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川合 宏哉大学院医学系研究科 医科学専攻教授
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■ 論文- AIM: Acute coronary syndrome (ACS) and ischemic stroke are major life-threatening conditions caused by atherosclerosis. Although the mechanisms of atherosclerosis appear to be broadly similar across different vascular beds, growing evidence suggests that there are morphological and histological differences between coronary and carotid atherosclerosis. To identify disease-specific therapeutic strategies, we aimed to compare ACS and chronic coronary syndrome (CCS) in coronary artery disease, and symptomatic and asymptomatic carotid artery disease. METHODS: We analyzed our own single-cell RNA sequencing dataset for coronary artery disease (GSE184073) and a publicly available dataset for carotid artery disease (GSE253903). Myeloid cells were extracted from these datasets and comparative analyses were performed using metabolic profiling and an RNA velocity analysis. RESULTS: By integrating multiple velocity-inference approaches, including the original and dynamic RNA velocity models, TFvelo using transcription factor regulatory information, and CellRank, we consistently identified a differentiation trajectory toward interleukin-1B (IL1B)＋ inflammatory macrophages marked by high expression of matrix metalloproteinase 19 (MMP19). This trajectory was accompanied by the activation of the glycolytic and glycosaminoglycan degradation pathways. A similar directional flow toward IL1B＋ inflammatory macrophages was also observed in symptomatic carotid artery plaques. However, unlike coronary lesions, carotid lesions activated the glycolytic pathway in SPP1＋ foamy macrophages expressing MMP19. CONCLUSIONS: Our findings revealed a shared differentiation trajectory into IL1B＋ inflammatory macrophages in carotid and coronary artery diseases, which is associated with plaque vulnerability. Notably, the distinct activation of the glycolytic pathway in a separate macrophage subset suggests that tailored therapeutic strategies may be necessary to effectively address plaque vulnerability in each vascular bed.2026年03月, Journal of atherosclerosis and thrombosis, 英語, 国内誌研究論文（学術雑誌）
- 2026年01月, Circulation reports, 8(1) (1), 58 - 67, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本心血管インターベンション治療学会, 2025年07月, 日本心血管インターベンション治療学会抄録集, 33回, MO50 - 5, 英語Perfusion balloonによる拡張を契機に生じた冠動脈穿孔をダブルガイドテクニックで止血し得た1例(A case of coronary artery perforation caused by perfusion balloon dilation was successfully hemostatically treated using the double-guided technique)
- BACKGROUND: Data on the impact of valve position on clinical outcomes in patients with atrial fibrillation (AF) and bioprosthetic valves (BPVs) are limited. METHODS AND RESULTS: The BPV-AF Registry was a multicenter, prospective, observational study involving 894 patients with BPVs and AF. In this post-hoc substudy, patients were classified according to BPV position: aortic (n=588; 65.8%), mitral (n=195; 21.8%), or both (n=111; 12.4%). The primary outcome was a composite of stroke/systemic embolism, major bleeding, heart failure requiring hospitalization, all-cause death, or BPV reoperation. During a mean follow up of 15.3±4.0 months, the primary outcome occurred in 90 (15.3%) patients (12.7/100 patient-years) in the aortic group, 25 (12.8%; 10.2/100 patient-years) in the mitral group, and 16 (14.4%; 11.8/100 patient-years) in the both-valves group (log-rank P=0.621). The unadjusted and adjusted risks were not significant for the mitral and both-valves groups relative to the aortic group (unadjusted hazard ratio [95% confidence interval] 0.80 [0.52-1.25] and 0.92 [0.54-1.57]; adjusted hazard ratio 0.89 [0.51-1.54] and 1.10 [0.58-2.09], respectively). There was no significant difference in the incidence of stroke/systemic embolism or major bleeding among the 3 groups (log-rank P=0.651 and 0.156, respectively). CONCLUSIONS: In patients with BPVs and AF, the risk for the composite outcome was comparable regardless of the BPV position.2024年11月, Circulation reports, 6(11) (11), 521 - 528, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Current guidelines recommend direct oral anticoagulants (DOACs) and warfarin for patients with atrial fibrillation (AF) who have a bioprosthetic valve (BPV). However, the data related to elderly patients (aged ≥80 years) with BPV replacement and AF are limited. METHODS: This post-hoc subgroup analysis of a BPV-AF Registry enrolled 752 patients with BPV replacement and AF. The primary net outcome was a composite of cardiac death, stroke, systemic embolism, major bleeding, and cardiovascular events. RESULTS: Among 752 patients, 429 (57%) patients were ≥ 80 and 323 (43%) were < 80 years old. The higher risk in patients aged ≥80 than <80 years was significant for the net outcome (hazard ratio [HR], 2.04; 95% confidence interval [CI], 1.31-3.17; P = 0.001). After adjustment for confounders, there was no statistically significant difference between warfarin (reference) and DOAC users in the risk of net outcomes (adjusted HR, 1.26; 95% CI, 0.71-2.24; P = 0.44), stroke and systemic embolism (adjusted HR, 2.01; 95% CI, 0.48-8.38; P = 0.34), and major bleeding (adjusted HR, 0.73; 95% CI, 0.11-4.98; P = 0.75) in patients aged ≥80 years old as well as those aged <80 years. Among 489 warfarin users, the cumulative incidence of net outcomes tended to be higher in patients aged ≥80 than <80 years (12.2% vs. 5.7% at 1 year, log-rank P = 0.002). Among 263 DOAC users, however, it was similar between patients aged ≥80 and < 80 years. CONCLUSIONS: The present study demonstrated that DOAC showed similar efficacy and safety compared with warfarin even in elderly patients aged ≥80 years with BPV replacement and AF.2024年10月, International journal of cardiology, 413, 132375 - 132375, 英語, 国際誌研究論文（学術雑誌）
- UNLABELLED: Polymyositis (PM) and dermatomyositis (DM) are chronic inflammatory muscle disorders characterized by muscle weakness and fatigue. They are histopathologically defined by inflammatory cell infiltrates in the skeletal muscle. In a recent meta-analysis, the incidence of cardiovascular complications in patients with PM/DM ranged from 9 to 72 %, with heart failure being the most commonly reported heart disease. In cases of heart failure accompanied by severe mitral regurgitation that is refractory due to guideline-directed medical therapy, the transcatheter edge-to-edge mitral valve repair (TEER) procedure using the MitraClip (Abbott Vascular, Santa Clara, CA, USA) offers an alternative therapeutic approach. We present a pioneering case report describing the successful application of TEER in a young woman with drug-refractory heart failure due to cardiovascular involvement in PM. LEARNING OBJECTIVE: •In polymyositis (PM)/ dermatomyositis (DM), the most commonly reported clinical heart disorder is heart failure, with some cases attributed to mitral regurgitation.•Patients suffering from systemic inflammatory diseases such as PM/DM often face high surgical risk, and the MitraClip is an effective treatment modality.2024年09月, Journal of cardiology cases, 30(3) (3), 90 - 93, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: There are few studies evaluating the prognostic prediction method in atrial fibrillation (AF) patients after bioprosthetic valve (BPV) replacement. The R2-CHA2DS2-VASc score is increasingly used for the prediction of cardiovascular (CV) events in patients with AF, device implantation, and acute coronary syndrome. We aimed to evaluate the predictive value of the R2-CHA2DS2-VASc score for future CV events in AF patients after BPV replacement. METHODS AND RESULTS: The BPV-AF, an observational, multicenter, prospective registry, enrolled AF patients who underwent BPV replacement. The primary outcome measure was a composite of stroke, systemic embolism, CV events including heart failure requiring hospitalization, and cardiac death. A total of 766 patients was included in the analysis. The mean R2-CHA2DS2-VASc score was 5.7±1.8. Low (scores 0-1), moderate (scores 2-4), and high (scores 5-11) R2-CHA2DS2-VASc score groups consisted of 12 (1.6%), 178 (23.2%), and 576 (75.2%) patients, respectively. The median follow-up period was 491 (interquartile range 393-561) days. Kaplan-Meier analysis showed a higher incidence of the composite CV events in the high R2-CHA2DS2-VASc score group (log rank test; P<0.001). Multivariate Cox proportional hazards regression analysis revealed that the R2-CHA2DS2-VASc score as a continuous variable was an independent predictor of composite CV outcomes (hazard ratio 1.36; 95% confidence interval 1.18-1.55; P<0.001). CONCLUSIONS: The R2-CHA2DS2-VASc score is useful for CV risk stratification in AF patients after BPV replacement.2024年08月, Circulation reports, 6(8) (8), 341 - 348, 英語, 国内誌研究論文（学術雑誌）
- Coronary artery fistula is a rare anomaly, and localized re-entrant atrial tachycardia (AT) in the coronary sinus (CS) has rarely been reported. We report a case in a patient with a left circumflex artery aneurysm associated with the CS fistula who underwent radiofrequency catheter ablation for localized re-entrant AT, which originated from the CS.2024年05月, JACC. Case reports, 29(10) (10), 102333 - 102333, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Acute coronary syndrome (ACS) involves plaque-related thrombosis, causing primary ischemic cardiomyopathy or lethal arrhythmia. We previously demonstrated a unique immune landscape of myeloid cells in the culprit plaques causing ACS by using single-cell RNA sequencing. Here, we aimed to characterize T cells in a single-cell level, assess clonal expansion of T cells, and find a therapeutic target to prevent ACS. METHODS: We obtained the culprit lesion plaques from 4 patients with chronic coronary syndrome (chronic coronary syndrome plaques) and the culprit lesion plaques from 3 patients with ACS (ACS plaques) who were candidates for percutaneous coronary intervention with directional coronary atherectomy. Live CD45+ immune cells were sorted from each pooled plaque samples and applied to the 10× platform for single-cell RNA sequencing analysis. We also extracted RNA from other 3 ACS plaque samples and conducted unbiased TCR (T-cell receptor) repertoire analysis. RESULTS: CD4+ T cells were divided into 5 distinct clusters: effector, naive, cytotoxic, CCR7+ (C-C chemokine receptor type 7) central memory, and FOXP3 (forkhead box P3)+ regulatory CD4+ T cells. The proportion of central memory CD4+ T cells was higher in the ACS plaques. Correspondingly, dendritic cells also tended to express more HLAs (human leukocyte antigens) and costimulatory molecules in the ACS plaques. The velocity analysis suggested the differentiation flow from central memory CD4+ T cells into effector CD4+ T cells and that from naive CD4+ T cells into central memory CD4+ T cells in the ACS plaques, which were not observed in the chronic coronary syndrome plaques. The bulk repertoire analysis revealed clonal expansion of TCRs in each patient with ACS and suggested that several peptides in the ACS plaques work as antigens and induced clonal expansion of CD4+ T cells. CONCLUSIONS: For the first time, we revealed single cell-level characteristics of CD4+ T cells in patients with ACS. CD4+ T cells could be therapeutic targets of ACS. REGISTRATION: URL: https://upload.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000046521; Unique identifier: UMIN000040747.2024年05月, Arteriosclerosis, thrombosis, and vascular biology, 44(5) (5), 1135 - 1143, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: We investigated the efficacy of left ventricular (LV) myocardial damage by native T1mapping obtained with cardiac magnetic resonance (CMR) for patients undergoing transcatheter edge-to-edge repair (TEER).Methods and Results: We studied 40 symptomatic non-ischemic heart failure (HF) patients and ventricular functional mitral regurgitation (VFMR) undergoing TEER. LV myocardial damage was defined as the native T1Z-score, which was converted from native T1values obtained with CMR. The primary endpoint was defined as HF rehospitalization or cardiovascular death over 12 months after TEER. Multivariable Cox proportional hazards analysis showed that the native T1Z-score was the only independent parameter associated with cardiovascular events (hazard ratio 3.40; 95% confidential interval 1.51-7.67), and that patients with native T1Z-scores <2.41 experienced significantly fewer cardiovascular events than those with native T1Z-scores ≥2.41 (P=0.001). Moreover, the combination of a native T1Z-score <2.41 and more severe VFMR (effective regurgitant orifice area [EROA] ≥0.30 cm2) was associated with fewer cardiovascular events than a native T1Z-score ≥2.41 and less severe VFMR (EROA <0.30 cm2; P=0.002). CONCLUSIONS: Assessment of baseline LV myocardial damage based on native T1Z-scores obtained with CMR without gadolinium-based contrast media is a valuable additional parameter for better management of HF patients and VFMR following TEER.2024年03月, Circulation journal : official journal of the Japanese Circulation Society, 88(4) (4), 519 - 527, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Transcatheter aortic valve replacement (TAVR) for severe symptomatic aortic stenosis (AS) does not benefit all patients. We performed a prospective multicenter study to investigate the cost-effectiveness of TAVR in a Japanese cohort. METHODS AND RESULTS: We prospectively enrolled 110 symptomatic patients with severe AS who underwent TAVR from five institutions. The quality of life measurement (QOL) was performed for each patient before and at 6 months after TAVR. Patients without an improvement in QOL at 6 months after TAVR were defined as non-responders. Pre-TAVR higher QOL, higher clinical frailty scale predicted the non-responders. Three models, 1) conservative treatment for all patients strategy, 2) TAVR for all patients strategy, and 3) TAVR for a selected patient strategy who is expected to be a responder, were simulated. Lifetime cost-effectiveness was estimated using incremental cost-effectiveness ratio (ICER) and cost per quality-adjusted life-year (QALY) gained. In comparison to conservative therapy for all patients, ICER was estimated to be 5,765,800 yen/QALY for TAVR for all patients and 2,342,175 yen/QALY for TAVR for selected patient strategy patients, which is less than the commonly accepted ICER threshold of 5,000,000 yen/QALY. CONCLUSIONS: TAVR for selected patient strategy model is more cost-effective than TAVR for all patient strategy without reducing QOL in the Japanese healthcare system. TAVR for selected patient strategy has potential benefit for optimizing the TAVR treatment in patients with high frailty and may direct our resources toward beneficial interventions.2024年03月, Journal of cardiology, 83(3) (3), 169 - 176, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本核医学会, 2024年, 核医学, 61(Suppl.) (Suppl.), S175 - S175, 日本語肺疾患を合併した肺動脈性肺高血圧症の治療効果を換気血流シンチから検討する
- 2024年, Circulation journal : official journal of the Japanese Circulation Society, 88(9) (9), 1598 - 1602, 英語, 国内誌研究論文（学術雑誌）
- 2023年10月, Circulation journal : official journal of the Japanese Circulation Society, 87(11) (11), 1706 - 1706, 英語, 国内誌研究論文（学術雑誌）
- UNLABELLED: Infective endocarditis (IE) is a rare, life-threatening complication of MitraClip (Abbott, Abbott Park, IL, USA) therapy. We report a case of an 84-year-old male who underwent transcatheter edge-to-edge mitral valve (MV) repair using MitraClip (Abbott, Abbott Park, IL, USA) 4 weeks prior for ventricular functional mitral regurgitation (MR) and returned with unstable hemodynamics and high-grade fever. Transthoracic echocardiography (TTE) on emergency admission showed thickening of the anterior mitral leaflet (AML) without apparent MR deterioration. TTE and transesophageal echocardiography (TEE) performed the next day showed severe MR due to rapidly progressing AML degeneration with aneurysmal formation. During the TEE examination, exacerbated heart failure due to severe MR caused cardiogenic shock and subsequent ventricular fibrillation, necessitating emergency extracorporeal cardiopulmonary resuscitation. Considering the positive findings of methicillin-resistant Staphylococcus aureus (MRSA) in blood cultures and degenerative MV findings, MitraClip-related IE was diagnosed; finally, MV replacement was performed. Retrospective consideration suggested that the potential causes of this MitraClip-related IE were valve injuries caused by multiple full-close procedures and insufficient prophylaxis for preoperatively detected MRSA. MitraClip-related IE has destructive characteristics that necessitate surgical intervention despite high risks; therefore, we should prevent procedure-related MV injuries and implement preoperative infection precautions to prevent catastrophic complications, particularly in patients with preoperative nasal MRSA-positive findings. LEARNING OBJECTIVES: MitraClip-related infective endocarditis (IE) is a rare but fatal condition. IE caused by methicillin-resistant Staphylococcus aureus (MRSA), in particular, has an inferior prognosis with high mortality rates due to its destructive nature. Therefore, interventionalists should consider preventive strategies to avoid procedure-related valve injuries and adequately prepare for prophylaxis of patients who are carriers of MRSA to prevent MitraClip-related IE caused by MRSA.2023年06月, Journal of cardiology cases, 27(6) (6), 279 - 282, 英語, 国内誌
- Background: The left atrial volume index (LAVI) is important for predicting thromboembolism in patients with non-valvular atrial fibrillation (AF), but the utility of LAVI for predicting thromboembolism in patients with both bioprosthetic valve replacement and AF remains unclear. Methods and Results: Of 894 patients from a previous multicenter prospective observational registry (BPV-AF Registry), 533 whose LAVI data had been obtained by transthoracic echocardiography were included in this subanalysis. Patients were divided into tertiles (T1-T3) according to LAVI as follows: T1 (n=177), LAVI=21.5-55.3 mL/m2; T2 (n=178), LAVI=55.6-82.1 mL/m2; T3 (n=178), LAVI=82.5-408.0 mL/m2. The primary outcome was defined as either stroke or systemic embolism for a mean (±SD) follow-up period of 15.3±4.2 months. Kaplan-Meier curves indicated that the primary outcome tended to occur more frequently in the group with the larger LAVI (log-rank P=0.098). Comparison of T1 with T2 plus T3 using Kaplan-Meier curves indicated that patients in T1 experienced significantly fewer primary outcomes (log-rank P=0.028). Furthermore, univariate Cox proportional hazard regression showed that 1.3- and 3.3-fold more primary outcomes occurred in T2 and T3, respectively, than in T1. Conclusions: Larger LAVI was associated with stroke or systemic embolism in patients who had undergone bioprosthetic valve replacement and with a definitive diagnosis of AF.2023年05月, Circulation reports, 5(5) (5), 210 - 216, 英語, 国内誌研究論文（学術雑誌）
- 日本心臓核医学会, 2023年05月, 日本心臓核医学会ニュースレター, 25(2) (2), 92 - 92, 日本語運動誘発性冠攣縮性狭心症と考えられた症例
- 日本心臓核医学会, 2023年05月, 日本心臓核医学会ニュースレター, 25(2) (2), 93 - 93, 日本語多枝急性冠症候群の残存虚血をFFR-CTとRIで行った1例
- 日本心臓核医学会, 2023年05月, 日本心臓核医学会ニュースレター, 25(2) (2), 94 - 94, 日本語ガイドラインの変遷のなかで7年の経過で画像診断から治療選択をしえた症例
- 2023年05月, European heart journal. Case reports, 7(5) (5), ytad215, 英語, 国際誌
- (公財)日本心臓財団, 2023年04月, 心臓, 55(4) (4), 446 - 451, 日本語
- 2023年03月, JACC. Cardiovascular interventions, 16(5) (5), 609 - 610, 英語, 国際誌研究論文（学術雑誌）
- 2023年03月, Circulation reports, 5(3) (3), 97 - 98, 英語, 国内誌研究論文（学術雑誌）
- UNLABELLED: Metal allergy is a concern in percutaneous coronary intervention (PCI) with stent implantation because of its potential association with poor cardiovascular outcomes, such as stent thrombosis and recurrent in-stent restenosis requiring revascularization. Although stentless PCI with drug-coated balloon (DCB) angioplasty is theoretically useful for patients with metal allergies, DCB angioplasty alone for huge plaques in large vessels may yield inadequate luminal enlargement and coronary deep dissection, leading to insufficient results. Directional coronary atherectomy (DCA) is effective to reduce plaque volume. However, the efficacy of DCA followed by DCB (DCA/DCB) angioplasty in patients with metal allergies has never been described. We present two cases wherein stentless PCI with DCA/DCB angioplasty was an alternative revascularization strategy for patients with metal allergy and concomitant worsening angina pectoris involving proximal left anterior descending artery stenoses. Preoperative evaluation using coronary computed tomography angiography in Case 1 and intravascular ultrasound in Case 2 was useful to determine the possible use of the DCA/DCB procedure for huge plaques in large vessels. LEARNING OBJECTIVE: Revascularization for patients with metal allergy with worsening angina pectoris due to stenoses of the proximal main arteries is often challenging because of the necessity to avoid stent implantation. As stentless percutaneous coronary intervention (PCI) is theoretically useful in such settings, PCI with directional coronary atherectomy (DCA)/drug-coated balloon angioplasty can be one of the treatable strategies. Preoperative evaluation of plaque morphology for the suitability of DCA procedure is important.2023年01月, Journal of cardiology cases, 27(1) (1), 32 - 35, 英語, 国内誌
- Glycemic disorders involving large glucose fluctuations and recurrent hypoglycemia may lead to adverse cardiovascular events, including acute coronary syndrome (ACS). Flash glucose monitoring (FGM) has reportedly been useful for detecting latent glycemic disorders. However, only a few studies have so far reported latent glycemic disorders in coronary artery disease. Thus, we herein present a unique case of ACS due to intraplaque hemorrhage in a post-gastrectomy patient who had no apparent coronary risk, except for a latent severe glycemic disorder detected via FGM. This masked etiology should be considered in ACS patients who have no apparent cardiovascular risks in order to improve their cardiovascular outcomes.2023年, Internal medicine (Tokyo, Japan), 62(3) (3), 399 - 403, 英語, 国内誌研究論文（学術雑誌）
- UNLABELLED: Guide-extension catheters (GECs) are effective in providing reinforced backup support and coaxial alignment, leading to successful complex percutaneous coronary intervention (PCI). However, several GEC-associated complications have been reported, including coronary injuries, thrombotic events, and GEC fractures. The Guideplus GEC (Guideplus II ST; Nipro, Osaka, Japan) has a higher crossability due to its unique hydrophilic-coated soft cylinder, which is frequently used in complex PCI for diffuse, tortuous, and heavily calcified lesions. We describe two cases of Guideplus GEC-associated complications during complex PCI: Case 1 with a radiopaque marker dislodgement and Case 2 with a stent dislodgment. In both cases, the Guideplus GEC was used within 7-Fr guiding catheters, employing the mother-and-child technique. A large inner-catheter gap between these catheters caused by a positioning bias due to arterial bends (the aortic arch in Case 1 and brachiocephalic arterial bends in Case 2) may have caused these complications due to its interference with coronary devices (the trapping balloon in Case 1, and the scoring balloon in Case 2). Early cognition and management of these potential Guideplus GEC-associated complications are important to prevent further deterioration. LEARNING OBJECTIVES: The Guideplus guide-extension catheter (GEC) with a hydrophilic-coated soft cylinder can deliver coronary devices to complex lesions owing to its high crossability. However, delivering coronary devices with the Guideplus GEC should be carefully performed because a large inner-catheter gap between Guideplus GEC and a guiding catheter may occur if a proximal port of the Guideplus GEC is located at an arterial bend. In such settings, Guideplus GEC-associated complications must be carefully observed, including radiopaque marker dislodgement and stent dislodgement.2022年12月, Journal of cardiology cases, 26(6) (6), 399 - 403, 英語, 国内誌
- BACKGROUND: Current guidelines equally recommend direct oral anticoagulants (DOACs) and warfarin for atrial fibrillation (AF) patients with a bioprosthetic valve (BPV); however, there are limited data comparing DOACs and warfarin in AF patients with an aortic BPV. METHODS AND RESULTS: This post-hoc subgroup analysis of a multicenter, prospective, observational registry (BPV-AF Registry) aimed to compare DOACs and warfarin in AF patients with an aortic BPV. The primary outcome was a composite of stroke, systemic embolism, major bleeding, heart failure requiring hospitalization, all-cause death, or BPV reoperation. The analysis included 479 patients (warfarin group, n=258; DOAC group, n=221). Surgical aortic valve replacement was performed in 74.4% and 36.7% of patients in the warfarin and DOAC groups, respectively. During a mean follow up of 15.5 months, the primary outcome occurred in 45 (17.4%) and 32 (14.5%) patients in the warfarin and DOAC groups, respectively. No significant difference was found in the primary outcome between the 2 groups (adjusted hazard ratio: 0.88, 95% confidence interval: 0.51-1.50). No significant multiplicative interaction was observed between the anticoagulant effects and type of aortic valve procedure (P=0.577). CONCLUSIONS: Among AF patients with an aortic BPV, no significant difference was observed in the composite outcome of adverse clinical events between patients treated with warfarin and those treated with DOACs, suggesting that DOACs can be used as alternatives to warfarin in these patients.2022年10月, Circulation journal : official journal of the Japanese Circulation Society, 86(11) (11), 1699 - 1707, 英語, 国内誌研究論文（学術雑誌）
- 2022年07月, Circulation reports, 4(7) (7), 333 - 334, 英語, 国内誌研究論文（学術雑誌）
- 2022年07月, Clinical case reports, 10(7) (7), e6104, 英語, 国際誌研究論文（学術雑誌）
- Percutaneous transluminal septal myocardial ablation (PTSMA) is a well-established interventional therapy for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) as an alternative to surgical myectomy. Although guidelines recommend that PTSMA should be performed in institutions with extensive experience, it is not centralized to such high-volume centers in real-world clinical practice. Thus, this study aimed to assess the feasibility of PTSMA in non-high-volume centers. We retrospectively examined patients with HOCM who underwent PTSMA between August 2012 and May 2020 at four institutions that experienced fewer than 20 cases of PTSMA procedures. The primary clinical endpoint was a composite of safety (all-cause death, electrical defibrillation for ventricular tachycardia or fibrillation, cardiac tamponade, permanent pacemaker implantation, and repeated interventions) and efficacy endpoints (repeated interventions [PTSMA or surgical myectomy]). Fifty-eight consecutive patients were enrolled. During the 30-day follow-up, no major clinical adverse events were noted except three patients (5.2%) requiring permanent pacemaker implantation for complete atrioventricular block. The percentage of patients with New York Heart Association functional class 1 or 2 significantly increased from 8.6 to 100% (p < 0.001). In the Cox proportional hazard model, left ventricular outflow tract pressure gradient at rest ≥ 30 mmHg (hazard ratio [HR] 6.56; 95% confidence interval [CI] 1.44-29.90; p = 0.015) and mitral regurgitation grade ≥ 3 (HR 10.75; 95% CI 1.81-63.79; p = 0.009) at the 30-day follow-up were associated with a composite of major clinical adverse events. The current study demonstrated that 58 patients who underwent PTSMA in non-high-volume centers had favorable 30-day clinical outcomes, with a primary composite endpoint rate of 5.2%. A prospective study with a larger sample size and longer follow-up is warranted to verify the safety and efficacy of PTSMA in non-high-volume centers.2022年05月, Heart and vessels, 英語, 国内誌研究論文（学術雑誌）
- 2022年05月, JACC. Cardiovascular interventions, 15(10) (10), e117-e118, 英語, 国際誌研究論文（学術雑誌）
- 2022年05月, Circulation, 145(18) (18), 1434 - 1436, 英語, 国際誌
- Orbital atherectomy (OA) may be effective in managing undilatable in-stent restenosis (ISR) despite off-label indications. We demonstrated that optical frequency domain imaging (OFDI)-guided OA, with a guide-extension system was effective even in distally located, undilatable ISR. However, OFDI revealed that inter-struts calcified neoatherosclerosis remained a challenging issue.2022年05月, Clinical case reports, 10(5) (5), e05798, 英語, 国際誌
- 2022年05月, European heart journal. Case reports, 6(5) (5), ytac186, 英語, 国際誌
- (公社)日本超音波医学会, 2022年04月, 超音波医学, 49(Suppl.) (Suppl.), S702 - S702, 日本語
- Acute decompensated heart failure (ADHF) due to severe aortic stenosis (AS) and concomitant left ventricular outflow tract (LVOT) obstruction is a serious condition. Treatment with medication alone is sometimes difficult, and the efficacy of further interventional strategies has not been fully elucidated. In patients with high surgical risks, combination therapy using transcatheter aortic valve replacement (TAVR) and percutaneous alcohol septal ablation (ASA) is used as a non-surgical intervention. However, this treatment cannot be performed under unstable hemodynamic conditions. This report highlights the utility and efficacy of emergent balloon aortic valvuloplasty (BAV) in controlling heart failure and its potential to serve as a bridge to curative therapy, even in older patients with ADHF due to severe AS with concomitant LVOT obstruction. Furthermore, combination therapy with TAVR and percutaneous ASA could be safely performed after controlling for ADHF using BAV. Non-surgical management is a more feasible treatment option in older patients with ADHF who are at higher risk of complications during surgical intervention.2022年03月, Journal of cardiology cases, 25(3) (3), 188 - 192, 英語, 国内誌
. - BACKGROUND: Although bioprosthetic valve (BPV) replacements are becoming more common within our aging society, there are limited prospective data on the appropriate antithrombotic therapy for East Asian patients with atrial fibrillation (AF) and BPV replacement. Antithrombotic therapy and thrombotic and hemorrhagic event rates in Japanese patients with AF and BPV replacement are investigated. METHODS AND RESULTS: This multicenter, prospective, observational study enrolled patients with BPV replacement and AF. The primary efficacy outcome was stroke or systemic embolism, and the primary safety outcome was major bleeding. Of the 894 patients analyzed, 54.7%, 29.4%, and 9.6%, were treated with warfarin-based therapy, direct oral anticoagulant (DOAC)-based therapy, or antiplatelet therapy without anticoagulants, respectively; 6.3% did not receive any antithrombotic drugs. The mean observation period was 15.3±4.0 months. The event rates for stroke or systemic embolism and major bleeding were 1.95%/year and 1.86%/year, respectively. The multivariate adjusted hazard ratios for DOAC vs. warfarin were 1.02 (95% confidence intervals [CI], 0.30-3.41 [P=0.979]) for systemic embolic events and 0.96 (95% CI, 0.29-3.16 [P=0.945]) for major bleeding. CONCLUSIONS: Approximately 30% of patients with AF and BPV replacement were treated with DOAC. The risks of major bleeding and stroke or systemic embolism were similar between warfarin- and DOAC-treated patients with AF who had BPV replacement. Treatment with DOACs could be an alternative to warfarin in this population.2022年02月, Circulation journal : official journal of the Japanese Circulation Society, 86(3) (3), 440 - 448, 英語, 国内誌研究論文（学術雑誌）
- 2022年02月, Circulation journal : official journal of the Japanese Circulation Society, 86(3) (3), 474 - 474, 英語, 国内誌研究論文（学術雑誌）
- 2022年01月, Circulation journal : official journal of the Japanese Circulation Society, 英語, 国内誌研究論文（学術雑誌）
- 2022年01月, European heart journal. Case reports, 6(1) (1), ytab519, 英語, 国際誌
- 2021年12月, Circulation journal : official journal of the Japanese Circulation Society, 86(1) (1), 169 - 169, 英語, 国内誌研究論文（学術雑誌）
- 2021年11月, JACC. Cardiovascular interventions, 14(22) (22), e313-e316, 英語, 国際誌研究論文（学術雑誌）
- 2021年11月, European heart journal. Cardiovascular Imaging, 英語, 国際誌研究論文（学術雑誌）
- Hyperprolactinemia is a risk factor for thrombus formation. We present a rare case of a mobile ascending aorta thrombus leading to acute myocardial infarction and cerebral infarction in a patient with idiopathic hyperprolactinemia. (Level of Difficulty: Beginner.).2021年08月, JACC. Case reports, 3(9) (9), 1194 - 1199, 英語, 国際誌
- 2021年07月, Clinical Case Reports研究論文（学術雑誌）
- Optical frequency domain imaging-guided additional low-speed rotational atherectomy following sufficient high-speed rotational atherectomy for early calcified in-stent restenosis might be a safe and useful option for achieving additional large lumen gains and stent expansion.2021年07月, Clinical case reports, 9(7) (7), e04550, 英語, 国際誌
- 2021年04月, JACC. Cardiovascular interventions, 14(7) (7), e73-e75, 英語, 国際誌研究論文（学術雑誌）
- 2021年03月, Circulation journal : official journal of the Japanese Circulation Society, 85(4) (4), 397 - 397, 英語, 国内誌研究論文（学術雑誌）
- A 69-year-old female diagnosed with ostial left anterior descending artery acute myocardial infarction underwent percutaneous coronary intervention using combined directional coronary atherectomy followed by drug-coated balloon angioplasty. This report highlights a novel management strategy with no permanent scaffold left in the coronary artery.2021年03月, Clinical case reports, 9(3) (3), 1095 - 1100, 英語, 国際誌
- BACKGROUND: The impact of reduction in glycemic excursion on coronary plaques remains unknown. This study aimed to elucidate whether a dipeptidyl peptidase 4 inhibitor could reduce the glycemic excursion and stabilize the coronary plaques compared with conventional management in coronary artery disease (CAD) patients with impaired glucose tolerance (IGT). METHODS: This was a multicenter, randomized controlled trial including CAD patients with IGT under lipid-lowering therapy receiving either vildagliptin (50 mg once a day) or no medication (control group) regarding glycemic treatment. The primary endpoint was changes in the minimum fibrous cap thickness and lipid arc in non-significant native coronary plaques detected by optical coherence tomography at 6 months after intervention. Glycemic variability expressed as the mean amplitude of glycemic excursion (MAGE) measured with a continuous glucose monitoring system was evaluated before and 6 months after intervention. RESULTS: A total of 20 participants with 47 lesions were allocated to either the vildagliptin group (10 participants, 22 lesions) or the control group (10 participants, 25 lesions). The adjusted difference of mean changes between the groups was - 18.8 mg/dl (95% confidence interval, - 30.8 to - 6.8) (p = 0.0064) for the MAGE (vildagliptin, - 20.1 ± 18.0 mg/dl vs. control, 2.6 ± 12.7 mg/dl), - 22.8° (- 40.6° to - 5.1°) (p = 0.0012) for the mean lipid arc (vildagliptin, - 9.0° ± 25.5° vs. control, 15.8° ± 16.8°), and 42.7 μm (15.3 to 70.1 μm) (p = 0.0022) for the minimum fibrous cap thickness (vildagliptin, 35.7 ± 50.8 μm vs. control, - 15.1 ± 25.2 μm). CONCLUSIONS: Vildagliptin could reduce the MAGE at 6 months and may be associated with the decreased lipid arc and increased minimum FCT of the coronary plaques in CAD patients with IGT as compared with the control group. These findings may represent its potential stabilization effect on coronary plaques, which are characteristic in this patient subset. Trial registration Registered in the UMIN clinical trial registry (UMIN000008620), Name of the registry: VOGUE trial, Date of registration: Aug 6, 2012, URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000010058.2021年02月, BMC cardiovascular disorders, 21(1) (1), 92 - 92, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本心血管インターベンション治療学会, 2021年02月, 日本心血管インターベンション治療学会抄録集, 29回, 985 - 985, 英語STEMI患者におけるOsiro stentとUltimaster stentのstent留置後の血管反応の違い
- 2020年12月, JACC. Cardiovascular interventions, 13(24) (24), 2937 - 2939, 英語, 国際誌研究論文（学術雑誌）
- Background: In this study we investigated the efficacy and safety of very short duration (1-month) dual antiplatelet therapy (DAPT) followed by prasugrel monotherapy. In particular, we compared intrastent conditions using optical coherence tomography (OCT) after second-generation drug-eluting stent implantation between standard-duration and 1-month DAPT followed by prasugrel monotherapy. Methods and Results: Between May 2015 and February 2018, 120 consecutive patients who underwent elective Resolute zotarolimus-eluting stent implantation were enrolled and divided into those receiving standard-duration or 1-month (1M) DAPT followed by prasugrel monotherapy; 47 patients (n=55 stents) and 46 patients (n=54 stents) in the standard and 1M groups, respectively, completed the protocol. The primary endpoint was the prevalence of abnormal intrastent tissue at the 9-month examination, as observed by OCT. The secondary endpoint was the presence of composite adverse events, including all-cause death, myocardial infarction, stent thrombosis, target lesion and vessel revascularization, and major and minor bleeding. The prevalence of abnormal intrastent tissue was similar between the standard and 1M groups (1.6% vs. 1.5%, respectively; non-inferiority P<0.01). There was a tendency for fewer composite events in the 1M than standard group at the 30-month follow-up examination (28.3% vs. 44.7%, respectively; P=0.41). Conclusions: In conclusion, 1M DAPT followed by prasugrel monotherapy after second-generation drug-eluting stent implantation was not inferior to standard-duration DAPT in terms of intrastent thrombus formation and composite adverse events.2020年12月, Circulation reports, 3(1) (1), 55 - 65, 英語, 国内誌研究論文（学術雑誌）
- 2020年11月, JACC. Cardiovascular imaging, 英語, 国際誌
- AIMS: A mineralocorticoid receptor antagonist (MRA) is effective in patients with chronic heart failure; however, the effects of the early initiation of an MRA in patients with acute heart failure (AHF) have not been elucidated. METHODS AND RESULTS: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group study, we focused on the safety and effectiveness of the treatment with eplerenone, a selective MRA in 300 patients with AHF, that is, 149 in the eplerenone group and 151 in the placebo group in 27 Japanese institutions. The key inclusion criteria were (1) patients aged 20 years or older and (2) those with left ventricular ejection fraction of ≤ 40%. The primary outcome was a composite of cardiac death or first re-hospitalization due to cardiovascular disease within 6 months. The mean age of the participants was 66.8 years, 27.3% were women, and the median levels of brain natriuretic peptide were 376.0 pg/mL. The incidences of the primary outcome were 19.5% in the eplerenone group and 17.2% in the placebo group (hazard ratio (HR): 1.09, 95% confidence interval (CI): 0.642-1.855). In prespecified secondary outcomes, HR for the composite endpoint, cardiovascular death, or first re-hospitalization due to heart failure (HF) within 6 months was 0.55 (95% CI: 0.213 to 1.434). The safety profile for eplerenone was as expected. CONCLUSION: The early initiation of eplerenone in patients with AHF could safely be utilized. The reduction of the incidence of a composite of cardiovascular death or first re-hospitalization for cardiovascular diseases by eplerenone is inconclusive because of inadequate power.2020年11月, European heart journal. Cardiovascular pharmacotherapy, 8(2) (2), 108 - 117, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Perigraft inflammatory reactions to prosthetic graft materials in vascular surgery have been reported; however, to our knowledge, this is the first report of a perigraft inflammatory reaction to a Viabahn stent-graft used in a superficial femoral artery occlusion lesion. CASE PRESENTATION: A 76-year-old man with right leg claudication was diagnosed with a right superficial femoral artery occlusion via contrast-enhanced computed tomography. Endovascular treatment included intravascular ultrasound for passing through the true lumen. A 25-cm Viabahn stent-graft (diameter 5 mm) was implanted. The patient developed pain and local swelling of the right thigh 5 days after endovascular treatment. Blood analysis revealed elevated inflammatory marker levels. Magnetic resonance imaging revealed extensive soft-tissue edema and a high perivascular T2 signal around the right superficial femoral artery. Clinical symptoms resolved within 7 days after initiating steroid therapy, which was gradually decreased and halted after 3 weeks. Follow-up magnetic resonance imaging demonstrated substantially reduced inflammation over the following months. CONCLUSIONS: Perigraft inflammatory reaction to a Viabahn stent-graft implant can be immediately diagnosed via magnetic resonance imaging and treated with steroids to reduce the possibility of stent-graft occlusion.2020年09月, CVIR endovascular, 3(1) (1), 49 - 49, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Drug-coated balloon (DCB) treatment for de novo coronary artery disease has demonstrated late lumen enlargement (LLE) in mid-term follow-up and it was considered as clinical benefit; however, its mechanism and the predictive factor remains unclear. METHODS: This study enrolled 46 consecutive patients (54 lesions) treated with DCB, using intravascular ultrasound (IVUS) at the index procedure and at the 9-month follow-up. We measured IVUS parameters at 1-mm intervals and calculated the mean volume of the external elastic membrane (EEM), lumen, and plaque. We calculated the dissection index (DI) defined as summation of the following points, 2: dissection over EEM, 1: intra-EEM dissection, 0: no dissection at every 1-mm interval, and divided by lesion length. RESULTS: IVUS showed that there was no flow limiting dissection just after DCB treatment, the mean EEM and lumen volume (LV) had significantly increased while mean plaque volume had significantly decreased at 9 months, and 74.1% lesions exhibited LLE. We divided the patients into three groups according to delta mean LV. Mean EEM volume significantly increased and mean plaque volume significantly decreased in the larger and smaller LLE groups, but not in the non-LLE group. The DI was higher in a descending order in the three groups. The multiple regression analysis demonstrated that the DI was the strongest predictor of the change in mean LV. CONCLUSIONS: LLE after DCB treatment may be caused by vessel enlargement and plaque regression. The non-flow limiting larger dissection just after DCB treatment may strongly associate with the intending LLE.2020年07月, International journal of cardiology, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- AIM: So far, the mechanisms behind the cardiovascular benefits of sodium/glucose cotransporter 2 (SGLT2) inhibitors have not been fully clarified. METHODS: In order to evaluate the effects of SGLT2 inhibitors on systemic hemodynamics, glucose metabolism, lipid profile, and endothelial function, 50 diabetic patients with established coronary artery disease (CAD) were included in this analysis and were given empagliflozin 10 mg/d. Cookie meal testing (carbohydrates: 75 g, fats: 28.5 g), endothelial function testing using flow-mediated dilatation (FMD), and body composition evaluation were performed before and after six months of treatment. Changes in %FMD between the treatment periods and its association with metabolic biomarkers were evaluated. RESULTS: After six months of treatment, the body weight and body fat percentage decreased significantly, while the body muscle percentage increased significantly. The hemoglobin A1c level and fasting and postprandial plasma glucose levels were significantly decreased with treatment. Postprandial insulin secretion was also significantly suppressed and the insulin resistance index was significantly decreased. Furthermore, the fasting and postprandial triglyceride (TG) levels decreased significantly, while total ketone bodies increased significantly after the six-month treatment. While the plasma brain natriuretic peptide level was not changed, the C-reactive protein level was decreased and FMD was significantly improved after the six-month treatment. Multiple regression analysis showed that the strongest predictive factor of FMD improvement is change in the plasma TG levels. CONCLUSION: SGLT2 inhibitors improve multiple metabolic parameters. Of these, a reduction in plasma TGs was strongly associated with endothelial function recovery in diabetic patients with CAD, and this reduction may be related to the cardiovascular benefits of SGLT2 inhibitors.2020年07月, Journal of atherosclerosis and thrombosis, 27(7) (7), 644 - 656, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本核医学会, 2019年10月, 核医学, 56(Suppl.) (Suppl.), S138 - S138, 日本語半導体D SPECTでのBMIPP/Tc二核種同時収集を直接比較法(ISCH)法で検討する
- (一社)日本心血管インターベンション治療学会, 2019年09月, 日本心血管インターベンション治療学会抄録集, 28回, [MO95 - 001], 英語左冠動脈前下行枝入口部新規病変に対する薬剤溶出性ステントの長期治療成績
- Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) is limited in its ability to detect diffuse interstitial fibrosis, which is commonly found in idiopathic dilated cardiomyopathy (DCM). On the other hand, Washout rate (WR) by cardiac 123I- metaiodobenzylguanidine (123I-MIBG) scintigraphy which evaluates cardiac sympathetic nervous function, is a useful tool for predicting the prognosis in DCM. We investigated the predictive value of the combination of two different types of examinations, LGE on CMR and WR by 123I-MIBG scintigraphy for outcomes in DCM compared with LGE alone. One-hundred forty-eight DCM patients underwent CMR and 123I-MIBG scintigraphy. Patients were divided into 4 groups according to the presence or absence of LGE and WR cut-off value of 45% for predicting prognosis based on receiver operating characteristic curve analysis. Cardiac deaths, re-hospitalization for heart failure, implantation of a left ventricular assist device, and life-threatening ventricular arrhythmias were defined as clinical events. Forty-two DCM patients reached the clinical events during the median follow-up for 9.1 years (interquartile range, 8.0-9.2 years).Multivariable Cox regression analysis identified WR≥45%+LGE positive group as an independent predictor of cardiac events (HR 3.18, 95%CI 1.36-7.45, p = 0.008). Notably, there was no significance in the cardiac event-free survival rate between the WR<45%+LGE positive and WR≥45%+LGE negative groups (p = 0.89). The combination of WR by 123I-MIBG scintigraphy and LGE on CMR, which evaluate different type of cardiac deterioration, serves as a stronger predictor of long-term outcomes in DCM patients than LGE alone.2019年, PloS one, 14(6) (6), e0217865, 英語, 国際誌研究論文（学術雑誌）
- The benefit of revascularization of chronic total occlusion (CTO) in percutaneous coronary intervention (PCI) is controversial. On the other hand, left ventricular (LV) global longitudinal strain (GLS) is a more sensitive marker of LV myocardial ischemia and LV function than LV ejection fraction (EF). The purpose of this study was to investigate the impact of revascularization of CTO on LV function using LV GLS. A total of 70 consecutive patients (65.1±8.9 years, 59 males, LVEF 51.0±12.0%) with CTO who had a positive functional ischemia and underwent PCI, were included in this study. Echocardiography was performed before and 9 months after the procedure with conventional assessment including LV end-diastolic and end-systolic volume (LVEDV, LVESV), LVEF, and with 2DSTE analysis of GLS. Successful PCI was obtained in 60 patients (86%). There were no stent thromboses during follow-up. GLS showed a significant improvement 9 months after successful PCI (pre-PCI -12.4±4.1% vs. post-PCI -14.5±4.1%, P< 0.01), whereas in failed PCI group that did not change significantly (pre-PCI -13.2±4.2% vs. post-PCI -14.0±4.7%, P = 0.64). LVEF, LVEDV and LVESV did not change significantly during follow-up in both successful and failed groups. Successful PCI for CTO improved LV function, assessed by LV GLS.2019年, PloS one, 14(6) (6), e0217092, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本核医学会, 2018年11月, 核医学, 55(Suppl.) (Suppl.), S186 - S186, 日本語心疾患診断における半導体ガンマカメラでの123Iと99mTc二核種同時収集の有用性
- BACKGROUND: Previous studies suggest that the pathophysiology of heart failure with preserved ejection fraction (HFpEF) is characterized not only by high ventricular stiffness, but also by vascular stiffness. Azilsartan has higher vascular affinity compared with other angiotensin II receptor blockers (ARBs), which were proven to have no beneficial effects on clinical outcomes in patients with HFpEF in earlier clinical trials. We aimed to test the hypothesis that azilsartan may improve left ventricular diastolic function in HFpEF patients with hypertension in this trial. METHODS: The Effects of Angiotensin Receptor Blockers on Diastolic Function in Patients Suffering from Heart Failure with Preserved Ejection Fraction: J-TASTE trial is a multicenter, randomized, open-labeled, and assessor(s)-blinded, active controlled using candesartan, parallel-group clinical trial, to compare changes in left ventricular (LV) diastolic dysfunction between HFpEF patients with hypertension who have received candesartan or azilsartan for 48 weeks. The primary endpoint is the change in early diastolic wave height/early diastolic mitral annulus velocity (E/e') assessed by echocardiography from the baseline to the end of the study (48 weeks). A total of 190 patients will be recruited into the study. CONCLUSIONS: The design of the J-TASTE trial will provide data on whether differences between the effects of the two tested drugs on LV diastolic function exist in HFpEF patients with hypertension and will improve understanding of the pathophysiological role of vascular stiffness on diastolic function.2018年08月, Cardiovascular drugs and therapy, 32(4) (4), 381 - 388, 英語, 国際誌研究論文（学術雑誌）
- Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai), 2018年07月, Journal of Cardiology, 72(1) (1), 66 - 73, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本循環器学会, 2018年03月, 日本循環器学会学術集会抄録集, 82回, OJ10 - 2, 英語Empagliflozineによる血漿トリグリセリド改善効果は冠動脈疾患のある糖尿病患者における内皮細胞機能回復と関連する(Ameliorating Effect of Empagliflozine on Plasma Triglyceride is Associated with Endothelial Function Recovery in Diabetic Patients with Coronary Artery Disease)
- Echocardiography plays a pivotal role as an imaging modality in the modern cardiology practice. Information derived from echocardiography is definitely helpful for a patient care. The Japanese Society of Echocardiography has promoted echocardiography for a routine clinical and research use. One of the missions of the Society is to provide information that is useful for high-quality examinations. To ensure it, we believe equipment in good conditions and a comfortable environment are important for both a patient and an examiner. Thus, the Committee for Guideline Writing, the Japanese Society of Echocardiography published brief guidance for the routine use of echocardiography equipment in 2015. Recently, the importance of international standardization has been emphasized in the medical laboratories. Accordingly, the committee has revised and updated our guidance for the routine use of echocardiography equipment.2018年03月, Journal of echocardiography, 16(1) (1), 1 - 5, 英語, 国内誌研究論文（学術雑誌）
- 2017年08月, CASE (Philadelphia, Pa.), 1(4) (4), 134 - 137, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVE: Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging has been reported to be associated with unfavourable outcomes; however, few studies have addressed the prognostic value of left ventricular (LV) deformation parameter indicated by global longitudinal strain (GLS) in two-dimensional speckle-tracking (2DST) echocardiography in patients with non-ischaemic dilated cardiomyopathy (DCM). This study aims to investigate whether the combination of GLS and LGE is useful in stratifying the risk in patients with DCM. METHODS: We studied 179 consecutive symptomatic patients with DCM (age, 61±15 years; 121 males; left ventricular ejection fraction (LVEF) 33%±9%; New York Heart Association (NYHA) class II: n=71, III: n=107, IV: n=1) who underwent CMR and echocardiography with conventional assessment and 2DST analysis. RESULTS: There were 40 rehospitalisations for heart failure, including 7 cardiac deaths and 2 implantations of LV assist device during follow-up (3.8±2.5 years). Univariable Cox proportional hazard regression analysis showed that NYHA class, blood pressure, B-type natriuretic peptide, LV end-diastolic and end-systolic volumes, LVEF, left atrium volume, GLS and LGE were significantly associated with long-term outcome. Multivariable analysis revealed that GLS and LGE were independently associated with long-term outcome (p<0.05, both). In additional analyses, we found independent associations between GLS and LV reverse remodelling after the optimal medical therapy, and between LGE and life-threatening arrhythmias (p<0.05, both). CONCLUSION: Combining GLS and LGE could be useful for risk stratification and prognostic assessment in patients with DCM.2017年05月, Heart (British Cardiac Society), 103(9) (9), 679 - 686, 英語, 国際誌研究論文（学術雑誌）
- 2017年, DIGESTIVE SURGERY, 34(2) (2), 114 - 124, 英語[査読有り]研究論文（学術雑誌）
- Springer Tokyo, 2016年12月, Journal of Echocardiography, 14(4) (4), 163 - 170, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: Recent experimental studies have revealed that n-3 fatty acids, such as eicosapentaenoic acid (EPA) regulate postprandial insulin secretion, and correct postprandial glucose and lipid abnormalities. However, the effects of 6-month EPA treatment on postprandial hyperglycemia and hyperlipidemia, insulin secretion, and concomitant endothelial dysfunction remain unknown in patients with impaired glucose metabolism (IGM) and coronary artery disease (CAD). METHODS AND RESULTS: We randomized 107 newly diagnosed IGM patients with CAD to receive either 1800 mg/day of EPA (EPA group, n = 53) or no EPA (n = 54). Cookie meal testing (carbohydrates: 75 g, fat: 28.5 g) and endothelial function testing using fasting-state flow-mediated dilatation (FMD) were performed before and after 6 months of treatment. The primary outcome of this study was changes in postprandial glycemic and triglyceridemic control and secondary outcomes were improvement of insulin secretion and endothelial dysfunction. After 6 months, the EPA group exhibited significant improvements in EPA/arachidonic acid, fasting triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). The EPA group also exhibited significant decreases in the incremental TG peak, area under the curve (AUC) for postprandial TG, incremental glucose peak, AUC for postprandial glucose, and improvements in glycometabolism categorization. No significant changes were observed for hemoglobin A1c and fasting plasma glucose levels. The EPA group exhibited a significant increase in AUC-immune reactive insulin/AUC-plasma glucose ratio (which indicates postprandial insulin secretory ability) and significant improvements in FMD. Multiple regression analysis revealed that decreases in the TG/HDL-C ratio and incremental TG peak were independent predictors of FMD improvement in the EPA group. CONCLUSIONS: EPA corrected postprandial hypertriglyceridemia, hyperglycemia and insulin secretion ability. This amelioration of several metabolic abnormalities was accompanied by recovery of concomitant endothelial dysfunction in newly diagnosed IGM patients with CAD. Clinical Trial Registration UMIN Registry number: UMIN000011265 ( https://www.upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000013200&language=E ).2016年08月, Cardiovascular diabetology, 15(1) (1), 121 - 121, 英語, 国際誌研究論文（学術雑誌）
- 2016年06月, Journal of echocardiography, 14(2) (2), 47 - 8, 英語, 国内誌研究論文（学術雑誌）
- 2016年06月, Journal of echocardiography, 14(2) (2), 49 - 52, 英語, 国内誌Erratum to: Guidelines for conducting transesophageal echocardiography (TEE) : Task force for guidelines for conducting TEE: November 15, 2015.研究論文（学術雑誌）
- BACKGROUND: Even with the use of a reduced energy setting (20-25 W), excessive transmural injury (ETI) following catheter ablation of atrial fibrillation (AF) is reported to develop in 10% of patients. However, the incidence of ETI depends on the pulmonary vein isolation (PVI) method and its esophageal temperature monitor setting. Data comparing the incidence of ETI following AF ablation with and without esophageal temperature monitoring (ETM) are still lacking. METHODS: This study was comprised of 160 patients with AF (54% paroxysmal, mean: 24.0±2.9 kg/m(2)). Eighty patients underwent ablation accompanied by ETM. The primary endpoint was defined as the occurrence of ETI assessed by endoscopy within 5 d after the AF ablation. The secondary endpoint was defined as AF recurrence after a single procedure. If the esophageal temperature probe registered >39 °C, the radiofrequency (RF) application was stopped immediately. RF applications could be performed in a point-by-point manner for a maximum of 20 s and 20 W. ETI was defined as any injury that resulted from AF ablation, including esophageal injury or periesophageal nerve injury (peri-ENI). RESULTS: The incidence of esophageal injury was significantly lower in patients whose AF ablation included ETM compared with patients without ETM (0 [0%] vs. 6 [7.5%], p=0.028), but not the incidence of peri-ENI (2 [2.5%] vs. 3 [3.8%], p=1.0). AF recurrence 12 months after the procedure was similar between the groups (20 [25%] in the ETM group vs. 19 [24%] in the non-ETM group, p=1.00). CONCLUSIONS: Catheter ablation using ETM may reduce the incidence of esophageal injury without increasing the incidence of AF recurrence but not the incidence of peri-ENI.2016年02月, Journal of arrhythmia, 32(1) (1), 36 - 41, 英語, 国内誌研究論文（学術雑誌）
- 2016年02月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43(2) (2), 495 - 503, 英語[査読有り]研究論文（学術雑誌）
- 2015年11月, JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 26(11) (11), 1239 - 1246, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: Usually, the pulmonary venous and left atrial (PV-LA) anatomy is assessed with contrast-enhanced computed tomographic imaging for catheter ablation of atrial fibrillation (AF). A non-contrast-enhanced magnetic resonance (MR) imaging method has not been established. Three-dimensional balanced steady-state free precession (3D b-SSFP) sequences cannot visualize the PV-LA anatomy simultaneously because of the signal intensity defect of pulmonary veins. We compared two-dimensional (2D) b-SSFP sequences with 3D b-SSFP sequences in depicting the PV-LA anatomy with non-contrast-enhanced MR imaging for AF ablation. METHODS: Eleven healthy volunteers underwent non-contrast-enhanced MR imaging with 3D b-SSFP and 2D b-SSFP sequences. The MR images were reconstructed on the 3D PV-LA surface image. Two experienced radiological technicians independently scored the multiplanar reformatted (MPR) images on a scale of 1-4 (from 1, not visualized, to 4, excellent definition). The overall score was a sum of 5 segments (LA and 4 PVs). RESULTS: In the 2D b-SSFP method, MR imaging was successfully performed, and the 3D PV-LA surface image was precisely reconstructed in all healthy volunteers. The image score was significantly higher in the 2D b-SSFP method compared to the 3D b-SSFP method (19 [19; 20] vs. 12 [11; 15], p=0.004, for both observers). No PV signal intensity defects occurred in the 2D b-SSFP method. CONCLUSIONS: The 2D b-SSFP sequence was more useful than the 3D b-SSFP sequence in adequately depicting the PV-LA anatomy.2015年08月, Journal of arrhythmia, 31(4) (4), 189 - 95, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The radiofrequency (RF) lesions for atrial fibrillation (AF) ablation can be visualized by delayed enhancement magnetic resonance imaging (DE-MRI). However, the quality of anatomical information provided by DE-MRI is not adequate due to its spatial resolution. In contrast, magnetic resonance angiography (MRA) provides similar information regarding the left atrium (LA) and pulmonary veins (PVs) as computed tomography angiography. We hypothesized that DE-MRI fused with MRA will compensate for the inadequate image quality provided by DE-MRI. METHODS: DE-MRI and MRA were performed in 18 patients who underwent AF ablation (age, 60±9 years; LA diameter, 42±6 mm). Two observers independently assessed the DE-MRI and DE-MRI fused with MRA for visualization of the RF lesion (score 0-2; where 0: not visualized and 2: excellent in all 14 segments of the circular RF lesion). RESULTS: DE-MRI fused with MRA was successfully performed in all patients. The image quality score was significantly higher in DE-MRI fused with MRA compared to DE-MRI alone (observer 1: 22 (18, 25) vs 28 (28, 28), p<0.001; observer 2: 24 (23, 25) vs 28 (28, 28), p<0.001). CONCLUSIONS: DE-MRI fused with MRA was superior to DE-MRI for visualization of the RF lesion owing to the precise information on LA and PV anatomy provided by DE-MRI.2015年06月, Journal of arrhythmia, 31(3) (3), 152 - 8, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Atrial tissue fibrosis has previously been identified using delayed-enhancement MRI (DE-MRI) in patients with atrial fibrillation (AF). Although the clinical importance of DE-MRI is well recognized, the visualization of atrial fibrosis and radiofrequency (RF) lesions has still not been achieved in Japan, primarily because of the differences in contrast agents, volume-rendering tools, and technical experience. The objective of this study was to visualize RF lesions by using commercially available tools. METHODS: DE-MRI was performed in 15 patients who had undergone AF ablation (age, 59±4 years, left atrium diameter, 40±2 mm). Specific parameters for MR scanning obtained from previous reports were modified. RESULTS: Of the 15 images, the images of three patients were uninterpretable owing to low image quality. RF lesions could be visualized in 8 (67%) of the 12 patients. CONCLUSIONS: In the current study, we successfully demonstrated that RF lesions could be visualized in Japanese patients using DE-MRI, although only commercially available tools were used.2015年04月, Journal of arrhythmia, 31(2) (2), 71 - 5, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Esophageal injury following catheter ablation of atrial fibrillation (AF) is reported to occur in 35% of patients. Even with a low energy setting (20-25 W), lesions develop in 10% of patients. Body mass index (BMI) has been reported to be a predictor of esophageal injury, indicating that patients with a low BMI (<24.9 kg/m(2)) are at a higher risk. We hypothesized that catheter ablation with a lower energy setting of 20 W controlled by esophageal temperature monitoring (ETM) at 39 °C could prevent esophageal injury even in patients with a BMI <24.9 kg/m(2). METHODS: Twenty patients with AF were included (age, 63±8 years; BMI, 22.9±1.3 kg/m(2), left atrium diameter, 44±11 mm). If the esophageal temperature probe registered a temperature of >39 °C, radiofrequency (RF) application was stopped immediately. RF application could be performed in a "point by point" manner for a maximum of 20 s. Endoscopy was performed 1-5 days after ablation. RESULTS: Esophageal mucosal injury was not observed in any patient in the study. CONCLUSIONS: Catheter ablation using ETM reduced the incidence of esophageal injuries, even in patients with a low BMI.2015年02月, Journal of arrhythmia, 31(1) (1), 12 - 7, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: We sought to identify the feasibility of speckle tracking echocardiography (STE) to predict cardiac resynchronization therapy (CRT) responders in a prospective multicenter study. METHODS AND RESULTS: Patients who were newly implanted with a CRT device were enrolled. Time (T) from QRS to maximum peak radial and circumferential strain (CS) in 6 segments on the left ventricular (LV) short-axis plane, and to the maximum peak of longitudinal strain in 18 segments on 3 apical LV planes was measured (Tmax). In segments with multiple peaks on the time-strain curves, time to the first peak (Tfirst) was also assessed. Difference in T between the earliest and latest segment and standard deviation (SD) of T in each strain component were assessed. CRT responders were defined as having LV end-systolic volume reduction >15% at 6 months after CRT. Clinical outcomes were assessed with a composite endpoint of death from cardiac causes or unplanned hospitalization for heart failure. Among 180 patients, 109 patients were identified as responders. Tfirst-SD of CS >116 ms was selected as the best independent predictor of CRT responders (P<0.001, hazard ratio=9.83, 95% confidence interval 3.78-25.6). In addition, Tfirst-SD of CS was associated with the clinical endpoints. CONCLUSIONS: This prospective multicenter study revealed the high feasibility of dyssynchrony assessment by STE, which may improve the ability to predict CRT responders.2015年, Circulation journal : official journal of the Japanese Circulation Society, 79(3) (3), 613 - 22, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The incidence of hematoma formation following implantation of a cardiovascular implantable electronic device (CIED) is estimated to be 5% even if a pressure dressing is applied. It is unclear whether a pressure dressing can really compress the pocket in different positions. Furthermore, the adhesive tape for fixing pressure dressings can tear the skin. We developed a new compression tool for preventing hematomas and skin erosions. METHODS AND RESULTS: We divided 46 consecutive patients receiving anticoagulation therapy who underwent CIED implantation into 2 groups (Group I: conventional pressure dressing, Group II: new compression tool). The pressure on the pocket was measured in both the supine and standing positions. The incidence of hematomas was compared between the 2 groups. The pressure differed between the supine and standing positions in Group I, but not in Group II (Group I: 14.8±7.1 mmHg vs. 11.3±9.9 mmHg, P=0.013; Group II: 13.5±2.8 mmHg vs. 13.5±3.5 mmHg, P=0.99). The incidence of hematomas and skin erosions was documented in 2 (8.7%) and 3 (13%) Group I patients, respectively. No complications were documented in Group II. CONCLUSIONS: The new compression tool can provide adequate continuous pressure on the pocket, regardless of body position. This device may reduce the incidence of hematomas and skin erosions after CIED implantation.2015年, Circulation journal : official journal of the Japanese Circulation Society, 79(8) (8), 1727 - 32, 英語, 国内誌研究論文（学術雑誌）
- Elsevier, 2015年, Journal of Arrhythmia, 31(5) (5), 286 - 292, 英語[査読有り]研究論文（学術雑誌）
- 2015年, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 14(4) (4), 367 - 372, 英語[査読有り]研究論文（学術雑誌）
- 2014年12月, JOURNAL OF ARRHYTHMIA, 30(6) (6), 515 - 518, 英語研究論文（学術雑誌）
- Elsevier, 2014年12月, Journal of Arrhythmia, 30(6) (6), 491 - 495, 英語[査読有り]研究論文（学術雑誌）
- (公財)日本心臓財団, 2014年11月, 心臓, 46(11) (11), 1538 - 1542, 日本語
- 2014年10月, JOURNAL OF NUCLEAR CARDIOLOGY, 21(5) (5), 1023 - 1028, 英語[査読有り]研究論文（学術雑誌）
- 2014年09月, NUCLEAR MEDICINE COMMUNICATIONS, 35(9) (9), 939 - 946, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: Anthracycline chemotherapy generates progressive dose-dependent left ventricular (LV) dysfunction associated with a poor prognosis. Early detection of minor LV myocardial dysfunction caused by the cardiotoxicity of anthracycline is thus important for predicting global LV dysfunction. METHODS: Fifty patients with preserved ejection fraction (all ≥55%) after receiving anthracycline chemotherapy were recruited for this study. Two-dimensional speckle tracking was used to assess global radial and circumferential strains from mid-LV short-axis views and global longitudinal strain from the apical four- and two-chamber view as peak global strain curves. Three-dimensional (3D) radial, circumferential, and longitudinal myocardial function was quantified as a peak global strain curve using 3D speckle tracking from all 16 LV segments. 3D speckle tracking imaging was used to evaluate LV endocardial area change ratio (area strain) quantified as peak global area strain curve (3D-GAS) to determine LV endocardial function. Twenty age-, gender-, and EF-matched normal volunteers were studied for comparisons. RESULTS: Only 3D-GAS and peak 3D global circumferential strains of the anthracycline group were significantly worse than those of the control group (-43.3 ± 3.1 vs. -45.8 ± 4.3% and -31.6 ± 3.5% vs. -34.4 ± 4.2%, respectively; P = 0.008, P = 0.004) even though global LV systolic and diastolic functions were similar. 3D-GAS correlated significantly with the cumulative doxorubicin dose (r = 0.316, P = 0.026). It was noteworthy that multivariate analysis showed only 3D-GAS (β = 0.323, P = 0.025) was independently associated with cumulative doxorubicin dose. CONCLUSIONS: Three-dimensional speckle tracking area strain was found useful for early detection of minor LV endocardial dysfunction associated with the use of anthracycline, and may thus prove to be clinically useful for predicting global LV dysfunction.2014年08月, Echocardiography (Mount Kisco, N.Y.), 31(7) (7), 848 - 57, 英語, 国際誌[査読有り]
- (公社)日本超音波医学会, 2014年04月, 超音波医学, 41(Suppl.) (Suppl.), S532 - S532, 日本語
- BACKGROUND: The importance of left atrial (LA) functional reserve in patients with depressed left ventricular function remains unclear. Thus, the aim of this study was to test the hypothesis that diminished augmentation of LA function during dobutamine stress might be associated with cardiovascular events in patients with dilated cardiomyopathy. METHODS: Eighty-four patients with dilated cardiomyopathy with a mean ejection fraction of 34 ± 9% were retrospectively recruited, and LA strain was determined as the averaged global speckle-tracking longitudinal strain from apical four-chamber and two-chamber views during dobutamine stress (20 μg/kg/min). The systolic component of LA strain was considered to reflect reservoir function, whereas the passive and active emptying components were considered to reflect passive and active emptying function, respectively. Event-free survival was tracked for 17 months. RESULTS: Multivariate Cox proportional-hazards analysis identified LA volume index (hazard ratio [HR], 1.060; P < .001) and β-blocker use (HR, 0.048; P < .05) as the independent variables associated with cardiovascular events among the baseline parameters and changes in systolic LA strain (HR, 0.971; P = .02), in passive emptying LA strain (HR, 0.942; P < .001), and in left ventricular early diastolic strain rate (HR, 0.986; P = .03) under dobutamine as the variables among the functional reserve parameters. In sequential Cox models, a model based on clinical variables (χ(2) = 9.3) was improved by conventional echocardiographic parameters (χ(2) = 19.2, P = .012) and LA strain parameters at rest (χ(2) = 40.1, P = .005) and further improved by the addition of changes in LA strain parameters under dobutamine (χ(2) = 61.6, P < .001). CONCLUSIONS: The assessment of LA reservoir and passive emptying function during dobutamine stress provides important incremental prognostic value in patients with dilated cardiomyopathy.2014年04月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 27(4) (4), 430 - 9, 英語, 国際誌[査読有り]
- 2014年04月, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 31(4) (4), 464 - 473, 英語[査読有り]研究論文（学術雑誌）
- Easy-to-use comprehensive speckle-tracking approach for cardiac resynchronization therapy.BACKGROUND: Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to the patient's response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, are also influential. METHODS AND RESULTS: We studied 132 patients undergoing CRT. LV dyssynchrony was determined by anteroseptal-to-posterior wall delay on the mid-LV short-axis view using 2-dimensional speckle-tracking radial strain (≥130 ms as significant). Global circumferential strain (GCS), considered as a parameter of LV intrinsic myocardial function, was also determined as the peak GCS from the same view. Long-term follow-up was tracked over 40 months. Kaplan-Meier analysis indicated that patients with GCS >3.9% experienced fewer cardiovascular events overall (log-rank P=0.034). Similarly, patients with GCS >3.9% and ≥6.6% experienced fewer cardiovascular events than those with GCS ≤3.9% and <6.6% among patients with and without LV dyssynchrony (log-rank P=0.025 and P=0.029, respectively). An important finding from multivariate Cox proportional hazards analysis was that LV dyssynchrony and GCS were independently associated with cardiovascular events. Of note, only 2±1 min per patient were needed to analyze both LV dyssynchrony and GCS from the same routine mid-LV short-axis view. CONCLUSIONS: This easy-to-use combined assessment of LV dyssynchrony and myocardial function using speckle-tracking strain from the same mid-LV short-axis view may well have clinical implications for CRT.2014年, Circulation journal : official journal of the Japanese Circulation Society, 78(9) (9), 2250 - 8, 英語, 国内誌[査読有り]
- A case was 53-year-old female with dilated-phase hypertrophic cardiomyopathy. She was classified as New York Heart Association functional class III heart failure despite receiving optimal medical therapy. The electrocardiogram taken showed intraventricular conduction delay with a QRS width of 194 msec. The left ventricular (LV) end-diastolic and systolic volumes, and ejection fraction (EF) were 101 mL, 68 mL, and 32%, respectively. The patient showed no significant mechanical LV dyssynchrony as evidenced by two-dimensional (2D) speckle tracking radial strain, which is defined as the time difference between anterior-septum and posterior wall, of 105 msec (<130 msec). Three-dimensional (3D) speckle tracking radial strain was performed for more detailed LV mechanical dyssynchrony analysis. An especially important finding for 3D speckle tracking radial strain analysis was that the average time-to-peak strain of 5 septum segments at 3 different LV levels (basal-anterior-septum, basal-septum, mid-anterior-septum, mid-septum, apical-septum) was significantly shorter than that of 5 posterolateral segments at 3 different LV levels (basal-posterior, basal-lateral, mid-posterior, mid-lateral, apical-lateral). This time difference between septum and posterolateral wall was 216 msec (204 msec vs. 420 msec), which was considered to indicate significant LV mechanical dyssynchrony (≥130 msec). 12 months after cardiac resynchronization therapy (CRT), EF had improved to 47%, while end-systolic and diastolic volumes had decreased to 88 mL and 47 mL, respectively, so that the patient was classified as a responder. In conclusions, a newly developed 3D speckle tracking strain can provide a comprehensive evaluation of "true" LV mechanical dyssynchrony from pyramidal 3D data sets acquired in the same beat, thus yielding more accurate information than previously possible with the 2D speckle tracking system.2013年10月, Echocardiography (Mount Kisco, N.Y.), 30(9) (9), E292-5, 英語, 国際誌[査読有り]
- 2013年05月, HYPERTENSION, 61(5) (5), 1002 - +, 英語[査読有り]研究論文（学術雑誌）
- AIMS: It remains difficult to detect subtle left ventricular (LV) myocardial dysfunction in chronic aortic regurgitation (AR) patients with the preserved ejection fraction (EF). METHODS AND RESULTS: We studied 36 chronic severe AR patients undergoing surgical correction with the EF of 58 ± 6% (all ≥ 50%). Echocardiography was performed before and 12 ± 8 months after surgical correction. We used two-dimensional speckle-tracking strain imaging to evaluate global radial strain in the inner-half (GRSinner), outer-half (GRSouter), and total (GRStotal) layer from the mid-LV short-axis view. We also evaluated the transmural strain profile in the LV posterior wall by using myocardial tissue Doppler radial strain, and the location of peak strain was determined as the percentage of the distance from the endocardium to the epicardium accounted for by the wall thickness. Fifteen EF-matched normal volunteers were studied for comparison. GRSinner for AR patients was significantly smaller than that for controls (28.9 ± 12.9 vs. 37.1 ± 9.1%, P = 0.032), and the location of peak strain had significantly shifted to the epicardial side compared with that in controls (27.1 ± 14.0-13.2 ± 4.8%, P = 0.001). In contrast, GRStotal and GRSouter were similar for the two groups. After surgical correction, EF increased from 58 ± 6 to 62 ± 7% (P = 0.018), GRSinner from 27.8 ± 12.5 to 37.7 ± 14.6% (P < 0.0001), and the location of peak strain significantly shifted to the endocardial side (26.9 ± 13.9-19.1 ± 11.9%, P = 0.028). However, GRStotal and GRSouter did not change. CONCLUSION: The LV endocardium side, impaired in chronic AR patients with the preserved EF, improved after surgical correction. Our observations may prove useful for evaluating subtle early changes in such patients.2013年04月, European heart journal cardiovascular Imaging, 14(4) (4), 339 - 46, 英語, 国際誌[査読有り]
- Myocardial damage in Duchenne muscular dystrophy (DMD) has lethal outcomes, making early detection of myocardial changes in patients with DMD vital, because early treatment can help prevent the development of myocardial fibrosis. The aim of the present study was, therefore, to test the hypothesis that transmural strain profile (TMSP) analysis can predict future left ventricular (LV) dysfunction in patients with DMD with preserved ejection fraction. We studied 82 consecutive patients with DMD without LV wall motion abnormality, with an ejection fraction of 60 ± 5% (all ≥55%) and age 11 ± 3 years. Echocardiography was performed at baseline and 1 year of follow-up. TMSP in the posterior wall was evaluated from the mid-LV short-axis view. A normal TMSP pattern (1 peak in the endocardium, group 1) was seen in 44 patients, and TMSP with a notch (2 peaks in the endocardium, group 2) in the remaining 38 (46%). Wall motion abnormality in the posterior wall was observed in 16 patients (42%) in group 2 at 1 year of follow-up but in none of the patients in group 1 (42% vs 0%; p <0.001). Importantly, multivariate analysis showed that only TMSP with a notch (odds ratios 1.524, p <0.001) was an independent determinant of the presence of LV posterior wall motion abnormality at 1 year of follow-up. In conclusion, subclinical LV dysfunction can be detected by evaluation of TMSP in patients with DMD who do not have wall motion abnormalities by conventional echocardiography. TMSP with a notch proved effective for evaluating subtle early changes in patients with DMD and might be useful for predicting LV dysfunction.2013年03月, The American journal of cardiology, 111(6) (6), 902 - 7, 英語, 国際誌[査読有り]
- 2013年03月, CIRCULATION JOURNAL, 77(3) (3), 756 - 763, 英語[査読有り]研究論文（学術雑誌）
- 2013年02月, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 30(2) (2), 147 - 154, 英語[査読有り]研究論文（学術雑誌）
- Since cardiac sarcoidosis (CS) leads to substantial morbidity and sudden death, early diagnosis and appropriate management are crucial for patients with CS. Echocardiography used to be considered a useful diagnostic tool for patients with CS, but CS may clinically present as dilated cardiomyopathy (DCM). Our objective was to investigate whether a novel three-dimensional (3-D) speckle-tracking strain can identify patients with CS more accurately. We studied 23 CS patients with an ejection fraction (EF) of 46 ± 10 %, and 16 EF-matched patients with DCM (EF 45 ± 11 %). Global radial (GRS), circumferential (GCS) and longitudinal (GLS) strain was assessed using 3-D speckle-tracking system. GRS of patients with CS was significantly lower than that of patients with DCM (18.5 ± 8.4 vs. 28.5 ± 8.3 %, p < 0.01), but GCS and GLS in patients with CS and DCM were similar. GRS ≦ 21.1 could differentiate CS from DCM with a sensitivity of 70 %, specificity of 88 % and area under the curve of 0.79. An additional noteworthy findings was that, patients with CS showed more negative radial strain curves than did those with DCM (1.7 ± 2.3 vs. 0.1 ± 0.5, p < 0.01). In conclusion, 3-D speckle-tracking radial strain shows good potential to distinguish CS from DCM. Our observations can thus be expected to have clinical implications for management of CS patients.2013年02月, The international journal of cardiovascular imaging, 29(2) (2), 317 - 24, 英語, 国際誌[査読有り]
- Rapid progression of neuromuscular disorder related cardiomyopathy in a young patient.An 11-year and 3-month-old boy with a neuromuscular disorder was admitted for dyspnea. Echocardiography revealed severe left ventricular dysfunction with an ejection fraction (EF) of 17%. However, the EF had been 57% when the patient was 10 years and 9 months old. The patient's clinical condition became refractory, and he died on the 155th day of hospitalization. Speckle-tracking analysis was retrospectively performed, which demonstrated that the global radial strain was within the normal range; however, the global longitudinal and circumferential strains were lower -than -normal 10 years and 9 months of age. Adult neuromuscular disorder-related secondary cardiomyopathy generally progresses slowly, although progression depends on the age of onset of cardiomyopathy.2013年, Internal medicine (Tokyo, Japan), 52(24) (24), 2771 - 5, 英語, 国内誌研究論文（学術雑誌）
- 2013年, INTERNAL MEDICINE, 52(1) (1), 71 - 74, 英語[査読有り]研究論文（学術雑誌）
- Dynamic left ventricular dyssynchrony assessed on 3-dimensional speckle-tracking area strain during dobutamine stress has a negative impact on cardiovascular events in patients with idiopathic dilated cardiomyopathy.BACKGROUND: Left ventricular (LV) dyssynchrony is not a stable phenomenon, but rather, changes dynamically. Given that the prognostic impact of dynamic dyssynchrony has not yet been elucidated, the objective was to investigate the clinical impact of dynamic dyssynchrony on patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: Seventy DCM patients with ejection fraction 32±9% were retrospectively recruited, and 3-dimensional speckle-tracking area strain was used to measure both contractile reserve and changes in dyssynchrony during dobutamine stress. The standard deviation of time-to-peak area strain was adopted as the systolic dyssynchrony index. Event-free survival was then tracked over a 13-month period. A ≥7.55% increase in systolic dyssynchrony index during dobutamine stress (Δsystolic dyssynchrony index) was the best predictor of cardiovascular events with 77% sensitivity and 88% specificity. Multivariate Cox analysis indicated that not only the absence of contractile reserve (Δglobal area strain ≤21.1%: hazard ratio [HR], 15.29; P=0.01), but the presence of dynamic dyssynchrony (ΔLV dyssynchrony ≥7.55%: HR: 7.591; P=0.003) was an independent predictor of cardiovascular events. Importantly, absence of dynamic dyssynchrony and presence of contractile reserve were associated with the most favorable outcome (98%), whereas the reverse condition was associated with the worst outcome (20%, P<0.001). CONCLUSIONS: Dynamic dyssynchrony is a potential predictor of cardiovascular events in patients with DCM, while assessment of dynamic dyssynchrony in combination with contractile reserve may further improve prognostic risk stratification.2013年, Circulation journal : official journal of the Japanese Circulation Society, 77(7) (7), 1750 - 9, 英語, 国内誌[査読有り]
- Although left ventricular (LV) mechanical dyssynchrony can predict the response to cardiac resynchronization therapy (CRT), the presence of baseline LV dyssynchrony might not be the only determinant of the response to CRT. The objectives of the present study were to test the hypothesis that a combined assessment of baseline LV dyssynchrony and its acute improvement can produce a more accurate prediction of the long-term outcomes after CRT. We studied 121 patients with heart failure undergoing CRT. LV dyssynchrony was determined by measuring the anteroseptal-to-posterior wall time delay using the speckle-tracking radial strain (≥130 ms was predefined as significant) and was assessed at baseline and 7 ± 3 days after CRT. Long-term unfavorable outcome events were tracked for 5 years. Acute improvement in LV dyssynchrony of ≥33% was predictive of the long-term outcome with an area under the curve of 0.67 (p = 0.0024). Using this cutoff value, the Kaplan-Meier curve showed that patients with acute improvement in LV dyssynchrony experienced fewer cardiovascular events than those without (log-rank p = 0.0002). The event-free survival of patients whose baseline LV dyssynchrony was ≥130 ms and whose acute improvement in LV dyssynchrony was ≥33% was greater than that of the patients with baseline LV dyssynchrony of ≥130 ms but with acute improvement in LV dyssynchrony of <33% (88% vs 65%, p = 0.012). In conclusion, the combined assessment of baseline LV dyssynchrony and its acute improvement after CRT produced a more accurate prediction of long-term outcomes after CRT.2012年12月, The American journal of cardiology, 110(12) (12), 1814 - 9, 英語, 国際誌[査読有り]
- 2012年12月, Clinical Kidney Journal, 5(6) (6), 512 - 518研究論文（学術雑誌）
- 2012年12月, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 25(12) (12), 1299 - 1308, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: Regional heterogeneity of left ventricular (LV) contraction, known as dyssynergy, in idiopathic dilated cardiomyopathy (IDC) patients has been previously reported, but no comprehensive analysis of this abnormality has been made. The purpose of this study was to test the hypothesis that regional heterogeneity of systolic dysfunction is associated with LV dyssynchrony in IDC patients with a narrow QRS complex using novel three-dimensional (3D) speckle-tracking strain. METHODS: We studied 54 consecutive IDC patients with ejection fraction (EF) of 34 ± 12% and QRS duration of 102 ± 13 msec (all <120 msec), and 30 age-matched normal controls. The 3D speckle-tracking LV dyssynchrony (LV dyssynchrony index) was quantified from all 16 LV sites to determine the standard deviation (SD) of time-to-peak strain. Similarly, regional heterogeneity of LV systolic function (LV dyssynergy index) was quantified from all 16 LV sites to establish the SD of peak 3D speckle-tracking strain. RESULTS: The LV dyssynergy and dyssynchrony indices of IDC patients were significantly larger than those of normal controls. Furthermore, IDC patients showed significantly higher Z-scores for septum and inferior regions than for the free wall (3.34 ± 1.21 vs. 1.69 ± 1.06 and 2.79 ± 1.30 vs. 1.69 ± 1.06, respectively, P < 0.001). An important findings of multivariable analysis was that the LV dyssynergy index (β = 0.69, P < 0.001) and LVEF (β = -0.34, P = 0.001) were independent determinants of the LV dyssynchrony index. CONCLUSION: 3D speckle-tracking strain revealed that the myocardial systolic dysfunction of IDC patients with a narrow QRS complex has a marked heterogeneous regional distribution. This regional heterogeneity as well as systolic dysfunction is thought to lead to LV dyssynchrony.2012年11月, Echocardiography (Mount Kisco, N.Y.), 29(10) (10), 1201 - 10, 英語, 国際誌[査読有り]
- AIMS: Although right ventricular (RV) pacing has a detrimental effect on global left ventricular (LV) function even in some patients with preserved ejection fraction (EF), its mechanism remains unclear. METHODS AND RESULTS: We studied 116 subjects; 56 patients with RV pacing and preserved EF (all ≥50%), 30 EF-matched controls, and 30 heart failure (HF) patients with RV pacing and reduced EF (all ≤35%). Radial, circumferential, and longitudinal dyssynchrony and function were quantified as standard deviations of the time-to-peak strain and global peak strain from all 16 LV segments using three-dimensional (3D) speckle-tracking strain. The degree of radial and circumferential dyssynchrony and function were similar for patients with RV pacing and preserved EF and controls. However, patients with RV pacing and preserved EF showed a greater longitudinal dyssynchrony of 46 ± 14 vs. 31 ± 9 ms (P < 0.01) and lower global longitudinal strain at 25 ± 4 vs. 34 ± 7% compared with controls (P < 0.001). Furthermore, longitudinal strain at the apical level was significantly lower than that at the mid- and basal level (20 ± 4 vs. 27 ± 5 and 26 ± 5%, P < 0.001), and longitudinal dyssynchrony at the apical level was significantly larger than at the mid- and basal level (44 ± 19 vs. 36 ± 20 and 32 ± 15 ms, P < 0.05) in patients with RV pacing and preserved EF. In contrast, HF patients with RV pacing and reduced EF showed greater radial, circumferential, and longitudinal dyssynchrony, and lower global radial, circumferential, and longitudinal strain than did controls (all P < 0.001). CONCLUSION: Three-dimensional speckle-tracking strain was found to be useful for evaluating early subtle changes associated with chronic RV pacing, and may thus play a clinical role in predicting future global LV dysfunction.2012年10月, European heart journal cardiovascular Imaging, 13(10) (10), 849 - 56, 英語, 国際誌[査読有り]
- 2012年07月, Canadian Journal of Cardiology, 28(4) (4), 515.e3 - 515.e6[査読有り]研究論文（学術雑誌）
- BACKGROUND: The aim of this study was to test the hypothesis that patients with reverse-remodeled dilated cardiomyopathy (DCM), whose ejection fractions (EFs) were normalized after optimal pharmacologic therapy, had subclinical myocardial dysfunction. METHODS: Thirty-two patients with reverse-remodeled DCM, defined as having an initial EF ≤ 35%, which then recovered to ≥50% after optimal pharmacologic therapy, and 11 normal controls with preserved EFs were retrospectively studied. Averaged peak systolic and early diastolic radial, circumferential, and longitudinal speckle-tracking strain rates were assessed from an 18-segment left ventricular model. Similarly, averaged peak systolic radial, circumferential, and longitudinal speckle-tracking strain was obtained. RESULTS: Peak systolic and early diastolic longitudinal strain rates, peak systolic and early diastolic circumferential strain rates, and peak circumferential and longitudinal strain in patients with reverse-remodeled DCM were significantly lower than those in normal controls, but peak systolic and early diastolic radial strain rates and peak radial strain in patients with reverse-remodeled DCM were similar to those in normal controls. Isometric handgrip stress testing showed a significant decrease in EF from 56 ± 5% to 51 ± 5% (P < .001). Of note, the increase of afterload resulting from isometric handgrip stress testing was associated with a decrease in peak systolic circumferential and longitudinal strain rates and peak circumferential strain in patients with reverse-remodeled DCM. CONCLUSIONS: The circumferential and longitudinal myocardial function of patients with reverse-remodeled DCM is lower compared with that of normal controls with preserved EFs. Furthermore, the increase in afterload was associated with the decrease in circumferential and longitudinal myocardial systolic function. These findings suggest that in treated patients with DCM with reverse remodeling, left ventricular mechanics may not be normal, even when EFs are normal.2012年07月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 25(7) (7), 726 - 32, 英語, 国際誌[査読有り]
- 2012年06月, European heart journal cardiovascular Imaging, 13(6) (6), 531 - 531, 英語, 国際誌[査読有り]
- 2012年06月, CIRCULATION JOURNAL, 76(6) (6), 1399 - 1408, 英語[査読有り]研究論文（学術雑誌）
- <p>Background: The aim of this study was to predict left ventricular (LV) dysfunction and the timing to perform echocardiography in patients with Duchenne muscular dystrophy (DMD). We developed a scoring system using clinical parameters and examined its efficacy. It is indispensable to utilize echocardiogram for evaluating myocardial damage of DMD patients, but there is no established guideline for determining the clinical conditions which require echocardiographic examination. Methods: We retrospectively analyzed 86 patients with DMD who were treated in Kobe University Hospital from 2007 to 2009. The multiple logistic regression analysis on routine clinical data was performed to identify parameters that can find abnormal LV contraction, and to develop a weighted scoring system. Echocardiogram was performed as the gold standard for detecting LV dysfunction. Results: Four parameters were associated with abnormal LV contraction: (i) brain natriuretic peptide (BNP); (ii) creatine kinase; (iii) scoliosis; and (iv) body surface area. When BNP was used as the only predictor to evaluate LV systolic dysfunction, sensitivity and specificity were 36.4% and 92.1%, respectively. In contrast, a2012年06月, Pediatrics International, 54(3) (3), 388 - 392, 英語
- Strain dyssynchrony index (SDI), which was a marker of dyssynchrony and residual myocardial contractility, can predict left ventricular reverse remodeling short-term after cardiac resynchronization therapy (CRT). We investigated SDI-predicted long-term outcome after CRT in patients with heart failure (HF). We studied 74 patients with HF who underwent CRT. SDI was calculated as the average difference between peak and end-systolic strain from 6 segments for radial and circumferential SDIs and 18 segments for longitudinal SDI using 2-dimensional speckle-tracking strain. Based on our previous findings, the predefined cutoff for significant dyssynchrony and residual myocardial contractility was a radial SDI ≥6.5%, a circumferential SDI ≥3.2%, and a longitudinal SDI ≥3.6%. The predefined principal outcome variable was the combined end point of death or hospitalization owing to deteriorating HF. Long-term follow-up after CRT was tracked over 4 years. The primary end point of prespecified events occurred in 14 patients (19%). An association with a favorable long-term outcome after CRT was observed in patients with significant radial, circumferential, and longitudinal SDIs (p <0.001, <0.005, and 0.010 vs patients without significant SDIs, respectively). Furthermore, cardiovascular event-free rate after CRT in patients with positivity of 3 for the 3 SDIs was 100% better than that in patients with positivity of 1 (52%, p <0.005) or 0 (31%, p <0.001) for the 3 SDIs. In conclusion, SDIs can successfully predict long-term outcome after CRT in patients with HF. Moreover, the approach combining the 3 types of SDI leads to a more accurate prediction than the use of individual parameters. These findings may have clinical implications in patients with CRT.2012年04月, The American journal of cardiology, 109(8) (8), 1187 - 93, 英語, 国際誌[査読有り]
- 2012年04月, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 29(4) (4), 411 - 418, 英語[査読有り]研究論文（学術雑誌）
- 2012年04月, AMERICAN JOURNAL OF CARDIOLOGY, 109(8) (8), 1197 - 1205, 英語[査読有り]研究論文（学術雑誌）
- 2012年03月, Journal of echocardiography, 10(1) (1), 35 - 7, 英語, 国内誌[査読有り]
- 2012年03月, CIRCULATION JOURNAL, 76(3) (3), 744-751
- Prevalence and distribution of sarcomeric gene mutations in Japanese patients with familial hypertrophic cardiomyopathy.BACKGROUND: Hypertrophic cardiomyopathy (HCM), which is inherited as an autosomal dominant trait, is the most prevalent hereditary cardiac disease. Although there are several reports on the systematic screening of mutations in the disease-causing genes in European and American populations, only limited information is available for Asian populations, including Japanese. METHODS AND RESULTS: Genetic screening of disease-associated mutations in 8 genes for sarcomeric proteins, MYH7, MYBPC3, MYL2, MYL3, TNNT2, TNNI3, TPM1, and ACTC, was performed by direct sequencing in 112 unrelated Japanese proband patients with familial HCM; 37 different mutations, including 13 novel ones in 5 genes, MYH7, MYBPC3, TNNT2, TNNI3, and TPM1, were identified in 49 (43.8%) patients. Among them, 3 carried compound heterozygous mutations in MYBPC3 or TNNT2. The frequency of patients carrying the MYBPC3, MYH7, and TNNT2 mutations were 19.6%, 10.7%, and 8.9%, respectively, and the most frequently affected genes in the northeastern and southwestern parts of Japan were MYBPC3 and MYH7, respectively. Several mutations were found in multiple unrelated proband patients, for which the geographic distribution suggested founder effects of the mutations. CONCLUSIONS: This study demonstrated the frequency and distribution of mutations in a large cohort of familial HCM in Japan.2012年, Circulation journal : official journal of the Japanese Circulation Society, 76(2) (2), 453 - 61, 英語, 国内誌研究論文（学術雑誌）
- Effect of left ventricular dyssynchrony on cardiac sympathetic activity in heart failure patients with wide QRS duration.BACKGROUND: Dyssynchrony has various detrimental effects on cardiac function, but its effect on cardiac sympathetic activity is not fully understood. METHODS AND RESULTS: We studied 50 heart failure patients who underwent cardiac resynchronization therapy (CRT). Cardiac sympathetic activity was assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy as the delayed heart-to-mediastinum ratio (H/M ratio). Echocardiography was performed before and 7 months after CRT, and response was defined as a ≥15% decrease in end-systolic volume. Dyssynchrony was determined by the time difference between the anteroseptal-to-posterior wall using speckle-tracking radial strain (≥130 ms predefined as significant). H/M ratio in patients with dyssynchrony was less than that in patients without dyssynchrony (1.62 ± 0.31 vs. 1.82 ± 0.36, P<0.05), even though ejection fraction was not significantly different (24 ± 6% vs. 25 ± 7%). Patients with dyssynchrony and H/M ratio ≥1.6 had a higher frequency of response to CRT (94%) and favorable long-term outcome over 3.0 years. In contrast, patients without dyssynchrony and H/M ratio <1.6 were more likely to show a lower frequency of response to CRT (0%) and unfavorable long-term outcome after CRT. CONCLUSIONS: Dyssynchrony is associated with cardiac sympathetic activity, and (123)I-MIBG scintigraphy may be valuable for predicting the response to CRT.2012年, Circulation journal : official journal of the Japanese Circulation Society, 76(2) (2), 382 - 9, 英語, 国内誌[査読有り]
- Differences in hemodynamic parameters and exercise capacity between patients with pulmonary arterial hypertension and chronic heart failure., , , Kinutani H, , , Toh R, Miura Y, Sakai Y, Emoto N, Kawai H, Hirata K.2012年, J Cardiopulm Rehabil Prev, 32(6) (6), 379 - 385, 英語[査読有り]研究論文（学術雑誌）
- The presence of functional mitral regurgitation (MR) is considered a significant risk factor for poor clinical prognosis in patients with idiopathic dilated cardiomyopathy (IDC). The objectives of this study were to test the hypothesis that not only global but also local left ventricular (LV) remodeling, including the position of the papillary muscles, may contribute to the development of MR in patients with IDC and wide QRS durations and can be reversed with cardiac resynchronization therapy (CRT). Eighty-four subjects were studied, 44 patients with IDC who underwent CRT and 40 age- and gender-matched controls. The position of the posteromedial papillary muscle was similar in the 2 groups, whereas the position of the anterolateral papillary muscle in patients with IDC was displaced more posteriorly than in controls. Multivariate analysis revealed that reduction in coaptation height (β = 0.44, p <0.001) and LV dyssynchrony by speckle-tracking radial strain (β = 0.303, p <0.01) were independent determinants of reduction in MR 5 ± 2 days after CRT; in contrast, restoration of the position of the posteriorly displaced anterolateral papillary muscle (β = 0.50, p <0.001) and the increase in sphericity index (β = 0.440, p <0.001) were identified as independent determinants of reduction in MR 6 ± 1 months after CRT. In conclusion, asymmetric local LV remodeling was observed at baseline, and asymmetric local LV reverse remodeling was observed at long-term follow-up after CRT in patients with IDC. Furthermore, different parameters contribute to the reduction in MR observed at short- and long-term follow-up after CRT.2011年11月, The American journal of cardiology, 108(9) (9), 1327 - 34, 英語, 国際誌[査読有り]
- 2011年10月, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 24(10) (10), 1101 - 1108, 英語[査読有り]研究論文（学術雑誌）
- <p>Aims: Cardiac resynchronization therapy (CRT) can stop the vicious cycle resulting from dyssynchrony and generates left ventricular (LV) reverse remodelling. Our objective was to assess the time course and the relationship between improvement in LV dyssynchrony and reverse remodelling after CRT. Methods and results: Sixty-four consecutive patients were evaluated before, immediately after, and 3- and 6 months after CRT. We measured LV volumes, ejection fraction (EF), and sphericity index, and dyssynchrony was assessed using speckletracking radial strain. Response was defined as a >15% decrease in end-systolic volume (ESV) 6 months after CRT, and event-free survival was followed for 24 months. Responders and non-responders had similar baseline LV volumes and EF. During the first and the following 3 months after CRT, LV volumes gradually decreased (enddiastolic volume: 195±73 to 164+60* to 129±51 mL†, ESV: 141±70 to 110±47* to 82±40 mL†), and sphericity index and EF progressively increased (sphericity index: 1.52±0.20 to 1.75±0.31* to 1.94±0.34†, EF: 28±7 to 34±7* to 38±8%†, *†P < 0.001) in responders. No such changes were observed in non-responders. Furt2011年10月, European Journal of Echocardiography, 12(10) (10), 782 - 789, 英語
- 2011年09月, Echocardiography (Mount Kisco, N.Y.), 28(8) (8), E172-3, 英語, 国際誌[査読有り]
- 2011年09月, AMERICAN JOURNAL OF CARDIOLOGY, 108(6) (6), 867 - 872, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: We have previously reported strain dyssynchrony index assessed by two-dimensional speckle tracking strain, and a marker of both dyssynchrony and residual myocardial contractility, can predict response to cardiac resynchronization therapy (CRT). A newly developed three-dimensional (3-D) speckle tracking system can quantify endocardial area change ratio (area strain), which coupled with the factors of both longitudinal and circumferential strain, from all 16 standard left ventricular (LV) segments using complete 3-D pyramidal datasets. Our objective was to test the hypothesis that strain dyssynchrony index using area tracking (ASDI) can quantify dyssynchrony and predict response to CRT. METHODS: We studied 14 heart failure patients with ejection fraction of 27 ± 7% (all≤35%) and QRS duration of 172 ± 30 ms (all≥120 ms) who underwent CRT. Echocardiography was performed before and 6-month after CRT. ASDI was calculated as the average difference between peak and end-systolic area strain of LV endocardium obtained from 3-D speckle tracking imaging using 16 segments. Conventional dyssynchrony measures were assessed by interventricular mechanical delay, Yu Index, and two-dimensional radial dyssynchrony by speckle-tracking strain. Response was defined as a ≥15% decrease in LV end-systolic volume 6-month after CRT. RESULTS: ASDI ≥ 3.8% was the best predictor of response to CRT with a sensitivity of 78%, specificity of 100% and area under the curve (AUC) of 0.93 (p < 0.001). Two-dimensional radial dyssynchrony determined by speckle-tracking strain was also predictive of response to CRT with an AUC of 0.82 (p < 0.005). Interestingly, ASDI ≥ 3.8% was associated with the highest incidence of echocardiographic improvement after CRT with a response rate of 100% (7/7), and baseline ASDI correlated with reduction of LV end-systolic volume following CRT (r = 0.80, p < 0.001). CONCLUSIONS: ASDI can predict responders and LV reverse remodeling following CRT. This novel index using the 3-D speckle tracking system, which shows circumferential and longitudinal LV dyssynchrony and residual endocardial contractility, may thus have clinical significance for CRT patients.2011年04月, Cardiovascular ultrasound, 9, 11 - 11, 英語, 国際誌[査読有り]
- AIMS: The aim of this study was to test the hypothesis that, unlike calculation of the mitral valve area (MVA) with the pressure half-time method (PHT), the proximal isovelocity surface area method (PISA) is not affected by changes in net atrioventricular compliance (C(n)). METHODS AND RESULTS: We studied 51 patients with mitral stenosis (MS) from two centres. MVA was assessed with the PISA (MVA(PISA)), PHT (MVA(PHT)), and planimetry (MVA(PLN), serving as the gold standard) method. C(n) was calculated with a previously validated equation using 2D echocardiography. MVA(PISA) closely correlated with MVA(PLN) (r = 0.96, P < 0.0001), while MVA(PHT) and MVA(PLN) showed a weaker but still good correlation (r = 0.69, P < 0.0001). The correlation between MVA(PHT) and MVA(PLN) for patients with C(n) between 4 and 6 mL/mmHg (considered to be normal) was excellent (r = 0.93, P < 0.0001), but that for patients with C(n) of less than 4 or more than 6 mL/mmHg was not as good (r = 0.64, P < 0.0001). Importantly, a significant inverse correlation was detected between the percentage difference among MVA(PHT), MVA(PLN), and C(n) (r = -0.77, P < 0.0001), but the line of fit was nearly flat for the percentage difference among MVA(PISA), MVA(PLN), and C(n) (r = 0.1, P = 0.388). CONCLUSION: MVA calculated with both the PISA and PHT methods correlated well with MVA calculated with the planimetry method. However, the PISA rather than PHT is recommended for patients with MS and extreme C(n) values because PISA, unlike PHT, is not affected by changes in C(n).2011年04月, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 12(4) (4), 283 - 90, 英語, 国際誌[査読有り]
- A 53-year-old man with depressed ejection fraction (EF) of 35% and QRS width of 88 ms at rest was admitted to our institution with a complaint of exertional chest discomfort and dyspnea. During treadmill exercise, left bundle-branch block (LBBB) with a QRS width of 152 ms occurred at a heart rate of 100 bpm. During LBBB, the patient showed significant mechanical dyssynchrony as evidenced by a two-dimensional speckle tracking radial strain of 260 ms (≥ 130 ms), defined as the time difference between anterior-septum and posterior wall. Five-month after carvedilol and candesartan administration, EF had improved to 49% and LBBB did not occur until a heart rate of 126 bpm was attained during treadmill exercise. It appears that pharmacological therapy may be useful for patients with heart failure and exercise-induced LBBB.2011年02月, Cardiovascular ultrasound, 9(1) (1), 4 - 4, 英語, 国際誌[査読有り]
- 2011年02月, CARDIOVASCULAR ULTRASOUND, 9, 8, 英語[査読有り]研究論文（学術雑誌）
- 2011年02月, AMERICAN JOURNAL OF CARDIOLOGY, 107(3) (3), 439 - 446, 英語[査読有り]研究論文（学術雑誌）
- We report the extremely rare case of a 73-year-old asymptomatic patient who has an isolated true parachute mitral valve (PMV). In the echocardiographic examination, the parasternal long-axis view showed a single papillary muscle. The short-axis view revealed the presence of a symmetric mitral valve orifice with all chordae attaching to a large anterolateral papillary muscle. Because detailed examination did not reveal the presence of other complications, this patient was diagnosed as an isolated true PMV.2010年12月, Journal of echocardiography, 8(4) (4), 131 - 2, 英語, 国内誌[査読有り]
- <p>Background - Left ventricular (LV) remodeling can increase tethering force to mitral valve and functional mitral regurgitation (FMR). Because the relationship between FMR and regional myocardial function has not been quantitatively evaluated, we conducted a quantitative investigation of this association. Methods and Results-The effective regurgitant orifice (ERO) of FMR in 51 patients with depressed LV ejection fraction (32±9%) secondary to ischemic or nonischemic cardiomyopathy was compared with mitral deformation (valve and annulus), global LV remodeling (volume indices, function, and sphericity), and regional myocardial contractile function, as assessed by longitudinal peak systolic strain rate (Ssr) in LV anterior, anteroseptal, inferoseptal, inferior, inferolateral, and anterolateral segments at rest. Low-dose dobutamine (10 μg/kg per minute)-induced changes in ERO were compared with changes in the variables. Multivariable analysis identified the predictors of ERO at rest as mitral valvular tenting (β=0.062; P<0.001), Ssr in the inferior segment (inferior Ssr) (β=-0.178; P<';.001), and LV sphericity (β=0.414; P=0.001) and the predictors of valvular tenting at res2010年11月, Circulation: Cardiovascular Imaging, 3(6) (6), 638 - 646, 英語
- 2010年10月, CIRCULATION, 122(16) (16), E488 - E490, 英語[査読有り]
- A 78-year-old woman presented with leg edema and exertional dyspnea. Echocardiography revealed a smooth-surfaced mass adjacent to the left atrium in the pericardial cavity with a massive pericardial effusion. Pericardiocentesis resulted in the drainage of a bloody effusion. Magnetic resonance imaging documented a mass having isointensity on T1- and hyperintensity on T2-weighted images. In addition, the mass was evenly enhanced with gadolinium 10 min after administration. By surgical resection, a 25 × 30 mm in diameter tumor was excised together with a left atrial wall portion. The pathological examination made a final diagnosis as hemangioma. Based on these findings, we report the rare case of pericardial hemangioma with a bloody pericardial effusion, which presented with heart failure symptoms. Although bloody pericardial effusion is considered a supportive characteristic for malignant tumors, we could preoperatively make a precise diagnosis of benign hemangioma by means of several imaging modalities.2010年08月, Journal of cardiology cases, 2(1) (1), e15-e19, 英語, 国内誌[査読有り]
- 2010年06月, ANNALS OF NUCLEAR MEDICINE, 24(5) (5), 379 - 385, 英語[査読有り]研究論文（学術雑誌）
- <p>Background-The best predictor for postoperative left ventricular (LV) systolic dysfunction in patients with chronic aortic regurgitation is still a matter of debate. The aim of this study was to assess the clinical significance of preoperative systolic radial strain rate (Ssr) derived from tissue Doppler echocardiography as a predictor of postoperative LV systolic dysfunction in patients with chronic aortic regurgitation. Methods and Results-In 52 patients (mean age, 58 years; 13 women) with isolated chronic aortic regurgitation, we performed standard and tissue Doppler echocardiography before and after operation, obtained echocardiographic parameters such as LV dimensions and LV ejection fraction, and measured Ssr in 4 walls of the LV. Linear regression analysis determined correlations between preoperative parameters and postoperative LV ejection fraction. Receiver-operating characteristic curve analysis assessed the optimal cutoff values of parameters that predicted postoperative LV systolic dysfunction (ejection fraction <50%). The operation caused significant decreases in LV dimensions and volumes and significant increases in Ssr (1.94±0.64 to 2.39±0.83 per second; P<2010年03月, Circulation: Cardiovascular Imaging, 3(2) (2), 134 - 141, 英語
- 2010年02月, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 23(2) (2), 181 - 189, 英語[査読有り]研究論文（学術雑誌）
- Japan Heart Foundation, 2010年, 心臓, 42(7) (7), 919 - 920, 日本語
- 2009年12月, ANNALS OF NUCLEAR MEDICINE, 23(10) (10), 863 - 868, 英語[査読有り]研究論文（学術雑誌）
- 2009年11月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 30(5) (5), 973 - 980, 英語[査読有り]研究論文（学術雑誌）
- 2009年10月, EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 10(7) (7), 889 - 892, 英語[査読有り]研究論文（学術雑誌）
- 2009年08月, JOURNAL OF CARDIOLOGY, 54(1) (1), 139 - 143, 英語[査読有り]研究論文（学術雑誌）
- 2009年05月, Therapeutic Research, 30巻, 5号, pp. 577-580, 日本語治療法の選択に苦慮した重症肺血栓塞栓症の1例[査読有り]研究論文（研究会，シンポジウム資料等）
- 2009年05月, Therapeutic Research, 30巻, 5号, pp. 712-714, 日本語一時的下大静脈フィルターが血栓閉塞し抜去に苦慮した先天性凝固異常合併、妊娠初期深部静脈血栓症の2例[査読有り]研究論文（研究会，シンポジウム資料等）
- 2009年, Kobe Journal of Medical Sciences, 55(1) (1), E16 - E29, 英語Value of convex-type ST-segment elevation and abnormal Q waves for electrocardiographic-based identification of left ventricular remodeling in hypertrophic cardiomyopathy[査読有り]研究論文（学術雑誌）
- 2009年, AMERICAN JOURNAL OF NEPHROLOGY, 30(6) (6), 527 - 535, 英語[査読有り]研究論文（学術雑誌）
- 2008年10月, 日本内科学会雑誌, 97巻, 10号, pp. 2549-2551, 日本語エンドセリン受容体拮抗薬が著効した心房中隔欠損症に伴うEisenmenger症候群の1例[査読有り]研究論文（学術雑誌）
- The relationship between baroreceptor sensitivity (BRS) and cardiac sympathetic nerve function after acute myocardial infarction (AMI) was investigated in 34 patients. BRS was measured during the Valsalva maneuver and cardiac sympathetic function was assessed by the washout rate (WR) of I-123 meta-iodo-benzyl guanidine (123I-MIBG) with planar image (global WR) and polar map analysis (regional WR). Gated left ventricular ejection fraction (LVEF) measured by left ventriculography as a parameter of ventricular function was measured with quantitative gated SPECT (QGS). The gated LVEF correlated with global WR (r=-0.36, p=0.034) and regional WR of normal area (r=-0.46, p=0.006), but not with BRS, although BRS correlated with global WR (r=-0.43, p=0.015) and regional WR of normal area (r=-0.72, p<0.0001). After AMI, baroreceptor function is linked to sympathetic activation, as elucidated by the regional WR of normal area, which suggests that separation of the infarcted area from the non-infarcted myocardium is necessary for evaluating sympathetic activation after AMI and that the regional kinetics of 123I-MIBG in the normal area are a more suitable marker of activated cardiac nerve function than global 123I-MIBG kinetics. (Circ J 2002; 66: 247 - 252)社団法人日本循環器学会, 2002年02月, Circulation journal : official journal of the Japanese Circulation Society, 66(3) (3), 247 - 252, 英語
- Beta-blocker therapy has been shown to improve cardiac function and prognosis in patients with idiopathic dilated cardiomyopathy (DCM). However, whether β-blockers reduce severe ventricular arrhythmias and sudden cardiac death has not been clarified. The present study was designed to investigate the effects of β-blockers on non-sustained ventricular tachycardia (VT) and sudden cardiac death in patients with DCM. Sixty-five patients with DCM treated with diuretics, digitalis and angiotensin-converting enzyme inhibitors were assigned to receive β-blockers (n=33) or not (n=32). Mean follow-up was 53±30 months. The echocardiographic indices of cardiac function, the incidence of non-sustained VT on Holter monitoring electrocardiograms, and sudden cardiac death rate were compared between the 2 groups. Comparable improvement in cardiac function on echocardiograms was found in the 2 treatment groups. The patient group treated with β-blockers showed a significant reduction in the prevalence of VT (from 43 to 15%, p<0.05) and the development of new episodes of VT (5 vs 16%) compared to the group without β-blockers. The sudden cardiac death rate did not differ between the 2 groups. The results of the present study suggest that β-blockers are effective in reducing severe ventricular arrhythmias in patients with DCM.社団法人日本循環器学会, 2000年01月, Japanese circulation journal, 64(2) (2), 87 - 92, 英語
- 1995年03月, Journal of cardiology, 25, 49 - 50, 日本語肥大型心筋症の頻拍時心予備能
- 1995年03月, Journal of cardiology, 25, 59 - 61, 日本語拡張型心筋症の予後に対する血管拡張薬療法の有用性
- 1995年01月, Journal of cardiology, 25(1) (1), 23 - 28, 日本語僧帽弁狭窄症における肺静脈血流速波形の検討
- The effect of recent advances in pharmacologic management on the prognosis of dilated cardiomyopathyTo determine the effect of recent advances in medical management on the survival of patients with dilated cardiomyopathy (DCM), 103 patients with DCM were studied. The subjects were divided into 3 groups based upon the time of initial medical treatment at our institute: Group I, between 1976 and 1981, 20 patients; Group II, between 1982 and 1985, 27 patients; and Group III, between 1986 and 1991, 56 patients. The clinical, Holter electrocardiographic and echocardiographic findings, the pharmacologic treatments used, and the clinical outcomes for the 3 groups of patients were compared. During the follow-up period, which averaged 27 months, 31 deaths related to cardiac disease occurred. The 4 year survival rate was 76% in Group III, 49% in Group II and 35% in Group I; the difference in survival rate between Groups I and III was significant (p<0.01). At the initial evaluation, no differences were found among the 3 groups in the incidences of advanced heart failure (NYHA functional class III or IV), atrial fibrillation or complex ventricular arrhythmias. Neither diastolic blood pressure nor heart rate differed among the 3 groups, but Group III patients were older and had significantly higher systolic blood pressures than Group I patients (p<0.05, for both comparisons). There were no differences among the 3 groups in % fractional shortening, left ventricular end-systolic wall stress or left ventricular wall thickness, but left ventricular dimensions were significantly smaller in Group III than in Group I (p<0.05). Digitalis and/or diuretic agents were administered to all of the patients of Groups I and II and to most of the patients of Group III. There were no differences among the 3 groups in the number of patients who received antiarrhythmics or anticoagulants, but vasodilators and β-blockers were used more frequently in Group III than in Groups I and II (p<0.01 for each comparison). In conclusion, the prognosis of DCM has improved, and various factors, including recent advances in pharmacologic treatments, have contributed to the prolongation of life for patients with DCM.社団法人日本循環器学会, 1993年, Jpn Circ J, 57, 1038 - 1046, 英語
- 社団法人日本循環器学会, 1993年, Jpn Circ J, 57, 1379 - 1382, 日本語慢性心不全の治療 : β遮断薬
- 拡張型心筋症(DCM)における突然死例の臨床ならびに病理組織学的特徴を明らかにするため,当施設にてDCMと診断され,経過観察中に突然死した16例(SD群)の臨床ならびに病理組織所見を心不全死した49例(CHF群)と対比しつつ検討した.公益財団法人 日本心臓財団, 1992年, 心臓, 24(5) (5), 48 - 53, 日本語
【結果】( 1 ) 初診時のN Y H A 心機能分類重症度III・IV度の症例はCHF群に比しSD群で有意に低頻度であったが,両群の年齢,性,血圧,心拍数,経過観察期間,軽症高血圧歴および中等量飲酒歴の頻度には差を認めなかった.(2)初診時胸部X線上の心胸郭比,12誘導ならびにホルター心電図所見,心エコーならびに心臓カテーテル検査指標は両群間で有意差を示さず,両群の右室心筋生検所見(心筋肥大,線維化,心筋変性,配列の乱れ)にも差がなかった.(3)剖検所見では心重量,心筋平均横径,線維化率,変性の程度には差を認めなかったが,CHF群に比しSD群には中等以上の細胞浸潤および配列の乱れが高頻度に観察され,病理組織学的に心筋炎の関与が示唆される症例が高頻度に含まれていた.
【結語】DCM症例,特に突然死例には心筋炎が関与する症例が高頻度に含まれている可能性が示唆された. - Japanese Circulation Society, 1991年04月, Japanese Circulation Journal, 55(4) (4), 343 - 355研究論文（学術雑誌）
- 2025年, 日本肺高血圧・肺循環学会学術集会抄録集(Web), 10th肺動脈楔入圧の代用として拡張期肺動脈圧の可能性の検討
- 2025年, 日本循環器学会学術集会(Web), 89thLBBB,右室ペーシングおよび非LBBB患者における心同期療法に対する反応の比較分析【JST機械翻訳】|||
- 2025年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2025右冠尖・左冠尖間のマイクロ電極でのみ記録できた電位が心室頻拍の必須緩徐伝導路と考えられた拡張型心筋症の1例
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- 2025年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2025冠静脈とMarshall静脈の電位がSplitしており頻拍回路の同定に有用であったPerimitral ATの2症例
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- 2024年, 日本循環器学会学術集会(Web), 88thMitraClip後の予後に対する残留僧帽弁逆流症と狭窄症の影響
- 2024年, 日本循環器学会学術集会(Web), 88thSFA-CTOに対するEVTのMR検出高度プラークの影響
- 2024年, 日本循環器学会学術集会(Web), 88th大血管de-novo病変またはステント内再狭窄に対する薬物コーティングバルーンの長期心血管転帰
- 2024年, 日本循環器学会学術集会(Web), 88thECPR実施施設における非バイスタンダーCPRの因子と予後的影響
- 2024年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2024複数の心室頻拍の回路を形成する多数のLate Potentialに対してLate Annotation Mappingを用いてScar Dechannelingできた陳旧性心筋梗塞の1例
- 2024年, 核医学(Web), 61(Supplement) (Supplement)肺疾患を合併した肺動脈性肺高血圧症の治療効果を換気血流シンチから検討する
- 2024年, 日本心臓病学会学術集会(Web), 72nd循環器医は全身性アミロイドーシスをどのように診断していくか
- 2024年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2024LV summit領域に必須緩徐伝導路を有する心室頻拍に対して心内膜側から焼灼しえたMitraClip後の拡張型心筋症の1例
- 2024年, 日本肺高血圧・肺循環学会学術集会抄録集(Web), 9th (CD-ROM)吸引細胞診と剖検により診断に至ったPTTMの一例
- 2024年, 日本肺高血圧・肺循環学会学術集会抄録集(Web), 9th (CD-ROM)肺高血圧症の早期診断:多専門科連携による息切れ外来の取り組み
- 2023年, 日本循環器学会学術集会(Web), 87th超高齢心房細動患者におけるカテーテルアブレーションの有効性と安全性
- 2023年, 日本循環器学会学術集会(Web), 87th経カテーテル大動脈弁置換術後の機能的僧帽弁逆流症患者における心血管イベントに対する残存肺高血圧症の影響
- 2023年, 日本循環器学会学術集会(Web), 87th経カテーテル僧帽弁形成術を受けた非虚血性心筋症患者におけるネイティブT1マッピングの有効性
- 2023年, 日本循環器学会学術集会(Web), 87th心原性ショックを伴う急性心不全患者におけるIMPELLAの有用性の評価
- 2023年, 日本肺高血圧・肺循環学会学術集会抄録集(Web), 8th気腫合併肺線維症と心不全よりPHを呈した症例の治療
- 2023年, 日本肺高血圧・肺循環学会学術集会抄録集(Web), 8th肺高血圧症が初発症状であった高安動脈炎の一例
- 2023年, 日本心臓病学会学術集会(Web), 71st当院の息切れ外来について
- 2023年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2023多形性心室頻拍に対しIMPELLA留置下にカテーテルアブレーションを施行した亜急性心筋梗塞の1例
- 2023年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2023右肺静脈分岐部と右房後壁にepicardial connectionを認め,右房後壁の通電で肺静脈隔離を得られた1例
- 2023年, 日本腫瘍循環器学会学術集会抄録集(Web), 6th最終的に腎盂がんの診断に至ったトルソー症候群の一例
- 2023年, 日本腫瘍循環器学会学術集会抄録集(Web), 6th多彩な病態を呈した癌治療関連心・肺障害の1例
- 2022年, 植込みデバイス関連冬季大会プログラム・抄録集(Web), 14th三尖弁置換術後の心室リード断線に対して冠静脈に心室リード留置を行なった徐脈性心房細動の1例
- 2022年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022冠静脈・Marshall静脈と左房の伝導が左心耳側で離断されることで治療しえたPerimitralATの1例
- 2022年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022心房細動に対するカテーテルアブレーション後,難治性下痢をきたした1例
- 2022年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022心房中隔切開アプローチによる僧帽弁形成術後に認めた心房頻拍に対して,複数の線状焼灼を要した1例
- 2022年, 日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2022左冠動脈回旋枝-冠静脈瘻に伴う瘤状化した冠静脈内に認めたLocalized-reentrant ATの1例
- 2022年, 日本循環器学会学術集会(Web), 86th慢性心不全症例へのイバブラジン導入における循環器指標の変化と問題点
- 2022年, 日本循環器学会学術集会(Web), 86th難治性重症心不全患者に対する日帰りドブタミン静注療法に関する検討~QOLが保持できた事例~
- 2022年, 日本循環器学会学術集会(Web), 86th大動脈Stenosis患者における経皮的冠動脈インターベンション前および併用経カテーテル大動脈弁置換術の安全性と実現可能性【JST・京大機械翻訳】|||
- 2022年, 日本循環器学会学術集会(Web), 86th当院における慢性心不全患者に対するサクビトリルバルサルタン使用状況について
- 2022年, 超音波医学 Supplement, 49経皮的僧帽弁修復術後の中隔穿刺部位に血栓を認めた一例
- 2021年, 日本心臓病学会学術集会(Web), 69th拡大肺静脈隔離後に一方向性の肺静脈-左房伝導ブロックを認めた薬剤抵抗性症候性持続性心房細動の一例
- 2021年, 日本心臓病学会学術集会(Web), 69th補助循環用ポンプカテーテル(IMPELLA)補助により救命し得た急性心筋梗塞に伴う心室中隔穿孔による心原性ショックの一例
- 2021年, 日本心臓病学会学術集会(Web), 69thImpella CPの刺入部出血に対しての16Frシース使用の有用性検討
- 2021年, 日本循環器学会学術集会(Web), 85thCMRマッピングとPYPシンチグラフィーによる心臓アミロイドーシスの有用な管理【JST・京大機械翻訳】|||
- 2021年, 日本循環器学会学術集会(Web), 85thストレスタリウム-201心筋シンチグラフィーを用いた血管造影多枝冠動脈疾患患者におけるウォッシュアウト率の評価【JST・京大機械翻訳】|||
- 2021年, 日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集, 2021 (Web)communicating vein内で認めたQRSに先行する電位記録部位を解剖学的指標として通電を行うことで治療に成功したLV summit起源心室期外収縮の2症例
- 2021年, 日本冠疾患学会誌(Web), (Supplement) (Supplement)虚血性心疾患に合併した僧帽弁閉鎖不全症の診断と治療のための心エコー図
- 2020年, 心臓核医学, 22(2) (2)CTO病変に対する負荷心筋シンチグラフィでの虚血評価の検討
- 2020年, 心臓核医学, 22(2) (2)半導体D SPECTで心アミロイドーシスを診断する
- 2020年, 日本循環器学会学術集会(Web), 84th急性非代償性心不全患者におけるコラーゲンIV型の予後的価値【JST・京大機械翻訳】|||
- 2019年, 心臓核医学, 21(2) (2)半導体D SPECTでの99mTc-tetrofosminと123I-BMIPPによる二核種同時収集の検討
- 2019年, 日本心臓病学会学術集会(Web), 67th心サルコイドーシスをマッピングで診る
- 2019年, 日本心臓病学会学術集会(Web), 67th心肺停止で初診来院したBrugada症候群の一例
- 2019年, 日本心臓病学会学術集会(Web), 67th急性心筋炎様病態で発症した褐色細胞腫の一例
- 2019年, 心臓核医学, 21(2) (2)Cardio REPOのANN解析による虚血性心疾患診断と予後評価
- 2019年, 核医学(Web), 56(Supplement) (Supplement)半導体D SPECTでのBMIPP/Tc二核種同時収集を直接比較法(ISCH)法で検討する
- 2019年, 日本循環器学会学術集会(Web), 83rd左室機能不全患者に対する心房細動のカテーテルアブレーションの影響【JST・京大機械翻訳】|||
- 2019年, 日本循環器学会学術集会(Web), 83rd多枝冠動脈疾患患者のストレスタリウム-201CZT心筋シンチグラフィーにおけるウォッシュアウト率とTID分析の評価【JST・京大機械翻訳】|||
- 2019年, 日本循環器学会学術集会(Web), 83rd心房細動に対するホットバルーンアブレーションの周術期期間中における無症候性脳塞栓症の発生率【JST・京大機械翻訳】|||
- 2018年, 心臓核医学, 20(2) (2)心臓限局性サルコイドーシス診断における核医学検査の役割
- 2018年, 心臓核医学, 20(2) (2)負荷タリウム心筋シンチによるTIDとWashout Rateを用いた多枝冠動脈虚血病変の検出の検討
- 2018年, 心臓核医学, 20(2) (2)高度大動脈弁狭窄症における左室後負荷指標と心臓交感神経活性の関係
- 2018年, 日本循環器学会近畿地方会(Web), 126th右心系感染性心内膜炎疑いで紹介された一例
- 2018年, 日本心臓病学会学術集会(Web), 66th心臓MRIを用いた当院での心サルコイドーシス診断プロセスの検討
- 2018年, 日本循環器学会近畿地方会(Web), 126th高ホモシステイン血症により肺血栓塞栓症を来した1例
- 2018年, 日本循環器学会近畿地方会(Web), 126thDCMに伴うsevere functional MRに対して2clipによりMRの制御が可能であった1症例
- 2018年, 核医学(Web), 55(Supplement) (Supplement)心疾患診断における半導体ガンマカメラでの123Iと99mTc二核種同時収集の有用性
- 2018年, 日本循環器学会学術集会(Web), 82nd信号平均心電図における磁気共鳴画像と心室遅延電位の遅延増強の分布間の関係【JST・京大機械翻訳】|||
- 2018年, 日本循環器学会学術集会(Web), 82nd姿勢変化時の心拍変動のパワースペクトル解析は運動耐性と心不全入院を予測する【JST・京大機械翻訳】|||
- 2018年, 日本循環器学会学術集会(Web), 82nd難治性心不全患者に対するサポート的・緩和ケアチームの構築と実践【JST・京大機械翻訳】|||
- 2017年, 心臓核医学, 19(2) (2)D-SPECTでの99mTcと123Iによる心筋2核種同時収集の臨床応用を検討する
- 2017年, 日本循環器学会近畿地方会(Web), 123rd心臓MRIで特発性心筋炎の経過を観察し得た1例
- 2017年, 日本循環器学会近畿地方会(Web), 124th心肺停止状態で救急搬送され,皮下植込み型除細動器の植込みを行ったBrugada症候群の一例
- 2017年, 日本循環器学会近畿地方会(Web), 124th末端肥大症を合併した肥大型心筋症の2症例
- 2017年, 日本循環器学会近畿地方会(Web), 124th心膜液貯留が診断の契機となった好酸球性多発血管炎性肉芽腫症の1例
- 2017年, 日本循環器学会学術集会(Web), 81st電気解剖学的マッピングの統合のための磁気共鳴イメージングの有用性【JST・京大機械翻訳】|||
- 2017年, 日本循環器学会学術集会(Web), 81stリソリュートゾタロリムス溶出ステントを移植した患者におけるプラスグレル単独療法後の1か月二重抗血小板療法の安全性の評価【JST・京大機械翻訳】|||
- 2016年11月, CIRCULATION, 134, 英語Relationship Between Left Ventricular Diastolic Function and Cardiac Sympathetic Nerve Activity in Heart Failure Patients With Reduced and Preserved Ejection Fraction研究発表ペーパー・要旨（国際会議）
- (一社)日本心臓病学会, 2016年09月, 日本心臓病学会学術集会抄録, 64回, P - 418, 日本語緩和医療期に達した単心室血行動態の不応性腹水に対し腹水濾過再静注療法が症状緩和に有用であった一例
- 2016年09月, JOURNAL OF CARDIAC FAILURE, 22(9) (9), S210 - S210, 英語Prognostic Impact of Proportional Pulse Pressure (PPP) in Patients with Acute Decompensated Heart Failure (ADHF)研究発表ペーパー・要旨（国際会議）
- 2016年09月, JOURNAL OF CARDIAC FAILURE, 22(9) (9), S189 - S189, 英語Baseline Echocardiographic Features Associated With Improvement in Significant Mitral Regurgitation After Cardiac Resynchronization Therapy-START Study Sub-Analysis研究発表ペーパー・要旨（国際会議）
- 2016年09月, JOURNAL OF CARDIAC FAILURE, 22(9) (9), S179 - S179, 英語How Does Transcathter Aortic Valve Replacement Contribute to Medical Care for Elderly研究発表ペーパー・要旨（国際会議）
- 2016年, 心臓核医学, 18(2) (2)薬剤負荷心筋血流SPECTにおける半導体検出器D-SPECTとAnger型SPECTの欠損スコアの比較
- 2015年11月, CIRCULATION, 132, 英語Prognostic Value of Left Ventricular Global Longitudinal Strain and Ejection Fraction in Patients With Non-ischemic and Ischemic Heart Disease研究発表ペーパー・要旨（国際会議）
- 医学書院, 2014年12月, 臨床検査, 58(13) (13), 1627 - 1636, 日本語画像検査 心エコー図・核医学検査 (特集 とても怖い心臓病ACSの診断と治療)
- 2014年11月, CIRCULATION, 130, 英語Prognostic Significance of Left Ventricular Global Strain and Cardiac Sympathetic Nerve Activity in Patients with Acute Myocardial Infarction Treated with Primary Percutaneous Intervention研究発表ペーパー・要旨（国際会議）
- 2014年11月, CIRCULATION, 130, 英語Right Ventricular Global Longitudinal Strain Improves Diagnostic and Prognostic Assessment in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2014年11月, CIRCULATION, 130, 英語Combination of Global Longitudinal Strain and Sympathetic Nervous Dysfunction Predicts Cardiac Events in Patients With Non-Ischemic Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2014年11月, CIRCULATION, 130, 英語Incremental Prognostic Value of Left Ventricular Global Longitudinal Strain and Late Gadolinium Enhancement in Patients with Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2014年11月, CIRCULATION, 130, 英語Right Ventricular Global Longitudinal Strain is Correlated With Cardiovascular Magnetic Resonanace Ejection Fraction and Provides Prognostic Value in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2014年10月, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S165 - S165, 英語Association between Peripheral Endothelial Function and Left Ventricular Diastolic Function in Patients with Ischemic Heart Disease研究発表ペーパー・要旨（国際会議）
- 2014年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11) (11), B59 - B59, 英語Improvement Of Left Ventricular Function Assessment By Global Longitudinal Strain After Successful Percutaneous Coronary Intervention For Chronic Total Occlusions研究発表ペーパー・要旨（国際会議）
- 2014年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 64(11) (11), B67 - B67, 英語Long-term Safety and Efficacy of Sirolimus Eluting Stent Implantation for Unprotected Left Main Trunk Bifurcation Lesion with Single Stent Strategy Versus Left Anterior Descending Artery Lesion研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Left Atrial "Reservoir" and "Passive Emptying" Reserve During Dobutamine Stress Have Prognostic Relevance for Patients With Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Tissue Doppler Derived Mitral Annular Velocity and Acceleration During Isovolumic Contraction Predict Pulmonary Capillary Wedge Pressure in Patients With Significant Mitral Regurgitation研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Evaluation of Global Circumferential Strain as Prognostic Marker After Administration of beta-blockers for Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Interdependence in the Biventricle and Its Association With Long-Term Outcome in Patients With Pulmonary Hypertension研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Diagnostic Value of Right Ventricular Strain Imaging in Patients With Suspected Arrhythmogenic Right Ventricular Cardiomyopath研究発表ペーパー・要旨（国際会議）
- 2013年11月, CIRCULATION, 128(22) (22), 英語Association of Left Atrial Booster-Pump Function With Heart Failure Symptoms in Patients With Severe Aortic Stenosis and Preserved Ejection Fraction研究発表ペーパー・要旨（国際会議）
- 2013年09月, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 379, 日本語心臓再同期療法における2次元スペックルトラッキング法を用いた簡便かつ有用な評価法 左室同期不全と左室心筋機能評価の検討会議報告等
- (公社)日本超音波医学会, 2013年04月, 超音波医学, 40(Suppl.) (Suppl.), S481 - S481, 日本語Duchenne型筋ジストロフィーにおける機能的僧帽弁閉鎖不全症と僧帽弁形態について[査読有り]
- 2013年04月, 超音波医学, 40(Suppl.) (Suppl.), S459, 日本語左心不全患者における左室拡張機能と心臓交感神経障害の関連会議報告等
- 科学評論社, 2013年02月, 循環器内科, 73(2) (2), 142 - 149, 日本語心エコー図で右心系をいかに評価するか (特集 心不全診療に心エコー図検査を活かす)
- 2013年, 日本心臓病学会誌, 8(Supplement 1) (Supplement 1)経皮的冠動脈形成術施行直後の患者に対する血管内皮機能検査の結果からの考察
- 2012年11月, CIRCULATION, 126(21) (21), 英語Acute Reduction in Strain Dyssynchrony Index with Cardiac Resynchronization Therapy Predicts Mid-Term Left Ventricular Reverse-remodeling and Long-Term Outcome: Using Two-dimensional Speckle-tracking Study研究発表ペーパー・要旨（国際会議）
- 2012年11月, CIRCULATION, 126(21) (21), 英語Contractile Reserve Assessed by Three-Dimensional Global Circumferential Strain as a Predictor of Cardiovascular Events in Patients with Idiopathic Dilated Cartliomyopathy研究発表ペーパー・要旨（国際会議）
- 2012年11月, CIRCULATION, 126(21) (21), 英語Correlation between Right Arterial Pressure and Right Arterial Volume Index in Patients with Pulmonary Hypertension研究発表ペーパー・要旨（国際会議）
- 2012年11月, CIRCULATION, 126(21) (21), 英語Feature of Mechanical Left Ventricular Dyssynchrony in Heart Failure Patients with "Very" Narrow QRS Duration: Using Three-dimensional Speckle-tracking Study研究発表ペーパー・要旨（国際会議）
- 2012年11月, CIRCULATION, 126(21) (21), 英語Dynamic Left Ventricular Dyssynchrony Assessed by Three Dimensional Speckle-Tracking Area Strain during Dobutamine Stress Has a Negative Impact on Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2012年04月15日, 超音波医学, 39, S368, 日本語Duchenne型筋ジストロフィーにおける機能的僧帽弁逆流と左房径の関係について
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1124 - E1124, 英語EVALUATION OF LEFT VENTRICULAR FILLING PRESSURES USING TISSUE DOPPLER DERIVED MYOCARDIAL ACCELERATION DURING ISOVOLUMIC CONTRACTION研究発表ペーパー・要旨（国際会議）
- 2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1141 - E1141, 英語CONTRACTILE RESERVE ASSESSED BY THREE-DIMENSIONAL GLOBAL CIRCUMFERENTIAL STRAIN AS A PREDICTOR OF LONG-TERM OUTCOME IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Utility of Transmural Myocardial Strain Profile to Predict Early Left Ventricular Dysfunction in Patients with Duchenne Muscular Dystrophy研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Multidirectional Left Ventricular Performance Using Three-Dimensional Speckle-Tracking Strain in Patients with Chronic Right Ventricular Pacing and Preserved Ejection Function研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Endocardial Dysfunction in Patients with Chronic Aortic Regurgitation and Preserved Ejection Fraction研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Ability of Comprehensive Assessment of Strain Dyssynchrony Index by Speckle Tracking Imaging to Predict Long-Term Outcome After Cardiac Resynchronization Therapy in Patients with Heart Failure研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Utility of Three-Dimensional Speckle Tracking Radial Strain for Identifying Patients with Cardiac Sarcoidosis研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Left Ventricular Dyssynchrony as a Determinant of Torsional Mechanics in Patients with Dilated Cardiomyopathy研究発表ペーパー・要旨（国際会議）
- 2011年11月, CIRCULATION, 124(21) (21), 英語Regional Heterogeneity of Systolic Dysfunction Leads to Ventricular Dyssynchrony in Patients with Idiopathic Dilated Cardiomyopathy and Narrow QRS Complex; 3-Dimensional Speckle-Tracking Strain Analysis研究発表ペーパー・要旨（国際会議）
- 2011年, 日本循環器学会近畿地方会(Web), 112th心房細動および心房粗動に対するカテーテルアブレーション後に心室細動を発症した一例
- 2010年11月, CIRCULATION, 122(21) (21), 英語Regional Myocardial Systolic Function Using Transmural Myocardial Strain Profile Predicts Postoperative Left Ventricular Systolic Dysfunction in Chronic Aortic Regurgitation研究発表ペーパー・要旨（国際会議）
- 2010年11月, CIRCULATION, 122(21) (21), 英語Area Strain Delay Index by Three-dimensional Speckle Tracking Imaging Predicts Left Ventricular Reverse Remodeling with Cardiac Resynchronization Therapy研究発表ペーパー・要旨（国際会議）
- 2010年09月, JOURNAL OF CARDIAC FAILURE, 16(9) (9), S161 - S161, 英語Loffler's Endocarditis With Severely Impaired Left Ventricular Function and Thrombus研究発表ペーパー・要旨（国際会議）
- (一社)日本透析医学会, 2010年05月, 日本透析医学会雑誌, 43(Suppl.1) (Suppl.1), 675 - 675, 日本語透析患者におけるファブリー病に対する酵素補充療法の効果
- 2009年11月, CIRCULATION, 120(18) (18), S372 - S372, 英語Radial Systolic Strain Rate is a Reliable Predictor of Postoperative Left Ventricular Dysfunction in Chronic Aortic Regurgitation研究発表ペーパー・要旨（国際会議）
- 2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S166 - S166, 英語Left Ventricular Dyssynchrony With Sever Aortic Valve Stenosis is Improved With Aortic Valve Replacement研究発表ペーパー・要旨（国際会議）
- 2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S180 - S180, 英語Reverse Remodeling Induces Progressive Ventricular Resynchronization After Cardiac Resynchronization Therapy - From Vicious to Virtuous Cycle研究発表ペーパー・要旨（国際会議）
- 2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S160 - S160, 英語The Usefulness of Handgrip Stress Echocardiography With Segmental Stsystolic Strain Analysis in Patients With Coronary Artery Disease研究発表ペーパー・要旨（国際会議）
- 2009年08月, 日本心臓病学会誌, 4巻, Suppl.I, pp. 133-133, 日本語最新の弁膜症診療と心エコーの役割 大動脈弁形成術に対する心エコー図検査の役割記事・総説・解説・論説等（学術雑誌）
- 社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 383 - 383, 英語DPJ-029 Left Ventricular Dyssynchrony Using Tissue Doppler Strain Imaging Predicts Postoperative Left Ventricular Systolic Dysfunction in Patients with Chronic Aortic Regurgitation(DPJ05,Echo/Doppler (Myocardium) (I),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 671 - 672, 英語PJ-499 Speckle Tracking Circumferential Septal-Lateral Dyssynchrony Predicts Response to Cardiac Resynchronization Therapy(PJ084,CRT (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 670 - 670, 英語PJ-491 Washout Phenomenon on 99mTc-tetrofosmin Myocardial Perfusion SPECT Predicts Beneficial Effects for Cardiac Resynchronization Therapy in Patients with Dilated Cardiomyopathy(PJ083,Nuclear Cardiology (Coronary, Myocardium) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 438 - 438, 英語PE-156 Acute Response of Regional Early Diastolic Function with Cardiac Resynchronizaiton Therapy Predicts Chronic Response of Global Left Ventricular Systolic Function(PE026,Cardiac Function (Clinical) 1 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- (公社)日本小児科学会, 2009年02月, 日本小児科学会雑誌, 113(2) (2), 286 - 286, 日本語Duchenne型筋ジストロフィーにおける下肢挙上法による心機能評価の有用性[査読有り]
- 2008年10月, CIRCULATION, 118(18) (18), S932 - S933, 英語Myocardial Radial Strain Rate Indicates Prognostic Significance in Asymptomatic Patients with Chronic Severe Aortic Regurgitation研究発表ペーパー・要旨（国際会議）
- 2008年09月, CIRCULATION, 118(12) (12), E185 - E185, 英語The role of abnormal Q waves and ST-segment elevation as a marker for disease progression in hypertrophic cardiomyopathy研究発表ペーパー・要旨（国際会議）
- (公社)日本医学放射線学会, 2008年09月, 日本医学放射線学会秋季臨床大会抄録集, 44回, S505 - S505, 日本語心臓Fabry病にMRIを施行した1例
- 日本心臓病学会, 2008年05月15日, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 1(3) (3), 169 - 173, 日本語好酸球増多症候群に合併した大動脈弁閉鎖不全症の1例
- 社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 585 - 585, 英語PJ-293 Association of Left Ventricular Afterload Mismatch with Reduced Myocardial Contractile Reserve in Reverse-remodeled Dilated Cardiomyopathy Patients Assessed by Strain Imaging(Echo/Doppler(14)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 462 - 463, 英語PE-410 Prognostic Value of Myocardial Peak Systolic Strain rate in Asymptomatic Patients with Chronic Severe Aortic Regurgitation(Echo/Doppler(08)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 671 - 671, 英語PJ-630 The Usefulness of Left Atrial Strain Rate for Evaluating Left Atrial Function in Patients with Hypertrophic Cardiomyopathy(Cardiomyopathy, basic / clinical(06)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 268 - 268, 英語OE-351 Myocardial Systolic Function in the Region of Left Ventricular Pacing Lead Predicts the Response to Cardiac Resynchronization Therapy(Heart failure, clinical(04)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- 2008年, 日本臨床, 巻, 別冊循環器症候群III, pp. 190-195【循環器症候群(第2版) その他の循環器疾患を含めて】 心筋疾患 潜在性心筋症
- 2008年, 心エコー, 9巻, 1号, pp. 52-59【ここが知りたい心エコーQ&A2008 計測編】 ドプラ法による計測 経僧帽弁血流
- 社団法人日本循環器学会, 2007年10月20日, Circulation journal : official journal of the Japanese Circulation Society, 71, 1005 - 1005, 日本語143)肺動脈血栓内膜摘除術が奏功した若年発症の慢性肺動脈血栓塞栓症の一例(第103回日本循環器学会近畿地方会)
- 2007年04月15日, Journal of medical ultrasonics = 超音波医学, 34, S139, 英語Assessment of Myocardial Function Using Strain and Strain Rate Imaging
- 2007年04月, CIRCULATION JOURNAL, 71(4) (4), 517 - 523, 英語
- 2007年04月, CIRCULATION JOURNAL, 71(4) (4), 517 - 523, 英語
- 社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 242 - 242, 英語OE-365 Preoperative Systolic Strain Rate Predicts Postoperative Left Ventricular Systolic Function in Patients with Chronic Aortic Regurgitation(Valvular heart disease/Pericarditis/Cardiac tumor-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 394 - 394, 英語PE-277 Reduction of Functional Mitral Regurgitation is Associated with Improving Inferior Myocardial Function with Dobutamine Administration Assessed by Strain Rate Imaging(Valvular heart disease/Pericarditis/Cardiac tumor-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 71 - 71, 英語1 Results of Valve-Sparing Aortic Root Replacement for Annuloaortic Ectasia and Moderate to Severe Aortic Regurgitation(Aortic Valve-Sparing Operations In Patients With Aortic Root Aneurysms, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 2007年, Heart View, 11巻, 12号, pp. 161-163【心エコー図診断のためのKey Word】 虚血性心疾患 合併症
- 2007年, 核医学, 44巻, 3号, pp. 282-283心サルコイドーシス患者の局所左室機能回復予測における99mTc-テトロフォスミン心筋Washoutの有用性
- 2007年, 超音波医学, 34巻, 6号, pp. 620-621左室内血栓を伴った左室緻密化障害の1例
- 2007年, 心エコー, 8巻, 8号, pp. 702-712【はじめての心エコー】 読み方 壁の診かた
- 2007年, Circulation Journal, 71巻, Suppl.II, pp. 915-915好酸球増多症候群に合併した大動脈弁閉鎖不全症の一例
- 2007年, 超音波医学, 34巻, Suppl., pp. S581-S581肥大型心筋症における左房ストレインレートを用いた左房機能評価
- 2007年, 超音波医学, 34巻, Suppl., pp. S578-S578急速に進行した感染性心内膜炎の一例
- 2007年, Journal of Cardiology, 50(2) (2), 155 - 157, 英語Echocardiographic findings of intracardiac mass
- 2007年, Journal Of Cardiology, Vol. 50, No. 1, pp. 65-70(1) (1), 65 - 70, 英語Accessory mitral valve associated with aortic and mitral regurgitation and left ventricular outflow tract obstruction in an elderly patient: a case report
- 2007年, Journal of Cardiology, 50(2) (2), 155 - 157, 英語Echocardiographic findings of intracardiac mass
- 2007年, Journal of cardiology, Vol. 50, No. 1, pp. 65-70(1) (1), 65 - 70, 英語大動脈弁, 僧帽弁閉鎖不全症と左室流出路狭窄を伴った高齢者の僧帽弁副組織の1例
- 2006年10月, CIRCULATION, 114(18) (18), 759 - 759, 英語Reduction of functional mitral regurgitation is associated with improving inferior myocardial systolic function with low-dose dobutamine in patients with dilated cardiomyopathy assessed by tissue Doppler echocardiography研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 715 - 715, 英語Preoperative regional myocardial systolic index predicts postoperative left ventricular systolic function in patients with chronic aortic regurgitation assessed by tissue Doppler strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 715 - 715, 英語Preoperative regional myocardial systolic index predicts postoperative left ventricular systolic function in patients with chronic aortic regurgitation assessed by tissue Doppler strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 759 - 759, 英語Reduction of functional mitral regurgitation is associated with improving inferior myocardial systolic function with low-dose dobutamine in patients with dilated cardiomyopathy assessed by tissue Doppler echocardiography研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 715 - 715, 英語Preoperative regional myocardial systolic index predicts postoperative left ventricular systolic function in patients with chronic aortic regurgitation assessed by tissue Doppler strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2006年10月, CIRCULATION, 114(18) (18), 715 - 715, 英語Preoperative regional myocardial systolic index predicts postoperative left ventricular systolic function in patients with chronic aortic regurgitation assessed by tissue Doppler strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 742 - 742, 英語Prediction of left ventricular systolic function after surgical correction with regional myocardial peak systolic strain rate in patients with chronic aortic regurgitation研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 603 - 603, 英語Acute response to cardiac resynchronization therapy in patients with segmental paradoxical systolic expansion assessed by strain imaging研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 742 - 742, 英語Prediction of left ventricular systolic function after surgical correction with regional myocardial peak systolic strain rate in patients with chronic aortic regurgitation研究発表ペーパー・要旨（国際会議）
- 2006年08月, EUROPEAN HEART JOURNAL, 27, 603 - 603, 英語Acute response to cardiac resynchronization therapy in patients with segmental paradoxical systolic expansion assessed by strain imaging研究発表ペーパー・要旨（国際会議）
- 2006年07月, 臨床画像, 22(7号) (7号), 791 - 799, 日本語【肺血栓塞栓症に必要な画像診断およびIVR】 肺血栓塞栓症と深部静脈血栓症のIVR治療[査読有り][招待有り]記事・総説・解説・論説等（学術雑誌）
- 2006年06月, JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 19(6) (6), 756 - 762, 英語
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 425 - 425, 英語PE-366 Quantitative Assessment of the Functional Mitral Regurgitation during Dobutamine Stress by Tissue Doppler Imaging(Echo/Doppler-8 (I) PE61,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 446 - 446, 英語PE-451 Assessment of Regional Intramyocardial Function Using Strain Rate Imaging in Patients with Coronary Artery Disease During Low-dose Dobutamine Stress Echocardiography(Echo/Doppler-7 (I) PE76,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 社団法人日本循環器学会, 2006年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 70, 144 - 144, 英語FRS-120 Improvement in Regional Myocardial Systolic Function Assessed by Transmural Myocardial Strain Profile after Surgical Correction for Chronic Aortic Regurgitation(Recent Advance in Echocardiography-2 (I) FRS24,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 2006年閉塞性肥大型心筋症に対し心筋切除術を行い改善した一例
- 2006年虚血性心疾患における虚血心筋領域の局所拡張能に対する経皮的冠動脈形成術の改善効果 －Strain rate imaging法を用いた検討－
- 2006年肺静脈経由に左房内に進展した胚細胞腫の一例
- 2006年新しい左房ストレイン指標による左房リザーバー機能の評価
- 2006年慢性大動脈弁閉鎖不全症に対する外科的治療による左室機能の変化
- 2006年左室局所の奇異性運動を有する慢性心不全患者では心臓再同期療法による急性効果が大きい
- 2006年左室全体機能と局所心筋機能の関連性
- 2006年低左心機能症例における左房strain / strain rateによる左房機能評価
- 2006年ドブタミン負荷組織ドプラ心エコー図法による局所心機能と慢性機能性僧帽弁逆流の検討
- 2006年Usefulness of Assessing Myocardial Washout of 99m Tc--tetrofosmin for Prediction of Prognosis in Patients with Cardiac Sarcoidosis
- 2006年Strain rate imaging法を用いた慢性大動脈弁閉鎖不全症患者の外科的治療後の左室収縮能の予測
- 2006年Relationship Between Global and Regional Left ar Systolic and Diastolic Function inPatients with Coronary Artery Disease Assessed by Strain Rate Imaging
- 2006年Reduction of Functional Mitral Regurgitation is Associated with Improving Inferior Myocardial Systolic Function with Low-dose Dobutamine Assessed by Tissue Doppler Imaging
- 2006年Reduction of Functional Mitral Regurgitation is Associated with Improving Inferior Myocardial Function with Dobutamine Administration Assessed by Strain Rate Imaging
- 2006年Relationship Between Global and Regional Left Ventricular Systolic and Diastolic Function in Patients with Coronary Artery Disease Assessed by Strain Rate Imaging
- 2006年Assessment of Regional Myocardial Systolic Function in Chronic Aortic Regurgitation before and after Surgical Correction Using Transmural Myocardial Strain Profile
- 2006年術前診断に経食道エコー図検査が有用であった大動脈基部限局性解離の一例.
- 2006年, 超音波医学, 33巻, 3号, pp. 427-427心室中部の閉塞性肥大型心筋症に対して心筋切除術を行った1例
- 2006年, 臨床画像, 22巻, 7号, pp. 760-777【肺血栓塞栓症に必要な画像診断およびIVR】 深部静脈血栓症におけるUS診断
- 2006年, Journal of Cardiology, 48巻, Suppl.I, pp. 336-336Strain rate imaging法を用いた慢性大動脈弁閉鎖不全症患者の外科的治療後の左室収縮能の予測
- 2006年, Journal of Cardiology, 48巻, Suppl.I, pp. 609-609左室機能低下症例における左房strain/strain rate指標による左房機能評価
- 2006年, Journal of Cardiology, 48巻, Suppl.I, pp. 691-691ドブタミン負荷組織ドプラ心エコー図法による局所心機能と慢性機能性僧帽弁逆流の検討
- 2006年, Circulation Journal, 70巻, Suppl.III, pp. 1225-1225慢性虚血性僧帽弁逆流2症例のドブタミン負荷組織ドプラ心エコー図法による検討
- 2006年, Circulation Journal, 70巻, Suppl.III, pp. 1226-1226術前診断に経食道心エコー図検査が有用であった大動脈基部限局性解離の一例
- 2006年, Journal Of Cardiology, Vol. 47, No. 4, pp. 207-213, 207 - 213Surgical treatment for Loffler's endocarditis with left ventricular thrombus and severe mitral regurgitation: a case report
- 2006年, Journal of Cardiology, 47巻, 4号, pp. 207-213左室壁在血栓と高度僧帽弁逆流を伴ったLoeffler心内膜心筋炎に対して外科手術を施行した1例(Surgical Treatment for Loeffler's Endocarditis With Left Ventricular Thrombus and Severe Mitral Regurgitation: A Case Report)(英語)
- 2006年, 超音波医学, 33巻, Suppl., pp. S375-S375閉塞性肥大型心筋症に対し心筋切除術を行い改善した一例
- 2006年, 超音波医学, 33巻, Suppl., pp. S332-S332左室全体機能と局所心筋機能の関連性
- 2006年, 超音波医学, 33巻, Suppl., pp. S323-S323慢性大動脈弁閉鎖不全症に対する外科的治療による左室機能の変化
- 2006年, 心エコー, 7巻, 4号, pp. 278-286Fundamental Lesson 読み方 肺血栓塞栓症の心エコー
- A 45-year-old woman was admitted to our hospital because of exertional dyspnea. At the age of 26, she was diagnosed with corrected transposition of the great arteries (CTGA) and mild left atrioventricular valve (LAVV) regurgitation. On admission, transthoracic echocardiography revealed severe LAVV regurgitation related to CTGA. The appropriate timing of LAVV replacement in CTGA patients remains unclear. In this case, severe LAVV regurgitation was demonstrated; the anatomic right ventricle had gradually enlarged; systolic function of the anatomic right ventricle was slightly reduced; and sinus rhythm was still maintained, so we opted for valve replacement.Japanese Society of Echocardiography, 2006年, J Echocardiogr, Vol. 4, No. 1, pp. 34-36(1) (1), 34 - 36, 英語
- 2006年Usefulness of Assessing Myocardial Washout of 99m Tc--tetrofosmin for Prediction of Prognosis in Patients with Cardiac Sarcoidosis
- 2006年Relationship Between Global and Regional Left ar Systolic and Diastolic Function inPatients with Coronary Artery Disease Assessed by Strain Rate Imaging
- 2006年Reduction of Functional Mitral Regurgitation is Associated with Improving Inferior Myocardial Systolic Function with Low-dose Dobutamine Assessed by Tissue Doppler Imaging
- 2006年Reduction of Functional Mitral Regurgitation is Associated with Improving Inferior Myocardial Function with Dobutamine Administration Assessed by Strain Rate Imaging
- 2006年Relationship Between Global and Regional Left Ventricular Systolic and Diastolic Function in Patients with Coronary Artery Disease Assessed by Strain Rate Imaging
- 2006年Assessment of Regional Myocardial Systolic Function in Chronic Aortic Regurgitation before and after Surgical Correction Using Transmural Myocardial Strain Profile
- 2006年, Journal Of Cardiology, Vol. 47, No. 4, pp. 207-213Surgical treatment for Loffler's endocarditis with left ventricular thrombus and severe mitral regurgitation: a case report
- A 45-year-old woman was admitted to our hospital because of exertional dyspnea. At the age of 26, she was diagnosed with corrected transposition of the great arteries (CTGA) and mild left atrioventricular valve (LAVV) regurgitation. On admission, transthoracic echocardiography revealed severe LAVV regurgitation related to CTGA. The appropriate timing of LAVV replacement in CTGA patients remains unclear. In this case, severe LAVV regurgitation was demonstrated; the anatomic right ventricle had gradually enlarged; systolic function of the anatomic right ventricle was slightly reduced; and sinus rhythm was still maintained, so we opted for valve replacement.Japanese Society of Echocardiography, 2006年, Journal of Echocardiography, Vol. 4, No. 1, pp. 34-36(1) (1), 34 - 36, 英語
- 2005年09月, EUROPEAN HEART JOURNAL, 26, 300 - 300, 英語Improvement of regional myocardial diastolic function in patients with coronary artery disease undergoing percutaneous coronary intervention as assessed by strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2005年09月, EUROPEAN HEART JOURNAL, 26, 300 - 300, 英語Improvement of regional myocardial diastolic function in patients with coronary artery disease undergoing percutaneous coronary intervention as assessed by strain rate imaging研究発表ペーパー・要旨（国際会議）
- 2005年05月, INTERNATIONAL HEART JOURNAL, 46(3) (3), 407 - 417, 英語
- 2005年05月, INTERNATIONAL HEART JOURNAL, 46(3) (3), 407 - 417, 英語
- 2005年高度肥満から重症心不全をきたした1例．
- 2005年Quantitative Assessment of the Functional Mitral Regurgitation during Dobutamine Stress by tissue Doppler imaging
- 2005年Improvement in Regional Myocardial Systolic Function Assessed by Transmural Myocardial Strain Profile after Surgical Correction for Chronic Aortic Regurgitation
- 2005年Assessment of Regional Intramyocardial Function Using Strain Rate Imaging in Patients with Coronary Artery Disease During Low-dose Dobutamine Stress Echocardiography
- 2005年大動脈二尖弁を合併したバルサルバ洞動脈瘤破裂の１例
- 2005年unroofed coronary sinusの１例
- 2005年慢性大動脈弁閉鎖不全症における左室局所心筋収縮能の評価
- 2005年右室内心臓横紋筋肉腫の肺動脈閉塞により突然死に至った一例
- 2005年慢性完全閉塞病変を有する冠動脈疾患患者に対する再灌流療法の慢性効果－運動／ATP負荷心電図同期SPECTによる検討－
- 2005年心筋ストレイン法を用いた慢性大動脈弁閉鎖不全症における局所心筋障害の検討
- 2005年ストレインレート指標を用いた慢性大動脈弁閉鎖不全患者の左室心筋収縮能の評価：外科的治療法前後での検討
- 2005年高度の肥満に伴う左心不全の一例
- 2005年著明な接合不全を伴う重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例
- 2005年僧帽弁副組織の1例
- 2005年ストレインレート指標を用いた慢性大動脈弁閉鎖不全症患者の左室心筋収縮能に及ぼす外科的治療法の効果
- 2005年, 超音波医学, 33巻, 1号, pp. 102-103unroofed coronary sinusの1例
- 2005年, Journal of Cardiology, 46巻, Suppl.I, pp. 263-263心筋ストレイン法を用いた慢性大動脈弁閉鎖不全症における局所心筋障害の検討
- 2005年, 超音波医学, 32巻, 4号, pp. 425-425僧帽弁副組織の1例
- 2005年, 超音波医学, 32巻, 4号, pp.432-432著明な接合不全を伴う重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例
- 2005年, 超音波医学, 32巻, 4号, pp.425-425慢性大動脈弁閉鎖不全症の局所収縮能の定量的評価
- 2005年, 超音波医学, 32巻, 増刊, pp.S373-S373慢性大動脈弁閉鎖不全症における左室局所心筋収縮能の評価
- 2005年, 超音波医学, 33巻, 1号, pp.102-102大動脈二尖弁を合併したバルサルバ洞動脈瘤破裂の1例
- 2005年, 超音波医学, 32巻, 増刊, pp.S530-S530右室内心臓横紋筋肉腫の肺動脈閉塞により突然死に至った一例
- 2005年, 超音波医学, 32巻, 4号, pp.426-426右室内心臓横紋筋肉腫の肺動脈閉塞により突然死に至った1例
- 2005年, 核医学, 42巻, 3号, pp.319-319慢性完全閉塞病変に対する再灌流療法の慢性効果 負荷心電図同期SPECTによる検討
- 2005年, 日本臨床救急医学会雑誌, 8巻, 2号, pp.134-134高度肥満から重症心不全をきたした1例
- 2005年, 循環器専門医, 13巻, 2号, pp.315-318循環器学2005年の進歩 心臓核医学研究の進歩
- 2005年, The Circulation Frontier, 9巻, 3号, pp.67-69心膜液貯留で発症した心臓血管腫に対して外科的治療を行った1例
- 2005年, Journal of Cardiology, 46巻, Suppl.I, pp.263-263ストレインレート指標を用いた慢性大動脈弁閉鎖不全症患者の左室心筋収縮能の評価 外科的治療法前後での検討
- 2005年, Circulation Journal, 69巻, Suppl.II, pp.868-868発作性心房細動に対するカテーテルアブレーションにより,著明な心機能改善を認めた頻脈誘発性心筋症の一例
- 2005年, 永井書店シミュレイション内科 心不全を探る / 疾患編 ８ 以前より風邪をひきやすかった 最近足がむくんで、急いで歩くと息切れが！？
- 2005年Quantitative Assessment of the Functional Mitral Regurgitation during Dobutamine Stress by tissue Doppler imaging
- 2005年Improvement in Regional Myocardial Systolic Function Assessed by Transmural Myocardial Strain Profile after Surgical Correction for Chronic Aortic Regurgitation
- 2005年Assessment of Regional Intramyocardial Function Using Strain Rate Imaging in Patients with Coronary Artery Disease During Low-dose Dobutamine Stress Echocardiography
- 2004年07月, AMERICAN JOURNAL OF ROENTGENOLOGY, 183(1) (1), 91 - 98, 英語MR angiography with sensitivity encoding (SENSE) for suspected pulmonary embolism: Comparison with MDCT and ventilation-perfusion scintigraphy
- 2004年肥大型心筋症における局所心筋機能障害に関する検討
- 2004年ストレインレート法による局所心筋のドブタミンに対する反応性
- 2004年発作性心房細動に対するカテーテルアブレーションにより、著明な心機能改善を認めた頻脈誘発性心筋症の一例
- 2004年シェーグレン症候群に伴う肺高血圧症に対しクエン酸シルデナフィル投与が有効であった一症例
- 2004年Myocardial Distribution of Systolic Strain During Low-Dose Dobutamine Stress Echocardiography Using Strain Profile
- 2004年Influences of Coronary Risk Factors on the Diagnostic Accuracy by ATP Stress Myocardial Perfusion Imaging
- 2004年肥大心における局所心筋収縮能の左室壁内分布に関する検討
- 2004年Strain profileによる局所心筋における左室壁内の最大収縮部位の検討
- 2004年慢性大動脈弁閉鎖不全症における左室局所心筋収縮能の評価
- 2004年右室内心臓横紋筋肉腫の肺動脈閉塞により突然死に至った一例
- 2004年僧帽弁副組織の１例
- 2004年一過性に僧帽弁の可動制限による著明な接合不全を来たした重症僧帽弁閉鎖不全症に対して僧帽弁輪形成術を施行した1例
- 2004年ストレインレート影像法による肥大型心筋症の局所心筋壁内収縮動態の検討
- 2004年Cardiac hemangiomaの1例
- 2004年慢性完全閉塞病変を有する冠動脈疾患患者に対する再灌流療法の慢性効果－運動/ATP負荷心電図同期SPECTによる検討－
- 2004年心臓核医学を用いた急性心筋梗塞（AMI）の再灌流療法による局所心機能回復の予測
- 2004年, 超音波医学, 31巻, Suppl., pp. S138-S138肥大型心筋症における局所心筋機能障害に関する検討
- 2004年, 超音波医学, 31巻, 4号, pp. J275-J275子宮頸癌の心臓転移の1例
- 2004年, 超音波医学, 31巻, Suppl., pp. S160-S160ストレインレート法による局所心筋のドブタミンに対する反応性
- 2004年, 診断と治療, 93巻, 1号, pp. 78-83【心不全 最新の診断と治療】 心不全の治療 β遮断薬療法の実際
- 2004年, 日本整形外科学会雑誌, 79巻, 3号, pp. S99-S99人工関節置換術後の経時的凝固線溶系マーカーの検討 TKAとTHAの比較
- 2004年, 心臓, 37巻, 1, pp. 44-50臨床経過を長期間観察し得た,高度の心筋病変を有するBecker型筋ジストロフィーの1例
- 2004年, 心臓, 36巻, 4, pp. 309-313
- 2004年, 心エコー, 6巻, 2号, pp. 102-115【心エコーで心不全の治療方針を決める】 心不全の治療方針決定に心エコーをどう活かすか?
- 2004年, 心エコー, 6巻, 3号, pp. 226-235Fundamental Lesson 読み方 カラードプラ法を中心とした大動脈弁逆流の重症度診断
- 2004年, Therapeutic Research, 25巻, 6号, pp. 1214-1216当院における急性肺塞栓症の治療経験,外科的塞栓摘出術の有用性
- 2004年, THE CIRCULATION FRONTIER, 8巻, 2号, pp. 76-79左室内血栓と高度僧帽弁逆流を伴い重症うっ血性心不全をきたしたLoeffler心内膜心筋炎に外科的治療を行った一例
- 2004年, Journal of Cardiology, 44巻, Suppl.I, pp. 279-279肥大心における局所心筋収縮能の左室壁内分布に関する検討
- 2004年, Journal of Cardiology, 44巻, Suppl.I, pp. 252-252Strain profileによる局所心筋における左室壁内の最大収縮部位の検討
- 2004年, Circulation Journal, 68巻, Suppl.III, pp. 937-937シェーグレン症候群に伴う肺高血圧症に対しクエン酸シルデナフィル投与が有効であった一症例
- 2004年, Cardiac Practice, 15巻, 4号, pp. 357-363【原発性肺高血圧症治療の最近の進歩】 診断
- 2004年, メジカルセンス症例提示Ⅱ慢性症候群 Ｃ－２．特定の患者集団：正常な安静時心電図で運動可能な患者 / 症例から学ぶACC/AHA/ASNCの心臓核医学ガイドライン
- 2004年Myocardial Distribution of Systolic Strain During Low-Dose Dobutamine Stress Echocardiography Using Strain Profile
- 2004年Influences of Coronary Risk Factors on the Diagnostic Accuracy by ATP Stress Myocardial Perfusion Imaging
- American Roentgen Ray Society, 2004年, American Journal of Roentgenology, 183(1) (1), 91 - 98, 英語
- (一社)中部日本整形外科災害外科学会, 2003年11月, 中部日本整形外科災害外科学会雑誌, 46(6) (6), 1177 - 1177, 日本語THA(人工股関節全置換術)後に肺血栓塞栓症を生じ開心術にて救命し得た1例
- 2003年10月, CIRCULATION JOURNAL, 67(10) (10), 855 - 860, 英語
- 2003年10月, CIRCULATION JOURNAL, 67(10) (10), 855 - 860, 英語
- 社団法人日本循環器学会, 2003年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 67, 455 - 455, 英語Transthoracic Doppler Echocardiographical Assessment of Coronary Flow Velocity Characteristics in Patient with Chronic Aortic Regurgitation
- 2003年虚血性心疾患における虚血部局所心筋機能に対する経皮的冠動脈インターベンションの効果-Strain rate imaging法を用いた検討
- 2003年急性心筋梗塞における再灌流治療後の心機能回復の予測-安静時心電図同期SPECTと123I-BMIPPイメージ ングによる検討
- 2003年負荷心筋血流シンチグラフィー正常例における予後予測の検討
- 2003年拡張型心筋症における心筋脂肪酸摂取率とβ遮断薬療法による心機能改善との関連性
- 2003年多枝病変を有する急性心筋梗塞における非梗塞領域の虚血評価-ATP負荷心筋血流シンチグラフィーによる検討
- 2003年AMIにおけるdistal protection device (DPD)の心筋保護効果：安静時Gated SPECTによる検討
- 2003年子宮頸癌の心臓転移の1例
- 2003年著明な全身の動脈硬化病変を有しMRSAによる感染症大動脈瘤、細菌性心外膜炎を併発した一剖検例
- 2003年子宮筋腫に合併した慢性肺血栓塞栓症の一例
- 2003年Impaired regional myocardial strain rate in hypertrophic cardiomyopathy assessed by tisue Doppler echoardiography
- 2003年左室壁在血栓と僧帽弁逆流を伴ったLoffler心内膜心筋炎の1例
- 2003年孤立性心筋内転移をきたした子宮頸癌の一例
- 2003年冠動脈疾患患者における運動負荷後局所壁運動動態の変化 -strain法による検討-
- 2003年健常例における収縮期および拡張期の局所壁運動動態-ストレインレート映像法による検討
- 2003年Strain rate imaging法を用いた虚血性心疾患における局所心筋の収縮能と拡張能の関係
- 2003年, 核医学, 40巻, 3号, pp. 320-320(1) (1), 57 - 75, 日本語AMIにおけるdistal protection device(DPD)の心筋保護効果 安静時Gated SPECTによる検討
- 2003年Impaired regional myocardial strain rate in hypertrophic cardiomyopathy assessed by tisue Doppler echoardiography
- 診断と治療社, 2001年09月, 診断と治療, 89(9) (9), 1547 - 1556, 日本語慢性虚血性心疾患の診断と病態把握のための検査法の選択基準に関するガイドライン (特大号 いま必要な診療ガイドライン--その使い方を中心に) -- (循環器)
- 1996年, 特発性心筋症調査研究班 平成7年度研究報告集拡張型心筋症の不整脈並びに心機能と予後 (厚生省S)
- 1996年, 心臓 特別号, 28(6) (6)拡張型心筋症の心機能,心室性不整脈並びに突然死に対するACE阻害薬およびβ遮断薬の有用性
- 1995年, 臨床成人病, 25, 1696 - 1702拡張型心筋症-病像 診断
- 1994年, Medicina, 31(7) (7)循環器薬の使い方 1994 心筋症 拡張型心筋症治療薬の使い方
- 1993年, 臨床成人病, 23(12) (12)特集 心疾患の診療・up to date-一般内科医のために II. 心疾患の最近の話題-治療 拡張型心筋症のβ遮断薬療法
- 1993年, Medicina, 30(13) (13)循環器疾患の画像診断 どう診断するか-選択と読み方 拡張型心筋症
- 日本心臓核医学会ニュースレター, 2024年05月, 日本語, 日本心臓核医学会心アミロイドーシスの診断手順を考える
- 日本循環器学会学術集会抄録集, 2024年03月, 英語, (一社)日本循環器学会Impact of Residual Mitral Regurgitation and Stenosis on Prognosis after MitraClip(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2024年03月, 英語, (一社)日本循環器学会Impact of MR-detected High Intensity Plaque in EVT for SFA-CTO(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2024年03月, 英語, (一社)日本循環器学会Comparison of Therapeutic Effects with MitraClip According to Etiology of Mitral Regurgitation(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2024年03月, 英語, (一社)日本循環器学会Factors and Prognostic Impact of Non-Bystader CPR in ECPR Performing Facilities(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2024年03月, 英語, (一社)日本循環器学会Long-term Cardiovascular Outcomes of Drugcoated Balloon for Large-vessel de-novo Lesions or In-stent Restenosis(タイトル和訳中)
- 植込みデバイス関連冬季大会プログラム・抄録集(Web), 2024年リードレスペースメーカの早期閾値上昇から再植込みを要した1例
- 日本超音波医学会関西地方会学術集会, 2023年10月, 日本語, (公社)日本超音波医学会-関西地方会これぞ負荷心エコーの醍醐味 心サルコイドーシスの一例
- 日本心臓病学会学術集会抄録, 2023年09月, 日本語, (一社)日本心臓病学会当院の息切れ外来について
- 日本心血管インターベンション治療学会抄録集, 2023年08月, 英語, (一社)日本心血管インターベンション治療学会LAD入口部病変に対するDCA+DCBの有効性の検討
- 日本心血管インターベンション治療学会抄録集, 2023年08月, 英語, (一社)日本心血管インターベンション治療学会川崎病冠疾患に対する至適PCIとは 川崎病後急性冠症候群へのELCAと冠動脈内血栓溶解療法による治療効果
- 日本肺高血圧・肺循環学会学術集会抄録集, 2023年06月, 日本語, 日本肺高血圧・肺循環学会気腫合併肺線維症と心不全よりPHを呈した症例の治療
- 日本肺高血圧・肺循環学会学術集会抄録集, 2023年06月, 日本語, 日本肺高血圧・肺循環学会肺高血圧症が初発症状であった高安動脈炎の一例
- 日本心臓核医学会ニュースレター, 2023年05月, 日本語, 日本心臓核医学会運動誘発性冠攣縮性狭心症と考えられた症例
- 日本心臓核医学会ニュースレター, 2023年05月, 日本語, 日本心臓核医学会多枝急性冠症候群の残存虚血をFFR-CTとRIで行った1例
- 日本心臓核医学会ニュースレター, 2023年05月, 日本語, 日本心臓核医学会ガイドラインの変遷のなかで7年の経過で画像診断から治療選択をしえた症例
- 日本循環器学会学術集会抄録集, 2023年03月, 英語, (一社)日本循環器学会Efficacy and Safety of Catheter Ablation in Very Elderly Patients with Atrial Fibrillation(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2023年03月, 英語, (一社)日本循環器学会The Impact of Residual Pulmonary Hypertension on Cardiovascular Events in Patients with Functional Mitral Regurgitation after Transcatheter Mitral Valve Repair(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2023年03月, 英語, (一社)日本循環器学会Evaluating the Usefulness of IMPELLA in Patients with Acute Heart Failure Presenting with Cardiogenic Shock(タイトル和訳中)
- 日本循環器学会学術集会抄録集, 2023年03月, 英語, (一社)日本循環器学会Efficacy of Native T1 Mapping in Patients with Non-Ischemic Cardiomyopathy Undergoing Transcatheter Mitral Valve Repair(タイトル和訳中)
- 植込みデバイス関連冬季大会プログラム・抄録集(Web), 2023年除細動機能付き両室ペースメーカ(CRT-D)植込み後のデバイス感染に伴うリード抜去に難渋した1例
- 日本心血管インターベンション治療学会抄録集, 2022年07月, 英語, (一社)日本心血管インターベンション治療学会院外心停止患者に対する体外循環式心肺蘇生(ECPR)の予後規定因子の検討
- 日本心血管インターベンション治療学会抄録集, 2022年07月, 英語, (一社)日本心血管インターベンション治療学会Impella CPの出血性合併症に対しての16Frシース使用の有用性検討
- 日本心血管インターベンション治療学会抄録集, 2022年07月, 英語, (一社)日本心血管インターベンション治療学会急性冠症候群に対するDCA+DCBの有効性の検討
- 超音波医学, 2022年04月, 日本語, (公社)日本超音波医学会経皮的僧帽弁修復術後の中隔穿刺部位に血栓を認めた一例
- 日本超音波医学会関西地方会学術集会, 2021年10月, 日本語, (公社)日本超音波医学会-関西地方会経皮的僧帽弁形成術後の中隔穿刺部に嵌入した巨大血栓を認めた一例
- 日本超音波医学会関西地方会学術集会, 2021年10月, 日本語, (公社)日本超音波医学会-関西地方会蛋白漏出性胃腸症を伴う術後収縮性心膜炎に対して心膜剥離術が奏功した一例
- 日本循環器学会学術集会抄録集, 2017年03月, 英語, (一社)日本循環器学会経静脈植込み型除細動器(ICD)患者と皮下ICD患者との不整脈性失神の差(The Difference in Arrhythmic Syncope between Patients with Transvenous and Subcutaneous Implantable Cardioverter-Defibrillators)
- 日本循環器学会学術集会抄録集, 2017年03月, 英語, (一社)日本循環器学会経カテーテル大動脈弁留置術の候補者で緊急バルーン大動脈弁形成を要した患者は予後不良である(The Poor Prognosis of Candidates for Transcatheter Aortic Valve Implantations Who Required Emergency Balloon Aortic Valvuloplasties)
- 日本心臓病学会学術集会抄録, 2016年09月, 日本語, (一社)日本心臓病学会経カテーテル的大動脈弁留置術後の予後関連因子の検討
- 日本心臓核医学会ニュースレター, 2016年06月, 日本語, 日本心臓核医学会胸腹部動脈流へのステントグラフト術前患者への心筋虚血評価
- 日本心臓病学会学術集会抄録, 2014年09月, 日本語, (一社)日本心臓病学会急性非代償性心不全の動脈血液ガス分析によって認める呼吸循環動態における収縮期血圧と左室収縮能の関連性
- 心電図, 2013年09月, 日本語, (一社)日本不整脈心電学会CHA2DS2-VASc score=0の非弁膜症性心房細動症例に対する新規抗凝固薬使用に関する検討
- 日本心臓病学会誌, 2013年09月, 日本語, (一社)日本心臓病学会拡張型心筋症における心臓MRIの遅延造影と心筋血流の低下との関連性の検討
- 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 2011年10月, 日本語空腹時FDG-PETおよび安静時99mTc心筋シンチグラフィーにて活動性炎症が疑われ経過観察しえた心サルコイドーシスの2例
- 核医学, 2011年09月, 日本語活動性炎症が認められる心サルコイドーシス患者におけるステロイド治療の有用性の評価
- 日本心臓病学会誌, 2011年08月, 日本語抗ミトコンドリアM2抗体関連多発性筋炎に合併した慢性心筋炎の1例
- 日本心臓病学会誌, 2011年08月, 日本語3次元心エコー図法の進歩 左室駆出率の低下したnarrow QRS心不全患者にも左室同期不全は存在する 3次元スペックルトラッキング法を用いた検討
- 日本心臓病学会誌, 2011年08月, 日本語CRTレスポンダー・ノンレスポンダーの予測とその対策 新たな展開 心臓再同期療法における3次元スペックルエリアトラッキング法の有用性
- 超音波医学, 2011年04月, 日本語卵円孔に血栓が陥入した急性肺動脈血栓症の一例
- 超音波医学, 2011年04月, 日本語左心耳内血栓を合併した非細菌性血栓性心内膜炎の1例
- 超音波医学, 2011年04月, 日本語虚血性心疾患の局所長軸機能におけるハンドグリップ及びドブタミン負荷の有用性
- 超音波医学, 2011年03月, 日本語重症三尖弁閉鎖不全に対して三尖弁形成術を行い、良好な結果を得た高齢Ebstein奇形の一例
- 超音波医学, 2011年03月, 日本語心エコー図検査が治療方針決定に有用であった左室流出路狭窄の2症例
- 日本内科学会雑誌, 2011年02月, 日本語左室同期不全がQRS幅の拡大を伴う心不全患者の心臓交感神経活性に及ぼす影響
- 核医学, 2010年09月, 日本語糖尿病のアデノシン負荷心筋血流による虚血診断への影響
- 日本心臓病学会誌, 2010年08月, 日本語長期経過を経て再燃し、経過中PETの心集積を認めた慢性心筋炎の一例
- 日本心臓病学会誌, 2010年08月, 日本語重症大動脈弁狭窄症における左室同期不全と左室後負荷の関係
- 超音波医学, 2010年03月, 日本語心機能(ストレイン) 虚血心筋における収縮期心筋ストレインのハンドグリップ負荷に対する反応性 経皮的冠動脈形成術(PCI)前後の検討
- 超音波医学, 2010年03月, 日本語心機能(ストレイン) 重症大動脈弁狭窄症への大動脈弁置換術は、左室同期不全を改善する
- 核医学, 2009年09月, 日本語アデノシン負荷心筋シンチによるCABG後のバイパス法の違いによる術後残存虚血の検討
- 日本心臓病学会誌, 2009年08月, 日本語肺高血圧患者の右心機能評価 2D speckle tracking法による右室心筋strainを用いた検討
- 日本心臓病学会誌, 2009年08月, 日本語心サルコイドーシスの炎症活動性をマルチモダリティにて検討した2症例
- 超音波医学, 2009年05月, 日本語低左心機能を伴う大動脈弁狭窄症の一例
- 超音波医学, 2009年05月, 日本語ドブタミン負荷心エコー図検査が治療法選択に有用であった虚血性心筋症の1例
- Circulation Journal, 2009年04月, 日本語抗精神病薬治療中に発症した慢性心筋炎の一剖検例
- Circulation Journal, 2009年04月, 日本語CPAより蘇生に成功し、ICD植込みを行った冠攣縮性狭心症の一症例
- 心電図, 2008年10月, 日本語心房粗動と非持続性心室頻拍を合併したファブリー病を原因とする拡張相肥大型心筋症の1例
- Circulation Journal, 2008年10月, 日本語心臓再同期療法を施行し術直後より左室拡張能の改善を認めた心ファブリー病の一例
- 核医学, 2008年09月, 日本語安静時99mTc-TF心筋SPECTにおける洗い出し現象は拡張型心筋症での心臓再同期療法の長期効果を予測する
- 日本心臓病学会誌, 2008年08月, 日本語心臓再同期療法を施行した心ファブリー病の一例
- 日本心臓病学会誌, 2008年08月, 日本語心臓再同期療法による局所拡張早期心筋機能の急性期反応は遠隔期左室収縮能改善を予測する
- 超音波医学, 2008年04月, 日本語慢性重症大動脈弁閉鎖不全症患者において術前左室非同期は術後収縮不全と関連する
- Circulation Journal, 2008年04月, 日本語部分肺静脈還流異常症の一例
- 超音波医学, 2008年04月, 日本語大動脈弁閉鎖不全症を契機に診断された巨細胞性動脈炎の一例
- 超音波医学, 2008年04月, 日本語心筋ストレイン分布の評価によるDuchenne型筋ジストロフィーの早期心筋病変の検出について
- 超音波医学, 2008年04月, 日本語拡張型心筋症における後負荷不適合と左室局所心筋の心機能障害の関連性 2D speckle tracking法による検討
- 超音波医学, 2008年03月, 日本語2D speckle tracking法を用いた局所心筋収縮能と心臓再同期療法の有効性に関する検討
- 超音波医学, 2003年左室壁在血栓と僧帽弁逆流を伴ったLoffler心内膜心筋炎の1例
- 超音波医学, 2003年大動脈弁逆流におけるcoronary flow patternの検討
- 超音波医学, 2003年大動脈-右室穿孔を伴った大動脈弁輪膿瘍の1例
- 超音波医学, 2003年両心室ペーシングによる左室dysynchronyの改善に心筋ストレイン法による評価が有用であった1症例
- 核医学, 2003年負荷心筋血流シンチグラフィー正常例における予後予測の検討
- 核医学, 2003年拡張型心筋症における心筋脂肪酸摂取率とβ遮断薬療法による心機能改善との関連性
- 核医学, 2003年急性心筋梗塞治療後のリスクエリアにおける局所心機能回復の予測 安静時心電図同期SPECTと123I-BMIPPイメージングによる検討
- 核医学, 2003年多枝病変を有する急性心筋梗塞における非梗塞領域の虚血評価 ATP負荷心筋血流シンチグラフィーによる検討
- 日本小児循環器学会雑誌, 2003年修正大血管転位症と診断され,19年後に高度左側房室弁逆流症に対して弁置換術を行った成人女性の1例
- 日本内科学会雑誌, 2003年心臓核医学を用いた急性心筋梗塞(AMI)の再灌流療法による局所心機能回復の予測
- Journal of Cardiology, 2003年虚血性心疾患における虚血部局所心筋機能に対する経皮的冠動脈インターベンションの効果 Strain rate imaging法を用いた検討
- Journal of Cardiology, 2003年急性心筋梗塞における再灌流治療後の心機能回復の予測 安静時心電図同期SPECTと123I-BMIPPイメージングによる検討
- Circulation Journal, 2003年著明な全身の動脈硬化病変を有し,MRSAによる感染性大動脈瘤,細菌性心外膜炎を併発した一剖検例
- Circulation Journal, 2003年拡張型心筋症による重症心不全に対し両心室ペーシングが有効であった一例
- Circulation Journal, 2003年子宮筋腫に合併した慢性肺血栓塞栓症の一例
- Circulation journal : official journal of the Japanese Circulation Society, 2002年10月, 日本語, 社団法人日本循環器学会4) 短期間で著明な拡大を認めた心室瘤を合併した下壁心筋梗塞の一症例
- Circulation journal : official journal of the Japanese Circulation Society, 2002年10月, 日本語, 社団法人日本循環器学会88) 中枢神経症状で発症し,S.aureusとCandidaの混合感染が疑われた感染性心内膜炎の一例
- Circulation journal : official journal of the Japanese Circulation Society, 2002年04月, 日本語, 社団法人日本循環器学会138)潰瘍性大腸炎に肺動脈血栓塞栓症を合併した1症例(日本循環器学会 第92回近畿地方会)
- Circulation journal : official journal of the Japanese Circulation Society, 2002年03月, 英語, 社団法人日本循環器学会Contribution of inner and outer halves to transmural wall thickening in the hyperdynamic state using tissue Doppler tracking technique
- 超音波医学, 2002年脳梗塞,髄膜炎を合併した細菌性・真菌性心内膜炎の1例
- Japanese circulation journal, 2001年10月, 日本語, 社団法人日本循環器学会113) 向精神薬の内服加療中に発症した慢性心筋炎の一例(日本循環器学会 第91回近畿地方会)
- Japanese circulation journal, 2001年04月, 日本語, 社団法人日本循環器学会53) 両心室肥大,肺高血圧を呈した心サルコイドーシスの一症例
- Japanese circulation journal, 2000年03月, 日本語, 社団法人日本循環器学会P282 抗凝固療法施行中の心房細動患者における血栓準備状態と経食道心エコー図法によるIntegrated Backscatter値との関係
- Japanese circulation journal, 1999年08月, 日本語, 社団法人日本循環器学会129)特発性拡張型心筋症における心機能著明改善例の予知
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- Japanese circulation journal, 1991年11月, 日本語, 社団法人日本循環器学会拡張型心筋症の家族内発症に関する検討
- Japanese circulation journal, 1991年11月, 日本語, 社団法人日本循環器学会拡張型心筋症の左室流入動態の経時的変化
- Japanese circulation journal, 1990年12月, 日本語, 社団法人日本循環器学会断層心エコー図法による急性心筋梗塞部位の評価 : 冠動脈造影所見との比較
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