted between 2012 and 2016. Esophagectomy for clinical T4 and M1 stages, urgent esophagectomy, 2-stage esophagectomy, and R2 resection were excluded. The effects of preoperative treatment and surgery on short-term outcomes were analyzed using generalized estimating equations logistic regression analysis. RESULTS: MIE was superior or equivalent to OE in terms of the incidence of most postoperative morbidities and surgery-related mortality, regardless of the type of preoperative treatment. Notably, MIE performed with no preoperative treatment was associated with significantly less incidence of any pulmonary morbidities, prolonged ventilation ≥48 hours, unplanned intubation, surgical site infection, and sepsis. However, reoperation within 30 days in patients with no preoperative treatment was frequently observed after MIE. The total surgery-related mortality rates of MIE and OE were 1.7% and 2.4%, respectively (P < 0.001). Increasing age, low preoperative activities of daily living, American Society of Anesthesiologists physical status ≥3, diabetes mellitus requiring insulin use, chronic obstructive pulmonary disease, congestive heart failure, creatinine ≥1.2 mg/dL, and lower hospital case volume were identified as independent risk factors for surgery-related mortality. CONCLUSIONS: The results suggest that MIE can replace OE in various situations from the perspective of short-term outcome.Jul. 2020, Annals of surgery, 272(1) (1), 118 - 124, English, International magazine[Refereed]Scientific journal
- INTRODUCTION: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR-S). MATERIALS AND SURGICAL TECHNIQUE: A 75-year-old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection. DISCUSSION: TRGR-S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR-S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 461 - 464, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Three-dimensional (3D) laparoscopic vision can improve depth perception. However, it is a question whether 3D vision can improve motion in the depth direction. The aim of this study was to compare the impact of 3D vision on forceps motion in the depth and horizontal directions. METHODS: All data were obtained from our previous two studies, where, in total, 40 novices and 20 moderately experienced surgeons participated. A simple phantom task was performed in a training box. The participants were randomly assigned to two groups. Specifically, one group performed the task five times initially under a two-dimensional (2D) system, and the other group started under a 3D system. Both groups then performed the same task five times under the alternative system. Performances were recorded by an optical position tracker. We separately evaluated forceps motion in the x-, y-, and z-axis directions. RESULTS: Compared with the findings for 2D vision, the forceps path lengths were significantly decreased among novices and moderately experienced surgeons in almost all tasks under 3D vision. In a comparison of the path length ratio (3D/2D) in each direction, larger reduction was observed for the depth direction among novices, whereas no significant directional difference was noted among moderately experienced surgeons. CONCLUSIONS: For novices, 3D laparoscopic vision improves depth perception and may give shorter forceps movement in the depth direction even for simple tasks.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 265 - 271, English, Domestic magazine[Refereed]Scientific journal
- Retroperitoneal cellular angiofibroma (RCA) is very rare, and the optimal treatment for RCA has not been established. We report the case of RCA in a 58-year-old man who underwent curative laparoscopy-assisted resection. Preoperative computed tomography showed heterogeneous enhancement of the 7 cm diameter tumor in the pelvis. A smaller (2.3 cm) mass was also detected in the small intestine. The preoperative diagnosis was peritoneal metastasis of the gastrointestinal tumor of the small intestine. The pelvic tumor was laparoscopically mobilized from the rectum, the left ureter, and the left internal iliac vessels. The tumor was excised by detachment from the urinary bladder in laparotomy. The pathological diagnosis was RCA. The tumor had not recurred by the 1-year follow-up. The laparoscopic approach thus might be useful for resection of RCA.Jul. 2020, Asian journal of endoscopic surgery, 13(3) (3), 431 - 434, English, Domestic magazine[Refereed]Scientific journal
- Jun. 2020, Diseases of the colon and rectum, 63(6) (6), 859 - 859, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Adjuvant chemotherapy is an accepted treatment to improve survival rates in patients with stage III colon cancer, and regimens including oxaliplatin have been shown to be superior to those containing 5-FU alone. The purpose of this study was to examine the efficacy and feasibility of S-1 plus oxaliplatin (C-SOX) as adjuvant chemotherapy for patients with stage III colon cancer following curative resection. METHODS: Patients with colon cancer who underwent curative resection were enrolled and received oral S-1 40-60 mg twice daily on days 1-14 every 3 weeks plus intravenous oxaliplatin 130 mg/m2 on day 1 for eight courses. The primary endpoint was 3-year disease-free survival rate. Secondary endpoints were the rate of treatment completion, adverse events, relative dose intensity, and overall survival. RESULTS: Between February 2014 and December 2014, 89 patients were enrolled. One patient was excluded from the analysis because of ineligibility, and the remaining 88 patients were included. The rate of protocol treatment completion was 72.3%. The relative dose intensity of S-1 and oxaliplatin was 72% and 76.3%, respectively. Hematological severe adverse events (Grade 3/4) were neutropenia (21.3%) and thrombocytopenia (15.7%). The most frequent symptom was diarrhea (Grade 3/4: 5.6%). The incidence of grade 2 neuropathy has decreased from 8.1 to 2.7% after 3 years of the therapy. Three-year disease-free survival rate was 73.9% (95% CI 63.8-81.9), and 3-year overall survival rate was 94.3% (95% CI 86.8-97.6) CONCLUSIONS: C-SOX is a safe and feasible adjuvant chemotherapy regimen in patients with stage III colon cancer undergoing curative resection.Jun. 2020, International journal of clinical oncology, 25(6) (6), 1115 - 1122, English, Domestic magazine[Refereed]Scientific journal
- Cancer cells with cancer stem cell (CSC) properties initiate both primary tumor formation and metastases at distant sites. Acquisition of CSC properties is highly associated with epigenetic alterations, including those mediated by microRNAs (miRNAs). We have previously established the breast cancer patient-derived tumor xenograft (PDX) mouse model in which CSC marker CD44+ cancer cells formed spontaneous microscopic metastases in the liver. In this PDX mouse, we found that the expression levels of 3 miRNAs (miR-25, miR-93, and miR-106b) in the miR-106b-25 cluster were much lower in the CD44+ human cancer cells metastasized to the liver than those at the primary site. Constitutive overexpression of miR-93 suppressed invasive ability and 3D-organoid formation capacity of breast cancer cells in vitro and significantly suppressed their metastatic ability to the liver in vivo. Wiskott-Aldrich syndrome protein family member 3 (WASF3), a regulator of both cytoskeleton remodeling and CSC properties, was identified as a functional target of miR-93: overexpression of miR-93 reduced the protein level of WASF3 in breast cancer cells and WASF3 rescued the miR-93-mediated suppression of breast cancer cell invasion. These findings suggest that miR-93 functions as a metastasis suppressor by suppressing both invasion ability and CSC properties in breast cancers.Jun. 2020, Cancer science, 111(6) (6), 2093 - 2103, English, International magazine[Refereed]Scientific journal
- BACKGROUND: We report a rare case of gastrointestinal stromal tumors (GISTs) in Carney's triad, successfully treated using laparoscopic gastrectomy with lymph node dissection after chemotherapy. CASE PRESENTATION: A 21-year-old woman presented to our hospital for treatment of recurrent GISTs. The patient had been admitted for treatment 11 years prior, with black stools being the chief presenting complaint at that time. On examination at that time, multiple submucosal tumors in the pyloric antrum and multiple pulmonary tumors had been observed. She underwent open partial gastrectomy, and the diagnosis of GISTs was confirmed. She was administered tyrosine kinase inhibitors to treat lung metastases from 2 months after surgery. Due to the increasing size of the lung tumors, a right upper lobectomy was performed 9 years after the index gastric surgery. Histopathological examination of the lung specimen, in combination with re-examination of the gastric specimens, was indicative of incomplete-type Carney's triad. Eleven years after the index gastric surgery, multiple GISTs were observed in her entire stomach. Tumor biopsy revealed a succinate dehydrogenase deficiency, confirming the diagnosis of recurrent GISTs. For treatment, the patient underwent laparoscopic completion gastrectomy, with D1 plus lymph node dissection. CONCLUSION: This is a first case report of completion gastrectomy performed laparoscopically for the treatment of GISTs associated with incomplete-type Carney's triad. The recurrent GISTs developed over a protracted period of 11 years from the index gastric surgery to tumor recurrence.May 2020, Surgical case reports, 6(1) (1), 112 - 112, English, International magazine[Refereed]Scientific journal
- Aim: To investigate the effectiveness of the institutional medical structure and of the implemented clinical practice guidelines for improving colon cancer surgical outcomes. Methods: We conducted a web-based questionnaire survey among departments registered at the National Clinical Database in Japan from October 2014 to January 2015 to assess the association between quality indicators (QIs), including structure and process indicators (clinical practice guideline adherence), and the risk-adjusted odds ratio for operative mortality (AOR) after right hemicolectomy for colorectal cancer during the study period. Results: Among the 2064 departments registering at least one colorectal surgery during the study period, we obtained responses from 814 departments (39.4%). Our analysis on data from 22 816 patients with right hemicolectomy demonstrated that three structural QIs (certification of training hospitals by the Japanese Society of Gastroenterological Surgery and the presences of board-certified gastroenterological and colorectal surgeons) were associated with significantly lower AOR (P < .001, P = .02, and P = .05, respectively). The "performed at the doctor's discretion" answer was associated with poorer short-term outcomes in six process QIs than other answers. Conclusion: The board certification system for gastroenterological and colorectal surgeons and the adherence to the clinical guidelines improve the operative mortality after right hemicolectomy. It is desired to clarify the most suitable QIs to reduce the operative mortality after colorectal surgery.May 2020, Annals of gastroenterological surgery, 4(3) (3), 283 - 293, English, Domestic magazine[Refereed]Scientific journal
- The National Clinical Database (NCD) of Japan grew rapidly, harvesting over 11 million cases of data between 2011 and 2018 from more than 5000 facilities. This is the Report of the NCD based upon gastrointestinal surgery information in 4 420 175 cases from 2011 to 2018. More than 70% of all gastrointestinal surgeries were performed at certified institutions, and the percentage of surgeries performed at certified institutions was particularly high for the esophagus (93.8% in 2018), liver (89.4%), pancreas (91.3%), and spleen (86.9%). Also, more than 70% of the surgeries were performed with the participation of the board-certified surgeon. As the patients have been getting older, the morbidities have been increasing. However, the mortalities have been kept at a low level. The rates of endoscopic surgery have been increasing year by year, especially high in low anterior resection (67.0%) and esophagectomy (61.0%). Nationwide, this database is surely expecting to ensure the quality of board certification system and surgical outcomes in gastroenterological surgery.May 2020, Annals of gastroenterological surgery, 4(3) (3), 250 - 274, English, Domestic magazine[Refereed]Scientific journal
- May 2020, BRITISH JOURNAL OF SURGERY, 107(6) (6), 734 - 742, English, International magazine[Refereed]Scientific journal
- Autoimmune hemolytic anemia (AIHA) is a rare comorbidity in colorectal cancer (CRC) and has an unknown etiology. Previously, we described an AIHA case secondary to CRC with ectopic band 3 expression. Herein, we investigated ectopic band 3 expression and erythrocyte membrane-bound IgG in a CRC cohort. Between September 2016 and August 2018, 50 patients with CRC and 26 healthy controls were enrolled in the present study. The expression of band 3 and SLC4A1 mRNA was observed in 97% of CRC surgical specimens. Although clinical AIHA was not observed in any patient with CRC, a direct antiglobulin test was positive in 10 of the patients in the CRC group (p = 0.01). Flow cytometry revealed significantly increased erythrocyte membrane-bound IgG among patients with CRC compared to healthy controls (mean ± standard deviation; 38.8 ± 4.7 vs. 29.9 ± 15.6, p = 0.012). Normocytic anemia was observed, including in cases negative for fecal occult blood, suggesting a shortened erythrocyte life-span due to increased membrane-bound IgG. Immunoprecipitation revealed increased anti-band 3 autoantibodies in patients' sera. Mouse experiments recapitulated this phenomenon. We also confirmed that band 3 expression is controlled by 5'AMP-activated protein kinase under hypoxic conditions. These findings increase our understanding of the etiology of cancer-related anemia.May 2020, International journal of hematology, 111(5) (5), 657 - 666, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: The common use of laparoscopic intervention produces impressive amounts of video data that are difficult to review for surgeons wishing to evaluate and improve their skills. Therefore, a need exists for the development of computer-based analysis of laparoscopic video to accelerate surgical training and assessment. We developed a surgical instrument detection system for video recordings of laparoscopic gastrectomy procedures. This system, the use of which might increase the efficiency of the video reviewing process, is based on the open source neural network platform, YOLOv3. STUDY DESIGN: A total of 10,716 images extracted from 52 laparoscopic gastrectomy videos were included in the training and validation data sets. We performed 200,000 iterations of training. Video recordings of 10 laparoscopic gastrectomies, independent of the training and validation data set, were analyzed by our system, and heat maps visualizing trends of surgical instrument usage were drawn. Three skilled surgeons evaluated whether each heat map represented the features of the corresponding operation. RESULTS: After training, the testing data set precision and sensitivity (recall) was 0.87 and 0.83, respectively. The heat maps perfectly represented the devices used during each operation. Without reviewing the video recordings, the surgeons accurately recognized the type of anastomosis, time taken to initiate duodenal and gastric dissection, and whether any irregular procedure was performed, from the heat maps (correct answer rates ≥ 90%). CONCLUSIONS: A new automated system to detect manipulation of surgical instruments in video recordings of laparoscopic gastrectomies based on the open source neural network platform, YOLOv3, was developed and validated successfully.May 2020, Journal of the American College of Surgeons, 230(5) (5), 725 - 732, English, International magazine[Refereed]Scientific journal
- In the original article, there are errors in Fig. 1. Following is the corrected figure.Apr. 2020, Annals of surgical oncology, English, International magazine[Refereed]
- OBJECTIVE: Laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS) has been developed to prevent duodenal leakage by reinforcing the endoscopic submucosal dissection site. However, there has been no prospective trial showing the feasibility of D-LECS. Herein, we conducted a single-arm confirmatory trial to evaluate the safety of D-LECS for non-ampullary superficial duodenal neoplasms. METHODS: This prospective single-center single-arm confirmatory trial analyzed patients with non-ampullary superficial duodenal neoplasms who underwent D-LECS. The primary endpoint was the incidence of any postoperative leakage occurring on the duodenal wall within 1 month postoperatively. The planned sample size was 20 patients, considering a threshold of 28% and one-sided alpha value of 5%. RESULTS: Between January 2015 and September 2018, 20 eligible patients were enrolled. Sixteen tumors were located in the second portion, three in the first portion, and one in the third portion of the duodenal region. The median operative time was 225 (134-361) min and the median blood loss was 0 (0-150) mL. Curative resection (R0) with negative margins was achieved in 19 cases. One case of postoperative leakage and one case of bleeding of grade 2 according to the Clavien-Dindo classification were observed in this series. The median duration of postoperative hospital stay was 9 (5-12) days. No local recurrence was observed in any patient during the median follow-up of 15.0 (12.0-38.0) months. CONCLUSIONS: This trial confirmed the safety and feasibility of D-LECS for non-ampullary superficial duodenal neoplasms with respect to the low incidence of postoperative duodenal leakage.Apr. 2020, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, English, International magazine[Refereed]Scientific journal
- BackgroundAlthough the incidence and mortality have decreased, gastric cancer (GC) is still a public health issue globally. An international study reported higher survival in Korea and Japan than other countries, including the US. We examined the determinant factors of the high survival in Japan, compared with the US.MethodsWe analysed data on 78,648 cases from the nationwide GC registration project, the Japanese Gastric Cancer Association (JGCA), from 2004-2007 and compared them with 16,722 cases from the Surveillance, Epidemiology, and End Results Program (SEER), a US population-based cancer registry data from 2004-2010. We estimated five-year relative survival and applied a multivariate excess hazard model to compare the two countries, considering the effect of number of lymph nodes (LNs) examined.ResultsFive-year relative survival in Japan was 81.0%, compared with 45.0% in the US. After controlling for confounding factors, we still observed significantly higher survival in Japan. Among N2 patients, a higher number of LNs examined showed better survival in both countries. Among N3 patients, the relationship between number of LNs examined and differences in survival between the two countries disappeared.ConclusionAlthough the wide differences in GC survival between Japan and US can be largely explained by differences in the stage at diagnosis, the number of LNs examined may also help to explain the gaps between two countries, which is related to stage migration.Apr. 2020, Journal of epidemiology, 31(4) (4), 241 - 248, English, Domestic magazine, Co-authored internationally[Refereed]Scientific journal
- (株)メディカ出版, Apr. 2020, 消化器ナーシング, 25(4) (4), 305 - 311, Japanese[Refereed]Scientific journal
- Bone marrow-derived mesenchymal stem or stromal cells (MSC) have been shown to be recruited to various types of tumor tissues, where they interact with tumor cells to promote their proliferation, survival, invasion and metastasis, depending on the type of the tumor. We have previously shown that Ror2 receptor tyrosine kinase and its ligand, Wnt5a, are expressed in MSC, and Wnt5a-Ror2 signaling in MSC induces expression of CXCL16, which, in turn, promotes proliferation of co-cultured MKN45 gastric cancer cells via the CXCL16-CXCR6 axis. However, it remains unclear how CXCL16 regulates proliferation of MKN45 cells. Here, we show that knockdown of CXCL16 in MSC by siRNA suppresses not only proliferation but also migration of co-cultured MKN45 cells. We also show that MSC-derived CXCL16 or recombinant CXCL16 upregulates expression of Ror1 through activation of STAT3 in MKN45 cells, leading to promotion of proliferation and migration of MKN45 cells in vitro. Furthermore, co-injection of MSC with MKN45 cells in nude mice promoted tumor formation in a manner dependent on expression of Ror1 in MKN45 cells, and anti-CXCL16 neutralizing antibody suppressed tumor formation of MKN45 cells co-injected with MSC. These results suggest that CXCL16 produced through Ror2-mediated signaling in MSC within the tumor microenvironment acts on MKN45 cells in a paracrine manner to activate the CXCR6-STAT3 pathway, which, in turn, induces expression of Ror1 in MKN45 cells, thereby promoting tumor progression.Apr. 2020, Cancer science, 111(4) (4), 1254 - 1265, English, International magazine[Refereed]Scientific journal
- BACKGROUND/AIM: To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. PATIENTS AND METHODS: Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 2015 were included. Short-term and long-term outcomes were compared between the groups. A 1:2 propensity score matching was performed to compare long-term outcomes. RESULTS: All the dialysis patients underwent laparoscopic surgery. There were no significant differences in operative outcomes and postoperative short-term outcomes between the two groups. In the whole cohort, overall survival of dialysis patients was shorter than that in the non-dialysis ones (p=0.020), while disease-free survival did not differ between the two groups. After matching, there was no significant difference between the groups in overall or disease-free survival. CONCLUSION: Laparoscopic colorectal cancer surgery for dialysis patients seems safe and feasible and associates with comparable short-term outcome and recurrence rate to non-dialysis patients.Apr. 2020, Anticancer research, 40(4) (4), 2165 - 2170, English, International magazine[Refereed]Scientific journal
- Apr. 2020, JGH open : an open access journal of gastroenterology and hepatology, 4(2) (2), 309 - 311, English, International magazine[Refereed]Scientific journal
- OBJECTIVE: To investigate the frequency of laparoscopic liver resection (LLR) nationwide in Japan. BACKGROUND: LLR was initially limited to basic liver resection, but is becoming more common in advanced liver resection. METHODS: Retrospective observational study of 148,507 patients registered in the National Clinical Database 2011-2017. Excluded: liver resection with biliary and vascular reconstruction. RESULTS: LLR or open liver resection (OLR) was performed in 1848 (9.9%) and 16,888 (90.1%) patients, respectively, in 2011, whereas in 2017, LLR had increased to 24.8% and OLR decreased to 75.2% of resections (5648 and 17,099 patients, respectively). There was an annual increasing trend of LLR, starting at 9.9%, then 13.8%, 17.3%, 21.2%, 18.1%, 21.0%, and finally 24.8% in 2017. Basic LLR became more common, up to 30.8% of LR in 2017. Advanced LLR increased from 3.3% of all resections in 2011 to 10.8% in 2017. Throughout the years observed, there were fewer complications in LLR than OLR. Operative mortality was 3.6% for both advanced LLR and OLR in 2011, and decreased to 1.0% and 2.0%, respectively, in 2017. Mortality for both basic LLR and basic OLR were low and did not change throughout the study, at 0.5% and 1.6%, respectively, in 2011 and 0.5% and 1.1%, in 2017. CONCLUSIONS: LLR has rapidly become widespread in Japan. Basic LLR is now a standard option, and advanced LLR, while not as common yet, has been increasing year by year. LLR has been safely developed with low mortality and complications rate relative to OLR.Mar. 2020, Annals of surgery, English, International magazine[Refereed]Scientific journal
- 金原出版(株), Mar. 2020, 手術, 74(4) (4), 510 - 514, Japanese[Refereed]Scientific journal
- BACKGROUND: This study aimed to define an objective evidence-based threshold of high-volume hospitals (HVHs) for pancreatoduodenectomy (PD) using nationwide data systems. METHODS: A total of 36,453 patients underwent PD in 1,499 hospitals from 2012 to 2015 were collected from the National Clinical Database in Japan. Restricted cubic spline model with risk adjustment was used for definition of an objective evidence-based threshold of HVHs. RESULTS: The restricted cubic spline curve of 30-day and in-hospital mortality showed a continuous decrease with an increase in hospital volume and plateau phase of mortality was detected between approximately 30 and 50 PDs/year. On the basis of this curve, we defined hospitals ≥30 PDs/year as HVHs and ≤29 PDs/year as non-HVHs. We also sub-classified hospitals <5, 5-29, 30-49, and ≥50 PDs/year as low-volume, intermediate-volume, high-volume, and very high-volume hospitals using the spline curve. The odds ratio (OR) of risk-adjusted mortality decreased as hospital volume increased, with an OR of 0.34 for HVHs and 0.26 for very HVHs compared with low-volume hospitals. CONCLUSIONS: We consider that this concept is applicable to other high-risk procedures for reducing mortality after these procedures, which could improve medical care and health services.Mar. 2020, Journal of hepato-biliary-pancreatic sciences, 27(3) (3), 107 - 113, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.Mar. 2020, Annals of surgical oncology, 27(3) (3), 683 - 690, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Laparoscopic lateral pelvic lymph node dissection (LLND) has been reported to be feasible; however, studies comparing the outcomes of laparoscopic LLND with that of open LLND following preoperative chemoradiotherapy (CRT) are limited. METHODS: Between November 2005 and October 2017, 38 patients with locally advanced rectal cancer underwent total mesorectal excision and LLND following preoperative CRT at Kobe University Hospital. The data of the patients who underwent open LLND (OP group, n = 19) and laparoscopic LLND (LAP group, n = 19) were retrospectively collected and compared. RESULTS: The operative time was significantly longer in the LAP group compared with that in the OP group. However, the volume of blood loss was significantly higher, and transfusion was more frequently performed in the OP group than in the LAP group. The number of LLNs harvested in the LAP group was significantly higher than that in the OP group. The prevalence of perineal wound infection and bowel obstruction was significantly higher in the OP group than in the LAP group. However, no significant differences were observed between the groups in terms of 5-year overall survival, relapse-free survival, and local recurrence-free survival. CONCLUSIONS: Laparoscopic LLND is feasible and safe for patients with rectal cancer who were treated with preoperative CRT. Compared with open LLND, laparoscopic LLND might have several advantages such as higher yields of dissected LLNs and lower incidences of perineal wound infection and bowel obstruction.Mar. 2020, Surgical endoscopy, 34(3) (3), 1425 - 1431, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The proportion of elderly patients undergoing surgery for gastric cancer is increasing. However, limited number of therapeutic outcomes in the elderly has been reported. Here we examined the surgical results based on a nationwide survey of elderly patients who underwent surgery for Stage I gastric cancer. METHODS: Data from 68,353 Stage I patients who underwent gastrectomy between 2001 and 2007 were retrospectively collected. The accumulated data were reviewed and analyzed by the Japanese Gastric Cancer Association registration committee. We first classified the patients as those aged ≤ 74 years and ≥ 75 years. We further classified those patients aged ≥ 75 years into groups by 5-year increments to examine their short- and long-term postoperative outcomes. RESULTS: Patients aged ≥ 75 years accounted for 46.5%. The 30-day mortality rate was < 0.7% for any age group, but for those aged ≥ 75 years, the 60-day and 90-day mortality rates were 0.9-2.3% and 1.2-5.1%, respectively. An examination of long-term survival indicated that, as the class of age increased, the 5-year overall survival (OS) was 47.0-93.1% and disease-specific survival (DSS) was 91.4-98.2%, respectively. Although high DSS rates of ≥ 90% were found for all age groups, OS only accounted for ≤ 82% of patients aged ≥ 75 years. CONCLUSION: Among elderly patients with Stage I gastric cancer, deaths due to other diseases were frequently observed in the long term. Thus, for elderly patients, it may be appropriate to reconsider the treatment strategy with respect to the balance between the invasiveness of the treatment and the prognosis.Mar. 2020, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23(2) (2), 328 - 338, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Laparoscopic gastrectomy (LG) is an established minimally invasive procedure for gastric cancer. However, it is controversial whether LG is useful for patients with poor physical status classified into higher classes of the American Society of Anesthesiologists physical status (ASA-PS) classification. The aim of this study was to determine the feasibility of LG in patients with ASA-PS class ≥ 3. METHODS: We extracted data for a total of 28,160 patients with an ASA-PS class ≥ 3 who underwent distal or total gastrectomy for gastric cancer between January 2013 and December 2017 from the National Clinical Database Japan society for gastroenterological surgery registry. We developed a propensity score model from baseline demographics and comorbidities and matched patients undergoing LG to those undergoing open gastrectomy (OG) using a 1:1 ratio. Mortality and morbidities (within 30 days and in-hospital) were compared between the 6998 matched patient pairs. RESULTS: In-hospital mortality was significantly lower in patients undergoing LG than in those undergoing OG (2.3% vs. 3.0%, p = 0.01), while the 30-day mortality was similar (1.6% vs. 1.5%). The length of hospital stay was significantly shorter in the LG group (median, 14 days vs. 17 days, p < 0.001). The LG group had a significantly lower incidence of postoperative complications in patients with any grade complication (20.3% vs. 22.5%, p = 0.002) as well as those with ≥ grade 3 complications (8.7% vs. 9.8%, p = 0.03). CONCLUSION: LG was associated with decreased in-hospital mortality and a lower incidence of several postoperative complications when compared to OG among patients with poor physical condition.Mar. 2020, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 23(2) (2), 310 - 318, English, Domestic magazine[Refereed]Scientific journal
- Lead, 株式会社杏林社, Feb. 2020, 消化器外科専門医の心得, 上, 91 - 93, Japanese第1章消化器外科総論 10.保険診療とビックデータ 22)National Clinical Database[Refereed]Scientific journal
- Aging is a grave problem in sepsis, and T cell exhaustion is the main cause of sepsis-induced immunosuppression. Sepsis- and aging-induced T cell exhaustion is related to secondary infection with a poor long-term outcome in the elderly. However, the trend, impact, and mechanism of T cell exhaustion are still unclear. Interleukin (IL)-15 improves survival rate of septic mice via its antiapoptotic effect on T cells; however, it is still unclear how IL-15 reverses prolonged T cell exhaustion in aged septic mice. The purpose of this study was to clarify the trend of sepsis-induced T cell exhaustion and whether IL-15 prevents aging-induced persistent T cell exhaustion in septic mice. Preserved cecal slurry was injected intraperitoneally into young (6-week-old) and aged mice (18-24-month-old) 4 times, to induce clinically relevant repeated sepsis. IL-15 (1.5 μg) or phosphate-buffered saline was injected subcutaneously 3 times, body weight was serially measured, and peripheral blood cells from their cheek were serially collected for 50 days. Sepsis-induced T cell exhaustion was significantly severe in aged mice than in young mice and was accompanied with decreased naive CD4 and CD8 T cells (P < 0.01) and increased expression of program death 1 on T cell (P < 0.01) and regulatory T cell population (P < 0.01). IL-15 significantly improved sepsis-induced T exhaustion, with significantly increased numbers of natural killer cells and macrophages, and significantly enhanced phagocytosis activity in aged septic mice (P < 0.05). It decreased the long-term mortality associated with sepsis survivors by improving T cell exhaustion over an extended duration and also ameliorated aging-induced persistent T cell exhaustion in septic mice.Feb. 2020, Shock (Augusta, Ga.), 53(2) (2), 228 - 235, English, International magazine[Refereed]Scientific journal
- Esophagectomy for esophageal cancer is a highly invasive procedure, and a feeding jejunostomy tube (FJT) is routinely placed to ensure adequate enteral nutrition. However, the effect of perioperative short-term FJT placement remains controversial, and the aim of this study was to assess risks and benefits of routine FJT placement during esophagectomy and to determine parameters that can identify patients needing long-term FJT. This retrospective study included 393 patients who had undergone esophagectomy with gastric tube reconstruction via the posterior mediastinal route at the Kobe University Hospital and the Hyogo Cancer Center between April 2010 and December 2017. Propensity score matching was used to identify matched patients (139 per group) in the FJT and no-FJT groups. The incidence of postoperative complications and weight loss (3 months post-procedure) was compared in the matched cohort and significant risk factors predicting the need for long-term FJT placement in the whole cohort were identified. In the matched cohort, while weight loss was not different between the FJT and no-FJT groups (11% vs. 10%), the incidence of small bowel obstruction in the FJT group (11.5%) was significantly higher than that in the no-FJT group (0%). Multivariate analysis revealed that age (≥75 years), preoperative therapy, anastomosis leakage, and pulmonary complications were independent risk factors for long-term FJT placement. Routine placement of an FJT during esophagectomy increases small bowel obstruction and does not result in better nutritional status, suggesting that selective long-term FJT placement in high-risk patients should be considered.Jan. 2020, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 33(1) (1), English, International magazine[Refereed]Scientific journal
- Objectives: Dissection of the No. 11p lymph nodes is technically challenging because of variations in anatomical landmarks. This study aimed to determine the accuracy and efficacy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography simulation. Methods: Laparoscopic gastrectomy with No. 11p lymph node dissection with preoperative simulation using three-dimensional computed tomography was performed in 24 patients at our institution from October 2016 to May 2018. Initially, preoperative three-dimensional computed tomography findings with operative videos in these 24 patients were compared. The dorsal landmark was defined as an anatomical structure behind the splenic artery on preoperative three-dimensional computed tomography and operative videos. The dorsal landmark of No. 11p lymph node was divided into four types: (1) splenic vein type, (2) splenic vein and pancreas type, (3) pancreas type, and (4) unclear type. Then, to investigate the efficacy of three-dimensional computed tomography, we compared the clinical and pathological features and surgical outcomes of nine patients who underwent preoperative three-dimensional computed tomography simulation (three-dimensional computed tomography group) and 23 patients who did not undergo three-dimensional computed tomography simulation from August 2014 to September 2016 (non-three-dimensional computed tomography group). All procedures were performed by one surgeon certified by the Endoscopic Surgical Skill Qualification System in Japan. Results: The concordance rate between three-dimensional computed tomography and operative videos of the dorsal landmark using three-dimensional computed tomography was 79% (19/24). The operative time of No. 11p lymph node dissection was significantly shorter in the three-dimensional computed tomography group than in the non-three-dimensional computed tomography group (7.7 versus 15.8 min, P = 0.044). Conclusion: The accuracy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography was extremely high. Preoperative simulation with three-dimensional computed tomography was useful in shortening the operative time of No. 11p lymph node dissection.2020, SAGE open medicine, 8, 2050312120936918 - 2050312120936918, English, International magazine[Refereed]Scientific journal
- BACKGROUND: In 2009, the Japan Esophageal Society (JES) established a system for certification of qualified surgeons as "Board Certified Esophageal Surgeons" (BCESs) or institutes as "Authorized Institutes for Board Certified Esophageal Surgeons" (AIBCESs). We examined the short-term outcomes after esophagectomy, taking into consideration the certifications statuses of the institutes and surgeons. METHODS: This study investigated patients who underwent esophagectomy for thoracic esophageal cancer and who were registered in the Japanese National Clinical Database (NCD) between 2015 and 2017. Using hierarchical multivariable logistic regression analysis adjusted for patient-level risk factors, we determined whether the institute's or surgeon's certification status had greater influence on surgery-related mortality or postoperative complications. RESULTS: Enrolled were 16,752 patients operated on at 854 institutes by 1879 surgeons. There were significant differences in the backgrounds and incidences of postoperative complications and surgery-related mortality rates between the 11,162 patients treated at AIBCESs and the 5590 treated at Non-AIBCESs (surgery-related mortality rates: 1.6% vs 2.8%). There were also differences between the 6854 patients operated on by a BCES and the 9898 treated by a Non-BCES (1.7% vs 2.2%). Hierarchical logistic regression analysis revealed that surgery-related mortality was significantly lower among patients treated at AIBCESs. The institute's certification had greater influence on short-term surgical outcomes than the operating surgeon's certification. CONCLUSIONS: The certification system for surgeons and institutes established by the JES appears to be appropriate, as indicated by the improved surgery-related mortality rate. It also appears that the JES certification system contributes to a more appropriate medical delivery system for thoracic esophageal cancer in Japan.Jan. 2020, Esophagus : official journal of the Japan Esophageal Society, 17(1) (1), 41 - 49, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal cancer. Currently, transthoracic and abdominal esophagectomy with cervical anastomosis (McKeown esophagectomy) is a frequently used technique in Japan. However, cervical anastomosis is still an invasive procedure with a high incidence of anastomotic leakage. The use of a drainage tube to treat anastomotic leakage is effective, but the routine placement of a closed suction drain around the anastomosis at the end of the operation remains controversial. The objective of this study is to evaluate the postoperative anastomotic leakage rate, duration to oral intake, hospital stay, and analgesic use with nonplacement of a cervical drainage tube as an alternative to placement of a cervical drainage tube. METHODS: This is an investigator-initiated, investigator-driven, open-label, randomized controlled parallel-group, noninferiority trial. All adult patients (aged ≥20 and ≤85 years) with histologically proven, surgically resectable (cT1-3 N0-3 M0) squamous cell carcinoma, adenosquamous cell carcinoma, or basaloid squamous cell carcinoma of the intrathoracic esophagus, and European Clinical Oncology Group performance status 0, 1, or 2 are assessed for eligibility. Patients (n = 110) with resectable esophageal cancer who provide informed consent in the outpatient clinic are randomized to either nonplacement of a cervical drainage tube (n = 55) or placement of a cervical drainage tube (n = 55). The primary outcome is the percentage of Clavien-Dindo grade 2 or higher anastomotic leakage. DISCUSSION: This is the first randomized controlled trial comparing nonplacement versus placement of a cervical drainage tube during McKeown esophagectomy with regards to the usefulness of a drain for anastomotic leakage. If our hypothesis is correct, nonplacement of a cervical drainage tube will be recommended because it is associated with a similar anastomotic leakage rate but less pain than placement of a cervical drainage tube. TRIAL REGISTRATION: UMIN-CTR, 000031244. Registered on 1 May 2018.Dec. 2019, Trials, 20(1) (1), 758 - 758, English, International magazine[Refereed]Scientific journal
- Dec. 2019, 癌と化学療法, 46(13) (13), 2327 - 2329, Japanese虫垂腺癌術後に吻合部再発と診断された神経内分泌癌の1例(原著論文)[Refereed]Scientific journal
- Dec. 2019, Annals of surgical oncology, 26(Suppl 3) (Suppl 3), 817 - 817, English, International magazine[Refereed]
- Dec. 2019, Annals of surgical oncology, 26(Suppl 3) (Suppl 3), 814 - 814, English, International magazine[Refereed]
- AIM: Total lymphocyte count in preoperative peripheral blood is associated with prognosis in various cancers. The predictive value of preoperative total lymphocyte count for survival was assessed in older gastric cancer patients after gastrectomy. METHODS: A total of 200 gastric cancer patients aged ≥75 years who underwent curative resection from 2000 to 2014 were included in this retrospective study. The cut-off value of total lymphocyte count in preoperative peripheral blood was determined using receiver operating characteristic curve analysis, and the association with prognosis was examined. RESULTS: The cut-off value of total lymphocyte count was 1462/μL, and 94 patients were classified as low total lymphocyte count patients and 106 patients were classified as high total lymphocyte count patients. In univariate analysis, American Society of Anesthesiologists score ≥3, Charlson Comorbidity Index ≥3, total lymphocyte count <1462/μL, stage III, open approach, total gastrectomy, splenectomy and infectious complication were significantly associated with overall survival. In multivariate analysis, total lymphocyte count <1462/μL (P = 0.003), American Society of Anesthesiologists score ≥3 (P = 0.01) and stage III (P = 0.017) were independent prognostic factors. Low total lymphocyte count significantly reduced overall survival in stage I (P = 0.037) and II (P = 0.009) patients, but not stage III patients (P = 0.29). CONCLUSION: Total lymphocyte count in preoperative peripheral blood can predict postoperative survival of older patients with relatively early-stage gastric cancer. Geriatr Gerontol Int 2019; 19: 1215-1219.Dec. 2019, Geriatrics & gerontology international, 19(12) (12), 1215 - 1219, English, Domestic magazine[Refereed]Scientific journal
- Nov. 2019, 日本外科学会雑誌, 120(6) (6), 652 - 656, Japanese外科医とがん登録-NCDから見えてきたわが国のがん治療の実態- 5.胃がん登録[Refereed]Scientific journal
- PURPOSE: Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal squamous cell carcinoma (ESCC). Thoracic duct (TD) resection has been recommended as part of extended lymphadenectomy, although its merits are unclear. The aim of this two-institutional, matched-cohort study is to clarify whether TD resection improves prognosis in esophagectomy for ESCC. PATIENTS AND METHODS: In this two-institutional, matched-cohort study of 399 patients with ESCC who underwent McKeown esophagectomy between 2010 and 2014, the primary outcomes were overall survival (OS), disease-free survival (DFS), and cause-specific survival (CSS). Secondary outcomes were perioperative results and recurrence patterns. RESULTS: Based on a propensity score, 122 TD-resected or 122 TD-preserved patients in all stages were selected (median follow-up 4.5 years). The 5-year OS, DFS, and CSS rates in the TD-resected versus TD-preserved groups were 49% versus 60%, 53% versus 57%, and 58% versus 70%, respectively, without any significant differences. Operative time for the thoracic procedure was significantly longer and the number of retrieved mediastinal nodes was significantly higher in the TD-resected group (P = 0.009 and 0.005, respectively). The rates of chylothorax and left recurrent laryngeal nerve (RLN) palsy were significantly higher in the TD-resected group (P = 0.041 and 0.018, respectively). There were no significant differences in rates of local or distant metastases between the two groups. CONCLUSIONS: TD resection does not contribute to improve OS, DFS, or CSS in ESCC but increases incidence of chylothorax and left RLN palsy. Prophylactic TD resection should be avoided in esophagectomy for ESCC.Nov. 2019, Annals of surgical oncology, 26(12) (12), 4053 - 4061, English, International magazine[Refereed]Scientific journal
- miRNAs are key players in the integrated regulation of cellular processes and shape many of the functional properties that define the "cancer stem cell" (CSC) phenotype. Little is known, however, about miRNAs that regulate such properties in human colorectal carcinoma. In this study, we compared the expression levels of 754 miRNAs between paired samples of EpCAM+/CD44+ cancer cells (enriched in CSCs) and EpCAM+/CD44neg cancer cells (with CSC depletion) sorted in parallel from human primary colorectal carcinomas and identified miR-221 as the miRNA that displayed the highest level of preferential expression in EpCAM+/CD44+ cancer cells. High levels of miR-221 expression were associated with Lgr5+ cells in mouse colon crypts and reduced survival in patients with colorectal carcinoma. Constitutive overexpression of miR-221 enhanced organoid-forming capacity of both conventional colorectal carcinoma cell lines and patient-derived xenografts (PDX) in vitro. Importantly, constitutive downregulation of miR-221 suppressed organoid-forming capacity in vitro and substantially reduced the tumorigenic capacity of CSC populations from PDX lines in vivo. Finally, the most abundant splicing isoform of the human Quaking (QKI) gene, QKI-5, was identified as a functional target of miR-221; overexpression of miR-221-reduced QKI-5 protein levels in human colorectal carcinoma cells. As expected, overexpression of QKI-5 suppressed organoid-forming capacity in vitro and tumorigenic capacity of colorectal carcinoma PDX cells in vivo. Our study reveals a mechanistic link between miR-221 and QKI and highlights their key role in regulating CSC properties in human colorectal cancer. SIGNIFICANCE: These findings uncover molecular mechanisms underlying the maintenance of cancer stem cell properties in colon cancer.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/79/20/5151/F1.large.jpg.Oct. 2019, Cancer research, 79(20) (20), 5151 - 5158, English, International magazine[Refereed]Scientific journal
- Oct. 2019, 臨床外科, 74(10) (10), 1164 - 1168, Japanese完全腹腔鏡下手術における切離ラインの決定[Refereed]Scientific journal
- BACKGROUND/AIM: To clarify the usefulness of intraoperative colonoscopy (CS) for preventing postoperative anastomotic leakage and bleeding in rectal cancer surgery. PATIENTS AND METHODS: The data of rectal cancer patients who underwent circular-stapled anastomosis from January 2008 to December 2016 were compared between 162 patients who received intraoperative CS (the CS group) and 23 patients who did not receive intraoperative CS (the non-CS group). RESULTS: Anastomotic leakage rate in the CS group (8.6%) was similar to that in the non-CS group (4.3%) (p=0.70). Postoperative anastomotic bleeding rate was also similar between the CS and non-CS groups (2.4% vs. 0%, p=0.50). Although a positive air leak test was observed in two patients in the CS group, no postoperative leakage developed by adding intraoperative treatment. CONCLUSION: Although intraoperative CS did not significantly reduce the incidence of postoperative anastomotic leakage or bleeding, it can be useful for certain cases.Oct. 2019, Anticancer research, 39(10) (10), 5761 - 5765, English, International magazine[Refereed]
- BACKGROUND/AIM: To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS: Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2016. Seven patients underwent ILND after NACRT for clinically-positive ILN metastasis (ILND (+) group), while the remaining 36 did not receive ILND for clinically negative ILN metastasis (ILND (-) group). Their outcomes were retrospectively analyzed. RESULTS: Only one patient in the ILND (+) group had a local recurrence at six years after surgery. The 5-year recurrence-free survival was 100% and 65.4% in the ILND (+) and ILND (-) groups, respectively (p=0.09), and the 5-year overall survival was 100% and 83.2%, respectively (p=0.32). CONCLUSION: ILND following NACRT seems effective for rectal cancer patients with ILN metastasis.Oct. 2019, Anticancer research, 39(10) (10), 5767 - 5772, English, International magazine[Refereed]
- INTRODUCTION: Anatomical evaluation of the splenic flexure vein is essential for complete mesocolic excision with central vascular ligation when treating patients with splenic flexure cancer. Although there have been several studies relating to the arterial branches of the splenic flexure, very limited data are available regarding the variation in venous anatomy in this region. METHODS: Sixty-six patients with colorectal cancer who underwent preoperative 3-D CT between April 2016 and April 2017 were included in this retrospective study. The pattern of the venous drainage of the splenic flexure and its association with the inferior border of the pancreas were evaluated. RESULTS: The inferior mesenteric vein flowed into the splenic vein in 32 patients (48.5%), into the superior mesenteric vein in 27 patients (40.9%), and into the confluence of splenic vein and superior mesenteric vein in 7 patients (10.6%). The splenic flexure vein joined the inferior mesenteric vein in 62 patients (93.9%), the splenic vein in 2 patients (3.0%), and the middle colic vein in 2 patients (3.0%). The splenic flexure vein flowed into the inferior mesenteric vein below the level of the inferior border of the pancreas in 58 patients (90.6%) and above it in 4 patients (6.3%). CONCLUSION: Preoperative evaluation of the venous pattern of the splenic flexure on 3-D CT is useful before complete mesocolic excision with central vascular ligation to avoid intraoperative bleeding during splenic flexure cancer surgery.Oct. 2019, Asian journal of endoscopic surgery, 12(4) (4), 412 - 416, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Although a self-expanding metallic stent (SEMS) or a transnasal or transanal decompression tube is sometimes used as a bridge to surgery in patients with obstructive colorectal cancer, the optimal decompression procedure to achieve successful laparoscopic surgery remains unclear. METHODS: Forty-two patients with obstructive colorectal cancer who were preoperatively decompressed by using SEMS (the SEMS group, n = 20) or a decompression tube (the DT group, n = 22) between January 2010 and February 2017 were included in this retrospective study. RESULTS: In the SEMS group, 20 patients (100%) were able to eat and 17 patients (85%) were able to undergo total colonoscopy preoperatively, but no patients could do so in the DT group (P < 0.01 and P < 0.01, respectively). The serum albumin level increased in the time between admission and just before surgery in five patients in the SEMS groups (25%), whereas it decreased in all patients in the DT group (P = 0.037). Laparoscopic surgery was performed more frequently in the SEMS groups (19 patients, 95%) than in the DT group (13 patients, 59.1%) (P = 0.018). Primary anastomosis without stoma was also achieved more frequently in the SEMS groups (19 patients, 95%) than in the DT group (15 patients, 68.2%) (P = 0.047). Anastomotic leakage did not occur in the SEMS group, but it did occur in one patient in the DT group. The recurrence-free survival rate did not differ between the groups (median follow-up period: 21 months). CONCLUSION: In patients with obstructive colorectal cancer, SEMS appears to be more effective than a decompression tube as a preoperative treatment to achieve successful laparoscopic resection without stoma.Oct. 2019, Asian journal of endoscopic surgery, 12(4) (4), 401 - 407, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Several studies have suggested that thoracoscopic esophagectomy (TE) in the prone position (TEP) may be more feasible than TE in the lateral position (TEL); however, few studies have compared long-term survival between the two procedures. We evaluated whether TEP is oncologically equivalent to TEL. METHODS: Surgical outcomes of TEs performed from January 2006 to December 2013 at our hospital were retrospectively analyzed. Propensity score matching was used to control for confounding factors. RESULTS: TE was performed in 200 patients diagnosed with esophageal squamous cell carcinoma; 78 patients were matched in two procedures. The mean thoracic operative time in TEL was shorter than in TEP (228.9 min vs. 299.1 min; p < 0.001); however, the mean thoracic blood loss in TEL was higher than in TEP (186.9 ml vs. 76.5 ml; p < 0.001). The mean number of thoracic lymph nodes harvested in TEL was lower than in TEP (23.5 vs. 26.9; p < 0.05), and the pulmonary complication rate in TEL was higher than in TEP (30.8% vs. 15.4%; p < 0.05). The 5-year overall survival rates in pathological stage I (81.2% vs. 81.6%; p = 0.82), stage II (65.3% vs. 80.9%; p = 0.21), stage III (26.7% vs. 24.2%; p = 0.86) and all stages (63.6% vs. 62.3%; p = 0.88), and the 5-year progression-free survival rates in pathological stage I (78.0% vs. 81.8%; p = 0.54), stage II (53.5% vs. 77.6%; p = 0.13), stage III (10.5% vs. 12.8%; p = 0.81) and all stages (53.6% vs. 57.9%; p = 0.50) were not significantly different between the two procedures. CONCLUSION: TEP and TEL provide equal oncological efficiency.Oct. 2019, Annals of surgical oncology, 26(11) (11), 3736 - 3744, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Sarcopenia or degenerative loss of skeletal muscle mass is related to poor prognosis in patients with cancer. This study aimed to clarify the clinical significance of skeletal muscle loss (SML) during chemotherapy for metastatic colorectal cancer (mCRC). METHODS: A total of 249 patients who were secondarily registered in a pooled database of mCRC patients with the first-line systemic chemotherapy and prospectively enrolled in six clinical trials of Kyushu Study Group of Clinical Cancer were included in this study. Skeletal muscle area was calculated from computed tomography images before and 3 and 6 months after treatment. Baseline sarcopenia and SML (cut-off value = 9%) were evaluated. RESULTS: Baseline sarcopenia was observed in 135 of 219 patients who were evaluated before treatment. They tended to be male; older; and have lower body mass index, lower visceral and subcutaneous fat contents, and a lower waist circumference (P < 0.01); however, baseline sarcopenia was not associated with prognosis. SML at 3 months was associated with an incidence of adverse events (P = 0.01), poor objective response rate (ORR) (P < 0.01), and poor progression-free survival (PFS) (P = 0.03), and it was an independent predictive factor for poor ORR (P < 0.01) and PFS (P = 0.04). CONCLUSION: SML at 3 months after systemic chemotherapy for mCRC was associated with poor treatment response. Thus, clarifying the importance of SML prevention guarantees a more effective chemotherapy.Oct. 2019, International journal of clinical oncology, 24(10) (10), 1204 - 1213, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: It remains unknown how much institutional medical structure and process of implementation of clinical practice guidelines for esophageal cancers can improve quality of surgical outcome in Japan. METHODS: A web-based questionnaire survey was performed for departments registered in the National Clinical Database in Japan from October 2014 to January 2015. Quality indicators (QIs) including structure and process indicators (clinical practice guideline adherence) were evaluated on the risk-adjusted odds ratio for operative mortality (AOR) of the patients using registered cases in the database who underwent esophagectomy and reconstruction in 2013 and 2014. RESULTS: Among 916 departments which registered at least one esophagectomy case during the study period, 454 departments (49.6%) responded to the questionnaire. Analyses of 6661 cases revealed that two structure QIs (certification of training hospitals by Japan Esophageal Society and presence of board-certified esophageal surgeons) were associated with significantly lower AOR (p < 0.001 and p = 0.005, respectively). One highly recommended process QI regarding preoperative chemotherapy had strong tendency to associate with lower AOR (p = 0.053). In two process QIs, the answer "performed at the doctor's discretion" showed a significant negative impact on prognosis, suggesting importance of institutional uniformity. CONCLUSIONS: The medical institutional structure of board-certified training sites for esophageal surgeons and of participation of board-certified esophageal surgeons improves surgical outcome in Japan. Establishment of appropriate QIs and their uniform implementation would be crucial for future quality improvement of medical care in esophagectomy.Oct. 2019, Esophagus : official journal of the Japan Esophageal Society, 16(4) (4), 362 - 370, English, Domestic magazine[Refereed]Scientific journal
- PURPOSE: Completion gastrectomy (CG) is a common procedure for remnant gastric cancer (RGC). However, partial gastrectomy for gastric cancer has several benefits compared to total gastrectomy in terms of the quality of life. In this study, we evaluated the feasibility and advantage of subtotal resection of the remnant stomach (SR) for clinical stage IA RGC. METHODS: A total of 43 patients who underwent gastrectomy for clinical stage IA RGC were included. CG and SR were performed on 27 (62.8%) and 16 patients (37.2%), respectively. The short- and long-term outcomes, including the nutritional status, after CG and SR for clinical stage IA RGC were compared between the two groups. RESULTS: There were no significant differences in pathological stage or incidence of postoperative complications between the two groups. The decrease in body weight, body mass index, and serum albumin level was significantly lower in the SR group than in the CG group (P < 0.001, P = 0.025, and 0.008). In the SR group, there was no recurrence at the remaining lymph nodes or gastric stump. The 5-year overall survival rate was 87.8% in the CG group and 86.1% in the SR group, without a significant difference between the two groups (P = 0.959). CONCLUSIONS: The present study showed the noninferiority of SR to CG based on surgical and oncological outcomes for clinical stage IA RGC. Furthermore, SR has an advantage over CG in terms of postoperative nutritional status. Therefore, SR could be an alternative elective treatment option for early RGC located around the anastomotic site.Sep. 2019, Langenbeck's archives of surgery, 404(6) (6), 753 - 760, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Esophagectomy with three-field lymph node dissection is common, but the effects of cervical lymph node dissection on overall survival in patients with thoracic esophageal cancer remain controversial. Recently, we performed thoracoscopic esophagectomy and superior mediastinum and paracervical esophageal lymph nodes could have been effectively dissected from the thoracic cavity. This study assessed the risks and benefits of prophylactic supraclavicular lymph node dissection in patients who underwent thoracoscopic esophagectomy. METHODS: This retrospective study included 294 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital and Hyogo Cancer Center between April 2010 and December 2015. Patients in the two-field (paracervical esophageal lymph nodes were dissected from the thoracic cavity) and three-field lymph node dissection groups were matched using propensity score matching. We compared overall survival and the incidence of postoperative complications in the matched cohort and assessed the estimated efficacy of additional lymphadenectomy for supraclavicular lymph node recurrence in the entire cohort. RESULTS: In the matched cohort, overall survival was not significantly different between the two groups, but the incidence of recurrent laryngeal nerve palsy was significantly higher in the 3FL group than in the 2FL group. In the entire cohort, 162 patients underwent a two-field lymph node dissection; 11 experienced supraclavicular nodal recurrence. We performed additional supraclavicular lymph node dissection in three patients without systemic metastasis, all of whom are alive without any other recurrence. CONCLUSIONS: Prophylactic cervical lymph nodes dissection in thoracoscopic esophagectomy does not improve long-term survival but does increase the risk of postoperative complications.Sep. 2019, Annals of surgical oncology, 26(9) (9), 2899 - 2904, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The current status of site-specific cancer registry has not been elucidated, but sufficient system is found in some societies. The purpose of this study was to clear the present condition of site-specific cancer registries in Japan and to suggest for the improvement. METHODS: The questionnaire was conducted by the study group of the Ministry of Health, Labor, and Welfare. It consisted of 38 questions, conflicts of interest, clinical research method, informed consent and funding for registry. We distributed this questionnaire to 28 academic societies, which had published the clinical practice guideline(s) assessed under Medical Information Network Distribution Service (MINDS). RESULTS: The concept of the importance in assessment for medical quality by the data of the site-specific cancer registry was in good consensus. But the number of the society with the mature registry was limited. The whole-year registry with the scientific researches in the National Clinical Database (NCD) and in the Translational Research Informatics Center (TRI) might seem to be in success, because assured enhancement may be estimated. Now, academic societies have the structural factors, i.e., the financial limitation in the registry maintenance and the data analysis, and in the difficulty of employment of the researchers with skill and talent. CONCLUSIONS: To manage the site-specific cancer registry effectively, the scientific registry system will be essentially important. Each academic society had much experienced highly qualified clinical researches in past. Accordingly, the scientific suggestion and co-operation should be of great importance for the improvement.Sep. 2019, International journal of clinical oncology, 24(9) (9), 1161 - 1168, English, Domestic magazine[Refereed]Scientific journal
- Aug. 2019, 日本ヘルニア学会誌, 5(2) (2), 3 - 9, JapaneseNational Clinical Databaseにおける鼠径部ヘルニア手術 Annual Report 2011-2017[Refereed]Scientific journal
- BACKGROUND/AIM: The aim of this study was to investigate PD-L1 expression and its association with prognosis in esophageal squamous cell carcinoma (ESCC) before and after neoadjuvant chemotherapy (5-fluorouracil and cisplatin, NAC-FP). PATIENTS AND METHODS: Using a database of 69 ESCC patients, we analyzed PD-L1 expression on tumor cells (TCs) and immune cells (ICs), as well as the density of CD8+ tumor-infiltrating lymphocytes (TILs) in pretreatment biopsy specimens-versus-surgical specimens after resection. We determined the prognostic significance of these factors. RESULTS: The fraction of ESCC containing ICs expressing PD-L1 and having a high CD8+ TIL density was significantly increased after neoadjuvant treatment. However, PD-L1 expression on TCs or ICs, and CD8+ TIL density, was not significantly associated with patient survival in ESCC patients. CONCLUSION: NAC-FP induced PD-L1 expression on ICs and CD8+ TILs in ESCC patients. This finding suggests that PD-1/PD-L1 blockade could be combined with NAC-FP to treat ESCC patients.Aug. 2019, Anticancer research, 39(8) (8), 4539 - 4548, English, International magazine[Refereed]Scientific journal
- BACKGROUND: The aim of the present study was to clarify the association between preoperative liver function and complications after hepatectomy. METHODS: The study included 11,686 patients registered in the National Clinical Database for 2015 for whom data on indocyanine green at 15 min (ICG15) and hepatectomy were available. The patients were divided into four groups: group A (ICG15 <10%; n = 5,661), group B (ICG15 10% to <20%; n = 4,381), group C (ICG15 20% to <30%; n = 1,173) and group D (ICG15 >30%; n = 463). Hepatectomy procedures were classified as partial resection (n = 3,934), systematic subsegmentectomy (n = 2,055), monosectionectomy (n = 2,043), bisectionectomy (n = 2,993) and trisectionectomy (n = 208). Complications were classified using the Clavien-Dindo classification (CD) and evaluated by ICG15 category and procedure type. RESULTS: Complications more severe than CD III increased significantly as the operation time lengthened and the intraoperative bleeding volume increased (P < 0.001). ICG15 category was positively associated with operative death, >CD III complications, surgical site infection (SSI), liver failure, and intractable ascites for many of the major hepatectomy procedures, but not with bile leakage. More complications were observed in patients outside the Makuuchi criteria than in those within the criteria. CONCLUSIONS: Operation time and intraoperative bleeding volume are significantly associated with severe postoperative complications in patients undergoing hepatectomy. ICG15 is a good indicator predictive of operative death, >CD III complications, SSI, liver failure and intractable ascites.Aug. 2019, Journal of hepato-biliary-pancreatic sciences, 26(8) (8), 331 - 340, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Laparoscopic complete mesocolic excision (CME) for hepatic or splenic flexural colon cancer is considered technically demanding. The double (hepatic and splenic) flexural colon cancers are rare, and the laparoscopic CME procedure for such disease is not standardized. METHODS: This video presents laparoscopic CME for double (hepatic and splenic) flexural colon cancers using a medial and cranial approach. RESULTS: The patient was a 60-year-old woman with the diagnosis of splenic flexure cancer (cT4N1M0) and hepatic flexure cancer (cT3N0M0). Laparoscopic subtotal colectomy was performed. First, the left colic artery was divided at its origin, and the inferior mesenteric vein also was divided at the same level. The descending mesocolon was widely separated from the retroperitoneal tissues using a medial approach. Then, lymph node dissection along the surgical trunk was performed using a cranial approach. Finally, the transverse mesocolon was divided at the inferior border of the pancreas, and CME was achieved. The specimen was extracted through a small incision at the umbilicus, and side-to-side ileo-sigmoid anastomosis was performed extracorporeally. CONCLUSIONS: The approach presented in the video might be useful for standardization of laparoscopic CME for double flexural colon cancers.Aug. 2019, Annals of surgical oncology, 26(8) (8), 2516 - 2516, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Laparoscopic gastrectomy (LG) might have greater clinical benefits for elderly patients as less invasive surgery; however, there is still little evidence to support its benefit. We evaluated the surgical outcomes of elderly patients in a nationwide prospective cohort study. METHODS: One hundred and sixty-nine participating institutions were identified by stratified random sampling, and were adjusted for hospital volume, type and location. During 1 year from 2014 to 2015, consecutive patients who underwent gastrectomy for gastric cancer were prospectively enrolled. 'Elderly' was defined as ≥ 75 years of age, based on the prevalence of comorbidities and the activities of daily living of patients of this age. We compared the surgical outcomes of LG to those of open gastrectomy (OG) in non-elderly and elderly patients. The primary outcome was the incidence of severe morbidities (Grade ≥ 3). RESULTS: Eight thousand nine hundred and twenty-seven patients were enrolled [non-elderly, n = 6090 (OG, n = 2602; LG, n = 3488); elderly, n = 2837 (OG, n = 1471; LG, n = 1366)]. Grade ≥ 3 complications occurred in 161 (10.9%) patients who underwent OG and 98 (7.2%) who underwent LG (p < 0.001). After adjusting for confounding factors, we confirmed that laparoscopic surgery was not an independent risk factor (odds ratio = 0.81, 0.60-1.09). OG was associated with a significantly longer median length of postoperative stay in comparison to LG (16 versus 12 days, p < 0.001). There were no significant differences in the incidence of other postoperative comorbidities. CONCLUSION: The safety of LG in elderly patients was demonstrated. LG shortened the length of postoperative hospital stay.Jul. 2019, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 22(4) (4), 845 - 852, English, Domestic magazine[Refereed]Scientific journal
- [Practical Use of National Clinical Database in Cancer Treatment].The National Clinical Database(NCD)started its registration in 2011 as the parent body ofthe database system linked to the board-certification system. Risk models of mortality or morbidity for 9 procedures in gastroenterological surgery have been established, and feedback reports to participants have been implemented. The NCD can provide data on each facility's severity-adjusted clinical performance, which can be compared with national or prefectural data. The NCD's huge stock of data also provides important information about operations on such topics as association between the participation of boardcertified surgeons and operative mortality, or the impact of hospital volume on risk-adjusted mortality. Breast cancer registry or pancreas cancer registry had been implemented into NCD in 2012, and several cancer registries have been implemented. With high level ofcompleteness ofthe registration, addition oflong term prognosis ofthe patients with cancer to NCD will improve cancer treatment nationwide.Jul. 2019, Gan to kagaku ryoho. Cancer & chemotherapy, 46(7) (7), 1087 - 1092, Japanese, Domestic magazine[Refereed]Scientific journal
- PURPOSE: The surgical indication of laparoscopic surgery for pT4 colon cancer remains to be established because only a few studies have investigated the short- and long-term outcomes of laparoscopic surgery for them to date. Therefore, we aimed to elucidate the validity of laparoscopic surgery for them. METHODS: We retrospectively analyzed 81 patients with pT4 colon cancer who underwent surgical resection with a curative intent at Kobe University Hospital from January 2007 to December 2015. The short- and long-term outcomes were compared between the propensity score-matched patients who underwent laparoscopic colectomy (LAP group, n = 25) and those who underwent open colectomy (OP group, n = 25). RESULTS: Intraoperative blood loss was significantly less in the LAP group than in the OP group (p = 0.029). Operative time, R0 resection rate, and morbidity did not significantly differ between the two groups. The 5-year overall survival (OS) and the 5-year recurrence-free survival (RFS) did not significantly differ between the propensity score-matched groups. Univariate and multivariate analyses of the entire cohort showed the surgical approach (LAP vs OP) selected was not a significant prognostic factor for OS or RFS. CONCLUSIONS: The short and the long-term outcomes were similar between the LAP and OP groups. Laparoscopic surgery might be a safe and feasible option for pT4 colon cancer patients.Jul. 2019, International journal of colorectal disease, 34(7) (7), 1259 - 1265, English, International magazine[Refereed]Scientific journal
- The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Among 362 cases with a successful dual-color in situ hybridization analysis, 19 (5%) and 13 (4%) had MDM2 amplification and chromosome 12 polysomy, respectively, and these were examined as an MDM2-positive group. A comparison between amplified and polysomic cases revealed that the latter were more strongly associated with preoperative chemotherapy than the former. Sixteen (50%) of 32 MDM2-positive cases had positive results in all tissue cores examined, indicating diffuse MDM2 alterations. Cases with the diffuse alteration of MDM2 were characterized by an advanced pT stage and extensive vascular infiltration. The relationship between MDM2 copy number increases and p53 mutations was weak, with the overexpression of p53 being similarly detected in MDM2-positive and MDM2-negative cases (59% versus 49%; P = .267). Overall survival was shorter in patients with MDM2-positive ESCC than in those without MDM2 alterations (P = .033). The poor prognostic value of MDM2 alterations became more obvious when only diffusely altered cases were counted (P = .005). In conclusion, the present study revealed that MDM2 copy number increases occurred in 9% of ESCC cases, and MDM2 alterations, particularly diffuse abnormalities, were associated with a poor prognosis. MDM2-altered ESCC may achieve beneficial effects from MDM2-targeted therapy.Jul. 2019, Human pathology, 89(89) (89), 1 - 9, English, International magazine[Refereed]Scientific journal
- Background: The Japanese National Clinical Database (NCD) is a large-scale, nationwide, web-based data entry system that is linked to the surgical board certification system and covers almost all surgical cases carried out in Japan. Aim: To evaluate outcomes according to the gastroenterological section of the NCD. Methods: The 115 surgical procedures stipulated by the "Training Curriculum for Board-Certified Surgeons in Gastroenterology" were registered from 2011 to 2017. The number of surgeries, preoperative comorbidities, and short-term outcomes were compared between registration periods. Results: In total, 3 818 414 cases have been registered. More than 70% of all surgeries were carried out at certified institutions. The annual number of cases has been increasing year after year, and the aged population has also been increasing. Although the rates of preoperative comorbidities and postoperative complications have been increasing, the postoperative mortality rate has remained relatively low; in 2017, the 30-day mortality rate was 1.0% among those who underwent esophagectomy, 0.7% among those who underwent distal gastrectomy, 1.1% among those who underwent total gastrectomy, 1.3% among those who underwent right hemicolectomy, 0.5% among those who underwent low anterior resection, 1.3% among those who underwent hepatectomy, and 1.3% among those who underwent pancreaticoduodenectomy. The annual rate of endoscopic surgery dramatically increased over 7 years between 2011 and 2017, especially for low anterior resection (29.5%-62.6%) and esophagectomy (31.0%-56.1%). Conclusion: This database is expected to ensure the quality of the board-certification system and surgical outcomes in gastroenterological surgery.Jul. 2019, Annals of gastroenterological surgery, 3(4) (4), 426 - 450, English, Domestic magazine[Refereed]Scientific journal
- Mirror image is one of the most difficult situations that the assistant surgeon encounters in laparoscopic colorectal surgery. The aim of the present study was to investigate whether task performance with mirror images improves by changing the position of the monitor and the rotation angle of the camera. Twenty-four surgeons performed the task under different conditions: Coaxial image (C), Mirror image (M), Mirror image + Monitor on the left side of participants (M + Mon), Mirror image + Camera rotated 90 degrees to the right (M + Cam), and Mirror image + Monitor on the left side + Camera rotated to the right (M + Mon + Cam) in a training box. The outcome measure was the mean time for completing the task. The mean time for completing the task, in decreasing order, was M (111.4 ± 58.9 seconds) > M + Mon (70.5 ± 29.4 seconds) > M + Cam (47.1 ± 17.1 seconds) > M + Mon + Cam (33.4 ± 10.3 seconds) > C (20.5 ± 3.5 seconds). (multivariable analysis of variance (MANOVA), p = 7.9 × 10-7) Task performance with mirror images improved by changing the monitor positioning and camera rotation angle. This novel method is a simple way to overcome mirror image in laparoscopic colorectal surgery.Jun. 2019, Scientific reports, 9(1) (1), 8371 - 8371, English, International magazine[Refereed]Scientific journal
- Jun. 2019, 外科, 81(6月7号) (6月7号), 716 - 720, Japanese【消化管術後合併症-発症要因と対応】 胃術後食物停滞の発症要因,予防対策と対応[Refereed]Scientific journal
- Esophageal squamous cell carcinoma (ESCC) is a highly aggressive tumor with frequent recurrence even after curative resection. The tumor microenvironment, which consists of non-cancer cells, such as cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs), was recently reported to promote several cancers, including ESCC. However, the role of CAF as a coordinator for tumor progression in ESCC remains to be elucidated. In our immunohistochemical investigation of ESCC tissues, we observed that the intensity of expression of two CAF markers-alpha smooth muscle actin (αSMA) and fibroblast activation protein (FAP)-in the tumor stroma was significantly correlated with the depth of tumor invasion, lymph node metastasis, advanced pathological stage, and poor prognosis. We co-cultured human bone marrow-derived mesenchymal stem cells (MSCs) with ESCC cells and confirmed the induction of FAP expression in the co-cultured MSCs. These FAP-positive MSCs (which we defined as CAF-like cells) promoted the cell growth and migration of ESCC cells and peripheral blood mononuclear cell-derived macrophage-like cells. CAF-like cells induced the M2 polarization of macrophage-like cells. A cytokine array and ELISA revealed that CAF-like cells secreted significantly more CCL2, Interleukin-6, and CXCL8 than MSCs. These cytokines promoted the migration of tumor cells and macrophage-like cells. The silencing of FAP in CAF-like cells attenuated cytokine secretion. We compared cell signaling of MSCs, CAF-like cells, and FAP-silenced CAF-like cells; PTEN/Akt and MEK/Erk signaling were upregulated and their downstream targets, NF-κB and β-catenin, were also activated with FAP expression. Silencing of FAP attenuated these effects. Cytokine secretion from CAF-like cells were attenuated by inhibitors against these signaling pathways. These findings indicate that the collaboration of CAFs with tumor cells and macrophages plays a pivotal role in tumor progression, and that FAP expression is responsible for the tumor promotive and immunosuppressive phenotypes of CAFs.Jun. 2019, Laboratory investigation; a journal of technical methods and pathology, 99(6) (6), 777 - 792, English, International magazine[Refereed]Doctoral thesis
- Lead, Jun. 2019, 週間 日本医事新報, 4963(6月2号) (6月2号), 46 - 47, Japanese胃癌補助化学療法の現状と展望[Refereed]Scientific journal
- BACKGROUND: To perform a safe and precise laparoscopic surgery for the splenic flexure cancer, it is important for surgeons to gain a preoperative understanding of the running of the feeding artery of the splenic flexure. We evaluated the blood supply to the splenic flexure by using preoperative three-dimensional computed tomography (3D-CT). METHOD: We retrospectively analyzed a total of 88 patients with colorectal cancer who underwent preoperative 3D-CT at our institutions between April 2016 and June 2017. RESULTS: The arterial blood supply to the splenic flexure was divided into four patterns as follows: type 1, the left branch of the middle colic artery (MCA) with common trunk and the left colic artery (LCA) (n = 48, 54.5%); type 2, the left branch of the MCA with independent origin and the LCA (n = 8, 9.1%); type3, the accessory-MCA (A-MCA) and the LCA (n = 27, 30.7%); and type4, the LCA alone (n = 5, 5.7%). The MCA had the common trunk of the right and left branches in the majority of cases (85.2%). The right and left branches of the MCA arose separately from the superior mesenteric artery (SMA) in 8 of 88 patients (9.1%). CONCLUSIONS: The arterial patterns of the splenic flexure were classified into four patterns by using preoperative 3D-CT. The A-MCA existed in 30% of the patients in this study. These information should be helpful to perform the optimal surgery for the splenic flexure cancer.Jun. 2019, International journal of colorectal disease, 34(6) (6), 1047 - 1051, English, International magazine[Refereed]Scientific journal
- PURPOSE: S-1 is a standard postoperative adjuvant chemotherapy for patients with stage II or III gastric cancer in Asia. Neoadjuvant or perioperative strategies dominate in Western countries, and docetaxel has recently shown significant survival benefits when combined with other standard regimens in advanced cancer and perioperative settings. PATIENTS AND METHODS: This randomized phase III study was designed to prove the superiority of postoperative S-1 plus docetaxel over S-1 alone for R0 resection of pathologic stage III gastric cancer. The sample size of 1,100 patients was necessary to detect a 7% increase in 3-year relapse-free survival as the primary end point (hazard ratio, 0.78; 2-sided α = .05; β = .2). RESULTS: The second interim analysis was conducted when the number of events reached 216 among 915 enrolled patients (median follow-up, 12.5 months). Analysis demonstrated the superiority of S-1 plus docetaxel (66%) to S-1 (50%) for 3-year relapse-free survival (hazard ratio, 0.632; 99.99% CI, 0.400 to 0.998; stratified log-rank test, P < .001), and enrollment was terminated as recommended by the independent data and safety monitoring committee. Incidences of grade 3 or greater adverse events, particularly neutropenia and leukopenia, were higher in the S-1 plus docetaxel group, but all events were manageable. CONCLUSION: Addition of docetaxel to S-1 is effective with few safety concerns in patients with stage III gastric cancer. The present findings may also be applicable in countries in which perioperative adjuvant chemotherapy or chemoradiation is not standard.May 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 37(15) (15), 1296 - 1304, English, International magazine[Refereed]Scientific journal
- May 2019, 手術, 73(6) (6), 837 - 848, Japanese特集 食道癌手術の最前線─合併症ゼロを目指した私の秘訣 腹臥位アプローチによる胸腔鏡下食道癌根治術─上縦隔郭清手技を中心に[Refereed]Scientific journal
- PURPOSE: In esophageal squamous cell carcinoma (ESCC), lymph nodes (LNs) around the subcarina and main bronchi are thought to be highly involved. Therefore, complete dissection of these LNs with preservation of the pulmonary branches of the vagus nerves, which control important pulmonary functions, is recommended. The aim of this retrospective study was to investigate the feasibility of reliable method for lymphadenectomy around the subcarina and main bronchi, named the medial approach, during thoracoscopic esophagectomy in the prone position (TEP). METHODS: This was a case-matched control study of patients who underwent TEP for ESCC. The fundamental concept in this method is to first exfoliate the LNs around the subcarina and main bronchi from the pericardium. Developing the operative field contributes to visualizing and preserving the pulmonary branches of the right vagus nerve. Twenty-three patients who underwent the medial approach and 23 patients who underwent the conventional approach were selected by the use of propensity score matching to compare the operative outcomes. RESULTS: The medial approach significantly reduced operative time for procedure (16 ± 3 vs 30 ± 6 min, p < 0.0001) and operative blood loss (123 ± 108 vs 207 ± 162 ml, p = 0.046) comparing with conventional approach. The incidence of postoperative pneumonia was lower in the medial approach group (4%) than in the conventional approach group (15%) (p = 0.069). CONCLUSIONS: The medial approach for lymphadenectomy around the subcarina and both main bronchi during TEP is technically safe and feasible in shorting the operative time with possibility to reduce postoperative pneumonia.May 2019, Langenbeck's archives of surgery, 404(3) (3), 359 - 367, English, International magazine[Refereed]Scientific journal
- Apr. 2019, 癌の臨床, 64(4) (4), 257 - 264, Japanese高齢者胃癌の外科治療[Refereed]Scientific journal
- PURPOSES: To evaluate the reliability of data collected from the gastroenterological section of the National Clinical Database of Japan (NCD), which began registrations in 2011 with ten surgical subspecialty societies. METHODS: During 2014 and 2015, 1,136,700 cases involving 115 procedures at 4374 hospitals were registered in the gastroenterological surgery section of the NCD. After a test audit using the 2014 data, 17 hospitals were selected for the first audit and data verification for 2015. The data accuracy of patient demographics, surgical outcomes, and processes was assessed using 45 items from the cases registered, in comparison with the medical records. RESULTS: In the first audit of the 2015 data, case registration accuracy verification involved 338 patients (99.4% of the extracted cases). The data accuracy with the maximum postoperative variables was > 95%. Accuracy of the mortality and status 30 days after the surgery was high (> 99%) with a sensitivity of 1.00 and a specificity of 1.00. Among the six complications studied, the recorded cases had high specificity but lower sensitivity (0.70-0.89). CONCLUSIONS: We verified the data from the gastroenterological section of the NCD and found high accuracy of data entry.Apr. 2019, Surgery today, 49(4) (4), 328 - 333, English, Domestic magazine[Refereed]
- Collective invasion is an important strategy of cancers of epithelial origin, including colorectal cancer (CRC), to infiltrate efficiently into local tissues as collective cell groups. Within the groups, cells at the invasive front, called leader cells, are highly polarized and motile, thereby providing the migratory traction that guides the follower cells. However, its underlying mechanisms remain unclear. We have previously shown that signaling emanating from the receptor tyrosine kinase Ror2 can promote invasion of human osteosarcoma cells and that intraflagellar transport 20 (IFT20) mediates its signaling to regulate Golgi structure and transport. Herein, we investigated the role of Ror2 and IFT20 in collective invasion of CRC cells, where Ror2 expression is either silenced or nonsilenced. We show by cell biological analyses that IFT20 promotes collective invasion of CRC cells, irrespective of expression and function of Ror2. Intraflagellar transport 20 is required for organization of Golgi-associated, stabilized microtubules, oriented toward the direction of invasion in leader cells. Our results also indicate that IFT20 promotes reorientation of the Golgi apparatus toward the front side of leader cells. Live cell imaging of the microtubule plus-end binding protein EB1 revealed that IFT20 is required for continuous polarized microtubule growth in leader cells. These results indicate that IFT20 plays an important role in collective invasion of CRC cells by regulating organization of Golgi-associated, stabilized microtubules and Golgi polarity in leader cells.Apr. 2019, Cancer science, 110(4) (4), 1306 - 1316, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Preoperative nutritional status is considered to affect the short-term and long-term outcomes of cancer patients. The clinical value of the controlling nutritional status (CONUT) score in elderly patients undergoing gastrectomy for gastric cancer remains unknown. METHODS: This study reviewed 211 elderly patients aged 75 years or over who underwent curative resection for gastric cancer from 2000 to 2015. Patients were grouped according to the preoperative CONUT score into those with normal nutrition (75 patients), light malnutrition (100 patients) and moderate or severe malnutrition (36 patients). The predictive value of the CONUT score for postoperative morbidity and survival was assessed. RESULTS: Impaired nutrition was associated with cardiovascular disease (P = 0.012) and chronic kidney disease (P = 0.014), and worsened malnutrition was linked to advanced age (P = 0.004), decreased body mass index (P = 0.008) and advanced disease stage (P = 0.01). Multivariate analysis showed the CONUT score as an independent predictor of procedure-unrelated infectious morbidity (odds ratio, 2.36; 95% confidence interval [CI], 0.99-5.40; P = 0.046). Patients with a higher CONUT score had significantly shorter overall survival in both stage I and stage II/III gastric cancer (P = 0.044 and P = 0.007, respectively) and reduced cancer-specific survival in stage II/III (P = 0.003) The CONUT score was a strong predictors of overall survival (hazard ratio [HR], 2.12; 95% CI, 1.18-3.69; P = 0.012) and cancer-specific survival (HR, 3.75; 95% CI, 1.30-10.43; P = 0.015) independent of disease stage. CONCLUSIONS: The preoperative CONUT score is a simple and promising predictor of postoperative procedure-unrelated infectious morbidity and prognosis in elderly gastric cancer patients.Apr. 2019, World journal of surgery, 43(4) (4), 1076 - 1084, English, International magazine[Refereed]Scientific journal
- BACKGROUND: Single-incision laparoscopic surgery (SILS) has recently been used for the management of gastrointestinal stromal tumors (GIST). Here, the feasibility and effectiveness of SILS for GIST and indications for SILS according to tumor location were investigated. CASE PRESENTATION: From July 2009 to May to 2013, a total of 14 patients underwent SILS for GIST. In 14 patients, 5 patients had tumor near the esophagogastric junction, 4 patients on the lesser curvature, 2 patients on the anterior wall, 2 patients on the posterior wall, and 1 patient on the greater curvature. The surgery of one patient with lesser curvature tumor was converted to conventional laparoscopic surgery because of technical difficulties. Another patient required re-operation because of a posterior wall tumor causing gastric obstruction. There was no complication in patients with tumors on the anterior wall and greater curvature. CONCLUSIONS: Because SILS for GISTs located mainly on the anterior wall was feasible, SILS may be considered the most appropriate type of laparoscopic surgery for GISTs in this location. However, for GISTs on the posterior wall or with lesser curvature, which require more complex management, SILS is challenging and should be carefully adapted.Mar. 2019, Surgical case reports, 5(1) (1), 50 - 50, English, International magazine[Refereed]Scientific journal
- Esophagectomy with extended lymphadenectomy remains the mainstay of treatment for localized esophageal cancer. However, it is one of the most invasive procedures with high morbidity. To reduce invasiveness, minimally invasive esophagectomy (MIE), which includes thoracoscopic, laparoscopic, mediastinoscopic, and robotic surgery, is becoming popular worldwide. Thoracoscopic esophagectomy in the prone position is ergonomic for the surgeon and has better perioperative arterial oxygen pressure/fraction of inspired oxygen (P/F) ratio. Thoracoscopic esophagectomy in the left decubitus position is easy to introduce because it is similar to standard right posterolateral open esophagectomy (OE) in position. It has a relatively short operative time. Laparoscopic approach could potentially have a substantial effect on pneumonia prevention under the condition of thoracotomy. Mediastinoscopic surgery has the potential to reduce pulmonary complications because it can avoid a transthoracic procedure. In robotic surgery, in the future, less recurrent laryngeal nerve palsy will be expected as a result of polyarticular fine maneuvering without human tremors. In studies comparing MIE with OE, mediastinoscopic surgery and robotic surgery are usually not included; these studies show that MIE has a longer operative time and less blood loss than OE. MIE is particularly beneficial in reducing postoperative respiratory complications such as atelectasis, despite no dramatic decrease in pneumonia. Reoperation might occur more frequently with MIE. There is no significant difference in mortality rate between MIE and OE. It is important to recognize that the advantages of MIE, particularly "less invasiveness", can be of benefit at facilities with experienced medical personnel.Mar. 2019, Annals of gastroenterological surgery, 3(2) (2), 138 - 145, English, Domestic magazine[Refereed]
- AIM: To evaluate the clinical significance of lateral pelvic lymph node (LLN) size in predicting pathological metastasis and prognosis in rectal cancer treated with preoperative chemoradiotherapy (CRT) followed by surgery. PATIENTS AND METHODS: Fifty-two patients with rectal cancer who underwent curative surgery after preoperative CRT were included. Fifteen patients underwent total mesorectal excision (TME) alone, while 37 patients underwent TME with LLN dissection for clinical LLN metastasis. RESULTS: Pathological metastasis was identified in seven (2.6%) out of 270 resected LLNs in six (16.2%) out of 37 patients. The cut-off value of the short-axis diameter was 7.0 mm before and 6.0 mm after CRT. The 5-year recurrence-free survival rate was significantly higher in patients with LLNs <7.0 mm than in those with LLNs ≥7.0 mm (85.7% versus 56.8%, p=0.038). CONCLUSION: Short-axis diameter of LLNs of 7.0 mm seems to be an optimal cut-off value before CRT for predicting pathological metastasis and prognosis.Feb. 2019, Anticancer research, 39(2) (2), 993 - 998, English, International magazine[Refereed]Scientific journal
- Aim: A comprehensive description of morbidity and mortality risk factors for post liver transplant has not been available to date. In this study, we established real-time risk models of postoperative morbidities and mortality in liver transplant recipients using two Japanese nationwide databases. Methods: Data from two Japanese nationwide databases were combined and used for this study. We developed real-time prognostic models for morbidity and mortality from a derivation cohort (n = 1472) and validated the findings with an independent cohort (n = 395). Preoperative variables (C1), preoperative and intraoperative variables (C2), and all variables including postoperative morbidities within 30 days (C3) were analyzed to evaluate the independent risk factors for postoperative morbidity and mortality. Results: We established real-time risk models for morbidity and mortality. Areas under the curve (AUC) of C1 and C2 risk models for mortality were 0.74 (0.63-0.82) and 0.79 (0.69-0.86), respectively. Multivariate logistic analysis using C3 showed that hemoglobin <10 g/dL, operative time (hours), and five postoperative morbidities (prolonged ventilation >48 hours, coma >24 hours, renal dysfunction, postoperative systemic sepsis, and serum total bilirubin ≥10 mg/dL) represented independent risk factors for mortality (AUC = 0.87, 95% confidence interval [CI]: 0.78-0.93). Conclusions: Real-time risk models of postoperative morbidities and mortality at various perioperative time points in liver transplant recipients were established. These novel approaches may improve postoperative outcomes of liver transplant recipients. Furthermore, these real-time risk models may be applicable to other surgical procedures.Jan. 2019, Annals of gastroenterological surgery, 3(1) (1), 75 - 95, English, Domestic magazine[Refereed]Scientific journal
- BACKGROUND: Despite interest in surgeon and hospital volume effects on distal gastrectomy, clinical significance has not been confirmed in a large-scale population. We studied to clarify the effects of surgeon and hospital volume on postoperative mortality after distal gastrectomy for gastric cancer among Japanese patients in a nationwide web-based data entry system. METHODS: We extracted data on distal gastrectomy for gastric cancer from the National Clinical Database between 2011 and 2015. The primary outcome was operative mortality. Hospital volume was divided into 3 tertiles: low (1-22 cases per year), medium (23-51) and high (52-404). Surgeon volume was divided into the 5 groups: 0-3, 4-10, 11-20, 21-50, 51 + cases per year. We calculated the 95% confidence interval (CI) for the mortality rate based on odds ratios (ORs) estimated from a hierarchical logistic regression model. RESULTS: We analyzed 145,523 patients at 2182 institutions. Operative mortality was 1.9% in low-, 1.0% in medium- and 0.5% in high-volume hospitals. The operative mortality rate decreased definitively with surgeon volume, 1.6% in the 0-3 group and 0.3% in the 51 + group. After risk adjustment for surgeon and hospital volume and patient characteristics, hospital volume was significantly associated with operative morality (medium: OR 0.64, 95% CI 0.56-0.73, P < 0.001; high: OR 0.42, 95% CI 0.35-0.51, P < 0.001). CONCLUSIONS: We demonstrate that hospital volume can have a crucial impact on postoperative mortality after distal gastrectomy compared with surgeon volume in a nationwide population study. These findings suggest that centralization may improve outcomes after distal gastrectomy.Jan. 2019, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 22(1) (1), 190 - 201, English, Domestic magazine[Refereed]
- BACKGROUND: Although laparoscopic total gastrectomy (LTG) is considered a technically demanding procedure with safety issues, it has been performed in several hospitals in Japan. Data from a nationwide web-based data entry system for surgical procedures (NCD) that started enrollment in 2011 are now available for analysis. METHODS: A retrospective cohort study was conducted using data from 32,144 patients who underwent total gastrectomy and were registered in the NCD database between January 2012 and December 2013. Mortality and morbidities were compared between patients who received LTG and those who underwent open total gastrectomy (OTG) in the propensity score-matched Stage I cohort and Stage II-IV cohort. RESULTS: There was no significant difference in mortality rate between LTG and OTG in both cohorts. Operating time was significantly longer in LTG while the blood loss was smaller. In the Stage I cohort, LTG, performed in 33.6% of the patients, was associated with significantly shorter hospital stay but significantly higher incidence of readmission, reoperation, and anastomotic leakage (5.4% vs. 3.6%, p < 0.01). In the Stage II-IV cohort, LTG was performed in only 8.8% of the patients and was associated with significantly higher incidence of leakage (5.7% vs. 3.6%, p < 0.02) although the hospital stay was shorter (15 days vs. 17 days, p < 0.001). CONCLUSION: LTG was more discreetly introduced than distal gastrectomy, but remained a technically demanding procedure as of 2013. This procedure should be performed only among the well-trained and informed laparoscopic team.Jan. 2019, Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 22(1) (1), 202 - 213, English, Domestic magazine[Refereed]Scientific journal
- Neoadjuvant chemoradiotherapy (nCRT) has been widely used as a multidisciplinary approach for stage II/III rectal cancer. However, its safety and efficacy are controversial because previous studies have shown conflicting outcomes. The present review aimed to elucidate the benefits and limitations of nCRT for patients with rectal cancer. Future perspectives of nCRT are also described. No recent randomized trials have been able to show a survival benefit, although many studies have demonstrated good local control with the use of fluoropyrimidine (e.g. 5-fluorouracil [FU] or capecitabine)-based nCRT. Addition of oxaliplatin (OX) to FU-based nCRT might improve overall survival by preventing distant metastasis, as shown in recent meta-analyses. However, control of adverse effects is an important concern with this treatment. New treatment strategies such as nonoperative management (watch and wait policy) and total neoadjuvant therapy (TNT) are promising, but the establishment of reliable diagnostic methods of metastasis is essential. Development of new biomarkers is also necessary to select patients who are more likely to benefit from nCRT.Jan. 2019, Annals of gastroenterological surgery, 3(1) (1), 24 - 33, English, Domestic magazine[Refereed]Scientific journal
- Jan. 2019, 胃がんperspective, 10(2) (2), 5 - 13, Japanese高齢者胃癌に対する標準治療[Refereed]Scientific journal
- PURPOSE: The prognosis of esophageal cancer is dismal, and the 3-year overall survival of cStage III does not reach 50.0%. C-reactive protein (CRP) is a well-known protein that reflects the short- and long-term operative outcomes of esophageal cancer. However, since elevated CRP levels are often observed in cStage III esophageal cancer, whether or not CRP still reflects the prognosis is unclear. METHODS: Eighty-four patients who were diagnosed with cStage III esophageal cancer and underwent R0/1 operation from January 2007 to December 2014 were retrospectively evaluated. RESULTS: The mean age was 66.8 years, and the majority of patients were male. The median preoperative and postoperative CRP levels were 0.15 and 1.47 mg/dl, respectively. A majority of the patients underwent thoracoscopic surgery, and the median blood loss and operation duration were 456 ml and 11.6 h, respectively. Forty-six patients (54.8%) died during the observation period, and the 3-year overall survival was 52.4%. A multivariate analysis showed that the preoperative CRP level, postoperative albumin level, blood loss, and complications were independent prognostic factors. A multiple linear regression analysis showed that an elevated postoperative CRP level was affected by the operation duration and preoperative CRP levels. CONCLUSIONS: These findings suggest that the preoperative CRP level is a prognostic factor for cStage III esophageal cancer and that postoperative elevation in the CRP level is affected by the operation duration.Jan. 2019, Surgery today, 49(1) (1), 90 - 95, English, Domestic magazine[Refereed]Scientific journal
- Jan. 2019, 日本医師会雑誌, 147(10) (10), 1996 - 1996, Japanese【機能性消化管疾患診療の実際】 嚥下障害・つまり感があれば器質性疾患に注意(解説/特集)[Refereed]Scientific journal
- Jan. 2019, 標準外科学, 15(1) (1), 53 - 59, Japanese無菌法(消毒法および減菌法)[Refereed]Scientific journal
- Jan. 2019, 日本医師会雑誌, 147(10) (10), 1996 - 1996, Japanese嚥下障害・つまり感があれば器質性疾患に注意[Refereed]Scientific journal
- Jan. 2019, Surg Today., 49(1) (1), 90 - 95, EnglishInitial verification of data from a clinical database of gastroenterological surgery in Japan.[Refereed]Scientific journal
- Dec. 2018, Ann Thorac Surg, 106(6) (6), e309 - e311, EnglishMass-Forming Deep Pseudodiverticulosis of the Esophagus With 18F-Fluorodeoxyglucose Uptake[Refereed]Scientific journal
- Nov. 2018, Anticancer Res, 38(11) (11), 6139 - 6145, EnglishPROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer[Refereed]Scientific journal
- Oct. 2018, Surg Endosc, 32(10) (10), 4228 - 4234, EnglishThe effect on surgical skills of expert surgeons using 3D/HD and 2D/4K resolution monitors in laparoscopic phantom tasks[Refereed]Scientific journal
- Oct. 2018, ANN GASTROENTEROL SURG, 2(6) (6), 398 - 399, EnglishSurgery: To what extent can we operate[Refereed]Scientific journal
- Oct. 2018, World J Surg, 42(10) (10), 3398 - 3404, EnglishOptimal Surgery for Mid-Transverse Colon Cancer: Laparoscopic Extended Right Hemicolectomy Versus Laparoscopic Transverse Colectomy[Refereed]Scientific journal
- Oct. 2018, 日本臨床, 76(増刊8 食道癌) (増刊8 食道癌), 54 - 59, Japanese【食道癌(第2版)-基礎・臨床研究の進歩-】 食道癌の疫学 Big dataからみる食道癌 食道癌全国登録とNCD
- Sep. 2018, Anticancer Res, 38(9) (9), 5289 - 5294, EnglishSignificance of Additional Gastrectomy Including Endoscopic Submucosal Dissection Scar for Gastric Cancer[Refereed]Scientific journal
- PURPOSE: Endoscopic submucosal dissection (ESD) is widely used to treat esophageal cancer, but some patients require additional treatment due to the possibility of lymph node metastasis. The aim of this study was to elucidate the clinical outcomes of these additional treatments. METHODS: The study included 59 patients who developed superficial esophageal squamous cell carcinoma after noncurative ESD treated between 2005 and 2016, of whom 28 underwent esophagectomy and 31 received chemoradiotherapy (CRT). RESULTS: The median follow-up periods were 45 months in the esophagectomy group and 41 months in the CRT group. The overall survival did not differ significantly between the groups (P = 0.46). However, there were no recurrences in the esophagectomy group, and the disease-specific survival rate was significantly higher in this group (P = 0.042). Among the patients at high risk for recurrence due to massive tumor invasion (≥ SM2) with lymphovascular invasion (esophagectomy group, six patients; CRT group, ten patients), none in the esophagectomy group had recurrence, whereas four in the CRT group died of esophageal cancer (P = 0.031). CONCLUSION: The overall survival did not differ significantly between the groups. However, compared with CRT, esophagectomy provided more favorable disease control for patients with massive tumor invasion (≥ SM2) with lymphovascular invasion.Aug. 2018, Surgery today, 48(8) (8), 783 - 789, English, Domestic magazine[Refereed]Scientific journal
- Aug. 2018, ANN GASTROENTEROL SURG, 2(6) (6), 400 - 405, EnglishRecent updates in perioperative chemotherapy and recurrence pattern of gastric cancer[Refereed]Scientific journal
- Aug. 2018, Histopathology, 73(2) (2), 259 - 272, EnglishInterleukin-33 overexpression reflects less aggressive tumour features in large-duct type cholangiocarcinomas[Refereed]Scientific journal
- Aug. 2018, 癌の臨床, 64(2号) (2号), 83 - 89, Japanese【腹膜播種治療の今】 胃癌腹膜播種に対しての化学療法[Refereed]
- Jul. 2018, Anticancer Res, 38(7) (7), 4333 - 4338, EnglishImmunosuppression Induced by Perioperative Peritonitis Promotes Lung Metastasis[Refereed]Scientific journal
- Jul. 2018, Anticancer Res, 38(7) (7), 4233 - 4239, EnglishApplication of iNKT Cell-targeted Active Immunotherapy in Cancer Treatment[Refereed]Scientific journal
- Jun. 2018, Esophagus, EnglishStrategy for esophageal non-epithelial tumors based on a retrospective analysis of a single facility[Refereed]Scientific journal
- Jun. 2018, 日本気管食道科学会会報, 69(3号) (3号), 221 - 223, Japanese用語解説 有茎空腸再建術
- BACKGROUND AND OBJECTIVES: To explore whether lymphocytes in sentinel lymph nodes (SLNs) are highly exposed to tumor neoantigens and thus express high level of programmed death 1 (PD-1), we examined PD-1 expression in SLNs and non-sentinel regional lymph nodes (non-SLNs) in breast cancer. METHODS: We performed PD-1 immunohistochemistry in two cohorts: 40 metastasis-negative SLNs including 10 patients for each subtype (luminal A-like, luminal B-like, HER2, and triple negative breast cancer [TNBC]); and 25 pairs of metastasis-positive SLNs and non-SLNs (10 luminal A-like, 10 luminal B-like, and 5 TNBC). RESULTS: Among 40 metastasis-negative SLNs, 34 and 6 samples were PD-1 intensity grade 1 (low) and 2 (high), respectively. PD-1 intensity correlated with PD-1-positive lymphocyte numbers (P = 0.005); TNBC had the highest PD-1 lymphocyte numbers among all subtypes. The median PD-1-positive lymphocyte number was higher in SLNs than non-SLNs. In most cases, more lymphocytes in SLNs expressed PD-1 than those in non-SLNs (P < 0.0001). CONCLUSIONS: TNBC had the greatest PD-1 expression among all subtypes, and metastasis-positive SLNs had more PD-1-positive lymphocytes than downstream non-SLNs. These data suggested that lymphocytes in SLNs are activated following exposure to tumor neoantigens and thus tumor specific, and could be utilized as a biomarker platform.May 2018, Journal of surgical oncology, 117(6) (6), 1131 - 1136, English, International magazine[Refereed]Scientific journal
- 3D Culture Represents Apoptosis Induced by Trastuzumab Better than 2D Monolayer Culture.BACKGROUND: Our hypothesis was that three-dimensional (3D) culture better represents differential in vivo responses to trastuzumab between PIK3CA-wild-type (wt) and mutant (mt) cell lines than does two-dimensional (2D) culture. MATERIALS AND METHODS: Apoptosis and cell signaling proteins were evaluated in response to trastuzumab with and without BKM120, a pan-phosphatidylinositol 3-kinase (PI3K) inhibitor, using western blot analysis of four breast cancer cell lines with human epidermal growth factor receptor 2 (HER2) amplification. RESULTS: Increased expression of cleaved poly (ADP-ribose) polymerase (PARP) was observed only in 3D-cultured PIK3CA-wt lines in response to trastuzumab, but not in 2D-cultured PIK3CA-wt or PIK3CA-mt lines. Decrease in the ratio of phosphorylated (p-)AKT to AKT in response to trastuzumab was more profound in PIK3CA-wt cells than in PIK3CA-mt cells in 3D culture, while the difference between PIK3CA genotypes was less apparent in 2D culture. Treatment with BKM120 and trastuzumab resulted in a stronger increase in cleaved PARP than either treatment alone. CONCLUSION: 3D Culture appears to better represent trastuzumab-induced apoptosis and resistance to trastuzumab associated with PIK3CA mutation.May 2018, Anticancer research, 38(5) (5), 2831 - 2839, English, International magazine[Refereed]Scientific journal
- Apr. 2018, 癌と化学療法, 45(4号) (4号), 709 - 711, JapaneseTrastuzumab Capecitabine Cisplatin療法により治癒切除し得た胃癌腹膜転移の1例[Refereed]Scientific journal
- Apr. 2018, World J Surg, 42(4) (4), 1065 - 1072, EnglishThe Depth from the Skin to the Celiac Artery Measured Using Computed Tomography is a Simple Predictive Index for Longer Operation Time During Laparoscopic Distal Gastrectomy[Refereed]Scientific journal
- Apr. 2018, Int J Colorectal Dis, 33(4) (4), 367 - 374, EnglishOutcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancer[Refereed]Scientific journal
- Apr. 2018, Anticancer Res, 38(4) (4), 2363 - 2368, EnglishCurative Gastrectomy with Perioperative Chemotherapy Improves the Survival for Unresectable Gastric Cancer[Refereed]Scientific journal
- Mar. 2018, Langenbecks Arch Surg, EnglishStandardizing procedures improves and homogenizes short-term outcomes after minimally invasive esophagectomy[Refereed]Scientific journal
- Mar. 2018, 癌と化学療法, 45(3) (3), 471 - 473, JapaneseS-1/CDDP療法後に手術を施行し長期予後を得ている胃癌腹膜播種の1例[Refereed]Scientific journal
- Mar. 2018, Surg Endosc, 32(3) (3), 1202 - 1208, EnglishAnatomical and embryological perspectives in laparoscopic complete mesocoloic excision of splenic flexure cancers[Refereed]Scientific journal
- Feb. 2018, Surg Endosc, 32(2) (2), 582 - 588, EnglishThe learning effect of using stereoscopic vision in the early phase of laparoscopic surgical training for novices[Refereed]Scientific journal
- BACKGROUND: Although sarcopenia increases postoperative complications following esophagectomy, its effects on prognosis remain unclear. This study was performed to identify the effect of sarcopenia on 90-day unplanned readmission and overall survival (OS) after esophagectomy. METHODS: Ninety-eight patients with esophageal cancer who underwent esophagectomy were enrolled in this study. Unplanned readmission was defined as any emergent hospitalization within 90 days after discharge. Sarcopenia, defined as low muscle mass plus low muscle strength and/or low physical performance according to the Asian consensus definition, was assessed prior to esophagectomy. Multivariate logistic regression analysis was performed to identify factors that contributed to 90-day unplanned readmission. OS was estimated using the Kaplan-Meier method, and a Cox proportional hazards model was used to assess the relationship between sarcopenia and OS. RESULTS: Thirty-one patients (31.6%) were diagnosed with sarcopenia. The 90-day unplanned readmission rate was significantly higher in patients with sarcopenia than those without (42.9% vs. 16.4%, respectively; p = 0.01). Multivariable logistic regression analysis showed that sarcopenia was an independent predictor of 90-day unplanned readmission [odds ratio 3.71, 95% confidence interval (CI) 1.29-11.05; p = 0.02], and the log-rank test showed that sarcopenia was associated with OS (p = 0.01). Moreover, sarcopenia was a significant predictor of OS after adjustment for age, sex, and pathological stage (hazard ratio 2.35, 95% CI 1.21-4.54; p = 0.01). CONCLUSIONS: Sarcopenia is a risk factor for 90-day unplanned readmission and OS following esophagectomy. Assessment of sarcopenia could help to identify patients at higher risk of a poor prognosis after esophagectomy.Feb. 2018, Annals of surgical oncology, 25(2) (2), 456 - 464, English, International magazine[Refereed]Scientific journal
- Feb. 2018, ANN GASTROENTEROL SURG, 2(2) (2), 129 - 136, EnglishRecent updates in the surgical treatment of colorectal cancer[Refereed]
- BACKGROUND: Oxaliplatin + S-1 is a recognized treatment regimen in Japan, but there are no Japanese clinical data on an oxaliplatin dose of 130 mg/m2. The current research involves a single-arm, prospective, phase II clinical trial to examine the efficacy and safety of oxaliplatin + S-1 with an oxaliplatin dose of 130 mg/m2 to treat HER2-negative advanced/recurrent gastric cancer previously untreated with chemotherapy in Japan. METHODS/DESIGN: The primary endpoint of this trial will be the response rate, and the secondary endpoints will be the safety profile of oxaliplatin + S-1, progression-free survival, the response rate in subjects under the age of 75, overall survival, time to treatment failure, duration of treatment, time to failure of strategy, and dose intensity. The threshold response rate is 45% and the expected response rate is 60%. Assuming that a one-tailed score test will be performed with an α of 0.05, 68 patients are needed to ensure a statistical power of 80%. Planned enrollment is 70 subjects and the total duration of this trial is expected to be 3 years. DISCUSSION: Since replacing cisplatin with oxaliplatin should provide the same level of therapeutic efficacy while limiting adverse events and simplifying treatment, oxaliplatin + S-1 may be increasingly used to treat gastric cancer in Japan. Verifying the efficacy and safety of oxaliplatin + S-1 with an oxaliplatin dose of 130 mg is an important task that the current trial has set out to achieve. TRIAL REGISTRATION: The protocol was registered at the website of the University Hospital Medical Information Network (UMIN), Japan (protocol ID UMIN000017550) on May 29, 2015. The details are available at the following web address: http://www.umin.ac.jp/ctr/ .Jan. 2018, BMC cancer, 18(1) (1), 57 - 57, English, International magazine[Refereed]Scientific journal
- The National Clinical Database (NCD) of Japan started its registration in 2011 and over 9 000 000 cases from more than 5000 facilities were registered over a 6-year period. This is the report of NCD based upon gastrointestinal surgery information in excess of 3 200 000 cases from 2011 to 2016 adding data of complications. About 70% of all gastrointestinal surgeries were carried out at certified institutions, and the percentage of surgeries done at certified institutions was particularly high for the esophagus (92.4% in 2016), liver (88.4%), pancreas (89.8%), and spleen (86.8%). The percentage of anesthesiologist participation was more than 90% for almost all organs, except 85.7% for the rectum and anus. Approximately, more than two-thirds of the surgeries were carried out with the participation of a board-certified surgeon. Although patients have been getting older, mortalities have not been increasing. There were differences in the incidence of complications according to organ site and procedure. Remarkably, mortality rates of low anterior resection were very low, and those of hepatectomy and acute diffuse peritonitis surgery have been gradually decreasing. Although the complication rates were gradually increasing for esophagectomy or pancreaticoduodenectomy, the mortality rates for these procedures were decreasing. Nationwide, this database is expected to ensure the quality of the board-certification system and surgical outcomes in gastroenterological surgery.Jan. 2018, Annals of gastroenterological surgery, 2(1) (1), 37 - 54, English, Domestic magazine[Refereed]Scientific journal
- To clarify the safety profile of laparoscopic distal gastrectomy (LDG) for gastric cancer patients, the short-term outcome of LDG was compared to that of open distal gastrectomy (ODG) by propensity score matching using data from the Japanese National Clinical Database (NCD). We conducted a retrospective cohort study of patients undergoing distal gastrectomy between January 2012 and December 2013. Using the data for 70 346 patients registered in the NCD, incidences of mortality and morbidities were compared between LDG patients and ODG patients in the propensity score matched stage I patients (ODG: n = 14 386, LDG: n = 14 386) and stage II-IV patients (ODG: n = 3738, LDG: n = 3738), respectively. There was no significant difference in mortality rates between LDG and ODG at all stages. Operating time was significantly longer in LDG compared to ODG, whereas blood loss and incidences of superficial surgical site infection (SSI), deep SSI, and wound dehiscence were significantly higher in ODG at all stages. Interestingly, pancreatic fistula was found significantly more often in LDG (1%) compared to ODG (0.8%) (P = .01) in stage I patients; however, it was not different in stage II-IV patients. The length of postoperative stay was significantly longer in patients undergoing ODG compared to LDG at all stages. LDG in general practice might be a feasible therapeutic option in patients with both advanced gastric cancer and those with early gastric cancer in Japan.Jan. 2018, Annals of gastroenterological surgery, 2(1) (1), 55 - 64, English, Domestic magazine[Refereed]Scientific journal
- INTRODUCTION: Primary appendiceal cancer with fistula formation is extremely rare. We report a case of a patient with appendiceal cancer invading the ileum who underwent successful laparoscopic ileocecal resection. PRESENTATION OF CASE: A 76-year-old man who presented with fever and abdominal pain was diagnosed with acute appendicitis and received antibiotics at a local hospital. After a few days, he was referred to our hospital because of an abnormality found in the colonoscopy, which was an oozing ulcer in the terminal ileum. Laparoscopic ileocecal resection was performed with a preoperative diagnosis of ileal cancer. The tumor adhered to the right internal inguinal ring. We dissected the right spermatic cord involved in the tumor. The resected specimen revealed a fistula between the appendiceal orifice and ileac ulcer. Histopathological examination revealed a well differentiated tubular adenocarcinoma. We made the diagnosis of appendiceal cancer with an ileal fistula because the ileal ulcer was derived from the appendiceal site. DISCUSSION: Most cases of appendiceal cancer with a fistula undergo laparotomy, but in selected cases, laparoscopic resection should be considered a feasible, safe, and curative procedure. Our patient underwent laparoscopic ileocecal resection, whereby the tumor and other organs with invasion were resected successfully with a negative surgical margin. CONCLUSION: This is the first case report of appendiceal cancer with an ileal fistula successfully treated with laparoscopic resection. Laparoscopic ileocecal resection can be applied for appendiceal cancers with a fistula by experienced surgeons with careful consideration.2018, International journal of surgery case reports, 52, 120 - 124, English, International magazine[Refereed]Scientific journal
- Jan. 2018, J Thorac Cardiovasc Surg, 155(1) (1), 32 - 40, English[Refereed]Scientific journal
- Jan. 2018, Mod Pathol, 31(1) (1), 83 - 92, EnglishSOX2-silenced squamous cell carcinoma: a highly malignant form of esophageal cancer with SOX2 promoter hypermethylation[Refereed]Scientific journal
- Jan. 2018, Gastric Cancer, 21(1) (1), 162 - 170, EnglishHigher incidence of pancreatic fistula in laparoscopic gastrectomy. Real-world evidence from a nationwide prospective cohort study[Refereed]Scientific journal
- Jan. 2018, Gastric Cancer, 21(1) (1), 144 - 154, EnglishFive-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001-2007)[Refereed]Scientific journal
- Dec. 2017, SURGERY TODAY, 47(12) (12), 1539 - 1540, English[Refereed]
- Dec. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(13) (13), 3934 - 3946, English[Refereed]Scientific journal
- Dec. 2017, Surg Endosc, EnglishMorbidity and mortality from a propensity score-matched, prospective cohort study of laparoscopic versus open total gastrectomy for gastric cancer: data from a nationwide web-based database[Refereed]Scientific journal
- Dec. 2017, Dis Esophagus, 30(12) (12), 1 - 5, EnglishC-reactive protein to albumin ratio is a prognostic factor for patients with cStage II/III esophageal squamous cell cancer[Refereed]Scientific journal
- Background and study aims Endoscopic submucosal dissection (ESD) for duodenal tumors results in a high delayed perforation rate due to the thinness of the duodenal wall. In most cases with perforation after duodenal ESD, additional surgery is needed due to severe peritonitis. A newly developed procedure, laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS), may help to avoid perforation after ESD. In our institution, patients with superficial non-ampullary duodenal epithelial tumors (SNADET) smaller than 50 mm which could not have en-bloc resection by endoscopic mucosal resection were treated with D-LECS. After a laparoscopic exposure of anterior duodenal wall of second portion, ESD was performed. Laparoscopic suturing from the serosal side of ESD site was performed for reinforcement. There were neither postoperative leakage nor other complications. Therefore, D-LECS can be performed safely and prevent perforation after ESD for SNADET. D-LECS could be selected as a treatment for SNADET which can be cured by ESD.Nov. 2017, Endoscopy international open, 5(11) (11), E1153-E1158 - E1158, English, International magazine[Refereed]Scientific journal
- Nov. 2017, Oncotarget, 8(62) (62), 106071 - 106088, EnglishCXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells[Refereed]Scientific journal
- Nov. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(12) (12), 3673 - 3673, English[Refereed]Scientific journal
- Nov. 2017, 手術, 71(12) (12), 1645 - 1649, Japanese
- Nov. 2017, 消化器外科, 40(12) (12), 1681 - 1668, Japanese癌免疫カンファレンスルーム(第3回) 免疫抑制のメカニズム[Refereed]
- Nov. 2017, 日本外科学会雑誌, 118(6) (6), 639 - 645, Japanese【分子標的療法は外科治療をどう変えるか】 大腸癌[Refereed][Invited]
- Oct. 2017, MOLECULAR CANCER RESEARCH, 15(10) (10), 1455 - 1466, English[Refereed]Scientific journal
- Oct. 2017, J Invest Surg, EnglishIs Laparoscopic Distal Gastrectomy a Feasible Procedure for Elderly Patients With Gastric Cancer[Refereed]Scientific journal
- Oct. 2017, CANCERS, 9(10) (10), English[Refereed]
- Oct. 2017, 臨床外科, 72(10) (10), 1248 - 1253, Japanese
- Sep. 2017, SURGERY TODAY, 47(9) (9), 1060 - 1071, English[Refereed]Scientific journal
- Sep. 2017, DISEASES OF THE ESOPHAGUS, 30(9) (9), 1 - 7, English[Refereed]Scientific journal
- Sep. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(9) (9), 2727 - 2727, English[Refereed]Scientific journal
- Sep. 2017, ANN GASTROENTEROL SURG, 2(1) (1), 72 - 78, EnglishLong-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patients[Refereed]Scientific journal
- Aug. 2017, ANTICANCER RESEARCH, 37(8) (8), 4195 - 4198, English[Refereed]Scientific journal
- Aug. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(8) (8), 2302 - 2302, English[Refereed]Scientific journal
- Aug. 2017, 手術, 71(9) (9), 1335 - 1340, Japanese[Refereed]
- Jul. 2017, ANTICANCER RESEARCH, 37(7) (7), 3863 - 3869, English[Refereed]Scientific journal
- Jul. 2017, ANTICANCER RESEARCH, 37(7) (7), 3885 - 3890, English[Refereed]Scientific journal
- Jun. 2017, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 22(3) (3), 505 - 510, English[Refereed]Scientific journal
- Jun. 2017, Cytometry Research, 27(Suppl) (Suppl), 36, JapaneseiPS細胞を巡る最新の動向と今後の研究展開 人工癌幹細胞と癌オルガノイドを用いた癌幹細胞研究Research society
- May 2017, Cytometry research, 27(1) (1), 7 - 12, Japaneseα-galactosylceramide付加細胞投与によるNKT細胞活性化を介した抗腫瘍免疫療法[Refereed]Scientific journal
- May 2017, GASTRIC CANCER, 20(3) (3), 548 - 552, English[Refereed]Scientific journal
- May 2017, SURGERY, 161(5) (5), 1334 - 1340, English[Refereed]Scientific journal
- May 2017, JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 24(5) (5), 243 - 251, English[Refereed]Scientific journal
- May 2017, Cytometry Research, 27(1号) (1号), 33 - 39, Japanese[Refereed]
- Apr. 2017, 手術, 71(5) (5), 773 - 780, Japanese消化器外科医からみた大動脈食道瘻の治療戦略-その食道切除術と再建術[Refereed]Scientific journal
- Apr. 2017, ANNALS OF SURGICAL ONCOLOGY, 24(4) (4), 1018 - 1018, English[Refereed]Scientific journal
- Mar. 2017, SURGERY TODAY, 47(3) (3), 313 - 319, English[Refereed]Scientific journal
- Mar. 2017, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 31(3) (3), 1136 - 1141, English[Refereed]Scientific journal
- Mar. 2017, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 31(3) (3), 1496 - 1504, English[Refereed]Scientific journal
- 2017, 日本消化器外科学会雑誌(Web), 50(2) (2), 166‐176(J‐STAGE), Japanese
- 2017, 日本医用画像工学会大会予稿集, 36, 133 - 137, Japaneseスーパーピクセルと畳み込みニューラルネットワークを用いた腹腔鏡下手術における術具領域セグメンテーション(原著論文)[Refereed]Scientific journal
- Jan. 2017, CANCER MEDICINE, 6(1) (1), 258 - 266, English[Refereed]Scientific journal
- Jan. 2017, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 79(1) (1), 147 - 153, English[Refereed]Scientific journal
- Jan. 2017, WORLD JOURNAL OF CLINICAL CASES, 5(1) (1), 18 - 23, English[Refereed]Scientific journal
- Jan. 2017, INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 32(1) (1), 139 - 141, English[Refereed]Scientific journal
- 2017, EXPERT OPINION ON PHARMACOTHERAPY, 18(8) (8), 753 - 758, English[Refereed]Scientific journal
- 2017, 日本外科学会雑誌, 118(2) (2), 207 - 209, Japanese胃癌 1.病因論
- Dec. 2016, Surg Case Rep, 2(1) (1), 90, EnglishSuccessful resection of giant esophageal liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: a case report and literature review[Refereed]Scientific journal
- Dec. 2016, Surg Case Rep, 2(1) (1), 55, EnglishSuccessful laparoscopic distal gastrectomy with D2 lymph node dissection preserving the common hepatic artery branched from the left gastric artery for advanced gastric cancer with an Adachi type VI (group 26) vascular anomaly[Refereed]Scientific journal
- Nov. 2016, 癌と化学療法, 43(12号) (12号), 1443 - 1445, Japanese鼠径リンパ節転移を伴う進行直腸癌に対する術前化学放射線療法 手術による局所制御効果[Refereed]Scientific journal
- Nov. 2016, 癌と化学療法, 43(12号) (12号), 2193 - 2195, Japanese亜全胃温存膵頭十二指腸切除により切除し得た卵巣原発線維肉腫再発の1例[Refereed]Scientific journal
- Nov. 2016, J Geriatr Oncol, English[Refereed]Scientific journal
- Nov. 2016, Int Surg, EnglishPathological Complete Response after Preoperative Chemotherapy with a Regimen Containing Trastuzumab in Esophagogastric Junction Adenocarcinoma: A Case Report[Refereed]Scientific journal
- Oct. 2016, 消化器外科Nursing, (2016秋季増刊) (2016秋季増刊), 60 - 70, Japanese【周囲神経・血管・リンパ節までまるわかり!外科ナース・研修医のための消化器の手術&臓器のはたらき】 (3章)胃 胃の働きと解剖
- Oct. 2016, 消化器外科Nursing, (2016秋季増刊) (2016秋季増刊), 71 - 74, Japanese【周囲神経・血管・リンパ節までまるわかり!外科ナース・研修医のための消化器の手術&臓器のはたらき】 (3章)胃 だから胃手術後はどう注意する?
- Sep. 2016, Langenbecks Arch Surg, 401(6) (6), 797 - 804, English[Refereed]Scientific journal
- Sep. 2016, 日本外科学会雑誌, 117(5号) (5号), 465 - 467, JapaneseNCDの活用 デバイスラグ解消に向けて NCDを基盤とした消化器外科領域の前向き研究への課題[Refereed]Scientific journal
- Sep. 2016, Cancer Lett, 380(1) (1), 47 - 58, English[Refereed]Scientific journal
- Aug. 2016, Int Surg, EnglishTotally laparoscopic total gastrectomy in a patient with situs inversus totalis[Refereed]Scientific journal
- Aug. 2016, ONCOTARGET, 7(31) (31), 50150 - 50160, English[Refereed]Scientific journal
- Aug. 2016, Surg Laparosc Endosc Percutan Tech, 26(4) (4), 343 - 346, English[Refereed]Scientific journal
- Jul. 2016, Gastric Cancer, 19(3) (3), 976, English[Refereed]Scientific journal
- Jul. 2016, Anticancer Res, 36(7) (7), 3667 - 72, EnglishLiver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells[Refereed]Scientific journal
- Jul. 2016, Anticancer Res, 36(7) (7), 3659 - 65, EnglishHost CD40 Is Essential for DCG Treatment Against Metastatic Lung Cancer[Refereed]Scientific journal
- Jul. 2016, Anticancer Res, 36(7) (7), 3679 - 86, EnglishEffect of Xenotransplantation Site on MicroRNA Expression of Human Colon Cancer Stem Cells[Refereed]Scientific journal
- Jul. 2016, Ann Oncol, 27(7) (7), 1266 - 1272, English[Refereed]Scientific journal
- Jul. 2016, 癌と化学療法, 43(7号) (7号), 845 - 854, Japanese5-Fluorouracil(5-FU)の効果増強を目指した創薬の歴史と取り組み[Refereed]Scientific journal
- Jun. 2016, Sci Rep, 6, English[Refereed]Scientific journal
- Jun. 2016, 癌と化学療法, 43(6号) (6号), 715 - 722, Japaneseオキサリプラチンの10年間の軌跡[Refereed]
- Jun. 2016, 癌と化学療法, 43(6号) (6号), 707 - 714, Japaneseオキサリプラチンと5-FU併用による抗腫瘍効果の分子機序
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 30 - 31, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 大腸のしくみとはたらき 腸閉塞(イレウス)とはどのような症状?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 28 - 29, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 大腸のしくみとはたらき 大腸を切除したら体はどうなるの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 24 - 25, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 大腸のしくみとはたらき 大腸は体のどこにある? どんな構造をしているの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 26 - 27, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 大腸のしくみとはたらき 大腸のはたらきは?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 12 - 13, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 食道のしくみとはたらき 食道を切除したら体はどうなるの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 8 - 9, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 食道のしくみとはたらき 食道は体のどこにある? どんな構造をしているの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 10 - 11, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 食道のしくみとはたらき 食道のはたらきは?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 14 - 15, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 食道のしくみとはたらき 術後逆流性食道炎とはどのような症状?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 22 - 23, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 胃のしくみとはたらき 十二指腸の構造とはたらきは?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 20 - 21, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 胃のしくみとはたらき 胃を切除したら体はどうなるの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 16 - 17, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 胃のしくみとはたらき 胃は体のどこにある? どんな構造をしているの?
- Apr. 2016, 消化器外科Nursing, (2016春季増刊) (2016春季増刊), 18 - 19, Japanese【でっかくド~ン!オールカラー図解でみるみるわかる 新人ナースのための消化器外科 術前術後ケアQ&A102】 (1章)消化器臓器のしくみとはたらきQ&A 胃のしくみとはたらき 胃のはたらきは?
- Mar. 2016, 日本産科婦人科内視鏡学会雑誌, 31(2) (2), 469, Japanese[Refereed]Scientific journal
- Mar. 2016, Eur J Surg Oncol, 42(3) (3), 407 - 411, English[Refereed]Scientific journal
- Feb. 2016, JOURNAL OF CLINICAL ONCOLOGY, 34(4) (4), English[Refereed]
- Feb. 2016, SURGERY, 159(2) (2), 459 - 466, English[Refereed]Scientific journal
- 2016, Cancer Sci., 107(3) (3), 290, English[Refereed]Doctoral thesis
- 2016, Dis Esophagus., 29(2) (2), 146, English[Refereed]Scientific journal
- Jan. 2016, Asian J Endosc Surg, 9(2) (2), 121, English[Refereed]Scientific journal
- 2016, Cytometry research, 26(2) (2), 27 - 31, Japanese[Refereed]
- 2016, Cytometry research, 26(2) (2), 7 - 13, Japanese[Refereed]
- 2016, Cytometry research, 26(2) (2), 21 - 25, Japanese[Refereed]
- Dec. 2015, Cancer Sci, 107(3) (3), 297, English[Refereed]Scientific journal
- Dec. 2015, Ann Surg Oncol, 22, 1067 - 1074, English[Refereed]Scientific journal
- Dec. 2015, Ann Surg Oncol, 22, 1067 - 1074, English[Refereed]Scientific journal
- Dec. 2015, Ann Surg Oncol, 22, 335, English[Refereed]Scientific journal
- Dec. 2015, Ann Surg Oncol, 22, 355, English[Refereed]Scientific journal
- Nov. 2015, 癌と化学療法, 42(12号) (12号), 1457 - 1459, Japanese食道癌根治切除後再発に対してSalvage Chemoradiotherapy(CRT)により長期生存が得られた1例[Refereed]Scientific journal
- Nov. 2015, 癌と化学療法, 42(12号) (12号), 2202 - 2204, Japaneseクローン病長期寛解後に同時性多発大腸癌を発症した1例[Refereed]Scientific journal
- Nov. 2015, Ann Oncol, 26(11) (11), 2274 - 2280, English[Refereed]Scientific journal
- Nov. 2015, Gastric Cancer, 19(3) (3), 851, English[Refereed]Scientific journal
- Nov. 2015, 外科, 77(12号) (12号), 1452 - 1455, Japanese【外科修練医必修 新外科専門医到達のための特別講義】 麻酔科学 硬膜外麻酔の原理
- Oct. 2015, Onco Targets Ther, 8, 3169 - 3173, English[Refereed]Scientific journal
- Oct. 2015, 癌と化学療法, 42(10号) (10号), 1252 - 1255, JapaneseNK細胞浸潤がヒト乳がん異種移植マウスの腫瘍増殖に与える影響[Refereed]Scientific journal
- Oct. 2015, 癌と化学療法, 42(10号) (10号), 1148 - 1151, Japanese【化学放射線療法の現況と展望】 食道癌に対する化学放射線療法の現況と展望
- Sep. 2015, BMC Res Notes, 8(1) (1), English[Refereed]Scientific journal
- Sep. 2015, Int Surg, 100(9-10) (9-10), 1326 - 1331, English[Refereed]Scientific journal
- Sep. 2015, Int J Clin Oncol, 21(2) (2), 349, English[Refereed]Scientific journal
- Sep. 2015, Ann Oncol, 26(9) (9), 1916 - 1922, English[Refereed]Scientific journal
- Sep. 2015, Surg Today, 46(7) (7), 820, English[Refereed]Scientific journal
- Sep. 2015, 癌の臨床, 61(4号) (4号), 283 - 287, Japanese【胃がん治療戦略のUp to Date】 胃癌における機能温存手術
- Aug. 2015, Anticancer Res, 35(8) (8), 4425 - 31, EnglishEarly-phase Treatment by Low-dose 5-Fluorouracil or Primary Tumor Resection Inhibits MDSC-mediated Lung Metastasis Formation[Refereed]Scientific journal
- Aug. 2015, Gastric Cancer, 19(3) (3), 851, English[Refereed]Scientific journal
- May 2015, Lab Invest, 95(5) (5), 491 - 503, English[Refereed]Scientific journal
- May 2015, Ann Surg Oncol, 22(5) (5), 1548 - 1554, English[Refereed]Scientific journal
- Apr. 2015, 消化器外科学レビュー, 16, 186, Japanese癌の遺伝子診断・治療[Refereed]Scientific journal
- Apr. 2015, Hernia, 19(Suppl 1) (Suppl 1), S293 - 304, EnglishTopic: Inguinal Hernia - Unsolved problem in the daily practice[Refereed]Scientific journal
- Apr. 2015, Lab. Invest, 95(5) (5), 491 - 503, English[Refereed]Scientific journal
- Apr. 2015, Surg Endosc, 29(4) (4), 1001, English[Refereed]Scientific journal
- Mar. 2015, Oncol Lett, 9(6) (6), 2583 - 2585, English[Refereed]Scientific journal
- Mar. 2015, Cancer Med, 4(3) (3), 437 - 446, English[Refereed]Scientific journal
- Feb. 2015, Ann Thorac Cardiovasc Surg, 21(3) (3), 289 - 292, English[Refereed]Scientific journal
- Jan. 2015, JOURNAL OF CLINICAL ONCOLOGY, 33(3) (3), English[Refereed]
- Jan. 2015, GASTRIC CANCER, 18(1) (1), 119 - 128, English[Refereed]Scientific journal
- Jan. 2015, 医薬ジャーナル, 51(S-1) (S-1), 147 - 155, Japanese新薬展望2015 第III部 治療における最近の新薬の位置付け「薬効別」 ~新薬の広場~ 消化器癌治療薬[Refereed]Scientific journal
- Jan. 2015, Surg Endosc, 29(11) (11), 3386 - 3391, English[Refereed]Scientific journal
- Jan. 2015, Indian J Surg, 77, 1462 - 1465, English[Refereed]Scientific journal
- Jan. 2015, Int J Clin Oncol, 20(4) (4), 775, English[Refereed]Scientific journal
- Jan. 2015, Langenbecks Arch Surg, 400(1) (1), 113 - 117, English[Refereed]Scientific journal
- Jan. 2015, Medicine (Baltimore), 94(4) (4), e501, English[Refereed]Scientific journal
- Jan. 2015, Anticancer Res, 35(1) (1), 511 - 5, EnglishAssessment of surgical treatment and postoperative nutrition in gastric cancer patients older than 80 years[Refereed]Scientific journal
- Jan. 2015, メディカル朝日, 44(1号) (1号), 34 - 35, Japanese胃がん治療戦略のUp to Date 胃癌における機能温存手術
- Jan. 2015, 医薬ジャーナル, 51(増刊) (増刊), 365 - 373, Japanese【新薬展望2015】 (第III部)治療における最近の新薬の位置付け[薬効別] 新薬の広場 消化器癌治療薬
- Jan. 2015, 手術, 69(1号) (1号), 53 - 58, Japanese【食道・胃手術-合併症ゼロを目指した秘策-】 胃全摘後の各種再建法と合併症対策[Refereed]
- Dec. 2014, 外科, 76(13号) (13号), 1630 - 1635, Japanese臨床経験 根治切除不能なStageIV大腸癌に対して原発巣切除を先行する意義[Refereed]Scientific journal
- Dec. 2014, Dis Esophagus, EnglishChanges in modified Glasgow prognostic score after neoadjuvant chemotherapy is a prognostic factor in clinical stage II/III esophageal cancer[Refereed]Scientific journal
- Nov. 2014, 癌と化学療法, 41(12号) (12号), 1875 - 1877, Japanese術前化学放射線療法により腹腔鏡下直腸切断術を施行した進行痔瘻癌の1例[Refereed]Scientific journal
- Nov. 2014, Anticancer Res, 34(11) (11), 6655 - 62, EnglishLiver resectability of advanced liver-limited colorectal liver metastases following mFOLFOX6 with bevacizumab (KSCC0802 Study)[Refereed]Scientific journal
- Nov. 2014, Surg Today, 44(11) (11), 2187 - 2190, English[Refereed]Scientific journal
- Nov. 2014, CRSLS MIS Case Reports, epub, EnglishCurable Resection in Gastric and Lymph Node Metastases from Melanoma[Refereed]Scientific journal
- Oct. 2014, Surg Endosc, 29(8) (8), 2442 - 2450, English[Refereed]Scientific journal
- Sep. 2014, World J Gastroenterol, 20(34) (34), 12341 - 12345, English[Refereed]Scientific journal
- Sep. 2014, Int Surg, 99(4) (4), 640 - 644, English[Refereed]Scientific journal
- Aug. 2014, Anticancer Res, 34(8) (8), 3911 - 5, EnglishIntratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer[Refereed]Scientific journal
- Jul. 2014, World J Gastroenterol, 20(25) (25), 8317 - 8319, English[Refereed]Scientific journal
- Jul. 2014, Anticancer Res, 34(7) (7), 3411 - 7, EnglishAllogeneic DCG promote lung NK cell activation and antitumor effect after invariant NKT cell activation[Refereed]Scientific journal
- Jul. 2014, 消化器外科Nursing, 19(7号) (7号), 676 - 678, Japanese【「キャッチフレーズ 図解」でさくさくわかる!消化器外科看護のための解剖生理・機能解剖】 胃 胃の解剖は?
- Jul. 2014, 消化器外科Nursing, 19(7号) (7号), 679 - 681, Japanese【「キャッチフレーズ 図解」でさくさくわかる!消化器外科看護のための解剖生理・機能解剖】 胃 胃のはたらきは?
- Jun. 2014, Cancer Chemother Pharmacol, 73(6) (6), 1253 - 1261, English[Refereed]Scientific journal
- Jun. 2014, 臨床外科, 69(6) (6), 674 - 679, Japanese[Refereed]
- May 2014, Scand J Gastroenterol, 49(5) (5), 581 - 588, English[Refereed]Scientific journal
- May 2014, Surg Today, 45(2) (2), 209 - 214, English[Refereed]Scientific journal
- May 2014, Eur J Surg Oncol, 40(5) (5), 559 - 566, English[Refereed]Scientific journal
- Apr. 2014, Surg Endosc, 28(4) (4), 1250 - 1255, English[Refereed]Scientific journal
- Apr. 2014, Dis Esophagus, 27(3) (3), 285 - 293, English[Refereed]Scientific journal
- Apr. 2014, JSLS, 18(2) (2), 314 - 318, English[Refereed]Scientific journal
- Mar. 2014, SURGICAL SCIENCE, 5(1) (1), 122 - 127, English[Refereed]Scientific journal
- Mar. 2014, Ann Surg Oncol, 21(7) (7), 2340 - 2346, English[Refereed]Scientific journal
- Mar. 2014, Surg Today, 44(3) (3), 454 - 461, English[Refereed]Scientific journal
- Feb. 2014, Ann Surg Oncol, 21(2) (2), 597 - 604, English[Refereed]Scientific journal
- Dec. 2013, Cancer Sci, 104(12) (12), 1718 - 1725, English[Refereed]Scientific journal
- Dec. 2013, Oncol Rep, 30(6) (6), 2609 - 2616, English[Refereed]Scientific journal
- Oct. 2013, Anticancer Res, 33(10) (10), 4515 - 9, EnglishThoracoscopic esophagectomy in the prone position for esophageal cancer with right aortic arch: case report[Refereed]Scientific journal
- Oct. 2013, Ann Surg Oncol, 21(2) (2), 597 - 604, English[Refereed]Scientific journal
- Aug. 2013, Cancer Sci, 104(8) (8), 1112 - 1119, English[Refereed]Scientific journal
- Aug. 2013, Surg Today, 44(8) (8), 1573 - 1576, English[Refereed]Scientific journal
- Aug. 2013, Mol Carcinog, 52(8) (8), 619 - 626, English[Refereed]Scientific journal
- Aug. 2013, AJR Am J Roentgenol, 201(2) (2), 253 - 261, English[Refereed]Scientific journal
- May 2013, World J Gastroenterol, 19(17) (17), 2683 - 2690, English[Refereed]Scientific journal
- Apr. 2013, Int J Clin Oncol, 18(2) (2), 254 - 259, English[Refereed]Scientific journal
- Mar. 2013, BMC CANCER, 13, English[Refereed]Scientific journal
- There have been no reports of gastric gastrointestinal stromal tumors (GISTs) <20 mm with distant metastasis. We report a case of a 15-mm gastric GIST with liver metastasis 1 year after surgical resection of the primary lesion. A 35-year-old man underwent routine esophagogastroduodenoscopy in July 2009. A submucosal tumor (SMT) <20 mm was incidentally detected at the posterior wall of the gastric body. Endoscopic ultrasound (EUS) indicated that it was a gastrointestinal mesenchymal tumor, including GIST, leiomyoma or schwannoma. He did not accept regular follow-up for this gastric SMT, therefore local laparoscopic excision was carried out in October 2009. The final pathological diagnosis after surgery was GIST, 15 mm in size, and a mitotic rate of 7/50 high-power fields, which did not indicate a high metastatic risk. The patient was followed up regularly without adjuvant chemotherapy. At 1 year after surgery, a space-occupying lesion ~15 mm was detected in the left lobe of the liver by abdominal ultrasound, where no mass lesion had been observed before surgery. To make a definite diagnosis of the hepatic mass lesion, EUS-guided fine-needle aspiration was performed, which demonstrated a metastatic liver tumor from a gastric GIST. Although this was a rare case, we should keep in mind that gastric GISTs do have a chance of malignant behavior, even if <20 mm.Feb. 2013, Clinical journal of gastroenterology, 6(1) (1), 29 - 32, English, Domestic magazine[Refereed]Scientific journal
- Feb. 2013, World J Gastrointest Surg, 5(2) (2), 22 - 6, EnglishLaparoscopic hemicolectomy in a patient with situs inversus totalis after open distal gastrectomy[Refereed]Research society
- Feb. 2013, Int J Cancer, 132(4) (4), 951 - 958, English[Refereed]Scientific journal
- Feb. 2013, Int J Clin Oncol, 18(1) (1), 38 - 45, English[Refereed]Scientific journal
- 2013, Am J Pediatr Hematol Oncol, 84(4) (4), 233 - 239, English[Refereed]Scientific journal
- 2013, Asian Pac J Cancer Prev, 14(11) (11), 6249 - 6256, English[Refereed]Scientific journal
- Jan. 2013, Surg Endosc, 27(1) (1), 325 - 332, English[Refereed]Scientific journal
- Jan. 2013, Dis Esophagus, 26(1) (1), 50 - 56, English[Refereed]Scientific journal
- Jan. 2013, Surg Today, 43(1) (1), 73 - 80, English[Refereed]Scientific journal
- Jan. 2013, GASTRIC CANCER, 16(1) (1), 94 - 99, English[Refereed]Scientific journal
- Dec. 2012, ESOPHAGUS, 9(4) (4), 228 - 233, English[Refereed]Scientific journal
- Dec. 2012, Genes Cells, 17(12) (12), 962 - 970, English[Refereed]Scientific journal
- Nov. 2012, Int J Clin Oncol, 18(6) (6), 1042 - 1048, English[Refereed]Scientific journal
- Oct. 2012, 日本癌治療学会誌, 47(3号) (3号), 2304, Japanese新規抗癌剤治療を行ったS状結腸腺扁平上皮癌多発肝転移の1例Research society
- Oct. 2012, Ann Surg Oncol, 19(11) (11), 3627 - 3635, English[Refereed]Scientific journal
- Oct. 2012, GASTRIC CANCER, 15(4) (4), 363 - 369, English[Refereed]Scientific journal
- Aug. 2012, Surg Today, 42(8) (8), 734 - 740, English[Refereed]Scientific journal
- Aug. 2012, Surg Today, 42(8) (8), 752 - 758, English[Refereed]Scientific journal
- Aug. 2012, Nutr Cancer, 64(6) (6), 798 - 805, English[Refereed]Scientific journal
- Jul. 2012, Surg Today, 42(7) (7), 625 - 632, English[Refereed]Scientific journal
- Jun. 2012, Surg Today, 42(6) (6), 554 - 558, English[Refereed]Scientific journal
- May 2012, JOURNAL OF CLINICAL ONCOLOGY, 30(15) (15), EnglishPhase II study of combination therapy with S-1 and cetuximab in patients with KRAS wild-type unresectable colorectal cancer who had previously received irinotecan, oxaliplatin, and fluoropyrimidines (KSCC0901).[Refereed]
- May 2012, Ann Surg Oncol, 19(5) (5), 1499 - 1507, English[Refereed]Scientific journal
- May 2012, Surg Today, 42(5) (5), 426 - 430, English[Refereed]Scientific journal
- Apr. 2012, Surg Today, 42(4) (4), 351 - 358, English[Refereed]Scientific journal
- Apr. 2012, Ann Surg Oncol, 19(4) (4), 1145 - 1152, English[Refereed]Scientific journal
- Apr. 2012, BREAST CANCER, 19(2) (2), 161 - 169, English[Refereed]Scientific journal
- Apr. 2012, J Gastroenterol, 47(4) (4), 351 - 358, English[Refereed]
- Mar. 2012, DNA Repair (Amst), 11(3) (3), 247 - 258, English[Refereed]Scientific journal
- Feb. 2012, Surg Today, 42(3) (3), 225 - 232, English[Refereed]Scientific journal
- Feb. 2012, 消化器外科, 35(2) (2), 201 - 207, Japanese【胃癌診療のトピックス】 切除不能・再発胃癌の化学療法のup to date(解説/特集)[Invited]
- 2012, Genes Genet Syst, 87(4) (4), 265 - 272, English[Refereed]Scientific journal
- 2012, J Epidemiol, 22(1) (1), 64 - 71, English[Refereed]Scientific journal
- Jan. 2012, Surg Today, 42(1) (1), 52 - 59, English[Refereed]Scientific journal
- Jan. 2012, Surg Today, 42(1) (1), 8 - 28, English[Refereed]Scientific journal
- Jan. 2012, 外科, 74(1号) (1号), 31 - 36, Japanese【手術助手にはこうしてほしい】 消化管領域 腹腔鏡下胃全摘術
- Jan. 2012, Surg Today, 42(2) (2), 111 - 120, English[Refereed]
- Dec. 2011, Scandinavian Journal of Gastroenterology, 46(2) (2), 165 - 172, English[Refereed]Scientific journal
- Dec. 2011, Surgery today, 41(12) (12), 1592 - 1598[Refereed]
- 9, Sep. 2011, Surgery today, 41(9) (9), 1290 - 1293[Refereed]
- Sep. 2011, Annals of surgical oncology, 18(9) (9), 2613 - 2621[Refereed]
- Jun. 2011, Annals of surgical oncology, 18(6) (6), 1757 - 1765[Refereed]
- 2011, Asian Pac J Cancer Prev, 12(8) (8), 2025 - 30, EnglishConstipation and colorectal cancer risk: the Fukuoka Colorectal Cancer Study[Refereed]Scientific journal
- Apr. 2010, International journal of clinical oncology, 15(2) (2), 135 - 144[Refereed]
- Mar. 2010, Cancer science, 101(3) (3), 639 - 645[Refereed]
- 1, 2009, Surgery today, 39(1) (1), 59 - 63[Refereed]
- Mar. 2008, Journal of surgical oncology, 97(3) (3), 231 - 235, English[Refereed]
- 1-4, 2008, Journal of gastrointestinal cancer, 39(1-4) (1-4), 82 - 85[Refereed]
- Jan. 2008, Hepato-gastroenterology, 55(81) (81), 103 - 107, EnglishAdenocarcinoma of the esophagogastric junction in Japan.[Refereed]
- Sep. 2007, Anticancer research, 27(5A) (5A), 3345 - 3353Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and p16INK4a) gene in esophageal squamous cell carcinoma.[Refereed]
- Sep. 2007, Anticancer research, 27(5B) (5B), 3501 - 3506Expression of p53 and p21 and the clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus.[Refereed]
- Jun. 2006, Gan to kagaku ryoho. Cancer & chemotherapy, 33 Suppl 1, 138 - 143, Japanese[A randomized controlled trial to evaluate the effect of adjuvant oral fluoropyrimidine derivative therapy after curative resection for stage II/III rectal cancer-adjuvant chemotherapy trial of S-1 for rectal cancer (ACTS-RC):].[Refereed]
- Apr. 2006, Oncology reports, 15(4) (4), 849 - 854Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric cancer.[Refereed]
- Oct. 2005, Gan to kagaku ryoho. Cancer & chemotherapy, 32(10) (10), 1389 - 1392, Japanese[Evaluation of positive cases with peritoneal lavage cytology in gastric cancer].[Refereed]
- Nov. 2004, Gan to kagaku ryoho. Cancer & chemotherapy, 31(12) (12), 1978 - 1981, Japanese[Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].[Refereed]
- Jan. 2004, Hepato-gastroenterology, 51(55) (55), 298 - 302, EnglishPostoperative morbidity/mortality and survival rates after total gastrectomy, with splenectomy/pancreaticosplenectomy for patients with advanced gastric cancer.[Refereed]
- Nov. 2003, Oncology reports, 10(6) (6), 1747 - 1751, EnglishVascular endothelial growth factor C expression correlates with lymphatic involvement and poor prognosis in patients with esophageal squamous cell carcinoma.[Refereed]
- Jan. 2002, Surgery, 131(1 Suppl) (1 Suppl), S85 - 91, English[Refereed]Scientific journal
- 2001, Oncology Reports, 8, 107 - 110, EnglishGastric cancer with high telomerase activity shows rapid development and invasiveness.[Refereed]Scientific journal
- 1999, Oncol Reports, 6, 995 - 999, EnglishThymidine Phosphorylase Activity and Angiogenesis in Gastric Cancer.[Refereed]Scientific journal
- 1999, Oncol Reports, 6(6) (6), 1213 - 1216, EnglishHeterogeneity and clinical role of thymidine phospholyrase activity in gastric cancer.[Refereed]Scientific journal
- 1999, Gastric Cancer, 2, 46 - 51, EnglishClinical significance of micrometastasis in bone marrow of patients with gastric cancer and its relation to angiogenesis.[Refereed]Scientific journal
- 1998, Cancer, 82(12) (12), 2307 - 2311, English[Refereed]Scientific journal
- 1997, Investigational New Drugs, 15(1) (1), 39 - 48, English[Refereed]Scientific journal
- 1997, Int. J. Rad. Oncol. Biol. Phys, 37(5) (5), 1115 - 1123, English[Refereed]Scientific journal
- 1996, J Am Coll Surg, 182, 482 - 487, EnglishArgyrophilic Nucleolar Organizer Region (AgNOR) in endoscopically biopsied tissues is an useful predictor of gastric malignancy.[Refereed]Scientific journal
- 1995, J Surg Oncol, 59, 215 - 219, EnglishSurgical treatment for gastric carcinoma with duodenal invasion.[Refereed]Scientific journal
- 1995, Br J Cancer, 71(1) (1), 191 - 195, English[Refereed]Scientific journal
- 1994, Br J Cancer, 69, 749 - 753, EnglishProliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.[Refereed]Scientific journal
- 1994, Semin Surg Oncol, 10, 130 - 134, EnglishHelix Pomatia Agglutinin binding activity and lymph node metastasis in patients with gastric cancer.[Refereed]Scientific journal
- 1993, J Surg Oncol, 52(4) (4), 207 - 212, EnglishPrognostic significance of tumor-host interaction in clinical gastric cancer : relationship between DNA ploidy and dendritic cell infiltration.[Refereed]Scientific journal
- 1993, Br J Cancer, 67(3) (3), 589 - 593, EnglishGastric cancer with p53 overexpression has high potential for metastasising to lymph nodes.[Refereed]Scientific journal
- 1991, Cancer Res, 51(7) (7), 3503 - 3506, EnglishPredictive value of Ki-67 and argyrophilic nucleolar organizer region staining for lymph node metastasis in gastric cancer.[Refereed]Scientific journal
- 1991, Cancer, 68(11) (11), 2438 - 2442, EnglishHelix pomatia agglutinin binding activity is a predictor of survival time for patients with gastric carcinoma.[Refereed]Scientific journal
- 1991, Cancer, 68(2) (2), 380 - 384, EnglishClinicopathologic features and prognostic significance of duodenal invasion in patients with distal gastric carcinoma.[Refereed]Scientific journal
- 胃癌, 株式会社へるす出版, Apr. 2024がん治療YearBook Key Reference 2022-2023
- (4章)しっかり消化!胃・十二指腸のすべて 疾患編 胃GIST, メディカ出版, Oct. 2023, Japanese, ISBN: 9784840480277決定版!まるごと知りたい消化管 : 解剖生理も、最新の治療も、患者ケアも
- (4章)しっかり消化!胃・十二指腸のすべて 疾患編 胃がん, メディカ出版, Oct. 2023, Japanese, ISBN: 9784840480277決定版!まるごと知りたい消化管 : 解剖生理も、最新の治療も、患者ケアも
- 11-5-15 腸閉塞(イレウス), 朝倉書店, Mar. 2022, ISBN: 9784254322804内科学
- Joint work, 2章がん微小環境 Keyword8 血管新生, 株式会社羊土社, Mar. 2022がん免疫ペディア 腫瘍免疫学・がん免疫療法の全てをまるごと理解!
- Joint work, 第5章 無菌法(消毒法および減菌法), 株式会社医学書院, Mar. 2022標準外科学
- 食道上皮性良性腫瘍、食道粘膜下腫瘍, Nov. 2021専門医のための消化器病学 第3版
- II.がんロコモ治療に必要ながん医療の基礎知識 2治療総論 2)手術治療, 総合医学社, Oct. 2021, Japanese, ISBN: 9784883787401チーム医療のためのがんロコモハンドブック
- Others, 医学書院, Jan. 2019, Japanese標準外科学(第15版) / 無菌法(消毒法および滅菌法)Textbook
- Others, 株式会社メジカルビュー, Dec. 2018, Japanese改訂第2版 5年でマスター 消化器標準手術 消化器外科専門医への道 / 胃瘻造設術Scholarly book
- Others, 寺田国際事務所/先端医療技術研究所, Aug. 2018, Japanese先端医療シリーズ49 消化器疾患の最新医療 / National Clinical Databaseの役割Scholarly book
- Others, 医歯薬出版株式会社, Aug. 2018, Japanese医療のあゆみBOOKS エビデンス 漢方診療 / 癌治療における漢方治療Scholarly book
- Editor, 長谷川 素美, Jan. 2018, Japaneseメディカ出版 / 考える外科 上部消化管外科の治療戦略General book
- Others, Springer Science + Business Media, 2013, EnglishPatient Surveillance After Cancer Treatment / Stomach Carcinoma Surveillance Counterpoint: JapanScholarly book
- 第96回日本胃癌学会総会, English, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conferenceThe significance of conversion surgery following chemotherapy for clinical stage IV gastric cancerOral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference当院における進行胃癌に対するロボット支援下胃切除術の工夫Oral presentation
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性Public symposium
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conferenceプレナリーセッション 1 胃癌学会施設認定制度についてOthers
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学・アステラス製薬株式会社, 京都市, Japan, Domestic conferenceランチョンセミナー 9 胃癌のバイオマーカーOthers
- 第96回日本胃癌学会総会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, Japan, Domestic conference胃癌学会の取り組みInvited oral presentation
- 消化器がんエドルミズセミナー, Japanese, 小野薬品工業株式会社, 神戸/Web, Japan, Domestic conference特別講演「がん悪液質における集学的支持療法の重要性~チーム医療で”体重減少”に挑む」Others
- 第39回日本臨床栄養代謝学会学術集会, Japanese, 東邦大学医学部臨床支援室・東邦大学医療センター大森病院栄養治療センター, 横浜, Japan, Domestic conference合同パネルディスカッション6「がん治療と栄養」Others
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討Oral presentation
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績Public symposium
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference大腸癌腫瘍免疫微小環境における CD4+T 細胞に与える肥満の影響Oral presentation
- 第56回制癌剤適応研究会, Japanese, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, Japan, Domestic conference鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績;術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略Oral presentation
- The 19th Annual Academic Surgical Congress, English, Annual Academic Surgical Congress, Washington, D.C., United States, International conferenceClinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRTOral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性についての検討Oral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座, 枚方市, Japan, Domestic conferenceリンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性Oral presentation
- 第207回近畿外科学会, Japanese, 関西医科大学 外科学講座・インテュイティブサージカル合同会社, 枚方市, Japan, Domestic conference特別講演1 ロボット手術の次世代への継承~教育体制とテクノロジーの活用~Others
- 奈良県総合医療センター集学的がん治療セミナー, Japanese, 奈良県総合医療センター・株式会社ツムラ, 奈良市/Web, Japan, Domestic conference集学的治療における漢方薬の役割Invited oral presentation
- 日本消化器病学会近畿支部第74回教育講演会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, Japan, Domestic conference消化器領域のがんゲノム医療Others
- 日本消化器病学会近畿支部第120回例会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, Japan, Domestic conference当院におけるTaTME併用大腸全摘術の手術成績Public symposium
- 日本消化器病学会近畿支部第120回例会, Japanese, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野・MSD株式会社, 神戸, Japan, Domestic conferenceアフタヌーンセミナー4「根治切除を視野に入れた食道癌治療戦略」~CAREからCUREを目指してOthers
- 第100回大腸癌研究会学術集会, Japanese, 東京女子医科大学 消化器・一般外科, 東京, Japan, Domestic conference下部進行直腸癌に対する術前化学放射線療法+選択的側方郭清の治療成績Poster presentation
- 第12回若手消化器外科腹腔鏡セミナー, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野/肝胆膵外科学分野, 神戸, Japan, Domestic conference閉会の挨拶Others
- 第194回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討Oral presentation
- 第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Oral presentation
- 第36回日本バイオセラピィ学会学術集会総会, Japanese, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, Japan, Domestic conference大腸癌腫瘍免疫微小環境における CD4+T 細胞に与える肥満の影響Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference安全な Collard 変法吻合を目指した変革と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceロボット支援胃切除術におけるリンパ節郭清時間の learning curveOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomyOral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference経肛門アプローチ併用による2チーム側方郭清の手術手技と手術成績Public symposium
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conference人間工学に基づく「鏡視下クロソイド・カーブ針」の開発Oral presentation
- 第36回日本内視鏡外科学会総会, Japanese, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, Japan, Domestic conferenceワークショップ27 NCD 解析で判った内視鏡外科のエビデンス創出-ビックデータを如何使うか-Others
- 第32回日本コンピュータ外科学会大会, Japanese, 鹿児島大学学術研究院医歯学域医学系 小児外科学分野, 鹿児島, Japan, Domestic conferenceどうするJSCASの今後Oral presentation
- KOBEヘルニアセミナー, Japanese, コヴィディエンジャパン株式会社, 神戸/Web, Japan, Domestic conference開会の辞Others
- KOBEヘルニアセミナー, Japanese, コヴィディエンジャパン株式会社, 神戸/Web, Japan, Domestic conference総合座長Others
- 第44回日本肥満学会・第41回日本肥満症治療学会学術集会, Japanese, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, Japan, Domestic conference当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討Poster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference食道扁平上皮癌とマクロファージとの直接共培養により発現亢進するIFI16はIL-1αの分泌を介して腫瘍進展に関与するPoster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野・ミヤリサン製薬株式会社, 高崎, Japan, Domestic conference消化器癌と腸内細菌Public discourse
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conferenceCDX2低発現大腸癌の臨床学的予後と腫瘍生物学的特性についての解析Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference脂肪細胞によるがん幹細胞性制御機構Poster presentation
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference大腸癌手術前後における腸内細菌と代謝物の変化についての検討Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conference放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態Public symposium
- 第34回日本消化器癌発生学会総会, Japanese, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, Japan, Domestic conferenceシンポジウム2「一歩進んだ腫瘍免疫研究」Others
- 第85回日本臨床外科学会総会, Japanese, 川崎医科大学総合医療センター, 岡山, Japan, Domestic conference女性外科医がAcademic surgeonとして多方面で活躍するために 働き方改革を契機としたインセンティブ導入の提言Oral presentation
- 第85回日本臨床外科学会総会, Japanese, 川崎医科大学総合医療センター, 岡山, Japan, Domestic conference[総会特別企画10-2-1] 女性外科医がAcademic surgeon として多方面で活躍するために 働き方改革を契機としたインセンティブ導入の提言Others
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conferenceリアルワールドデータを用いた食道扁平上皮癌に対する術前補助化学療法/化学放射線療法の治療成績比較Oral presentation
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性Oral presentation
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conferenceランチョンセミナー4 食道がん治療の最前線 ~経験を踏まえた治療戦略~Others
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conferenceリンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Oral presentation
- 第74回日本気管食道科学会総会ならびに学術講演会, Japanese, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, Japan, Domestic conference学会臨床研究発表会Others
- 第53回胃外科・術後障害研究会, Japanese, 埼玉医科大学国際医療センター消化器外科, 東京, Japan, Domestic conference要望演題8 残胃癌Others
- オプジーボ胃癌一次治療 2周年記念講演会, Japanese, Web, Japan, Domestic conferenceOpening RemarksOthers
- 第3回兵庫胃ビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, 神戸, Japan, Domestic conference特別講演「新規ロボット導入のコツとHybrid RAS」Others
- シンバイオティクスセミナー~腸内細菌叢の基礎と臨床~, Japanese, 株式会社ヤクルト本社, Web, Japan, Domestic conferencesession3 消化器癌パート「消化器疾患における腸内細菌叢のインパクト」Others
- Asahi Web Meeting~集中治療から DIC 管理まで考える~, Japanese, 旭化成ファーマ株式会社, Web, Japan, Domestic conference講演I 「敗血症における支持療法~DIC を中心に~」Others
- 第31回日本消化器関連学会週間(JDDW2023), Japanese, 一般社団法人 日本消化器関連学会機構, 神戸/Web, Japan, Domestic conference切除不能Stage4大腸癌においてCDX2の発現低下は予後予測因子であるPoster presentation
- 第31回日本消化器関連学会週間(JDDW2023), Japanese, 一般社団法人 日本消化器関連学会機構, 神戸/Web, Japan, Domestic conference招待講演(消化器外科学会) Science and art in colorectal surgeryOthers
- 第31回日本消化器関連学会週間(JDDW2023), Japanese, 一般社団法人 日本消化器関連学会機構, 神戸/Web, Japan, Domestic conference統合プログラム4(PD)(JDDW・消化器病学会・消化器内視鏡学会・肝臓学会・消化器外科学会・消化器がん検診学会) 臨床研究の支援体制と実施体制の強化Others
- 第26回腹腔鏡内視鏡合同手術研究会, Japanese, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, Japan, Domestic conference十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討Oral presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceClinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRTPoster presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resectionPoster presentation
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, English, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, Japan, International conferenceSpecial Seminar 2 「Current Status of Robotic Surgery for Rectal Cancer in Japan and its future Prospects」Others
- 第76回日本胸部外科学会定期学術集会, Japanese, 東北大学大学院医学系研究科 心臓血管外科学分野, 仙台, Japan, Domestic conference【 JATS 】ワークショップ 食道2 食道癌手術の周術期管理を考えるOthers
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceThe significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resectionOral presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceAlbumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinomaOral presentation
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceAOS Symposium1 AI oncology in Asian countriesOthers
- The 3rd International Congress of the Asian Oncology Society (AOS2023), English, Department of Urology, Keio University School of Medicin, Yokohama, Japan, International conferenceClinical outcomes of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for metastasised low rectal cancerOral presentation
- 第61回日本癌治療学会学術集会, Japanese, 慶應義塾大学医学部 泌尿器科学教室, 横浜, Japan, Domestic conference当院における食道癌術前 DCF 療法と術前 CF 療法の後方視的検討Poster presentation
- 第61回日本癌治療学会学術集会, Japanese, 慶應義塾大学医学部 泌尿器科学教室, 横浜, Japan, Domestic conference臓器別ワークショップ8 食道癌・食道胃接合部癌 -世界と日本の治療は共存可能か?-Others
- Colorectal Cancer Seminar ~大腸がん治療の最新情報~, Japanese, メルクバイオファーマ株式会社, 博多, Japan, Domestic conference特別講演③ 「大腸癌薬物療法~DEEPER試験を踏まえて~」Others
- 神戸消化器癌フォーラム2023@Web, Japanese, 日本化薬株式会社, Web, Japan, Domestic conference胃癌に対する最新集学的治療2023Invited oral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference右肺腺癌虫垂転移に対して腹腔鏡下回盲部切除術を施行した1例Oral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference腹腔鏡下に切除し得た成人骨盤嚢胞性腫瘤の2例Oral presentation
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブPublic symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conferenceリンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性Public symposium
- 第36回近畿内視鏡外科研究会, Japanese, 近畿大学医学部外科学 下部消化管部門, 豊中, Japan, Domestic conference当院におけるロボット支援下結腸切除術の導入 10例の経験Public symposium
- 日本消化器病学会近畿支部第119回例会, Japanese, 和歌山県立医科大学第二内科, 大阪, Japan, Domestic conferenceランチョンセミナー5 「進化する胃癌薬物治療~臨床データを踏まえた胃癌1次治療の選択ポイント~」Others
- 第39回兵庫大腸癌治療研究会, Japanese, 大鵬薬品工業株式会社・ミヤリサン製薬株式会社, Web, Japan, Domestic conference特別講演「大腸癌治療のUP TO DATE ~Well-beingを目指した新しい消化器外科教育を含めて~」Others
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceThe advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resectionOral presentation
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceEfficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancerOral presentation
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), English, The Korean Gastric Cancer Association, Seoul, Korea, Republic of, International conferenceNational Clinical Database in JapanPublic symposium
- 第2回~Anastomosis Master~, Japanese, ジョンソンエンドジョンソン株式会社, 神戸, Japan, Domestic conference講師Public discourse
- 第1回 Hanshin-GI, Japanese, 大鵬薬品工業株式会社, 大阪/Web, Japan, Domestic conference開会の挨拶Others
- 食道がん1次治療承認1周年記念講演会, Japanese, ブリストルマイヤーズスクイブ株式会社・小野薬品工業株式会社, 大阪/Web, Japan, Domestic conference2レジメンの特徴を踏まえた、食道がん1次治療におけるこれからの治療戦略Others
- Oncology&漢方 Hybrid Seminar, Japanese, 株式会社ツムラ, 大阪/Web, Japan, Domestic conferenceがん診療における漢方の役割Others
- Gastric Cancer Web Seminar, Japanese, 第一三共株式会社, 神戸/Web, Japan, Domestic conferenceHER2陽性胃癌の治療戦略Others
- 第3回神戸ラパロ道場, Japanese, コヴィディエンジャパン株式会社, 神戸, Japan, Domestic conference総合司会Others
- 第33回日本サイトメトリー学会学術集会, Japanese, 杏林大学大学院医学研究科 共同研究施設フロ−サイトメトリ−部門, Web, Japan, Domestic conference深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索Poster presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference日本消化器外科学会のデータベース (DB) 事業の取り組みOthers
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference術前補助療法後に原発巣 CR を達成した症例の予後因子解析; 多施設後ろ向き観察研究Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference年齢と術前化学療法レジメンが術後合併症発生例の予後悪化に及ぼす影響 -85 施設による多施設共同研究Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference消化器外科学会の挑戦~真の男女共同参画への道のりとマイルストーン~Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference日本における男性外科医と女性外科医の手術修練格差Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference直腸癌の術前化学放射線療法への抵抗性における Wnt/β-catenin シグナル活性化の重要性Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢胃癌患者への内視鏡治療後非治癒切除症例における予後因子の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference当院における TaTME 併用大腸全摘術の手術成績の検討Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference術中診断にて漿膜浸潤以上の深達度であった進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討Public symposium
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference当院における進行胃癌に対するロボット支援下胃切除術の短期治療成績の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference日本胃癌学会の NCD 利活用Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference特別企画6 【データベース委員会】NCD研究の現状と展望Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceASA 分類 Class 3 以上の大腸癌患者に対する腹腔鏡手術と開腹手術の比較検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢者食道癌患者に対する胸腔鏡下食道切除術Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference短期・長期成績からみた下部直腸癌に対するTaTME の有用性についてOral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference高齢者に対する胸腔鏡下食道切除後の経腸栄養は sarcopenia を予防できるか?Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceパネルディスカッション 3 【上部】【 Challenges beyond borders 】高度進行胃癌に対する conversion surgery の現状と新たな治療戦略Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座・小野薬品工業株式会社・ブリストルマイヤーズスクイブ株式会社, 函館, Japan, Domestic conferenceランチョンセミナー15 実践!胃癌一次治療におけるオプジーボ併用療法のエビデンスと臨床への活かし方Others
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference鼠経転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conference十二指腸浸潤を伴う胃癌に対する胃切除術の安全性の検討Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceロボット支援下食道切除術の術者育成Oral presentation
- 第78回日本消化器外科学会総会, Japanese, 弘前大学大学院医学研究科消化器外科学講座, 函館, Japan, Domestic conferenceAI 組織診断を用いた術前化学放射線療法後直腸癌の腫瘍 CD8+T 細胞の評価法の開発とその応用Oral presentation
- 第23回千葉消化管運動機能研究会, Japanese, 千葉消化管運動機能研究会・株式会社ツムラ, 千葉/Web, Japan, Domestic conference作用機序からみた漢方と消化管治療Others
- 第99回大腸癌研究会学術集会, Japanese, 関西労災病院 外科, 尼崎, Japan, Domestic conference下部直腸癌に対するTaTMEの有用性とラーニングカーブOral presentation
- 第29回日本ヘリコバクター学会学術集会, Japanese, 杏林大学医学部感染症学教室, 東京/Web, Japan, Domestic conference日本胃癌学会合同企画シンポジウム 胃癌の最新トピックス~ピロリ菌感染診断、未感染胃癌、治療法の進歩Others
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference高齢者に対する腹臥位胸腔鏡下食道切除術Poster presentation
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference全周性かつ表層拡大食道癌症例の特徴と手術治療成績Poster presentation
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference高齢者食道癌における術前化学療法、術後合併症の予後への影響Public symposium
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference食道胃接合部癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性Public symposium
- 第77回日本食道学会学術集会, Japanese, 近畿大学医学部 外科学教室上部消化管部門, 大阪, Japan, Domestic conference短期・長期成績からみたロボット支援食道切除術のエビデンスPublic symposium
- オプジーボ胃癌Web Liveセミナー, Japanese, 小野薬品工業株式会社・ブリストルマイヤーズスクイブ株式会社, Web, Japan, Domestic conferenceMOAから考える長期生存効果の意義Others
- 第11回若手消化器外科腹腔鏡セミナー, Japanese, 神戸大学大学院医学研究科外科学講座 食道胃腸外科学分野・肝胆膵外科学分野, 神戸, Japan, Domestic conference閉会の挨拶Others
- 第44回癌免疫外科研究会, Japanese, 千葉大学大学院医学研究院 先端応用外科, 千葉, Japan, Domestic conference大腸癌腫瘍免疫微小環境におけるCD4+T細胞に与える肥満の影響Oral presentation
- 第44回癌免疫外科研究会, Japanese, 千葉大学大学院医学研究院 先端応用外科, 千葉, Japan, Domestic conference化学放射線治療による腫瘍微小環境の変化~深層学習に基づくイメージサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索~Oral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceNeutrophil lymphocyte ratio and histological response correlate with prognosis of gastric cancer undergoing neoadjuvant chemotherapyOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceLuncheon Seminar 11 : Proximal gastrectomy: For better postoperative functionOthers
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferencePractical use of National Clinical Database in gastric cancer treatmentOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceTranslational 1 : Artificial intelligence in the management of gastric cancerOthers
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceSafety of laparoscopic gastrectomy for advanced gastric cancer with greater than serosal invasion depthOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceThe prognostic factors of early gastric cancer in elderly patients after non-curative endoscopic resectionOral presentation
- The 15th International Gastric Cancer Congress (IGCC 2023), English, Department of Surgery, Keio University School of Medicine, Yokohama, Japan, Domestic conferenceSurgical outcomes of elderly patients with Stage I gastric cancer from the nationwide registry of the Japanese Gastric Cancer AssociationOthers
- 第193回兵庫県外科医会学術集会, Japanese, 兵庫県外科医会, 神戸, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Oral presentation
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference高齢者食道癌患者に対する胸腔鏡下食道切除術Public symposium
- 第66回関西胸部外科学会学術集会, Japanese, JCHO大阪病院, 大阪, Japan, Domestic conference進行食道癌に対するロボット支援下食道切除Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科・日本イーライリリー株式会社, 横浜, Japan, Domestic conferenceランチョンセミナー5 「切除不能進行・再発胃癌に対する化学療法」Others
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference食道切除 ・ 胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチPoster presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conferenceThe mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT.Oral presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討Oral presentation
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference大量の難治性乳び腹水を伴う直腸間膜リンパ管嚢腫破裂に対して手術加療を施行した 1 例Others
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference当院における TaTME 併用による大腸全摘術、 回腸嚢肛門吻合術の手術成績Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference高齢胃癌患者の内視鏡治療後非治癒切除症例における予後因子の検討Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference血行再建を伴う胸壁前有茎空腸再建術の有用性Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference膵臓側に位置する表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の工夫Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conference自律神経を意識した腹臥位胸腔鏡下食道切除術Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conferenceNACRT 後の直腸癌の腫瘍微小環境の変化~ AI を用いた新規予後因子の探索~Public symposium
- 第48回日本外科系連合学会学術集会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, Japan, Domestic conferenceシンポジウム 3 「癌治療における術前術後集学的治療の現状と成績」Others
- 第32回日本癌病態治療研究会, Japanese, 自治医科大学, さいたま, Japan, Domestic conference症例報告セッションOthers
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, Japan, Domestic conference一般演題 「胃 5」Others
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, Japan, Domestic conference鼠径部転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績Oral presentation
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科・ミヤリサン製薬株式会社, 東京, Japan, Domestic conference消化器癌と腸内細菌Public discourse
- 第45回日本癌局所療法研究会, Japanese, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, Japan, Domestic conference直腸癌の術前化学放射線療法への抵抗性における Wnt/ β -catenin シグナル活性化の重要性Oral presentation
- 食道癌オプジーボWEBライブセミナー, Japanese, ブリストルマイヤーズスクイブ株式会社・小野薬品工業株式会社, 神戸, Japan, Domestic conference兵庫県エリアセミナー:症例ディスカッション 食道がん1次治療におけるレジメン選択Others
- 第21回日本ヘルニア学会学術集会, Japanese, 大阪府済生会吹田病院へルニアセンター, 大阪, Japan, Domestic conference【賛助講演】 鼠径部ヘルニアの新NCD登録に対する要望と今後の日本ヘルニア学会に期待することPublic symposium
- 第21回日本ヘルニア学会学術集会, Japanese, 大阪府済生会吹田病院へルニアセンター, 大阪, Japan, Domestic conference当科における全身合併症を伴う鼠径部ヘルニア手術の周術期管理の安全性の検討Public symposium
- 第5回サージカルフォーラム in Fukui, Japanese, 科研製薬株式会社, 福井, Japan, Domestic conference胃癌の集学的治療戦略Others
- 第10回平成大腸癌カンファレンス, Japanese, 中外製薬株式会社, 神戸, Japan, Domestic conferenceSession2 ゲノム医療で変わる?大腸癌薬物療法Others
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Public symposium
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference当院における経肛門的アプローチ併用による大腸全摘出の手術手技Public symposium
- 第77回手術手技研究会, Japanese, 愛知医科大学 消化器外科, 名古屋, Japan, Domestic conference当院におけるロボット支援下胃切除術のメインデバイスの変遷Public symposium
- 第38回日本臨床栄養代謝学会学術集会, Japanese, 神戸大学大学院医学研究科 外科系講座 災害・救急医学分野・旭化成ファーマ株式会社, 神戸/Web, Japan, Domestic conference学術セミナー14 救急医療におけるチームマネジメントOthers
- 第38回日本臨床栄養代謝学会学術集会, Japanese, 神戸大学大学院医学研究科 外科系講座 災害・救急医学分野, 神戸/Web, Japan, Domestic conference教育講演9 重症患者に対する栄養療法 その患者さんにタンパク制限はNGです!Others
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科・消化器外科女性医師の活躍を応援する会, 東京, Japan, Domestic conference外科学会における働き方改革の取り組みOthers
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference貧血が直腸癌低位前方切除術後合併症に与える影響Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference外科医獲得にむけた外科学講座全体での取り組みOthers
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference外科医で女性で子持ちで研究者は四重苦? Physician scientist として「外科的治療だけでは難しい癌」を外科医が研究する意義Others
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceオープンソースの物体検出アルゴリズム YOLOv3 を用いた胸腔鏡下食道亜全摘術の手術動画解析Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference知っておきたい外科学の最新トピックス 8 胃癌外科治療の最新トピックスOthers
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績Poster presentation
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference食道切除後長期の腸瘻での栄養管理はサルコペニアを予防するPublic symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceAI 病理診断システムを用いた直腸癌の新規予後因子の探索Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference局所進行直腸癌術前療法における腫瘍内レジデントメモリー CD8+T 細胞の動態とその役割Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferenceDiversity からさらに未来へ~Diversity だけで十分ですか? ~Others
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference特別企画 2 女性外科医コンセプトから,より包括的ダイバーシティ推進へOthers
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference経肛門アプローチによる側方郭清の標準化手術手技と手術成績Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科・日本イーライリリー株式会社, 東京, Japan, Domestic conferenceランチョンセミナー(2) 胃癌・食道胃接合部癌に対する集学的治療の Best PracticeOthers
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference食道胃接合部癌に対する経裂孔的腹腔鏡下 y 字型食道胃管吻合の有用性Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conference当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討Public symposium
- 第123回日本外科学会定期学術集会, Japanese, 東京慈恵会医科大学 外科学講座 血管外科, 東京, Japan, Domestic conferencecStageIV 胃癌の conversion surgery における周術期化学療法の検討Public symposium
- 食道がんオプジーボWEBライブセミナー-周術期から進行・再発まで-, Japanese, 小野薬品工業株式会社・ブリストルマイヤーズスクイブ株式会社, Web, Japan, Domestic conference進行・再発食道がん1次治療におけるオプジーボベースレジメンの特徴と位置づけOthers
- 食道がんオプジーボWEBライブセミナー-周術期から進行・再発まで-, Japanese, 小野薬品工業株式会社・ブリストルマイヤーズスクイブ株式会社, Web, Japan, Domestic conference食道がん周術期におけるICIを用いた治療戦略Others
- 第38回兵庫大腸癌治療研究会, Japanese, ミヤリサン製薬株式会社・大鵬薬品工業株式会社, Web, Japan, Domestic conference特別講演 「大腸がん治療における最新のエビデンスと今後の展望」Others
- Gastric Cancer Update Seminar, Japanese, ブリストルマイヤーズスクイブ株式会社・小野薬品工業株式会社, Web, Japan, Domestic conference特別講演 胃癌一次治療のベストプラクティス~最新情報と治療戦略~Others
- Upper GI WEB ライブセミナー, Japanese, 小野薬品工業株式会社・ブリストルマイヤーズススクイブ株式会社, Web, Japan, Domestic conferenceSession 2:胃癌パート 長期フォローアップから見えてきたオプジーボ併用化学療法の真価Others
- 上部消化管内視鏡手術セミナー, Japanese, オリンパスマーケティング株式会社, Web, Japan, Domestic conference閉会挨拶Others
- 上部消化管内視鏡手術セミナー, Japanese, オリンパスマーケティング株式会社, Web, Japan, Domestic conference座長Others
- 上部消化管内視鏡手術セミナー, Japanese, オリンパスマーケティング株式会社, Web, Japan, Domestic conference開会挨拶Others
- 神戸消化器外科手術手技セミナー, Japanese, テルモ株式会社, 神戸/Web, Japan, Domestic conference特別講演 当院におけるロボット手術の教育と取り組みOthers
- 第2回兵庫胃ビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, 神戸, Japan, Domestic conference司会Others
- 甲信がん Total Care Web Seminar, Japanese, 第一三共株式会社, Web, Japan, Domestic conference胃癌治療戦略2023Oral presentation
- TSUMURA Surgery SEMINAR, Japanese, 株式会社ツムラ, Web, Japan, Domestic conferenceがん診療における漢方の役割Others
- 第95回日本胃癌学会総会, English, 静岡県立静岡がんセンター内視鏡科, Sapporo, Japan, Domestic conferenceWorkshop2 Establishment of postoperative QOL evaluation method for gastric cancerOthers
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference残胃進行癌(幽門側胃切除後)の至適リンパ節郭清範囲Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference高齢の胃癌患者に対する術前化学療法の安全性の検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference当院におけるCY1を伴う進行胃癌に対する集学的治療戦略Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference胃癌切除例におけるpoorly cohesive carcinomaの臨床病理学的特徴と予後に関する検討Public symposium
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference新規半消化態栄養剤を用いた胃癌術後経口栄養療法の安全性に関する検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference腹腔鏡下経裂孔アプローチにおける左横隔膜開放法による下縦隔郭清・再建の安全性に関する検討Poster presentation
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科・第一三共株式会社, 札幌, Japan, Domestic conferenceランチョンセミナー7 HER2陽性胃癌の最適な治療シークエンスを考えるOthers
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科・大鵬薬品工業株式会社, 札幌, Japan, Domestic conferenceランチョンセミナー3Others
- 第95回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター内視鏡科, 札幌, Japan, Domestic conference胃癌学会の進路Others
- 第55回制癌剤適応研究会, Japanese, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, Japan, Domestic conferenceStageIV胃癌のconversion surgeryにおける周術期化学療法と予後の検討Public symposium
- 第55回制癌剤適応研究会, Japanese, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, Japan, Domestic conference放射線治療による腫瘍微小環境の変化~ AI組織解析システムを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索~Public symposium
- 第55回制癌剤適応研究会, Japanese, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, Japan, Domestic conferenceシンポジウム3-3 Conversion surgery;適応のエビデンスとは? 消化管Others
- 守口門真漢方実践 病診薬連携セミナー, Japanese, 株式会社ツムラ, 守口, Japan, Domestic conference漢方を使う消化管集学的治療Others
- The 18th Annual Academic Surgical Congress, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, United States, Domestic conferenceThe mGPS is a significant oncological marker of rectal cancer patients undergoing NACRTOral presentation
- The 18th Annual Academic Surgical Congress, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, United States, Domestic conferenceRisk factor for stricture after cervical triangular anastomosis in Minimally Invasive EsophagectomyOthers
- 第19回日本消化管学会総会学術集会, Japanese, 日本医科大学消化器内科学・日本医科大学付属病院消化器・肝臓内科, 東京, Japan, Domestic conference胃癌・食道胃接合部癌の術前化学療法効果診断における組織学的効果判定および宿主免疫指標マーカーの有用性の検討Public symposium
- 第19回日本消化管学会総会学術集会, Japanese, 日本医科大学消化器内科学・日本医科大学付属病院消化器・肝臓内科, 東京, Japan, Domestic conferenceコアシンポジウム2 消化管腫瘍の新展開 【治療効果の診断と治療法選択】Others
- 第98回大腸癌研究会学術集会, Japanese, 順天堂大学大学院医学研究科・人体病理病態学, 東京, Japan, Domestic conference当院における若年者大腸癌手術症例の検討Poster presentation
- 日本消化器病学会近畿支部第118回例会, Japanese, 京都府立医科大学大学院医学研究科消化器外科学・日本イーライリリー株式会社, 京都, Japan, Domestic conference胃癌治療戦略2023Others
- 日本消化器病学会近畿支部第118回例会, Japanese, 京都府立医科大学大学院医学研究科消化器外科学, 京都, Japan, Domestic conference食道胃接合部腺癌に対する当科の治療戦略Public symposium
- エドルミズWEBライブセミナー, Japanese, 小野薬品工業株式会社, Web, Japan, Domestic conference気付いていますか?がん患者の体重減少Others
- Gastric Cancer Forum 2022, Japanese, 第一三共株式会社, 東京/Web, Japan, Domestic conferenceOpening RemarksOthers
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), English, Fujita Health University Hospital International Medical Center, Nagoya/web, Japan, Domestic conferenceHybrid abdominal robotic approach with TaTME for low rectal cancerPublic symposium
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), English, Fujita Health University Hospital International Medical Center, Nagoya/web, Japan, Domestic conferenceNovel “Modified Bascule method” for lymphadenectomy along the left recurrent laryngeal nerve during robot-assisted minimally invasive esophagectomyOral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference胸腔鏡下食道悪性腫瘍手術における術中体位が術後肺炎発症に与える影響;NCD データ 9850 例の解析からPublic symposium
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conferenceロボット支援下食道切除術の胸腔鏡手術と比較した短期成績:NCD 解析結果Public symposium
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference食道癌に対する腹臥位胸腔鏡下食道切除術の短期・長期成績Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference一般演題(口演) 48 上部 高齢者Others
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference腫瘍深達度が漿膜浸潤以上の進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference直腸癌に対する Abdominal robotic approach 併用による Hybrid TaTMEOral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conferenceTransanal アプローチ併用側方郭清の治療成績と安全に行うための工夫Oral presentation
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conference当科における残胃癌に対する腹腔鏡下残胃全摘術の手術成績と予後の検討Public symposium
- 第35回日本内視鏡外科学会総会, Japanese, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, Japan, Domestic conferenceロボット支援食道切除の短期成績 - 胸腔鏡手術との比較 -Public symposium
- 第26回日本バイオ治療法学会学術集会, Japanese, 徳島大学大学院社会産業理工学研究部生物資源産業学域, 大阪, Japan, Domestic conference切除不能Stage4 大腸癌におけるマイクロRNA-221 の発現意義Oral presentation
- 第26回日本バイオ治療法学会学術集会, Japanese, 徳島大学大学院社会産業理工学研究部生物資源産業学域, 大阪, Japan, Domestic conferenceAI 病理診断システムを用いた直腸癌の新規予後因子の探索Oral presentation
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, Japanese, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座(第二内科)・大分大学医学部 消化器・小児外科学講座, 那覇, Japan, Domestic conference肥満が大腸癌腫瘍微小環境のCD4陽性T細胞に及ぼす影響Oral presentation
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, Japanese, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座(第二内科)・大分大学医学部 消化器・小児外科学講座, 那覇, Japan, Domestic conferenceCOVID19 感染下における腹腔鏡下スリーブ状胃切除術の導入と短期治療成績Oral presentation
- 第35回日本バイオセラピィ学会学術集会総会, Japanese, 福島県立医科大学 消化管外科学講座, 福島, Japan, Domestic conference大腸癌の腫瘍免疫微小環境における CD4 陽性T細胞に与える肥満の影響Oral presentation
- 第35回日本バイオセラピィ学会学術集会総会, Japanese, 福島県立医科大学 消化管外科学講座, 福島, Japan, Domestic conference放射線治療における腫瘍内 CD8+T細胞の動態Public symposium
- 第35回日本バイオセラピィ学会学術集会総会, Japanese, 福島県立医科大学 消化管外科学講座, 福島, Japan, Domestic conferenceAI イメージサイトメトリーを用いた直腸癌術前化学放射線療法の腫瘍 CD8+T 細胞の新たな評価法の開発Public symposium
- 大腸癌化学療法の学術講演会「Leader's Meeting in Kansai&Tokyo」, Japanese, メルクバイオファーマ株式会社, 大阪, Japan, Domestic conferenceパネルディスカッション 大腸癌薬物療法~抗GFR抗体の最適利用~Others
- 第84回日本臨床外科学会総会, Japanese, 久留米大学医学部外科学講座, 福岡, Japan, Domestic conferenceパネルディスカッション04 食道癌手術における周術期チーム医療についてOthers
- 第84回日本臨床外科学会総会, Japanese, 久留米大学医学部外科学講座, 福岡, Japan, Domestic conference周術期チーム医療による腹臥位胸腔鏡下食道切除術Public symposium
- 胃癌一次治療1周年記念講演会 オプジーボ+化学療法, Japanese, ブリストルマイヤーズスクイブ株式会社・小野薬品工業株式会社, 福岡/Web, Japan, Domestic conference総合討論 臨床使用から出てくる疑問Others
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference残胃癌に対する腹腔鏡下残胃全摘術の手術成績の検討Public symposium
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference幽門側胃切除後の残胃内容排出遅延に関する検討Public symposium
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第52回胃外科・術後障害研究会, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津/Web, Japan, Domestic conference要望演題1-2 高齢者胃癌2Others
- 第6回胃癌周術期治療講演会, Japanese, 大鵬薬品工業株式会社, 大阪/Web, Japan, Domestic conference胃癌周術期治療戦略2022Public discourse
- 神戸消化器癌フォーラム2022@Web, Japanese, 日本化薬株式会社, Web, Japan, Domestic conference大腸癌に対する最新集学的治療 2022Others
- 第33回日本消化器癌発生学会総会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japan, Domestic conference大腸癌のおけるCD4陽性T細胞の抗腫瘍免疫に及ぼす肥満の影響Public symposium
- 第33回日本消化器癌発生学会総会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japan, Domestic conference放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態Public symposium
- 第33回日本消化器癌発生学会総会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japan, Domestic conferenceシンポジウム2 臨床応用を意識した消化器癌研究Others
- 第21回兵庫胃がん治療研究会, Japanese, 大鵬薬品工業株式会社, Web, Japan, Domestic conference閉会挨拶Others
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, English, Korean Surgical Society, Seoul, Korea, Republic of, Domestic conferenceLaparoscopic Endoscopic Cooperative Surgery Using Openwindow Suturing Technique for Treating Non-ampullary Superficial Duodenal Neoplasms Located on the Pancreatic SideOral presentation
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, English, Korean Surgical Society, Seoul, Korea, Republic of, Domestic conferenceComparison of Laparoscopic Gastrectomy for Gastric Cancer with 3D and 2D MonitorsPublic symposium
- 日本消化器病学会東海支部第137回例会, Japanese, 浜松医科大学第二外科・株式会社ツムラ, 浜松, Japan, Domestic conferenceランチョンセミナー①「集学的治療における漢方薬の役割」Oral presentation
- 第73回日本気管食道科学会総会, Japanese, 琉球大学 耳鼻咽喉・頭頸部外科学講座, 宜野湾, Japan, Domestic conferenceワークショップ2 気管食道科領域の画像・AI診断Others
- 第19回神戸消化器外科懇話会学術講演会, Japanese, 神戸消化器外科懇話会・株式会社大塚製薬工場, 神戸, Japan, Domestic conference特別講演ⅠOthers
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conference食道胃接合部に近接する胃消化管間質腫瘍に対する腹腔鏡下局所切除の安全性についての検討Poster presentation
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conferenceオープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析Poster presentation
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conference当院における食道胃接合部腺癌に対する治療戦略Public symposium
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conference下部直腸癌に対するTaTMEの手術成績~Lap-TMEとの比較~Public symposium
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conferenceパネルディスカッション8 食道胃接合部癌に対する集学的治療Others
- JDDW2022(第30回日本消化器関連学会週間), Japanese, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, Japan, Domestic conferenceこれまでに築かれてきた術後補助化学療法のエビデンスPublic symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference食道癌における術前 CF 療法に対する DCF 療法の有用性の検証 -85 施設 4048 例の検討Oral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference術前補助療法後の食道癌根治切除症例における再発予測ノモグラムの開発Others
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference全国がん登録の利活用に向けた学会研究体制の整備Public symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferenceコロナ禍が消化器がん医療にもたらしたものPublic symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferencecStageIV胃癌に対するconversion surgeryの手術成績と予後因子の検討Public symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference鼠経リンパ節転移を伴う直腸癌に対する術前治療と選択的鼠経郭清の臨床的意義Poster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference術前化学療法における Alb/ dNLR の推移は食道癌の予後に関与するかPoster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference直腸癌術前化学放射線療法の予後因子としての modified Glasgow Prognostic ScoreOral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conference直腸癌術前化学放射線療法における AI を用いた腫瘍組織 CD8+T 細胞の評価方法の検討Oral presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferenceFDG-PET/CTによる進行胃癌の病理学的病期の術前予測の有用性Poster presentation
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, Japan, Domestic conferenceNational Clinical Database の利活用とがん医療Public symposium
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野、ブリストル・マイヤーズスクイブ株式会社、小野薬品工業株式会社, 神戸/Web, Japan, Domestic conference学術セミナー38 胃癌1次治療オプジーボ+化学療法の特徴:CheckMate 649 長期フォローデータから読み解くOthers
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野、ミヤリサン製薬株式会社, 神戸/Web, Japan, Domestic conferenceイブニングセミナー3 食道癌・大腸癌の治療最前線Others
- 第60回日本癌治療学会学術集会, Japanese, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野、ブリストル・マイヤーズスクイブ株式会社, 神戸/Web, Japan, Domestic conference会長企画シンポジウム2 がん医療におけるAI-ここまで進んだ臨床応用-Others
- American College of Surgeons Clinical Congress 2022, English, American College of Surgeons, San Diego,CA, United States, Domestic conferenceEn-bloc Radical Lateral Pelvic Lymph Node Dissection Assisted By A Transanal ApproachPublic discourse
- Oncologyインターネット講演会 食道癌 専門医向け, Japanese, MSD株式会社, 大阪/Web, Japan, Domestic conference講演2 キイトルーダ+FP療法のマネジメント~外来投与のTips~Others
- Oncologyインターネット講演会 食道癌 専門医向け, Japanese, MSD株式会社, 大阪/Web, Japan, Domestic conference講演1 自験例から考える食道癌1次治療としてのキイトルーダ+FP療法の可能性~外科医の立場から~Others
- オプジーボワンポイントWEBレクチャー, Japanese, 小野薬品工業株式会社・ブリストルマイヤーズスクイブ株式会社, Web, Japan, Domestic conference講演「胃癌一次治療におけるオプジーボ併用療法の適正使用」Others
- 第44回日本臨床栄養学会総会・第43回日本臨床栄養協会総会・第20回大連合大会, Japanese, 岩手医科大学外科学講座・甲南女子大学医療栄養学部・ミヤリサン製薬株式会社, 盛岡, Japan, Domestic conferenceワークショップ2 高齢者の肥満とサルコペニア・フレイルOthers
- 第44回日本臨床栄養学会総会・第43回日本臨床栄養協会総会・第20回大連合大会, Japanese, 岩手医科大学外科学講座・甲南女子大学医療栄養学部・ミヤリサン製薬株式会社, 盛岡, Japan, Domestic conferenceランチョンセミナー6 腸内細菌のリテラシーOthers
- 第75回日本胸部外科学会定期学術集会, Japanese, 東京大学医学部附属病院 呼吸器外科, 横浜/Web, Japan, Domestic conference食道癌手術後の胃管癌の特性と重複癌の検討Oral presentation
- 第75回日本胸部外科学会定期学術集会, Japanese, 東京大学医学部附属病院 呼吸器外科, 横浜/Web, Japan, Domestic conference腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較(LAP vs HALS)Oral presentation
- UTSUKUSHIMA G・I SEMINAR 2022, Japanese, 大鵬薬品工業株式会社, 福島/Web, Japan, Domestic conference進化する胃癌治療2022Oral presentation
- 第23回神戸外科フォーラム, Japanese, 大鵬薬品工業株式会社, 神戸, Japan, Domestic conference閉会挨拶Others
- 第23回神戸外科フォーラム, Japanese, 大鵬薬品工業株式会社, 神戸, Japan, Domestic conference特別講演Ⅱ 「わが国の医療環境と今後の取り組み~胃癌・大腸癌の治療におけるロンサーフⓇの役割~」Others
- 日本消化器病学会東北支部 第24回教育講演会, Japanese, 株式会社ツムラ, Web, Japan, Domestic conferenceがん診療におけるKAMPOOthers
- 第81回日本癌学会学術集会, Japanese, 東京大学医科学研究所 人癌病因遺伝子分野, 横浜/Web, Japan, Domestic conferenceAnalyses of terminally differentiated normal cells guide the identification of cancer stem cell-suppressor microRNAs 正常最終分化細胞の解析によるがん幹細胞抑制性マイクロRNAの同定Others
- Kobe IBD Open Conference, Japanese, アッヴィ合同会社, 神戸/Web, Japan, Domestic conference閉会挨拶Others
- 18th ISDE World Congress for Esophageal Diseases, English, International Society for Diseases of the Esophagus, Web, Japan, Domestic conferenceComparison of Laparoscopic Surgeries With or Without Hand-Assisted Procedure in the Abdominal Phase of Thoracoscopic Esophagectomy in the Prone PositionPoster presentation
- 第42回分子腫瘍マーカー研究会, Japanese, 九州大学病院別府病院 外科, Web, Japan, Domestic conference胃癌の免疫療法におけるbiomarker確立の必要性Public symposium
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceNCDデータを用いた頸部食道癌手術における消化管再建臓器別の術後短期成績の検討Poster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference食道扁平上皮癌術前補助療法における治療前血清SCC抗原の意義Public symposium
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceロボット支援食道切除術の利点と課題Poster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceAlbumin-derived NLR score is a novel prognostic marker for esophageal squamous cell carcinomaPoster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference胸腔鏡下食道切除症例における栄養介入としての腸瘻チューブ留置期間の検討Poster presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較(LAP vs HALS)Oral presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conference低侵襲と合併症リスクの低減を目指した腹腔鏡下胸骨後経路作成の術後成績Oral presentation
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceビデオシンポジウム3 胸部食道癌手術における腹部操作HALS or LAPOthers
- 第76回日本食道学会学術集会, Japanese, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, Japan, Domestic conferenceシンポジウム7 食道癌・接合部癌 治療における免疫チェックポイント阻害剤の適切な患者選択は? CPS ? TPS ?Others
- ~Anastomosis Master~, Japanese, ジョンソン・エンド・ジョンソン株式会社, 神戸, Japan, Domestic conference講師Public discourse
- ONCOLOGY KAMPO SHORT LECTURE, Japanese, 株式会社ツムラ, Web, Japan, Domestic conferenceがん治療におけるKAMPOPublic discourse
- 第35回近畿内視鏡外科研究会, Japanese, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, Japan, Domestic conference当院における右側結腸癌に対する体腔内吻合の導入と治療成績Oral presentation
- International Surgical Week ISW 2022-World's Congress of Surgery, English, International Society of Surgery, Vienna, AustriaGASTRIC CANCER: CONTROVERSIES IN MANAGEMENT - EXTENT OF RESECTION, D1 VERSUS D2 LYMPH NODE DISSECTION, NEO-ADJUVANT AND ADJUVANT THERAPYPublic symposium
- 食道がん1次治療承認記念講演会~オプジーボ+ヤーボイとオプジーボ+化学療法~, Japanese, ブリストルマイヤーズ スクイブ株式会社/小野薬品工業株式会社, Web, JapanSession2 進行再発食道がん薬物療法のエビデンスPublic discourse
- Oncology&Kampo Web Seminar, Japanese, 府中病院・泉大津市立病院・株式会社ツムラ, Web, Japanがん診療における漢方の役割Public discourse
- ベクティビックス全国講演会, Japanese, 武田薬品工業株式会社, Web, Japan第一部 講演「原発巣占居部位による治療決定の歴史を振り返る」Public discourse
- 食道がん1次治療オプジーボ併用療法承認記念講演会in KOBE, Japanese, ブリストルマイヤーズ スクイブ株式会社・小野薬品工業株式会社, Web, Japan基調講演「食道がん手術の最前線」Public discourse
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanCDX2低発現大腸癌の腫瘍生物学的特徴の検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan術前サルコペニアの層別化による短期・長期リスク評価の有用性Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan80歳以上の大腸癌患者における腹腔鏡手術の有用性Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan下部直腸癌手術におけるTaTMEの有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan胃癌におけるFDG-PET検査によるリンパ節SUVmax値を用いたリンパ節転移診断の有用性の検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan抗凝固療法中の患者に対する胃切除術の安全性についてOral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan胸腔鏡下食道切除症例における腸瘻チューブ留置による栄養介入とその意義Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan当院における右側結腸癌に対する体腔内吻合の手術手技と短期成績Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapancStageⅣ胃癌に対するconversion surgeryの治療成績Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan胃癌大弯側リンパ節郭清時に周囲リンパ節の郭清ラインとの連続性を意識した#4sb郭清手技の有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan低肺機能患者に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan直腸悪性腫瘍に対するHybrid手術の短期成績に関する後ろ向き研究Oral presentation
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanSiewert II型食道胃接合部癌に対する偽His角・穹窿部を付加したy字様Overlap食道胃管吻合の有用性Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan頭側アプローチによる腹腔鏡下結腸右半切除~術者経験を考慮した段階的導入と定型化~Public symposium
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japanパネルディスカッション5 【下部】局所進行・再発大腸癌の手術適応に関するPrecision medicinePublic discourse
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japanランチョンセミナー4Public discourse
- 第77回日本消化器外科学会総会, Japanese, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, Japan特別企画2 夢を語ろう:スーパーエクステンデッドサージャリーと周術期管理のはざまPublic discourse
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanLaparoscopic retrosternal route creation for gastric conduit - efficacy and outcomes 腹腔鏡による胸骨後経路作成の工夫と術後成績Public symposium
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanDevelopment of a new method for evaluation of rectal cancer after neoadjuvant chemoradiotherapy 直腸癌術前化学放射線療法における腫瘍組織CD8+T細胞の新たな評価方法の開発Public symposium
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanA predictive nomogram model of therapeutic effect in neoadjuvant treatment for esophageal cancer 食道癌術前補助療法の奏効を予測するツールの開発;多施設共同後ろ向き観察研究Public symposium
- 第77回日本消化器外科学会総会, English, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, JapanThe multicenter validation study of NAC response and recurrence patterns for esophageal cancer 切除可能進行食道癌における術前化学療法の奏効と再発形式の検証 -85施設3995例による多施設共同研究-Public symposium
- 第2回神戸ラパロ道場, Japanese, コヴィディエンジャパン株式会社, Web, Japan閉会挨拶Public discourse
- 第2回神戸ラパロ道場, Japanese, コヴィディエンジャパン株式会社, Web, Japan総合司会Public discourse
- 消化器癌治療フォーラム, Japanese, MSD株式会社, Web, Japanガイドライン改訂を踏まえた大腸癌治療2022Public discourse
- 第31回日本がん転移学会学術集会・総会, Japanese, 京都大学医学研究科, 京都/Web, Japan大腸癌腹膜播種モデルでは、PMN-MDSCが病態を進行させるPoster presentation
- 第97回大腸癌研究会学術集会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科, 東京/Web, Japan閉塞性大腸癌患者に対する腹腔鏡下手術の術前自己拡張型金属ステントの有用性Oral presentation
- 第44回日本癌局所療法研究会, Japanese, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, Japan遠隔転移を有するHER2陽性進行胃癌に対しConversion Surgeryを施行し奏効を得た1例Oral presentation
- 第44回日本癌局所療法研究会, Japanese, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, Japan食道癌に対するESD後の良性狭窄に対し食道バイパス手術によりQOL向上を得られた一例Oral presentation
- 第44回日本癌局所療法研究会, Japanese, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, Japan主題 4「QOL向上や症状緩和をめざした局所療法」Public discourse
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan術前化学療法における Alb-dNLR ratioの推移は食道癌の予後に関与するかPoster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響Poster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan放射線治療における腫瘍内 CD8+T 細胞の動態Public symposium
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, JapancStageIV胃癌に対するconversion surgeryの予後の検討Poster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japan低侵襲治療を目指したロボット支援下胃切除術の導入と短期治療成績Poster presentation
- 第31回日本癌病態治療研究会, Japanese, 徳島大学消化器 移植外科学, 鳴門/Web, Japanコーヒーブレイクセミナー1 大腸がん薬物療法 2022 ~一次治療がすべてをきめる~Public discourse
- 第16回壬生Oncologyセミナー, Japanese, 中外製薬株式会社, 栃木/Web, Japan胃癌集学的治療戦略2022Invited oral presentation
- 日本消化器病学会近畿支部第69回教育講演会, Japanese, 神戸大学大学院医学研究科外科学講座肝胆膵外科学分野, 神戸, Japan講演5「炎症性腸疾患の内科的治療の進歩と外科治療の変遷」Public discourse
- 日本消化器病学会近畿支部第69回教育講演会, Japanese, 神戸大学大学院医学研究科外科学講座肝胆膵外科学分野, 神戸, Japan講演4「エビデンスに基づく食道癌の集学的治療」Public discourse
- 第65回関西胸部外科学会学術集会, Japanese, 浜松医科大学 外科学第一講座, 浜松, Japan食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチPublic symposium
- AOS 2022(2nd International Congress of ASIAN ONCOLOGY SOCIETY), English, Asian Oncology Society, Seoul/Web, Korea, Republic ofThoracic cavity-to-cage ratio is a predictor of technical difficulties in minimally invasive esophagectomyOral presentation
- 第47回日本外科系連合学会学術集会, Japanese, 岩手医科大学医学部外科学講座, 盛岡/Web, Japanジョイントセッション:日本外科系連合学会:環太平洋外科系学会日本支部会 1 Wada Award Session (English)1Public discourse
- 第47回日本外科系連合学会学術集会, Japanese, 岩手医科大学医学部外科学講座, 盛岡/Web, JapanNCDデータを利活用した外科治療への還元Invited oral presentation
- エドルミズWEBライブセミナー, Japanese, 小野薬品工業株式会社, Web, Japan実臨床におけるエドルミズ導入のポイントPublic discourse
- 食道癌治療セミナーin奈良, Japanese, MSD株式会社, 橿原市/Web, Japan食道癌に対する集学的治療2022Public discourse
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan腫瘍抗原導入樹状細胞にiNKT細胞リガンドを付加したワクチンは、抗原特異的な抗腫瘍免疫を効果的に誘導するPublic symposium
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan大腸癌の腫瘍免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響Public symposium
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan放射線治療における腫瘍内CD8+T細胞の動態Public symposium
- 第43回癌免疫外科研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, Japan【主題1-1】新規免疫療法への戦略とエビデンス1Public discourse
- 第76回手術手技研究会, Japanese, 佐賀大学医学部 一般・消化器外科, 佐賀/Web, Japan腹腔鏡による胸骨後経路作成の工夫と短期成績Public symposium
- 第76回手術手技研究会, Japanese, 佐賀大学医学部 一般・消化器外科, 佐賀/Web, JapanSF-20 胃4Public discourse
- オプジーボWEBライブセミナー~初夏のGC Week~, Japanese, 小野薬品工業株式会社・ブリストル・マイヤーズ スクイブ株式会社, Web, Japan講演「長期生存を目指した胃癌薬物療法~ニボルマブの登場で一次治療はどう変わるのか?~」Public discourse
- 兵庫プロバイオティクス学術セミナー, Japanese, ミヤリサン製薬株式会社, Web, Japan胃癌の集学的治療2022Oral presentation
- 第9回平成大腸癌カンファレンス, Japanese, 中外製薬株式会社, Web, JapanSesson2「ゲノム医療で変わる!大腸癌薬物療法について」Public discourse
- 第36回兵庫大腸癌治療研究会, Japanese, ミヤリサン製薬株式会社、大鵬薬品工業株式会社, Web, Japan特別講演「大腸癌治療ガイドラインUpDateバイオマーカーを考慮した治療戦略」Public discourse
- 手術手技と漢方を学ぶ会in愛知, Japanese, 株式会社ツムラ, 名古屋/Web, Japan集学的治療と漢方の役割Public discourse
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan高齢者の外科医療品質向上に向けた高齢者リスクモデルの構築Invited oral presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan肝胆膵領域におけるNCDデータ解析研究とACS-NSQIPから学ぶ外科医療成績向上へのステップInvited oral presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japanリアルワールドにおけるロボット支援下食道切除術の安全性と有効性:National Clinical Databaseによる分析Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan外科医獲得にむけた神戸大学外科学講座の取り組みInvited oral presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan術前化学療法におけるAlb/dNLRの推移は食道癌の予後に関与するかPublic symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan術前欠損歯数が胃癌予後に及ぼす影響についての検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japanサルコペニアの層別化によるリスク評価の有用性Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, JapanMIE施行症例における術前血小板リンパ球比の予後予測因子としての有用性Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan当科における下部進行直腸癌に対する治療戦略Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan高齢胃癌患者への内視鏡治療後非治癒切除症例における予後の検討Poster presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan胃・食道胃接合部癌術前化学療法における予後予測因子の検討Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan2チームによるTaTMEは狭骨盤や肥満による腹腔鏡下直腸癌手術の困難さを緩和するPublic discourse
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan直腸癌術前化学放射線療法における腫瘍内レジデントメモリーCD8+T細胞の動態とその予後Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan下部直腸癌に対するTaTMEと融合させたRobotic surgeryPublic symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japanロボット支援食道切除におけるlearning curveと手技の工夫Public symposium
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japan消化管領域におけるNCD研究の利活用Invited oral presentation
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japanパネルディスカッション09 「進行胃癌に対する集学的治療の現状と展望」Public discourse
- 第122回日本外科学会定期学術集会, Japanese, 熊本大学大学院 消化器外科学, 熊本市/Web, Japanランチョンセミナー(7) フッ化ピリミジン系抗癌剤をサイエンスするPublic discourse
- AACR ANNUAL MEETING 2022, English, American Association for Cancer Research, New Orleans/Web, United StatesPolymorphonuclear myeloid-derived suppressor cells reflect the status of peritoneal dissemination in colon cancer mouse modelPoster presentation
- 第14回消化器がん化学療法研究会, Japanese, 大鵬薬品工業株式会社, Web, Japan胃癌集学的治療戦略2022Invited oral presentation
- 神戸消化器がんセミナー, Japanese, 中外製薬株式会社, Web, JapanClosing RemarksPublic discourse
- 神戸消化器がんセミナー, Japanese, 中外製薬株式会社, Web, JapanSessionⅡ 「胃癌に対する外科手術の現況と展望」Public discourse
- 第30回近畿内視鏡下大腸手術研究会, Japanese, 近畿内視鏡下大腸手術研究会、株式会社ツムラ, 大阪/Web, Japan特別講演Ⅰ「横行結腸癌の腹腔鏡手術について」Public discourse
- ベクティビックス全国Web講演会, Japanese, 武田薬品工業株式会社, Web, JapanEBMに基づく抗EGFR抗体薬のリチャレンジ治療Public discourse
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討Public symposium
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japan抗血栓療法中の患者に対する胃癌手術の安全性の検討Poster presentation
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japanda Vinci Harmonicによるロボット支援下幽門側胃切除術の時間短縮効果と短期治療成績の検討Oral presentation
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japanイブニングセミナー3 HER2 陽性胃がんに対する薬物治療展開~エンハーツで繋ぐ~Public discourse
- 第94回日本胃癌学会総会, Japanese, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, Japanランチョンセミナー9 胃癌薬物療法における最新の知見Public discourse
- 第94回日本胃癌学会総会, English, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, JapanPhase Ⅱ study of neoadjuvant chemotherapy for locally advanced gastric cancer in elderly patientsPublic symposium
- 第94回日本胃癌学会総会, English, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, JapanThe Signicance of Surgical Intervention Following Chemotherapy for Stage IV Gastric CancerOral presentation
- 第94回日本胃癌学会総会, English, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, JapanSafety management of laparoscopic endoscopic cooperative surgery for duodenal tumorPublic symposium
- 第94回日本胃癌学会総会, English, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, JapanPanel Discussion 2 New development for HER2 positive advanced gastric cancerPublic discourse
- 第14回日本ロボット外科学会学術集会, Japanese, 鹿児島大学医学部産科婦人科, Web, Japanロボット支援食道切除における反回神経麻痺低減の試みPublic symposium
- 第14回日本ロボット外科学会学術集会, Japanese, 鹿児島大学医学部産科婦人科, Web, Japan一般口演25 胃③Public discourse
- 第14回日本ロボット外科学会学術集会, Japanese, 鹿児島大学医学部産科婦人科, Web, Japan領域別シンポジウム9【小児・開発】Public discourse
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan癌幹細胞マーカーは食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるPublic symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan大腸癌腹膜播種モデルにおける骨髄由来免疫抑制細胞の機能Public symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, Japan術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義Public symposium
- 第54回制癌剤適応研究会, Japanese, 富山大学消化器・腫瘍・総合外科/日本イーライリリー株式会社, Web/誌上開催, Japan特別講演1 Society 5.0における大腸癌治療成績向上への取り組み〜multidisciplinary treatmentの発展:West meets East〜Public discourse
- ベクティビックス全国Web講演会, Japanese, 武田薬品工業株式会社, Web, Japan進行再発大腸癌の個別化医療の展望Public discourse
- 第18回日本消化管学会総会学術集会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japan癌関連線維芽細胞および癌細胞で発現する Metallothionein 2A は食道扁平上皮癌の進展に関与するPublic symposium
- 第18回日本消化管学会総会学術集会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japanマクロファージとの相互作用により発現誘導される S100A8/A9 は Akt、p38 を介して食道扁平上皮癌細胞の運動能、浸潤能を亢進させるPublic symposium
- 第18回日本消化管学会総会学術集会, Japanese, 東京大学大学院医学系研究科消化管外科学, 東京/Web, Japanコアシンポジウム2 消化管腫瘍の新展開【分子レベルから展開する診断・治療戦略】Public discourse
- 兵庫ヘルニアビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, Web, Japan閉会の挨拶Public discourse
- 兵庫ヘルニアビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, Web, Japan開会の挨拶Public discourse
- 兵庫ヘルニアビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, Web, Japan総合司会Public discourse
- 17th Annual Acasemic Surgical Congress, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Florida/Web, United StatesAssessing The Risk Factors for Delayed Gastric Emptying after Distal Gastrectomy for Gastric CancerOral presentation
- Fushimi Surgery Kampo Seminar, Japanese, 株式会社ツムラ, Web, Japan消化器外科領域における漢方薬の役割~大建中湯・六君子湯・半夏瀉心湯~Invited oral presentation
- 胃癌一次治療適応追加記念講演会~ A New Breath in Gastric Cancer~, Japanese, ブリストル・マイヤーズスクイブ株式会社, Web, JapanOpening RemarksPublic discourse
- 第1回兵庫胃ビデオカンファレンス, Japanese, コヴィディエンジャパン株式会社, Web, Japan総合司会Public discourse
- 第96回大腸癌研究会, Japanese, 帝京大学医学部外科学講座, 東京/Web, Japan当科における経肛門アプローチ併用による側方リンパ節郭清の手術成績Oral presentation
- 第22回神戸外科WEBフォーラム 食道胃腸領域, Japanese特別講演「胃癌・食道癌における集学的外科治療」Public discourse
- 第190回兵庫県外科医会学術集会, Web開催/神戸, Domestic conference特別講演「低侵襲胃癌手術をより解像度を高めて考える」Others
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conferenceCRT後の難治性食道狭窄に対する鏡視下食道バイパス術 (Postlethwait 法) の試みOral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference脾弯曲部癌におけるリンパ節転移領域と頻度に関する多施設共同コホート試験 (SP study)Public symposium
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conferenceNCDを利用したロボット支援下胃切除の安全性・有効性に関する検討Public symposium
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference低肺機能に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conferenceロボット支援食道切除術においてenergy deviceが短期成績に及ぼす影響Public symposium
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference左結腸動脈処理に着目した腹腔鏡下左側結腸癌手術Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference当院における右側結腸癌に対する体腔内吻合の導入と治療成績Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference腹腔鏡下胃切除症例における周術期抗血栓療法の安全性の検討Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference当院におけるロボット支援下幽門側胃切除術の手技定型化の確立と短期治療成績Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conferenceロボット支援食道手術による反回神経麻痺の軽減に関する試みOral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference直腸悪性腫瘍に対するHybird abdominal robotic approach with conventional TaTMEの導入Public symposium
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conference直腸癌手術におけるTransanal minimally invasive ISRの有用性と課題Oral presentation
- 第34回日本内視鏡外科学会総会, Web開催/神戸, Domestic conferenceロボット支援食道切除における至適剥離層Public symposium
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference癌間質および癌細胞で発現するMT2Aは食道扁平上皮癌の進展に関与するPoster presentation
- Web開催, Domestic conference腫瘍関連マクロファージ由来のCCL1はCCR8に作用し、Akt/PRAS40/mTORシグナルを介して食道扁平上皮癌の進展に寄与するInvited oral presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference直腸癌に対するAbdominal robotic approach併用によるHybrid TaTMEPoster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference大腸癌術後の早期再発のリスク因子Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference癌幹細胞マーカーは、食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるPoster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference腫瘍抗原導入樹状細胞にα-GalCerを付加したワクチンベクターの抗腫瘍効果Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conference当科におけるStageⅣ胃癌に対するconversion surgeryの治療成績Poster presentation
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, Web開催, Domestic conferenceシンポジウム1 Innovation in Clinical Technology and Basic ScienceOthers
- 第30回日本コンピュータ外科学会大会, Web開催/つくば, Domestic conference胸腔鏡下食道切除術における3D内視鏡システムは術後短期成績の改善に寄与するOral presentation
- 第30回日本コンピュータ外科学会大会, Web開催/つくば, Domestic conferenceロボット支援食道切除手術におけるlearning curveOral presentation
- 第30回日本コンピュータ外科学会大会, Web開催/つくば, Domestic conference3D/HDおよび2D/4Kモニターが術者技術レベルごとの手術操作にもたらす影響Oral presentation
- 第30回日本コンピュータ外科学会大会, Web開催/つくば, Domestic conference3D‒CT を用いた骨盤計測と直腸癌手術時間との関連―通常の腹腔鏡下手術と Transanal Total Mesorectal Excision との違い―Oral presentation
- 第72回日本気管食道科学会総会ならびに学術講演会, Web開催, Domestic conferenceレチノイン酸レセプターγはヒトiPS細胞から食道上皮への分化誘導を促進するPublic symposium
- 第72回日本気管食道科学会総会ならびに学術講演会, Web開催, Domestic conferenceオープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析Public symposium
- 第72回日本気管食道科学会総会ならびに学術講演会, Web開催, Domestic conference胸腔鏡下食道切除術における嚥下性肺炎の予防Public symposium
- 第72回日本気管食道科学会総会ならびに学術講演会, Web開催, Domestic conferenceワークショップ2 人工知能・ビックデータを用いた研究Others
- 第51回胃外科・術後障害研究会, Web開催, Domestic conference幽門側胃切除後の残胃内容排出遅延に関する検討Oral presentation
- 第51回胃外科・術後障害研究会, Web開催, Domestic conference高齢者胃癌術後の肺炎併発が長期予後へ与える影響の検討Oral presentation
- 第51回胃外科・術後障害研究会, Web開催, Domestic conference要望演題4 高齢者胃癌手術-2Others
- JDDW2021(第29回日本消化器関連学会週間), Web開催/神戸, Domestic conference術中重大出血・周術期輸血量からみた急性汎発性腹膜炎手術における抗血栓薬の出血制御に与える影響 A nationwide study in Japan based on the National Clinical DatabasePoster presentation
- JDDW2021(第29回日本消化器関連学会週間), Web開催/神戸, Domestic conference患者由来大腸癌オルガノイドを用いたバルプロ酸の新規治療薬としての有用性の検討Poster presentation
- JDDW2021(第29回日本消化器関連学会週間), Web開催/神戸, Domestic conferenceパネルディスカッション9 進行・再発消化器癌に対するconversion therapyの適応と限界Others
- 第22回腹腔鏡内視鏡合同研究会, Web開催膵臓側に位置する表在性非乳頭部十二指腸に対する腹腔鏡内視鏡合同手術の工夫Oral presentation
- 市民公開講座「大腸がん 知れば安心!知れば納得!~専門医による治療最前線~」, 中外製薬株式会社、神戸新聞社, Web開催大腸がんに対するゲノム医療Public discourse
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conference本邦における高齢者直腸癌患者に対する腹腔鏡手術の安全性の検討Invited oral presentation
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conferenceTaTMEを軸とした近未来の下部直腸癌手術Public symposium
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conferenceワークショップ17 切除不能消化器癌に対するconversion surgeryの適応とタイミングOthers
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conference臓器別シンポジウム6 局所進行食道がんに対する治療戦略Others
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conference学術セミナー11 食道がん治療の現状と展望~周術期治療と薬物療法~Others
- 第59回日本癌治療学会学術集会, Web開催/横浜, Domestic conferenceスポンサードシンポジウム2 大腸癌個別化治療の現状と今後の展望Others
- 日本外科代謝栄養学会第58回学術集会, Web開催/神戸, Domestic conference胃癌手術症例における欠損歯が予後に及ぼす影響についてOral presentation
- 日本外科代謝栄養学会第58回学術集会, Web開催/神戸, Domestic conference食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発Oral presentation
- 日本外科代謝栄養学会第58回学術集会, Web開催/神戸, Domestic conferenceワークショップ4 重症感染症に対する治療~その理論と実践~Others
- International Association of Surgeons, Gastroenterologists and Oncologists(IASGO-CME 2021), Web開催, International conferencePoster Discussion【B】 Esophagus/StomachOthers
- 第27回外科侵襲とサイトカイン研究会, Web開催/神戸, Domestic conference大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響Public symposium
- 神戸消化器癌フォーラム2021@Web, Web開催胃・大腸癌に対する最新集学的治療2021Public discourse
- 第80回日本癌学会学術総会, Web開催/横浜, Domestic conferenceオルガノイドの乳がん研究への展開Public symposium
- 第80回日本癌学会学術総会, Web開催/横浜, Domestic conference大腸癌臨床検体のマイクロ RNA 網羅的解析による新規大腸癌幹細胞制御機構の解明Invited oral presentation
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceProne Thoracoscopic Esophagectomy for Patients with Low Pulmonary Function
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceLaparoscopic creation of retrosternal route for gastric conduit reconstruction; safe and feasible procedureOral presentation
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceA case of G-CSF(granulocyte-colony stimulating factor) producing esophageal cancer with enteroblastic differentiationPoster presentation
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceThoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancerOral presentation
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceSurgical techniques and potential of mediastinal lymphadenectomy in robotic surgeryOral presentation
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), Web開催, International conferenceCurrent Status of Esophagectomy in Japanese National Clinical Database
- 第34回近畿内視鏡外科研究会, Web開催, Domestic conferenceロボット支援食道切除術の短期成績と learning curveOral presentation
- 第34回近畿内視鏡外科研究会, Web開催, Domestic conference腹臥位胸腔鏡下食道切除術における上縦隔郭清手技の工夫と定型化Oral presentation
- 第34回近畿内視鏡外科研究会, Web開催, Domestic conference当院における腹腔鏡下胃切除を安全に行うためのちょっとした工夫Public symposium
- 第34回近畿内視鏡外科研究会, Web開催, Domestic conference直腸癌手術における Robotic TaTME の可能性Nominated symposium
- 第34回近畿内視鏡外科研究会, Web開催, Domestic conference当科におけるロボット支援食道手術の課題と可能性Nominated symposium
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conference食道癌手術後の異時性胃癌(胃管癌)に対する全国実態調査Oral presentation
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conference術前HbA1c値と食道癌術後合併症の関連;NCD データ15801例の解析からPublic symposium
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conferenceLaparoscopic retrosternal route creation; short-term postoperative outcomesPoster presentation
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conferenceSafety and validity of thoracoscopic esophagectomy for elderly patientsPublic symposium
- 第75回日本食道学会学術集, Web開催/東京, Domestic conferenceEstablished upper mediastinum lymphadenectomy in prone MIE improves outcomesOral presentation
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conferenceValidity of lymphadenectomy for No.106recL estimated by Efficacy IndexPublic symposium
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conferenceワークショップ3 高齢者における食道癌手術の現状と課題Others
- 第75回日本食道学会学術集会, Web開催/東京, Domestic conference食道癌の集学的治療戦略2021Public discourse
- 第11回高知和漢医薬セミナー, Web開催がん診療におけるKAMPOPublic discourse
- 第30回消化器疾患病態治療研究会, Web開催, Domestic conference直腸癌術後縫合不全は長期予後を悪化させるのか?マウスモデルと臨床研究で得られた結果からの考察Oral presentation
- 第30回日本がん転移学会学術集会・総会, Web開催, Domestic conferenceFDG-PET検査によるリンパ節SUVmax値を用いた胃癌リンパ節転移診断の有用性の検討Poster presentation
- 第30回日本がん転移学会学術集会・総会, Web開催, Domestic conferenceStageIV切除不能胃癌に対する外科治療Public symposium
- 第30回日本がん転移学会学術集会・総会, Web開催, Domestic conference大腸癌腹膜播種モデルにおけるPMN-MDSCの役割Poster presentation
- 第30回日本がん転移学会学術集会・総会, Web開催, Domestic conferenceシンポジウム2 チームで取り組むがん転移Others
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceNCDデータを用いた食道切除後再建ルートの術後合併症への影響の解析Public symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceShort-Term Outcomes of Robot-Assisted Minimally invasive esophagectomyPublic symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference長期予後予測因子GPSと術後短期成績に関するNCD解析研究Public symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference飽和食塩溶液固定法を用いたCadaver Surgical Trainingの有用性Public symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference腹腔鏡による胸骨後経路作成の工夫と短期成績Oral presentation
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発と臨床的意義Oral presentation
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference至適術前治療選択のためのバイオマーカーの重要性Oral presentation
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference当院における胃・食道胃接合部癌に対する術前化学療法の治療成績の検討Oral presentation
- Web開催/京都, Domestic conferenceEstablished upper mediastinum lymphadenectomy in prone MIE improves outcomesPublic symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference直腸癌術後縫合不全は長期予後を悪化させるか?マウスモデルと臨床多施設共同研究で得られた結果からの考察Public symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceSimple and reliable transhiatal laparoscopic reconstruction for Siewert type II tumorPublic symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conference直腸癌術前化学放射線療法におけるCD8+T細胞の誘導とその予後Oral presentation
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferencetaTMEを安全に行うための工夫と手術成績,そして今後の展望Public symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferencePotential of robotic surgery surpassing conventional thoracoscopic esophagectomyPublic symposium
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceEducational Lecture 5 Surgery based on digital information: focusing on gastric cancer surgeryOthers
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceNCDデータを利活用した消化器外科領域臨床研究Public discourse
- 第76回日本消化器外科学会総会, Web開催/京都, Domestic conferenceランチョンセミナー8 がんゲノム医療時代における大腸癌薬物療法のトピックスOthers
- 第31回日本サイトメトリー学会学術集会, Web開催, Domestic conference放射線治療における腫瘍内CD8⁺T細胞の動態Oral presentation
- 第31回日本サイトメトリー学会学術集会, Web開催, Domestic conference大腸癌腹膜播腫モデルにおける骨髄由来免疫抑制細胞の機能Oral presentation
- 第31回日本サイトメトリー学会学術集会, Web開催, Domestic conference招聘シンポジウム 固形腫瘍の病態と最新の研究Others
- 第46回日本外科系連合学会学術集会, Web開催/東京, Domestic conferenceAbdominal robotic approach 併用によるHybrid taTMEの安全性Public symposium
- 第46回日本外科系連合学会学術集会, Web開催/東京当院におけるロボット支援下幽門側胃切除術の短期治療成績と定型化に向けた取り組みPublic symposium
- 第46回日本外科系連合学会学術集会, Web開催/東京, Domestic conference食道癌術後患者においてcomprehensive complication indexが予後に及ぼす影響Public symposium
- 第46回日本外科系連合学会学術集会, Web開催/東京, Domestic conferenceパネルディスカッション3 外科系各科におけるがん免疫療法Others
- 第64回関西胸部外科学会学術集会, Web開催, Domestic conference高齢食道癌患者に対する胸腔鏡下食道切除術の安全性と妥当性Oral presentation
- 第43回日本癌局所療法研究会, Web開催, Domestic conference右水腎症を伴う進行直腸癌に対し術前化学療法を施行し、病理学的完全奏功を得た1例Oral presentation
- 第43回日本癌局所療法研究会, Web開催, Domestic conference主題 4-1 高齢者 下部消化管、肝胆膵Others
- ベクティビックス全国Web講演会, Web開催大腸癌薬物療法 Right test, Right time, Right patientOthers
- 第75回手術手技研究会, Web開催/三島, Domestic conference食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチOral presentation
- 第75回手術手技研究会, Web開催/三島, Domestic conferencetaTMEの手術成績と手技の工夫Poster presentation
- 第75回手術手技研究会, Web開催/三島, Domestic conference十二指腸乳頭に近接する表在型腫瘍に対する乳頭損傷予防として膵管ステントを用いた腫瘍切除術式の検討Poster presentation
- AACR ANNUAL MEETING 2021, Web開催, International conferenceAntigen electroporated DC loaded with NKT-cell ligand induces the antigen specific antitumor immunityPoster presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conferenceNCDを用いた虫垂炎研究:虫垂炎手術における手術関連死ゼロを目指してOral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference急性汎発性腹膜炎手術における抗血栓薬の術中出血量・周術期出血/血栓合併症に対する影響~A nationwide study in Japan based on the National Clinical Database~Public symposium
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference食道神経内分泌細胞癌治療の現状と予後予測因子の検討Public symposium
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference膵管内乳頭粘液性癌に対する亜全胃温存膵頭十二指腸切除術後に細胆管癌を発症し、肝切除後胆汁瘻を合併した1例Poster presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference低肺機能食道癌患者に対する腹臥位胸腔鏡下食道切除術の安全性Oral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference高齢者の胃癌ESD後追加外科切除に関する検討Poster presentation
- Web開催当科におけるcStageIV胃癌に対するconversion surgeryの治療成績Poster presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conferenceFDG-PET検査によるリンパ節SUVmax値を用いた胃癌リンパ節転移診断の有用性の検討Public symposium
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference直腸癌NACRT症例におけるサルコペニアの影響Public symposium
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference食道癌におけるcomprehensive complication indexと長期予後の関係Oral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conferenceリンパ節転移比率はMinimally invasive esophagectomy(MIE)を施行した食道扁平上皮癌患者の独立予後因子であるOral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての好中球-リンパ球比の意義Poster presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference当科における胃腺癌・食道胃接合部腺癌に対する術前化学療法の治療成績Poster presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference最新内視鏡システムが腹腔鏡下胃癌手術にもたらすものPublic symposium
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference大腸癌腹膜播腫モデルにおける PD-L1 耐性とその克服Oral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference直腸癌におけるtransperineal minimally invasive APRの有用性:手術成績と定型化についてOral presentation
- 第121回日本外科学会定期学術集会, Web開催胃がん登録の現状とNCDへの実装Others
- 第121回日本外科学会定期学術集会, Web開催当科で行っている胸管温存,反回神経非遊離のen-bloc 縦隔郭清Oral presentation
- 第121回日本外科学会定期学術集会, Web開催, Domestic conference特別企画6 各疾患登録とNCDの課題と将来Others
- 第30回近畿GIST研究会, Japanese, 近畿GIST研究会、ファイザー株式会社, web開催, Japan, Domestic conferenceSession3 【パネルディスカッション】Others
- 第4回神戸消化器学術講演会, Japanese, ミヤリサン製薬株式会社, web開催, Japan, Domestic conference一般演題 食道癌に対するMIEの現状と教育Others
- 第4回神戸消化器学術講演会, Japanese, ミヤリサン製薬株式会社, web開催, Japan, Domestic conference開会のあいさつ[Invited]Others
- オプジーボ WEBライブセミナー, Japanese, 小野薬品工業株式会社、ブリストル・マイヤーズ・スクイブ株式会社, web開催, Japan, Domestic conference胃癌薬物療法のベストシークエンスとは~ニボルマブ~のベストポジションを考えるPublic discourse
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceComputer-based video analysis of device usage in laparoscopic gastrectomy.Public symposium
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceProne thoracoscopic esophagectomy for patients with low respiratory functionOral presentation
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceRobot-assisted gastrectomy: short-term outcomes and procedural standardization at a single hospitalOral presentation
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceHow much operative time does transanal approach reduce for male patients with rectal cancer?Public symposium
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceLaparoscopic vs. open right hemicolectomy: the Japanese National Clinical Database analysisPublic symposium
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceTransanal vs. laparoscopic TME for low rectal cancer: clinical outcomes and technical tipsPublic symposium
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceWhich surgical position is beneficial for thoracoscopic esophagectmoy?-Prone or lateral position-Poster presentation
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceNCDによるReal Worldデータが胃癌における手術手技を変える可能性Invited oral presentation
- 第33回日本内視鏡外科学会総会, Japanese, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, Japan, Domestic conferenceNational Clinical Databaseから見えてくる内視鏡外科手術の実像Invited oral presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference内科領域の現状と展望Oral presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference抗血栓療法中の患者に対する胃癌手術の安全性の検討Oral presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference当院におけるロボット支援下幽門側胃切除術の短期治療成績と定型化に向けた取り組みOral presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference高齢者に対する胃癌ESD後追加手術Public symposium
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference高齢進行胃・接合部癌患者に対する術前化学療法の安全性と有用性の検討Public symposium
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference術前化学療法を行いpCRを得られた6症例の検討Poster presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference高齢者の胃癌に対する胃切除範囲の予後に及ぼす影響Oral presentation
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conferenceパネルディスカッション2 胃癌周術期薬物治療の挑戦Others
- 第93回日本胃癌学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科, web開催, Japan, Domestic conferenceプレナリーセッション3 胃癌登録事業について[Invited]Public discourse
- 第27回日本がんチーム医療研究会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野、NPO法人堺臨床研究支援センター、日本がんチーム医療研究会, 大阪/web開催, Japan, Domestic conference当番世話人の挨拶 閉会Others
- 第27回日本がんチーム医療研究会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野、NPO法人堺臨床研究支援センター、日本がんチーム医療研究会, 大阪/web開催, Japan, Domestic conference特別シンポジウム『COVID-19 蔓延下のがん診療』Others
- 第27回日本がんチーム医療研究会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学分野、NPO法人堺臨床研究支援センター、日本がんチーム医療研究会, 大阪/web開催, Japan, Domestic conference当番世話人の挨拶 開会Others
- 第1回5四金会, Japanese, 5四金会、科研製薬株式会社, 神戸/web開催, Japan, Domestic conference5G世代の胃癌手術Invited oral presentation
- 第8回日本神経内分泌腫瘍研究会学術集会, Japanese, 横浜市立大学大学院医学研究科 がん総合医科学, web開催, Japan, Domestic conference胃原発混合神経内分泌非神経内分泌腫瘍(MiNEN)の全エクソームシークエンスによる解析Oral presentation
- 兵庫県消化器外科研究会, Japanese, 兵庫県消化器外科研究会・小野薬品工業株式会社, web開催, Japan, Domestic conference基調講演「当科における大腸外科医育成」[Invited]Oral presentation
- Gastrointestinal Cancers Symposium(ASCO GI 2021), English, ASCO, web開催, International conferenceConfirmed three-year RFS and OS of the randomized trial of adjuvant S-1 versus S-1 plus docetaxel after curative resection of pStage III gastric cancer (JACCRO GC-07).Oral presentation
- 第51回日本膵臓学会大会, Japanese, 近畿大学医学部外科学教室 肝胆膵部門, 神戸/web開催, Japan, Domestic conferenceNational clinical databaseによる膵全摘術の術後重症合併症リスクモデルInvited oral presentation
- 第45回日本外科系連合学会学術集会, Japanese, 久留米大学病院 腫瘍センター, web開催, Japan, Domestic conference女性外科医のキャリア・アップを目指した一歩踏み込んだサポート体制Public symposium
- 第45回日本外科系連合学会学術集会, Japanese, 久留米大学病院 腫瘍センター, web開催, Japan, Domestic conferenceシンポジウム6 分子標的剤で変ったがん集学的治療Others
- 第108回日本泌尿器科学会総会, Japanese, 神戸大学大学院医学研究科 腎泌尿器科学分野, 神戸/Web開催, Japan, Domestic conference消化器外科領域でのNCDへの取り組みについてPublic discourse
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceStandardization of upper mediastinal lymphadenectomy in prone thoracoscopic esophagectomy(腹臥位胸腔鏡下食道切除術における上縦隔郭清の定型化)Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceSurgical outcomes and technical tips of transanal total mesorectal excision for low rectal cancer (下部直腸癌に対するtaTMEの手術成績(vs. lap TME)と安全に行うための工夫)Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceFeasibility of thoracic duct preservation in esophageal SCC: a propensity score matchied-cohort study(食道扁平上皮癌に対する食道切除における胸管温存の妥当性~傾向スコアを用いた後ろ向きコホート研究~)Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceStandardization of the robotic esophagectomy based on standardized minimally invasive esophagectomy(胸腔鏡手術との互換性から考えるロボット支援下食道切除術への移行と定型化)Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceWorkshop14 Future perspectives of cancer genomic medicine in gastroenterological surgeryOthers
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference腹腔鏡手術の安全性に注目した、本邦での高齢者に対する大腸手術成績の検討~NCDデータを用いて~Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference腹腔鏡下胃切除術動画における手術器具自動認識システムの開発と臨床研究への応用Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference高齢食道癌患者に対する胸腔鏡下手術の有用性Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference腹腔鏡による安全な胸骨後経路作成の工夫Oral presentation
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference当院におけるロボット支援下胃切除術の短期治療成績と定型化に向けた取り組みOral presentation
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference臨床的側方リンパ節転移陽性直腸癌に対する術前化学放射線療法に伴う直腸癌手術後の再発リスクの検討Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference胃癌ESD後の追加外科切除に関する検討Oral presentation
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference局所進行胃癌に対する術前化学療法著効症例において術後補助化学療法は省略可能かOral presentation
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference腹膜播種における骨髄由来免疫抑制性細胞の働きとその治療応用Oral presentation
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conference高度進行胃癌に対するConversion surgeryの検討Public symposium
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceランチョンセミナー4[Invited]Public discourse
- 第75回日本消化器外科学会総会, Japanese, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, Japan, Domestic conferenceComparison of 3D and 4K for laparoscopic gastrectomy for gastric cancer(腹腔鏡下胃癌手術の手術成績に関する内視鏡画像システム(3Dvs4K)のランダム化比較試験)Public symposium
- 第74回日本食道学会学術集会, Japanese, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, Japan, Domestic conference食道裂孔ヘルニア・胃食道逆流症の外科治療の全国実態調査Public symposium
- 第74回日本食道学会学術集会, Japanese, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, Japan, Domestic conferenceEstablished upper mediastinum lymphadenectomy in prone MIE improves outcomesPublic symposium
- 第74回日本食道学会学術集会, Japanese, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, Japan, Domestic conferenceFeasibility of lymphadenectomy with thoracic duct preservation in esophageal SCCPublic symposium
- 第74回日本食道学会学術集会, Japanese, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, Japan, Domestic conference表在型食道癌(pMM/SM1)に対する胸腔鏡下食道切除術の治療成績Public symposium
- Japanese, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, Japan, Domestic conferenceワークショップ3 初回治療後の病期診断の現況とブレークスルー(領域横断的セッション)Others
- 第24回バイオ治療法研究会学術集会, Japanese, 福岡大学医学部産科婦人科学講座、福岡がん総合クリニック, web開催, Japan, Domestic conference食道癌術前化学療法の効果予測因子における癌幹細胞マーカーの有用性に関する検討Oral presentation
- 第24回バイオ治療法研究会学術集会, Japanese, 福岡大学医学部産科婦人科学講座、福岡がん総合クリニック, web開催, Japan, Domestic conference腹膜播種における腹腔内MDSCの役割Oral presentation
- 第21回神戸外科WEBフォ-ラム, Japanese, 大鵬薬品工業株式会社, web開催, Japan, Domestic conference特別講演「ロボット胃がん手術:安全に行うためのコツと今後の可能性」Others
- ESOPHAGEAL CANCER EXPERT FORUM, Japanese, 小野薬品工業株式会社、Bristol Myers Squibb, web開催, Japan, Domestic conferenceSESSION2 Clinical Question の治療戦略を考えるOthers
- 第33回日本外科感染症学会総会学術集会, Japanese, 防衛医科大学校 外科学講座, web開催, Japan, Domestic conferenceNACRT 施行後腹会陰式直腸切断術における大網充填術の有用性Poster presentation
- 第33回日本外科感染症学会総会学術集会, Japanese, 防衛医科大学校 外科学講座, web開催, Japan, Domestic conference高齢者胃癌切除後の肺炎併発による長期予後への影響の検討Public symposium
- 第33回日本外科感染症学会総会学術集会, Japanese, 防衛医科大学校 外科学講座, web開催, Japan, Domestic conference直腸癌術後縫合不全は長期予後を悪化させるのか?Poster presentation
- 第33回日本外科感染症学会総会学術集会, Japanese, 防衛医科大学校 外科学講座, web開催, Japan, Domestic conferenceNCD データから見る、高齢者に対する腹腔鏡下直腸手術と SSI 発生の関連についてPublic symposium
- 第188回 兵庫県外科医会学術集会, Japanese, 兵庫県外科医会、コヴィディエンジャパン株式会社, 姫路/Web開催, Japan, Domestic conference挨拶[Invited]Others
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference直腸癌に対するTa-TME併用直腸切除術の手術手技と手術成績Public symposium
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference鼠経リンパ節転移陽性直腸癌に対する治療戦略Oral presentation
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, Japan, Domestic conference大腸癌腹膜播種の病勢に骨髄由来免疫抑制細胞が及ぼす影響とその治療応用Public symposium
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院医学研究科 消化器外科, web開催, Japan, Domestic conference放射線治療は、腫瘍内CD8+T細胞の増加とサイトカイン産生を増強し、抗腫瘍効果に寄与するPublic symposium
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院医学研究科 消化器外科, web開催, Japan, Domestic conference腫瘍関連マクロファージ由来のCCL1はCCR8を介して食道扁平上皮癌の運動能・浸潤能を亢進させるOral presentation
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院医学研究科 消化器外科, web開催, Japan, Domestic conference癌関連線維芽細胞はPAI-1の分泌を介して食道扁平上皮癌の進展に寄与するOral presentation
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院医学研究科 消化器外科, web開催, Japan, Domestic conference当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討Public symposium
- 第31回日本消化器癌発生学会総会, Japanese, 大阪市立大学大学院医学研究科 消化器外科, web開催, Japan, Domestic conference共催セミナー4 消化器癌におけるオキサリプラチンの臨床的意義[Invited]Public discourse
- 神戸消化器癌フォーラム2020@web, Japanese, 日本化薬株式会社, web開催, Japan, Domestic conference胃癌に対する最新集学的治療[Invited]Invited oral presentation
- 第50回胃外科・術後障害研究会, Japanese, 帝京大学医学部外科学講座, web開催, Japan, Domestic conference当科における胃癌および食道胃接合部癌に対する術前化学療法の治療成績Public symposium
- 第50回胃外科・術後障害研究会, Japanese, 帝京大学医学部外科学講座, web開催, Japan, Domestic conference胃癌治療の目指すものPublic discourse
- 第50回胃外科・術後障害研究会, Japanese, 帝京大学医学部外科学講座, web開催, Japan, Domestic conference主題1-2 「化学療法後の胃癌手術」Others
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan完全腹腔鏡下幽門側胃切除における点墨による胃切離線決定法の有用性Poster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conferenceNACRT施行後腹会陰式直腸切断術における大網充填術の有用性Poster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conference低肺機能に対する腹臥位胸腔鏡下食道切除術Poster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conference食道胃接合部癌Siewert2型におけるリンパ節転移の予後への影響Poster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conferenceStageⅣ胃癌に対するconversion surgeryPoster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conference十二指腸乳頭に近接する表在型腫瘍に対する乳頭損傷予防として膵管ステントを用いた腫瘍切除術式の検討Poster presentation
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conference高齢者の胃癌手術における腎機能障害度の合併症発生に及ぼす影響Public symposium
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conferenceランチョンセミナー63 ニボルマブが変える食道癌薬物治療戦略[Invited]Public discourse
- JDDW2020(第28回日本消化器関連学会週間), Japanese, 一般社団法人日本消化器関連学会機構, 神戸/web開催, Japan, Domestic conferenceワークショップ13 消化器悪性疾患に対するconversion surgeryOthers
- 第73回日本胸部外科学会定期学術集会, Japanese, 名古屋大学大学院医学系研究科 心臓外科学, web開催, Japan, Domestic conference飽和食塩溶液固定法を用いた腹臥位胸腔鏡下食道切除術のCadaver Surgical TrainingInvited oral presentation
- 第73回日本胸部外科学会定期学術集会, Japanese, 名古屋大学大学院医学系研究科 心臓外科学, web開催, Japan, Domestic conference大動脈食道瘻の治療戦略-消化器外科の観点から-Public symposium
- 第82回日本臨床外科学会総会, Japanese, 大阪医科大学 外科学講座 一般・消化器外科, web開催, Japan, Domestic conference総会特別企画09 5G時代の遠隔医療-システム構築と外科治療-Others
- 第58回日本癌治療学会学術集会, Japanese, 日本医科大学大学院医学研究科 呼吸器内科学分野, 京都/web開催, Japan, Domestic conference胃がんにおける抗HER2抗体による術前治療および免疫チェックポイント阻害薬の展望Public symposium
- 第58回日本癌治療学会学術集会, Japanese, 日本医科大学大学院医学研究科 呼吸器内科学分野、MSD株式会社, 京都/Web開催, Japan, Domestic conference学術セミナー42 消化器癌免疫療法におけるバイオマーカーと治療戦略Public discourse
- 第11回神戸栄養研究会, Japanese, 神戸大学医学部附属病院 栄養輸液サポートチーム(NEST)、アボットジャパン合同会社, web開催, Japan特別講演「癌治療と栄養学を考える」Others
- Leader's Meeting in Kansai & Tokyo, Japanese, メルクバイオファーマ株式会社, 大阪, JapanSpecial Lecture『ゲノム診療の時代に改めて抗EGFR抗体薬治療を考える』Others
- 第74回手術手技研究会, Japanese, 大阪大学大学院 消化器外科学, 松江, Japan, Domestic conferenceサージカルフォーラム 胃1Others
- 第33回兵庫大腸癌治療研究会, Japanese, 兵庫大腸癌治療研究会、兵庫県がん診療連携協議会、大鵬薬品工業株式会社、ミヤリサン製薬株式会社, web開催, Japan特別講演『大腸ステントの現状と将来展望』Others
- 第79回日本癌学会学術総会, Japanese, 広島大学大学院医系化学研究科 分子病理学, 広島, Japan, Domestic conference潜在転移ヒト乳がん幹細胞のマイクロRNAプロファイルInvited oral presentation
- 第79回日本癌学会学術総会, Japanese, 広島大学大学院医系化学研究科 分子病理学, 広島, Japan, Domestic conference放射線治療は新たに浸潤するCD8+T細胞を増強し、腫瘍内CD8+T細胞の増加と抗腫瘍効果に寄与する。Poster presentation
- 第203回近畿外科学会, Japanese, 大阪市立大学大学院医学研究科 消化器外科、乳腺・内分泌外科学, webおよび誌上開催, Japan, Domestic conferenceKillian-Jamieson 憩室内に発生した食道癌の一例Oral presentation
- 第203回近畿外科学会, Japanese, 大阪市立大学大学院医学研究科 消化器外科、乳腺・内分泌外科学, webおよび誌上開催, Japan, Domestic conferenceTa-TME併用による腹会陰式直腸切断術の手術手技と手術成績Oral presentation
- 第33回近畿内視鏡外科研究会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学 乳腺・内分泌外科学, web開催, Japan, Domestic conference当科における下部直腸癌に対するtaTMEの手術手技と手術成績Public symposium
- 第33回近畿内視鏡外科研究会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学 乳腺・内分泌外科学, web開催, Japan, Domestic conference低肺機能食道患者に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第33回近畿内視鏡外科研究会, Japanese, 大阪市立大学大学院 医学研究科 消化器外科学 乳腺・内分泌外科学, web開催, Japan, Domestic conference腹臥位胸腔鏡下食道切除における上縦隔郭清の工夫Public symposium
- 食道癌免疫療法セミナー, Japanese, 小野薬品工業株式会社、ブリストル・マイヤーズスクイブ株式会社, web開催, JapanプロローグOthers
- Gastric Cancer Cross-Clinical Seminar In KOBE, Japanese, 大鵬薬品工業株式会社、7大学連携個別化がん医療, web開催, JapanSession2 【手術】胃癌に対するロボット手術Others
- 大腸がんWEBセミナー =Kobe Program=, Japanese, 武田薬品工業株式会社, web開催, Japan大腸がんの治療戦略 リキッドバイオプシーをどう生かすかOthers
- 第7回平成大腸癌カンファレンス, Japanese, 中外製薬株式会社, web開催, JapanSession2 大腸がん化学療法について伝えたい3つの事柄Others
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conferenceACS-NSQIPに学ぶ, 外科医療成績向上に向けた取り組みInvited oral presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道癌手術における術前の歯牙欠損と術後の予後との関係Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference胸部食道癌術後にsevereな体重減少を認める症例は予後不良であり、周術期に短期的な経腸栄養を行っても改善しないPoster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference間葉系幹細胞由来のCXCL16は胃癌細胞においてSTAT3経路を介してRor1の発現を誘導し増殖と遊走を促進するPoster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道亜全摘術の再建経路選択におけるICG蛍光観察法の有用性Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conferenceオープンソースの物体検出アルゴリズムを用いた腹腔鏡下胃癌手術ビデオにおける手術器具自動認識システムの開発と利用Invited oral presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道癌手術における術後合併症予測因子及び長期予後予測因子としてのSurgical Apgar Scoreの有用性Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道胃接合部癌 Siewert2 型におけるリンパ節転移の予後への影響Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference直腸癌術後縫合不全は長期予後を悪化させるのか?Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference当院における腹腔鏡下胃全摘術の安全性と有用性Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術~腫瘍局在に応じた外科手技の工夫と治療成績~Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference術後腹膜炎が転移を促進させる-マウス腹膜炎モデルにおける肺転移への影響Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference「外側先行剥離」による新しいTaTME手技Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conferenceロボット支援手術における上縦隔郭清手技とその可能性Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道癌に対する胸腔鏡下手術の治療成績Public symposium
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conference食道胃接合部腺癌に対する術前補助化学療法の検討Poster presentation
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室、バイエル薬品株式会社, web開催, Japan, Domestic conferenceイブニングセミナー(8) 「大腸癌化学療法~Late Lineの治療戦略~」Public discourse
- 第120回日本外科学会定期学術集会, Japanese, 慶応義塾大学医学部外科学教室, web開催, Japan, Domestic conferenceワークショップ(19)「上部消化管機能温存術式のエビデンス」Public symposium
- 第92回日本胃癌学会総会, Japanese, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferencePostoperative Adjuvant Chemotherapy in Patients with Stage III Gastric Cancer:JACCRO GC-07Public symposium
- 第92回日本胃癌学会総会, Japanese, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceTreatment choices after recurrence in patients with stage III gastric cancer in JACCRO GC-07 studyOral presentation
- 第92回日本胃癌学会総会, Japanese, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceFeasibility of laparoscopic gastrectomy for patients with poor physical status: a NCD-based studyOral presentation
- 第92回日本胃癌学会総会, Japanese, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceNCDデータを用いた胃全摘術後合併症に対するHospital Volumeの影響Oral presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Domestic conferencePreoperative endoscopic tattooing using India ink for totally laparoscopic distal gastrectomyOral presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceConversion surgery following chemotherapy for Stage Ⅳ gastric cancer
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferencePerspective of newer treatments of Schirrus-Type gastric cancer or peritoneal disseminationPublic symposium
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceリンパ節転移を伴う早期胃癌の予後に関する検討Oral presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conference抗血栓療法中患者に対する胃切除術における周術期抗血栓療法の検討Poster presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conference高齢者局所進行胃癌に対する術前化学療法の有効性と安全性Oral presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conferenceSiewert Ⅱ型食道胃接合部癌に対する偽His角・fornix形成食道胃管再建Poster presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conference食道胃接合部腺癌に対する術前補助化学療法の有用性Oral presentation
- 第92回日本胃癌学会総会, English, 国立がん研究センター 先端医療開発センター, web開催, Japan, Domestic conference口演25 合併症/術後障害3Oral presentation
- 第41回癌免疫外科研究会, Japanese, 大阪大学大学院医学系研究科 臨床腫瘍免疫学, 大阪, Japan, Domestic conference腹膜播種の病勢に腹腔内骨髄由来抑制細胞が及ぼす影響と、治療標的としての可能性Oral presentation
- 第41回癌免疫外科研究会, Japanese, 大阪大学大学院医学系研究科 臨床腫瘍免疫学, 大阪, Japan, Domestic conferenceNKT細胞ワクチンベクターの抗原特異的T細胞の活性化Oral presentation
- 第41回癌免疫外科研究会, Japanese, 大阪大学大学院医学系研究科 臨床腫瘍免疫学, 大阪, Japan, Domestic conference一般口演1 局所微小環境1Oral presentation
- AACR Annual Meeting 2020, English, web開催, International conferenceAntigen specific antitumor effect induced by antigen-electroporated, natural killer T cell ligand-loaded dendritic cellsPoster presentation
- AACR Annual Meeting 2020, English, web開催, International conferenceRadiationtherapy for tumors enhances newly-infiltrating CD8⁺T cells and contributes to the increase of intratumor CD8⁺T cells and anti-tumor effects.Poster presentation
- オプジーボWEBライブセミナー, Japanese, ブリストル・マイヤーズ スクイブ株式会社、小野薬品工業株式会社, web開催, Japan食道癌治療の新時代~ニボルマブをどう使いこなすか?~Public discourse
- Next TV Symposium -胃がんのトータルマネジメント-, Japanese, 第一三共株式会社・アストラゼネカ株式会社, Japan, Domestic conference胃がんの最新治療Public discourse
- Next TV Symposium -胃がんのトータルマネジメント-, Japanese, 第一三共株式会社・アストラゼネカ株式会社, Japan, Domestic conference対策型胃内視鏡検診の導入と課題 -AIによる診断支援の可能性ーPublic discourse
- 日本消化器病学会近畿支部第112回例会, Japanese, 京都府立医科大学大学院医学研究科消化器内科学, 誌上開催, Japan, Domestic conference高齢食道癌患者に対する胸腔鏡下手術の意義と適応Public symposium
- 日本消化器病学会近畿支部第112回例会, Japanese, 京都府立医科大学大学院医学研究科消化器内科学, 誌上開催, Japan, Domestic conference当科における鼠径リンパ節転移陽性直腸癌に治療成績Oral presentation
- 第53回制癌剤適応研究会, 京都府立医科大学大学院医学研究科 消化器外科学, 滋賀, Japan, Domestic conference当科における鼠径リンパ節転移陽性直腸癌の治療戦略Poster presentation
- 第53回制癌剤適応研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 滋賀, Japan, Domestic conference局所進行直腸癌に対する術前化学放射線療法における治療成績の比較検討Poster presentation
- 第53回制癌剤適応研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 滋賀, Japan, Domestic conference当院における高頻度マイクロサテライト不安定性大腸癌のスクリーニング方法の検討Public symposium
- 第53回制癌剤適応研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 滋賀, Japan, Domestic conference食道扁平上皮癌術前化学療法によるPD-L1発現とCD8陽性腫瘍浸潤リンパ球の誘導Public symposium
- 第53回制癌剤適応研究会, Japanese, 京都府立医科大学大学院医学研究科 消化器外科学, 滋賀, Japan, Domestic conferenceランチョンセミナーPublic discourse
- 岐阜外科漢方フォーラム, Japanese, 株式会社ツムラ, 岐阜, Japan, Domestic conference漢方を使う消化管集学的治療Public discourse
- Japanese, 名古屋市立大学大学院 医学研究科 次世代医療開発学, 姫路, Japan, Domestic conferenceG-CSF(granulicyte-colony stimulating factor)産生胎児消化管上皮類似食道癌の1例Oral presentation
- 第16回日本消化管学会総会学術集会, Japanese, 名古屋市立大学大学院 医学研究科 次世代医療開発学, 姫路, Japan, Domestic conference輸血依存の重症再生不良性貧血経過中に大腸癌術後の穿通性吻合部潰瘍を発症し周術期管理が奏効した1例Oral presentation
- 15th ANNUAL ACADEMIC SURGICAL CONGRESS, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Florida, United States, International conferenceContribution of 3-dimensional system in advance of Minimally Invasive Esophagectomy.Oral presentation
- 15th ANNUAL ACADEMIC SURGICAL CONGRESS, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Florida, United States, International conferenceInfluence of Lymphatic Metastasis on the Recurrence of Adenocarcinoma of the Esophagogastric JunctionOral presentation
- 第1回おかやま地域医療連携講演会, Japanese, 株式会社ツムラ, 岡山, Japan, Domestic conferenceがん診療におけるKAMPO[Invited]Invited oral presentation
- おかやま地域医療連携講演会, Japanese, 株式会社ツムラ, 岡山, Japan, Domestic conferenceがん治療におけるKAMPOPublic discourse
- 神戸消化器外科Seminar, Japanese, テルモ株式会社, 神戸, Japan, Domestic conference特別講演Invited oral presentation
- 第96回大腸癌研究会, Japanese, 広島大学大学院医系科学研究科 内視鏡医学, 広島, Japan, Domestic conferenceStageⅢ大腸癌術後補助化学療法の検討Oral presentation
- ASCB EMBO 2019 meeting, English, Stanford University,Harvard Medical School and Dana Farber Cancer Institute, Washington, United States, International conferenceMesenchymal Stromal Cell-derived CXCL16 Promotes Proliferation and Migration of Gastric Cancer Cells by Inducing STAT3-mediated Expression of Ror1Oral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conferenceミラーイメージの克服についての工夫と検討、左右差についてOral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference完全腹腔鏡下幽門側胃切除術における点墨による病変マーキングの有用性Oral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conferenceASA class 3,4 のhigh risk 大腸癌患者における腹腔鏡手術の有用性Oral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference低肺機能に対する腹臥位胸腔鏡下食道切除術Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference腹腔鏡下噴門側胃切除後の食道胃管再建に関する検討Oral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference評価型外科縫合シミュレーターを活用した研修医・専攻医に対する腹腔鏡縫合結紮トレーニングOral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference吻合を用いた腹腔鏡下胃全摘の検討Oral presentation
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conferenceロボット支援Minimally invasive esophagectomy の可能性Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference腹腔鏡下結腸右半切除D3 郭清における頭側アプローチの有用性Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference外側先行剥離によるTa-TME の標準化Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conference施設内定型化郭清手技による反回神経麻痺の低減Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conferenceEducational Lecture 20Public symposium
- 第32回日本内視鏡外科学会総会, Japanese, 東海大学医学部消化器外科, 横浜, Japan, Domestic conferenceSurgical Forum76Public symposium
- 第23回バイオ治療法研究会学術集会, Japanese, 新潟薬科大学 健康・自立総合研究機構, 新潟, Japan, Domestic conferenceα-ガラクトシルセラミドを付加し、腫瘍抗原を導入した樹状細胞ワクチンベクターの抗腫瘍効果Oral presentation
- 7th FACO Academic Conference, English, Chinese Society of Clinical Oncology, Shanghai, China, International conferenceWhen should esophagectomy be performed to non-curative superficial esophageal cancer after endoscopic resection?Poster presentation
- 7th FACO Academic Conference, English, Chinese Society of Clinical Oncology, Shanghai, China, International conferenceTreatment Strategy for Rectal Cancer Patients With Inguinal Lymph Node MetastasisPoster presentation
- 7th FACO Academic Conference, English, Chinese Society of Clinical Oncology, Shanghai, China, International conferenceSafety of preoperative chemotherapy for elderly gastric cancer patientsPoster presentation
- 第3回神戸消化器学術講演会, Japanese, ミヤリサン製薬株式会社, 神戸, Japan, Domestic conference一般演題Oral presentation
- 第28回日本コンピューター外科学会大会, Japanese, 東京大学医学部附属病院 心臓外科, 東京, Japan, Domestic conference物体検出アルゴリズムを用いた鉗子軌道解析法の開発Oral presentation
- JDDW2019, Japanese, 兵庫医科大学 内科学消化管科, 神戸, Japan, Domestic conference消化器がん患者におけるサルコペニア対策についてPublic symposium
- 第3回日本先制臨床医学会学術大会, Japanese, 一般社団法人日本先制臨床学会, 神戸, Japan, Domestic conference消化器癌集学的治療と漢方Invited oral presentation
- 第81回日本臨床外科学会総会, Japanese, 高知大学外科学講座外科1, 高知, Japan, Domestic conference第23回 臨床研究セミナー 第1部 臨床研究の基礎講座Public discourse
- 第81回日本臨床外科学会総会, Japanese, 高知大学外科学講座外科1, 高知, Japan, Domestic conferenceシンポジウム02 消化管外科手術における縫合不全対策について考える1Public symposium
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conferenceα-ガラクトシルセラミドを付加し、 腫瘍抗原を導入した樹状細胞ワクチンベクターの抗腫瘍効果Public symposium
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference当院における高頻度マイクロサテライト不安定性大腸癌のスクリーニング方法の検討Public symposium
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference当科における鼠径リンパ節転移陽性直腸癌の治療戦略と成績Poster presentation
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference食道扁平上皮癌術前化学療法によるPD-L1発現とCD8陽性腫瘍浸潤リンパ球の誘導Public symposium
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference腹膜播種における腹腔内腫瘍免疫微小環境の解析Public symposium
- 第30回日本消化器癌発生学会総会, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は省略可能かPublic symposium
- 第30回日本消化器癌発生学会総会, Japanese, 一般社団法人 日本消化器癌発生学会, 横浜, Japan, Domestic conference理事長講演 日本消化器癌発生学会の「創始と継志」–次の10年Keynote oral presentation
- 第18回兵庫胃がん治療研究会, Japanese, 兵庫胃がん治療研究会、兵庫県がん診療連携協議会、大鵬薬品工業㈱, 神戸, Japan, Domestic conferenceセッションⅠ内視鏡Oral presentation
- Millennial Seminar of GI Cancer, Japanese, 中外製薬株式会社, 神戸, Japan, International conferenceClosing RemarksOthers
- Millennial Seminar of GI Cancer, Japanese, 中外製薬株式会社, 神戸, Japan, Domestic conference特別講演2Invited oral presentation
- 第49回胃外科・術後障害研究会, Japanese, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, Japan, Domestic conference高齢者の胃癌切除後における炎症に基づく予後予測スコアの有用性Public symposium
- 第49回胃外科・術後障害研究会, Japanese, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, Japan, Domestic conference完全腹腔鏡下幽門側胃切除術における点墨による病変マーキングの有用性Poster presentation
- 第49回胃外科・術後障害研究会, Japanese, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, Japan, Domestic conference早期胃癌に対するESD後追加外科切除例の検討Public symposium
- 第49回胃外科・術後障害研究会, Japanese, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, Japan, Domestic conference食道胃接合部に近接するGISTに対する噴門機能を温存した腹腔鏡下局所切除の安全性に関する検討Public symposium
- 第49回胃外科・術後障害研究会, Japanese, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, Japan, Domestic conferenceシンポジウム4-2 [切られる胃1-2]Others
- 第17回神戸消化器外科懇話会, Japanese, 神戸消化器外科懇話会、株式会社大塚製薬工業、イーエヌ大塚製薬株式会社, 神戸, Japan, Domestic conference特別講演ⅠOral presentation
- 第20回神戸外科フォーラム, Japanese, 大鵬薬品工業株式会社, 神戸, Japan, Domestic conference特別講演Ⅰ[Invited]Others
- 第20回神戸外科フォーラム, Japanese, 大鵬薬品工業株式会社, 神戸, Japan, Domestic conference開会の挨拶Others
- 第12回大分消化器癌治療研究会, Japanese, 大鵬薬品工業株式会社, 大分, Japan, Domestic conference令和の胃癌集学的治療戦略Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference5-ALAを用いた胃癌審査腹腔鏡検査の光線力学診断を検討する医師主導検証治験Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference歯牙欠損は食道癌術後の予後を悪化させるOral presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference食道扁平上皮癌術前化学療法によるPD-L1発現とCD8陽性腫瘍浸潤リンパ球の誘導Oral presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference局所進行胃癌に対するneoadjuvant cheterapyとしてのSOX療法の安全性Poster presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference抗血栓薬内服患者に対する胃切除術における周術期抗血栓療法の検討Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference食道癌手術治療に対するエノキサパリンによる静脈血栓塞栓症予防Poster presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference鼠径リンパ節転移を伴う直腸癌に対する術前化学放射線療法Oral presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conferenceStageⅣ胃癌に対するconversion surgeryの検討Oral presentation
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference内視鏡治療後非治癒切除症例に対する食道切除術の意義と適応Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conferenceNCDを活用した消化器外科診療Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference胃がんの最新治療Public symposium
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conferenceワークショップ13 ビッグデータを生かしたがんの診療と研究Others
- 第57回日本癌治療学会学術集会, Japanese, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, Japan, Domestic conference大腸がん個別化治療を上手に使いこなす〜プレシジョンメディシンの実践〜Public discourse
- 第57回癌治療に関する医療統計勉強会, Japanese, 癌治療に関する医療統計勉強会、中外製薬株式会社, 大阪, Japan, Domestic conferenceNational Clinical Database(NCD)の現状と展望についてOthers
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference腹腔鏡下に切除し得た副腎腫瘤を合併した家族性大腸ポリポーシスの1例Oral presentation
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference胸腔鏡下核出術を施行した食道神経鞘腫の一例Oral presentation
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference術前化学療法中にG-CSF(granulocyte-colony stimulating factor)産生腫瘍の診断を得た進行食道腺癌Oral presentation
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference早期胃癌に対するESD後の追加外科切除奨励の検討Public symposium
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference十二指腸病変に対する腹腔鏡内視鏡合同手術の検討Public symposium
- 日本消化器病学会近畿支部第111回例会, Japanese, 神戸大学大学院医学研究科 外科学講座 食道胃腸外科学, 大阪, Japan, Domestic conference外側先行剥離による安全なTa-TME手技の確立Public symposium
- 第78回日本癌学会学術総会, Japanese, 京都大学大学院 生命科学研究科, 京都, Japan, Domestic conferenceヒト乳がん異種移植モデルの微小転移がん幹細胞で発現低下しているマイクロRNA-93の解析Poster presentation
- 第78回日本癌学会学術総会, Japanese, 京都大学大学院 生命科学研究科, 京都, Japan, Domestic conference間葉系間質細胞由来のCXCL16は胃癌細胞においてRor1の発現を誘導し増殖と遊走を促進するPoster presentation
- 第78回日本癌学会学術総会, Japanese, 京都大学大学院 生命科学研究科, 京都, Japan, Domestic conference食道がん:病態・治療戦略Others
- 第202回近畿外科学会, Japanese, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, Japan, Domestic conference完全内臓逆位を伴うS状結腸癌に対して腹腔鏡下S状結腸切除を施行した一例Oral presentation
- 第202回近畿外科学会, Japanese, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, Japan, Domestic conference炎症による反復性幽門狭窄をきたした胃異所性膵に対して腹腔鏡下幽門側胃切除術を行った1例Oral presentation
- 第202回近畿外科学会, Japanese, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, Japan, Domestic conference後縦隔経路再建胃管癌に対する腹臥位胸腔鏡下胃管全摘術の2例Oral presentation
- 第202回近畿外科学会, Japanese, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, Japan, Domestic conference鼠径リンパ節転移陽性直腸癌に対する治療戦略Oral presentation
- 第202回近畿外科学会, Japanese, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, Japan, Domestic conference大動脈十二指腸瘻の治療経験Oral presentation
- 第32回近畿内視鏡外科研究会, Japanese, 大阪大学大学院医学系研究科 産科学婦人科学教室, 大阪, Japan, Domestic conference頭側アプローチによる腹腔鏡下右半結腸切除Public symposium
- 第32回近畿内視鏡外科研究会, Japanese, 大阪大学大学院医学系研究科 産科学婦人科学教室, 大阪, Japan, Domestic conference腹臥位胸腔鏡下食道切除における上縦隔郭清の定形化Public symposium
- 第32回近畿内視鏡外科研究会, Japanese, 大阪大学大学院医学系研究科 産科学婦人科学教室, 大阪, Japan, Domestic conferenceワークショップ5 手術教育 教える側の努力、工夫Public symposium
- 第1回神戸消化器癌フォーラム, Japanese, 日本化薬株式会社, 神戸, Japan, Domestic conference大腸癌に対する最新集学的治療[Invited]Invited oral presentation
- 第25回関西がんチーム医療研究会, Japanese, 田附興風会医学研究所 北野病院、関西がんチーム医療研究所, 大阪, Japan, Domestic conference消化管集学的治療における漢方薬の役割Nominated symposium
- 兵庫DKTフォーラム, Japanese, 株式会社ツムラ 神戸支店, 神戸, Japan, Domestic conferenceオープニングリマークスOthers
- 第28回消化器疾患病態治療研究会, Japanese, 愛知医科大学 消化管内科, 名古屋, Japan, Domestic conference胃管癌に対する低侵襲治療Oral presentation
- 第28回消化器疾患病態治療研究会, Japanese, 愛知医科大学 消化管内科, 名古屋, Japan, Domestic conference当院における胃SMT に対する腹腔鏡手術に関する検討Oral presentation
- 日本・モンゴル国際消化器がんシンポジウム, Japanese, Ulaanbaatar, Mongolia, International conferenceSafety and effectiveness of laparoscopic colorectomy for elderly patients: A propensity-score matching analysisOral presentation
- 日本・モンゴル国際消化器がんシンポジウム, English, Ulaanbaatar, Mongolia, International conferenceTransanal total mesorectal excision for rectal cancer by two-surgeon teamOral presentation
- 日本・モンゴル国際消化器がんシンポジウム, Japanese, Ulaanbaatar, Mongolia, International conferenceLaparoscopic surgery for gastric GISTOral presentation
- 第6回平成大腸癌カンファレンス, Japanese, 中外製薬株式会社, 神戸, Japan, Domestic conference大腸癌における外科治療Others
- 第20回 千葉消化管運動機能研究会, Japanese, 千葉大学大学院医学研究院 先端応用科学, 千葉, Japan, Domestic conference漢方を使う消化管集学的治療Public discourse
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference胃管癌に対する胸腔鏡手術の導入Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference腹腔鏡下胃切除術における術前後の大腰筋断面積変化の検討Poster presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要か;予防的頸部郭清省略の検討Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference食道癌に対する胸腔鏡下食道切除術、propensity scoreを用いた腹臥位と左側臥位の予後の比較Poster presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference胸壁前有茎空腸再建術の工夫と有用性Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference, Co-authored internationally腹腔鏡下噴門即胃切除後の食道胃管再建に関する検討Poster presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference胃癌に対する腹腔鏡下脾動脈近位即郭清における画像によるシミュレーションと左外側アプローチの有用性Poster presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference当科で術前化学療法を施行した腎機能障害を有する胃癌症例の検討Poster presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conferenceαガラクトシルセラミド付加した抗原導入した樹状細胞抗腫瘍ベクターの抗腫瘍効果Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference進行横行結腸癌に対する発生解剖に基づいた鏡視下手術:頭側アプローチのコツと工夫Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference食道がんに対する内視鏡下手術の進歩Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference消化器外科医に求められる大動脈食道瘻の手術治療戦略Oral presentation
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conference慢性腎臓病(CKD)の胃癌切除後の合併症発生に及ぼす影響Public symposium
- 第74回日本消化器外科学会総会, English, 東京慈恵会医科大学, 東京, Japan, Domestic conferenceStudy of morbidity and mortality in pancreaticoduodenectomy: Collaborative projects of NCD and NSQIPPublic symposium
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conferenceSafety of laparoscopic gastrectomy for gastric cancer in prospective cohort study using NCD registryPublic symposium
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学, 東京, Japan, Domestic conferenceThe utilization of 'Big Date' in gastroenterologocal surgeryOthers
- 第74回日本消化器外科学会総会, Japanese, 東京慈恵会医科大学/武田薬品工業株式会社, 東京, Japan, Domestic conferenceランチョンセミナー1 ゲノム医療で始まる大腸癌治療の新時代 ~外科医はどのように対処するのか~Others
- 神戸消化器外科懇話会分科会, Japanese, 株式会社大塚製薬工場/イーエヌ大塚製薬株式会社, 神戸, Japan, Domestic conference進行胃がんに対する集学的治療 ~ロボット手術から術後栄養管理まで~Others
- 第91回大腸癌研究会, Japanese, がん・感染症センター 都立駒込病院 外科, 東京, Japan, Domestic conference当院における大腸NETの手術治療成績Poster presentation
- 第91回大腸癌研究会, Japanese, がん・感染症センター 都立駒込病院 外科, 東京, Japan, Domestic conference示説Ⅰ-6 大腸癌肝転移の治療戦略Others
- 第91回大腸癌研究会, Japanese, がん・感染症センター 都立駒込病院 外科, 東京, Japan, Domestic conferenceモーニングセミナーA(MSA) 大腸がん補助療法の最新情報Others
- 第26回外科侵襲とサイトカイン研究会, Japanese, 神戸大学大学院医学研究科外科系講座 災害・救急医学分野, 神戸, Japan, Domestic conference術後腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討Public symposium
- 第15回近畿腹腔鏡下胃切除セミナー, Japanese, 近畿腹腔鏡下胃切除セミナー/コヴィディエンジャパン株式会社, 大阪, Japan, Domestic conference開会の挨拶Others
- 第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference直腸癌手術における術中内視鏡検査による吻合部評価の有用性Poster presentation
- 第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference食道癌における術前化学療法症例による免疫微小環境の変化Public symposium
- 第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference胸部食道癌に対し予防的頸部リンパ節郭清は全例に必要かPublic symposium
- 第28回日本癌病態治療研究会, Japanese, 埼玉医科大学総合医療センター 消化管・一般外科/ゲノム診療科, 川越, Japan, Domestic conference大腸癌病態からみた最新治療Others
- Colorectal Cancer Seminar~大腸がん治療の最新情報~, Japanese, メルクバイオファーマ株式会社, 福岡, Japan, Domestic conference最新のエビデンスをどの様に解釈し臨床へ応用するかNominated symposium
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference3Dモニターが手術操作にもたらす影響に関する術者技術レベルごとの検討Public symposium
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference術前化学療法として SOX 療法を施行した進行食道胃接合部癌の 4 例Oral presentation
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference女性外科医から始める働き方改革Public symposium
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference高齢者の胃癌切除におけるCONUT scoreによるフレイル判定の有用性Public symposium
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference3ステップ法による腹腔鏡下結腸脾弯曲授動Public symposium
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conference胸腔鏡下食道癌手術におけるエノキサパリンによる静脈血栓塞栓症予防Oral presentation
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conferenceワークショップ1「高難度手術チームの立ち上げ方」Others
- 第44回日本外科系連合学会学術集会, Japanese, 金沢医科大学 一般・消化器外科学, 金沢, Japan, Domestic conferenceランチョンセミナー2Others
- Computer Assisted Radiology and Surgery(CARS2019), English, Rennes, France, International conferenceThree-dimensional laparoscopic vision improves forceps motion more in the depth direction than in the horizontal directionPoster presentation
- 第41回日本癌局所療法研究会, Japanese, 川崎医科大学臨床腫瘍学, 岡山, Japan, Domestic conference虫垂腺癌術後の吻合部再発と診断され、神経内分泌癌と診断された1手術例Oral presentation
- 第41回日本癌局所療法研究会, Japanese, 川崎医科大学臨床腫瘍学, 岡山, Japan, Domestic conference高齢者の胃癌切除症例における術前末梢血中リンパ球数の臨床的意義Oral presentation
- 第41回日本癌局所療法研究会, Japanese, 川崎医科大学臨床腫瘍学, 岡山, Japan, Domestic conferenceランチョンセミナー 大腸癌治療へのMolecular Subtype〜MSIを含めてPublic discourse
- 第41回日本癌局所療法研究会, Japanese, 川崎医科大学臨床腫瘍学, 岡山, Japan, Domestic conference主題1 「がん局所療法とゲノム医療」Others
- 27th European Association for Endoscopic Surgery (EAES2019), English, Seville, Spain, International conferenceA new technique for lymph node dissection along proximal splenic artery during laparoscopic gastrectomy for gastric cancer: Left-lateral approach.Public symposium
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conferenceAll-trans-レチノイン酸はヒトiPS細胞から食道上皮への分化誘導を促進するPoster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference食道切除再建術における経腸栄養tube留置の意義Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference高齢食道癌患者に対する胸腔鏡手術の妥当性Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conferenceロボット支援下食道切除術の導入と初期治療成績Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference食道癌に対する胸腔鏡下食道切除術、腹臥位と左側臥位の予後の比較Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference当科での腹臥位胸腔鏡下食道切除術における上縦隔郭清手技と成績Poster presentation
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conferenceランチョンセミナー 8 食道胃接合部癌治療を考える ―よい手術、集学的治療と栄養管理―Others
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference27476例の食道切除術を用いた機能集約シミュレーション:NCDを活用した医療政策提言Public symposium
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference術後再発食道扁平上皮癌の転移巣に対する外科的切除の意義に関する全国実態調査Public symposium
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference“Seed and Soil”セッション5 研究推進の「土壌作り」に向けた食道学会の役割Others
- 第73回日本食道学会学術集会, Japanese, 独立行政法人国立病院機構 九州がんセンター, 福岡, Japan, Domestic conference化学・放射線療法の習得と集学的治療の実践Public symposium
- Nagoya GI symposium ~Final Circular~, Japanese, 日本イーライリリー株式会社, 名古屋, Japan, Domestic conference令和の胃癌治療戦略Public discourse
- 第29回日本サイトメトリー学会学術集会, Japanese, 順天堂大学医学部内科学血液学講座, 東京, Japan, Domestic conferenceαガラクトシルセラミド付加した抗原導入した樹状細胞ベクターの抗腫瘍効果Oral presentation
- 第29回日本サイトメトリー学会学術集会, Japanese, 順天堂大学医学部内科学血液学講座, 東京, Japan, Domestic conference腹膜播種マウスモデルにおける腹腔内骨髄由来抑制細胞(MDSC)の検討Oral presentation
- 第73回手術手技研究会, Japanese, 上尾中央総合病院 外科, 東京, Japan, Domestic conferenceTa-TME における「外側先行剥離」による安全な手術手技Oral presentation
- 第73回手術手技研究会, Japanese, 上尾中央総合病院 外科, 東京, Japan, Domestic conference胃1Public discourse
- 2019日中胃がん治療フォーラム, Japanese, 大鵬薬品工業株式会社, Beijing, China, International conference日本における胃癌の周術期治療の新たな進歩Others
- 第40回癌免疫外科研究会, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Japan, Domestic conference消化器癌患者の末梢血T細胞におけるimmunological synapseの評価Oral presentation
- 第40回癌免疫外科研究会, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Japan, Domestic conference直腸癌術前化学放射線療法における腫瘍免疫因子の発現動態の解析Oral presentation
- 第40回癌免疫外科研究会, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Japan, Domestic conferenceタンパク抗原を導入したNKT細胞活性化樹状細胞ワクチンベクターの抗腫瘍効果Oral presentation
- 第40回癌免疫外科研究会, Japanese, 金沢大学 消化器・腫瘍・再生外科学, 金沢, Japan, Domestic conference要望演題8 炎症・癌局所微小環境(2)Others
- 胃癌WEBライブセミナーin HYOGO, Japanese, プリストル・マイヤーズ スクイブ株式会社、小野薬品工業株式会社, 神戸, Japan, Domestic conferenceニボルマブの効果を引き出すためのベストプラクティスPublic discourse
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferenceEffect of hospital and surgeon volume on postoperative outcomes after total gastrectomy for gastric cancer based on Japanese nationwide databasePublic symposium
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferencePrediction of the dorsal landmark using 3D-CT during laparoscopic lymph node dissection along the proximal splenic artery in gastric cancerPoster presentation
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferenceImpact of Lymphatic Metastasis for the Recurrence of Adenocarcinoma of the Esophagogastric JunctionPoster presentation
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferenceThe long-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patientsPoster presentation
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferenceComparison of two- and three-dimensional display for performance of laparoscopic total gastrectomy for gastric cancerPoster presentation
- IGCC 2019 第13回国際胃癌学会議, English, Prague, Czech Republic, International conferencePhase III study of laparoscopic distal gastrectomy for advanced gastric cancer in Japan (JLSSG0901): results of short term outcomesPoster presentation
- 第44回 KSELS & 国際シンポジウム, English, The Korean Society of Endoscopic & Laparoscopic Surgeons, Seoul, Korea, Republic of, International conferenceRoutine Placement of Feeding Jejunostomy Tube during Thoracoscopic Esophagectomy Increases Postoperative Complications and Does Not Improve Postoperative MalnutritionPoster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference胸部食道癌手術において経腸栄養tube は全例に必要か?Poster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceミラーイメージの克服についての工夫 モニターの位置とカメラの角度についての検討Poster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference局所進行直腸癌に対する術前化学放射線療法と画像診断に基づく選択的側方郭清の治療Poster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference時代にマッチした若手消化器外科腹腔鏡トレーニングコースの開催Poster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference局所進行胃癌に対する術前化学療法におけるSOX 療法の安全性と有効性Poster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference肺への浸潤を伴う食道癌に対する胸腔鏡下食道切除術の試みPoster presentation
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference本邦における高齢者食道癌手術後に発生する手術関連死亡リスクの因子の解析-National Clinical Databaseを用いて-Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceCollaborative projects of NCD and NSQIP for quality improvement of gastroenterological surgeryPublic symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference腹腔鏡下胃切除術における術後大腰筋断面積変化の検討Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceTa-TMEにおける安全な神経血管束温存と直腸尿道筋切離のための工夫Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference高齢者胃癌後の肺炎併発による長期予後への影響の検討Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceNational Clinical Database (NCD) 膵癌登録の第1回予後調査Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceNCDを活用した外科領域の医療政策エビデンスの発信~食道切除術の機能集約に向けて~Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceNational clinical database (NCD) による膵全摘出の術後合併症リスクモデルNominated symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference3D-CTを用いた脾動脈幹近位リンパ節背側境界の術前シミュレーションの有用性Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の安全性に関する検討Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conference直腸癌術前化学放射線療法の免疫微小環境の変化とその予後因子の検討Public symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceワークショップ(18) 高齢者上部消化管癌に対する治療戦略Nominated symposium
- 第119回日本外科学会定期学術集会, Japanese, 一般社団法人日本外科学会, 大阪, Japan, Domestic conferenceランチョンセミナー(1) 大腸がん治療の潮流~忙しい外科医が押さえておくポイント~Others
- 第31回兵庫大腸癌治療研究会, Japanese, 兵庫大腸癌治療研究会、ミヤリサン製薬株式会社、大鵬薬品株式会社, 神戸, Japan, Domestic conference術前化学放射線療法後に切除し得た直腸癌術後骨盤内再発の1例Oral presentation
- 神戸消化器外科 Seminar, Japanese, テルモ株式会社, 神戸, Japan, Domestic conference特別講演 胃癌手術において合併症を限りなく0にするための方法Others
- 第91回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター 胃外科, 静岡, Japan, Domestic conference術前化学療法を行った進行胃癌症例での再発例の検討Poster presentation
- 第91回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター 胃外科, 静岡, Japan, Domestic conferenceSiewertⅡ型食道胃接合部癌に対する偽His角・Fornix形成食道胃管再建Poster presentation
- 第91回日本胃癌学会総会, Japanese, 静岡県立静岡がんセンター 胃外科, 静岡, Japan, Domestic conferenceNCDデータベースを用いた胃切除術後合併症に与えるhospital and surgeon volumeの影響Nominated symposium
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference免疫チェックポイント阻害薬の適用からみたマイクロサテライト不安定性検査の在り方Public symposium
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference末梢血myeloid derived suppressor cells(MDSC)は腫瘍の再発を反映するOthers
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference腹膜播種マウスモデルにおける腹腔内骨髄由来抑制細胞(MDSC)の検討Oral presentation
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference乳癌センチネルリンパ節におけるprogrammed death −1 発現に関する検討Others
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference直腸癌術前化学放射線療法の腫瘍免疫因子の発現動態の解析Oral presentation
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference食道扁平上皮癌における酸化ヌクレオチド浄化因子MTH1 発現の検討Oral presentation
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conference高齢進行胃癌患者における術前化学療法の安全性Oral presentation
- 第18回日本再生医療学会総会, Mar. 2019, Japanese, 鳥取大学大学院医学系研究科 機能再生医科学専攻 遺伝子医療学部門, 神戸, Domestic conferenceポスター発表 癌幹細胞他(座長)Others
- 第52回制癌剤適応研究会, Mar. 2019, Japanese, 神戸大学大学院医学研究科外科学講座食道胃腸外科学分野, 神戸, Domestic conferenceSOX2 陰性食道扁平上皮癌はSOX2 プロモーター領域のメチル化を伴う高悪性組織亜型であるOral presentation
- 第91回日本胃癌学会総会, Feb. 2019, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津, Domestic conference本邦における胃癌に対する腹腔鏡下手手術成績に関する後ろ向き調査研究Others
- 第91回日本胃癌学会総会, Feb. 2019, Japanese, 静岡県立静岡がんセンター 胃外科, 沼津, Domestic conferenceパネルディスカッション4 高齢者に対する胃癌治療(座長)Others
- 14TH ANNUAL ACADEMIC SURGICAL CONGRESS, Feb. 2019, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, ヒューストン, International conferenceSuperiority of esophageal reconstruction by pedicled jejunal flap with microvascular augmentation.Oral presentation
- 14TH ANNUAL ACADEMIC SURGICAL CONGRESS, Feb. 2019, English, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, ヒューストン, International conferenceSkeletal muscle loss in laparoscopic gastrectomy: differences between laparoscopic procedures.Oral presentation
- 第22回バイオ治療法研究会, Dec. 2018, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conference末梢T細胞のIS形成能の測定法の確立Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference腹腔鏡下胃切除症例における周術期抗血栓療法の安全性の検討Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference腹腔鏡下胃癌手術における術前CTを用いた難易度予測Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference腹臥位食道癌手術における気管分岐部郭清Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference腹臥位胸腔鏡下食道亜全摘術において食道・気管の位置関係が左上縦隔郭清手技に及ぼす影響Oral presentation
- Millennaial Seminar of GI Cancer, Dec. 2018, Japanese, 中外製薬株式会社, 神戸, Domestic conference特別講演2 進行再発大腸癌治療におけるBevacizumabの意義(座長)Others
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference当科における十二指腸腫瘍に対する腹腔鏡内視鏡合同手術Public symposium
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference進行胃癌に対する最適な集学的治療Public discourse
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference食道切除・胸骨後再建後の胃管癌に対して胸腔鏡下に胃管切除術を施行した1例Oral presentation
- 第22回バイオ治療法研究会, Dec. 2018, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conference消化器癌における術前療法による癌免疫微小環境の変化Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference胸腔鏡下食道切除術に対する3D内視鏡の導入は術後合併症を減少させるか?Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference基礎および臨床データが示す腹腔鏡下胃全摘術における3D内視鏡システムの有用性Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference一般演題146 食道悪性 郭清(司会)Others
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conference安全なTa-TMEの確立を目指して~当科の手術成績と工夫~Oral presentation
- 第22回バイオ治療法研究会, Dec. 2018, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conferenceマウス腹膜播種モデルにおける腹腔内骨髄由来免疫抑制細胞(MDSC)の推移Oral presentation
- 第31回日本内視鏡外科学会総会, Dec. 2018, Japanese, 一般社団法人日本内視鏡外科学会, 福岡, Domestic conferenceICGR15分値に基づく肝予備能からみた肝切除の術式・安全性評価:NCDデータを用いた解析Public symposium
- Millennaial Seminar of GI Cancer, Dec. 2018, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceClosing RemarksOthers
- 第19回神戸外科フォーラム, Nov. 2018, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference閉会の挨拶Others
- 第29回日本消化器癌発生学会総会, Nov. 2018, Japanese, 一般社団法人日本消化器癌発生学会, 東京, Domestic conference腹膜播種モデルにおける腹腔内骨骨髄由来抑制細胞(MDSC)の推移Oral presentation
- 第48回 胃外科・術後障害研究会, Nov. 2018, Japanese, 胃外科・術後障害研究会, 金沢, Domestic conference腹腔鏡下胃切除術における術前後の大腰筋断面積変化の検討Poster presentation
- 第27回日本コンピューター外科学会大会, Nov. 2018, Japanese, 一般社団法人日本コンピューター外科学会, 奈良, Domestic conference内視鏡手術による技術レベルごとの3D画像の影響Others
- JDDW2018(第26回日本消化器関連学会週間), Nov. 2018, Japanese, 一般社団法人 日本消化器関連学会機構, 神戸, Domestic conference内視鏡治療後非治癒切除症例に対する食道切除術の適応Others
- 第16回神戸消化器外科懇話会, Nov. 2018, Japanese, 神戸消化器外科懇話会/株式会社大塚製薬工業/イーエヌ大塚製薬株式会社, 神戸, Domestic conference特別講演Ⅱ 食道がん、食道胃接合部がん治療の展望~世界の趨勢とアジアの位置付け~(座長)Others
- 第19回神戸外科フォーラム, Nov. 2018, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference特別講演Ⅱ 上部消化器癌治療と栄養(司会)Others
- 第70回日本気管食道科学総会ならびに学術講演会, Nov. 2018, Japanese, 特定非営利活動法人 日本気管食道科学会, 東京, Domestic conference第9郡 食道癌(座長)Others
- 第29回日本消化器癌発生学会総会, Nov. 2018, Japanese, 日本消化器癌発生学会, 東京都, Domestic conference食道扁平上皮癌微小環境におけるFAP陽性癌関連線維芽細胞の役割Poster presentation
- 第29回日本消化器癌発生学会総会, Nov. 2018, Japanese, 一般社団法人日本消化器癌発生学会, 東京, Domestic conference食道癌患者におけるT細胞表面分子集簇による機能評価Poster presentation
- 第48回 胃外科・術後障害研究会, Nov. 2018, Japanese, 胃外科・術後障害研究会, 金沢, Domestic conference残胃癌に対する残胃亜全摘術の栄養状態の変化を含めた短期・長期成績に関する検討Others
- 神戸消化器がん免疫療法セミナー, Nov. 2018, Japanese, ブリストル・マイヤーズ スクイブ株式会社/小野薬品工業株式会社, 神戸, Domestic conference根治を目指すための胃がんの集学的治療Others
- オプジーボWEBライブセミナー, Nov. 2018, Japanese, ブリストル・マイヤーズ スクイブ株式会社/小野薬品工業株式会社, WEBセミナー, Domestic conference胃癌に対するニボルマルの有用性~ATTRACTION-2試験の長期フォローアップデータを踏まえて~(座長)Others
- 第29回 日本消化器癌発生学会総会, Nov. 2018, Japanese, 一般社団法人日本消化器癌発生学会, 東京, Domestic conferenceランチョンセミナー1 QOLを見据えた大腸癌化学療法~ポートポンプリー治療の実態~Others
- 第80回日本臨床外科学会総会, Nov. 2018, Japanese, 日本臨床外科学会, 東京, Domestic conferenceパネルディスカッション25 LECS~現在から未来へ~(司会)Others
- 第27回日本コンピューター外科学会大会, Nov. 2018, Japanese, 一般社団法人日本コンピューター外科学会, 奈良, Domestic conferenceセッションⅢ/画像2,ナビゲーション1,境界領域1(座長)Others
- JDDW2018(第26回日本消化器関連学会週間), Nov. 2018, Japanese, 一般社団法人 日本消化器関連学会機構, 神戸, Domestic conferenceInternational Session(Symposium)6 ロボットが切り開く消化器外科の未来 (司会)Others
- 第80回日本臨床外科学会総会, Nov. 2018, Japanese, 日本臨床外科学会, 東京, Domestic conferenceICGR15分値に基づく肝予備能からみた肝切除の術式・安全性評価:NCDデータを用いた解析Public symposium
- 神戸医療連携懇話会, Oct. 2018, Japanese, バイエル薬品株式会社, 神戸, Domestic conference兵庫県の消化器診療の再編と展望Others
- 第25回近畿内視鏡下大腸手術研究会, Oct. 2018, Japanese, 近畿内視鏡下大腸手術研究会/ジョンソンエンドジョンソン株式会社, 神戸, Domestic conference特別講演Ⅱ 直腸癌に対するロボット手術(座長)Others
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference特別企画シンポジウム 癌治療-Made in Japan 世界にはばたく日本発の癌治療- 次世代を担う免疫療法を目指して(司会)Others
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference高齢者胃癌の外科治療Oral presentation
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference学術セミナー34 大腸癌における最適な治療戦略(司会)Others
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference化学療法後に胃切除術を行った進行胃癌症例における予後因子の検討Poster presentation
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference胃癌治療の新潮流[Invited]Nominated symposium
- Chugai Colorectal Cancer Symposium in HYOGO, Oct. 2018, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceパネルディスカッション 患者さんの生活スタイル・嗜好を取り入れた治療選択Others
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceシンポジウム3 胃癌の集学的治療(司会)Others
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceがん診療ガイドラインの将来ー臓器がん登録の質と医療の質の向上を目指してーOthers
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceStage III結腸癌に対する術後補助化学療法C-SOX療法の効果・安全性の検討(KSCC1303)Oral presentation
- 第56回日本癌治療学会学術集会, Oct. 2018, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceStageIII胃癌における術後補助化療S-1+Docetaxel療法とS-1単独療法の第III相試験Oral presentation
- 第77回日本癌学会学術集会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conference本邦での大腸癌患者におけるマイクロサテライト不安定性検査の有用性についての検討Poster presentation
- 第31回近畿内視鏡外科研究会, Sep. 2018, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference腹臥位胸腔鏡下食道切除術における縦隔郭清の工夫と定型化Public symposium
- 第31回近畿内視鏡外科研究会, Sep. 2018, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference肥満症例に対する腹腔鏡下胃切除術~何が手術の難易度を規定するのか?~Public symposium
- 第31回近畿内視鏡外科研究会, Sep. 2018, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference当科におけるTa-TMEの導入と定型化Public symposium
- 第77回日本癌学会学術総会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conference直腸癌術前化学放射線療法によるCD8+T細胞とPD-L1陽性免疫細胞の誘導Oral presentation
- 日本消化器病学会近畿支部第109回例会, Sep. 2018, Japanese, 日本消化器病学会, 大阪, Domestic conference食道閉塞をきたし早期手術をおこなった酸性洗剤飲用による腐食性食道炎の一例Oral presentation
- 第31回近畿内視鏡外科研究会, Sep. 2018, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference食道切除・胸骨後再建後の胃管癌に対して胸腔鏡下に胃管切除術を施行した1例Oral presentation
- 第77回日本癌学会学術総会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conference腫瘍抗原導入DCGによる抗原特異的抗腫瘍免疫活性化Poster presentation
- 第11回神戸消化器癌勉強会, Sep. 2018, Japanese, 株式会社ヤクルト本社, 神戸, Domestic conference一般講演(座長)Others
- 第77回日本癌学会学術集会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conferenceランチョンセミナー18 ニューテクノロジーへの期待、がん免疫療法への予感(座長)Others
- 第77回日本癌学会学術集会, Sep. 2018, Japanese, 大阪, Domestic conferenceヒト乳がん異種移植モデルの微小転移がん幹細胞で発現低下しているマイクロRNA-25の解析Poster presentation
- 第17回兵庫胃がん治療研究会, Sep. 2018, Japanese, 大鵬薬品工業株式会社/兵庫胃がん治療研究会/兵庫県がん診療連携協議会, 神戸, Domestic conferenceセッションⅡ 化学療法 「胃癌治療のUp to Date」(司会)Others
- 第31回近畿内視鏡外科研究会, Sep. 2018, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conferenceスポンサードセッション2 ロボット手術を導入して~腹腔鏡との違いはこのポイント~(座長)Others
- 日本消化器病学会近畿支部第109回例会, Sep. 2018, Japanese, 日本消化器病学会, 大阪, Domestic conferenceシンポジウム1 消化管診療の最前線(司会)Others
- 第77回日本癌学会学術総会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conferenceT細胞刺激後免疫シナプス様表面分子の集簇反応の評価Poster presentation
- 第77回日本癌学会学術集会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conferenceSymposia on Specific Tumors 消化管がん治療の新展開(座長)Others
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferenceStagedPedicled Jejunal after Aortoesophagectomy for Aortoesophageal Fistula.Poster presentation
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferenceReliable Surgical Techniques for Lymphadenectomy along the Left Recurrent Laryngeal Nerve during Thoracoscipic Esophagectomy Iin the Prone Position.Others
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferencePseudodiverticulosis-Related Esophageal Mass with Intense Fdg UptakePoster presentation
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferenceProne Position in Thoracoscopic Esophagectomy Improves Postoperative Oxygenation and Reduces Pulmonary ComplicationsPoster presentation
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferencePlenary Session XII: New Horizons of Immuno-Oncology in Esophageal Cancer: Where We Are Now(座長)Oral presentation
- 第77回日本癌学会学術総会, Sep. 2018, Japanese, 日本癌学会, 大阪, Domestic conferenceIFT20は微小管ダイナミックスを制御することで大腸癌細胞の浸潤能亢進に寄与するPoster presentation
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferenceComparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal squamous cell carcinomaOral presentation
- The international society for Diseases of the Esophagus (ISDE), Sep. 2018, English, International Society for Diseases of the Esophagus, Vienna, International conferenceClinical Impact of Surgical Apgar Score in Predicting Postoperative Complications and Long-Term Prognosis after Esophagectomy.Poster presentation
- 地域医療連携を考える会, Aug. 2018, Japanese, 第一三共株式会社, 神戸, Domestic conference特別講演 抗血栓薬(抗凝固薬、抗血小板薬)をどう扱うか?~非循環器科医の先生方に知っておいていただきたい事~(座長)Others
- 第22回日本がん免疫学会総会, Aug. 2018, Japanese, 日本がん免疫学会, 岡山, Domestic conference消化器癌患者におけるT細胞の刺激応答性の評価方法の検討Poster presentation
- 日本外科代謝栄養学会第55回学術集会, Jul. 2018, Japanese, 日本外科代謝栄養学会, 大阪, Domestic conference要望演題3 重症感染症に対する至適栄養管理とは?(座長)Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference閉塞性大腸癌に対する術前大腸ステント留置の有用性の検討Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference腹腔鏡下側方リンパ節郭清を安全に行うための2つの筋膜を意識した手術手技Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference腹腔鏡下胃全摘術におけるOverlap法の工夫と検討Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference腹臥位胸腔鏡下食道切除術のlearning curveが術後合併症に及ぼす影響と今後の展望Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference難治性腹水に対する改良型腹水濾過濃縮再静注法(KM-CART療法)の治療効果Poster presentation
- 第30回神戸臨床腫瘍研究会, Jul. 2018, Japanese, 神戸臨床腫瘍研究会/中外製薬会社, 神戸, Domestic conference特別講演Ⅱ がん治療革命:遺伝子診療時代における外科治療(座長)Others
- 兵庫県消化器外科研究会2018, Jul. 2018, Japanese, 兵庫県消化器外科研究会/小野薬品工業株式会社, 神戸, Domestic conference特別講演 進行食道癌に対する総合的治療戦略(座長)Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference当院における腹腔鏡下胃全摘術についての検討Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference男性直腸癌Hartmann術後人工肛門閉鎖(再吻合)において術中内視鏡を活用し腹腔鏡手術を行った1例Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference切除可能進行胃癌における術前補助化学療法の予後因子の検討Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference食道癌術前化学療法の効果予測因子としての癌幹細胞マーカーの有用性に関する検討Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference消化器癌患者におけるT細胞表面分子集簇による機能評価Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference術前抗血栓療法中の胃切除患者に対する周術期抗血栓療法の検討Poster presentation
- 第27回日本がん転移学会学術集会・総会, Jul. 2018, Japanese, 日本がん転移学会, 横浜, Domestic conference術後腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討Public symposium
- 日本外科代謝栄養学会第55回学術集会, Jul. 2018, Japanese, 日本外科代謝栄養学会, 大阪, Domestic conference高齢者の胃癌治癒切除後の予後予測におけるCONUT scoreの有用性Oral presentation
- 日本外科代謝栄養学会第55回学術集会, Jul. 2018, Japanese, 日本外科代謝栄養学会, 大阪, Domestic conference高齢者における術前化学療法の安全性と栄養評価Oral presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference後期高齢者進行胃癌患者に対する術前化学療法の安全性Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference局所進行直腸癌に対する術前化学療法のランダム化Phase II試験とその免疫関連マーカーの解析 (KSCC1301A)Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference胸部食道癌手術において経腸栄養tube留置は省略できるか?Poster presentation
- 日本外科代謝栄養学会第55回学術集会, Jul. 2018, Japanese, 日本外科代謝栄養学会, 大阪, Domestic conference教育セミナー 消化器がん治療における漢方の役割(座長)Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference胃癌術後の合併症発生の予測因子としてのeGFRの有用性Poster presentation
- 第16回日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 公益社団法人 日本臨床腫瘍学会, 神戸, Domestic conferenceStageIII治癒切除胃癌に対する術後補助化学療法としてのS-1+Docetaxel併用療法とS-1単独療法のランダム化比較第III相試験Others
- 第5回平成大腸癌カンファレンス, Jul. 2018, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceSession2 大腸癌治療の最前線~2018 Update~(座長)Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conferencepT4b症例における腹腔鏡手術の治療成績Others
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conferenceKM-CARTにより原発性胆汁性胆管炎による難治性腹水の減少を認めた1例Poster presentation
- 第16回日本臨床腫瘍学会学術集会, Jul. 2018, Japanese, 公益社団法人 日本臨床腫瘍学会, 神戸, Domestic conferenceFlow cytometric measurement of erythrocyte membrane-bound IgG: A potential diagnostic method for colorectal carcinomaPoster presentation
- 第89回大腸癌研究会, Jul. 2018, Japanese, 大腸癌研究会, 新潟, Domestic conferencecT1大腸癌におけるESD穿孔症例の検討Poster presentation
- 第73回日本消化器外科学会総会, Jul. 2018, Japanese, 一般社団法人 日本消化器外科学会, 鹿児島, Domestic conference50周年特別企画2 春夏秋冬 心技の継承 胃Others
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conference鼠径リンパ節転移を伴う進行直腸癌に対する術前化学放射線療法と手術の制御効果Oral presentation
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference食道破裂の全国実態調査Others
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference食道原発神経内分泌腫瘍の病態に関わる全国調査Others
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference食道癌術前化学療法のchemoresistance markerとしてのCD24、CD44、CD133の有用性Poster presentation
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference食道Gastrointestinal stromal tumor(GIST)の病態に関わる全国調査Others
- 第16回日本ヘルニア学会学術集会, Jun. 2018, Japanese, 日本ヘルニア学会, 札幌, Domestic conference消化器外科におけるNCD登録とデータの利活用Public discourse
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conference高齢者胃癌患者における術後肺炎併発の長期予後への影響Public symposium
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference研究推進委員会報告(司会)Others
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference胸部食道癌手術において経腸栄養tubeは全例に必要か?Poster presentation
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conference胸腔鏡下食道切除術後の合併症の予後Poster presentation
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conferenceランチョンセミナー6 酸関連疾患の四半世紀の変遷、 今後の胃酸分泌抑制剤の戦略(座長)Others
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conferenceマルチライフ~女性外科医と家庭の真の両立を目指して~Public symposium
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conferenceビデオシンポジウム 新たなMIEを求めて~3D手術の進歩~(司会)Others
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conferenceビデオシンポジウム5 明日から活かせる腹腔鏡下胃全摘後の再建術(座長)Others
- Colorectal Cancer Seminar~大腸がん治療の最新情報~, Jun. 2018, Japanese, メルクセローノ株式会社, 福岡, Domestic conferenceパネルディスカッション 最新のエビデンスをどの様に解釈し臨床へ応用するか(司会)Others
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conferenceQOLに考慮した有茎空腸再建術の工夫Others
- 第72回日本食道学会学術集会, Jun. 2018, Japanese, 特定非営利活動法人 日本食道学会, 宇都宮, Domestic conferenceMIEにおいて3D内視鏡システムは反回神経麻痺を減少させるか?Others
- 2018 ASCO Annual Meeting, Jun. 2018, English, 2019アメリカ臨床腫瘍学会(ASCO), Chicago, International conferenceA randomized phase III study comparing S-1 plus docetaxel with S-1 alone as a postoperative adjuvant chemotherapy for curatively resected stage III gastric cancer (JACCRO GC-07 trial).Oral presentation
- 第43回日本外科系連合学会学術集会, Jun. 2018, Japanese, 一般社団法人 学会支援機構内日本外科系連合学会事務局, 東京, Domestic conference3D/HDおよび2D/4Kモニターが内視鏡外科医の手術手技にもたらす効果Public symposium
- 第6回がんと代謝研究会, May 2018, Japanese, がんと代謝研究会, 奄美大島, Domestic conference放射線がもたらす腫瘍微小環境の変化の解析Poster presentation
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference肺への浸潤を伴う食道癌に対する胸腔鏡下食道切除術Others
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference当科におけるTa-TMEの手術手技と手術成績Others
- 第201回近畿外科学会, May 2018, Japanese, 近畿外科学会事務局, 大阪, Domestic conference当院における十二指腸LECSの検討Oral presentation
- 第27回日本癌病態治療研究会, May 2018, Japanese, NPO法人 日本癌病態治療研究会事務局, 千葉, Domestic conference直腸癌術前化学療法の腫瘍免疫因子の発現動態の解析Public symposium
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference直腸癌手術における術中内視鏡検査と経肛門ドレーンの有効性Others
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference進化する胃癌治療Public discourse
- 第28回日本サイトメトリー学会学術集会, May 2018, Japanese, 一般社団法人日本サイトメトリー学会, 東京, Domestic conference消化器癌患者におけるT細胞の刺激応答性の新規評価方法Poster presentation
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference十二指腸腫瘍に対す腹腔鏡内視鏡合同手術についてPoster presentation
- 第39回癌免疫外科研究会, May 2018, Japanese, 癌免疫外科研究会, 岐阜, Domestic conference腫瘍再発モデルにおける末梢血中の骨髄由来抑制細胞(MDSC)の推移Oral presentation
- 第6回がんと代謝研究会, May 2018, Japanese, がんと代謝研究会, 奄美大島, Domestic conference腫瘍再発モデルにおける末梢血中の骨髄由来抑制細胞(MDSC)の推移Poster presentation
- 第39回癌免疫外科研究会, May 2018, Japanese, 癌免疫外科研究会, 岐阜, Domestic conference主題Ⅱ Precision Medicineの幕開け(司会)Poster presentation
- 第201回近畿外科学会, May 2018, Japanese, 近畿外科学会事務局, 大阪, Domestic conference酸性洗剤飲用により完全閉塞をきたした腐食性食道炎の一例Oral presentation
- 第201回近畿外科学会, May 2018, Japanese, 近畿外科学会事務局, 大阪, Domestic conference左結腸動脈温存D3郭清の定型化:当院での試みOral presentation
- 第27回日本癌病態治療研究会, May 2018, Japanese, NPO法人 日本癌病態治療研究会事務局, 千葉, Domestic conference癌患者におけるT細胞の刺激応答性の評価Others
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conference開腹Hartmann術後の人工肛門形成状態に対する腹腔鏡下人工肛門閉鎖術の有効性Poster presentation
- 第27回日本癌病態治療研究会, May 2018, Japanese, NPO法人 日本癌病態治療研究会事務局, 千葉, Domestic conferenceイブニングセミナー マイクロRNAの臨床応用を目指してOthers
- 第72回手術手技研究会, May 2018, Japanese, 手術手技研究会事務局, 徳島, Domestic conferenceSurgical Forum14 食道②(司会)Others
- 第201回近畿外科学会, May 2018, Japanese, 近畿外科学会事務局, 大阪, Domestic conferenceFDGの高度集積を認めた食道偽憩室に起因する食道腫瘤の一例Oral presentation
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference腹壁瘢痕ヘルニアinlay-meshにおける腹腔鏡手術と開腹手術の比較Poster presentation
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference腹臥位での胸腔鏡手術による食道癌根治術Oral presentation
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference第2部 第5回「臨床研究助成」及び「若手外科医のための臨床研究助成」授賞式(司会)Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference多施設共同観察研究による食道扁平上皮癌術前治療における効果予測分子バイオマーカーの同定(KSCC1307)Public symposium
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference食道癌内視鏡的粘膜下層剥離術後非治療切除症例に対する追加治療例の検討Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference食道癌手術における合併症および長期予後予測因子としてのSurgical Apgar ScorePublic symposium
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference高齢者進行胃癌に対する術前化学療法の安全性Poster presentation
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference高齢者の胃癌治癒切除後の予後予測因子におけるCONUT scoreの有用性Public symposium
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference胸腔鏡下食道切除術に対する3D内視鏡の導入と治療成績Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conference下部進行直腸癌に対する術前化学放射線療法+選択的側方郭清の治療成績Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conferenceワークショップ(3) 胃切除後障害に対する対策(司会)Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conferenceランチョンセミナー(27) 胃癌に対する手術と化学療法の新展開(司会)Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conferenceランチョンセミナー(11) がん免疫療法が切り開く外科医の未来(司会)Others
- AACR Annual Meeting 2018, Apr. 2018, English, American Association for Cancer Research, Chicago, International conferenceThe induction of PD-L1 positive immune cells and CD8-positive T lymphocytes by neoadjuvant chemoradiotherapy for rectal cancerPoster presentation
- SAGES2018, Apr. 2018, English, Society of American Gastrointestinal and Endoscopic Surgeons, Washington, International conferenceSurgical strategy for splenic flexure cancer.Others
- 第118回日本外科学会定期学術集会, Apr. 2018, Japanese, 一般社団法人日本外科学会, 東京, Domestic conferenceNCDによるReal Wordデータが腹腔鏡下幽門側胃切除の実臨床を変える可能性Others
- AACR Annual Meeting 2018, Apr. 2018, English, American Association for Cancer Research, Chicago, International conferenceFlow cytometric measurement of increased erythrocyte bound IgG: A potential screening method for colorectal cancerPoster presentation
- AACR Annual Meeting 2018, Apr. 2018, English, American Association for Cancer Research, Chicago, International conferenceEpigenetic regulation of colorectal cancer stem cells by the miR-221/QKI5 axis.[Invited]Invited oral presentation
- AACR Annual Meeting 2018, Apr. 2018, English, American Association for Cancer Research, Chicago, International conferenceElectroporation as a feasible method for antigen delivering into vectors loaded with NKT cell ligandPoster presentation
- AACR Annual Meeting 2018, Apr. 2018, English, American Association for Cancer Research, Chicago, International conferenceA new method for evaluating T cell response after stimulation on gastrointestinal cancer patientsPoster presentation
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conference乳癌センチネルリンパ節におけるprogrammed death-1発現に関する検討Oral presentation
- 神戸 消化器外科 Seminar, Mar. 2018, Japanese, テルモ株式会社, 神戸, Domestic conference特別講座Others
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference当科での腹腔鏡下胃全摘術における食道空腸吻吻合の短期成績に関する検討Poster presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference当院における残胃癌に対する腹腔鏡手術の検討Poster presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference神経内分泌細胞成分を伴う胃癌に対する集学的治療の有用性Poster presentation
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conference術前化学放射線療法を施行した進行直腸癌におけるmodified Glassgow Prognostic Scoreを用いた治療効果予測Oral presentation
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conference高齢者食道癌における術前補助化学療法についての検討Oral presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference高齢者の胃癌切除症例における術前末梢血の総リンパ球数の臨床的意義Oral presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference高齢者の胃癌切除後の予後予測における血小板/リンパ球比の有用性Oral presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference口演4 高齢者胃癌Others
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conference局所進行直腸癌における術前化学放射線療法後の免疫細胞の解析Oral presentation
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conference化学療法後に胃切除術を行った進行胃癌症例の検討Oral presentation
- 神戸胃がん免疫療法セミナー, Mar. 2018, Japanese, ブリストル・マイヤーズ スクイズ株式会社,小野薬品工業株式会社, 神戸, Domestic conference胃癌における免疫チェックポイント阻害薬(仮)Public discourse
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conferenceワークショップ5 新しい胃癌取扱い規約(15版)に基づいた補助化学療法の成績Others
- 第51回制癌剤適応研究会, Mar. 2018, Japanese, 制癌剤適応研究会, 下呂, Domestic conferenceStageIV胃癌に対するconversion surgeryの適応と予後の検討Oral presentation
- 第90回日本胃癌学会総会, Mar. 2018, Japanese, 日本胃癌学会, 横浜, Domestic conference80歳以上の胃癌患者に対する術前補助化学療法の経験Poster presentation
- 第14回日本消化管学会総会学術集会, Feb. 2018, Japanese, 日本消化管学会, 東京, Domestic conference発生と解剖に基づいた脾弯曲癌に対する腹腔鏡下結腸間膜全切除Public symposium
- 第14回日本消化管学会総会学術集会, Feb. 2018, Japanese, 日本消化管学会, 東京, Domestic conference当科における噴門部GISTの手術成績と治療戦略の検討Public symposium
- 第14回日本消化管学会総会学術集会, Feb. 2018, Japanese, 日本消化管学会, 東京, Domestic conference大腸癌薬物療法の新展開Others
- 兵庫大腸癌治療フォーラム2018, Feb. 2018, Japanese, 武田薬品工業株式会社, 神戸, Domestic conference大腸癌集学的治療の展開Others
- Chugai Colorectal Cancer Symposium in Kobe, Feb. 2018, Japanese, 中外製薬株式会社, 神戸, Domestic conference大腸癌がん化学療法の新潮流2018[Invited]Invited oral presentation
- 第14回日本消化管学会総会学術集会, Feb. 2018, Japanese, 日本消化管学会, 東京, Domestic conference神経内分泌細胞成分を含む胃癌に対する集学的治療の有用性Public symposium
- 第14回日本消化管学会総会学術集会, Feb. 2018, Japanese, 日本消化管学会, 東京, Domestic conference下部消化管癌に対する内視鏡外科手術Others
- 消化器がん免疫療法セミナー, Feb. 2018, Japanese, 小野薬品株式会社,ブリストル・マイヤーズ スクイブ株式会社, 神戸, Domestic conferenceがん免疫療法の有効性と使いこなすための工夫~肺癌治療の経験から~[Invited]Invited oral presentation
- 第17回神戸がん研究会, Jan. 2018, Japanese, 神戸がん研究会,日本イーライリリー株式会社, 神戸, Domestic conference特別講演I 消化器癌におけるPD-L1発現調整と免疫療法[Invited]Invited oral presentation
- Cancer VTEセミナー~がんと静脈血栓塞栓症~, Jan. 2018, Japanese, 第一三共株式会社, 神戸, Domestic conference講演I、講演IIPublic discourse
- 第37回兵庫臨床栄養研究会, Jan. 2018, Japanese, 兵庫臨床栄養研究会,EAファーマ株式会社,株式会社陽進堂, 神戸, Domestic conference開会の辞Others
- 第37回兵庫臨床栄養研究会, Jan. 2018, Japanese, 兵庫臨床栄養研究会,EAファーマ株式会社,株式会社陽進堂, 神戸, Domestic conference『胃がん周術期の管理を支える栄養の役割』Others
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 日本内視鏡外科学会, 京都, Domestic conference腹臥位食道癌手術における左右上縦隔郭清Public symposium
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 日本内視鏡外科学会, 京都, Domestic conference進行胃癌に対する腹腔鏡下胃切除術の短期、長期成績 開腹術との比較Public symposium
- 第21回バイオ治療法研究会学術集会, Dec. 2017, Japanese, バイオ治療研究会, 福岡, Domestic conference術後腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討Oral presentation
- 第21回バイオ治療法研究会学術集会, Dec. 2017, Japanese, バイオ治療研究会, 福岡, Domestic conference腫瘍抗原導入DCGを用いた抗原特異的抗腫瘍免疫活性化Oral presentation
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 日本内視鏡外科学会, 京都, Domestic conference高齢者食道癌に対する胸腔鏡下手術成績の検討Poster presentation
- 第17回日本クリニカルパス学会, Dec. 2017, Japanese, 日本クリニカルパス学会, 大阪, Domestic conference外国人患者受入れ医療機関認証制度と患者用クリニカルパスPoster presentation
- 第18回日本クリニカルパス学会学術集会, Dec. 2017, Japanese, 日本クリニカルパス学会, 大阪, Domestic conference外国人患者受入れ医療機関認証制度と患者用クリニカルパスOral presentation
- 第30回日本内視鏡外科学会総会, Dec. 2017, Japanese, 日本内視鏡外科学会, 京都, Domestic conference横行結腸癌に対する腹腔鏡下手術における発生学的観点からみた至適切除範囲とアプローチ法についてPoster presentation
- Millennnial Seminar of GI Cancer, Dec. 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conference胃がん治療の方向性Others
- 2017年度生命科学系学会合同年次大会ConBio, Dec. 2017, English, 日本分子生物学会、日本生化学会, 兵庫(神戸), Domestic conferenceヒト大腸上皮の分化過程における腫瘍抑制的マイクロRNAの協調的発現上昇Poster presentation
- Millennnial Seminar of GI Cancer, Dec. 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceClosing RemarksOthers
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference理事直轄プロジェクトOthers
- 神戸外科フォーラム, Nov. 2017, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference理事直轄プロジェクトOthers
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本臨床外科学会, 東京, Domestic conference直腸癌術前化学放射線療法の腫瘍免疫因子の発現動態の解析[Invited]Nominated symposium
- 神戸大腸癌治療セミナー, Nov. 2017, Japanese, バイエル薬品株式会社, 神戸, Domestic conference大腸癌化学療法 Late lineを再考するOthers
- 第28回日本消化器癌発生学会総会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference食道扁平上皮癌微小環境におけるFAP陽性癌関連線維芽細胞の役割Poster presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本臨床外科学会, 東京, Domestic conference食道・胃癌術前補助療法CR症例[手術 vs 経過観察][Invited]Nominated symposium
- 第47回胃外科・術後障害研究会, Nov. 2017, Chinese, 胃外科・術後研究会, 横浜, Domestic conference上部胃癌に対する至適な切除術式と再建法[Invited]Nominated symposium
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference消化器癌患者におけるT細胞の刺激応答性の評価方法の検討Oral presentation
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference術後腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討Oral presentation
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference腫瘍再発モデルにおける末梢血中の骨髄由来抑制細胞(MDSC)の推移Oral presentation
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference腫瘍抗原導入DCGを用いた抗腫瘍免疫活性化の検討Oral presentation
- 第47回胃外科・術後障害研究会, Nov. 2017, Japanese, 胃外科・術後研究会, 横浜, Domestic conference高齢者進行胃癌症例治療成績からみた戦略Poster presentation
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本臨床外科学会, 東京, Domestic conference高齢者の胃癌切除後における炎症に基づく予後予測スコアの有用性Oral presentation
- 日本放射線腫瘍学会第30回学術大会, Nov. 2017, Japanese, 日本放射線腫瘍学会, 大阪, Domestic conferenceExperience of Neoadjuvant Chemoradiotherapy for locally advanced rectal cancerOral presentation
- 第28回日本消化器癌発生学会, Nov. 2017, Japanese, 日本消化器癌発生学会, 熊本, Domestic conference癌微小環境における腫瘍関連マクロファージ由来のCXCL8はヒト食道扁平上皮癌の運動能および浸潤能を促進するOthers
- 第28回日本消化器癌発生学会総会, Nov. 2017, English, 日本消化器癌発生学会, 熊本, Domestic conferenceCXCL8 derived from TAMs promotes cell migration and invasion of human esophageal cancer cells[Invited]Invited oral presentation
- 第1回神戸消化器学術講演会, Nov. 2017, Japanese, ミヤリサン製薬株式会社, 神戸, Domestic conference開会挨拶Others
- 第1回神戸消化器学術講演会, Nov. 2017, Japanese, ミヤリサン製薬株式会社, 神戸, Domestic conference『大腸癌鏡視下手術における発生と解剖に基づいたアプローチ』Others
- 第79回日本臨床外科学会総会, Nov. 2017, Japanese, 日本臨床外科学会, 東京, Domestic conferenceStage IV胃癌に対するconversion surgeryの適応と治療成績Public symposium
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference閉塞性大腸癌に対する術前大腸ステント留置の有用性の検討Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference内視鏡的粘膜下層剥離術後非治癒切除症例に対する食道切除の意義とその役割Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference大腸ESD後穿孔症例に対するクリッピング閉鎖の有効性についてPoster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference早期胃癌に対するESD後の追加外科切除症例の検討Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference進化する胃癌周術期化学療法[Invited]Invited oral presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference食道切除術におけるSurgical Apgar Scoreの有用性の検討Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference高齢者食道癌における術前補助化学療法の検討Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference高齢者食道癌における胸腔鏡下手術に関する検討(優秀演題)Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference高齢者胃癌の術後合併症発生の予測因子としてのCONUT scoreの有用性Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference高齢者の胃癌切除症例における術前末梢血の白血球系細胞数の臨床的意義Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference高齢者の胃癌切除後における炎症に基づく予後予測スコアの有用性Oral presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conference回腸双孔式人工肛門閉鎖における創部線状縫合閉鎖と巾着縫合閉鎖の比較Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference医師主導臨床試験グループが果たす役割:KSCCにおける取り組み[Invited]Nominated symposium
- 第55回日本癌治療学会学術集会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference胃癌腹膜播種に対しての化学療法[Invited]Nominated symposium
- 第55回日本癌治療学会学術集会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference胃がん治療のパラダイムシフト ~がん免疫療法の到来~Public discourse
- Chugai Colorectal Cancer Symposium in HYOGO, Oct. 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conference『大腸癌のOS延長を目指した最適な治療戦略とは?(仮)』[Invited]Invited oral presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conferenceStage IV胃癌への新たな治療戦略Poster presentation
- JDDW2017, Oct. 2017, Japanese, 日本消化器関連学会機構, 福岡, Domestic conferenceStage IV胃癌に対するconversion surgeryの適応と治療成績Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conferenceHER2陽性胃癌に対するトラスツズマブ併用療法の多施設共同コホート研究(KSCC1105)Poster presentation
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conferencecStageII/III胃癌に対する術前化学療法の有用性Poster presentation
- JDDW2017, Oct. 2017, English, 日本消化器関連学会機構, 福岡, Domestic conferenceClinical outcomes of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for lower rectal cancerPublic symposium
- 第55回日本癌治療学会学術総会, Oct. 2017, Japanese, 日本癌治療学会, 横浜, Domestic conference70歳以上の結腸・直腸癌患者に対するTFTD(TAS-102)とBevacizumabの第II相臨床試験Public discourse
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference膵臓側に局在が及ぶ十二指腸腫瘍に対する腹腔鏡・内視鏡合同手術Public symposium
- 大腸癌フォーラム in Hyogo 2017, Sep. 2017, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference閉会の挨拶Others
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference腹腔鏡下食道亜全摘術を施行した食道炎症性腫瘤の1例Oral presentation
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference腹腔鏡下胃切除後にPetersen's herniaをきたした3例Oral presentation
- 第10回神戸消化器癌勉強会, Sep. 2017, Japanese, 株式会社ヤクルト, 神戸, Domestic conference特別講演 進行再発大腸癌の化学療法~マネージメントのコツ~[Invited]Invited oral presentation
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference当科におけるTAMIS併用直腸癌手術の経験と今後の課題Public symposium
- 第76回日本癌学会学術総会, Sep. 2017, Japanese, 日本癌学会, 横浜, Domestic conference低酸素環境におけるMCM7 mRNA発現レベルの乖離Poster presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 近畿外科学会, 京都, Domestic conference術前診断し腹腔鏡下小腸部分切除術をおこなった小腸血管腫の1例Oral presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 近畿外科学会, 京都, Domestic conference術前化学放射線療法を施行した局所進行肛門管癌に対して有茎腹直筋皮弁再建が有用であった1例Oral presentation
- 第16回兵庫胃がん治療研究会, Sep. 2017, Japanese, 兵庫胃がん治療,兵庫県がん診療連携協議会,大鵬薬品株式会社, 神戸, Domestic conference開会挨拶Others
- 第200回近畿外科学会, Sep. 2017, Japanese, 近畿外科学会, 京都, Domestic conference回腸ストマ閉鎖における創部環状閉鎖と線上閉鎖との比較Oral presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 近畿外科学会, 京都, Domestic conference炎症性食道腫瘤の1例Oral presentation
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference「観察性能の進化がもたらす最新の手術手技~腹腔鏡下消化管手術のUp to Date~」[Invited]Invited oral presentation
- 第76回日本癌学会学術総会, Sep. 2017, Japanese, 日本癌学会, 横浜, Domestic conferenceヒト上皮分化プログラムの解析に基づく癌幹細胞抑制マイクロRNAの固定Oral presentation
- 第30回近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conferenceイレウス症状を呈し腹腔鏡下に切除した小腸神経内分泌腫瘍の1例Oral presentation
- 第200回近畿外科学会, Sep. 2017, Japanese, 近畿外科学会, 京都, International conferenceアフタヌーンセミナー「進歩する胃がんの治療」[Invited]Invited oral presentation
- 第76回日本癌学会学術総会, Sep. 2017, Japanese, 日本癌学会, 横浜, Domestic conferencemiR-221-QKI5経路による大腸癌幹細胞の制御機構の解明Oral presentation
- 第76回日本癌学会学術総会, Sep. 2017, Japanese, 日本癌学会, 神奈川(横浜), Domestic conferencemiR-221-QKI5 axis regulates tumorigenicity of human colorectal cancer stem cellsOral presentation
- 第76回日本癌学会学術総会, Sep. 2017, English, 日本癌学会, 神奈川(横浜), Domestic conferenceIdentification of cancer-stem-cell-suppressor microRNAs through the analyses of human epithelial differentiation programOral presentation
- 第76回日本癌学会学術総会, Sep. 2017, Japanese, 日本癌学会, 神奈川(横浜), Domestic conferenceDiscordance of MCM7 mRNA and its intronic microRNA levels under hypoxiaPoster presentation
- 兵庫大腸癌治療フォーラム, Sep. 2017, Japanese, 武田薬品, 神戸, Domestic conferenceClosing LectureOthers
- 6th Reduced Port Surgery Forum 2017 in Oita、第11回 単孔式内視鏡手術研究会、第17回 Needlescopic Surgery Meeting, Aug. 2017, Japanese, 単孔式内視鏡手術研究会, 大分, Domestic conference右側結腸癌に対するReduced port Surgeryの短期成績についてOral presentation
- 日本・モンゴル国際消化器がんシンポジウム, Aug. 2017, English, 中山がん研究所, ウランバートル, モンゴル, International conferenceOutcomes and prognostic factors of selective lateral pelvic lymph node dissection with preoperative chemoradiotherapy for locally advanced rectal cancerOral presentation
- 日本・モンゴル国際消化器がんシンポジウム, Aug. 2017, English, 中山がん研究所, ウランバートル, モンゴル, International conferenceLaparoscopic complete mesocolic excision for splenic flexure cancer based on embryologyOral presentation
- 日本・モンゴル国際消化器がんシンポジウム, Aug. 2017, English, 中山がん研究所, ウランバートル, モンゴル, Domestic conferenceComparison of two-and three-dimensional display for performance of laparoscopic total gastrectomy for gastric cancerOral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference要望演題19(1) 消化器疾患に関する最新の臨床研究1Others
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference本邦における胃癌に対する腹腔鏡下手術成績に関する後ろ向き調査研究[Invited]Invited oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference閉塞性大腸癌に対するステント留置の有用性Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference腹腔鏡下幽門側胃切除術における術前CT画像を用いた手術時間を予測する簡便な指標に関する検討Oral presentation
- Meet the Professor on Gastric Cancer, Jul. 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conference特別講演「胃癌治療の最近の話題と今後の展望」Others
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference当院における進行下部直腸癌に対する側方リンパ節郭清についてPublic symposium
- 第4回平成大腸癌カンファレンス, Jul. 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conference大腸癌に対する周術期化学療法Others
- 第87回大腸癌研究会, Jul. 2017, Japanese, 大腸癌研究会, 四日市, Domestic conference大腸ESD後穿孔症例に対するクリッピング閉鎖の有効性の検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference食道癌手術におけるSurgical Apgar Scoreと合併症予測因子Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference食道癌cStageII/IIIで術前補助化学療法を施行した症例におけるCRP/Albの有用性Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference消化器外科関連分野のNCDの現状と展望[Invited]Invited oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference消化器外科におけるNCDを活用した研究課題の成果と今後の展開[Invited]Invited oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference術前抗血栓療法中の胃切除患者に対する周術期抗血栓療法の検討Oral presentation
- 第87回大腸癌研究会, Jul. 2017, Japanese, 大腸癌研究会, 四日市, Domestic conference術前化学放射線療法施行直腸癌における免疫関連因子の発現動態の検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference周術期腹膜炎に伴う免疫抑制メカニズムの解明と治療:マウスモデルでの検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference高齢者胃癌手術後の予後予測におけるCONUT scoreの有効性Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference血管吻合付有茎空腸再建術の工夫と治療成績Public symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference局所進行直腸癌における術前化学放射線療法後のPD-L1発現の変化Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference胸腔鏡下食道切除術における術後合併症と予後との検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, English, 日本消化器外科学会, 金沢, Domestic conferenceThe role of cancer microenvironment in growth, invasion, and metastasis of cancer[Invited]Nominated symposium
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference癌微小環境における腫瘍関連マクロファージ由来のIL-8はヒト食道扁平上皮癌の運動能および浸潤能を促進するOral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference化学療法施行後に手術を行った高度進行胃癌の検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference胃GISTに対するLECS(laparoscopy and endoscopy cooperative surgery)により切除された胃壁長の検討Oral presentation
- 第72回日本消化器外科学会総会, Jul. 2017, Japanese, 日本消化器外科学会, 金沢, Domestic conference「患者負担の少ない癌手術と化学療法へのサポーティブケア」[Invited]Invited oral presentation
- 第26回日本がん転移学会学術集会・総会, Jul. 2017, Japanese, 日本がん転移学会, 大阪, Domestic conferenceランチョンセミナー 胃癌・大腸癌における血管新生のメカニズムと治療[Invited]Invited oral presentation
- 第15回日本臨床腫瘍学会学術集会, Jul. 2017, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conferenceポスター Colorectal Cancer3 大腸3Others
- 第15回日本臨床腫瘍学会学術集会, Jul. 2017, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conferenceExpression of programmed death-1 (PD-1) in sentinel lymph nodes of breast cancerOral presentation
- 第71回日本食道学会学術集会, Jun. 2017, Japanese, 日本食道学会, 軽井沢, Domestic conference腹腔鏡下食道癌手術手技の施設内統一と成績Poster presentation
- 第26回癌病態治療研究会, Jun. 2017, Japanese, 日本癌病態治療研究会, 横浜, Domestic conference内視鏡的粘膜下層剥離術後非治療切除症例に対する食道切除の意義とその役割Public symposium
- 第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conference大腸がん幹細胞におけるマイクロRNA-221の特異的発現Oral presentation
- 第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conference人工癌幹細胞と癌オルガノイドを用いた癌幹細胞研究[Invited]Nominated symposium
- 第71回日本食道学会学術集会, Jun. 2017, Japanese, 日本食道学会, 軽井沢, Domestic conference食道非上皮性腫瘍の術前診断とその有用性Public symposium
- 第71回日本食道学会学術集会, Jun. 2017, Japanese, 日本食道学会, 軽井沢, Domestic conference食道癌同時性重複癌症例に対する同時手術治療症例の検討Poster presentation
- 第42回日本外科系連合学会学術集会, Jun. 2017, Japanese, 日本外科系連合学会, 徳島, Domestic conference食道癌手術における呼吸器合併症の低減を目指したmultidisciplinary team manegementPublic symposium
- 第26回癌病態治療研究会, Jun. 2017, Japanese, 日本癌病態治療研究会, 横浜, Domestic conference術前化学放射線療法を施行した進行直腸癌におけるmodified Glasgow Prognostic Scoreを用いた治療効果予測Public symposium
- 第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conference腫瘍抗原導入DCGを用いた抗腫瘍免疫活性化の検討Oral presentation
- 第39回日本癌局所療法研究会, Jun. 2017, Japanese, 日本癌局所療法研究会, 京都, Domestic conference主題「再発癌に対する局所療法」Others
- 第71回日本食道学会学術集会, Jun. 2017, Japanese, 日本食道学会, 軽井沢, Domestic conference高齢者食道癌に対する腹腔鏡下手術の治療成績の検討Poster presentation
- 第60回関西胸部外科学会学術集会, Jun. 2017, Japanese, 日本胸部外科学会, 大阪, Domestic conference高齢者食道癌に対する鏡視下手術の役割Others
- 第60回関西胸部外科学会学術集会, Jun. 2017, Japanese, 日本胸部外科学会, 大阪, Domestic conference高齢者食道癌に対する胸腔鏡下手術の治療成績の検討Public symposium
- 第26回癌病態治療研究会, Jun. 2017, Japanese, 日本癌病態治療研究会, 横浜, Domestic conference局所進行直腸癌術前化学放射線療法の免疫チェクポイント分子の変化Public symposium
- 第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conference教育講演「個別化がん医療に向けたヒト腫瘍モデルの新たな展開」Public discourse
- 第71回日本食道学会学術集会, Jun. 2017, Japanese, 日本食道学会, 軽井沢, Domestic conference一般演題 口演1 頭頸部食道癌の治療Others
- 第26回癌病態治療研究会, Jun. 2017, Japanese, 日本癌病態治療研究会, 横浜, Domestic conference「Conversion surgeryの適応と治療成績」Others
- 第42回日本外科系連合学会学術集会, Jun. 2017, Japanese, 日本外科系連合学会, 徳島, Domestic conferenceワークショップ4 多施設共同研究を進めるためのチームネットワークOthers
- 第39回日本癌局所療法研究会, Jun. 2017, Japanese, 日本癌局所療法研究会, 京都, Domestic conferenceTmab+XP療法が著効しConversion surgeryを施行した胃癌腹膜播種の一例Oral presentation
- 第26回癌病態治療研究会, Jun. 2017, Japanese, 日本癌病態治療研究会, 横浜, Domestic conferenceStage IV胃癌に対するConversion surgeryの適応と治療成績Public symposium
- 第25回欧州内視鏡外科会議(EAES), Jun. 2017, English, EAES, フランクフルト, ドイツ, International conferenceSingle incision laparoscopic colectomy for colon cancer in a patient with situs inversus totalis;A case reportPoster presentation
- 第39回日本癌局所療法研究会, Jun. 2017, Japanese, 日本癌局所療法研究会, 京都, Domestic conferenceS-1/CDDP療法後に手術を施行し長期予後を得ている腹膜播種陽性胃癌の1例Oral presentation
- 第25回欧州内視鏡外科会議(EAES), Jun. 2017, English, EAES, フランクフルト, ドイツ, International conferenceNext generation laparoscopic surgery using EMARO(Endoscopic Manipulator Robot)and a 3D endoscope systemPoster presentation
- 第25回欧州内視鏡外科会議(EAES), Jun. 2017, English, EAES, フランクフルト, ドイツ, International conferenceEmbryological consideration of laparoscopic completeOral presentation
- 第25回欧州内視鏡外科会議(EAES), Jun. 2017, English, EAES, フランクフルト, ドイツ, International conferenceComparison of operative skill using two -and three-dimensional monitor during laparoscopic phantom tasks by the position trackerPoster presentation
- 第27回日本サイトメトリー学会学術集会, Jun. 2017, Japanese, 日本サイトメトリー学会, 神戸, Domestic conferenceB16F10細胞を用いた再発モデルにおける末梢血中MDSCの経時的測定の有用性Oral presentation
- ASCO2017 ANNUAL MEETING, Jun. 2017, Japanese, ASCO, シカゴ, アメリカ, Domestic conferenceA randomized phase II study evaluating efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy for patients with resectable rectal cancer(KSCC1301).(abstract3549)Poster presentation
- 第71回手術手技研究会, May 2017, Japanese, 手術手技研究会, 名古屋, Domestic conference鉗子操作の3次元軌跡解析を用いた内視鏡外科手術の適正評価法の開発と技術評価が学習効果に及ぼす影響に関する研究Others
- Gastric Cancer Symposium in Kobe, May 2017, Japanese, 中外製薬株式会社, 神戸, Domestic conference腹腔鏡下胃癌手術~術後化学療法の実践までOthers
- 神戸大腸がんセミナー, May 2017, Japanese, メルクセローノ株式会社, 神戸, Domestic conference特別講演「九州大学第二外科における臨床と研究」[Invited]Invited oral presentation
- 第38回癌免疫外科研究会, May 2017, Japanese, 癌免疫外科研究会, 倉敷, Domestic conference直腸癌における腫瘍免疫関連因子の発現動態と化学療法前後の腫瘍浸潤CD8陽性T細胞の発現の変化と組織学的効果判定の関連の検討Oral presentation
- 第38回癌免疫外科研究会, May 2017, Japanese, 癌免疫外科研究会, 倉敷, Domestic conference胆癌状態における腫瘍誘導性骨髄由来抑制細胞(MDSC)を与える影響Oral presentation
- 第71回手術手技研究会, May 2017, Japanese, 手術手技研究会, 名古屋, Domestic conference大動脈食道瘻手術における消化器外科医の役割‐食道切除と再建を中心に‐Oral presentation
- 第38回癌免疫外科研究会, May 2017, Japanese, 癌免疫外科研究会, 倉敷, Domestic conference穿孔性腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討Oral presentation
- 第71回手術手技研究会, May 2017, Japanese, 手術手技研究会, 名古屋, Domestic conference進行横行結腸癌に対する頭側アプローチによる腹腔鏡下拡大結腸右半切除術Oral presentation
- 第117回日本外科学会定期学術集会, May 2017, Japanese, 日本外科学会, 神戸, Domestic conference上部消化管の高悪性度神経内分泌腫瘍 26例の検討Others
- 第71回手術手技研究会, May 2017, Japanese, 手術手技研究会, 名古屋, Domestic conference十二指腸腫瘍に対する腹腔鏡内視鏡合同手術‐当科における手技の工夫と治療成績‐Oral presentation
- 第38回癌免疫外科研究会, May 2017, Japanese, 癌免疫外科研究会, 倉敷, Domestic conference腫瘍抗原導入DCGを用いた抗原特異的な抗腫瘍免疫活性化Oral presentation
- 第38回癌免疫外科研究会, May 2017, Japanese, 癌免疫外科研究会, 倉敷, Domestic conference癌局所微小環境(主題II)[Invited]Nominated symposium
- 神戸大学消化器癌セミナー, May 2017, Japanese, 日本イーライリリー株式会社, 神戸, Domestic conferenceClosing Remarks[Invited]Invited oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference腹腔鏡下幽門側胃切除術における簡便な手術難易度を示す指標に関する検討Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference腹腔鏡下右側結腸切除術においてReduced Port Surgeryをいかに教育するか?Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference腹腔鏡下S状結腸・直腸癌における下腸間膜動脈high ligationの重要性Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference動作解析システムを用いた3D腹腔鏡下での手術手技の検討Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference当院における腹腔鏡下胃全摘術における食道空腸吻合法の検討Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference直腸癌の術前化学放射線療法施行例における免疫関連因子の検討Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference担癌状態におけるmyeloid derived suppressor cellsの治療による変化と治療成績への影響Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference大腸ESD後穿孔症例に対するクリッピング閉鎖の有用性についてPoster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference大腸ESD後穿孔症例に対するクリッピング閉鎖の有効性についてOral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference食道癌手術のパラダイム・シフト-側臥位から腹臥位へ-Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference食道胃接合部癌Siewert II型に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と逆流防止を意識した偽His角・fornix形成を伴う食道胃管吻合法Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference食道・胃接合部癌の集学的治療Others
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference消化器外科医からみた大動脈食道瘻の治療戦略Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference根治切除を施行したpStageII-III胃癌に対するS-1術後補助化学療法Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference高齢者食道癌に対する術前補助化学療法の治療成績Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference呼吸器合併症低減をめざした食道癌手術とmultidisciplinary team managementPoster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference血流に配慮した食道再建術の工夫Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胸腔鏡下食道癌手術症例における術後合併症の発生と予後の検討Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference患者左右から攻略する腹腔鏡下膵上縁D2郭清Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference下部直腸癌の鼠径リンパ節転移に対する術前化学放射線療法の有用性Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胃癌肝転移の外科治療の問題点Oral presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胃癌ESD後の腹腔鏡下胃切除による追加治療Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胃・十二指腸腫瘍に対するLECS(laparoscopy and endoscopy cooperative surgery)Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference胃GISTに対する腹腔鏡下胃切除の有用性Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conferenceランチョンセミナー(30)胃癌薬物療法の課題と展望Others
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conferenceディベート(3)cStageI上部胃癌の術式選択-噴門部胃切除 vs 胃全摘-Others
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conferenceStage IV胃癌に対するConversion surgeryの適応Poster presentation
- Annual Meeting of the American Association for Cancer Research 2017, Apr. 2017, English, American Association for Cancer Research, Washington DC, USA, International conferenceDetection of EBV BamHI W region in surgical cancer specimens is a useful method to evaluate the risk of lymphomagenesis inpatient derived-tumor xenograft.Poster presentation
- 第117回日本外科学会定期学術集会, Apr. 2017, Japanese, 日本外科学会, 横浜, Domestic conference3Dモニターが初心者の内視鏡外科修練にもたらす影響Oral presentation
- Annual Meeting of the American Association for Cancer Research 2017, Apr. 2017, English, American Association for Cancer Research, Washington DC, USA, International conference3D culture may better represent trastuzumab resistance associated with PIK3CA mutation than 2D culture.Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, Japanese Gastric Cancer Association, 広島, Domestic conference直接接触相互作用によるスキルス胃癌細胞の浸潤と間質線維芽細胞の増殖促進Poster presentation
- 第50回制癌剤適応研究会, Mar. 2017, Japanese, 制癌剤適応研究会, 徳島, Domestic conference大腸癌肝転移に対する術前化学療法の効果とその予後Oral presentation
- 第50回制癌剤適応研究会, Mar. 2017, Japanese, 制癌剤適応研究会, 徳島, Domestic conference局所進行直腸癌における術前化学放射線療法の免疫関連因子への影響Public symposium
- 第89回日本胃癌学会総会, Mar. 2017, English, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceThe significance of surgery following chemotherapy for stage IV gastric cancer (StageIV胃癌に対する化学療法後の外科切除の意義)Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceThe laparoscopic lymphadenectomy along proximal splenic artery from patient's left side(患者左から攻略する腹腔鏡下脾動脈近位側郭清)Others
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceThe cancer-stromal interaction in scirrhous-type gastric carcinoma(直接接触相互作用によるスキルス胃癌細胞の浸潤と間質線維芽細胞の増殖促進)Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceSurveillance and treatment for gastric cancer after radical esophagectomy(当科における食道切除後再建胃管癌の検討)Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferencePostoperative pneumonia after gastrectomy for elderly gastric cancer patients(高齢者胃癌の術後肺炎の長期予後に及ぼす影響)Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceLecture Series 2 Genome and epigenomeOthers
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceLECS(laparoscopy and endoscopy cooperative surgery) for gastric GIST(胃・十二指腸腫瘍に対するLECS(laparoscopy and endoscopy cooperative surgery)Oral presentation
- 第50回制癌剤適応研究会, Mar. 2017, Japanese, 制癌剤適応研究会, 徳島, Domestic conferenceHER2陽性乳癌細胞株を用いたPIK3CA変異によるtrastuzumab耐性機構に関する2次元、3次元培養の比較Public symposium
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceEarly gastric cancer accompanied by Menetrier's disease with difficulty in pueoperative diagnosis(術前進行度診断が困難であったMenetrier病合併早期胃癌の一例)Poster presentation
- 第89回日本胃癌学会総会, Mar. 2017, Japanese, 一般社団法人 日本胃癌学会, 広島, Domestic conferenceClinicopathologic Study of Gastric Stump Cancer after Proximal Gastrectomy(噴門側胃切除術後の残胃の癌の特徴)Poster presentation
- 第49回胃病態機能研究会, Feb. 2017, Japanese, 胃病態機能研究会, 名古屋, Domestic conference主題1-1 H.pylori 陰性・除菌後胃癌の特徴と治療Others
- 第49回胃病態機能研究会, Feb. 2017, Japanese, 胃病態機能研究会, 名古屋, Domestic conference高齢者の胃癌切除症例における術前末梢血の白血球系細胞数の臨床的意義Oral presentation
- 第49回胃病態機能研究会, Feb. 2017, Japanese, 胃病態機能研究会, 名古屋, Domestic conference後期高齢者の胃癌切除術後の呼吸器合併症発生の危険因子についての検討Oral presentation
- 第13回日本消化管学会総会学術集会, Feb. 2017, Japanese, 日本消化管学会, 名古屋, Domestic conference一般演題1 食道(治療)Others
- 第13回日本消化管学会総会学術集会, Feb. 2017, Japanese, 日本消化管学会, 名古屋, Domestic conferenceHER2陽性胃癌に対するTrastuzumabを併用した集学的治療Public symposium
- 第86回大腸癌研究会, Jan. 2017, Japanese, 大腸癌研究会, 盛岡, Domestic conference腹腔鏡下直腸低位前方切除術を安全に施行するための工夫Oral presentation
- 第9回日本ロボット外科学会学術集会, Jan. 2017, Japanese, J-robo 日本ロボット外科学会 事務局, 佐賀, Domestic conferenceロボット支援幽門側胃切除術における助手ポートからの超音波凝固切開装置使用の有用性Oral presentation
- 第9回日本ロボット外科学会学術集会, Jan. 2017, Japanese, J-robo 日本ロボット外科学会 事務局, 佐賀, Domestic conferenceEMARO(Endoscope Manipulate Robot)と3D内視鏡による次世代の腹腔鏡下手術についてOral presentation
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference腹腔鏡下直腸癌手術における3D内視鏡の有用性Oral presentation
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference腹腔鏡下中結腸動静脈郭清における出血をさせないための工夫Oral presentation
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference高齢者胃癌に対する腹腔鏡下胃切除術の手術成績の検討Oral presentation
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference胸腔鏡下食道切除術に対する3D内視鏡の有用性と治療成績Oral presentation
- 第20回バイオ治療法研究会学術集会, Dec. 2016, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 博多, Domestic conference外科切除のmyeloid derived suppressor cellsに対する影響と臨床的意義Oral presentation
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference【消化器外科 上部消化管】こだわりの手術手技~出血はしない、させない、ひろげない~2Others
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conferenceSiewert TypeII型食道胃接合部腺癌に対するロボット支援下経裂孔的下縦隔郭清の有用性Public symposium
- 第29回日本内視鏡外科学会総会, Dec. 2016, Japanese, 一般社団法人 日本内視鏡外科学会, 横浜, Domestic conference3ステップ法による腹腔鏡下脾弯曲授動の定型化Oral presentation
- 第24回日本消化器関連学会週間(JDDW2016), Nov. 2016, Japanese, JDDW 2016 運営委員会, 神戸, Domestic conference発生学的観点から見た横行結腸切除の特殊性・困難性と、安全・確実に腹腔鏡下D3横行結腸切除を行うための工夫Public symposium
- 第71回日本大腸肛門病学会学術集会, Nov. 2016, Japanese, 日本大腸肛門病学会事務局, 三重, Domestic conference直腸癌の術前化学放射線療法の免疫関連因子の検討Oral presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conference超高齢者胃癌に対する胃切除術の適応Public symposium
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conference大腸癌肝転移切除後の再発例に対する再発巣切除の意義Oral presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conference進行食道疣状扁平上皮癌の1例Oral presentation
- 第68回日本気管食道科学会, Nov. 2016, Japanese, 日本食道科学会, 東京, Domestic conference食道癌術後胃管壊死により胃管気管支瘻を来した1例Oral presentation
- 第24回日本消化器関連学会週間(JDDW2016), Nov. 2016, Japanese, JDDW 2016 運営委員会, 神戸, Domestic conference十二指腸乳頭部癌におけるKRAS遺伝子変異の臨床病理組織学的意義Poster presentation
- 第71回日本大腸肛門病学会学術集会, Nov. 2016, Japanese, 日本大腸肛門病学会事務局, 三重, Domestic conferenceランチタイムセミナー10 Evidenceを考慮した進行再発大腸癌の治療戦略Others
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conferenceビデオワークショップ08 胃全摘空腸パウチ再建術の有用性とコツOthers
- 第24回日本消化器関連学会週間(JDDW2016), Nov. 2016, Japanese, JDDW 2016 運営委員会, 神戸, Domestic conferenceシンポジウム8 腹腔下手術とロボット手術《ビデオ》[Invited]Invited oral presentation
- 第24回日本消化器関連学会週間(JDDW2016), Nov. 2016, Japanese, JDDW 2016 運営委員会, 神戸, Domestic conferenceサテライトシンポジウム90 エビデンスから実臨床へ-胃癌二次治療におけるRAM+PTX療法の経験から-Others
- 第24回日本消化器関連学会週間(JDDW2016), Nov. 2016, Japanese, JDDW 2016 運営委員会, 神戸, Domestic conferenceSOX2-negative squamous cell carcinoma of the esophagus: A rare variant with aggressive clinical coursesPoster presentation
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conferenceNCDから見えてくる消化器外科医療[Invited]Invited oral presentation
- 2016年アジア太平洋消化器週間(APDW 2016), Nov. 2016, English, 一般社団法人 日本消化器外科学会, 神戸, Domestic conferenceDigital Poster,Lower GI "Neoplasia 1"Others
- 2016年アジア太平洋消化器週間(APDW 2016), Nov. 2016, English, 一般社団法人 日本消化器外科学会, 神戸, Domestic conferenceCurrent Status and Future Directions for Gastric Cancer Treatment StrategyPublic discourse
- 第78回日本臨床外科学会総会, Nov. 2016, Japanese, 日本臨床外科学会 事務局, 東京, Domestic conference3D映像が内視鏡外科手術トレーニングに及ぼす影響の検討Oral presentation
- 第46回胃外科・術後障害研究会, Oct. 2016, Japanese, 胃外科・術後障害研究会, 米子, Domestic conference術前抗血栓療法中の胃切除患者に対する周術期抗血栓療法の検討Oral presentation
- 第54回日本癌治療学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference高齢者の胃癌切除後の呼吸器合併症への予後への影響についての検討Public symposium
- 第46回胃外科・術後障害研究会, Oct. 2016, Japanese, 胃外科・術後障害研究会, 米子, Domestic conference後期高齢者に対する胃癌切除術後の呼吸器合併症発生の危険因子の検討Oral presentation
- 第54回日本癌治療学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conference学術セミナー20 CVポート、インフューーザーポンプ自由自在Others
- 第46回胃外科・術後障害研究会, Oct. 2016, English, 胃外科・術後障害研究会, 米子, Domestic conference一般演題10〔高度進行・再発胃癌の治療〕Others
- 第54回日本癌治療学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceミニシンポジウム27 胃6:胃がんにおける新たな予後因子の探索Others
- 第54回日本癌治療学会学術集会, Oct. 2016, Japanese, 一般社団法人 日本癌治療学会, 横浜, Domestic conferenceStageIV胃癌に対する外科切除例の予後規定因子に関する検討Public symposium
- 第75回日本癌学会学術総会, Oct. 2016, Japanese, 日本癌学会, 横浜, Domestic conferenceSelectively upregulated miR-221 regulates the clonogenicity of human colon cancer stem cells(選択的に発現上昇しているマイクロ RNA-221 がヒト大腸がん幹細胞のクローン原性を制御する)Poster presentation
- 第75回日本癌学会学術総会シンポジウムS12 Advances in cancer animal model: from mechanisms to clinical output がん動物モデルの新展開:メカニズムから臨床応用まで, Oct. 2016, English, 日本癌学会, 横浜, Domestic conferenceSelectively upregulated miR-221 regulates the clonogenicity of human colon cancer stem cells.Poster presentation
- The 75th Annual Meeting of the Japanese Cancer Association, Oct. 2016, English, The Japanese Cancer Association, 神奈川(横浜), Domestic conferenceSelectively upregulated miR-221 regulates the clonogenicity of human colon cancer stem cells.Poster presentation
- 第15回日本心臓血管発生研究会, Oct. 2016, Japanese, 日本心臓血管発生研究会, 吹田, 血管内皮増殖因子(VEGF-A)は血管新生や血管透過性亢進に重要な役割を果たす。VEGF-Aヘテロ欠損(VEGF-A+/-)マウスやVEGF-A過剰発現マウスは血管や心臓の形成異常で胎生致死となることから、VEGF-Aの量的変化が個体発生に影響を与えることが知られている。VEGF-Aには二つのチロシンキナーゼ型受容体があり、Flk1が主要なシグナルを伝えるのに対して、Flt1はVEGF-Aの局所濃度を負に制御するデコイ受容体である。我々は、Flt1+/-マウスが一過性の胎仔浮腫をきたすことを見出し、胎生期の脈管形成及び体液恒常性維持におけるFlt1の制御的役割について解析した。Flt1のチロシンキナーゼ領域が欠損しているマウス胎仔は浮腫を示さず、Flt1+/-マウス胎仔ではFlk1のチロシンリン酸化が亢進していた。このことからFlt1シグナルではなく, Domestic conferenceFlt1/VEGFR1 heterozygosity causes transient embryonic edema in miceOral presentation
- 第75回日本癌学会学術総会, Oct. 2016, Japanese, 日本癌学会, 横浜, Domestic conferenceEvaluation of the risk of lymphomagenesis in xenografts by the detection of EBV BamHI W region in patient specimens.(患者検体からのEBウイルスBamHI W 領域の検出によるヒト腫瘍異種移植マウスのリンパ腫形成リスクの評価)Oral presentation
- The 75th Annual Meeting of the Japanese Cancer Association, Oct. 2016, Japanese, The Japanese Cancer Association, 神奈川(横浜), Domestic conferenceEvaluation of the risk of lymphomagenesis in xenografts by the detection of EBV BamHI W region in patient specimensOral presentation
- 第75回日本癌学会学術総会, Oct. 2016, Japanese, 日本癌学会, 横浜, Domestic conferenceBiomarker of esophageal cancer 食道癌のバイオマーカーOthers
- 40th World Congress of the International College of Surgeons/62nd Annual Congress of the International College of Surgeons Japan Section(第40回国際外科学会・第62回国際外科学会日本部会総会), Oct. 2016, English, 国際外科学会日本部会, 京都, International conferenceAdvances of diagnosis&treatment in gastrointestinal surgeryOthers
- 第46回胃外科・術後障害研究会, Oct. 2016, Japanese, 胃外科・術後障害研究会, 米子, Domestic conference80歳以上の高齢者胃癌に対する腹腔鏡下胃切除術の手術成績の検討Oral presentation
- 第29回近畿内視鏡外科研究会, Sep. 2016, Japanese, 近畿内視鏡外科研究会事務局, 京都, Domestic conference腹臥位食道癌手術における左上縦隔郭清の定型化Public symposium
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conference直腸癌の術前化学放射線療法施行例における免疫関連因子の検討Oral presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conference担癌状態における骨髄由来抑制細胞(MDSC)の治療による変化とその治療成績への影響Oral presentation
- 第25回消化器疾患病態治療研究会, Sep. 2016, Japanese, 消化器疾患病態治療研究会, 高崎市, International conference神経内分泌細胞成分を伴う胃癌に対する集学的治療の有用性Oral presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conference食道扁平上皮癌における酸化ヌクレオチド浄化因子MTH1発現の意義Poster presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conference手術治療をおこなった食道GISTの2例Oral presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conference癌微小環境における腫瘍関連マクロファージ由来のIL-8はヒト食道扁平上皮癌の運動能および浸潤能を促進するOral presentation
- 第25回消化器疾患病態治療研究会, Sep. 2016, Japanese, 消化器疾患病態治療研究会, 高崎市, International conference胃GIST に対するLECS(laparoscopy and endoscopy cooperative surgery)の検討Oral presentation
- 第29回近畿内視鏡外科研究会, Sep. 2016, Japanese, 近畿内視鏡外科研究会事務局, 京都, Domestic conference胃GISTに対するLECS(laparoscopy and endoscopy cooperative surgery)症例の検討Public symposium
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conferenceランチョンセミナー4 胃癌の病因の治療戦略Public discourse
- 第29回近畿内視鏡外科研究会, Sep. 2016, Japanese, 近畿内視鏡外科研究会事務局, 京都, Domestic conferenceランチョンセミナー1 腹腔鏡下大腸切除についてOthers
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conferenceHER2陽性胃癌に対するTrastuzumab併用化学療法後の外科切除の安全性と有効性Oral presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conferenceDOGにおけるCD40-CD40L interaction の抗腫瘍効果への影響Oral presentation
- 第27回日本消化器癌発生学会総会, Sep. 2016, Japanese, 日本消化器癌発生学会, 鹿児島, Domestic conferenceAllogeneic DCGを用いた抗腫瘍免疫活性化の検討Oral presentation
- 第29回近畿内視鏡外科研究会, Sep. 2016, Japanese, 近畿内視鏡外科研究会事務局, 京都, Domestic conference3ステップ法による腹腔鏡下結腸脾弯曲授動Oral presentation
- 第29回近畿内視鏡外科研究会, Sep. 2016, Japanese, 近畿内視鏡外科研究会事務局, 京都, Domestic conference3Dモニターが初心者の内視鏡外科トレーニングにもたらす影響Public symposium
- 第10回単孔式内視鏡手術研究会/第14回 Needlescopic Surgery Meeting, Aug. 2016, Japanese, 単孔式内視鏡手術研究会事務局, 大阪, Domestic conference右側結腸癌に対する単孔式腹腔鏡下手術の有用性についてOral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference鉗子軌跡解析による3D 映像の内視鏡手術における有用性の検討と今後の展開Public symposium
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference末梢血骨髄由来抑制細胞(MDSC)による再発予測Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference兵庫県における腹腔鏡下大腸癌手術の現状・兵庫大腸がん治療研究会のアンケート結果よりPoster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference噴門側胃切除術における偽His角・Fornix形成を行った食道胃管Overlap吻合法の有用性Poster presentation
- 第70回日本食道学会学術集会, Jul. 2016, Japanese, 特定非営利活動法人 日本食道学会, 東京, Domestic conference腹臥位食道癌手術におけるlearning curveと次世代の術者教育Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference当院における大腸ESD穿孔後の外科的治療の検討Poster presentation
- 第26回日本サイトメトリー学会学術集会, Jul. 2016, Japanese, 日本サイトメトリー学会, 福岡, Domestic conference担癌状態における腫瘍誘導性骨髄由来抑制細胞(MDSC)の与える影響と治療による変化Oral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference大腸癌内視鏡切除後の追加外科切除例におけるリンパ節転移のリスク因子Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference進行直腸癌におけるmodified Glasgow Prognostic Scoreを用いた治療効果予測Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference食道扁平上皮癌における酸化ヌクレオチド浄化因子MTH1発現の意義の検討Poster presentation
- 第70回日本食道学会学術集会, Jul. 2016, Japanese, 特定非営利活動法人 日本食道学会, 東京, Domestic conference食道非上皮性腫瘍の診断と手術治療の検討Public symposium
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference消化器外科医からみた大動脈食道瘻の治療戦略 -その食道切除術と再建術-Public symposium
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference術前抗血栓療法中の患者に対する胃切除症例の検討Poster presentation
- 第25回日本がん転移学会学術集会・総会, Jul. 2016, Japanese, 日本がん転移学会事務局, 米子, Domestic conference腫瘍に対する外科的切除の腫瘍誘導性骨髄由来抑制細胞(MDSC)に対する影響とその臨床的意義Poster presentation
- 第70回日本食道学会学術集会, Jul. 2016, Japanese, 特定非営利活動法人 日本食道学会, 東京, Domestic conference合併症提低減と根治性を目指した胸腔鏡下食道切除術の現況Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference高齢者胃癌に対する胃切除後の呼吸器合併症の予後に及ぼす影響Poster presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference高齢者Stage III進行大腸癌に対する補助化学療法における腹腔鏡手術の有用性Poster presentation
- 第85回大腸癌研究会, Jul. 2016, Japanese, 大腸癌研究会, 大阪, Domestic conference後期高齢者大腸癌に対する腹腔鏡手術の有用性Oral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference胸壁前経路有茎空腸再建術の有用性Public symposium
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference教育企画5 匠の技の継承「胃」Others
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference画像診断による腹腔鏡下側方リンパ節郭清の適応と神経筋膜を意識した郭清手技についてOral presentation
- 第26回日本サイトメトリー学会学術集会, Jul. 2016, Japanese, 日本サイトメトリー学会, 福岡, Domestic conference一般演題2「癌幹細胞/細胞増殖・転移浸潤マーカー」Others
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conference胃GISTに対するLECS(laparoscopy and endoscopy cooperative surgery)により余剰切除された胃壁長の検討Poster presentation
- 第85回大腸癌研究会, Jul. 2016, Japanese, 大腸癌研究会, 大阪, Domestic conference【アフタヌーンセミナーB】大腸癌化学療法~10年間の歩みと今後の展望~Others
- 第70回日本食道学会学術集会, Jul. 2016, Japanese, 特定非営利活動法人 日本食道学会, 東京, Domestic conferenceワークショップ3「食道非上皮性腫瘍の治療」Others
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conferenceランチョンセミナー5 胃がん周術期化学療法 -最新の知見と展望-Others
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conferenceパネルディスカッション1 胃切除後の食道再建術式Others
- The Japanese Society of Medical Oncology 2016 Annual Meeting, Jul. 2016, Japanese, The Japanese Society of Medical Oncology, 兵庫(神戸), Domestic conferenceUpregulation of Oncogenic miR-221 in Human Colon Cancer Stem Cells[Invited]Nominated symposium
- 第14回日本臨床腫瘍学会学術集会, Jul. 2016, Japanese, 日本臨床腫瘍学会, 神戸, Domestic conferenceOral Session 2-10 Gastric Cancer (2)Others
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conferenceNCDを活用した消化器外科医療の展開[Invited]Invited oral presentation
- 第26回日本サイトメトリー学会学術集会, Jul. 2016, Japanese, 日本サイトメトリー学会, 福岡, Domestic conferencealpha-galactosylceramideによるNKT細胞活性化と肝傷害Oral presentation
- 第26回日本サイトメトリー学会学術集会, Jul. 2016, Japanese, 日本サイトメトリー学会, 福岡, Domestic conferenceAllogeneic DCG療法を用いた抗腫瘍免疫活性化の検討Oral presentation
- 第71回日本消化器外科学会総会, Jul. 2016, Japanese, 一般社団法人 日本消化器外科学会, 徳島, Domestic conferenceAllogeneic DCG療法を用いたNKT細胞の活性化に伴う抗腫瘍降下の検討Poster presentation
- 第25回日本癌病態治療研究会, Jun. 2016, Japanese, NPO法人 日本癌病態治療研究会事務局, 東京, Domestic conference分子標的薬による胃癌の個別化治療Public symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference腹腔鏡下直腸切除術における縫合不全対策について -当科での工夫-Public symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference腹腔鏡下胃癌手術における層構造を意識した脾動脈近位側リンパ節郭清Public symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference腹臥位食道癌手術におけるエネルギーデバイスの使い分けとコツPublic symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference当科における腹腔鏡下直腸切除術における使用エネルギーデバイスについてPublic symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference直腸癌化学放射線療法後の腹会陰式直腸切断術における骨盤大網形成術の有用性Public symposium
- 第25回日本癌病態治療研究会, Jun. 2016, Japanese, NPO法人 日本癌病態治療研究会事務局, 東京, Domestic conference直腸癌の術前治療の現状と今後における癌免疫関連因子の検討Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference大腸癌肝転移切除後の再発巣に対する切除の意義Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference食道癌手術における気管支動脈3D-CT術前ナビゲーションの有用性Public symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference食道癌に対するMinimally Invasive EsophagectomyPublic symposium
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference高齢者大腸癌患者に対する腹腔鏡下手術の有用性の検討Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference高齢者の胃癌切除後の予後規定因子の検討Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference高齢者 Stage III進行大腸癌に対する補助化学療法の腹腔鏡手術における有用性Poster presentation
- 第38回日本癌局所療法研究会, Jun. 2016, Japanese, 日本癌局所療法研究会, 東京, Domestic conference下部直腸癌・肛門管癌に対する術前化学放射線療法施行後リンパ節郭清の治療成績Oral presentation
- 第38回日本癌局所療法研究会, Jun. 2016, Japanese, 日本癌局所療法研究会, 東京, Domestic conference一般演題 胃1Others
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference胃GISTに対する単孔式腹腔鏡下胃部分切除術の手術成績と手技の工夫Others
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conference胃GISTに対するLECS(laparoscoopy and endoscopy cooperative surgery)の検討Poster presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conferenceスポンサードシンポジウム(2) 外科学 各診療科の低侵襲手術の最前線Others
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conferenceStage IV胃癌に対する外科切除例の予後規定因子に関する検討Poster presentation
- 24th International congress of the European Association for Endoscopic Surgery, Jun. 2016, English, The European Association for Endoscopic Surgery, Amsterdam, The Netherlands, International conferenceLaparoscopic right hemicolectomy using a cranial approach: Technical tipsOral presentation
- 第41回日本外科系連合学会学術集会, Jun. 2016, Japanese, 日本外科系連合学会, 大阪, Domestic conferenceESD治療後の胃癌に対する腹腔鏡下胃切除症例の検討Poster presentation
- 第70回 手術手技研究会, May 2016, Japanese, 手術手技研究会事務局, 品川, Domestic conference腹腔鏡下直腸低位前方切除術における基本手技の積み重ねによる定型化への取り組みPublic symposium
- 第199回近畿外科学会, May 2016, Japanese, 近畿外科学会事務局, 大阪, Domestic conference第24回日本外科学会生涯教育セミナー 「胃癌」 病因論Public discourse
- 第37回癌免疫外科研究会, May 2016, Japanese, 癌免疫外科研究会, 川越, Domestic conference腫瘍に対する外科的切除の腫瘍誘導性骨髄由来抑制細胞(MDSC)に対する影響とその臨床的意義Public symposium
- 第37回癌免疫外科研究会, May 2016, Japanese, 癌免疫外科研究会, 川越, Domestic conference一般演題(口演)6 新規免疫療法Others
- 第199回近畿外科学会, May 2016, Japanese, 近畿外科学会事務局, 大阪, Domestic conferenceリンパ節転移の過程で神経内分泌分化を示した直腸癌の一例Oral presentation
- 第199回近畿外科学会, May 2016, Japanese, 近畿外科学会事務局, 大阪, Domestic conferenceイレウスを繰り返したNSAIDs起因性多発小腸潰瘍の1例Oral presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference大腸癌血行性転移切除後の再発に対する再切除の意義Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference側方リンパ節転移を伴う進行直腸癌に対する腹腔鏡下側方リンパ節郭清術についてPoster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference切除不能胃癌の集学的治療における外科手術介入の意義Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference新しい外科学の価値の創造(1) 化学療法と外科Others
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference食道扁平上皮癌における酸化ヌクレオチド浄化因子MTH1発現の生物学的意義と治療標的としての可能性Oral presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference食道癌根治切除術のリンパ節再発に対するSalvage CRTPoster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference左反回神経浸潤が疑われる#106recL転移リンパ節に対する胸腔鏡下神経温存郭清Oral presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference高齢者胃癌の術後合併症発生の危険因子の検討Oral presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference局所進行直腸癌に対する術前化学放射線療法の治療成績とその工夫Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conference胸腔鏡下食道切除術に対する3D内視鏡の導入Poster presentation
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conferenceランチョンセミナー 結腸癌に対する術後補助化学療法 現在、過去、未来Others
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conferenceディベート(4)幽門側胃切除の再建 -温故知新-Billroth-I法 vs Roux-en-Y法Others
- 第116回日本外科学会定期学術集会, Apr. 2016, Japanese, 一般社団法人日本外科学会, 大阪, Domestic conferenceNCDを基盤とした消化器外科領域の前向き研究への課題Others
- 第52回日本腹部救急医学会総会, Mar. 2016, Japanese, 日本腹部救急医学会, 東京, Domestic conference閉塞性大腸癌に対する大腸ステントによる術前減圧の有用性Oral presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conference当院におけるLECS症例の検討Poster presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conference食道胃接合部位癌の異時性肺転移切除により長期生存を得た1例Poster presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conference高齢者の胃癌切除後の予後規定因子の研究Poster presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conference完全内臓逆位に合併した胃癌に対し完全腹腔鏡下胃全摘を行った一例Poster presentation
- 第49回制癌剤適応研究会, Mar. 2016, Japanese, 制癌剤適応研究会, 会津若松, Domestic conference胃癌術後補助化学療法の展開2016[Invited]Invited oral presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conferenceリンパ節を細分化して行う安定した脾動脈近位側リンパ節(No.11p)郭清Poster presentation
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conferenceポスター 2-31 Predictive factor 7Others
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conferenceプレナリーセッション2 胃癌臨床試験:世界の試験総覧Others
- 第88回日本胃癌学会学術総会, Mar. 2016, Japanese, 一般社団法人 日本胃癌学会, 別府, Domestic conferenceStageIV胃癌の集学的治療における外科手術の意義Poster presentation
- 第12回日本消化管学会総会学術集会, Feb. 2016, Japanese, 日本消化管学会, 東京, Domestic conference大腸がん内視鏡切除後の追加外科切除例の検討Public symposium
- 第48回胃病態機能研究会, Feb. 2016, Japanese, 胃病態機能研究会, 東京, Domestic conference一般演題2 手術(2)Others
- 11th Annual Academic Surgical Congress, Feb. 2016, English, Society of University Surgeons, Association for Academic Surgery, Jacksonville, Florida, International conferenceComparison of two- and three-dimensional display for performance of laparoscopic total gastrectomyPublic symposium
- 第84回大腸癌研究会, Jan. 2016, Japanese, 大腸癌研究会, 熊本, Domestic conference治癒切除不能stageIV大腸癌に対する原発巣切除の意義Poster presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference慢性閉塞性肺疾患を合併した高齢者胃癌に対する腹腔鏡下胃切除術の安全性の検討Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡補助下・後縦隔経路再建術の手技と工夫Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference腹腔鏡下側方リンパ節郭清を安全に施行するために[Invited]Nominated symposium
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference腹臥位食道癌手術の利点と可能性[Invited]Nominated symposium
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference新しい3次元動作解析システムを用いた内視鏡手術の技術分析 - 3Dと2Dモニターにおける鉗子操作の比較検討 -Public symposium
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference左側閉塞性大腸癌に対しステント留置後に腹腔鏡下手術を施行した4例Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference胸腔鏡下食道切除術の治療成績の検討Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conference胃GISTに対する単孔式腹腔鏡下胃部分切除の手術成績と手技の工夫Oral presentation
- 第19回バイオ治療法研究会学術集会, Dec. 2015, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conferenceヒト大腸がん幹細胞のマイクロRNA発現に継代回数と移植部位がおよぼす影響Oral presentation
- 第28回日本内視鏡外科学会総会, Dec. 2015, Japanese, 一般社団法人 日本内視鏡外科学会, 大阪, Domestic conferenceパネルディスカッション22 腹腔鏡下幽門保存胃切除:究極の機能温存手術への飛躍Others
- 第19回バイオ治療法研究会学術集会, Dec. 2015, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conferenceiNKT細胞活性化療法における肝障害Oral presentation
- 第19回バイオ治療法研究会学術集会, Dec. 2015, Japanese, 特定非営利活動法人環瀬戸内自然免疫ネットワーク, 東京, Domestic conferenceDCG療法におけるCD40-CD40L interactionの抗腫瘍降下への影響Oral presentation
- 第26回日本消化器癌発生学会総会, Nov. 2015, Japanese, 日本消化器癌発生学会, 米子, Domestic conference大腸癌に対する術後補所化学療法Public discourse
- 第45回胃外科・術後障害研究会, Nov. 2015, Japanese, 胃外科・術後障害研究会, 名古屋, Domestic conference切除不能胃癌に対する外科切除例の予後規定因子に関する検討Oral presentation
- 第67回日本気管食道科学会総会ならびに学術講演会, Nov. 2015, Japanese, 日本気管食道科学会, 福島, Domestic conference食道癌術後胃管気管支瘻を来した1例Oral presentation
- 第26回日本消化器癌発生学会総会, Nov. 2015, Japanese, 日本消化器癌発生学会, 米子, Domestic conference腫瘍誘導性骨髄由来抑制細胞(MDSC)に対する早期治療は肺転移を抑制する[Invited]Nominated symposium
- 第26回日本消化器癌発生学会総会, Nov. 2015, Japanese, 日本消化器癌発生学会, 米子, Domestic conferenceアロ樹状細胞を用いた抗腫瘍免疫活性化の検討Poster presentation
- 第26回日本消化器癌発生学会総会, Nov. 2015, Japanese, 日本消化器癌発生学会, 米子, Domestic conferenceNCAMとFGFRの相互作用はヒト食道扁平上皮癌における腫瘍関連マクロファージの生存能および遊走能に関与するOral presentation
- 第26回日本消化器癌発生学会, Nov. 2015, Japanese, The Japanese Society for Gastroenterological Carcinogenesis, 米子, Domestic conferenceNCAMとFGFRの相互作用はヒト食道癌における腫瘍関連マクロファージの生存能および遊走能に関与するOral presentation
- 第45回胃外科・術後障害研究会, Nov. 2015, Japanese, 胃外科・術後障害研究会, 名古屋, Domestic conference3D内視鏡を用いた腹腔鏡下胃全摘術の有用性Oral presentation
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference優秀ビデオセッションOthers
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference腹臥位食道癌手術における左上縦隔郭清の工夫[Invited]Nominated symposium
- 第23回日本消化器関連学会週間(JDDW 2015), Oct. 2015, Japanese, JDDW 2015 運営委員会, 東京, Domestic conference早期胃癌に対するESD後非治癒症例のリンパ節転移とESD後腫瘍遺残の危険因子の検討Poster presentation
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conference食道扁平上皮癌におけるMTH1発現の意義の検討Public symposium
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference食道切除後の胸壁前経路有茎空腸再建術の有用性Public symposium
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference食道癌に対する腹腔鏡補助下胃管作成・後縦隔再建術Oral presentation
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference食道外科医からみた大動脈食道瘻の手術治療[Invited]Invited oral presentation
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conference教育シンポジウム5: 医工連携と癌治療Others
- 第68回日本胸部外科学会定期学術集会, Oct. 2015, Japanese, 特定非営利活動法人 日本胸部外科学会, 神戸, Domestic conference右鎖骨動脈起始異常を伴う食道癌に対する腹臥位胸腔鏡下食道切除術Oral presentation
- 第74回日本癌学会学術集会, Oct. 2015, Japanese, 日本癌学会, 名古屋, Domestic conferenceヒト大腸直腸がん幹細胞のマイクロRNA発現に異種移植部位がおよぼす影響Oral presentation
- 第74回日本癌学会学術総会, Oct. 2015, Japanese, 日本癌学会, 名古屋, Domestic conferenceヒト大腸癌のがん幹細胞のマイクロRNA発現に異種移植部位がおよぼす影響Poster presentation
- 第23回日本消化器関連学会週間(JDDW 2015), Oct. 2015, Japanese, JDDW 2015 運営委員会, 東京, Domestic conferenceデジタルポスターセッション 胃-免疫・内分泌、その他(研究)1Others
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conferenceTips of laparoscopic lateral lymph node dissection for rectal cancerOral presentation
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conferenceStageIII胃癌に対する術後補所化学療法DS vs S-1第III相試験(JACCRO GC-07)[Invited]Invited oral presentation
- 第23回日本消化器関連学会週間(JDDW 2015), Oct. 2015, Japanese, JDDW 2015 運営委員会, 東京, Domestic conferenceStage II, III大腸癌に対する腹腔鏡下手術の有効性Poster presentation
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conferenceFACO Surgery Session 3 "Esophagus"Others
- The 74th Annual Meeting of the Japanese Cancer Association, Oct. 2015, English, Japanese Cancer Association, 名古屋, Domestic conferenceEffect of the xenotransplantation site on the microRNA expression of human colorectal cancer stem cellsPoster presentation
- 第53回日本癌治療学会学術集会, Oct. 2015, Japanese, 一般社団法人 日本癌治療学会, 京都, Domestic conferenceCombined thoracoscopic esophagectomy and pedicled jejunal transfer for esophageal cancerOral presentation
- 第28回近畿内視鏡外科研究会, Sep. 2015, Japanese, 近畿内視鏡外科研究会事務局, 和歌山, Domestic conference腹臥位食道癌手術におけるエネルギーデバイスの使い分けとコツPublic symposium
- 第28回近畿内視鏡外科研究会, Sep. 2015, Japanese, 近畿内視鏡外科研究会事務局, 和歌山, Domestic conference当教室における内視鏡外科技術認定(大腸)取得を目指す取り組み(弟子の立場から)Oral presentation
- 第28回近畿内視鏡外科研究会, Sep. 2015, Japanese, 近畿内視鏡外科研究会事務局, 和歌山, Domestic conference胃GISTに対する単孔式腹腔鏡下胃部分切除術の手術成績と手技の工夫Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference腹腔鏡下直腸切除術においていかに縫合不全を減らすか - 当科での工夫 -Oral presentation
- 第25回日本サイトメトリー学会学術集会, Jul. 2015, Japanese, 日本サイトメトリー学会, 東京, Domestic conference特定因子の導入による人工大腸癌幹細胞の誘導Oral presentation
- 第83回大腸癌研究会, Jul. 2015, Japanese, 大腸癌研究会, 久留米, Domestic conference大腸癌肝転移切除後の再発巣に対する切除の意義Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference大腸癌イレウスに対する術前減圧後の腹腔鏡下切除術の有用性Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference食道切除術施行患者における経腸栄養の有用性Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference食道切除後の胸壁前経路有茎空腸再建術の有用性Oral presentation
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference食道癌手術における静脈血栓塞栓症予防 - エノキサパリンの安全性とVTEリスク因子の検討 -Poster presentation
- 第37回日本癌局所療法研究会, Jul. 2015, Japanese, 日本癌局所療法研究会, 千葉, Domestic conference食道癌根治切除後の局所再発に対するSalvage CRTに関する検討Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference重複癌を有する食道切除術の意義Oral presentation
- 第25回日本サイトメトリー学会学術集会, Jul. 2015, Japanese, 日本サイトメトリー学会, 東京, Domestic conference腫瘍誘導性骨髄由来抑制細胞(MDSC)に対する早期治療は肺の転移を抑制するOral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference手術合併症危険因子からみた残胃癌外科治療の検討Oral presentation
- 第37回日本癌局所療法研究会, Jul. 2015, Japanese, 日本癌局所療法研究会, 千葉, Domestic conference主題III-4 遠隔転移を伴う症例に対する局所療法の意義Others
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference再建臓器血流を勘考した再建・吻合方法の選択と成績Poster presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference合併症低減に向けた胸部食道癌手術Oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference高齢者食道癌における術前補助化学療法についてOral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference高齢者胃癌に対する胃切除術の予後規定因子の検討Oral presentation
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference嫌気性菌感染により広範な食道壁内解離をきたした下部食道癌の1例Poster presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference局所進行癌に対する術前化学放射線療法を中心とした集学的治療Oral presentation
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference胸腔鏡下食道切除術の低侵襲性と根治性の両立を目指してPoster presentation
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference一般演題 ポスター50 「術前化学療法2」Others
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conference一般演題 ポスター20 「合併症(狭窄・腸閉塞)」Others
- 第25回日本サイトメトリー学会学術集会, Jul. 2015, Japanese, 日本サイトメトリー学会, 東京, Domestic conference一般演題1「サイトカイン・免疫(1)」Others
- 第37回日本癌局所療法研究会, Jul. 2015, Japanese, 日本癌局所療法研究会, 千葉, Domestic conferenceクローン病長期寛解後に同時性二重大腸癌を発症した一例Oral presentation
- 第24回日本がん転移学会学術集会・総会, Jul. 2015, Japanese, 日本がん転移学会事務局, 大阪, Domestic conferenceNKT細胞活性化の抗腫瘍効果におけるアロ樹状細胞の有用性Poster presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conferenceNCDデータを活用した腹腔鏡下胃切除術に関する臨床試験の展開[Invited]Invited oral presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conferenceInternational Video Symposium3 [English] : ColorectumOthers
- 第69回日本食道学会学術集会, Jul. 2015, Japanese, 特定非営利活動法人 日本食道学会, 横浜, Domestic conferenceALBとCRP値を用いた術前補助化学療法の効果と術後合併症の予測Poster presentation
- 第70回日本消化器外科学会, Jul. 2015, Japanese, 一般社団法人 日本消化器外科学会, 浜松, Domestic conference80歳以上の超高齢者大腸癌患者に対する腹腔鏡下手術の有用性についてOral presentation
- 第9回単孔式内視鏡手術研究会, Jul. 2015, Japanese, 単孔式内視鏡手術研究会事務局, 秋田, Domestic conference3D内視鏡下での単孔式腹腔鏡下横行結腸切除術について[Invited]Invited oral presentation
- 第40回日本外科系連合学会学術集会, Jun. 2015, Japanese, 日本外科系連合学会, 東京, Domestic conference当院における食道癌患者に対するNEST介入についてPublic symposium
- 第58回関西胸部外科学会学術集会, Jun. 2015, Japanese, 関西胸部外科学会事務局, 岡山, Domestic conference招請講演4 食道癌に対する胸腔鏡下食道切除術の現状と展望Others
- 第40回日本外科系連合学会学術集会, Jun. 2015, Japanese, 日本外科系連合学会, 東京, Domestic conference高齢者胃癌に対する異説叙述後合併症の予後に及ぼす影響Public symposium
- 第40回日本外科系連合学会学術集会, Jun. 2015, Japanese, 日本外科系連合学会, 東京, Domestic conference形成外科との連携による微小血管吻合を用いた食道再建術の現状Public symposium
- 第24回日本癌病態治療研究会, Jun. 2015, Japanese, NPO法人 日本癌病態治療研究会事務局, 日光, Domestic conferenceワークショップ2 バイオマーカーと遺伝子Others
- 第40回日本外科系連合学会学術集会, Jun. 2015, Japanese, 日本外科系連合学会, 東京, Domestic conferenceシンポジウム1 高齢者手術の周術期管理の工夫 -各領域のメディカルスタッフの立場からOthers
- 23rd International congress of the European Association for Endoscopic Surgery (EAES), Jun. 2015, English, The European Association for Endoscopic Surgery, Bucharest, International conferenceOutcome of Laparoscopic Colorectal Resection for Cancer in Elderly People at least 85 Years OldOral presentation
- 23rd International congress of the European Association for Endoscopic Surgery (EAES), Jun. 2015, English, The European Association for Endoscopic Surgery, Bucharest, International conferenceLaparoscopic Surgery for the Patients with Gastric Cancer and Situs Inversus TotalisPoster presentation
- 23rd International congress of the European Association for Endoscopic Surgery (EAES), Jun. 2015, English, The European Association for Endoscopic Surgery, Bucharest, International conferenceLaparoscopic Ileocecal Resection Can Be Applied for Appendiceal Cancer with a Fistula to the Ileum.Poster presentation
- 23rd International congress of the European Association for Endoscopic Surgery (EAES), Jun. 2015, English, The European Association for Endoscopic Surgery, Bucharest, International conferenceA Comparison of Laparoscopic Surgery and Open Surgery for Advanced Rectal CancerPoster presentation
- 第40回日本外科系連合学会学術集会, Jun. 2015, Japanese, 日本外科系連合学会, 東京, Domestic conference85歳以上の超高齢者大腸癌患者に対する腹腔鏡手術の有用性の検討Public symposium
- 第24回日本癌病態治療研究会, Jun. 2015, Japanese, NPO法人 日本癌病態治療研究会事務局, 日光, Domestic conference3D映像が内視鏡外科手術にもたらす効果の検討Public symposium
- 第69回手術手技研究会, May 2015, Japanese, 手術手技研究会事務局, 高崎, Domestic conference腹腔鏡下直腸切除術における簡便な綿テープ牽引法を用いた術野展開の工夫について[Invited]Nominated symposium
- 第69回手術手技研究会, May 2015, Japanese, 手術手技研究会事務局, 高崎, Domestic conference直腸癌に対する腹開陰式直腸切断術における骨盤大網形成術による感染対策Keynote oral presentation
- 第197回近畿外科学会, May 2015, Japanese, 近畿外科学会事務局, 大阪, Domestic conference大腸(1)Others
- 第69回手術手技研究会, May 2015, Japanese, 手術手技研究会事務局, 高崎, Domestic conference臓器血流に配慮した食道再建術の工夫Public symposium
- 第69回手術手技研究会, May 2015, Japanese, 手術手技研究会事務局, 高崎, Domestic conference食道癌手術における3D-CTによる気管支動脈走行の術前ナビゲーションPublic symposium
- 第36回癌免疫外科研究会, May 2015, Japanese, 癌免疫外科研究会, 奄美, Domestic conference腫瘍誘導性骨髄由来抑制細胞(MDSC)に対する治療は肺の転移を抑制するOral presentation
- 第36回癌免疫外科研究会, May 2015, Japanese, 癌免疫外科研究会, 奄美, Domestic conference一般口演5「マーカー」Others
- 第36回癌免疫外科研究会, May 2015, Japanese, 癌免疫外科研究会, 奄美, Domestic conferenceαGalCer-NKT細胞活性化の抗腫瘍効果におけるアロ樹状細胞の有用性Oral presentation
- 第36回癌免疫外科研究会, May 2015, Japanese, 癌免疫外科研究会, 奄美, Domestic conferenceヒト乳がん手術検体異種移植腫瘍の増殖抑制に関わるNK細胞浸潤機構の検討Oral presentation
- 2015 ASCO Annual Meeting, May 2015, English, American Society of Clinical Oncology, Chicago, Illinois, International conferenceReGISTry Study of High Risk GIST Patients After Complete Resection:The adjuvant therapy and pathological diagnosis in Japan.Poster presentation
- 2015 ASCO Annual Meeting, May 2015, English, American Society of Clinical Oncology, Chicago, Illinois, International conferencePre-planned feasibility and safety analyses of docetaxel/S-1 combination in a phase III study comparing docetaxel/S-1with S-1 alone as postoperative adjuvant chemotherapy for stage III gastric cancer (JACCRO GC-07).Others
- 2015 ASCO Annual Meeting, May 2015, English, American Society of Clinical Oncology, Chicago, Illinois, International conferenceA central review of liver resectability and pathological tumor response after chemotherapy in patients with initially unresectable colorectal cancer liver metastases: Phase II trials of mFOLFOX6 plus bevacizumab (KSCC0802), and SOX (S-1 and oxaliplatin) pOthers
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference反回神経麻痺の低減を目指した胸腔鏡下食道切術の定型化と工夫Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 日本外科学会, 名古屋, Domestic conference当施設における女性外科医のリクルートと支援[Invited]Invited oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference直腸癌に対する腹腔鏡下手術の有用性についてOral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference大腸癌治療戦略最前線Public discourse
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference大腸癌の両葉多発肝転移に対する術前化学療法の安全性と有用性Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference食道切除後の胸壁前経路有茎空腸再建術の有用性Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference食道癌手術におけるエノキサパリンの安全性及び投与下におけるVTE リスク因子の検討Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference治癒切除不能大腸癌に対する原発巣切除の意義Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference高齢者胃癌に対する安全な術式選択Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference化学放射線療法後の進行直腸癌に対する腹腔鏡下手術の有用性の検討Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conferenceSiewert II 型食道胃接合部癌に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と簡便な偽His角・fornix 形成食道胃管吻合法Oral presentation
- 第115回日本外科学会定期学術集会, Apr. 2015, Japanese, 一般社団法人日本外科学会, 名古屋, Domestic conference75 歳以上高齢者食道癌に対する術前化学療法と手術の安全性Oral presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference噴門側胃切除後の残胃癌についてPoster presentation
- 第2回神戸外科手術・感染症セミナー, Mar. 2015, Japanese, 大正富山医薬品株式会社, 神戸, Domestic conference特別講演2[Invited]Invited oral presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference短期予後からみた高齢者胃癌に対する外科治療の検討Public symposium
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference神経内分泌細胞成分を伴う胃癌に対する集学的治療の有用性Poster presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference食道胃接合部腺癌におけるリンパ節転移分布および再発形式からみた縦隔リンパ節郭清範囲の検討Public discourse
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference高度進行胃癌に対するconversion surgeryの意義と時期についてPoster presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference教室における胃肝癌症例の検討Poster presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference遠位側胃切除後に発生した残胃癌に対する手術成績の検討Poster presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conference胃GISTに対する腹腔鏡下胃切除の有用性Poster presentation
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conferenceパネルディスカッション7 高齢者に対する術後補所化学療法の問題点と工夫[Invited]Nominated symposium
- 第87回日本胃癌学会総会, Mar. 2015, Japanese, 日本胃癌学会, 広島, Domestic conferenceESD治療後の胃癌に対する腹腔鏡下胃切除症例の検討Poster presentation
- 日本消化器病学会近畿支部 第102回例会, Feb. 2015, Japanese, 日本消化器病学会, 京都, Domestic conference当院における食道癌根治切除後の局所再発に対するSalvage CRTに関する検討Oral presentation
- 神戸大学外科創傷セミナー(SSIに対する新たなる挑戦), Jan. 2015, Japanese, KCI, 神戸, Domestic conference症例報告ディスカッション[Invited]Invited oral presentation
- 神戸大学外科創傷セミナー(SSIに対する新たなる挑戦), Jan. 2015, Japanese, KCI, 神戸, Domestic conference教育講演Oral presentation
- 第4回神戸Robotic Surgeryセミナー, Dec. 2014, Japanese, コヴィディエンジャパン, 神戸, Domestic conference特別講演 ロボット支援胃切除術の導入経験と今後の展望Public discourse
- Chugai Colorectal Cancer Symposium in HYOGO, Nov. 2014, Japanese, 中外製薬株式会社, 神戸, Domestic conference特別講演II 大腸癌肝転移に対する化学療法の意義と効果判定の新しい考え方Public discourse
- 第25回日本消化器癌発生学会総会, Nov. 2014, Japanese, 日本消化器癌発生学会, 福岡, Domestic conference転移性肺腫瘍に対する治療標的としての腫瘍誘導性骨髄由来抑制細胞Oral presentation
- 第69回日本大腸肛門病学会学術集会, Nov. 2014, Japanese, 日本大腸肛門病学会, 横浜, Domestic conference大腸癌 基礎Public discourse
- 第25回日本消化器癌発生学会総会, Nov. 2014, Japanese, 日本消化器癌発生学会, 福岡, Domestic conference腫瘍関連マクロファージが分泌するGDF15は食道扁平上皮癌の腫瘍増殖、進展に関与するOral presentation
- 第66回日本気管食道科学会, Nov. 2014, Japanese, 日本気管食道科学会, 高知, Domestic conference気道狭窄をきたした食道神経鞘腫の1例Oral presentation
- 第25回日本消化器癌発生学会総会, Nov. 2014, Japanese, 日本消化器癌発生学会, 福岡, Domestic conferenceポスター14 症例報告(2)[Invited]Invited oral presentation
- 第2回北大阪大腸癌化学療法カンファレンス, Nov. 2014, Japanese, Bristol-Myers Squibb、Merck Serono, 大阪, Domestic conferenceセツキシマブの特徴を活かした大腸癌治療戦略Public discourse
- 第76回日本臨床外科学会総会, Nov. 2014, Japanese, 日本臨床外科学会, 郡山, Domestic conferenceStage IV胃癌に対する外科治療[Invited]Invited oral presentation
- 第25回日本消化器癌発生学会総会, Nov. 2014, Japanese, 日本消化器癌発生学会, 福岡, Domestic conferenceAllogeneoc DCGを用いたNKT細胞活性化と抗腫瘍効果の検討Oral presentation
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference要望演題(ビデオ)1 研修医・専門医によるビデオ(吻合・縫合)1[Invited]Invited oral presentation
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference腹腔鏡下大腸全摘出術における小切開を置かない回腸嚢作成方法についてOral presentation
- 神戸消化器外科カンファレンス, Oct. 2014, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference特別講演I 腹腔鏡でみる進行直腸癌手術に役立つ骨盤解剖Public discourse
- 第12回神戸消化器外科懇話会学術講演会, Oct. 2014, Japanese, 神戸消化器外科懇話会、株式会社大塚製薬工場、イーエヌ大塚製薬株式会社, 神戸, Domestic conference特別講演I 食道癌集学的治療における個別化とsalvage surgeryPublic discourse
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference当院における高齢者大腸癌腹腔鏡手術成績Oral presentation
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference食道癌に対する胸腔鏡下手術の長期成績Oral presentation
- JDDW 2014 (Japan Digestive Disease Week 2014)第22回日本消化器関連学会週間, Oct. 2014, Japanese, JDDW, 神戸, Domestic conference根治切除不能なStage4大腸癌に対して、原発巣切除を先行する意義Poster presentation
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference高齢者胃癌に対する腹腔鏡補助下幽門側胃切除の安全性の検討Oral presentation
- JDDW 2014 (Japan Digestive Disease Week 2014)第22回日本消化器関連学会週間, Oct. 2014, Japanese, JDDW, 神戸, Domestic conferenceランチョンセミナー53 集学的治療としての鏡視下手術の役割Public discourse
- JDDW 2014 (Japan Digestive Disease Week 2014)第22回日本消化器関連学会週間, Oct. 2014, Japanese, JDDW, 神戸, Domestic conferenceデジタルポスターセッション 胃6[Invited]Nominated symposium
- 第27回内視鏡外科学会総会, Oct. 2014, Japanese, 内視鏡外科学会, 盛岡, Domestic conference3Dハイビジョン映像システムによって腹腔鏡下大腸切除術はどう変わるかOral presentation
- 第6回日本Acute Care Surgery学会学術集会, Sep. 2014, Japanese, 日本Acute Care Surgery 学会学術, 青森, Domestic conference閉塞性大腸癌に対する術前減圧後の腹腔鏡下切除術の有用性Oral presentation
- 第27回近畿内視鏡外科研究会, Sep. 2014, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference噴門GISTに対する腹腔鏡下局所切除における手技の工夫と治療成績Oral presentation
- 第10回神戸がん研究会, Sep. 2014, Japanese, 神戸がん研究会, 神戸, Domestic conference特別講演II 消化器がん克服を目指した探索的医療開発Public discourse
- The 73rd Annual Meeting of the Japanese Cancer Association, Sep. 2014, Japanese, Japanese Cancer Association, 横浜, Domestic conferenceClinicopathological significance of GDF15 in the microenvironment of human esophageal squamous cell carcinomaPoster presentation
- 第6回日本Acute Care Surgery学会学術集会, Sep. 2014, Japanese, 日本Acute Care Surgery 学会学術, 青森, Domestic conference呼吸困難にて発症した食道脂肪肉腫の1例Oral presentation
- 第27回近畿内視鏡外科研究会, Sep. 2014, Japanese, 近畿内視鏡外科研究会, 神戸, Domestic conference右鎖骨下動脈起始異常を伴う食道癌に対する腹臥位腔鏡下食道切除術の経験Oral presentation
- The 73rd Annual Meeting of the Japanese Cancer Association, Sep. 2014, Japanese, Japanese Cancer Association, 横浜, Domestic conferenceEffect of natural killer cell infiltration on the growth of the mouse xenografts tumors of human breast cancers.Poster presentation
- The 73rd Annual Meeting of the Japanese Cancer Association, Sep. 2014, English, Japanese Cancer Association, 横浜, Domestic conferenceEffect of natural killer cell infiltration on the growth of the mouse xenografts tumors of human breast cancers.Poster presentation
- CRC Core Meeting in KOBE, Sep. 2014, Japanese, Bristol-Myers Squibb、Merck Serono, 神戸, Domestic conferenceASCO、ESMOGI後の大腸癌治療を考えるPublic discourse
- 3rd Reduced Port Surgery Forum 2014 in Fukui, Aug. 2014, Japanese, 単孔式内視鏡手術研究会, 福井, Domestic conference縫合不全に対し単孔式腹腔鏡下回瘻増設術を施行した3例Oral presentation
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 横浜, Domestic conference食道癌に対する手術治療の最前線[Invited]Nominated symposium
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 横浜, Domestic conference食道がん[Invited]Nominated symposium
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 横浜, Domestic conference高齢者大腸癌に対する腹腔胸手術の有用性についてPoster presentation
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 横浜, Domestic conference胃癌における機能温存手術Oral presentation
- 第52回日本癌治療学会学術集会, Aug. 2014, Japanese, 日本癌治療学会, 横浜, Domestic conferenceシンポジウム04 胃がん治療戦略のUp to Date[Invited]Nominated symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference有茎空腸再建術における手技の工夫-良好な血流と挙上性を確保するコツ-Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference腹腔鏡下側方リンパ節郭清のコツ~2つの膜を意識して~Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference腹腔鏡下胃癌手術における合併症危険因子と治療成績向上にむけた対策Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器病学会, 福島, Domestic conference大腸癌肝転移術前化学療法における新しい組織学的効果判定基準mTRGの有用性Keynote oral presentation
- 第23回がん転移学会学術集会・総会, Jul. 2014, Japanese, がん転移学会, 金沢, Domestic conference大腸癌肝転移に対する治療の現況Public symposium
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference食道癌術後合併症対策-当科における取り組みOral presentation
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference食道癌術後胃管気管瘻に対し、大胸筋皮弁を用いた修復術を行った1例Poster presentation
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference食道Liposarcomaの1例Poster presentation
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference術前補助化学療法を施行した食道癌cStageII/IIIにおけるmGPSの意義Poster presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference術前化学放射線療法を用いた側方リンパ節転移陽性進行直腸癌の治療成績Oral presentation
- 第23回がん転移学会学術集会・総会, Jul. 2014, Japanese, がん転移学会, 金沢, Domestic conference骨髄由来抑制細胞(MDSC)の癌転移に対する治療的意義Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference高齢者大腸癌症例の手術適応Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference高齢者食道癌に対する術前化学療法+鏡視下手術は標準治療となりうるOral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conference高齢者胃癌に対する腹腔鏡補助下幽門側胃切除の安全性の検討Oral presentation
- 新時代の切除不能進行・再発大腸癌治療を考える, Jul. 2014, Japanese, 武田薬品工業株式会社, 姫路, Domestic conference抗EGFR抗体を用いた治療戦略ASC最新報告活かす最新治療戦略2014Public discourse
- 大腸がん治療を高めるためにIN HIROSAKI, Jul. 2014, Japanese, 武田薬品工業株式会社, 弘前, Domestic conference抗EGFR抗体を用いた治療戦略ASC最新報告Public discourse
- 大腸癌 Meeting~生存期間の延長を目指して~, Jul. 2014, Japanese, 武田薬品工業株式会社, 加古川, Domestic conference抗EGFR抗体を活かす最新治療戦略2014Public discourse
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference胸部食道癌に対する胸腔鏡下食道切除術の遠隔治療成績の検討Oral presentation
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference気道狭窄を呈した食道神経鞘腫の一例Poster presentation
- 第68回日本食道学会学術集会, Jul. 2014, Japanese, 日本食道学会, 東京, Domestic conference一般演題 癌 ポスター61 予測因子3Oral presentation
- 第69回日本消化器外科学会総会, Jul. 2014, Japanese, 日本消化器外科学会, 郡山, Domestic conferenceランチョンセミナー OS延長を目指す新時代の抗EGFR抗体薬の使い方Public discourse
- 平成大腸癌カンファレンス, Jul. 2014, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceSessionII 静岡がんセンターでの直腸癌手術への取り組み[Invited]Nominated symposium
- 兵庫県消化器外科研究会2014, Jul. 2014, Japanese, 小野薬品工業株式会社, 青森, Domestic conferenceSessionII消化器がんの臨床と研究 up to datePublic discourse
- Chugai Colorectal Cancer Symposium in HYOGO, Jul. 2014, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceSession 2 パネルディスカッション[Invited]Nominated symposium
- 水利尿カンファレンス, Jun. 2014, Japanese, 大塚製薬, 神戸, Domestic conference特別講演I 非代償性肝硬変患者の浮腫・腹水における新しい治療戦略~バソプレシンV2受容体拮抗剤~Public discourse
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 日本癌局所療法研究会, 八尾, Domestic conference術前化学放射線療法により直腸切除術を施行した進行痔瘻癌の一例Oral presentation
- 第23回近畿過大侵襲研究会, Jun. 2014, Japanese, -, 大阪, Domestic conference胸部食道癌術後に胃管気管瘻を生じ、大胸筋皮弁による修復術を行った1例Oral presentation
- 第57回関西胸部外科学会, Jun. 2014, Japanese, -, 大阪, Domestic conference胸腔鏡手術は術直後の酸素化能が保たれており、開胸手術と同等の根治性を有するOral presentation
- Chugai Colorectal Cancer Seminar, Jun. 2014, Japanese, 中外製薬株式会社, 神戸, Domestic conference何を、どう使う?分子標的薬の治療戦略2014[Invited]Invited oral presentation
- 第36回日本癌局所療法研究会, Jun. 2014, Japanese, 日本癌局所療法研究会, 八尾, Domestic conference胃10[Invited]Nominated symposium
- 第39回日本外科系連合学会学術集会, Jun. 2014, Japanese, -, 東京, Domestic conferenceシンポジウム4 胸部領域の鏡視下手術 -手術の工夫と安全対策 -[Invited]Nominated symposium
- 第23回日本癌病態治療研究会, Jun. 2014, Japanese, 日本癌病態研究会, 岐阜, Domestic conferenceアロ樹状細胞を用いたNKT細胞活性化と抗腫瘍効果の検討Oral presentation
- 第24回日本サイトメトリー学会学術集会, Jun. 2014, Japanese, 日本サイトメトリー学会, 枚方, Domestic conferenceアロ樹状細胞を用いたCTL誘導の試み[Invited]Nominated symposium
- The 60th Annual Congress of International College of Surgeons Japan Section, Jun. 2014, English, Department of General Surgical science, 高崎, International conferenceExperience of totally laparoscopic partial resection for hemangioma in the third portion of the duodenumOral presentation
- 第57回関西胸部外科学会, Jun. 2014, Japanese, -, 大阪, Domestic conferenceCase Presentation Awards: 食道疾患[Invited]Invited oral presentation
- 第25回日本在宅医療学会学術集会, May 2014, Japanese, 日本在宅医療学会, 倉敷, Domestic conference分子標的薬を使いこなす(1) 胃癌・大腸癌[Invited]Invited oral presentation
- 第68回手術手技研究会, May 2014, Japanese, 日本大学医学部消化器外科, 東京, Domestic conference腹腔鏡下直腸低位前方切除術における術野展開の工夫についてOral presentation
- 第68回手術手技研究会, May 2014, Japanese, 日本大学医学部消化器外科, 東京, Domestic conference腹腔鏡下胃癌手術における層構造を意識した脾動脈近位側リンパ説郭清Oral presentation
- 第35回癌免疫外科研究会, May 2014, Japanese, -, 大阪, Domestic conference肺転移における骨髄由来抑制細胞の影響と治療的意義Oral presentation
- 第2回外科感染症セミナーin Kobe, May 2014, Japanese, 旭化成ファーマ株式会社、ファイザー株式会社, 神戸, Domestic conference敗血症性DICに対する治療戦略~抗凝固療法の現状と今後の展望~Public discourse
- 第46回兵庫県手術手技研究会, May 2014, Japanese, 持田製薬株式会社, 神戸, Domestic conference特別講演 食道胃接合部癌に対する治療戦略Oral presentation
- 嶺南化学療法研究会, May 2014, Japanese, 武田薬品工業株式会社, 敦賀, Domestic conference抗EGFR抗体の意義-RAS解析に基づくOS延長を見据えた大腸癌治療戦略-[Invited]Invited oral presentation
- V.A.C Summit関西, May 2014, Japanese, KCI, 神戸, Domestic conference教育講演(総論) 消化器外科領域におけるSSIの現状とその対策Public discourse
- 第35回癌免疫外科研究会, May 2014, Japanese, -, 大阪, Domestic conference一般演題(口演)7「micro-RNA・予後因子」Oral presentation
- 第195回近畿外科学会, May 2014, Japanese, 近畿外科学会, 天王寺, Domestic conferenceESDを契機に発症したと考えられる急性虫垂炎の一例Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference腹臥位食道切除術による術後酸素化能維持と肺合併症減少Poster presentation
- 第3回神戸Robotic Surgeryセミナー, Apr. 2014, Japanese, コヴィディエンジャパン, 神戸, Domestic conference特別講演Public discourse
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference当院における大腸癌肺転移切除症例の検討Poster presentation
- The 87th congress of the Japan gastroenterological endoscopy society, Apr. 2014, Japanese, the Japan gastroenterological endoscopy society, 福岡, Domestic conferenceOutcome of endoscopic therapy in superficial Barrett's esophageal carcinomaPoster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference直腸癌側方リンパ節転移症例に対する術前化学放射線療法による治療効果Oral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference大腸癌肝転移切除後の再発巣に対する再切除の意義Poster presentation
- 第103回日本病理学会総会, Apr. 2014, Japanese, 日本病理学会, 広島, Domestic conference食道扁平上皮癌に浸潤する腫瘍組織内CD204陽性マクロファージは腫瘍増殖、進展に関与するPoster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference食道切除術施行患者における経腸栄養の有用性Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference術前化学放射線療法を施行した下部直腸癌に対する腹腔鏡下手術の有用性Oral presentation
- 第103回日本病理学会総会, Apr. 2014, Japanese, 日本病理学会総会, 広島, Domestic conference腫瘍関連マクロファージで高発現する接着分子や細胞外基質の機能解析Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference高齢者食道癌に対する術前補助化学療法の検討Poster presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conference胃癌肝転移に対する化学療法および手術療法の成績からみた治療戦略Poster presentation
- 大腸がんと言われた時~専門医による治療の最前線~, Apr. 2014, Japanese, 神戸新聞社, 神戸, Domestic conferenceみんなで取り組む大腸がん治療Public discourse
- 大腸癌治療ガイドライン講座-ガイドライン改定特別番組-, Apr. 2014, Japanese, 中外製薬株式会社, 神戸, Domestic conferenceSession5 神戸サイト企画: Q&APublic discourse
- 第114回日本外科学会定期学術集会, Apr. 2014, Japanese, 一般社団法人日本外科学会, 京都, Domestic conferenceLinear Stapler再建による完全鏡視下幽門側胃切除から胃全摘への安全確実なStep upOral presentation
- 第114回日本外科学会定期学術集会, Apr. 2014, English, 一般社団法人日本外科学会, 京都, Domestic conferenceInternational Session (10) Upper gastrointestinal tract surgery[Invited]Nominated symposium
- スチバーガ承認1周年記念講演会, Mar. 2014, Japanese, バイエル薬品株式会社, 神戸, Domestic conference特別講演 外来治療におけスチバーガの使い方~愛知県がんセンター中央病院での取り組み~Public discourse
- Colorectal Cancer Experts Meeting, Mar. 2014, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference特別講演 S-1:5-FU最終兵器Public discourse
- 神戸外科手術・感染症セミナー, Mar. 2014, Japanese, 大正富山医薬品株式会社, 神戸, Domestic conference特別講演1 敗血症性ショックの病態と治療~2014MEIDAIバンドルM13S6~Public discourse
- The 86th Annual Meeting of Japanese Gastric Association, Mar. 2014, Japanese, Meeting of Japanese Gastric Association, 横浜, Domestic conference当科における胃神経内分泌細胞癌8例の検討Oral presentation
- The 47th Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, Mar. 2014, Japanese, Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, 名古屋, Domestic conference大腸癌肝転移conversion例の検討、新しい組織学的効果判定基準、modified Tumor Regression Grade (mTRG)の再発予測における有用性Oral presentation
- 第50回日本腹部救急医学会総会, Mar. 2014, Japanese, 日本腹部救急医学会, 新宿, Domestic conference主題関連演題2 上部消化官術後合併症の診断と治療Public discourse
- The 47th Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, Mar. 2014, Japanese, Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, 名古屋, Domestic conference高齢者食道癌に対するNAC+手術治療の現状と課題Oral presentation
- The 47th Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, Mar. 2014, Japanese, Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, 名古屋, Domestic conference継続と展開 胃癌集学的治療戦略2014Oral presentation
- The 50th Annual Congress of Japanese Society for Abdominal Emergency Medicine, Mar. 2014, Japanese, Japanese Society for Abdominal Emergency Medicine, 東京, Domestic conference経鼻、経肛門的チューブ減圧後に切除された閉寒性大腸癌症例の検討Oral presentation
- 神戸外科手術・感染症セミナー, Mar. 2014, Japanese, 大正富山医薬品株式会社, 神戸, Domestic conference開会の辞Public discourse
- The 86th Annual Meeting of Japanese Gastric Association, Mar. 2014, Japanese, Meeting of Japanese Gastric Association, 横浜, Domestic conference胃癌肝転移に対する治療戦略-肝切除の意義と役割-Oral presentation
- The 86th Annual Meeting of Japanese Gastric Association, Mar. 2014, Japanese, Meeting of Japanese Gastric Association, 横浜, Domestic conference胃GISTに対する腹腔鏡下胃局所切除の有用性Oral presentation
- 大腸癌治療セミナー in Kobe, Feb. 2014, Japanese, 大鵬薬品工業株式会社, 神戸, Domestic conference特別講演 直腸癌治療の最前線 ~ロボット手術を含めて~Public discourse
- 第16回神戸外科フォーラム, Feb. 2014, Japanese, 神戸外科フォーラム、 大薬品工業株式会社, 神戸, Domestic conference特別講演I 胃癌化学療法のトピックス:術後補助化学療法の二次治療Public discourse
- The 6th Annual Congress of Japan Robotic Surgery Society, Feb. 2014, Japanese, JAPAN ROBOTIC SURGERY SOCIETY, 福岡, Domestic conference当科におけるロボット支援腹腔鏡下直腸低位前方切除術の導入についてOral presentation
- 9th Annual Academic Surgical Congress, Feb. 2014, English, Academic Surgical Congress, San Diego, The United States, International conferenceModified Glasgow Prognostic Score Predicts Histological Respose of Neoadjuvant Chemotherapy in cStage II or III Esoph-ageal Cancer[Invited]Oral presentation
- 9th Annual Academic Surgical Congress, Feb. 2014, English, Academic Surgical Congress, サンディエゴ, USA, International conferenceModified Glasgow Prognostic Score Predicts Histological Response of Neoadjuvant Chemotherapy in cStage II or III Esophageal CancerOral presentation
- 9th Annual Academic Surgical Congress, Feb. 2014, English, Academic Surgical Congress, サンディエゴ, USA, International conferenceCurrent State and Results of Treatment for Liver Metastases from Colorectal CancerOral presentation
- The 80th Meeting of Japanese Society for Cancer of the Colon and Rectum, Jan. 2014, Japanese, 東京, Domestic conference進行下部直腸癌治療における腹腔鏡下手術の意義Oral presentation
- mCRC Expert Meeting in Yokkaichi 2014, Jan. 2014, Japanese, Takeda Pharmaceutical Company Limited, YOKKAICHI MEDICAL ASSOCIATION, 四日市, Domestic conference新たなステージを迎えた大腸がん治療戦略-抗EGFR抗体の意義を考える-Public discourse
- The 4th JCA-AACR Special Joint Conference:The Latest Advances in Gastric Cancer Research:, Dec. 2013, English, JCA-AACR, Urayasu, gastric cancer, fibroblast, International conferenceDirect cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cellsPoster presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference閉寒性大腸癌に対する経肛門イレウスチューブ減圧後の腹腔鏡下手術例の検討Oral presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference腹腔鏡下手術における簡便なセプラフィルム貼付法Oral presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference腹臥位鏡視下食道切除における術後酸素化能の改善Oral presentation
- The 75th Annual Congress of Japan Surgical Association, Nov. 2013, Japanese, Annual Congress of Japan Surgical Association, 名古屋, Domestic conference特別講演 8、静脈血栓寒栓症Oral presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference当科におけるロボット支援腹腔鏡下直腸低位前方切除術について[Invited]Invited oral presentation
- 第15回近畿内視鏡下大腸手術研究会, Nov. 2013, Japanese, 近畿内視鏡下大腸手術研究会, 大阪, Domestic conference大腸癌に対する集学的治療戦略~いかに手術に持っていくか?~Keynote oral presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference食道胃接合部に近接する胃粘膜下腫瘍に対する腹腔鏡下胃部分切除の手術成績と手技の工夫Oral presentation
- The 75th Annual Congress of Japan Surgical Association, Nov. 2013, Japanese, Annual Congress of Japan Surgical Association, 名古屋, Domestic conference上気道・上部消化管5重複癌の一例[Invited]Invited oral presentation
- THE 26TH ANNUAL MEETING OF THE JAPAN SOCIETY FOR ENDPSCOPIC SURGERY, Nov. 2013, Japanese, JAPAN SOCIETY FOR ENDOSCOPIC SURGERY, 福岡, Domestic conference残胃癌に対する腹腔鏡補助下残胃全摘術の検討Oral presentation
- The 75th Annual Congress of Japan Surgical Association, Nov. 2013, Japanese, Annual Congress of Japan Surgical Association, 名古屋, Domestic conference胸腔鏡併用咽頭喉頭食道全摘術の治療成績Oral presentation
- The Latest Advances in Gastric Cancer Research, Nov. 2013, Japanese, 東京, Domestic conferenceDirect cancer-stromal interaction increases fibroblast proliferation and enhances invasive properties of scirrhous-type gastric carcinoma cellsOral presentation
- Gastric Cancer Conference in Amagasaki, Oct. 2013, Japanese, CHUGAI PHARMACEUTICAL CO.,LTD., 兵庫, Domestic conference分子標的薬を活かす胃癌治療最前線[Invited]Invited oral presentation
- The 66th Annual Scientific Meeting of the Japanese Association for Thoracic Surgery, Oct. 2013, Japanese, THE JAPANESE ASSOCIATION FOR THORACIC SURGERY, 仙台, Domestic conference腹臥位食道切除術と術後肺酸素化に与える影響Oral presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference当科における食道GIST切除症例の検討Poster presentation
- The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conference当院における食道癌術後局所再発症例に対するSalvage化学放射線療法(CRT)の治療成績Oral presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference当院における食道癌術後局所再発症例に対するSalvage化学放射線療法(CRT)の治療成績Poster presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference大腸癌内視鏡切除後の追加外科切除例の検討Poster presentation
- 第51回日本癌治療学会学術集会, Oct. 2013, Japanese, 日本癌治療学会, 京都, 【目的】切除不能大腸癌患者に対する全身化学療法の治療成績は、FOLFIRI/FOLFOXと分子標的治療薬を併用する事で飛躍的に向上し、腫瘍縮小後に手術介入を行うことで、主に肝肺転移症例で長期生存が得られる事が報告されている。只、経過中、治癒切除適応と言えなくても手術介入を希望される症例も存在するため、手術介入の意義は明らかではない。今回、全身化学療法開始後に手術介入を行った症例を抽出し、この治療戦略の意義と有用性を検討した。【方法】1999年7月より2011年4 月まで、切除不能大腸癌と判断され、当科で化学療法を先行した134症例を対象とし、化学療法開始後に手術介入(RFA含む)を試みた症例の背景および治療成績を後方視的に検討した。【成績】全134症例の背景は男性/女性92/42、年齢中央値64(28-83)歳、PS0-1/2-3 125/9例、進行, Domestic conference切除不能大腸癌症例に対する手術介入の有用性Oral presentation
- The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conference進行下部直腸癌症例に対する術前・術後補助化学療法の現状Oral presentation
- 大腸癌治療を考える2013 in Kyoto ~OSの延長を目指して~, Oct. 2013, Japanese, Takeda Pharmaceutical Company Limited, 京都, Domestic conference新たなステージを迎えた大腸癌治療戦略-抗EGFR抗体の意義を考える-[Invited]Invited oral presentation
- colorectal cancer meeting in Fukushima, Oct. 2013, Japanese, Takeda Pharmaceutical Company Limited, 福島, Domestic conference新たなステージを迎えた大腸癌治療戦略-抗EGFR抗体の意義を考える-[Invited]Invited oral presentation
- The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conference食道癌に対する化学放射線療法の現状と展望Oral presentation
- The 72nd Annual Meeting of the Japanese Cancer Association, Oct. 2013, Japanese, JAPANESE CANCER ASSOCIATION, 横浜, Domestic conference食道癌におけるCD204陽性腫瘍関連マクロファージの臨床病理学的検討Poster presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference術前化学放射線療法を行った下部直腸癌の術後補助化学療法の現状と問題点Poster presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference残胃癌手術症例の検討Poster presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference鏡視下手術とVTE対策Oral presentation
- The 11th Annual Meeting of the Japanese Society of Gastroenterological Surgery, Oct. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 東京, Domestic conference基礎疾患を有する大腸癌手術症例の検討Poster presentation
- The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conferenceStageIV切除不能胃癌に対する化学療法後切除症例の検討Oral presentation
- The 51st Annual Meeting of Japan Society of Clinical Oncology, Oct. 2013, Japanese, Japan Society of Clinical Oncology, 京都, Domestic conferenceOS延長を目指した治療戦略[Invited]Invited oral presentation
- The 26th Annual Meeting of the Kinki Society for Endoscopic Surgery, Sep. 2013, Japanese, Kinki Society for Endoscopic Surgery, 奈良, Domestic conference当科における腹腔鏡下側方リンパ節郭清についてOral presentation
- 日本消化器病学会近畿支部第99回例会, Sep. 2013, Japanese, 日本消化器病学会近畿支部, 大阪, 【目的】切除不能大腸癌患者に対する全身化学療法の治療成績は、FOLFIRI/FOLFOXと分子標的治療薬を併用する事で飛躍的に向上し、腫瘍縮小後に手術介入を行うことで、主に肝肺転移症例で長期生存が得られる事が報告されている。只、経過中、治癒切除適応と言えなくても手術介入を希望される症例も存在するため、手術介入の意義は明らかではない。今回、全身化学療法開始後に手術介入を行った症例を抽出し、この治療戦略の意義と有用性を検討した。【方法】1999年7月より2011年4 月まで、切除不能大腸癌と判断され、当科で化学療法を先行した134症例を対象とし、化学療法開始後に手術介入(RFA含む)を試みた症例の背景および治療成績を後方視的に検討した。【成績】全134症例の背景は男性/女性92/42、年齢中央値64(28-83)歳、PS0-1/2-3 125/9例、進行, Domestic conference切除不能大腸癌症例に対する手術介入の有用性Public symposium
- 大腸癌治療を考える会 in Autumu, Sep. 2013, Japanese, Takeda Pharmaceutical Company Limited, 名古屋, Domestic conference新たなステージを迎えた大腸癌治療戦略-抗EGFR抗体の意義を考える-[Invited]Invited oral presentation
- ベクティビックス発売3周年記念講演会, Sep. 2013, Japanese, 長野, Domestic conference新たなステージを迎えた大腸癌治療戦略-抗EGFR抗体の意義を考える-[Invited]Invited oral presentation
- メルクセローノセミナー, Sep. 2013, Japanese, 神戸, Domestic conference消化管領域のロボット支援手術Public discourse
- 1st Japan NeuroEndocrine Tumor Society(JNETS), Sep. 2013, Japanese, Japan NeuroEndocrine Tumor Society(JNETS), 京都, Domestic conference化学放射線療法により完全奏功を得た食道小細胞癌の1例Poster presentation
- 2nd Reduced Port Surgery Forum, Aug. 2013, Japanese, 岩手, Domestic conference当科における右側結腸癌に対する単孔式腹腔鏡下手術の導入について[Invited]Invited oral presentation
- The 11th Annual Meeting of Japanese Society of Medical Oncology, Aug. 2013, Japanese, Japan Society of Medical Oncology, 宮崎, Domestic conference外科療法[Invited]Invited oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference臨床診断T3直腸癌に対する術前化学放射線療法の有用性Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference要望ビデオ33Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference腹腔鏡下直腸低位前方切除術における定型化への試みOral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference腹腔鏡下横行結腸癌手術におけるリンパ節郭清の工夫Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference腹臥位および側臥位食道癌切除における術後呼吸機能への影響についての検討Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference当科におけるMinimally invasive esophagectomyへの取り組みOral presentation
- The 79th Meeting of Japanese Society for Cancer of the Colon and Rectum, Jul. 2013, Japanese, Japan Society for Cancer of the Colon and Rectum, 大阪, Domestic conference大腸癌肝転移切除症例における術前化学療法の意義Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference大腸ESD穿孔後の外科的治療の検討Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference食道癌術後肺合併症対策-当科における取り組みOral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference食道胃接合部癌に対する外科治療の検討[Invited]Invited oral presentation
- The 8th KOBE GIST Seminar, Jul. 2013, Japanese, NOVARTIS, 神戸, Domestic conference今後のGIST治療に関して[Invited]Invited oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference高齢者胃癌に対する外科治療Oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conference鏡視下手術とVTE対策[Invited]Invited oral presentation
- The 68th General Meeting of the Japanese Society of Gastronterological Surgery, Jul. 2013, Japanese, The Japanese Society of Gastroenterological Surgery, 宮崎, Domestic conferenceStageIV大腸癌の原発巣切除におけるリンパ節廓清度、手術アプローチの後治療に与える影響Oral presentation
- ベクティビックス発売3周年記念講演会, Jul. 2013, Japanese, Takeda Pharmaceutical Company Limited, 山形, Domestic conference2013ASCO-GI/ASCO後の抗EGFR抗体による大腸癌治療戦略[Invited]Invited oral presentation
- Expert Meeting「進行・再発大腸癌における1次療法としてのパニツムマブの意義を考える」, Jul. 2013, Japanese, Takeda Pharmaceutical Company Limited, 熊本, Domestic conference2013ASCO-GI/ASCO後の抗EGFR抗体による大腸癌治療戦略[Invited]Invited oral presentation
- The 22nd Annual Meeting of Japanese Society of Strategies for Cancer Research and Therapy, Jun. 2013, Japanese, 東京, Domestic conference肺転移における骨髄由来抑制性細胞の役割Oral presentation
- The 67th Annual Meeting of the Japan Esophageal Society, Jun. 2013, Japanese, Annual Meeting of the Japan Esophageal Society, 大阪, Domestic conference当科における腹臥位食道切除術の定型化と術後酸素化に及ぼす影響Oral presentation
- ベクティビックス全国TV/Web講演会ASCO2013 消化器癌治療のトピックス, Jun. 2013, Japanese, 神戸, Domestic conference専門医が注目するASCO2013最新の話題Oral presentation
- 第102回日本病理学会総会, Jun. 2013, Japanese, 日本病理学会, 札幌, Domestic conference食道扁平上皮癌の増殖、進展と腫瘍組織内CD204陽性マクロファージの関連Poster presentation
- The 67th Annual Meeting of the Japan Esophageal Society, Jun. 2013, Japanese, Annual Meeting of the Japan Esophageal Society, 大阪, Domestic conference食道癌手術における3D-CTによる気管支動脈走行の術前ナビゲーションOral presentation
- 第210回大分県外科医会例会, Jun. 2013, Japanese, 大分県外科医会, 大分, Domestic conference食道胃腸外科の集学的治療の現状と展望[Invited]Invited oral presentation
- 第13回播州消化器癌手術手技研究会, Jun. 2013, Japanese, 播州消化器癌手術手技研究会、中外製薬株式会社, 姫路, Domestic conference胃癌に対するコンピューター支援手術[Invited]Invited oral presentation
- 21st International Congress of the European Association for Endoscopic Surgery, Jun. 2013, English, Vienna, Austria, International conferenceSTEP-BY-STEP INTRODUCTION OF REDUCED-PORT LAPAROSCOPIC RIGHT HEMICOLECTOMY-FINAL STAGE-SINGLE INCISION PLUS ONE PUNCTURE LAPAROSCOPIC SURGERY-Poster presentation
- The 38th Annual Congress of Japanese College of Surgeons, Jun. 2013, Japanese, 東京, Domestic conferenceS-1/CDDPによるdown staging後根治切除をし得た切除不能進行胃癌の1例Poster presentation
- 第85回日本消化器内視鏡学会総会, May 2013, Japanese, 日本消化器内視鏡学会, 京都, Domestic conference膜性腎症合併早期胃がんに対するESD後、狭窄を来たし、外科的バイパス術を要した1例Poster presentation
- 大腸癌治療カンファレンス in 川越, May 2013, Japanese, 埼玉, Domestic conference分子標的薬を用いた大腸癌治療戦略2013[Invited]Invited oral presentation
- The 67th Annual Meeting of Japanese Society for Advancement of Surgical techniques, May 2013, Japanese, Japanese Society for Advancement of Surgical Techniques, 北海道, Domestic conference直腸低位前方切除術においてda Vinci surgical systemを用いたsingle stapling techniqueによる吻合[Invited]Invited oral presentation
- The 35th annual meeting of Japanese Scociety for Resarch of Loco-Regional Cancer Therapy, May 2013, Japanese, Japanese Society for Research of Loco-Regional Cancer Therapy, 神戸, Domestic conference大腸癌肝転移に対する切除前化学療法施行の検討Oral presentation
- The 35th annual meeting of Japanese Scociety for Resarch of Loco-Regional Cancer Therapy, May 2013, Japanese, Japanese Society for Research of Loco-Regional Cancer Therapy, 神戸, Domestic conference食道癌術前補助化学療法におけるmGPSの意義Oral presentation
- The 35th annual meeting of Japanese Scociety for Resarch of Loco-Regional Cancer Therapy, May 2013, Japanese, Japanese Society for Research of Loco-Regional Cancer Therapy, 神戸, Domestic conference化学療法にて手術可能となった切除不能胃癌の4例Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference腹腔鏡下横行結腸癌手術におけるリンパ節郭清の工夫Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference腹会陰式直腸切断術に対する腹腔鏡下大網形成術の有用性/直腸癌の術前化学放射線療法後の合併症対策としてPoster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference腹臥位胸腔鏡下食道切除術におけるトラブルシューティングOral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference肺転移における骨髄由来抑制細胞(MDSC)の役割についてPoster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference超高齢者胃癌の外科治療の問題点と可能性Poster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference大腸癌領域における分子標的治療薬の最新情報Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference大腸癌肝転移症例における、化学療法後の肝切除術の有用性Poster presentation
- 市民公開講座「がんに負けないためには」, Apr. 2013, Japanese, 神戸, Domestic conference大腸がんとは[Invited]Invited oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference食道切除後の胸壁前経路有茎空腸再建術の有用性Poster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference食道癌手術治療における静脈血栓寒栓症予防対策の確立Poster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference食道癌手術における3D-CTによる気管支動脈走行形態ナビゲーションの有用性Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference食道癌に対する腹腔鏡補助下胃管再建術の治療成績Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference食道癌cStageII/IIIで術前補助化学療法を施行した症例におけるModified Glasgow Prognostic Score(mGPS)の有用性Poster presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference消化器外科領域における臨床研究の現状Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference簡便性と安全性を追求した腹腔鏡下直腸切除術-当科での工夫と定型化への試み-Oral presentation
- The 113th Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, Japan Surgical Society, 福岡, Domestic conference胃癌腹膜播腫に対する治療と展開Oral presentation
- THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC SURGERY(ASCVTS), Apr. 2013, Japanese, 神戸, Domestic conferencePRONE THORACOSCOPIC ESOPHAGECTOMY AND IMPROVEMENT OF POSTOPERATIVE PULMONARY OXYGENATION[Invited]Invited oral presentation
- THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC SURGERY, Apr. 2013, Japanese, 神戸, Domestic conferencePRONE THORACOSCOPIC ESOPHAGECTOMY AND IMPROVEMENT OF POSTOPERATIVE PULMONARY OXYGENATION[Invited]Invited oral presentation
- GIST forum 2013, Apr. 2013, Japanese, 福島, Domestic conferenceGIST新ガイドラインに基づいた集学的治療[Invited]Invited oral presentation
- The 49th Annual Congress of Japanese Society for Abdominal Emergency Medicine, Mar. 2013, Japanese, Japanese Society for Abdominal Emergency Medicine, 福岡, Domestic conference腹腔鏡下回盲部切除術にて治療できた腸腰筋膿瘍を形成した虫垂炎の一例Oral presentation
- 第11回神戸内視鏡外科手術手技研究会, Mar. 2013, Japanese, Kobe University Hospital Medical, 神戸, Domestic conference特別講演会、animal Labによる技術指導Public discourse
- The 46th Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, Mar. 2013, Japanese, Japan Research Society for Appropriate Cancer Chemotherapy, 軽井沢, Domestic conference大腸癌術後補助化学療法の変遷に関する調査~多施設アンケートをもとにOral presentation
- これからの大腸癌治療~ベクティビックス全例調査結果を受けて~, Mar. 2013, Japanese, Takeda Pharmaceutical Company Limited, 尼崎, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略のエビデンス-Public discourse
- 北大阪大腸がん化学療法カンファレンス, Mar. 2013, Japanese, Merck Serono, 大阪, Domestic conference大腸癌治療における抗EGFR抗体を用いた治療戦略Public discourse
- The 49th Annual Congress of Japanese Society for Abdominal Emergency Medicine, Mar. 2013, Japanese, Japanese Society for Abdominal Emergency Medicine, 福岡, Domestic conference食道穿孔に対する胸腔鏡下食道切除術Oral presentation
- 第9回兵庫胃がん治療研究会, Mar. 2013, Japanese, 兵庫胃がん治療研究会、兵庫県がん診療連携協議会、大鵬薬品工業株式会社, 神戸, Domestic conference手術:No,16郭清~私はこうしている~Public discourse
- The 46th Annual Meeting of Japan Research Society for Appropriate Cancer Chemotherapy, Mar. 2013, Japanese, Japan Research Society for Appropriate Cancer Chemotherapy, 軽井沢, Domestic conference高齢者におけるStageIII大腸癌に対する術後補助化学療法の現況Oral presentation
- 第20回近畿大腸肛門疾患カンファレンス, Mar. 2013, Japanese, 近畿大腸肛門疾患カンファレンス、大鵬薬品工業株式会社, 大阪, Domestic conference経口抗癌剤を用いた大腸癌術後補助化学療法Public discourse
- 第99回日本消化器病学会総会, Mar. 2013, Japanese, 日本消化器病学会, 鹿児島, 切除不能再発・進行胃癌患者の当科における化学療法の成績を一次治療から検討し、その中で手術転換を行い得た症例を後方視的に評価した。2000年6月~2010年11月までの予後評価可能108症例を対象とし、全生存成績は342日、10例以上の治療経験レジメンは一次治療別レジメン(S-1/5FU/CPT-11+CDDP/S-1+CDDP/S-1+DTX)では大きな差を認めなかった。手術転換症例は4例、加療前非治癒因子は肺転移1/#16リンパ節転移2/BulkyN2転移1であった。R0切除後無再発生存が2例(#16リンパ節転移とBulkyN2)、どちらもS-1+αレジメンであった。現行の2剤併用レジメンで手術転換が可能となり、救済できたのは高度リンパ節転移例に限られており、現在3剤併用のDCSの手術転換率を検証する臨床試験の結果が期待される。, Domestic conference一時治療から見た当科における胃癌化学療法患者の治療成績について―手術転換例を中心に―Poster presentation
- The 99th General Meeting of the Japanese Society of Gastroenterology, Mar. 2013, Japanese, The Japanese Society of Gastroenterology, 鹿児島, Domestic conference胃癌周術期補助化学療法の進歩~S-1+αの可能性~Oral presentation
- The 49th Annual Congress of Japanese Society for Abdominal Emergency Medicine, Mar. 2013, Japanese, Japanese Society for Abdominal Emergency Medicine, 福岡, Domestic conference胃・十二指腸潰瘍穿孔の治療法 -手術or保存療法-Others
- 第9回兵庫胃がん治療研究会, Mar. 2013, Japanese, 兵庫胃がん治療研究会、兵庫県がん診療連携協議会、大鵬薬品工業株式会社, 神戸, Domestic conferenceーPublic discourse
- 大腸がん副作用マネジメント勉強会, Mar. 2013, Japanese, Takeda Pharmaceutical Company Limited, 埼玉, Domestic conferenceCureを目指したフロントラインからの大腸癌治療戦略Public discourse
- 神戸大腸癌術後補助化学療法フォーラム, Mar. 2013, Japanese, 神戸, Domestic conference--Public discourse
- The 85th Annual Meeting of Japanese Gastric Cancer Association, Feb. 2013, Japanese, Japanese Gastric Cancer Association, 大阪, Domestic conference病理病期II,IIIA,IIIB進行胃癌術後補助化学療法Docetaxel/S-1併用療法の安全確認試験-予後追跡調査-Oral presentation
- 日本消化器病学会近畿支部第98回例会, Feb. 2013, Japanese, 日本消化器病学会近畿支部, 神戸, Domestic conference当院における後期高齢者食道癌の内科的及び外科的治療の展開Public symposium
- 胃癌・大腸癌検診部会定例講演会, Feb. 2013, Japanese, 明石医師会、武田薬品工業株式会社, 明石, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略のエビデンス-Public discourse
- 第2回最新の大腸癌治療を考える会, Feb. 2013, Japanese, Takeda Pharmaceutical Company Limited, 大阪, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略-Keynote oral presentation
- ベクティビックス講演会 ~切除不能大腸癌フロントライン治療におけるベクティビックスの位置づけ~, Feb. 2013, Japanese, Takeda Pharmaceutical Company Limited, 福岡, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略-Public discourse
- 第17回消化器癌フォーラム, Feb. 2013, Japanese, TAIHO PHARMACEUTICAL CO, 大阪, Domestic conference大腸癌の最新集学的治療戦略Public discourse
- The 85th Annual Meeting of Japanese Gastric Cancer Association, Feb. 2013, Japanese, Japanese Gastric Cancer Association, 大阪, Domestic conference高齢者の早期胃癌に対する腹腔鏡補助下幽門側胃切除術の検討Oral presentation
- The 85th Annual Meeting of Japanese Gastric Cancer Association, Feb. 2013, Japanese, Japanese Gastric Cancer Association, 大阪, Domestic conference胸腔鏡下食道癌手術後胃管癌の2切除例の報告Poster presentation
- 第85回日本胃癌学会総会, Feb. 2013, Japanese, 日本胃癌学会, 大阪, 切除不能再発・進行胃癌患者の当科における化学療法の成績を一次治療から検討し、その中で手術転換を行い得た症例を後方視的に評価した。2000年6月~2010年11月までの予後評価可能108症例を対象とし、全生存成績は342日、10例以上の治療経験レジメンは一次治療別レジメン(S-1/5FU/CPT-11+CDDP/S-1+CDDP/S-1+DTX)では大きな差を認めなかった。手術転換症例は4例、加療前非治癒因子は肺転移1/#16リンパ節転移2/BulkyN2転移1であった。R0切除後無再発生存が2例(#16リンパ節転移とBulkyN2)、どちらもS-1+αレジメンであった。現行の2剤併用レジメンで手術転換が可能となり、救済できたのは高度リンパ節転移例に限られており、現在3剤併用のDCSの手術転換率を検証する臨床試験の結果が期待される。, Domestic conference一次治療から見た当科における胃癌化学療法患者の治療成績について-手術転換例を中心に-Oral presentation
- The 85th Annual Meeting of Japanese Gastric Cancer Association, Feb. 2013, Japanese, Japanese Gastric Cancer Association, 大阪, Domestic conference胃GISTに対する単孔式腹腔鏡下手術Oral presentation
- 大腸癌治療セミナー, Feb. 2013, Japanese, Yakult Honsha Co, 神戸, Domestic conferenceーPublic discourse
- 阪神消化管治療研究会, Feb. 2013, Japanese, TAIHO PHARMACEUTICAL CO, 神戸, Domestic conferenceーPublic discourse
- 臨床研究を考える会, Jan. 2013, Japanese, Takeda Pharmaceutical Company Limited, 横浜, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略-Public discourse
- ベクティビックス講演会 大腸癌治療を適正に実施するために, Jan. 2013, Japanese, Takeda Pharmaceutical Company Limited, 福島, Domestic conference大腸癌治療の新展開-Cureを目指したフロントライン治療戦略-Public discourse
- The 78th Meeting of Japanese Society For Cancer of the Colon and Recturm, Jan. 2013, Japanese, Japanese Society For Cancer of the Colon and Recturm, 東京, Domestic conference局所進行直腸癌治療と腹会陰式直腸切除術会陰部創管理における大網形成術の有用性Oral presentation
- The 5th Annual Congress of Japan Robotic Surgery Society, Jan. 2013, Japanese, Japan Robotic Surgery Society, 名古屋, Domestic conferenceロボット支援幽門側胃切除術における3D-HD映像と多関節機能の活用Oral presentation
- The 25th Annual Meeting of the Japan Society for Endoscopic Surgery, Dec. 2012, Japanese, Japan Society for Endoscopic Surgery, 横浜, Domestic conference腹臥位食道切除術における術中体位の問題点-神経障害を中心として-Oral presentation
- The 25th Annual Meeting of the Japan Society for Endoscopic Surgery, Dec. 2012, Japanese, Japan Society for Endoscopic Surgery, 横浜, Domestic conference腹臥位胸腔鏡下食道切除術における縦隔郭清の工夫と手術成績Oral presentation
- The 25th Annual Meeting of the Japan Society for Endoscopic Surgery, Dec. 2012, Japanese, Japan Society for Endoscopic Surgery, 横浜, Domestic conference当科における腹腔鏡下側方リンパ節郭清についてOral presentation
- The 25th Annual Meeting of the Japan Society for Endoscopic Surgery, Dec. 2012, Japanese, Japan Society for Endoscopic Surgery, 横浜, Domestic conference高齢者に対する腹腔鏡補助下幽門側胃切除術の検討Oral presentation
- 第15回神戸外科フォーラム, Dec. 2012, Japanese, 神戸外科フォーラム、大鵬薬品工業株式会社, 横浜, Domestic conferenceーPublic discourse
- The 67th Annual Meeting of the Japan Society of Coloproctology, Nov. 2012, Japanese, Japan Society of Coloproctology, 福岡, Domestic conferenceStageIV大腸癌の原発巣切除に対する腹腔鏡下手術の有用性Oral presentation
- The192st Annual Conference of Kinki Surgical Association, Nov. 2012, Japanese, Kinki Surgical Association, 大阪, Domestic conference頸部食道choristomaの一例Oral presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference腹腔鏡下胃全摘術・噴門切除術とその再建術式2Others
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference当科における食道GISTの治療経験Oral presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference当科における残胃癌に対する手術成績の検討Oral presentation
- The 23th Annual Meeting of Japanese Society for Gastroenterological Carcinogenesis, Nov. 2012, Japanese, Japanese Society for Gastroenterological Carcinogenesis, 徳島, Domestic conference当科において経験した食道GIST切除症例の検討Oral presentation
- The 46th Annual Meeting of Nagoya Colorectal Cancer Seminar, Nov. 2012, Japanese, Nagoya Colorectal Cancer Seminar、Takeda Pharmaceutical Company Limited, 名古屋, Domestic conference大腸癌治療の今~Cureを目指したフロントライン治療戦略~Public discourse
- 第10回神戸消化器外科懇話会, Nov. 2012, Japanese, 兵庫医科大学肝胆膵外科、神戸消化器外科懇話会、大塚製薬株式会社、イーエヌ大塚製薬株式会社, 神戸, Domestic conference大腸癌の最新治療戦略[Invited]Invited oral presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference多施設アンケート調査による大腸癌補助化学療法の変遷の評価~兵庫大腸癌治療研究会Oral presentation
- 日本消化器内視鏡学会近畿支部第89会支部例会, Nov. 2012, Japanese, 日本消化器内視鏡学会近畿支部, 大阪, Domestic conference診断に難渋した原発性虫垂癌の一例Oral presentation
- The 67th Annual Meeting of the Japan Society of Coloproctology, Nov. 2012, Japanese, Japan Society of Coloproctology, 福岡, Domestic conference出血を来した小腸滑膜肉腫の1例Poster presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference胸腔鏡下食道切除術をおこなった右鎖骨下動脈起始異常を伴う食道癌の一例Oral presentation
- The192st Annual Conference of Kinki Surgical Association, Nov. 2012, Japanese, Kinki Surgical Association, 大阪, Domestic conference回腸癌の術前診断で切除術を施行した虫垂癌回腸浸潤の一例Oral presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference下部消化管穿孔症例におけるincisional SSIの予防に対するJ-VAC Drainage Systemの効果についてOral presentation
- The 74th Annual Congress of Japan Surgical Association, Nov. 2012, Japanese, Japan Surgical Association, 東京, Domestic conference胃領域リンパ節に転移を認めた悪性黒色腫胃転移の1切除例Oral presentation
- 神戸消化器外科手術フォーラム, Nov. 2012, Japanese, Chugai Pharmaceutical Co, 神戸, Domestic conference胃癌のRobotic SurgeryPublic discourse
- The 23th Annual Meeting of Japanese Society for Gastroenterological Carcinogenesis, Nov. 2012, Japanese, Japanese Society for Gastroenterological Carcinogenesis, 徳島, Domestic conferenceマウス膵癌細胞を用いた制御性T細胞除去と樹状細胞ワクチン併用療法の抗腫瘍効果に関する検討Oral presentation
- The 23th Annual Meeting of Japanese Society for Gastroenterological Carcinogenesis, Nov. 2012, Japanese, Japanese Society for Gastroenterological Carcinogenesis, 徳島, Domestic conferenceヒトアロ樹状細胞を用いたCTL誘導の試みOral presentation
- Challenges for the Future of Colorectal Cancer, Nov. 2012, Japanese, Takeda Pharmaceutical Company Limited, 東京, Domestic conferenceThe Optimal Treatment of Aggressive approachPublic discourse
- Challenges for the Future of Colorectal Cancer, Nov. 2012, Japanese, Takeda Pharmaceutical Company Limited, 東京, Domestic conferenceOncosurgical approachとsurvival benefitPublic discourse
- The 67th Annual Meeting of the Japan Society of Coloproctology, Nov. 2012, Japanese, Japan Society of Coloproctology, 福岡, Domestic conference-Others
- The 23th Annual Meeting of Japanese Society for Gastroenterological Carcinogenesis, Nov. 2012, Japanese, Japanese Society for Gastroenterological Carcinogenesis, 徳島, Domestic conference-Others
- 神戸消化器外科手術フォーラム, Nov. 2012, Japanese, Chugai Pharmaceutical Co, 神戸, Domestic conference-Public discourse
- 第10回神戸内視鏡外科手術手技研究会, Oct. 2012, Japanese, Kobe University Hospital Medical Information Network, 神戸, Domestic conference特別講演・内視鏡外科手術 Hands on seminarPublic discourse
- The 50th Annual Meeting of Japan Society of Clinical Oncology, Oct. 2012, Japanese, Japan Society of Clinical Oncology, 横浜, Domestic conference直腸癌における側方リンパ節に対する術前化学放射線療法の治療効果Oral presentation
- 第4回四国消化器癌フォーラム, Oct. 2012, Japanese, 四国消化器癌フォーラム、株式会社ヤクルト本社、徳島大学病院がん診療連携センター, 徳島, Domestic conference大腸癌術後補助化学療法の現状Public discourse
- 第50回日本癌治療学会学術集会, Oct. 2012, Japanese, 日本癌治療学会, 横浜, Domestic conference進行再発大腸癌のCetuximab単剤・併用療法例の効果、安全性および早期効果予測の検討Poster presentation
- The 50th Annual Meeting of Japan Society of Clinical Oncology, Oct. 2012, Japanese, Japan Society of Clinical Oncology, 横浜, Domestic conference進行再発大腸癌に対する薬剤による組織学的的効果と治療戦略-大腸外科の立場から-Oral presentation
- 第50回日本癌治療学会学術集会, Oct. 2012, Japanese, 日本癌治療学会, 横浜, Domestic conference新規抗癌剤治療を行ったS状結腸腺扁平上皮癌多発肝転移の1例Poster presentation
- 第4回四国消化器癌フォーラム, Oct. 2012, Japanese, 四国消化器癌フォーラム、株式会社ヤクルト本社、徳島大学病院がん診療連携センター, 徳島, Domestic conference治癒を目指す大腸癌術後補助化学療法2012Public discourse
- The 50th Annual Meeting of Japan Society of Clinical Oncology, Oct. 2012, Japanese, Japan Society of Clinical Oncology, 横浜, Domestic conferenceStagelV大腸癌原発巣切除例の検討Oral presentation
- The 50th Annual Meeting of Japan Society of Clinical Oncology, Oct. 2012, Japanese, Japan Society of Clinical Oncology, 横浜, Domestic conference-Others
- The 20st Annual Meeting of Japan Digestive Disease Week, Oct. 2012, Japanese, Japan Digestive Disease Week, 神戸, Domestic conference-Others
- 神戸消化器癌フォーラム, Oct. 2012, Japanese, TAIHO PHARMACEUTICAL CO, 神戸, Domestic conference-Public discourse
- The 25th Anuual Meeting of the Kinki Society for Endoscopic Surgery, Sep. 2012, Japanese, the Kinki Society for Endoscopic Surgery, 京都, Domestic conference腹臥位胸腔鏡下食道切除におけるトラブルシューティングOral presentation
- 日本消化器病学会近畿支部第97回例会, Sep. 2012, Japanese, 日本消化器病学会近畿支部, 京都, Domestic conference同時多発癌を合併したCrohn病の一例Oral presentation
- 第2回 M:I Meeting with surgeon & Oncologist, Sep. 2012, Japanese, Merck Serono, 神戸, Domestic conference大腸がん治療における抗EGFR抗体を用いた治療戦略Public discourse
- The 71st Annual Meeting of the Japanese Cancer Association, Sep. 2012, Japanese, the Japanese Cancer Association, 北海道, Domestic conference消化器がんの分子標的治療薬Others
- 広畑・癌治療・化学療法セミナー, Sep. 2012, Japanese, ONO PHARMACEUTICAL CO, 姫路, Domestic conference患者にやさしい大腸がん化学療法Public discourse
- The 71st Annual Meeting of the Japanese Cancer Association, Sep. 2012, Japanese, the Japanese Cancer Association, 北海道, Domestic conferenceトリプルネガティブ乳癌におけるBRCA1プロモーターメチル化の臨床的意義Oral presentation
- 日本消化器病学会近畿支部第97回例会, Sep. 2012, Japanese, 日本消化器病学会近畿支部, 京都, 切除不能再発・進行胃癌患者の当科における化学療法の成績を一次治療から検討し、その中で手術転換を行い得た症例を後方視的に評価した。2000年6月~2010年11月までの予後評価可能108症例を対象とし、全生存成績は342日、10例以上の治療経験レジメンは一次治療別レジメン(S-1/5FU/CPT-11+CDDP/S-1+CDDP/S-1+DTX)では大きな差を認めなかった。手術転換症例は4例、加療前非治癒因子は肺転移1/#16リンパ節転移2/BulkyN2転移1であった。R0切除後無再発生存が2例(それぞれ#16リンパ節転移とBulkyN2)、どちらもS-1+αレジメンであった。現行の2剤併用レジメンで手術転換が可能となり、救済できたのは高度リンパ節転移例に限られており、現在3剤併用のDCSの手術転換率を検証する臨床試験の結果が期待される。, Domestic conference1次治療から見た当科における胃癌化学療法患者の治療成績について-手術転換例を中心に-Public symposium
- The 97st Annual Meeting of THE JAPANESE SOCIETY OF GASTROENTEROLOGY, Sep. 2012, Japanese, THE JAPANESE SOCIETY OF GASTROENTEROLOGY, 京都, Domestic conference1次治療から見た当科における胃癌化学療法患者の治療成績について-手術転換例を中心に-Public symposium
- Colorectal Cancer Symposium in KOBE 2012, Sep. 2012, Japanese, Yakult Honsha Co, 神戸, Domestic conference-Public discourse
- 神戸大学連携授業, Aug. 2012, Japanese, Kobe University Hospital Medical, 神戸, Domestic conference内視鏡外科手術体験コースPublic discourse
- 2012 World Congress on Gastrointestinal Cancer:Asian Perspectives, Aug. 2012, English, Imedex, 中国, Domestic conferenceLuncheon Satellite SymposiumOral presentation
- 神戸大学連携授業, Aug. 2012, Japanese, Kobe University Hospital Medical, 神戸, Domestic conference21世紀のロボット手術Public discourse
- 大腸癌治療 Update in Kobe, Aug. 2012, Japanese, Yakult Honsha Co, 神戸, Domestic conference-Public discourse
- Covidien Japan Hand-on Training, Aug. 2012, Japanese, Covidien company, 神戸, Domestic conference-Public discourse
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference大腸癌肝転移における完全腹腔鏡下肝切除および大腸同時切除術[Invited]Invited oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference大腸癌におけるDNA修腹因子FANCJ発現と5-FU感受性[Invited]Invited oral presentation
- The75th Annual Congress of Japanese Society for Cancer of the Colon and Rectum, Jul. 2012, Japanese, Japanese Society for Cancer of the Colon and Rectum, 東京, Domestic conference大腸癌StageIVにおけるFanconi貧血経路およびミスマッチ修復経路活性化の意義Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略2012Others
- Vectibix発売2周年記念Symposium in NAHA, Jul. 2012, Japanese, Takeda Pharmaceutical Company Limited, 沖縄, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- TAKEDA大腸がんセミナー~Panitumumabの位置づけを考える~, Jul. 2012, Japanese, Takeda Pharmaceutical Company Limited, 岩手, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference新たに開発した直腸圧排鉤を用いた腹腔鏡下直腸吻合方法″Push法、Push & Pull法゛の検討Others
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference食道癌におけるDNA修復遺伝子FANCJ発現の意義Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference食道癌Salvage手術の検証からの治療戦略Others
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference完全腹腔鏡下幽門側胃切除における三角吻合(Book Binding法)の工夫Others
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference胃癌腹膜播種に対する審査腹腔鏡の有用性とS-1+Docetaxel術前化学療法による集学的治療戦略Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference胃癌のHER2診断における問題点の検証Others
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference胃癌における染色体不安定性に対するMad2過剰発現の影響Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference胃癌における細胞周期の制御因子Plk1過剰発現と染色体不安定性の関連Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference胃・大腸癌組織におけるCXCL12/CXCR4発現による浸潤転移の分子機序とその制御Others
- The 77th Annual Congress of, Jul. 2012, Japanese, Japanese Society for Cancer of the Colon and Rectum, 東京, Domestic conferenceーOthers
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conferenceワークショップ1-2B:臨床応用に向かう消化器外科領域基礎研究(消化管)Others
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conferenceハイパースペクトルカメラを用いた大腸病変における酸化ヘモグロビンの濃度変化に関する検討Oral presentation
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conferenceコンピューター診断支援システムNewVESを応用した消化器外科領域の治療シミュレーションOthers
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conferenceWT1およびMUC1がん抗原ペプチドを用いた進行膵癌に対する樹状細胞ワクチン療法Others
- 第36回京大外科関連施設癌研究会, Jul. 2012, Japanese, 京大外科関連施設癌研究会、中外製薬株式会社, 京都, Domestic conferenceHER2検査を導入した胃癌治療の最前線~HER2 陰性症例~Public discourse
- 第7回神戸GISTセミナー, Jul. 2012, Japanese, Novartis Pharma, 神戸, Domestic conferenceGIST治療の将来展望Public discourse
- The 67th General Meeting of the Japanese Society of Gastroenterological Surgery, Jul. 2012, Japanese, The Japanese Society of Gastroenterological Surgery, 富山, Domestic conference80歳以上高齢者胃癌に対する外科治療・成績と術後栄養状態の評価Oral presentation
- The 10th Annual Meeting of Japanese Society of Medical Oncology, Jul. 2012, Japanese, Japanese Society of Medical Oncology, 大阪, Domestic conference-Others
- the 20th International Congress of the European Association for Endoscopic Surgery (EAES) in Brussels, Jun. 2012, Japanese, ベルギー, International conferencelaparoscopic harvest of perineal omentplasty wtih rectal resection for rectal cancerOthers
- The 66th Annual Meeting of The Japan Esophageal Society, Jun. 2012, Japanese, The Japan Esophageal Society, 軽井沢, Domestic conference-Others
- 市民公開講座 もし大腸がんになったら~これだけ知ればもう安心~, Jun. 2012, Japanese, EAES, 神戸, Domestic conference-Public discourse
- 第三回ベクティビックス適生使用勉強会, May 2012, Japanese, Takeda Pharmaceutical Company Limited, 長崎, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- the193st Annual Conference of Fukuyama Surgical Association, May 2012, Japanese, Fukuoka Surgical Association, 福山, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- ベクティビックス講演会, May 2012, Japanese, Takeda Pharmaceutical Company Limited, 北海道, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- Vectibix発売2周年記念講演会, May 2012, Japanese, Takeda Pharmaceutical Company Limited, 鹿児島, Domestic conference進行・再発大腸癌におけるCureを目指したフロントライン治療戦略Public discourse
- Chugai Colorectal Cancer Symposium in KOBE, May 2012, Japanese, Chugai Pharmaceutical Co, 神戸, Domestic conference結腸癌術後化学療法の新たな選択肢と治療選択Public discourse
- 兵庫IBDカンファレンス, May 2012, Japanese, 神戸, Domestic conferenceクローン病発症から23年を経て同時性多発大腸癌を併発した1例Public discourse
- The 66th Annual Meeting of Japanese Society for Advanvemem of Suegical Techniques, May 2012, Japanese, Japanese Society for Advanvemem of Suegical Techniques, 福岡, Domestic conference-Others
- the 51st Annual Conference of Japanese Society for Medical and Biological Engineering, May 2012, Japanese, Japanese Society for Medical and Biological Engineering, 福岡, Domestic conference-Others
- Japanese Study Group on GIST, Apr. 2012, Japanese, Japanese Study Group on GIST, 大阪, Domestic conference進化するGIST集学的治療戦略Public discourse
- 第15回近畿腹腔鏡下胃切除セミナー, Japanese, 近畿腹腔鏡下胃切除セミナー/コヴィディエンジャパン株式会社, 大阪, Domestic conference特別講演「本当に膵液瘻がゼロになる!サーモグラフィーで考える腹腔鏡下胃切除術」Others
- American Society for Clinical Oncology (ASCO)
- American Association for Cancer Research (AACR)
- 日本胃癌学会
- American Society of Clinical Oncology (ASCO)
- 日本コンピュ−タ外科学会
- 日本内視鏡外科学会
- 日本消化器癌発生学会
- 日本食道学会
- 日本サイトメトリー学会
- American Association for Cancer Research (AACR)
- 日本消化器内視鏡学会
- 日本癌学会
- 日本癌治療学会
- 日本消化器外科学会
- 日本外科学会
- 日本学術振興会, 科学研究費助成事業 基盤研究(B), 基盤研究(B), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023胃癌腫瘍免疫微小環境における3次リンパ構造の成熟機構の解明と抗体取得
- 科学研究費補助金/基盤研究(B), Apr. 2018 - Mar. 2022Competitive research funding
- 学術研究助成基金助成金/挑戦的研究(萌芽), Jun. 2018 - Mar. 2021, Principal investigatorCompetitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2017 - Mar. 2020Competitive research funding
- 科学研究費補助金/基盤研究(B), Apr. 2016 - Mar. 2020, Principal investigatorCompetitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2016 - Mar. 2019Competitive research funding
- 学術研究助成基金助成金/挑戦的萌芽研究, Apr. 2016 - Mar. 2019Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2015 - Mar. 2018Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2015 - Mar. 2018Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2015 - Mar. 2018Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2014 - Mar. 2017Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2013 - Mar. 2017Competitive research funding
- 国立大学法人岐阜大学, 革新的がん医療実用化研究事業, 2017, Principal investigator(AMED)病理学的Stage II/IIIで“vulnerable”な80歳以上の高齢者胃癌に対する開始量を減量し たS-1術後補助化学療法に関するランダム化比較第III相試験/患者登録とプロトコール治療遂行Competitive research funding
- 地方独立行政法人大阪府立病院機構大阪急性期・総合医療センター, 免疫アレルギー疾患等実用化研究事業, 2017, Principal investigator(AMED)医療の質の向上及び効率化に向けた、肝移植手術におけるリスクモデルの作成とエビデンスの創設Competitive research funding
- 学校法人慶応義塾, 臨床研究等ICT基盤構築・人工知能実装研究事業, 2017, Principal investigator医療の質向上を目的とした臨床データベースの共通プラットフォームの構築Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2013 - Mar. 2016Competitive research funding
- 学術研究助成基金助成金/基盤研究(C), Apr. 2013 - Mar. 2016Competitive research funding
- 科学研究費一部基金/基盤研究(B), Apr. 2012 - Mar. 2016, Principal investigatorCompetitive research funding
- 革新的がん医療実用化研究事業, 2016, Principal investigator(AMED)高度リンパ節転移を有するHER2陽性胃癌に対する術前trastuzumab併用化学療法の意義に関する臨床試験/症例登録の推進・登録状況の確認Competitive research funding
- 学術研究助成基金助成金/挑戦的萌芽研究, Apr. 2012 - Mar. 2015, Principal investigatorCompetitive research funding
- 国立研究開発法人日本医療研究開発機構, 革新的がん医療実用化研究事業, 2015, Principal investigator(AMED)高度リンパ節転移を有するHER2陽性胃癌に対する術前trastuzumab併用化学療法の意義に関する臨床試験Competitive research funding
- 厚生労働科学研究費補助金, 2012, Principal investigator厚生科研「大腸癌におけるオキサリプラチンの末梢神経障害に対する漢方薬:牛車腎気丸の有用性に関する多施設共同二重盲検ランダム化比較検証試験(臨床第Ⅲ相試験)」Competitive research funding
- 科学研究費補助金, 2004 - 2007多次元医用画像誘導による内視鏡下手術支援システムの開発Competitive research funding
- 科学研究費補助金, 2004 - 2006共焦点内視鏡による消化管病変の診断技術の確立Competitive research funding
- Grant-in-Aid for Scientific Research, 2002Angiogenesis and Metastasis in Gastric CancerCompetitive research funding
- Millennium Project, 2001Chemotherapy in Gastric CancerCompetitive research funding