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KIMOTO Akira
University Hospital / Oral & Maxillofacial Surgery
Associate Professor

Researcher basic information

■ Research Areas
  • Life sciences / Surgical dentistry

Research activity information

■ Award
  • Oct. 2013 日本口腔外科学会, ゴールドリボン賞, 学会での発表
    Kimoto Akira
    Japan society

■ Paper
  • Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi
    OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.
    Dec. 2024, Oral diseases, English, International magazine
    Scientific journal

  • ヒト下歯槽神経のバリア制御に関連する分子の解析
    平岡 佑二郎, 松村 恵実, 筧 康正, 武田 大介, 重岡 学, 木本 明, 長谷川 巧実, 明石 昌也
    (NPO)日本口腔科学会, Sep. 2024, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, Japanese

  • 当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例
    高木 ひかる, 筧 康正, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也
    (公社)日本顎顔面インプラント学会, Nov. 2023, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, Japanese

  • Junya Yamashita, Akira Kimoto, Shun Teraoka, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Manabu Shigeoka, Takumi Hasegawa, Masaya Akashi
    OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.
    Oct. 2023, Oral diseases, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akira Kimoto, Junya Yamashita, Hiroaki Ohori, Noriyuki Negi, Toshinori Sekitani, Hiroki Komori, Atsushi Shioyasono, Chizu Tateishi, Takumi Hasegawa, Masaya Akashi
    OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.
    Jul. 2023, The Journal of craniofacial surgery, English, International magazine
    Scientific journal

  • 経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果
    廣田 純也, 長谷川 巧実, 伊賀 利香, 八谷 奈苗, 黒澤 泉, 武田 大介, 筧 康正, 木本 明, 明石 昌也
    (NPO)日本口腔科学会, Jul. 2023, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, Japanese

  • Yujiro Hiraoka, Megumi Matsumura, Yasumasa Kakei, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Masaya Akashi
    Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.
    Jun. 2023, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yumi Kitahiro, Takeshi Ioroi, Yasumasa Kakei, Junya Yamashita, Akira Kimoto, Takumi Hasegawa, Asami Morioka, Kazuhiro Yamamoto, Masaya Akashi, Ikuko Yano
    Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.
    MDPI AG, Jan. 2023, Methods and Protocols, 6(1) (1), 7 - 7
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究
    早瀬 悠夏, 長谷川 巧実, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 筧 康正, 木本 明, 明石 昌也
    (公社)日本顎顔面インプラント学会, Nov. 2022, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, Japanese

  • 口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例
    重永 一輝, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也
    (公社)日本顎顔面インプラント学会, Nov. 2021, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, Japanese

  • Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi
    Purpose Recurrence in oral squamous cell carcinoma (OSCC) is not rare. Due to lack of studies assessing characteristics of recurrent OSCC, including time to recurrence and outcomes, we sought to investigate its characteristics, time to recurrence, and outcomes in Japanese OSCC patients. Methods This study was a nonrandomized retrospective cohort study in a tertiary referral centre. It included 208 (117 men and 91 women) patients with recurrent oral cancer who underwent major curative surgery in the Department of Oral and Maxillofacial Surgery at Kobe University Hospital between January 1999 and April 2017. The outcomes were disease-specific survival (DSS) and overall survival (OS). Results In multivariable Cox proportional hazards analysis, the time to recurrence (hazard ratio [HR] 3.55, 95% confidence interval [CI] 1.69-6.63; P = 0.001), extranodal extension (ENE, HR 2.72, 95% CI 1.51-4.89; P = 0.001), and high T stage (HR 2.00, 95% CI 1.01-3.97; P = 0.046) were independent predictors of DSS. The time to recurrence (HR 3.29, 95% CI 1.82-5.96; P < 0.001) and ENE (HR 2.64, 95% CI 1.52-4.56; P = 0.001) were independent predictors of OS. Conclusion Time to recurrence, extranodal extension, and higher T stage were independent prognosis predictors in OSCC.
    SPRINGER INDIA, Feb. 2021, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 舌下神経麻痺を契機に発見された前立腺癌脳転移の1例
    佐々木 亜紀, 木本 明, 八谷 奈苗, 村上 明希, 明石 昌也
    (NPO)日本口腔科学会, Sep. 2020, 日本口腔科学会雑誌, 69(3) (3), 245 - 245, Japanese

  • 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討
    廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也
    (NPO)日本口腔科学会, Jul. 2020, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, Japanese

  • Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi
    BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.
    Jun. 2020, BMC cancer, 20(1) (1), 568 - 568, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi
    PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.
    May 2020, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 佐々木 崇良, 木本 明, 八谷 奈苗, 山下 淳也, 重岡 学, 明石 昌也
    (一社)日本レーザー歯学会, May 2020, 日本レーザー歯学会誌, 30(1) (1), 22 - 22, Japanese

  • 【「歯科用レーザーの現在」】軟組織に対する歯科用レーザーの活用
    木本 明, 明石 昌也, 古森 孝英
    (一社)日本歯科理工学会, Sep. 2019, 日本歯科理工学会誌, 38(3) (3), 149 - 152, Japanese

  • 木本 明, 明石 昌也
    (NPO)日本レーザー医学会, Sep. 2019, 日本レーザー医学会誌, 40(3) (3), 265 - 265, Japanese

  • Exploring a Novel Screening Method for Patients with Oral Squamous Cell Carcinoma: A plasma Metabolomics Analysis.
    Yui Enomoto, Akira Kimoto, Hiroaki Suzuki, Shin Nishiumi, Masaru Yoshida, Takahide Komori
    AIM: This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC). PATIENTS & METHODS: We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates. RESULTS: We selected four biomarker candidates against OSCC. Their sensitivity was more than 90%, and the AUC was over 0.9 according to the receiver operating characteristic curve analysis. CONCLUSIONS: The findings of this study suggest four potential metabolites as biomarkers for OSCC screening.
    Sep. 2018, The Kobe journal of medical sciences, 64(1) (1), E26-E35 - E35, English, Domestic magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Michinori Maeda, Marina Hirose, Keinoshin Wada, Megumi Kishimoto, Masaya Akashi, Akira Kimoto, Takahide Komori, Yasuyuki Shibuya
    The aim of this study was to clarify the masticatory function and oral health-related quality of life (OHRQoL) for different ranges of mandibulectomy and also continuity resection of the mandible. A total of thirty one patients who underwent mandibulectomy and were classified into AT, body, and marginal resection (MR) groups according to the CAT classification were investigated. The masticatory function was evaluated using a color-changing gum, a gummy jelly, and a modified Sato's questionnaire. The OHRQoL was evaluated using the Oral Health Impact Profile (OHIP), which included seven subscales. There were significant differences between the AT group and body group in the findings from the color-changing gum and the OHIP (P < 0.05). There was also a significant difference between the AT group and body group regarding the degree of physical disability and psychological disability (subscales of the OHIP) (P < 0.05). There were no significant differences between the body and MR group in any of the tests. Consequently, the body group showed a higher masticatory function and OHRQoL than the AT group despite having the same category of mandibulectomy defect however, the masticatory function and OHRQoL in the body and MR groups were found to be closely similar, at least, regarding the chewing performance.
    Elsevier Ltd, May 2018, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 30(3) (3), 220 - 224, English
    [Refereed]
    Scientific journal

  • 金属アレルギーを伴う骨格性下顎前突患者に対し外科的矯正治療を行った1例
    塩屋園 敦, 立石 千鶴, 長谷川 巧実, 木本 明, 鈴木 泰明, 古土井 春吾, 古森 孝英, 神戸大学医学部附属病院歯科口腔外科矯正歯科診療班
    (NPO)日本顎変形症学会, May 2018, 日本顎変形症学会雑誌, 28(2) (2), 181 - 181, Japanese
    [Refereed]

  • Kawase-KogaY, ShibataK, Kimoto Akira, WatanabeM, ChikazuD
    Sagittal split ramus osteotomy and intraoral vertical ramus osteotomy are commonly performed for the correction of jaw deformities. However, during mandibular orthognathic surgeries such as sagittal split ramus osteotomy and intraoral vertical ramus osteotomy , the authors sometimes encounter exposure of the buccal fat pad (BFP), which decreases the surgical field. The exposed BFP makes it difficult to perform these operations, may result in unexpected complications, and may increase the operation time. Therefore, the authors herein describe a simple, safe, and convenient technique for reducing the volume of the exposed BFP during mandibular orthognathic surgery using an electric knife in the coagulation mode.
    Feb. 2018, J Craniofac Surg, 29(4) (4), e404-e405, English, International magazine
    [Refereed]
    Scientific journal

  • Kawase-KogaY, FujiiY, IkehataM, IkehataN, KonoM, Kimoto Akira, WatanabeM, ChikazuD
    The aim of this study was to evaluate the effects of early removal of fixed plates in patients with occlusal discrepancies after sagittal split ramus osteotomy (SSRO) with a focus on the positional relationship of the temporomandibular joint (TMJ). Sagittal split ramus osteotomy with/without Le Fort I osteotomy was performed on 98 patients with mandibular prognathism. Of these 98 patients, 15 with occlusal discrepancies and/or TMJ symptoms underwent early plate removal after SSRO. Finally, 12 consecutive patients were evaluated in this study: 7 underwent bilateral SSRO, 1 underwent unilateral SSRO, and 4 underwent bilateral SSRO with maxillary advancement. The axiolateral TMJ Schuller method was used to evaluate the TMJ position. The authors measured 3 spaces (anterior, superior, and posterior joint spaces) between the condyle and glenoid fossa in the sagittal plane. The anterior and superior joint spaces were significantly larger immediately after the operation than before the operation. After early plate removal, these spaces significantly decreased in size. The posterior joint space increased, but with no significant difference. Three months after SSRO, the size of each of the 3 spaces was closely related to its preoperative size. In conclusion, these results suggest that early removal of fixed plates is 1 treatment option for postoperative occlusal discrepancies after SSRO.
    Jan. 2018, J Craniofac Surg, 29(4) (4), 900 - 903, English, International magazine
    [Refereed]
    Scientific journal

  • Akira Kimoto, Hiroaki Suzuki, Junya Yamashita, Junichiro Takeuchi, Kousuke Matsumoto, Yui Enomoto, Takahide Komori
    Objective: The purpose of this study was to retrospectively evaluate the postoperative results of partial glossectomy for early tongue cancer using a carbon dioxide laser (CO2 laser). Background data: CO2 lasers are frequently used for the excision or treatment of soft tissue in a range of diseases, including oral cancer, leukoplakia, mucocele, anomalies of the labial and lingual frenum, and peri-implantitis. Materials and methods: We retrospectively reviewed 31 primary cases of early superficial tongue cancer that were treated using CO2 lasers. In this study, early superficial cancer of the tongue is defined as a T1 or T2 tumor (TNM classification, NOMO; type, superficial spread, or exophytic; depth, <5 mm). The lesions were stained with 10% Lugol's solution and excised with a 5-or 10-mm safety margin from the nonstained area or induration using a CO2 laser. The raw surface was covered with a polyglycolic acid sheet using fibrin glue spray (n = 23), sutures (n = 6), or both (n = 2). Five of the patients showed a bleeding tendency: 1 was taking warfarin 100 mg per day, 1 was taking 350 mg per day, 2 were taking aspirin 100 mg per day, and 1 was taking aspirin 200 mg per day. Results: There were no cases of postoperative bleeding. Regarding postoperative pain, all patients could stop taking analgesic drugs by 1 month after undergoing the operation. In regards to postoperative difficulty to swallow, all could start swallowing rice gruel 2 days after the operation. The surgical margin was unclear in two cases due to the thermal denaturation of the excisional margin. The 2-year local control rate was 100% and subsequent cervical lymph node metastasis rate was 6.5%. Conclusions: In terms of recurrence, metastasis, postoperative bleeding, postoperative pain, and swallowing, partial glossectomy for early tongue cancer using a CO2 laser might therefore help improve the postoperative course.
    MARY ANN LIEBERT, INC, Sep. 2017, PHOTOMEDICINE AND LASER SURGERY, 35(9) (9), 479 - 483, English
    [Refereed]
    Scientific journal

  • Postradiotherapy Dental Implant Insertion Into Bone Grafts Harvested From Nonirradiated Tissue: Case Reports
    Kimoto Akira, ShibuyaY, KobayashiM, AkashiM, HasegawaT, SuzukiH, Komori Takahide
    Oct. 2016, Implant Dent, 25(5) (5), 715 - 9, English
    [Refereed]
    Scientific journal

  • Yui Enomoto, Hiroaki Suzuki, Akira Kimoto, Tomoko Asai, Junichiro Takeuchi, Kousuke Matsumoto, Takahide Komori
    Objective In this study, we investigated the degree of concordance in the histopathological diagnosis among lesions clinically diagnosed with oral lichen planus (OLP) to understand the importance of the histopathological examination. Methods In total, 169 patients clinically diagnosed with OLP on their initial visit to our hospital between 2001 and 2012 were experienced. Of them, histopathological examinations were carried out for 77 patients (83 lesions), and they were selected as the subjects of this study. The age, gender, location of the lesion, clinical type of OLP determined via visual inspection, and histopathological findings were investigated. Results Of the 77 patients, 12 were male and 65 were female, with a mean age of 63.9 years. Histopathological examinations were performed in 83 lesions, of which 54 were diagnosed as OLP. Among the diagnostically discordant 29 lesions, most were histopathologically diagnosed as leukoplakia (15 lesions, 51.7%), whereas one was diagnosed as squamous cell carcinoma (3.4%). The most frequent location of discordant lesions was the tongue (discordant rate: 77.8%), and the most clinical type was plaque (discordant rate: 90.0%) all of which were atypical types of OLP. Conclusions The rate of discordance between the clinical and histopathological diagnoses was 34.9%. These results indicate that histopathological examinations are essential for obtaining the differential diagnosis to distinguish the lesion from other diseases with a clinical presentation similar to that of OLP.
    Elsevier Ltd, Sep. 2016, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 28(5) (5), 381 - 384, English
    [Refereed]
    Scientific journal

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状
    平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, Jul. 2016, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, Japanese

  • Komori Takahide, 榎本由依, 北山美登里, 小守紗也華, 松本耕祐, 木本明, 竹内純一郎, Suzuki Yasuaki

    Lasers are widely used in the oral and maxillofacial region surgeries. The CO2 laser has been used in the treatment of diseases that occur in soft tissue because of its excellent incision and hemostatic abilities, and good results have been obtained. The Nd:YAG and KTP lasers have an affinity for pigmented tissues and penetrate soft tissues deeply. Using these characteristics, vascular malformations (hemangiomas) can be treated by photocoagulation with these lasers. In this paper, current status of oral and maxillofacial laser surgery is reported with some case presentations.

    Japan Society for Laser Surgery and Medicine, Apr. 2016, 日本レーザー医学会誌, 37(1号) (1号), 52 - 57, Japanese
    [Refereed]
    Scientific journal

  • 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究
    松本耕祐, 榎本由依, 小野真嵩, 小守紗也華, 北山美登里, Kimoto Akira, Suzuki Yasuaki, Komori Takahide
    Dec. 2015, 日本レーザー歯学会誌, 26(3号) (3号), 124 - 129, Japanese
    [Refereed]
    Scientific journal

  • 口腔白板症の臨床診断と病理組織診断の一致性についての検討 安全な口腔白板症のレーザー治療の実現に向けて
    榎本由依, Suzuki Yasuaki, 重岡學, 北山美登里, 松本耕祐, Kimoto Akira, 竹内純一郎, Komori Takahide
    Dec. 2015, 日本レーザー歯学会誌, 26(3号) (3号), 120 - 123, Japanese
    [Refereed]
    Scientific journal

  • 口腔白板症の臨床診断と病理組織診断の一致性についての検討 -安全な口腔白板症のレーザー治療の実現に向けて-
    榎本由依, SUZUKI HIROAKI, 浅井知子, SHIGEOKA MANABU, 北山美登里, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE
    Dec. 2015, 日本レーザー歯学会誌, 26(3) (3), 120 - 3, Japanese
    [Refereed]
    Scientific journal

  • 下顎臼歯部歯槽堤の頬側傾斜形態を考慮してサンドウィッチグラフトを応用した1例
    山下淳也, Kimoto Akira, Suzuki Yasuaki, Komori Takahide
    Nov. 2015, Japanese Journal of Maxillo Facial Implants, 14(3号) (3号), 193, Japanese
    Research society

  • CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible
    Akashi Masaya, ShibuyaY, WanifuchiS, KusumotoJ, SakakibaraA, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Hashikawa Kazunobu, Komori Takahide
    Oct. 2015, Implant Dent, 24(5) (5), 541 - 6, English
    [Refereed]
    Scientific journal

  • 大理石骨病患者に対し矯正治療を行った1例
    北山美登里, 岡本奈那, 西村玲美, Kimoto Akira, Komori Takahide
    Sep. 2015, 障害者歯科, 36(3号) (3号), 423, Japanese
    Research society

  • 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究(会議録)
    小野真嵩, 松本耕祐, 山下淳也, 小守紗也華, 榎本由依, 北山美登里, Kimoto Akira, Suzuki Yasuaki, Komori Takahide
    Aug. 2015, 日本レーザー歯学会誌, 26(2号) (2号), 90, Japanese
    Research society

  • CO2レーザーによる舌早期癌に対する舌部分切除術に関する検討
    山下淳也, Kimoto Akira, 榎本由依, 松本耕祐, 小野真嵩, 筧康正, Suzuki Yasuaki, Komori Takahide
    (一社)日本レーザー歯学会, Aug. 2015, 日本レーザー歯学会誌, 26(2) (2), 89 - 90, Japanese
    Research society

  • Kousuke Matsumoto, Hiroaki Suzuki, Tomoko Asai, Reina Wakabayashi, Yui Enomoto, Midori Kitayama, Manabu Shigeoka, Akira Kimoto, Junichiro Takeuchi, Hirokazu Yutori, Takahide Komori
    Objective: Previous studies have described the clinical statistics and treatment outcomes of leukoplakia of the oral cavity. However, because leukoplakia is often clinically diagnosed without any histopathological examination, current opinion regarding treatment methods and preoperative pathological diagnosis is inconsistent and no standard site-specific treatment guidelines exist for oral leukoplakia. The purpose of this study is to clinically evaluate carbon dioxide (CO< inf> 2< /inf> ) laser treatment for leukoplakia of the tongue. Methods: We examined 38 lesions in 35 patients of lingual leukoplakia who underwent CO< inf> 2< /inf> laser treatment with using Lugol staining at our department over a 10-year period, i.e., from 2001 to 2010. We investigated gender-related differences, age distribution, left and right differences, clinical classification, histopathological diagnosis (presence or absence of epithelial dysplasia), treatment technique (excision or evaporation), recurrence rate, residual rate, and malignant transformation among these cases. Results: Of the 38 lesions that fulfilled the inclusion requirements, 35 were excised and 3 were evaporated. After CO< inf> 2< /inf> laser treatment, the recurrence and residual rates for lingual leukoplakia were 10.5% and 7.9%, respectively. The recurrence rate of cases examined in this study was lower than that reported by our hospital previously (2004) and many other hospitals. None of the lesions exhibited malignant transformation. Conclusions: Our results suggest that the CO< inf> 2< /inf> laser excision method with using Lugol staining, as performed at our hospital, is useful for the treatment of lingual leukoplakia.
    Elsevier Ltd, Jul. 2015, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27(4) (4), 493 - 497, English
    [Refereed]
    Scientific journal

  • Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia
    Matsumoto K, SUZUKI HIROAKI, Asai T, Wakabayashi R, Enomoto Y, Kitayama M, SHIGEOKA MANABU, KIMOTO AKIRA, Takeuchi J, Yutori H, KOMORI TAKAHIDE
    Jul. 2015, J Oral Maxillofac Surg Med Pathol, 44(7) (7), 929 - 35, English
    [Refereed]
    Scientific journal

  • 口腔白板症の臨床診断と病理組織診断の一致性および治療法についての検討
    榎本由依, Suzuki Yasuaki, 北山美登里, 重岡学, 松本耕祐, Kimoto Akira, 浅井知子, 竹内純一郎, Komori Takahide
    Apr. 2015, 日本レーザー歯学会誌, 26(1号) (1号), 56, Japanese
    Research society

  • Clinical study of 19 cases resulting in dental implant removal
    Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori
    Dental implant treatment is a highly anticipated therapy with widespread use. However, various accidental symptoms and complications have been reported, and we may reluctantly have to remove an implant body out of necessity. This study evaluated 19 cases (21 jaws) that resulted in removal after the enforcement of implant treatment in our hospital from January 2003 to August 2013 and clarified the details of the removals clinically for the purpose of improvement of future treatment results. Implants were removed at a higher frequency in elderly patients, particularly those 70 years of age or older. The removal rate regarding the tooth missing style was high in edentulous jaw cases in both the maxilla and mandible, and was low in defective cases of middle teeth. Regarding the duration and cause of removal, approximately half of the implants were removed due to defective primary stability within 6 months for periods greater than 6 months, all cases except 1 jaw were removed within 30 months and many cases were due to peri-implantitis. Preoperation evaluations, primary stability of the implant body at the time of the operation, long-term observation and maintenance, and patient education are crucial to reduce the frequency of removal.
    Kobe University School of Medicine, 2015, Kobe Journal of Medical Sciences, 61(4) (4), E102 - E108, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia
    MatsumotoK, Suzuki Yasuaki, AsaiT, WakabayashiR, EnomotoY, KitayamaM, ShigeokaM, Kimoto Akira, TakeuchiJ, YutoriH, Komori Takahide
    2015, Int J Oral Maxillofac Surg, 44(7) (7), 929 - 935, English
    [Refereed]
    Scientific journal

  • 電気メス、レーザー等を用いた手術に関連するインシデントについて
    Suzuki Yasuaki, 筧 康正, 安岡 大介, 榎本 由依, 北山 美登里, Kimoto Akira, 松本 耕祐, 浅井 知子, 村田 真穂, Komori Takahide
    日本医療機能評価機構による医療事故情報収集等事業第1〜37回報告書(平成17年4月〜平成26年3月)から狩猟し得た「電気メス・レーザー等を使用した手術に関連するインシデント事例」86件を対象に、使用された医療機器の内訳、患者への影響、原因について調査した。結果、使用された医療機器は、「電気メス」61件(71%)、「サージビームや消化管内視鏡などの光源」11件(13%)、「ラジオ波焼灼治療機器」7件(8%)、「レーザー」5件(6%)、「超音波凝固切開装置」2件(2%)であった。患者への影響は、「熱傷」46件(53%)、「異物残存」8件(9%)、「近接組織(臓器)の損傷」6件(7%)、「穿孔」3件(3%)、「その他」5件(6%)、「影響なし」18件(21%)であった。原因は、「使用方法の誤り」33件(38%)、「機器の不具合・破損」20件(23%)、「突然の発火」17件(20%)、「対極板の使用に関連したもの」9件(10%)、「その他」7件(8%)であった。患者への影響・原因のうち比較的多くみられた以下のケースについて改善策を中心に考察した。1)発火(薬剤等の併用による発火、ガーゼや綿球への引火、挿管チューブへの引火)。2)機器の置き場に関連する熱傷。3)機器の不具合・破損(機器の劣化が原因のもの)。
    (一社)日本レーザー歯学会, Dec. 2014, 日本レーザー歯学会誌, 25(3) (3), 136 - 139, Japanese
    [Refereed]
    Scientific journal

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例
    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英
    (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, Japanese

  • 当科におけるインプラント242例907本埋入に関する臨床的検討
    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, Japanese

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, Nov. 2014, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, Japanese

  • 高田 直樹, Shibuya Yasuyuki, Hasegawa Takumi, Kimoto Akira, 鈴木 泰明, Komori Takahide
    Cystadenocarcinoma is an uncommon salivary gland tumor that occurs in the palate. We report a rare case of cystadenocarcinoma arising in the palate. A 80-year-old man visited a certain hospital because of a painless swelling in the palate. A biopsy was performed, and adenocarcinoma was diagnosed histopathologically. He was therefore referred to our hospital to receive treatment for adenocarcinoma. He had a painless swelling, measuring 25 × 15 mm, in the left side of the palate. Computed tomography showed no evidence of cervical metastasis. Partial maxillectomy was performed, and the final histopathological diagnosis was cystadenocarcinoma. There was no evidence of recurrence or metastasis 20 months after the operation.
    Japanese Society of Oral and Maxillofacial Surgeons, Oct. 2014, 日本口腔外科学会雑誌, 60(10号) (10号), 561 - 565, Japanese
    [Refereed]
    Scientific journal

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性
    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英
    (NPO)日本口腔科学会, Sep. 2014, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, Japanese

  • レーザー治療後の経過観察中に悪性化を認めた口腔白板症3例の検討
    榎本由依, SUZUKI HIROAKI, 浅井知子, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE
    Apr. 2014, 日本レーザー歯学会誌, 25(1) (1), 8 - 13, Japanese
    [Refereed]
    Scientific journal

  • Clinical study of implant treatment for diabetic patients
    Enomoto Y, Suzuki Yasuaki, Kakei Y, Matsumoto K, Kimoto Akira, Komori Takahide
    2014, Oral Science in Japan, 49 - 50, English
    [Refereed]
    Scientific journal

  • The long-term effects of red light-emitting diode irradiation on the proliferation and differentiation of osteoblast-like MC3T3-E1 cells
    Tomoko Asai, Hiroaki Suzuki, Midori Kitayama, Kousuke Matsumoto, Akira Kimoto, Manabu Shigeoka, Takahide Komori
    Low level laser therapy (LLLT) affects various biological processes, and it is said that the non-coherent light of the light-emitting diode (LED) has a similar action. The purpose of this study was to examine the effects of LED light on the proliferation and differentiation of osteoblasts-like MC3T3-E1 cells cultured in osteogenic differentiation medium (ODM) over the long term. Cells were irradiated with red LED light of 630 nm at three doses 0.5J/cm2, 1.5J/cm2 or 3.0J/cm2 for the cell proliferation activity assay, and at 0.5J/cm2 for the osteogenic differentiation activity assay. The former activity was checked by counting the number of viable cells using Trypan blue dye. The latter activity was evaluated by alkaline phosphatase (ALP) staining and examining the mRNA expression of the osteopontin (OPN) gene using real-time quantitative PCR. The number of viable MC3T3-E1 cells showed a tendency to increase after the irradiation at all three energy densities in comparison with a non-irradiation group (control group). In particular, there was a remarkable 3.34-fold increase in the group irradiated with 3.0J/cm2 on day 7 after starting the culture. On culture day 15, there was a tendency for the red LED irradiation group (0.5 J/cm2) to exhibit more staining for ALP than the control group, and the expression of OPN was significantly higher in the irradiation group on culture day 16. In conclusion, low level red LED light can enhance MC3T3-E1 cell proliferation and osteogenic differentiation when the cells are cultured for a relatively long time.
    Kobe University School of Medicine, 2014, Kobe Journal of Medical Sciences, 60(1) (1), E12 - E18, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 木本 明, 渋谷 恭之, 浅野 真衣, 高田 直樹, 竹内 佑香, Komori Takahide
    Leiomyoma is a benign tumor of smooth muscle origin, and usually arises in the uterus, alimentary tract, and skin. Since the first report by Blanc in 1884, most reported leiomyomas have been angioleiomyomas. In the present report, we describe a rare type of leiomyoma arising in the tongue of a 25-year-old woman. The tumor was an 18 × 7 mm, well-demarcated, and slow growing mass located in the right margin of the tongue. The entire lesion was excised, and the pathological diagnosis was solid leiomyoma. The patient has been followed up for 1 year 2 months after surgery, without any evidence of recurrence.
    Japanese Society of Oral and Maxillofacial Surgeons, Aug. 2013, 日本口腔外科学会雑誌, 59(8号) (8号), 522 - 526, Japanese
    [Refereed]
    Scientific journal

  • 木本 明, 鈴木 泰明, Furudoi Shungo, Takeuchi Junichi, 浅井 知子, Komori Takahide
    Abstract: Patients with rheumatoid arthritis often receive methotrexate (MTX). Recently, it has been shown that MTX can cause B cell lymphoma, non-Hodgkins lymphoma. B cell lymphoma caused by MTX is referred to as a methotrexate-associated lymphoproliferative disorder (MTX-LPD) and is recognized by the World Health Organization and included among immunodeficiency-associated LPD. We describe a rare case of MTX-LPD with osteonecrosis of the jaw of maxilla and mandible in which spontaneous complete remission was achieved.
    Japanese Society of Oral and Maxillofacial Surgeons, Mar. 2013, 日本口腔外科学会雑誌, 59(3号) (3号), 197 - 201, Japanese
    [Refereed]
    Scientific journal

  • 浅井 知子, 南川 勉, 木本 明, 鈴木 泰明, 渋谷 恭之, Komori Takahide
    A case of Ewings sarcoma of the mandible in a young child is presented. A 12-year-old boy was referred to our hospital because of swelling of the cheek, which he noticed 2 months previously. Clinical examination revealed diffuse swelling of the cheek, and a fistula of the gingiva. CT examination revealed a sun-ray apiculated image. MR showed a contract-enhancing lesion in the left mandibular angle. FDG-PET and Ga-scintigraphy revealed no metastasis. Based on the results of histopathological analysis, Ewings sarcoma was diagnosed. The patient received combined chemotherapy, surgery, and radiotherapy. The patient has shown no evidence of recurrence or metastasis for 24 months.
    Japanese Society of Oral and Maxillofacial Surgeons, Feb. 2013, 日本口腔外科学会雑誌, 59(2号) (2号), 88 - 92, Japanese
    [Refereed]
    Scientific journal

  • A novel gas chromatography mass spectrometry-based serum screening method for Oral squamous cell carcinoma
    Kimoto, A., Nishiumi, S., Kobayashi, T., Terashima, Y., Suzuki, H., Takeuchi, J., Azuma, T., Komori, T., Yoshida, M.
    2013, Head and Neck Oncology, 5(4) (4), 40, English
    [Refereed]
    Scientific journal

  • Fumi Kawakami, Takanori Hirose, Akira Kimoto, Takahide Komori, Tomoo Itoh
    We describe a plexiform perineurioma, which is an extremely rare variant of soft tissue perineurioma. A 43-year-old Japanese man presented with a painless, well-demarcated, elastic, soft tumor measuring 2.0 × 1.9 cm on the upper lip that had persisted for three years. Microscopically, a plexiform tumor composed of minimally atypical spindle cells with wavy nuclei was located in the lamina propria of the oral mucosa. Tumor cells were concentrically arranged around small vessels and aligned in parallel with delicate collagen fibers on a fibromyxoid background in the hypocellular area. Tumor cells were immunohistochemically positive for EMA, GLUT-1, claudin-1, and CD34 and negative for S-100 protein. The histopathological and immunohistochemical profiles of the excised tumor indicated a diagnosis of plexiform perineurioma. The patient has remained free of recurrence for sixteen months. Intraoral soft tissue perineurioma is rare and two of the four reported plexiform perineuriomas, including that described herein, notably involved the intraoral area. According to previous reports, plexiform perineuriomas largely develop in middle-aged women without a history of type 1 or type 2 neurofibromatosis. The clinical courses of all reported plexiform perineuriomas have been benign.
    Oct. 2012, Pathology international, 62(10) (10), 704 - 8, English, International magazine
    [Refereed]
    Scientific journal

  • 今井 佑輔, 南川 勉, 木本 明, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, Jan. 2012, 日本口腔科学会雑誌, 61(1) (1), 128 - 129, Japanese

  • TAKEUCHI Junichiro, UMEDA Masahiro, MURATA Maho, KAKEI Yasumasa, KIMOTO Akira, SUZUKI Hiroaki, SHIGETA Takashi, RI Shinsho, KOMORI Takahide
    白板症や早期舌癌で舌部分切除術が行われた68例(男性35例、女性33例、平均61.7歳)を対象に、術後開放創にコラーゲン使用人工皮膚貼付の31例(コラーゲン群)と、フィブリン糊でポリグリコール酸(PGA)シート貼付の37例(PGA群)に分け、その効果について比較した。病理診断は異型上皮・上皮内癌28例、扁平上皮癌40例、平均切除面積はコラーゲン群:837.3mm2、PGA群:736.0mm2、術後鎮痛剤服用平均日数はコラーゲン群:7.2日、PGA群:5.9日であり、PGAシート付着最終確認日は平均15.4日であった。コラーゲン群とPGA群の瘢痕拘縮の程度は、「なし」がそれぞれ5例、13例、「軽度」が16例、23例、「中等度」が10例、1例、「高度」は両群とも0例であった。なお、術後の栄養摂取はコラーゲン群が1週間、PGA群が2日間経鼻チューブを使用した。舌部分切除後のフィブリン糊とPGAシート使用は早期摂食、疼痛緩和、瘢痕拘縮予防に有用と考えられた。
    日本口腔外科学会, Jul. 2011, Japanese journal of oral and maxillofacial surgery, 57(7) (7), 394 - 400, Japanese

  • 竹内 純一郎, 鈴木 泰明, 木本 明, 松本 耕祐, 村田 真穂, 古森 孝英
    (一社)日本レーザー歯学会, Apr. 2010, 日本レーザー歯学会誌, 21(1) (1), 45 - 45, Japanese

  • 重岡 学, 鈴木 泰明, 梶 真人, 木本 明, 服部 真季, 松本 耕祐, 村田 真穂, 古森 孝英
    (一社)日本レーザー歯学会, Aug. 2008, 日本レーザー歯学会誌, 19(2) (2), 90 - 90, Japanese

  • 外側舌リンパ節転移を認めた口底癌の1例
    木本 明, 南川 勉, 小林 正樹, 服部 真季, 明石 昌也, 澁谷 恭之, 横尾 聡, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, Jun. 2007, 日本口腔外科学会雑誌, 53(6) (6), 400 - 400, Japanese

  • 鈴木 泰明, 木本 明, 時岡 早苗, 村田 真穂, 服部 真季, 松本 耕祐, 梶 真人, 古森 孝英
    (一社)日本レーザー歯学会, Apr. 2007, 日本レーザー歯学会誌, 18(1) (1), 57 - 57, Japanese

  • 服部 真季, 鈴木 泰明, 松本 耕祐, 木本 明, 梶 真人, 村田 真穂, 尾島 泰公, 時岡 早苗, 横尾 聡, 古森 孝英
    (NPO)日本レーザー医学会, Jan. 2007, 日本レーザー医学会誌, 27(4) (4), 359 - 359, Japanese

■ MISC
  • Clinical analysis of the chronological change in bone mass following sinus floor elevation
    Suzuki Hiroaki, Matsumoto Kousuke, Enomoto Yui, Kakei Yasumasa, Kimoto Akira, Akashi Masaya, Komori Takahide
    Japanese Stomatological Society, 2015, Oral science in Japan, 79 - 82, English

  • 【全身疾患と抜歯-最新の知識による適切な対応-】 喘息・アレルギー疾患を有する患者の抜歯
    Kimoto Akira, Komori Takahide
    Jan. 2015, 歯科医療, 29(1号) (1号), 30 - 37, Japanese
    [Invited]
    Introduction commerce magazine

  • 【全身疾患と抜歯-最新の知識による適切な対応-】 全身疾患を有する患者の抜歯の際に注意すべき基本的事項
    Komori Takahide, Akashi Masaya, Suzuki Yasuaki, 榊原晶子, Kimoto Akira, Minamikawa Tsutomu, Hasegawa Takumi, Furudoi Shungo
    (株)第一歯科出版, Jan. 2015, 歯科医療, 29(1号) (1号), 4 - 10, Japanese
    [Invited]
    Introduction scientific journal

  • Successive macroglossia after toxic epidermal necrolysis
    Suzuki Yasuaki, Shibuya Y, Enomoto Y, Kimoto Akira, Matsumoto K, Kakei Y, Komori Takahide
    Japanese Stomatological Society, 2014, Oral Science in Japan, 79 - 81, English
    Introduction scientific journal

  • Clinical experience with the application of polyglycolic acid sheets and fibrin glue spray after resection of buccal mucosal lesions: A pilot study
    Kakei Y, Suzuki Yasuaki, Enomoto Y, Kimoto Akira, Matsumoto K, Takeuchi J, Komori Takahide
    Japanese Stomatological Society, 2014, Oral Science in Japan, 69 - 71, English
    Introduction scientific journal

  • A case report of dental treatment of Shy-Drager syndrome
    KIMOTO AKIRA
    30 Sep. 2011, 障害者歯科, 32(3) (3), 429 - 429, Japanese

■ Books And Other Publications
  • 全身疾患と抜歯 -最新の知識による適切な対応- / 全身疾患と抜歯 -最新の知識による適切な対応-
    古森孝英, 明石昌也, 鈴木泰明, 榊原晶子, Kimoto Akira, 南川勉, 長谷川巧, 古土井春吾
    Others, 第一歯科出版, 2015, Japanese
    Scholarly book

  • 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / アナフィラキシーへの対応
    Kimoto Akira, 高橋佑豪
    Others, 第一歯科出版, 2014, Japanese
    General book

■ Lectures, oral presentations, etc.
  • 神戸大学病院歯科口腔外科における過去10年間のレーザー治療に対する臨床的検討
    香西慎一, KIMOTO AKIRA, 八谷奈苗, 山下淳也, 松尾健司, 榎本由依, 松本耕祐, 北山美登里, SHIGEOKA MANABU, SUZUKI HIROAKI, KOMORI TAKAHIDE
    第30回記念日本レーザー歯学会学術大会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験
    鰐渕 聡, Akashi Masaya, Hashikawa Kazunobu, 筧 康正, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Minamikawa Tsutomu, Furudoi Shungo, 古森 孝英
    第60回日本口腔外科学会総会, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference
    Oral presentation

  • 下顎臼歯部頬側傾斜形態を考慮してサンドウィッチグラフト法を応用した1例
    山下 淳也, Kimoto Akira, Suzuki Yasuaki, 古森 孝英
    第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference
    Oral presentation

  • Search for oral cancer relates biomarker by metabolomics of plasma in tumor-bearing nude mice．
    榎本 由依, Kimoto Akira, 鰐渕 聡, Suzuki Yasuaki, 古森 孝英
    第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference
    Oral presentation

  • Nd：YAGレーザー光凝固療法を複数回行った口腔領域血管奇形5症例の臨床的検討
    小野 真嵩, 松本 耕祐, 山下 淳也, 小守 紗也華, 榎本 由衣, 北山 美登里, Kimoto Akira, Suzuki Yasuaki, 古森 孝英
    第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference
    Oral presentation

  • Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．
    松尾 健司, Suzuki Yasuaki, 松本 耕祐, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 順一郎, 古森 孝英
    第60回日本口腔外科学会総会．, Oct. 2015, Japanese, 日本口腔外科学会, 名古屋, Domestic conference
    Oral presentation

  • Effects of Red Light-Emitting Diode Irradiation on the Proliferation and Differentiation of Preosteoblastic MC3T3-E1 Cells
    SUZUKI HIROAKI, Asai T, Enomoto Y, Kitayama M, KIMOTO AKIRA, SHIGEOKA MANABU, Chikazu D, KOMORI TAKAHIDE
    22nd International conference on oral and maxillofacial surgery, Oct. 2015, Japanese, Mellbourne, Australia, International conference
    Poster presentation

  • "EFFECTS OF RED LIGHT-EMITTING DIODE IRRADIATION ON THE PROLIFERATION AND DIFFERENTIATION OF PREOSTEOBLASTIC MC3T3-E1 CELLS,
    Suzuki Yasuaki, Asai T, Enomoto Y, Kitayama M, Matsumoto Kensuke, Kimoto Akira, Shigeoka M, Chikazu D, Komori Takahide
    22nd International conference on oral and maxilofacial surgery,, Oct. 2015, Japanese, メルボルン, オーストラリア, International conference
    Oral presentation

  • 女児の下顎枝に生じたランゲルハンス細胞組織球症の1例
    定兼 啓倫, Kimoto Akira, 榎本 由依, 小林 正樹, Minamikawa Tsutomu, 古森 孝英
    第46回日本口腔外科学会近畿支部学術集会．, Jun. 2015, Japanese, 日本口腔外科学会, 神戸, Domestic conference
    Oral presentation

  • 口腔扁平苔癬に対する炭酸ガスレーザー蒸散療法の臨床評価に関する前向き研究
    小野 真嵩, 松本 耕祐, 山下 淳也, 小守 紗也華, 榎本 由衣, 北山 美登里, Kimoto Akira, Suzuki Yasuaki, 古森 孝英
    日本レーザー歯学会, Jun. 2015, Japanese, 日本レーザー歯学会, 北海道, Domestic conference
    Oral presentation

  • CO2レーザーによる舌早期癌に対する舌部分切除に関する検討
    山下 淳也, Kimoto Akira, 榎本 由依, 松本 耕祐, 小野 真嵩, 筧 康正, Suzuki Yasuaki, 古森 孝英
    日本レーザー歯学会, Jun. 2015, Japanese, 日本レーザー歯学会, 北海道, Domestic conference
    Oral presentation

  • 口腔白板症の臨床診断の一致性および治療法についての検討
    榎本由依, SUZUKI HIROAKI, 北山美登里, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 浅井知子, 竹内純一郎, KOMORI TAKAHIDE
    第26回日本レーザー歯学会総会・学術大会, Dec. 2014, Japanese, 東京, Domestic conference
    Poster presentation

  • 口腔白板症の臨床診断の一致性および治療法についての検討
    榎本 由依, Suzuki Yasuaki, 北山 美登里, 重岡 学, 松本 耕祐, Kimoto Akira, Asai Tomoko, 竹内 純一郎, Komori Takahide
    第26回日本レーザー歯学会, Dec. 2014, Japanese, 日本レーザー歯学会, 東京, Domestic conference
    Poster presentation

  • 当科におけるインプラント242例907本埋入に関する臨床的検討
    川畑 真哉, Hasegawa Takumi, 今井 佑輔, Kimoto Akira, Akashi Masaya, Suzuki Yasuaki, Komori Takahide
    第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference
    Oral presentation

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例
    榎本 由依, Suzuki Yasuaki, Kimoto Akira, Hasegawa Takumi, Akashi Masaya, 竹内 純一郎, Komori Takahide
    第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference
    Oral presentation

  • 上顎洞底挙上術後の上顎洞粘膜肥厚の経時的変化に関する検討
    松本 耕祐, Suzuki Yasuaki, 筧 康正, Kimoto Akira, 李 進彰, Shibuya Yasuyuki, Komori Takahide
    第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference
    Oral presentation

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    Akashi Masaya, Shibuya Yasuyuki, 鰐渕 聡, Kimoto Akira, Hasegawa Takumi, Suzuki Yasuaki, Komori Takahide
    第18回日本顎顔面インプラント学会学術大会, Nov. 2014, Japanese, 日本顎顔面インプラント学会, 島根, Domestic conference
    Oral presentation

  • 当科における上顎洞底挙上術後の骨量変化の臨床的検討
    寺岡 駿, Suzuki Yasuaki, 筧 康正, 石田 優, Kimoto Akira, Hasegawa Takumi, Asai Tomoko, 竹内 純一郎, Shibuya Yasuyuki, Komori Takahide
    第59回日本口腔外科学会総会, Oct. 2014, Japanese, 日本口腔外科学会, 千葉, Domestic conference
    Oral presentation

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性
    Akashi Masaya, Furudoi Shungo, Minamikawa Tsutomu, Kimoto Akira, Sakakibara Akiko, Hasegawa Takumi, 後藤 育子, Shibuya Yasuyuki, Komori Takahide
    第68回日本口腔科学会学術総会, May 2014, Japanese, 日本口腔科学会, 東京, Domestic conference
    Oral presentation

  • レーザー治療後を含め経過観察中に癌化を認めた口腔白板症例の検討
    榎本由依, SUZUKI HIROAKI, 浅井知子, 安岡大介, 浅井雅敏, SHIGEOKA MANABU, 松本耕祐, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE
    第25回日本レーザー歯学会総会・学術大会, Sep. 2013, Japanese, 東京, Domestic conference
    Oral presentation

  • CO2レーザーにより切除された舌組織の病理組織学的診断に及ぼす障害の検討
    松本耕祐, SUZUKI HIROAKI, SHIGEOKA MANABU, KIMOTO AKIRA, 竹内純一郎, KOMORI TAKAHIDE
    第21回日本レーザー歯学会学術集会, Nov. 2009, Japanese, Domestic conference
    Oral presentation

  • Nd:YAGレーザーを用いた深部凝固療法により処置を行った口腔血管腫の16例
    SHIGEOKA MANABU, SUZUKI HIROAKI, 梶真人, KIMOTO AKIRA, 服部真季, 松本耕祐, 村田真穂, KOMORI TAKAHIDE
    第19回日本レーザー歯学会学術集会, Nov. 2007, Japanese, Domestic conference
    Oral presentation

■ Research Themes
  • 好中球に着眼したシェーグレン症候群の新規病理分類提案と治療薬探索
    後藤 育子, 西村 啓佑, 重岡 学, 木本 明, 明石 昌也, 明石 健吾, 筧 康正
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  • 顎骨壊死に対する腐骨分離促進療法の探索
    明石 昌也, 重岡 学, 有本 智美, 木本 明, 長谷川 巧実, 筧 康正
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026

  • 統合オミックス解析による口腔がん制御機構の解明と創薬標的の網羅的探索
    木本 明, 明石 昌也, 榎本 由依
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024
    口腔がんの大部分は扁平上皮癌であり、標準的治療は手術とされている。また、補助療法として放射線治療、化学療法が併用されることが多いが、進行がんに対しては予後が悪く、制御が可能であった場合でも患者自身のQOLを著しく低下させる。そのため、根治治療を目的としながらも、可能な限り機能を温存することも口腔がんにおいては重要である。現在、口腔がんに対する化学療法は、シスプラチン(CDDP)や5-FU、ドセタキセルが使用されている。しかし、進行がんを制御するまでは至っておらず、副作用も多い。本研究では、統合オミックス解析を行い、口腔がんに特異的な代謝経路を探索する。また、それに関わる代謝酵素のうち、がんの増殖の制御に関わるものを導き出し、その阻害剤の効果を検討することで、将来的な口腔がんの新たな治療薬の開発をめざす。 今年度は、まずヒト由来口腔がん細胞株（OSC-19、HSC-3）のガスクロマトグラフィー質量分析を実施した。また、口腔がん患者の血漿メタボローム解析を実施し、得られたデータを統計ソフトを用いて多変量解析することで、口腔がん患者に特異的な代謝物の変動を探索している。次に、ヒト由来口腔がん細胞株と血漿メタボローム解析の結果と比較することで、特に著明な変化を示す代謝経路の探索を開始している。今後は、これらに加え、口腔がん生体材料のメタボローム解析を実施することで、さらに口腔がん特異的な代謝経路を絞っていく予定である。

  • 血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索
    明石 昌也, 木本 明, 長谷川 巧実, 筧 康正
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2019 - 31 Mar. 2023
    骨粗鬆症などに対し用いられる骨吸収抑制薬や、口腔癌に対し施行される放射線照射等の医療行為が素因となる顎骨骨髄炎は、近年患者数の増加に伴い顎口腔外科領域において最も新たな治療法開発が期待される難治性疾患の一つである。本研究の目的は、近年感染の進展にも関与していることが明らかとなりつつある血管・リンパ管新生をターゲットとし、歯性感染症－顎骨骨髄炎移行メカニズムを解明することである。 研究の端緒として、まず血管新生のマーカーとなりうる分子の検討を行なった。近年動脈硬化や高血圧、腫瘍の増大における病的な状態における血管新生に関与している可能性が示唆されている血管内皮細胞間接着複合体構成分子に注目した。この分子についてはマウスやヒト培養細胞を用いた研究はこれまでに行われてきたが、ヒトの組織内での発現や局在部位を確認した報告は稀少であった。昨年度の研究結果より、この分子がヒトの組織内でも特に非炎症部位の血管に比べ炎症部位の微小血管等に発現が強く、病的な血管のマーカーとなり得る可能性が示唆され、この結果を英文査読付き学術誌に投稿し、採択された。次に、放射線性骨髄炎で顎骨内を感染がどのように侵入部から拡散し、特に顎関節方向へと拡散するのかを調査した。放射線性顎骨壊死では放射線性の影響と思われるダメージが皮質骨のすぐ内側で強く認められ、同部を介して感染が顎関節方向へ進展する可能性が考えられた。こうした下顎骨内をどのように感染が進展するかを手術検体を用いて詳細に調査した研究は希少であり、当該年度この研究成果を英文査読付き学術誌に投稿し、採択された。

  • 木本 明
    学術研究助成基金助成金／若手研究(B), Apr. 2017 - Mar. 2020, Principal investigator
    Competitive research funding

  • 鈴木 泰明
    学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020
    Competitive research funding

  • 古森 孝英
    学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2015 - Mar. 2018
    Competitive research funding

  • 鈴木 泰明
    学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017
    Competitive research funding

  • 木本 明
    学術研究助成基金助成金／若手研究(B), Apr. 2014 - Mar. 2017, Principal investigator
    Competitive research funding

  • 古森 孝英
    学術研究助成基金助成金／基盤研究(C), Apr. 2012 - Mar. 2015
    Competitive research funding

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