Research activity information

• Cytotoxicity of allyl isothiocyanate and its metabolites in hepatocellular carcinoma HepG2 cells

  Takashi Hashimoto, Shino Nakamura, Takeshi Suzuki, Yuka Hasegawa, Kazuki Kanazawa

  Elsevier BV, Feb. 2025, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 830, 111899 - 111899, English, Password protected

  [Refereed]

  Scientific journal

  添付ファイルのURL


• Anti‐Malarial Activity of Allyl Isothiocyanate and N‐acetyl‐S‐(N‐allylthiocarbamoyl)‐l‐Cysteine

  Takashi Hashimoto, Shoji Yoshioka, Shiroh Iwanaga, Kazuki Kanazawa

  Scope Malaria remains one of the most important infectious diseases in the world. Allyl isothiocyanate (AITC) is a main ingredient of traditional spice Wasabia japonica, which is reported to have anti‐bacterial and antiparasitic activities. However, there is no information on effects of AITC against malaria. The present study investigates the anti‐malarial activity of dietary AITC in vivo and that of AITC metabolites in vitro. Methods and results The ad libitum administration of 35, 175, or 350 µM AITC‐containing drinking water to ICR mice significantly inhibit the parasitemia induced after infection with Plasmodium berghei. On the other hand, after single oral administration of AITC (20 mg kg⁻¹ body weight), N‐acetyl‐S‐(N‐allylthiocarbamoyl)‐l‐cysteine (NAC‐AITC) as one of the AITC metabolites displays a serum C_max of 11.4 µM at a T_max of 0.5 h, but AITC is not detected at any time point. Moreover, NAC‐AITC shows anti‐malarial activity against Plasmodium falciparum in vitro, and its 50% inhibitory concentration (IC₅₀) against parasitemia is 12.6 µM. Conclusions These results indicate that orally administered AITC is metabolized to NAC‐AITC and exerts anti‐malarial activity against malaria parasites in blood, suggesting that the consumption of AITC‐containing food stuffs such as cruciferous plants may prevent malaria.

  Wiley, Sep. 2023, Molecular Nutrition & Food Research, 67(21) (21), English

  [Refereed]

  Scientific journal


• Dietary isosaponarin is intestinally metabolized to isovitexin, most of which are excreted in feces without being absorbed.

  Takashi Hashimoto, Jiansheng Long, Kazuki Kanazawa

  Mar. 2023, Asian Journal of Food Research and Nutrition, 2(3) (3), 12 - 24, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Protective effect of Boysenberry Juice on Ferric Nitrilotriacetate-induced Renal Injury in Mice

  Takashi Hashimoto, Maki Kiyota, Kazuki Kanazawa

  Boysenberry (Rubus loganbaccus × baileyanus Britt.) is one of the popular berries in Western countries. In the present study, the effect of the boysenberry juice on ferric nitrilotriacetate (Fe-NTA)-induced renal injury was investigated. ICR mice (7 weeks old, male) were ad libitum administered boysenberry juice for 1 week, and were intraperitoneally injected Fe-NTA (5 mg Fe/kg body weight) as an oxidant to renal. The consumption of boysenberry juice suppressed the Fe-NTA-increased thiobarbituric acid reactive substances (TBARS) in kidney and blood urea nitrogen (BUN). These results indicate that the consumption of boysenberry juice reduces the risk of oxidative stress.

  Sciencedomain International, Jul. 2021, European Journal of Medicinal Plants, 32(4) (4), 76 - 81, English

  [Refereed]

  Scientific journal


• 6-Methylsulfinylhexyl Isothiocyanate Inhibits Cell Cycle Progression in Quiescent Jb6 Cells Stimulated with Epidermal Growth Factor

  Takashi Hashimoto, Maki Kobayashi, Kazuki Kanazawa

  Objective: The effects of 6-MSITC on cell cycle progression were investigated in quiescent mouse epidermal JB6 cells. Background: 6-Methylsulfinylhexyl isothiocyanate (6-MSITC) derived from wasabi (Wasabia japonica) has been reported to prevent tumor development in vivo. Material and methods: Treatment with epidermal growth factor (EGF) to quiescent JB6 cells, which were serum-starved for 36 h, promoted cell cycle progression from the G0/G1 phase to the S phase. Effects of pretreatment with 6-MSITC on cell cycle progression were estimated by flowcytometry and real-time RT-PCR. Results: Pretreatment with 6-MSITC at 0.25-1.0 μg/ml prior to the growth stimulation with EGF significantly inhibited cell cycle progression. Pretreatment with 6-MSITC inhibited the gene expression of DNA synthesis-related proteins cyclin A2, dumbbell former 4, and proliferating cell nuclear antigen. Conclusion: These results showed that 6-MSITC inhibits cell cycle progression in quiescent cells, accompanied by the inhibition of gene expression of DNA synthesis proteins.

  Sciencedomain International, Jun. 2021, Annual Research & Review in Biology, 36(6) (6), 19 - 28, English

  [Refereed]

  Scientific journal


• Artepillin C Inhibits Cell Proliferation by Cell Cycle Arrest at G0/G1 Phase Accompanied by Up-Regulation of p27Kip1 in Human Hepatoma HepG2 Cells

  Takashi Hashimoto, Weitao Shang, Kazuki Kanazawa

  Artepillin C, 3, 5-diprenyl-4-hydroxycinnamic acid, is one of the bioactive constituents in Brazilian propolis. In the present study, the anticarcinogenic activity of this compound was investigated in human hepatoma HepG2 cells. Artepillin C inhibited the cell proliferation in a dose- and time-dependent manner accompanied by G0/G1 phase arrest in the cell cycle. This compound caused a decrease in the phosphorylation levels of the retinoblastoma protein at Ser780 and Ser807/811 and a decrease in the kinase activity of the cyclinD and CDK4 complex without any change in these protein levels. Artepillin C increased the protein level of p27Kip1, known as a CDK inhibitor. This up-regulation was regulated by both the transcriptional and post-transcriptional levels, i.e., the treatment increased the mRNA of p27Kip1 and decreased the proteosome activity. Thus, artepillin C induces cell cycle arrest at G0/G1 phase accompanied by up-regulation of p27Kip1, resulting in the inhibition of cell proliferation in HepG2 cells. This study suggested that artepillin C will be a promising anti-cancer agent against hepatoma cancer.

  Sciencedomain International, May 2021, Journal of Complementary and Alternative Medical Research, 30 - 43, English

  [Refereed]

  Scientific journal


• Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1

  Noriyuki Mori, Manami Kurata, Hanae Yamazaki, Shigenobu Matsumura, Takashi Hashimoto, Kazuki Kanazawa, Tomonori Nadamoto, Kazuo Inoue, Tohru Fushiki

  Japan Society for Bioscience Biotechnology and Agrochemistry, 2018, Bioscience, Biotechnology and Biochemistry, 82(4) (4), 698 - 708, English

  [Refereed]

  Scientific journal


• Hot Water Extract of Grifola gargal Possesses Anti-inflammatory Activity

  Masashi Mizuno, Iwao Sakane, Ken-ichiro Minato, Junya Watanabe, Takashi Hashimoto

  Sep. 2017, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 23(5) (5), 725 - 732, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice

  Takashi Kuwata, Takashi Hashimoto, Nobuaki Ohto, Hiroshige Kuwahara, Jae Won Lee, Takeshi Bamba, Masashi Mizuno

  Mar. 2017, JOURNAL OF FUNCTIONAL FOODS, 30, 228 - 236, English

  [Refereed]

  Scientific journal


• Enhancement of anti-inflammatory and anti-allergic activities with combination of luteolin and quercetin in in vitro co-culture system

  MIZUNO MASASHI, YAMASHITA SAE, HASHIMOTO TAKASHI

  2017, Food Science and Technology Research, 23(6) (6), 811 - 818, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity

  Yuka Tanino, Takashi Hashimoto, Takao Ojima, Masashi Mizuno

  Jul. 2016, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(1) (1), 25 - 30, English

  [Refereed]

  Scientific journal


• Lipid peroxides as endogenous oxidants forming 8-oxo-guanosine and lipid-soluble antioxidants as suppressing agents

  Kazuki Kanazawa, Miku Sakamoto, Ko Kanazawa, Yoriko Ishigaki, Yoshiko Aihara, Takashi Hashimoto, Masashi Mizuno

  Jul. 2016, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 59(1) (1), 16 - 24, English

  [Refereed]

  Scientific journal


• A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine

  YAMASHITA SAE, YOKOYAMA YUKI, HASHIMOTO TAKASHI, MIZUNO MASASHI

  Elsevier, Apr. 2016, Journal of Immunological Method, English

  [Refereed]

  Scientific journal


• (-)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones

  Won-Young Song, Yoshiko Aihara, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno

  Sep. 2015, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 57(2) (2), 164 - 169, English

  [Refereed]

  Scientific journal


• Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects.

  Rendong Ren, Yosuke Azuma, Takao Ojima, Takashi Hashimoto, Masashi Mizuno, Yosuke Nishitani, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa

  Laminaria japonica is traditionally eaten in Japan as a beneficial food for thrombosis. The alga contains two specific ingredients, a xanthophyll fucoxanthin (FX) and a polysaccharide, F-fucoidan (FD). The aim of the present study was to investigate whether FX or FD exhibited anti-thrombotic effects. For this purpose, three types of capsules, containing 1 mg FX, 400 mg fucoidan, and both, were prepared from the alga and administered to volunteers for 5 weeks. The dose of FD or FD+FX significantly shortened lysis time (LT) of the thrombus measured by a global thrombosis test in the blood, but FX did not. Examining the mechanism, dietary FD increased H2O2 and the secretion of prostacyclin (PGI2), a potent inhibitor of platelet aggregation, in the blood, although FD was under the detection limit in the blood, determining with its monoclonal antibody. Furthermore, in mouse experiments, dietary FD was totally excreted into the faeces and was not incorporated into the blood. We then employed a co-culture system of a Caco-2 cell monolayer with fresh human blood. The addition of FD to Caco-2 cells stimulated the expression of NADPH oxidase 1 (NOX1) and dual oxidase 2 (DUOX2) mRNA and secreted H2O2 onto the blood side accompanied by a significant increase in serum PGI2 production. These effects were invalidated by the combined addition of FD with its monoclonal antibody. The results suggested that dietary FD stimulated the expression of H2O2-producing enzymes in intestinal epithelial cells and released H2O2 into the blood, which played a signalling role to increase PGI2 production and then shortened LT for thrombi.

  Sep. 2013, The British journal of nutrition, 110(5) (5), 880 - 90, English, International magazine

  [Refereed]

  Scientific journal


• Intestinal anti-inflammatory activity of luteolin: role of the aglycone in NF-kappa B inactivation in macrophages co-cultured with intestinal epithelial cells

  Yosuke Nishitani, Koji Yamamoto, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa, Takashi Hashimoto, Masashi Mizuno

  Sep. 2013, BIOFACTORS, 39(5) (5), 522 - 533, English

  [Refereed]

  Scientific journal


• Intestinal Anti-Inflammatory Activity of Lentinan: Influence on IL-8 and TNFR1 Expression in Intestinal Epithelial Cells

  Yosuke Nishitani, Ling Zhang, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa, Takashi Hashimoto, Masashi Mizuno

  Apr. 2013, PLOS ONE, 8(4) (4), English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood

  REN Rendong, HASHIMOTO TAKASHI, MIZUNO Masashi, TAKIGAWA Hirosato, YOSHIDA Masaru, AZUMA Takeshi, KANAZAWA Kazuki

  Mar. 2013, Journal of Clinical Biochemistry and Nutrition, 52(3) (3), 228 - 233, English

  [Refereed]

  Scientific journal


• Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract.

  Takashi Hashimoto, Yoshiaki Ozaki, Masashi Mizuno, Masaru Yoshida, Yosuke Nishitani, Takeshi Azuma, Akitoshi Komoto, Takashi Maoka, Yuka Tanino, Kazuki Kanazawa

  Dietary fucoxanthin has been reported to exert several physiological functions, and fucoxanthinol is considered to be the primary active metabolite of fucoxanthin. However, there is no information about the pharmacokinetics of fucoxanthinol in human subjects. In the present study, eighteen human volunteers were orally administered kombu extract containing 31 mg fucoxanthin, and their peripheral blood was collected 5 min before and 0·5, 1, 2, 4, 8 and 24 h after the treatment. Plasma fucoxanthinol concentrations were measured by HPLC, and the pharmacokinetics of fucoxanthinol were as follows: maximum concentration, 44·2 nmol/l; time at maximum concentration, 4 h; terminal half-time, 7·0 h; area under the curve (AUC) for 1-24 h, 578·7 nmol/l × h; AUC(∞), 663·7 nmol/l × h. In addition to fucoxanthinol, we also attempted to detect amarouciaxanthin A, a hepatic metabolite of fucoxanthinol, using HPLC, but it was not present in the volunteers' plasma. On the other hand, a peak that was suspected to represent the cis-isomer of fucoxanthinol was found in the HPLC chromatogram. By comparing the present results with those of a previous study using mice, we found that the bioavailability and metabolism of fucoxanthinol differ between human subjects and mice.

  Jun. 2012, The British journal of nutrition, 107(11) (11), 1566 - 9, English, International magazine

  [Refereed]

  Scientific journal


• Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice.

  Go Bouike, Yosuke Nishitani, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno

  To clarify the mechanism of the antiallergic activity of Agaricus blazei Murill extract (ABME), the present paper used an in vivo allergy model and an in vitro intestinal gut model. During OVA sensitization, the serum IgE levels decreased significantly in ABME group. Interleukin (IL)-4 and -5 produced from OVA-restimulated splenocytes was significantly decreased, and anti-CD3ε/CD28 antibody treatment also reduced IL-10, -4, and -5 production and increased IFN-γ production in ABME group. These results suggest that oral administration of ABME improves Th1/Th2 balance. Moreover, a coculture system constructed of Caco-2 cells and splenocytes from OT-II mice or RAW 264.7 cells indicated that the significant increases in IFN-γ production by ABME treatment. Therefore, it was concluded that the antiallergic activity of ABME was due to the activation of macrophages by epithelial cells and the promotion of the differentiation of naïve T cells into Th1 cells in the immune.

  2011, Evidence-based complementary and alternative medicine : eCAM, 2011(. pii) (. pii), 532180, English, International magazine

  [Refereed]

  Scientific journal


• Fucoxanthin Induces Apoptosis in Osteoclast-like Cells Differentiated from RAW264.7 Cells

  Swadesh K. Das, Rendong Ren, Takashi Hashimoto, Kazuki Kanazawa

  May 2010, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 58(10) (10), 6090 - 6095, English

  [Refereed]

  Scientific journal


• Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation

  Masashi Mizuno, Yosuke Nishitani, Takashi Hashimoto, Kazuki Kanazawa

  Oct. 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73(10) (10), 2324 - 2325, English

  [Refereed]

  Scientific journal


• The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice

  Takashi Hashimoto, Yoshiaki Ozaki, Mayuko Taminato, Swadesh K. Das, Masashi Mizuno, Kazuto Yoshimura, Takashi Maoka, Kazuki Kanazawa

  Jul. 2009, BRITISH JOURNAL OF NUTRITION, 102(2) (2), 242 - 248, English

  [Refereed]

  Scientific journal


• Quantification and Localization of Fucoidan in Laminaria japonica Using a Novel Antibody

  Masashi Mizuno, Yosuke Nishitani, Takeshi Tanoue, Yoshie Matoba, Taka Ojima, Takashi Hashimoto, Kazuki Kanazawa

  Feb. 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73(2) (2), 335 - 338, English

  [Refereed]

  Scientific journal


• A formation mechanism for 8-hydroxy-2 '-deoxyguanosine mediated by peroxidized 2 '-deoxythymidine

  Miho Goto, Keisuke Ueda, Takashi Hashimoto, Shinji Fujiwara, Kayo Matsuyama, Takashi Kometani, Kazuki Kanazawa

  Nov. 2008, FREE RADICAL BIOLOGY AND MEDICINE, 45(9) (9), 1318 - 1325, English

  [Refereed]

  Scientific journal


• A possible mechanism that flavonoids exert anticarcinogenesis with activation of β-glucuronidase in cancerous tissues

  Naomi Oi, Takashi Hashimoto, Kazuki Kanazawa

  American Chemical Society, Sep. 2008, ACS Symposium Series, 993, 102 - 107, English

  International conference proceedings


• In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells

  Takeshi Tanoue, Yosuke Nishitani, Kazuki Kanazawa, Takashi Hashimoto, Masashi Mizuno

  Sep. 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 374(3) (3), 565 - 569, English

  [Refereed]

  Scientific journal


• Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D

  Swadesh K. Das, Takashi Hashimoto, Kazuki Kanazawa

  Apr. 2008, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1780(4) (4), 743 - 749, English

  [Refereed]

  Scientific journal


• Metabolic conversion of dietary quercetin from its conjugate to active aglycone following the induction of hepatocarcinogenesis in fisher 344 rats

  Naomi Oi, Takashi Hashimoto, Kazuki Kanazawa

  Jan. 2008, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56(2) (2), 577 - 583, English

  [Refereed]

  Scientific journal


• Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes

  Hideo Nakabayashi, Takashi Hashimoto, Hitoshi Ashida, Shin Nishiumi, Kazuki Kanazawa

  2008, BIOFACTORS, 34(4) (4), 293 - 302, English

  [Refereed]

  Scientific journal


• Yellow tea is more potent than other types of tea in suppressing liver toxicity induced by carbon tetrachloride in rats

  Takashi Hashimoto, Miho Goto, Hiroyuki Sakakibara, Naomi Oi, Maymni Okamoto, Kazuki Kanazawa

  Jul. 2007, PHYTOTHERAPY RESEARCH, 21(7) (7), 668 - 670, English

  [Refereed]

  Scientific journal


• Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells

  Kazuki Kanazawa, Mari Uehara, Hiroaki Yanagitani, Takashi Hashimoto

  Nov. 2006, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 455(2) (2), 197 - 203, English

  [Refereed]

  Scientific journal


• Japanese kelp (Kombu) extract suppressed the formation of aberrant crypt foci in azoxymethane challenged mouse colon

  DAS K. Swadesh, HASHIMOTO Takashi, BABA Masaki, NISHINO Hoyuki, KOMOTO Akitoshi, KANAZAWA Kazuki

  Feb. 2006, Journal of Clinical Biochemistry and Nutrition, Vol. 38, No. 2, pp.119-125, 119 - 125, English

  [Refereed]

  Scientific journal


• Development of a method to remove cyanogen glycosides from flaxseed meal

  YAMASHITA Takatoshi, SANO Takashi, HASHIMOTO Takashi, KANAZAWA Kazuki

  2006, International Journal of Food Science and Technology, 42(1): 70-75, English

  [Refereed]

  Scientific journal


• Comparative study of antioxidative activity among the Six Great Chinese teas; green, white, yellow, oolong, black, and pu-erh teas

  HASHIMOTO Takashi, OI Naomi, SAKAKIBARA Hiroyuki, GOTO Miho, KANAZAWA Kazuki

  2006, ITE Letters on Batteries, New Technologies & Medicine, Vol. 7, No. 5, pp. 484-487, English

  [Refereed]

  Scientific journal


• Effects of combined administration of quercetin, rutin, and extract of white radish sprout rich in kaempferol glycosides on the metabolism in rats

  T Hashimoto, Y Ueda, N Oi, H Sakakibara, C Piao, H Ashida, M Goto, K Kanazawa

  Jan. 2006, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 70(1) (1), 279 - 281, English

  [Refereed]

  Scientific journal


• A frequent drinking of green tea lowers the levels of endogenous oxidative stress in small intestines, erythrocytes and kidneys in rats

  SAKAKIBARA Hiroyuki, ASHIDA Hitoshi, FUKUDA Itsuko, FURUYASHIKI Takashi, SANO Takashi, NONAKA Yuji, HASHIMOTO Takashi, KANAZAWA Kazuki

  Jan. 2006, Journal of Clinical Biochemistry and Nutrition, Vol. 39, No. 1, pp. 32-39, English

  [Refereed]

  Scientific journal


• Artepillin C in Brazilian propolis induces G(0)/G(1) arrest via stimulation of Cip1/p21 expression in human colon cancer cells

  K Shimizu, SK Das, T Hashimoto, Y Sowa, T Yoshida, T Saka, Y Matsuura, K Kanazawa

  Dec. 2005, MOLECULAR CARCINOGENESIS, 44(4) (4), 293 - 299, English

  [Refereed]

  Scientific journal


• Fucoxanthin induces cell cycle arrest at G(0)/G(1) phase in human colon carcinoma cells through up-regulation of p21(WAF1/Cip1)

  SK Das, T Hashimoto, K Shimizu, T Yoshida, T Sakai, Y Sowa, A Komoto, K Kanazawa

  Nov. 2005, BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1726(3) (3), 328 - 335, English

  [Refereed]

  Scientific journal


• Suppressive effects of catechins on differentiation of 3T3-L1 preadipocytes

  AOKI Y, HASHIMOTO Takashi, YOSHIDA K, ASHIDA Hitoshi

  Mar. 2005, Proceedings of 2004 International Conference on O-CHA(tea) Culture and Science, 547-548, English

  International conference proceedings


• Protective effects of Chinesetea on carbon tetrachloroide-induced liver injury

  GOTO Miho, HASHIMOTO Takashi, FUKUDA Shinya, NOBUCHI Midori, PIAO C, SHANG W, NAMBA Rie, LU Y, KANAZAWA Kazuki

  2005, Proceedings of 2004 International Conference on O-CHA(tea) Culture and Science, 617-618, English

  [Refereed]

  International conference proceedings


• Protective effect of green tea on etoposide-induced apoptosis in rat thymocytes

  HASHIMOTO Takashi, ITO C, KANAZAWA Kazuki, ASHIDA Hitoshi

  2005, Proceedings of 2004 International Conference on O-CHA(tea) Culture and Science, 479-480, English

  International conference proceedings


• Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPAR gamma 2 and C/EBP alpha in 3T3-L1 cells

  T Furuyashiki, H Nagayasu, Y Aoki, H Bessho, T Hashimoto, K Kanazawa, H Ashida

  Nov. 2004, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(11) (11), 2353 - 2359, English

  [Refereed]

  Scientific journal


• Caffeine inhibits cell proliferation by G(0)/G(1) phase arrest in JB6 cells

  T Hashimoto, ZW He, WY Ma, PC Schmid, AM Bode, CS Yang, Z Dong

  May 2004, CANCER RESEARCH, 64(9) (9), 3344 - 3349, English

  [Refereed]

  Scientific journal


• 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes

  T Hashimoto, T Sano, W Ito, K Kanazawa, GI Danno, H Ashida

  Apr. 2004, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(4) (4), 964 - 967, English

  Scientific journal


• Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver.

  OKAMOTO T, KODOI R, NONAKA Y, FUKUDA Itusko, HASHIMOTO T, KANAZAWA Kazuki, MIZUNO Masashi, ASHIDA Hitoshi

  2004, BioFactors, 21, 407-409, English

  Scientific journal


• Green tea extract inhibits etoposide-induced apoptosis in rat thymocytes.

  HASHIMOTO T, FUKUSHIMA W, ITO W, TAKAGI M, KANAZAWA Kazuki, ASHIDA Hitoshi

  2004, ITE Letters on Batteries, New Technology & Medicine., 5(1) 73-78, English

  Scientific journal


• Anti-obesity actions of green tea: Possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis-related transcription factors

  H Ashida, T Furuyashiki, H Nagayasu, H Bessho, H Sakakibara, T Hashimoto, K Kanazawa

  2004, BIOFACTORS, 22(1-4) (1-4), 135 - 140, English

  [Refereed]

  Scientific journal


• Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways

  ZW He, WY Ma, T Hashimoto, AM Bode, CS Yang, ZG Dong

  Aug. 2003, CANCER RESEARCH, 63(15) (15), 4396 - 4401, English

  [Refereed]

  Scientific journal


• Suppression of cytochrome P4501 a subfamily in mouse liver by oral intake of polysaccharides from mushrooms, Lentinus edodes and Agaricus blazei

  H Ashida, T Hashimoto, Y Nonaka, Fukuda, I, K Kanazawa, G Danno, K Minato, S Kawakami, M Mizuno

  2003, FOOD FACTORS IN HEALTH PROMOTION AND DISEASE PREVENTION, 851, 235 - 248, English

  [Refereed]

  Scientific journal


• Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice

  T Hashimoto, Y Nonaka, K Minato, S Kawakami, M Mizuno, Fukuda, I, K Kanazawa, H Ashida

  Jul. 2002, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(7) (7), 1610 - 1614, English

  [Refereed]

  Scientific journal


• Apoptosis in the thymus after intraperitoneal injection of rats with Trp-P-1

  T Hashimoto, T Furuyashiki, T Sano, K Kihara, Fukuda, I, W Ito, P Park, K Kanazawa, G Danno, H Ashida

  2002, ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 40(3) (3), 175 - 183, English

  [Refereed]

  Scientific journal


• The heterocyclic amine, 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells

  H Ashida, K Kihara, Y Nonaka, Fukuda, I, B Shiotani, T Hashimoto

  Nov. 2001, TOXICOLOGY AND APPLIED PHARMACOLOGY, 177(1) (1), 59 - 67, English

  [Refereed]

  Scientific journal


• 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces caspase-dependent apoptosis in mononuclear cells

  T Hashimoto, H Ashida, T Sano, T Furuyashiki, Y Hatanaka, K Minato, M Mizuno, K Nomura, A Kumatori, K Kanazawa, G Danno

  May 2001, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1539(1-2) (1-2), 44 - 57, English

  [Refereed]

  Scientific journal


• DNA-damaging carcinogen 3-amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) induces apoptosis via caspase-9 in primary cultured rat hepatocytes

  B Shiotani, Y Nonaka, T Hashimoto, K Kihara, K Kanazawa, G Danno, H Ashida

  May 2001, CARCINOGENESIS, 22(5) (5), 693 - 700, English

  [Refereed]

  Scientific journal


• 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) induces apoptosis in rat splenocytes and thymocytes by different mechanisms

  T Hashimoto, H Ashida, T Sano, T Furuyashiki, B Shiotani, K Kanazawa, G Danno

  Dec. 2000, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 457(1-2) (1-2), 57 - 67, English

  [Refereed]

  Scientific journal


• Synergistic Effects of Food Colors on the Toxicity of 3-Amino-1, 4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) in Primary Cultured Rat Hepatocytes

  ASHIDA Hitoshi, HASHIMOTO Takashi, TSUJI Shinji, KANAZAWA Kazuki, DANNNO Gen-ichi

  The synergistic effect of food additives or food colors on the toxicity of 3-amino-l, 4-dimethyl-5H-pyrido[4, 3-b]indole (Trp-P-1) was investigated using primary cul-tured rat hepatocytes. When hepatocytes from rats fed a standard diet were treated with a mixture of four major food additives (sorbitol, sodium L(+)-glutamate, benzoic acid, and propylene glycol) or a mixture of six typical artificial food colors (erythrosine, allura red, new coccine, brilliant blue, tertrazine, and fast green), the in vitro treated food-color mix-ture itself showed cytotoxicity; the reduction of cell viability and decreases in the activities of gluconeogenesis and ureogenesis. The food-color mixture enhanced cytotoxicity of Trp-P-1 obviously. We then investigated the effects of in vivo-dosed food additives or food colors on Trp-P-l-caused toxicity. Hepatocytes were isolated and cultured from rats fed a diet contain-ing a mixture of food additives or a mixture of food colors with half the amount of their re-spective acceptable daily intake for 4 wk. Trp-P-1 was administered to the hepatocytes at various concentrations for 12 h. Synergistic effects of in vivo-dosed food additives and food colors were not observed on Trp-P-l-caused cytotoxicity as estimated by a loss of cell viabil-ity and the reductions of DNA and protein syntheses. On the contrary, we have observed that in vivo administered food colors synergistically facilitated to reduce the activities of glu-coneogenesis and ureogenesis in Trp-P-l-treated hepatocytes. These results suggest that the daily intake of artificial food colors may impair hepatic functions such as gluconeogenesis and ureogenesis, when dietary carcinogens are exposed to the liver cells.

  Center for Academic Publications Japan, Jun. 2000, Journal of Nutritional Science and Vitaminology, 46(3) (3), 130 - 136, English

• Synergistic Anti-Inflammatory Activity of Luteolin and Some Polyphenoles in In Vitro Co-Culture System Composed of Caco-2 and RAW264.7 Cells

  Masashi Mizuno, Takashi Hashimoto

  Nov. 2014, FREE RADICAL BIOLOGY AND MEDICINE, 76, S63 - S63, English

  Summary international conference


• Use of Pulverized Cold-pressed Flaxseed Meal as a Food Ingredient and Antioxidative Potency of Flaxseed Lignans

  Yamashita Takatoshi, Hashimoto Takashi, Kanazawa Kazuki

  Flaxseed has been cultivated for at least 8,000 years in Europe and Asia, mainly for use in industrial paint oil and polymers, and partly for cereals and baked goods. The consumption of flaxseed as a food has recently in-creased dramatically, as it contains a large amount of the n-3 fatty acid, α-linolenic acid, dietary fiber, and flaxseed lignan. We report a new method to improve the processing suitability of flaxseed as a food ingredient. An impact mill with classifier was used to grind cold-pressed flaxseed meal into a fine powder which was stable against oxidation. This finely ground cold-pressed flaxseed meal was suitable for making baked goods such as cookies and bread. Flaxseed lignan in the cold-pressed meal was stable under heat treatment, and the lignan glucoside in flax-seed and its derivatives showed strong antioxidative potency.

  日本調理科学会, 2007, Journal of cookery science of Japan, 40(2) (2), 74 - 81, Japanese

• New Innovations in Chemistry and Biochemistry Vol. 5

  Takashi Hashimoto, Maki Kobayashi, Kazuki Kanazawa

  Joint work, Inhibition of 6-Methylsulfinylhexyl Isothiocyanate for Cell Cycle Progression in Quiescent JB6 Cells Stimulated with Fetal Bovine Serum, Accompanied by Suppression of Cyclin A2 Expression, B P International, Dec. 2021, ISBN: 9789355472038


• 27節 炎症性腸疾患、第6章 効能ごとの機能性、安全性評価法と製品プロモーションに有用な科学的データの示し方、機能性食品表示への科学的なデータの取り方と表示できる許容範囲

  MIZUNO MASASHI, HASHIMOTO TAKASHI

  Joint work, （株）技術情報協会, Apr. 2015, Japanese

  Scholarly book


• RECENT PROGRESS IN MEDICINAL PLANTS : VOL.30 DRUG PLANTS IV [Hardcover] [Jan 01, 2010] SINGH V. K. ET.AL

  Takashi Hashimoto, Tomoe Yamada, Nagai Masashi, Kazuno Yamada, Maki Tanaka, Tomohiro Shimoaki, Jiansheng Long, Kazuki Kanazawa

  Joint work, Wasabi (Wasabia japonica), Studium Press LLC, Jan. 2010, ISBN: 9781933699202


• Functional foods and health

  Naomi Oi, Takashi Hashimoto, Kazuki Kanazawa

  Chapter 10 A possible mechanism that flavonoids exert anti-carcinogenesis with activation of β-glucronidase in cancerous tissues, American Chemical Society, Sep. 2008, English, ISBN: 9780841269828


• がん予防食品開発の新展開－予防医学におけるバイオマーカーの評価システム－ 第2編基盤的研究 第2章がん予防食品因子とデータベースpp.49-61

  大澤 俊彦, 大東 肇, 小林 博, 津金 昌一郎, 金沢 和樹, 橋本 堂史, 豊國 伸哉, 中村 宜督, 傳田 阿由美, 森光 康次郎, その他共著者

  Joint work, (株)シーエムシー出版, 2005, Japanese

  Scholarly book


• Suppression of Cytochrome P4501A Subfamily in Mouse Liver by Oral Intake of Polysaccharides from Mushrooms, Lentinus edodes and Agaricus blazei.(Chapter 21, 235-248), In "Food Factors in Health Promotion andDisease Prevention"

  Hitoshi Ashida, Takashi Hashimoto, Yuji Nonaka, Itsuko Fukuda, Kazuki Kanazawa, Genichi Danno, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno

  Others, American Chemical Society, 2003, English

  Scholarly book


• Suppression of Cytochrome P4501A Subfamily in Mouse Liver by Oral Intake of Polysaccharides from Mushrooms, Lentinus edodes and Agaricus blazei.(Chapter 21, 235-248)

  Hitoshi Ashida, Takashi Hashimoto, Yuji Nonaka, Itsuko Fukuda, Kazuki Kanazawa, Gen-ichi Danno, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno

  Joint work, American Chemical Society, 2003, English

  Scholarly book

• 抗原感作状態でのF-フコイダンのアレルギー抑制効果

  坂口 香奈, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第498回講演会, Feb. 2017, Japanese, 京都大学百周年時計台記念館, Domestic conference

  Oral presentation


• カテキンに惹起される内分泌様培養細胞における細胞内カルシウムシグナル伝達経路の解析

  岸田 佳織, AIHARA YOSHIKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第498回講演会, Feb. 2017, Japanese, 京都大学百周年時計台記念館, Domestic conference

  Oral presentation


• パイナップル由来グルコシルセラミド経口摂取による皮膚機能改善効果とそ作用機序

  西谷 洋輔, 岡 早紀子, 桑田 崇志, HASHIMOTO TAKASHI, 大戸 信明, 桒原 浩誠, MIZUNO MASASHI

  第9回セラミド研究会, Oct. 2016, Japanese, 東京ユビキタス協創広場CANVAS, Domestic conference

  Oral presentation


• アリルイソチオシアネートおよびその代謝物の肝がん細胞に及ぼす影響

  中村 紫乃, HASHIMOTO TAKASHI, 網野 紗与, MIZUNO MASASHI

  第31回日本香辛料研究会, Oct. 2016, Japanese, 長浜勤労者福祉会館, Domestic conference

  Oral presentation


• The elucidation of the mechanism of lentinan-induced inflammatory suppression by visualizimg TNFR1 on the membrane

  SAKAGUCHI KANA, HASHIMOTO TAKASHI, ITO TOSHIKI, SHIRAI YASUHIDE, MIZUNO MASASHI

  Functional and Medical Foods for Chronic Diseases: Bioactive Compounds and Biomarkers, Sep. 2016, English, Harvard Medical School, International conference

  Poster presentation


• OVA誘導アレルギーモデルにおけるF-フコイダンの抗アレルギー効果

  SAKAGUCHI KANA, TANINO YUKA, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本応用糖質科学会平成２８年度大会, Sep. 2016, Japanese, 学校法人福山大学宮地茂記念館, Domestic conference

  Oral presentation


• レンチナンによって誘導されるTNFR1発現変化の可視化による炎症抑制機構の解明

  SAKAGUCHI KANA, HASHIMOTO TAKASHI, ITO TOSHIKI, SHIRAI YASUHITO, MIZUNO MASASHI

  日本食品科学工学会第63回大会, Aug. 2016, Japanese, 名城大学, Domestic conference

  Oral presentation


• マラリア原虫Plasmodium berghei感染ICRマウスにおける硫酸化多糖の抗マラリア効果

  YUTA KASHO, TAKASHI HASHIMOTO, YOSHIKO AIHARA, MIZUNO MASASHI

  日本農芸化学会平成28年度大会, Mar. 2016, Japanese, 札幌, Domestic conference

  Poster presentation


• アリルイソチオシアネート代謝物が肝細胞の脂質蓄積に及ぼす影響に関する研究

  SAYO AMINO, TAKASHI HASHIMOTO, SHINO NAKAMURA, YOSHIKO AIHARA, MIZUNO MASASHI

  日本農芸化学会平成28年度大会, Mar. 2016, Japanese, 札幌, Domestic conference

  Poster presentation


• Oral administration of pineapple glucosylceramide improves skin barrier function by enhancement of collagen production in Hos:HR-1 hairless mice

  SAKIKO OKA, TAKASHI HASHIMOTO, NOBUAKI OHTO, HIROSHIGE KUWAHARA, MIZUNO MASASHI

  Global Conference on Life Science and Biological Engineering, Mar. 2016, English, Kyoto, Serum TGF-β levels of the mice fed the HR-AD diet significantly reduced to about half of the standard diet. However, it recovered to almost the same level as the standard diet in the P-GlcCer group. Collagen contents of skin, which was measured as hydroxyproline, significantly reduced in the mice fed the HR-AD diet compared with the standard diet. On the other hand, P-GlcCer su, International conference

  Poster presentation


• The anti-allergic effects of enterococcus faecalis through toll-like receptor 2

  SAE YAMASHITA, YUKI YOKOYAMA, TAKASHI HASHIMOTO, YOSHIKO AIHARA, MIZUNO MASASHI

  Proceedings of the 19th international conference, Nov. 2015, English, Kobe, International conference

  Poster presentation


• Oral intake of F-fucoidan from Laminaria Japonica prevents type I allergy through secretion of galectin-9

  YUKA TANINO, TAKASHI HASHIMOTO, YOSHIKO AIHARA, TAKAO OJIMA, MIZUNO MASASHI

  Proceedings of the 19th international conference, Nov. 2015, Japanese, Kobe University, International conference

  Poster presentation


• マコンブ由来F-フコイダンによる新規Ⅰ型アレルギー抑制機構

  YUKA TANINO, TAKASHI HASHIMOTO, YOSHIKO AIHARA, TAKAO OJIMA, MIZUNO MASASHI

  日本応用糖質科学会平成２７年度大会, Sep. 2015, Japanese, 奈良, 【目的】これまでに我々はマコンブに含まれるF-フコイダンがⅠ型アレルギー抑制効果を有しており、その効果にガレクチン9が関与していることを明らかにしてきた。ガレクチン9はβガラクトシドを認識するレクチンの一種で、近年IgEと結合することでIgEの肥満細胞への結合を阻害することが報告されている。今回、我々は実際にF-フコイダンによりガレクチン9が血中で増加してⅠ型アレルギー症状を抑制しているのかを検討した。 【方法】F-フコイダン(200 μg/日)を4日間胃内強制投与した。抗原特異的IgEを尾静脈から投与し、30分後に耳介厚を測定、抗原を耳介に塗布した。その2時間後に再び耳介厚を測定し、抗原刺激前後の耳介厚の差を浮腫として表した。F-フコイダンにより誘導されたガレクチン9の関与を調べるため、ガレクチン9のアンタゴニストであるラクトースを抗原特異的IgE, Domestic conference

  Oral presentation


• Anti-inflammatory property of orally administered lentinan through intestinal immunity in ileum in DSS-induced colitis mice

  MIZUNO MASASHI, KEIGO OURA, TAKASHI HASHIMOTO

  The 8th International Medicinal Mushroom Conference, Aug. 2015, English, Manizales, Colombia, Ulcerative colitis (UC) and Crohn’s disease (CD) are pathologically distinct disorders but are commonly refer to as inflammatory bowel disease (IBD). Both conditions show a chronic and relapsed inflammation of the intestine, in which intestinal epithelial cells and macrophages secrete large amounts of chemokines and pro-inflammatory cytokines. Current treatment of IBD relies ma, International conference

  Oral presentation


• Lactobacillus plantarum 22A-3 株はTLR2 を介して小腸粘膜固有層で制御性T 細胞を誘 導し炎症を抑制する

  HAYASHI TAEKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本乳酸菌学会2015年度大会, Jul. 2015, Japanese, 和洋女子大学, Domestic conference

  Oral presentation


• 鉄欠乏マウスにおける味覚嗜好性の変化

  MIYAMOTO TAKESHI, AIHARA YOSHIKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会平成27年度大会, Mar. 2015, Japanese, 岡山大学, Domestic conference

  Oral presentation


• ルテオリンの炎症抑制効果に対するフラボノイド同時摂取の影響

  YAMASHITA SAE, AIHARA YOSHIKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会平成27年度大会, Mar. 2015, Japanese, 岡山大学, Domestic conference

  Oral presentation


• マコンブ由来F-フコイダンのⅠ型アレルギー抑制効果に対するガレクチン9の関与

  TANINO YUKA, MIZUNO MASASHI, HASHIMOTO TAKASHI

  日本農芸化学会平成27年度大会, Mar. 2015, Japanese, 岡山大学, Domestic conference

  Oral presentation


• 237.マコンブ由来F-フコイダンのⅠ型アレルギー抑制効果に対するガレクチン9の関与

  TANINO YUKA, AIHARA YOSHIKO, HASHIMOTO TAKASHI, OJIMA TAKAO, MIZUNO MASASHI

  日本農芸化学会平成27年度大会, Mar. 2015, Japanese, 岡山大学, Domestic conference

  Oral presentation


• 腸管セレトニン産生細胞におけるTRPチャンネルの発現解析

  TAKIZAWA AKIYOSHI, AIHARA YOSHIKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第488回講演会, Jan. 2015, Japanese, 京都大学楽友会館, Domestic conference

  Oral presentation


• 機能性多糖レンチナンは小腸上皮細胞を介して免疫応答を制御する

  OURA KEIGO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第488回講演会, Jan. 2015, Japanese, 京都大学楽友会館, Domestic conference

  Oral presentation


• エピガロカテキンガレートはGLP-1を介して血糖値を調整する

  ODA AKANE, AIHARA YOSHIKO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第488回講演会, Jan. 2015, Japanese, 京都大学楽友会館, Domestic conference

  Oral presentation


• 6-メチルスルフィニルヘキシルイソチオシアネートの細胞周期開始抑制機序に関する研究

  小寺 裕貴, HASHIMOTO TAKASHI, 石村 麻耶, AIHARA YOSHIKO, 金沢 和樹, MIYAKE HIDEYOSHI, YOSHIDA MASARU, MIZUNO MASASHI

  日本農芸化学会 関西支部 支部例会（第487回講演会）, Dec. 2014, Japanese, 神戸大学農学部C101教室（神戸）, Domestic conference

  Oral presentation


• Synergistic anti-inflammatory activity of luteolin and some polyphenols in in vitro co-culture system composed of Caco-2 and RAW264.7 cells

  Masashi Mizuno, HASHIMOTO TAKASHI

  The Society for Free Radical Biology and Medicine’s 21th Annual Meeting (SFRBM 2014), Nov. 2014, Japanese, Sheraton Seattle, Seattle, WA, USA, International conference

  Poster presentation


• SHRSP5/Dmcrラットにおける非アルコール性脂肪性肝疾患に対するクロロゲン酸の抑制効果

  宮崎 泰一, HASHIMOTO TAKASHI, AIHARA YOSHIKO, 北森 一哉, MIZUNO MASASHI

  第19回 日本フードファクター学会学術集会, Nov. 2014, Japanese, 鹿児島大学郡元キャンパス（鹿児島）, Domestic conference

  Oral presentation


• 小腸を介した食品因子の抗アレルギー効果を評価する新規評価法の有用性

  横山 友紀, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本食品免疫学会 第10回学術大会, Oct. 2014, Japanese, 東京大学伊藤国際学術研究センター（東京）, Domestic conference

  Oral presentation


• パイナップル由来グルコシルセラミドが乾燥肌モデルマウスの免疫系に及ぼす影響

  桑田 祟志, 桒原 浩誠, 大戸 信明, HASHIMOTO TAKASHI, MIZUNO MASASHI

  第7回 セラミド研究会学術集会, Oct. 2014, Japanese, 東京ユビキタス協創広場CANVAS（東京）, Domestic conference

  Oral presentation


• Lactobacillus plantarum 22A-3によるTGF-β産生促進と制御性T細胞の誘導効果

  Jarukan Lamubol, HASHIMOTO TAKASHI, 林 多恵子, 西谷 洋輔, MIZUNO MASASHI

  日本食品免疫学会 第10回学術大会, Oct. 2014, Japanese, 東京大学伊藤国際学術研究センター（東京）, Domestic conference

  Oral presentation


• 食品由来多糖類によるナイーブＴ細胞分化の制御

  大浦 圭吾, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本応用糖質科学会 平成26年度大会, Sep. 2014, Japanese, 朱鷺メッセ新潟コンベンションセンター（新潟）, Domestic conference

  Oral presentation


• 抗炎症効果を有するルテオリンの吸収促進物質の探索

  山下 紗枝, HASHIMOTO TAKASHI, AIHARA YOSHIKO, MIZUNO MASASHI

  日本食品科学工学会 第61回大会, Aug. 2014, Japanese, 中村学園大学（福岡）, Domestic conference

  Oral presentation


• マコンブ由来F-フコイダンの抗アレルギー効果

  谷野 有佳, AIHARA YOSHIKO, HASHIMOTO TAKASHI, 尾島 孝男, MIZUNO MASASHI

  日本食品科学工学会 第61回大会, Aug. 2014, Japanese, 中村学園大学（福岡）, Domestic conference

  Oral presentation


• 消化管ホルモンGLP-1を介したAOBの生理効果

  小田 あかね, 宋 苑昤, AIHARA YOSHIKO, 金沢 和樹, HASHIMOTO TAKASHI, MIZUNO MASASHI

  第14回 AOB研究会, Jun. 2014, Japanese, ホテル日航福岡（福岡）, Domestic conference

  Oral presentation


• Lactobacillus plantarum 22A-3の腸管上皮細胞におけるTGF-β1産生誘導効果

  Jarukan Lamubol, HASHIMOTO TAKASHI, 林 多恵子, 西谷 洋輔, MIZUNO MASASHI

  第18回 腸内細菌学会, Jun. 2014, Japanese, 東京大学 伊藤国際学術研究センター（東京）, Domestic conference

  Oral presentation


• ルチン経口投与によるマウス薬物代謝第Ⅱ相酵素に及ぼす影響

  岩見 志歩, HASHIMOTO TAKASHI, AIHARA YOSHIKO, MIZUNO MASASHI

  第68回 日本栄養・食糧学会大会, May 2014, Japanese, 明治大学生田キャンパス（神奈川県川崎市）, Domestic conference

  Oral presentation


• 皮膚機能を改善するパイナップル果実由来グルコシルセラミドによる小腸のIL-23 mRNA発現の亢進

  桑田 崇志, 野嶋 潤, 大戸 信明, 桑原 浩誠, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会2014年度大会, Mar. 2014, Japanese, 明治大学生田キャンパス（神奈川県川崎市）, Domestic conference

  Oral presentation


• 腸管上皮細胞からのTGF-β1産生誘導を伴うLactobacillus plantarum 22A-3 の腸管炎症抑制効果

  ランウボン ジャルカン, HASHIMOTO TAKASHI, 林 多恵子, 西谷 洋輔, MIZUNO MASASHI

  日本農芸化学会2014年度大会, Mar. 2014, Japanese, 明治大学生田キャンパス（神奈川県川崎市）, Domestic conference

  Oral presentation


• タマネギ外皮抽出物のStaphylococcus aureusに対する抗菌効果に関する研究

  黄 達, HASHIMOTO TAKASHI, AIHARA YOSHIKO, 金沢 和樹, MIZUNO MASASHI

  日本農芸化学会2014年度大会, Mar. 2014, Japanese, 明治大学生田キャンパス（神奈川県川崎市）, Domestic conference

  Oral presentation


• 234.機能性多糖レンチナンは小腸上皮細胞を介して免疫応答を制御する

  OURA KEIGO, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会関西支部第488回講演会, Jan. 2014, English, 京都大学楽友会館, Domestic conference

  Oral presentation


• 経口摂取を想定した抗アレルギー効果を有する食品因子探索法の確立

  横山 友紀, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会 関西支部 支部例会（第482回講演会）, Dec. 2013, Japanese, 神戸大学農学部C101教室（神戸）, Domestic conference

  Oral presentation


• フコキサンチノールが誘導するアポトーシスはアクチン重合を伴う

  大原 佳樹, HASHIMOTO TAKASHI, AIHARA YOSHIKO, 金沢 和樹, MIZUNO MASASHI

  日本農芸化学会 関西支部 支部例会（第482回講演会）, Dec. 2013, Japanese, 神戸大学農学部C101教室（神戸）, Domestic conference

  Oral presentation


• Lactobacillus plantarum 22A-3による腸管炎症抑制効果の作用機序の解明

  Jarukan Lamubol, HASHIMOTO TAKASHI, 林 多恵子, 奥田 洋, MIZUNO MASASHI

  日本農芸化学会 関西支部 支部例会（第482回講演会）, Dec. 2013, Japanese, 神戸大学農学部C101教室（神戸）, Domestic conference

  Oral presentation


• レンチナンによる腸炎抑制を引き起こす小腸上皮細胞様受容体について

  雉子谷 百合江, 西谷 洋輔, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本応用糖質科学会 平成25年度大会, Sep. 2013, Japanese, 鹿児島大学（鹿児島）, Domestic conference

  Oral presentation


• Dietary polyphenols induce a secretion of gut hormones from Caco-2 cells

  SONG WON YOUNG, AIHARA YOSHIKO, HASHIMOTO TAKASHI, KANAZAWA KAZUKI

  20th International Congress of Nutrition, Sep. 2013, English, Granada, International conference

  Poster presentation


• A Co-administration of flavonoids to increase their bioavailability in rat

  Ayumi Doi, Yoshiko Aihara, Takuro Momota, Akiyuki Yokoyama, Takashi Hashimoto, Kazuki Kanazawa

  IUNS 20th International Congress of Nutrition, Sep. 2013, English, Granada Congress Centre, Granada, Spain, International conference

  Poster presentation


• 6-Methysulfinyl hexylisothiocyanate inhibits cell cycle progression accompanied by interaction with glyceraldehyde-3-phosphate dehydrogenase

  Maya Ishimura, HASHIMOTO TAKASHI, Maki Tanaka, Yoshiko Aihara, Kazuki Kanazawa

  IUNS 20th International Congress of Nutrition, Sep. 2013, English, Granada Congress Centre, Granada, Spain, International conference

  Poster presentation


• 腸上皮様培養細胞の消化管ホルモン分泌に対するAOBの効果

  SONG Wong Yong, AIHARA Yoshiko, HASHIMOTO Takashi, KANAZAWA Kazuki, MIZUNO Masashi

  第13回 AOB研究会, Jul. 2013, Japanese, 東京, Domestic conference

  Oral presentation


• 食事ポリフェノールによる消化管ホルモンの分泌調節

  SONG Wong Yong, AIHARA Yoshiko, HASHIMOTO Takashi, KANAZAWA Kazuki

  第67回日本栄養・食糧学会大会, May 2013, Japanese, 名古屋, Domestic conference

  Oral presentation


• 食品因子の抗アレルギー効果を評価する新規評価法の有効性

  横山 友紀, HASHIMOTO TAKASHI, MIZUNO MASASHI

  日本農芸化学会2014年度大会, Mar. 2013, Japanese, 明治大学生田キャンパス（神奈川県川崎市）, Domestic conference

  Oral presentation


• 腸管上皮モデルを用いた香辛料成分による消化管ホルモンの分泌の検討

  SONG Wong Yong, AIHARA Yoshiko, HASHIMOTO Takashi, KANAZAWA Kazuki

  第27回日本香辛料研究会, Oct. 2012, Japanese, 藤沢, Domestic conference

  Oral presentation


• マウス黒色腫細胞におけるメラニン産生に対するAOBの抑制効果

  AIHARA Yoshiko, MATSUSHIRO Koharu, HASHIMOTO Takashi, MIZUNO Masashi, KANAZAWA Kazuki

  第12回AOB研究会, Jun. 2012, Japanese, 京都, Domestic conference

  Oral presentation


• ポリフェノール刺激によるヒト腸管由来培養細胞における消化管ホルモンの分泌

  AIHARA Yoshiko, Song Won Young, HASHIMOTO Takashi, KANAZAWA Kazuki

  第66回日本栄養・食糧学会大会, May 2012, Japanese, 仙台, Domestic conference

  Oral presentation


• 脂肪細胞の分化及び脂肪蓄積に対するメチルキサンチン類の影響

  NAKABAYASHI Hidero, HASHIMOTO Takashi, ASHIDA Hitoshi, NISHIUMI Shin, KANAZAWA Kazuki

  日本農芸化学会2009年度大会, 2009, Japanese, Domestic conference

  Oral presentation


• 細胞増殖開始時期における６－メチルスルフィニルヘキシルイソチオシアネートの細胞周期関連タンパク質に及ぼす影響について

  TANAKA Maki, HASHIMOTO Takashi, ASHIDA Hitoshi, MIZUSHINA Yoshiyuki, NAGAI Masashi, OKUNISHI Isao, KANAZAWA Kazuki

  日本農芸化学会2009年度大会, 2009, Japanese, Domestic conference

  Oral presentation


• マウス正常表皮由来JB6細胞の上皮細胞増殖因子による細胞周期開始に及ぼす6－メチルスルフィルヘキシルイソチオシアネートの影響

  TANAKA Maki, HASHIMOTO Takashi, SHIMOAKI Tomohiro, HORI Ryota, ASHIDA Hitoshi, NAGAI Masashi, OKUNISHI Isao, KANAZAWA Kazuki

  第14回日本フードファクター学会, 2009, Japanese, Domestic conference

  Poster presentation


• 6-Methylsulfinyl hexylisotiocyanate inhibits cell cycle progression accompanied by the suppression of cyclin expression in quiescent JB6 cell

  HASHIMOTO Takashi, TANAKA Maki, ASHIDA Hitoshi, NAGAI Masashi, OKUNISHI Isao, KANAZAWA Kazuki

  19th International Congress of Nutrition, 2009, English, International conference

  Oral presentation


• 西洋わさび葉による薬物代謝第二相酵素の誘導について

  岡本 真弓, 橋本 堂史, 永井 雅, 奥西 勲, 金沢 和樹

  第６１回日本栄養･食糧学会大会, May 2007, Japanese, 社団法人 日本栄養･食糧学会, 京都、国立京都国際会館, Domestic conference

  Oral presentation


• 中国茶葉に含まれる抗酸化成分の比較

  呉 白乙拉, 橋本 堂史, 大井 直美, 榊原 啓之, 金沢 和樹

  第10回日本フードファクター学会講演要旨集, Nov. 2005, Japanese, 日本フードファクター学会, 岡山, Domestic conference

  Oral presentation


• わさび葉抽出物が薬物代謝酵素に及ぼす影響について

  藤原 慎司, 橋本 堂史, 後藤 美保, 永井 雅, 奥西 勲, 金沢 和樹

  第10回日本フードファクター学会講演要旨集, Nov. 2005, Japanese, 日本フードファクター学会, 岡山, Domestic conference

  Oral presentation


• ボイセンベリーの生育段階における抗酸化作用の検討

  清田 マキ, 福田 進也, 小泉 典子, 磯田 真由美, 中里 美早紀, 天野 良英, 後藤 美保, 橋本 堂史, 金沢 和樹

  第10回日本フードファクター学会講演要旨集, Nov. 2005, Japanese, 日本フードファクター学会, 岡山, Domestic conference

  Oral presentation


• ボイセンベリーの抗酸化作用の検討

  福田 進也, 橋本 堂史, 後藤 美保, 朴 成源, 清田 マキ, 小泉 典子, 磯田 真由美, 中里 美早紀, 金沢 和樹

  日本過酸化脂質・フリーラジカル学会第29回大会講演要旨集, Oct. 2005, Japanese, 日本過酸化脂質・フリーラジカル学会, 神戸, Domestic conference

  Poster presentation


• Quercetin trans-forms to bioavailable form and prevents hepatpcarcinogenesis

  OI Naomi, HASHIMOTO Takashi, SAKAKIBARA Hiroyuki, KANAZAWA Kazuki

  ISCaP Symposium Abstracts, May 2005, English, 未記入, Kyoto Japan, International conference

  Oral presentation


• Growth inhibition of human hepatoma cells by fucoxanthin is asso-ciated with down-regulation of cyclin D

  DAS Swadesh K, HASHIMOTO Takashi, KOMOTO Akitoshi, KANAZAWA Kazuki

  ISCaP Symposium Abstracts, May 2005, English, 未記入, Kyoto Japan, International conference

  Oral presentation


• 本わさび成分6-(methylsulfinyl)hexyl isothiocy-anate はマウス表皮JB6細胞において細胞周期をG0/G1期で停止する

  伊藤 千夏, 橋本 堂史, 大井 直美, 芦田 均, 村田 充良, 奥西 勲, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• 植物性食品の機能性はポリフェノール含量と相関する

  榊原 啓之, 中川 聡史, 本田 良典, 山口 智子, 藤原 慎司, 山下 貴稔, 佐伯 由利子, 橋本 堂史, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• 近赤外分光法による酸化的ストレスの判定方法の確立

  後藤 美保, ツェンコバ ルミアナ, 橋本 堂史, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• 肝発がんモデルラットにおけるケルセチン代謝について

  大井 直美, 橋本 堂史, 榊原 啓之, 塚原 伸治, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• フラボノール小腸吸収時における新規の代謝経路について

  森 敦美, 羽渕 祥子, 鶴田 宏樹, 橋本 堂史, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• カフェイン構造類似化合物の細胞周期開始阻害活性について

  橋本 堂史, 難波 里衣, 伊藤 千夏, 金沢 和樹

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• Fucoxanthin induces G0/G1 ar-rest in Hep G2 cells through down regulation of Cyclin D1

  DAS Swadesh K, HASHIMOTO Takashi, SHIMIZU Kazuo, KOMOTO Akitoshi, KANAZAWA Kazuki

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, English, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• フラボノール小腸吸収時における新規の代謝経路について

  Atsumi Mori, Shoko Habuchi, Hiroki Tsuruta, Takashi Hashimoto, Kazuki Kanazawa

  日本農芸化学会, 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Poster presentation


• 緑茶抽出物は鉄ニトリロ三酢酸が誘導する酸化的腎障害を抑制する

  後藤 美保, 橋本 堂史, 榊原 啓之, 金沢 和樹

  第９回日本フードファクター学会, 2004, Japanese, 日本フードファクター学会, 淡路夢舞台国際会議場, Domestic conference

  Oral presentation


• 中国茶に含まれる機能性成分の比較

  榊原 啓之, 後藤 美保, 藤原 慎司, 伊藤 千夏, 李 春, Das Swadesh Kumar, 呉白 乙拉, 橋本 堂史, 金沢 和樹

  第９回日本フードファクター学会, 2004, Japanese, 日本フードファクター学会, 淡路夢舞台国際会議場, Domestic conference

  Oral presentation


• 食事成分としてのフラボノイドの体内動態の解析

  上田 裕子, 橋本 堂史, 清水 一雄, 榊原 啓之, 芦田 均, 金沢 和樹

  第９回日本フードファクター学会, 2004, Japanese, 日本フードファクター学会, 淡路夢舞台国際会議場, Domestic conference

  Oral presentation


• ブラジル産プロポリス成分アルテピリンCの大腸がん予防効果

  清水 一雄, Das Swadesh Kumar, 橋本 堂史, 金沢 和樹

  第11回日本がん予防研究会・第27回日本がん疫学研究会, 2004, Japanese, 未記入, 東京, Domestic conference

  Oral presentation


• コーヒー豆の皮で皮膚がん予防

  橋本 堂史

  JBA未来へのバイオ技術・大学技術紹介「本当に効く機能性食品の開発・生産戦略」, 2004, Japanese, 未記入, 未記入, Domestic conference

  Oral presentation


• アルテピリンCの大腸がん予防効果とその作用機構

  清水 一雄, Das Swadesh Kumar, 馬場 正樹, 橋本 堂史, 松浦 幸永, 金沢 和樹

  第９回日本フードファクター学会, 2004, Japanese, 日本フードファクター学会, 淡路夢舞台国際会議場, Domestic conference

  Oral presentation


• Trp-P-1はラット脾細胞に対してキャスパーゼの活性化を伴うアポトーシスとネクローシスを誘導する

  橋本 堂史, 芦田 均, 佐野 貴史, 伊藤 若菜, 金沢 和樹

  2004年度日本農芸化学会本大会, 2004, Japanese, 日本農芸化学会, 広島, Domestic conference

  Oral presentation


• Trp-P-1はラット脾細胞に対してキャスパーゼの活性化を伴うアポトーシスとネクローシスを誘導する

  橋本 堂史, 芦田 均, 佐野 貴士, 伊藤 若菜, 金沢 和樹

  2004年度日本農芸化学会大会, 2004, Japanese, 日本農芸化学会, 広島, Domestic conference

  Oral presentation


• Suppressive effects of catechins on differentiation of 3T3-L1 preadipocytes.

  AOKI Y, HASHIMOTO Takashi, YOSHIDA Kenichi, ASHIDA Hitoshi

  International Conference of O-CHA(tea) Culture and Science., 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Suppressive effects of catechins on differentiation of 3T3-L1 preadipocyte.

  AOKI Y, HASHIMOTO Takashi, YOSHIDA Kenichi, ASHIDA Hitoshi

  2004 International Conference On O-CHA(tea) Culture And Science, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Protective effects of Chinese tea on carbon tetrachloride-induced liver injury.

  GOTO Miho, HASHIMOTO Takashi, FUKUDA S, NOBUCHI M, PIAO C, SHANG W, NAMBA R, LU Y, KANAZAWA Kazuki

  2004 International Conference On O-CHA(tea) Culture And Science, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Protective effect of green tea on etoposide-induced apoptosis in rat tymocytes.

  HASHIMOTO Takashi, KANAZAWA Kazuki, ASHIDA Hitoshi

  International Conference of O-CHA(tea) Culture and Science., 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Protective effect of green tea on etoposide-induced apoptosis in rat thymocytes.

  HASHIMOTO Takashi, KANAZAWA Kazuki, ASHIDA Hitoshi

  2004 International Conference On O-CHA(tea) Culture And Science, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Fucoxanthin inhibits proliferation accompanied with cell cycle arrest on HepG2 cells.

  DAS Swadesh Kumar, HASHIMOTO Takashi, SHIMIZU Kazuo, KOMOTO A, KANAZAWA Kazuki

  Worldnutra 2004, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Fucoxanthin caused cell cycle arrest at G0/G1 phase in human colom carcinoma WiDr cells.

  Das Swadesh Kumar, SHIMIZU Kazuo, HASHIMOTO Takashi, KANAZAWA Kazuki

  第11回日本がん予防研究会・第27回日本がん疫学研究会, 2004, English, 未記入, 東京, Domestic conference

  Oral presentation


• DNA酸化的損傷について

  藤原 慎司, 上原 摩耶, 橋本 堂史, 榊原 啓之, 金沢 和樹

  日本過酸化脂質・フリーラジカル学会第28回大会, 2004, Japanese, 日本過酸化脂質・フリーラジカル学会, 名古屋大学, Domestic conference

  Oral presentation


• 6-Methylsulfinylhexyl isothiocyanate inhibits cell cycle progression in mouse epidermal JB6 cells.

  HASHIMOTO Takashi, OI Naomi, ASHIDA Hitoshi, OKUNISHI I, MURATA M, KANAZAWA Kazuki

  Symposium on Dietary Factors & Cancer Prevention, Proceedings, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• 6-Methylsulfinylhexyl isothiocyanate inhibits cell cycle progression in mouse epidermal JB6 cells.

  HASHIMOTO Takashi, OI Naomi, ASHIDA Hitoshi, OKUNISHI I, MURATA M, KANAZAWA Kazuki

  Dietary Factors and Cancer Prevention., 2004, Japanese, 未記入, 未記入, International conference

  Oral presentation


• 食品に含まれるポリフェノールの機能解析

  橋本 堂史

  ㈱日本食品開発研究所第十四回年次講演会, 2003, Japanese, ㈱日本食品開発研究所, 未記入, Domestic conference

  Oral presentation


• Caffeine induces G0/G1 cell arrest by targeting CDK4-Rb phosphorylation

  HASHIMOTO Takashi, HE Z, SCHMID P C, MA W.-Y, CHO Y.-Y, BODE A M, DONG Z

  Proceedings of the American Association for Cancer Research, 2003, English, 未記入, 未記入, International conference

  Oral presentation

• 日本香辛料研究会


• 日本過酸化脂質・フリーラジカル学会


• 日本栄養・食糧学会


• 日本フードファクター学会


• American Association for Cancer Research


• 日本農芸化学会

• 乳酸発酵処理が引き起こす豆乳中の成分変化が脂質代謝改善作用に及ぼす影響

  小林 麻貴, 橋本 堂史

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸学院大学, 01 Apr. 2018 - 31 Mar. 2023

  オルニチンの生体調節機能について、以下の項目について研究を実施した。 （１）肝細胞の脂質蓄積に及ぼすオルニチンの効果：これまで明らかにしてきたヒト肝細胞株HepG2細胞におけるオルニチンの脂肪蓄積抑制効果に関する詳細な機序をAMPKシグナルの下流シグナルとしてオートファジーの促進に着目し、オートファジーの阻害剤であるクロロキンを用いて検討したが、脂肪蓄積抑制効果に影響を及ぼすことはなかった。 （２）肝細胞におけるアンモニア誘導性細胞死に及ぼすオルニチンの保護効果：マウス肝細胞株Hepa1c1c7細胞にオルニチンを作用させると、アンモニア誘導性の細胞死を抑制すると共に、培養液中の尿素含量が上昇する。今年度は、このアンモニアを尿素に解毒することで細胞死を抑制していると考え、オルニチン処理時の尿素回路の亢進について検討した。オルニチンを作用させたHepa1c1c7細胞では細胞中のオルニチン濃度が上昇すると共に、オルニチンの前駆物質アルギニン濃度も増加していたことから、尿素回路が亢進していることが明らかになった。また、ヒト肝細胞株HepG2細胞においてもオルニチン処理により同様のイベントが確認できた。つまり、オルニチンの肝細胞保護機能の機序のひとつとして、尿素回路を亢進することで毒性を示すアンモニア解毒していると考えた。 （３）オルニチン経口摂取時における体内動態：ICRマウス（オス、6週齢）に胃ゾンデを用いて375 mg/Lのオルニチン水溶液200 μLを単回で経口投与し、経時的に血中および肝臓中にオルニチン濃度を調べた。血中、肝臓中のいずれにおいても経時的にその濃度は上昇し、血中では45分後、肝臓中では1時間後に最大濃度に達した。一方、自由摂取ではオルニチンの蓄積は見られなかった。


• ガレクチン９分泌誘導を有した食品因子による新規アレルギー抑制

  水野 雅史

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2017

  Competitive research funding


• ケンフェロール分解物による薬物代謝第Ⅱ相酵素活性化機序の解明

  橋本 堂史

  科学研究費補助金／基盤研究(C), Apr. 2012 - Mar. 2015, Principal investigator

  Competitive research funding


• カフェインによる抗がん作用機構の解明

  橋本 堂史

  科学研究費補助金／若手研究(B), 2005, Principal investigator

  Competitive research funding