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TSUJINO Yoshio
Graduate School of Science, Technology and Innovation / Department of Science, Technology and Innovation
Professor

Researcher basic information

■ Research Areas
  • Nanotechnology/Materials / Chemical biology
  • Nanotechnology/Materials / Molecular biochemistry
  • Life sciences / Applied biochemistry

Research activity information

■ Award
  • Oct. 2024 神戸大学, 令和6年度学長表彰, 財務貢献者
    辻野義雄

  • Oct. 2023 神戸大学, 令和5年度学⻑表彰, 財務貢献者
    辻野義雄

  • Oct. 2022 神戸大学, 令和4年度学⻑表彰, 財務貢献者
    辻野義雄

  • Apr. 2019 In-cosmetics 2019 Paris, Innovation Zone Best Ingredient Award 2019, Category: Functional, Finalist
    Yoshio Tsujino

  • Feb. 2019 一般財団法人 油脂工業会館, 油脂技術優秀論文賞
    辻野義雄

■ Paper
  • Kohtaro Katayama, Hiroki Hotta, Yoshio Tsujino
    Jan. 2025, Molecules2025, 30(1) (1), English
    [Refereed]
    Scientific journal

  • Bilirubin oxidase expression and activity enhancement from Myrothecium verrucaria in Aspergillus species
    Haruka Kado Horiguchi, Hironori Semba, Hiroyuki Yamada, Hirokazu Tsuboi, Takayuki Bogaki, Akio Koda, Kunishige Kataoka, Masahiro Takagi, Yoshio Tsujino
    Jul. 2024, Journal of Bioscience and Bioengineering, 138(3) (3), 212 - 217, English
    [Refereed]

  • Aromatic oil from lavender as an atopic dermatitis suppressant
    Haruna Sato, Kosuke Kato, Mayuko Koreishi, Yoshimasa Nakamura, Yoshio Tsujino, Ayano Satoh
    Jan. 2024, PLOS ONE, English
    [Refereed]
    Scientific journal

  • Yuki M Kyunai, Mika Sakamoto, Mayuko Koreishi, Yoshio Tsujino, Ayano Satoh
    GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data. The antioxidant response, protecting cells from oxidative stress, has been focused on because its activation may relieve pathological conditions, such as neurodegenerative diseases. Genes involved in the antioxidant response are defined within the GO:0006979 category, including 441 human genes. Fifteen genes overlap between the glycan biosynthesis-related genes defined by GlycoMaple and the antioxidant response genes defined by GO:0006979, one of which is FUT8. 5-Hydroxy-4-phenyl-butenolide (5H4PB) extracted from Chinese aromatic vinegar induces the expression of a series of antioxidant response genes that protect cells from oxidative stress via activation of the nuclear factor erythroid 2-related factor 2-antioxidant response element pathway. Here, we show that FUT8 is upregulated in both our RNA-seq data set of 5H4PB-treated cells and publicly available RNA-seq data set of cells treated with another antioxidant, sulforaphane. Applying our RNA-seq data set to GlycoMaple led to a prediction of an increase in the core fucose of N-glycan that was confirmed by flow cytometry using a fucose-binding lectin. These results suggest that FUT8 and core fucose expression may increase upon the antioxidant response.
    2023, PloS one, 18(2) (2), e0281516, English, International magazine
    [Refereed]
    Scientific journal

  • The Number of Electrons for the Oxidation of Caffeic Acid Depends on the Internal Volume of Electrolytic Cell
    Kenji Matsumoto, Sorai Kanno, Yuito Kitagawa, Yoshio Tsujino, Toshiyuki Osakai, Hiroki Hotta
    Jun. 2022, Journal of Flow Injection Analysis, 39(1) (1), English
    [Refereed]
    Scientific journal

  • Taichi Nagahata, Yoshio Tsujino, Eiji Takayama, Haruka Hikasa, Ayano Satoh
    Skin sensitization is an allergic reaction caused by certain chemical substances, and is an important factor to be taken into consideration when evaluating the safety of numerous types of products. Although animal testing has long been used to evaluate skin sensitization, the recent trend to regulate such testing has led to the development and use of alternative methods. Skin sensitization reactions are summarized in the form of an adverse outcome pathway consisting of four key events (KE), including covalent binding to skin proteins (KE1), keratinocyte activation (KE2), and dendritic cell activation (KE3). Equivalent alternative methods have been developed for KE1 to KE3, but no valid alternative has yet been developed for the evaluation of KE4 and T-cell activation. Current alternative methods rely on data from KE1 to KE3 to predict the effect of chemicals on skin sensitization. The addition of KE4 data is expected to improve the accuracy and reproducibility of such predictions. The aim of this study was to establish an assay to evaluate KE4 T-cell activation to supplement data on skin sensitization related to KE4. To evaluate T-cell activation, the Jurkat T-cell line stably expressing luciferase downstream of the pro-inflammatory cytokine interleukin-2 promoter was used. After exposure to known skin sensitizing agents and control substances, luciferase activity measurements revealed that this assay was valid for evaluating skin sensitization. However, two skin sensitizers known to have immunosuppressive effects on T-cells reacted negatively in this assay. The results revealed that this assay simultaneously allows for monitoring of the skin sensitization and immuno-suppressiveness of chemical substances and supplements KE4 T-cell activation data, and may thus contribute to reducing the use of animal experiments.
    Spandidos Publications, Jan. 2022, Biomedical Reports, 16(1) (1), 3 - 3, English, International magazine
    [Refereed]
    Scientific journal

  • Miyuki Miyake, Yasushi Kakizawa, Norio Tobori, Masatoshi Kurioka, Nobuhito Tabuchi, Ryo Kon, Naofumi Shimokawa, Yoshio Tsujino, Masahiro Takagi
    Elsevier BV, Sep. 2018, Colloids and Surfaces B: Biointerfaces, 169, 444 - 452
    [Refereed]
    Scientific journal

  • Unassuming softness silicone conditions hair without affecting dyes, perms of pores
    Y. Tsujino
    2018, Cosmetics & Toiletries, 133(10) (10), 46 - 56
    [Refereed]

  • Nrf2/AREシグナル伝達経路の活性化による5-ヒドロキシ-4-フェニル-ブテノライドの抗酸化効果
    田部井 陽介, 室冨 和俊, 梅野 彩, 堀江 祐範, 辻野 義雄, 桝谷 文武, 吉田 康一, 中島 芳浩
    生命科学系学会合同年次大会運営事務局, Dec. 2017, 生命科学系学会合同年次大会, 2017年度, [2P - 0485], Japanese
    [Refereed]

  • Satomi Yabuuchi, Satoshi Endo, KeangOk Baek, Kunihide Hoshino, Yoshio Tsujino, Mun'delanji C. Vestergaard, Masahiro Takagi
    Elsevier BV, Dec. 2017, Journal of Bioscience and Bioengineering, 124(6) (6), 685 - 693
    [Refereed]
    Scientific journal

  • Yosuke Tabei, Kazutoshi Murotomi, Aya Umeno, Masanori Horie, Yoshio Tsujino, Bumbu Masutani, Yasukazu Yoshida, Yoshihiro Nakajima
    5-Hydroxy-4-phenyl-butenolide (5H4PB) is a bioactive compound with antifungal and anti-obesity properties. Although it has recently been shown that 5H4PB activates peroxisome proliferator-activated receptor-gamma (PPARγ), the effect of 5H4PB on intracellular signaling pathways has not been clarified. In this study, we found that 5H4PB activated the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway, which plays an important role in cellular defense against oxidative stress, and the subsequent upregulation of ARE-dependent cytoprotective genes, including the heme oxygenase-1, catalase, and superoxide dismutase genes, without exhibiting cytotoxicity. In addition, 5H4PB significantly attenuated intracellular ROS generation, glutathione oxidation, and DNA damage induced by hydrogen peroxide (H2O2) exposure in mouse fibroblast cells. Furthermore, we demonstrated that pretreatment with 5H4PB confers a significant cytoprotective effect against H2O2-induced cell death in mouse cultured fibroblasts and primary hepatocytes. Thus, our study demonstrated that 5H4PB enhanced cellular resistance to oxidative damage via activation of the Nrf2/ARE signaling pathway.
    Elsevier BV, Sep. 2017, Food and Chemical Toxicology, 107(Pt A) (Pt A), 129 - 137, English, International magazine
    [Refereed]
    Scientific journal

  • P.Gusain, S. Ohki, K. Hoshino, Y. Tsujino, N. Shimokawa, M. Takagi
    Chirality plays a vital role in biological membranes and has a significant effect depending on the type and arrangement of the isomer. Menthol has two typical chiral forms, d- and l-, which exhibit different behaviours. l-Menthol is known for its physiological effect on sensitivity (i.e., a cooling effect), whereas d-menthol causes skin irritation. Menthol molecules may affect not only the thermoreceptors on biomembranes, but also the membrane itself. Membrane heterogeneity (lipid rafts, phase separation) depends on lipid packing and acyl chain ordering. Our interest is to elaborate the chirality dependence of d- and l-menthol on membrane heterogeneity. We revealed physical differences between the two optical isomers of menthol on membrane heterogeneity by studying model membranes using nuclear magnetic resonance and microscopic observation.
    MDPI, 2017, Membranes 2017, 7(4) (4), 69 - 82, English
    [Refereed]
    Scientific journal

  • Yoshio Tsujino

    Zhenjiang fragrant vinegar (Kozu) is a black rice vinegar that has been used as a traditional Chinese medicine and has various health benefits, including anti-obesity effects. In the present study, using luciferase reporter assays of PPARγ promoter activity, a novel ingredient from 8-year-old Kozu, 5-hydroxy-4-phenyl-butenolide, was isolated. The newly found agonist was named as "Fraglide-1". Moreover, in subsequent experiments, it was confirmed that fraglide-1 was an PPARγ agonist and it could increase expression level of the uncoupling protein (UCP)-1. Fraglide-1 was chemically synthesized and it was verified that expression of the PPARγ was increased in dose dependent manner. Although Kozu has been consumed globally as a functional food for thousands of years, the mechanisms behind its health effects have not been characterized. The active ingredient of Kozu was successfully found and the results unraveled a longtime mystery about Kozu for its beneficial health effect.

    Japan Oil Chemists' Society, 2017, Journal of Oleo Science, 66(6) (6), 615 - 622, English
    Scientific journal

  • Kaori (Otsuka) Saito, Shinji Kurose, Yoshio Tsujino, Toshiyuki Osakai, Kunishige Kataoka, Takeshi Sakurai, Eiichi Tamiya
    The flac1 gene consisted of 1488 bases encodes a novel laccase (Flac1) from Flammulina velutipes. The deduced amino acid sequence of Flac1 with 496 amino acids shows 58-64% homologies with other fungal laccases. The recombinant Flac1 (rFlac1) was heterologously expressed in Pichia pastoris, with sugars of approximately 4 kDa attached on the protein molecule, which has the calculated molecular mass of 53,532 Da. rFlac1 was shown to be a multi-copper oxidase from spectroscopies. The optimum pHs of rFlac1 for oxidations of 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), p-phenylenediamine, and o-aminophenol, were 5.0, 5.0, and 6.0-6.5, respectively, showing higher pH values than those from many other fungal laccases. The slightly acidic or neutral optimum pH that is not strongly dependent on substrates is a unique property of rFlac1. Effective O_2 reduction was realized by the direct electron transfer of rFlac1 at a highly oriented pyrolytic graphite electrode modified with fine carbon particles (Ketjen Black) in O_2-saturated solution. The pHs showing the maximum ΔE°' [E=E°'(enzyme) - E°'(substrate)] coincided well with the optimum pHs shown by rFlac1 under steady-state conditions. The present electrochemical results of rFlac1 indicate that ΔE°' is one of the primary factors to determine the activity of multi-copper oxidases.
    Elsevier BV, Feb. 2013, Journal of Bioscience and Bioengineering, 115(2) (2), 159 - 167, English
    Scientific journal

  • Kaori (Otsuka) Saito, Ryuzo Ikeda, Katsunori Endo, Yoshio Tsujino, Masahiro Takagi, Eiichi Tamiya
    Elsevier BV, May 2012, Journal of Bioscience and Bioengineering, 113(5) (5), 575 - 579
    Scientific journal

  • Tsutomu Hamada, Hideyuki Hagihara, Masamune Morita, Mun’delanji C. Vestergaard, Yoshio Tsujino, Masahiro Takagi
    American Chemical Society (ACS), Feb. 2012, The Journal of Physical Chemistry Letters, 3(3) (3), 430 - 435
    Scientific journal

  • Md. Imranul Hoq, Koji Mitsuno, Yoshio Tsujino, Takayoshi Aoki, Hisham R. Ibrahim
    Elsevier BV, Jun. 2008, International Journal of Biological Macromolecules, 42(5) (5), 468 - 477
    Scientific journal

  • Takayasu Sugihara, Tomoko Kinoshita, Shigeo Aoyagi, Yoshio Tsujino, Toshiyuki Osakai
    Elsevier BV, Jan. 2008, Journal of Electroanalytical Chemistry, 612(2) (2), 241 - 246, English
    Scientific journal

  • Kaori Otsuka, Takayasu Sugihara, Yoshio Tsujino, Toshiyuki Osakai, Eiichi Tamiya
    Elsevier BV, Nov. 2007, Analytical Biochemistry, 370(1) (1), 98 - 106
    Scientific journal

  • Hiroki Hotta, Satomi Nagano, Masashi Ueda, Yoshio Tsujino, Junko Koyama, Toshiyuki Osakai
    Elsevier BV, Aug. 2002, Biochimica et Biophysica Acta (BBA) - General Subjects, 1572(1) (1), 123 - 132
    Scientific journal

  • Hiroki Hotta, Masashi Ueda, Satomi Nagano, Yoshio Tsujino, Junko Koyama, Toshiyuki Osakai
    Elsevier BV, Apr. 2002, Analytical Biochemistry, 303(1) (1), 66 - 72
    Scientific journal

  • Hiroki Hotta, Harumi Sakamoto, Satomi Nagano, Toshiyuki Osakai, Yoshio Tsujino
    Elsevier BV, May 2001, Biochimica et Biophysica Acta (BBA) - General Subjects, 1526(2) (2), 159 - 167
    Scientific journal

  • Akiko Ogata, Yoshio Tsujino, Toshiyuki Osakai
    Royal Society of Chemistry (RSC), 2000, Physical Chemistry Chemical Physics, 2(2) (2), 247 - 251
    Scientific journal

  • J Koyama, K. Tagahara, T. Osakai, Y. Tsujino, S.Tsurumi, H. Nishino, H. Tokuda
    Elsevier BV, May 1997, Cancer Letters, 115(2) (2), 179 - 183
    Scientific journal

  • Masahiro Aoki, Yoshio Tsujino, Kenji Kano, Tokuji Ikeda
    American Chemical Society (ACS), Jan. 1996, The Journal of Organic Chemistry, 61(16) (16), 5610 - 5616
    Scientific journal

  • Yoshio Tsujino, Seiji Tsurumi, Taisaku Amakawa, Toshiyuki Osakai
    American Chemical Society (ACS), Dec. 1995, Journal of Natural Products, 58(12) (12), 1829 - 1839
    Scientific journal

  • A NEW TRITERPENOID SAPONIN (CHROMOSAPONIN-I) WITH A REDUCING POWER
    Y TSUJINO, S TSURUMI, T OSAKAI, A SAITO
    gamma-Pyronyl-triterpenoid saponin (chromosaponin I; CSI) isolated from pea is strongly adsorbed at a glassy-carbon electrode, and gives an irreversible oxidation wave at 0.4 V vs. Ag/AgCl. The gamma-pyronyl moiety is responsible for the electroactivity. CSI can reduce 1,4-benzoquinone, some of its derivatives and also cytochrome c. From comparison with other reductants, the formal redox potential of CSI was estimated to be 0.3-0.4 V vs. NHE (pH 7.0).
    CHEMICAL SOC JAPAN, Apr. 1994, CHEMISTRY LETTERS, (4) (4), 711 - 714, English
    [Refereed]
    Scientific journal

■ MISC
  • Tribology for Hair Care Using Bioconjugation Technology
    Yoshio Tsujino
    Lead, Apr. 2020, トライボロジスト, 65(4) (4), 215 - 223, Japanese

  • グリオキシル酸による酸化染料の脱色作用
    辻野義雄, 宮里朗夫, 高木昌宏
    2020, 毛髪科学, (125) (125), 43 - 46
    Introduction other

  • 3P-229 Evaluation of irritation by surfactants based on membrane dynamics
    Shimokawa Shinji, Shimokawa Naofumi, Tsujino Yoshio, Takagi Masahiro
    日本生物工学会, 2015, 日本生物工学会大会講演要旨集, 67, 328 - 328, Japanese

  • 3P-236 Effect of temperature on lipid raft and cytoskeleton of T-cell
    Okubo Yufu, Yabuuchi Satomi, Baek KeangOk, Hoshino Kunihide, Tujino Yoshio, Shimokawa Naohumi, Takagi Masahiro
    日本生物工学会, 2015, 日本生物工学会大会講演要旨集, 67, 329 - 329, Japanese

  • 2P-274 Physical changes induced by optical isomers of menthol on membrane dynamics
    Pooja Gusain, Kunihide Hoshino, Yoshio Tsujino, Naofumi Shimokawa, Masahiro Takagi
    日本生物工学会, 2015, 日本生物工学会大会講演要旨集, 67, 243 - 243, English

  • ヘアカラーの変遷と技術動向
    辻野義雄
    2015, トライポロジスト, 60(8) (8), 1 - 9
    Others

  • Variation of Skin Condition by Ingestion of Sake-condensate
    山下裕司, 山崎舞, 滝澤毅, 辻野義雄, 広常正人, 田上八朗, 坂本一民
    日本酒は日本古来のアルコール飲料として愛飲されており、適量飲酒が健康維持に役立つことが知られている。ストレス解消や血行促進は実感できる効果であり、近年では肝保護作用や美容効果も示唆されている。また、最近の研究からは日本酒に含まれる成分のエチルα-D-グルコシドが皮膚に対し整肌作用を有することが明らかにされている。本研究では日本酒からアルコールを取り除いた濃縮物に着目し、この濃縮物を配合したゼリー状飲料を摂取した時の皮膚性状の変化について被験者33名に対し臨床試験を実施した。設定した評価期間において、日本酒脱アルコール濃縮物の摂取に伴う角層水分量および経皮水分蒸散量への効果は見られなかったが、アンケート調査から肌質改善を感じたコメントが得られた。試料の味・香りから試験品とプラセボを認識したことにより、日本酒の有効成分に関する事前説明を受けた被験者は心理的効果を誘導されたと推測される。Sake is one of the favorite and traditional alcohol beverages for Japanese, and it is well known that an appropriate amount of drinking plays a role in maintaining healthy conditions. Stress release and stimulation of blood circulation by ingesting Sake is well accepted, and its effect on hepatic protection and skin condition have been recently suggested. Recent studies showed that a specific component, ethyl α-D-glucoside, contained in Sake can improve the skin condition.Therefore, the objective of present study is to clarify the effect of ingestion of the jelly combined with the Sake-condensate excluding alcohol for the skin condition. As a result, any of the effects of the Sake-condensate on the skin condition were not found, that is, the changes in the moisture content in the stratum corneum and the transepidermal water loss were almost independent on the jellys with or without the Sake-condensate during the examination period, while some subjects commented perceiving improvement of the skin condition. The taste and fl avor of the jellys might have lead the subjects to recognize the sample and placebo, to lead the subjects to perceive sample with the Sake-condensate effective to skin condition.
    千葉科学大学, 2014, 千葉科学大学紀要, 7(7) (7), 97 - 104, Japanese

  • Development of new hair dyeing techniques without hydrogen peroxide
    岡村章紀, 辻野義雄
    フレグランスジャーナル社, 2014, Fragrance journal, 42(3) (3), 17 - 22, Japanese

  • Technology to Smoothen Hair Surface with Shampoo Formulation
    辻野義雄, 上門潤一郎, 西垣祥子
    日本トライボロジー学会 ; 1989-, 2014, トライポロジスト, 59(8) (8), 477 - 483, Japanese

  • 新規ヘアカラーリング技術への挑戦
    辻野義雄
    2012, 毛髪科学, 111, 16 - 21

  • Shinji Kurose, Kunishige Kataoka, Kaori Otsuka, Yoshio Tsujino, Takeshi Sakurai
    Total and partial deletions of the region covering the substrate-binding site of the Escherichia coli cuprous oxidase, CueO evidenced that the unique specificity for cuprous ion originates in the steric hindrance to interfere the access of laccase substrates towards the type I Cu site.
    CHEMICAL SOC JAPAN, Feb. 2007, CHEMISTRY LETTERS, 36(2) (2), 232 - 233, English

  • 天然抗酸化剤クロロゲン酸の反応電子数について
    堀田 弘樹, 永野 里実, 大堺 利行, 辻野 義雄
    30 Oct. 1998, ポーラログラフィー, 44(3) (3), 117 - 117, Japanese

  • 天然抗酸化剤クロロゲン酸の電気化学的研究
    堀田 弘樹, 坂本 晴美, 大堺 利行, 辻野 義雄
    07 Nov. 1997, ポーラログラフィー, 43(3) (3), 116 - 116, Japanese

■ Books And Other Publications
  • SHINBIYO 9月号
    辻野義雄
    Contributor, ダメージの仕組みと最新ケア成分, 新美容出版株式会社, Aug. 2024

  • Hair Care Products: Cutting Edge Technology and Market Forecast
    Yoshio Tsujino
    Supervisor, シーエムシー出版, May 2023

  • 健康の科学知識 : 食事、睡眠、美容、体調・・・・・・、知って役立つ体の知識50
    辻野義雄
    Single work, pp.53-56, ニュートンプレス, Jan. 2021, Japanese, ISBN: 9784315523096

  • 体の科学知識 : 体にまつわる身近な"?"と対処法
    辻野義雄
    Single work, pp.112-115, ニュートンプレス, Dec. 2018, Japanese, ISBN: 9784315521337

  • お客様のお悩み別「美容成分」事典 経営とサイエンス
    辻野義雄, 久光一誠
    Joint work, pp.12-47, 新美容出版, 2017

  • がん患者に対するアピアランスケアの手引き
    国立がん研究センター研究開発費がん患者の外見支援に関するガイドラインの構築に向けた研究班
    Single work, CQ 37, pp.135-138,CQ 42, pp.146-148,CQ 43, pp.149-150,CQ 44, pp.151-154, 金原出版, Aug. 2016, Japanese, ISBN: 9784307702003

  • コスメティックサイエンス : 化粧品の世界を知る
    辻野義雄
    Single work, 第13章「頭髪(ヘアケア)化粧品」, 共立出版, Jun. 2014, Japanese, ISBN: 9784320061774

  • ナノ融合による先進バイオデバイス
    高木昌宏, 濱田勉, 萩原秀幸, 辻野義雄
    Joint work, 第2章 ナノバイオテクノロジー,2. 巨大リポソームの界面活性剤誘起ダイナミクス, シーエムシー出版, Nov. 2011, Japanese, ISBN: 9784781304878

■ Lectures, oral presentations, etc.
  • 加齢に伴う毛髪の用紙の変化を改善する新規ヘア素材『トステア®』とは
    辻野義雄
    第65回関西油化学講習会(油技術講座), Dec. 2024
    Public discourse

  • Melanosome Uptake and Degradation by Dermal Fibroblast Cell Line: Activation of Autophagy and Antioxidant Pathways by Resveratrol
    Ayano Satoh, Yoshio Tsujino
    日本動物実験代替法学会第37回大会, Nov. 2024
    Poster presentation

  • 天然由来成分による皮膚や毛髪へのアンチエイジング効果
    辻野義雄
    2024年日中化粧品国際交流イベント, Sep. 2024
    Public discourse

  • メタジヒドロキシベンゼン骨格の含むポリフェノールの再活性化
    菅野宙依, 塩路万葉, 北川維人, 松本健嗣, 桑原知彦, 水口仁志, 辻野義雄, 大堺利行, 堀田弘樹
    日本分析化学会第73年会, Sep. 2024
    Oral presentation

  • 光異性化した天然抗酸化剤カフェイン酸の酸化還元機構の研究
    北川維人, 菅野宙依, 松本健嗣, 辻野義雄, 堀田弘樹
    日本分析化学会第73年会, Sep. 2024
    Oral presentation

  • 髪質改善素材とアミノ酸との反応性の観察
    宮本紘幸, 片山耕太郎, 佐藤聡太郎, 松本健嗣, 田中良宜, 生田義倫, 望月祐次, 新菜摘, 堀田弘樹, 辻野義雄
    日本分析化学会第73年会, Sep. 2024
    Poster presentation

  • Myrothecium verrrucaria由来ビリルビンオキシダーゼのAspergillus属糸状菌での高生産と耐熱化
    加戸悠, 仙波弘雅, 山田尚平, 坪井宏和, 坊垣隆之, 幸田明生, 石川一彦, 森裕太郎, 荻野千秋, 高木昌宏, 辻野義雄
    第78回日本生物工学会大会
    Oral presentation

  • 界面活性剤が誘起するかゆみの評価とその抑制メカニズム
    萬代由莉恵, 安鋼, 高瀬修一, 高木昌宏, 中谷祐将, 辻野義雄, 吉村倫一
    第62回日本油化学会年会, Sep. 2024
    Poster presentation

  • Effects of Novel Amino Acid Compounds on Hair Bleaching Damage
    佐藤聡太郎, 宮本紘幸, 堀田弘樹, 生田義倫, 辻野義雄
    第49回日本香粧品学会, Jun. 2024
    Oral presentation

  • Evaluation of the hair quality improvement effect of 2-(2-aminoethylthio) succinic acid
    宮本紘幸, 田渕日奈子, 佐藤聡太郎, 片山耕太郎, 松本健嗣, 田中良宣, 生田義倫, 堀田弘樹, 辻野義雄
    第49回日本香粧品学会, Jun. 2024
    Poster presentation

  • Myrotheciyn verrucaria 由来ビリルビンオキシターゼのAspergillus属糸状菌での高生産と特性解析
    加戸悠, 仙波弘雅, 山田浩之, 坪井宏和, 坊垣隆之, 幸田明生, 片岡邦重, 高木昌弘, 辻野義雄
    日本農芸化学会2024年度大会, Mar. 2024
    Oral presentation

  • 毛髪トリートメント効果を有する有機酸とアミンの新規化合物合成
    片山耕太郎, 宮本紘幸, 望月佑次, 新菜摘, 山崎祥子, 堀田弘樹, 辻野義雄
    日本化学会第104春季年会(2024), Mar. 2024
    Oral presentation

  • 針葉樹チップ発酵熟成堆肥より得た腐植物質の抗酸化活性評価
    蔦保侑樹, 小嶋康詞, 堀田弘樹, 辻野義雄
    日本化学会第104春季年会(2024), Mar. 2024
    Oral presentation

  • 有機酸とアミンを用いた新規化合物の合成と機能性の研究
    片山耕太郎, 宮本紘幸, 堀田弘樹, 山崎祥子, 田中良宜, 辻野義雄
    日本化学会秋季事業第13回CSJフェスタ2023, Oct. 2023, Japanese
    Poster presentation

  • 有機酸-アミン複合体を用いた縮毛矯正とその毛髪の物性評価法に関する研究
    田渕日奈子, 片山耕太郎, 佐藤聡太郎, 松本健嗣, 堀田弘樹, 辻野義雄, 田中良宣, 関口博史, 井上真理, 村田長嗣
    日本分析化学会第72年会, Sep. 2023
    Oral presentation

  • 蛍光色素を用いた毛髪の表面状態の観察
    山田杏樹, 佐藤聡太郎, 堀田弘樹, 辻野義雄, 中川充, 懸橋理枝, 望月佑次
    日本分析化学会第72年会, Sep. 2023
    Oral presentation

  • Visualization and Evaluation Method for UV Cosmetics Application Using Motion Sensors
    Yoshikawa Riho, Izumi Shintaro, Terada Tsutomu, Tsujino Yoshio, Kawaguchi Hitoshi
    The 33rd IFSCC (International Federation of Societies of Cosmetic Chemists) Congress 2023 Barcelona Spain, Sep. 2023, English
    Poster presentation

  • Surfactant-induced skin delicate irritation and its evaluation by human stinging test and model membrane dynamics
    Yurie Mandai, Gang An, Shuichi Takase, Masahiro Takagi, Yusuke Nakatani, Naofumi Shimokawa, Yoshio Tsujino
    The 33rd IFSCC (International Federation of Societies of Cosmetic Chemists) Congress 2023 Barcelona Spain, Sep. 2023, English
    Poster presentation

  • Mechanistic Study of the Oxidation Reaction of Caffeic Acid Under UV Irradiation
    Yuito Kitagawa, Sorai Kanno, Kenji Matsumoto, Yoshio Tsujino, Toshiyuki Osakai, Hiroki Hotta
    The 31st International Conference on Photochemistry (ICP 2023 Sapporo Japan), Jul. 2023, English
    Poster presentation

  • 髪質改善素材の研究に関わる分析化学
    佐藤聡太郎, 片山耕太郎, 田渕日奈子, 山田杏樹, 池内亮太, 宮本紘幸, 松本健嗣, 堀田弘樹, 辻野義雄
    日本分析化学会近畿支部創設70周年記念式典, Jun. 2023
    Poster presentation

  • Surfactant-induced membrane dynamics and skin irritation
    M.Takagi, Y.Nakatani, N. Shimokawa, Y.Mandai, G.An, S.Takase, Y.Tsujino
    The 32nd IFSCC(International Federation of Societies of Cosmetic Chemists) Congress 2022, London, Sep. 2022, English
    Poster presentation

  • 産学連携のための自然科学研究における経営学~コスメティックサイエンスを例に~
    辻野義雄
    日本生物工学会中部支部若手研究者による中部支部バイオセミナーin富山, Aug. 2022
    Public discourse

  • 細胞膜模倣系を用いた界面活性剤刺激性評価
    中谷祐将, 伊藤太一, 下川直史, 萬代由梨恵, 安鋼, 高瀬修一, 辻野義雄, 高木昌宏
    日本化学会第102回春季大会, web開催, Mar. 2022

  • 有機酸ーアミン複合体を用いた新規縮毛矯正剤の開発
    田渕日奈子, 佐藤聡太郎, 堀田弘樹, 辻野義雄, 生田義倫, 田中良宣
    日本化学会第102回春季大会, web開催, Mar. 2022

  • マイクロバブルの頭髪への利用
    佐藤聡太郎, 堀田弘樹, 辻野義雄
    第12回毛髪科学研究発表会, web開催, Mar. 2022

  • システアミンー有機酸複合体を用いた髪質改善効果について
    生田義倫, 田中良宣, 辻野義雄
    第12回毛髪科学研究発表会, web開催, Mar. 2022

  • ヘアケア処方の変遷と技術動向
    辻野義雄
    第58回SCCJセミナー, Feb. 2022

  • バイオコンジュゲーション技術を用いた新しい縮毛矯正技術
    佐藤聡太郎, 堀田弘樹, 辻野義雄
    若手フロンティア研究会2021, Dec. 2021

  • Studies about membrane dynamics towards evaluation of skin irritation
    Masahiro Takagi, Naofumi Shimokawa, Yoshio Tsujio
    The International Chemical Congress of Pacific Basin Socienties 2021 (Pacifichem 2021), Dec. 2021, English

  • カフェイン酸のクーロメトリー検出における電解セル依存性について
    菅野宙依, 松本健嗣, 辻野義雄, 大堺利行, 堀田弘樹
    第67回ポーラログラフィーおよび電気分析化学討論会、web開催, Nov. 2021

  • 香醋由来の機能性成分“フレグライド1”によるスカルプケアへのアプローチ
    辻野義雄
    第12回毛髪技術者協会「毛髪科学研究発表会」, Nov. 2021
    [Invited]

  • ヘアカラーリングにおけるポリマーの活用
    辻野義雄
    第30回ポリマー材料フォーラム(主催:高分子学会), Nov. 2021
    [Invited]

  • 糸状菌における撹拌翼形状とタンパク質生産分泌生産の相関解析
    小野太暉, 鈴木智大, 加戸悠, 坪井宏和, 坊垣隆之, 幸田明夫, 辻野義雄, 近藤昭彦, 荻野千秋
    第73回日本生物工学会, Oct. 2021

  • イオンドライヤーが毛髪に与える効果の評価
    佐藤聡太朗, 堀田弘樹, 中川充, 懸橋理枝, 戸塚広乃, 日野祥子, 辻野義雄
    日本分析学会第70年会, Sep. 2021

  • 糸状菌を用いた外来性酸化還元酵素の分泌生産性の解析
    小野太暉, 近藤昭彦, 荻野千秋, 櫻川拓, 辻野義雄, 仙波弘雅, 坪井宏和, 坊垣隆之
    第23回化学工学会学生発表会, Mar. 2021

  • アトピー性皮膚炎惹起性の評価のための動物実験代替法の確立
    加藤浩介, 辻野義雄, 佐藤あやの
    日本動物実験代替法学会第33回大会, Nov. 2020

  • アトピー性皮膚炎惹起性評価のための試験法の確立
    加藤浩介, 辻野義雄, 佐藤あやの
    日本生物工学会西日本支部大会2020(第5回講演会), 2020

  • Visualization of Physiological Responses Using Membrane Dynamics of Cell-Sized Liposome
    M. Takagi, N. Shimokawa, Y. Tsujino
    IFSCC (International Federation of Societies of Cosmetic Chemists) Congress 2020 Yokohama, 2020

  • 細胞模倣膜を用いた界面活性剤刺激性評価に関する研究
    藤根志帆, 佐々木陽介, 下川直史, 辻野義雄, 高木昌宏
    第71回日本生物工学会大会, Sep. 2019

  • 細胞模倣膜ダイナミクスに基づく界面活性剤の分子構造と刺激性の相関性
    藤根志帆, 佐々木陽介, 辻野義雄, 下川直史, 高木昌宏
    第13回バイオ関連化学シンポジウム, 2019

  • 生体模倣膜ダイナミクスにおける界面活性剤の親水性・疎水性バランスの影響
    佐々木陽介, 辻野義雄, 下川直史, 高木昌宏
    日本化学会第99春季年会, Mar. 2019

  • Dynamics of biomimetic membranes induced by low irritating surafactants
    M. Takagi, N. Shimokawa, Y. Tsujino
    IFSCC (International Federation of Societies of Cosmetic Chemist) Congress 2019 Milan, 2019

  • 細胞模倣膜ダイナミクス解析に基づく界面活性剤の分子構造と刺激性の相関性
    藤根志帆, 佐々木陽介, 下川直史, 辻野義雄, 高木昌宏
    日本化学会令和元年度北陸地区講演会と研究発表会, 2019

  • 分子構造が似た界面活性剤が引き起こす生体模倣膜の変形ダイナミクス
    佐々木陽介, 辻野義雄, 下川直史, 高木昌宏
    日本化学会平成30年度北陸地区講演会と研究発表会, Nov. 2018

  • 紫外線ストレス状態モデル膜と低刺激性界面活性剤の相互作用
    高橋祐菜, 辻野義雄, 下川直史, 高木昌宏
    日本化学会平成30年度北陸地区講演会と研究発表会, Nov. 2018

  • 生体模倣膜と低刺激性界面活性剤の相互作用
    佐々木陽介, 辻野義雄, 下川直史, 高木昌宏
    日本化学会 第12回バイオ関連化学シンポジウム, Sep. 2018

  • ストレス状態モデル膜と低刺激性界面活性剤の相互作用
    高橋祐菜, 辻野義雄, 下川直史, 高木昌宏
    第70回日本生物工学会大会, Sep. 2018

  • 分子構造が似た界面活性剤が引き起こす生体模倣膜の変形ダイナミクス
    佐々木陽介, 辻野義雄, 下川直史, 高木昌宏
    第70回日本生物工学会大会, 2018

  • Chirality-dependent Interaction of d- and l-menthol with biomembrane models
    M. Takagi, N. Shimokawa, P. Gussan, S. Ohki, K. Hoshino, Y. Tsujino
    IFSCC (International Federation of Societies of Cosmetic Chemists) Congress 2018 Munich, 2018

  • Evaluation for skin irritation based on surfactant-induced membrane dynamics
    M. Takagi, S. Shimokawa, N. Shimokawa, Y. Tsujino
    IFSCC (The International Federation of Societies of Cosmetic Chemists) 2016 Congress, Orlando-Florida, 2016

  • Difference in membrane dynamics induced by d- and l-methol
    P. Gussan, K. Hoshino, Y. Tsujino, M. Takagi
    57th International Conference on the Bioscience of Lipids, Chamonix- Mont Blanc, France, 2016

  • Membrane fluidity and cell signal transduction: Effect of menthol on cell membrane
    M.Takagi, S. Yabuuchi, N. Shimokawa, K. Hoshino, Y. Tsujino
    2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015), Honolulu, 2015

  • Effects of a newly found active ingredient, Fraglidel, in Zhenjiang vinegar, on a model mouse of dietary obesity
    Y. Tsujino, M. Takagi, Y. Yoshida, N. Gotoh, A. Satoh
    2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015), Honolulu, 2015

  • 8年熟成香醋に認められた抗肥満活性成分:フレグライド1
    辻野義雄, 高木昌宏, 後藤直宏
    第67回日本生物工学会大会, 2015

  • 中国伝統調味料「香醋」の有効成分を発見 ~有効成分”Fraglide-1”の効果について~
    辻野義雄
    平成27年北陸ライフケアセミナー, 2015
    [Invited]

  • シャンプー製剤によるコンディショニング機能とその頭皮への影響
    辻野義雄
    日本毛髪技術協会 第56回全国セミナー, 2015
    [Invited]

  • 最新コスメティックサイエンスと化粧品業界の企業動向
    辻野義雄
    化学生命工学特別セミナー, 2014
    [Invited]

  • 天然の黒色色素であるメラニン、その前駆体の酸化酵素誘導による発色反応の意義
    辻野義雄
    健康工学研究部門セミナー, 2013

■ Affiliated Academic Society
  • 日本農芸化学会
    Mar. 2024 - Present

  • 毛髪科学技術者協会
    - Present

  • 日本化粧医療学会
    - Present

  • 日本分析化学会
    - Present

  • 日本動物実験法学会
    - Present

  • 日本油化学会
    - Present

  • 日本化学会
    - Present

  • 日本生物工学会
    - Present

  • 日本化粧品技術者会
    - Present

■ Media Coverage
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