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音羽 泰則大学院医学系研究科 医科学専攻講師
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■ 論文- Immune-checkpoint blockade (ICB) elicits profound and durable responses in mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) gastrointestinal (GI) cancers, yet most microsatellite-stable (MSS) cancers derive minimal benefit. This gap reflects the limited ability of tumor mutational burden (TMB)-a widely used ICB biomarker-to capture true tumor immunogenicity. Only a small fraction of somatic mutations generates peptides that are processed, presented on HLA molecules, and recognized by T cells, and this pool is further restricted by defects in antigen-presentation pathways, including interferon unresponsiveness, epigenetic repression, and irreversible loss of B2M or HLA class I. These limitations have shifted attention toward neoantigen quality, defined by the presentability, clonal expression, and structural distinctiveness of mutation-derived peptides. Yet even high-quality neoantigens remain functionally irrelevant when presentation is impaired. To integrate these layers, we propose effective immunogenic burden (EIB) as a conceptual framework that describes the state in which tumor mutations generate high-quality neoantigen peptides that are successfully presented on HLA molecules for T-cell recognition. By integrating neoantigen quality and antigen-presentation capacity beyond TMB, EIB provides a clinically interpretable basis for understanding heterogeneous responses to ICB in GI cancers.2026年03月, International journal of clinical oncology, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Esophageal squamous cell carcinoma (ESCC) and hepatic cirrhosis (HC) share major risk factors, including alcohol consumption and smoking. Consequently, patients with HC exhibit an elevated incidence of ESCC. Although HC is widely recognized to contribute to poor prognosis following esophagectomy for ESCC, the underlying mechanisms remain poorly understood. This study aimed to investigate the association between hepatic fibrosis evaluated using the fibrosis-4 (FIB-4) index and postoperative outcomes among patients with ESCC undergoing esophagectomy. METHODS: We retrospectively analyzed 461 patients with ESCC who underwent minimally invasive esophagectomy at Kobe University Hospital. Hepatic fibrosis was evaluated using the FIB-4 index, which estimates liver fibrosis based on routine blood test parameters. Patients were stratified into two groups: fibrosis-positive (FIB-4 > 2.67) and fibrosis-negative (FIB-4 ≤ 2.67). RESULTS: Among patients with cT1 tumors, overall survival (OS) did not differ significantly between the two groups. However, among those with ≥cT2 tumors, the fibrosis-positive group showed significantly worse OS than the fibrosis-negative group (P = 0.0148). Additionally, the fibrosis-positive group had a significantly higher incidence of poor response to preoperative chemotherapy (P = 0.0075). Postoperative serum albumin levels were markedly lower at 3, 6, and 12 months in the fibrosis-positive group (P = 0.015, 0.043, and 0.0066, respectively). While albumin levels recovered to baseline in the fibrosis-negative group within 12 months, no such recovery was observed in the fibrosis-positive group. CONCLUSIONS: Preoperative hepatic fibrosis is associated with poor response to preoperative chemotherapy and prolonged postoperative malnutrition, contributing to poorer long-term survival outcomes among patients with ESCC undergoing minimally invasive esophagectomy.2026年01月, Annals of surgical oncology, 33(1) (1), 444 - 452, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: Previous studies demonstrated the safety of laparoscopic gastrectomy in patients with locally advanced gastric cancer. However, the feasibility of minimally invasive surgery (MIS) following neoadjuvant chemotherapy (NAC) for locally advanced gastric cancer remains unclear. To our knowledge, no previous study has conducted a comprehensive analysis that evaluated NAC and surgical approach simultaneously. This study aimed to assess the feasibility of MIS for locally advanced gastric cancer after NAC using a four-arm comparison. PATIENTS AND METHODS: This study retrospectively analyzed 174 patients who underwent gastrectomy at Kobe University Hospital between January 2011 and July 2024. The patients were categorized into four groups based on NAC and surgical approaches: No NAC/open surgery (n=63), no NAC/MIS (n=49), NAC/open surgery (n=20), and NAC/MIS (n=42). We compared surgical and survival outcomes among the four groups. RESULTS: Patients in the group treated with NAC/MIS experienced less blood loss, fewer transfusions, and a shorter hospital stay. Additionally, compared with the NAC/open (20%) and no NAC/MIS (6.1%) groups, the rate of severe postoperative complications (grade ≥III) was lowest in the group treated with NAC/MIS, with no incidence of pancreatic fistula. The R0 resection rate was highest (97.6%) in the group treated with NAC/MIS. Although 5-year relapse-free survival and overall survival were higher in the group treated with NAC/MIS, the differences were not statistically significant. CONCLUSION: This four-arm study suggests that minimally invasive surgery after NAC for locally advanced gastric cancer may be technically and oncologically safe.2025年12月, Anticancer research, 45(12) (12), 5557 - 5566, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Minimally invasive esophagectomy (MIE) is the standard surgical procedure. Robot-assisted MIE (RAMIE) was developed to overcome the problems associated with conventional MIE. This study investigated whether or not standardizing surgical procedures for RAMIE using soft coagulation scissors and Maryland bipolar forceps could improve short-term outcomes. METHODS: This study included 130 patients who underwent RAMIE. Clinicopathological characteristics and surgical outcomes were compared before and after standardization by two expert surgeons as well as between the standardized and trainee groups. A cumulative sum control chart (CUSUM) was used to evaluate changes in operative time. RESULTS: The console time during the thoracic procedure was shorter in the standardized group than in the pre-standardized group (P < 0.001). The rate of recurrent laryngeal nerve palsy was lower in the standardized group than in the pre-standardized group (P = 0.039). No significant differences were observed between the standardized and trainee groups. In the standardized and trainee groups, CUSUM clearly indicated that the console time peak occurred in the 12th and 16th cases. CONCLUSIONS: Standardization of surgical procedures using an appropriate device for each surgical step could improve surgical outcomes in RAMIE. Furthermore, it may facilitate safer and more efficient surgical training.2025年11月, Surgery today, 英語, 国内誌研究論文(学術雑誌)
- PURPOSE: Esophagectomy and chemoradiotherapy (CRT) are the mainstays of treatment for esophageal squamous cell carcinoma (ESCC). Older patients often do not receive full standard treatment due to physiological limitations. This study aimed to assess the long-term prognosis of surgery or non-surgery treatment for older patients with resectable ESCC. METHODS: This retrospective study included 114 patients who underwent esophagectomy (surgery group) and 65 patients who underwent CRT/radiotherapy (RT) (non-surgery group) at Kobe University Hospital. Propensity score matching was performed to identify matched patients in each tumor stage, including those with cT1N0 ESCC and cT1N-positive or cT2/3N-any ESCC. For cT1N0 ESCC, each group (surgery and non-surgery) had 14 patients. For cT1N-positive or cT2/3N-any ESCC, each group had 34 patients. RESULTS: After propensity score matching, for patients with cT1N0, the overall survival (OS) of the surgery group was significantly better than that of the non-surgery groups (p = 0.016). For cT1N-positive or cT2/3N-any patients, no significant differences were observed in OS between the two groups (p = 0.85). Before matching, in patients with cT1N0 ESCC, those who underwent RT alone had worse OS than patients who underwent surgery or CRT (p = 0.0003). In patients with cT1N-positive or cT2/3N-any ESCC, those who underwent RT alone or surgery alone had worse OS than those who underwent neoadjuvant chemotherapy plus surgery or CRT (p = 0.023). CONCLUSIONS: Patients who could not receive chemotherapy had poor survival. An appropriate treatment strategy should be considered, taking into account their general condition, especially their ability to receive chemotherapy.2025年10月, Esophagus : official journal of the Japan Esophageal Society, 22(4) (4), 546 - 556, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND & AIMS: Oral nutritional supplements (ONS) administered after gastrectomies can prevent postoperative weight loss. However, the amount of additional energy to be added to energy requirements after gastrectomy is unclear. This study aimed to clarify dietary energy intake and its association with weight loss in postgastrectomy patients. METHODS: We performed a single-center, single-arm, open-label, non-randomized clinical trial. Fifty patients with gastric cancer who underwent distal or total gastrectomy were included in this study. Until 3 months postoperatively, the patients continuously consumed ONS and their intake was recorded. Additionally, the patients took photos of their regular diets. Hospital visits were made every 2 weeks to investigate calorie intake (from regular diet plus ONS), physical findings, and nutritional status. The primary endpoint was the percentage of body weight loss (%BWL) at 3 months after gastrectomy. RESULTS: Data were available for 45 patients. %BWL was 7.5 ± 5.1 % at 3 months postoperatively. The group with ONS intake <200 kcal/day tended to show a lower %BWL; however, this was not significant. No correlation was observed between ONS and regular dietary calorie intake. The required calorie intake was 1588 ± 157 kcal/day. Calorie intake from regular diet alone and from regular diet plus ONS were 1330 ± 280 and 1487 ± 300 kcal/day, respectively. The sufficient group, whose total calorie intake met the requirements, had significantly reduced body weight loss, compared with the insufficient group. CONCLUSIONS: After gastrectomy, regular diet alone often fails to meet nutritional requirements, and ONS supplementation may reduce %BWL at 3 months postoperatively by correcting energy deficits. This study was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR; UMIN000047451; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054111).2025年10月, Clinical nutrition ESPEN, 69, 449 - 457, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Several studies have compared robot-assisted minimally invasive esophagectomy (RAMIE) with conventional minimally invasive surgery (C-MIE). However, the anatomical factors that may make certain patients more suitable for RAMIE remains unclear. This study compared the surgical outcomes of RAMIE with those of C-MIE in patients with narrow mediastinum and left-shifted esophagus. METHODS: Between January 2017 and December 2023, 260 patients with esophageal squamous cell carcinoma (ESCC) who underwent MIE (C-MIE or RAMIE) at Kobe University Hospital were included in the study. We developed a new index to assess the narrow mediastinum and left-shifted esophagus at the tracheal bifurcation level using computed tomography imaging. Cox proportional hazards regression analyses were performed to identify the prognostic factors. RESULTS: Patients with a narrow mediastinum and left-shifted esophagus had a higher incidence of recurrent laryngeal nerve (RLN) palsy and fewer lymph nodes dissections than other patients (p = 0.026 and p = 0.051, respectively). In the entire cohort, the operative time in the RAMIE group was longer than that in the C-MIE group (< 0.0001). No significant differences in other variables, including RLN palsy, were observed between the two groups. Among patients with narrow mediastinum and left-shifted esophagus, RAMIE was associated with longer operative time and fewer lymph nodes dissected from the left and right sides of the upper mediastinum compared to C-MIE (p < 0.0001, 0.0001, and 0.0001, respectively). Regarding the RLN palsy, there was no significant difference (p = 0.79). CONCLUSIONS: There are challenges in performing RAMIE in patients with a narrow mediastinal and left-shifted esophagus. Therefore, establishing an effective procedure for these patients is important.2025年07月, Surgical endoscopy, 39(7) (7), 4156 - 4165, 英語, 国際誌研究論文(学術雑誌)
- Outcomes for advanced gastric cancer are improving with multidisciplinary treatment combining surgical resection and perioperative chemotherapy. In Asia, the standard of care for pathological Stage (pStage) II gastric cancer involves tegafur-gimeracil-oteracil potassium for 1 year postoperatively after gastrectomy with D2 lymph node dissection or capecitabine plus oxaliplatin for 6 months postoperatively. For pStage III gastric cancer, a combination of tegafur, gimeracil, and oteracil potassium combined with docetaxel remains the standard postoperative treatment. However, perioperative chemotherapy combined with surgery is being developed to further improve outcomes, similar to approaches in Europe. In addition, the perioperative use of molecularly targeted agents, such as trastuzumab, and immune checkpoint inhibitors, such as pembrolizumab, is expected to improve outcomes. Furthermore, improved chemotherapy outcomes have increased opportunities for surgical intervention in Stage IV gastric cancer, which was previously not indicated for surgery. In this article, we reviewed multidisciplinary treatments for Stage II-IV gastric cancer, combining surgery and chemotherapy.2025年07月, International journal of clinical oncology, 30(7) (7), 1268 - 1275, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Overlap anastomosis is widely used in gastrointestinal reconstruction during minimally invasive gastrectomy. The entry hole of the anastomosis is typically closed with hand-sewn sutures because of concerns about stenosis. This study aimed to compare the efficacy of linear stapler (LS) closure with that of hand-sewn closure of the entry hole in overlap anastomosis. METHODS: We included 172 patients who underwent overlap anastomosis during laparoscopic or robot-assisted total gastrectomy (TG, Roux-en-Y) or distal gastrectomy (DG, Roux-en-Y/Billroth II) between February 2020 and September 2024. The patients were divided into two groups based on the method of entry hole closure: the suturing group (S group) and the LS group. Surgical outcomes were retrospectively analyzed. RESULTS: There were no significant differences in patient characteristics or tumor staging between the two groups. TG was performed in 46 and 17 patients in the S and LS groups, respectively, whereas DG was performed in 41 and 68 patients in the S and LS groups, respectively. In TG patients, there was no significant difference in operative time, but the esophageal-jejunal overlap anastomosis time was significantly shorter in the LS group (38.3 vs. 20.5 min, P < 0.001). The incidence of postoperative complications was similar in both groups, and no cases of stenosis were observed in the LS group. In DG patients, the operative time and gastric-jejunal overlap anastomosis time were significantly shorter in the LS group (294 min vs. 253 min, P = 0.002; 28.5 vs. 9.0 min, P < 0.001). The length of postoperative hospital stay was significantly shorter in the LS group (13 vs. 11 days, P = 0.01). CONCLUSION: Using an LS to close the entry hole in an overlapping anastomosis during minimally invasive gastrectomy can reduce the anastomosis time and may be a safe option without increasing the risk of stenosis.2025年05月, Surgical endoscopy, 39(5) (5), 3346 - 3353, 英語, 国際誌研究論文(学術雑誌)
- Hypoxic tumor microenvironments pose a significant challenge in cancer treatment. Hypoxia-activated prodrugs like evofosfamide aim to specifically target and eliminate these resistant cells. However, their effectiveness is often limited by reoxygenation after cell death. We hypothesized that ascorbate's pro-oxidant properties could be harnessed to induce transient hypoxia, enhancing the efficacy of evofosfamide by overcoming reoxygenation. To test this hypothesis, we investigated the sensitivity of MIA Paca-2 and A549 cancer cells to ascorbate in vitro and in vivo. Ascorbate induced a cytotoxic effect at 5 mM that could be alleviated by endogenous administration of catalase, suggesting a role for hydrogen peroxide in its cytotoxic mechanism. In vitro, Seahorse experiments indicated that the generation of hydrogen peroxide consumes oxygen, which is offset at later time points by a reduction in oxygen consumption due to hydrogen peroxide's cytotoxic effect. In vivo, photoacoustic imaging showed pharmacologic ascorbate treatment at sublethal levels triggered a complex, multi-phasic response in tumor oxygenation across both cell lines. Initially, ascorbate generated transient hypoxia within minutes through hydrogen peroxide production, via reactions that consume oxygen. This initial hypoxic phase peaked at around 150 s and then gradually subsided. However, at longer time scales (approximately 300 s) a vasodilation effect triggered by ascorbate resulted in increased blood flow and subsequent reoxygenation. Combining sublethal levels of i. p. Ascorbate with evofosfamide significantly prolonged tumor doubling time in MIA Paca-2 and A549 xenografts compared to either treatment alone. This improvement, however, was only observed in a subpopulation of tumors, highlighting the complexity of the oxygenation response.2024年09月, Free radical biology & medicine, 222, 579 - 587, 英語, 国際誌研究論文(学術雑誌)
- (一社)日本外科学会, 2024年04月, 日本外科学会定期学術集会抄録集, 124回, PS - 3, 日本語胃癌術後の栄養状態に影響を及ぼす因子の検討
- 兵庫県外科医会, 2024年03月, 兵庫県外科医会会誌, 58, 16 - 22, 日本語
- 兵庫県外科医会, 2024年03月, 兵庫県外科医会会誌, 58, 32 - 32, 日本語食道粘膜下腫瘍に対する胸腔鏡内視鏡合同手術(TECS)の経験
- (一社)日本腹部救急医学会, 2024年02月, 日本腹部救急医学会雑誌, 44(2) (2), 456 - 456, 日本語Meckel憩室による絞扼性腸閉塞の一例
- (一社)日本胃癌学会, 2024年02月, 日本胃癌学会総会記事, 96回, 325 - 325, 日本語年齢が術後1年の栄養状態に与える影響についての検討
- (一社)日本内視鏡外科学会, 2023年12月, 日本内視鏡外科学会雑誌, 28(7) (7), 309 - 309, 日本語食道粘膜下腫瘍に対する胸腔鏡内視鏡合同手術(TECS)の経験
- (一社)日本内視鏡外科学会, 2023年12月, 日本内視鏡外科学会雑誌, 28(7) (7), 1215 - 1215, 日本語超音波ガイド下に嵌頓整復後、待機的に腹腔鏡下同時修復術を施行した閉鎖孔・坐骨孔ヘルニア併存の1例
- Abstract Purpose In this study, we compared two triarylmethyl (TAM) spin probes, Ox071 and Ox063 for their efficacy in measuring tissue oxygen levels under hypoxic and normoxic conditions by R2*‐based EPR oximetry. Methods The R2* dependencies on the spin probe concentration and oxygen level were calibrated using deoxygenated 1, 2, 5, and 10 mM standard solutions and 2 mM solutions saturated at 0%, 2%, 5%, 10%, and 21% of oxygen. For the hypoxic model, in vivo imaging of a MIA PaCa‐2 tumor implanted in the hind leg of a mouse was performed on successive days by R2*‐based EPR oximetry using either Ox071 or Ox063. For the normoxic model, renal imaging of healthy athymic mice was performed using both spin probes. The 3D images were reconstructed by single point imaging and multi‐gradient technique was used to determine R2* maps. Results The signal intensities of Ox071 were approximately three times greater than that of Ox063 in the entire partial pressure of oxygen (pO2) range investigated. The histograms of the tumor pO2 images were skewed for both spin probes, and Ox071 showed more frequency counts at pO2 > 32 mm Hg. In the normoxic kidney model, there was a clear delineation between the high pO2 cortex and the low pO2 medulla regions. The histogram of high‐resolution kidney oximetry image using Ox071 was nearly symmetrical and frequency counts were seen up to 55 mm Hg, which were missed in Ox063 imaging. Conclusion As an oximetric probe, Ox071 has clear advantages over Ox063 in terms of sensitivity and the pO2 dynamic range.Wiley, 2023年09月, Magnetic Resonance in Medicine, 91(1) (1), 413 - 423研究論文(学術雑誌)
- Mary Ann Liebert Inc, 2023年09月, Antioxidants & Redox Signaling, 39(7-9) (7-9), 432 - 444研究論文(学術雑誌)
- (一社)日本大腸肛門病学会, 2023年09月, 日本大腸肛門病学会雑誌, 76(9) (9), A310 - A310, 日本語急速に増大した上行結腸未分化癌の1例
- (一社)日本消化器外科学会, 2023年07月, 日本消化器外科学会総会, 78回, S2 - 2, 日本語PNIは高齢者胃癌患者の予後因子である
- Elsevier BV, 2022年08月, Neoplasia, 30, 100793 - 100793研究論文(学術雑誌)
- Georg Thieme Verlag KG, 2022年02月, Endoscopy International Open, 10(02) (02), E226 - E226研究論文(学術雑誌)
- BACKGROUND: Continuing antithrombic therapy (ATT) during surgery increases the risk of bleeding. However, it is difficult to discontinue the ATT in emergency surgery. Therefore, safety of emergency laparoscopic cholecystectomy (LC) for acute cholecystitis (AC) is still unclear. We aimed to clarify the affect of ATT during emergency LC for AC. METHODS: Patients with AC were classified into ATT group (n = 30) and non-ATT group (n = 120). Postoperative outcomes were compared after propensity score matching (n = 22). RESULTS: Higher level of c-reactive protein level and shorter activated partial thromboplastin time (APTT) was observed in ATT group than in non-ATT group after matching. No significant difference was found between other patient characteristics and perioperative results. Blood loss over 100 mL was observed in 8 patients. Multivariate analyze showed that APTT was an independent risk factor for bleeding over 100 mL (P = 0.039), while ACT and APT was not. CONCLUSIONS: Taking ATT does not affect the blood loss or complications during emergency LC for AC. Controlling intraoperative bleeding is essential for a safe postoperative outcome.2022年02月, BMC surgery, 22(1) (1), 42 - 42, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: Obesity is a major technical limiting factor for laparoscopic surgery because abundant visceral fat is known to extend the operation time. However, special hardware is needed to assess it. We hypothesized that the depth from the peritoneum to the bifurcation of the inferior mesenteric artery (IMA) defined as 'peritoneum to IMA distance (PID)' might be a simple predictive factor for extended operation time during laparoscopic colectomy. PATIENTS AND METHODS: One hundred twenty-four patients who were diagnosed with sigmoid or rectosigmoid colon cancer and underwent laparoscopic colectomy were included. The patients were divided into two groups based on the operation time (210 min). The vertical distance from the peritoneum to the bifurcation of the inferior mesenteric artery was defined as PID. The factors eliciting an operation time longer than 210 min were investigated. RESULTS: There was significant difference in sex, BMI, cT, cN, and PID between the Early group (<210 min) and Late group (≥210 min). Less blood loss was observed in the Early group than in the Late group. Multivariate analysis showed that PID was the only independent factor that affected operation time (p<0.001). CONCLUSION: PID predicts the operation time during laparoscopic colectomy for sigmoid or rectosigmoid colon cancer.2022年, Cancer diagnosis & prognosis, 2(2) (2), 240 - 246, 英語, 国際誌研究論文(学術雑誌)
- Abstract Drastic sensitivity enhancement of dynamic nuclear polarization is becoming an increasingly critical methodology to monitor real-time metabolic and physiological information in chemistry, biochemistry, and biomedicine. However, the limited number of available hyperpolarized 13C probes, which can effectively interrogate crucial metabolic activities, remains one of the major bottlenecks in this growing field. Here, we demonstrate [1-13C] N-acetyl cysteine (NAC) as a novel probe for hyperpolarized 13C MRI to monitor glutathione redox chemistry, which plays a central part of metabolic chemistry and strongly influences various therapies. NAC forms a disulfide bond in the presence of reduced glutathione, which generates a spectroscopically detectable product that is separated from the main peak by a 1.5 ppm shift. In vivo hyperpolarized MRI in mice revealed that NAC was broadly distributed throughout the body including the brain. Its biochemical transformation in two human pancreatic tumor cells in vitro and as xenografts differed depending on the individual cellular biochemical profile and microenvironment in vivo. Hyperpolarized NAC can be a promising non-invasive biomarker to monitor in vivo redox status and can be potentially translatable to clinical diagnosis.Springer Science and Business Media LLC, 2021年06月, Scientific Reports, 11(1) (1)研究論文(学術雑誌)
- Abstract Introduction The closure of the appendiceal stump is a crucial part of a laparoscopic appendectomy, and an endoloop or endostapler is generally used. The endoloop can be more cost effective than the endostapler. However, reports have shown that the endoloop has a higher postoperative abdominal abscess rate than the endostapler in complicated appendicitis. At our institution, we perform a purse‐string suture after ligating by endoloop to reduce postoperative abdominal abscess risk. This study aimed to clarify whether this method could reduce the incidence of postoperative abdominal abscess compared with the endostapler. Methods Patients with acute appendicitis were classified into the purse‐string suture group (n = 149) and the endostapler group (n = 82). Postoperative outcomes were compared after propensity score matching (n = 47). Results No significant difference was found between the two groups in terms of the patient characteristics and postoperative complications, including abdominal abscess. However, the purse‐string suture group had more drain placement and a shorter hospital stay than the endostapler group (P = .04 and P = .02, respectively). In patients with complicated appendicitis, there was less drain placement and a shorter hospital stay in the purse‐string suture group than in the endostapler group (P < .01 and P < .01, respectively). This might have reflected the difficulty of the operation. All postoperative abdominal abscesses occurred in complicated appendicitis cases. Conclusions Endoloop with additional purse‐string suture had a lower incidence of abscess than previous reports of using endoloop alone. Moreover, the postoperative abdominal abscess rate is similar between the two closure methods.Wiley, 2021年04月, Asian Journal of Endoscopic Surgery, 14(4) (4), 775 - 781研究論文(学術雑誌)
- Objective Laparoscopic endoscopic cooperative surgery for duodenal tumors (D‐LECS) has been developed to prevent duodenal leakage by reinforcing the endoscopic submucosal dissection site. However, there has been no prospective trial showing the feasibility of D‐LECS. Herein, we conducted a single‐arm confirmatory trial to evaluate the safety of D‐LECS for non‐ampullary superficial duodenal neoplasms. Methods This prospective single‐center single‐arm confirmatory trial analyzed patients with non‐ampullary superficial duodenal neoplasms who underwent D‐LECS. The primary endpoint was the incidence of any postoperative leakage occurring on the duodenal wall within 1 month postoperatively. The planned sample size was 20 patients, considering a threshold of 28% and one‐sided alpha value of 5%. Results Between January 2015 and September 2018, 20 eligible patients were enrolled. Sixteen tumors were located in the second portion, three in the first portion, and one in the third portion of the duodenal region. The median operative time was 225 (134–361) min and the median blood loss was 0 (0–150) mL. Curative resection (R0) with negative margins was achieved in 19 cases. One case of postoperative leakage and one case of bleeding of grade 2 according to the Clavien–Dindo classification were observed in this series. The median duration of postoperative hospital stay was 9 (5–12) days. No local recurrence was observed in any patient during the median follow‐up of 15.0 (12.0–38.0) months. Conclusions This trial confirmed the safety and feasibility of D‐LECS for non‐ampullary superficial duodenal neoplasms with respect to the low incidence of postoperative duodenal leakage.Wiley, 2020年06月, Digestive Endoscopy, 33(3) (3), 373 - 380研究論文(学術雑誌)
- 兵庫県外科医会, 2020年03月, 兵庫県外科医会会誌, 54, 25 - 25, 日本語当院における正中弓状靱帯症候群に対する手術症例の検討
- 兵庫県外科医会, 2020年03月, 兵庫県外科医会会誌, 54, 25 - 26, 日本語
- 臨床症状が強い食道裂孔ヘルニアに対して腹腔鏡下手術を行った3例(88歳女、91歳女、75歳女)の手術術式・成績を報告した。手術は開脚位・5ポートで行い、裂孔部より胸腔内に脱出している臓器を確認した上で脱出臓器を腹腔内に還納し、術後の消化管狭窄を予防するために術中内視鏡を行いながらヘルニア門を縫縮した。その後、裂孔部にメッシュをステープラで固定し、最後に胃底部後壁を横隔膜脚に固定して手術を終了した。3例はいずれも内科的治療に対して難治性であったため、メッシュ固定を含めた腹腔鏡下食道裂孔修復術を行った。術後は3例とも逆流性症状が改善し、術中・術後合併症なく経過した。兵庫県外科医会, 2020年03月, 兵庫県外科医会会誌, 54, 9 - 12, 日本語
- [Adjuvant Chemotherapy for High-Risk Stage Ⅱ Colon Cancer].BACKGROUND: This study was designed to clarify effects of postoperative adjuvant chemotherapy for high-risk Stage Ⅱ colorectal cancer. METHOD: The subjects were 99 patients with high-risk Stage Ⅱcolorectal cancer who underwent surgery at our department from October 2013 to March 2018. Patients were classified into adjuvant chemotherapy group and nonadjuvant chemotherapy group. Overall survival(OS)and recurrence-free survival(RFS)were analyzed between the 2 groups. RESULTS: Thirty six patients(36.4%)underwent adjuvant chemotherapy. Adjuvant chemotherapy group were younger(p<0.010), had a better ASA-PS(p<0.010), good preoperative Hb(p<0.010), and preoperative Alb(p<0.010)compared to non-adjuvant chemotherapy group. There was no difference between the 2 groups in the high-risk factors for recurrence. Most patient had an oral medication as for adjuvant chemotherapy. There was no difference in OS and RFS between the 2 groups. CONCLUSION: Postoperative adjuvant chemotherapy for high-risk Stage Ⅱ colorectal cancer did not significantly improve the OS and RFS. Further study is necessary to asses the suitable regimen and patients eligible for chemotherapy.2019年08月, Gan to kagaku ryoho. Cancer & chemotherapy, 46(8) (8), 1327 - 1329, 日本語, 国内誌研究論文(学術雑誌)
- [Preoperative Chemotherapy with DCF for Advanced Esophageal Cancer].We conducted a retrospective study to evaluate the efficacy and the problem of the neoadjuvant chemotherapy using DCF for cStage Ⅲ/Ⅳ(squamous cell)esophageal cancer. Eleven patients from January 2017 to December 2018 were enrolled into this study. The median age was 67 years old, male/female ratio was 9:2, performance status was 0 in all patients, and UICC cStage Ⅲ/Ⅳa was 7:4. Cycles of chemotherapy was 2 in 1 patients, 3 in 5 patients and additional 2 courses in 1 patient. Four patients switched to FP therapy after a course of DCF. The efficacy of chemotherapy was evaluated by the clinical response rate, average tumor reduction rate, and histological therapeutic effect rate over Grade 2 which was 63.6%, 48.3%, and 40%, respectively. Neutropenia over Grade 3 was observed in all patients and Grade 4 was observed in 6 patients. In conclusion, preoperative chemotherapy with DCF therapy is useful for the treatment of cStage Ⅲ/Ⅳ(squamous cell) esophageal cancer as long as bone marrow suppression is managed.2019年08月, Gan to kagaku ryoho. Cancer & chemotherapy, 46(8) (8), 1337 - 1339, 日本語, 国内誌研究論文(学術雑誌)
- (株)癌と化学療法社, 2019年08月, 癌と化学療法, 46(8) (8), 1327 - 1329, 日本語
- (株)癌と化学療法社, 2019年08月, 癌と化学療法, 46(8) (8), 1337 - 1339, 日本語
- (一社)日本消化器外科学会, 2019年07月, 日本消化器外科学会総会, 74回, P24 - 3, 日本語当院における高齢者胃癌手術成績の検討
- (一社)日本消化器外科学会, 2019年07月, 日本消化器外科学会総会, 74回, P212 - 2, 日本語高齢で抗凝固薬内服中の急性胆嚢炎に対する腹腔鏡下胆嚢摘出術の安全性についての検討
- (一社)日本消化器外科学会, 2019年07月, 日本消化器外科学会総会, 74回, P237 - 3, 日本語門脈輪状膵を伴った膵頭部IPMNに膵頭十二指腸切除術を施行した1例
- (一社)日本消化器外科学会, 2019年07月, 日本消化器外科学会総会, 74回, P148 - 5, 日本語閉塞性大腸癌に対する自己拡張型金属ステントとイレウスチューブの安全性、有用性についての比較検討
- (一社)日本消化器外科学会, 2019年07月, 日本消化器外科学会総会, 74回, P89 - 1, 日本語当院における大腸癌Stage IIの術後補助化学療法の妥当性の検討
- (NPO)日本食道学会, 2019年06月, 日本食道学会学術集会プログラム・抄録集, 73回, 132 - 132, 日本語当院での食道癌手術における再建の工夫 腹腔鏡下胸骨後経路、胃管再建、胃瘻造設術
- (NPO)日本食道学会, 2019年06月, 日本食道学会学術集会プログラム・抄録集, 73回, 279 - 279, 日本語胃管癌に対する胸腔鏡下幽門側胃管切除術の経験
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, RS - 7, 日本語急性胆嚢炎発症後72時間以内の手術加療を推奨する妥当性の検討
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, PS - 3, 日本語高齢者胃癌患者に対してリンパ節郭清範囲が及ぼす影響についての検討
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, PS - 8, 日本語急性虫垂炎に対する腹腔鏡下虫垂切除術での切除方法による合併症発症の比較
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, PS - 3, 日本語当院での高齢者大腸癌手術の短期成績
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, PS - 8, 日本語当院における腹腔鏡下胃全摘術後の吻合についての後方視的検討
- (一社)日本胃癌学会, 2019年02月, 日本胃癌学会総会記事, 91回, 436 - 436, 日本語当院での高齢者胃癌手術の短期成績
- 2019年, International Surgery, 103(11-12) (11-12)研究論文(学術雑誌)
- BACKGROUND/AIM: The benefits of gastrectomy for elderly gastric cancer (GC) patients remain unknown. The aim of this study was to evaluate the validity of gastrectomy. PATIENTS AND METHODS: Patients who had R0 or R1 resection and diagnosed as pathological Stage I-III GC were enrolled in this study. Patients were classified according to age: Elderly group (≥80 years old), non-Elderly group (70-79 years old), Standard group (≤69 years old). RESULTS: As the age raised, the number of comorbidities increased and patients had a worse physical status. Operative procedure and postoperative complications of the Elderly group were similar to that of the non-Elderly group. The overall survival was similar in pathological Stages I and III between the Elderly and non-Elderly groups, while the Stage II Elderly group had shorter overall survival. Also, the Elderly group did not undergo adjuvant chemotherapy compared to other groups. CONCLUSION: Gastrectomy can be performed safely in elderly patients following gastrectomy, survival of elderly patients was similar to non-elderly patients. Therefore, gastrectomy is an acceptable treatment for elderly patients in good condition.2019年, In vivo (Athens, Greece), 33(4) (4), 1307 - 1311, 英語, 国際誌研究論文(学術雑誌)
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS1 - 6, 日本語当院における胃腫瘍に対する腹腔鏡内視鏡合同手術LECS関連手技の経験
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS65 - 5, 日本語治療アプローチの違いによる急性胆嚢炎の術後短期成績の検討
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS113 - 3, 日本語腹腔鏡下胃全摘術の食道空腸吻合に対するOverlap法の導入と手術成績
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS126 - 4, 日本語急性虫垂炎に対する腹腔鏡下虫垂切除術での切除方法による合併症発症の比較
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS152 - 4, 日本語当院におけるロボット支援胃切除術の導入と現状
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS176 - 1, 日本語腹腔鏡下直腸癌手術における大血管損傷に対する縫合止血術
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), DP144 - 3, 日本語直腸脱に対する腹腔鏡下直腸固定術の検討
- Anticancer Research USA Inc., 2018年11月, Anticancer Research, 38(11) (11), 6139 - 6145研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2018年08月, Surgery Today, 49(1) (1), 90 - 95研究論文(学術雑誌)
- Obturator hernia (OH) is a rare cause of bowel obstruction. Although several surgical approaches, including the laparoscopic approach, have been reported to date, a standard approach for treating OH has not been established. A 101-year-old woman who presented with constipation and vomiting was admitted to our hospital. CT revealed an incarcerated small bowel within the left obturator foramen, and a diagnosis of left-sided incarcerated OH with small bowel ileus was made. With the patient under general anesthesia, exploratory laparoscopy was performed; we identified an OH with an incarcerated small bowel, which was judged viable after hernia reduction. We repaired the hernia using an anterior preperitoneal approach under laparoscopic assistance and placed a prosthetic mesh over the obturator foramen. The patient recovered with no postoperative complications and was discharged on postoperative day 4. A hybrid laparoscopic and anterior preperitoneal approach is safe and effective for treating an incarcerated OH in an elderly patient.2018年08月, Asian journal of endoscopic surgery, 11(3) (3), 277 - 279, 英語, 国内誌研究論文(学術雑誌)
- International Institute of Anticancer Research, 2018年04月, Anticancer Research, 38(4) (4), 2363 - 2368, 英語研究論文(学術雑誌)
- Abstract Background and study aims Endoscopic submucosal dissection (ESD) for duodenal tumors results in a high delayed perforation rate due to the thinness of the duodenal wall. In most cases with perforation after duodenal ESD, additional surgery is needed due to severe peritonitis. A newly developed procedure, laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS), may help to avoid perforation after ESD. In our institution, patients with superficial non-ampullary duodenal epithelial tumors (SNADET) smaller than 50 mm which could not have en-bloc resection by endoscopic mucosal resection were treated with D-LECS. After a laparoscopic exposure of anterior duodenal wall of second portion, ESD was performed. Laparoscopic suturing from the serosal side of ESD site was performed for reinforcement. There were neither postoperative leakage nor other complications. Therefore, D-LECS can be performed safely and prevent perforation after ESD for SNADET. D-LECS could be selected as a treatment for SNADET which can be cured by ESD.Georg Thieme Verlag KG, 2017年11月, Endoscopy International Open, 05(11) (11), E1153 - E1158研究論文(学術雑誌)
- (一社)日本消化器外科学会, 2017年10月, 日本消化器外科学会雑誌, 50(Suppl.2) (Suppl.2), 318 - 318, 日本語十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討
- (一社)日本消化器外科学会, 2017年10月, 日本消化器外科学会雑誌, 50(Suppl.2) (Suppl.2), 318 - 318, 日本語十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討
- Oxford University Press (OUP), 2017年08月, Diseases of the Esophagus, 30(12) (12), 1 - 5研究論文(学術雑誌)
- (一社)日本消化器外科学会, 2017年07月, 日本消化器外科学会総会, 72回, PM17 - 4, 日本語食道癌cStageII/IIIで術前補助化学療法を施行した症例におけるCRP/Albの有用性
- (NPO)日本食道学会, 2017年06月, 日本食道学会学術集会プログラム・抄録集, 71回, P8 - 6, 日本語食道癌同時性重複癌症例に対する同時手術治療症例の検討
- (一社)日本外科学会, 2017年04月, 日本外科学会定期学術集会抄録集, 117回, PS - 3, 日本語食道胃接合部癌Siewert II型に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と逆流防止を意識した偽His角・fornix形成を伴う食道胃管吻合法
- (一社)日本外科学会, 2017年04月, 日本外科学会定期学術集会抄録集, 117回, PS - 7, 日本語Stage IV胃癌に対するConversion surgeryの適応
- (一社)日本胃癌学会, 2017年03月, 日本胃癌学会総会記事, 89回, 339 - 339, 英語StageIV胃癌に対する化学療法後の外科切除の意義(The significance of surgery following chemotherapy for stage IV gastric cancer)
- (一社)日本胃癌学会, 2017年03月, 日本胃癌学会総会記事, 89回, 485 - 485, 英語門脈腫瘍栓を伴う残胃癌に対し、術前化学療法後に残胃全摘術を施行した一例(Gastrectomy after chemotherapy for remnant gastric cancer with portal vein tumor thrombus)
- 日本臨床外科学会, 2016年10月, 日本臨床外科学会雑誌, 77(増刊) (増刊), 564 - 564, 日本語腹腔鏡下鼠径ヘルニア修復術(TEP法)における術中腹膜損傷症例の検討
- Springer Science and Business Media LLC, 2016年09月, Surgical Case Reports, 2(1) (1)研究論文(学術雑誌)
- (NPO)日本食道学会, 2016年07月, 日本食道学会学術集会プログラム・抄録集, 70回, 85 - 85, 日本語合併症低減と根治性を目指した胸腔鏡下食道切除術の現況
- (一社)日本消化器外科学会, 2016年07月, 日本消化器外科学会総会, 71回, P1 - 3, 日本語噴門側胃切除術における偽His角・Fornix形成を行った食道胃管Overlap吻合法の有用性
- (一社)日本消化器外科学会, 2016年07月, 日本消化器外科学会総会, 71回, PD1 - 7, 日本語胃切除後の食道再建術式 胸壁前経路有茎空腸再建術の有用性
- (一社)日本消化器外科学会, 2016年07月, 日本消化器外科学会総会, 71回, P2 - 9, 日本語進行直腸癌におけるmodified Glasgow Prognostic Scoreを用いた治療効果予測
- Abstract Vascular endothelial growth factor-A is a major player in vascular development and a potent vascular permeability factor under physiological and pathological conditions by binding to a decoy receptor Flt1 and its primary receptor Flk1. In this study, we show that Flt1 heterozygous (Flt1+/−) mouse embryos grow up to adult without life-threatening abnormalities but exhibit a transient embryonic edema around the nuchal and back regions, which is reminiscent of increased nuchal translucency in human fetuses. Vascular permeability is enhanced and an intricate infolding of the plasma membrane and huge vesicle-like structures are seen in Flt1+/− capillary endothelial cells. Flk1 tyrosine phosphorylation is elevated in Flt1+/− embryos, but Flk1 heterozygosity does not suppress embryonic edema caused by Flt1 heterozygosity. When Flt1 mutants are crossed with Aspp1−/− mice which exhibit a transient embryonic edema with delayed formation and dysfunction of lymphatic vessels, only 5.7% of Flt1+/−; Aspp1−/− mice survive, compared to expected ratio (25%). Our results demonstrate that Flt1 heterozygosity causes a transient embryonic edema and can be a risk factor for embryonic lethality in combination with other mutations causing non-lethal vascular phenotype.Springer Science and Business Media LLC, 2016年06月, Scientific Reports, 6(1) (1)研究論文(学術雑誌)
- 日本外科系連合学会, 2016年05月, 日本外科系連合学会誌, 41(3) (3), 520 - 520, 日本語Stage IV胃癌に対する外科切除例の予後規定因子に関する検討
- (一社)日本外科学会, 2016年04月, 日本外科学会定期学術集会抄録集, 116回, PS - 6, 日本語切除不能胃癌の集学的治療における外科手術介入の意義
- Elsevier BV, 2016年03月, European Journal of Surgical Oncology (EJSO), 42(3) (3), 407 - 411研究論文(学術雑誌)
- Summary The inflammation-based modified Glasgow prognostic score (mGPS) has been shown to be a prognostic factor for esophageal cancer, but its changes in relation to neoadjuvant chemotherapy (NAC) have never been discussed. The purpose of this study was to evaluate the potential prognostic role of mGPS with regard to NAC. mGPS was evaluated on the basis of admission blood samples taken before chemotherapy and before surgery. Patients with elevated C-reactive protein (CRP) serum levels (>10 mg/L) and hypoalbuminemia (<35 g/L) were allocated a score of 2, patients with elevated CRP serum levels without hypoalbuminemia were allocated a score of 1, and patients with normal CRP serum levels with or without hypoalbuminemia were allocated a score of 0. A total of 100 patients with clinical stage II/III squamous cell esophageal cancer, who underwent NAC and esophagectomy between January 2007 and August 2012, were investigated. From the multivariate analysis, the grade of response to chemotherapy and post-NAC mGPS level was found to be independent prognostic factors. The overall survival rate was significantly higher in the conserved mGPS group than in the worse mGPS group (P = 0.030). Changes in mGPS during chemotherapy affected the prognosis of patients, and post-NAC mGPS is an independent prognostic factor in patients with clinical stage II/III thoracic esophageal squamous cell cancer.Oxford University Press (OUP), 2016年03月, Diseases of the Esophagus, 29(2) (2), 146 - 151研究論文(学術雑誌)
- (一社)日本胃癌学会, 2016年03月, 日本胃癌学会総会記事, 88回, 329 - 329, 英語StageIV胃癌の集学的治療における外科手術の意義(Gastrectomy improves the survival for stageIV gastric cancer)
- Informa UK Limited, 2015年10月, OncoTargets and Therapy, 3169 - 3173研究論文(学術雑誌)
- (一社)日本消化器外科学会, 2015年07月, 日本消化器外科学会総会, 70回, P - 6, 日本語重複癌を有する食道切除術の意義
- (一社)日本消化器外科学会, 2015年07月, 日本消化器外科学会総会, 70回, P - 7, 日本語食道切除後の胸壁前経路有茎空腸再建術の有用性
- (一社)日本外科学会, 2015年04月, 日本外科学会定期学術集会抄録集, 115回, OP - 6, 日本語上部消化管 食道切除後の胸壁前経路有茎空腸再建術の有用性
- (一社)日本外科学会, 2015年04月, 日本外科学会定期学術集会抄録集, 115回, OP - 7, 日本語上部消化管 反回神経麻痺の低減を目指した胸腔鏡下食道切除術の定型化と工夫
- (一社)日本外科学会, 2015年04月, 日本外科学会定期学術集会抄録集, 115回, PD - 4, 日本語骨盤外科における周術期感染対策 栄養・感染症・緩和 直腸癌における化学放射線療法後腹会陰式直腸切断術後の骨盤大網形成術の有用性の検討
- Spandidos Publications, 2015年03月, Oncology Letters, 9(6) (6), 2583 - 2585研究論文(学術雑誌)
- Editorial Committee of Annals of Thoracic and Cardiovascular Surgery, 2015年, Annals of Thoracic and Cardiovascular Surgery, 21(3) (3), 289 - 292研究論文(学術雑誌)
- (一社)日本外科学会, 2014年03月, 日本外科学会雑誌, 115(臨増2) (臨増2), 822 - 822, 日本語
- Baishideng Publishing Group Inc., 2014年, World Journal of Gastroenterology, 20(25) (25), 8317 - 8317研究論文(学術雑誌)
- 2013年10月, 33(10) (10), 4515 - 4519, 英語Thoracoscopic esophagectomy in the prone position for esophageal cancer with right aortic arch: case report研究論文(学術雑誌)
- (一社)日本消化器外科学会, 2013年10月, 日本消化器外科学会雑誌, 46(Suppl.2) (Suppl.2), 222 - 222, 日本語大腸癌内視鏡切除後の追加外科切除例の検討
- (一社)日本消化器外科学会, 2013年10月, 日本消化器外科学会雑誌, 46(Suppl.2) (Suppl.2), 248 - 248, 日本語術前化学放射線療法を行った下部直腸癌の術後補助化学療法の現状と問題点
- (一社)日本消化器外科学会, 2013年10月, 日本消化器外科学会雑誌, 46(Suppl.2) (Suppl.2), 256 - 256, 日本語基礎疾患を有する大腸癌手術症例の検討
- (一社)日本消化器外科学会, 2013年10月, 日本消化器外科学会雑誌, 46(Suppl.2) (Suppl.2), 260 - 260, 日本語残胃癌手術症例の検討
- Springer Science and Business Media LLC, 2013年08月, Surgery Today, 44(11) (11), 2187 - 2190研究論文(学術雑誌)
- (株)協和企画, 2012年10月, 漢方医学, 36(4) (4), 303 - 307, 日本語
- (一社)日本消化器外科学会, 2012年10月, 日本消化器外科学会雑誌, 45(Suppl.2) (Suppl.2), 371 - 371, 日本語肝血管腫として13年間経過観察されていた肝内胆管癌の一切除例
- (一社)日本消化器外科学会, 2012年10月, 日本消化器外科学会雑誌, 45(Suppl.2) (Suppl.2), 376 - 376, 日本語術前MRCP所見で胆嚢捻転症が疑われ胆嚢摘出術を施行した1例
- 日本臨床外科学会, 2012年08月, 日本臨床外科学会雑誌, 73(8) (8), 2021 - 2026, 日本語
- Ovid Technologies (Wolters Kluwer Health), 2012年06月, European Journal of Gastroenterology & Hepatology, 24(6) (6), 727 - 730研究論文(学術雑誌)
- 75歳男。全身衰弱、高度脱水症状で当院救急搬送となり、入院中に下血を認めたため内視鏡検査を施行したところ、5多発胃癌と診断された。上部消化管内視鏡所見では、胃角部大彎後壁寄りおよび胃角部大彎前壁寄りに0-IIa型病変、胃体下部大彎に0-+IIc型病変、胃体上部後壁に1型病変、胃体中部後壁に0-IIa+IIc型病変を認め、全てGroup5であった。以上より、3領域にまたがる5多発胃癌cT3(5)、cN0、cM0、cP0、cH0、cStageIIAと診断され胃全摘術を施行し、リンパ節郭清は術前の全身状態を考慮してD1+とした。切除標本所見では、3領域にまたがる8ヶ所の癌病変と1ヶ所の粘膜下腫瘍を認めた。術後経過は良好で、第22病日に退院となり、現在外来で経過観察中である。(株)南江堂, 2011年12月, 外科, 73(13) (13), 1503 - 1507, 日本語
- 日本臨床外科学会, 2011年01月, 日本臨床外科学会雑誌, 72(1) (1), 203 - 208, 日本語
- 2025年, 日本外科系連合学会誌, 50(2) (2)高度進行胃癌に対する集学的治療戦略
- 2025年, 制癌剤適応研究会プログラム・抄録集, 57th術前化学療法を施行した胸部食道癌における病理学的腫瘍径と予後の関係
- 2025年, 制癌剤適応研究会プログラム・抄録集, 57thSOX+Nivolumab療法により病理学的完全奏効を得られた切除不能進行胃癌の1例
- 2025年, 大腸癌研究会学術集会プログラム・抄録集, 102ndNACRT後直腸癌に対するTaTMEの手術成績
- 2015年, 日本内視鏡外科学会雑誌, 20(7 (CD-ROM)) (7 (CD-ROM))胸腔鏡下食道切除術の治療成績の検討
- 2015年, 日本内視鏡外科学会雑誌, 20(7 (CD-ROM)) (7 (CD-ROM))腹腔鏡補助下・後縦隔経路再建術の手技と工夫
- (一社)日本消化器外科学会, 2013年07月, 日本消化器外科学会総会, 68回, P - 7, 日本語大腸ESD穿孔後の外科的治療の検討
- 第75回日本臨床外科学会総会, 日本語, 藤田保健衛生大学医学部消化器外科, 名古屋, 日本国, 国内会議胸腔鏡併用咽頭喉頭食道全摘術の治療成績口頭発表(一般)
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議Multimodal molecular imaging assessment of tumor microenvironment. Hyaluronan depletion induces tumor reoxygenation and radiosensitization
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議MRI assessment of abscopal effect induced by radiation/immune checkpoint blockade combination therapy
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議Inhibition of GSK3 Activity Detected by Glycogen Synthase Activity from Proton MRS at 3T
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議Family of Novel Hyperpolarized 13C Molecular Imaging Probes Monitors Real-Time Oxidative Stress in Cancer Metabolism
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議EPR and MRI studies of microenvironment in pancreatic cancers. Mechanistic studies of combination therapy with gemcitabine and evofosfamide
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, London, グレートブリテン・北アイルランド連合王国(英国), 国際会議Deuterated trityl spin probe for in vivo pO2 imaging with Time-Domain EPR
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 30st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, Web, 国際会議Multimodal molecular imaging assessment of changes in tumor microenvironment in response to combination of Evofosfamide and GEM
- Joint Annual Meeting ISMRM-ESMRMB & ISMRT 30st Annual Meeting, 英語, International Society for Magnetic Resonance in Medicine, Web, 国際会議Hyaluronan depletion improved intratumor pO2 and sensitized tumor to radiation therapy in pancreatic cancer model mouse
- JDDW2017, 日本語, 杏林大学消化器・一般外科, 福岡, 日本国, 国内会議十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の手術成績の検討ポスター発表
- 第72回日本消化器外科学会総会, 日本語, 金沢大学 消化器・腫瘍・再生外科学, 金沢, 日本国, 国内会議食道癌cStageII/IIIで術前補助化学療法を施行した症例におけるCRP/Albの有用性口頭発表(一般)
- 第71回日本食道学会学術集会, 日本語, 佐久医療センター 内視鏡内科, 軽井沢, 日本国, 国内会議食道癌同時性重複癌症例に対する同時手術治療症例の検討ポスター発表
- 第71回手術手技研究会, 日本語, 藤田保健衛生大学 総合消化器外科, 名古屋, 日本国, 国内会議十二指腸腫瘍に対する腹腔鏡内視鏡合同手術‐当科における手技の工夫と治療成績‐シンポジウム・ワークショップパネル(公募)
- 第117回日本外科学会定期学術集会, 日本語, 群馬大学大学院病態総合外科学, 横浜, 日本国, 国内会議食道胃接合部癌Siewert II型に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と逆流防止を意識した偽His角・fornix形成を伴う食道胃管吻合法ポスター発表
- 第117回日本外科学会定期学術集会, 日本語, 群馬大学大学院病態総合外科学, 横浜, 日本国, 国内会議Stage IV胃癌に対するConversion surgeryの適応ポスター発表
- 第26回兵庫大腸癌治療研究会, 日本語, 奈良県立医科大学第一外科, 神戸, 日本国, 国内会議当院における直腸癌治療の現況口頭発表(一般)
- 第71回日本消化器外科学会総会, 日本語, 徳島大学 消化器・移植外科学, 徳島, 日本国, 国内会議進行直腸癌におけるmodified Glasgow Prognostic Scoreを用いた治療効果予測ポスター発表
- 第71回日本消化器外科学会総会, 日本語, 徳島大学 消化器・移植外科学, 徳島, 日本国, 国内会議胸壁前経路有茎空腸再建術の有用性ポスター発表
- 第71回日本消化器外科学会総会, 日本語, 徳島大学 消化器・移植外科学, 徳島, 日本国, 国内会議噴門側胃切除術における偽His角・Fornix形成を行った食道胃管Overlap吻合法の有用性ポスター発表
- 第70回日本食道学会学術集会, 日本語, 虎の門病院 消化器外科, 東京, 日本国, 国内会議合併症提低減と根治性を目指した胸腔鏡下食道切除術の現況ポスター発表
- 第41回日本外科系連合学会学術集会, 日本語, 兵庫医科大学外科学(肝・胆・膵外科), 大阪, 日本国, 国内会議Stage IV胃癌に対する外科切除例の予後規定因子に関する検討ポスター発表
- 第116回日本外科学会定期学術集会, 日本語, 大阪大学大学院 心臓血管外科, 大阪, 日本国, 国内会議切除不能胃癌の集学的治療における外科手術介入の意義ポスター発表
- 第88回日本胃癌学会学術総会, 日本語, 公益財団法人がん研究会有明病院 消化器外科, 別府, 日本国, 国内会議StageIV胃癌の集学的治療における外科手術の意義ポスター発表
- 第28回日本内視鏡外科学会総会, 日本語, 関西医科大学腎泌尿器外科学講座, 大阪, 日本国, 国内会議腹腔鏡補助下・後縦隔経路再建術の手技と工夫口頭発表(一般)
- 第28回日本内視鏡外科学会総会, 日本語, 関西医科大学腎泌尿器外科学講座, 大阪, 日本国, 国内会議新しい3次元動作解析システムを用いた内視鏡手術の技術分析 - 3Dと2Dモニターにおける鉗子操作の比較検討 -口頭発表(一般)
- 第28回日本内視鏡外科学会総会, 日本語, 関西医科大学腎泌尿器外科学講座, 大阪, 日本国, 国内会議切除不能胃癌に対する外科切除例の予後規定因子に関する検討シンポジウム・ワークショップパネル(公募)
- 第45回胃外科・術後障害研究会, 日本語, 胃外科・術後障害研究会, 名古屋, 日本国, 国内会議Tips of laparoscopic lateral lymph node dissection for rectal cancerシンポジウム・ワークショップパネル(公募)
- The 3rd International Conference of FACO, 英語, 京都大学医学部婦人科学産科学, Kyoto, 日本国, 国際会議Tips of laparoscopic lateral lymph node dissection for rectal cancer.
- 第53回日本癌治療学会学術集会, 日本語, 京都大学大学院医学研究科器官外科学講座 婦人科学産科学, 京都, 日本国, 国内会議Combined thoracoscopic esophagectomy and pedicled jejunal transfer for esophageal cancer口頭発表(一般)
- 第53回日本癌治療学会学術集会, 日本語, 京都大学大学院医学研究科器官外科学講座 婦人科学産科学, 京都, 日本国, 国内会議食道切除後の胸壁前経路有茎空腸再建術の有用性口頭発表(一般)
- 第68回日本胸部外科学会定期学術集会, 日本語, 神戸大学大学院 医学研究科 心臓血管外科学, 神戸, 日本国, 国内会議Safety and Benefit of Curative Surgical Resection for Esophageal Cancer Associated with Multiple Primary Cancersシンポジウム・ワークショップパネル(公募)
- 7TH JAPANESE-MONGOLIAN SYMPOSIUM-2015, 英語, モンゴル国, 国際会議Lyphadenectomy along the Left Recurrent Laryngeal Nerve during Prone Esophagectomy for Esophageal Cancerシンポジウム・ワークショップパネル(公募)
- 第28回近畿内視鏡外科研究会, 日本語, 近畿内視鏡外科研究会事務局, 和歌山, 日本国, 国内会議腹臥位食道癌手術におけるエネルギーデバイスの使い分けとコツシンポジウム・ワークショップパネル(公募)
- 第115回日本外科学会定期学術集会, 日本語, 名古屋大学大学院 腫瘍外科学, 名古屋, 日本国, 国内会議直腸癌における化学放射線療法後腹会陰式直腸切断術後の骨盤大網形成術の有用性の検討シンポジウム・ワークショップパネル(公募)
- 第27回内視鏡外科学会総会, 日本語, 岩手医科大学外科学講座, 岩手, 日本国, 国内会議食道癌に対する胸腔鏡下手術の長期成績シンポジウム・ワークショップパネル(公募)
- 第68回日本食道学会学術集会, 日本語, がん・感染症センター都立駒込病院 内視鏡, 東京, 日本国, 国内会議食道Liposarcomaの1例口頭発表(一般)
- 第68回日本食道学会学術集会, 日本語, がん・感染症センター都立駒込病院 内視鏡, 東京, 日本国, 国内会議術前補助化学療法を施行した食道癌cStageⅡ/ⅢにおけるmGPSの意義口頭発表(一般)
- 第68回日本食道学会学術集会, 日本語, がん・感染症センター都立駒込病院 内視鏡, 東京, 日本国, 国内会議胸部食道癌に対する胸腔鏡下食道切除術の遠隔治療成績の検討シンポジウム・ワークショップパネル(公募)
- 9th Annual Academic Surgical Congress, 英語, Association for Academic Surgery, San Diego, アメリカ合衆国, 国際会議Modified Glasgow Prognostic Score Predicts Histological Response of Neoadjuvant Chemotherapy in cStage II or III Esophageal Cancer
- 第26回日本内視鏡外科学会, 日本語, 福岡大学医学部消化器外科, 福岡, 日本国, 国内会議腹臥位鏡視下食道切除における術後酸素化能の改善口頭発表(一般)
- 第26回日本内視鏡外科学会, 日本語, 福岡大学医学部消化器外科, 福岡, 日本国, 国内会議腹腔鏡下手術における簡便なセプラフィルム貼付法シンポジウム・ワークショップパネル(公募)
- 第75回日本臨床外科学会総会, 日本語, 藤田保健衛生大学医学部消化器外科, 名古屋, 日本国, 国内会議上気道・上部消化管5重複癌の一例口頭発表(一般)
- 第66回日本胸部外科学会定期学術集会, 日本語, 東北大学加齢医学研究所 呼吸器外科学分野, 仙台, 日本国, 国内会議腹臥位食道切除術と術後肺酸素化に与える影響口頭発表(一般)
- 第11回日本消化器外科学会大会, 日本語, 神戸大学大学院肝胆膵外科学, 東京, 日本国, 国内会議残胃癌手術症例の検討ポスター発表
- 第11回日本消化器外科学会大会, 日本語, 神戸大学大学院肝胆膵外科学, 東京, 日本国, 国内会議術前化学放射線療法を行った下部直腸癌の術後補助化学療法の現状と問題点ポスター発表
- 第11回日本消化器外科学会大会, 日本語, 神戸大学大学院肝胆膵外科学, 東京, 日本国, 国内会議大腸癌内視鏡切除後の追加外科切除例の検討ポスター発表
- 第68回日本消化器外科学会総会, 日本語, 宮崎大学医学部 腫瘍機能制御外科学, 宮崎, 日本国, 国内会議大腸ESD穿孔後の外科的治療の検討口頭発表(一般)
- 21st International Congress of the European Association for Endoscopic Surgery, 英語, Vienna, オーストリア共和国, 国際会議STEP-BY-STEP INTRODUCTION OF REDUCED-PORT LAPAROSCOPIC RIGHT HEMICOLECTOMY-FINAL STAGE-SINGLE INCISION PLUS ONE PUNCTURE LAPAROSCOPIC SURGERY-ポスター発表
- 第38回日本外科系連合学会学術集会, 日本語, 東京女子医科大学東医療センター外科, 東京, 日本国, 国内会議S-1/CDDPによるdown staging後根治切除をし得た切除不能進行胃癌の1例ポスター発表
- 第35回日本癌局所療法研究会, 日本語, 神戸大学大学院医学研究科・肝胆膵外科学分野, 神戸, 日本国, 国内会議大腸癌肝転移に対する切除前化学療法施行の検討口頭発表(一般)
- 第35回日本癌局所療法研究会, 日本語, 神戸大学大学院医学研究科・肝胆膵外科学分野, 神戸, 日本国, 国内会議食道癌術前補助化学療法におけるmGPSの意義口頭発表(一般)
- 第67回手術手技研究会, 日本語, 札幌医科大学消化器・総合、乳腺・内分泌外科学講, 札幌, 日本国, 国内会議直腸低位前方切除術においてda Vinci surgical systemを用いたsingle stapling techniqueによる吻合シンポジウム・ワークショップパネル(公募)
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議肺転移における骨髄由来抑制細胞(MDSC)の役割についてポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議大腸癌肝転移症例における、化学療法後の肝切除術の有用性ポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議超高齢者胃癌の外科治療の問題点と可能性ポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議腹会陰式直腸切断術に対する腹腔鏡下大網形成術の有用性/直腸癌の術前化学放射線療法後の合併症対策としてポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議食道切除後の胸壁前経路有茎空腸再建術の有用性ポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議食道癌手術治療における静脈血栓塞栓症予防対策の確立ポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議食道癌cStageⅡ/Ⅲで術前補助化学療法を施行した症例におけるModified Glasgow Prognostic Score(mGPS)の有用性ポスター発表
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議簡便性と安全性を追求した腹腔鏡下直腸切除術-当科での工夫と定型化への試み-シンポジウム・ワークショップパネル(公募)
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議腹臥位胸腔鏡下食道切除術におけるトラブルシューティングシンポジウム・ワークショップパネル(公募)
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議食道癌に対する腹腔鏡補助下胃管再建術の治療成績シンポジウム・ワークショップパネル(公募)
- 第113回日本外科学会, 日本語, 九州大学大学院消化器・総合外科(第二外科), 福岡, 日本国, 国内会議腹腔鏡下横行結腸癌手術におけるリンパ節郭清の工夫シンポジウム・ワークショップパネル(公募)
- THE 21ST ANNUAL MEETING OF THE ASIAN SOCIETY FOR CARDIOVASCULAR AND THORACIC SURGERY, 英語, Kobe, 日本国, 国際会議PRONE THORACOSCOPIC ESOPHAGECTOMY AND IMPROVEMENT OF POSTOPERATIVE PULMONARY OXYGENATION口頭発表(一般)
- 第49回日本腹部救急医学会総会, 日本語, 九州大学大学院医学研究院 先端医療医学講座 災害・救急医学分野, 福岡, 日本国, 国内会議腹腔鏡下回盲部切除術にて治療できた腸腰筋膿瘍を形成した虫垂炎の一例口頭発表(一般)
- 第49回日本腹部救急医学会総会, 日本語, 九州大学大学院医学研究院 先端医療医学講座 災害・救急医学分野, 福岡, 日本国, 国内会議食道穿孔に対する胸腔鏡下食道切除術シンポジウム・ワークショップパネル(公募)
- 第85回日本胃癌学会, 日本語, 大阪市立大学大学院医学研究科腫瘍外科学, 大阪, 日本国, 国内会議胃GISTに対する単孔式腹腔鏡下手術シンポジウム・ワークショップパネル(公募)
- 第85回日本胃癌学会, 日本語, 大阪市立大学大学院腫瘍外科, 大阪, 日本国, 国内会議胸腔鏡下食道癌手術後胃管癌の2切除例の報告ポスター発表
- 第85回日本胃癌学会, 日本語, 大阪市立大学大学院腫瘍外科, 大阪, 日本国, 国内会議高齢者の早期胃癌に対する腹腔鏡補助下幽門側胃切除術の検討口頭発表(一般)
- 第5回日本ロボット外科学会, 日本語, 藤田医科大学 上部消化管外科, 名古屋, 日本国, 国内会議ロボット支援幽門側胃切除術における3D-HD映像と多関節機能の活用口頭発表(一般)
- 第78回大腸癌研究会, 日本語, 東京女子医科大学第二外科, 東京, 日本国, 国内会議局所進行直腸癌治療と腹会陰式直腸切除術会陰部創管理における大網形成術の有用性ポスター発表
- 第25回日本内視鏡外科学会, 日本語, 東京医療センター, 横浜, 日本国, 国内会議高齢者に対する腹腔鏡補助下幽門側胃切除術の検討口頭発表(一般)
- 第25回日本内視鏡外科学会, 日本語, 東京医療センター, 横浜, 日本国, 国内会議当科における腹腔鏡下側方リンパ節郭清について口頭発表(一般)
- 第25回日本内視鏡外科学会, 日本語, 東京医療センター, 横浜, 日本国, 国内会議腹臥位胸腔鏡下食道切除術における縦隔郭清の工夫と手術成績シンポジウム・ワークショップパネル(公募)
- 第25回日本内視鏡外科学会, 日本語, 東京医療センター, 横浜, 日本国, 国内会議腹臥位食道切除術における術中体位の問題点-神経障害を中心として-シンポジウム・ワークショップパネル(公募)
- 第74回日本臨床外科学会, 日本語, 杏林大学医学部外科学教室, 東京, 日本国, 国内会議当科における食道GISTの治療経験口頭発表(一般)
- 第74回日本臨床外科学会, 日本語, 杏林大学医学部外科学教室, 東京, 日本国, 国内会議胃領域リンパ節に転移を認めた悪性黒色腫胃転移の1切除例口頭発表(一般)
- 第74回日本臨床外科学会, 日本語, 杏林大学医学部外科学教室, 東京, 日本国, 国内会議当科における残胃癌に対する手術成績の検討口頭発表(一般)
- 第74回日本臨床外科学会, 日本語, 杏林大学医学部外科学教室, 東京, 日本国, 国内会議下部消化管穿孔症例におけるincisional SSIの予防に対するJ-VAC Drainage Systemの効果について口頭発表(一般)
- 第23回日本消化器癌発生学会, 日本語, 日本消化器癌発生学会本部事務局, 徳島, 日本国, 国内会議ヒトアロ樹状細胞を用いたCTL誘導の試み口頭発表(一般)
- 第50回日本癌治療学会学術集会, 日本語, 兵庫医科大学外科学上部消化管外科, 横浜, 日本国, 国内会議直腸癌における側方リンパ節に対する術前化学放射線療法の治療効果口頭発表(一般)
- 第50回日本癌治療学会学術集会, 日本語, 兵庫医科大学外科学上部消化管外科, 横浜, 日本国, 国内会議StagelV大腸癌原発巣切除例の検討口頭発表(一般)
- 第25回近畿内視鏡外科研究会, 日本語, 京都, 日本国, 国内会議腹臥位胸腔鏡下食道切除におけるトラブルシューティング口頭発表(一般)
- 第77回大腸癌研究会, 日本語, 国立がん研究センター中央病院 消化管内科, 東京, 日本国, 国内会議進行再発大腸癌化学療法後の外科的局所切除の意義口頭発表(一般)
- 第77回大腸癌研究会, 日本語, 国立がん研究センター中央病院 消化管内科, 東京, 日本国, 国内会議進行再発大腸癌化学療法後の外科的局所切除の意義口頭発表(一般)
- the 20th International Congress of the European Association for Endoscopic Surgery (EAES) in Brussels, 英語, Brussels, ベルギー王国, 国際会議laparoscopic harvest of perineal omentplasty wtih rectal resection for rectal cancer口頭発表(一般)
- 日本学術振興会, 科学研究費助成事業, 若手研究(B), 神戸大学, 2016年04月01日 - 2018年03月31日血管内皮増殖因子受容体の異常による先天性水頭症の発症機序我々は、VEGF-Aの受容体であるFlt1とFlk1のダブルヘテロ欠損(Flt1+/-; Flk1+/-)マウスが、先天性水頭症をきたし2ヶ月齢頃までに致死となることを見出した。ダブルヘテロマウスを解析し、排出経路として硬膜リンパ管と静脈洞が考えられた。Flk1+/-マウスでは、静脈洞周囲のリンパ管内皮細胞数の減少を認めたが、排出機能に異常は認めなかった。Flt1+/-マウスでは脈絡叢の浮腫を認めた。Flt1+/-;Flk1+/-マウスが先天性水頭症を起こす機序として、脈絡叢での脳脊髄液の増加によるもので、、ダブルヘテロとなることで、Flt1の欠損異常がより強く反映されると考えられた。
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2014年04月01日 - 2017年03月31日生理的リンパ管・静脈吻合の形成機構と機能的意義本研究では、生理的リンパ管・静脈吻合の形成機構と機能的意義、ならびに末梢組織中の血管・リンパ管吻合形成による重度浮腫の改善効果とリンパ管形成に果たす役割について解析した。生理的リンパ管・静脈吻合の形成がAspp1によって制御されていること、胎仔の発生と生存維持に必須であること、その異常はリンパ管・血管吻合を非侵襲的に作製しても改善されないことを明らかにした。新規ガイダンス分子Semaphorin 3Gは生理的リンパ管・静脈吻合の形成には不要であるが、Nrp2/PlexinD1受容体複合体を介してリンパ管内皮細胞に反発シグナルを与えて分布を制御することを明らかにした。
