Research activity information

• The 14-3-3γ isoform binds to and regulates the localization of endoplasmic reticulum (ER) membrane protein TMCC3 for the reticular network of the ER

  Suhda S, Yamamoto Y, Wisesa S, Sada R, Sakisaka T

  Feb. 2023, Journal of Biological Chemistry, 299(2) (2), 102813

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Lunapark ubiquitinates atlastin-2 for the tubular network formation of the endoplasmic reticulum

  Anggrandariyanny PC, Kajiho H, Yamamoto Y, Sakisaka T

  Oct. 2022, The Journal of Biochemistry, 172(4) (4), 245 - 257

  [Refereed]


• Trans-2-enoyl-CoA reductase limits Ca2+ accumulation in the endoplasmic reticulum by inhibiting the Ca2+ pump SERCA2b

  Uchida Y, Yamamoto Y, Sakisaka T

  Elsevier BV, Jan. 2021, Journal of Biological Chemistry, 296, 100310, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• TMCC3 localizes at the three-way junctions for the proper tubular network of the endoplasmic reticulum.

  Wisesa S, Yamamoto Y, Sakisaka T

  Oct. 2019, Biochemical Journal, 476(21) (21), 3241 - 3260, English, International magazine

  [Refereed]

  Scientific journal


• CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.

  Kajiho H, Yamamoto Y, Sakisaka T

  Sep. 2019, Scientific reports, 9(1) (1), 13152, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• The peroxisome biogenesis factors posttranslationally target reticulon homology domain-containing proteins to the endoplasmic reticulum membrane

  Yasunori Yamamoto, Toshiaki Sakisaka

  Lead, Feb. 2018, Scientific reports, 8(1) (1), 2322, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The number of the C-terminal transmembrane domains has the potency to specify subcellular localization of Sec22c

  Yamamoto Yasunori, YurugiC, Sakisaka Toshiaki

  Lead, May 2017, Biochem Biophys Res Commun, 487(2) (2), 388 - 395, English, International magazine

  [Refereed]

  Scientific journal


• The emerging role of calcium-modulating cyclophilin ligand in posttranslational insertion of tail-anchored proteins into the endoplasmic reticulum membrane

  Yasunori Yamamoto, Toshiaki Sakisaka

  Lead, Jun. 2015, The Journal of Biochemistry, 157(6) (6), 419 - 429, English, International magazine

  [Refereed]

  Scientific journal


• Identification and Characterization of TMEM33 as a Reticulon-binding Protein

  Urade T, Yamamoto Yasunori, Zhang X, Ku Yonson, Sakisaka Toshiaki

  Nov. 2014, Kobe J Med Sci, 60(3) (3), E57 - 65, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• VAP-B Binds to Rab3GAP1 at the ER: Its Implication in Nuclear Envelope Formation through the ER-Golgi Intermediate Compartment

  Hantan D, Yamamoto Yasunori, Sakisaka Toshiaki

  Oct. 2014, Kobe J Med Sci, 60(3) (3), E48 - 56, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion

  Yamamoto Yasunori, Yoshida A, Miyazaki N, Iwasaki K, Sakisaka Toshiaki

  Lead, Feb. 2014, Biochemical Journal, 458(1) (1), 69 - 79, English, International magazine

  [Refereed]

  Scientific journal


• Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells

  Yamamoto Yasunori, Sakisaka Toshiaki

  Lead, Nov. 2012, Molecular Cell, 48(3) (3), 387 - 397, English, International magazine

  [Refereed]

  Scientific journal


• Crystal Structure of the cis-Dimer of Nectin-1: implications for the architecture of cell-cell junctions

  Narita H*, Yamamoto Y* (*equal contribution), Suzuki M, Miyazaki N, Yoshida A, Kawai K, Iwasaki K, Nakagawa A, Takai Y, Sakisaka T

  Lead, Apr. 2011, The Journal of Biological Chemistry, Vol. 286, No. 14, pp. 12659-69, English, International magazine

  [Refereed]

  Scientific journal


• Refolding, crystallization and preliminary X-ray crystallographic study of the whole extracellular regions of nectins

  Hirotaka Narita, Atsushi Nakagawa, Yasunori Yamamoto, Toshiaki Sakisaka, Yoshimi Takai, Mamoru Suzuki

  Mar. 2011, Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 67, No. Pt 3, pp. 344-8, English, International magazine

  [Refereed]

  Scientific journal


• Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth

  Kurooka Takao, Yamamoto Yasunori, Takai Yoshimi, Sakisaka Toshiaki

  Feb. 2011, The Journal of Biological Chemistry, Vol. 286, No. 8, pp. 6832-43, English, International magazine

  [Refereed]

  Scientific journal


• Tomosyn inhibits synaptotagmin-1-mediated step of Ca2 -dependent neurotransmitter release through its N-terminal WD40 repeats

  Yamamoto Y, Mochida S, Miyazaki N, Kawai K, Fujikura K, Kurooka T, Iwasaki K, Sakisaka T

  Lead, Dec. 2010, The Journal of Biological Chemistry, Vol. 285, No. 52, pp. 40943-55, English, International magazine

  [Refereed]

  Scientific journal


• The tail domain of tomosyn controls membrane fusion through tomosyn displacement by VAMP2

  Yamamoto Y, Fujikura K, Sakaue M, Okimura K, Kobayashi Y, Nakamura T, Sakisaka T

  Lead, Aug. 2010, Biochem Biophys Res Commun, Vol. 399, No. 1, pp. 24-30, English, International magazine

  [Refereed]

  Scientific journal


• Sar1 assembly regulates membrane constriction and ER export

  Long KR*, Yamamoto Y* (*equal contribution), Baker AL, Watkins SC, Coyne CB, Conway JF, Aridor M

  Lead, Jul. 2010, The Journal of Cell Biology, Vol. 190, No. 1, pp. 115-28, English, International magazine

  [Refereed]

  Scientific journal


• Reciprocal intramolecular interactions of tomosyn control its inhibitory activity on SNARE complex formation

  Yasunori Yamamoto, Sumiko Mochida, Takao Kurooka, Toshiaki Sakisaka

  Lead, May 2009, The Journal of Biological Chemistry, Vol. 284, No. 18, pp. 12480-12, English, International magazine

  [Refereed]

  Scientific journal


• Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release

  Toshiaki Sakisaka*, Yasunori Yamamoto* (*equal contribution), Sumiko Mochida, Michiko Nakamura, Kouki Nishikawa, Hiroyoshi Ishizaki, Miki Okamoto-Tanaka, Jun Miyoshi, Yoshinori Fujiyoshi, Toshiya Manabe, Yoshimi Takai

  Lead, Oct. 2008, The Journal of Cell Biology, Vol. 183, No. 2, pp. 323-37, English, International magazine

  [Refereed]

  Scientific journal

• 【テイルアンカー型タンパク質の細胞内輸送と膜挿入機構:現代生物学に残された謎の一つがいま解かれる】 テイルアンカー型タンパク質のトランスロコン非依存的な小胞体輸送・膜挿入機構

  Yamamoto Yasunori, Sakisaka Toshiaki

  Lead, Jul. 2013, 細胞工学, 32(8号) (8号), 845 - 850, Japanese, Domestic magazine

  [Invited]

  Introduction commerce magazine


• 【SNARE複合体-膜融合の機構】 トモシンによるSNARE複合体の制御機構

  Yamamoto Yasunori, Sakisaka Toshiaki

  Lead, Jun. 2010, 生体の科学, 61巻, 3号, pp. 233-241, Japanese, Domestic magazine

  [Invited]

  Introduction scientific journal


• 【融合発展する構造生物学とケミカルバイオロジーの最前線】 ターゲットタンパク研究プログラムの成果 細胞接着装置構成蛋白質の構造生物学的研究 Lglファミリー分子トモシンによる小胞融合の制御機構

  Yamamoto Yasunori, Sakisaka Toshiaki

  Lead, Sep. 2009, 蛋白質・核酸・酵素, 54巻, 12号, pp. 1647-1653, Japanese, Domestic magazine

  [Invited]

  Introduction scientific journal


• 【メンブレントラフィックの奔流 分子から細胞、そして個体へ】 メンブレントラフィックと高次機能 メンブレントラフィックと神経系 軸索形成における小胞輸送の役割

  Yamamoto Yasunori, Sakisaka Toshiaki

  Lead, Dec. 2008, 蛋白質・核酸・酵素, 53巻, 16号, pp. 2207-2213, Japanese, Domestic magazine

  [Invited]

  Introduction scientific journal


• 【神経回路の制御と脳機能発現のメカニズム 細胞移動・接着から記憶・学習・行動発現までの分子基盤解明と研究を躍進させる最新技術】 分子レベルからみた回路形成 細胞接着分子によるシナプス形成機構

  Takao Kurooka, Yamamoto Yasunori, Toshiaki Sakisaka

  Jul. 2008, 実験医学, 26巻, 12号, pp. 1859-1868, Japanese, Domestic magazine

  [Invited]

  Introduction scientific journal

• 膜タンパク質工学ハンドブック

  山本 泰憲, 匂坂 敏朗

  Contributor, 第3編 膜タンパク質 ― 農学・食品への展開. 第8章 哺乳動物における小胞体膜への尾部アンカー型膜タンパク質の挿入機構, エヌ・ティー・エス, Apr. 2020, Japanese, ISBN: 9784860435370


• メンブレントラフィック 膜・小胞による細胞内輸送ネットワーク / 神経伝達物質放出を支えるメンブレントラフィック

  Yamamoto Yasunori, Sakisaka Toshiaki

  化学同人, Jul. 2016, Japanese

  Scholarly book


• Presynaptic Terminals / Roles of tomosyn in neurotransmitter release

  Yamamoto Yasunori, Toshiaki Sakiaska

  Others, Springer, 2015, English

  Scholarly book

• TMCC3 regulates formation of the reticular network of the endoplasmic reticulum.

  Yasunori Yamamoto, Sindhu Wisesa, Toshiaki Sakisaka

  第94回 日本生化学会大会, Nov. 2021, 日本生化学会, Web開催, Domestic conference

  Oral presentation


• 小胞体の網目構造を調節する因子の多量体化機構（ポスター）

  KAJIHO HIROAKI, YAMAMOTO YASUNORI, 姜 山, SAKISAKA TOSHIAKI

  第65回日本生化学会 近畿支部例会, May 2018, Japanese, 日本生化学会, 西宮, Domestic conference

  Poster presentation


• ユビキチンリガーゼ活性による小胞体の新しい形態調節機構

  Kajiho Hiroaki, Yamamoto Yasunori, Sakisaka Toshiaki

  ConBio2017, Dec. 2017, Japanese, 日本分子生物学会、日本生化学会, 神戸, Domestic conference

  Oral presentation


• ペルオキシソーム形成因子による小胞体膜変形タンパク質reticulonの翻訳後膜挿入機構

  Yamamoto Yasunori, Sakisaka Toshiaki

  ConBio2017, Dec. 2017, Japanese, 日本分子生物学会、日本生化学会, 神戸, Domestic conference

  Poster presentation


• 小胞輸送調節タンパク質Sec22CはＣ末膜貫通領域の数により細胞内局在を制御する

  Yamamoto Yasunori, 萬木 千聖, Sakisaka Toshiaki

  第64回 日本生化学会 近畿支部例会, May 2017, Japanese, 日本生化学学会 近畿支部, 大阪, Domestic conference

  Oral presentation


• 小胞体膜タンパク質による極長鎖脂肪酸合成の制御

  Uchida Yasunori, Yamamoto Yasunori, 出来 宏晃, Sakisaka Toshiaki

  第64回 日本生化学会 近畿支部例会, May 2017, Japanese, 日本生化学学会 近畿支部, 大阪, Domestic conference

  Oral presentation


• ユビキチンリガーゼによる小胞体の形態制御機構

  Kajiho Hiroaki, 姜 山, Yamamoto Yasunori, Sakisaka Toshiaki

  第64回 日本生化学会 近畿支部例会, May 2017, Japanese, 日本生化学学会 近畿支部, 大阪, Domestic conference

  Oral presentation


• Molecular mechanisms underlying ER morphology and posttranslational insertion of membrane proteins into the ER membrane

  Yamamoto Yasunori, Sakisaka Toshiaki

  The 87th Annual Meeting of the Japanese Biochemical Society, Oct. 2014, Japanese, 日本生化学会, 京都, Domestic conference

  [Invited]

  Nominated symposium


• Identification and Characterization of TMEM33 as a Reticulon-binding Protein

  張 霞, Yamamoto Yasunori, 浦出 剛史, Sakisaka Toshiaki

  The 36th Annual Meeting of The Molecular Biology Society of Japan, Dec. 2013, Japanese, The Molecular Biology Society of Japan, 神戸, Domestic conference

  Poster presentation


• 高等真核細胞おける尾部アンカー型膜タンパク質の小胞体膜挿入装置の発見

  Yamamoto Yasunori, Sakisaka Toshiaki

  The 85th Annual Meeting of the Japanese Biochemical Society, Dec. 2012, Japanese, The Japanese Biochemical Society, 福岡, Domestic conference

  Oral presentation


• Involvement of p38, an ER-localized membrane protein, in insertion of tail-anchored proteins into the ER membrane

  Yamamoto Yasunori, Sakisaka Toshiaki

  第84回日本生化学会大会, Sep. 2011, Japanese, 日本生化学会, 京都, Domestic conference

  Oral presentation


• Positive and negative roles of tomosyn in synaptic vesicle exocytosis.

  Yamamoto Yasunori, 藤倉 航平, 阪上 海央, 置村 健二郎, 小林 雄太, 中村 俊宏, Sakisaka Toshiaki

  BMB2010, Dec. 2010, Japanese, 日本分子生物学会・日本生化学会, 神戸, Domestic conference

  Oral presentation


• Involvement of RA-RhoGAP in dendritic spine formation

  黒岡 貴生, Yamamoto Yasunori, Sakisaka Toshiaki

  第32回日本分子生物学会, Dec. 2009, Japanese, 日本分子生物学会, 横浜, Domestic conference

  Poster presentation


• Reciprocal intramolecular interactions of tomosyn regulate neurotransmitter release

  Yamamoto Yasunori, 持田 澄子, 黒岡 貴生, Sakisaka Toshiaki

  第82回日本生化学会, Oct. 2009, Japanese, 日本生化学会, 神戸, Domestic conference

  Poster presentation

• 分単位の迅速な小胞体リモデリングの分子基盤と生理的意義の解明

  山本 泰憲

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, Apr. 2024 - Mar. 2027, Principal investigator


• Study on molecular mechanisms of the interplay between endoplasmic reticulum dynamics and metabolic reprogramming

  Yasunori Yamamoto

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, Apr. 2021 - Mar. 2024, Principal investigator


• 膜変形タンパク質のプロテオスタシスを基軸とする小胞体の恒常性維持機構の解明

  山本 泰憲

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• 素過程の統合的理解に基づく小胞体ネットワーク形成の全容解明

  匂坂 敏朗

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2016 - Mar. 2019

  Competitive research funding


• 翻訳の速度論的制約に立脚した全く新しい小胞体膜挿入機構の解明

  山本 泰憲

  学術研究助成基金助成金／基盤研究(C), Apr. 2015 - Mar. 2018, Principal investigator

  Competitive research funding


• SNAREタンパク質の品質管理、膜挿入、膜融合の統合的理解

  匂坂 敏朗

  科学研究費一部基金／基盤研究(B)特設, Apr. 2013 - Mar. 2018

  Competitive research funding


• 神経伝達物質放出におけるin situ可視化無細胞アッセイ系の開発

  匂坂 敏朗

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2013 - Mar. 2016

  Competitive research funding


• 尾部アンカー型膜タンパク質の小胞体への配向性膜挿入と膜構造制御に関する研究

  山本 泰憲

  科学研究費補助金／基盤研究(C), Apr. 2012 - Mar. 2015, Principal investigator

  Competitive research funding


• 神経伝達物質放出における超高速小胞融合プロセス制御

  山本 泰憲

  科学研究費補助金／新学術領域研究, 2011, Principal investigator

  Competitive research funding


• てんかんにおける神経伝達物質放出機構の素過程の異常の解明

  山本 泰憲

  科学研究費補助金／新学術領域研究, 2009, Principal investigator

  Competitive research funding


• シグナルソームによる神経軸索の伸長機構

  匂坂 敏朗

  科学研究費補助金／特定領域研究, 2008

  Competitive research funding