Research activity information

• 1999 日本弱視斜視学会, 廣石賞, Differential expression of immediate-early genes, c-fos and zif268, in the visual cortex of young rats: effects of a noradrenergic neurotoxin on their expression. Yamada Y, Hada Y, Imamura K, Mataga N, Watanabe Y, Yamamoto M. Neuroscience. 1999;92

  Yamada Yuko

  Japan society

• Three-year outcomes of surgical bleb revision with mitomycin C for early scarring bleb after trabeculectomy.

  Risa Caraher-Masuda, Mari Sakamoto, Mina Okuda, Fumio Takano, Sotaro Mori, Kaori Ueda, Akiyasu Kanamori, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: To report the 3-year outcomes of surgical bleb revision (SBR) with mitomycin C (MMC) for early scarring bleb after trabeculectomy (TLE). STUDY DESIGN: Retrospective observational study. METHODS: We included glaucoma patients aged ≧ 18 who underwent SBR with MMC within 6 months of their first TLE at Kobe University Hospital and were followed for at least 6 months. The primary outcome measure was the three-year success rate of SBR. We defined surgical success as: intraocular pressure (IOP) reduction ≧ 20% from baseline and 5 ≦ IOP ≦ 18 mmHg. Failure was defined when the IOP deviated from the criteria, when the eye required additional glaucoma surgery, and when the eye lost light perception. Complete success (CS) was success without glaucoma medications and qualified success (QS) was success with glaucoma medications. The secondary outcome measures included IOP, the number of glaucoma medications, mean deviation (MD), best corrected visual acuity (BCVA), corneal endothelial cell density (ECD), and surgical complications. RESULTS: Sixty-eight eyes of 68 patients were analyzed. The median interval between initial TLE and SBR was 2 months. Overall success rate at three-year after SBR were 45.1% and 9.6% for QS and CS, respectively. A greater number of medications used before TLE was a contributing factor to failure (P = 0.02). 22 eyes (32.4%) underwent additional glaucoma surgery, and 41 eyes (60.3%) were spared from additional glaucoma surgery within 3 years after SBR. The median IOP decreased form 24.0 mmHg to 11.0 mmHg 3 years after SBR, and the number of medications decreased from 4 to 2 (P < 0.01). MD remained unchanged, but BCVA and ECD decreased at 3years postoperatively. There were no serious complications of SBR. CONCLUSION: SBR may be an effective treatment option for early scarring blebs after TLE but is unsuccessful in eyes that have used many glaucoma medications prior to TLE.

  Nov. 2024, Japanese journal of ophthalmology, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• One-year results of trabeculectomy with emphasis on the effect of patients' age.

  Yuto Iwaki, Sotaro Mori, Mina Okuda-Arai, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: This study investigated the association between one-year surgical outcomes following trabeculectomy and age, accounting for confounding factors. STUDY DESIGN: Retrospective observational study. METHOD: Analyzing data from 305 patients undergoing initial trabeculectomy from 2019 onward, we employed three approaches to adjust variables: stratified analysis, regression analysis, and propensity score matching. Surgical success at 1-year post-surgery was defined by two criteria: achieving intraocular pressure of between 5 and 15 mmHg with a ≥ 20% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion A); achieving intraocular pressure of between 5 and 12 mmHg with a ≥ 30% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion B). RESULTS: Stratified analysis by age unveiled a significant increase in exfoliation glaucoma (XFG) and a trend towards shorter axial lengths with advancing age (both p < 0.0001). Older age groups were more likely to experience surgical failure in both Criterion A and B (p = 0.21, < 0.01). Univariate analysis showed age as a significant factor in surgical failure for Criterion A (p < 0.05) and a nearly significant factor for Criterion B (p = 0.12). However, this trend was not evident in multivariate analysis (p = 0.23/0.88), where XFG became a significant factor for surgical failure (both p < 0.001) in Criteria A and B. Propensity score matching revealed no significant differences in surgical success rates for Criteria A and B between younger and older patients (p = 1.00 and 0.88). CONCLUSION: Age is not a primary determinant of failure in trabeculectomy; however, the increasing incidence of XFG with aging suggests a potential for poorer outcomes.

  Oct. 2024, Japanese journal of ophthalmology, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高濃度フィブリノーゲンによるICAM-1経路を介した網膜組織傷害の検討

  曽谷 育之, 今井 尚徳, 山田 裕子, 北村 萌, 盛 崇太朗, 松宮 亘, 三木 明子, 楠原 仙太郎, 中村 誠

  (公財)日本眼科学会, Mar. 2024, 日本眼科学会雑誌, 128(臨増) (臨増), 174 - 174, Japanese


• Potentially compromised systemic and local lactate metabolic balance in glaucoma, which could increase retinal glucose and glutamate concentrations.

  Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  To investigate the association between lactate metabolism and glaucoma, we conducted a multi-institutional cross-sectional clinical study and a retinal metabolomic analysis of mice with elevated intraocular pressure (IOP) induced by intracameral microbead injection. We compared lactate concentrations in serum and aqueous humor in age-matched 64 patients each with primary open-angle glaucoma (POAG) and cataract. Neither serum nor aqueous humor lactate concentrations differed between the two groups. Multiple regression analysis revealed that only body mass index showed a significant positive correlation with serum and aqueous humor lactate concentration in POAG patients (rs = 0.376, P = 0.002, and rs = 0.333, P = 0.007, respectively), but not in cataract patients. L-Lactic acid was one of the most abundantly detected metabolites in mouse retinas with gas chromatography and mass spectrometry, but there were no significant differences among control, 2-week, and 4-week IOP elevation groups. After 4 weeks of elevated IOP, D-glucose and L-glutamic acid ranked as the top two for a change in raised concentration, roughly sevenfold and threefold, respectively (ANOVA, P = 0.004; Tukey-Kramer, P < 0.05). Glaucoma may disrupt the systemic and intraocular lactate metabolic homeostasis, with a compensatory rise in glucose and glutamate in the retina.

  Feb. 2024, Scientific reports, 14(1) (1), 3683 - 3683, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of glaucoma medications on subsequent Schlemm's canal surgery outcome: Cox proportional hazard model and propensity score-matched analysis.

  Mina Okuda-Arai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: The impact of various preoperative glaucoma medications on Schlemm's canal surgery outcomes remains unclear. This study aimed to investigate the impact of preoperative glaucoma medications on the postoperative 1-year outcomes of μTLO. METHODS: We analyzed the medical records of 218 patients who underwent their first μTLO to investigate the 1-year postoperative outcomes. Cox proportional hazard regression analysis was performed with surgical failure as the dependent variable and each type of preoperative medication as the independent variable. We also compared the 1-year outcomes of μTLO between users and non-users of specific medications using propensity score matching. Surgical success was defined as a postoperative intraocular pressure ranging from 5 to 21 mmHg, a ≥20% reduction in IOP from baseline, and no additional glaucoma surgery within 1 year postoperatively. RESULTS: The Cox proportional hazard analysis showed that all drugs that do not increase the conventional outflow exhibited hazard ratios greater than 1.0, and the preoperative use of β-blockers and oral CAI was a significant surgical risk factor (hazard ratio: 2.65 and 2.45, p = 0.04 and <0.001). In the propensity score matching analysis, success rates at 1 year postoperatively were 55/85, 54/79, 60/73, and 40/76% for users/non-users of β-blockers, topical CAIs, an alpha-2 adrenergic agonist, and an oral CAI, respectively. Kaplan-Meier survival curves in these comparisons also demonstrated that preoperative β-blockers and oral CAI use were significant surgical risks (p = 0.01, <0.001). CONCLUSION: Our study suggests that preoperative medications that do not involve conventional pathway outflow have a detrimental effect on subsequent Schlemm's canal surgery outcomes.

  Sep. 2023, Acta ophthalmologica, English, International magazine

  Scientific journal


• 線維柱帯切開術(眼内法)術後早期に施行された線維柱帯切除術の術後1年成績

  岡 隼生, 坂本 麻里, 荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 160 - 160, Japanese


• 線維柱帯切開術(眼内法)術後早期に施行された線維柱帯切除術の術後1年成績

  岡 隼生, 坂本 麻里, 荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 160 - 160, Japanese


• 原発開放隅角緑内障と血清・前房水乳酸濃度の関連についての検討

  荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 金森 章泰, 前田 秀高, 三木 貴子, 内藤 知子, 尾上 弘光, 廣岡 一行, 河野 通大, 杉原 一暢, 谷戸 正樹, 中村 誠

  日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 197 - 197, Japanese


• Favorable effect of ripasudil use on surgical outcomes of microhook ab interno trabeculotomy.

  Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: We have previously demonstrated that prolonged use of glaucoma medications was associated with a poor surgical outcome of ab interno trabeculotomy (µTLO). Given that almost all types of glaucoma eye drop either enhance the drainage through the uveoscleral pathway or reduce aqueous humor production, we hypothesized that prolonged use of these medications might cause disuse atrophy of the conventional pathway. In contrast, ripasudil increases the conventional outflow and eventually shows a favorable outcome of µTLO. This study aimed to evaluate the effect of ripasudil use on µTLO outcomes. METHOD: The medical charts of 218 patients who underwent µTLO were analyzed retrospectively. We compared the 1-year outcome between ripasudil users versus nonusers by using propensity score matching. We set the covariates as age, sex, glaucoma types, preoperative intraocular pressure (IOP), the mean deviation values of visual field tests, the presence or absence of concomitant cataract surgery, trabecular meshwork incision range, the presence or absence of any glaucoma medication except ripasudil and duration of glaucoma medical therapy. Success was defined as a postoperative IOP between 5 and 21 mmHg, a ≥ 20% IOP reduction from baseline, and no additional glaucoma surgery at postoperative 1 year. RESULT: Fifty-seven patients each were allocated to the ripasudil users or nonusers. The 1-year success rates were 74% in ripasudil users and 51% in nonusers (p = 0.01). Kaplan‒Meier survival curves also showed that the ripasudil users had a higher survival distribution (p = 0.01). CONCLUSION: The patients who took ripasudil showed a favorable 1-year outcome of µTLO.

  Sep. 2023, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 261(9) (9), 2603 - 2610, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Test-retest repeatability of the imo binocular random single-eye test and Humphrey monocular test in patients with glaucoma.

  Hideaki Toyokuni, Mari Sakamoto, Kaori Ueda, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: To evaluate the reproducibility of the imo binocular random single-eye test (BRSET) and Humphrey Field Analyzer (HFA) monocular test in patients with glaucoma. STUDY DESIGN: Retrospective observational study. METHODS: We measured the visual fields (VF) of patients with glaucoma using the BRSET and HFA. All tests were repeated two months later. Mean sensitivity (MS), mean deviation (MD), sensitivity at each test location, and reliability indices were compared between the test days. Wilcoxon signed-rank test, interclass correlation coefficient (ICC), correlation coefficients, and Bland-Altman plots were generated for analysis. RESULTS: We analyzed the VFs of 46 patients with glaucoma. There were no test-retest differences for MS and MD, and ICCs were > 0.9 for MS and MD in both perimeters. Inter-test correlations for MS and MD were high. The limits of agreement (LoAs) (lower, upper limit) between test days for MS were (- 3.4, 4.0) for BRSET and (-3.3, 3.0) for HFA. The LoA for MD was (- 3.3, 3.8) for BRSET and (- 3.2, 2.9) for HFA. Sensitivity at each testing location was more variable between testing days for BRSET than for HFA. For reliability indices, LoAs between testing days were wider for BRSET than for HFA. CONCLUSION: The imo BRSET showed similar reproducibility to HFA in MS and MD. However, sensitivity at each test location varied more for BRSET than for HFA. Further studies are needed to verify the reproducibility of the imo BRSET.

  Sep. 2023, Japanese journal of ophthalmology, 67(5) (5), 578 - 589, English, Domestic magazine

  Scientific journal


• Detection of Relative Afferent Pupillary Defect and Its Correlation with Structural and Functional Asymmetry in Patients with Glaucoma Using Hitomiru, a Novel Hand-Held Pupillometer.

  Makoto Nakamura, Mari Sakamoto, Kaori Ueda, Mina Okuda, Fumio Takano, Yuko Yamada-Nakanishi

  Patients with asymmetric glaucomatous optic neuropathy (GON) present a relative afferent pupillary defect (RAPD) in the eye with more advanced damage. Although useful, pupillometric RAPD quantification is not widely used as it is not portable. Whether asymmetry of the peripapillary capillary perfusion density (CPD) detected using optical coherence tomography angiography correlates with the severity of RAPD remains unknown. This study assessed RAPD in 81 patients with GON using Hitomiru, a novel hand-held infrared binocular pupillometer. The correlation and ability to detect clinical RAPD based on the swinging flash light test of two independent RAPD parameters (the maximum pupil constriction ratio and the constriction maintenance capacity ratio) were assessed. The coefficient of determination (R2) was calculated between each of the two RAPD parameters and asymmetry of the circumpapillary retinal nerve fiber layer thickness (cpRNFLT), ganglion cell layer/inner plexiform layer thickness (GCL/IPLT), and CPD. The two RAPD parameters showed a correlation coefficient of 0.86 and areas under the receiver operating characteristic (ROC) curve of 0.85-0.88, with R2 being 0.63-0.67 for the visual field, 0.35-0.45 for cpRNFLT, 0.45-0.49 for GCL/IPLT, and 0.53-0.59 for CPD asymmetry. Hitomiru has high discriminatory performance in detecting RAPD in patients with asymmetric GON. CPD asymmetry may better correlate with RAPD than cpRNFLT and GCL/IPLT asymmetry.

  Jun. 2023, Journal of clinical medicine, 12(12) (12), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• マイクロフックトラベクロトミー(μTLO)の1年後成績への術前緑内障点眼の影響

  昭原 郁仁, 盛 崇太朗, 奥田 実奈, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 218 - 218, Japanese


• Heads-Up Surgeryにおける無彩色映像下での内境界膜の視認性

  岩根 友佳子, 今井 尚徳, 木村 朱里, 曽谷 育之, 山田 裕子, 三木 明子, 中村 誠

  (公社)日本眼科手術学会, Dec. 2022, 眼科手術, 36(臨増) (臨増), 172 - 172, Japanese


• Risk of surgical failure and hemorrhagic complications associated with antithrombotic medication in glaucoma surgery.

  Fumio Takano, Sotaro Mori, Mina Okuda, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: The purpose of this retrospective study was to determine the extent to which the use of antithrombotic drugs during glaucoma surgery contributes to surgical failure and postsurgical hemorrhagic complications. METHODS: Glaucoma surgeries were categorized into three groups: trabeculotomy (TLO), trabeculectomy (TLE), and long-Tube shunt surgery (Tube). At 1 year after surgery, the following criteria for surgical success were met: intraocular pressure (IOP) in the 5-21-mmHg range, IOP reduction of at least 20% from the preoperative level, and no additional glaucoma surgeries. We compared the percentages of the success rates and hemorrhagic complications between antithrombotic medication experiencers and non-experiencers. Furthermore, we adjusted the preoperative factors between the two groups using a propensity score analysis in TLO and TLE surgeries. RESULTS: A total of 910 glaucoma surgeries were included, with TLO, TLE, and Tube accounting for 353, 444, and 113 surgeries, respectively. Preoperative antithrombotic medications were administered to 149 patients in all glaucoma surgeries: 37 patients used only anticoagulants, 102 used only antiplatelets, and 10 used both. There was no significant difference in the success rates of any of the procedures. The hemorrhagic complications (hyphema and vitreous hemorrhage rate) were significantly higher in the patients who underwent TLE and Tube. The surgical success rates of TLO and TLE were not significantly different after the two groups were matched by propensity score. CONCLUSION: The perioperative use of antithrombotic drugs did not affect success for any of the procedures. However, it increased early postoperative hemorrhagic complications for TLE and Tube.

  Nov. 2022, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 260(11) (11), 3607 - 3615, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• m.14487T>C変異を認めたLHON plusの一例

  岡山 真由佳, 上田 香織, 千原 典夫, 昭原 郁仁, 奥田 実奈, 高野 史生, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本神経眼科学会, Oct. 2022, 神経眼科, 39(増補1) (増補1), 92 - 92, Japanese


• 線維柱帯切除術後の早期濾過胞機能不全に対するマイトマイシンC併用濾過胞再建術の術後3年成績

  増田 理沙, 坂本 麻里, 昭原 郁仁, 奥田 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 栗本 拓治, 金森 章泰, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 101 - 101, Japanese


• 当院で経験した虹彩分離症5症例の臨床的特徴

  昭原 郁仁, 上田 香織, 奥田 実奈, 高野 史生, 盛 崇太朗, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 146 - 146, Japanese


• マイクロフックトラベクロトミー(μTLO)の術成績に対する術前リパスジル点眼投与の影響

  奥田 実奈, 盛 崇太朗, 昭原 郁仁, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 154 - 154, Japanese


• Association of the prolonged use of anti-glaucoma medications with the surgical failure of ab interno microhook trabeculotomy.

  Mina Okuda, Sotaro Mori, Fumio Takano, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: This study examined the perioperative factors affecting surgical success in ab interno microhook trabeculotomy (μTLO). METHODS: A total of 146 consecutive patients who underwent μTLO were included in this retrospective study. We performed Cox proportional hazard modelling by setting surgical success at 1 year as an objective variable. The explanatory variables included age, sex, glaucoma type, preoperative intraocular pressure (IOP), glaucoma drug score, mean deviation (MD) of the Humphrey visual field test, duration of glaucoma drug use, antithrombotic drug use, combined cataract surgery, incision range and diabetes mellitus. Additionally, we performed 1:1 matching using propensity score analysis and compared the perioperative parameters between durations of glaucoma drug use of <4.5 years and ≥ 4.5 years (50 patients each). We defined surgical success as satisfaction of all three criteria: IOP 5-21 mmHg, IOP reduction of ≥20% from the preoperative IOP and no additional glaucoma surgery. RESULTS: The Cox proportional hazard model revealed that a longer duration of anti-glaucoma medication was significantly associated with surgical failure. Propensity score matching analysis showed that the <4.5-year users of anti-glaucoma drugs had significantly higher success rates than the ≥4.5-year users (72% versus 52%; p = 0.04). CONCLUSIONS: The prolonged use of multiple glaucoma drugs adversely affected the outcome of μTLO at least at 1 year postoperatively.

  Sep. 2022, Acta ophthalmologica, 100(6) (6), e1209-e1215, English, International magazine

  Scientific journal


• ラニビズマブの硝子体内注射による未熟児網膜症の治療効果

  高野 史生, 上田 香織, 三木 明子, 今井 尚徳, 中西 裕子, 中村 誠

  眼科臨床紀要会, Jun. 2022, 眼科臨床紀要, 15(6) (6), 418 - 418, Japanese


• 緑内障患者におけるアイモ両眼ランダム測定の再現性の検討

  豊国 秀昭, 坂本 麻里, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 172 - 172, Japanese


• Comparison of efficacy and early surgery-related complications between one-quadrant and two-quadrant microhook ab interno trabeculotomy: a propensity score matched study.

  Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: We compared the 1-year outcomes and early surgery-related complications between 1-quadrant and 2-quadrant microhook ab interno trabeculotomy (TLO). METHODS: Medical chart extraction was performed on 47 consecutive patients with 1-quadrant incision and 37 consecutive patients with 2-quadrant incision of trabecular meshwork. Logistic regression analysis was conducted to calculate the propensity score to create a 1:1 match for a comparative analysis of 1-year postoperative success. Success was defined as postoperative intraocular pressure (IOP) between 5-21 mmHg, >20% IOP reduction from baseline, and no additional glaucoma surgery. Outcome-related covariates were age, glaucoma type, mean deviation of visual field tests, preoperative IOP, the number of preoperative glaucoma eye drops and the presence of combined cataract surgery. Thirty eyes from each group were compared. RESULTS: The median preoperative IOP was not different between the 1-quadrant and 2-quadrant groups (28.5 mmHg, quartile range 23-33.5 versus 27 mmHg, 23.3-30.0, p = 0.47). There was no difference in median postoperative IOP at 1 year (15 mmHg versus 16 mmHg, p = 0.80). The success rate was 73% in the 1-quadrant group versus 70% in the 2-quadrant group (p = 1.00). The 2-quadrant group had a significantly higher proportion of patients with transiently elevated IOP (47%) than the 1-quadrant (17%; Fisher's exact test, p = 0.02). There was no difference of hyphema formation (Fisher's exact test, p = 0.18). CONCLUSION: The 1-year success rate was not significantly different between 1- and 2-quadrant incisions of microhook TLO. However, the 2-quadrant TLO showed significantly higher proportion of post-surgical transient IOP elevation.

  Dec. 2021, Acta ophthalmologica, 99(8) (8), 898 - 903, English, International magazine

  Scientific journal


• Three-year outcome of sulcus fixation of Baerveldt glaucoma implant surgery.

  Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: The purpose of this study was to evaluate the 3-year surgical outcome of the sulcus fixation of Baerveldt glaucoma implant (BGI), focusing on corneal damage. METHODS: This prospective observational study included 37 patients who underwent a median of two previous glaucoma surgeries and sulcus fixation of BGI for the first time. Each patient's intraocular pressure (IOP), glaucoma drug score, corneal endothelial cell density (ECD), and logMAR-converted best-corrected visual acuity (VA) were measured preoperatively and postoperatively until 36 months after surgery. Complete success was defined as reduced IOP (5-21 mmHg and >20% rate), without corneal damage (postoperative development of decompensation, unmeasurable ECD, or reduction in ECD of >20%), without loss of light perception, and without additional surgery requirement. Qualified success was defined by excluding the corneal criteria from complete success. RESULTS: A total of 51% (19/37) patients experienced complete treatment success, whereas 86% (32/37) had qualified success. The median IOP (glaucoma drug score) decreased from 26 mmHg (5) to 15 mmHg (2) at three years postoperatively. The median postoperative ECD (reduction rate) decreased from 1838 cells/cm2 preoperatively to 1587 cells/mm2 (14%) at one year, 1358 cells/mm2 (26%) at two years, and 1228 cells/mm2 (33%) at three years postoperatively. One month after surgery, the VA was significantly reduced from preoperative values but did not decline after that. CONCLUSION: Sulcus fixation of BGI was effective for IOP reduction. However, ECD decreased over time.

  Dec. 2021, Acta ophthalmologica, 99(8) (8), e1435-e1441, English, International magazine

  Scientific journal


• The beneficial impact of filtration surgery on antiviral therapy cessation in patients with cytomegalovirus-related secondary glaucoma.

  Yusuke Murai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

  PURPOSE: Cytomegalovirus (CMV)-related keratouveitis elevates intraocular pressure (IOP). Antiviral therapy does not always control IOP and some patients do not tolerate systemic antiviral therapy because of the side effects. The purpose of this study is to evaluate the clinical characteristics of patients with CMV-related keratouveitis and determine the impact of glaucoma surgeries on the postoperative antiviral therapy regimen. METHODS: We enrolled twenty-two patients with CMV-DNA-positive keratouveitis between June 2012 and July 2019 in Kobe University Hospital. The following clinical parameters were collected: gender, age, history of previous intraocular surgery, antiviral medications, visual acuity, IOP, glaucoma drug score, corneal endothelial cells density, and the mean deviation of a Humphrey visual field test at the first visit and before and 1 year after glaucoma surgery. RESULTS: All twenty-two patients started on oral and/or topical antiviral therapy. Eighteen patients needed glaucoma surgery despite their antiviral medications. Nine patients underwent trabeculotomy (TLO) and nine underwent trabeculectomy (TLE) as the first surgical intervention. Six of patients who initially underwent TLO and two of the patients who initially underwent TLE required additional TLE within 1 year. Each of the 15 patients who underwent at least 1 TLE showed a reduction in the magnitude and variation of IOP and glaucoma drug scores and 13 patients were able to discontinue antiviral therapy. For the remaining 4 patients, IOP and inflammation were controlled but with antiviral medications. CONCLUSIONS: In patients with CMV-related keratouveitis, TLE decreases and stabilizes IOP and contributes to withdrawal from antiviral medications.

  Nov. 2021, BMC ophthalmology, 21(1) (1), 389 - 389, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当院におけるMOG抗体陽性視神経炎自験例の臨床経過の検討

  昭原 郁仁, 上田 香織, 栗本 拓治, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2021, 神経眼科, 38(増補1) (増補1), 72 - 72, Japanese


• 水平経線を保つ視野欠損を呈する視神経炎患者と虚血性視神経症の病変の局在と視野異常との関連

  越智 博隆, 栗本 拓治, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2021, 神経眼科, 38(増補1) (増補1), 87 - 87, Japanese


• 黄斑部毛細血管拡張に伴う嚢胞様黄斑浮腫に嚢胞様腔内壁切開術が奏効した1例

  牧 仁美, 今井 尚徳, 山田 裕子, 鉄本 章, 林田 真由香, 大塚 慶子, 三木 明子, 中村 誠

  眼科臨床紀要会, Nov. 2021, 眼科臨床紀要, 14(11) (11), 757 - 757, Japanese


• Protocol to test the efficacy and safety of frequent applications of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomised prospective study.

  Kaori Ueda, Takuji Kurimoto, Fumio Takano, Yusuke Murai, Sotaro Mori, Mari Sakamoto, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

  INTRODUCTION: Leber hereditary optic neuropathy (LHON) is an acute or subacute inherited optic neuropathy caused by mitochondrial mutations. More than 90% of patients with LHON have one of three point mutations (ie, G3460A, G11778A and T14484C). We previously reported that a 12-week session of skin electrical stimulation (SES) with a 2-week interval significantly improved visual acuity and field tests 1 week after the last stimulation and without adverse effects in 10 cases of LHON carrying the mt DNA G11778A mutation. In the present study, we will examine the magnitude and persistence of the efficacy and presence or absence of adverse events using SES with a more frequent stimulation protocol. METHODS AND ANALYSIS: This study will be a single-arm, open-labelled, non-randomised clinical study that analyses 15 cases of LHON with G11778A mutation. All participants will take a portable SES device home and perform SES by themselves every other day for 12 weeks. The logarithm for the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) at 1 week after the last SES will be measured as the primary outcome. LogMAR BCVA will be measured at four and 8 weeks after the last SES treatment. The Humphrey visual field sensitivity test using size V stimulation and critical fusion frequency at 1, 4 and 8 weeks after the last SES session will be secondary outcome measurements. Slit-lamp examination, optical coherence tomography and specular microscopy will also be performed to verify the safety of SES. ETHICS AND DISSEMINATION: The protocol was approved by the Institutional Review Board at Kobe University, Japan (Approval No.C190030). This study is in progress and deserves Pre-result. All documents communicating with the ethics committee will be reposited by the researcher. Modifications to the protocol will be reviewed by the ethics committee and implemented after approval. Data monitoring will be performed by a researcher who is not involved in the study every 6 months after approval. The research summary results will be registered in the Japan Registry of Clinical Trials (jRCTs) and made available to participants in accordance with the terms described in the documents. In addition, the results of this study will be presented at domestic and international meetings and published in peer-reviewed journals within a year after data is fixed. TRIAL REGISTRATION NUMBER: jRCTs052200033.

  Oct. 2021, BMJ open, 11(10) (10), e048814, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 裂孔原性網膜剥離に対する硝子体手術後の歪視量に寄与する周術期因子の検討

  山田 裕子, 今井 尚徳, 鉄本 章, 林田 真由香, 大塚 慶子, 三木 明子, 中村 誠

  眼科臨床紀要会, Oct. 2021, 眼科臨床紀要, 14(10) (10), 684 - 685, Japanese


• ロングチューブシャント術後の被膜除去術の短期成績

  奥田 実奈, 盛 崇太朗, 高野 史生, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2021, 日本緑内障学会抄録集, 32回, 136 - 136, Japanese


• 緑内障診療におけるアイモ両眼ランダム測定の有用性の検討

  林 由紀子, 坂本 麻里, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, May 2021, 日本眼科学会雑誌, 125(5) (5), 530 - 538, Japanese


• マイクロフックトラベクロトミーの緑内障点眼歴による術後成績の比較

  奥田 実奈, 盛 崇太郎, 高野 史生, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2021, 日本眼科学会雑誌, 125(臨増) (臨増), 237 - 237, Japanese


• 傾向スコア解析による血栓予防薬の有無に対する緑内障手術の術成功と出血合併症頻度

  高野 史生, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2021, 日本眼科学会雑誌, 125(臨増) (臨増), 240 - 240, Japanese


• Granulomatosis with Polyangiitis Presenting with Bilateral Orbital Apex Syndrome.

  Yusuke Murai, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Kengo Akashi, Yuko Yamada-Nakanishi, Makoto Nakamura

  We report a rare case of granulomatosis with polyangiitis (GPA) presenting with bilateral orbital apex syndrome (OAS). A 73-year-old woman with a history of endoscopic sinus surgery for ethmoidal sinusitis experienced a sudden decrease in visual acuity (VA) of both eyes. At the initial examination, her VA had decreased to 0.01 in the right eye and 0.03 in the left eye, and eye movement in both eyes was mildly limited in all directions. Visual field tests of both eyes showed a large central scotoma. Laboratory tests revealed an elevation of myeloperoxidase-anti-neutrophil cytoplasmic antibody. Facial computed tomography demonstrated a thickened mucosal membrane in the entire ethmoidal sinus, and the posterosuperior walls of Onodi cells filled with infiltrative lesions had thinned. Orbital magnetic resonance imaging showed severe inflammation in the orbital apex. From these clinical findings, the patient was diagnosed with GPA presenting with OAS associated with ethmoid sinusitis. Emergent endoscopic sinus surgery was performed for biopsy and debridement of the ethmoidal and sphenoid sinusitis to decompress the optic nerve. One day after endoscopic sinus surgery, the patient's VA and visual field were improved, and steroid pulse therapy was commenced postoperatively. Four days later, VA had recovered to 1.0 in both eyes, and eye movement and visual field had were improved. Although OAS is a rare manifestation, early surgical treatment should be considered when the orbital lesion presents as risk of rapid deterioration of visual function in patients with GPA.

  2021, Case reports in ophthalmology, 12(1) (1), 32 - 40, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Efficacy for the Annual Relapse Rate after the Immunosuppressive Therapy in Patients Associated with Anti-AQP4 or Anti-MOG Antibody-Positive Optic Neuritis

  Sotaro Mori, Takuji Kurimoto, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Norio Chihara, Yuko Yamada-Nakanishi, Makoto Nakamura

  Purpose. Although oral prednisolone is the first-line treatment for preventing recurrent optic neuritis (ON) after the completion of acute-phase treatment, especially anti-aquaporin 4 (AQP4) antibody-positive ON, and anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive ON, some patients experience relapses. Immunosuppressants could be effective in reducing the recurrence rate for neuromyelitis optica spectrum disorder and MOG antibody-related diseases, but there have been few studies addressing this issue focusing on the changes in ophthalmic parameters. The objective of the study was to analyze the impact of off-label uses of immunosuppressants to reduce recurrent ON. Design. Retrospective observational study, clinical case series. Methods. We reviewed the medical charts of 11 cases (22 eyes) who underwent immunosuppressive therapy in Kobe University Hospital and compared the annualized relapse rate (ARR) before and after immunosuppressive therapy. We also evaluated the dosage of prednisolone, complications of immunosuppressants, and other visual functional ophthalmologic parameters. Results. Eleven cases in total had AQP4 antibody (9 cases) and/or MOG antibody (3 cases). One case was double positive for these antibodies. Nine patients received azathioprine and two received mycophenolate mofetil as an initial immunosuppressive therapy. The median duration of immunosuppressant treatment was 2.8 years. The median ON ARR before immunosuppressive therapy was 0.33, and this decreased significantly to 0 after the therapy ( $p=0.02$ ). The dose of prednisolone was reduced from 17.8 ± 7.1 mg/day before to 5.8 ± 2.2 mg/day after immunosuppressive therapy ( $p<0.01$ ). Although two patients presented with mild elevation of liver enzymes and nausea, all patients were able to continue taking the immunosuppressants. Conclusions. Immunosuppressants can potentially decrease relapses and steroid dosage in patients with anti-AQP4 or MOG antibody-positive ON without severe adverse events and the exacerbation of visual acuities.

  Hindawi Limited, Nov. 2020, Journal of Ophthalmology, 2020, 1 - 6

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• レーベル遺伝性視神経症における中心残存視野の評価

  岸本 真椰, 上田 香織, 高野 史生, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 55 - 55, Japanese


• 非機能性下垂体腺腫に対する内視鏡下経鼻的下垂体術後の初発例と再発例における視力変化の比較検討

  井之上 杏奈, 栗本 拓治, 魚住 洋一, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 谷口 理章, 中村 誠

  日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 71 - 71, Japanese


• 当院における眼窩先端部症候群12例の臨床像の検討

  村井 佑輔, 栗本 拓治, 高野 史生, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 72 - 72, Japanese


• サイトメガロウイルス虹彩毛様体炎続発緑内障の手術成績

  村井 佑輔, 盛 崇太朗, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 80 - 80, Japanese


• 血栓予防薬の緑内障手術における内服状況と術後の影響

  高野 史生, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 81 - 81, Japanese


• 緑内障眼におけるアイモ両眼ランダム測定の有用性の検討

  林 由紀子, 坂本 麻里, 高野 史生, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 166 - 166, Japanese


• 緑内障眼におけるアイモ両眼ランダム測定の中心窩感度および信頼係数の検討

  坂本 麻里, 高野 史生, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 166 - 166, Japanese


• A case of neurosarcoidosis presenting with multiple cranial neuropathies.

  Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Mari Sakamoto, Norio Chihara, Wataru Satake, Yuko Yamada-Nakanishi, Makoto Nakamura

  Purpose: We report a case of neurosarcoidosis that presented simultaneously with oculomotor nerve palsy, contralateral abducens nerve palsy, and paresthesia of both lower limbs. Observations: A 69-year-old Japanese woman who suffered from repeated diplopia and lower-limb paresthesia was referred to our hospital. Ophthalmic findings included oculomotor nerve and contralateral abducens nerve palsies. No remarkable abnormalities were detected via enhanced brain magnetic resonance imaging (MRI), chest X-ray, and cerebrospinal fluid analysis. Chest computed tomography (CT) was performed to exclude neoplastic lesions; this revealed right hilar lymphadenopathy, and positron emission tomography MRI showed strong 18-F fluorodeoxyglucose uptake in the hilar lymph node. Biopsy of the lymph node showed non-caseating epithelioid granulomatous tissue, leading to a diagnosis of probable neurosarcoidosis. After the initiation of oral prednisolone treatment, the patient experienced complete remission without any recurrence. Conclusions and importance: When examining a patient presenting with multiple cranial neuropathies of unknown cause, neurosarcoidosis should be considered as a differential diagnosis and chest CT should be performed even when the chest X-ray and angiotensin-converting enzyme appears normal.

  Sep. 2020, American journal of ophthalmology case reports, 19, 100796 - 100796, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• A Single-Arm, Prospective, Exploratory Study to Preliminarily Test Effectiveness and Safety of Skin Electrical Stimulation for Leber Hereditary Optic Neuropathy.

  Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Seiko Kamada, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

  Leber hereditary optic neuropathy (LHON) is an intractable disease associated with mitochondrial DNA (mtDNA) mutations. In this preliminary, single-arm, prospective, open-label exploratory trial, we investigated the effectiveness and safety of skin electrical stimulation (SES) for cases of LHON harboring the mtDNA 11,778 mutation. Of the 11 enrolled patients, 10 completed six sessions of SES once every two weeks over a 10-week period. The primary outcome measure was the change in logarithm of the minimum angle of resolution (logMAR)-converted best-corrected visual acuity (BCVA) at one week after the last session of SES. The main secondary outcome measures were the logMAR BCVA at four and eight weeks and Humphrey visual field test sensitivities at one, four, and eight weeks. At all follow-up points, the logMAR BCVA had improved significantly from baseline [1.80 (1.70–1.80) at baseline, 1.75 (1.52–1.80) at one week, 1.75 (1.50–1.80) at four weeks, and 1.75 (1.52–1.80) at eight weeks; p < 0.05]. At eight weeks of follow-up, five patients showed >2-fold increase in the summed sensitivity at 52 measurement points from baseline. No adverse effects were observed. In conclusion, SES could be a viable treatment option for patients with LHON in the chronic phase harboring the mtDNA 11,778 mutation.

  May 2020, Journal of clinical medicine, 9(5) (5), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 緑膿菌が原因の結膜炎から結膜欠損を引き起こした免疫健常な若年例

  山田 裕子, 上田 香織, 長井 隆行, 中西 裕子[山田], 中村 誠

  (株)医学書院, May 2020, 臨床眼科, 74(5) (5), 627 - 630, Japanese


• マイクロフックトラベクロトミーの切開範囲による術後短期成績の比較

  盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 212 - 212, Japanese


• 傾向スコア解析による毛様溝挿入アーメド/バルベルトインプラントの術後短期成績

  村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 216 - 216, Japanese


• 上皮増殖因子受容体チロシンキナーゼ阻害薬が原因と考えられる眼障害の検討

  曽谷 尭之, 山田 裕子, 鉄本 章, 盛 崇太朗, 坂本 麻里, 長井 隆行, 中村 誠

  (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 292 - 292, Japanese


• 高度な眼窩炎症と髄膜炎を併発した眼部帯状疱疹の1例

  佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太朗, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠

  日本神経眼科学会, Mar. 2020, 神経眼科, 37(1) (1), 38 - 44, Japanese


• 上皮増殖因子受容体チロシンキナーゼ阻害薬が原因と考えられる眼障害の検討

  曽谷 尭之, 山田 裕子, 鉄本 章, 盛 崇太朗, 坂本 麻里, 長井 隆行, 中村 誠

  (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 292 - 292, Japanese

  [Refereed]


• Scleral baring secondary to conjunctivitis by Pseudomonas aeruginosa in an immunologically healthy adult

  Hiroko Yamada, Kaori Ueda, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

  Igaku-Shoin Ltd, 2020, Japanese Journal of Clinical Ophthalmology, 74(5) (5), 627 - 630, Japanese

  Scientific journal


• A comparison of the 1-year surgical outcomes of ab externo trabeculotomy and microhook ab interno trabeculotomy using propensity score analysis.

  Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

  Objective: To compare the 1-year outcomes of trabeculotomy ab externo (ab externo TLO) and trabeculotomy ab interno using a microhook (ab interno TLO) for glaucoma patients using propensity score analysis. Methods and analysis: The medical charts of 65 consecutive patients who underwent ab externo TLO and those of 69 patients who underwent ab interno TLO were reviewed. Logistic regression analysis was conducted to calculate the propensity score using 1:1 matched analysis, which indicates the likelihood of surgical success at 12 months. We set the outcome-related covariates as age, glaucoma type, mean deviation, preoperative intraocular pressure (IOP), the number of preoperative glaucoma eye drops and the presence or absence of combined cataract surgery. Fifty eyes per each surgery group were subsequently compared. Results: The mean preoperative IOP was 32.5±11.2 mm Hg in the ab externo TLO group and 28.4±7.8 mm Hg in the ab interno TLO group (p=0.08). The mean postoperative IOP at 12 months was 18.3±7.4 mm Hg in the former group and 17.8±6.3 mm Hg in the latter (p=0.91). When surgical success was defined as a postoperative IOP of between 5 and 21 mm Hg with a more than 20% IOP reduction from baseline and no additional glaucoma surgery, the rate at 12 months was 78% in the ab externo TLO group and 74% in the ab interno TLO group (p=1.00). Conclusion: The 1-year success rate was not significantly different between ab externo and ab interno TLO.

  2020, BMJ open ophthalmology, 5(1) (1), e000446, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 動眼・滑車・外転神経麻痺

  中西(山田)裕子

  Oct. 2019, 臨床眼科 増刊号 実戦 メディカル眼科治療アップデート, 73(11) (11), 217 - 223, Japanese

  [Refereed]

  Scientific journal


• 毛様溝挿入アーメドインプラント手術の術後短期成績

  村井 佑輔, 盛 崇太朗, 栗本 拓治, 山田 裕子, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  日本緑内障学会, Sep. 2019, 日本緑内障学会抄録集, 30回, 77 - 77, Japanese


• 多発血管炎性肉芽腫症に伴う副鼻腔炎により発症した両側鼻性視神経症の一例

  村井 佑輔, 栗本 拓治, 河原 佳奈, 山田 裕子, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 76 - 76, Japanese


• 抗PD-L1抗体薬により視神経炎と下垂体機能低下症を来した一例

  山田 裕子, 栗本 拓治, 上田 香織, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠

  日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 88 - 88, Japanese


• En Face Slab Images Visualize Nerve Fibers With Residual Visual Sensitivity in Significantly Thinned Macular Areas of Advanced Glaucomatous Eyes.

  Mari Sakamoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura

  Purpose: The present study aimed to assess the ability of en face slab images of maculae to detect residual nerve fiber bundles in eyes with advanced glaucoma. Methods: This study included 36 eyes with diffuse thinning of the ganglion cell and inner plexiform layers (GCL+IPL). Inclusion criterion was GCL+IPL thickness of <1% of the normative database level as detected using optical coherence tomography (OCT). En face slab images (50-μm thickness) were reconstructed from the macular cube scan data using advanced visualization settings. Thereafter, we assessed the agreement of the locations between hyperreflective nerve fiber bundles and normal points in the Humphrey visual field test 10-2 pattern deviation (PD) plots. Additionally, total deviation (TD) corresponding to hyperreflective and hyporeflective areas was compared. Results: Hyperreflective areas were detected in 31 out of 36 eyes; all 31 eyes exhibited at least one normal PD point despite the substantial GCL+IPL thinning in the macular region. Two eyes with abnormalities in all PD points showed no hyperreflective area. The remaining three eyes had normal PD points despite the lack of high reflectivity areas in the slab images. Therefore, 91.7% of eyes showed agreement between en face slab images and PD plots. Moreover, hyperreflective areas demonstrated significantly better TD than hyporeflective areas. Conclusions: En face slab images of maculae were able to reveal the residual nerve fiber bundles in the eyes with advanced glaucoma despite the GCL+IPL thickness in the maculae being diffusely and substantially reduced.

  Jul. 2019, Investigative ophthalmology & visual science, 60(8) (8), 2811 - 2821, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 緑内障セミナー 小児緑内障の分類

  中西 裕子

  Jun. 2019, あたらしい眼科, 36(6) (6), 779 - 780, Japanese

  [Refereed]

  Scientific journal


• マイクロパルス波経強膜毛様体光凝固術の術後短期成績

  村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 258 - 258, Japanese


• 前眼部OCTにより鑑別を行った結膜粘液腫の1例

  山田 裕子, 長井 隆行, 中井 駿一朗, 坂本 麻里, 中村 誠

  (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 311 - 311, Japanese

  [Refereed]


• The Size of the Foveal Avascular Zone Is Associated with Foveal Thickness and Structure in Premature Children.

  Akiko Miki, Yuko Yamada, Makoto Nakamura

  Purpose: To investigate the foveal avascular zone (FAZ) in the eyes of patients with a history of retinopathy of prematurity (ROP) using optical coherence tomography angiography (OCTA) and to identify associated clinical factors. Patients and methods: Overall, 14 children with a history of laser treatment for ROP, 17 children born prematurely without a history of ROP, and 41 age-matched children born at full-term (age range 7-14 years) were included. OCTA was conducted on an area measuring 3 × 3 mm in the central macula. The area of FAZ in the superficial layer was measured. Foveal thickness (FT), ganglion cell complex thickness, and the presence of inner retinal layer (IRL) at the fovea were evaluated. Results: There were significant differences in FT and FAZ size among patients (P < 0.001). The eyes of patients that had been treated for ROP showed the smallest FAZ and greatest FT. Univariate analyses demonstrated that the area of FAZ was not correlated with visual acuity (P=0.078) but with gestational age (GA) (P=0.001), birth weight (P=0.013), the presence of IRL (P < 0.001), and FT (P < 0.001). Multivariate regression analyses showed that the area of FAZ was significantly associated with GA, the presence of IRL, and FT (P=0.03, P=0.01, P < 0.001, respectively). Conclusion: The eyes of preterm children had small FAZ, and this reduction in area was associated with greater FT, the presence of IRL, and lower GA.

  2019, Journal of ophthalmology, 2019, 8340729 - 8340729, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Relationship between vision-related quality of life and central 10° of the binocular integrated visual field in advanced glaucoma

  Yamazaki Y, Sugisaki K, Araie M, Kanamori A, Inoue T, Ishikawa S, Yoshikawa K, Maeda H, Yamada Y, Negi A, Inatani M, Tanihara H, Okinami S, Mizuki K, Mishima K, Uchida K, Matsumoto S

  2019, Scientific Reports, 18(9) (9), 14990, English

  [Refereed]

  Scientific journal


• Discordance of disc-fovea raphe angles determined by optical coherence tomography and MP-3 microperimetry in eyes with a glaucomatous hemifield defect

  Mori S, Kurimoto T, Kanamori A, Sakamoto M, Ueda K, Yamada-Nakanishi Y, Nakamura M

  2019, Investigative ophthalmology & visual science, 60(5) (5), 1403 - 1411, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The difficulty of diagnosing invasive aspergillosis initially manifesting as optic neuropathy

  Mori S, Kurimoto T, Kawara K, Ueda K, Sakamoto M, Keshi Y, Yamada-Nakanishi Y, Tachibana H, Nakamura M

  BACKGROUND: Invasive aspergillosis is often fatal. Here, we report a patient with invasive aspergillosis primarily involving the optic nerve diagnosed on autopsy. CASE PRESENTATION: A 77-year-old female with underlying diabetes mellitus, hyperlipidemia, and hypertension presented with disc swelling of the left eye. Although mini-pulse steroid therapy improved visual acuity (VA) of the left eye, it abruptly decreased to no light perception within a month, followed by a decrease in VA of the right eye to 0.5. At referral, VA was 0.3 in the right eye, and there was no light perception in the left eye. RESULTS: Fundus examination revealed optic disc swelling of both eyes. Goldmann perimetry showed irregular visual field defects, whereas magnetic resonance imaging (MRI), general, and cerebrospinal fluid (CSF) examinations revealed no distinct abnormalities. We suspected anterior ischemic optic neuropathy and invasive optic neuropathy. As with the left eye, steroid pulse therapy temporarily improved VA of the right eye and then decreased to 0.2. Additional anticoagulant therapy did not improve VA. Concurrent to therapy, the patient became febrile with depressed consciousness. Repeat MRI identified suspected midbrain infarction, and CSF examination indicated cerebral meningitis. In spite of administering transfusions and antibiotics, she died on hospital day 40. Autopsy revealed large amounts of Aspergillus hyphae mainly localized in the dura mater of the optic nerve and destruction of the cerebral artery wall, suggesting an etiology of subarachnoid hemorrhage. CONCLUSIONS: When examining refractory and persistent disc swelling, we should rule out fungal infections of the optic nerve.

  2019, Case Reports in Ophthalmology, 10(1) (1), 11 - 18, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A study protocol for evaluating the efficacy and safety of skin electrical stimulation for Leber hereditary optic neuropathy: a single-arm, open-label, non-randomized prospective exploratory study.

  Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura

  Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES. Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision. Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.

  2019, Clinical ophthalmology (Auckland, N.Z.), 13(13) (13), 897 - 904, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Case of Multi-System Langerhans Cell Histiocytosis with Local Invasion of the Orbital Apex

  Hiroko Yamada, Takuji Kurimoto, Sotaro Mori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Yoichi Uozumi, Hiroyasu Shose, Masaaki Taniguchi, Masanori Toyoda, Hironobu Minami, Makoto Nakamura

  2019, CASE REPORTS IN OPHTHALMOLOGY, 10(3) (3), 319 - 326, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 片眼の動眼神経麻痺と僚眼の外転神経麻痺を呈したサルコイドーシスの1例

  盛 崇太朗, 栗本 拓治, 荒木 健, 坂本 麻里, 上田 香織, 大塚 喜久, 芥子 結香子, 佐竹 渉, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 79 - 79, Japanese


• 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の1例

  佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太郎, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠

  日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 87 - 87, Japanese

  [Refereed]


• Effectiveness and safety of sulcus fixation of Baerveldt glaucoma implants in glaucomatous eyes in patients who underwent multiple intraocular surgeries

  Mori S, Sakamoto M, Kurimoto T, Kanamori A, Ueda K, Inoue Y, Yamada Yuko, Nakamura Makoto

  Oct. 2018, Graefes Arch Clin Exp Ophthalmol, 256(10) (10), 1953 - 1960, English

  [Refereed]

  Scientific journal


• レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価

  Ueda Kaori, 盛崇太朗, 坂本麻里, 芥子結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto

  Sep. 2018, 神経眼科, 35(3号) (3号), 303 - 308, Japanese

  [Refereed]

  Scientific journal


• 【続発緑内障】 続発小児緑内障

  Yamada Yuko

  Aug. 2018, あたらしい眼科, 35(8号) (8号), 1057 - 1065, Japanese

  [Refereed][Invited]

  Scientific journal


• Vasculitis with superior ophthalmic vein thrombosis compatible with neuro-neutrophilic disease

  Sakamoto M, Kurimoto T, Mori S, Ueda Kaori, Keshi Y, Yamada Yuko, Azumi A, Shimono T, Nakamura Makoto

  PURPOSE: To present a unique case of neuro-neutrophilic disease with inflammation and thrombosis of the superior ophthalmic vein (SOV). OBSERVATIONS: A 43-year-old Japanese man with past histories of oculomotor paralysis, auditory disorder, ischemic enteritis, and recurrent oral ulceration was referred to our hospital because of blurred vision in his right eye. Ophthalmic examination revealed decreased best corrected visual acuity and central scotoma in his right eye. Orbit magnetic resonance imaging (MRI) revealed an enlarged SOV in the right eye, with Gadolinium (Gd) enhancement in the wall of the vein but not inside the vein, indicating thrombosis. Multiple Gd-enhanced hyperintense lesions were also observed in the juxtacortical area of the brain. We diagnosed the patient with vasculitis in the right SOV that was adversely affecting the optic nerve. We ruled out systemic thrombophilia, infections, and malignancy by systemic examinations. The human leukocyte antigen (HLA) typing was Cw1-, B54-, B61-, A2-, A24-, and DR4-positive and B51-negative. We treated the patient with systemic steroid and anticoagulant therapy. After three courses of steroid pulse therapy, his symptoms and the MRI findings of the right SOV and brain improved; therefore, we decided to discontinue the anticoagulant therapy. One month after anticoagulant cessation, MRI revealed recurrence of the thrombus and enlargement of the right SOV despite the lack of vision worsening. We restarted the anticoagulant therapy while continuing the oral prednisolone treatment. At the final visit, 14 months after the onset of the disease, the patient was still receiving oral anticoagulation with warfarin potassium and prednisolone (5 mg/day). His symptoms and the right eye's visual function remained normal with a mildly enlarged SOV; there was less Gd enhancement and no brain lesions on MRI. CONCLUSIONS AND IMPORTANCE: We treated a unique case of possible neuro-neutrophilic disease that presented visual disturbances due to right SOV inflammation and thrombosis. Anticoagulation and systemic steroid therapies were required to reduce the inflammation and to prevent the recurrence of thrombosis.

  Aug. 2018, Am J Ophthalmol Case Rep, 12, 39 - 44, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 緑内障眼における他覚的・自覚的機能検査結果とEn Face slab画像を用いた構造評価結果の相関性の検討

  井上結香子, 鎌田誠子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, Yamada Yuko, 中村誠

  Jul. 2018, 眼科臨床紀要, 11(7号) (7号), 555, Japanese

  [Refereed]

  Scientific journal


• Optic Neuritis Possibly Induced by Anti-PD-L1 Antibody Treatment in a Patient with Non-Small Cell Lung Carcinoma

  Mori S, Kurimoto T, Ueda Kaori, Enomoto H, Sakamoto M, Keshi Y, Yamada Yuko, Nakamura Makoto

  BACKGROUND: Recent immune therapy with checkpoint inhibitors (CPIs) has demonstrated remarkable antitumor effects on specific tumors, such as malignant lymphoma and non-small cell lung carcinoma. By contrast, CPIs cause an imbalance in the immune system, triggering a wide range of immunological side effects termed immune-related adverse effects (irAEs). Here, we report a rare case of optic neuritis and hypopituitarism during anti-programmed death-ligand 1 (PD-L1) antibody treatment. CASE PRESENTATION: A patient with non-small cell lung carcinoma received anti-PD-L1 antibody treatment every 3 weeks; however, the patient started experiencing headaches, general fatigue, anorexia, and diarrhea approximately 1 year after the initiation of the treatment. Moreover, sudden visual loss of the right eye occurred 1 week after the interruption of the anti-PD-L1 antibody treatment. MRI findings showed gadolinium enhancement in the left optic nerve, but no enlargement of the pituitary gland and stalk. Laboratory data showed decreased serum adrenocorticotropic hormone (ACTH), cortisol, and free T4 levels, and a hormone tolerance test indicated hypopituitarism, hypothyroidism, and hypoadrenocorticism. The central scotoma caused by optic neuritis completely disappeared immediately after a course of steroid pulse therapy, and no recurrence occurred up to 2 years after initiation of the steroid pulse therapy while replacement therapy for hypothyroidism and hypoadrenocorticism was continued. CONCLUSIONS: The patient presented with optic neuritis and hypopituitarism, possibly due to irAEs of the anti-PD-L1 antibody treatment. Steroid pulse therapy was effective for optic neuritis, suggesting underlying immunological mechanisms. Neurological complications including optic neuritis should be considered when examining patients with cancer undergoing CPI treatment.

  Jul. 2018, Case Rep Ophthalmol, 9(2) (2), 348 - 356, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 緑内障眼における他覚的・自覚的機能検査結果とen face slab画像を用いた構造評価結果の相関性の検討

  井上結香子, 鎌田誠子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, Yamada Yuko, 中村誠

  Mar. 2018, 日本眼科学会雑誌, 122(3号) (3号), 252 - 253, Japanese

  [Refereed]

  Scientific journal


• 未熟児網膜症既往眼における中心窩無血管領域と固視点安定性の関連

  林田真由香, 三木明子, 中西理恵, 島内深希, 和田友紀, 井上結香子, Yamada Yuko, 中村誠

  Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 307, Japanese

  [Refereed]

  Scientific journal


• Evaluation of central scotoma based on stimulus size of the visual field test in patients with leber hereditary optic neuropathy

  Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yukako Keshi, Takuji Kurimoto, Yuko Yamada, Makoto Nakamura

  Neuro-Ophthalmology Society of Japan, 2018, Neuro-Ophthalmology Japan, 35(3) (3), 303 - 308, Japanese

  Scientific journal


• Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity.

  Akiko Miki, Shigeru Honda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

  PURPOSE: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). METHODS: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. RESULTS: The ROP group demonstrated the worst VA and the shallowest foveal depression. Furthermore, foveal depression significantly correlated with birth weight, GA, ganglion cell layer/inner plexiform layer (GCL-IPL) thickness, and a history of ROP. CONCLUSIONS: This study established a correlation of fovea formation with premature birth, damage of GCL-IPL, and a history of ROP. The retention of the inner retina possibly contributes to abnormal foveal morphology in patients with a history of ROP.

  2018, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 240(2) (2), 106 - 110, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Excessive scleral shrinkage, rather than choroidal thickening, is a major contributor to the development of hypotony maculopathy after trabeculectomy

  Mari Sakamoto, Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  Public Library of Science, Jan. 2018, PLoS ONE, 13(1) (1), e0191862, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Diagnostic utility of combined retinal ganglion cell count estimates in Japanese glaucoma patients

  Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  Springer Tokyo, Jan. 2018, Japanese Journal of Ophthalmology, 62(1) (1), 31 - 40, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 視神経鞘髄膜腫に対し強度変調放射線治療を施行した神経線維腫症2型の一例

  松野裕樹, Yamada Yuko, 井上結香子, 金森章泰, Nakamura Makoto

  Dec. 2017, 神経眼科, 34(4号) (4号), 449 - 454, Japanese

  [Refereed]

  Scientific journal


• 未熟児網膜症既往眼における中心窩無血管体についての検討

  三木明子, 中西理恵, 上田香織, 井上結香子, Yamada Yuko, Honda Shigeru, 中村誠

  Nov. 2017, 眼科臨床紀要, 10(11号) (11号), 949, Japanese

  [Refereed]

  Research society


• 両視神経症の診断に苦慮し剖検にて侵襲性アスペルギルス症と診断された一例

  盛崇太朗, 栗本拓治, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

  Oct. 2017, 神経眼科, 34(増補1) (増補1), 66, Japanese

  [Refereed]

  Symposium


• 上眼静脈血栓性静脈炎により視力低下・視野障害を生じた一例

  坂本麻里, 盛崇太朗, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

  Oct. 2017, 神経眼科, 34(増補1) (増補1), 110, Japanese

  [Refereed]

  Symposium


• レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価

  上田香織, 盛崇太朗, 坂本麻里, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

  Oct. 2017, 神経眼科, 34(増補1) (増補1), 75, Japanese

  [Refereed]

  Symposium


• ぶどう膜炎と視神経症を発症し、生検にて確定診断に至った結核性肥厚性硬膜炎の1例

  崔龍東, 栗本拓治, 盛崇太朗, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

  Oct. 2017, 神経眼科, 34(増補1) (増補1), 106, Japanese

  [Refereed]

  Symposium


• 下垂体腫瘍患者における光干渉断層計と静的視野検査および多局所視覚誘発電位の異常検出の一致性

  井上結香子, 盛崇太朗, 上田香織, 坂本麻里, 栗本拓治, 金森章泰, Yamada Yuko, 中村誠

  Jul. 2017, 眼科臨床紀要, 10(7号) (7号), 585 - 586, Japanese

  [Refereed]

  Scientific journal


• [Home Monitoring of Intraocular Pressure and it's Diurnal Patterns Using Icare® HOME].

  Mari Sakamoto, Akiyasu Kanamori, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Yuko Yamada, Makoto Nakamura

  Purpose: To evaluate Icare® HOME for home monitoring of intraocular pressure (IOP) and to observe diurnal IOP patterns for a short term. Patients and methods: Twenty six eyes of 16 patients with open angle glaucoma were included. After instruction and practice in using Icare® HOME, patients were asked to measure their IOP by themselves at home or in a sick room. Patients measured their IOP four times a day with a four hour interval between each measurement for three days. Patients repeated measurements until three successful measurements were obtained at each time. Intra-rater reliability was assessed calculating intraclass correlation coefficient (ICC) of the three measurements. Diurnal IOP patterns were assessed for three days. Results: No adverse events occurred. ICC of three measurements was 0.76 (95% confidence coefficient; 0.71 to 0.81). The median of the difference between the highest and the lowest IOP during a day was 4.26 mmHg (95% CI; 4.06 to 4.67). Repeatable patterns were not found in diurnal IOP for three days. Three out of ten patients who answered the questionnaire after measurements found difficulties in handling the device. Conclusions: Although Icare® HOME is safe and could be used for home monitoring of IOP, some patients had difficulties in using the instrument. Diurnal IOP patterns did not show repeatability during a short term.

  Apr. 2017, Nippon Ganka Gakkai zasshi, 121(4) (4), 366 - 72, Japanese, Domestic magazine

  Scientific journal


• Icare HOMEを用いた眼圧のホームモニタリングおよび日内変動の検討

  坂本麻里, 金森章泰, 盛崇太郎, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto

  日本眼科学会, Apr. 2017, 日本眼科学会雑誌, 121(4号) (4号), 366 - 372, Japanese

  [Refereed]

  Scientific journal


• 流出路再建術の術式別術後短期成績の比較検討

  盛崇太朗, 金森章泰, 坂本麻里, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, 中村誠

  Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 245, Japanese

  [Refereed]

  Symposium


• 健常眼における視神経乳頭中心窩線と耳側縫線の解剖学的位置関係の検討

  栗本拓治, 盛崇太朗, 金森章泰, 若林星太, 中西理恵, 坂本麻里, 上田香織, 井上結香子, Yamada Yuko, 中村誠

  Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 209, Japanese

  [Refereed]

  Symposium


• Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis

  Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura

  Feb. 2017, PLOS ONE, 12(2) (2), e0171880, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A case of optic nerve sheath meningioma treated with intensity-modulated radiotherapy in neurofibromatosis type 2

  Yuki Matsuno, Yuko Yamada, Yukako Inoue, Akiyasu Kanamori, Makoto Nakamura

  Neuro-Ophthalmology Society of Japan, 2017, Neuro-Ophthalmology Japan, 34(4) (4), 449 - 454, Japanese

  Scientific journal


• 抗AQP4抗体陽性視神経炎に対する血液浄化療法の治療効果

  盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 千原 典夫, 金森 章泰, 山田 裕子, 中村 誠

  日本神経眼科学会, Oct. 2016, 神経眼科, 33(増補1) (増補1), 86 - 86, Japanese

  [Refereed]


• Schlemm管内皮網除去と深層強膜弁切除を併施した線維柱帯切開術の術後成績

  安田絵里子, 金森章泰, 上田香織, 明石梓, 坂本麻里, 井上結香子, Yamada Yuko, Nakamura Makoto

  日本眼科学会, Sep. 2016, 日本眼科学会雑誌, 120(9号) (9号), 635 - 639, Japanese

  [Refereed]

  Scientific journal


• All-trans retinoic acidによる偽脳腫瘍を呈した急性前骨髄性白血病の一例

  広瀬 美樹, 山田 裕子, 明石 梓, 松本 佳子, 三木 明子, 井上 結香子, 金森 章泰, 中村 誠

  眼科臨床紀要会, Apr. 2016, 眼科臨床紀要, 9(4) (4), 375 - 375, Japanese

  [Refereed]


• 乳頭周囲網膜神経線維層厚の菲薄化の有無による極早期緑内障の層別化

  明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 164 - 164, Japanese


• 視神経炎における抗AQP4抗体の構造と機能に与える影響

  松本 佳子, 明石 梓, 上田 香織, 坂本 麻里, 井上 結香子, 金森 章泰, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 194 - 194, Japanese


• IcareHOMEを用いた患者による自己眼圧測定の再現性と日内変動の検討

  坂本 麻里, 金森 章泰, 上田 香織, 明石 梓, 井上 結香子, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 304 - 304, Japanese


• The Ability of SD-OCT to Differentiate Early Glaucoma With High Myopia From Highly Myopic Controls and Nonhighly Myopic Controls

  Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura

  Oct. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(11) (11), 6573 - 6580, English

  [Refereed]

  Scientific journal


• Evaluation of the distribution pattern of the circumpapillary retinal nerve fibre layer from the nasal hemiretina

  Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura

  Oct. 2015, BRITISH JOURNAL OF OPHTHALMOLOGY, 99(10) (10), 1419 - 1423, English

  [Refereed]

  Scientific journal


• Optic disc swelling as the initial manifestation in a case of lung adenocarcinoma

  Tomonori Kanai, Masaya Nisizaki, Yuko Yamada, Kiyonobu Kanamori, Masumi Tanabe, Akiyasu Kanamori, Makoto Nakamura

  Igaku-Shoin Ltd, Sep. 2015, Japanese Journal of Clinical Ophthalmology, 69(9) (9), 1395 - 1399, Japanese

  International conference proceedings


• トラベクレクトミー術後低眼圧黄斑症の発症危険因子の検討

  坂本 麻里, 井上 結香子, 松本 佳子, 明石 梓, 上田 香織, 金森 章泰, 山田 裕子, 中村 誠

  日本緑内障学会, Sep. 2015, 日本緑内障学会抄録集, 26回, 100 - 100, Japanese


• 3種のSD-OCTのPre-perimetric glaucomaにおける検出力の比較について

  明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠

  日本緑内障学会, Sep. 2015, 日本緑内障学会抄録集, 26回, 143 - 143, Japanese


• 非高度近視正常眼と高度近視正常眼の高度近視早期緑内障に対するOCT検出力の相違

  明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 310 - 310, Japanese


• シュレム管内皮網除去+深層強膜弁切除を併施したトラベクロトミーの術後成績

  安田 絵里子, 金森 章泰, 上田 香織, 明石 梓, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 316 - 316, Japanese


• 未熟児網膜症既往眼の黄斑部における光干渉断層計所見と関連因子の検討

  三木 明子, 本田 茂, 島脇 由香, 松本 佳子, 明石 梓, 山田 裕子, 中村 誠

  (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 290 - 290, Japanese

  [Refereed]


• Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments

  Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yuki Kawaka, Yuko Yamada, Makoto Nakamura

  Jan. 2015, JAPANESE JOURNAL OF OPHTHALMOLOGY, 59(1) (1), 55 - 64, English

  [Refereed]

  Scientific journal


• アクアポリン9は乳酸輸送を介して網膜神経節細胞の生存を制御する

  明石 梓, 三木 明子, 井上 結香子, 金森 章泰, 山田 裕子, 中村 誠

  日本緑内障学会, Sep. 2014, 日本緑内障学会抄録集, 25回, 114 - 114, Japanese

  [Refereed]


• The Detection of Macular Analysis by SD-OCT for Optic Chiasmal Compression Neuropathy and Nasotemporal Overlap

  Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura

  Jul. 2014, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(7) (7), 4667 - 4672, English

  [Refereed]

  Scientific journal


• Dexamethasone tachyphylaxis in the treatment of macular oedema

  Mari Sakamoto, Akiyasu Kanamori, Masashi Fujihara, Yuko Yamada, Makoto Nakamura, Akira Negi

  May 2014, ACTA OPHTHALMOLOGICA, 92(3) (3), 243 - 248, English

  [Refereed]

  Scientific journal


• Effect of axial length reduction after trabeculectomy on the development of hypotony maculopathy

  Yoshiko Matsumoto, Masashi Fujihara, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  May 2014, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58(3) (3), 267 - 275, English

  [Refereed]

  Scientific journal


• Assessment of IcareONE rebound tonometer for self-measuring intraocular pressure

  Mari Sakamoto, Akiyasu Kanamori, Masashi Fujihara, Yuko Yamada, Makoto Nakamura, Akira Negi

  Blackwell Publishing Ltd, 2014, Acta Ophthalmologica, 92(3) (3), 243 - 248, English

  [Refereed]

  Scientific journal


• Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

  Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi

  Jul. 2013, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(7) (7), 4478 - 4484, English

  [Refereed]

  Scientific journal


• 長期経過において形態変化を認めた網膜つた状血管腫の1例

  三木 明子, Yamada Yuko, 金森 章泰, 中村 誠, 根木 昭

  May 2013, 眼科臨床紀要, 6(5号) (5号), 408, Japanese

  Research society


• Structure-function relationship among three types of spectral-domain optical coherent tomography instruments in measuring parapapillary retinal nerve fibre layer thickness

  Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi

  May 2013, ACTA OPHTHALMOLOGICA, 91(3) (3), E196 - E202, English

  [Refereed]

  Scientific journal


• 小児緑内障 小児緑内障における治療とその選択

  Yamada Yuko

  Mar. 2013, Frontiers in Glaucoma, (45号) (45号), 33 - 35, Japanese

  Symposium


• 3種のSD-OCTの乳頭周囲網膜神経線維層厚と視野の相関

  明石 梓, 金森 章泰, 坂本 麻里, 藤原 雅史, Yamada Yuko, 中村 誠, 根木 昭

  Mar. 2013, 日本眼科学会雑誌, 117(臨増) (臨増), 334, Japanese

  Research society


• Spectral-domain optical coherence tomography detects optic atrophy due to optic tract syndrome

  Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi

  Feb. 2013, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 251(2) (2), 591 - 595, English

  [Refereed]

  Scientific journal


• 3種のSD-OCTによる視神経乳頭周囲網膜神経層厚における各象限の比較

  Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  Jan. 2013, 日本視能訓練士協会誌, 41, 286, Japanese

  Research society


• The ability of macular parameters and circumpapillary retinal nerve fiber layer by three SD-OCT instruments to diagnose highly myopic glaucoma

  Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi

  2013, Investigative Ophthalmology and Visual Science, 54(9) (9), 6025 - 6032, English

  [Refereed]

  Scientific journal


• Cluster analyses of grid-pattern display in macular parameters using optical coherence tomography for glaucoma diagnosis

  Akiyasu Kanamori, Maiko Naka, Azusa Akashi, Masashi Fujihara, Yuko Yamada, Makoto Nakamura

  2013, Investigative Ophthalmology and Visual Science, 54(9) (9), 6401 - 6408, English

  [Refereed]

  Scientific journal


• 小脳髄膜腫により腫瘍随伴性視神経症を発症した一例

  Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira

  Oct. 2012, 神経眼科, 29(増補1) (増補1), 59, Japanese

  Research society


• Better performance of RTVue than Cirrus spectral-domain optical coherence tomography in detecting band atrophy of the optic nerve

  Makoto Nakamura, Kumiko Ishikawa-Tabuchi, Akiyasu Kanamori, Yuko Yamada, Akira Negi

  Oct. 2012, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 250(10) (10), 1499 - 1507, English

  [Refereed]

  Scientific journal


• 小児緑内障 小児緑内障における治療とその選択

  Yamada Yuko

  Sep. 2012, 日本緑内障学会抄録集23回, 53, Japanese

  Research society


• 自己眼圧測定器icareONEの精度および安全性の検討

  Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  Sep. 2012, 日本緑内障学会抄録集23回, 153, Japanese

  Research society


• ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討

  Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  Sep. 2012, 日本緑内障学会抄録集23回, 116, Japanese

  Research society


• 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較

  Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  Sep. 2012, 日本緑内障学会抄録集23回, 155, Japanese

  Research society


• Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy

  Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi

  Aug. 2012, ARCHIVES OF OPHTHALMOLOGY, 130(8) (8), 1067 - 1069, English

  [Refereed]

  Scientific journal


• Effects of ocular rotation on parapapillary retinal nerve fiber layer thickness analysis measured with spectral-domain optical coherence tomography

  Akiyasu Kanamori, Makoto Nakamura, Kumiko Tabuchi, Yuko Yamada, Akira Negi

  Jul. 2012, JAPANESE JOURNAL OF OPHTHALMOLOGY, 56(4) (4), 354 - 361, English

  [Refereed]

  Scientific journal


• Agreement among three types of spectral-domain optical coherent tomography instruments in measuring parapapillary retinal nerve fibre layer thickness

  Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi

  Jun. 2012, BRITISH JOURNAL OF OPHTHALMOLOGY, 96(6) (6), 832 - 837, English

  [Refereed]

  Scientific journal


• Sweet's syndrome with panuveitis resembling Behçet's disease.

  Wataru Matsumiya, Sentaro Kusuhara, Yozo Yamada, Atsushi Azumi, Akira Negi

  PURPOSE: Sweet's syndrome (SS) is a skin disorder clinically characterized by fever, neutrophilia, and painful edematous plaques that occasionally causes posterior uveitis. We present two cases of SS with panuveitis resembling Behçet's disease (BD). SUBJECTS: Two patients with panuveitis associated with SS. OBSERVATIONS: The patient in case 1 was a 57-year-old Japanese man who developed acute severe iritis with hypopyon in the left eye. Fluorescein angiography (FA) performed 1 month after treatment showed findings observed in posterior uveitis: dye leakage from the optic disc and a petaloid pattern of hyperfluorescence in the macular region. The patient in case 2 was a 64-year-old Japanese man who complained of blurred vision in his left eye. Faint flare and occasional cells were present in the left anterior chamber, 2+ cells in the anterior vitreous, and 2+ vitreous opacification in the left eye. FA demonstrated dye leakage from the optic disc and peripheral capillary vessels in both eyes. Both patients were diagnosed as having SS on the basis of fever, neutrophilia, elevated C-reactive protein, and skin biopsy results of neutrophilic infiltration without vasculitis. CONCLUSIONS: Differentiation of SS from BD based on the ocular manifestations is difficult. Ophthalmologists should bear in mind that SS can exhibit panuveitis resembling BD.

  May 2012, Japanese journal of ophthalmology, 56(3) (3), 268 - 72, English, Domestic magazine

  [Refereed]

  Scientific journal


• 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化

  Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  Mar. 2012, 日本眼科学会雑誌, 116(臨増) (臨増), 361, Japanese

  Research society


• Filtering Bleb Structure Associated with Long-Term Intraocular Pressure Control after Amniotic Membrane-Assisted Trabeculectomy

  Makoto Nakamura, Maiko Naka, Yasuko Tatsumi, Azusa Nagai-Kusuhara, Akiyasu Kanamori, Yuko Yamada, Akira Negi

  Mar. 2012, CURRENT EYE RESEARCH, 37(3) (3), 239 - 250, English

  [Refereed]

  Scientific journal


• 二種のスペクトラル・ドメイン光干渉断層計のband atrophy検出能と一致性の検討

  Yamada Yuko

  Oct. 2011, 神経眼科, 28巻, 増補1, pp. 80-80, Japanese

  International conference proceedings


• 乳頭周囲網膜神経線維層厚における眼球回旋の影響

  Yamada Yuko

  Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 99-99, Japanese

  International conference proceedings


• 眼内レンズ嚢内固定眼に生じた色素緑内障の一例

  Yamada Yuko

  Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 126-126, Japanese

  International conference proceedings


• 3種のスペクトラルドメイン光干渉断層計による視神経乳頭周囲網膜神経層厚の相関と一致性

  Yamada Yuko

  Sep. 2011, 日本緑内障学会抄録集22回, 巻, , pp. 95-95, Japanese

  International conference proceedings


• 当院における視神経鞘髄膜腫の検討

  Yamada Yuko

  Jun. 2011, 眼科, 53巻, 6号, pp. 830-830, Japanese

  International conference proceedings


• 多チャンネル多局所視覚誘発電位と視野の緑内障眼における構造変化との関連

  Yamada Yuko

  Jun. 2011, 眼科臨床紀要, 4巻, 6号, pp. 583-584, Japanese

  International conference proceedings


• Postural changes in intraocular pressure are associated with asymmetrical retinal nerve fiber thinning in treated patients with primary open-angle glaucoma

  Junji Mizokami, Yuko Yamada, Akira Negi, Makoto Nakamura

  Jun. 2011, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 249(6) (6), 879 - 885, English

  [Refereed]

  Scientific journal


• 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

  Yamada Yuko

  May 2011, 眼科臨床紀要, 4巻, 5号, pp. 472-472, Japanese

  International conference proceedings


• Optimal conditions for multifocal VEP recording for normal Japanese population established by receiver operating characteristic analysis

  Kumiko Ishikawa, Takayuki Nagai, Yuko Yamada, Akira Negi, Makoto Nakamura

  Feb. 2011, DOCUMENTA OPHTHALMOLOGICA, 122(1) (1), 29 - 37, English

  [Refereed]

  Scientific journal


• 性ホルモン薬の長期内服が誘引と思われる脳静脈洞血栓症の1例

  Yamada Yuko

  Nov. 2010, 神経眼科, 27巻, 増補1, pp. 86-86, Japanese

  International conference proceedings


• 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

  Yamada Yuko

  Oct. 2010, 日本眼科学会雑誌, 114巻, 10号, pp. 891-891, Japanese

  International conference proceedings


• Melanoma-Associated Retinopathyの1例

  Yamada Yuko

  Oct. 2010, 眼科臨床紀要, 3巻, 10号, pp. 1021-1021, Japanese

  International conference proceedings


• 日本人の正常眼における多チャンネル多局所視覚誘発電位の検討

  Yamada Yuko

  Jul. 2010, 眼科臨床紀要, 3巻, 7号, pp. 701-702, Japanese

  International conference proceedings


• 多チャンネル多局所視覚誘発電位による緑内障検出能の検討

  Yamada Yuko

  Mar. 2010, 日本眼科学会雑誌, 114巻, 臨増, pp. 335-335, Japanese

  International conference proceedings


• 内境界膜剥離併用硝子体手術がラタノプロストによる黄斑浮腫のトリガーとなった正常眼圧緑内障の一例

  Yamada Yuko

  Nov. 2009, 日本緑内障学会抄録集20回, 巻, , pp. 142-142, Japanese

  International conference proceedings


• 小児白内障術後無水晶体眼における中心角膜厚の検討

  Yamada Yuko

  Jun. 2009, 眼科臨床紀要, 2巻, 6号, pp. 564-564, Japanese

  International conference proceedings


• ディスポーザブルプリズムによるゴールドマン圧平眼圧計の測定値評価

  Yamada Yuko

  Mar. 2009, 日本眼科学会雑誌, 113巻, 臨増, pp. 276-276, Japanese

  International conference proceedings


• A case of bilateral, idiopathic optic neuritis with a unique course in childhood

  Kumiko Ishikawa, Yasuko Tatsumi, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura

  2009, Neuro-Ophthalmology Japan, 26(3) (3), 307 - 313, Japanese

  Scientific journal


• Serous Macular Detachment Due to Diabetic Papillopathy Detected Using Optical Coherence Tomography

  Makoto Nakamura, Akiyasu Kanamori, Azusa Nagai-Kusuhara, Sentrao Kusuhara, Yuko Yamada, Akira Negi

  Jan. 2009, ARCHIVES OF OPHTHALMOLOGY, 127(1) (1), 105 - 107, English

  [Refereed]

  Scientific journal


• Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity in Glaucomatous Eyes

  Akiyasu Kanamori, Maiko Naka, Azusa Nagai-Kusuhara, Yuko Yamada, Makoto Nakamura, Akira Negi

  Nov. 2008, ARCHIVES OF OPHTHALMOLOGY, 126(11) (11), 1500 - 1506, English

  [Refereed]

  Scientific journal


• Disagreement between Heidelberg Retina Tomograph and optical coherence tomography in assessing optic nerve head configuration of eyes with band atrophy and normal eyes

  A. Nagai-Kusuhara, M. Nakamura, Y. Tatsumi, Y. Nakanishi, A. Negi

  Oct. 2008, BRITISH JOURNAL OF OPHTHALMOLOGY, 92(10) (10), 1382 - 1386, English

  [Refereed]

  Scientific journal


• Evaluation of optic nerve head configuration in various types of optic neuropathy with Heidelberg Retina Tomograph

  A. Nagai-Kusuhara, M. Nakamura, A. Kanamori, Y. Nakanishi, S. Kusuhara, Akira Negi

  Sep. 2008, EYE, 22(9) (9), 1154 - 1160, English

  [Refereed]

  Scientific journal


• 異なる手術術式を選択した高度近視に伴う進行性内斜視の母子例

  Yamada Yuko

  Mar. 2008, 眼科臨床紀要, 1巻, 3号, pp. 270-271, Japanese

  International conference proceedings


• Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells

  Yamada Yuko

  Jan. 2008, Journal Of Neurochemistry, Vol. 105, No. 4, pp. 1187-97, English

  Scientific journal


• Retinal nerve fiber layer thickness in optic tract syndrome

  Y Tatsumi, A Kanamori, A Kusuhara, Y Nakanishi, S Kusuhara, M Nakamura

  Jul. 2005, JAPANESE JOURNAL OF OPHTHALMOLOGY, 49(4) (4), 294 - 296, English

  Scientific journal


• Long-term glial reactivity in rat retinas ipsilateral and contralateral to experimental glaucoma

  A Kanamori, M Nakamura, Y Nakanishi, Y Yamada, A Negi

  Jul. 2005, EXPERIMENTAL EYE RESEARCH, 81(1) (1), 48 - 56, English

  Scientific journal


• Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs

  A Kanamori, M Nakamura, N Matsui, A Nagai, Y Nakanishi, S Kusuhara, Y Yamada, A Negi

  Dec. 2004, OPHTHALMOLOGY, 111(12) (12), 2278 - 2283, English

  [Refereed]

  Scientific journal


• Akt is activated via insulin/IGF-1 receptor in rat retina with episcleral vein cauterization

  A Kanamori, M Nakamura, Y Nakanishi, A Nagai, H Mukuno, Y Yamada, A Negi

  Oct. 2004, BRAIN RESEARCH, 1022(1-2) (1-2), 195 - 204, English

  [Refereed]

  Scientific journal


• 神経線維腫症に合併した先天緑内障の1例

  福村美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  Aug. 2004, 眼科臨床医報, 98巻, 8号, pp. 687-690, Japanese

  [Refereed]

  Scientific journal


• 緑内障眼における上下半視野の網膜神経線維層厚の光干渉断層計による解析

  KANAMORI,Akiyasu, 瀬谷隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  Apr. 2004, 日本眼科学会雑誌, 108巻, 4, pp. 213-218, Japanese

  Scientific journal


• 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少

  曽和 美幸, 楠原 仙太郎, 永井 あづさ, 中西 頼子, 金森 章泰, 山田 裕子, 中村 誠, 根木 昭, 関谷 善文

  日本神経眼科学会, Dec. 2003, 神経眼科, 20(増補1) (増補1), 43 - 43, Japanese

  [Refereed]


• Band atrophyにおけるOCTによる網膜神経線維層厚の解析

  松井 敬子, 金森 章泰, 永井 あづさ, 中西 頼子, 楠原 仙太郎, 山田 裕子, 中村 誠, 関谷 善文, 根木 昭

  日本神経眼科学会, Dec. 2003, 神経眼科, 20(増補1) (増補1), 47 - 47, Japanese

  [Refereed]


• 視索症候群の網膜神経線維層厚

  辰巳 康子, 金森 章泰, 中西 頼子, 永井 あづさ, 楠原 仙太郎, 山田 裕子, 中村 誠, 関谷 善文, 根木 昭

  日本神経眼科学会, Dec. 2003, 神経眼科, 20(増補1) (増補1), 79 - 79, Japanese

  [Refereed]


• 動脈瘤性骨嚢胞の1例

  Yamada Yuko

  Feb. 2003, 眼科臨床医報, 97巻, 2号, pp. 132-132, Japanese

  International conference proceedings


• Zoster sine herpete with bilateral ocular involvement

  Makoto Nakamura, Masumi Tanabe, Yuko Yamada, Atsushi Azumi

  2000, American Journal of Ophthalmology, 129(6) (6), 809 - 810, English

  [Refereed]

  Scientific journal

• 眼虚血症候群を合併した,維持腹膜透析の3歳男児例

  石森 真吾, 山本 和宏, 篠本 匡志, 大西 聡, 服部 有香, 堀之内 智子, 上田 香織, 中西 裕子, 起塚 庸

  (一社)日本腎臓学会, Sep. 2023, 日本腎臓学会誌, 65(6-W) (6-W), 794 - 794, Japanese


• ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した1例

  山田 裕子, 栗本 拓治, 盛 崇太朗, 坂本 麻里, 上田 香織, 中井 友昭, 魚住 洋一, 豊田 晶徳, 中西 裕子, 中村 誠

  日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 84 - 84, Japanese


• 【緑内障診療に役立つ検査ノウハウ】 ゴールドマン視野計

  Yamada Yuko

  Oct. 2017, OCULISTA, (55号) (55号), 55 - 65, Japanese

  Introduction commerce magazine


• 視野異常を診断する 4. 遺伝性視神経症

  Yamada Yuko, 中村誠

  Dec. 2015, 眼科, 57(13) (13), 1653 - 1660, Japanese

  [Invited]

  Introduction scientific journal


• 【緑内障なんでも質問箱-エキスパートに聞いたら最新エビデンスをもとにズバリと答えてくれた!】 治療編 手術 濾過手術 羊膜を用いたトラベクレクトミーのメリット・デメリットについて教えてください

  Yamada Yuko

  Oct. 2015, 臨床眼科, 69(11号) (11号), 307 - 311, Japanese

  [Invited]

  Introduction scientific journal


• 視神経乳頭腫脹を契機として発見された肺線癌の１例

  金井友範, 西崎雅也, Yamada Yuko, 金森斎修, 田邊益美, Kanamori Akiyasu, Nakamura Makoto

  Sep. 2015, 臨床眼科, 69(9) (9), 1395 - 1399, Japanese

  [Refereed]

  Report scientific journal


• The Ability of SD-OCT to Differentiate Early Glaucoma in Highly Myopia from Highly Myopic Control

  Akiyasu Kanamori, Azusa Akashi, Kaori Ueda, Mari Sakamoto, Yukako Inoue, Yuko Yamada, Makoto Nakamura

  Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English

  Summary international conference


• The OCT findings of macula and associated factors in patients with a history of retinopathy of prematurity

  Akiko Miki, Shigeru Honda, Yoshiko Matsumoto, Azusa Akashi, Yuko Yamada, Makoto Nakamura

  Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English

  Summary international conference


• Trabeculotomy with Schlemm's canal endothelium removal and deep sclerectomy

  Eriko Yasuda, Akiyasu Kanamori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Yuko Yamada, Makoto Nakamura

  Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English

  Summary international conference


• 【エキスパートからノウハウを学ぶ!弱視・斜視スペシャルノート[疾患と治療編]】 弱視の治療

  Yamada Yuko

  Oct. 2014, 眼科ケア, 16(10号) (10号), 924 - 930, Japanese

  Introduction scientific journal


• 視神経疾患の新しい展開

  根木 昭, 中村 誠, 金森 章泰, 楠原 あづさ, 中西 頼子, 辰巳 康子, 藤岡 美幸, 田口 真衣子, 福田 昌秀, 田渕 久美子, 三木 明子, 溝上 淳二, 長井 隆行, 藤原 雅史, Yamada Yuko

  (公財)日本眼科学会, Mar. 2013, 日本眼科学会雑誌, 117(3) (3), 187 - 211, Japanese

  Introduction scientific journal


• 緑内障3分診療を科学する! 乳頭の脆弱性 血管系と「100日」

  Yamada Yuko

  Oct. 2012, 眼科, 54(11号) (11号), 1654 - 1658, Japanese

  Introduction scientific journal


• 目でみるシリーズ 続・読影シリーズ(第5回) 紛らわしい例(その2) 眼底の異常(血管異常を含む)を伴う例

  Yamada Yuko

  Sep. 2012, Frontiers in Glaucoma, (44号) (44号), 109 - 116, Japanese

  Introduction scientific journal


• 災害時における緑内障診療

  Negi Akira, Yamada Yuko

  Sep. 2012, Frontiers in Glaucoma, (44号) (44号), 126 - 134, Japanese

  Others


• 【基礎知識がバッチリ!実践でそのまま役立つ斜視・弱視の原因、検査、治療】 病気について知ろう 弱視ってどんな病気?

  Yamada Yuko

  Aug. 2012, 眼科ケア, 14(8号) (8号), 704 - 708, Japanese

  Introduction scientific journal


• 緑内障研究の進歩 緑内障性視神経症への挑戦 新しい病態論の提唱と他覚的機能解析方法の改良

  Nakamura Makoto, Naka Maiko, Nagai Takayuki, Kanamori Akiyasu, Yamada Yuko, Negi Akira

  (公財)日本眼科学会, Mar. 2012, 日本眼科学会雑誌, 116(3) (3), 298 - 346, Japanese

  [Refereed][Invited]

  Introduction scientific journal


• A Reply to KOSAKA's and NAGAE's Comments on "Psychological Independence in University Students : Factors and Correlations with Adjustment"

  YAMADA Yuko

  Japan Society of Youth and Adolescent Psychology, 2012, The Japanese Journal of Adolescent Psychology, 24(1) (1), 54 - 59, Japanese


• 緑内障セミナー 羊膜移植併用緑内障手術

  Yamada Yuko

  Jun. 2011, あたらしい眼科, 28巻, 6号, pp. 827-828, Japanese

  Introduction scientific journal


• Psychological Independence in University Students Factors and Correlations with Adjustment

  YAMADA Yuko

  The purpose of this study was to organize and define the concept of psychological independence in university students, and to examine its correlations with several influential factors and psychological adjustment. Psychological independence was defined as "exercising emotional, cognitive, and behavioral control over one's life, and being responsible for one's own behavior". The participants were 329 university students, who filled out a questionnaire. As the result of a factor analysis, psychological independence was distilled into 5 factors, namely "building self, "emotional control", "self-determination and responsibility", "positive attitude to life", and "unattained individuality". The results of a multiple regression analysis suggested: 1) psychological independence was significantly correlated with basic trust in both genders; 2) psychological independence in females was correlated positively with distant associations with friends; 3) emotional support from fathers was correlated negatively with psychological independence in females, whereas emotional support from mothers was positively correlated; and 4) in males there was little correlation between psychological independence and interpersonal factors. Another multiple regression analysis suggested that psychological independence was correlated with maladjustment, besides adjustment. The limitations and implications are discussed.

  Japan Society of Youth and Adolescent Psychology, 2011, The Japanese Journal of Adolescent Psychology, 23(1) (1), 1 - 18, Japanese


• 【不定愁訴の子どもを診るために】 症状に応じたアプローチ 目が見えない(視覚障害)

  Yamada Yuko

  Jan. 2011, 小児科診療, 74巻, 1号, pp. 68-74, Japanese

  Others


• 【覚えておきたい! 眼圧検査で異常値が出る原因】 高眼圧の原因

  Yamada Yuko

  Jul. 2010, 眼科ケア, 12巻, 7号, pp. 654-662, Japanese

  Others


• 目で見るシリーズ 読影シリーズ まぎらわしい例(その2) 血管異常を含む眼底異常に伴う例

  Yamada Yuko

  Dec. 2009, Frontiers in Glaucoma, 10巻, 3号, pp. 101-105, Japanese

  Introduction scientific journal


• 【目の病気における看護ケアのポイント 入院治療を要する重症眼疾患を対象に】 知っておきたい知識 先天性眼疾患 先天白内障、発達緑内障、眼瞼下垂

  Yamada Yuko

  Dec. 2008, 小児看護, 31巻, 13号, pp. 1734-1739, Japanese

  Others


• 【患児と親へのよりよい対応のために子どもの目の病気とケア】 実践編 子どもの検査をマスターしよう 形態評価

  Yamada Yuko

  Jun. 2007, 眼科ケア, 巻, 2007夏季増刊, pp. 210-225, Japanese

  Others


• 【緑内障の患者説明 正しい知識を伝えるための3ステップ】 疾患・検査・治療についての正しい知識を身に付ける! 緑内障ではこんな治療を行う

  Yamada Yuko

  Feb. 2007, 眼科ケア, 9巻, 2号, pp. 154-164, Japanese

  Others


• Macular thickness reduction in eyes with unilateral optic atrophy detected with optical coherence tomography

  S. Kusuhara, M. Nakamura, A. Nagai-Kusuhara, Y. Nakanishi, A. Kanamori, A. Negi

  Aug. 2006, EYE, 20(8) (8), 882 - 887, English


• Prediction of postoperative visual outcome based on hole configuration by optical coherence tomography idiopathic macular in eyes with holes

  S Kusuhara, MFT Escano, S Fujii, Y Nakanishi, Y Tamura, A Nagai, H Yamamoto, Y Tsukahara, A Negi

  Nov. 2004, AMERICAN JOURNAL OF OPHTHALMOLOGY, 138(5) (5), 709 - 716, English


• Evaluation of successful macular hole surgery by multifocal electroretinography

  Y Tamura, S Kusuhara, Y Nakanishi, K Yamada, MFT Escano, H Yamamoto, Y Tsukahara, A Negi

  Apr. 2004, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45, U405 - U405, English

  Summary international conference


• 小学校低学年児童の近視

  YAMADA, Yuko

  2004, 臨床眼科, 58巻, 2, pp. 125-129, Japanese

  Introduction scientific journal


• 【眼科疾患別パーフェクト検査マニュアル】 疾患別検査の進め方 緑内障の検査

  YAMADA, Yuko, 調廣子

  Dec. 2003, 眼科ケア, 2003年冬季増刊, pp. 76-101, Japanese

  Others

• 眼疾患アトラスシリーズ第2巻 後眼部アトラス

  近藤, 峰生, 辻川, 明孝, 大鹿, 哲郎

  脳眼動静脈つた状血管腫症（Wyburn-Mason症候群）, 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786862

  Scholarly book


• 眼疾患アトラスシリーズ第2巻 後眼部アトラス

  近藤, 峰生, 辻川, 明孝, 大鹿, 哲郎

  神経線維腫症（von Recklinghausen病）, 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786862

  Scholarly book


• 眼疾患アトラスシリーズ第3巻 外眼部アトラス

  野田, 実香, 渡辺, 彰英, 大鹿, 哲郎

  部分調節性内斜視, 総合医学社, Oct. 2019, Japanese, ISBN: 9784883786879

  Scholarly book


• 眼科検査ガイド第2版 / 9．視野検査 10)神経眼科疾患の視野検査 ４．中心フリッカー値

  Yamada Yuko

  Others, 文光堂, Sep. 2016, Japanese

  Scholarly book


• 眼科検査ガイド第2版 / 5．眼位・眼球運動検査 1)眼位検査 ４．固視検査

  Yamada Yuko

  Others, 文光堂, Sep. 2016, Japanese

  Scholarly book


• 眼科検査ガイド第2版 / 5．眼位・眼球運動検査 1)眼位検査 ３．単眼性眼位検査

  Yamada Yuko

  Others, 文光堂, Sep. 2016, Japanese

  Scholarly book


• 眼科検査ガイド第2版 / 5．眼位・眼球運動検査 1)眼位検査 ２．眼位定量検査

  Yamada Yuko

  Others, 文光堂, Sep. 2016, Japanese

  Scholarly book


• 眼科検査ガイド第2版 / 5．眼位・眼球運動検査 1)眼位検査 １．眼位定性検査

  Yamada Yuko

  Others, 文光堂, Sep. 2016, Japanese

  Scholarly book


• 眼科臨床エキスパートシリーズ 緑内障治療のアップデート / 発達緑内障、小児続発緑内障

  Yamada Yuko

  Others, 医学書院, Oct. 2015, Japanese

  Scholarly book


• 眼科臨床エキスパートシリーズ 緑内障治療のアップデート / 難治例の攻略法 小児緑内障

  Yamada Yuko

  Others, 医学書院, Oct. 2015, Japanese

  Scholarly book


• 眼手術学 緑内障 / 小児の緑内障濾過手術

  Yamada Yuko

  Others, 文光堂, Jan. 2012, Japanese

  Scholarly book


• 眼手術学 緑内障 / 小児の流出路再建術

  Yamada Yuko

  Others, 文光堂, Jan. 2012, Japanese

  Scholarly book


• 眼科プラクティス / 【眼科薬物治療A to Z】 副作用と毒性 乳幼児・小児への投与時の注意点

  Yamada Yuko

  Joint work, 文光堂, Sep. 2008, Japanese

  Scholarly book


• 眼科プラクティス / 【小児眼科診療】 疾患特性と診療指針 緑内障 発達緑内障

  Yamada Yuko

  Joint work, 文光堂, Mar. 2008, Japanese

  Scholarly book


• Frontiers in Glaucoma 8巻4号 Page200-201 / 緑内障とは 眼の構造・機能

  Yamada Yuko

  Joint work, メディカルレビュー社, Dec. 2007, Japanese

  Scholarly book


• 眼科プラクティス / 【緑内障診療の進めかた】 基礎知識 無作為化比較試験から得たエビデンス EGPS

  Yamada Yuko

  Joint work, 文光堂, Sep. 2006, Japanese

  Scholarly book


• 小児眼科・診療の最前線 / 大脳皮質一次視覚野の可塑性

  Yamada Yuko

  Joint work, 金原出版, Apr. 2003, Japanese

  Scholarly book


• 先端医療シリーズ23眼科 眼科の最新医療 / 白内障手術の進歩 ８ 小児ＩＯＬ

  YAMADA, Yuko

  Joint work, 先端技術研究所, 2003, Japanese

  Scholarly book


• 先端医療シリーズ23眼科 眼科の最新医療 / 白内障手術の進歩 ８ 小児ＩＯＬ

  Yamada Yuko

  Joint work, 先端医療技術研究所, 2003, Japanese

  Scholarly book


• 眼科ケア2003冬季増刊 眼科疾患別パーフェクトマニュアル / 緑内障検査

  YAMADA, Yuko, 調 廣子

  Joint work, メディカ出版, 2003, Japanese

  Scholarly book


• 改訂第３版眼科ナースのための知識と実際 / 小児眼疾患と看護

  YAMADA, Yuko

  Joint work, メディカ出版, 2003, Japanese

  Scholarly book

• 緑内障手術 ～神戸大学における現状と課題～

  中西(山田) 裕子

  東灘区眼科講演＆甲南医療センター眼科 病診連携の会, Dec. 2019, Japanese, Domestic conference

  Public discourse


• 両眼開放下視野測定により診断した片眼性心因性視覚障害の2例

  土橋 一生, 盛 崇太朗, 中西 裕子, 上田 香織, 坂本 麻里, 栗本 拓治, 中村 誠

  兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference

  Oral presentation


• 毛様溝挿入バルベルトインプラント手術の中長期成績

  曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference

  Oral presentation


• 緑膿菌が原因の結膜炎から結膜欠損を引き起こした免疫健常な若年例

  山田 裕子, 上田 香織, 長井 隆行, 中西 裕子, 中村 誠

  第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference

  Poster presentation


• 毛様溝挿入バルベルトインプラント手術の術後中長期成績

  曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference

  Oral presentation


• 多発血管炎性肉芽腫症に伴う副鼻腔炎により発症した両側鼻性視神経症の一例

  村井 佑輔, 栗本 拓治, 河原 佳奈, 山田 裕子, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference

  Oral presentation


• 抗PD-L1抗体薬により視神経炎と下垂体機能低下症を来した一例

  山田 裕子, 栗本 拓治, 上田 香織, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠

  第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference

  Poster presentation


• 再発性視神経炎に対する免疫抑制剤の治療効果

  盛 崇太朗, 栗本 拓治, 村井 佑輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子, 中村 誠

  第57回日本神経眼科学会総会, Oct. 2019, Japanese

  Oral presentation


• 教育講演2【緑内障病型ごとのアプローチ】小児緑内障へのアプローチ

  中西 裕子

  第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference

  Oral presentation


• 毛様溝挿入アーメドインプラント手術の術後短期成績

  村井 佑輔, 盛 崇太朗, 栗本 拓治, 山田 裕子, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠

  第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference

  Oral presentation


• En face slab imaging を用いた後期緑内障眼の構造と機能の解析

  坂本 麻里, 盛 崇太, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠

  第8回日本視野画像学会学術集会, May 2019, Japanese

  Oral presentation


• 小児眼科 Q&A

  中西(山田) 裕子

  第4回 瓜坊の会, May 2019, Japanese, Domestic conference

  Public discourse


• OCTによる上方視神経部分低形成の診断の試み

  金森 章泰, 若林 星太, 金森 敬子, 盛 崇太朗, 栗本 拓治, 中西 裕子, 中村 誠

  第123回日本眼科学会総会, Apr. 2019, Japanese, Domestic conference

  Oral presentation


• マイクロパルス波経強膜毛様体光凝固の使用経験

  村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠

  第123回日本眼科学会総会, Apr. 2019, Japanese, Domestic conference

  Poster presentation


• 片眼の動眼神経麻痺と僚眼の外転神経麻痺を呈したサルコイドーシスの1例

  盛 崇太朗, SAKAMOTO MARI, 上田 香織, KURIMOTO TAKUJI, NAKANISHI YUKO, NAKAMURA MAKOTO

  第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例

  佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花久嗣, NAKAMURA MAKOTO

  第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例

  佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花 久嗣, NAKAMURA MAKOTO

  第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した 1 例

  山田 裕子, KURIMOTO TAKUJI, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, 中井 友昭, 魚住 洋一, 豊田 晶徳, NAKANISHI YUKO, NAKAMURA MAKOTO

  第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• サイトメガロウイルス虹彩炎に起因する続発性緑内障 15 例の臨床像

  村井 佑輔, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, KURIMOTO TAKUJI, KUSUHARA SENTARO, NAKANISHI YUKO, NAKAMURA MAKOTO

  第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• Agreement of a nasal step border by a microperimeter with a temporal raphe by optical coherence tomography in glaucoma patients

  Sotaro Mori, Mari Sakamoto, Takuji Kurimoto, Kaori Ueda, Yuko Nakanishi, Makoto Nakamura

  23rd International visual field and imaging symposium, May 2018, English, 石川, Domestic conference

  Poster presentation


• SD-OCTによる黄斑部解析の視交叉圧迫性視神経症の検出力

  Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, 松本 佳子, 坂本 麻里, 近藤 陽子, Yamada Yuko, Nakamura Makoto

  The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference

  Oral presentation


• SD-OCTによる黄斑部解析での 菲薄化プロットパターンによる初期緑内障眼検出能

  中 真衣子, Kanamori Akiyasu, 明石 梓, 冨岡 真理, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto

  The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference

  Oral presentation


• 3種のSD-OCTの黄斑部パラメータと視野の相関

  冨岡 真里, Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto

  The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference

  Oral presentation


• Comparative assessment for the ability of macular parameters and circumpapillary retinal nerve fiber layer measured by three spectral-domain optical coherence tomograpahy insrtuments to diagnose glaucoma with high myopia

  明石 梓, Kanamori Akiyasu, Nakamura Makoto, Fujihara Masashi, Yamada Yuko, Negi Akira

  ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conference

  Oral presentation


• 3種のSD-OCTの乳頭周囲網膜神経線維層と視野の相関

  明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

  Oral presentation


• 小脳髄膜腫より腫瘍随伴性視神経症を発症した1例

  中野 沙弥, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira

  JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference

  Oral presentation


• Spectral-domain OCTを用いたSSOHの網膜内構造の評価

  大西 健, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference

  Oral presentation


• 3種の光干渉断層計で測定した高眼圧症，Pre-perimetric glaucomaにおける視神経乳頭周囲網膜神経層厚の比較

  明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference

  Oral presentation


• 小児緑内障における治療とその選択

  Yamada Yuko

  The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

  Public symposium


• 自己眼圧測定器IcareONE®の精度および安全性の検討

  坂本 麻里, Kanamori Akiyasu, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

  Oral presentation


• ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討

  松本 佳子, Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

  Oral presentation


• 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較

  明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference

  Oral presentation


• 長期経過において形態変化を認めた網膜つた状血管腫の一例

  Miki Akiko, Yamada Yuko, Kanamori Akiyasu, Nakamura Makoto, Negi Akira

  JASA2012, Jun. 2012, Japanese, Japanese Association of Strabismus and Amblyopia, 名古屋, Domestic conference

  Oral presentation


• 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化

  Kanamori Akiyasu, 田渕 久美子, 近藤 陽子, Yamada Yuko, Nakamura Makoto, Negi Akira

  The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

  Oral presentation


• 「緑内障3分診療を科学する！」視神経乳頭の脆弱性：血管系と「100日」

  Yamada Yuko

  The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference

  Public discourse


• Differential diagnosis of pediatric glaucoma

  Yamada Yuko

  The 27th APAO/SOE Congress, Apr. 2012, English, The Korean Ophthalmological Society, Busan,Korea, International conference

  Oral presentation


• 二種のスペクトラル・ドメイン光干渉断層計のband atrophy検出能と一致性の検討

  Nakamura Makoto, 田渕 久美子, Kanamori Akiyasu, Yamada Yuko

  第49回日本神経眼科学会, Nov. 2011, Japanese, 兵庫医科大学, 神戸, Domestic conference

  Oral presentation


• 3種の光干渉断層計で測定した視神経乳頭線維層の緑内障検出能の比較検討

  Kanamori Akiyasu, 冨岡 真里, 河賀 友紀, 田渕 久美子, Yamada Yuko, Nakamura Makoto, Negi Akira

  第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference

  Oral presentation


• 3種のスペクトラルドメイン光干渉断層計による視神経乳頭周囲網膜神経層厚の相関と一致性

  河賀 友紀, 冨岡 真里, 石川 久美子, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira

  第22回日本緑内障学会, Sep. 2011, Japanese, 日本緑内障学会, 秋田, Domestic conference

  Oral presentation


• Differences in filtering bleb structure associated with long-term intraocular pressure control between trabeculectomy with and without amniotic membrane transplantation.

  Nakamura Makoto, 中 真衣子, Yamada Yuko, Negi Akira

  世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference

  Oral presentation


• A comparison of long-term outcomes between trabeculectomy with and without amniotic membrane transplantation for intractable glaucoma

  Yamada Yuko, Nakamura Makoto, Negi Akira

  世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference

  Oral presentation


• 補助材料（薬剤）を利用した緑内障手術 羊膜移植を用いた緑内障手術

  Yamada Yuko

  第21回日本緑内障学会, Sep. 2010, Japanese, 日本緑内障学会, 福岡, Domestic conference

  Oral presentation


• 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について

  Yamada Yuko, Nakamura Makoto, 石川 久美子, 溝上 淳二, Negi Akira

  第66回日本弱視斜視学会総会・第35回日本小児眼科学会総会合同学会, Jul. 2010, Japanese, 日本斜視弱視学会・日本小児眼科学会, 東京, Domestic conference

  Oral presentation


• A phase I study of sorafenib (BAY 43-9006) in combination with S-1 plus cisplatin in patients with advanced gastric cancer.

  Yamada Yuko, Minami Hironobu, Fuse N, Ohtsu A, kato K, Kiyota Naomi, Shimada Y, Doi T, Nakajima T, Hamaguchi T, Fujiwara Y, Itoh Y, Mera K

  21st EORTH-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Nov. 2009, English, AACR, Boston, 米国, International conference

  Poster presentation


• 羊膜移植併用濾過手術の術後短期成績

  永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第２７回日本眼科手術学会総会, Jan. 2004, Japanese, 日本眼科手術学会, 東京, Domestic conference

  Oral presentation


• 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少

  曽和 美幸, KUSUHARA, Sentaro, 永井 あづさ, 中西 頼子, KANAMORI,Akiyasu, YAMADA, Yuko, NAKAMURA, Makoto, NEGI, Akira, SEKIYA,Yoshibumi

  第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

  Oral presentation


• 視索症候群の網膜神経線維層厚

  辰巳 康子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira

  第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

  Oral presentation


• Band atrophyにおけるOCTによる網膜神経線維層厚の解析

  松井 敬子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira

  第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference

  Oral presentation


• 線維柱帯切除術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較～

  永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第５７回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference

  Oral presentation


• 線維柱帯切除術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較

  永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第６９回日本中部眼科学会、第１００回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、中国四国眼科学会, 岡山, Domestic conference

  Oral presentation


• 線維柱帯切開術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較～

  永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第１０３回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference

  Oral presentation


• 上下半視野による光干渉断層計を用いた網膜神経線維層厚の解析

  KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第６９回日本中部眼科学会、第１００回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、, 岡山, Domestic conference

  Oral presentation


• 上下半視野におけるOCTによる網膜神経線維層厚の解析

  KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第５７回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference

  Oral presentation


• 上下半視野におけるOCTによる網膜神経線維層厚の解析

  KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第１０３回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference

  Oral presentation


• 眼圧変動に伴い視神経乳頭陥凹が著明な変化を繰り返した成人症例

  角谷 庸子, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference

  Oral presentation


• ラット慢性緑内障モデル網膜におけるAktの発現及びリン酸化

  KANAMORI,Akiyasu, 椋野 洋和, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference

  Oral presentation


• 神経線維腫症に合併した先天緑内障の１例

  福村 美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷 隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira

  第５９回日本弱視斜視学会総会、第２８回日本小児眼科学会総会合同学会, Jun. 2003, Japanese, 日本弱視斜視学会、日本小児眼科学会, 神戸, Domestic conference

  Oral presentation

• 日本緑内障学会


• 日本神経眼科学会


• 日本弱視斜視学会


• 日本小児眼科学会


• 日本眼科学会

• 網膜・視神経変性疾患におけるアクアポリンの関わり

  中村 誠

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017

  Competitive research funding


• 眼圧依存性視神経障害の発症メカニズムの解明と他覚的解析方法の確立

  根木 昭

  科学研究費補助金／基盤研究(B), 2010

  Competitive research funding