Research activity information

• Jun. 2019 20th EFORT Annual Congress Lisbon 2019, Best Poster Award (Jacques Duparc Awards), Endochondral Bone Regeneration Using Chondrogenically Differentiated Human Induced Pluripotent Stem Cells.

  Lee SY, Arakura M, Fukui T, Kuroda R, Niikura T


• Jun. 2019 20th EFORT Annual Congress Lisbon 2019, Best Poster Presentation Award, Soluble fibrin monomer complex can be a useful predictor of venous thromboembolism after fracture surgery.

  Fukui T, Lee SY, Iwakura T, Kuroda R, Niikura T


• May 2019 The 4th AOTrauma Asia Pacific Scientific Congress, Young Investigator Award, Effect of Transcutaneous Application of CO2 on Bone Regeneration in Distraction Osteogenesis

  Kumabe Y, Niikura T, Oe K, Fukui T, Takahara S, Kuroiwa Y, Oda T, Sawauchi K, Kuroda R


• Nov. 2018 The 16th International Society for Fracture Repair, Best Case Report Award, Infectious open-knee joint fracture with soft tissue defect treated with antimicrobial megaprosthesis supported with iodine: a case report

  Sawauchi K, Fukui T, Oe K, Kuroiwa Y, Kumabe Y, Oda T, Tsuchiya H, Kuroda R, Niikura T


• Nov. 2018 The 16th International Society for Fracture Repair, Best Presentation Award (Clinical study), Topical cutaneous application of carbon dioxide using ahydrogel is anovel treatment option to assist fracture repair -Results of a clinical trial-

  Niikura T, Iwakura T, Lee SY, Oe K, Fukui T, Sakai Y, Akisue T, Kuroda R


• Jul. 2017 第43回日本骨折治療学会, 学会賞, 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる -臨床試験の報告-

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 黒田 良祐


• May 2013 The 14th European Congress of Trauma and Emergency Surgery., Best Oral Presentation Award, Local Transplantation of G-CSF-Mobilized CD34+ Cells for Patients with Femoral and Tibial Nonunion: Phase 1/2 Clinical Trial.

  Niikura T, Kuroda R, Matsumoto T, Lee SY, Mifune Y, Fukui T, Kawakami Y, Kurosaka M


• Oct. 2010 The 7th Combined meeting of Orthopaedic Research Societies, New Investigator Recognition Award, Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cell Transplantation for Nonunion of Bone Fractures

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto A, Kuroda T, Niikura T, Miwa M, Kuroda R, Kurosaka M, Asahara T


• Mar. 2010 The 56th Orthopaedic Research Society, New Investigator Research Award Finalist, The New Strategy for Fracture Healing of Pseudoarthrosis by Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cells

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto A, Kuroda T, Niikura T, Miwa M, Kuroda R, Kurosaka M, Asahara T


• Mar. 2010 第9回日本再生医療学会総会, ベストポスター賞, ゼラチンハイドロゲルに包含した 低用量シンバスタチン局所投与による骨折治療

  福井 友章, 伊井 正明, 美舩 泰, 庄司 太郎, 松本 知之, 川上 洋平, 黒田 知也, 川本 篤彦, 斎藤 高志, 城 潤一郎, 田畑 泰彦, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

• Transcutaneous CO2 application combined with low-intensity pulsed ultrasound accelerates bone fracture healing in rats.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Shota Inoue, Ryota Nishida, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Low-intensity pulsed ultrasound (LIPUS) is a non-invasive therapy that accelerates fracture healing. As a new treatment method for fracture, we recently reported that the transcutaneous application of CO2 accelerated fracture healing in association with promoting angiogenesis, blood flow, and endochondral ossification. We hypothesized that transcutaneous CO2 application, combined with LIPUS, would promote bone fracture healing more than the single treatment with either of them. METHODS: Femoral shaft fractures were produced in 12-week-old rats. Animals were randomly divided into four groups: the combination of CO2 and LIPUS, CO2, LIPUS, and control groups. As the transcutaneous CO2 application, the limb was sealed in a CO2-filled bag after applying hydrogel that promotes CO2 absorption. Transcutaneous CO2 application and LIPUS irradiation were performed for 20 min/day, 5 days/week. At weeks 1, 2, 3, and 4 after the fractures, we assessed the fracture healing process using radiography, histology, immunohistochemistry, real-time PCR, and biomechanical assessment. RESULTS: The fracture healing score using radiographs in the combination group was significantly higher than that in the control group at all time points and those in both the LIPUS and CO2 groups at weeks 1, 2, and 4. The degree of bone fracture healing in the histological assessment was significantly higher in the combination group than that in the control group at weeks 2, 3, and 4. In the immunohistochemical assessment, the vascular densities of CD31- and endomucin-positive microvessels in the combination group were significantly higher than those in the control and LIPUS groups at week 2. In the gene expression assessment, significant upregulation of runt-related transcription factor 2 (Runx2) and vascular endothelial growth factor (VEGF) was detected in the combination group compared to the LIPUS and CO2 monotherapy groups. In the biomechanical assessment, the ultimate stress was significantly higher in the combination group than in the LIPUS and CO2 groups. CONCLUSION: The combination therapy of transcutaneous CO2 application and LIPUS had a superior effect in promoting fracture healing through the promotion of angiogenesis and osteoblast differentiation compared to monotherapy.

  Oct. 2024, BMC musculoskeletal disorders, 25(1) (1), 863 - 863, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 人工股関節ステム周囲骨折後偽関節の治療経験

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 88 - 88, Japanese


• 膝関節が露出した膝蓋骨骨折術後感染をCLAPと腓腹筋弁によりサルベージした一例

  藤原 悠, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2024, 中部日本整形外科災害外科学会雑誌, 67(春季学会) (春季学会), 143 - 143, Japanese


• 【骨折治療の現在地を知る!】感染・偽関節 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療について

  大江 啓介, 新倉 隆宏, 福井 友章, 隈部 洋平, 松本 知之, 黒田 良祐

  金原出版(株), Apr. 2024, 整形・災害外科, 67(5) (5), 681 - 687, Japanese


• 非定型大腿骨骨折において骨転移に対する骨修飾薬使用歴の有無が治療経過に与える影響

  福井 友章, 大江 啓介, 隈部 洋平, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S142 - S142, Japanese


• CLAPにおけるゲンタマイシンの薬物動態に関する検討

  松宮 豊, 大江 啓介, 福井 友章, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(2) (2), S426 - S426, Japanese


• AMED事業で進む運動器再生医療-臨床研究と医師主導治験- 多施設医師主導治験「自家末梢血CD34陽性細胞移植による骨・血管再生」

  黒田 良祐, 松本 知之, 大江 啓介, 福井 友章, 美舩 泰, 新倉 隆宏

  (公社)日本整形外科学会, Mar. 2024, 日本整形外科学会雑誌, 98(3) (3), S1186 - S1186, Japanese


• Effects of high antibiotic concentrations applied to continuous local antibiotic perfusion on human bone tissue-derived cells.

  Yuya Yamamoto, Tomoaki Fukui, Kenichi Sawauchi, Ryo Yoshikawa, Kyohei Takase, Yohei Kumabe, Akihiro Maruo, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe

  AIMS: Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived cells. METHODS: Cells were isolated from the bone tissue grafts collected from six patients using the Reamer-Irrigator-Aspirator system, and exposed to different gentamicin concentrations. Live cells rate, apoptosis rate, alkaline phosphatase (ALP) activity, expression of osteoblast-related genes, mineralization potential, and restoration of cell viability and ALP activity were examined by in vitro studies. RESULTS: The live cells rate (the ratio of total number of cells in the well plate to the absorbance-measured number of live cells) was significantly decreased at ≥ 500 μg/ml of gentamicin on day 14; apoptosis rate was significantly increased at ≥ 750 μg/ml, and ALP activity was significantly decreased at ≥ 750 μg/ml. Real-time reverse transcription-polymerase chain reaction results showed no significant decrease in the ALP and activating transcription factor 4 transcript levels at ≥ 1,000 μg/ml on day 7. Mineralization potential was significantly decreased at all concentrations. Restoration of cell viability was significantly decreased at 750 and 1,000 μg/ml on day 21 and at 500 μg/ml on day 28, and ALP activity was significantly decreased at 500 μg/ml on day 28. CONCLUSION: Our findings suggest that the exposure concentration and duration of antibiotic administration during CLAP could affect cell functions. However, further in vivo studies are needed to determine the optimal dose in a clinical setting.

  Mar. 2024, Bone & joint research, 13(3) (3), 91 - 100, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 【偽関節治療のエキスパートを目指そう】偽関節に対する新しい治療法 CD34陽性細胞移植とBMP(bone morphogenetic protein)

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese


• Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair.

  Ryosuke Kuroda, Takahiro Niikura, Tomoyuki Matsumoto, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Yoshiharu Miyata, Shinichiro Kawamoto, Tatsuo Kagimura, Yasuyuki Fujita, Atsuhiko Kawamoto

  BACKGROUND: We previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we also demonstrated the safety and efficacy of this cell therapy in an earlier phase I/II clinical trial conducted on seven patients with fracture nonunion. Herein, we present the results of a phase III clinical trial conducted to confirm the results of the previous phase studies using a larger cohort of patients. METHODS: CD34 + cells were mobilized via administration of granulocyte colony-stimulating factor, harvested using leukapheresis, and isolated using magnetic cell sorting. Autologous CD34 + cells were transplanted in 15 patients with tibia nonunion and 10 patients with femur nonunion, who were followed up for 52 weeks post transplantation. The main outcome was a reduction in time to heal the tibia in nonunion patients compared with that in historical control patients. We calculated the required number of patients as 15 based on the results of the phase I/II study. An independent data monitoring committee performed the radiographic assessments. Adverse events and medical device failures were recorded. RESULTS: All fractures healed during the study period. The time to radiological fracture healing was 2.8 times shorter in patients with CD34 + cell transplantation than in the historical control group (hazard ratio: 2.81 and 95% confidence interval 1.16-6.85); moreover, no safety concerns were observed. CONCLUSIONS: Our findings strongly suggest that autologous CD34 + cell transplantation is a novel treatment option for fracture nonunion. TRIAL REGISTRATION: UMIN-CTR, UMIN000022814. Registered on 22 June 2016.

  Oct. 2023, BMC medicine, 21(1) (1), 386 - 386, English, International magazine

  Scientific journal


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 250 - 250, Japanese


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  藤田 大樹, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 312 - 312, Japanese


• 特徴的画像所見を示した脛骨慢性骨髄炎の一例

  古川 太河, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2023, 中部日本整形外科災害外科学会雑誌, 66(秋季学会) (秋季学会), 314 - 314, Japanese


• 3D造形βTCP人工骨の生体活性の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1718 - S1718, Japanese


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1723 - S1723, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1747 - S1747, Japanese


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田 亮太, 大江 啓介, 福井 友章, 澤内 健一, 山本 裕也, 高瀬 恭平, 吉川 遼, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1749 - S1749, Japanese


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 120 - 120, Japanese


• CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係

  松宮 豊, 大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 121 - 121, Japanese


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 131 - 131, Japanese


• Multicenter study on atypical femoral fractures in patients with bone metastases taking bone- modifying agents.

  Tomoaki Fukui, Keisuke Oe, Teruya Kawamoto, Masayuki Morishita, Ikuo Fujita, Shunsuke Takahara, Atsushi Sakurai, Takashi Iwakura, Keiji Yoshida, Kenjiro Ito, Etsuo Shoda, Takafumi Hiranaka, Masaya Tsunoda, Ryosuke Kuroda, Takahiro Niikura

  Bone-modifying agents (BMAs), with bone-resorptive inhibitory effects, such as zoledronic acid and denosumab, are widely used at higher doses for bone-related events caused by bone metastasis of malignant tumors. These drugs have been suggested to be associated with atypical femoral fractures (AFFs), and the relationship between BMAs and AFFs has attracted attention. To investigate the clinical features including bone union time of AFFs in patients administered BMA for bone metastasis, we conducted a retrospective multicenter study. Thirty AFFs from 19 patients were enrolled in this study. Thirteen patients had bilateral AFFs, and nineteen AFFs had prodromal symptoms. Eighteen AFFs underwent surgery after complete fracture, three failed to achieve bone union and required nonunion surgery, and 11 AFFs that achieved bone union had an average period until bone union of 16.2 months, which was much longer than that previously reported for ordinary AFFs. Seven patients discontinued the BMAs, but not due to AFFs. Stopping BMAs in patients with bone metastasis would make it difficult to secure their performance of activities of daily living, and AFF with BMA administration might require a longer time for union. Therefore, it would be important to prevent incomplete AFF from becoming complete AFF via prophylactic internal fixation.

  Jun. 2023, Journal of bone oncology, 40, 100478 - 100478, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Effect of low-intensity pulsed ultrasound on osteogenic differentiation of human induced membrane-derived cells in Masquelet technique.

  Kyohei Takase, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryo Yoshikawa, Yuya Yamamoto, Shinya Hayashi, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.

  Apr. 2023, Injury, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• LIPUSのinduced membrane由来細胞に対する骨分化・血管新生促進効果の検討

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 黒田 良祐

  (一社)日本移植学会, Apr. 2023, 移植, 57(4) (4), 357 - 357, Japanese


• Nonunion of Hoffa Fracture Successfully Treated by Total Knee Arthroplasty: A Case Report.

  Toshiki Kitamura, Tomoaki Fukui, Tomoyuki Matsumoto, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  A Hoffa fracture is a rare type of femoral fracture that is difficult to treat. Nonoperative treatments usually result in failure; hence, in most cases, surgical treatments are essential. Nonunion following Hoffa fracture appears to be relatively uncommon, and there are limited reports in the literature about this type of nonunion. These reports suggest that open reduction and rigid internal fixation is the standard treatment for this type of nonunion. This study reports the case of a 61-year-old male patient who suffered from left lateral Hoffa fracture after falling from a truck bed. At the former hospital, open reduction and internal fixation were performed with plates and screws at 8 days post-injury. Postoperatively, displacement of the lateral proximal fragment was observed, and the patient reported left knee pain. Therefore, a revision open reduction and internal fixation was performed 4 months post-surgery. However, 6 months after the revision surgery, the patient reported instability and pain in the left knee, and subsequent radiography revealed nonunion of the fracture in the lateral condyle. The patient was referred to our hospital for further treatment. Treatment by re-revision open reduction and internal fixation was deemed challenging, and so rotating hinge knee (RHK) arthroplasty was performed as a salvage treatment. At 3 years post-surgery, no significant problems were observed, and the patient could walk without any assistance. The range of motion of the left knee was 0 to 100° without extension lag, and there was no lateral instability. Standard treatment for Hoffa fracture nonunion is commonly anatomical reduction and rigid internal fixation. However, total knee arthroplasty may be a better option for the treatment of Hoffa fracture nonunion in older patients.

  Mar. 2023, Cureus, 15(3) (3), e35780, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1024 - S1024, Japanese


• ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江 啓介, 新倉 隆宏, 福井 友章, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1072 - S1072, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野 裕也, 福井 友章, 大江 啓介, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 289 - 289, Japanese


• Osteomyelitis of the Pubis Treated by Masquelet Technique in a Football Player: A Case Report.

  Hitomi Kitamura, Tomoaki Fukui, Keisuke Oe, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: Osteomyelitis pubis is a rare disease that presents with fever, pubic or hip pain, pain during hip movement, and claudication to avoid pain. It most frequently affects young athletes involved in sports that require twisting and cutting, but its exact cause is unknown and no definite treatment has been established. We report a case of pubic osteomyelitis in a young football player who was treated using the Masquelet technique and antibiotics with a good clinical course. CASE REPORTS: A 22-year-old male football player in a national-level university club team visited a nearby clinic complaining of high fever and mild pain in his bilateral hip joints. As a result of examination, we diagnosed osteomyelitis pubis and reconstructed the pubic symphysis by the Masquelet technique. In this case, the joint-like structure of the pubic symphysis was successfully reconstructed, and the patient was able to continue playing the sport. Three years and 3 months after surgery, he had no limitation of bilateral hip joint range of motion and did not display any symptoms while playing football. CONCLUSION: Masquelet technique could be a novel surgical method for managing osteomyelitis pubis, even in athletes.

  Dec. 2022, Journal of orthopaedic case reports, 12(12) (12), 39 - 42, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Influence of Metal Implants on Quantitative Evaluation of Bone Single-Photon Emission Computed Tomography/Computed Tomography.

  Keisuke Oe, Feibi Zeng, Takahiro Niikura, Tomoaki Fukui, Kenichi Sawauchi, Tomoyuki Matsumoto, Munenobu Nogami, Takamichi Murakami, Ryosuke Kuroda

  When visualizing biological activity at nonunion sites by the radioisotopes, gamma rays are more attenuated if metal implants are placed in the bone. However, the effects of various implant types and their placement on gamma ray attenuation in quantitative evaluation remain unknown. To elucidate these effects, we created a phantom that simulated the nonunion of the femur in this study. The count of gamma rays was measured by single-photon emission computed tomography/computed tomography (SPECT/CT) while considering CT-based attenuation correction (CTAC), metal implant placement, type (intramedullary nail or plate), and position. The count differed significantly with and without CTAC and with and without implants (both types) under CTAC. Significantly different counts were observed between the intramedullary nail and plate placed contralaterally to the lesion (i.e., non-lesion side). No significant difference was observed between the intramedullary nail and plate on the lesion side or between plates on the non-lesion and lesion sides. The measured standardized uptake value (SUV) was closer to the true SUV with CTAC than without. Moreover, the count was higher with implants than without. However, even with implants, it was lower than the actual count, indicating the absence of overcorrection. Implant type and position do not seem to influence the count.

  Nov. 2022, Journal of clinical medicine, 11(22) (22), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Human Non-Hypertrophic Nonunion Tissue Contains Osteoblast Lineage Cells and E-BMP-2 Activates Osteogenic and Chondrogenic Differentiation.

  Ryo Yoshikawa, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Kenichi Sawauchi, Kyohei Takase, Yuya Yamamoto, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  In this study, we examined the proliferation capability and osteogenic and chondrogenic differentiation potential of non-hypertrophic nonunion cells (NHNCs), and the effect of Escherichia coli-derived BMP-2 (E-BMP-2) on them. We enrolled five patients with non-hypertrophic nonunion. NHNCs isolated from nonunion tissue sampled during surgery were cultured, passaged, counted every 14 days, and analyzed. NHNCs were homogenous fibroblastic adherent cells and long-lived through at least 10 passages, with a slight decline. The cells were consistently positive for mesenchymal stem cell-related markers CD73 and CD105, and negative for the hematopoietic markers CD14 and CD45. NHNCs could differentiate into osteoblast lineage cells; however, they did not have strong calcification or sufficient chondrogenic differentiation capability. E-BMP-2 did not affect the proliferative capability of the cells but improved their osteogenic differentiation capability by increasing alkaline phosphatase activity and upregulating the gene expression of osterix, bone sialoprotein, and osteocalcin. E-BMP-2 enhanced their chondrogenic differentiation capability by upregulating the gene expression of aggrecan and collagen type II. We showed, for the first time, that NHNCs have the capacity to differentiate into osteoblast-lineage cells, although the chondrogenic differentiation potential was poor. Local application of E-BMP-2 with preservation of nonunion tissue is a potential treatment option for non-hypertrophic nonunion.

  Nov. 2022, Current issues in molecular biology, 44(11) (11), 5562 - 5578, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 脛骨病的骨折を生じた骨アミロイドーシスの一例

  山本 茜, 福井 友章, 大江 啓介, 新倉 隆宏, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2022, 中部日本整形外科災害外科学会雑誌, 65(秋季学会) (秋季学会), 310 - 310, Japanese


• 炭酸ガス経皮吸収療法と低出力超音波パルス療法(LIPUS)の併用はラットの骨折治癒を促進する

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1550 - S1550, Japanese


• Masquelet法 Induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1639 - S1639, Japanese


• Non-hypertrophic nonunionには骨分化能を有する細胞が存在し、E-BMP-2により骨・軟骨分化能が促進される

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 小田 崇弘, 澤内 健一, 高瀬 恭平, 山本 裕也, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1643 - S1643, Japanese


• 骨折遷延治癒、偽関節のメカニズムから臨床応用へ 炭酸ガス経皮吸収による骨癒合促進

  新倉 隆宏, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1734 - S1734, Japanese


• 骨組織由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 吉川 遼, 澤内 健一, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2022, 日本整形外科学会雑誌, 96(8) (8), S1878 - S1878, Japanese


• Management of Infected Non-union Following Femoral Shaft Fracture in a Patient with Klippel-Trenaunay Syndrome: A Case Report.

  Tetsuro Kurashina, Tomoaki Fukui, Keisuke Oe, Kenichi Sawauchi, Ryosuke Kuroda, Takahiro Niikura

  INTRODUCTION: The etiology of Klippel-Trenaunay syndrome (KTS) has a significant impact on the management of patient requiring surgical interventions. We report the strategies employed to address an infected non-union in a patient with KTS. CASE REPORT: The patient was transported to an initial treating hospital with femoral shaft fracture after experiencing a fall. The patient was diagnosed with KTS due to vascular malformations identified after severe intraoperative hemorrhaging. An open reduction and internal fixation was performed to stabilize the bone. Nine months after surgery, the patient was transferred to our hospital due to lack of healing with infected non-union. We prioritized treating the infection and plate displacement, and subsequently performed intramedullary nailing. Infection and intraoperative hemorrhaging were successfully controlled and bone union was confirmed 6 months after surgery. CONCLUSION: The key factors to minimize procedural complications are sufficient preoperative evaluation and planning, surgical skill, and perioperative resource management.

  Jul. 2022, Journal of orthopaedic case reports, 12(7) (7), 38 - 41, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 転移性骨腫瘍(切迫骨折の治療) 寛骨臼転移性骨腫瘍に対して病巣掻爬後に内固定および骨セメント充填を行った3例

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S68 - S68, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化について 多施設共同研究

  大江 啓介, 新倉 隆宏, 福井 友章, 高原 俊介, 岩倉 崇, 角田 雅也, 櫻井 敦志, 正田 悦朗, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S217 - S217, Japanese


• 患者立脚型機能評価による上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2022, 骨折, 44(Suppl.) (Suppl.), S268 - S268, Japanese


• 創外固定治療とMasquelet法のコラボレーション

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本四肢再建・創外固定学会, Apr. 2022, 日本四肢再建・創外固定学会雑誌, 33, 161 - 161, Japanese


• KLF15を介した筋萎縮の分子機構の解明

  平田 悠, 野村 和弘, 加藤 大輔, 橘 吉寿, 新倉 隆宏, 内山 奏, 細岡 哲也, 福井 友章, 大江 啓介, 黒田 良祐, 原 雄二, 安達 貴弘, 柴崎 貢志, 和氣 弘明, 小川 渉

  (一社)日本糖尿病学会, Apr. 2022, 糖尿病, 65(Suppl.1) (Suppl.1), S - 122, Japanese


• KLF15を介した筋萎縮の分子機構の解明

  平田 悠, 野村 和弘, 加藤 大輔, 橘 吉寿, 新倉 隆宏, 内山 奏, 細岡 哲也, 福井 友章, 大江 啓介, 黒田 良祐, 原 雄二, 安達 貴弘, 柴崎 貢志, 和氣 弘明, 小川 渉

  (一社)日本糖尿病学会, Apr. 2022, 糖尿病, 65(Suppl.1) (Suppl.1), S - 122, Japanese


• Safety of 222 nm UVC irradiation to the surgical site in a rabbit model.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Aiko Nishiaki, Rena Kaigome, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Keisuke Oe, Michael R Hamblin, Ryosuke Kuroda

  For the prevention of surgical site infection (SSI), continuous disinfection could be helpful. Short wavelength ultraviolet radiation C (UVC) is highly bactericidal but shows cytotoxicity. Radiation of UVC with a wavelength of 222 nm to the skin is considered to be safe because it only reaches the stratum corneum. However, the safety of 222 nm irradiation to the surgical field not covered with skin is unknown. The purpose of this study was to examine the safety of 222 nm UVC irradiation on a surgical field in a rabbit model. Five types of tissue were surgically exposed and irradiated with 222 or 254 nm UVC. Immunohistological assessment against cyclobutane pyrimidine dimer (CPD), an index of DNA damage by UVC, was performed. The CPD-positive cell rate was significantly higher in the 254 nm group than in the other groups in all tissues. A 222 nm group showed significantly more CPD than control in fat tissue, but no significant difference in all other tissues. In fat tissue collected 24 h after irradiation, the 254 nm group showed higher CPD than the other groups, while the 222 nm group had reduced to the control level. These data suggest that 222 nm UVC irradiation could be a new method to safely prevent SSI.

  Mar. 2022, Photochemistry and photobiology, 98(6) (6), 1365 - 1371, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy

  Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa

  American Society for Clinical Investigation, Mar. 2022, Journal of Clinical Investigation

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S469 - S469, Japanese


• 小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田 亮介, 新倉 隆宏, 薩摩 眞一, 小林 大介, 衣笠 真紀, 八尋 俊輔, 北澤 大也, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S508 - S508, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S839 - S839, Japanese


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese


• 難治性骨折に対する自家CD34陽性細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• Endochondral Bone Tissue Engineering Using Human Induced Pluripotent Stem Cells.

  Michio Arakura, Sang Yang Lee, Tomoaki Fukui, Keisuke Oe, Shunsuke Takahara, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects. Impact statement We investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in vivo. We implanted two different clones of human induced pluripotent stem cells into a radial bone defect model. Eleven of 11 (100%) and 7 of 10 (70%) radii in the 201B7 and 454E2 cell-derived pellet transplantation groups, respectively, showed bone union, which were significantly higher than those in the control group [only 2 of 11 radii (18%)]. Overall, our results support the use of iMSC-based cartilage grafts recapitulating the morphogenetic process of endochondral bone ossification for repairing large bone defects.

  Feb. 2022, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Low-Intensity Pulsed Ultrasound Promotes Osteogenic Differentiation of Reamer-Irrigator-Aspirator Graft-Derived Cells in Vitro.

  Kenichi Sawauchi, Tomoaki Fukui, Keisuke Oe, Yohei Kumabe, Takahiro Oda, Ryo Yoshikawa, Kyohei Takase, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.

  Feb. 2022, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.

  Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.

  Jan. 2022, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Combined treatment using cross-leg free flap and the Masquelet technique: a report of two cases.

  Takeo Osaki, Yasuko Hasegawa, Ryosuke Tamura, Tomoaki Fukui, Keisuke Oe, Takahiro Niikura, Tadashi Nomura, Kazunobu Hashikawa, Hiroto Terashi

  We introduce a treatment that combines the cross-leg free flap with the Masquelet technique and describe two cases using this method for bone and soft tissue reconstruction. Both patients were successfully treated and ambulatory. This novel method can be safely performed using the delay technique, indocyanine-green angiography and near-infrared spectroscopy.

  2022, Case reports in plastic surgery & hand surgery, 9(1) (1), 99 - 104, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Continuous local antibiotic perfusion: A treatment strategy that allows implant retention in fracture-related infections.

  Akihiro Maruo, Takahiro Oda, Ryowa Mineo, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: Fracture-related infections are difficult to treat because of the formation of biofilms around implants. Systemic antibiotics are notoriously ineffective against biofilms due to their insufficient penetration of tissues with poor vascularity. The goal of treating fracture-related infections is to achieve bone union while retaining the implant. Our proposal of continuous local antibiotic perfusion is a sustained local delivery system of sufficient antibiotics to bone and soft tissue infection sites, including to bone marrow via needles as intra-medullary antibiotics perfusion and to soft-tissue via double-lumen subcutaneous tubes as intra-soft tissue perfusion. METHODS: In this study, we examined the outcomes of 40 patients treated for fracture-related infections using continuous local antibiotic perfusion between 2015 and 2021 at Steel Memorial Hirohata Hospital, Himeji, Japan. RESULT: The antibiotic used for continuous local antibiotic perfusion was gentamicin in all cases. Implant removal was required in five patients. Two patients required toe amputation and knee arthrodesis, while the remaining 38 patients achieved fracture union. Only one case of transient acute renal injury as a systemic side effect was observed, but it soon resolved. The blood concentration of gentamicin could be adjusted to less than the trough level. CONCLUSIONS: Continuous local antibiotic perfusion is a novel local drug delivery system that has the potential of delivering sufficient concentrations of antibiotics with few systemic side effects; it is a useful option for the treatment of fracture-related infections.

  2022, Journal of orthopaedic surgery (Hong Kong), 30(2) (2), 10225536221111902 - 10225536221111902, English, International magazine

  Scientific journal


• Simulation Of Bone Fracture Healing Process Using Ultrasound And BMD Data.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  2022, ICMLC, 259 - 264

  International conference proceedings


• A Case of Nonunion with Ballooning Deformity after Periprosthetic Humeral Fracture.

  Yutaka Matsumiya, Keisuke Oe, Tomoaki Fukui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We report a very rare case of nonunion with ballooning deformity of the humeral bone after a periprosthetic humeral fracture nonunion. Case Report: A 79-year-old woman underwent hemiarthroplasty 19 years ago for her proximal humerus fracture. She injured her right humeral diaphysis (stem distal end fracture) 6 years ago. She underwent revision hemiarthroplasty with long stem, but bony union was not obtained, and her right upper limb function was subsequently abolished due to extreme instability and pain in her right upper arm. She was then referred to our hospital for further treatment. X-ray showed nonunion in the humeral diaphysis and a severe ballooning deformity in the distal humeral bone fragment. Due to the advanced age and low activity of the patient, we chose total humerus replacement surgery instead of osteosynthesis. After the surgery, her upper arm pain and instability immediately improved. Three years after the last surgery, there have been no implant failures, and the upper arm is stable and painless. Conclusion: Although there are some reports of total humerus replacement as surgical treatment for humeral tumor and severe periprosthetic fracture, we found no reports of such ballooning deformity around the nonunion site. Total humerus replacement can be one of the treatment options in cases where nonunion surgery is extremely difficult, depending on the patient's age and activities of daily living.

  Jan. 2022, Journal of orthopaedic case reports, 12(1) (1), 89 - 91, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Treatment of Chronic Osteomyelitis of the Femur by Intramedullary Antibiotic Perfusion (iMAP): A Case Report.

  Keisuke Oe, Akihiro Maruo, Tomoaki Fukui, Hirotsugu Muratsu, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Chronic osteomyelitis is difficult to cure definitively, because local areas are often covered with sequestrum and scar tissues with a poor blood flow; these may render systemic antibiotic administration ineffective. We present a case of chronic osteomyelitis that was successfully treated with continuous local antibiotic perfusion (CLAP) through an intramedullary antibiotic perfusion (iMAP) pin. Case Presentation: A 65-year-old man who suffered an episode of the right femoral osteomyelitis at the age of 15 years experienced a relapse at the age of 63 years. Systemic administration of antibiotics could not control the infection; thus, a surgery was performed. A bone marrow needle (i.e., an iMAP pin; diameter: 3 mm) was percutaneously inserted, from the front, distally and proximally to the cystic lesion in the distal femur. After washing through the iMAP pins, the pins were left indwelling. A closed drain tube was placed on the bone surface, which was close to the fistula of the bone marrow lesion. CLAP therapy was then initiated. Gentamicin was continuously infused through the iMAP pin at a rate of 2 mL/h and drained using the tube. Accordingly, 2.4 mg/mL, 1.2 mg/mL, and 1.2 mg/mL of gentamicin were administered for 4 days using two iMAP pins, for 5-8 days using two iMAP pins, and for 9-15 days using one iMAP pin, respectively, with a syringe pump. The iMAP pins and the drain tube were removed 15 days after the initiation of the CLAP therapy. The C-reactive protein level normalized 25 days postoperatively. The patient recovered full range of motion of the knee joint and recreational sports activity without recurrence of osteomyelitis for 5 years after the therapy. Conclusions: CLAP therapy allows local administration of a sufficient concentration of antibiotics and device removal after treatment is simple. This may be a novel treatment for chronic osteomyelitis.

  Dec. 2021, Journal of orthopaedic case reports, 11(12) (12), 35 - 38, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• 糖尿病性骨症の病態と臨床疫学 整形外科から見た糖尿病患者の骨折とそのマネジメント

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2021, 日本骨粗鬆症学会雑誌, 7(Suppl.1) (Suppl.1), 165 - 165, Japanese


• Klippel-Trenaunay症候群の患者に生じた大腿骨感染性偽関節に対する治療経験

  倉科 徹郎, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2021, 中部日本整形外科災害外科学会雑誌, 64(秋季学会) (秋季学会), 215 - 215, Japanese


• 222nm UVCのヒトに対する安全性と有効性

  新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本環境感染学会, Sep. 2021, 日本環境感染学会総会プログラム・抄録集, 36回, 204 - 204, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSによる骨分化誘導

  高瀬 恭平, 新倉 隆宏, 福井 友章, 大江 啓介, 小田 崇弘, 澤内 健一, 吉川 遼, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1697 - S1697, Japanese


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 偽関節患者への自家末梢血CD34陽性細胞移植

  大江 啓介, 新倉 隆宏, 福井 友章, 美舩 泰, 松本 知之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1464 - S1464, Japanese


• 偽関節、感染性偽関節の基礎研究と臨床応用 Masquelet法の根幹をなすinduced membraneについての組織学的研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1465 - S1465, Japanese


• ヒトinduced membraneにおけるbone morphogenetic proteins(BMP)発現の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 高瀬 恭平, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1689 - S1689, Japanese


• Non-hypertrophic nonunion cellsの増殖能・骨分化能に対するE-BMP-2の効果の検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 高瀬 恭平, 澤内 健一, 小田 崇弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2021, 日本整形外科学会雑誌, 95(8) (8), S1814 - S1814, Japanese


• Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Current treatment options for osteoporosis primarily involve pharmacotherapies, but they are often accompanied by undesirable side effects. Utilization of mechanical stress which can noninvasively induce bone formation has been suggested as an alternative to conventional treatments. Here, we examined the efficacy of mechanical stress induced by electrical stimulation, radial extracorporeal shock waves, and ultrasound for estrogen-deficient osteoporosis. Female Wistar rats were divided into following five groups: sham-operated group, untreated after ovariectomy, and treated with electrical stimulation, radial extracorporeal shock wave, or ultrasound starting at 8 weeks after ovariectomy for 4 weeks. Trabecular bone architecture of the femur was assessed by micro-CT and its biomechanical properties were obtained by mechanical testing. The femurs were further evaluated by histochemical, immunohistochemical, and real-time PCR analyses. Radial extracorporeal shock wave and ultrasound treatment improved trabecular bone microarchitecture and bone strength in osteoporotic rats, but not electrical stimulation. The shock wave decreased osteoclast activity and RANKL expression. The exposure of ultrasound increased osteoblast activity and β-catenin-positive cells, and they decreased sclerostin-positive osteocytes. These findings suggest that mechanical stress induced by radial extracorporeal shock wave and ultrasound can improve estrogen-deficient bone loss and bone fragility through promoted bone formation or attenuated bone resorption.

  Aug. 2021, Calcified tissue international, 109(2) (2), 215 - 229, English, International magazine

  Scientific journal


• Correction to: Utilization of Mechanical Stress to Treat Osteoporosis: The Effects of Electrical Stimulation, Radial Extracorporeal Shock Wave, and Ultrasound on Experimental Osteoporosis in Ovariectomized Rats.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Aug. 2021, Calcified tissue international, 109(2) (2), 230 - 230, English, International magazine


• トップアスリートの外傷・障害とその治療

  黒田 良祐, 大江 啓介, 福井 友章, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S13 - S13, Japanese


• AFFの治療 インプラント周囲に発生した非定型大腿骨骨折について

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S30 - S30, Japanese


• 治療に難渋する骨折 偽関節に対する低出力超音波パルス療法の有効性

  李 相亮, 川崎 恵吉, 稲垣 克記, 福井 友章, 大江 啓介, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S40 - S40, Japanese


• 治療に難渋する骨折 偽関節治療への新たなアプローチ

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S41 - S41, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折の治療経過に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 正田 悦朗, 吉田 圭二, 伊藤 研二郎, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S170 - S170, Japanese


• 有限要素法を用いたReamer Irrigator Aspirator施行前後の大腿骨強度評価の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 長宗 高樹

  (一社)日本骨折治療学会, Jul. 2021, 骨折, 43(Suppl.) (Suppl.), S198 - S198, Japanese


• Ultrasound Frequency-Based Monitoring for Bone Healing.

  Yohei Kumabe, Keisuke Oe, Masakazu Morimoto, Naomi Yagi, Tomoaki Fukui, Ryosuke Kuroda, Yutaka Hata, Takahiro Niikura

  Correct assessment of the bone healing process is required for the management of limb immobilization during the treatment of bone injuries, including fractures and defects. Although the monitoring of bone healing using ultrasound poses several advantages regarding cost and ionizing radiation exposure compared with other dominant imaging methods, such as radiography and computed tomography (CT), traditional ultrasound B-mode imaging lacks reliability and objectivity. However, the body structures can be quantitatively observed by ultrasound frequency-based methods, and therefore, the disadvantages of B-mode imaging can be overcome. In this study, we created a femoral bone hole model of a rat and observed the bone healing process using the quantitative ultrasound method and micro-CT, which provides a reliable assessment of the tissue microstructure of the bone. This study analyzed the correlation between these two assessments. The results revealed that the quantitative ultrasound measurements correlated with the CT measurements for rat bone healing. This ultrasound frequency-based method could have the potential to serve as a novel modality for quantitative monitoring of bone healing with the advantages of being less invasive and easily accessible. Impact statement Bone healing monitoring with ultrasound is advantageous as it is less invasive and easily accessible; however, the traditional B-mode method lacks reliability and objectivity. This study demonstrated that the proposed ultrasound frequency-based monitoring method can quantitatively observe bone healing and strongly correlates with the computed tomography measurements for rat bone healing. This method has the potential to become a reliable modality for monitoring bone healing.

  Jun. 2021, Tissue engineering. Part C, Methods, 27(6) (6), 349 - 356, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Histological analysis of induced membranes in patients whose bone defects were treated with the Masquelet technique to identify factors affecting the vascularity of induced membranes.

  Takahiro Niikura, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Yoshitada Sakai, Tomoo Itoh, Ryosuke Kuroda

  BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.

  Apr. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Bilateral Tibial Proximal Fractures Caused by Secondary Osteomalacia due to Autoimmune Polyendocrine Syndrome Type 2: A Case Report.

  Daisuke Nakagawa, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Hypophosphatemic osteomalacia can be overlooked or confused with other musculoskeletal disorders due to the variety of associated clinical, laboratory, and radiographic findings. If osteomalacia is diagnosed early and the fractures are not displaced, they often heal with nutritional supplements, but, if they progress to displaced fractures, they may require surgical intervention. Case Report: We present a case of secondary osteomalacia due to autoimmune polyendocrine syndrome Type 2 due to this condition, the patient developed bilateral tibial proximal fractures and her varus deformity had progressed. No clear indication of the timing for surgery for adults with osteomalacia has been reported. However, medical treatment improves the symptoms of osteomalacia and it is reported that in children, appropriate level of the serum phosphate (P) should be attained and maintained for the successful bone healing after osteotomy. Therefore, we prioritized pharmacological treatment and prescribed surgery after confirming that the value of serum phosphate P had been improved to recommended levels (2.5-3.5 mg/dl). We performed high tibial osteotomy for the right side and gradual correction by an external fixation for the left tibia, because of more severe deformation, and converted to an internal fixation to shorten the treatment period. During conversion, we performed the operation with a locking plate by the minimal invasive plate osteosynthesis method (MIPO). Conclusion: We conclude that the use of different deformity correction methods, depending on the degree of deformity, and the pharmacological treatment of osteomalacia may lead to favorable results.

  Apr. 2021, Journal of orthopaedic case reports, 11(4) (4), 14 - 17, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• 【骨折に対する積極的保存療法】LIPUSによる骨折の積極的保存療法 超音波骨折治療を有効活用するための照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 261 - 266, Japanese


• 偽関節症例における骨SPECT定量評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S152 - S152, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(2) (2), S153 - S153, Japanese


• 骨修飾薬使用中の悪性腫瘍骨転移患者に発生した非定型大腿骨骨折に関する多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 森下 雅之, 藤田 郁夫, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2021, 日本整形外科学会雑誌, 95(3) (3), S644 - S644, Japanese


• 【骨折に対する積極的保存療法 基礎編】難治性骨折に対する再生医療 自家末梢血CD34陽性細胞移植

  黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章, 美舩 泰, 松本 知之

  (株)医学書院, Mar. 2021, 臨床整形外科, 56(3) (3), 241 - 245, Japanese


• Effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on rat bone defect healing.

  Shota Inoue, Junpei Hatakeyama, Hitoshi Aoki, Hiroshi Kuroki, Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Ryosuke Kuroda, Toshihiro Akisue, Hideki Moriyama

  Fractures associated with osteoporosis are a major public health concern. Current treatments for fractures are limited to surgery or fixation, leading to long-term bedrest, which is linked to increased mortality. Alternatively, utilization of physical agents has been suggested as a promising therapeutic approach for fractures. Here, we examined the effects of ultrasound, radial extracorporeal shock waves, and electrical stimulation on normal or osteoporotic fracture healing. Femoral bone defects were created in normal or ovariectomized rats. Rats were divided into four groups: untreated, and treated with ultrasound, shock waves, or electrical stimulation after surgery. Samples were collected at 2 or 4 weeks after surgery, and the healing process was evaluated with micro-CT, histological, and immunohistochemical analyses. Ultrasound at intensities of 0.5 and 1.0 W/cm2 , but not 0.05 W/cm2 , accelerated new bone formation. Shock wave exposure also increased newly formed bone, but formed abnormal periosteal callus around the defect site. Conversely, electrical stimulation did not affect the healing process. Ultrasound exposure increased osteoblast activity and cell proliferation and decreased sclerostin-positive osteocytes. We demonstrated that higher-intensity ultrasound and radial extracorporeal shock waves accelerate fracture healing, but shock wave treatment may increase the risk of periosteal callus formation.

  Feb. 2021, Annals of the New York Academy of Sciences, 1497(1) (1), 3 - 14, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion.

  Keisuke Oe, Feibi Zeng, Tomoaki Fukui, Munenobu Nogami, Takamichi Murakami, Tomoyuki Matsumoto, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. METHODS: We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. RESULTS: The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). CONCLUSIONS: SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

  Feb. 2021, Journal of orthopaedic surgery and research, 16(1) (1), 125 - 125, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Intra-medullary antibiotics perfusion (iMAP) for the control of fracture-related infection early after osteosynthesis.

  Akihiro Maruo, Takahiro Oda, Hidetoshi Miya, Hirotsugu Muratsu, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  PURPOSE: In our hospital, cases of bone and soft tissue infections have been treated with continuous local antibiotics perfusion that allows for continuous circulation of antibiotics throughout the infected lesion. We termed this treatment "intramedullary antibiotics perfusion (iMAP)" for bone infection such as fracture-related infection (FRI) and "intrasoft tissue antibiotics perfusion" for soft tissue infection. Many cases are treated with both modalities. To introduce iMAP, this study focused on the patients with FRI treated with iMAP and reviewed their treatment outcomes. METHODS: We included 10 patients with FRI treated with iMAP between 2004 and 2017. The iMAP needles were inserted near the infected lesion, and an aminoglycoside antimicrobial was continuously administered. Patient characteristics, pathogenic bacteria, administered antibiotics, duration of administration, concentrations of antibiotics in blood and leachate fluid, fracture union rate, implant retention rate, and complications were studied. RESULTS: The mean age of patients was 59.9 years, and the mean follow-up period was 2.5 years. Affected bones were the tibia (n = 8), humerus (n = 1), and fibula (n = 1). Deep infections developed on average 29.9 days after osteosynthesis. Pathogenic bacteria were methicillin-susceptible Staphylococcus aureus (n = 6), methicillin-resistant S. aureus (n = 2), and unknown (n = 2). Average iMAP duration was 17.1 days. In all patients, infection was eradicated while preserving the implants, and fracture union was achieved without complications. CONCLUSION: iMAP is a novel local drug delivery system allowing high concentrations of antibiotics to be administered without complications and is useful in the treatment of FRI.

  2021, Journal of orthopaedic surgery (Hong Kong), 29(3) (3), 23094990211051492 - 23094990211051492, English, International magazine

  Scientific journal


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  (一社)日本核医学会, 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English


• On Degree of Bone Healing for Bone Fracture Treatment by Ultrasonic Wave.

  Takumi Ueyama, Yohei Kumabe, Keisuke Oe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Masakazu Morimoto, Naomi Yagi, Yutaka Hata

  IEEE, 2021, ICMLC, 1 - 5

  International conference proceedings


• A Case of Femoral Neck Insufficiency Fracture due to Tumor-Induced Osteomalacia.

  Yu Inoue, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.

  2021, Case reports in orthopedics, 2021, 6668006 - 6668006, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 【超音波による骨折治療】偽関節に対する超音波治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• Closed Compression Nailing Using a New-Generation Intramedullary Nail without Autologous Bone Grafting for Humeral Shaft Nonunion.

  Genta Fukumoto, Tomoaki Fukui, Keisuke Oe, Atsuyuki Inui, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Although the recommended treatment for humeral shaft nonunion is compression plating with autologous bone grafting, we treated a case of humeral shaft nonunion with an intramedullary nail (IMN) without bone grafting. Presentation of Case. Osteosynthesis with IMN was performed on a 24-year-old man with a humeral shaft fracture at another hospital. However, bony union was not obtained 1 year after the first surgery, and he was referred to our institution. We treated the nonunion with exchange nailing without autologous bone grafting using compression function of the nail, leading to bony union at 7 months postoperatively. At the final follow-up 2 years and 4 months postoperatively, the patient had full range of motion in the left shoulder and elbow joints. Discussion. Compression plating with autologous bone grafting is reported to be the gold standard for the treatment of humeral shaft nonunion. IMN is advantageous for minimal invasion; however, the conventional type of IMN cannot apply compression force between fragments and does not have sufficient stability against rotational force. In this case, we used an IMN that could apply compression between the fragments and which had rotational stability via many screws. We did not perform bone grafting because the current nonunion was adjudged to be biologically active, and we achieved good functional results. Conclusion: We treated humeral shaft nonunion using IMN with compression, but without bone grafting, leading to successful clinical outcomes. This strategy might be an appropriate choice for the treatment of humeral shaft nonunion with biological activity.

  2021, Case reports in orthopedics, 2021, 5548729 - 5548729, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• 【超音波による骨折治療】偽関節に対する超音波治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  金原出版(株), Jan. 2021, 整形・災害外科, 64(1) (1), 61 - 69, Japanese


• Bromodomain-containing-protein-4 and cyclin-dependent-kinase-9 inhibitors interact synergistically in vitro and combined treatment reduces post-traumatic osteoarthritis severity in mice.

  T Fukui, J H N Yik, B Doyran, J Davis, A K Haudenschild, I E Adamopoulos, L Han, D R Haudenschild

  OBJECTIVE: Joint injury rapidly induces expression of primary response genes (PRGs), which activate a cascade of secondary genes that destroy joint tissues and initiate post-traumatic osteoarthritis (PTOA). Bromodomain-containing-protein-4 (Brd4) and cyclin-dependent-kinase-9 (CDK9) cooperatively control the rate-limiting step of PRG transactivation, including pro-inflammatory genes. This study investigated whether Brd4 and CDK9 inhibitors suppress inflammation and prevent PTOA development in vitro and in a mouse PTOA model. METHODS: The effects of Brd4 and CDK9 inhibitors (JQ1 and Flavopiridol) on PRG and associated secondary damage were rigorously tested in different settings. Short-term effects of inflammatory stimuli (IL-1β, IL-6, TNF) on human chondrocyte PRG expression were assessed by RT-PCR and microarray after 5-h. We quantified glycosaminoglycan release from IL-1β-treated bovine cartilage explants after 3-6 days, and osteoarthritic changes in mice after ACL-rupture using RT-PCR (2-24hrs), in vivo imaging of MMP activity (24hrs), AFM-nanoindentation (3-7days), and histology (3days-4wks). RESULTS: Flavopiridol and JQ1 inhibitors act synergistically, and a combination of both almost completely prevented the activation of most IL-1β-induced PRGs in vitro by microarray analysis, and prevented IL-1β-induced glycosaminoglycan release from cartilage explants. Mice given the drug combination showed reduced IL-1β and IL-6 expression, less in vivo MMP activity, and lower synovitis (1.5 vs 4.9) and OARSI scores (2.8 vs 6.0) than untreated mice with ACL-rupture. CONCLUSIONS: JQ1 and Flavopiridol work synergistically to reduce injury response after joint trauma, suggesting that targeting Brd4 and/or CDK9 could be a viable strategy for PTOA prevention and treatment of early OA.

  Jan. 2021, Osteoarthritis and cartilage, 29(1) (1), 68 - 77, English, International magazine

  Scientific journal


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本筋学会, Dec. 2020, 日本筋学会学術集会プログラム・抄録集, 6回, 46 - 46, Japanese


• Transcutaneous CO2 application accelerates fracture repair in streptozotocin-induced type I diabetic rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Keisuke Oe, Yu Kuroiwa, Yohei Kumabe, Kenichi Sawauchi, Ryo Yoshikawa, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda

  INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.

  Dec. 2020, BMJ open diabetes research & care, 8(2) (2), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高齢者の肘関節脱臼に対してテープ付きアンカーを用いて靱帯修復を行った1例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Nov. 2020, 中部日本整形外科災害外科学会雑誌, 63(6) (6), 899 - 900, Japanese


• Ultrasonic Diagnosis for Bone Fracture Healing Process

  Satoshi Kimura, Keisuke Oe, Yohei Kumabe, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda, Naomi Yagi, Yutaka Hata

  IEEE, Nov. 2020, 2020 IEEE 50th International Symposium on Multiple-Valued Logic (ISMVL)

  International conference proceedings


• Effects of the duration of transcutaneous CO2 application on the facilitatory effect in rat fracture repair.

  Takahiro Oda, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yoshitada Sakai, Toshihiro Akisue, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.

  Sep. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本抗加齢医学会, Sep. 2020, 日本抗加齢医学会総会プログラム・抄録集, 20回(1) (1), 181 - 181, Japanese


• Infected Gustilo IIIB open knee joint fracture treated with an antimicrobial iodine-supported megaprosthesis: A case report.

  Shin Osawa, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Hiroyuki Tsuchiya, Takahiro Niikura

  Aug. 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 28(2) (2), 495 - 498, English, Domestic magazine

  Link to Kobe Univ. Repository (Kernel)


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本糖尿病学会, Aug. 2020, 糖尿病, 63(Suppl.1) (Suppl.1), S - 238, Japanese


• Percutaneous CO2Treatment Accelerates Bone Generation during Distraction Osteogenesis in Rabbits

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2020, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935

  Scientific journal


• Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

  Yohei Kumabe, Tomoaki Fukui, Shunsuke Takahara, Yu Kuroiwa, Michio Arakura, Keisuke Oe, Takahiro Oda, Kenichi Sawauchi, Takehiko Matsushita, Tomoyuki Matsumoto, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.

  Aug. 2020, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, English, International magazine

  Scientific journal


• Clinical experience of the use of reamer irrigator aspirator in Japanese patients: A report of the first 42 cases.

  Takahiro Niikura, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.

  May 2020, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Altered microRNA profile during fracture healing in rats with diabetes.

  Shunsuke Takahara, Sang Yang Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Michio Arakura, Yoshitada Sakai, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  BACKGROUND: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that regulate gene expression. There is increasing evidence that some miRNAs are involved in the pathology of diabetes mellitus (DM) and its complications. We hypothesized that the functions of certain miRNAs and the changes in their patterns of expression may contribute to the pathogenesis of impaired fractures due to DM. METHODS: In this study, 108 male Sprague-Dawley rats were divided into DM and control groups. DM rats were created by a single intravenous injection of streptozotocin. Closed transverse femoral shaft fractures were created in both groups. On post-fracture days 5, 7, 11, 14, 21, and 28, miRNA was extracted from the newly generated tissue at the fracture site. Microarray analysis was conducted with miRNA samples from each group on post-fracture days 5 and 11. The microarray findings were validated by real-time polymerase chain reaction (PCR) analysis at each time point. RESULTS: Microarray analysis revealed that, on days 5 and 11, 368 and 207 miRNAs, respectively, were upregulated in the DM group, compared with the control group. The top four miRNAs on day 5 were miR-339-3p, miR451-5p, miR-532-5p, and miR-551b-3p. The top four miRNAs on day 11 were miR-221-3p, miR376a-3p, miR-379-3p, and miR-379-5p. Among these miRNAs, miR-221-3p, miR-339-3p, miR-376a-3p, miR-379-5p, and miR-451-5p were validated by real-time PCR analysis. Furthermore, PCR analysis revealed that these five miRNAs were differentially expressed with dynamic expression patterns during fracture healing in the DM group, compared with the control group. CONCLUSIONS: Our findings will aid in understanding the pathology of impaired fracture healing in DM and may support the development of molecular therapies using miRNAs for the treatment of impaired fracture healing in patients with DM.

  Apr. 2020, Journal of orthopaedic surgery and research, 15(1) (1), 135 - 135, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 外傷診療におけるCAOSの応用 難治骨折治療における3D実寸大骨モデルの応用

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本CAOS研究会・日本最小侵襲整形外科学会, Mar. 2020, 日本CAOS研究会・日本最小侵襲整形外科学会プログラム・抄録集, 14回・26回, 72 - 72, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese

  [Refereed]


• Limb Salvage for a Mangled Foot: A Case Report.

  Takahiro Oda, Keisuke Oe, Atsushi Sakurai, Tomoaki Fukui, Takahiro Niikura, Ryosuke Kuroda

  Introduction: It remains controversial whether amputation or limb salvage is the best approach for mangled foot cases because there are no clear criteria for treatment. We report a case of successful limb salvage for a mangled foot, with good outcomes. Case Report: The patient was a 30-year-old man who sustained a crush injury to his left foot and ankle and lower legs in a car crash; he had severe open left foot and ankle fracture and bilateral open tibial shaft fractures. Blood flow was maintained by the posterior tibial artery, and the tibial nerve was intact. We stabilized the ankle using Kirschner wires on the day of injury. Plastic surgeons were consulted for early soft tissue coverage. Final fixation was performed 12 weeks after flap grafting; we grafted an autologous bone on the defect, according to the Masquelet technique. Four months after the final surgery, fullweightbearing gait was initiated. The patient is now capable of walking independently, with no pain, and is highly satisfied. Conclusions: Limb salvage can be successfully performed even in a patient with a severely mangled foot. For successful salvage surgery with good outcomes, such patients should be managed by a team of experienced orthopedic and plastic surgeons from an early stage to achieve appropriate bone alignment and soft tissue coverage.

  2020, Journal of orthopaedic case reports, 9(6) (6), 58 - 61, English, International magazine


• Surgically Treated Nonunion following Ischial Tuberosity Avulsion Fracture of a 14-Year-Old Athlete.

  Yuta Nakamatsu, Tomoaki Fukui, Keisuke Oe, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda, Takahiro Niikura

  A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.

  2020, Case reports in orthopedics, 2020, 8531648 - 8531648, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans.

  Tomoaki Fukui, Takahiro Niikura, Takahiro Oda, Yohei Kumabe, Hiroyuki Ohashi, Masahiro Sasaki, Tatsushi Igarashi, Makoto Kunisada, Nozomi Yamano, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Chikako Nishigori, Ryosuke Kuroda

  INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.

  2020, PloS one, 15(8) (8), e0235948, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Ras associated with diabetes may play a role in fracture nonunion development in rats.

  Takahiro Oda, Takahiro Niikura, Tomoaki Fukui, Michio Arakura, Keisuke Oe, Yutaka Mifune, Shinya Hayashi, Tomoyuki Matsumoto, Takehiko Matsushita, Ryosuke Kuroda

  BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.

  Dec. 2019, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally invasive plate osteosynthesis for humeral shaft nonunion: A report of two cases.

  Yoshihito Suda, Keisuke Oe, Tomoaki Fukui, Yutaka Mifune, Atsuyuki Inui, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Introduction: We treated two cases of humeral shaft nonunion by minimally invasive plate osteosynthesis (MIPO) without autogenous bone grafting. Presntation of case: Case 1: An osteosynthesis with intramedullary nailing (IMN) was performed on a 17-year-old female for a humeral shaft fracture at another hospital; however, bony union was not obtained. We removed the nail and screws, then performed MIPO without autogenous bone grafting. At the final follow-up of 4 years after the surgery, she had obtained full range of motion.Case 2: Osteosynthesis with Rush pins had been performed in a 73-year-old female for a humeral shaft fracture at another hospital. Five months later, a revision surgery using IMN was performed at the same hospital; however, this led to nonunion. We removed the IMN and performed MIPO without autogenous bone grafting. At the final follow-up 2 years after surgery, she had obtained full range of motion. Discussion: The cause of nonunion is the lack of mechanical instability and/or biological activity. In these cases, from the findings of radiography and bone scintigraphy, mechanical instability was thought to be the primary cause; therefore, in order to enhance stability, we used a locking plate. Because we can see that these cases are biologically active, we decided not to use bone grafting. Both our cases successfully achieved bony union and excellent functional recovery using this method. Conclusion: We performed MIPO without exposure of the nonunion site and autogenous bone grafting in two cases of humeral shaft nonunion, and obtained successful clinical outcomes.

  Dec. 2019, Annals of medicine and surgery (2012), 48, 43 - 47, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Topical cutaneous application of carbon dioxide via a hydrogel for improved fracture repair: results of phase I clinical safety trial.

  Takahiro Niikura, Takashi Iwakura, Takashi Omori, Sang Yang Lee, Yoshitada Sakai, Toshihiro Akisue, Keisuke Oe, Tomoaki Fukui, Takehiko Matsushita, Tomoyuki Matsumoto, Ryosuke Kuroda

  BACKGROUND: Clinicians have very limited options to improve fracture repair. Therefore, it is critical to develop a new clinically available therapeutic option to assist fracture repair biologically. We previously reported that the topical cutaneous application of carbon dioxide (CO2) via a CO2 absorption-enhancing hydrogel accelerates fracture repair in rats by increasing blood flow and angiogenesis and promoting endochondral ossification. The aim of this study was to assess the safety and efficacy of CO2 therapy in patients with fractures. METHODS: Patients with fractures of the femur and tibia were prospectively enrolled into this study with ethical approval and informed consent. The CO2 absorption-enhancing hydrogel was applied to the fractured lower limbs of patients, and then 100% CO2 was administered daily into a sealed space for 20 min over 4 weeks postoperatively. Safety was assessed based on vital signs, blood parameters, adverse events, and arterial and expired gas analyses. As the efficacy outcome, blood flow at the level of the fracture site and at a site 5 cm from the fracture in the affected limb was measured using a laser Doppler blood flow meter. RESULTS: Nineteen patients were subjected to complete analysis. No adverse events were observed. Arterial and expired gas analyses revealed no adverse systemic effects including hypercapnia. The mean ratio of blood flow 20 min after CO2 therapy compared with the pre-treatment level increased by approximately 2-fold in a time-dependent manner. CONCLUSIONS: The findings of the present study revealed that CO2 therapy is safe to apply to human patients and that it can enhance blood flow in the fractured limbs. TRIAL REGISTRATION: This study has been registered in the UMIN Clinical Trials Registry (Registration number: UMIN000013641, Date of registration: July 1, 2014).

  Nov. 2019, BMC musculoskeletal disorders, 20(1) (1), 563 - 563, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Insufficiency and deficiency of vitamin D in elderly patients with fragility fractures of the hip in the Japanese population.

  Niikura T, Oe K, Sakai Y, Iwakura T, Fukui T, Nishimoto H, Hayashi S, Matsumoto T, Matsushita T, Maruo A, Yagata Y, Kishimoto K, Sakurai A, Kuroda R

  Sep. 2019, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Medial clavicle pseudarthrosis successfully treated with an inverted distal clavicle locking plate.

  Yu Sasaki, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Teruya Kawamoto, Yutaka Mifune, Ryosuke Kuroda, Takahiro Niikura

  Aug. 2019, Annals of medicine and surgery (2012), 44, 1 - 4, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Topical cutaneous application of CO2 accelerates bone healing in a rat femoral defect model.

  Yu Kuroiwa, Tomoaki Fukui, Shunsuke Takahara, Sang Yang Lee, Keisuke Oe, Michio Arakura, Yohei Kumabe, Takahiro Oda, Tomoyuki Matsumoto, Takehiko Matsushita, Toshihiro Akisue, Yoshitada Sakai, Ryosuke Kuroda, Takahiro Niikura

  May 2019, BMC musculoskeletal disorders, 20(1) (1), 237 - 237, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Escherichia coli-derived BMP-2-absorbed β-TCP granules induce bone regeneration in rabbit critical-sized femoral segmental defects.

  Yu Kuroiwa, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Takashi Iwakura, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda

  May 2019, International orthopaedics, 43(5) (5), 1247 - 1253, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Periprosthetic Femoral Fracture with Characteristics of Atypical Femoral Fracture.

  Shuya Tanaka, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Shinya Hayashi, Teruya Kawamoto, Ryosuke Kuroda, Takahiro Niikura

  Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.

  2019, Case reports in orthopedics, 2019, 1275369 - 1275369, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Humeral Shaft Non-union in a Patient with Osteogenesis Imperfecta Treated with Mandible Locking Plate Fixation: A Case Report.

  Shohei Sano, Keisuke Oe, Tomoaki Fukui, Shinya Hayashi, Ryosuke Kuroda, Takahiro Niikura

  Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.

  2019, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, English, International magazine

  [Refereed]


• Altered expression of microRNA during fracture healing in diabetic rats

  S. Takahara, S. Y. Lee, T. Iwakura, K. Oe, T. Fukui, E. Okumachi, T. Waki, M. Arakura, Y. Sakai, K. Nishida, R. Kuroda, T. Niikura

  British Editorial Society of Bone and Joint Surgery, Feb. 2018, Bone and Joint Research, 7(2) (2), 139 - 147, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Minimally Invasive Treatment for Tibial Malrotation after Locked Intramedullary Nailing.

  Kyohei Takase, Sang Yang Lee, Takahiro Waki, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Rotational malreduction is a potential complication of intramedullary nailing for tibial shaft fractures. We experienced a symptomatic case of a 24° externally rotated malunion that we treated with minimally invasive corrective osteotomy. A 49-year-old man sustained a tibial shaft spiral fracture with a fibula fracture. He had been initially treated elsewhere with a reamed statically locked intramedullary nail. Bone union had been obtained, but he complained of asymmetry of his legs, difficulty walking and running, and the inability to ride a bicycle. We decided to perform corrective osteotomy in a minimally invasive fashion. After a 1 cm incision was made at the original fracture site, osteotomy for the affected tibia was performed with an osteotome after multiple efforts at drilling around the nail with the aim of retaining it. Fibula osteotomy was also performed at the same level. Two Kirschner wires that created an affected rotational angle between the fragments were inserted as a guide for correction. The distal locking screws were removed. Correct rotation was regained by matching the two wires in a straight line. Finally, the distal locking screws were inserted into new holes. The patient obtained bony union and has returned to his preinjury activities with no symptoms.

  Hindawi Limited, 2018, Case reports in orthopedics, 2018, 4190670 - 4190670, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Locking plate osteosynthesis for a femoral fracture and subsequent nonunion in a patient with osteopetrosis.

  Tomoya Matsuo, Sang Yang Lee, Takashi Iwakura, Tomoaki Fukui, Keisuke Oe, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  2018, International journal of surgery case reports, 51, 395 - 399, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Rescue of ankylosing hip following open reduction and internal fixation of acetabular fracture by surgical resection of heterotopic ossification: A case report.

  Kazumichi Kitayama, Yohei Kawakami, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Takahiro Niikura

  2018, International journal of surgery case reports, 53, 107 - 111, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Triweekly administration of parathyroid hormone (1-34) accelerates bone healing in a rat refractory fracture model.

  Yohei Kumabe, Sang Yang Lee, Takahiro Waki, Takashi Iwakura, Shunsuke Takahara, Michio Arakura, Yu Kuroiwa, Tomoaki Fukui, Tomoyuki Matsumoto, Takehiko Matsushita, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura

  Dec. 2017, BMC musculoskeletal disorders, 18(1) (1), 545 - 545, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical Experience With the Use of Low-Intensity Pulsed Ultrasound (LIPUS) in the Treatment of Atypical Femoral Fractures.

  Sang Yang Lee, Takahiro Niikura, Takashi Iwakura, Tomoaki Fukui, Ryosuke Kuroda

  OBJECTIVE: The aim of this study was to report the clinical results of atypical femoral fractures (AFFs) treated with low-intensity pulsed ultrasound (LIPUS). MATERIALS AND METHODS: The data on AFFs that were surgically treated in our hospital from 2010 to 2016 was retrospectively analyzed. AFF was diagnosed based on the criteria defined by the second report of an ASBMR task force. RESULTS: Seven fractures in 6 cases were included in this study. Two fractures were referred to us as being nonunion. Five fractures were subtrochanteric fractures and 2 fractures were shaft fractures. Five fresh AFFs were fixed with an intramedullary nail and 2 nonunion fractures were fixed with plates. LIPUS was used in 6 fractures. Bone union was achieved in 5 fractures with the average time to union being 17 months (5-29). In 4 out of the 6 fractures treated with LIPUS, bone union was achieved after 14 months on average. In the other 2 LIPUS-treated fractures, bone union was not achieved even at 1 year after surgery. DISCUSSION: It is known that AFF healing tends to be very slow. Some case reports indicate that AFF healing might be accelerated by LIPUS. In the current series, the subtrochanteric fracture that was not treated with LIPUS healed at 29 months after surgery, which was much longer than the average time to union in the 5 fractures that were treated with LIPUS. Although our number of cases is small, LIPUS may be a potentially useful tool for accelerating AFF repair.

  Jul. 2017, Journal of orthopaedic trauma, 31(7) (7), S2, English, International magazine

  [Refereed]

  Scientific journal


• Altered expression of SDF-1 and CXCR4 during fracture healing in diabetes mellitus.

  Michio Arakura, Sang Yang Lee, Shunsuke Takahara, Etsuko Okumachi, Takashi Iwakura, Tomoaki Fukui, Kotaro Nishida, Masahiro Kurosaka, Ryosuke Kuroda, Takahiro Niikura

  Jun. 2017, International orthopaedics, 41(6) (6), 1211 - 1217, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics

  Yohei Kawakami, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Kunj G. Patel, Garth N. Walker, Masahiro Kurosaka, Ryosuke Kuroda

  2017, CURRENT STEM CELL RESEARCH & THERAPY, 12(1) (1), 3 - 13, English

  [Refereed]


• Therapeutic Potential of Endothelial Progenitor Cells in the Field of Orthopaedics.

  Yohei Kawakami, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Kunj G Patel, Garth N Walker, Masahiro Kurosaka, Ryosuke Kuroda

  2017, Current stem cell research & therapy, 12(1) (1), 3 - 13, English, International magazine

  [Refereed]

  Scientific journal


• In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury.

  Tomoaki Fukui, Elizabeth Tenborg, Jasper H N Yik, Dominik R Haudenschild

  May 2015, Biochemical and biophysical research communications, 460(3) (3), 741 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Superior Potential of CD34-Positive Cells Compared to Total Mononuclear Cells for Healing of Nonunion Following Bone Fracture.

  Tomoaki Fukui, Yutaka Mifune, Tomoyuki Matsumoto, Taro Shoji, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Hiroshi Akimaru, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Cantas Alev, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  2015, Cell transplantation, 24(7) (7), 1379 - 93, English, International magazine

  [Refereed]

  Scientific journal


• SDF-1/CXCR4 axis in Tie2-lineage cells including endothelial progenitor cells contributes to bone fracture healing.

  Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Ryosuke Kuroda, Tomoya Kuroda, Sang-Mo Kwon, Atsuhiko Kawamoto, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Masahiro Kurosaka, Takayuki Asahara

  Jan. 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1) (1), 95 - 105, English, International magazine

  [Refereed]

  Scientific journal


• Clinical Impact of Circulating CD34-Positive Cells on Bone Regeneration and Healing

  Ryosuke Kuroda, Tomoyuki Matsumoto, Yohei Kawakami, Tomoaki Fukui, Yutaka Mifune, Masahiro Kurosaka

  Jun. 2014, TISSUE ENGINEERING PART B-REVIEWS, 20(3) (3), 190 - 199, English

  [Refereed]

  Scientific journal


• Clinical impact of circulating CD34-positive cells on bone regeneration and healing.

  Ryosuke Kuroda, Tomoyuki Matsumoto, Yohei Kawakami, Tomoaki Fukui, Yutaka Mifune, Masahiro Kurosaka

  Jun. 2014, Tissue engineering. Part B, Reviews, 20(3) (3), 190 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of granulocyte colony stimulating factor-mobilized CD34+ cells for patients with femoral and tibial nonunion: pilot clinical trial.

  Ryosuke Kuroda, Tomoyuki Matsumoto, Takahiro Niikura, Yohei Kawakami, Tomoaki Fukui, Sang Yang Lee, Yutaka Mifune, Shin Kawamata, Masanori Fukushima, Takayuki Asahara, Atsuhiko Kawamoto, Masahiro Kurosaka

  Jan. 2014, Stem cells translational medicine, 3(1) (1), 128 - 34, English, International magazine

  [Refereed]

  Scientific journal


• A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.

  Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Ryosuke Kuroda, Hiroshi Akimaru, Yutaka Mifune, Taro Shoji, Tomoaki Fukui, Michio Asahi, Masahiro Kurosaka, Takayuki Asahara

  Sep. 2013, Laboratory investigation; a journal of technical methods and pathology, 93(9) (9), 1036 - 53, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic superiority for cartilage repair by CD271-positive marrow stromal cell transplantation.

  Yutaka Mifune, Tomoyuki Matsumoto, Satoshi Murasawa, Atsuhiko Kawamoto, Ryosuke Kuroda, Taro Shoji, Tomoya Kuroda, Tomoaki Fukui, Yohei Kawakami, Masahiro Kurosaka, Takayuki Asahara

  2013, Cell transplantation, 22(7) (7), 1201 - 11, English, International magazine

  [Refereed]

  Scientific journal


• Polyostotic fibrous dysplasia with epiphyseal involvement in long bones: a case report.

  Tomoaki Fukui, Teruya Kawamoto, Toshiaki Hitora, Yoshiki Yamagami, Toshihiro Akisue, Tetsuji Yamamoto

  Fibrous dysplasia (FD) is an uncommon, but well-known benign skeletal disorder. In cases affecting long bones, FD is commonly recognized to locate in the diaphyses or the metaphyses and to spare the epiphyses. In this paper, we present a rare case of polyostotic FD in a 13-year-old girl with unilateral multiple epiphyseal lesions arising in the femur, the tibia, and the fibula with the growth plates.

  2013, Case reports in orthopedics, 2013, 715402 - 715402, English, International magazine

  [Refereed]

  Scientific journal


• The accuracy of bone tunnel position using fluoroscopic-based navigation system in anterior cruciate ligament reconstruction.

  Yohei Kawakami, Takafumi Hiranaka, Tomoyuki Matsumoto, Yuichi Hida, Tomoaki Fukui, Harunobu Uemoto, Minoru Doita, Mitsuo Tsuji, Masahiro Kurosaka, Ryosuke Kuroda

  Aug. 2012, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 20(8) (8), 1503 - 10, English, International magazine

  [Refereed]

  Scientific journal


• Backout of the helical blade of proximal femoral nail antirotation and accompanying fracture nonunion.

  Takahiro Niikura, Sang Yang Lee, Tomoyuki Matsumoto, Tomoaki Fukui, Yohei Kawakami, Toshihiro Akisue, Ryosuke Kuroda, Masahiro Kurosaka

  Aug. 2012, Orthopedics, 35(8) (8), e1264-6 - E1266, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing.

  Tomoaki Fukui, Masaaki Ii, Taro Shoji, Tomoyuki Matsumoto, Yutaka Mifune, Yohei Kawakami, Hiroshi Akimaru, Atsuhiko Kawamoto, Tomoya Kuroda, Takashi Saito, Yasuhiko Tabata, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara

  May 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 27(5) (5), 1118 - 31, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of granulocyte colony-stimulating factor-mobilized human peripheral blood mononuclear cells for unhealing bone fractures.

  Tomoaki Fukui, Tomoyuki Matsumoto, Yutaka Mifune, Taro Shoji, Tomoya Kuroda, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Shin Kawamata, Masahiro Kurosaka, Takayuki Asahara, Ryosuke Kuroda

  2012, Cell transplantation, 21(4) (4), 707 - 21, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of ex vivo expanded bone marrow-derived CD34-positive cells accelerates fracture healing.

  Yohei Kawakami, Masaaki Ii, Cantas Alev, Atsuhiko Kawamoto, Tomoyuki Matsumoto, Ryosuke Kuroda, Taro Shoji, Tomoaki Fukui, Haruchika Masuda, Hiroshi Akimaru, Yutaka Mifune, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Masahiro Kurosaka, Takayuki Asahara

  2012, Cell transplantation, 21(12) (12), 2689 - 709, English, International magazine

  [Refereed]

  Scientific journal


• Therapeutic strategy of third-generation autologous chondrocyte implantation for osteoarthritis.

  Tomoya Kuroda, Tomoyuki Matsumoto, Yutaka Mifune, Tomoaki Fukui, Seiji Kubo, Takehiko Matsushita, Takayuki Asahara, Masahiro Kurosaka, Ryosuke Kuroda

  May 2011, Upsala journal of medical sciences, 116(2) (2), 107 - 14, English, International magazine

  [Refereed]

  Scientific journal


• Local transplantation of G-CSF-mobilized CD34(+) cells in a patient with tibial nonunion: a case report.

  Ryosuke Kuroda, Tomoyuki Matsumoto, Masahiko Miwa, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Yohei Kawakami, Takahiro Niikura, Sang Yang Lee, Keisuke Oe, Taro Shoji, Tomoya Kuroda, Miki Horii, Ayumi Yokoyama, Takayuki Ono, Yasushi Koibuchi, Shin Kawamata, Masanori Fukushima, Masahiro Kurosaka, Takayuki Asahara

  2011, Cell transplantation, 20(9) (9), 1491 - 6, English, International magazine

  [Refereed]

  Scientific journal


• Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.

  Tomoyuki Matsumoto, Masaaki Ii, Hiromi Nishimura, Taro Shoji, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, Tomoaki Fukui, Yohei Kawakami, Tomoya Kuroda, Sang Mo Kwon, Hiroto Iwasaki, Miki Horii, Ayumi Yokoyama, Akira Oyamada, Sang Yang Lee, Shinya Hayashi, Masahiro Kurosaka, Satoshi Takaki, Takayuki Asahara

  Sep. 2010, The Journal of experimental medicine, 207(10) (10), 2207 - 23, English, International magazine

  [Refereed]

  Scientific journal


• A palmar fracture-dislocation of the proximal interphalangeal joint of the middle finger caused by bowling: a case report.

  Tomoaki Fukui, Kazunari Ishida, Taro Shoji, Kenjiro Ito, Shinji Matsushima, Ryosuke Kuroda, Hiroyuki Fujioka, Masahiro Kurosaka, Kazuya Yoshida

  2009, Journal of sports science & medicine, 8(1) (1), 144 - 7, English, International magazine

  [Refereed]

  Scientific journal

• 【偽関節治療のエキスパートを目指そう】偽関節に対する新しい治療法 CD34陽性細胞移植とBMP(bone morphogenetic protein)

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Nov. 2023, 関節外科, 42(11) (11), 1295 - 1302, Japanese


• 3D造形βTCP人工骨の生体活性の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1718 - S1718, Japanese


• 異なる抗菌薬濃度により骨髄由来細胞が受ける影響の検討

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1723 - S1723, Japanese


• Masquelet法induced membrane由来細胞に対するLIPUSの骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 澤内 健一, 吉川 遼, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1747 - S1747, Japanese


• 廃用性骨萎縮・筋萎縮に対する炭酸ガス経皮吸収の予防効果

  西田 亮太, 大江 啓介, 福井 友章, 澤内 健一, 山本 裕也, 高瀬 恭平, 吉川 遼, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2023, 日本整形外科学会雑誌, 97(8) (8), S1749 - S1749, Japanese


• 【FRIの診断と治療-骨折手術後感染の疑問に答える】巨大骨欠損の再建 Masquelet法

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Jun. 2023, 臨床整形外科, 58(6) (6), 787 - 797, Japanese


• CLAP(1) 骨髄由来細胞に対する高濃度抗菌薬の影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S87 - S87, Japanese


• CLAP(1) 当院における慢性骨髄炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S90 - S90, Japanese


• 大腿骨骨欠損をMasquelet法で治療する際の移植骨局所担持のための工夫

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S239 - S239, Japanese


• LIPUSのMasquelet法induced membrane由来細胞に対する骨分化促進効果の検討

  高瀬 恭平, 福井 友章, 大江 啓介, 山本 裕也, 西田 亮太, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S243 - S243, Japanese


• がん骨転移に対する骨修飾薬使用歴が非定型大腿骨骨折の治療経過に与える影響に関する後ろ向き観察研究

  福井 友章, 大江 啓介, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S254 - S254, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S279 - S279, Japanese


• 大腿骨頸部骨折患者における骨粗鬆症治療薬介入とステム周囲骨密度変化率の関係について 多施設共同研究

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S340 - S340, Japanese


• 炭酸ガス経皮吸収と低出力超音波パルス療法(LIPUS)併用のラット大腿骨骨折治癒に対する効果

  西田 亮太, 澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 山本 裕也, 高瀬 恭平, 吉川 遼, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S368 - S368, Japanese


• Mycobacterium abscessus complex感染による骨髄炎・化膿性関節炎を持続局所抗菌薬灌流で治療した一例

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2023, 骨折, 45(Suppl.) (Suppl.), S474 - S474, Japanese


• 高濃度抗菌薬が骨髄由来細胞の増殖能および分化能に与える影響

  山本 裕也, 大江 啓介, 福井 友章, 澤内 健一, 吉川 遼, 高瀬 恭平, 西田 亮太, 新倉 隆宏, 圓尾 明弘, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 120 - 120, Japanese


• CLAPにおけるゲンタマイシンの血中濃度、排液中濃度と排液量の関係

  松宮 豊, 大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 121 - 121, Japanese


• 当院における化膿性関節炎に対する持続局所抗菌薬灌流療法(CLAP)の治療成績

  大江 啓介, 福井 友章, 澤内 健一, 松宮 豊, 新倉 隆宏, 黒田 良祐

  (一社)日本骨・関節感染症学会, Jun. 2023, 日本骨・関節感染症学会プログラム・抄録集, 46回, 131 - 131, Japanese


• 超音波治療の世界(基礎と臨床) LIPUSによる骨折治癒促進

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本超音波医学会, Apr. 2023, 超音波医学, 50(Suppl.) (Suppl.), S376 - S376, Japanese


• メッシュプレートを用いて内固定を行った母趾基節骨偽関節の2例

  大野 裕也, 福井 友章, 大江 啓介, 澤内 健一, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(春季学会) (春季学会), 289 - 289, Japanese


• 骨SPECT/CTにおける偽関節モデルファントムを用いた金属インプラントのCT減弱補正に関する研究

  大江 啓介, 福井 友章, 澤内 健一, 新倉 隆宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1024 - S1024, Japanese


• ここまできた!骨・軟骨再生医療の最前線 偽関節患者に対する自家末梢血CD34陽性細胞移植による骨・血管再生医療

  大江 啓介, 新倉 隆宏, 福井 友章, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1072 - S1072, Japanese


• 四肢長管骨偽関節患者を対象としたBMP-2・人工骨複合体の第I/II相治験の結果

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 患者立脚型QOL評価を用いた大腿骨および脛骨偽関節の術後成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2023, 日本整形外科学会雑誌, 97(3) (3), S1082 - S1082, Japanese


• 脛骨慢性骨髄炎病的骨折に対しCLAPを併用し骨接合術と遊離皮弁術を同時に行った1例

  牟田口 由紀子, 澤内 健一, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2023, 中部日本整形外科災害外科学会雑誌, 66(2) (2), 334 - 335, Japanese


• 骨形成不全症患者に生じた非定型大腿骨骨折の1例

  上出 將志, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 146 - 146, Japanese


• 大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 黒田 良祐, 酒井 良忠

  (一社)中部日本整形外科災害外科学会, Apr. 2022, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 158 - 158, Japanese


• 偽関節治療の基礎研究と臨床応用

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S39 - S39, Japanese


• 非定型大腿骨骨折の病態と治療 非定型大腿骨骨折の病態と疫学

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S469 - S469, Japanese


• 小児整形外科疾患に対する新しい治療法-その展望および問題点- 先天性下腿偽関節症に対するMasquelet法を用いた治療経験

  坂田 亮介, 新倉 隆宏, 薩摩 眞一, 小林 大介, 衣笠 真紀, 八尋 俊輔, 北澤 大也, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(2) (2), S508 - S508, Japanese


• 高齢大腿骨頸部骨折患者の髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究

  大江 啓介, 新倉 隆宏, 福井 友章, 林 申也, 酒井 良忠, 高原 俊介, 岩倉 崇, 角田 雅也, 柴原 克紀, 正田 悦朗, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, Japanese


• 患者立脚型機能評価を用いた上肢偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S839 - S839, Japanese


• CT有限要素法を用いたreamer irrigator aspirator施行前後の大腿骨強度変化についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 長宗 高樹, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S878 - S878, Japanese


• 難治性骨折に対する自家CD34陽節細胞移植 医師主導治験の成果報告

  新倉 隆宏, 大江 啓介, 福井 友章, 松本 知之, 美舩 泰, 川本 篤彦, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2022, 日本整形外科学会雑誌, 96(3) (3), S1027 - S1027, Japanese


• KLF15を介した筋萎縮の分子機構の解明

  平田悠, 野村和弘, 加藤大輔, 橘吉寿, 新倉隆宏, 内山奏, 細岡哲也, 細岡哲也, 福井友章, 大江啓介, 黒田良祐, 原雄二, 安達貴弘, 柴崎貢志, 和氣弘明, 小川渉

  2022, 糖尿病(Web), 65(Suppl) (Suppl)


• Quantitative evaluation of bone SPECT for uninfected nonunion

  曽菲比, 大江啓介, 野上宗伸, 犬養純子, 立花美保, 久保和広, 福井友章, 新倉隆宏, 黒田良祐, 村上卓道

  2021, 核医学(Web), 58(Supplement) (Supplement)


• 非感染性偽関節に対する骨SPECTの定量評価(Quantitative evaluation of bone SPECT for uninfected nonunion)

  曽 菲比, 大江 啓介, 野上 宗伸, 犬養 純子, 立花 美保, 久保 和広, 福井 友章, 新倉 隆宏, 黒田 良祐, 村上 卓道

  (一社)日本核医学会, 2021, 核医学, 58(Suppl.) (Suppl.), S198 - S198, English


• 偽関節-どうしてこうなったか,なったらどうするか-

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 15 - 15, Japanese


• 膀胱癌手術後に両下腿のwell leg compartment syndrome(WLCS)を生じた一例

  名古竜平, 大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  (一社)中部日本整形外科災害外科学会, 2021, 中部日本整形外科災害外科学会雑誌, 64(春季学会) (春季学会), 135 - 135, Japanese


• Clinically applicable regeneration therapy: Transplantation of autologous peripheral blood CD34-positive cells to fracture nonunion patients

  新倉隆宏, 松本知之, 美舩泰, 福井友章, 大江啓介, 黒田良祐

  (一社)日本再生医療学会, 2021, 再生医療, 20(1) (1), 50 - 55, Japanese


• 上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例

  松宮 豊, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 157 - 157, Japanese


• 上腕骨インプラント周囲骨折後にballooning変形を起こした偽関節の1例

  松宮 豊, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Oct. 2020, 中部日本整形外科災害外科学会雑誌, 63(秋季学会) (秋季学会), 157 - 157, Japanese


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, Japanese


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese


• 下肢難治性骨折に対する細胞治療

  黒田 良祐, 新倉 隆宏, 福井 友章, 大江 啓介, 松本 知之

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S36 - S36, Japanese


• 骨折に対する積極的保存療法(臨床編)第1部 LIPUS照射部位ターゲティング

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S40 - S40, Japanese


• 骨転移症例に対する骨折治療戦略 骨修飾薬使用中の癌骨転移患者に発生した非定型大腿骨骨折についての多施設共同研究

  福井 友章, 新倉 隆宏, 大江 啓介, 高原 俊介, 櫻井 敦志, 岩倉 崇, 吉田 圭二, 伊藤 研二郎, 正田 悦朗, 北田 真平, 平中 崇文, 角田 雅也, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S70 - S70, Japanese


• Masquelet法におけるinduced membraneのMRI評価についての検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneの患者検体を用いた組織学的検討

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S121 - S121, Japanese


• Masquelet法におけるinduced membraneはpseudo-synovial membraneか?

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S122 - S122, Japanese


• 大腿骨転子部骨折におけるshort femoral nailの髄内挙動 模擬骨を用いた力学試験

  高原 俊介, 長宗 高樹, 大江 啓介, 野田 光昭, 市村 克仁, 西原 寛玄, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S129 - S129, Japanese


• 1型糖尿病ラット骨折モデルにおける炭酸ガス経皮吸収による骨折治癒促進効果の検討

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S146 - S146, Japanese


• 偽関節における骨SPECTを用いた定量評価の試み

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2020, 骨折, 42(Suppl.) (Suppl.), S366 - S366, Japanese


• 卵巣摘出ラット骨粗鬆症モデルにおける炭酸ガス経皮吸収による骨粗鬆症改善効果の検討

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1684 - S1684, Japanese


• Reamer irrigator aspirator(RIA)産物から得た細胞の骨分化に対するlow-intensity pulsed ultrasound(LIPUS)の効果

  澤内 健一, 新倉 隆宏, 福井 友章, 大江 啓介, 吉川 遼, 小田 崇弘, 隈部 洋平, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1685 - S1685, Japanese


• ウサギを用いた222nm紫外線術野照射の安全性の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1713 - S1713, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおける骨折治癒を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 隈部 洋平, 澤内 健一, 吉川 遼, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1802 - S1802, Japanese


• 骨折治癒過程を超音波の周波数特性により推定する試み

  大江 啓介, 隈部 洋平, 新倉 隆宏, 福井 友章, 黒田 良祐, 畑 豊, 森本 雅和, 八木 直美, 小矢 美晴

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1918 - S1918, Japanese


• 男性骨粗鬆症モデルラットに対する炭酸ガス経皮吸収の影響に関する検討

  吉川 遼, 新倉 隆宏, 福井 友章, 大江 啓介, 澤内 健一, 小田 崇弘, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2020, 日本整形外科学会雑誌, 94(8) (8), S1956 - S1956, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  (一社)日本内分泌学会, Aug. 2020, 日本内分泌学会雑誌, 96(1) (1), 248 - 248, Japanese


• 高齢者肘関節脱臼に対してテープ付きアンカーを用いた靱帯修復を行なった一例

  元野 紘平, 乾 淳幸, 美舩 泰, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 206 - 206, Japanese


• 髄内釘のコンプレッション機構を利用し、自家骨移植なしで治療した上腕骨骨幹部偽関節の一例

  福本 弦太, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2020, 中部日本整形外科災害外科学会雑誌, 63(春季学会) (春季学会), 271 - 271, Japanese


• 不動化はCa2+シグナルの減弱を通じて筋萎縮を制御する

  平田 悠, 野村 和弘, 新倉 隆宏, 橘 吉寿, 加藤 大輔, 内山 奏, 福井 友章, 大江 啓介, 細岡 哲也, 和氣 弘明, 黒田 良祐, 小川 渉

  日本臨床分子医学会, Apr. 2020, 日本臨床分子医学会学術総会プログラム・抄録集, 57回, 58 - 58, Japanese


• 【整形外科の外傷治療-現状と課題-】その他のトピックにおける現状と課題 骨折治癒促進を目指した,臨床へとつなげる基礎研究

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)メジカルビュー社, Apr. 2020, 関節外科, 39(4月増刊) (4月増刊), 145 - 150, Japanese


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果

  隈部 洋平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  日本創外固定・骨延長学会, Mar. 2020, 日本創外固定・骨延長学会雑誌, 31, 352 - 352, Japanese


• 健常人における222 nmUVC照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(2) (2), S160 - S160, Japanese


• DBMを利用した骨欠損や偽関節の治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S579 - S579, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 櫻井 敦志, 岩倉 崇

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S904 - S904, Japanese


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験とRIAリーマー径についての検討

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S949 - S949, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる 臨床試験の報告

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 秋末 敏宏, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2020, 日本整形外科学会雑誌, 94(3) (3), S1040 - S1040, Japanese


• Intra-medullary distribution of antibiotics by intra-medullary antibiotics perfusion(iMAP)-A cadaver study-

  圓尾明弘, 福井友章, 大江啓介, 新倉隆宏, 善家雄吉

  2020, 骨折(Web), 42(1) (1)


• Intra-medullary nail motion in the fixation for trochanteric femoral fracture with short femoral nail; Biomechanical analysis in Sawbones.

  高原俊介, 長宗高樹, 大江啓介, 野田光昭, 市村克仁, 西原寛玄, 福井友章, 新倉隆宏, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Targeting of low-intensity pulsed ultrasound treatment

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Multicenter study on atypical femoral fractures in patients with bone metastases using bone modifying agents

  福井友章, 新倉隆宏, 大江啓介, 高原俊介, 櫻井敦志, 岩倉崇, 吉田圭二, 伊藤研二郎, 正田悦朗, 北田真平, 平中崇文, 角田雅也, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Investigation of the effect of topical cutaneous CO2 application on fracture healing in streptozotocin-induced diabetic rats

  小田崇弘, 新倉隆宏, 福井友章, 大江啓介, 吉川遼, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Assessment of induced membrane formation by magnetic resonance imaging in Masquelet reconstruction surgery

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Cell therapy for patients with femoral and tibial Nonunion

  黒田良祐, 新倉隆宏, 福井友章, 大江啓介, 松本知之

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Quantitative Bone SPECT imaging for non union

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• Is the Masquelet induced membrane a pseudo-synovial membrane?

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2020, 骨折(Web), 42(Supplement) (Supplement)


• 超音波画像を用いた骨癒合の評価

  清水風, 小矢美晴, 大江啓介, 隈部洋平, 福井友章, 新倉隆宏

  2020, 電気関係学会関西連合大会(Web), 2020


• Intra-medullary antibiotics perfusion(iMAP)から屍体脛骨髄内に投与された抗菌薬の薬物動態

  圓尾 明弘, 福井 友章, 大江 啓介, 新倉 隆宏, 善家 雄吉

  (一社)日本骨折治療学会, Jan. 2020, 骨折, 42(1) (1), 1 - 5, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本肥満学会, Oct. 2019, 肥満研究, 25(Suppl.) (Suppl.), 260 - 260, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田崇弘, 新倉隆宏, 福井友章, 大江啓介, 新倉路生, 黒岩祐, 隈部洋平, 澤内健一, 酒井良忠, 黒田良祐

  (公社)日本整形外科学会, 09 Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  澤内健一, 平田悠, 野村和弘, 小田崇弘, 福井友章, 大江啓介, 新倉隆宏, 黒田良祐, 小川渉

  (公社)日本整形外科学会, 09 Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1749 - S1749, Japanese


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部洋平, 新倉隆宏, 福井友章, 高原俊介, 黒岩祐, 新倉路生, 大江啓介, 小田崇弘, 澤内健一, 黒田良祐

  (公社)日本整形外科学会, 09 Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese


• 低左心機能を伴う不整脈源性右室心筋症の心不全治療に苦慮した一例

  鍵本 美奈子, 木野 旅人, 田口 有香, 清國 雅義, 細田 順也, 松本 克己, 菅野 晃靖, 石上 友章, 福井 和樹, 石川 利之, 木村 一雄, 田村 功一

  (一社)日本心臓病学会, Sep. 2019, 日本心臓病学会学術集会抄録, 67回, O - 142, Japanese


• 自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例

  中川 大輔, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部 洋平, 新倉 隆宏, 福井 友章, 高原 俊介, 黒岩 祐, 新倉 路生, 大江 啓介, 小田 崇弘, 澤内 健一, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1622 - S1622, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  澤内 健一, 平田 悠, 野村 和弘, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 小川 渉

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1749 - S1749, Japanese


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 新倉 路生, 黒岩 祐, 隈部 洋平, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Sep. 2019, 日本整形外科学会雑誌, 93(8) (8), S1755 - S1755, Japanese


• 腫瘍性骨軟化症による大腿骨頸部病的骨折をきたした1例

  井上 悠, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 958 - 958, Japanese


• 非定型大腿骨骨折術後偽関節の治療経験

  新倉 隆宏, 西本 華子, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨粗鬆症学会, Sep. 2019, 日本骨粗鬆症学会雑誌, 5(Suppl.1) (Suppl.1), 457 - 457, Japanese


• 自己免疫性多内分泌腺症候群2型による続発性骨軟化症にて両側脛骨近位端骨折を生じた1例

  中川大輔, 大江啓介, 福井友章, 新倉隆宏, 黒田良祐

  (一社)中部日本整形外科災害外科学会, 01 Sep. 2019, 中部日本整形外科災害外科学会雑誌, 62(秋季学会) (秋季学会), 109 - 109, Japanese


• 骨欠損部へのヒトiPS細胞移植 軟骨内骨化を介した骨再生の試み

  李 相亮, 新倉 路生, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S100 - S100, Japanese


• 解剖用屍体におけるiMAPから髄内に投与された抗菌薬の薬物動態の検討

  圓尾 明弘, 福井 友章, 大江 啓介, 新倉 隆宏, 善家 雄吉

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S101 - S101, Japanese


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese


• 骨欠損部へのヒトiPS細胞移植 軟骨内骨化を介した骨再生の試み

  李 相亮, 新倉 路生, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S100 - S100, Japanese


• 解剖用屍体におけるiMAPから髄内に投与された抗菌薬の薬物動態の検討

  圓尾 明弘, 福井 友章, 大江 啓介, 新倉 隆宏, 善家 雄吉

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S101 - S101, Japanese


• Masquelet法で治療した患者におけるinduced membraneの組織学的評価

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S167 - S167, Japanese


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S170 - S170, Japanese


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S378 - S378, Japanese


• 大腿骨頸部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 黒田 良祐, 岩倉 崇, 櫻井 敦志

  (一社)日本骨折治療学会, Jun. 2019, 骨折, 41(Suppl.) (Suppl.), S420 - S420, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  日本臨床分子医学会, Apr. 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 56回, 71 - 71, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 千賀 陽子, 岡田 裕子, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  日本臨床分子医学会, Apr. 2019, 日本臨床分子医学会学術総会プログラム・抄録集, 56回, 71 - 71, Japanese


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 千賀 陽子, 岡田 裕子, 小林 憲太, 岡本 士毅, 箕越 靖彦, 今村 道博, 武田 伸一, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  (一社)日本糖尿病学会, Apr. 2019, 糖尿病, 62(Suppl.1) (Suppl.1), S - 149, Japanese


• 整形外傷領域における再生医療

  新倉隆宏, 松本知之, 美舩泰, 福井友章, 大江啓介, 黒田良祐

  (公社)日本整形外科学会, 05 Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(2) (2), S113 - S113, Japanese


• 坐骨結節裂離骨折偽関節に対し手術加療を行った1例

  中松裕太, 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2019, 中部日本整形外科災害外科学会雑誌, 62(春季学会) (春季学会), 200 - 200, Japanese


• 患者立脚型機能評価による大腿骨・脛骨偽関節の治療成績の検討

  福井友章, 新倉隆宏, 岩倉崇, 李相亮, 李相亮, 大江啓介, 黒田良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S963 - S963, Japanese


• Reamer irrigator aspirator(RIA)を日本人患者に使用した臨床経験

  新倉隆宏, 大江啓介, 福井友章, 工藤健史, 黒田良祐

  (公社)日本整形外科学会, Mar. 2019, 日本整形外科学会雑誌, 93(3) (3), S965 - S965, Japanese


• ウサギ骨延長術モデルにおける炭酸ガス経皮吸収の骨形成促進効果について

  隈部洋平, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2019, 移植(Web), 54(4-5) (4-5)


• Surgical treatment with locking plate for lower limb nonunion

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Pharmacokinetics of intramedullary administrated antibiotics infused from iMAP at Cadaver

  圓尾明弘, 福井友章, 大江啓介, 新倉隆宏, 善家雄吉

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Histological analysis of the induced membrane of the patients whose bone defects were treated by the Masquelet technique

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Investigation of postoperative CT image evaluation method of femoral neck fracture

  大江啓介, 新倉隆宏, 福井友章, 黒田良祐, 岩倉崇, 櫻井敦志

  2019, 骨折(Web), 41(Supplement) (Supplement)


• Effect of explanation with document for improvement of patient compliance for low-intensity pulsed ultrasound (LIPUS) treatment

  福井友章, 新倉隆宏, 大江啓介, 黒田良祐

  2019, 骨折(Web), 41(Supplement) (Supplement)


• 体外衝撃波療法は閉経後の骨粗鬆症を改善する

  井上翔太, 脇本祥夫, 李昌欣, 畠山隼平, 新倉隆宏, 大江啓介, 福井友章, 黒木裕士, 森山英樹

  (一社)日本理学療法学会連合, 2019, 日本基礎理学療法学会学術大会プログラム・抄録集(Web), 24th(Suppl.1) (Suppl.1), 159 - 159, Japanese


• 文書を用いた説明による超音波骨折治療器使用における患者コンプライアンス向上の試み

  福井友章, 大江啓介, 新倉隆宏, 黒田良祐

  2019, 超音波骨折治療研究会プログラム・抄録集, 22nd, 30(JA),30‐31(EN), Japanese


• ヒトiPS細胞による軟骨内骨化を介した骨再生の試み

  李相亮, 李相亮, 新倉路生, 福井友章, 黒田良祐, 新倉隆宏

  2019, 日本再生医療学会総会(Web), 18th, ROMBUNNO.P‐03‐067 (WEB ONLY), Japanese


• RIA産物と人工骨の混合移植による骨欠損の再建

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  25 Dec. 2018, 臨床整形外科, 53(12) (12), 1087‐1093, Japanese


• 外傷における人工骨の臨床 RIA産物と人工骨の混合移植による骨欠損の再建

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (株)医学書院, Dec. 2018, 臨床整形外科, 53(12) (12), 1087 - 1093, Japanese


• 技術革新に伴うマイクロサージャリーの適応変化 Masquelet法とReamer Irrigator Aspiratorを用いた骨欠損・難治骨折の治療

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  (一社)日本マイクロサージャリー学会, Dec. 2018, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 45回, 128 - 128, Japanese


• Reconstruction of Bone Defect by Combined Graft of Reamer Irrigator Aspirator Product and Synthetic Bone

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  医学書院, Dec. 2018, 臨床整形外科, 53(12) (12), 1087 - 1093, Japanese


• 骨粗鬆症診療の真の目的は何か?!―脆弱性骨折の予防と診療の最前線 脆弱性骨折の連鎖―ケーススタディから学ぶ―

  新倉隆宏, 岩倉崇, 大江啓介, 林申也, 福井友章, 西本華子, 黒田良祐

  (株)ライフメディコム, Oct. 2018, カレントテラピー, 36(10) (10), 970 - 979, Japanese


• 同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例

  大澤 慎, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李 相亮, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese


• 同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例

  大澤慎, 大江啓介, 福井友章, 新倉隆宏, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 292 - 292, Japanese


• 広範切除から14年後に再発を認めた脛骨Adamantinomaの一例

  瀧上俊作, 福井友章, 河本旭哉, 戸祭正喜, 新倉隆宏, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2018, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 118 - 118, Japanese


• 下肢偽関節手術後に低出力超音波パルスを使用した症例についての検討

  LEE S. Y, LEE S. Y, 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  (一社)日本骨折治療学会, Sep. 2018, 骨折, 40(4) (4), 1107 - 1110, Japanese


• 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江啓介, 新倉隆宏, 福井友章, 黒岩祐, 隈部洋平, 小田崇弘, 澤内健一, 酒井良忠, 黒田良祐

  30 Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1877, Japanese


• ラット骨欠損モデルにおけるCO₂経皮吸収の骨形成促進作用についての検討

  黒岩祐, 新倉隆宏, 高原俊介, 高原俊介, 李相亮, 李相亮, 大江啓介, 福井友章, 新倉路生, 隈部洋平, 小田崇弘, 酒井良忠, 黒田良祐

  30 Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1998, Japanese


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese


• ヒトiPS細胞による軟骨内骨化を介した骨再生療法

  新倉 路生, 李 相亮, 福井 友章, 大江 啓介, 高原 俊介, 黒岩 祐, 隈部 洋平, 黒田 良祐, 新倉 隆宏

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, Japanese


• 組織再生における血管新生 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江 啓介, 新倉 隆宏, 福井 友章, 黒岩 祐, 隈部 洋平, 小田 崇弘, 澤内 健一, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1877 - S1877, Japanese


• ラット骨欠損モデルにおけるCO2経皮吸収の骨形成促進作用についての検討

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 福井 友章, 新倉 路生, 隈部 洋平, 小田 崇弘, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1998 - S1998, Japanese


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井友章, 新倉隆宏, 小田崇弘, 隈部洋平, 大江啓介, 黒田良祐

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1757 - S1757, Japanese


• ヒトiPS細胞による軟骨内骨化を介した骨再生療法

  新倉路生, 李相亮, 李相亮, 福井友章, 大江啓介, 高原俊介, 黒岩祐, 隈部洋平, 黒田良祐, 新倉隆宏

  (公社)日本整形外科学会, Aug. 2018, 日本整形外科学会雑誌, 92(8) (8), S1988 - S1988, Japanese


• 患者立脚型機能評価を用いた下肢偽関節治療成績

  福井 友章, 大江 啓介, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S208 - S208, Japanese


• 日本人におけるReamer irrigator aspirator:(RIA)の使用経験

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S450 - S450, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李 相亮, 大江 啓介, 福井 友章, 乾 淳幸, 黒田 良祐, 新倉 隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese


• 日本人におけるReamer irrigator aspirator(RIA)の使用経験

  大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S450 - S450, Japanese


• 患者立脚型機能評価を用いた下肢偽関節治療成績

  福井友章, 大江啓介, 黒田良祐, 新倉隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S208 - S208, Japanese


• 222nm紫外線照射の安全性および殺菌効果

  福井友章, 新倉隆宏, 小田崇弘, 隈部洋平, 大江啓介, 黒田良祐

  日本骨・関節感染症学会, Jul. 2018, 日本骨・関節感染症学会プログラム・抄録集, 41回, 135 - 135, Japanese


• 若年成人に発生した非定型大腿骨骨折の3例

  李相亮, 李相亮, 大江啓介, 福井友章, 乾淳幸, 黒田良祐, 新倉隆宏

  (一社)日本骨折治療学会, Jul. 2018, 骨折, 40(Suppl.) (Suppl.), S495 - S495, Japanese


• 上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例

  栖田 慶仁, 大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  中部日本整形外科災害外科学会, May 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese


• 上腕骨骨幹部骨折術後偽関節に対してMIPO法にて治療した2例

  栖田慶仁, 大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  (一社)中部日本整形外科災害外科学会, May 2018, 中部日本整形外科災害外科学会雑誌, 61(3) (3), 613 - 613, Japanese


• インプラント周囲での非定型大腿骨骨折の1例

  田中秀弥, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Mar. 2018, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 114 - 114, Japanese


• 患者立脚型機能評価を含めた下肢偽関節治療経過の検討

  福井友章, 岩倉崇, 李相亮, 大江啓介, 黒田良祐, 新倉隆宏

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(2) (2), S86 - S86, Japanese


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (公社)日本整形外科学会, Mar. 2018, 日本整形外科学会雑誌, 92(3) (3), S1238 - S1238, Japanese


• CO2経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる

  小田 崇弘, 黒岩 祐, 高原 俊介, 新倉 路生, 隈部 洋平, 李 相亮, 大江 啓介, 岩倉 崇, 福井 友章, 酒井 良忠, 新倉 隆宏, 黒田 良祐

  (一社)日本移植学会, Feb. 2018, 移植, 52(6) (6), 581 - 581, Japanese


• Masquelet法とReamer Irrigator Aspiratorを用いた骨欠損・難治骨折の治療

  新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  2018, 日本マイクロサージャリー学会学術集会プログラム・抄録集, 45th, 128, Japanese


• 超音波骨折治療におけるコンプライアンス向上のための試み(第2報)

  大江啓介, 福井友章, 黒田良祐, 新倉隆宏

  2018, 超音波骨折治療研究会プログラム・抄録集, 21st, 48(JA),48‐49(EN), Japanese


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果について

  隈部洋平, 新倉隆宏, 福井友章, 大江啓介, 高原俊介, 新倉路生, 黒岩祐, 小田崇弘, 黒田良祐

  2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.P‐03‐076 (WEB ONLY), Japanese


• 難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法―医師主導治験の経験から―

  黒田良祐, 大江啓介, 福井友章, 新倉隆宏, 松本知之

  2018, 日本再生医療学会総会(Web), 17th, ROMBUNNO.SY‐35‐5 (WEB ONLY), Japanese


• 骨形成不全症に合併した上腕骨骨幹部偽関節に対して下顎骨用locking plateを用いて治療した1例

  佐野翔平, 新倉隆宏, 大江啓介, 福井友章, 黒田良祐

  (一社)中部日本整形外科災害外科学会, Sep. 2017, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 193 - 193, Japanese


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  新倉隆宏, 大江啓介, 岩倉崇, 李相亮, 福井友章, 櫻井敦志, 酒井良忠, 黒田良祐

  (一社)日本骨粗鬆症学会, Sep. 2017, 日本骨粗鬆症学会雑誌, 3(Suppl.1) (Suppl.1), 283 - 283, Japanese


• CO₂経皮吸収はラット骨欠損モデルにおける骨形成を促進させる

  黒岩祐, 新倉隆宏, 高原俊介, 李相亮, 大江啓介, 岩倉崇, 福井友章, 新倉路生, 隈部洋平, 酒井良忠, 黒田良祐

  (公社)日本整形外科学会, 31 Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1481 - S1481, Japanese


• 骨折治癒過程におけるmicroRNAの発現:糖尿病・健常ラツト間の比較検討

  高原俊介, 李相亮, 新倉隆宏, 大江啓介, 福井友章, 新倉路生, 黒岩祐, 隈部洋平, 酒井良忠, 黒田良祐

  (公社)日本整形外科学会, 31 Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1640 - S1640, Japanese


• 骨再生と骨癒合促進 CO2経皮吸収はラット骨欠損モデルにおける骨形成を促進させる

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 岩倉 崇, 福井 友章, 新倉 路生, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1481 - S1481, Japanese


• 骨折治癒過程におけるmicroRNAの発現 糖尿病・健常ラット間の比較検討

  高原 俊介, 李 相亮, 新倉 隆宏, 大江 啓介, 福井 友章, 新倉 路生, 黒岩 祐, 隈部 洋平, 酒井 良忠, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1640 - S1640, Japanese


• 大腸菌由来BMP‐2含有β‐TCP顆粒はウサギ大腿骨骨欠損の骨形成を促進する

  新倉路生, 新倉隆宏, 李相亮, 岩倉崇, 福井友章, 高原俊介, 黒岩祐, 隈部洋平, 酒井良忠, 黒田良祐

  (公社)日本整形外科学会, Aug. 2017, 日本整形外科学会雑誌, 91(8) (8), S1493 - S1493, Japanese


• PTH間歇投与はラット難治性骨折モデルにおける骨癒合を促進させる

  李相亮, 脇貴洋, 岩倉崇, 高原俊介, 新倉路生, 福井友章, 黒田良祐, 新倉隆宏

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S269 - S269, Japanese


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる―臨床試験の報告―

  新倉隆宏, 岩倉崇, 李相亮, 大江啓介, 福井友章, 酒井良忠, 黒田良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S74 - S74, Japanese


• 偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李相亮, 新倉隆宏, 福井友章, 大江啓介, 黒田良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S295 - S295, Japanese


• 大腿骨近位部骨折に対する髄内釘固定後の折損例の検討

  福井友章, 新倉隆宏, 李相亮, 黒田良祐

  (一社)日本骨折治療学会, Jul. 2017, 骨折, 39(Suppl.) (Suppl.), S198 - S198, Japanese


• ゾレドロン酸・デノスマブ投与中のがん患者に発生した非定型大腿骨骨折についての検討

  福井 友章, 李 相亮, 新倉 隆宏, 岩倉 崇, 櫻井 敦志, 黒田 良祐

  (一社)中部日本整形外科災害外科学会, Apr. 2017, 中部日本整形外科災害外科学会雑誌, 60(春季学会) (春季学会), 157 - 157, Japanese


• 骨粗鬆症性椎体骨折地域連携パス導入による効果―治療継続率の向上と骨折連鎖の予防を目指して―

  原田俊彦, 岸本健太, 高山博行, 青木謙二, 西原寛玄, 市村克仁, 福井友章, 中川夏子, 上藤淳郎

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(2) (2), S621 - S621, Japanese


• プロサッカー選手におけるハムストリング肉離れからの復帰時期

  福井友章, 原田俊彦, 松下雄彦, 柳田博美, 黒田良祐

  (公社)日本整形外科学会, Mar. 2017, 日本整形外科学会雑誌, 91(3) (3), S703 - S703, Japanese


• 非定型大腿骨骨折に対する低出力超音波パルスの使用経験

  LEE Sang Yang, 新倉隆宏, 岩倉崇, 福井友章, 黒田良祐

  2017, 超音波骨折治療研究会プログラム・抄録集, 20th, 24, Japanese


• CO₂経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる

  小田崇弘, 黒岩祐, 高原俊介, 新倉路生, 隈部洋平, 李相亮, 大江啓介, 岩倉崇, 福井友章, 酒井良忠, 新倉隆宏, 黒田良祐

  2017, 移植(Web), 52(6) (6), 581(J‐STAGE), Japanese


• リウマチ患者における骨粗鬆症治療の現状

  上藤淳郎, 中川夏子, 原田俊彦, 高山博行, 青木謙二, 岸本健太, 西原寛玄, 市村克仁, 福井友章

  (一社)日本関節病学会, Oct. 2016, 日本関節病学会誌, 35(3) (3), 397 - 397, Japanese


• 当センターにおける大腿骨近位部骨折患者の骨粗鬆症治療薬継続率

  岸本健太, 原田俊彦, 中川夏子, 高山博行, 青木謙二, 西原寛玄, 市村克仁, 福井友章, 上藤淳郎, 谷口光子

  (一社)日本骨粗鬆症学会, Sep. 2016, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 244 - 244, Japanese


• 骨癒合促進の最前線 自家末梢血CD34陽性細胞による難治性骨折の治療

  松本知之, 新倉隆宏, 美舩泰, 福井友章, 川上洋平, 黒田良祐

  金原出版(株), May 2016, 整形・災害外科, 59(5) (5), 557 - 565, Japanese


• Autologous transplantation of peripheral blood CD34-positive cells for patients with fracture nonunion

  松本 知之, 新倉 隆宏, 美舩 泰, 福井 友章, 川上 洋平, 黒田 良祐

  金原出版, May 2016, 整形・災害外科, 59(5) (5), 557 - 565, Japanese


• 多椎間狭窄の頚椎症性脊髄症に対する棘突起縦割式椎弓形成術と選択的椎弓切除術の前向きランダム化比較

  市村克仁, 高山博行, 原田俊彦, 青木謙二, 岸本健太, 西原寛玄, 福井友章

  (公社)日本整形外科学会, 04 Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S217 - S217, Japanese


• 多椎間狭窄の頸椎症性脊髄症に対する棘突起縦割式椎弓形成術と選択的椎弓切除術の前向きランダム化比較

  市村 克仁, 高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 福井 友章

  (公社)日本整形外科学会, Mar. 2016, 日本整形外科学会雑誌, 90(2) (2), S217 - S217, Japanese


• 腰部脊柱管狭窄症の手術成績に糖尿病が及ぼす影響について

  高山博行, 原田俊彦, 青木謙二, 岸本健太, 西原寛玄, 市村克仁, 福井友章

  (一社)日本脊椎脊髄病学会, Mar. 2016, Journal of Spine Research, 7(3) (3), 338 - 338, Japanese


• 先行需要情報がミズナ栽培の収益に与える影響及びリスク分析についての研究

  福井友章, 宮坂寿郎, 清水浩, 中嶋洋, 大土井克明

  2016, システム農学会シンポジウム要旨集, 2016, 17‐18, Japanese


• 身心一体科学からの生活・健康の見直し 1日10分の立位着地の意味

  跡見 綾, 伊藤 恵莉子, 福井 淳, 茂内 将希, 栗本 大嗣, 跡見 友章, 藤田 恵理, 清水 美穂, 跡見 順子

  (一社)日本体力医学会, Dec. 2015, 体力科学, 64(6) (6), 698 - 698, Japanese


• プロサッカー選手における脛骨疲労骨折に対する治療経験

  福井友章, 原田俊彦, 柳田博美, 角田雅也

  (一社)日本臨床スポーツ医学会, Oct. 2015, 日本臨床スポーツ医学会誌, 23(4) (4), S194 - S194, Japanese


• 骨粗鬆症・脊椎椎体骨折地域連携パス―導入の背景と今後の展望―

  高山博行, 原田俊彦, 青木謙二, 岸本健太, 西原寛玄, 市村克仁, 福井友章, 谷口光子

  (一社)日本クリニカルパス学会, Oct. 2015, 日本クリニカルパス学会誌, 17(4) (4), 594 - 594, Japanese


• 自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本知之, 新倉隆宏, 川上洋平, 福井友章, 美舩泰, LEE Sang Yang, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  30 Jan. 2015, 日本整形外科学会雑誌, 89(1) (1), 26 - 32, Japanese


• 骨関節の再生医療の現状と展望 自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  (公社)日本整形外科学会, Jan. 2015, 日本整形外科学会雑誌, 89(1) (1), 26 - 32, Japanese


• 自分でやってみて評価し言語化することを通じて自分を知る未病教育

  清水 美穂, 藤田 恵理, 跡見 綾, 佐野 将英, 伊藤 恵莉子, 早崎 沙彩, 栗本 大嗣, 茂内 将司, 福井 淳, 渡邊 敏行, 跡見 友章, 廣瀬 昇, 田中 和哉, 長谷川 克也, 畠山 望, 小川 清貴, 山口 耕平, 酒井 元気, 伊勢 勤子, 跡見 順子

  (一社)日本未病学会, Oct. 2014, 日本未病システム学会学術総会抄録集, 21回, 111 - 111, Japanese


• 未病シャペロン(αBクリスタリン)に着目した短時間の着地刺激が抗重力筋の萎縮軽減に及ぼす影響について

  跡見 綾, 伊藤 恵莉子, 福井 淳, 茂内 将希, 栗本 大嗣, 佐野 将英, 跡見 友章, 藤田 恵理, 清水 美穂, 小城 勝相, 跡見 順子

  (一社)日本未病学会, Oct. 2014, 日本未病システム学会学術総会抄録集, 21回, 137 - 137, Japanese


• 多発外傷を伴う骨盤輪骨折の治療成績

  西原寛玄, 福井友章, 岸本健太, 青木謙二, 高山博行, 原田俊彦

  (一社)日本骨折治療学会, Jun. 2014, 骨折, 36(3) (3), 584 - 587, Japanese


• 偽関節患者を対象とした,自家末梢血CD34陽性細胞を用いた骨・血管再生療法

  松本知之, 新倉隆宏, 川上洋平, 福井友章, 美舩泰, 李相亮, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  27 Jan. 2014, 再生医療, 13, 139, Japanese


• 脊椎ナビゲーションシステムを用いた仙腸関節経皮的スクリュー固定の経験

  赤羽志保, 西原寛玄, 原田俊彦, 高山博行, 青木謙二, 岸本健太, 福井友章

  日本最小侵襲整形外科学会, Oct. 2013, 日本最小侵襲整形外科学会誌(CD-ROM), 13(1) (1), 153 - 153, Japanese


• 当院におけるMIS‐TKA使用経験

  西原寛玄, 福井友章, 岸本健太, 青木謙二, 高山博行, 原田俊彦

  日本最小侵襲整形外科学会, Oct. 2013, 日本最小侵襲整形外科学会誌(CD-ROM), 13(1) (1), 116 - 116, Japanese


• 脊椎用ナビゲーションシステムを用いた仙腸関節経皮的スクリュー固定の経験

  赤羽志保, 西原寛玄, 福井友章, 青木謙二, 高山博行, 原田俊彦

  (一社)日本骨折治療学会, Sep. 2013, 骨折, 35(3) (3), 784 - 787, Japanese


• 偽関節患者を対象とした,自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本知之, 新倉隆宏, 川上洋平, 福井友章, 美舩泰, 李相亮, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  (公社)日本整形外科学会, 30 Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1545 - S1545, Japanese


• 骨関節の再生医療の現状と展望 偽関節患者を対象とした、自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第I・II相臨床試験

  松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2013, 日本整形外科学会雑誌, 87(8) (8), S1545 - S1545, Japanese


• 多発外傷を伴う骨盤輪骨折の治療成績

  西原寛玄, 福井友章, 岸本健太, 青木謙二, 高山博行, 原田俊彦

  (一社)日本骨折治療学会, Jun. 2013, 骨折, 35(Suppl.) (Suppl.), S92 - S92, Japanese


• ストロンチウム‐89投与後に受傷した病的骨折に対して骨接合術を施行した乳癌多発骨転移の1例

  岸本健太, 高山博行, 青木謙二, 西原寛玄, 福井友章, 渡辺裕介, 木嶋雄介, 工藤健史, 田中聡一, 佐古田洋子, 原田俊彦

  (公社)日本整形外科学会, Jun. 2013, 日本整形外科学会雑誌, 87(6) (6), S1239 - S1239, Japanese


• 血管内皮細胞におけるSDF‐1/CXCR4シグナルは骨折治癒過程で血管・骨新生を制御する

  川上洋平, 黒田知也, 松本知之, 伊井正明, 川本篤彦, 美舩泰, 庄司太郎, 福井友章, 黒田良祐, 浅原孝之, 黒坂昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S288 - S288, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 庄司太郎, 美舩泰, 福井友章, 黒田良祐, 浅原孝之, 黒坂昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S289 - S289, Japanese


• 細胞内アダプター蛋白Lnkの局所制御による早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 美舩泰, 庄司太郎, 福井友章, 秋丸裕司, 黒田良祐, 浅原孝之, 黒坂昌弘

  (公社)日本整形外科学会, Mar. 2013, 日本整形外科学会雑誌, 87(2) (2), S239 - S239, Japanese


• 低侵襲腰椎後方椎体間固定術(MIS‐PLIF)の有用性の検討―conventional PLIFとの前向き比較試験―

  青木謙二, 原田俊彦, 高山博行, 岸本健太, 西原寛玄, 福井友章, 渡邊裕介

  (一社)日本脊椎脊髄病学会, Mar. 2013, Journal of Spine Research, 4(3) (3), 443 - 443, Japanese


• JOABPEQによる腰部脊柱管狭窄症に対する固定術と除圧術の術後経過の評価

  高山博行, 原田俊彦, 青木謙二, 岸本健太, 西原寛玄, 福井友章

  (一社)日本脊椎脊髄病学会, Mar. 2013, Journal of Spine Research, 4(3) (3), 374 - 374, Japanese


• 脊椎手術部位感染サーベイランスによる危険因子の解析

  木嶋雄介, 高山博行, 原田俊彦, 青木謙二, 岸本健太, 西原寛玄, 福井友章, 渡邊裕介, 田中聡一

  (一社)日本脊椎脊髄病学会, Mar. 2013, Journal of Spine Research, 4(3) (3), 501 - 501, Japanese


• Clinical application of drug derivery system for orthopaedic surgery

  Ryosuke Kuroda, Tomoaki Fukui, Kazunari Ishida, Ken Sasaki, Yasuhiko Tabata

  日本DDS学会, Sep. 2012, Drug Delivery System, 27(4) (4), 283 - 288, Japanese


• アテロコラーゲンを用いた細胞内アダプター蛋白Lnkの局所制御による血管・骨新生促進を介した骨折治療法

  川上洋平, 松本知之, 伊井正明, 川本篤彦, 黒田良祐, 庄司太郎, 美舩泰, 福井友章, 浅原孝之, 黒坂昌弘

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1058 - S1058, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞の局所投与は骨折治癒を促進する

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 黒田良祐, 庄司太郎, 美舩泰, 福井友章, 浅原孝之, 黒坂昌弘

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1059 - S1059, Japanese


• 骨折治癒過程におけるSDF‐1/CXCR4シグナルを介した血管内皮前駆細胞による血管・骨新生の制御

  川上洋平, 黒田知也, 松本知之, 美舩泰, 庄司太郎, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  (公社)日本整形外科学会, Aug. 2012, 日本整形外科学会雑誌, 86(8) (8), S1059 - S1059, Japanese


• 脊椎ナビゲーションを用いた仙腸関節経皮的スクリュー固定の経験

  赤羽志保, 原田俊彦, 高山博行, 青木謙二, 岸本健太, 西原寛玄, 福井友章

  (一社)日本骨折治療学会, Jun. 2012, 骨折, 34(Suppl.) (Suppl.), S276 - S276, Japanese


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療法

  川上洋平, 伊井正明, 松本知之, 川本篤彦, 庄司太郎, 福井友章, 美舩泰, 秋丸裕司, 黒田良祐, 黒坂昌弘, 浅原孝之

  16 May 2012, 再生医療, 11, 239, Japanese


• Lnkの局所制御による血管・骨新生促進を通じた骨折治癒促進効果

  川上洋平, 松本知之, 伊井正明, 川本篤彦, 美舩泰, 福井友章, 庄司太郎, 秋丸裕司, 黒田良祐, 黒坂昌弘, 浅原孝之

  16 May 2012, 再生医療, 11, 265, Japanese


• Clinical outcome of surgical treatment for acromioclavicular joint dislocation

  FUKUI Tomoaki

  (一社)中部日本整形外科災害外科学会, Mar. 2012, 中部日本整形外科災害外科学会雑誌, 55(2) (2), 339 - 340, Japanese


• Clinical outcome of surgical treatment for acromioclavicular joint dislocation

  FUKUI Tomoaki

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2012, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 55(2) (2), 339 - 340, Japanese


• Clinical application of drug derivery system for orthopaedic surgery

  Ryosuke Kuroda, Tomoaki Fukui, Kazunari Ishida, Ken Sasaki, Yasuhiko Tabata

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM, 2012, Drug Delivery System, 27(4) (4), 283 - 288, English


• 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  松本知之, 新倉隆宏, 福井友章, 美舩泰, 川上洋平, 三輪雅彦, 李相亮, 大江啓介, 川本篤彦, 黒坂昌弘, 浅原孝之, 黒田良祐

  (公社)日本整形外科学会, 25 Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1182 - S1182, Japanese


• 運動器の再生 末梢血細胞を用いた骨・血管再生療法による偽関節治療

  松本 知之, 新倉 隆宏, 福井 友章, 美舩 泰, 川上 洋平, 三輪 雅彦, 李 相亮, 大江 啓介, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1182 - S1182, Japanese


• 体外増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法

  川上洋平, 松本知之, 川本篤彦, 伊井正明, 美舩泰, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1202 - S1202, Japanese


• 細胞内アダプター蛋白質Lnkの局所制御による,早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 松本知之, 川本篤彦, 伊井正明, 美舩泰, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1214 - S1214, Japanese


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による血管新生・骨新生を介した骨折治療

  福井友章, 伊井正明, 庄司太郎, 松本知之, 美舩泰, 川上洋平, 黒田知也, 川本篤彦, 斎藤高志, 城潤一郎, 田畑泰彦, 黒坂昌弘, 黒田良祐, 浅原孝之

  (公社)日本整形外科学会, Aug. 2011, 日本整形外科学会雑誌, 85(8) (8), S1215 - S1215, Japanese


• 骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上洋平, 川本篤彦, 伊井正明, 庄司太郎, 松本知之, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 244, Japanese


• Lnkの局所制御による,早期の血管新生を通じた骨折治癒促進の可能性

  川上洋平, 川本篤彦, 伊井正明, 松本知之, 美舩泰, 福井友章, 黒田良祐, 高木智, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 226, Japanese


• 培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療戦略

  川上洋平, 川本篤彦, 伊井正明, 庄司太郎, 松本知之, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 244, Japanese


• ヌードラット大腿骨偽関節モデルに対するCD34陽性細胞および単核球の局所移植による治療効果の比較検討

  福井友章, 美舩泰, 松本知之, 庄司太郎, 川上洋平, 伊井正明, 川本篤彦, 黒田知也, 新倉隆弘, 黒坂昌弘, 黒田良祐, 浅原孝之

  01 Feb. 2011, 再生医療, 10, 247, Japanese


• 末梢血CD34陽性細胞による骨・血管再生療法

  松本知之, 美舩泰, 福井友章, 川上洋平, 三輪雅彦, 新倉隆宏, 李相亮, 大江啓介, 庄司太郎, 黒田知也, 川本篤彦, 浅原孝之, 黒坂昌弘, 黒田良祐

  (公社)日本整形外科学会, 25 Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1109 - S1109, Japanese


• 基礎研究をもとにした骨折治療の新しい流れ 末梢血CD34陽性細胞による骨・血管再生療法

  松本 知之, 美舩 泰, 福井 友章, 川上 洋平, 三輪 雅彦, 新倉 隆宏, 李 相亮, 大江 啓介, 庄司 太郎, 黒田 知也, 川本 篤彦, 浅原 孝之, 黒坂 昌弘, 黒田 良祐

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1109 - S1109, Japanese


• 体外増幅ヒトCD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上洋平, 庄司太郎, 松本知之, 美舩泰, 川本篤彦, 伊井正明, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1083 - S1083, Japanese


• ラット大腿骨偽関節モデルにおけるG‐CSF動員CD34陽性細胞移植の治療効果の検討

  福井友章, 美舩泰, 松本知之, 庄司太郎, 川上洋平, 伊井正明, 川本篤彦, 黒田知也, 新倉隆宏, 三輪雅彦, 黒田良祐, 黒坂昌弘, 浅原孝之

  (公社)日本整形外科学会, Aug. 2010, 日本整形外科学会雑誌, 84(8) (8), S1083 - S1083, Japanese


• 培養増幅ヒト骨髄由来CD34陽性細胞のラット難治性骨折モデルにおける局所移植治療効果の検討

  川上洋平, 庄司太郎, 川本篤彦, 松本知之, 伊井正明, 福井友章, 美舩泰, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 257, Japanese


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による骨折治療

  福井友章, 伊井正明, 美舩泰, 庄司太郎, 松本知之, 川上洋平, 黒田知也, 川本篤彦, 斎藤高志, 城潤一郎, 田畑康彦, 黒坂昌弘, 黒田良祐, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 298, Japanese


• ヒト骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上洋平, 庄司太郎, 川本篤彦, 松本知之, 伊井正明, 福井友章, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2010, 再生医療, 9, 296, Japanese


• 末梢血CD34陽性細胞との共培養による骨折部血腫由来細胞の早期骨分化促進の検討

  康暁博, 李相亮, 三輪雅彦, 新倉隆宏, 古賀敬章, 松本知之, 大江啓介, 福井友章, 黒田良祐, 黒坂昌弘

  05 Feb. 2010, 再生医療, 9, 297, Japanese


• 変形性膝関節症に対する第3世代ACI(Autologous Chondrocyte Implantation)を用いた治療

  黒田知也, 松本知之, 美舩泰, 福井友章, 久保晴司, 松下雄彦, 浅原孝之, 黒坂昌弘, 黒田良祐

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1312 - S1312, Japanese


• ラット大腿骨難治性骨折モデルに対するG‐CSF動員単核球細胞移植の治療効果の検討

  福井友章, 美舩泰, 松本知之, 川本篤彦, 黒田知也, 庄司太郎, 浅原孝之, 黒坂昌弘, 黒田良祐

  (公社)日本整形外科学会, Aug. 2009, 日本整形外科学会雑誌, 83(8) (8), S1238 - S1238, Japanese


• 難治性骨折に対するG‐CSF動員単核球細胞移植の治療効果

  福井友章, 美舩泰, 松本知之, 川本篤彦, 黒田知也, 庄司太郎, 黒坂昌弘, 黒田良祐, 浅原孝之

  05 Feb. 2009, 再生医療, 8, 194, Japanese


• 骨折治癒過程におけるSDF‐1/CXCR4システムを介した血管内皮前駆細胞による骨・血管新生・再生の制御

  黒田知也, 櫂相模, 庄司太郎, 美舩泰, 福井友章, 松本知之, 松下雄彦, 黒田良祐, 黒坂昌弘, 浅原孝之

  05 Feb. 2009, 再生医療, 8, 236, Japanese


• Medial migration of lag screw in gamma nailing ; a report of two cases

  FUKUI Tomoaki

  (一社)中部日本整形外科災害外科学会, Nov. 2008, 中部日本整形外科災害外科学会雑誌, 51(6) (6), 1139 - 1140, Japanese


• 大腿骨転子部骨折に対する骨接合術後にラグスクリューの近位への転位を認めた2症例

  福井友章, 吉田和也, 伊藤研二郎, 松島真司, 山田昌弘, 深澤高広

  (一社)中部日本整形外科災害外科学会, Mar. 2008, 中部日本整形外科災害外科学会雑誌, 51(春季学会) (春季学会), 172 - 172, Japanese


• ボウリング中に発生した中指基節骨のsagittal split fractureの1例

  福井 友章, 吉田 和也, 伊藤 研二郎, 松島 真司, 山田 昌弘

  スポーツ傷害フォーラム, Jan. 2008, スポーツ傷害, 13, 19 - 19, Japanese


• Clinical results of the surgical treatment for bimalleolar fractures of the ankle

  MATSUSHIMA Shinji

  THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2008, The Central Japan Journal of Orthopaedic Surgery & Traumatology, 51(1) (1), 145 - 146, Japanese


• Clinical results of the surgical treatment for bimalleolar fractures of the ankle

  MATSUSHIMA Shinji

  (一社)中部日本整形外科災害外科学会, Jan. 2008, 中部日本整形外科災害外科学会雑誌, 51(1) (1), 145 - 146, Japanese


• 当院における足関節両果骨折の観血的治療

  松島真司, 吉田和也, 山田昌弘, 伊藤研二郎, 福井友章

  (一社)中部日本整形外科災害外科学会, Sep. 2007, 中部日本整形外科災害外科学会雑誌, 50(秋季学会) (秋季学会), 52 - 52, Japanese


• 四肢に発生したSolitery Fibrous Tumorの2例

  福井友章, 川口洋治, 河野良太, 河本旭哉, 山本哲司

  中国・四国整形外科学会, Sep. 2007, 中国・四国整形外科学会雑誌, 19(2) (2), 321 - 322, Japanese


• 骨端線閉鎖前の長管骨骨端部にも病巣がみられたPolyostotic Fibrous Dysplasiaの1例

  福井友章, 川口洋治, 河野良太, 河本旭哉, 山本哲司

  (公社)日本整形外科学会, Jun. 2007, 日本整形外科学会雑誌, 81(6) (6), S767 - S767, Japanese


• Medial Patellofemoral Ligament Reconstruction for Malalignment of Patella

  福井友章, 真柴賛, 千頭憲一郎, 中溝寛之, 岩田憲, 森諭史, 山本哲司

  15 Apr. 2007, 中国・四国整形外科学会雑誌, 19(1) (1), 27 - 31, Japanese


• 膝蓋骨malalignmentに対する内側膝蓋大腿靱帯(MPFL)再建術の術後成績

  福井 友章, 真柴 賛, 千頭 憲一郎, 中溝 寛之, 岩田 憲, 森 諭史, 山本 哲司

  中国・四国整形外科学会, Apr. 2007, 中国・四国整形外科学会雑誌, 19(1) (1), 27 - 31, Japanese


• Infantile Digital Fibromatosis: Electron Microscopic Observation

  河野良太, 川口洋治, 福井友章, 河本旭哉, 山本哲司

  中国・四国整形外科学会, Apr. 2007, 中国・四国整形外科学会雑誌, 19(1) (1), 79 - 82, Japanese


• 四肢に発生した単発性線維性腫瘍の2例

  福井友章, 川口洋治, 河本旭哉, 山本哲司

  (一社)中部日本整形外科災害外科学会, Mar. 2007, 中部日本整形外科災害外科学会雑誌, 50(春季学会) (春季学会), 194 - 194, Japanese


• Clinical results of the surgical treatment for bimalleolar fractures of the ankle

  松島真司, 吉田和也, 山田昌弘, 伊藤研二郎, 福井友章

  2007, 中部日本整形外科災害外科学会雑誌, 51(1) (1), 145-146 (J-STAGE), Japanese


• Medial Patellofemoral Ligament Reconstruction for Malalignment of Patella

  Fukui Tomoaki, Mashiba Tasuku, Chikami Kenichiro, Nakamizo Hiroyuki, Iwata Ken, Mori Satoshi, Yamamoto Tetsuji

  Many surgical techniques have been reported for the treatment of malalignment of patella. Over recent years, as the medial patellofemoral ligament (MPFL) has been shown to be the primary restraint to lateral patellar translation, MPFL reconstruction has become a common procedure. The purpose of this study was to investigate the short term results of 8 cases (4 men, 4 women, mean age 22.8 years), who underwent MPFL reconstruction in our hospital using hamstring tendons. Mean follow-up period was 1.7 years. The mean Kujala score improved from preoperative 55.6 points to postoperative 95.5 points, with no occurrence of patella apprehension. Furthermore, patellofemoral alignment improved after surgery in all cases. Based on these results, we concluded that MPFL reconstruction is useful for the treatment of patella malalignment.

  The Chugoku-Shikoku Orthopaedic Association, 2007, The Journal of the Chugoku-Shikoku Orthopaedic Association, 19(1) (1), 27 - 31, Japanese


• Infantile digital fibromatosisの電顕的観察

  河野良太, 福井友章, 河本旭哉, 川口洋治, 山本哲司

  中国・四国整形外科学会, Oct. 2006, 中国・四国整形外科学会雑誌, 18(3) (3), 406 - 406, Japanese


• 反復性膝蓋骨脱臼に対するMPFL再建術の術後成績

  福井友章, 真柴賛, 五味徳之, 中溝寛之, 岩田憲, 千頭憲一郎, 森諭史, 山本哲司

  中国・四国整形外科学会, Oct. 2006, 中国・四国整形外科学会雑誌, 18(3) (3), 392 - 392, Japanese


• 同側大腿骨に骨頭下骨折と転子部骨折を同時に発生した1例

  福井友章, 平中崇文, 西原寛玄, 上本晴信, 藤田郁夫, 辻充男

  (株)南江堂, Jul. 2006, 整形外科, 57(7) (7), 793 - 795, Japanese


• 軸椎後方要素の不連続性のために脊髄症をきたした1例

  福井友章, 三浦寿一, 鷲見正敏, 笠原孝一, 中谷徹也, 金村在哲, 金谷貴子, 佐藤啓三, 山崎京子

  (一社)中部日本整形外科災害外科学会, Jul. 2006, 中部日本整形外科災害外科学会雑誌, 49(4) (4), 805 - 805, Japanese


• 臨床室 同側大腿骨に骨頭下骨折と転子部骨折を同時に発生した1例

  福井 友章, 平中 崇文, 西原 寛玄

  南江堂, Jul. 2006, 整形外科, 57(7) (7), 793 - 795, Japanese


• 小切開下半月板縫合術-改良型outside-in法

  平中 崇文, 藤田 郁夫, 上本 晴信, 西原 寛玄, 福井 友章, 辻 充男

  日本最小侵襲整形外科学会, Oct. 2005, 日本最小侵襲整形外科学会誌, 5(1) (1), 44 - 44, Japanese


• 大腿骨転子部骨折における整復後の遺残転位についての検討

  平中崇文, 藤田郁夫, 上本晴信, 西原寛玄, 福井友章, 辻充男

  10 Jun. 2005, 骨折, 27(Supplement) (Supplement), S78, Japanese


• 同側大腿骨頸部に内側骨折と外側骨折の同時骨折を来たした1例

  福井 友章, 平中 崇文, 上本 晴信, 藤田 郁夫, 辻 充男

  (一社)中部日本整形外科災害外科学会, Apr. 2005, 中部日本整形外科災害外科学会雑誌, 48(春季学会) (春季学会), 64 - 64, Japanese


• 同側大腿骨頚部に内側骨折と外側骨折の同時骨折を来たした1例

  福井友章, 平中崇文, 上本晴信, 藤田郁夫, 辻充男

  01 Apr. 2005, 中部日本整形外科災害外科学会雑誌, 48, 64, Japanese


• 小児に発生した舟状骨・有頭骨同時骨折の1例

  福井友章, 藤岡宏幸, 国分毅, 中路教義, 松本知之, 黒坂昌弘

  (一社)中部日本整形外科災害外科学会, May 2004, 中部日本整形外科災害外科学会雑誌, 47(3) (3), 597 - 597, Japanese

• 血管再生治療 現状から未来を展望する

  福井 友章

  Contributor, 血管内皮前駆細胞VS単核球細胞。血管内皮前駆細胞とスタチン。, 診断と治療社, Jan. 2012

• Surgical treatment with locking plate for nonunion in femur and tibia

  Fukui T, Niikura T, Oe K, Kuroda R

  Orthopaedic Trauma Association Annual Meeting, Sep. 2019, English, International conference


• A Case of Surgically Treated Septic Arthritis of the Pubic Symphysis in Football Player

  Fukui T, Niikura T, Oe K, Matsushita T, Araki D, Kuroda R

  28th Isokinetic Medical Group Conference, Apr. 2019, English, International conference


• 炭酸ガス経皮吸収は1型糖尿病ラット骨折モデルにおいて骨癒合を促進させる

  小田 崇弘, 新倉 隆宏, 福井 友章, 大江 啓介, 新倉 路生, 黒岩 祐, 隈部 洋平, 澤内 健一, 酒井 良忠, 黒田 良祐

  第34回日本整形外科学会基礎学術集会, 2019


• 炭酸ガス経皮吸収はウサギ脛骨骨延長術における骨形成を促進する

  隈部 洋平, 新倉 隆宏, 福井 友章, 高原 俊介, 黒岩 祐, 新倉 路生, 大江 啓介, 小田 崇弘, 澤内 健一, 黒田 良祐

  第34回日本整形外科学会基礎学術集会, 2019


• 57年来の大腿骨慢性骨髄炎の一例

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  第25回日本運動器再建・イリザロフ法研究会, 2019


• 腫瘍性骨軟化症に伴う大腿骨頚部病的骨折の1例

  井上 悠, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  第453回整形外科集談会京阪神地方会, 2019


• 大腿骨頚部骨折の術後CT画像評価方法の検討

  大江 啓介, 新倉 隆宏, 福井 友章, 岩倉 崇, 櫻井 敦志, 黒田 良祐

  第45回日本骨折治療学会, 2019


• 整形外傷領域における再生医療

  新倉 隆宏, 松本 知之, 美舩 泰, 福井 友章, 大江 啓介, 黒田 良祐

  第92回日本整形外科学会学術総会, 2019


• 骨格筋量制御におけるKLF15の機能の解析

  平田 悠, 野村 和弘, 小林 憲太, 岡本 士毅, 箕越 靖彦, 小田 崇弘, 福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐, 細岡 哲也, 小川 渉

  第56回日本臨床分子医学会学術集会, 2019


• 座骨結節裂離骨折偽関節に対し手術加療を行った1例

  中松 裕太, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  第132回中部日本整形外科災害外科学会学術集会, 2019


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果

  隈部 洋平, 新倉 隆宏, 大江 啓介, 福井 友章, 高原 俊介, 新倉 路生, 黒岩 祐, 小田 祟弘, 澤内 健一, 黒田 良祐

  第32回日本創外固定・骨延長学会, 2019


• 上腕骨骨幹部偽関節に対し髄内釘を用いて手術を行った一例

  福井 友章, 大江 啓介, 新倉 隆宏

  第31回兵庫県骨折治療研究会, 2019


• 文書を用いた患者説明によるLIPUSコンプライアンス向上の効果

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  第45回日本骨折治療学会, 2019


• 下肢長管骨偽関節に対するロッキングプレートを用いた手術の治療成績

  福井 友章, 新倉 隆宏, 大江 啓介, 黒田 良祐

  第45回日本骨折治療学会, 2019


• 患者立脚型機能評価による大腿骨・脛骨偽関節の治療成績の検討

  福井 友章, 新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 黒田 良祐

  第92回日本整形外科学会学術総会, 2019


• 文書を用いた説明による超音波骨折治療器使用における患者コンプライアンス向上の試み

  福井 友章, 大江 啓介, 新倉 隆宏, 黒田 良祐

  第22回超音波骨折治療研究会, 2019


• Soluble Fibrin Monomer Complex Can Be A Useful Predictor Of Venous Thromboembolism After Fracture Surgery

  Fukui T, Lee SY, Iwakura T, Kuroda R, Niikura T

  20th EFFORT Annual Congress Lisbon 2019, 2019


• Endochondral Bone Regeneration Using Chondrogenically Differentiated Human Induced Pluripotent Stem Cells

  Lee SY, Arakura M, Fukui T, Kuroda R, Niikura T

  20th EFFORT Annual Congress Lisbon 2019, 2019


• Transcutaneous CO2 Application Accelerates Bone Fracture Healing in Diabetic Rats

  Oda T, Niikura T, Oe K, Fukui T, Kuroiwa Y, Kumabe Y, Sawauchi K, Sakai Y, Kuroda R

  4th AOTrauma Asia Pacific Scietific Congerss 2019, 2019


• Minimally invasive plate osteosynthesis for the treatment of humeral shaft nonunion: A report of two cases

  Sawauchi K, Oe K, Fukui T, Kuroda R, Niikura T

  4th AOTrauma Asia Pacific Scietific Congerss 2019, 2019


• Reamer irrigator aspirator (RIA) を日本人患者に使用した臨床経験

  新倉 隆宏, 大江 啓介, 福井 友章, 工藤 健史, 黒田 良祐

  第92回日本整形外科学会学術総会, 2019


• Periprosthetic femoral fracture with features of atypical femoral fracture: A case report

  Kumabe Y, Niikura T, Oe K, Fukui T, Kudo K, Kuroda R

  European Society for Trauma & Emergency Surgery Congress 2019, 2019


• Translational research of CD34-posutuve cell transplantation for fracture nonunion

  Niikura T, MatsumotoT, Mifune Y, Fukui T, Oe K, Kuroda R

  The 45th annual meeting of the Korean Fracture Society, 2019


• Transcutaneous CO2 application Accelerates Bone Healing in a Rat Femoral Defect Model

  Kuroiwa Y, Niikura T, Takahara S, Lee SY, Oe K, Fukui T, Arakura M, Kumabe Y, Oda T, Sawauchi K, Akisue T, Sakai Y, Kuroda R

  The 65th Orthopaedic Research Society 2023 Annual Meeting, 2019


• Effect of Transcutaneous Application of CO2 onBone Regeneration in Distraction Osteogenesis

  Kumabe Y, Niikura T, Oe K, Fukui T, Takahara S, Kuroiwa Y, Oda T, Sawauchi K, Kuroda R

  The 65th Orthopaedic Research Society 2022 Annual Meeting, 2019


• Transcutaneous CO2 Application Accelerates Bone Fracture Healing in Streptozotocin-Diabetic Rats

  Oda T, Niikura T, Oe K, Fukui T, Kuroiwa Y, Kumabe Y, Sawauchi K, Sakai Y, Kuroda R

  The 65th Orthopaedic Research Society 2021 Annual Meeting, 2019


• Bone Regeneration through Endochondral Ossification Achieved with Chondrogenically DifferentiatedHuman Induced Pluripotent Stem Cells

  Arakura M, Lee SY, Fukui T, Oe K, Takahara S, Kuroiwa Y, Kumabe Y, Kuroda R, Niikura T

  The 65th Orthopaedic Research Society 2020 Annual Meeting, 2019


• Safety And Bactericidal Effect Of 222nm Ultraviolet C Irradiation

  Sawauchi K, Fukui T, Niikura T, Oda T, Kumabe Y, Oe K, Kuroda R

  The 65th Orthopaedic Research Society 2019 Annual Meeting, 2019


• インプラント周囲上腕骨骨折後に特殊な形態の偽関節となった1例の治療経験

  飯盛 信哉, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  第29回兵庫県骨折治療研究会, 2018


• 炭酸ガス経皮吸収がラットの筋組織に及ぼす影響

  大江 啓介, 新倉 隆宏, 福井 友章, 黒岩 祐, 隈部 洋平, 小田 崇弘, 澤内 健一, 酒井 良忠, 黒田 良祐

  第33回日本整形外科学会基礎学術集会, 2018


• ヒトiPS細胞による軟骨内骨化を介した骨再生療法

  新倉 路生, 李 相亮, 福井 友章, 大江 啓介, 高原 俊介, 黒岩 祐, 隈部 洋平, 黒田 良祐, 新倉 隆宏

  第33回日本整形外科学会基礎学術集会, 2018


• ラット骨欠損モデルにおけるCO2経皮吸収の骨形成促進作用についての検討

  黒岩 祐, 新倉 隆宏, 高原 俊介, 李 相亮, 大江 啓介, 福井 友章, 新倉 路生, 隈部 洋平, 小田 崇弘, 酒井 良忠, 黒田 良祐

  第33回日本整形外科学会基礎学術集会, 2018


• 広範切除から 14 年後に再発を認めた脛骨 Adamantinoma の一例

  瀧上 俊作, 福井 友章, 河本 旭哉, 戸祭 正喜, 新倉 隆宏, 黒田 良祐

  第131回中部日本整形外科災害外科学会, 2018


• 同側大腿骨・脛骨開放性骨折後の感染に対してヨードコーティング腫瘍用人工膝関節置換を行った1例

  大澤 慎, 大江 啓介, 福井 友章, 新倉 隆宏, 黒田 良祐

  第131回中部日本整形外科災害外科学会, 2018


• 日本人におけるreamer irrigator aspirator(RIA)の使用経験

  新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  第91回日本整形外科学会学術総会, 2018


• インプラント周囲での非定型大腿骨骨折の1例

  田中 秀弥, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  中部日本整形外科学会, 2018


• 難治性骨折患者を対象とした自家末梢血CD34陽性細胞移植療法 ―医師主導治験の経験からー

  黒田 良祐, 大江 啓介, 福井 友章, 新倉 隆宏, 松本 知之

  第17回日本再生医療学会総会, 2018


• 骨延長術における炭酸ガス経皮吸収の骨形成促進効果について

  隈部 洋平, 新倉 隆宏, 福井 友章, 大江 啓介, 高原 俊介, 新倉 路生, 黒岩 祐, 小田 崇弘, 黒田 良祐

  第17回日本再生医療学会総会, 2018


• 上腕骨骨幹部偽関節術後偽関節に対してMIPO法にて治療した2例

  栖田 慶仁, 大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  第451回整形外科集談会京阪神地方会, 2018


• 超音波骨折治療におけるコンプライアンス向上のための試み（第2報）

  大江 啓介, 福井 友章, 黒田 良祐, 新倉 隆宏

  第21回超音波骨折治療研究会, 2018


• 222nm紫外線照射の安全性と殺菌効果の検討

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  第33回日本整形外科学会基礎学術集会, 2018


• 患者立脚型機能評価を用いた下肢偽関節治療成績

  福井 友章, 大江 啓介, 黒田 良祐, 新倉 隆宏

  第44回日本骨折治療学会, 2018


• 222nm紫外線照射の安全性および殺菌効果

  福井 友章, 新倉 隆宏, 小田 崇弘, 隈部 洋平, 大江 啓介, 黒田 良祐

  第41回日本骨・関節感染症学会, 2018


• 患者立脚型機能評価を含めた下肢偽関節治療経過の検討

  福井 友章, 岩倉 崇, 李 相亮, 大江 啓介, 黒田 良祐, 新倉 隆宏

  第91回日本整形外科学会学術集会, 2018


• 難治骨折診療 up-to-date

  福井 友章

  第28回 兵庫県骨折治療研究会, 2018


• Atypical femoral fractures in patients of metastatic bone tumor treated with zoledronic acid and denosumab.

  Fukui T, Lee SY, Niikura T, Oe K, Iwakura T, Sakurai A, Kuroda R

  ORS International Section Fracture Repair 2018, 2018


• Evaluation of clinical results of lower limb nonunion based on patient-reported outcome.

  Fukui T, Niikura T, Oe K, Kuroda R

  ORS International Section Fracture Repair 2018, 2018


• Safety and bactericidal effect of 222nm ultraviolet C irradiation.

  Fukui T, Niikura T, Oda T, Kumabe Y, Oe K, Kuroda R

  ORS International Section Fracture Repair 2018, 2018


• Safety and bactericidal effect of 222nm ultraviolet irradiation.

  Fukui T, Lee SY, Niikura T, Oe K, Iwakura T, Sakurai A, Kuroda R

  The 39th SICOT Orthopaedic World Congress 2018, 2018


• Atypical femoral fractures in metastatic bone tumor patients treated with zoledronic acid and denosumab.

  Fukui T, Lee SY, Niikura T, Oe K, Iwakura T, Sakurai A, Kuroda R

  European Society for Trauma & Emergency Surgery Congress 2018, 2018


• 大腿骨近位部骨折を起こした高齢者におけるビタミンD充足度の調査

  新倉 隆宏, 大江 啓介, 岩倉 崇, 李 相亮, 福井 友章, 櫻井 敦志, 酒井 良忠, 黒田 良祐

  第19回日本骨粗鬆症学会, 2017


• 骨折治癒過程におけるmicroRNAの発現：糖尿病・健常ラット間の比較検討

  高原 俊介, 李 相亮, 新倉 隆宏, 大江 啓介, 福井 友章, 新倉 路生, 黒岩 祐, 隈部 洋平, 酒井 良忠, 黒田 良祐

  第32回日本整形外科学会基礎学術集会, 2017


• 大腸菌由来BMP-2含有β-TCP顆粒はウサギ大腿骨骨欠損の骨形成を促進する

  新倉 路生, 新倉 隆宏, 李 相亮, 岩倉 崇, 福井 友章, 高原 俊介, 黒岩 祐, 隈部 洋平, 酒井 良忠, 黒田 良祐

  第32回日本整形外科学会基礎学術集会, 2017


• 骨形成不全症に合併した上腕骨骨幹部偽関節に対して下顎骨用locking plate を用いて治療した1 例

  佐野 翔平, 新倉 隆宏, 大江 啓介, 福井 友章, 黒田 良祐

  第129回中部日本整形外科災害外科学会, 2017


• CO?経皮吸収はラット骨欠損モデルにおいて骨形成を促進させる

  小田 崇弘, 黒岩 祐, 高原 俊介, 新倉 路生, 隈部 洋平, 李 相亮, 大江 啓介, 岩倉 崇, 福井 友章, 酒井 良忠, 新倉 隆宏, 黒田 良祐

  第36回運動器移植再生医学研究会, 2017


• 偽関節手術後に低出力超音波パルスを使用した症例についての検討

  李 相亮, 新倉 隆宏, 福井 友章, 大江 啓介, 黒田 良祐

  第43回日本骨折治療学会, 2017


• PTH間歇投与はラット難治性骨折モデルにおける骨癒合を促進させる

  李 相亮, 脇 貴洋, 岩倉 崇, 高原 俊介, 新倉 路生, 福井 友章, 黒田 良祐, 新倉 隆宏

  第43回日本骨折治療学会, 2017


• 炭酸ガス経皮吸収は安全に骨折患者の患肢血流を増加できる−臨床試験の報告−

  新倉 隆宏, 岩倉 崇, 李 相亮, 大江 啓介, 福井 友章, 酒井 良忠, 黒田 良祐

  第43回日本骨折治療学会, 2017


• 骨粗鬆症性椎体骨折地域連携パス導入による効果 -治療継続率の向上と骨折連鎖の予防を目指して-

  原田 俊彦, 岸本 健太, 高山 博行, 青木 健二, 西原 寛玄, 市村 克仁, 福井 友章, 中川 夏子, 上藤 淳郎

  第90回日本整形外科学会学術総会, 2017


• 非定型大腿骨骨折に対する低出力超音波パルスの使用経験

  李相 亮, 新倉 隆宏, 岩倉 崇, 福井 友章, 黒田 良祐

  第20回超音波骨折治療研究会, 2017


• 大腿骨近位部骨折に対する 髄内釘固定後の折損例の検討

  福井 友章, 新倉 隆宏, 李 相亮, 黒田 良祐

  第43回日本骨折治療学会, 2017


• プロサッカー選手におけるハムストリング肉離れからの復帰時期

  福井 友章, 原田 俊彦, 松下 雄彦, 柳田 博美, 黒田 良祐

  第90回日本整形外科学会学術集会, 2017


• ゾレドロン酸・デノスマブ投与中の 癌骨転移患者に発生した 非定型大腿骨骨折についての検討

  福井 友章, 李 相亮, 新倉 隆宏, 岩倉 崇, 櫻井 敦志, 黒田 良祐

  第128回中部日本整形外科災害外科学会, 2017


• Time of Return to Play from Hamstring Injury in Professional Soccer Players

  Fukui T, Harada T, Matsushita T, Yanagida H, Kuroda R

  The 26th International Conference of Sport Rehabilitation and Traumatology Football Medicine Strategies, 2017


• The Effect of Inhibitors of Brd4 and CDK9 on Early Phase of Post Traumatic Osteoarthritis

  Fukui T, Jasper Y, Haddad A, Davis J, Adamopoulos I, Haudenschild D

  The 63th Annual Meeting of the Orthopaedic Research Society, 2017


• リウマチ患者における骨粗鬆症治療の現状

  上藤 淳郎, 中川 夏子, 原田 俊彦, 高山 博行, 青木 謙二, 岸本 健太, 西原 寛玄, 市村 克仁, 福井 友章

  第44回日本関節病学会, 2016


• 当センターにおける大腿骨近位部骨折患者の骨粗鬆症治療薬継続率

  岸本 健太, 原田 俊彦, 中川 夏子, 高山 博行, 青木 謙二, 西原 寛玄, 市村 克仁, 福井 友章, 上藤 淳郎, 谷口 光子

  第18回日本骨粗鬆症学会, 2016


• 多椎間狭窄の頚椎症性脊髄症に対する棘突起縦割式椎弓形成術と選択的椎弓切除術の前向きランダム化比較

  市村 克仁, 高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 福井 友章

  第89回日本整形外科学会学術総会, 2016


• 腰部脊柱管狭窄症の手術成績に糖尿病が及ぼす影響について

  高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 市村 克仁, 福井 友章

  第45回日本脊椎脊髄病学会, 2016


• 骨粗鬆症・脊椎椎体骨折地域連携パス適応症例の追跡調査

  高瀬 恭平, 岸本 健太, 原田 俊彦, 高山 博行, 青木 謙二, 西原 寛玄, 市村 克仁, 福井 友章

  第126回中部日本整形外科災害外科学会, 2016


• A Case of Chondrosarcoma of Rib in a Professional Football Player

  Fukui T, Fujita I, Harada T

  The 25th International Conference of Sport Rehabilitation and Traumatology Football Medicine Strategies, 2016


• The Effect of Inhibitors of Brd4 and CDK9 on Post Traumatic Osteoarthritis

  Fukui T, Yik J, Davis J, Adamopoulos I, Haudenschild D

  The 62th Annual Meeting of the Orthopaedic Research Society, 2016


• 骨粗鬆症・脊椎椎体骨折地域連携パス―導入の背景と今後の展望-

  高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 市村 克仁, 福井 友章

  第16回日本クリニカルパス学会, 2015


• プロサッカー選手における脛骨疲労骨折に対する治療経験

  福井 友章, 原田 俊彦, 柳田 博美, 角田 雅也

  第26回日本臨床スポーツ医学会, 2015


• In-vitro and In-vivo Imaging of MMP Activity with MMPSense in Cartilage and Joint Injury

  Fukui T, Tenborg E, Yik J, Haudenschild D

  The 12th World Congress of the International Cartilage Repair Society (ICRS), 2015


• Transcriptome Analysis of Aging-Related \vResponse to Knee Injury

  Fukui T, Castillo AB, Yik J, Haudenschild DR

  The 25th Osteoarthritis Research Society International (OARSI), 2015


• The In Vivo and In Vitro Effect of Inhibitors of Brd4 and CDK9 on Early Phase of Post Traumatic Osteoarthritis

  Fukui T, Yik J, Haudenschild D

  The 25th Osteoarthritis Research Society International (OARSI), 2015


• Comprehensive Transcriptome Analysis of Aging-related Change in Early Phase of Post-traumatic Osteoarthritis

  Fukui T, Castillo AB, Russell A, Yik J, Haudenschild DR

  The 61th Annual Meeting of the Orthopaedic Research Society, 2015


• In-vitro and In-vivo Imaging of MMP Activity in Cartilage and Joint Injury.

  Fukui T, Tenborg E, Yik J, Haudenschild D

  The 61th Annual Meeting of the Orthopaedic Research Society, 2015


• The Effect of Inhibitors of Brd4 and CDK9 on Early Phase of Post Traumatic Osteoarthritis

  Fukui T, Yik J, Haudenschild D

  The 61th Annual Meeting of the Orthopaedic Research Society, 2015


• 血管内皮細胞におけるSDF-1/CXCR4シグナルは骨折治癒過程において血管・骨新生の制御する

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 美舩 泰, 黒田 知也, 庄司 太郎, 福井 友章, 黒田 良祐, 浅原 孝之, 黒坂 昌弘

  第87回日本整形外科学会学術総会, 2014


• 偽関節患者を対象とした、自家末梢血CD34陽性細胞を用いた骨・血管再生療法.

  松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  第11回日本再生医療学会, 2014


• In-vitro and in-vivo imaging of MMP activity in cartilage and joint injury

  Fukui T, Tenborg E, Yik J, Haudenschild D

  UC Davis Biomedical Imaging Conference, 2014


• Inhibition of CDK9 and BRD4 in Chondrocytes Under Inflammatory Stimuli

  Fukui T, Yik J, Haudenschild D

  The 60th Annual Meeting of the Orthopaedic Research Society, 2014


• 偽関節患者を対象とした、自家末梢血CD34陽性細胞を用いた骨・血管再生療法に関する第?・?相臨床試験

  松本 知之, 新倉 隆宏, 川上 洋平, 福井 友章, 美舩 泰, 李 相亮, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  第28回 日本整形外科学会基礎学術集会, 2013


• ストロンチウム-89投与後に受傷した病的骨折に対して骨接合術を施行した乳癌多発骨転移の1例

  岸本 健太, 高山 博行, 青木 謙二, 西原 寛玄, 福井 友章, 渡邊 裕介, 木嶋 雄介, 工藤 健史, 田中 聡一, 原田 俊彦

  第46回日本整形外科学会 骨・軟部腫瘍学術集会, 2013


• 多発外傷を伴う骨盤輪骨折の治療成績

  西原 寛玄, 福井 友章, 岸本 健太, 青木 謙二, 高山 博行, 原田 俊彦

  第39回日本骨折治療学会, 2013


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, 美舩 泰, 福井 友章, 黒田 良祐, 浅原 孝之, 黒坂 昌弘

  第86回日本整形外科学会学術総会, 2013


• 血管内皮細胞におけるSDF-1/CXCR4シグナルは骨折治癒過程で血管・骨新生を制御する

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 美舩 泰, 福井 友章, 庄司 太郎, 黒田 知也, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第86回日本整形外科学会学術総会, 2013


• アテロコラーゲンを用いた細胞内アダプター蛋白Lnkの局所制御による血管・骨新生促進を介した骨折治療法

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 黒田 良祐, 美舩 泰, 庄司 太郎, 福井 友章, 黒坂 昌弘, 浅原 孝之

  第86回日本整形外科学会学術総会, 2013


• 脊椎手術部位感染サーベイランスによる危険因子の解析

  木嶋 雄介, 高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 福井 友章, 田中 聡一

  第42回日本脊椎脊髄病学会, 2013


• 低侵襲腰椎後方椎体間固定術(MIS-PLIF)の有用性の検討-conventional PLIFとの前向き比較試験-

  青木 謙二, 原田 俊彦, 高山 博行, 岸本 健太, 西原 寛玄, 福井 友章

  第42回日本脊椎脊髄病学会, 2013


• JOABPEQによる腰部脊柱管狭窄症に対する固定術と除圧術の術後経過の評価

  高山 博行, 原田 俊彦, 青木 謙二, 岸本 健太, 西原 寛玄, 福井 友章

  第42回日本脊椎脊髄病学会, 2013


• 脊椎ナビゲーションシステムを用いた仙腸関節経皮的スクリュー固定の経験

  赤羽 志保, 西原 寛玄, 青木 謙二, 岸本 健太, 高山 博行, 福井 友章, 原田 俊彦

  第18回日本最小侵襲整形外科学会, 2012


• 体外培養増幅ヒト骨髄由来CD34陽性細胞の局所投与は骨折治癒を促進する

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, 黒田 良祐, 庄司 太郎, 美舩 泰, 福井 友章, 浅原 孝之, 黒坂 昌弘

  第27回日本整形外科学会基礎学術集会, 2012


• 骨折治癒過程におけるSDF1/CXCR4シグナルを介した血管内皮前駆細胞による血管・骨新生の制御

  川上 洋平, 黒田 知也, 松本 知之, 美舩 泰, 庄司 太郎, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第27回日本整形外科学会基礎学術集会, 2012


• アテロコラーゲンを用いた細胞内アダプター蛋白Lnkの局所制御による血管・骨新生促進を介した骨折治療法

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 黒田 良祐, 庄司 太郎, 美舩 泰, 福井 友章, 浅原 孝之, 黒坂 昌弘

  第27回日本整形外科学会基礎学術集会, 2012


• 当院におけるMIS-TKAの治療成績

  西原 寛玄, 福井 友章, 岸本 健太, 青木 謙二, 高山 博行, 原田 俊彦

  第4回JOSKAS, 2012


• 脊椎ナビゲーションを用いた仙腸関節経皮的スクリュー固定の経験

  赤羽 志保, 西原 寛玄, 青木 謙二, 岸本 健太, 高山 博行, 福井 友章, 原田 俊彦

  第38回日本骨折治療学会, 2012


• 体外培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療法

  川上 洋平, 伊井 正明, 松本 知之, 川本 篤彦, 庄司 太郎, 福井 友章, 美舩 泰, 秋丸 裕司, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第11回日本再生医療学会, 2012


• Lnkの局所制御による、血管・骨新生促進を通じた骨折治癒促進効果

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 美舩 泰, 福井 友章, 庄司 太郎, 秋丸 裕司, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第11回日本再生医療学会, 2012


• A small interfering RNA targeting Lnk using atelocolagen as a scaffold is effective in treatment of bone fracture vis early neovascularization

  Kawakami Y, Matsumoto T, Ii M, Kawamoto A, Kuroda R, Mifune Y, Shoji T, Fukui T, Kurosaka M, Asahara T

  The 13th ISFR(The International Society for Fracture Repair) Biennial Conference, 2012


• SDF-1/CXCR4 Axis Regulate Both Vasculogenesis and Osteogenesis for Bone Fracture Healing

  Kawakami Y, Matsumoto T, Ii M, Kawamoto A, Mifune Y, Shoji T, Fukui T, Kuroda R, Kurosaka M, Asahara T

  Golden Jubilee Congress of the Asia Pacific Orthopaedic Association (APOA), 2012


• The New Strategy for Fracture Healing by Ex-vivo Expanded Bone Marrow CD34 Positive Progenitor Cells

  Kawakami Y, Kuroda T, Matsumoto T, Kawamoto A, Ii M, Mifune Y, Fukui T, Shoji T, Kuroda R, Kurosaka M, Asahara T

  Golden Jubilee Congress of the Asia Pacific Orthopaedic Association (APOA), 2012


• Local Transplantation of Ex-vivo Expanded Bone Marrow-derived CD34 Positive Progenitor Cells Accelerate non-Union Fracture Healing

  Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Mifune Y, Shoji T, Fukui T, Kuroda R, Kurosaka M, Asahara T

  The 58th Annual Meeting of the Orthopaedic Research Society, 2012


• A Small Interfering RNA Targeting Lnk Using Atelocolagen as a Scaffold is Effective in Treatment of Unhealing Bone Fracture via Early Neovascularization.

  Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Mifune Y, Fukui T, Shoji T, Kuroda R, Kurosaka M, Asahara T

  The 58th Annual Meeting of the Orthopaedic Research Society, 2012


• A SMALL INTERFERING RNA TARGETING LNK USING ATELOCOLAGEN AS A SCAFFOLD

  川上 洋平, 松本 知之, 伊井 正明, 川本 篤彦, 美舩 泰, 庄司 太郎, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第3回先進医療フォーラム, 2012


• LOCAL DELIVERY OF EX-VIVO EXPANDED BONE MARROW CD34 POSITIVE PROGENITOR CELLS USING BIOSCAFFOLD FOR TREATMENT OF UNHEALING BONE FRACTURE

  川上 洋平, 伊井 正明, 川本 篤彦, 松本 知之, 美舩 泰, 庄司 太郎, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第3回先進医療フォーラム, 2012


• 肩鎖関節脱臼に対する術後成績の検討

  福井 友章, 渡邉 裕介, 堀 芳郎, 青木 謙二, 高山 博行, 西原 寛玄, 原田 俊彦

  第117回中部日本整形外科災害外科学会, 2011


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による血管新生・骨新生を介した骨折治療

  福井 友章, 伊井 正明, 美舩 泰, 庄司 太郎, 松本 知之, 川上 洋平, 黒田 知也, 川本 篤彦, 斎藤 高志, 城 潤一郎, 田畑 康彦, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

  第26回日本整形外科学会基礎学術集会, 2011


• ヌードラット大腿骨偽関節モデルに対するCD34陽性細胞および単核球の局所移植による治療効果の比較検討

  福井 友章, 美舩 泰, 松本 知之, 庄司 太郎, 川上 洋平, 伊井 正明, 川本 篤彦, 黒田 知也, 新倉 隆宏, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

  第10回日本再生医療学会, 2011


• Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel contributes to Fracture Repair via Angiogenesis Concerning EPC and Osteogenesis

  Fukui T, Ii M, Shoji T, Matsumoto T, Mifune Y, Kawakami Y, Kuroda T, Akimaru H, Kawamoto A, Jo J, Tabata Y, Kurosaka M, Kuroda R, Asahara T

  The Annual Meeting of the Asia Pacific Chapter of the Tissue Engineering and Regenerative Medicine International Society (TERMIS-AP), 2011


• Efficacy of Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cell Transplantation for Nonunion of Bone Fractures Compared with Total Mononuclear Cells

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Ii M, Kawamoto Y, Kuroda T, Niikura T, Miwa M, Kuroda R, Kurosaka M, Asahara T

  The 57th Annual Meeting of the Orthopaedic Research Society, 2011


• Therapeutic Effect of Low Dose Simvastatin-conjugated Gelatin Hydrogel for Fracture Healing via Activating Endothelial Progenitor Cells and Osteoblasts

  Fukui T, Ii M, Shoji T, Matsumoto T, Mifune Y, Kawakami Y, Kuroda T, Akimaru H, Kawamoto A, Saito T, Jo J, Tabata Y, Kurosaka M, Kuroda R, Asahara T

  The 57th Annual Meeting of the Orthopaedic Research Society, 2011


• 末梢血細胞を用いた骨・血管再生療法による偽関節治療.

  松本 知之, 新倉 隆宏, 福井 友章, 美舩 泰, 川上 洋平, 三輪 雅彦, 李 相亮, 大江 啓介, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  第26回日本整形外科学会基礎学術集会, 2011


• 体外増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折に対する新規治療法

  川上 洋平, 松本 知之, 川本 篤彦, 伊井 正明, 美舩 泰, 福井 友章, 庄司 太郎, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第26回日本整形外科学会基礎学術集会, 2011


• 細胞内アダプター蛋白質Lnkの局所制御による, 早期の血管新生を通じた骨折治癒促進の可能性

  川上 洋平, 松本 知之, 川本 篤彦, 伊井 正明, 美舩 泰, 福井 友章, 庄司 太郎, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第26回日本整形外科学会基礎学術集会, 2011


• 骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上 洋平, 川本 篤彦, 伊井 正明, 松本 知之, 庄司 太郎, 福井 友章, 美舩 泰, 黒田 良祐, 高木 智, 黒坂 昌弘, 浅原 孝之

  第10回日本再生医療学会, 2011


• 培養増幅ヒト骨髄由来CD34陽性細胞を用いた難治性骨折の新規治療戦略

  川上 洋平, 川本 篤彦, 伊井 正明, 松本 知之, 庄司 太郎, 福井 友章, 美舩 泰, 黒田 良祐, 高木 智, 黒坂 昌弘, 浅原 孝之

  第10回日本再生医療学会, 2011


• Lnkの局所制御による、早期の血管新生を通じた骨折治癒促進の可能性

  川上 洋平, 川本 篤彦, 伊井 正明, 松本 知之, 美舩 泰, 福井 友章, 黒田 良祐, 高木 智, 黒坂 昌弘, 浅原 孝之

  第10回日本再生医療学会, 2011


• ラット大腿骨偽関節モデルにおけるG-CSF 動員CD34 陽性細胞移植の治療効果の検討

  福井 友章, 美舩 泰, 松本 知之, 庄司 太郎, 川上 洋平, 伊井 正明, 川本 篤彦, 黒田 知也, 新倉 隆宏, 三輪 雅彦, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

  第25回日本整形外科学会基礎学術集会, 2010


• ゼラチンハイドロゲルに包含した低用量シンバスタチン局所投与による骨折治療

  福井 友章, 伊井 正明, 美舩 泰, 庄司 太郎, 松本 知之, 川上 洋平, 黒田 知也, 川本 篤彦, 斎藤 高志, 城 潤一郎, 田畑 康彦, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

  第9回日本再生医療学会, 2010


• Therapeutic Effect of Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel for Fracture Healing via Angiogenesis and Osteogenesis

  Fukui T, Ii M, Mifune Y, Shoji T, Matsumoto T, Kawakami Y, Kuroda T, Akimaru H, Kawamoto A, Jo J, Tabata Y, Kurosaka M, Kuroda R, Asahara T

  The 7th Combined Meeting of the Orthopaedic Research Societies, 2010


• Efficacy of Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cell Transplantation for Nonunion of Bone Fractures Compared with Total Mononuclear Cells

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Ii M, Kawamoto Y, Kuroda T, Niikura T, Miwa M, Kuroda R, Kurosaka M, Asahara T

  The 7th Combined Meeting of the Orthopaedic Research Societies, 2010


• Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel

  Fukui T, Ii M, Shoji T, Mifune Y, Matsumoto T, Kawakami Y, Akimaru H, Kawamoto A, Kuroda T, Saito T, Jo J, Tabata Y, Kuroda R, Kurosaka M, Asahara T

  The 12th International Society for Fracture Repair Biennial Conference, 2010


• Therapeutic Effect of Local Administration of Low Dose Simvastatin-conjugated Gelatin Hydrogel for Fracture Healing

  Fukui T, Ii M, Mifune Y, Shoji T, Matsumoto T, Kawakami Y, Kuroda T, Akimaru H, Kawamoto A, Jo J, Tabata Y, Kurosaka M, Kuroda R, Asahara T

  The 56th Annual Meeting of the Orthopaedic Research Society, 2010


• The New Strategy for Fracture Healing of Pseudoarthrosis by Granulocyte Colony Stimulating Factor-Mobilized CD34-Positive Progenitor Cells

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kawakami Y, Kawamoto Y, Kuroda T, Niikura T, Miwa M, Kuroda R, Kurosaka M, Asahara T

  The 56th Annual Meeting of the Orthopaedic Research Society, 2010


• 末梢血CD34陽性細胞による骨・血管再生療法

  松本 知之, 美舩 泰, 福井 友章, 川上 洋平, 三輪 雅彦, 新倉 隆宏, 李 相亮, 大江 啓介, 庄司 太郎, 黒田 知也, 川本 篤彦, 黒坂 昌弘, 浅原 孝之, 黒田 良祐

  第25回日本整形外科学会基礎学術集会, 2010


• 体外増幅ヒトCD34陽性細胞を用いた難治性骨折に対する新規治療法の開発

  川上 洋平, 庄司 太郎, 松本 知之, 川本 篤彦, 伊井 正明, 美舩 泰, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第25回日本整形外科学会基礎学術集会, 2010


• ヒト骨髄由来CD34陽性細胞の間葉系細胞への分化能に関する検討

  川上 洋平, 庄司 太郎, 松本 知之, 美舩 泰, 川本 篤彦, 伊井 正明, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第9回日本再生医療学会, 2010


• 培養増幅ヒト骨髄由来CD34陽性細胞のラット難治性骨折モデルにおける局所移植治療効果の検討

  川上 洋平, 庄司 太郎, 松本 知之, 川本 篤彦, 伊井 正明, 美舩 泰, 福井 友章, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第9回日本再生医療学会, 2010


• ラット大腿骨難治性骨折モデルに対するG-CSF動員単核球細胞移植の治療効果の検討

  福井 友章, 美舩 泰, 松本 知之, 川本 篤彦, 黒田 知也, 庄司 太郎, 浅原 孝之, 黒坂 昌弘, 黒田 良祐

  第24回 日本整形外科学会基礎学術集会, 2009


• 難治性骨折に対するG-CSF動員単核球細胞移植の治療効果

  福井 友章, 美舩 泰, 松本 知之, 川本 篤彦, 黒田 知也, 庄司 太郎, 黒坂 昌弘, 黒田 良祐, 浅原 孝之

  第8回日本再生医療学会, 2009


• The Efficacy of Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fracture

  Fukui T, Matsumoto T, Mifune Y, Asahara T, Kuroda R, Kurosaka M

  The 6th SICOT/SIROT Annual International Conference, 2009


• Local Transplantation of Granulocyte Colony Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells

  Fukui T, Mifune Y, Matsumoto T, Shoji T, Kuroda T, Miwa M, Kawamoto A, Asahara T, Kurosaka M, Kuroda R

  The 55th Annual Meeting of the Orthopaedic Research Society, 2009


• 骨折治療過程におけるSDF-1/CXCR4システムを介した血管内皮前駆細胞による骨・血管新生・再生の制御

  黒田 知也, 櫂 相模, 庄司 太郎, 美舩 泰, 福井 友章, 松本 知之, 松下 雄彦, 黒田 良祐, 黒坂 昌弘, 浅原 孝之

  第8回日本再生医療学会, 2009


• 大腿骨転子部骨折に対する骨接合術後にラグスクリューの近位への転位を認めた2症例

  福井 友章, 伊藤 研二郎, 松島 真司, 山田 昌弘, 吉田 和也

  第110回中部日本整形外科災害外科学会, 2008


• ボウリング中に発生した中指基節骨のsagittal split fractureの1例

  福井 友章, 伊藤 研二郎, 松島 真司, 深澤 高広, 吉田 和也

  第13回スポーツ障害フォーラム, 2008


• G-CSF動員ヒト末梢血CD34陽性細胞による偽関節治療

  美舩泰, 松本 知之, 川本 篤彦, 黒田 良祐, 庄司 太郎, 黒田 知也, 福井 友章, 三輪 雅彦, 浅原 孝之, 黒坂 昌弘

  第23回日本整形外科学会基礎学術集会, 2008


• 四肢に発生した単発性線維性腫瘍の2例

  福井 友章, 川口 洋治, 河本 旭哉, 山本 哲司

  第108回中部日本整形外科災害外科学会, 2007


• Polyostotic Fibrous Dysplasia with Epyphyseal Involvement Arising in Long Bones : A Case Report

  Fukui T, Kawaguchi Y, Kawamoto T, Kono R, Yamamoto T

  第40回 日本整形外科学会 骨・軟部腫瘍学術集会, 2007


• 当科における膝蓋骨脱臼に対するMPFL再建術の術後成績

  福井 友章, 五味 徳之, 真柴 賛, 中溝 寛之, 岩田 憲, 千頭 憲一郎, 森 諭史, 山本 哲司

  第39回中国・四国整形外科学会, 2006


• 軸椎後方要素の不連続性のために脊髄症をきたした1例

  福井 友章, 三浦 寿一, 鷲見 正敏, 笠原 孝一, 中谷 徹也, 金村 在哲, 金谷 貴子, 佐藤 啓三, 山崎 京子

  第409回整形外科集談会京阪神地方会, 2006


• 同側大腿骨に骨頭下骨折と転子部骨折を同時に発生した1例

  福井 友章, 藤田 郁夫, 西原 寛玄, 上本 晴信, 平中 崇文, 辻 充男

  第104回中部日本整形外科災害外科学会, 2005


• 大腿骨転子部骨折における整復後の遺残転位についての検討

  平中 崇文, 藤田 郁夫, 上本 晴信, 西原 寛玄, 福井 友章, 辻 充男

  第31回日本骨折治療学会, 2005


• 浅腓骨神経内に発生した intraneural ganglion の一例

  福井 友章, 平中 崇文, 西原 寛玄, 上本 晴信, 藤田 郁夫, 辻 充男

  高槻整形外科医会, 2004


• 小児に発生した舟状骨・有頭骨同時骨折の1例

  福井 友章, 藤岡 宏幸, 国分 毅, 中路 教義, 松本 知之, 黒坂 昌弘

  第398回整形外科集談会京阪神地方会, 2004

• 日本骨・関節感染症学会


• THE JAPANESE SOCIETY OF CLINICAL SPORTS MEDICINE


• The Central Japan Association of Orthopaedic Surgery and Traumatology


• JAPANESE SOCIETY FOR FRACTURE REPAIR


• THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE


• Japan Osteoporosis Society


• THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE


• THE JAPANESE ORTHOPAEDIC ASSOCIATION

• 自家組織を犠牲にしない新規骨再生療法の開発

  新倉 隆宏, 大江 啓介, 福井 友章, 澤内 健一

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025


• 炭酸ガスを利用したロコモティブシンドロームに対する新たな予防・治療法の開発

  福井 友章, 大江 啓介, 新倉 隆宏

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2025

  加齢に伴い骨粗鬆症と骨脆弱性骨折のリスクは増大する。これは閉経後の女性で顕著であり、現在骨粗鬆症に対しては薬物治療が一般的である。我々はこれまでに炭酸ガス経皮吸収が、局所組織内の酸素化、血流増加、血管新生を介し、骨折治癒の促進や破骨細胞活性の抑制効果を有する事を報告してきた。本研究の目的の一つは、卵巣摘出（OVX）ラット骨粗鬆症モデルを用いて、炭酸ガス経皮吸収システムにより骨粗鬆症の病態が改善するかを検討する事である。 12週齢の雌ラットを用い、両側OVXを施行し骨粗鬆症モデルを作成した。これらを炭酸ガス経皮吸収群、対照群の二群に分け、炭酸ガス群に対してはOVX術後翌日より炭酸ガス投与を開始する実験系（骨粗鬆症の予防を検討）と、OVX術後8週経過してから炭酸ガス投与を開始する実験系（骨粗鬆症の治療を検討）の二通りの実験系を組んだ。炭酸ガス経皮吸収は1日20分間、週5日行った。対照群に対しては同様のゲルを塗布しポリエチレン袋にて密閉するのみとした。両群において、炭酸ガス経皮吸収開始後8週マイクロCTを用いて大腿骨遠位部の骨量などのパラメータを比較した。現在、各実験系の各群において5サンプルずつの介入が終了し評価を行ったが両群間に有意差は認めていない。 また、今後の研究に密接に関わってくると考えられることから、炭酸ガス経皮吸収の至適治療時間についての検討も行っている。ラット大腿骨骨折モデルを作成し、従来の20分投与に加え、60分投与の群を設定した。頻度は上記と同じく週5日としている。骨折作成後4週までの毎週のレントゲン撮影を終了しており、順次データ解析予定である。また、同様のタイムポイントでの組織評価用のサンプル採取を完了しており、切片作製予定である。さらに、術後2・3週での骨遺伝子学的検討と免疫組織学的検討を行うためのサンプル採取と、術後4週での骨密度評価を行う予定としている。


• Bone regeneration using human induced pluripotent stem cell-derived mesenchymal stem cells

  Lee Sang Yang

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Showa University, 01 Apr. 2017 - 31 Mar. 2020

  We investigated whether implantation of chondrogenically differentiated human iPSCs-derived mesenchymal stem cells (iMSCs) could lead to bone regeneration of bone defects in mice. A 2-mm defect was created at the radius of nude mice. Chodrogenically differentiated iMSC pellets were then implanted in the defect. At week 8, 18 out of 21 (86%) radius in the treated group achieved bone healing, whereas 2 out of 11 (18%) radius in the control group achieved bone healing. At week 8, hitology revealed complete bone union in te treated group. At week 4, hypertrophic chondrocytes transitioning to the newly formed bone indicated that endochondral ossification was involved. Our results for the first time demonstrated that grafting bone defects with chondrogenically differentiated iMSCs led to successful bone regeneration through endochondoral bone ossification. Our therapy could be a novel system to repair large bone defects.

  Competitive research funding


• Application of carbon dioxide to bone regeneration therapy

  Niikura Takahiro

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2020

  It is challenging to treat intractable fracture nonunions and bone defect. Clinically available methods to treat these cases is limited and to develop a new approach is desired. The purpose of this study was to examine a hypothesis that a combined therapy of distraction osteogenesis and carbon dioxide therapy exerts synergistic or additive effects to regenerate bone. Our results of the investigation revealed that an addition of carbon dioxide therapy to distraction osteogenesis accelerated bone regeneration via up-regulation of angiogenesis and endochondral ossification compared to distraction osteogenesis alone.

  Competitive research funding


• Transcutaneous carbon dioxyde Application Accelerates Bone Fracture Healing in Diabetic Rats

  Iwakura Takashi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2020

  We created a closed transverse femoral fracture of type I diabetic rat and compared the fracture healing process between two groups (CO2 group: rats received transcutaneous carbon dioxide application / Control group: rats received sham treatment). The fracture union rates and mechanical strength were significantly higher in the CO2 group. Histologically, chondrocyte proliferation, cartilage formation, endochondral ossification, and capillary formation were significantly accelerated in the CO2 group. The gene expression levels of Collagen Ⅱ and Ⅹ, Runx2 and osterix, VFGF, and eNOS were significantly increased in the CO2 group. Our study suggested that chondrocyte proliferation, cartilage formation, endochondral ossification, bone formation, and mechanical properties, which are reported to be inhibited to cause delayed fracture healing in diabetes, may be improved by the transcutaneous carbon dioxide application, and consequently promoted fracture healing.

  Competitive research funding


• 自家末梢血CD34 陽性細胞移植 による骨・血管再生療法に関する医師主導治験

  Ryosuke Kuroda

  Japan Agency for Medical Research and Development (AMED), 再生医療実用化研究事業, Jul. 2017 - Mar. 2020

  Competitive research funding


• 骨再生療法への炭酸ガ ス経皮吸収の応用

  福井 友章

  整形災害外科学研究助成財団, 研究助成「財団奨励賞」, Apr. 2017 - Mar. 2018, Principal investigator

  Competitive research funding

• 筋萎縮抑制用組成物

  小川 渉, 平田 悠, 野村 和弘, 黒田 良祐, 新倉 隆宏, 大江 啓介, 福井 友章

  特願2021-067896, 13 Apr. 2021, 国立大学法人神戸大学, 特開2022-162858, 25 Oct. 2022

  Patent right

  IRI