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ONO Yuko
University Hospital / Emergency and Critical Care Medicine
Assistant Professor

  • Profile

    I am currently serving as a staff physician and a clinical senior lecturer at the Emergency Department, Kobe University Hospital. I am also conducting the laboratory work, as a postdoctoral researcher at Department of Bioregulation and Pharmacological Medicine, at Fukushima Medical University. My time is divided between researches (both clinical and laboratory); clinical practice; and teaching (medical student, graduate school students, and junior and senior residents). 

    My clinical background is emergency medicine, intensive care medicine, and anesthesiology. My major clinical research interests are: emergency airway management; trauma; emergency surgery; perioperative medicine; and sepsis. My clinical research work have featured in a series of publications [Scand J Trauma Resusc Emerg Med. 2016;24:106, and J Anesth. 2016;30:644-52]. 

    As for the basic research, in order to elucidate the etiology of ICU acquired weakness associated with severe sepsis, I am currently working on mouse sepsis model and established myoblast cell lines. My laboratory research work have featured in a series of publication [ Front Pharmacol. 2022;13:1031906, Sci Rep. 2020 ;10:694, PLoS One. 2017;12:e0182040, and J Pharmacol Sci. 2017;133:276-279]. 

    The majority of my teaching activities take place at Kobe University Hospital. I regularly give 5th year medical school students lectures and practice on endotracheal intubation using simulators. I also teach paramedical students.

    As a board certified acute care physician and a board certified anesthesiologist, I carry out my clinical service at the Emergency Department, Kobe University Hospital. I am also involved in ICU inpatients and clinical supervisory role of junior and senior residents.  

    Integrating these multifaceted activities of clinical and basic science research, clinical service, and teaching, I am striving to develop my academic career as a physician-scientist with expertise in airway management, trauma, and sepsis.

Researcher basic information

■ Research Keyword
  • skeltel muscle myogenesis
  • toll like receptor
  • pharmacology
  • sepsis
  • trauma
  • Airway management
■ Research Areas
  • Life sciences / Healthcare management, medical sociology / epidemiology
  • Life sciences / Cell biology / Cell biology
  • Life sciences / Molecular biology / molecular biology
  • Life sciences / Pharmacology / General Pharmacology
  • Life sciences / Anesthesiology / Anesthesiology/Resuscitation Studies
  • Life sciences / Emergency medicine / Emergency Medicine
■ Committee History
  • Apr. 2024 - Present, The Japan Shock Society, Councilor
  • Aug. 2023 - Present, Kobe University, Kobe, Japan, Clinical laboratory Department Liaison Committee
  • Apr. 2023 - Present, Kobe city medical control council, Kobe city medical control council training committee
  • Jan. 2023 - Present, Japanese Association for Acute Medicine, Technical terminology committees
  • Apr. 2021 - Present, Kobe University, Kobe, Japan., CVC hands-on seminar working group
  • Apr. 2020 - Present, Kobe University, Kobe, Japan, Kusunoki district internet network committee
  • Apr. 2020 - Present, Kobe University, Kobe, Japan., Diagnosis Procedure Combination (DPC) coding Committee
  • Apr. 2020 - Present, Kobe University, Kobe, Japan, Insurance Committee
  • Apr. 2020 - Present, Kobe University, Kobe, Japan, Operating Room Liaison Committee
  • Apr. 2024 - Apr. 2025, Kobe University, Kobe, Japan, Clinical study management committee, clinical study manager
  • Apr. 2023 - Apr. 2025, Hanshin Tamba region, medical control council, Hanshin Tamba region, medical control council, Post-verification committee
  • Mar. 2025 - Mar. 2025, Kobe University, Kobe, Japan, Common achievement tests examination question preparation committee, Member Create 1 examination question (Anaphylaxis/anaphylaxis shock)
  • Feb. 2024 - Mar. 2025, The Japanese Society of Intensive Care Medicine, The 52nd annual meeting of the Japanese Society of Intensive Care Medicine, Academic program committee
  • Apr. 2022 - Mar. 2025, Japan Endotoxin and Innate Immunity Society, Executive director
  • Mar. 2024 - Oct. 2024, Special Issue Editors, Current Therapies for Trauma and Surgical Critical Care, A special issue of Medicina (ISSN 1648-9144):https://www.mdpi.com/journal/medicina/special_issues/Z29090RB1M, Special Issue Editors, https://researchmap.jp/windmill/committee_memberships/47226456/edit
  • Jul. 2024 - Jul. 2024, Kobe University, Kobe, Japan, Graduate examination question preparation committee, Member. Create 10 examination questions
  • Aug. 2023 - Apr. 2024, The 2nd annual meeting of the ERAS® Japan society, Executive director
  • Nov. 2023 - Nov. 2023, Frontiers in Education, section Educational Psychology, Associate editor
  • Jul. 2023 - Jul. 2023, Kobe University, Kobe, Japan, Graduate examination question preparation committee, Member. Create 7examination questions
  • Jul. 2022 - Jul. 2022, Kobe University, Kobe, Japan, Graduate examination question preparation committee, Member. Create 3 examination questions
  • Oct. 2021 - Jun. 2022, Kobe University, Kobe, Japan, Employee education working group
  • Mar. 2021 - Mar. 2021, Kobe University, Kobe, Japan, Common achievement tests examination question preparation committee, Member Create 1 examination question (Cardiopulmonary resuscitation)
  • Aug. 2020 - Aug. 2020, Kobe University, Kobe, Japan, Graduate examination question preparation committee, Member Create 3 examination questions
  • Mar. 2020 - Mar. 2020, Kobe University, Kobe, Japan, Common achievement tests examination question preparation committee, Member
  • Oct. 2019 - Mar. 2020, Kobe University, Kobe, Japan, Disaster Preparedness Working Group, Member
  • Apr. 2018 - Mar. 2019, Fukushima Medical University, Fukushima, Japan, Supporting Staff, Office for Gender Equality Support
  • Apr. 2016 - Mar. 2019, Fukushima Medical University, Fukushima, Japan, Clinical Pathological Conference Committee, Committee member

Research activity information

■ Award
  • May 2025 The 39th annual meeting of the Japanese association for the surgery of trauma., Special Thesis Award, Impact of seat position on survival outcomes and anatomically specific severe injury patterns in four-wheeled motor vehicle accidents.
    Tasuku Uzawa, Yuko Ono* (corresponding author), Jun Sugiyama, Kazushi Takayama, Nobuto Nakanishi, Kazuaki Shinohara, Joji Kotani
    Japan society

  • May 2025 The 39th Annual Meeting of the Japanese Shock Society, The president’s award, Visualization of autophagy activation in skeletal muscle during sepsis.
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    International society

  • Nov. 2024 The Japanese Endotoxin and Innate Immunity Society, The best performance award 2024, Elucidation of the mechanism of sepsis associated skeletal muscle atrophy and pharmacological treatment
    Yuko Ono
    International academic award

  • Jul. 2024 The 30th annual conference on cytokine research in surgery and critical care, The best presentation award, The IL/STAT3 pathway activation and the sepsis associated skeletal muscle atrophy
    Yuko Ono, Masafumi Saito, Jun Sugiyama, Kazushi Takayama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    Japan society

  • Apr. 2024 Journal of Clinical Medicine, Exceptional reviewer 2024
    Yuko Ono
    Journal of Clinical Medicine Exceptional Reviewers List 2024 https://www.mdpi.com/about/announcements/8269 This program was designed to recognize and honor scholars who have delivered consistently exceptional review reports to Journal of Clinical Medicine. Committed to fostering rigorous research and promoting knowledge exchange, the Journal of Clinical Medicine (JCM, ISSN: 2077-0383) recognizes the significant role our reviewers play in maintaining the quality and integrity of the articles we publish. According to surveys conducted in 2023, 91% of our authors rate the peer review as good or excellent, thanks to our pool of excellent reviewers.
    Official journal

  • Nov. 2023 the Japanese Association for Acute Medicine, The best scientific paper award of the Japanese Association for Acute Medicine The best-case report award, Intravenous idarucizumab for dabigatran overdose: association between plasma dabigatran concentration and coagulation profile (in Japanese). JJAAM. 2023; 34: 6-11
    Kaneda K, Ono Y*(Corresponding author), Miyazaki Y, Toyama K, Yamada I, Inoue S, Kotani J
    Japan society

  • Jul. 2023 The 29th annual conference on cytokine research in surgery and critical care, The president's award, Awarded presentation: Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani. STAT3 signaling as a therapeutic target for the thermal burn-induced skeletal muscle wasting.
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani

  • Jun. 2023 Kobe University, The excellent young investigator award (2023)
    Yuko Ono
    卓越した業績を挙げた若手研究者が、将来神戸大学の研究リーダーとして活躍することを期待し、また若手研究者らの活性化を図るため、その研究結果・積み重ねに対して表彰を行う賞
    International academic award

  • Jun. 2023 The 70th Annual Meeting of the Japanese Society of Anesthesiologists, Kobe, Japan., Award for best presentation (Emergency medicine and ICU), C188-9, a specific inhibitor of STAT3 signaling, ameliorates thermal burn-induced skeletal muscle wasting in mice.
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    Japan society

  • Oct. 2021 16th Meeting of the International Endotoxin and Innate Immunity Society & 26th Japanese Endotoxin and Innate Immunity Society, Award for outstanding presentation, Thermal burn injury increases STAT3 signaling pathway activation, following to induce skeletal muscle atrophy in mice.
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Yusuke Miyazaki, Naoki Moriyama, Yoshihisa Fujinami, Shigeaki Inoue, Joji Kotani
    International society

  • Jul. 2021 PLOS ONE, The top 10% most cited PLOS ONE papers published in 2017, Awarded paper: Ono Y, Sakamoto K. Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α. PLoS One. 2017;12:e0182040.
    Ono Y, Sakamoto K
    Official journal

  • Mar. 2021 Scientific Reports, The top 100 downloaded cell and molecular biology papers for Scientific Reports in 2020, Awarded paper: Ono Y, et al. TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice. Sci Rep. 2020;10:694.
    Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J
    Official journal

  • Mar. 2021 Japanese Association for Medical Simulation, Best paper award, Ono Y, et al. Lower maximum forces on oral structures when using gum-elastic bougie than when using endotracheal tube and stylet during both direct and indirect laryngoscopy by novices: a crossover study using a high-fidelity simulator. BMC Emerg Med. 2020;20:34.
    Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Shigeaki Inoue, Joji Kotani
    Japan society

  • Feb. 2020 The 24th Annual Meeting of Japan Society of Critical Care for Endotoxemia, Award for best presentation, Lipopolysaccharide inhibits phosphorylation of Akt and S6k in mice skeletal muscle
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yoshihisa Fujinami, Shigeaki Inoue, Joji Kotani.
    Japan society

  • Jun. 2019 The 66th Annual Meeting of the Japanese Society of Anesthesiologists, Award for best presentation, TAK-242, a specific inhibitor of Toll like receptor 4 signaling ameliorates sepsis induced muscle wasting in mice.
    Yuko Ono, Yuko Maejima, Kazuho Sakamoto, Shoichiro Horita, Kenju Shimomura, Shigeaki Inoue, Joji Kotani
    International academic award

  • 08 Jun. 2017 the Japanese Society of Anesthesiologists, Excellent presentation session, The 64th Annual Meeting of the Japanese Society of Anesthesiologists, Lipopolysaccharide Inhibits Myogenic Differentiation of C2C12 Myoblasts Through the Toll-like Receptor 4 Nuclear Factor-κB Signaling Pathway
    Yuko Ono, Kazuho Sakamoto
    International academic award

  • May 2015 The Japanese society of Anesthesiologists, The 62nd Japanese society of Anesthesiologists, Excellent presentation session, Emergency endotracheal intubation-related adverse events in bronchial asthma exacerbation: can anesthesiologists attenuate the risk?
    Ono Y, Kikuchi H, Hashimoto K, Sasaki T, Tase C, Shinohara K
    International academic award

  • Jun. 2014 The 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine, Tohoku Branch, Award for best presentation,The 23rd Annual Meeting of the Japanese Society of Intensive Care Medicine, Tohoku Branch, Massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case report
    Yuko Ono
    Japan society

■ Paper
  • Inada M., Ono Y*(corresponding author)., Yamada I., Kotani J.
    Jun. 2025, Journal of Japanese Society for Critical Care Medicine, 39, 31 - 38, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Tasuku Uzawa, Jun Sugiyama, Nozomi Tomita, Takeyasu Kakamu, Tokiya Ishida, Joji Kotani, Kazuaki Shinohara
    Road traffic accidents are a global health concern. K-car vehicles, also known as "mini vehicles," are defined as those having an engine displacement <660 cc, vehicle length <3.4 m, width <1.48 m, and height <2.0 m. K-cars have become increasing popular not only in Japan but also in other countries. Compared with standard vehicles, the occupant space of a K-car vehicle is considerably smaller; thus, passengers may be more vulnerable to the external forces generated in a collision, which in turn can lead to deformation of the occupant space and less protection against injuries. However, data are scarce regarding whether K-car vehicles are related to poorer survival outcomes and severe trauma. We conducted a retrospective cohort study involving patients who were injured in four-wheeled vehicle accidents between 2002 and 2023 and admitted to a community teaching hospital in Japan. The vehicle configuration was divided into standard and K-car vehicles. The primary endpoint was in-hospital mortality. Other outcomes included severe trauma, defined as Injury Severity Score (ISS) >15, and anatomically specific severe injury of the head and neck, chest, abdomen, pelvis, and extremities, defined as Abbreviated Injury Scale score ≥3. Of 5331 eligible patients, 2384 (44.7%) were K-car vehicle occupants. In propensity score-matched analysis with 1947 pairs, we observed an increase for in-hospital mortality in the K-car vehicle group (2.6% vs. 4.0%, odds ratio 1.53, 95% confidence interval 1.07–2.19). Compared with standard vehicles, K-car vehicles were associated with a greater risk of severe trauma and serious injuries of the head and neck, chest, abdomen, pelvis, and extremities. These study data should be used to encourage vehicle occupants and automobile manufacturers to consider objective facts regarding the safety of vehicles in a traffic accident.
    Public Library of Science (PLoS), Feb. 2025, PLOS ONE, 20(2) (2), e0318748 - e0318748, Japanese, No password, International magazine
    [Refereed]
    Scientific journal

  • Yoshihisa Fujinami, Masafumi Saito, Yuko Ono, Masaya Akashi, Shigeaki Inoue, Joji Kotani
    Feb. 2025, International Journal of Molecular Sciences, 26(5) (5), 1894, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Chan M, Ono Y, Yamada I, Kotani J
    Corresponding, Aug. 2024, The Japanese journal of acute medicine, 48(8) (8), 1003 - 1010, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • What do increased-T cells do in the brain after sepsis?
    Masafumi Saito, Naoki Moriyama, Yuko Ono, Joji Kotani
    The New Science Co., Ltd., Jul. 2024, The Cell (in Japanese), 56(8) (8), 613 - 617, Japanese, Domestic magazine
    Scientific journal

  • Yuko Ono, Kauzaki Shinohara, Tokiya Ishida, Isamu Yamada, Joji Kotani
    Lead, Wiley, Jun. 2024, Acute Medicine & Surgery, 11(1) (1), e968 - e968, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Joji Kotani
    May 2024, Endotoxin and Innate Immunity, 25, 37 - 41, Japanese, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Joji Kotani
    Lead, Mar. 2024, Endotoxin and Innate Immunity, 24, 9 - 13, Japanese, No password
    [Refereed]
    Scientific journal

  • Kenji Takata, Yuko Ono, Kazushi Takayama, Isamu Yamada, Joji Kotani
    Corresponding, Mar. 2024, Journal of Japanese Society for Critical Care Medicine, 38, 1 - 12, Japanese, No password, Domestic magazine
    [Refereed]

  • Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Jun Sugiyama, Shigeaki Inoue, Joji Kotani
    Endotracheal intubation (ETI) is a common and crucial intervention. Whether the performance of ETI differs according to the sex of the laryngoscopist remains unclear. The aim of this study was to assess sex disparities in markers of ETI performance among novices using a high-fidelity simulator. This prospective observational study was conducted from April 2017 to March 2019 in a public medical university. In total, 209 medical students (4th and 5th grade) without clinical ETI experience were recruited. Of the 209 students, 64 (30.6%) were female. The participants used either a Macintosh direct laryngoscope or C-MAC video laryngoscope in combination with a stylet or gum-elastic bougie to perform ETI on a high-fidelity simulator. The primary endpoint was the maximum force applied on the maxillary incisors during laryngoscopy. The secondary endpoint was the time to ETI. The implanted sensors in the simulator automatically quantified the force and time to ETI. The maximum force applied on the maxillary incisors was approximately 30% lower in the male than female group for all laryngoscopes and intubation aids examined (all P < 0.001). Similarly, the time to ETI was approximately 10% faster in the male than female group regardless of the types of laryngoscopes and intubation aids used (all P < 0.05). In this study, male sex was associated with a lower maximum force applied on the maxillary incisors during both direct and indirect laryngoscopy performed by novices. A clinical study focusing on sex differences in ETI performance is needed to validate our findings. Keywords: Airway-related adverse events; Definitive airway management; Laryngoscopy; Medical student; Sex gap.
    Feb. 2024, Kobe J Med Sci, 69(4) (4), E151 - E158, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Tokiya Ishida, Nozomi Tomita, Kazushi Takayama, Takeyasu Kakamu, Joji Kotani, Kazuaki Shinohara
    Suicide is an increasingly important public healthcare concern worldwide. Studies examining the effect of attempted suicide on clinical outcomes among patients with trauma are scarce. We conducted a retrospective cohort study at a community emergency department in Japan. We included all severely injured patients with an Injury Severity Score > 15 from January 2002 to December 2021. The primary outcome measure was in-hospital mortality. The other outcome of interest was hospital length of stay. One-to-one propensity score matching was performed to compare these outcomes between suicide attempt and no suicide attempt groups. Of the 2714 eligible patients, 183 (6.7%) had trauma caused by a suicide attempt. In the propensity score-matched analysis with 139 pairs, the suicide attempt group showed a significant increase in-hospital mortality (20.9% vs. 37.4%; odds ratio 2.27; 95% confidence intervals 1.33–3.87) compared with the no suicide attempt group. Among survivors, the median hospital length of stay was significantly longer in the suicide attempt group than that in the no suicide attempt group (9 days vs. 12 days, p = 0.0076). Because of the unfavorable consequences and potential need for additional healthcare, increased attention should be paid to patients with trauma caused by a suicide attempt.
    MDPI AG, Jan. 2024, International Journal of Environmental Research and Public Health, 21(2) (2), 121 - 121, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Minnie Chan, Yuko Ono, Joji Kotani, Takashi Itou, Yoshikazu Kinoshita
    Corresponding, Oct. 2023, Clin Case Rep, 11, e8108, English, No password, International magazine
    [Refereed]

  • Sugimoto T, Ono Y, Ando Y, Seki T, Yamada I, Kotani J
    Corresponding, Oct. 2023, Journal of Japanese Society for Critical Care Medicine, 37, 59 - 65, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • Nobuto Nakanishi, Shigeaki Inoue, Yuko Ono, Jun Sugiyama, Kazushi Takayama, Yuta Arai, Kensuke Nakamura, Jun Oto, Joji Kotani
    Elsevier BV, Oct. 2023, Clinical Nutrition ESPEN, 57, 569 - 574, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Inada M, Ono Y, Yamada I, Kotani J
    Corresponding, Aug. 2023, Journal of Japanese Society for Critical Care Medicine, 37, 41 - 47, Japanese, No password, Domestic magazine
    [Refereed]

  • Ono Y, Saito M, Shimomura K, Shinohara K, Yamada N, Iwasaki Y, Inoue S, Kotani J
    Aug. 2023, Kobe J Med Sci, 69(2) (2), E64 - E78, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Shigeaki Inoue, Joji Kotani
    The ongoing coronavirus 2019 (COVID-19) pandemic has increased the need for healthcare professionals to perform emergency endotracheal intubation (ETI) in patients with COVID-19-related respiratory failure outside of the operating room. Difficult airways and severe airway-related adverse events occur much more frequently in such settings due to limited time and resources as well as the patient’s reduced physiological reserve. The gum elastic bougie (GEB) intubation tube is an inexpensive, simple, and readily transportable aid to intubation, but its effectiveness in emergency airway management has not been comprehensively evaluated in recent years. Here, we performed a literature review and have updated the available evidence on the utility of GEB in emergency airway management. After a systematic MEDLINE search, we identified 36 relevant reports that compared GEB with alternative airway management approaches in a variety of real-world and simulated settings. In most studies, GEB increased the first-pass ETI success rate and decreased the force applied on the tongue and incisors during laryngoscopy. GEB also increased the speed, safety, and reliability of emergency cricothyrotomy. Conflicting results were obtained in studies examining GEB use for ETI during cardiopulmonary resuscitation, and other special circumstances such as selective lung ventilation, the presence of vomitus, and the use of personal protective equipment. These results suggest that GEB use could be expanded beyond difficult airways and rescue after failed ETI attempts, but further studies will be necessary to determine the utility of GEB under special conditions. Because fatal airway-related adverse events can in part be attributed to limited accessibility of proper airway management equipment, devices such as GEB may increase successful outcomes, especially under the overwhelmingly challenging conditions imposed by the COVID-19 pandemic.
    MRE Press, Aug. 2023, Signa Vitae, 19(5) (5), 29 - 37, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Emergency Airway Management Outside the Operating Room in the Era of COVID-19
    Ono Y, Shinohara K, Inoue S, Kotani J
    Jul. 2023, The Journal of Japan Society for Clinical Anesthesia, 43(4) (4), 311 - 315, Japanese, No password, Domestic magazine
    [Refereed]

  • Naoki Moriyama, Masafumi Saito, Yuko Ono, Kimihiro Yamashita, Takashi Aoi, Joji Kotani
    Overactivated microglia play a key role in sepsis-associated encephalopathy (SAE), although the involvement of T cells is unclear. γδT cells in the brain and meninges regulate normal fear responses via interleukin (IL)-17 in healthy mice. In our sepsis model, the mice showed exacerbated anxious behavior at 10 days post-induction (dpi). At 8 dpi, IL-17 mRNA was significantly upregulated in the brains of septic mice compared with those of control mice. Simultaneously, the number of γδT cells increased in the brains of septic mice in a severity-dependent manner. Additionally, IL-17-producing γδT cells, expressing both the C-X-C motif receptor (CXCR) 6 and the C-C motif receptor (CCR) 6, increased in mice brains, dependent on the severity of sepsis. The frequency of γδT cells in the meninges fluctuated similarly to that in the brain, peaking at 8 dpi of sepsis. Behavioral tests were performed on septic mice after the continuous administration of anti-γδTCR (α-γδTCR) or anti-IL-17A (α-IL-17A) antibodies to deplete the γδT cells and IL-17A, respectively. Compared with IgG-treated septic mice, α-γδTCR- and α-IL-17A-treated septic mice showed suppressed microglial activation and improvements in anxious behavior. These results suggested that CCR6+CXCR6+ IL-17-producing γδT cells in the brain and meninges promote the exacerbation of SAE and sepsis-induced psychological disorders in mice.
    MDPI AG, Jun. 2023, Journal of Clinical Medicine, 12(13) (13), 4309 - 4309, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono
    Physician-scientistとは,臨床現場で医師として働きながら基礎医学研究を行い,基礎と臨床の橋渡しをする研究者である.救命救急の臨床現場で日々患者に向き合い,真剣に臨床に取り組んでいると,ふと「この生命現象はなぜ起きるのだろう」と疑問が湧いてくる事がある.第一線の臨床現場から出てくるこのような疑問こそが,真に重要な「問い」であり,この「問い」の検証こそがphysician-scientistが行わなければならない研究である.基礎医学と実臨床を橋渡しするためには,両方の世界を知っていなければならない.救命救急医がやらなければならない基礎研究は,確実に存在している.  筆者は救命救急医としてのキャリアを積むなかで,「なぜ重症患者に骨格筋萎縮が発生するのだろう」という臨床的な疑問を抱くようになった.この疑問を解決するために,薬理学の大学院に入学し基礎研究を進め,この「問い」に自分なりの回答を見出すことができた.そこで得た経験と,仲間と「一緒に大切な事を成し遂げた」経験は,自分にとってかけがえのない財産である.  基礎研究の醍醐味は,分子レベルから疾患のメカニズムを明らかにし,その本態にせまり,このような「問い」にクリアに答えることにある.臨床研究よりもデザインの制約は少なく,自由度が高い.さらに処置群と対照群の背景をそろえることができるため,きれいな結果が期待できる.  しかし基礎研究の大部分は,実験室での地道な手作業に費やされ,時間も費用も労力もかかる.多大なコストを払って行った実験が結果にたどり着かず,失意を味わうこともある.筆者自身「こんなこと,やめてやる」と思ったことは,1度や2度ではない.しかしそれでもなお,地道な努力や苦労の結果得た,「新しい発見」の喜びは何にも代えがたいものである.  輝かしい「救命医療の未来」を作るために,そのようなphysician-scientistの存在はかかせない.さて,あなたにとってphysician-scientistは良い選択だろうか? 本稿では,筆者の経験を踏まえ判断材料を提供する.
    Apr. 2023, Journal of Japanese Society for Critical Care Medicine, 37, 14 - 22, Japanese, No password, Domestic magazine
    [Refereed][Invited]
    Scientific journal

  • How biological invasion causes skeletal muscle atrophy (in Japanese)
    Yuko Ono
    Lead, 2023, Shock: Journal of the Japan Shock Society, 37, 30 - 35, Japanese, No password, Domestic magazine
    [Refereed]

  • Jun Sugiyama, Shigeaki Inoue, Masami Inada, Yusuke Miyazaki, Nobuto Nakanishi, Yoshihisa Fujinami, Masafumi Saito, Yuko Ono, Kazushige Toyama, Futoshi Toda, Tohru Shirotsuki, Soushi Shiotani, Joji Kotani
    Wiley, Jan. 2023, Acute Medicine & Surgery, 10(1) (1), English, No password
    [Refereed]
    Scientific journal

  • Takashi Sugimoto, Yuko Ono, Eisuke Ueshima, Keigo Matsushiro, Isamu Yamada, Joji Kotani
    Background: The kidneys are one of the organs most commonly affected by blunt trauma; however, the anatomical variations that predispose kidney injury are poorly understood. Case Presentation: An 80-year-old Japanese woman with lumber scoliosis was brought to our hospital because of severe flank pain after a minor fall at home. Contrast-enhanced computed tomography showed a severe left kidney laceration at the level of an acute angle in the vertebral column caused by scoliosis. Extravasation of contrast medium from the left renal artery branches was also noted. Selective arterial embolization achieved hemostasis. The patient was transferred to a rehabilitation facility without sequelae. Conclusion: Patients with scoliosis could be at higher risk of severe kidney laceration because of intrusion of the vertebral column into the retroperitoneal space. Therefore, even after low-impact trauma, active exploration for kidney injury could be warranted in patients with spinal curvature disorders.
    Corresponding, Wiley, Jan. 2023, Acute Medicine & Surgery, 10(1) (1), e816, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Kaneda K, Ono Y, Miyazaki Y, Toyama K, Yamada I, Inoue S, Kotani J
    Dabigatran is an oral direct thrombin inhibitor with increasing recent use. However, information on changes in dabigatran plasma concentrations and coagulation profiles following overdose is limited. Here, we report the case of a patient with a dabigatran overdose who was treated with the specific dabigatran monoclonal antibody idarucizumab. A 71–year–old Japanese woman ingested 7,480mg of dabigatran in a suicide attempt. Her plasma dabigatran level 4h after ingestion was 4,217ng/mL (therapeutic concentration 100–400ng/mL). The activated partial thromboplastin time (APTT) was 160.3s and the prothrombin time–international normalized ratio (PT–INR) was 9.46. Plasma dabigatran levels decreased after intravenous administration of idarucizumab 5g, and APTT and PT–INR were normalized, with robust correlations between plasma dabigatran and APTT (R2=0.9898) and PT–INR (R2=0.9998). The patient was discharged home without sequela on day 9. In this case, idarucizumab safely and effectively reversed plasma dabigatran levels >40 times higher than the therapeutic plasma concentration. Notably, the patient’s coagulation profile was positively correlated with plasma dabigatran concentrations. This case clarifies the pharmacokinetic and coagulation profiles following dabigatran overdose, and suggests that plasma dabigatran concentrations can be estimated by common blood coagulation tests.
    Corresponding, Wiley, Jan. 2023, Nihon Kyukyu Igakukai Zasshi: Journal of Japanese Association for Acute Medicine, 34(1) (1), 6 - 11, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yuko Maejima, Shingen Misaka, Kenju Shimomura, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    Burn injury is the leading cause of death and disability worldwide and places a tremendous economic burden on society. Systemic inflammatory responses induced by thermal burn injury can cause muscle wasting, a severe involuntary loss of skeletal muscle that adversely affects the survival and functional outcomes of these patients. Currently, no pharmacological interventions are available for the treatment of thermal burn-induced skeletal muscle wasting. Elevated levels of inflammatory cytokines, such as interleukin-6 (IL-6), are important hallmarks of severe burn injury. The levels of signal transducer and activator of transcription 3 (STAT3)—a downstream component of IL-6 inflammatory signaling—are elevated with muscle wasting in various pro-catabolic conditions, and STAT3 has been implicated in the regulation of skeletal muscle atrophy. Here, we tested the effects of the STAT3-specific signaling inhibitor C188-9 on thermal burn injury-induced skeletal muscle wasting in vivo and on C2C12 myotube atrophy in vitro after the administration of plasma from burn model mice. In mice, thermal burn injury severity dependently increased IL-6 in the plasma and tibialis anterior muscles and activated the STAT3 (increased ratio of phospho-STAT3/STAT3) and ubiquitin-proteasome proteolytic pathways (increased Atrogin-1/MAFbx and MuRF1). These effects resulted in skeletal muscle atrophy and reduced grip strength. In murine C2C12 myotubes, plasma from burn mice activated the same inflammatory and proteolytic pathways, leading to myotube atrophy. In mice with burn injury, the intraperitoneal injection of C188-9 (50 mg/kg) reduced activation of the STAT3 and ubiquitin-proteasome proteolytic pathways, reversed skeletal muscle atrophy, and increased grip strength. Similarly, pretreatment of murine C2C12 myotubes with C188-9 (10 µM) reduced activation of the same inflammatory and proteolytic pathways, and ameliorated myotube atrophy induced by plasma taken from burn model mice. Collectively, these results indicate that pharmacological inhibition of STAT3 signaling may be a novel therapeutic strategy for thermal burn-induced skeletal muscle wasting.
    Frontiers Media SA, Dec. 2022, Frontiers in Pharmacology, 13, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Keishi Nawata, Nobuto Nakanishi, Shigeaki Inoue, Keibun Liu, Masafumi Nozoe, Yuko Ono, Isamu Yamada, Hajime Katsukawa, Joji Kotani
    Muscle mass is an important factor for surviving an illness. Ultrasound has gained increased attention as a muscle mass assessment method because of its noninvasiveness and portability. However, data on the frequency of ultrasound-based muscle mass assessment are limited, and there are some barriers to its implementation. Hence, a web-based cross-sectional survey was conducted on healthcare providers in Japan, which comprised four parts: 1) participant characteristics; 2) general muscle mass assessment; 3) ultrasound-based muscle mass assessment; and 4) the necessity of, interest in, and barriers to its implementation. Necessity and interest were assessed using an 11-point Likert scale, whereas barriers were assessed using a 5-point Likert scale, in which “Strongly agree” and “Agree” were counted for the analysis. Of the 1,058 responders, 1,026 participants, comprising 282 physicians, 489 physical therapists, 84 occupational therapists, 120 nurses, and 51 dieticians, were included in the analysis. In total, 93% of the participants were familiar with general muscle mass assessment, and 64% had conducted it. Ultrasound-based muscle mass assessment was performed by 21% of the participants. Necessity and interest scored 7 (6–8) and 8 (7–10), respectively for ultrasound-based muscle mass assessment. The barriers to its implementation included lack of relevant education (84%), limited staff (61%), and absence of fixed protocol (61%). Regardless of the necessity of and interest in ultrasound-based muscle mass assessment, it was only conducted by one-fifth of the healthcare providers, and the most important barrier to its implementation was lack of education.
    Public Library of Science (PLoS), Nov. 2022, PLOS ONE, 17(11) (11), e0276855 - e0276855, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Nobuto Nakanishi, Yuko Ono, Yusuke Miyazaki, Naoki Moriyama, Kazumichi Fujioka, Kimihiro Yamashita, Shigeaki Inoue, Joji Kotani
    Background Sepsis-induced muscle atrophy leads to prolonged physical dysfunction. Although the interaction of muscle atrophy and macrophage has been reported in sepsis, the role of neutrophils in muscle atrophy has not been thoroughly investigated. This study sought to investigate the long-term changes in muscle-localized neutrophils after sepsis induction and their possible role in sepsis. Methods Sepsis was induced in seven-week-old male C57BL/6J mice 8-12 (cecal slurry [CS] model) via intraperitoneal injection of 1 mg/g cecal slurry. The percentage change in body weight and grip strength was evaluated. The tibialis anterior muscles were dissected for microscopic examination of the cross-sectional area of myofibers or Fluorescence-activated cell sorting (FACS) analysis of immune cells. These changes were evaluated in the following conditions: (1) Longitudinal change until day 61, (2) CS concentration-dependent change on day 14 at the low (0.3 mg/g), middle (1.0 mg/g), and high (2.0 mg/g) concentrations, and (3) CS mice on day 14 treated with an anti-Ly6G antibody that depletes neutrophils. Results Body weight and grip strength were significantly lower in the CS model until day 61 (body weight: 123.1% ± 1.8% vs. 130.3% ± 2.5%, p = 0.04; grip strength: 104.5% ± 3.8% vs. 119.3% ± 5.3%, p = 0.04). Likewise, cross-sectional muscle area gradually decreased until day 61 from the CS induction (895.6 [606.0–1304.9] μm2 vs. 718.8 [536.2–937.0] μm2, p &lt; 0.01). The number of muscle-localized neutrophils increased from 2.3 ± 0.6 cell/mg on day 0 to 22.2 ± 13.0 cell/mg on day 14, and decreased thereafter. In terms of CS concentration–dependent change, cross-sectional area was smaller (484.4 ± 221.2 vs. 825.8 ± 436.2 μm2 [p &lt; 0.001]) and grip strength was lower (71.4% ± 12.8% vs. 116.3% ± 7.4%, p = 0.01) in the CS High group compared with the control, with increased neutrophils (p = 0.03). Ly6G-depleted mice demonstrated significant increase of muscle cross-sectional area and grip strength compared with control mice (p &lt; 0.01). Conclusions Sepsis causes infiltration of neutrophils in muscles, leading to muscle atrophy and weakness. Depletion of neutrophils in muscle reverses sepsis-induced muscle atrophy and weakness. These results suggest that neutrophils may play a critical role in sepsis-induced muscle atrophy and weakness.
    Frontiers Media SA, Oct. 2022, Frontiers in Immunology, 13, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Sepsis and Cytokine Storm (in Japanese with English abstract)
    Ono Y, Saito M, Inoue S, Kotani J
    Lead, Oct. 2022, Japanese Journal of Intensive Care Medicine, 46(10) (10), 649 - 657, Japanese, No password, Domestic magazine
    [Refereed][Invited]
    Scientific journal

  • Yuko Ono, Eisuke Ueshima, Nobuto Nakanishi, Kazuaki Shinohara, Isamu Yamada, Joji Kotani
    Abstract Background Thyrocervical trunk rupture is an unusual, but critical, complication associated with central venous catheter (CVC) placement. The management of this complication has not been fully determined because it is rare. Case presentation A 53-year-old Japanese woman with anorexia nervosa developed refractory ventricular fibrillation. After returning spontaneous circulation, a CVC was successfully placed at the initial attempt in the right internal jugular vein using real-time ultrasound guidance. Immediately after CVC placement, she developed enlarging swelling around the neck. Contrast-enhanced computed tomography showed massive contrast media extravasation around the neck and mediastinum. Brachiocephalic artery angiography showed a “blush” appearance of the ruptured right thyrocervical trunk. After selective arterial embolization with 33% N-butyl-2-cyanoacrylate, the extravasation completely disappeared and hemostasis was achieved. Conclusion Our findings suggest that severe vascular complications arising from CVC placement can occur in patients with a fragile physiological state. Endovascular embolization is an effective treatment for such complications.
    Springer Science and Business Media LLC, Sep. 2022, JA Clinical Reports, 8(1) (1), 74 - 74, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Shigeaki Inoue, Nobuto Nakanishi, Jun Sugiyama, Naoki Moriyama, Yusuke Miyazaki, Takashi Sugimoto, Yoshihisa Fujinami, Yuko Ono, Joji Kotani
    Post-intensive care syndrome (PICS) comprises physical, mental, and cognitive disorders following a severe illness. The impact of PICS on long-term prognosis has not been fully investigated. This study aimed to: (1) clarify the frequency and clinical characteristics of PICS in sepsis patients and (2) explore the relationship between PICS occurrence and 2-year survival. Patients with sepsis admitted to intensive care unit were enrolled. Data on patient background; clinical information since admission; physical, mental, and cognitive impairments at 3-, 6-, and 12-months post-sepsis onset; 2-year survival; and cause of death were obtained from electronic medical records and telephonic interviews with patients and their families. At 3 months, comparisons of variables were undertaken in the PICS group and the non-PICS group. Among the 77 participants, the in-hospital mortality rate was 11% and the 2-year mortality rate was 52%. The frequencies of PICS at 3, 6, and 12 months were 70%, 60%, and 35%, respectively. The 2-year survival was lower in the PICS group than in the non-PICS group (54% vs. 94%, p < 0.01). More than half of the survivors had PICS at 3 and 6 months after sepsis. Among survivors with sepsis, those who developed PICS after 3 months had a lower 2-year survival.
    MDPI AG, Sep. 2022, Journal of Clinical Medicine, 11(18) (18), 5257 - 5257, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Naoki Matsunaga, Takuya Okada, Yuko Ono, Keigo Matsushiro, Koji Sasaki, Tomoyuki Gentsu, Eisuke Ueshima, Keitaro Sofue, Masato Yamaguchi, Koji Sugimoto, Takamichi Murakami
    Abstract Background Spinal fractures rarely cause hemothorax, and no treatment consensus has been reached. Conservative treatment is generally selected in cases without arterial injury, but there have been some reports of uncontrolled bleeding. Here we report a case of hemothorax caused by spinal fracture without arterial injury treated with transcatheter arterial embolization. Case presentation An 88-year-old Japanese woman with back pain was diagnosed with hemothorax due to bleeding from an unstable fracture of the tenth thoracic vertebra. Contrast-enhanced computed tomography revealed no obvious arterial injury. We performed transcatheter arterial embolization of the bilateral tenth intercostal arteries to prevent rebleeding. The hemothorax did not worsen until surgical spinal fixation 9 days post-transcatheter arterial embolization, and she was discharged 30 days after admission. Conclusion Transcatheter arterial embolization for hemothorax caused by spinal fractures without obvious arterial injury may be a useful bridge to spinal fixation.
    Springer Science and Business Media LLC, Sep. 2022, Journal of Medical Case Reports, 16(1) (1), English, No password, International magazine
    [Refereed]
    Scientific journal

  • Fulminant type 1 diabetes mellitus with ketoacidosis after intravenous administration of nivolumab: Review of case reports.
    Yosuke Matsuno, Yuko Ono, Tadayuki Shoji, Keisuke Kaneda, Yusuke Miyazaki, Tuneyoshi Seki, Kazushige Toyama, Isamu Yamada, Shigeaki Inoue, Joji Kotani
    Corresponding, Sep. 2022, The Japanese journal of acute medicine, 46(9) (9), 1121 - 1127, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • Masafumi Saito, Yoshihisa Fujinami, Yuko Ono, Kimihiro Yamashita, Shigeaki Inoue, Joji Kotani
    Japanese Society for Surgical Metabolism and Nutrition, Aug. 2022, The Japanese Journal of SURGICAL METABOLISM and NUTRITION, 56(4) (4), 155 - 159, Japanese, No password, Domestic magazine
    Scientific journal

  • Ono Y, Nakanishi N, Yamada I, Kotani J
    Aug. 2022, Oxf Med Case Reports., 2022(8) (8), omac083 - omac083, English, No password, International magazine
    [Refereed]

  • Takaki Hirano, Yudai Iwasaki, Yuko Ono, Tokiya Ishida, Kazuaki Shinohara
    Elsevier BV, Jul. 2022, Annals of Vascular Surgery, - S0890-5096(22)00328-4, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Shingen Misaka, Yuko Ono, R. Verena Taudte, Eva Hoier, Hiroshi Ogata, Tomoyuki Ono, Jörg König, Hiroshi Watanabe, Martin F. Fromm, Kenju Shimomura
    Wiley, Jun. 2022, Clinical Pharmacology & Therapeutics, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Nobuto Nakanishi, Yuko Ono, Isamu Yamada, Joji Kotani
    Wiley, Jun. 2022, Journal of the American College of Emergency Physicians Open, 3(3) (3), English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Yudai Iwasaki, Takaki Hirano, Katsuhiko Hashimoto, Takeyasu Kakamu, Shigeaki Inoue, Joji Kotani, Kazuaki Shinohara
    Injured patients requiring definitive intervention, such as surgery or transarterial embolization (TAE), are an extremely time-sensitive population. The effect of an emergency physician (EP) patient care delivery system in this important trauma subset remains unclear. We aimed to clarify whether the preoperative time course and mortality among injured patients differ between ambulances staffed by EPs and those staffed by emergency life-saving technicians (ELST). This was a retrospective cohort study at a community emergency department (ED) in Japan. We included all injured patients requiring emergency surgery or TAE who were transported directly from the ED to the operating room from January 2002 to December 2019. The primary exposure was dispatch of an EP-staffed ambulance to the prehospital scene. The primary outcome measures were preoperative time course including prehospital length of stay (LOS), ED LOS, and total time to definitive intervention. The other outcome of interest was in-hospital mortality. One-to-one propensity score matching was performed to compare these outcomes between the groups. Of the 1,020 eligible patients, 353 (34.6%) were transported to the ED by an EP-staffed ambulance. In the propensity score-matched analysis with 295 pairs, the EP group showed a significant increase in median prehospital LOS (71.0 min vs. 41.0 min, P < 0.001) and total time to definitive intervention (189.0 min vs. 177.0 min, P = 0.002) in comparison with the ELST group. Conversely, ED LOS was significantly shorter in the EP group than in the ELST group (120.0 min vs. 131.0 min, P = 0.043). There was no significant difference in mortality between the two groups (8.8% vs.9.8%, P = 0.671). At a community hospital in Japan, EP-staffed ambulances were found to be associated with prolonged prehospital time, delay in definitive treatment, and did not improve survival among injured patients needing definitive hemostatic procedures compared with ELST-staffed ambulances.
    Public Library of Science (PLoS), Nov. 2021, PLOS ONE, 16(11) (11), e0259733 - e0259733, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuta Arai, Nobuto Nakanishi, Yuko Ono, Shigeaki Inoue, Joji Kotani, Masafumi Harada, Jun Oto
    Elsevier BV, Oct. 2021, Clinical Nutrition ESPEN, 45, 177 - 183, No password, International magazine
    [Refereed]
    Scientific journal

  • Joji Kotani, Hiroyuki Nakao, Isamu Yamada, Atsushi Miyawaki, Naomi Mambo, Yuko Ono
    Background: Physicians currently measure the pupil diameter and the pupillary light reflex with visual observations using a ruler and a traditional penlight, leading to possibly inaccurate and subjective assessments. Although a mobile pupillometer has been developed and is available in clinical settings, this device can only assess one pupil at a time. Hence, an indirect pupillary light reflex, including those under irradiation to the opposite side of pupil, cannot be evaluated. Consequently, we have developed a new automatic mobile pupilometer, the Hitomiru®, with Hitomiru Co., Ltd. (Tokyo, Japan). This device is a two-glass type pupilometer with a video recording system. The pupil diameter and light reflex of both pupils can be measured simultaneously; therefore, both indirect and direct light reflexes can be assessed. Purpose: To evaluate the clinical ability of the Hitomiru® pupilometer to assess the pupil diameter and the pupillary light reflex of healthy volunteers and patients with intracranial lesions in an intensive care unit (ICU). Methods: Twenty-five healthy volunteers and five ICU patients with intracranial lesions on only the left side were assessed using the Hitomiru® pupilometer. The protocol was as follows: infrared light was applied to both pupils, followed by visible light to the right pupil, infrared light to both pupils, visible light to the left pupil, and then infrared light to both pupils. All the intervals were 2 s, and the dynamics of pupil diameters on both sides were continuously recorded. Results: The healthy adults had approximately 0.5 mm anisocoria, miosis was harder, and mydriasis was less with increased age. There were several differences in miosis rates, miosis times, and mydriasis rates between the healthy adults and the patients with intracranial lesions with both direct irradiation and indirect irradiation. Conclusions: The initial trial estimated and digitally recorded direct and indirect light reflexes, including rapidity of miosis after direct and indirect lights on, and mydriasis after direct and indirect lights off. The Hitomiru® pupilometer was a useful device to digitally record and investigate the relationship between pupil reflexes and intracranial diseases.
    Last, Frontiers Media SA, Sep. 2021, Frontiers in Medicine, 8, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Nobuto Nakanishi, Shigeaki Inoue, Rie Tsutsumi, Yusuke Akimoto, Yuko Ono, Joji Kotani, Hiroshi Sakaue, Jun Oto
    MDPI AG, Jun. 2021, Journal of Clinical Medicine, 10(12) (12), 2721 - 2721, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Nozomi Ono, Takeyasu Kakamu, Tokiya Ishida, Shigeaki Inoue, Joji Kotani, Kazuaki Shinohara
    Ovid Technologies (Wolters Kluwer Health), Jun. 2021, Medicine, 100(22) (22), e26252 - e26252, English, No password
    [Refereed]
    Scientific journal

  • Yoshihisa Fujinami, Toru Hifumi, Yuko Ono, Masafumi Saito, Tomoya Okazaki, Natsuyo Shinohara, Kyoko Akiyama, Misa Kunikata, Shigeaki Inoue, Joji Kotani, Yasuhiro Kuroda
    A single-center retrospective cohort study examined the association between molar malocclusion status at ICU admission and loss of activities of daily living (ADL) at hospital discharge among acutely ill patients. Patients were assigned to the bilateral occlusion group or malocclusion group (N = 227 and 93, respectively). The following data were collected from electronic medical records: age, sex, Clinical Frailty Scale (CFS) on admission, Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score, confirmed diagnosis (neurological disorders or others), CFS at hospital discharge, and occlusion condition. Patients who were frail at admission (CFS > 5) were excluded from analysis, and ADL loss was defined as CFS > 5 at hospital discharge. Multivariate analysis showed malocclusion was independently associated with ADL loss [OR, 2.03; 95% CI, 1.13–3.64; p = 0.02]. For those aged 65 and older, malocclusion was significantly associated with both ADL loss [OR, 3.25; 95% CI, 1.44–7.32; p < 0.01] and the incidence of delirium [OR, 2.61; 95% CI, 1.14–5.95; p = 0.02]. Malocclusion on ICU admission was associated with ADL loss in critically ill patients, and was associated with ADL loss and the incidence of delirium in the elderly. Poor oral health was a poor prognostic factor among critically ill patients.
    MDPI AG, May 2021, Journal of Clinical Medicine, 10(10) (10), 2157 - 2157, English, No password
    [Refereed]
    Scientific journal

  • Yoshihisa Fujinami, Shigeaki Inoue, Yuko Ono, Yusuke Miyazaki, Kazumichi Fujioka, Kimihiro Yamashita, Joji Kotani
    Post-intensive care syndrome (PICS) is a physical, cognitive, and mental impairment observed in intensive care unit (ICU) survivors. Although this is an emerging problem in the ICU, how sepsis induces the characteristic symptoms of PICS remains unclear. To develop a model of PICS, we induced sepsis in male C57/B6 mice via sublethal cecum slurry injection and subsequently treated them using ICU-like interventions. At 1–2 weeks post-sepsis induction, we simultaneously evaluated the abilities of the surviving mice using the following behavioral tests: (1) a grip strength test (GST) and a treadmill test for physical assessment, (2) a novel object recognition test (NORT) for cognitive assessment, and (3) an open field test (OFT) and a marble burying test (MBT) for mental assessment. The surviving mice showed a range of deficits, including muscle weakness with significantly decreased grip strength in the GST; decreased total mileage during the treadmill test; anxiety and decreased activity, with significantly decreased time in the central area, and increased duration of immobility in the OFT; and an increased number of buried marbles in the MBT. Given these physical and mental impairments in the surviving mice, our model has the potential to elucidate mechanistic insights and to discover therapeutic targets and new interventions for PICS.
    MDPI AG, Apr. 2021, Journal of Clinical Medicine, 10(8) (8), 1593 - 1593, English, No password
    [Refereed]
    Scientific journal

  • Shoichiro Horita, Tomoyuki Ono, Saul Gonzalez-Resines, Yuko Ono, Megumi Yamachi, Songji Zhao, Carmen Domene, Yuko Maejima, Kenju Shimomura
    AbstractDevelopmental delay, epilepsy, and neonatal diabetes (DEND) syndrome, the most severe end of neonatal diabetes mellitus, is caused by mutation in the ATP-sensitive potassium (KATP) channel. In addition to diabetes, DEND patients present muscle weakness as one of the symptoms, and although the muscle weakness is considered to originate in the brain, the pathological effects of mutated KATP channels in skeletal muscle remain elusive. Here, we describe the local effects of the KATP channel on muscle by expressing the mutation present in the KATP channels of the DEND syndrome in the murine skeletal muscle cell line C2C12 in combination with computer simulation. The present study revealed that the DEND mutation can lead to a hyperpolarized state of the muscle cell membrane, and molecular dynamics simulations based on a recently reported high-resolution structure provide an explanation as to why the mutation reduces ATP sensitivity and reveal the changes in the local interactions between ATP molecules and the channel.
    Springer Science and Business Media LLC, Mar. 2021, Scientific Reports, 11(1) (1), 6668 - 6668, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuko Ono, Masafumi Saito, Chiaki Shinohara, Kazuaki Shinohara, Shigeaki Inoue, Joji Kotani
    Background: Publication in a scientific journal is the desired outcome of the research cycle. However, previous anesthesiology research has not thoroughly examined factors predictive of subsequent publication after a meeting presentation. We aimed to assess the rate of peer-reviewed publication of abstracts presented at the Japanese Society of Anesthesiologists (JSA) annual meetings and identify factors associated with successful publication. Methods: This study included all abstracts presented at JSA meetings from 2015 to 2017. The outcome of interest was subsequent publication of abstracts in journals included in the MEDLINE database within 36 months after presentation. Differences between published and non-published abstracts were evaluated. Results: Among the 2,418 eligible abstracts, 487 were published within 3 years (publication rate, 20.1%). Multivariable logistic regression analysis showed that factors independently associated with subsequent publication were: presentation style (poster discussions: adjusted odds ratios (AOR) 1.70, 95% confidence interval [CI] 1.31-2.20; excellent abstracts: AOR 2.82, 95% CI 1.98-4.01); basic research (AOR 4.39, 95%CI 3.23-5.96), male first author (AOR 1.41, 95% CI 1.09-1.81); region (Kansai: AOR 2.16, 95% CI 1.57-2.99; abroad: AOR 4.57, 95% CI 2.58-8.09); facility characteristics (private university: AOR 3.97, 95% CI 2.60-6.08; public university: AOR 3.53, 95%CI 2.35-5.30; medical company: AOR 16.70, 95% CI 3.75-74.46); and number of collaborating facilities (two: AOR 1.50, 95% CI 1.15-1.97; three: AOR 1.83, 95% CI 1.23-2.73; four: AOR 2.40, 95% CI 1.27-4.54). Conclusions: Approximately one-fifth of abstracts presented at JSA meetings are published in peer-reviewed journals within 3 years. Factors independently associated with subsequent full publication are presentation style, basic research, male gender, specific region, affiliation characteristics, and number of collaborating facilities. Our data should stimulate further studies that elucidate ways to assist the full publication process of meeting abstracts.
    MRE Press, Mar. 2021, Signa Vitae, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Yuzo Iseki, Yuko Ono, Chihiro Hibi, Shoko Tanaka, Shunya Takeshita, Yuko Maejima, Junko Kurokawa, Masahiro Murakawa, Kenju Shimomura, Kazuho Sakamoto
    American Society for Pharmacology & Experimental Therapeutics (ASPET), Dec. 2020, Journal of Pharmacology and Experimental Therapeutics, 376(3) (3), 454 - 462, English, No password
    [Refereed]
    Scientific journal

  • Yudai Iwasaki, Yuko Ono, Ryota Inokuchi, Tokiya Ishida, Yoshibumi Kumada, Kazuaki Shinohara
    Ovid Technologies (Wolters Kluwer Health), Dec. 2020, Medicine, 99(50) (50), e23617 - e23617, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Masafumi Saito, Yoshihisa Fujinami, Yuko Ono, Shohei Ohyama, Kazumichi Fujioka, Kimihiro Yamashita, Shigeaki Inoue, Joji Kotani
    Sepsis-associated encephalopathy (SAE) increases not only morbidity and mortality but has been associated with long-lasting mental impairment after hospital discharge in septic patients. Recently, studies have shown that these mental impairments are caused by infection-induced neuroinflammation. However, the role of T cells in the pathogenesis of SAE and mental impairments remains unclear. Thus, in this study, we aimed to clarify how immune cells, especially T cells, influence the development and recovery of these disorders. In the cecal slurry (CS)-induced septic mouse model, we performed three different kinds of behavioral tests, open-field test, marble burying test, and forced swimming test, and observed anxiety-like behavior in septic mice. Additionally, increased interleukin (IL)-1β and IL-6 expression levels, and infiltration of neutrophils and T cells were examined in the brain of septic mice, 10 days after sepsis onset. Twenty days after sepsis onset, the septic mice could recover the number of astrocytes. At day 30, expression levels of IL-1β and tumor necrosis factor (TNF)-α returned to normal levels in the cerebral cortex of septic mice. Interestingly, resolution of neuroinflammation and alleviation of depression were delayed in septic mice treated with FTY720, which inhibits sphingosine-1-phosphate (S1P)-dependent lymphocyte egress from lymph nodes. On analyzing the brain T cells with or without FTY720 in septic mice, the FTY720 untreated mice presented increased regulatory T cells (Treg) and Th2 cells in the brain, whereas the FTY720 treated mice demonstrated increased Th17 in the brain at day 30. Furthermore, in FTY720 treated septic mice, the number of astrocytes in the cerebral cortex remained reduced at day 30. These results suggest that infiltrated Treg and Th2 cells contribute to the attenuation SAE and alleviate SAE-induce mental disorder by resolving neuroinflammation in the chronic phase of sepsis.
    Elsevier BV, Nov. 2020, Brain, Behavior, and Immunity, 92, 25 - 38, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Shingen Misaka, Yuko Ono, Atsushi Uchida, Tomoyuki Ono, Osamu Abe, Hiroshi Ogata, Hideyuki Sato, Masahiko Suzuki, Satomi Onoue, Yayoi Shikama, Kenju Shimomura
    Wiley, Oct. 2020, Clinical and Translational Science, 14(2) (2), 476 - 480, English, No password
    [Refereed]
    Scientific journal

  • The Pathophysiology of Sepsis-Induced ICU-Acquired Weakness (in Japanese)
    Ono Y, Saito M, Fujinami Y, Inoue S, Kotani J
    Igakutosho-shuppan Ltd., Tokyo, Japan, Oct. 2020, Japanese Journal of Intensive Care Medicine, 44(5) (5), 251 - 258, Japanese, No password, Domestic magazine
    [Refereed][Invited]

  • Ono Y, Saito M, Fujinami Y, Inoue S, Kotani J
    Sep. 2020, The Japanese Journal of Surgical Metabolism and Nutrition, 54(3) (3), 139 - 142, Japanese, No password
    [Refereed][Invited]

  • Ono Y, Shinohara K, Shimada J, Inoue S, Kotani J
    BMC Emerg Med, May 2020, BMC Emerg Med. 2020;20(1):34., 20(1) (1), 34, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Imai R, Horita S, Ono Y, Hagihara K, Shimizu M, Maejima Y, Shimomura K
    Goshajinkigan (GJG) is a traditional Japanese Kampo medicine used clinically to treat muscle pain in Japan. However, its underlying mechanism remains unclear. Since voltage-gated sodium channel (Nav) 1.4 is involved in skeletal muscle contraction, we investigated the possibility that GJG may affect Nav1.4 currents. By using an electrophysiological technique on skeletal muscle cell line C2C12, we found that GJG suppresses Nav1.4 currents in C2C12 cells. It is suggested that GJG may improve skeletal muscle stiffness or cramps by inhibiting abnormal Nav1.4 excitation. GJG may act as a Nav1.4 blocker and may be useful to treat muscle stiffness and clamps as well as easing the pain.
    Apr. 2020, Biores Open Access. 2020;9:116–120., 9(1) (1), 116 - 120, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Misaka S, Abe O, Ono T, Ono Y, Ogata H, Miura I, Shikama Y, Fromm MF, Yabe H, Shimomura K
    AIMS: The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. METHODS: In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed GT, or with water in a volume of 150 mL. RESULTS: Geometric mean ratio with 90% confidence interval for nadolol AUC0-48 was 0.371 (0.303-0.439) with concomitant GT. In addition, ingestion of GT 1 hour before nadolol administration resulted in a significant reduction of nadolol AUC0-48 with geometric mean ratio of 0.536 (0.406-0.665). There were no differences in time to maximal plasma concentration and renal clearance of nadolol among groups. CONCLUSION: These results suggest that single concomitant ingestion of GT substantially decreases plasma concentrations of nadolol. Moreover, the reduction in nadolol bioavailability could persist for at least 1 hour after drinking a cup of GT.
    Apr. 2020, Br J Clin Pharmacol. 2020 Apr 22., 2020, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Ono Y, Goto A, Maejima Y, Maruyama I, Suzuki T, Shikama Y, Yoshida-Komiya H.
    Objectives: To clarify (1) the prevalence and associating factors of work-life conflict (WLC);(2) the details of gender-based discrimination;and (3) the association between WLC and gender-based discrimination among various professionals in a medical university organization. Methods: This cross-sectional study, conducted in 2017, included all employees working at a public medical university and two affiliated hospitals that lie in provincial cities in Japan. The outcome of interest was time-based WLC in the work-to-family or family-to-work direction, measured with a shortened version of an existing scale. Gender-based discrimination was measured according to a three-point scale. Results: Among the 3,347 employees, complete data sets were available for 2,285 (complete response rate, 68.3%). Of these, approximately 30% of respondents had perceived WLC. Multivariable logistic regression analysis showed that faculty members, nurses, and employees between 30 and 39 years old had a greater risk of WLC regardless of gender. Men were more likely to perceive gender-based discrimination in the contents of their work and the number of incidental tasks, while women were more likely to perceive discrimination with promotions and evaluation of academic achievements. Both men and women respondents who perceived gender-based discrimination had an increased risk of WLC. Conclusions: When promoting organizational well-being in a medical university, increased attention should be paid to faculty members, nurses and employees between 30 and 39 years old, as they have a greater risk of WLC. Our results also suggest that promoting gender equality is important to help achieve appropriate work-life balance.
    Fukushima J Med Sci., Apr. 2020, Fukushima J Med Sci., 66(1) (1), 25 - 36, English, No password
    [Refereed]
    Scientific journal

  • Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J
    Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or various endogenous diseases related to bacterial translocation from the gut. Systemic inflammatory responses induced by endotoxemia induce severe involuntary loss of skeletal muscle, termed muscle wasting, which adversely affects the survival and functional outcomes of these patients. Currently, no drugs are available for the treatment of endotoxemia-induced skeletal muscle wasting. Here, we tested the effects of TAK-242, a Toll-like receptor 4 (TLR4)-specific signalling inhibitor, on myotube atrophy in vitro and muscle wasting in vivo induced by endotoxin. LPS treatment of murine C2C12 myotubes induced an inflammatory response (increased nuclear factor-κB activity and interleukin-6 and tumour necrosis factor-α expression) and activated the ubiquitin-proteasome and autophagy proteolytic pathways (increased atrogin-1/MAFbx, MuRF1, and LC-II expression), resulting in myotube atrophy. In mice, LPS injection increased the same inflammatory and proteolytic pathways in skeletal muscle and induced atrophy, resulting in reduced grip strength. Notably, pretreatment of cells or mice with TAK-242 reduced or reversed all the detrimental effects of LPS in vitro and in vivo. Collectively, our results indicate that pharmacological inhibition of TLR4 signalling may be a novel therapeutic intervention for endotoxemia-induced muscle wasting.
    nature publishing group, Jan. 2020, Scientific reports, 10(1) (1), 694 - 694, English, No password, International magazine
    [Refereed]
    Scientific journal

  • Masafumi Saito, Shigeaki Inoue, Yoshihisa Fujinami, Yuko Ono, Shohei Ohyama, Joji Kotani
    2020, Endotoxin and Innate Immunity, 23, 12 - 15, Japanese, No password, Domestic magazine
    [Refereed]
    Scientific journal

  • Ono Y, Kakamu T, Ishida T, Sasaki T, Inoue S, Kotani J, Shinohara K
    BACKGROUND:
    Commencement of a new academic cycle is presumed to be associated with poor patient outcomes. However, supportive evidence is limited for trauma patients treated in under-resourced hospitals, especially those who require specialized interventions and with little physiological reserve. We examined whether a new academic cycle affects the survival outcomes of injured patients in a typical Japanese teaching hospital.

    METHODS:
    This historical cohort study was conducted at a Japanese community emergency department (ED). All injured patients brought to the ED from April 2002 to March 2018 were included in the analysis. The primary exposure was presentation to the ED during the first quartile of the academic cycle (April-June). The primary outcome measure was the hospital mortality rate.

    RESULTS:
    Of the 20,945 eligible patients, 5282 (25.2%) were admitted during the first quartile. In the univariable analysis, the hospital mortality rate was similar between patients admitted during the first quartile of the academic year and those admitted during the remaining quartiles (4.1% vs. 4.4%, respectively; odds ratio [OR], 0.931; 95% confidence interval [CI] 0.796-1.088). After adjusting for the potential confounding factors of the injury severity score, age, sex, Glasgow coma scale score, systolic blood pressure, trauma etiology (blunt or penetrating), and admission phase (2002-2005, 2006-2009, 2010-2013, and 2014-2018), no statistically significant association was present between first-quartile admission and trauma death (adjusted OR 0.980; 95% CI 0.748-1.284). Likewise, when patients were subgrouped according to age of > 55 years, injury severity score of > 15, Glasgow coma scale score of < 9, systolic blood pressure of < 90 mmHg, requirement for doctor car system dispatches, emergency operation, emergency endotracheal intubation, and weekend and night presentation, no significant associations were present between first-quartile admission and hospital mortality in both the univariable and multivariable analysis.

    CONCLUSIONS:
    At a community hospital in Japan, admission at the beginning of the academic year was not associated with an increased risk of hospital mortality among trauma patients, even those requiring specialized interventions and with little physiological reserve. Our results support the uniformity of trauma care provision throughout the academic cycle in a typical Japanese trauma system.
    Aug. 2019, J Intensive Care, 7(39) (39), English, No password
    [Refereed]
    Scientific journal

  • Brzeziński P, Martini L, Di Martino OB, Sajjan V, Narita M, Ono Y, Parajuli R, Dey B, Krüger GM, Bourée P
    Apr. 2019, Our Dermatol Online., 10(2) (2), 224 - 228, English
    [Refereed]
    Scientific journal


  • Ono Y, Kakamu T, Kikuchi H, Mori Y, Watanabe Y, Shinohara K
    Jun. 2018, Emerg Med Int. 2018;2018:5649476., English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Jiro Shimada, Kazuaki Shinohara
    Springer Tokyo, Oct. 2017, Journal of Anesthesia, 31(5) (5), 797, English, No password
    [Refereed][Invited]
    Scientific journal

  • Ono Y, Shinohara K, Tanigawa K
    Difficult airways and severe airway-related adverse events occur much more commonly in emergency departments and ICUs than in operating rooms. Thus, rescue ventilation strategies are indispensable in emergency departments and ICUs. Rescue ventilation techniques in time-sensitive situations must be fast, simple and easy to perform. Considering this situation, supraglottic airway devices are near-ideal instruments. Using a supraglottic airway device is a common first-line rescue ventilation strategy in difficult airway management (DAM) algorithms advocated by several professional anesthesiology societies. Furthermore, supraglottic airway devices are also proving to be useful for DAM in emergency departments and ICUs, and evidence supporting their implementation in such environments is increasing. However, supraglottic airway devices are much less likely to be available in Japanese emergency medical services and ICUs than in other countries. Immediate access to appropriate DAM devices, including supraglottic airways, is essential to ensure safety. The aim of this study was to reappraise the role of supraglottic airway devices in the field of emergency and critical care medicine.
    The Japanese Society of Intensive Care Medicine, Sep. 2017, J Jpn Soc Intensive Care Med, 24(5) (5), 535 - 541, Japanese, No password
    [Refereed][Invited]
    Scientific journal

  • Ono Y, Tanigawa K, Shinohara K, Yano T, Sorimachi K, Inokuchi R, Shimada J
    Background: Although human and equipment resources, proper training, and the verification of endotracheal intubation are vital elements of difficult airway management (DAM), their availability in Japanese emergency departments (EDs) has not been determined. How ED type and patient volume affect DAM preparation is also unclear. We conducted the present survey to address this knowledge gaps. Methods: This nationwide cross-sectional study was conducted from April to September 2016. All EDs received a mailed questionnaire regarding their DAM resources, airway training methods, and capnometry use for tube placement. Outcome measures were the availability of: (1) 24-h in-house back-up; (2) key DAM resources, including a supraglottic airway device (SGA), a dedicated DAM cart, surgical airway devices, and neuromuscular blocking agents; (3) anesthesiology rotation as part of an airway training program; and (4) the routine use of capnometry to verify tube placement. EDs were classified as academic, tertiary, high-volume (upper quartile of annual ambulance visits), and urban. Results: Of the 530 EDs, 324 (61.1%) returned completed questionnaires. The availability of in-house back-up coverage, surgical airway devices, and neuromuscular blocking agents was 69.4, 95.7, and 68.5%, respectively. SGAs and dedicated DAM carts were present in 51.5 and 49.7% of the EDs. The rates of routine capnometry use (47.8%) and the availability of an anesthesiology rotation (38.6%) were low. The availability of 24-h back-up coverage was significantly higher in academic EDs and tertiary EDs in both the crude and adjusted analysis. Similarly, neuromuscular blocking agents were more likely to be present in academic EDs, high-volume EDs, and tertiary EDs; and the rate of routine use of capnometry was significantly higher in tertiary EDs in both the crude and adjusted analysis. Conclusions: In Japanese EDs, the rates of both the availability of SGAs and DAM carts and the use of routine capnometry to confirm tube placement were approximately 50%. These data demonstrate the lack of standard operating procedures for rescue ventilation and post-intubation care. Academic, tertiary, and high-volume EDs were likely to be well prepared for DAM.
    Springer open, Sep. 2017, Int J Emerg Med., 13(10) (10), 28 - 28, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Kazuho Sakamoto
    Lead, Public Library of Science, Jul. 2017, PLoS ONE, 12(7) (7), e0182040, English, No password
    [Refereed][Invited]
    Scientific journal

  • Ono Y, Ono N, Shinohara K
    Naphazoline is a peripheral ����2-adrenergic receptor agonist commonly used as a topical decongestant. In Japan, over-thecounter antiseptics often contain naphazoline to effect local hemostasis. We present the first case involving the development of hypercoagulopathy, with kidney and liver dysfunction, following a naphazoline overdose. A 22-year-old Japanese woman with a history of depression ingested 160mL of a commercially available antiseptic containing 0.1% naphazoline. Three days later, she was brought to the emergency department because of general fatigue, nausea, and vomiting. Physical examination revealed cool, pale extremities. Laboratory data showed evidence of severe kidney and liver dysfunction (creatinine, 9.2mg/dL; alanine aminotransferase, 2948 IU/L), hypercoagulation (D-dimers, 58.3 ����g/mL), and thrombocytopenia (platelet count, 90,000/����L). After infusion of normal saline, intravenous administration of alprostadil, and hemodiafiltration, her organ function completely recovered. Because both the kidney and liver express ����2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion. The most plausible causes of hypercoagulation are peripheral low perfusion and subsequent microthrombus formation. This case illustrates that severe organ dysfunction can occur following over-the-counter antiseptic ingestion and serves as a caution for both drug manufacturers and healthcare professionals.
    Hindawi, May 2017, Case Rep Emerg Med., 2017, 2017;2017:3968045. - 3968045, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Miha Kunii, Tomohiro Miura, Kazuaki Shinohara
    BioMed Central Ltd., May 2017, Journal of Medical Case Reports, 11(1) (1), 121, English, No password
    [Refereed]
    Scientific journal

  • Shoko Tanaka, Yuko Ono, Kazuho Sakamoto
    Japanese Pharmacological Society, Apr. 2017, Journal of Pharmacological Sciences, 133(4) (4), 276 - 279, English
    [Refereed]
    Scientific journal

  • Yuko Ono, Takuya Sugiyama, Yasuyuki Chida, Tetsuya Sato, Hiroaki Kikuchi, Daiji Suzuki, Masakazu Ikeda, Koichi Tanigawa, Kazuaki Shinohara
    BioMed Central Ltd., Aug. 2016, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 24(1) (1), English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Koichi Tanigawa, Kazuaki Shinohara, Tetsuhiro Yano, Kotaro Sorimachi, Lubna Sato, Ryota Inokuchi, Jiro Shimada, Choichiro Tase
    Springer Tokyo, Aug. 2016, Journal of Anesthesia, 30(4) (4), 644 - 652, English, No password
    [Refereed]
    Scientific journal

  • Kotaro Sorimachi, Yuko Ono, Hideo Kobayashi, Kazuyuki Watanabe, Kazuaki Shinohara, Koji Otani
    Corresponding, BioMed Central Ltd., Jun. 2016, Journal of Medical Case Reports, 10(1) (1), 172, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Kazuaki Shinohara, Aya Goto, Tetsuhiro Yano, Lubna Sato, Hiroyuki Miyazaki, Jiro Shimada, Choichiro Tase
    Apr. 2016, J Anesth., 30(2) (2), 205 - 214, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Hiroaki Kikuchi, Katsuhiko Hashimoto, Tetsu Sasaki, Jyunya Ishii, Choichiro Tase, Kazuaki Shinohara
    Springer Tokyo, Oct. 2015, Journal of Anesthesia, 29(5) (5), 678 - 685, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Yoshinori Okubo, Katsuhiko Hashimoto, Ryota Inokuchi, Hajime Odajima, Choichiro Tase, Kazuaki Shinohara
    Springer-Verlag Tokyo, Aug. 2015, Journal of Anesthesia, 29(4) (4), 622 - 626, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Yoshinobu Abe, Kazuaki Shinohara
    Springer-Verlag Tokyo, Apr. 2015, Journal of Anesthesia, 29(2) (2), 320, English, No password
    [Refereed]
    Scientific journal

  • Hamaya R, Ono Y, Chida Y, Inokuchi R, Kikuchi K, Tameda T, Tase C, Shinohara K
    INTRODUCTION: Polytetrafluoroethylene is ubiquitous in materials commonly used in cooking and industrial applications. Overheated polytetrafluoroethylene can generate toxic fumes, inducing acute pulmonary edema in some cases. However, neither the etiology nor the radiological features of this condition have been determined. For clarification, we report an illustrative case, together with the first comprehensive literature review. CASE PRESENTATION: A previously healthy 35-year-old Japanese man who developed severe dyspnea presented to our hospital. He had left a polytetrafluoroethylene-coated pan on a gas-burning stove for 10 hours while unconscious. Upon admission, he was in severe respiratory distress. A chest computed tomographic scan showed massive bilateral patchy consolidations with ground-glass opacities and peripheral area sparing. A diagnosis of polytetrafluoroethylene fume-induced pulmonary edema was made. He was treated with non-invasive positive pressure ventilation and a neutrophil elastase inhibitor, which dramatically alleviated his symptoms and improved his oxygenation. He was discharged without sequelae on hospital day 11. A literature review was performed to survey all reported cases of polytetrafluoroethylene fume-induced pulmonary edema. We searched the PubMed, Embase, Web of Science and OvidSP databases for reports posted between the inception of the databases and 30 September 2014, as well as several Japanese databases (Ichushi Web, J-STAGE, Medical Online, and CiNii). Two radiologists independently interpreted all chest computed tomographic images. Eighteen relevant cases (including the presently reported case) were found. Our search revealed that (1) systemic inflammatory response syndrome was frequently accompanied by pulmonary edema, and (2) common computed tomography findings were bilateral ground-glass opacities, patchy consolidation and peripheral area sparing. Pathophysiological and radiological features were consistent with the exudative phase of acute respiratory distress syndrome. However, the contrast between the lesion and the spared peripheral area was striking and was distinguishable from the common radiological features of acute respiratory distress syndrome. CONCLUSION: The essential etiology of polytetrafluoroethylene fume-induced pulmonary edema seems to be increased pulmonary vascular permeability caused by an inflammatory response to the toxic fumes. The radiological findings that distinguish polytetrafluoroethylene fume-induced pulmonary edema can be bilateral ground-glass opacity or a patchy consolidation with clear sparing of the peripheral area.
    Corresponding, BioMed Central, Mar. 2015, J Med Case Rep., 9(111) (111), 111 - 111, English, No password
    [Refereed]
    Scientific journal

  • Ono Y, Ishida T, Iwasaki Y, Kawakami Y, Inokuchi R, Tase C, Shinohara K
    Background: Because most community hospitals in Japan do not maintain 24-h availability of in-house anesthesiologists, surgeons, and interventional radiologists, staffing dramatically declines during off hours. It is unclear whether, in such under-resourced hospitals, trauma patients presenting during off hours and requiring subspecialty intervention have worse outcomes than those who present during business hours. Methods: This was a retrospective cohort study at a community hospital in Japan. Participants were all injured patients requiring emergency trauma surgery or transarterial embolization who presented from January 2002 to December 2013. We investigated whether outcomes of these patients differed between business hours (8:01 AM to 6:00 PM weekdays) and off hours (6:01 PM to 8:00 AM weekdays plus all weekend hours). The primary outcome measure was mortality rate, and the secondary outcome measures were duration of emergency room (ER) stay; unexpected death (death/probability of survival > 0.5); and adverse events occurring in the ER. We adjusted for potential confounders of age, sex, Injury Severity Score (ISS), Revised Trauma Score, presentation phase (2002–2005, 2006–2009, and 2010–2013), Charlson Comorbidity Index, and injury type (blunt or penetrating) using logistic regression models. Results: Of the 805 patients included, 379 (47.1%) presented during business hours and 426 (52.9%) during off hours. Off-hours presentation was associated with longer ER stays for patients with systolic blood pressure < 90 mmHg on admission (p = 0.021), ISS >15 (p = 0.047), and pelvic fracture requiring transarterial embolization (p < 0.001). Off-hours presentation was also associated with increased risk of adverse events in the ER (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.1–2.7, p = 0.020). After adjustment for confounders, an increased risk of adverse events (OR 1.6, 95% CI 1.1–2.7, p = 0.049) persisted, but no differences were detected in mortality (p = 0.80) and unexpected death (p = 0.44) between off hours and business hours. Conclusions: At a community hospital in Japan, presentation during off hours was associated with a longer ER stay for severely injured patients and increased risk of adverse events in the ER. However, these disadvantages did not impact mortality or unexpected outcome.
    BioMed Central, Feb. 2015, Scand J Trauma Resusc Emerg Med., 23(20) (20), 20 - 20, English, No password
    [Refereed]
    Scientific journal

  • Piotr Brzeziński, David F. Fiorentino, Pavai Arunachalam, Ioannis Katafigiotis, Łukasz Matuszewski, Masashi Narita, Yuko Ono, Rahul Shetty, Anca Chiriac, Ahmad Abdulaziz
    2014, Our Dermatol Online., 5(1) (1), 95-102., English
    [Refereed]
    Scientific journal

  • Yuko Ono, Hideyuki Yokoyama, Akinori Matsumoto, Yoshibumi Kumada, Kazuaki Shinohara, Choichiro Tase
    Springer-Verlag Tokyo, 2014, Journal of Anesthesia, 28(3) (3), 381 - 389, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Hideyuki Yokoyama, Akinori Matsumoto, Yoshibumi Kumada, Kazuaki Shinohara, Choichiro Tase
    Springer, Dec. 2013, Journal of Anesthesia, 27(6) (6), 832 - 837, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Mariko Satou, Yukihiro Ikegami, Jiro Shimada, Arifumi Hasegawa, Yasuhiko Tsukada, Chiaki Nemoto, Kazuaki Shinohara, Choichiro Tase
    Elsevier, Nov. 2013, Air Medical Journal, 32(6) (6), 346 - 349, English, No password
    [Refereed]
    Scientific journal

  • Megumi Okada, Ryota Inokuchi, Kazuaki Shinohara, Akinori Matsumoto, Yuko Ono, Masashi Narita, Tokiya Ishida, Chiba Kazuki, Susumu Nakajima, Naoki Yahagi
    BioMed Central, Sep. 2013, BMC Infectious Diseases, 13(1) (1), 406, English
    [Refereed]
    Scientific journal

  • Yoshinobu Abe, Yukihiro Ikegami, Jiro Shimada, Yasuhiko Tsukada, Arifumi Hasegawa, Chiaki Nemoto, Yuko Ono, Choichiro Tase
    The Japanese Society of Intensive Care Medicine, Jul. 2013, J Jpn Soc Intensive Care Med, 20(3) (3), 425 - 426, Japanese, No password
    Scientific journal

  • Shinohara K, Hashimoto K, Saito I, Ono Y, Fumihito I, Megumi O, Tokiya I, Hideyuki Y, Yoshibumi K, Akinori M
    過去16.5年間に交通事故で当院に救急搬送された四輪車乗員5369例を対象に,シートベルトがどのような外力に対して有効なのかを調査した.患者に加わった主な外力が正面からの場合はもちろん,患者側/患者と反対側の側面からの場合,後面からの場合も,シートベルト着用群では非着用群に比べ重症外傷が有意に少なかった.
    自動車技術会, 2013, Transactions of Society of Automotive Engineers of Japan, 44(5) (5), 1263 - 1267, Japanese, No password, Domestic magazine
    [Refereed]

  • Ono Y, Ikegami Y, Shimada J, Hasegawa A, Tsukada Y, Shinohara K, Tase C
    日本救急医学会, 2013, 日本救急医学会雑誌, 24, 12 - 18, English, No password
    [Refereed]
    Scientific journal

  • Yuko Ono, Yukihiro Ikegami, Kazuhiro Tasaki, Masahumi Abe, Choichiro Tase
    Elsevier, Oct. 2012, EMA - Emergency Medicine Australasia, 24(5) (5), 577 - 580, English, No password, International magazine
    [Refereed]
    Scientific journal

  • CHOICHIRO TASE, YUKO OHNO, ARIFUMI HASEGAWA, YASUHIKO TUKADA, JIRO SHIMADA, YUKIHIRO IKEGAMI, NOBUO SAKAMOTO, YASUCHIKA TAKEISHI
    In the case of acute myocardial infarction (AMI), prompt and appropriate initial treatment is essential for increasing the rate of survival and early reperfusion is a main determinant factor for long-term prognosis. The survival of a patient with refractory ventricular fibrillation was made possible by cooperative emergency medical care including air medical transport, despite long distance to the hospital. The patient was a 60-year-old man. Under a diagnosis of AMI, a helicopter emergency medical service (HEMS) with medical staff on board was requested. Although ventricular fibrillation (VF) occurred at the scene, quick and appropriate advanced cardiovascular life support (ACLS) was provided by the attending doctor, leading to the return of heartbeat. Since the patient still exhibited serious bradycardia and cardiac failure, he was airlifted while undergoing transcutaneous pacing. Upon arrival at the hospital, the patient underwent emergency percutaneous coronary intervention (PCI). During the PCI, VF recurred and chest compressions and a total of 17 defibrillations were performed. The PCI was continued with percutaneous cardiopulmonary support (PCPS). The patient survived without sequelae. Smoother cooperation between pre-hospital medical procedures and post-hospital emergency care is considered to be essential for the survival of patients such as this case.
    福島医学会, Dec. 2010, Fukushima Journal of Medical Science, 56(2) (2), 139 - 143, English
    [Refereed]
    Scientific journal

  • Choichiro Tase, Yuko Ono, Arifumi Hasegawa, Yasuhiko Tsukada, Jiro Shimada, YUkihiro Ikegami
    日本航空医療学会, Aug. 2010, Journal of Japanese Society for Aeromedical Services, 11(1) (1), 3 - 8, Japanese, No password
    [Refereed]
    Scientific journal

  • Choichiro Tase, Yuko Ohno, Arifumi Hasegawa, Yasuhiko Tsukada, Jiro Shimada, Yukihiro Ikegami
    Springer, Jun. 2010, Journal of Anesthesia, 24(3) (3), 441 - 446, English
    [Refereed]
    Scientific journal

  • A successful Resuscitation of Acute Myocardial Infarction by Doctor Helicopter System and Subsequent Prompt Treatment.(in Japanese)
    Ono Y, Y Ikegami, J Shimada, A Hasegawa, Y Tsukada, C Tase
    ドクターヘリにより搬送された急性心筋梗塞の1例を経験した。症例は60歳代、男性。強い前胸部痛を自覚し救急車を要請した。救急隊による搬送中にVTが出現したため、救急救命士の判断によりドクターヘリが要請された。搭乗医師が患者に接触した直後にVFに陥った。直ちに二次救命処置を施行し、心拍再開後にヘリで当院へ搬送した。収容後、大動脈バルーンパンピング(IABP)および経皮的ペーシング(TCP)を行いながら緊急心臓カテーテル治療(PCI)を開始した。VFを繰り返し計17回の電気的除細動を行ったが、循環動態が不安定なため経皮的心肺補助(PCPS)下に治療を続行した。#1の再灌流を得た後に治療を終了しCCU入室となった。経過は良好であり、第2病日にPCPSから離脱、第7病日にCCUを退室することができた。本症例はドクターヘリによる適切な初期治療と迅速な搬送が奏功し完全社会復帰できたと考えられた。
    Lead, Japanese Society for Emergency Medicine, 2010, JJSEM, 13(4) (4), 553 - 557, Japanese, No password
    [Refereed]
    Scientific journal

  • CHOICHIRO TASE, YUKO OHNO, ARIFUMI HASEGAWA, YASUHIKO TUKADA, JIRO SHIMADA, YUKIHIRO IKEGAMI
    The purpose of this study is to identify the problems in operating an emergency medical service helicopter with an emergency medicine doctor on board (doctor-helicopter) in Fukushima Prefecture, Japan, which covers wide regions and many rural areas. The study looked at the numbers of flights and patients during the 523 days since the start of the doctor-helicopter service at the Fukushima Medical University Hospital. The items investigated were: number of flights, number of helicopter dispatches per month, number of patients, the hospitals where patients were taken to, the fire department dispatch centers that requested the doctor-helicopter, and the number of times each doctor flew on the helicopter. There were 450 flights. When the service was started, there were a few flights, but they gradually increased. The majority of the flights were to emergency scenes (295), while 75 flights were interfacility transports of critically ill patients, 79 flights were cancelled after take-off, and one flight was for a disaster relief operation. The nature of requests differed greatly depending on the fire department dispatch center requesting the service. The majority of patients were trauma patients (62.2%). Stroke (8.5%) and acute coronary syndrome (5.2%) patients requiring emergency treatment were fewer than anticipated. The final destination hospitals were appropriate hospitals in the region. Because the number of flight doctors is small, the burden on individual doctors is large. A system for early on-site diagnosis and helicopter request by emergency rescue team is required to maintain a high quality of emergency care.
    福島医学会, 2010, Fukushima J Med Sci., 56(1) (1), 71 - 79, English
    [Refereed]
    Scientific journal

  • Shizuko TAKANO, Kozue SUZUKI, Akiko FUJISAKI, Miho FUTAGAMI, Fumihito ITO, Yuko ONO, Shinichi SAI, Makiho KATAKURA, Tomoko OISHI, Kenta SUGAYA, Seiichi ISHIBASHI, Yuuko KOBAYASHI, Michiko ABE, Yuhko DAIGAKU, Satomi MIYAMOTO
    Japan Society for Oriental Medicine, 2005, Kampo Medicine, 56(4) (4), 561 - 566, Japanese, No password
    [Refereed]
    Scientific journal

■ MISC
■ Books And Other Publications
  • Yuko Ono
    Joint work, How to manage the patients with anaphylaxis in the emergency departments., Chugaiigaku. Co, Tokyo, Japan., Dec. 2023, 186–195., Japanese, ISBN: 9784498166646

  • Shigeaki Inoue, Osamu Nishida, Joji Kotani
    Joint work, Burn. Chapter 3 The management of PICS: Featuring case., Japan Medical Journal. Co, Tokyo, Japan, Oct. 2022, p.202–217, Japanese, ●PICS(集中治療後症候群)は,ICU滞在中また退室後,退院後に生じる身体・精神・認知の障害で,患者と家族の人生に大きな影響を与えます。 ●超高齢社会にあって,PICSは,医療問題・社会問題としてとらえるべき課題と言えます。 ●本書では,PICSの概念など総論的な内容にとどまらず,PICSの評価法,予防と早期介入,PICSの症例を紹介し,具体的・実践的にまとめました。 ●PICSの経済的影響,関連病態,先進的かつ革新的なPICS管理法,そして地域連携など,ウィズコロナ・ポストコロナ時代を見据えて,PICSの多様性に応じた対応・対策の一例を紹介しています。 ●集中治療医,救急医,麻酔科医,その他の診療科の医師,看護師,理学療法士,作業療法士,薬剤師,管理栄養士,歯科医師など,PICSを診るすべての医療従事者におすすめです。, ISBN: 9784784959716
    Scholarly book

  • Principal Emergency drugs for residents and nurses. Neuromuscular blocking agents. In: Ono Y, Joji K. Emer-Log. Vol 34 No.5.
    Yuko Ono
    Joint editor, MEDICUS SHUPPAN, Publishers Co., Ltd. Osaka, Japan., Sep. 2021, p.41–45, p.87–95., Japanese

  • In: Nishida O, Joji K, and Inoue S. All about PICS: Q&A 40.
    Yuko Ono
    Contributor, What is the concept of ICU–AW? How is it associated with CIM and CIP?, Chugaiigaku. Co, Tokyo, Japan, Mar. 2020, p.22–27., Japanese, ICU長期入室は,しばしば退院後も生存者に肉体的・精神的ダメージを与え続け,社会復帰を困難にする.この問題をとらえた,集中治療後症候群(post intensive care syndrome,PICS)に関する本格的入門書.本邦の第一人者がおくる本書は,救命率が向上すればするほど要介護者が増加するというパラドキシカルな問題を解決するための羅針盤となろう., ISBN: 9784498166202
    Scholarly book

  • In: Asai T, Ueshima H. Airway management case files for emergency lifesaving technicians
    Ono Y
    Contributor, Case 15. Out-of-Hospital Cardiac Arrest Due to Suffocation: Rethink the airway-related complication in patients with difficult airway (in Japanese).p.98-102; Case 16. Out-of-Hospital Cardiac Arrest in Patients with High Cervical-level Spinal Cord Injury, Chugaiigaku.Co, Tokyo, Japan., Jun. 2019, p 98-106, Japanese, 気道管理は現在,医師のみならず救急救命士にとっても必須の知識となった.適切に気道を確保,呼吸を管理するための選択肢の多さは,そのエキスパートである麻酔科医とほぼ同レベルである.しかし,救急救命士に向けた統一したガイドラインはない.そこで本書では,救急救命士にとって必要な知識と技術を凝縮.現場で起こりうるケースを設定し,その行動手順に沿って解説した.実現場で使える確かな力が身に付く1冊だ.
    Scholarly book

  • In: Makita K, editor. Cardiopulmonary resuscitation.
    Choichiro T, Yukihiro I, Ono Y
    Contributor, Intraoperative cardiopulmonary resuscitation: bradycardia (in Japanese), Kokuseido Co, Tokyo, Dec. 2011, 173-183, Japanese
    Scholarly book

■ Lectures, oral presentations, etc.
  • JAK2/STAT3 pathway as a new molecular therapeutic target for sepsis-associated skeletal muscle atrophy. Poster discussion. emergency medicine and critical care.
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 72nd Annual Meeting of the Japanese Society of Anesthesiologists. June 5, 2025. Kobe, Japan., Jun. 2025, Japanese, the Japanese Society of Anesthesiologists, Kobe, Japan, Japan, Domestic conference

  • Visualization of autophagy activation in skeletal muscle during sepsis.
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 39th Annual Meeting of the Japanese Shock Society. Won the president's award. May 23, 2025. Tokyo, Japan, May 2025, Japanese, Japanese Shock Society, Tokyo, Japan, Japan, Domestic conference
    Oral presentation

  • How to change “why?” to “understood!” in post-intensive care syndrome. Let's learn the basic research methods: Basical research in critical care. symposium.
    Yuko Ono
    The 52nd Annual meeting of the Japanese Society of Intensive Care Medicine. Fukuoka, Japan., Mar. 2025, Japanese, The Japanese Society of Intensive Care Medicine, Fukuoka, Japan, Japan, International conference
    [Invited]
    Nominated symposium

  • Elucidation of the mechanism of sepsis associated skeletal muscle atrophy and pharmacological treatment. The best performance award memorial lecture
    Yuko Ono
    The 29th Annual meeting of the Japanese Endotoxin and Innate Immunity Society, Nov. 2024, Japanese
    [Invited]

  • IL6/STAT3 signaling as a therapeutic target for the sepsis associated skeletal muscle atrophy
    Yuko Ono, Masafumi Saito, Jun Sugiyama, Kazushi Takayama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 29th Annual meeting of the Japanese Endotoxin and Innate Immunity Society., Nov. 2024, Japanese
    Oral presentation

  • IL6/STAT3 signaling as a therapeutic target for the sepsis associated skeletal muscle atrophy.
    Yuko Ono
    The 8th Sinryoku medical association young investigator award presentation, Oct. 2024, Japanese, Sinryoku medical association, Kobe, Japan, Japan, Domestic conference

  • Sepsis activate IL6/STAT3 signaling pathway to induce skeletal muscle atrophy
    Yuko Ono, Masafumi Saito, Kazushi Takayama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    Symposium 12. Hot topics in the basic research of sepsis. The 52nd Annual Meeting of the Japanese Association for Acute Medicine, Oct. 2024, Japanese, the Japanese Association for Acute Medicine, Sendai, Japan, Japan, Domestic conference
    [Invited]
    Nominated symposium

  • The IL/STAT3 pathway activation and the sepsis associated skeletal muscle atrophy
    Yuko Ono, Masafumi Saito, Jun Sugiyama, Kazushi Takayama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 30th Annual Conference on Cytokine Resarch in Surgery and Critical Care, Jul. 2024, Japanese
    Public symposium

  • The molecular mechanism of ICU-acquired weakness
    Yuko Ono
    The 51st Annual meeting of the Japanese Society of Intensive Care Medicine, Mar. 2024, Japanese
    [Invited]
    Nominated symposium

  • The molecular mechanism of ICU-acquired weakness. symposium 12. Inflammation and organ dysfunction: the frontier in basic research.
    Yuko Ono
    The 51st Annual meeting of the Japanese Society of Intensive Care Medicine, Sapporo, Japan., Mar. 2024, Japanese, The Japanese Society of Intensive Care Medicine, Sapporo, Japan., Japan, Domestic conference
    [Invited]
    Nominated symposium

  • Oncostatin M is associated with sepsis induced skeletal muscle atrophy and sepsis severity
    Yuko Ono, Masafumi Saito, Kazushi Takayama, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 28th Annual meeting of the Japanese Endotoxin and Innate Immunity Society, Dec. 2023, Japanese, the Japanese Endotoxin and Innate Immunity Society, Aichi, Japan, Japan
    Oral presentation

  • IL6/STAT3 signaling as a therapeutic target for the thermal burn-induced skeletal muscle atrophy
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The highlight session 11. The 51st Annual Meeting of the Japanese Association for Acute Medicine, Nov. 2023, Japanese, jaam_highlight session_231205.pdf, No password, the Japanese Association for Acute Medicine, Tokyo, Japan, Japan
    [Invited]
    Nominated symposium

  • Sex Disparities in Applied Force on Maxillary Incisors Among Novices During Laryngoscopy Using a High-Fidelity Simulator: A Prospective Observational Study
    Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Jun Sugiyama, Shigeaki Inoue, Joji Kotani
    Poster session. The 51st Annual Meeting of the Japanese Association for Acute Medicine, Nov. 2023, Japanese, jaam_poster_231205.pdf, No password, the Japanese Association for Acute Medicine, Tokyo, Japan, Japan
    Poster presentation

  • Skeletal muscle protein catabolism, protein anabolism, and myogenesis after various types of insults.
    Yuko Ono
    The 37th Japan Shock Society Annual Meeting, Aug. 2023, Japanese, Japan Shock Society, Aichi, Japan, Domestic conference
    [Invited]
    Nominated symposium

  • STAT3 signaling as a therapeutic target for the thermal burn-induced skeletal muscle wasting. Won the president's award.
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    The 29th annual conference on cytokine research in surgery and critical care. Tokyo, Japan., Jul. 2023, Japanese, abst230706_cytkine.pdf, No password, Tokyo, Japan, Japan, Domestic conference
    Oral presentation

  • Symposium 2. Emergency airway management in patients with full stomach outside operating room.
    Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Joji Kotani
    The 6th Annual Meeting of Japanese Airway Management Society. Omiya, Japan., Jul. 2023, Japanese, abst230701.pdf, No password, Omiya, Japan, Japan, Domestic conference
    [Invited]
    Nominated symposium

  • C188-9, a specific inhibitor of STAT3 signaling, ameliorates thermal burn-induced skeletal muscle wasting in mice.
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    Won the Award for best presentation. The 70th Annual Meeting of the Japanese Society of Anesthesiologists. June 1, 2023. Kobe, Japan., Jun. 2023, Japanese, jsa70_abstractYO20230511.pdf, No password, Domestic conference
    Oral presentation

  • Thermal burn injury activates proteolytic pathway, but not apoptotic pathway to induce skeletal muscle in mice.
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 38th Annual Meeting of Japanese Society for Clinical Nutrition and Metabolism. May 9, 2023. Kobe, Japan., May 2023, Japanese, abstract_YO_JSPEN_230509.pdf, No password, Domestic conference

  • Yuko Ono, Masafumi Saito, Kazuaki Shinohara, Yudai Iwasaki, Shigeaki Inoue, Joji Kotani.
    Gender disparities in, first authorship a, hree medical universities in, an area affected by the Great East Japan Earthquake
    KOBE UNIVERSITY RESEARCH CENTER FOR URBAN SAFETY AND SECURITY. The 3rd disaster restoration and disaster science symposium. January 21, 2023. Kobe, Japan., Jan. 2023, Japanese, SymposiumDetails2023.pdf, No password, Domestic conference
    [Invited]

  • Plasma from burned mice induces protein catabolism that promotes C2C12 myotube atrophy through STAT3 signaling pathway.
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
    The 27th Japanese Endotoxin and Innate Immunity Society. November 26, 2022. Hiroshima, Japan., Nov. 2022, Japanese, JEIIS271117_YO.pdf, No password
    Oral presentation

  • Gender disparities in first authorship at three medical universities in an area affected by the Great East Japan Earthquake.
    Yuko Ono, Masafumi Saito, Kazuaki Shinohara, Yudai Iwasaki, Shigeaki Inoue, Joji Kotani
    The 50th Annual Meeting of the Japanese Association for Acute Medicine., Oct. 2022, Japanese, O146-01.pdf, No password, the Japanese Association for Acute Medicine, Tokyo, Japan, Japan

  • Is a Physician-Scientist Career Right for You? Sponsored Symposium.
    Yuko Ono
    The 37th Annual Meeting of the Japanese Society for Critical Care Medicine, Sep. 2022, Japanese, JSCCM_Sponsored Symposium_220917.pdf, No password, the Japanese Society for Critical Care Medicine, Tokyo, Japan, Japan
    [Invited]
    Nominated symposium

  • Plasma from mice with thermal burn injury induces C2C12 myotube atrophy and protein degradation
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    The 37th Annual Meeting of the Japanese Society for Critical Care Medicine, Sep. 2022, Japanese, JSCCM_oral_presentation_220917.pdf, No password, the Japanese Society for Critical Care Medicine, Tokyo, Japan, Japan, Domestic conference
    Oral presentation

  • Emergency airway management outside the operating room in the era of COVID-19
    Yuko Ono, Shigeaki Inoue, Joji Kotani
    The 5th Annual Meeting of the Japanese Airway Management Society, Jul. 2022, Japanese, The 5th Annual Meeting of the Japanese Airway Management Society, Tokyo, Japan, Japan, Domestic conference
    [Invited]
    Invited oral presentation

  • Lower maximum forces on oral structures when using gum-elastic bougie than when using endotracheal tube and stylet during both direct and indirect laryngoscopy by novices: a crossover study using a high-fidelity simulator
    Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Shigeaki Inoue, Joji Kotani
    JAMS best paper award memorial lecture. The 17th Annual Meeting of The Japanese Association for Medical Simulation. Tokyo, Japan., Mar. 2022, Japanese, jams2022.pdf, No password
    [Invited]
    Invited oral presentation

  • Impact of closure of the in-house psychiatric care unit on prehospital and emergency ward length of stay and disposition locations in patients who attempted suicide: A retrospective before-and-after cohort study at a community hospital in Japan.
    Yuko Ono, Nozomi Ono, Shigeaki Inoue, Joji Kotani, Kazuaki Shinohara
    Panel discussion:Challenge to Change, multidisciplinary collaboration. The 49th Annual Meeting of the Japanese Association for Acute Medicine, Nov. 2021, Japanese, abstractInfo.pdf, No password, The Japanese Association for Acute Medicine, Tokyo, Japan, Japan
    Public symposium

  • Thermal burn injury increases STAT3 signaling pathway activation, following to induce skeletal muscle atrophy in mice
    Yuko Ono, Masafumi Saito, Nobuto Nakanishi, Yusuke Miyazaki, Naoki Moriyama, Yoshihisa Fujinami, Shigeaki Inoue, Joji Kotani
    16th Meeting of the International Endotoxin and Innate Immunity Society & 26th Japanese Endotoxin and Innate Immunity Society., Oct. 2021, English, Kobe, Japan, Japan
    Oral presentation

  • Thermal burn injury induce skeletal muscle atrophy through STAT3 signaling pathway in mice.
    Yuko Ono, Masafumi Saito, Yoshihisa Fujinami, Yusuke Miyazaki, Nobuto Nakanishi, Naoki Moriyama, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    The 27th Conference on Cytokine Research in Surgery and Critical Care, Oct. 2021, Japanese, Kobe, Japan
    Oral presentation

  • Impact of emergency physician-staffed ambulances on preoperative time course and survival among injured patients requiring emergency surgery or transarterial embolization: A retrospective cohort study at a community emergency department in Japan.
    Yuko Ono, Yudai Iwasaki, Takaki Hirano, Katsuhiko Hashimoto, Takeyasu Kakamu, Shigeaki Inoue, Joji Kotani, Kazuaki Shinohara
    The 29th Hyogo prefecture emergency and critical care seminar, Oct. 2021, Japanese, Kobe, Japan, Japan
    Oral presentation

  • Airway management skill up seminar -How to protect patients from airway related adverse events at emergency department-
    Yuko Ono
    The 3rd Kobe emergency and critical care seminar, Aug. 2021, Japanese, Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan, Japan
    [Invited]
    Invited oral presentation

  • Factors associated with successful publication of research abstracts presented at the Japanese Society of Anesthesiologists annual meetings 2015–2017: a bibliometric analysis.
    Yuko Ono, Masafumi Saito, Chiaki Shinohara, Kazuaki Shinohara, Shigeaki Inoue, Joji Kotani
    The 68th Annual Meeting of the Japanese Society of Anesthesiologists., Jun. 2021, Japanese, jsa68_0619_unit_prog_ext_ja.pdf, No password, The Japanese Society of Anesthesiologists, Kobe, Japan, Japan
    Poster presentation

  • Burn injury induces skeletal muscle atrophy via STAT3 pathway in mice.
    Yuko Ono, Masafumi Saito, Yoshihisa Fujinami, Yusuke Miyazaki, Kazuho Sakamoto, Shigeaki Inoue, Joji Kotani
    The 35th Annual Meeting of the Japanese Shock Society. The chairman's award nominate., May 2021, Japanese, Tokyo, Japan, Japan, International conference
    Oral presentation

  • How emergency physician works
    Yuko Ono
    In-company workshop, Asahi Kasei Pharma Kobe branch, Kobe Japan, Apr. 2021, Japanese
    Public discourse

  • Lower maximum forces on oral structures when using gum-elastic bougie than when using endotracheal tube and stylet during both direct and indirect laryngoscopy by novices: a crossover study using a high-fidelity simulator
    Yuko Ono, Kazuaki Shinohara, Jiro Shimada, Shigeaki Inoue, Joji Kotani
    The 48th Annual Meeting of the Japanese Association for Acute Medicine, Nov. 2020, Japanese, jaam2020YO.pdf, No password, The Japanese Association for Acute Medicine, Gifu,Japan, Japan, Domestic conference
    Oral presentation

  • Lipopolysaccharide inhibits phosphorylation of Akt and S6k in mice skeletal muscle
    Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yoshihisa Fujinami, Shigeaki Inoue, Joji Kotani
    The 24th Annual Meeting of Japan Society of Critical Care for Endotoxemia, Feb. 2020, Japanese

  • Impact of the academic calendar cycle on survival outcome of injured patients: A retrospective cohort study at a community emergency department in Japan.
    Yuko Ono, Takeyasu Kakamu, Tokiya Ishida, Tetsu Sasaki, Shigeaki Inoue, Joji Kotani, Kazuaki Shinohara
    The 47th Annual Meeting of the Japanese Association for Acute Medicine., Oct. 2019, Japanese, jaam2019_YO.pdf, No password, The Japanese Association for Acute Medicine., Tokyo, Japan., Domestic conference
    Oral presentation

  • Expert performed endotracheal intubation related complications in trauma patients: incidence, possible risk factors, and outcomes.
    Yuko Ono, Takeyasu Kakamu, Hiroaki Kikuchi, Yusuke Mori, Yui Watanabe, Kazuaki Shinohara, Shigeaki Inoue, Joji Kotani
    The 34th Annual meeting of the Japan Society for Critical Care Medicine., Sep. 2019, Japanese, The Japan Society for Critical Care Medicine, Osaka, Japan., Domestic conference
    Oral presentation

  • TAK-242, a specific inhibitor of Toll like receptor 4 signaling ameliorates sepsis induced muscle wasting in mice.
    Yuko Ono, Yuko Maejima, Shoichiro Horita, Kenju Shimomura, Shigeaki Inoue, Joji Kotani
    The 34th Annual Meeting of the Japanese Shock Society. The chairman's award nominate., Jul. 2019, Japanese, the Japanese Shock Society., Mie, Japan, Domestic conference
    Invited oral presentation

  • Toll like receptor4pathway mediates both skeletal muscle myogenesis and proteolysis.
    Yuko Ono, Sigeaki Inoue, Masafumi Saito, Yoshihisa Fujinami, Joji Kotani
    The 56th Annual Meeting of the Japanese Society for Surgical Metabolism and Nutrition, Jul. 2019, Japanese, the Japanese Society for Surgical Metabolism and Nutrition., Kobe, Japan, Domestic conference
    [Invited]
    Nominated symposium

  • Drug Exploration for Sepsis-Induced Skeletal Muscle Atrophy.
    Yuko Ono, Yuko Maejima, Shoichiro Horita, Kenju Shimomura, Shigeaki Inoue, Joji Kotani
    The 66th Annual Meeting of the Japanese Society of Anesthesiologists, May 2019, Japanese, Japanese Society of Anesthesiologists, Kobe, Domestic conference
    Invited oral presentation

  • TAK-242, a specific inhibitor of Toll like receptor 4 signaling ameliorates sepsis induced muscle wasting in mice.
    Yuko Ono, Yuko Maejima, Shoichiro Horita, Kenju Shimomura, Shigeaki Inoue, Joji Kotani
    The 66th Annual Meeting of the Japanese Society of Anesthesiologists, May 2019, Japanese, jsa2019_YO.pdf, No password, Japanese Society of Anesthesiologists, Kobe, Won the award for the best presentation., Domestic conference
    Invited oral presentation

  • Work-life balance among medical professionals
    ONO Yuko
    FMU café., Feb. 2019, Japanese, Fukushima Medical University, Fukushima, 1H seminar, physician, nurses, and students, Domestic conference
    [Invited]
    Public discourse

  • Work-life conflict, gender-based discrimination, and their associations among professionals in a medical university and affiliated hospitals in Japan: A cross-sectional study
    Yuko Ono, Aya Goto, Yuko Maejima, Ikuko Maruyama, Tomoko Suzuki, Yayoi Shikama, Hiromi Yoshida-Komiya
    The 12th Annual meeting of the Japanese Association for Gender-Specific Medicine, Jan. 2019, Japanese, Omiya, Japan, Domestic conference
    Poster presentation

  • Out-of-hospital endotracheal intubation experience, confidence and confidence-associated factors among Northern Japanese emergency life-saving technicians: a population-based cross-sectional study.
    Yuko Ono, Koichi Tanigawa, Kazuaki Shinohara, Ken Iseki
    The 2nd Airway Management Conference, Jan. 2019, Japanese, Tokyo, Japan., Domestic conference
    Oral presentation

  • Out-of-hospital endotracheal intubation experience, confidence and confidence-associated factors among Northern Japanese emergency life-saving technicians: a population-based cross-sectional study. Panel discussion: Epidemiological studies in emergency me
    Yuko Ono, Koichi Tanigawa, Kazuaki Shinohara, Ken Iseki
    The 46th Annual Meeting of the Japanese Association for Acute Medicine., Nov. 2018, Japanese, jaam2018.pdf, No password, Japanese Association for Acute Medicine., Yokohama, Japan., Domestic conference
    Public symposium

  • 敗血症誘発性骨格筋萎縮の新規薬物治療の可能性. パネルディスカッション: PICSからPACSへ ~救急から集中治療後症候群を科学する~.
    大野雄康, 前島裕子, 下村健寿
    第46回日本救急医学会総会・学術集会., Nov. 2018, English, jaam2018_YO_2.pdf, No password, 日本救急医学会, 横浜、日本, Domestic conference
    Public symposium

  • トンネル内での溶接機による集団一酸化炭素中毒
    佐藤 ルブナ, 三澤 友誉, 大久保 怜子, 反町 光太朗, 鈴木 剛, 大野 雄康, 塚田 泰彦, 小野寺 誠, 島田 二郎, 田勢 長一郎, 伊関 憲
    中毒研究, Sep. 2018, Japanese, (株)へるす出版

  • Work life coflict ant its associating factors in a medical university in Japan.
    Yuko Ono, Aya Goto, Yuko Maejima, Ikuko Maruyama, Tomoko Suzuki, Hiromi Komiya
    Fukushima Medical University Summer Poster Session, Jul. 2018, Japanese, Fukushima Medical Society, Fukushima Medical University, Fukushima, Japan., Domestic conference
    Poster presentation

  • Expert-Performed Endotracheal Intubation-Related Complications in Trauma Patients: Incidence, Possible Risk Factors, and Outcomes in the Prehospital Setting and Emergency Department
    Yuko Ono, Takeyasu Kakamu, Hiroaki Kikuchi, Yusuke Mori, Yui Watanabe, Kazuaki Shinohara
    The 65th Annual Meeting of the Japanese Society of Anesthesiologists, May 2018, Japanese, jsa2018YO.pdf, No password, The Japanese Society of Anesthesiologists, Yokohama, Japan, Domestic conference
    Invited oral presentation

  • インターネット上で購入した薬剤を使用した三環形抗うつ薬中毒の一例
    佐藤 ルブナ, 三澤 友誉, 反町 光太朗, 大久保 怜子, 鈴木 剛, 大野 雄康, 塚田 泰彦, 小野寺 誠, 伊関 憲
    日本臨床救急医学会雑誌, Apr. 2018, Japanese, (一社)日本臨床救急医学会

  • Lipopolysaccharide inhibits skeletal myogenesis: The possible novel molecular mechanism of ICU acquired weakness. The Up to date of etiology and treatment of ICU-acquired weakness. Symposium.
    Yuko Ono
    The 45th Annual Meeting of the Japanese Society of Intensive Care Medicine., Feb. 2018, Japanese, jsicm2018YO.pdf, No password, The 45th Annual Meeting of the Japanese Society of Intensive Care Medicine., Tokyo, Japan., Lipopolysaccharide (LPS) はグラム陰性菌細胞壁の主要な構成成分であり、敗血症の引き金となる。敗血症はICU aquired weaknessの最大の原因とされている。敗血症サバイバーが、単なる廃用症候群では説明のつかない重篤な筋力の低下を起こし、その結果離床が妨げられる事は実臨床でもしばしば経験する。しかしながら、この機序は十分に知られていなかった。最近、我々はLPSが骨格筋前駆細胞に作用し、骨格筋再生能を低下させる生命現象、およびその分子メカニズムを見出した (Ono Y and Sakamoto K, PLoS One 2017)。 方法: 確立した筋新生モデルであるマウス筋芽細胞C2C12をconfluentになるまで10%ウシ胎児血清含有成長培地で培養後、LPS (0.1 または 1 μg/mL) およびToll like receptor (TLR) 4 signalの特異的阻害剤であるTAK242 (1 μM)、およびtumor necrosis factor (TNF) α中和抗体 (5 μg/mL) 存在下/非存在下で2%ウマ血清含有分化培地に組成を変更し、骨格筋新生を誘導した。骨格筋特異的タンパク質であるミオシン重鎖、正, Domestic conference
    [Invited]
    Oral presentation

  • Human and equipment resources for difficult airway management, airway education programs, and capnometry use in Japanese emergency departments: A nationwide cross-sectional study
    Yuko Ono, Koichi Tanigawa, Kazuaki Shinohara, Tetsuhiro Yano, Kotaro Sorimachi, Jiro Shimada
    The 64th Annual Meeting of the Japanese Society of Anesthesiologists, Jun. 2017, Japanese, 2017_jsaYO_2P167-71.pdf, No password, Japanese Society of Anesthesiologists, Kobe, Japan, Domestic conference
    Oral presentation

  • Lipopolysaccharide Inhibits Myogenic Differentiation of C2C12 Myoblasts Through the Toll-like Receptor 4 Nuclear Factor-κB Signaling Pathway
    Yuko Ono, Kazuho Sakamoto
    The 64th Annual Meeting of the Japanese Society of Anesthesiologists, Jun. 2017, Japanese, 2017_Q06-05.pdf, No password, The Japanese Society of Anesthesiologists, Kobe, Japan, Domestic conference
    Invited oral presentation

  • Are supraglottic airway device appropriately used in Japanese emergency departments and Intensive care units?
    Yuko Ono, Kazuaki Shinohara
    The 44th Annual Meeting of the Japanese Society of Intensive Care Medicine, Mar. 2017, Japanese, jsicm44.pdf, No password, The 44th Annual Meeting of the Japanese Society of Intensive Care Medicine, Sapporo, Japan., Domestic conference
    [Invited]
    Invited oral presentation

  • Off hour effect on airway related adverse events in trauma patientswith a predicted difficult airway.
    大野雄康, 杉山拓也, 千田康之, 菊地紘彰, 岩崎夢大, 谷川攻一, 篠原一彰
    第44回日本救急医学会総会・学術集会, Nov. 2016, English, jaam2016.pdf, No password, 日本救急医学会, グランドプリンスホテル新高輪・国際館パミール、東京, Domestic conference
    Oral presentation

  • Are prehospital airway management resources compatible with difficult airway algorithms? A nation-wide cross-sectional study of helicopter emergency medical services in Japan
    Ono Y, K Shinohara, A Goto, T Yano, L Sato, C Tase
    The 63rd Annual Meeting of the Japanese Society of Anesthesiologists, poster discussion., May 2016, Japanese, jsa2016_PD1-05.pdf, No password, Japanese Society of Anesthesiologists, Fukuoka, Japan., Domestic conference
    Poster presentation

  • フライトドクター・ナースに必須なoff the job trainingは何か?:ドクターヘリ基地病院を対象にした全国調査.
    大野雄康, 矢野徹宏, 宮崎博之, 佐藤ルブナ, 島田二郎, 田勢長一郎
    第19回日本臨床救急医学会総会・学術集会., May 2016, Japanese, 日本臨床救急医学会, 郡山市, ビッグパレットふくしま, Domestic conference
    Oral presentation

  • LIPOPOLYSACCHARIDE INHIBITS MOUSE MYOGENIC DIFFERENTIATION BY INCREASING MYOSTATIN
    Yuko Ono, Junko Kimura, Kazuho Sakamoto
    The 89th Annual Meeting of the Japanese Pharmacological Society, Mar. 2016, Japanese, The Japanese Pharmacological Society, PACIFICO Yokohama, Conference Center, Yokohama, Japan., Domestic conference
    Oral presentation

  • Vessel & Miscellaneous: Chair
    Yuko Ono
    The 89th Annual Meeting of the Japanese Pharmacological society, Mar. 2016, Japanese, Kunio Ishii, Ph.D., PACIFICO Yokohama Conference Center, Yokohama, Japan, Domestic conference
    Others

  • The effect of lipopolysaccharide on the myogenesis of murine C2C12 myoblasts
    Ono Y, Kimura J, Sakamoto K
    Muscle Physiology Conference, Dec. 2015, Japanese, The Jikei University School of Medicine, Tokyo, Japan., Domestic conference
    Oral presentation

  • 気道管理アルゴリズムは病院前でも実施可能か?:横断研究
    大野雄康, 後藤あや, 矢野徹宏, 佐藤ルブナ, 篠原一彰, 宮崎博之, 島田二郎, 田勢長一郎
    第22回日本航空医療学会, Nov. 2015, Japanese, 日本航空医療学会, 前橋テルサ、前橋市、群馬, Domestic conference
    Oral presentation

  • フライトドクターはどのような専門資格を持っているか 横断研究
    佐藤 ルブナ, 大野 雄康, 後藤 あや, 矢野 徹宏, 篠原 一彰, 宮崎 博之, 島田 二郎, 田勢 長一郎
    日本航空医療学会雑誌, Oct. 2015, Japanese, (一社)日本航空医療学会

  • Lipopolysaccharideはマウス筋芽細胞C2C12の筋分化を抑制する
    大野雄康, 木村純子, 坂本多穂
    第66回日本薬理学会北部会, Sep. 2015, Japanese, 公益社団法人 日本薬理学会, 富山, Domestic conference
    Oral presentation

  • The off-hour effect on trauma patients requiring subspecialty intervention at a community hospital in Japan: a retrospective cohort study
    Ono Y, T Ishida, Y Iwasaki, Y Chida, T Sato, T Sugiyama, C Tase, K Shinohara
    The 29th Annual Meeting of the Japanese Association for Acute Medicine, May 2015, Japanese, Japanese Association for Acute Medicine, Tohoku Branch, Fukushima, Domestic conference
    Oral presentation

  • Direct and indirect laryngoscope: to be a skilled two-sword fencer.
    Yuko Ono
    The 29th Annual Meeting of the Japanese Association for Acute Medicine, May 2015, Japanese, Japanese Association for Acute Medicine, Tohoku Branch, Fukushima, Japan, Domestic conference
    [Invited]
    Invited oral presentation

  • Emergency endotracheal intubation associated adverse event in patients with severe bronchial asthma: Can anesthesiologists attenuate the risk?
    Yuko Ono, Hiroaki Kikuchi, Katsuhiko Hashimoto, Tetsu Sasaki, Choichiro Tase, Kazuaki Shinohara
    The 62nd Annual Meeting of the Japanese Society of Anesthesiologists, May 2015, Japanese, jsa2015_Q09.pdf, No password, Japanese Society of Anesthesiologists, Kobe, Japan, Domestic conference
    Oral presentation

  • Airway management in a patient with nuchal, interspinous, and flavum ligament rupture by a sickle: a case report.
    Ono Y, R Okubo, K Sorimachi, T Suzuki, Y Tsukada, K Shinohara, C Tase
    The 24th Annual Meeting of The Japanese Society of Intensive Care Medicine, Tohoku Branch, May 2015, Japanese, The Japanese Society of Intensive Care Medicine, Tohoku Branch, Fukushima, Japan., Domestic conference
    Oral presentation

  • Airway scope ® was useful in awake endotracheal intubation in patient with severe inhalation burn
    Y Ono, Y Abe, C Nemoto, J Shimada, K Shinohara, C Tase
    The 42nd Annual Meeting of The Japanese Society of Intensive Care Medicine, Feb. 2015, Japanese, jsicm2015.pdf, No password, The Japanese Society of Intensive Care Medicine, Tokyo, Japan., Domestic conference
    Poster presentation

  • 気管支喘息発作における換気不能/挿管不能と誤診
    大野 雄康, 橋本 克彦, 石井 惇也, 篠原 一彰, 田勢 長一郎
    第42回日本救急医学会総会・学術集会, Oct. 2014, Japanese, jaam2013.pdf, No password, 日本救急医学会, 福岡, Domestic conference
    Oral presentation

  • If you are asked to see the patient on the commercial airline.
    ONO Yuko
    FMU English café., Oct. 2014, English, Office for Gender Equality Support,, Fukushima Medical University, Fukushima, Japan, Domestic conference
    [Invited]
    Public discourse

  • Surgical airways for trauma patients in an emergency surgical setting: Twelve year's experience at a teaching hospital in Japan
    Ono Y, H Yokoyama, A Matsumoto, Y Kumada, K Shinohara, C Tase
    Fukushima Medical Univ. Summer poster session., Jul. 2014, Japanese, Fukushima Medical University, Fukushima, Japan., Domestic conference
    Poster presentation

  • Cannot intubate/cannot ventilate and misdiagnosis in bronchial asthma attacks
    J Ishii, Y Ono, K Hashimoto, K Shinohara, C Tase
    The 28th Annual Meeting of Japanese Association for Acute Medicine, Tohoku Branch, Jul. 2014, Japanese, Japanese Association for Acute Medicine, Tohoku Branch, Iwate, Japan., Domestic conference
    Oral presentation

  • Massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case report
    Ono Y, Y Okubo, K Hashimoto, K Shinohara, H Odajima, C Tase
    The 23rd Annual Meeting of The Japanese Society of Intensive Care Medicine, Tohoku Branch., Jun. 2014, Japanese, The Japanese Society of Intensive Care Medicine, Tohoku Branch., Yamagata, Japan., Domestic conference
    Oral presentation

  • Surgical airways for trauma patients in an emergency surgical setting: Twelve year's experience at a teaching hospital in Japan
    Ono Y, H Yokoyama, A Matsumoto, Y Kumada, K Shinohara, C Tase
    The 61st Annual Meeting of Japanese Society of Aneshesiologists., May 2014, Japanese, jsa2014_YO.pdf, No password, Japanese Society of Aneshesiologists, Yokohama, Japan., Domestic conference
    Poster presentation

  • 四輪車乗員におけるシートベルト着用の効果について その効果と問題点
    篠原 一彰, 佐藤 哲也, 橋本 克彦, 佐々木 徹, 大野 雄康, 伊藤 文人, 岡田 恵, 石田 時也, 松本 昭憲
    第41回 日本救急医学会総会・学術集会, Oct. 2013, English, 堀 進悟, 東京, International conference
    Oral presentation

  • 四輪車乗員におけるシートベルト着用の効果について その効果と問題点
    篠原 一彰, 佐藤 哲也, 橋本 克彦, 佐々木 徹, 大野 雄康, 伊藤 文人, 岡田 恵, 石田 時也, 松本 昭憲
    第41回 日本救急医学会総会・学術集会, Oct. 2013, Japanese, 堀 進悟, 東京, Domestic conference
    Oral presentation

  • Activation intervals for a helicopter emergency medical service in Japan.
    Ono Y, Y Tsukada, J Shimada, Y Ikegami, K Shinohara, C Tase
    The 41st Annual Meeting of the Japanese Association for Acute Medicine, Oct. 2013, Japanese, jaam_heli_2013.pdf, No password, Japanese Association for Acute Medicine, Tokyo, Japan, Domestic conference
    Oral presentation

  • Time study for emergency trauma surgery: What affects preoperative elapsed time?
    Ono Y, H Yokoyama, A Matsumoto, Y Kumada, K Shinohara, C Tase
    The 3rd Annual Meeting of Japanese Society of Aneshesiologists, Hokkaido-Tohoku Branch., Sep. 2013, Japanese, jsatohoku2013_YO.pdf, No password, Japanese Society of Aneshesiologists, Hokkaido-Tohoku Branch., Sendai, Japan., Domestic conference
    Poster presentation

  • 死亡時画像診断(Ai)にLUCAS2が有効であった搬入時心肺停止の1例
    松本 昭憲, 石田 時也, 岡田 恵, 橋本 克彦, 伊藤 文人, 篠原 一彰, 大野 雄康
    第27回東北救急医学会総会, Jun. 2013, Japanese, 廣瀬保夫, 新潟, Domestic conference
    Oral presentation

  • ERでの血液培養と予後との関連について
    松本 昭憲, 石田 時也, 篠原 一彰, 岡田 恵, 橋本 克彦, 大野 雄康, 斎藤 至, 伊藤 文人
    第40回 日本救急医学会総会・学術集会, Nov. 2012, Japanese, 中谷 壽男, 京都, Domestic conference
    Oral presentation

  • 福島県における災害復興支援
    島田二郎, 田勢長一郎, 池上之浩, 長谷川有史, 塚田泰彦, 阿部良伸, 大野雄康, 鈴木剛
    第40回日本救急医学会総会・学術集会, Nov. 2012, Japanese, 京都市, Domestic conference
    Public symposium

  • 当院に救急搬送された原発避難者と非避難者で、患者背景に違いはあるか?
    岡田 恵, 橋本 克彦, 齋藤 至, 大野 雄康, 伊藤 文人, 石田 時也, 松本 昭憲, 篠原 一彰
    第40回 日本救急医学会総会・学術集会, Nov. 2012, Japanese, 中谷 壽男, Domestic conference
    Oral presentation

  • 当院におけるウツタイン様式を用いた病院外心停止(OHCPA)の検討
    大久保怜子, 鈴木剛, 大野雄康, 阿部良伸, 根本千秋, 塚田泰彦, 長谷川有史, 島田二郎, 池上之浩, 田勢長一郎
    第26回東北救急医学会総会, Jun. 2012, Japanese, 仙台市, Domestic conference
    Oral presentation

  • 新しい骨髄穿刺針EZ-IOの使用経験
    島田二郎, 田勢長一郎, 大野雄康
    第15回日本臨床救急医学会, Jun. 2012, Japanese, 熊本県, Domestic conference
    Oral presentation

  • 東日本大震災災害急性期における当院救命救急センターの状況
    大野雄康, 池上之浩, 島田二郎, 塚田泰彦, 長谷川有史, 阿部良伸, 田勢長一郎
    第39回日本集中治療医学会, Feb. 2012, Japanese, 日本集中治療医学会, 千葉県, Domestic conference
    Oral presentation

  • 当院における重症熱傷治療の検討
    川島一公, 大野雄康, 池上之浩, 島田二郎, 長谷川有史, 塚田泰彦, 阿部良伸, 田勢長一郎
    第39回日本集中治療医学会, Feb. 2012, Japanese, 千葉県, Domestic conference
    Oral presentation

  • 破傷風の自律神経障害に対しデクスメデトミジンが有効と考えられた一例
    阿部良伸, 池上之浩, 塚田泰彦, 島田二郎, 長谷川有史, 大野雄康, 田勢長一郎
    第39回日本集中治療医学会, Feb. 2012, Japanese, 千葉県, Domestic conference
    Poster presentation

  • 心停止症例に対するドクターヘリの有用性
    大野雄康, 池上之浩, 島田二郎, 塚田泰彦, 長谷川有史, 阿部良伸, 田勢長一郎
    日本蘇生学会第30回大会, Nov. 2011, Japanese, 福島, Domestic conference
    Oral presentation

  • 津波による溺水で重篤な呼吸不全(津波肺)を来した2例
    黒岩大地, 大野雄康, 池上之浩, 島田二郎, 塚田泰彦, 長谷川有史, 阿部良伸, 田勢長一郎
    日本蘇生学会第30回大会, Nov. 2011, Japanese, 福島, Domestic conference
    Others

  • 原発事故におけるドクターヘリ運航の問題点
    塚田泰彦, 大野雄康, 阿部良伸, 長谷川有史, 池上之浩, 島田二郎, 田勢長一郎
    日本蘇生学会第30回大会, Nov. 2011, Japanese, 福島, Domestic conference
    Oral presentation

  • 原子力災害におけるドクターヘリ運行(放射線防護の観点から)
    長谷川有史, 鈴木剛, 大野雄康, 阿部良伸, 塚田泰彦, 島田二郎, 池上之浩, 田勢長一郎, 河村孝広, 高橋宏之, 兵藤敬, 児玉三直
    第18回日本航空医療学会総会, Nov. 2011, Japanese, 長崎県, Domestic conference
    Oral presentation

  • 福島原発事故におけるドクターヘリ活動の問題点
    田勢長一郎, 塚田泰彦, 長谷川有史, 島田二郎, 大野雄康, 高橋宏之, 石黒健司
    第18回日本航空医療学会総会, Nov. 2011, Japanese, 長崎県, Domestic conference
    Oral presentation

  • 有機リン中毒患者における血中アミラーゼ値測定の有用性の検討
    加藤由理, 大野雄康, 池上之浩, 島田二郎, 長谷川有史, 塚田泰彦, 阿部良伸, 田勢長一郎
    第25回東北救急医学会総会, Nov. 2011, Japanese, 山形, Domestic conference
    Others

  • 胸腔ドレナージにもかかわらず、緊張性気胸が再発したドクターヘリ搬送交通外傷の1例
    島田二郎, 田勢長一郎, 池上之浩, 長谷川有史, 塚田泰彦, 阿部良伸, 大野雄康
    第25回東北救急医学会総会, Nov. 2011, Japanese, 山形, Domestic conference
    Others

  • Our Intensive care unit admission during great east japan earthquake
    Ono Y, Y Ikegami, J Shimada, Y Tsukada, A Hasegawa, S Ishi, Y Abe, C Tase
    The 25th Japanese Association for Acute Medicine, Tohoku Branch, Nov. 2011, Japanese, Japanese Association for Acute Medicine, Tohoku Branch, Yamagata, Japan., Domestic conference
    Oral presentation

  • 津波による溺水で重篤な呼吸不全(津波肺)を来した2例
    黒岩大地, 大野雄康, 池上之浩, 島田二郎, 塚田泰彦, 長谷川有史, 阿部良伸, 田勢長一郎
    第25回東北救急医学会総会, Nov. 2011, Japanese, 山形, Domestic conference
    Oral presentation

  • 福島原発事故におけるドクターヘリ活動の問題点
    田勢長一郎, 塚田泰彦, 長谷川有史, 島田二郎, 大野雄康, 阿部良伸, 池上之浩
    第25回東北救急医学会総会, Nov. 2011, Japanese, 山形, Domestic conference
    Others

  • 東日本大震災時のドクターヘリ活動
    田勢長一郎, 塚田泰彦, 長谷川有史, 島田二郎, 大野雄康, 阿部良伸, 池上之浩
    第25回東北救急医学会総会, Nov. 2011, Japanese, 山形, Domestic conference
    Oral presentation

  • イヌ咬傷Capnocytophaga canimorsusによる重篤な敗血症の1救命例
    阿部良伸, 池上之浩, 島田二郎, 長谷川有史, 塚田泰彦, 石井証, 大野雄康, 田勢長一郎
    第39回日本救急医学会総会・学術集会, Oct. 2011, Japanese, 東京都, Domestic conference
    Poster presentation

  • Helicopter emergency medical services (doctor-helicopters) for trauma patients
    Ono Y, Y Ikegami, J Shimada, A Hasegawa, Y Tsukada, Y Abe, S Ishi, C Tase
    The 39th Annual Meeting of Japanese Association for Acute Medicine, Oct. 2011, Japanese, Japanese Association for Acute Medicine, Tokyo, Japan., Domestic conference
    Oral presentation

  • 福島医大緊急被ばく医療班の立ち上げ
    長谷川有史, 島田二郎, 塚田泰彦, 鈴木剛, 大野雄康, 阿部良伸, 池上之浩, 田勢長一郎
    第39回日本救急医学会総会・学術集会, Oct. 2011, Japanese, 東京都, Domestic conference
    Poster presentation

  • 災害時の一酸化炭素中毒症例
    島田二郎, 大野雄康, 田勢長一郎
    第33回日本中毒学会総会・学術集会, Jul. 2011, Japanese, 岐阜県, Domestic conference
    Oral presentation

  • Acute laryngitis in a child: A case report
    Ono Y, Ikegami Y, Tsukada Y, Shimada J, Hasegawa A, Ishii S, Y Abe, Tase C
    The 20th Annual Meeting of The Japanese Society of Intensive Care Medicine, Tohoku Branch., Jul. 2011, Japanese, The Japanese Society of Intensive Care Medicine, Tohoku Branch., Hirosaki, Aomori, Japan., Domestic conference
    Oral presentation

  • 重篤な脳膿瘍を合併した脾摘後劇症型感染症(OPSI)の1例
    五十嵐亮, 大野雄康, 池上之浩, 島田二郎, 長谷川有史, 塚田泰彦, 阿部良伸, 田勢長一郎
    第14回日本臨床救急医学会総会・学術集会, Jun. 2011, Japanese, 札幌市, Domestic conference
    Others

  • 急性トリカブト中毒の治療経験
    菅野優紀, 大野雄康, 池上之浩, 島田二郎, 長谷川有史, 塚田泰彦, 阿部良伸, 田勢長一郎
    第14回日本臨床救急医学会総会・学術集会, Jun. 2011, Japanese, 札幌市, Domestic conference
    Oral presentation

  • Cannot ventilate, cannot intubate situation after penetration of the tongue root through to the epipharynx by a surfboard: a case report
    Ono Y, Y Ikegami, J Shimada, A Hasegawa, Y Tsukada, Y Abe, C Tase
    The 14th Annual Meeting of Japanese Society for Emergency Medicine, Jun. 2011, Japanese, Japanese Society for Emergency Medicine, Sapporo, Japan., Domestic conference
    Oral presentation

  • Disseminated intravascular coagulation with kidney and liver dysfunction after ingestion of a naphazoline-containing antiseptic
    Ono Y, Y Ikegami, Y Tsukada, J Shimada, A Hasegwa, Y Abe, T Suzuki, C Tase
    The 38th Annual Meeting of The Japanese Society of Intensive Care Medicine, Feb. 2011, Japanese, The Japanese Society of Intensive Care Medicine, Yokohama, Japan., Domestic conference
    Poster presentation

  • 重篤な高カリウム血症に陥ったグリホサート中毒の1例
    金内洋一, 大野雄康, 池上之浩, 塚田泰彦, 島田二郎, 長谷川有史, 阿部良伸, 鈴木剛, 田勢長一郎
    第25回日本中毒学会東日本地方会, Jan. 2011, Japanese, 札幌市, Domestic conference
    Oral presentation

  • ナファゾリン含有殺菌消毒剤服用により急性肝腎障害に播種性血管内凝固症候群を合併した一例
    大野雄康, 池上之浩, 塚田泰彦, 島田二郎, 長谷川有史, 阿部良伸, 鈴木剛, 田勢長一郎
    第25回日本中毒学会東日本地方会, Jan. 2011, Japanese, 日本中毒学会, 札幌市, Domestic conference
    Oral presentation

  • 小脳失調を来たした重症熱中症の1例
    阿部良伸, 島田二郎, 池上之浩, 長谷川有史, 塚田泰彦, 大野雄康, 中村裕一, 鈴木剛, 田勢長一郎
    第38回日本救急医学会総会, Oct. 2010, Japanese, 東京都, Domestic conference
    Others

  • Scrub typhus complicated by severe disseminated intravascular coagulation: An autopsy case report
    Ono Y, Y Ikegami, Y Abe, A Hasegawa, Y Tsukada, J Shimada, C Tase
    The 38th Annual Meeting of Japanese Association for Acute Medicine, Oct. 2010, Japanese, Japanese Association for Acute Medicine, Tokyo, Japan., Domestic conference
    Oral presentation

  • G群溶血性連鎖球菌による劇症型連鎖球菌感染症の一例
    長谷川有史, 池上之浩, 鈴木剛, 大野雄康, 阿部良伸, 塚田泰彦, 田勢長一郎
    第38回日本救急医学会総会, Sep. 2010, Japanese, 東京都, Domestic conference
    Others

  • Bilateral external carotid artery ligation in patient with severe facial injury: A case report
    Ono Y, Y Ikegami, J Shimada, Y Tsukada, Y Abe, T Suzuki, C Tase
    The 19th Annual Meeting of The Japanese Society of Intensive Care Medicine, Tohoku Branch., Jul. 2010, Japanese, The Japanese Society of Intensive Care Medicine, Tohoku Branch., Sendai, Japan., Domestic conference
    Oral presentation

  • ドクターヘリが奏効し出血性ショックから離脱、救命した外傷性腸管損傷・腸管脱出の一例
    鈴木剛, 長谷川有史, 大野雄康, 阿部良伸, 塚田泰彦, 島田二郎, 池上之浩, 田勢長一郎
    第24回東北救急医学会学術集会, Jun. 2010, Japanese, 秋田県, Domestic conference
    Oral presentation

  • G群溶血性連鎖球菌による劇症型連鎖球菌感染症の一例
    長谷川有史, 鈴木剛, 大野雄康, 塚田泰彦, 島田二郎, 池上之浩, 田勢長一郎
    第24回東北救急医学会学術集会, Jun. 2010, Japanese, 秋田県, Domestic conference
    Oral presentation

  • 遠隔地域における心停止症例に対しドクターヘリの効果はあるか
    田勢長一郎, 大野雄康
    第13回日本臨床救急医学会学術集会, Jun. 2010, Japanese, 千葉, 日本, Domestic conference
    Oral presentation

  • ドクターヘリ及びその後の早急な治療により救命できた急性心筋梗塞の1例
    大野雄康, 塚田泰彦, 長谷川有史, 池上之浩, 田勢長一郎
    第12回日本臨床救急医学会, Jun. 2009, Japanese, 日本臨床救急医学会, 大阪、日本, Domestic conference
    Oral presentation

  • Bilateral psoas abscess after pyogenic spondylitis: Two cases reports
    Ono Y, A Hasegawa, Y Tsukada, J Shimada, Y Ikegami
    The 18th Annual Meeting of The Japanese Society of Intensive Care Medicine, Tohoku Branch, Apr. 2009, Japanese, The Japanese Society of Intensive Care Medicine, Tohoku Branch, Koriyama, Japan., Domestic conference
    Oral presentation

  • ドクターヘリの搬送先病院の検討
    田勢長一郎, 長谷川有史, 塚田泰彦, 島田二郎, 池上之浩, 大野雄康
    第3回病院前救急診療研究会学術集会, Dec. 2008, Japanese, 東京都, Domestic conference
    Oral presentation

  • 福島県における救急患者受入れ困難状況.
    大野雄康, 長谷川有史, 塚田泰彦, 島田二郎, 池上之浩, 田勢長一郎
    第3回病院前救急診療研究会, Dec. 2008, Japanese, 東京, Domestic conference
    Oral presentation

  • Traumatic vertebral artery occulusion: A case report
    Ono Y, Y Ikegami, Y Abe, M Abe, Y Tsukada, A Hasegawa, J Shimada, C Tase, H Tachihara
    The 22nd Annual Meeting of Japanese Association for Acute Medicine, Tohoku Branch, Jun. 2008, Japanese, Japanese Association for Acute Medicine, Tohoku Branch, Koriyama, Japan, Domestic conference
    Oral presentation

■ Affiliated Academic Society
  • Japan Endotoxin and Innate Immunity Society
    Oct. 2021 - Present

  • Japan Society for Critical Care Medicine (No. CCM0476)
    Sep. 2019 - Present

  • The Japan Shock Society (No. 1748)
    Dec. 2018 - Present

  • Japanese Association for Medical Simulation (No. JAMS-0829)
    Feb. 2015 - Present

  • Japanese Society of Intensive Care Medicine (No. 5431)
    May 2009 - Present

  • Japanese Society of Anesthesiologists (No. 00015541)
    May 2009 - Present

  • Japanese Association for Acute Medicine (No. o1702)
    Oct. 2008 - Present

■ Research Themes
  • Yuko Ono
    Japan society for the promotion of science, JSPS KAKENHI, JSPS KAKENHI Grant Number 25K12250, Kobe university, Apr. 2025 - Mar. 2028, Principal investigator

  • Elucidation of the pathophysiology of skeletal muscle atrophy in aged patients with sepsis and myokine for the novel therapeutic target of post intensive care syndrome (PICS)
    Shigeaki Inoue, Yuko Ono, Nobuto Nakanishi, Kyohei Miyamoto
    Japan society for the promotion of science, JSPS KAKENHI, JSPS KAKENHI Grant Number 24K12198, Wakayama Medical University, Apr. 2024 - Mar. 2027, Coinvestigator

  • Jun Sugiyama, Joji Kotani, Yuko Ono, Nobuto Nakanishi, Kazushi Takayama
    Foundation for Ambulance Service Development, Tokyo, Japan, Grant for emergency medicine in 2025., Kobe university, Apr. 2025 - Mar. 2026, Coinvestigator
    Competitive research funding

  • Yuko Ono
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2022 - Mar. 2025, Principal investigator

  • The excellent young investigator award (2023) associated grant
    Kobe university, Kobe University The excellent young investigator award (2023) associated grant, Kobe university, Jun. 2023 - Jun. 2024, Principal investigator

  • Gender disparities in first authorship at three medical universities in an area affected by the Great East Japan Earthquake
    Yuko Ono, Yudai Iwasaki, Joji Kotani
    Research Center for Urban Safety and Security Kobe University, Academic collaboration grant between Tohoku University and Kobe University for earthquake disaster reconstruction and disaster science, Apr. 2022 - Apr. 2023, Principal investigator
    Competitive research funding

  • Toll like receptor/Nuclear Factor-kappa B signaling pathway inhibition for burn-induced skeletal muscle atrophy
    Yuko Ono, Shigeaki Inoue, Masafumi Saito, Joji Kotani
    Public Trust Foundation of Marumo ER medicine & Research Institute, Oct. 2021 - Oct. 2022, Principal investigator
    Competitive research funding

  • Yuko Ono
    Japan society for the promotion of science, SPS KAKENHI Grant Number 18K16544, Grant-in-Aid for Early-Career Scientists, Apr. 2018 - Mar. 2022, Principal investigator
    The main purposes of this project are to find novel pharmacological intervention to prevent sepsis induced skeletal muscle atrophy. To achieve this goal, we have established in vitro and in vivo models of sepsis induced skeletal muscle atrophy. Using these models, we seek to determine whether pharmacological inhibition of TLR4/NF-κB signal (1) prevents skeletal muscle degradation; (2) histologically ameliorates skeletal muscle atrophy; and (3) functionally improve skeletal muscle contraction.
    Competitive research funding

  • Drug Exploration for Sepsis-Induced Skeletal Muscle Atrophy
    Yuko Ono, Kenju Shimomura, Yuko Maejima
    Japanese Society of Anesthesiologists, The 66th Annual Meeting of the Japanese Society of Anesthesiologists, The pitch contest Grant Number A18-3, Jul. 2018 - Jun. 2019, Principal investigator
    Competitive research funding

  • Yuko Ono
    Japan society for the promotion of science, JSPS KAKENHI Grant Number 15K20349, Apr. 2015 - Mar. 2018, Principal investigator
    We found lipopolysaccharide inhibit muscle differentiation on mouse myoblast (C2C12). The main object of this project are to determine this molecular mechanism in C2C12 differentiation, and find the useful drug.
    Competitive research funding

■ Social Contribution Activities
  • The 1st Kobe city medical control physician workshop 2025, lecturer. 2 hours workshop. Glucose administration in patients with hypoglycemia and crystalloid administration in patients with shock. Physician. Kobe, Japan.
    Kobe city medical control council.
    Lecturer, 27 May 2025 - 27 May 2025

  • The 57th The Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar
    Kobe university hospital
    Demonstrator, 08 May 2025 - 08 May 2025

  • The 1st Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3 hours 2025
    Hanshin-Tamba region medical control post-enumeration committee
    16 Apr. 2025 - 16 Apr. 2025

  • The 114th Kobe city medical control post-enumeration committee. Kobe, Japan. 3hours
    Kobe city medical control council.
    Organizing member, 07 Mar. 2025 - 07 Mar. 2025

  • The 3rd Kobe city medical control physician workshop 2024, lecturer. 2 hours workshop. Glucose administration in patients with hypoglycemia and crystalloid administration in patients with shock. Physician. Kobe, Japan.
    Kobe city medical control council
    Lecturer, 03 Mar. 2025 - 03 Mar. 2025

  • The 150 th difficult airway management (DAM) practical seminar, Instructor, Japanese Association for Medical Simulation, Tohoku University, Sendai, Miyagi, Japan. Physicians and Nurses; 8 hours course
    Lecturer, 01 Mar. 2025 - 01 Mar. 2025

  • The 6th Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 1.5 hours
    Hanshin-Tamba region medical control post-enumeration committee
    Advisor, 19 Feb. 2025 - 19 Feb. 2025

  • The 2nd emergency medical technician training committee 2024, Kobe city medical control council. 2 hours Kobe city municipal office
    Kobe city medical control council.
    21 Jan. 2025 - 21 Jan. 2025

  • The 5th Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    Advisor, 18 Dec. 2024 - 18 Dec. 2024

  • The Hanshin-Tamba region medical control physician workshop, lecturer. 1 hours Burn and electrical Injuries. Physician and emergency lifesaving technicians. Kobe, Japan.
    Hanshin-Tamba region medical control post-enumeration committee
    Lecturer, 30 Oct. 2024 - 30 Oct. 2024, General

  • The 4th Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    16 Oct. 2024 - 16 Oct. 2024

  • The Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar
    Kobe university hospital
    03 Oct. 2024 - 03 Oct. 2024

  • The 2nd Kobe city medical control physician workshop 2024, lecturer. 2 hours workshop. Glucose administration in patients with hypoglycemia and crystalloid administration in patients with shock. Physician. Kobe, Japan.
    Kobe city medical control council.
    Lecturer, 24 Sep. 2024 - 24 Sep. 2024, General

  • The 112th Kobe city medical control post-enumeration committee. Kobe, Japan. 3hours
    Kobe city medical control council.
    06 Sep. 2024 - 06 Sep. 2024

  • The 55th The Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar
    Kobe university hospital
    05 Sep. 2024 - 05 Sep. 2024

  • The 3rd Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    21 Aug. 2024 - 21 Aug. 2024

  • The 54th Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar, August 1, 2024
    Kobe university hospital
    Lecturer, 01 Aug. 2024 - 01 Aug. 2024

  • The 1st emergency medical technician training committee 2024, Kobe city medical control council. 2 hours Kobe city municipal office. July 19, 2024
    Kobe city medical control council
    Organizing member, 19 Jul. 2024 - 19 Jul. 2024

  • The 2nd Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    Organizing member, 19 Jun. 2024 - 19 Jun. 2024

  • The 51th Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar
    Kobe university hospital
    Lecturer, 06 Jun. 2024 - 06 Jun. 2024

  • The 1st Kobe city medical control physician workshop 2024, lecturer. 2 hours workshop. Glucose administration in patients with hypoglycemia and crystalloid administration in patients with shock. Physician. Kobe, Japan.
    Kobe city medical control council.
    Organizing member, 04 Jun. 2024 - 04 Jun. 2024

  • The 1st Hanshin-Tamba region medical control post-enumeration committee 2024. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    Organizing member, 17 Apr. 2024 - 17 Apr. 2024

  • The 6th Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3 hours
    Hanshin-Tamba region medical control post-enumeration committee
    Organizing member, 21 Feb. 2024 - 21 Feb. 2024

  • January 26, 2024 The 2nd emergency medical technician training committee, Kobe city medical control council. 2 hours
    Kobe city medical control council
    Organizing member, 26 Jan. 2024 - 26 Jan. 2024

  • The 5th Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3hours
    Hanshin-Tamba region medical control post-enumeration committee
    20 Dec. 2023 - 20 Dec. 2023

  • The 4th Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3hours
    Hanshin-Tamba region medical control post-enumeration committee
    18 Oct. 2023 - 18 Oct. 2023

  • The 48th Central venous catheter (CVC) placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Junior residents. 1.5 hours seminar
    Kobe university hospital, Kobe, Japan.
    03 Aug. 2023 - 03 Aug. 2023

  • The 3rd Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3hours
    The 3rd Hanshin-Tamba region medical control post-enumeration committee.
    Aug. 2023 - Aug. 2023

  • Tamba city fire department headquarters, The emergency case conference. 1 hour
    Tamba city fire department headquarters
    28 Jul. 2023 - 28 Jul. 2023

  • The 1st emergency medical technician training committee, Kobe city medical control council. 2 hours
    Kobe city medical control council.
    12 Jul. 2023 - 12 Jul. 2023

  • The 2nd Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3hours
    Advisor, 21 Jun. 2023 - 21 Jun. 2023

  • Central venous catheter placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Residents. 1.5 hours seminar
    Kobe university hospital, May 25, 2023.
    25 May 2023 - 25 May 2023

  • The 1st Hanshin-Tamba region medical control post-enumeration committee. Tamba, Japan. 3hours
    Hanshin-Tamba region medical control post-enumeration committee
    19 Apr. 2023 - 19 Apr. 2023

  • Kobe city medical control post-enumeration committee. Kobe, Japan.
    Advisor, 07 Nov. 2022 - 07 Nov. 2022

  • The 39th Central venous catheter placement hands on seminar, facilitator. Kobe university hospital, Kobe, Japan. Physicians and residents. 1.5 hours seminar
    Kobe university hospital
    16 Jun. 2022 - 16 Jun. 2022, Others

  • The 119th difficult airway management (DAM) practical seminar, Instructor.
    Japanese Association for Medical Simulation
    09 Mar. 2019 - 09 Mar. 2019

  • The 100th difficult airway management (DAM) practical seminar
    Japanese Association for Medical Simulation
    Lecturer, Mar. 2017, Tohoku University, Sendai, Miyagi, Japan., Others, Lecturer

  • The 99th difficult airway management (DAM) practical seminar, Instructor.
    Japanese Association for Medical Simulation
    Lecturer, The 99th difficult airway management (DAM) practical seminar,, Feb. 2017, Fukushima Medial University, Fukushima, Japan., Others, Instructor.

  • The 87th difficult airway management (DAM) practical seminar
    Lecturer, Mar. 2016, Target : Tohoku University, Sendai, Miyagi, Japan. Physicians and Nurses; 8 hours course Part : Instructor

  • The 86th difficult airway management (DAM) practical seminar
    Feb. 2016, Fukushima Medial University, Fukushima, Japan Target : Physicians and Nurses Part : Instructor

  • The 83rd Difficult Airway Management (DAM) practical seminar
    Lecturer, Oct. 2015, Iwate Medical University Target : Japanese Association for Medical Simulation Part : instructor

■ Media Coverage
  • CareNet, 論文/ニュース/連載/コラム, Apr. 2025, https://www.carenet.com/news/general/hdnj/60339, 人はそれぞれ、価格、燃費、デザイン、安全性などを基準に車を選ぶが、軽自動車は普通車と比べ、交通事故後の院内死亡率が上昇するという研究結果が報告された。また軽自動車では、頭頸部、胸部、腹部、骨盤および四肢に重度の外傷、重傷を負うリスクが高かったという。神戸大学大学院医学研究科外科系講座災害・救急医学分野の大野雄康氏らによるこの研究結果は、「PLOS One」に2月5日掲載された。 軽自動車は「ミニカー」とも呼ばれ、日本だけでなく海外での人気も高まっている。人気の理由の1つとして、車体のコンパクトさが挙げられるが、それは車内空間が狭まることも意味する。車内空間が狭くなると、衝突時の衝撃による変形に対して乗員がダイレクトに危険に晒されることになる。しかしながら、車内空間の狭さが生存率の低下や、重度の外傷にあたえる影響については十分に検証されてこなかった。こうした背景から、大野氏らは過去に自動車事故で負傷・入院した患者を対象とした単施設の後ろ向きコホート研究を行った。主要評価項目は事故後の院内死亡率とした。 本研究の対象患者は、2002年1月1日~2023年12月31日の間に、太田西ノ内病院(福島県郡山市)にて受け入れた交通事故で負傷したすべての車両乗員とした。普通車と軽自動車以外の車両(自転車、オートバイ、大型トラックなど)に乗っていた外傷患者は除外し、5,331名(普通車群2,947名、軽自動車群2,384名)を対象に含めた。最終的に1対1の傾向スコア(PS)マッチングを行い、1,947組を解析対象とした。 PSマッチングを行い、事故後の院内死亡率を比較した結果、軽自動車群で院内死亡率の上昇が認められた(2.6 vs 4.0%、p=0.019)。院内死亡のリスクについても軽自動車群で上昇していた(オッズ比1.53〔95%信頼区間1.07~2.19〕)。また、軽自動車群の院内死亡率の上昇は、シートベルトをしていた患者、運転席にいた患者、エアバッグが展開した事故に巻き込まれた患者のサブグループで特に顕著だった。 次に車両の種類と、特異的な外傷の部位の関連について解析を行った。PSマッチング後、軽自動車群で、外傷重症度スコア(ISS)>15で定義される重症外傷を負うリスクが高くなり、部位別では頭頸部、胸部、腹部および骨盤内臓器、四肢および骨盤に重症外傷を負うリスクが高まっていた。この傾向は、シートベルトをしていた患者、エアバッグの展開した患者のサブグループで特に顕著だった。 生理学的重症度については、軽自動車群で昏睡、ショック(収縮期血圧90mmHg未満に低下)のリスク増加が認められた。また、救急のための気管内挿管、緊急手術を必要とした患者の割合も軽自動車群で有意に増加することが示された(各p=0.046、p=0.001)。 研究グループは、本研究について、「軽自動車の乗員は、有害な転帰のリスクが高く、緊急の外科的介入や追加の医療資源が必要になる可能性がある。シートベルトを着用していた患者、エアバッグの展開した患者で、院内死亡率と部位特異的な外傷が増加していたが、この結果は、軽自動車の乗員に対してより安全な拘束システムの必要性を示唆している。今回の研究データは、購入する側とメーカーの両者に、車両の安全性に関する客観的事実を考えてもらうために利用されるべきだ」と総括した。 また、本研究の限界点については、単一施設での観察研究であり結果の一般化には限界があること、搬送患者は重症患者に偏っていた可能性があることなどを挙げている。
    Internet

  • K-cars vehicles and standard vehicles: Which is safer?
    BUZZREACH, smt, Mar. 2025, https://www.searchmytrial.com/which-safe-regular-car-minicar/
    Internet

  • "Are accidents involving K-cars vehicles more dangerous than standard vehicles? Research findings that go beyond just saying 'as expected.'"
    DIAMOND online, DIAMOND online, Mar. 2025, https://diamond.jp/articles/-/361234
    Internet

  • The resarch article written by Yuko Ono has been published in PLOS one (2025)
    Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Mar. 2025, https://www.med.kobe-u.ac.jp/ems/information/news/plos-one.html
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Kobe University, Jul. 2024, https://www.med.kobe-u.ac.jp/ems/information/news/-30.html
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Kobe University, Jul. 2024, https://www.med.kobe-u.ac.jp/ems/information/news/-case-imageacute-med-surg.html
    Internet

  • Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Apr. 2024
    Internet

  • Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Apr. 2024
    Internet

  • Kobe University, Kobe University, Dec. 2023, 10月12日及び12月14日に令和4年度優秀若手研究者賞授賞式及び研究発表会を本部棟6F大会議室にて行いました。 「優秀若手研究者賞」は、本学が卓越研究大学として世界最高水準の教育研究拠点になるための取組みの一環として、平成27年度に創設されたものです。卓越した業績を上げた若手研究者を表彰し、将来本学の研究リーダーとして活躍することを期待すると共に、研究者の育成及びその能力を最大限に発揮できるシステムを構築することを目的としています。 各学系長から推薦を受けた若手研究者の中から、論文・著書の成果、受賞歴、外部資金獲得状況や社会貢献といった業績を評価した結果、7名の受賞者が選ばれ、藤澤学長より表彰されました。また、受賞者には研究費が併せて授与されました。 授賞式及び研究発表会には学長、理事、部局長等が出席し、受賞者は自身の研究内容についてプレゼンテーションを行い、出席者からの質問に答えるなどしました。 神戸大学では、これからも優秀な若手研究者を様々な形で積極的に支援していく予定です。 優秀若手研究者賞 ● 人文学研究科 柳澤 邦昭 准教授 研究発表タイトル:社会的孤立の科学 ● 経営学研究科 中村 絵理 准教授 研究発表タイトル:我が国下水道事業の包括的民間委託契約に関する実証分析 ● 農学研究科 木田 森丸 助教 研究発表タイトル:天然有機物の「運命」の決定要因 ● 内海域環境教育研究センター 堀江 好文 准教授 研究発表タイトル:水圏環境汚染物質が水生生物に与える影響評価 ● 医学部附属病院 大野 雄康 助教 研究発表タイトル:生体侵襲と骨格筋タンパク質の異化と同化および骨格筋新生 ● 医学部附属病院 堀之内 智子 助教 研究発表タイトル:⼩児腎疾患における分⼦遺伝学的研究 ● 保健学研究科 龍野 洋慶 講師 研究発表タイトル:これまでの研究概要 今後の本学での研究の展望
    Internet


  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Oct. 2023
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Sep. 2023
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Sep. 2023
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Sep. 2023
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jul. 2023, https://www.med.kobe-u.ac.jp/ems/information/news/-29.html
    Internet

  • Kobe University, Kobe University, Jun. 2023, https://www.kobe-u.ac.jp/NEWS/info/2023_06_16_01.html, 神戸大学では、卓越した業績を挙げた若手研究者が、将来本学の研究リーダーとして活躍することを期待し、また若手研究者らの活性化を図るため、その研究結果・積み重ねに対して表彰を行う「優秀若手研究者賞」を毎年度実施しており、このたび令和5年度の受賞者が決定しました。 なお、授賞式及び研究発表会の実施を年内に予定しています。 受賞者一覧 人文学研究科 柳澤邦昭 准教授 経営学研究科 中村絵理 准教授 農学研究科 木田森丸 助教 内海域環境教育研究センター 堀江好文 准教授 医学部附属病院 大野雄康 助教 医学部附属病院 堀之内智子 助教 保健学研究科 龍野洋慶 講師
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jun. 2023, https://www.med.kobe-u.ac.jp/ems/information/news/-70.html
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Apr. 2023
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Feb. 2023, https://www.med.kobe-u.ac.jp/ems/information/news/-icuccu.html
    Internet

  • Myself, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Dec. 2022
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Sep. 2022
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Aug. 2022
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Nov. 2021
    Internet


  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jul. 2021
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jun. 2021
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jun. 2021
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Mar. 2021
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jul. 2020
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, May 2020
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Feb. 2020
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, Jan. 2020
    Internet

  • HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, HP: Department of Disaster and Emergency Medicine, Graduate School of Medicine, Kobe University, May 2019
    Internet

  • Fukushima Medical University, Fukushima Medical University, Jul. 2017
    Internet

■ Academic Contribution Activities
■ Others
  • Japanese Society of Anesthesiologists, Board certified supervisory anesthesiologist No.10455
    Apr. 2023 - Present

  • Japanese Association for Acute Medicine Board certified supervisory emergency physician. No.1112
    Jan. 2023 - Present

  • On-The-Ground Special Radio Operator (3rd grade) EBSO02977, Kinki Bureau of Telecommunications
    Mar. 2020 - Present

  • Japan Diaster Medical Assistance Team (DMAT) No. 13527
    Nov. 2018 - Present, Ministry of Health, Labour and Welfare, No. 13527

  • Preclinical Objective Structured Clinical Examination (OSCE), certified examiner No. 18-02-08-0323
    Jan. 2018 - Present, Common Achievement Tests Organization, (No. 18-02-08-0323)

  • Japanese Society of Anesthesiologists Board certification No.10455
    Apr. 2016 - Present, Japanese Society of Anesthesiologists Board certification No.10455

  • Japanese Association for Medical Simulation, Difficult Airway Management (DAM) practical seminar certified instructor (DAM0093)
    Jun. 2015 - Present

  • Certified Clinical mentor, No. H26_21
    Dec. 2014 - Present, Ministry of Health, Labour and Welfare. No. H26_21,

  • Japanese Association for Acute Medicine Board certification No.4767
    Jan. 2013 - Present, Japanese Association for Acute Medicine Board certification, No.4767

  • Japanese Society of Anesthesiologists Qualified Anesthesiologist No.10455
    Jan. 2013 - Present, No.10455, Japanese Society of Anesthesiologists

  • Japanese Ministry of Health, Labour and Welfare Qualified Anesthesiologist No. 26656
    Dec. 2012 - Present, No. 26656, Japanese Ministry of Health, Labour and Welfare

  • Health-insurance medical practitioner, No. 59039, Kinki Regional Bureau of Health and Welfare
    May 2007 - Present

  • Jpanese Medical License No. 463176
    Apr. 2007 - Present, No. 463176, Ministry of Health, Labour and Welfare

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