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原田 理沙大学院医学系研究科 医科学専攻助教
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■ 受賞- 2024年03月 日本リハビリテーション医学会, 国際誌論文賞優秀論文賞, Predictors of Activities of Daily Living in Intensive Care Unit Survivors: A Propensity Score Matching Analysis
- 2024年03月 Progress in Rehabilitation Medicine, Best Reviewer Award, Progress in Rehabilitation Medicine
- 2018年10月 日本リハビリテーション医学会基礎研究Special Intarest Group, 第53回日本リハビリテーション医学会学術集会基礎研究Special Intarest Group優秀演題賞, 炭酸ガス経皮吸収は、腱炎の治癒を促進する
- CONTEXT: Once-weekly somapacitan is approved for treating adults with growth hormone deficiency. Phase 3 trials support its non-inferiority to daily growth hormone (GH); however, its effect on comprehensive metabolic outcome, including muscle strength, during routine care, remains unclear. OBJECTIVE: To compare the metabolic and functional outcomes in patients who switched from daily GH to somapacitan with those who continued daily GH. DESIGN: Prospective, observational, non-randomized comparative study conducted from baseline to 52 weeks. SETTING: A single-center providing routine endocrine management. PATIENTS: Fifty-seven adults on growth hormone replacement therapy were self-selected to receive either once-weekly or continued daily GH. INTERVENTION: Switching from daily GH to once-weekly somapacitan, or continuing daily treatment based on patient preference. MAIN OUTCOME MEASURES: The prespecified primary endpoint was the dual-energy x-ray absorptiometry-derived change in total lean mass from baseline to week 52. Exploratory endpoints included body composition, lipid profile, and physical performance. RESULTS: Baseline and week 52 insulin-like growth factor 1 standard deviation scores distributions were similar between the groups; yet the increase was greater with daily GH than with somapacitan. The primary endpoint showed no between-group difference (mean difference -0.2 kg; 95% CI -1.5 to 1.1). Somapacitan was associated with increased adiposity indices, yet it improved high-density lipoprotein-cholesterol. Exploratory analyses revealed improvements in handgrip strength and Timed Up and Go Test. No new safety concerns were observed. CONCLUSIONS: In routine practice, switching to once-weekly somapacitan was associated with improved functional outcomes, despite less favorable adiposity trajectories, compared with daily therapy. Further studies are required to clarify long-term effects.2026年04月, The Journal of clinical endocrinology and metabolism, 英語, 国際誌研究論文(学術雑誌)
- (一社)日本内分泌学会, 2025年10月, 日本内分泌学会雑誌, 101(2) (2), 657 - 657, 日本語Weekly GHへの切替が代謝、筋肉に与える影響
- (一社)日本義肢装具学会, 2025年10月, 日本義肢装具学会誌, 41(特別) (特別), 150 - 150, 日本語小児に対するカーボン製三層式後方支柱付き短下肢装具装着時の歩行機能と使用満足度の評価
- (一社)日本義肢装具学会, 2025年10月, 日本義肢装具学会誌, 41(特別) (特別), 174 - 174, 日本語進行性痙性麻痺におけるカーボン製三層式後方支柱付き短下肢装具の適応とその限界 2症例による定量的検討
- (一社)日本義肢装具学会, 2025年10月, 日本義肢装具学会誌, 41(特別) (特別), 180 - 180, 日本語エーラス・ダンロス症候群における脊柱非対称例に対する足底装具が脊柱および歩行機能に与える影響の検討
- (一社)日本内分泌学会, 2025年10月, 日本内分泌学会雑誌, 101(2) (2), 657 - 657, 日本語Weekly GHへの切替が代謝、筋肉に与える影響
- RATIONALE: Hereditary spastic paraplegia (HSP), a rare neurodegenerative disorder in Japan, is characterized by insidiously progressive lower extremity spasticity and muscle weakness. Current management is primarily symptomatic, including physical therapy and spasticity modulation with botulinum toxin or intrathecal baclofen. Recent studies have suggested that extracorporeal shock wave therapy (ESWT) may be effective for treating spasticity in patients recovering from stroke. We report a case exploring the use of radial ESWT (rESWT) combined with physiotherapy in a patient with HSP. PATIENT CONCERNS: A 31-year-old man diagnosed with HSP in his 20s had been receiving physical therapy and orthotics but experienced progressive bilateral lower extremity spasticity, leading to deterioration in gait function and mobility. DIAGNOSES: Progressive HSP with exacerbated bilateral lower extremity spasticity manifesting as impaired gait efficiency and reduced functional mobility. INTERVENTIONS: The patient was treated with rESWT focusing bilaterally on the calf muscles. OUTCOMES: Posttreatment, the patient's visual analog scale score for ease of walking improved significantly from 40 to 85, reflecting enhanced walking ability. The timed up and go test results improved from 15.08 to 12.59 seconds and 11.51 to 10.43 seconds at comfortable and maximum speeds, respectively. The 10-meter walk test time decreased from 10.48 to 7.24 seconds, and the step count improved from 20 to 14. Despite the modified Ashworth scale scores and dorsiflexion measurements showing minimal changes, no adverse effects were observed. LESSONS: This case report provides preliminary evidence that rESWT combined with physical therapy may improve gait disturbances, as well as the ease of walking and ambulatory ability, associated with spasticity in HSP. However, due to the limitations of a single-case study and the potential influence of confounding factors, further research - including randomized, placebo-controlled trials - is necessary to confirm its efficacy and determine optimal treatment parameters.2025年08月, Medicine, 104(32) (32), e41921, 英語, 国際誌研究論文(学術雑誌)
- Evidence regarding the effectiveness of rehabilitation treatments in patients with bone metastases remains limited. This study evaluated the implementation and effectiveness of rehabilitation in patients with bone metastases who did not undergo surgery. This retrospective study included 200 patients with nonsurgically treated bone metastases at our institution. The patients were categorized into a rehabilitation group (R group, n = 61) and a non-rehabilitation group (N group, n = 139). Over the course of one month, we compared activities of daily living (ADL), assessed using the Barthel Index (BI), quality of life (QOL), measured using the EuroQoL-5 Dimension (EQ-5D), and demographic and clinical characteristics. Propensity score matching was conducted to minimize selection bias. After matching, 31 patients in each group were included in the analysis. No statistically significant differences were observed in baseline BI and EQ-5D scores between the two groups. In the R group, BI improved significantly from 80 (interquartile range [IQR]: 60-100) to 90 (IQR: 70-100), and EQ-5D improved from 0.444 (IQR: 0.282-0.608) to 0.608 (IQR: 0.533-0.768). In contrast, no improvements were observed in either score in the N group. Chemotherapy was identified as a significant factor associated with improvements in BI (odds ratio 4.03) and EQ-5D (odds ratio 5.29). Rehabilitation may be a valuable treatment option for nonsurgically treated patients with bone metastases, warranting further validation in prospective studies.2025年08月, Journal of bone oncology, 53, 100703 - 100703, 英語, 国際誌研究論文(学術雑誌)
- Background: Locomotive syndrome (LS), a condition characterized by impaired mobility due to locomotive organ dysfunction, is highly prevalent among patients with cancer. The phase angle (PhA), measured via bioelectrical impedance analysis (BIA), reflects cellular health and nutritional status. This study aimed to investigate the association between LS and the PhA in patients with cancer. Methods: This cross-sectional study included hospitalized patients who underwent cancer treatment. The assessed variables included age, sex, body mass index (BMI), gait speed, grip strength, PhA, and the outcomes of LS risk assessment using the stand-up test, two-step test, and the 25-Geriatric Locomotive Function Scale (GLFS25). Results: A total of 190 patients (57 females, 133 males; mean age, 62.6 ± 17.2 years) were analyzed. The PhA was significantly negatively correlated with the LS stage (rs = -0.507, p < 0.001). Similarly, a significant negative correlation was observed between the PhA and each LS risk test, namely, the stand-up test, two-step test, and GLFS25. Furthermore, the PhA was identified as an independent and significant factor associated with LS progression (odds ratio, 0.361; 95% confidence interval, 0.221-0.588; p < 0.001). More effective and rapid than completing the full range of LS risk tests, measuring the PhA represents a convenient and practical tool for the early screening of mobility decline. Conclusions: The PhA is a simple and effective parameter for assessing mobility decline in patients with cancer. It is a potential clinical indicator for initiating rehabilitation interventions aimed at preventing the onset and progression of LS.2025年06月, Journal of clinical medicine, 14(11) (11), 英語, 国際誌研究論文(学術雑誌)
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S236 - S236, 日本語求められる専門医像とは?-各プログラムの実践から学ぶ- 神戸大学リハビリテーション科 先進的医療教育とつながりを重視したプログラムの実践
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S66 - S66, 日本語人工足関節全置換術後患者における歩容特性と術後疼痛の関連 動作センサーを用いた解析
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S167 - S167, 日本語歩行不能な神経筋疾患児と健常児の,生体電気インピーダンス分析法を用いた全身及び四肢筋量・位相角の検討
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S169 - S169, 日本語Klippel-Trenaunay-Weber症候群に対するリハビリテーション診療の経験
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S191 - S191, 日本語消化器がん患者における術前後でのがんとロコモティブシンドローム 食道がんと胃・大腸がんの比較,検討
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S324 - S324, 日本語好酸球性多発血管炎性肉芽腫症の歩行障害に対するリハビリテーション治療と装具療法の有用性
- (公社)日本リハビリテーション医学会, 2025年04月, The Japanese Journal of Rehabilitation Medicine, 62(特別号) (特別号), S424 - S424, 日本語小児神経筋疾患児における生体電気インピーダンス分析法を用いた下肢筋量と位相角の検討
- The use of asfotase alfa, a bone-targeted recombinant alkaline phosphatase (ALP) enzyme, for the treatment of adult-onset hypophosphatasia (HPP) remains controversial, particularly in patients without evident bone abnormalities. We report the case of a 41-year-old woman with a history of Graves' disease, who presented with progressive joint pain and severe fatigue. Despite the absence of bone lesions, the patient was diagnosed with HPP based on persistently low alkaline phosphatase levels, family history, and a novel heterozygous ALPL variant (p.Ala205Thr). Functional analysis revealed a dominant-negative effect for this variant. Her symptoms significantly interfered with her daily activities owing to uncontrolled pain and loss of motor function and were so exacerbated that high doses of acetaminophen and NSAIDs were ineffective. Treatment with asfotase alfa was initiated based on multidisciplinary team consensus. Within 3 months of treatment initiation, her pain improved significantly, as indicated by reduced scores on the visual analog scale from 6.6 to 0.9, and elimination of the need for analgesics. Additionally, her grip strength increased, and her urinary phosphoethanolamine levels and serum pyridoxal 5'-phosphate/pyridoxal ratio decreased from 90.4 to 57.8 μmol/g·creatinine and from 4.6 to 0.4, respectively. These improvements have been maintained for more than 2 years. This case highlights the potential of asfotase alfa in effectively alleviating symptoms in patients with adult-onset HPP without bone lesions, emphasizing the importance of patient selection and outcome monitoring. We also discuss the key considerations for future treatment, supported by a literature review of asfotase alfa in adult patients with HPP.2025年04月, Endocrine journal, 72(4) (4), 437 - 445, 英語, 国内誌研究論文(学術雑誌)
- Objectives Total ankle arthroplasty (TAA) is increasingly performed to alleviate pain and improve function in patients with end-stage ankle osteoarthritis. This study aimed to evaluate the gait characteristics of patients with TAA using a motion sensor-based system and to investigate the relationship between postoperative pain and gait parameters. Methods This cross-sectional study included patients at least three months post-TAA. The evaluated parameters included sex, age, postoperative period, and the dorsiflexion/plantarflexion range of motion (ROM) of the ankle. Gait analysis was performed using a six-axis inertial sensor attached to both shoes to measure stride speed, heel-strike angle, toe-off angle (TOA), pronation angle, foot progression angle, vertical height, swing width, and stride length normalized to height. Pain was assessed using the Self-Administered Foot Evaluation Questionnaire (SAFE-Q). Comparisons were made between the surgical and contralateral sides, and the correlations between pain scores and measured angles were examined. Results Thirty-eight patients (mean age: 76 ± 5 years) were evaluated. The surgical side demonstrated significantly lower TOA (48.9° vs. 59.0°) and plantarflexion ROM (35.5° vs. 49.6°) compared with the contralateral side (p < 0.001). Although the pain scores showed no correlation with ROM, TOA on the surgical side showed a positive correlation with pain scores (r = 0.379, p < 0.05). Conclusions The surgical side exhibited reduced plantarflexion ROM and smaller TOA compared with the contralateral side. Additionally, greater postoperative pain was associated with lower TOA on the surgical side. Therefore, motion sensor-based gait analysis can be a valuable tool for tailoring rehabilitation strategies and improving outcomes following TAA.2025年02月, Cureus, 17(2) (2), e78392, 英語, 国際誌研究論文(学術雑誌)
- Japanese Association of Rehabilitation Medicine, 2025年, Progress in Rehabilitation Medicine, 10, n/a - n/a研究論文(学術雑誌)
- Objectives For patients with brain disorders, regaining the ability to drive is crucial to their reintegration into society. Despite the existence of numerous assessment methods for determining the ability to resume driving, the most effective approach remains unclear. This study evaluated patients with brain disorders who had received support for driving resumption. We examined the factors influencing the acquisition of driving ability in this specific population. Methods This retrospective observational study was conducted from July 2019 to March 2022. Initially, a desk-based assessment was conducted using neuropsychological tests. Successful candidates subsequently underwent an on-road assessment at an affiliated driving school. Patients who passed both assessments were granted permission to resume driving. The participants were categorized into pass and fail groups based on their assessments, and a comparative analysis was conducted. Age, sex, type of brain disorder, functional independence measures (FIMs), assessments of higher cognitive skills, and physical function test results were evaluated. Results Forty-five patients (average age: 62±13 years) underwent evaluation. Logistic regression analysis for the desk-based assessment identified the Rey-Osterrieth complex figure test (ROCFT) (three-minute delayed recall) as the most influential factor (cutoff value: 21.5 points; sensitivity: 65%; specificity, 72.7%). In the on-road assessment, the 10-m walking test was significantly faster in the passing group than in the failing group (p<0.005). Conclusions We demonstrated that the ROCFT (three-minute delayed recall) was the most effective neuropsychological assessment tool for evaluating driving resumption. The assessment of walking speed may also be able to predict the resumption of driving in patients with brain disorders.2024年07月, Cureus, 16(7) (7), e65304, 英語, 国際誌研究論文(学術雑誌)
- Background and Objectives: Changes in activities of daily living (ADL) and quality of life (QOL) of patients with bone metastasis who underwent surgical treatment through Bone Metastasis Cancer Boards (BMCBs), a recent multidisciplinary approach for managing bone metastases, have been reported; however, no reports exist on patients who undergo conservative treatment. In this study, we aimed to evaluate these patients' ADL and QOL and examine the factors influencing changes in these parameters. Materials and Methods: We retrospectively reviewed 200 patients with bone metastases who underwent conservative therapy through BMCBs between 2013 and 2021. A reassessment was conducted within 2-8 weeks after the initial assessment. Patients' background and changes in performance status (PS), Barthel Index (BI), EuroQol five-dimension (EQ-5D) scores, and Numerical Rating Scale (NRS) scores were initially assessed. Furthermore, we categorized patients into two groups based on improvements or deteriorations in ADL and QOL and performed comparative analyses. Results: Significant improvements in EQ-5D (0.57 ± 0.02 versus [vs.] 0.64 ± 0.02), NRS max (5.21 ± 0.24 vs. 3.56 ± 0.21), and NRS average (2.98 ± 0.18 vs. 1.85 ± 0.13) scores were observed between the initial assessment and reassessment (all p < 0.001). PS (1.84 ± 0.08 vs. 1.72 ± 0.08) and BI (83.15 ± 1.68 vs. 84.42 ± 1.73) also showed improvements (p = 0.06, and 0.054, respectively). In addition, spinal cord paralysis (odds ratio [OR]: 3.69, p = 0.049; OR: 8.42, p < 0.001), chemotherapy (OR: 0.43, p = 0.02; OR: 0.25, p = 0.007), and NRS average scores (OR: 0.38, p = 0.02; OR: 0.14, p < 0.001) were independent factors associated with ADL and QOL. Conclusions: Patients with bone metastases who underwent conservative treatment through BMCBs exhibited an increase in QOL without a decline in ADL. The presence of spinal cord paralysis, absence of chemotherapy, and poor pain control were associated with a higher risk of deterioration in ADL and QOL.2024年05月, Medicina (Kaunas, Lithuania), 60(6) (6), 英語, 国際誌研究論文(学術雑誌)
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S449 - S449, 日本語保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S778 - S778, 日本語脊髄性筋萎縮症の側彎と座位機能に関する後方視的観察研究
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S781 - S781, 日本語脊髄性筋萎縮症の運動器合併症の後方視的調査
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S787 - S787, 日本語小児歩行障害に対する装着型サイボーグHALの使用経験
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S1035 - S1035, 日本語がんのリハビリテーション医療におけるPhase Angleとがんロコモティブシンドロームの関連性の検討
- OBJECTIVES: The effectiveness of acute rehabilitation treatment for severe coronavirus disease 2019 (COVID-19) has not yet been established. This study examined the efficacy of treatment provided to patients with severe COVID-19 in an acute care facility. METHODS: A total of 98 patients with severe COVID-19 requiring inpatient management in our intensive care unit (ICU) were included between December 2020 and October 2021. They were divided into two groups: those who received physiotherapy (PT group; n=44) and those who did not receive physiotherapy (non-PT group; n=54). Their backgrounds, clinical characteristics, and activities of daily life (ADL) at discharge were compared to examine factors that influenced the need for physiotherapy (PT). We also evaluated the effect of PT on ADL by comparing the Barthel Index (BI) before PT and at discharge. RESULTS: The PT group patients were significantly older, had longer hospital and ICU stays, and used invasive mechanical ventilators (IMV) more frequently than those in the non-PT group. More patients in the non-PT group were able to walk at discharge than in the PT group. The PT group patients showed significant improvement in BI and ADL at discharge when compared with BI at the start of PT, regardless of whether an IMV was used. CONCLUSIONS: Older patients with severe COVID-19 with prolonged hospitalization or ICU stay or on an IMV are prone to a decline in ADL and may need to be considered for early PT.2024年, Progress in rehabilitation medicine, 9, 20240003 - 20240003, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: In patients vulnerable to skeletal-related events (SREs), a multidisciplinary approach is required to manage risk and determine the best treatment plan. We have used Bone Metastasis Cancer Boards (BMCBs) to deliver multidisciplinary treatments in our hospital since 2013. Here, we report a case in which we used BMCBs to coordinate multidisciplinary treatment for a pregnant patient with breast cancer and multiple bone metastases. CASE: A 41-year-old pregnant woman was admitted to our hospital because low back pain compromised her ability to stand. She was diagnosed with breast cancer-associated multiple bone metastases. Our unit was consulted for rehabilitation therapy, for which we formed a BMCB. The treatment was integrated and performed according to the recommendations of the BMCB. The patient underwent a cesarean section to initiate primary tumor treatment. After evaluating the risk of SREs, we provided her with rehabilitation therapy. Wearing a plastic molded thoracolumbosacral orthosis, she was able to walk with a pick-up walker. The patient continued outpatient chemotherapy and cared for her infant without experiencing any significant adverse events. DISCUSSION: In this case, we formed our BMCB to determine the treatment plan, which we used to support the patient's needs during childbirth and successfully improved her activities of daily living. BMCBs can contribute to preventing SREs and provide effective rehabilitation therapy for patients with bone metastases. We aspire to continually gather experience through our BMCBs and contribute to the establishment of evidence regarding the effectiveness of rehabilitation therapy for patients with bone metastases.2024年, Progress in rehabilitation medicine, 9, 20240032 - 20240032, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: In Japan, there are very few cases of deceased donor liver transplantation (DDLT) and even fewer studies on the effects of DDLT on sarcopenia. This study examined the changes in skeletal muscle mass and quality in DDLT, the factors related to these changes, and survival rates. METHODS: Using computed tomography (CT), we retrospectively measured L3 skeletal muscle index (L3SMI) and intramuscular adipose tissue content (IMAC) at admission, discharge, and 1-year post-DDLT in 23 patients with DDLT from our hospital between 2011 and 2020. We investigated the relationships between changes in L3SMI and IMAC associated with DDLT and between various admission factors and survival. RESULTS: Patients with DDLT showed significant decreases in L3SMI during hospitalization (P < .05). Although L3SMI tended to increase postdischarge, in 11 (73%) cases, it was lower at 1-year post-DDLT than that on admission. Moreover, decreases in L3SMI during hospitalization were correlated to L3SMI on admission (r = 0.475, P < 0.05). Intramuscular adipose tissue content increased from admission to discharge and decreased 1-year post-DDLT. Admission L3SMI and IMAC were not significantly correlated with survival. CONCLUSIONS: This study suggests that the skeletal muscle mass of DDLT patients decreased during hospitalization and showed a slight tendency to improve after discharge, but the decrease tended to be prolonged. In addition, patients with higher skeletal muscle mass at admission tended to lose more skeletal muscle mass during hospitalization. Deceased donor liver transplantation was identified as a potential contributor to improved muscle quality, whereas skeletal muscle mass and quality on admission did not affect post-DDLT survival.2023年09月, Transplantation proceedings, 55(7) (7), 1649 - 1655, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Measurement of skeletal muscle using ultrasonography (US) has received considerable attention as an alternative method of muscle assessment. However, intra- and inter-rater reliability remains controversial. Furthermore, there is no consensus regarding the relationship between muscle assessment using US and muscle mass or physical assessment. We aimed to verify the validity and reliability of muscle measurements using US and its relationships with muscle strength and physical assessment. METHODS: The 22 participants were all healthy men. Quadriceps muscle thickness was measured by US by three different raters. Intraclass correlation coefficient (ICC) was used to assess inter- and intra-rater reliability. The maximum isokinetic strength of the quadriceps and handgrip strength were used as measures of lower and upper muscle strength, respectively. Leg muscle mass was assessed using the leg skeletal muscle index (SMI), measured by body impedance analysis, and calf circumference. RESULTS: The intra-rater reliability was excellent which the ICC(1,1) ranges 0.957-0.993, and ICC(1,3) ranges 0.985-0.998. For inter-rater reliability, the values of 0.904 for ICC(2,1) and 0.966 for ICC(2,3) indicated excellent reliability. Leg SMI was significantly correlated with quadriceps thickness (r=0.36). Maximum isokinetic strength and handgrip strength showed weak but statistically significant correlations with quadriceps thickness (r=0.20, r=0.30, respectively). The correlation between quadriceps thickness and calf circumference was not statistically significant. CONCLUSIONS: Quadriceps muscle assessment using US is a valid and reliable technique for healthy individuals. Quadriceps muscle thickness was significantly positively correlated with upper and lower muscle strength and leg SMI. Muscle thickness assessment could replace full body muscle assessment in clinical settings.2023年, Progress in rehabilitation medicine, 8, 20230008 - 20230008, 英語, 国内誌研究論文(学術雑誌)
- OBJECTIVES: Increased long-term impairment is common among intensive care unit (ICU) survivors. However, predictors of activities of daily living (ADL) in ICU survivors are poorly understood. We aimed to focus on the trajectory of physical function and explore the clinical variables that affect ADL at hospital discharge. METHODS: We enrolled 411 patients admitted to the ICU from April 2018 to October 2020. Physical function was evaluated at ICU admission, ICU discharge, and hospital discharge. We assessed physical function (grip strength, arm and calf circumference, quadriceps thickness, and Barthel index). Patients were assigned to the high or low ADL group based on their Barthel index at discharge. Propensity score matching analysis was performed to minimize selection biases and differences in clinical characteristics. RESULTS: After matching propensity scores, 114 of the 411 patients (aged 65±15 years) were evaluated. The high ADL group showed better physical function at ICU discharge and hospital discharge than the low ADL group. An overall decreasing trend in muscle mass was observed over time; the rates of decline were lower in the high ADL group than in the low ADL group. The cutoff values for relative changes in calf circumference and quadriceps thickness to predict high ADL were -7.89% (sensitivity: 77.8%, specificity: 55.6%) and -28.1% (sensitivity: 81.0%, specificity: 58.8%), respectively. CONCLUSIONS: The relative decreases in calf circumference and quadriceps thickness during hospitalization were lower in patients who maintained their ADL. Assessment of the trajectory of physical function can predict ADL status at hospital discharge among ICU survivors.2023年, Progress in rehabilitation medicine, 8, 20230010 - 20230010, 英語, 国内誌研究論文(学術雑誌)
- Fukuyama-type congenital muscular dystrophy (FCMD) is severe, childhood-onset muscular dystrophy. Recently, our group has discovered a potential treatment using antisense oligonucleotides. Therefore, an effective, reliable, and objective method of assessing muscle is needed. Ultrasound is a minimally invasive tool that can be applied without radiation exposure or pain. Evaluating tissue stiffness by shear wave elastography (SWE) has especially recently attracted attention. Here, we aimed to evaluate SWE value of the upper limb muscles: biceps brachii, triceps brachii, brachioradialis, abductor pollicis brevis, and abductor finger muscle in patients with FCMD. Upper extremity function was evaluated by visual muscle ultrasound analysis (VMUA) and SWE in 13 patients with FCMD and 20 healthy controls. The motor function evaluation tool was used to evaluate motor function, and the correlation with the dynamics of the SWE was determined. VMUA scaled using the Heckmatt scale was higher in patients with FCMD. SWE was also significantly higher and stiffer in the biceps brachii and brachioradialis in patients with FCMD. Furthermore, the severity of FCMD symptoms was correlated with muscle stiffness. We conclude that VMUA and SWE can be useful tools for monitoring muscle atrophy and upper limb function in patients with FCMD.2022年09月, Neuromuscular disorders : NMD, 32(9) (9), 754 - 762, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Advances in cancer treatment have led to an increase in the number of cancer survivors and, likewise, cancer patients in convalescent rehabilitation wards. It is difficult for patients with bone metastases to recover their motor functions and be discharged. However, cancer treatments, such as anti-cancer drug therapy and radiation therapy, are not generally provided in convalescent rehabilitation wards. CASES: This study retrospectively reviewed six cases of bone metastases in our convalescent rehabilitation ward from April 2018 to October 2019. The ages of the patients ranged from 58 to 85 years, and all patients were male. The primary cancers were lung cancer (two cases), renal cancer (one case), esophageal cancer (one case), prostate cancer (one case), and double lung and kidney cancer (one case). Bone metastases were observed in the spine (six cases), pelvis (two cases), and femur (one case). All patients were admitted to our convalescent rehabilitation ward for postoperative management of imminent fracture risk and rehabilitation of pathological fracture or spinal cord compression caused by bone metastasis. None of the patients received treatment for primary cancer or bone metastases during their hospitalization. Two patients had new bone metastases in load-bearing bones. Five patients were transferred to acute care hospitals for the treatment of cancer or infection. DISCUSSION: Before transferring patients with bone metastases to convalescent rehabilitation wards, clinicians should assess the risk of skeletal-related events and the rate of progression of their cancer. Indications for hospitalization should be carefully determined in cooperation with acute care hospitals.2022年, Progress in rehabilitation medicine, 7, 20220022 - 20220022, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Muscle atrophy causes difficulty in resuming daily activities after a fracture. Because transcutaneous carbon dioxide (CO2) application has previously upregulated oxygen pressure in the local tissue, thereby demonstrating its potential in preventing muscle atrophy, here we investigated effects of CO2 application on muscle atrophy after femoral shaft fracture. METHODS: Thirty fracture model rats were produced and randomly divided into a no treatment (control group) and treatment (CO2 group) groups. After treatment, the soleus muscle was dissected at post-fracture days 0, 14, and 21. Evaluations were performed by measuring muscle weight and performing histological examination and gene expression analysis. RESULTS: Muscle weight was significantly higher in the CO2 group than in the control group. Histological analysis revealed that the muscle fiber cross-sectional area was reduced in both groups. Nevertheless, the extent of atrophy was lesser in the CO2 group. Muscle fibers in the control group tended to change into fast muscle fibers. Vascular staining revealed that more capillary vessels surrounded the muscle fibers in the CO2 group than in the control group. Messenger RNA (mRNA) analysis revealed that the CO2 group had a significantly enhanced expression of genes that were related to muscle synthesis. CONCLUSION: Transcutaneous CO2 application may be a novel therapeutic strategy for preventing skeletal muscle atrophy after fracture.2020年03月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(2) (2), 338 - 343, 英語, 国内誌研究論文(学術雑誌)
- UNLABELLED: The acceleration of nerve regeneration remains a clinical challenge. We previously demonstrated that transcutaneous CO2 application using a novel hydrogel increases the oxygen concentration in local tissue via an "artificial Bohr effect" with the potential to prevent muscle atrophy. In this study, we investigated the effect of transcutaneous CO2 administration on limb function after peripheral nerve injury in a rat sciatic nerve injury model. In total, 73 Sprague-Dawley rats were divided into a sham group, a control group (crush injury to sciatic nerve and no treatment) or a CO2 group (crush injury with transcutaneous CO2 application). CO2 was administered percutaneously for 20 min five times per week. Scores for the sciatic function index and pinprick test were significantly higher in the CO2 group than control group. The muscle wet weight ratios of the tibialis anterior and soleus muscles were higher in the CO2 group than control group. Electrophysiological examination showed that the CO2 group had higher compound motor action potential amplitudes and shorter distal motor latency than the control group. Histological examination of the soleus muscle sections at postoperative week 2 showed shorter fiber diameter in the control group than in the CO2 group. The mRNA expression of Atrogin-1 and MuRF-1 was lower, mRNA expression of VEGF and myogenin and MyoD was higher in CO2 group at postoperative week 2 compared to the control group. CLINICAL SIGNIFICANCE: Transcutaneous CO2 application has the therapeutic potential to accelerate the recovery of muscle atrophy in peripheral nerve injury. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1653-1658, 2018.2018年06月, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36(6) (6), 1653 - 1658, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: One of the main complications in patients with muscular dystrophies is cardiac dysfunction. The literature on cardiac involvement in patients with Fukuyama congenital muscular dystrophy (FCMD) is limited. AIM: To compare cardiac involvement between patients with FCMD and Duchenne muscular dystrophy (DMD). METHODS: We compared cardiac involvement between 30 patients with FCMD and 181 patients with DMD using echocardiography and serum biomarkers. All patients were receiving regular checkups at Kobe University Hospital. We used single regression analysis to compare echocardiographic parameters, age, and serum biomarkers. RESULTS: Almost all clinical and echocardiographic parameters were lower in patients with FCMD than DMD. The brain natriuretic peptide concentration in patients with FCMD showed no correlation with age or left ventricular ejection fraction (r=0.231, p=0.22 and r=0.058, p=0.76, respectively). A log-rank test revealed that the risk of left ventricular systolic dysfunction was lower in patients with FCMD than DMD (p=0.046, hazard ratio=0.348). CONCLUSION: The clinical progression of cardiac dysfunction is significantly milder in patients with FCMD than DMD, while skeletal muscle involvement is significantly worse in patients with FCMD. These data suggest that the pathophysiological findings of FCMD can be explained by less severe cardiac dysfunction in FCMD than DMD.2017年11月, Brain & development, 39(10) (10), 861 - 868, 英語, 国際誌研究論文(学術雑誌)
- Adams-Oliver syndrome (AOS, OMIM; 100300) is a rare genetic disease characterized by aplasia cutis congenita, terminal transverse limb defects and cutis marmorata with vascular anomalies such as congenital heart defects. The etiology of this syndrome has remained largely unknown but defective Notch signaling during vascular formation has been suggested. Here we describe a sporadic Japanese newborn case with clinically diagnosed AOS. Trio whole-exome sequencing identified a de novo, novel, heterozygous missense mutation in the Delta-like 4 ligand gene (DLL4 c.572G>A, p.Arg191His) in the patient. DLL4 functions as a requisite ligand for NOTCH1 receptor, which is essential for vascular formation. Amino acid substitution of Arg191 to His was predicted by molecular models to interfere with direct binding between DLL4 and NOTCH1. DLL4 has recently been identified as a causative gene of an autosomal dominant type of AOS with milder symptoms. The case described here showed gradual recovery from skull defects after birth and no psychomotor developmental delay has been observed. This is the second report of an AOS case with DLL4 mutation, and the phenotypic characteristics between the two cases are compared and discussed.2017年09月, Journal of human genetics, 62(9) (9), 851 - 855, 英語, 国際誌研究論文(学術雑誌)
- This corrects the article DOI: 10.1038/jhg.2017.48.2017年09月, Journal of human genetics, 62(9) (9), 869 - 869, 英語, 国際誌
- Carbon dioxide (CO2) therapy can be applied to treat a variety of disorders. We previously found that transcutaneous application of CO2 with a hydrogel decreased the tumor volume of several types of tumors and induced apoptosis via the mitochondrial pathway. However, only one condition of treatment intensity has been tested. For widespread application in clinical antitumor therapy, the conditions must be optimized. In the present study, we investigated the relationship between the duration, frequency, and treatment interval of transcutaneous CO2 application and antitumor effects in murine xenograft models. Murine xenograft models of three types of human tumors (breast cancer, osteosarcoma, and malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma) were used to assess the antitumor effects of transcutaneous CO2 application of varying durations, frequencies, and treatment intervals. In all human tumor xenografts, apoptosis was significantly induced by CO2 treatment for ≥10 min, and a significant decrease in tumor volume was observed with CO2 treatments of >5 min. The effect on tumor volume was not dependent on the frequency of CO2 application, i.e., twice or five times per week. However, treatment using 3- and 4-day intervals was more effective at decreasing tumor volume than treatment using 2- and 5-day intervals. The optimal conditions of transcutaneous CO2 application to obtain the best antitumor effect in various tumors were as follows: greater than 10 min per application, twice per week, with 3- and 4-day intervals, and application to the site of the tumor. The results suggest that this novel transcutaneous CO2 application might be useful to treat primary tumors, while mitigating some side effects, and therefore could be safe for clinical trials.2017年06月, Oncology reports, 37(6) (6), 3688 - 3694, 英語, 国際誌研究論文(学術雑誌)
- Induced Pluripotent-stem-cell Related Genes Contribute to De-differentiation in Oral Squamous Cell Carcinoma.BACKGROUND/AIM: Cancer stem cells are suspected to contribute to malignancy in tumors. Hypoxia affects cell differentiation and induces stem-cell-like characteristics in malignancies. Induced pluripotency was demonstrated in mouse fibroblasts by reprogramming with four transcriptional factors: Oct3/4, Sox2, c-Myc, and Klf4. Conversely, oncogenic transformations frequently express transcriptional factors and Nanog. Therefore, cancer cells present some similarities with induced pluripotent stem (iPS) cells. MATERIALS AND METHODS: We investigated the expression of iPS-related genes in vitro and in clinical samples to identify their relationships with hypoxia and tumorigenesis. RESULTS: Oral squamous cell carcinoma (SCC) cells were used to show that expression levels of Oct3/4, Sox2, and Nanog were significantly increased in hypoxic condition in vitro and in moderately- and poorly-differentiated samples. CONCLUSION: We propose that Oct3/4, Sox2 and Nanog are associated with tumor hypoxia characterized in oral SCC and that these factors may also contribute to the undifferentiated potency observed in oral SCC clinically.2017年03月, Anticancer research, 37(3) (3), 1075 - 1082, 英語, 国際誌研究論文(学術雑誌)
- Survivin is a member of the inhibitor of apoptosis family, which is known to inhibit mitochondrial apoptosis. Survivin is highly expressed in cancers and plays an important role in cancer cell survival, and increased survivin expression is an unfavorable prognostic marker in cancer patients. YM155, a novel small-molecule survivin suppressant, selectively suppresses survivin expression, resulting in the induction of apoptosis in various malignancies. However, the roles of survivin in human malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (MFH/UPS) have not been studied. In the present study, we examined survivin expression in human musculoskeletal tumor tissues, and the effect of survivin inhibition by siRNA or YM155 on apoptotic activity in human MFH/UPS cell lines. In tumor tissues, mRNA expression of survivin was significantly higher in MFH/UPS samples than in benign schwannomas. Moreover, in vitro studies revealed that both survivin siRNA and YM155 suppressed survivin expression and inhibited MFH/UPS cell proliferation in a dose- and a time-dependent manner. Further, the numbers of apoptotic cells significantly increased with YM155 treatment. in vivo, tumor volume in YM155-treated groups was significantly reduced without significant bodyweight loss. Increased apoptotic activity along with decreased survivin expression was also observed in YM155-treated tumors. The findings in this study strongly suggest that survivin suppressants, including YM155, contribute to the suppression of human MFH/UPS cell growth via promoting mitochondrial apoptosis, and that survivin may be a potent therapeutic target for the novel treatment of human MFH/UPS.2015年09月, International journal of oncology, 47(3) (3), 891 - 9, 英語, 国際誌研究論文(学術雑誌)
- Sarcomas are relatively resistant because of hypoxia. We previously demonstrated that the transcutaneous CO(2) therapy reduced hypoxic conditions in human malignant fibrous histiocytoma (MFH). Therefore, we hypothesized that transcutaneous CO(2) therapy could enhance the antitumor effect of radiation therapy in human MFH. Our purpose was to evaluate the effects of transcutaneous CO(2) therapy on the antitumor efficacy of X-ray irradiation using MFH. First, in an in vitro study, we assessed apoptotic activity and reactive oxygen species (ROS) production using flow cytometric and immunoblot analysis at 24 h after X-ray irradiation under three different oxygen conditions (normoxic, reoxygenated and hypoxic). In addition, in the in vivo study, 24 male athymic BALB/c nude mice with MFH tumors that were inoculated in the dorsal subcutaneous area were randomized into four groups: control, CO(2), X-ray irradiation and combination (CO(2) and X-ray irradiation). Treatments were performed twice weekly for 2 weeks, four times in total. Tumor volume was calculated. All tumors were excised and apoptotic activity, ROS production, related proteins and HIF-1α expression were assessed using flow cytometric and immunoblot analysis. The in vitro study revealed that X-ray irradiation induced increased apoptosis and ROS production in MFH cells under normoxic and reoxygenated conditions relative to hypoxic conditions (P<0.01). In the in vivo study, tumor volume in the combination group was reduced to 28, 42 and 47% of that in the control, CO(2), and X-ray groups, respectively (P<0.05). Apoptotic activity and ROS production in the combination group were strongly increased with decreasing HIF-1α expression relative to the control, CO(2) and X-ray groups. The transcutaneous CO(2) system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radio-resistance in human malignancies.2014年08月, International journal of oncology, 45(2) (2), 732 - 8, 英語, 国際誌研究論文(学術雑誌)
- A number of studies have reported that decreased mitochondrial numbers are linked with neoplastic transformation and/or tumor progression, including resistance to apoptosis. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) is a multi-functional transcriptional coactivator that regulates the activities of multiple nuclear receptors and transcriptional factors involved in mitochondrial biogenesis. In this study, we observed that the number of mitochondria in sarcoma tissues, such as osteosarcoma and malignant fibrous histiocytoma, is significantly lower than that in normal muscle tissue or benign tumors, and that increasing the number of mitochondria by PGC-1α overexpression induces mitochondrial apoptosis in human sarcoma cell lines. The findings suggest that decreased mitochondrial numbers may contribute to musculoskeletal tumor progression, and that regulation of mitochondrial numbers by PGC-1α could be a potent therapeutic tool for human malignancies.2014年01月, Scientific reports, 4, 3916 - 3916, 英語, 国際誌研究論文(学術雑誌)
- Decoy receptor 3 (DcR3) is a soluble secreted protein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. DcR3 inhibits the Fas ligand (FasL)/Fas apoptotic pathway by binding to FasL, competitively with Fas receptor. Previous studies have reported that overexpression of DcR3 has been detected in various human malignancies and that DcR3 functions as a 'decoy' for FasL to inhibit FasL-induced apoptosis. In addition, recent studies have revealed that DcR3 has 'non-decoy' functions to promote tumor cell migration and invasion, suggesting that DcR3 may play important roles in tumor progression by decoy and non-decoy functions. We have previously reported that overexpression of DcR3 was observed in human malignant fibrous histiocytoma (MFH), however, the roles of DcR3 in MFH have not been studied. In the present study, to elucidate the roles of DcR3 in tumor progression of MFH, we examined the effects of DcR3 inhibition on cell apoptosis, migration and invasion in human MFH cells. siRNA knockdown of DcR3 enhanced the FasL-induced apoptotic activity and significantly decreased cell migration and invasion with a decrease in the activation of phosphatidylinositol 3 kinase (PI3K)/Akt and matrix metalloproteinase (MMP)-2. The findings in this study strongly suggest that DcR3 plays important roles in tumor progression of human MFH by decoy as well as non-decoy functions and that DcR3 may serve as a potent therapeutic target for human MFH.2013年09月, International journal of oncology, 43(3) (3), 703 - 12, 英語, 国際誌研究論文(学術雑誌)
- Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial improvements in surgery and chemotherapy, metastasis remains a major cause of fatal outcomes, and the molecular mechanisms of metastasis are still poorly understood. Hypoxia, which is common in malignant tumors including osteosarcoma, increases expressions of hypoxia inducible factor (HIF)-1α, matrix metalloproteinase (MMP)-2 and MMP-9, and can induce invasiveness. As we previously showed a novel transcutaneous CO2 application to decrease HIF-1α expression and induce apoptosis in malignant fibrous histiocytoma, we hypothesize that transcutaneous CO2 application could suppress metastatic potential of osteosarcoma by improving hypoxic conditions. Here, we examined the effects of transcutaneous CO2 application on apoptosis, and development of pulmonary metastasis using a highly metastatic osteosarcoma cell line, LM8. Transcutaneous CO2 application significantly decreased tumor growth and pulmonary metastasis in LM8 cells. Apoptotic activity increased, and intratumoral hypoxia was improved with decreased expressions of HIF-1α, MMP-2 and MMP-9, significantly, in the CO2-treated tumors. In conclusion, we found that transcutaneous CO2 application can induce tumor cell apoptosis and might suppress pulmonary metastasis by improvement of hypoxic conditions with decreased expressions of HIF-1α and MMPs in highly metastatic osteosarcoma cell. These findings strongly indicate that this novel transcutaneous CO2 therapy could be a therapeutic breakthrough for osteosarcoma patients.2013年08月, Experimental cell research, 319(13) (13), 1988 - 1997, 英語, 国際誌研究論文(学術雑誌)
- Osteosarcoma (OS) is a primary malignancy of the bone, with a tendency to metastasize early. Despite intensive chemotherapy and surgical resection, more than 30% of patients develop distant metastases, and the prognosis of patients with metastases is essentially poor. Members of the protein kinase D (PKD) family are serine/threonine kinases, and have been studied in various cancers. Among the three different isoforms of this family, PKD1 is one of the best understood for its role in human malignancies; however, its role in musculoskeletal tumors has not been studied. In the present study, we investigated the role of PKD1 in human OS. We first analyzed PKD1 mRNA expression in human musculoskeletal tumor tissue samples by quantitative real-time PCR. PKD1 expression in OS samples was significantly lower than that in benign schwannoma samples, and this was correlated with metastatic potential. In in vitro studies, overexpression of PKD1 by plasmid transfection decreased OS cell invasion, migration and proliferation, and significantly decreased matrix metalloproteinase (MMP)2 mRNA expression. Conversely, siRNA knockdown of PKD1 increased invasion, migration and proliferation of OS cells, and MMP2 expression was markedly increased. Furthermore, overexpression of PKD1 significantly reduced in vivo tumor growth of OS cells. These results demonstrated that low expression of PKD1 may contribute to increased cell invasion, migration and proliferation ability of human OS. Taken together, our findings strongly suggest that PKD1 may negatively regulate the malignant potential of human OS, and may be a therapeutic target for human OS in the clinical setting.2012年06月, International journal of oncology, 40(6) (6), 1839 - 48, 英語, 国際誌研究論文(学術雑誌)
- Mitochondria play an essential role in cellular energy metabolism and apoptosis. Previous studies have demonstrated that decreased mitochondrial biogenesis is associated with cancer progression. In mitochondrial biogenesis, peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) regulates the activities of multiple nuclear receptors and transcription factors involved in mitochondrial proliferation. Previously, we showed that overexpression of PGC-1α leads to mitochondrial proliferation and induces apoptosis in human malignant fibrous histiocytoma (MFH) cells in vitro. We also demonstrated that transcutaneous application of carbon dioxide (CO(2)) to rat skeletal muscle induces PGC-1α expression and causes an increase in mitochondrial proliferation. In this study, we utilized a murine model of human MFH to determine the effect of transcutaneous CO(2) exposure on PGC-1α expression, mitochondrial proliferation and cellular apoptosis. PGC-1α expression was evaluated by quantitative real-time PCR, while mitochondrial proliferation was assessed by immunofluorescence staining and the relative copy number of mitochondrial DNA (mtDNA) was assessed by real-time PCR. Immunofluorescence staining and DNA fragmentation assays were used to examine mitochondrial apoptosis. We also evaluated the expression of mitochondrial apoptosis related proteins, such as caspases, cytochorome c and Bax, by immunoblot analysis. We show that transcutaneous application of CO(2) induces PGC-1α expression, and increases mitochondrial proliferation and apoptosis of tumor cells, significantly reducing tumor volume. Proteins involved in the mitochondrial apoptotic cascade, including caspase 3 and caspase 9, were elevated in CO(2) treated tumors compared to control. We also observed an enrichment of cytochrome c in the cytoplasmic fraction and Bax protein in the mitochondrial fraction of CO(2) treated tumors, highlighting the involvement of mitochondria in apoptosis. These data indicate that transcutaneous application of CO(2) may represent a novel therapeutic tool in the treatment of human MFH.2012年, PloS one, 7(11) (11), e49189, 英語, 国際誌研究論文(学術雑誌)
- (公社)日本義肢装具士協会, 2025年06月, POアカデミージャーナル, 33(1) (1), 28 - 34, 日本語【短下肢装具の新たなアプローチ】当科における急性期・生活期の装具外来の紹介とカーボン製三層式 後方支柱付き短下肢装具ENAPLE AFOの適応について[招待有り]
- (株)日本プランニングセンター, 2025年04月, 難病と在宅ケア, 31(1) (1), 45 - 49, 日本語
- (公社)日本義肢装具士協会, 2025年03月, POアカデミージャーナル, 32(4) (4), 232 - 238, 日本語
- 2025年, 日本がんリハビリテーション研究会プログラム・抄録集, 13thがんのリハビリテーションにおける骨転移リスク管理(多職種連携の観点から)
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)小児神経筋疾患児における生体電気インピーダンス分析法を用いた下肢筋量と位相角の検討
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)人工足関節全置換術後患者における歩容特性と術後疼痛の関連:動作センサーを用いた解析
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)好酸球性多発血管炎性肉芽腫症の歩行障害に対するリハビリテーション治療と装具療法の有用性
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)Klippel-Trenaunay-Weber症候群に対するリハビリテーション診療の経験
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)歩行不能な神経筋疾患児と健常児の,生体電気インピーダンス分析法を用いた全身及び四肢筋量・位相角の検討
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)私のライフワークバランス:小児リハビリテーション科医の挑戦と成長
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)神戸大学リハビリテーション科-先進的医療教育とつながりを重視したプログラムの実践-
- 2025年, Japanese Journal of Rehabilitation Medicine (Web), 62(Supplement) (Supplement)消化器がん患者における術前後でのがんとロコモティブシンドローム:食道がんと胃・大腸がんの比較,検討
- (公社)日本リハビリテーション医学会, 2025年01月, The Japanese Journal of Rehabilitation Medicine, 62(1) (1), 69 - 75, 日本語
- (公社)日本リハビリテーション医学会, 2024年12月, The Japanese Journal of Rehabilitation Medicine, 61(12) (12), 1220 - 1229, 日本語
- 筋ジストロフィー医療研究会, 2024年11月, 筋ジストロフィー医療研究, 11, 35 - 35, 日本語
- (一社)日本義肢装具学会, 2024年10月, 日本義肢装具学会誌, 40(特別) (特別), 184 - 184, 日本語小児下肢機能障害における短下肢装具の使用傾向
- (公社)日本義肢装具士協会, 2024年07月, 日本義肢装具士協会学術大会プログラム・講演集, 30回, 145 - 145, 日本語軽度な下垂足の症状がある患者へ歩行機能改善目的でcarbon shank付きAF0が処方された例
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S195 - S195, 日本語小児希少疾患のリハビリテーション診療
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S449 - S449, 日本語保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S778 - S778, 日本語脊髄性筋萎縮症の側彎と座位機能に関する後方視的観察研究
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S781 - S781, 日本語脊髄性筋萎縮症の運動器合併症の後方視的調査
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S787 - S787, 日本語小児歩行障害に対する装着型サイボーグHALの使用経験
- (公社)日本リハビリテーション医学会, 2024年05月, The Japanese Journal of Rehabilitation Medicine, 61(特別号) (特別号), S1035 - S1035, 日本語がんのリハビリテーション医療におけるPhase Angleとがんロコモティブシンドロームの関連性の検討
- 2024年, 日本がんリハビリテーション研究会プログラム・抄録集, 12th妊娠中の乳がん多発骨転移に対する骨転移キャンサーボードを用いたリハビリテーション診療の1例
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)脊髄性筋萎縮症の運動器合併症の後方視的調査
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)脊髄性筋萎縮症の側弯と座位機能に関する後方視的観察研究
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)小児歩行障害に対する装着型サイボーグHALの使用経験
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)がんのリハビリテーション医療におけるPhase Angleとがんロコモティブシンドロームの関連性の検討
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Autumn) (Autumn)小児悪性骨軟部腫瘍下肢切断術後の化学療法と並行した義足リハビリテーション治療の経験
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Autumn) (Autumn)血液がん患者におけるがんとロコモティブシンドローム:造血幹細胞移植と化学療法の比較,検討
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)保存的治療を受けた骨転移患者のQOLに影響を与える因子の検討
- 2024年, Japanese Journal of Rehabilitation Medicine (Web), 61(Supplement) (Supplement)小児希少疾患のリハビリテーション診療
- (一社)日本理学療法学会連合, 2023年12月, 理学療法学, 50(6) (6), 246 - 250, 日本語
- (一社)日本小児整形外科学会, 2023年11月, 日本小児整形外科学会雑誌, 32(3) (3), S46 - S46, 日本語HPPの多職種連携における小児リハビリテーション科医の果たすべき役割 周産期重症型の診療経験を通して
- (公社)日本リハビリテーション医学会, 2023年10月, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S248 - S248, 日本語急性期リハビリテーション医療における継承と革新 周術期における急性期リハビリテーション医療の継承と革新
- (公社)日本リハビリテーション医学会, 2023年10月, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S355 - S355, 日本語骨転移患者に対するリハビリテーション治療効果 傾向スコアマッチングを用いた検討
- (公社)日本リハビリテーション医学会, 2023年10月, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S357 - S357, 日本語がんリハビリテーション診療におけるPhase Angleの有用性 がんロコモとの関連性の検討
- (公社)日本リハビリテーション医学会, 2023年10月, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S359 - S359, 日本語多発骨転移を伴う肺がん患者がリハビリテーション治療によって自宅退院を達成した一例
- (公社)日本リハビリテーション医学会, 2023年10月, The Japanese Journal of Rehabilitation Medicine, 60(秋季特別号) (秋季特別号), S361 - S361, 日本語精巣がん胸髄転移に対するリハビリテーション治療経験
- (一社)日本義肢装具学会, 2023年09月, 日本義肢装具学会誌, 39(特別) (特別), 176 - 176, 日本語下肢麻痺を有する二分脊椎児へのカーボン製3層式後方支柱付き短下肢装具の使用経験
- (公社)日本リハビリテーション医学会, 2023年05月, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 3 - 1, 日本語色素性乾皮症A群患者の経時的な発達評価による身体認知機能の自然経過
- (公社)日本リハビリテーション医学会, 2023年05月, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 1 - 4, 日本語成人下肢痙縮症例にExtracorporeal Shock Wave Therapy(ESWT)を行った3症例についての検討
- (公社)日本リハビリテーション医学会, 2023年05月, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 1 - 4, 日本語骨転移キャンサーボードが骨転移患者のQOLに及ぼす影響に関する検討
- (公社)日本リハビリテーション医学会, 2023年05月, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 1 - 1, 日本語後期回復期心臓リハビリテーションにおける位相角と運動耐容能の関係性
- (公社)日本リハビリテーション医学会, 2023年05月, The Japanese Journal of Rehabilitation Medicine, 60(特別号) (特別号), 2 - 2, 日本語酵素補充療法中に2度骨折を来した周産期重症型低ホスファターゼ症(hypophosphatasia: HPP)の3歳女児の1例
- 2023年, 日本がんリハビリテーション研究会プログラム・抄録集, 11th骨転移キャンサーボードを用いた骨転移患者のQOL変化の調査
- 2023年, 理学療法学(Web), 50(6) (6)骨転移キャンサーボードの実施により早期の日常生活動作の獲得が可能であった両側大腿骨髄内釘固定術後の一症例
- 2023年, リハビリテーション・ケア合同研究大会, 2023 (Web)骨転移患者に対する多職種によるリハビリテーション診療
- 日本リハビリテーション医学会-近畿地方会, 2023年, リハビリテーション科診療近畿地方会誌, (23) (23), 59 - 63, 日本語
- (一社)日本集中治療医学会, 2022年11月, 日本集中治療医学会雑誌, 29(Suppl.1) (Suppl.1), 495 - 495, 日本語神戸大学医学部附属病院集中治療室における重症COVID-19患者に対するリハビリテーション医療の現状
- (公社)日本リハビリテーション医学会, 2022年10月, The Japanese Journal of Rehabilitation Medicine, 59(10) (10), 1056 - 1060, 日本語
- (公社)日本リハビリテーション医学会, 2022年10月, The Japanese Journal of Rehabilitation Medicine, 59(秋季特別号) (秋季特別号), S419 - S419, 日本語新しいカーボン製後方支柱ENAPLEの兵庫県内における作製状況
- (公社)日本リハビリテーション医学会, 2022年10月, The Japanese Journal of Rehabilitation Medicine, 59(秋季特別号) (秋季特別号), S435 - S435, 日本語過去10年間の神戸大学医学部附属病院のリハビリテーション治療中の転倒・転落インシデントの疫学調査
- (公社)日本リハビリテーション医学会, 2022年10月, The Japanese Journal of Rehabilitation Medicine, 59(秋季特別号) (秋季特別号), S438 - S438, 日本語福山型筋ジストロフィー患者における超音波画像とShear Wave Elastographyを用いた非侵襲的上肢筋評価
- (一社)日本筋学会, 2022年08月, 日本筋学会学術集会プログラム・抄録集, 8回, 120 - 120, 日本語福山型筋ジストロフィーのエラストグラフィーを用いた骨格筋画像評価
- (公社)日本リハビリテーション医学会, 2022年05月, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S269 - S269, 日本語傾向スコアマッチングを用いたICU入室患者の退院時ADLに影響する因子についての検討
- (公社)日本リハビリテーション医学会, 2022年05月, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S274 - S274, 日本語キャンサーボードを用いた骨転移患者診療の経時的変化
- (公社)日本リハビリテーション医学会, 2022年05月, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S654 - S654, 日本語小児がん生存者の復学に向けたリハビリテーション診療
- (公社)日本リハビリテーション医学会, 2022年05月, The Japanese Journal of Rehabilitation Medicine, 59(特別号) (特別号), S663 - S663, 日本語小児下肢機能障害に対するカーボン製短下肢装具ENAPLE-AFOの使用経験
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S356 - S356, 日本語神戸大学医学部附属病院におけるCOVID-19に対するリハビリテーション診療
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S356 - S356, 日本語神戸大学医学部附属病院における第4波期間中の重症COVID-19に対するリハビリテーション治療成績
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S367 - S367, 日本語Lycra Suitの装着が姿勢保持と傍ストーマヘルニア還納に有効であったHirschsprung病児の一例
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S370 - S370, 日本語脳死肝移植が骨格筋量に及ぼす影響についての検討
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S392 - S392, 日本語抗MDA5抗体陽性皮膚筋炎患者に対するリハビリテーション治療の経験
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S403 - S403, 日本語遺伝性痙性対麻痺の患者に対してカーボン製短下肢装具を作成し歩容改善を得た1例
- (公社)日本リハビリテーション医学会, 2021年10月, The Japanese Journal of Rehabilitation Medicine, 58(秋季特別号) (秋季特別号), S405 - S405, 日本語集中治療を受けた患者の退院時ADLに影響を与える因子についての検討
- (一社)日本義肢装具学会, 2021年09月, 日本義肢装具学会誌, 37(特別) (特別), 162 - 162, 日本語側彎症装具とツイスター鋼製ケーブルを連結した1症例
- (公社)日本リハビリテーション医学会, 2021年05月, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 1 - 4, 日本語脳死肝移植の予後に骨格筋量・筋質が与える影響に関する検討
- (公社)日本リハビリテーション医学会, 2021年05月, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 2 - 3, 日本語重症心身障害児における体幹用Dynamic Lycra Orthosisの使用経験
- (公社)日本リハビリテーション医学会, 2021年05月, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 2 - 8, 日本語神経性食欲不振症の患者に入院リハビリテーション治療を施行しADL改善を得た1例
- (公社)日本リハビリテーション医学会, 2021年05月, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 2 - 3, 日本語ワレンベルグ症候群の嚥下障害に対する高解像度マノメトリー(High-Resolution Manometry;HRM)での評価経験
- (公社)日本リハビリテーション医学会, 2021年05月, The Japanese Journal of Rehabilitation Medicine, 58(特別号) (特別号), 3 - 9, 日本語人工膝関節置換術の術後疼痛に影響を与える因子の検討
- 2021年, 福祉心理学研究, 18(1) (1)コロナ渦における社会的養護経験者の実情 COVID-19感染拡大下の社会的養護経験者の実情と必要な支援-当事者の声に基づいた提言-
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S307 - S307, 日本語骨転移キャンサーボードを用いたリハビリテーション治療における患者QOLに影響を与える因子の検討
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S325 - S325, 日本語ZIO STATION2を用いたL3-SMI測定の信頼性評価について
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S338 - S338, 日本語広範な頭蓋骨欠損を認めたアダムス・オリバー症候群に対するリハビリテーション支援
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S342 - S342, 日本語市中回復期病棟において自宅退院に影響する因子についての検討
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S347 - S347, 日本語集中治療後の自宅退院に影響を与える因子についての検討
- (公社)日本リハビリテーション医学会, 2020年11月, The Japanese Journal of Rehabilitation Medicine, 57(秋季特別号) (秋季特別号), S365 - S365, 日本語骨形成不全V型の閉経後女性に対する骨折後リハビリテーション治療の経験
- (一社)日本集中治療医学会, 2020年09月, 日本集中治療医学会雑誌, 27(Suppl.) (Suppl.), 517 - 517, 日本語早期離床・リハビリテーション加算新設に伴う変化について
- (公社)日本リハビリテーション医学会, 2020年07月, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), S419 - S419, 日本語女医歴14年、子育て歴7年 今までやってきたこと、これからやりたいこと
- (公社)日本リハビリテーション医学会, 2020年07月, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 3, 日本語集中治療室に緊急で入室した患者の自宅退院可否についての検討
- (公社)日本リハビリテーション医学会, 2020年07月, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 1 - 5, 日本語入院中のリハビリテーション治療中に転移性骨腫瘍による病的骨折を起こした2例
- (公社)日本リハビリテーション医学会, 2020年07月, The Japanese Journal of Rehabilitation Medicine, 57(特別号) (特別号), 3 - 1, 日本語ベッドサイドにおけるエコーを用いた筋厚測定の信頼性評価について
- (公社)日本リハビリテーション医学会, 2019年10月, The Japanese Journal of Rehabilitation Medicine, 56(秋季特別号) (秋季特別号), S271 - S271, 日本語人工膝関節置換術の術後疼痛に影響を与える因子の検討
- (公社)日本リハビリテーション医学会, 2019年10月, The Japanese Journal of Rehabilitation Medicine, 56(秋季特別号) (秋季特別号), S328 - S328, 日本語超音波画像診断装置を用いた大腿四頭筋厚の測定における検者内および検者間信頼性の検討
- (公社)日本リハビリテーション医学会, 2019年05月, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 9, 日本語がんの骨転移症例に対するリハビリテーション医療の現状と症例検討
- (公社)日本リハビリテーション医学会, 2019年05月, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 1 - 5, 日本語がんの骨転移症例に対するリハビリテーション医療の現状と症例検討
- (公社)日本リハビリテーション医学会, 2019年05月, The Japanese Journal of Rehabilitation Medicine, 56(特別号) (特別号), 3 - 4, 日本語ICU緊急入室患者の退院時ADLに影響を及ぼす因子についての検討
- (公社)日本リハビリテーション医学会, 2018年10月, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S292 - S292, 日本語大学病院ICUにおける早期離床を目指した多職種連携介入の試み
- (公社)日本リハビリテーション医学会, 2018年10月, The Japanese Journal of Rehabilitation Medicine, 55(秋季特別号) (秋季特別号), S346 - S346, 日本語偽性副甲状腺機能低下症に対するリハビリテーション医療の経験
- (公社)日本リハビリテーション医学会, 2018年05月, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 1 - 2, 日本語福山型筋ジストロフィーの筋病変に対する超音波を用いた低侵襲評価
- (公社)日本リハビリテーション医学会, 2018年05月, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 2 - 2, 日本語低TBS(Trabecular Bone Score)値の症例におけるBMD(Bone Mineral Density)の値による特徴
- (公社)日本リハビリテーション医学会, 2018年05月, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 8, 日本語色素性乾皮症A群の発達評価の検討
- (公社)日本リハビリテーション医学会, 2018年05月, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 4, 日本語7p微小重複症候群に対するリハビリテーション医療介入の経験
- (公社)日本リハビリテーション医学会, 2018年05月, The Japanese Journal of Rehabilitation Medicine, 55(特別号) (特別号), 3 - 2, 日本語当院における骨転移リハビリテーションの現状と症例の検討
- (公社)日本義肢装具士協会, 2017年06月, POアカデミージャーナル, 25(Suppl.) (Suppl.), 150 - 151, 日本語小児用股義足製作の一症例(第二報)
- (公社)日本リハビリテーション医学会, 2017年05月, The Japanese Journal of Rehabilitation Medicine, 54(特別号) (特別号), 3 - 6, 日本語脳性麻痺および重症心身障害児におけるDynamic Elastomeric Fabric Orthosisの効果
- 近畿小児整形外科懇話会, 2016年12月, 近畿小児整形外科, 29, 67 - 69, 日本語福山型筋ジストロフィーの脊柱変形に対する半硬性体幹装具治療の小経験
- (公社)日本整形外科学会, 2016年08月, 日本整形外科学会雑誌, 90(8) (8), S1421 - S1421, 日本語
- (公社)日本義肢装具士協会, 2016年06月, POアカデミージャーナル, 24(Suppl.) (Suppl.), 190 - 191, 日本語小児用股義足製作の一症例
- (一社)日本小児放射線学会, 2016年06月, 日本小児放射線学会雑誌, 32(Suppl.) (Suppl.), 29 - 29, 日本語福山型筋ジストロフィー児の包括的全身低線量CT検査の初期経験
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I234 - I234, 日本語福山型筋ジストロフィーの自然歴と運動機能に関する研究
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I237 - I237, 日本語炭酸ガス経皮吸収は、腱炎の治癒を促進する
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I237 - I237, 日本語炭酸ガス経皮吸収は大腿骨骨折モデルの筋萎縮を軽減する
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I238 - I238, 日本語神経圧挫モデルでの神経・筋肉機能回復過程における炭酸ガス経皮吸収の効果について
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I252 - I252, 日本語下咽頭癌でサルコペニアをきたしたポリオ後遺症患者にリハビリテーション介入・長下肢装具導入を行った1例
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I253 - I253, 日本語ポリオ後遺症に対する経皮吸収炭酸ガス治療の有効性および安全性に関する探索的臨床研究
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I410 - I410, 日本語ミトコンドリア生合成の差異が関節リウマチ滑膜細胞に与える影響について
- (公社)日本リハビリテーション医学会, 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I443 - I443, 日本語当院における骨転移キャンサーボード(Bone metastasis board:BMB)の取り組み 3年を経過して
- (公社)日本リハビリテーション医学会, 2015年12月, The Japanese Journal of Rehabilitation Medicine, 52(12) (12), 788 - 788, 日本語
- 日本リハビリテーション医学会-近畿地方会, 2015年12月, リハビリテーション科診療近畿地方会誌, (15) (15), 39 - 44, 日本語
- 日本リハビリテーション医学会-近畿地方会, 2015年12月, リハビリテーション科診療近畿地方会誌, (15) (15), 45 - 52, 日本語
- (公社)日本整形外科学会, 2015年09月, 日本整形外科学会雑誌, 89(8) (8), S1803 - S1803, 日本語
- (公社)日本リハビリテーション医学会, 2015年07月, The Japanese Journal of Rehabilitation Medicine, 52(7) (7), 444 - 444, 日本語
- (公社)日本整形外科学会, 2015年06月, 日本整形外科学会雑誌, 89(6) (6), S1229 - S1229, 日本語
- (公社)日本整形外科学会, 2015年06月, 日本整形外科学会雑誌, 89(6) (6), S1383 - S1383, 日本語
- (公社)日本リハビリテーション医学会, 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S202 - S202, 日本語色素性乾皮症A群(XPA)の発達検査、ADL評価の検討
- (公社)日本リハビリテーション医学会, 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S343 - S343, 日本語薬物による疼痛コントロールが困難であった腎細胞癌脛骨骨転移に対しPTB式免荷装具が有効であった1症例
- (公社)日本リハビリテーション医学会, 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S426 - S426, 日本語炭酸ガス経皮吸収はラット前脛骨筋損傷モデルの治癒を促進する
- (公社)日本リハビリテーション医学会, 2015年02月, The Japanese Journal of Rehabilitation Medicine, 52(2) (2), 146 - 147, 日本語
- 日本リハビリテーション医学会-近畿地方会, 2014年12月, リハビリテーション科診療近畿地方会誌, (14) (14), 30 - 36, 日本語
- (公社)日本整形外科学会, 2014年08月, 日本整形外科学会雑誌, 88(8) (8), S1682 - S1682, 日本語
- (公社)日本整形外科学会, 2014年08月, 日本整形外科学会雑誌, 88(8) (8), S1683 - S1683, 日本語
- (公社)日本整形外科学会, 2014年08月, 日本整形外科学会雑誌, 88(8) (8), S1685 - S1685, 日本語
- (公社)日本整形外科学会, 2014年06月, 日本整形外科学会雑誌, 88(6) (6), S1127 - S1127, 日本語
- (公社)日本リハビリテーション医学会, 2014年05月, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S261 - S261, 日本語
- (公社)日本整形外科学会, 2014年03月, 日本整形外科学会雑誌, 88(2) (2), S365 - S365, 日本語
- (公社)日本整形外科学会, 2014年03月, 日本整形外科学会雑誌, 88(2) (2), S371 - S371, 日本語
- (公社)日本整形外科学会, 2014年03月, 日本整形外科学会雑誌, 88(3) (3), S643 - S643, 日本語
- (公社)日本整形外科学会, 2013年08月, 日本整形外科学会雑誌, 87(8) (8), S1473 - S1473, 日本語
- (公社)日本整形外科学会, 2013年06月, 日本整形外科学会雑誌, 87(6) (6), S1106 - S1106, 日本語
- (公社)日本整形外科学会, 2013年06月, 日本整形外科学会雑誌, 87(6) (6), S1109 - S1109, 日本語
- (公社)日本整形外科学会, 2013年06月, 日本整形外科学会雑誌, 87(6) (6), S1111 - S1111, 日本語
- (公社)日本リハビリテーション医学会, 2013年05月, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361 - S361, 日本語
- (公社)日本リハビリテーション医学会, 2013年05月, The Japanese Journal of Rehabilitation Medicine, 50(Suppl.) (Suppl.), S361 - S361, 日本語
- (公社)日本整形外科学会, 2013年03月, 日本整形外科学会雑誌, 87(3) (3), S720 - S720, 日本語
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, 日本語ミトコンドリア量調節による悪性骨・軟部腫瘍に対する治療の可能性
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1102 - S1102, 日本語炭酸ガス経皮投与療法を用いた骨・軟部肉腫に対する新しい治療法
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1313 - S1313, 日本語
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1380 - S1380, 日本語
- (公社)日本整形外科学会, 2012年06月, 日本整形外科学会雑誌, 86(6) (6), S954 - S954, 日本語
- (公社)日本整形外科学会, 2012年06月, 日本整形外科学会雑誌, 86(6) (6), S969 - S969, 日本語
- (公社)日本整形外科学会, 2012年06月, 日本整形外科学会雑誌, 86(6) (6), S970 - S970, 日本語
- (公社)日本リハビリテーション医学会, 2012年05月, The Japanese Journal of Rehabilitation Medicine, 49(Suppl.) (Suppl.), S268 - S268, 日本語
- (公社)日本整形外科学会, 2012年03月, 日本整形外科学会雑誌, 86(3) (3), S545 - S545, 日本語
- 近畿小児整形外科懇話会, 2012年02月, 近畿小児整形外科, 24, 63 - 64, 日本語乳幼児股関節検診 当院におけるX線検診の検討
- 2012年, 日本小児整形外科学会雑誌, 21(3) (3)化膿性膝関節炎をきたした骨端部Brodie膿瘍の1例
- 日本最小侵襲整形外科学会, 2011年11月, 日本最小侵襲整形外科学会誌, 11(1) (1), 85 - 85, 日本語新しい手技と工夫 Oxford型人工関節単顆置換術に対するfemur first cut法の小経験
- 日本最小侵襲整形外科学会, 2011年11月, 日本最小侵襲整形外科学会誌, 11(1) (1), 87 - 87, 日本語スポーツ外傷・障害に対する最小侵襲治療 膝前十字靱帯解剖学的二重束再建術に対するEZLocフェモラルフィグゼーションデバイスの使用経験
- (株)南江堂, 2011年09月, 整形外科, 62(10) (10), 1109 - 1111, 日本語
- (公社)日本整形外科学会, 2011年08月, 日本整形外科学会雑誌, 85(8) (8), S1320 - S1320, 日本語
- (社医)愛仁会本部, 2011年05月, 愛仁会医学研究誌, 42, 29 - 32, 日本語鎖骨骨幹部骨折の3次元解剖学的プレートの治療成績
- (社医)愛仁会本部, 2011年05月, 愛仁会医学研究誌, 42, 33 - 35, 日本語大腿骨転子部骨折に対する髄内釘治療時の骨頭内固定材料(Femoral Haed Fixating Device;HFD)の至適刺入法
- (株)南江堂, 2011年04月, 別冊整形外科, (59) (59), 29 - 33, 日本語
- (株)南江堂, 2011年04月, 別冊整形外科, (59) (59), 39 - 44, 日本語
- (一社)日本小児整形外科学会, 2011年03月, 日本小児整形外科学会雑誌, 20(1) (1), 31 - 35, 日本語
- (一社)中部日本整形外科災害外科学会, 2011年03月, 中部日本整形外科災害外科学会雑誌, 54(春季学会) (春季学会), 179 - 179, 日本語小児の股関節検診 当院での2009年度検診の報告
- (公社)日本整形外科学会, 2011年02月, 日本整形外科学会雑誌, 85(2) (2), S177 - S177, 日本語
- (一社)日本小児整形外科学会, 2010年10月, 日本小児整形外科学会雑誌, 19(2) (2), 271 - 274, 日本語
- (一社)日本小児整形外科学会, 2010年10月, 日本小児整形外科学会雑誌, 19(2) (2), 394 - 397, 日本語
- (一社)中部日本整形外科災害外科学会, 2010年09月, 中部日本整形外科災害外科学会雑誌, 53(秋季学会) (秋季学会), 143 - 143, 日本語乳幼児の股関節検診における単純X線スクリーニングの有用性と問題点
- 金原出版(株), 2010年07月, 整形・災害外科, 53(8) (8), 1001 - 1005, 日本語
- 近畿小児整形外科懇話会, 2010年06月, 近畿小児整形外科, 22, 87 - 90, 日本語腫瘍性疾患を原因として頸椎回旋位固定(AARF)を呈した2症例
- 近畿小児整形外科懇話会, 2010年06月, 近畿小児整形外科, 22, 21 - 23, 日本語距骨に発症したDysplasia epiphysealis hemimelicaの1例
- (一社)日本足の外科学会, 2010年05月, 日本足の外科学会雑誌, 31(1) (1), S144 - S144, 日本語小児足部疾患治療の新しい展開 先天性垂直距骨治療の変遷と新しい治療法の試み
- (一社)日本小児整形外科学会, 2010年02月, 日本小児整形外科学会雑誌, 19(1) (1), 165 - 165, 日本語
- (一社)中部日本整形外科災害外科学会, 2009年05月, 中部日本整形外科災害外科学会雑誌, 52(3) (3), 794 - 794, 日本語上腕骨近位骨端部に発生したランゲルハンス細胞組織球症の1例
- (一社)日本足の外科学会, 2009年05月, 日本足の外科学会雑誌, 30(1) (1), S133 - S133, 日本語Ponseti法におけるアキレス腱皮下切腱の適応
- (一社)中部日本整形外科災害外科学会, 2009年01月, 中部日本整形外科災害外科学会雑誌, 52(1) (1), 253 - 253, 日本語Pyogenic granulomaの1例
- (株)南江堂, 2008年06月, 整形外科, 59(6) (6), 616 - 619, 日本語
- (一社)中部日本整形外科災害外科学会, 2007年05月, 中部日本整形外科災害外科学会雑誌, 50(3) (3), 542 - 542, 日本語結核性距骨下関節炎の1例
