Research activity information

• Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice.

  Mariko Tsujimoto, Takeshi Fujita, Tatsuya Furukawa, Yaeno Arima, Ken-Ichi Nibu, Chikako Nishigori

  BACKGROUND: Xeroderma pigmentosum (XP) is caused by impaired DNA repair of UV-induced dipyrimidine-photoproducts. XP cells also show impaired repair/removal of ROS or oxidative DNA lesions caused by UV or 4-nitroquinolline 1-oxide (4NQO). Gene profiling indicated that inflammatory response-related genes are significantly upregulated after UV exposure in XP-A model mice. OBJECTIVE: Since XP cells are in the state of oxidative stress and inflammation, we aimed to search for therapeutic agents from anti-oxidants/anti-inflammatory drugs, that potentially improve XP symptoms. METHODS: Several antioxidants were examined for reducing 4NQO-induced oxidative cytotoxicity or UV-induced oxidative DNA damage in XP-A cells. Among them, we focused on melatonin and evaluated its improving effect for Xpa-deficient MEF on UV-induced cytotoxicity and ROS production, and for Xpa-deficient mice on UV-induced skin tumorigenesis and auditory brainstem responses as one of the neurological symptoms. RESULTS: Melatonin and nicotinamide attenuated 4NQO-induced oxidative cytotoxicity. UV-induced intracellular ROS production and cytotoxicity were improved by melatonin for Xpa-deficient MEF. Finally, the administration of melatonin mitigated UV-induced skin inflammation and tumorigenesis and suppressed hearing deterioration in Xpa-deficient mice. CONCLUSION: Our results show that melatonin could alleviate XP symptoms through its anti-inflammatory and antioxidant properties.

  Jan. 2025, Journal of dermatological science, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Oncological Outcomes of Concurrent Chemoradiotherapy and Surgical Treatment for Patients With T3 Hypopharyngeal Cancer: A Single-Center Retrospective Analysis.

  Mitsuko Yui, Yoshihisa Matsuno, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Naomi Kiyota, Tadashi Nomura, Daisuke Miyawaki, Ryohei Sasaki, Ken-Ichi Nibu

  Background Since the larynx and pharynx are vital for respiration, swallowing, and speech, chemoradiotherapy (CRT) has been widely applied for T3 hypopharyngeal cancer (HPC) as an organ-preserving treatment. However, CRT can lead to severe late adverse events such as dysphagia and aspiration pneumonia, especially in patients who have difficulty swallowing and/or aspiration at the time of initial diagnosis. Patients and methods Between 2012 and 2020, 86 patients with T3 HPC treated with curative intent at Kobe University Hospital were included in this study. The average age was 69 years old, ranging from 43 to 89. Diseases were classified as Stage III in 29 patients, Stage IVA in 52 patients, and Stage IVB in five patients. Thirty-five (41%) patients were treated by CRT, and 51 (59%) patients were treated by surgery. Patients were followed up for at least two years, and the follow-up period ranged from four to 128 months (median: 45 months). Results Three-year progression-free survival (PFS) rates of patients treated by CRT and patients treated by surgery were 56.2% and 60.3%, respectively. Three-year disease-specific survival (DSS) rates of patients treated by CRT and surgically treated patients were 79.0% vs. 70.8%, respectively. Three-year overall survival (OS) rates of patients treated by CRT and surgically treated patients were 64.5% and 69.0%, respectively. Of note, a significant difference was observed between three-year DSS and three-year PFS (79.0% vs. 56.2%, p = 0.0014) in the patients treated by CRT but not in the patients treated by surgery. Conclusions No significant differences were observed between the PFS, DSS, and OS rates of patients treated by CRT and those of surgically treated patients. Locoregional recurrences after CRT were significantly successfully salvaged by surgical intervention. These results suggest that CRT can be applied as an alternative to surgery without reducing survival, especially for patients without severe clinical symptoms. Meticulous follow-up is mandatory for early detection of recurrence to salvage by surgery and for the management of late adverse events.

  Jun. 2024, Cureus, 16(6) (6), e62553, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Induction of Immunological Antitumor Effects by the Combination of Adenovirus-Mediated Gene Transfer of B7-1 and Anti-Programmed Cell Death-1 Antibody in a Murine Squamous Cell Carcinoma Model.

  Makiko Hara, Sumiyo Saburi, Natsumi Uehara, Takahiro Tsujikawa, Mie Kubo, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Shigeru Hirano, Ken-Ichi Nibu

  BACKGROUND: The goal of this study was to evaluate the antitumor immune effects of B7-1 gene expression in addition to immune checkpoint inhibitor against squamous cell carcinoma. METHODS: A murine SCC cell line, KLN205, was infected with adenoviral vector carrying B7-1 (AdB7). Infected cells were injected subcutaneously in the flanks of DBA/2 mice. Three weeks after implantation, anti-mouse PD-1 antibody (antiPD1) was intraperitonially administrated twice a week for a total of six times. RESULTS: CD80 was significantly overexpressed in the AdB7-infected tumors. IFN-gamma in the T cells in the spleen was significantly increased and tumor size was significantly reduced in the mice treated with both AdB7 and antiPD1. Targeted tumors treated with both AdB7 and antiPD1 exhibited significantly increased cell densities of total immune cells as well as Ki-67+ CD8+ T cells and decreased regulatory T cells. CONCLUSIONS: These results suggest that the B7-1 gene transfer may enhance the antitumor effect of anti-PD1 antibody against SCC.

  Mar. 2024, Cancers, 16(7) (7), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Salvage surgery for mesenteric lymph node metastasis by resection of the first jejunal flap and reconstruction with the second jejunal flap.

  Daiki Kitano, Kazunobu Hashikawa, Tatsuya Furukawa, Tadashi Nomura, Kotaro Tamagawa, Shunsuke Sakakibara, Ken-Ichi Nibu, Hiroto Terashi

  We report a case of a second free jejunal transfer to treat metastasis in the mesenteric lymph node of the first jejunal flap. A 73-year-old man underwent total pharyngolaryngectomy, bilateral neck dissection, and free jejunal transfer for recurrent hypopharyngeal cancer [left pyriform sinus, pT2N0, moderately differentiated squamous cell carcinoma (SCC)] after radiotherapy. Seven years post-surgery, he underwent transoral videolaryngoscopic surgery for oropharyngeal cancer (soft palate, pT1N0, well-differentiated SCC). Ten years after the first jejunal transfer, metastasis was found in the mesenteric lymph node surrounding the jejunal flap's vascular pedicle. Under general anesthesia, resection of the first jejunum including the affected lymph node, and second jejunal transfer were performed. Lymph node pathological examination revealed poorly differentiated SCC, compatible with pharyngeal cancer metastasis. After neck dissection and jejunal flap transfer, lymphatic collateral pathways toward the flap's mesenteric lymph node might form. Possibly, hypopharyngeal or oropharyngeal cancer metastasized via this pathway.

  Dec. 2023, Journal of surgical case reports, 2023(12) (12), rjad686, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Corrigendum: Influences of Orogastric and Nasogastric Tubes on Sucking Pressure during Bottle Feeding in Immature Infants.

  Takeshi Komatsu, Tatsuya Furukawa, Daisuke Kobayashi, Sota Iwatani, Seiji Yoshimoto, Toshihiko Yamashita, Yumi Endo, Sayaka Katsunuma, Masahide Otsu, Ken-Ichi Nibu

  This corrects the article in Kobe J Med Sci. 2023 May 31; 69(1): E25-E32.

  Sep. 2023, The Kobe journal of medical sciences, 69(1) (1), S1, English, Domestic magazine


• Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single-center study.

  Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.

  Jul. 2023, Head & neck, English, International magazine

  Scientific journal


• OK432 sclerotherapy for refractory chylous leakage after neck dissection.

  Yuiko Hashimoto, Masanori Teshima, Mitsuko Yui, Shun Tatehara, Keisuke Iritani, Tatsuya Furukawa, Hirotaka Shinomiya, Ken-Ichi Nibu

  Chylous leakage is a rare but serious postoperative complication of neck dissection (ND). Most chylous leakages are successfully treated either by drainage or ligation of the thoracic duct, but the resolution is occasionally prolonged. OK432 sclerotherapy is used to treat various refractory cystic diseases of the head and neck. Three patients were treated with OK432 sclerotherapy for refractory chylous leakage following ND. Case 1 involved a 77-year-old man with chylous leakage after a total laryngectomy and bilateral ND. Case 2 involved a 71-year-old woman who underwent total thyroidectomy and left ND for thyroid cancer. Case 3 involved a 61-year-old woman who underwent right ND for oropharyngeal cancer. In all patients, chylous leakage rapidly improved after OK432 injection without any complications. Our results suggest the efficacy of OK432 sclerotherapy in patients with refractory chylous leakage after ND.

  Jun. 2023, Journal of surgical case reports, 2023(6) (6), rjad310, English, International magazine

  Link to Kobe Univ. Repository (Kernel)


• Influences of Orogastric and Nasogastric Tubes on Sucking Pressure during Bottle Feeding in Immature Infants.

  Takeshi Komatsu, Tatsuya Furukawa, Daisuke Kobayashi, Sota Iwatani, Seiji Yoshimoto, Toshihiko Yamashita, Yumi Endo, Sayaka Katsunuma, Masahide Otsu, Ken-Ichi Nibu

  Orogastric (OG) and nasogastric (NG) tubes have been reported to delay breastfeeding initiation and affect respiratory function. However, the effects of feeding tubes on sucking pressure have not been well studied. Fourteen preterm infants were enrolled in this study, and their sucking pressures during bottle feeding with an OG tube, NG tube, and without any tube were measured. Sucking pressure significantly increased after changing the OG tube to an NG tube (p = 0.044). However, sucking pressure showed no significant differences after changing the feeding method from an NG tube to oral intake. Thus, NG tubes are superior to OG tubes in terms of sucking pressure.

  Corresponding, May 2023, The Kobe journal of medical sciences, 69(1) (1), E25-E32, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Incidence and spread pattern of lymph node metastasis from submandibular gland cancer.

  Kotaro Tamagawa, Naoki Otsuki, Hikari Shimoda, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu

  OBJECTIVES: To clarify the indication of neck dissection (ND) for patient with submandibular gland (SMG) cancer. METHODS: A total of 43 patients with SMG cancer were retrospectively analyzed. Forty-one patients underwent ND: Levels I-V in 19 patients, Levels I-III in 18 patients, and Level Ib in 4 patients. The other two patients did not undergo ND, since preoperative diagnoses were benign. Postoperative radiotherapy was performed in 19 patients with positive surgical margin, high grade cancer or stage IV disease. RESULTS: LN metastases were pathologically confirmed in all patients with cN + and 6 out of 31 patients with cN-. No patients developed regional recurrence during follow-up periods. Ultimately, LN metastases were pathologically confirmed in 17 of 27 high grade, one out of 9 intermediate grade, but not in 7 low grade. CONCLUSIONS: Prophylactic neck dissection should be considered in T3/4 and high grade SMG cancers.

  May 2023, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 280(9) (9), 4233 - 4238, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 顎二腹筋後腹の浅層を走行する外頸動脈の1例

  有吉 偉雄, 古川 竜也, 四宮 弘隆, 入谷 啓介, 蓼原 瞬, 丹生 健一

  (株)医学書院, Nov. 2022, 耳鼻咽喉科・頭頸部外科, 94(12) (12), 1055 - 1058, Japanese


• Expressions of NeuroD and GAP43 as diagnostic markers for olfactory neuroblastoma.

  Tatsuya Furukawa, Shun Tatehara, Masanori Teshima, Hirotaka Shinomiya, Go Inokuchi, Masato Komatsu, Shigeo Hara, Yoh Zen, Ken-Ichi Nibu

  OBJECTIVE: Olfactory neuroblastoma (ONB) is often difficult to pathologically distinguish from other small round cell tumors (SRCTs) arising in the nasal cavities. Although there are several diagnostic markers used for differential diagnosis of ONB, these molecules are also expressed in various neuronal derived tumors. Here, we examined the expression of NeuroD, GAP43, and olfactory marker protein (OMP) in ONB and non-ONB SRCT to determine their utility in the differential diagnosis of ONB. METHODS: Twenty-six patients diagnosed with and treated for ONB at Kobe University Hospital between 1997 and 2017 with formalin-fixed, paraffin-embedded biopsy or surgical resection specimens were included. The expressions of NeuroD, GAP43, and OMP were immunohistochemically examined in these 26 ONB specimens and specimens from 13 SRCTs arising in the nasal cavities for reference. RESULTS: Among the 26 ONB samples, focal, patchy, and marked staining for NeuroD was observed in 4, 3, and 9 samples, respectively. Focal, patchy, and marked GAP43 staining was observed in 5, 3, and 11 samples, respectively. Consequently, marked positive staining for either NeuroD or GAP43 was observed in 54% (14/26) of ONBs. Among the 13 SRCTs, marked staining for NeuroD was observed in two small cell carcinomas, one undifferentiated carcinoma, and one neuroendocrine carcinoma, whereas marked positive staining for GAP43 was observed only in one undifferentiated carcinoma. No specimen in this study exhibited OMP staining. CONCLUSIONS: Our results suggest possible roles of GAP43 immunostaining in the differential diagnosis of ONB.

  Aug. 2022, Auris, nasus, larynx, 50(3) (3), 358 - 364, English, International magazine

  [Refereed]

  Scientific journal


• Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer.

  Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu

  OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.

  Corresponding, Jun. 2022, Auris, nasus, larynx, 49(3) (3), 477 - 483, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における喉頭全摘術後の気管孔狭窄症例の臨床的観察と介入

  高橋 美貴, 岩城 忍, 入谷 啓介, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一

  (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 187 - 187, Japanese


• 耳下部腫瘤を唯一の症状とした慢性活動性EBウィルス感染症(CAEBV)の1例

  下田 光, 手島 直則, 藤原 肇, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 丹生 健一

  (一社)日本頭頸部癌学会, May 2022, 頭頸部癌, 48(2) (2), 230 - 230, Japanese


• Efficacy of a High-definition Three-dimensional Exoscope in Simultaneous Transcranial and Endoscopic Endonasal Surgery: A Case Report.

  Ayaka Shibano, Hidehito Kimura, Shun Tatehara, Tatsuya Furukawa, Kazuki Inoue, Yuichi Fujita, Hiroaki Nagashima, Shunsuke Yamanishi, Tadashi Nomura, Ken-Ichi Nibu, Takashi Sasayama

  Owing to recent advances in medical optical technology, a high-definition (4K) three-dimensional (3D) exoscope has been developed as an alternative tool to using conventional microscopes for microscopic surgery, and its efficacy for neurosurgery has been reported. We report a case who underwent simultaneous surgery aiming for en bloc resection of an anterior skull base malignancy with concurrent exoscopic transcranial and endoscopic endonasal approaches using a 4K 3D exoscope. The patient was a 76-year-old woman who underwent en bloc resection for an anterior skull base olfactory neuroblastoma 13 years ago. After confirming the recurrence of progressive olfactory neuroblastoma, tumor resection was again decided to be performed. As with the first procedure, surgery was performed in an en bloc manner, using both transcranial and endonasal approaches. Exoscope provided enough space above the surgical field to allow us to perform transcranial and endonasal surgeries simultaneously. Moreover, the surgeons could maintain a comfortable posture throughout the procedure, and total tumor removal was successfully achieved without any abnormal event. To our knowledge, this is the first report of the introduction of an exoscope aiming for en bloc resection of an anterior skull base malignancy while performing simultaneous surgery with both transcranial and endonasal approaches. We believe that the more cases are accumulated, the more efficacy of a 4K 3D exoscope will be elucidated.

  2022, NMC case report journal, 9, 243 - 247, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Two cases of glottic closure for refractory aspiration pneumonia after vertical partial laryngectomy.

  Tatsuya Furukawa, Kotaro Tamagawa, Kenta Fukui, Shinobu Iwaki, Miki Takahashi, Keisuke Iritani, Hirotaka Shinomiya, Masanori Teshima, Naoki Otsuki, Makoto Kano, Ken-Ichi Nibu

  Vertical partial laryngectomy is a well-established surgical procedure for early glottic cancers with acceptable functional and oncological outcomes. However, on a long-term basis, aspiration might be a serious problem with aging. Here we presented two cases of refractory aspiration pneumonia after vertical laryngectomy. Case 1: A 76-year old gentleman with a past history of malignant lymphoma treated by chemotherapy and radiotherapy had glottic cancer, which was treated by repeated vertical partial laryngectomies. Although glottic caner had been well controlled, he started to suffer from refractory aspiration pneumonia. Since his cervical skin was very thin and hard and his general condition was poor, we employed modified Kano's method for glottic closure. Case 2: A 87-year old Japanese male had a past history of glottic cancer treated by radiotherapy and vertical partial laryngectomy. He was repeatedly hospitalized for severe aspiration pneumonia. At the age of 87, he had second primary oropharyngeal cancer. Kano's method was simultaneously performed at the time of resection of oropharyngeal cancer. Postoperative courses were uneventful without sign of leakage in both cases. The patients started oral intake 2 weeks after the surgery. They have been alive without aspiration pneumonia and takes normal diet.

  Lead, Dec. 2021, Auris, nasus, larynx, 48(6) (6), 1221 - 1225, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における喉頭全摘出術後の代用音声と永久気管孔の管理に対する言語聴覚士介入の重要性について

  高橋 美貴, 岩城 忍, 入谷 啓介, 蓼原 瞬, 古川 竜也, 手島 直則, 四宮 弘隆, 丹生 健一

  (一社)日本頭頸部癌学会, Oct. 2021, 頭頸部癌, 47(3) (3), 322 - 328, Japanese


• Prognostic factors after transoral resection of early hypopharyngeal cancer.

  Keisuke Iritani, Daryl Anne A Del Mundo, Shinobu Iwaki, Kuriko Masuda, Maki Kanzawa, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Koichi Morimoto, Naoki Otsuki, Ken-Ichi Nibu

  Objective: This study aimed to investigate risk factors predictive of local recurrence and/or lymph node metastasis after transoral resection of early hypopharyngeal cancer. Methods: Forty-nine consecutive patients who underwent transoral videolaryngoscopic surgery (TOVS) as an initial treatment for hypopharyngeal cancer were evaluated. On univariate and multivariate analysis, local recurrence rates were assessed respectively using log-rank test and cox regression analysis according to the following parameters: subsite, pT, mucosal margin, lymphatic invasion, vessel invasion, tumor thickness (> 4 mm vs ≤4 mm), history of esophageal cancer, and multiple Lugol-voiding lesions (LVLs) in the esophagus. Categorical variables were evaluated for their associations with lymph node metastasis using chi-squared test or Fisher's exact test. Result: The subsites of primary lesions were piriform sinus in 24 patients, posterior wall in 15 patients, and postcricoid in 10 patients. Thirty patients had esophageal cancer. Local recurrence occurred in 14 patients. Three patients had lymph node metastasis at the time of diagnosis and four patients developed lymph node metastasis after the initial treatment, resulting a total of seven patients having lymph node metastasis. While mucosal margin and LVLs showed significant associations with local recurrence on univariate analysis, only LVLs remained as a significant risk factor on multivariate analysis (P = .0395; hazard ratio = 8.897; 95% confidence interval, 1.113-71.15). Most cases of local recurrence were satisfactorily controlled by repeated TOVS. While multivariate analysis could not be performed due to the small number of the patients with lymph node metastases, venous invasion (P = .0166) and tumor thickness (P = .0092) were significantly associated with lymph node metastasis on univariate analysis. Conclusions: Local recurrence was more frequent in patients with LVLs, but most of them were salvaged by repeated TOVS. Patients with venous invasion and/or tumor thickness greater than 4 mm should be followed up with special attention to lymph node metastasis.Level of Evidence: 3.

  Aug. 2021, Laryngoscope investigative otolaryngology, 6(4) (4), 756 - 763, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科で経験した非反回下喉頭神経の4症例

  三根 実穂子, 下田 光, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 手島 直則, 大月 直樹, 丹生 健一

  (NPO)日本頭頸部外科学会, Feb. 2021, 頭頸部外科, 30(3) (3), 367 - 372, Japanese


• The prospective evaluation and risk factors of dysphagia after surgery in patients with oral cancer.

  Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi

  BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.

  Jan. 2021, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Society of swallowing and dysphagia of Japan: Position statement on dysphagia management during the COVID-19 outbreak.

  Yurika Kimura, Rumi Ueha, Tatsuya Furukawa, Fumiko Oshima, Junko Fujitani, Junko Nakajima, Asako Kaneoka, Hisaaki Aoyama, Yasushi Fujimoto, Toshiro Umezaki

  On April 14, the Society of Swallowing and Dysphagia of Japan (SSDJ) proposed its position statement on dysphagia treatment considering the ongoing spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main routes of transmission of SARS-CoV-2 are physical contact with infected persons and exposure to respiratory droplets. In cases of infection, the nasal cavity and nasopharynx have the highest viral load in the body. Swallowing occurs in the oral cavity and pharynx, which correspond to the sites of viral proliferation. In addition, the possibility of infection by aerosol transmission is also concerning. Dysphagia treatment includes a broad range of clinical assessments and examinations, dysphagia rehabilitation, oral care, nursing care, and surgical treatments. Any of these can lead to the production of droplets and aerosols, as well as contact with viral particles. In terms of proper infection control measures, all healthcare professionals involved in dysphagia treatment must be fully briefed and must appropriately implement all measures. In addition, most patients with dysphagia should be considered to be at a higher risk for severe illness from COVID-19 because they are elderly and have complications including heart diseases, diabetes, respiratory diseases, and cerebrovascular diseases. This statement establishes three regional categories according to the status of SARS-CoV-2 infection. Accordingly, the SSDJ proposes specific infection countermeasures that should be implemented considering 1) the current status of SARS-CoV-2 infection in the region, 2) the patient status of SARS-CoV-2 infection, and 3) whether the examinations or procedures conducted correspond to aerosol-generating procedures, depending on the status of dysphagia treatment. This statement is arranged into separate sections providing information and advice in consideration of the COVID-19 outbreak, including "terminology", "clinical swallowing assessment and examination", "swallowing therapy", "oral care", "surgical procedure for dysphagia", "tracheotomy care", and "nursing care". In areas where SARS-CoV-2 infection is widespread, sufficient personal protective equipment should be used when performing aerosol generation procedures. The current set of statements on dysphagia management in the COVID-19 outbreak is not an evidence-based clinical practice guideline, but a guide for all healthcare workers involved in the treatment of dysphagia during the COVID-19 epidemic to prevent SARS-CoV-2 infection.

  Oct. 2020, Auris, nasus, larynx, 47(5) (5), 715 - 726, English, International magazine

  Scientific journal


• Salvage surgery for structural local recurrence of papillary thyroid cancer: recurrence patterns and surgical outcome.

  Naoki Otsuki, Hikari Shimoda, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu

  To clarify the patterns of the recurrence and to assess the oncological and functional outcomes after salvage surgery for the patients with structural local recurrence of papillary thyroid cancer (PTC), twenty-five patients who underwent salvage surgery for structural local recurrence of PTC were retrospectively reviewed. Structural recurrences were observed in the tracheal lumen in 5 patients, intraluminal or intramuscular esophagus in 5 patients, trachea, and cricoid cartilage in 9 patients, cricoid and thyroid cartilage in 2 patients, intra-lumen of the larynx in 1 patient and soft tissue around thyroid in 3 patients, respectively. Although all local disease was resected with macroscopically negative margin, 10 patients diagnosed as microscopically positive margin. Major surgical complications occurred in 6 patients, including common carotid artery injury (n = 1), unintentional pharyngeal or esophageal injury (n = 2), recurrent laryngeal nerve paralysis (n = 2), and pharyngeal fistula resulting in common carotid artery rupture (n = 1), and were successfully managed. During the follow-up periods, 6 patients were alive without disease, 15 patients survived with distant metastases and/or locoregional recurrence, and 4 patients died of the disease. While tracheocutaneous fistula remained in 7 patients, the vocal function was preserved in all patients but one who underwent total laryngectomy. Normal oral intake was retained in all patients. In conclusion, although salvage surgery for structural recurrence of PTC has a high risk of complications, it may be worthwhile when macroscopic curative resection is available. The decision should be made considering various factors including curability, risk of surgical procedure, functional outcome, and life expectancy.

  Sep. 2020, Endocrine journal, 67(9) (9), 949 - 956, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 新型コロナウイルス感染症流行期における嚥下障害診療指針

  木村 百合香, 上羽 瑠美, 古川 竜也, 巨島 文子, 藤谷 順子, 中島 純子, 兼岡 麻子, 青山 寿昭, 藤本 保志, 梅崎 俊郎, 日本嚥下医学会新型コロナウイルス感染対策委員会

  日本嚥下医学会, Sep. 2020, 嚥下医学, 9(2) (2), 174 - 188, Japanese


• 声門閉鎖術後の代替コミュニケーションと経口摂取についての検討

  高橋 美貴, 古川 竜也, 涌井 絵美, 岩城 忍, 入谷 啓介, 四宮 弘隆, 丹生 健一

  日本嚥下医学会, Sep. 2020, 嚥下医学, 9(2) (2), 221 - 227, Japanese


• 総頸動脈破裂を救命し得た再発頭頸部癌の4例

  入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 大月 直樹, 丹生 健一

  (NPO)日本頭頸部外科学会, Jun. 2020, 頭頸部外科, 30(1) (1), 105 - 112, Japanese


• Left non-recurrent inferior laryngeal nerve in a patient with right-sided aortic arch and aberrant left subclavian artery.

  Tatsuya Furukawa, Naoki Otsuki, Masahiro Tomotsu, Shun Tatehara, Naruhiko Morita, Yasutaka Kojima, Masanori Teshima, Hirotaka Shinomiya, Ken-Ichi Nibu

  Non-recurrent inferior laryngeal nerve (NRILN) is rare but one of the important anatomical variations in thyroid and parathyroid surgery. Almost all cases were observed on the right side with aberrant right subclavian artery and left NRILN have been reported in only five cases so far. Here, we reported a 38 year-old Japanese male with left NRILN accompanying adenomatous goiter. He was referred to our hospital for the surgical treatment of left thyroid goiter. Preoperative computed tomography revealed right-sided aortic arch and aberrant left subclavian artery with no signs of complete situs inversus viscerum, suggesting possible left NRLN. Left hemithyroidectomy was performed using nerve monitoring system. Intraoperatively, left recurrent laryngeal nerve was not identified along tracheoesophageal groove, but directly originated from vagal nerve and was running horizontally to larynx. Mobility of vocal cords were not impaired and postoperative course was uneventful. During thyroid surgery for the patients with right-sided aortic arch, meticulous care should be taken using nerve monitoring system to avoid nerve injury.

  Mar. 2020, Auris, nasus, larynx, 48(2) (2), 317 - 321, English, International magazine

  [Refereed]

  Scientific journal


• 甲状腺癌に対する甲状腺全摘術後の副甲状腺機能の検討

  大月 直樹, 下田 光, 古川 竜也, 四宮 弘隆, 手島 直則, 丹生 健一

  (NPO)日本頭頸部外科学会, Feb. 2020, 頭頸部外科, 29(3) (3), 259 - 265, Japanese


• 【舌がん・口腔がん治療の最前線】支持療法 嚥下障害への対応戦略 術前評価から誤嚥防止手術まで

  古川 竜也, 丹生 健一

  (株)医学書院, Dec. 2019, 耳鼻咽喉科・頭頸部外科, 91(13) (13), 1155 - 1163, Japanese


• ANL Secondary Publication 甲状腺癌に対する甲状腺全摘後の術後副甲状腺機能低下症について

  手島 直則, 大月 直樹, 下田 光, 森田 成彦, 古川 竜也, 四宮 瞳, 四宮 弘隆, 丹生 健一

  (一社)日本耳鼻咽喉科学会, Dec. 2019, 日本耳鼻咽喉科学会会報, 122(12) (12), 1561 - 1562, Japanese


• Modified spiral tracheoplasty after extensive window resection of trachea for advanced thyroid cancer.

  Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hirotaka Shinomiya, Masanori Teshima, Yasutaka Kojima, Ken-Ichi Nibu

  Papillary thyroid carcinoma (PTC) occasionally invades tracheal cartilages. We adapted a reconstructive procedure "modified spiral tracheoplasty" to extensive tracheal defect after resection of locally advanced thyroid cancer. Extensive window resection of tracheal wall was performed in a 72-year-old woman and a 48-year-old man with PTC invading intraluminal trachea. Remaining stumps of trachea were separated from the esophageal wall and were rotated by 90 degrees in opposite directions. Posterior and lateral walls were anastomosed and tracheocutaneous fistula was created to prevent postoperative airway obstruction. Postoperative course was uneventful in both cases. Tracheocutaneous fistula was successfully closed 3 to 4 months after the initial surgery. Modified spiral tracheoplasty is a safe and useful method to recreate a framework of trachea after extensive window resection for advanced thyroid cancer.

  Dec. 2019, Auris, nasus, larynx, 46(6) (6), 946 - 951, English, International magazine

  [Refereed]

  Scientific journal


• 【嚥下障害を診る!-プロに学ぶ実践スキル】病態と診断 超高齢社会における嚥下トリアージ

  上岡 美和, 古川 竜也, 丹生 健一

  (株)医学書院, Sep. 2019, 耳鼻咽喉科・頭頸部外科, 91(10) (10), 818 - 823, Japanese


• Oncologic and functional outcomes of transoral CO2 laser cordectomy for early glottic cancer.

  Del Mundo DAA, Morimoto K, Masuda K, Iwaki S, Furukawa T, Teshima M, Shinomiya H, Miyawaki D, Otsuki N, Sasaki R, Nibu KI

  OBJECTIVE: To investigate the oncological and functional outcomes of the patients treated with transoral CO2 laser cordectomy for early glottic cancer. PATIENTS AND METHODS: Fifty-five consecutive patients who underwent CO2 laser cordectomy for early glottic cancer were retrospectively reviewed. RESULTS: Overall survival, larynx preservation, and relapse free local control rates were 96%, 100%, and 91%, respectively. Five patients with local recurrences were salvaged with re-cordectomy and/or radiotherapy. In type I cordectomy, VHI-10 consistently improved during postoperative course and VHI-10 at postoperative 12months was significantly better than preoperative value (2.3 vs. 9.4, p=0.02). Perceptual grading, MPT, MFR and AC/DC also improved and were better than preoperative values. In type III cordectomy, shimmer at 12months after cordectomy was significantly better than preoperative value (14.7 vs. 9.3, p=0.007). CONCLUSIONS: These results further support the rationale of CO2 cordectomy as initial and salvage surgery for early glottic cancer.

  Sep. 2019, Auris, nasus, larynx, 47(2) (2), 276 - 281, English, International magazine

  [Refereed]

  Scientific journal


• Functional and oncological outcomes after retropharyngeal node dissection for papillary thyroid carcinoma.

  Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu

  BACKGROUND: Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare. PATIENTS AND METHODS: We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases. RESULTS: Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. RPLN metastasis arose unilaterally in 15 patients and bilaterally in 1 patient. Eleven patients showed temporal dysphagia and four patients showed temporal vocal cord paralysis, but both symptoms eventually recovered in all cases. Two patients with salvage RPLN dissection died of distant metastasis and six patients survived with distant metastasis and/or persistent loco-regional disease. Other eight patients have been alive without disease. CONCLUSIONS: Although transcervical approach for RPLN metastases of PTC provided acceptable functional and oncological outcomes, half of the patients with RPLN metastasis have had distant metastasis and/or persistent locoregional disease. Indications of surgery for patients with RPLN metastasis need to be performed carefully in consideration of patients' prognosis and quality of life.

  Jun. 2019, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 276(6) (6), 1809 - 1814, English, International magazine

  [Refereed]

  Scientific journal


• Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer.

  Masanori Teshima, Naoki Otsuki, Hirotaka Shinomiya, Naruhiko Morita, Tatsuya Furukawa, Koichi Morimoto, Tetsu Nakamura, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  OBJECTIVES: To evaluate the impact of retropharyngeal lymph node (RPLN) dissection in the surgical treatment of hypopharyngeal cancer. METHODS: Between 2007 and 2016, 98 previously untreated patients with pathological diagnosed hypopharyngeal squamous cell carcinoma underwent total pharyngolaryngectomy and bilateral neck dissection at Kobe University Hospital. Bilateral dissection of RPLN was simultaneously performed in all patients. Pharynx was reconstructed with free jejunal transfer in 94 patients and primarily closed in 4 patients. Postoperative chemoradiotherapy was performed in patients with high risk factors including metastasis to RPLN, multiple lymph node metastasis, extranodal invasion, and/or positive/close surgical margins. RESULTS: The median follow-up period was 25 months ranging from 1 to 105 months. RPLN adenopathy was preoperatively identified in 9 patients in FDG-positron emission tomography. All of them had pathologically diagnosed RPLN metastases, which had been controlled in all patients during the observation periods. Among the other 89 patients, 7 patients had RPLN metastasis. The 2-year overall survival rates of the patients with and without RPLN metastasis were 65.7% and 69.8% (P = .61), respectively. CONCLUSIONS: In the present study, patients with RPLN metastasis showed equally favorable oncological outcome compared with patients without RPLN metastasis. At least, ipsilateral RPLN dissection should be considered in the surgical treatment of advanced hypopharyngeal cancer and multiple neck lymph node metastasis regardless of primary subsite.

  Jun. 2019, Head & neck, 41(6) (6), 1738 - 1744, English, International magazine

  [Refereed]

  Scientific journal


• Results of free flap reconstruction for patients aged 80 years or older with head and neck cancer.

  Otsuki N, Furukawa T, Avinçsal MO, Teshima M, Shinomiya H, Oshikiri T, Nakamura T, Nomura T, Hashikawa K, Nibu KI

  OBJECTIVE: Free flap reconstruction in elderly patients is one of the most challenging surgeries in the treatment of head and neck cancers. The aim of this study was to examine the oncological and functional outcomes of free flap reconstruction for elderly patients with head and neck cancer. METHODS: We retrospectively reviewed elderly patients who underwent free flap reconstruction for the treatment of head and neck cancers. All patients were 80 years or older. Clinicopathologic features, surgical procedures, oncological and functional outcomes were obtained from medical records. RESULTS: Free flap reconstructions were performed in 13 patients (3 female, 10 male). The mean age was 82.6 ± 3.4 years (range: 80-91). The mean follow-up period was 23.3 months (range 4-41 months). The mean disease-free survival was 49 ± 6 months (range 4-60 months). All patients had been alive more than one year after surgery. Reconstruction was performed using free jejunum in 10 patients and radial forearm flap in 3 patients. Graft necrosis occurred in 2 patients. Other two patients experienced major postoperative medical complications. CONCLUSION: Free flap reconstruction in well-selected older adults is safe and effective. Advanced age should not preclude consideration of free flap reconstruction in those patients.

  May 2019, Auris, nasus, larynx, 47(1) (1), 123 - 127, English, International magazine

  [Refereed]

  Scientific journal


• A laryngeal closure technique for the treatment of patients with head and neck cancer: Laryngeal closure technique for HNC patients

  HirokazuKomatsu, HisamiFujio, YasutakaKojima, NaruhikoMorita, MasanoriTeshima, HirotakaShinomiya, KoichiMorimoto, NaokiOtsuki, MakotoKano, Ken-ichiNibu

  BACKGROUND: In 2008, Kano developed a new laryngeal closure technique (Kano's method) for the treatment of severe aspiration. The aim of this study was to evaluate the safety and efficacy of this technique in patients with head and neck cancer. METHODS: Since June 2014 until March 2018, six patients underwent Kano's method for management of severe aspiration after the treatment of head and neck cancers. The anterior parts of the thyroid and the cricoid cartilages were excised widely. The glottis was closed by suturing bilateral vocal folds and reinforced by the sternohyoid muscle. A tracheostoma was created with skin flaps, subglottic mucosal flaps, and stumps of cricoid and trachea cartilages. RESULTS: No severe complications were observed after the surgery. Oral intake improved without developing aspiration. CONCLUSIONS: Kano's method can provide satisfactory functional results with minimal invasion for treating severe aspiration after advanced surgery, chemotherapy, and/or chemoradiotherapy, in patients with head and neck cancer. LEVEL OF EVIDENCE: 4.

  Jan. 2019, Laryngoscope Investig Otolaryngol, 4(2) (2), 246 - 249, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer.

  Masanori Teshima, Naoki Otsuki, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Hirotaka Shinomiya, Ken-Ichi Nibu

  OBJECTIVES: Postoperative hypoparathyroidism (HPT) is one of the most common complications in total thyroidectomy for thyroid carcinoma. Parathyroid glands (PTGs) are at risk of being damaged during total thyroidectomy and central neck dissection mainly due to inadvertent removal, interruption of the blood supply or hematoma formation. The purpose of this study was to evaluate the efficacy of our surgical procedure to preserve for parathyroid function retrospectively and to clarify the risk factors of HPT after total thyroidectomy for thyroid cancer. PATIENTS AND METHODS: Sixty-five patients undergoing total thyroidectomy with central neck dissection for thyroid cancer were enrolled in this retrospective study. Cancers were diagnosed as stage I in 15 patients, stage II in 24 patients, stage III in 19 patients, and stage IV in 7 patients. Lateral neck dissection and upper mediastinal dissection were simultaneously performed in 47 patients and one patient, respectively. Parathyroid glands (PTGs) were preserved in situ in 34 patients. Among 31 patients in whom PTG could not be preserved in situ, two or more PTGs were autotransplanted in 9 patients and one PTG was autotransplanted in 18 patients. PTG was not autotransplanted in 4 patients, since it could not be identified during the surgery. RESULTS: Postoperative transient HPT and permanent HPT were observed in 44 (68%) patients and in 12 (18%) patients, respectively. Among 34 patients in whom PTGs were preserved in situ, transient HPT and permanent HPT were observed in 17 (50%) patients and in 6 (2%) patients, respectively. Among 31 patients in whom PTG were not preserved in situ, postoperative permanent HPT was observed in all 4 patients without PTG autotransplantation, and 6 (33%) out of the 18 patients who had one PTG autotransplantation. On the other hand, none of the 9 patients who had two or more PTG autotransplantation at the time of thyroidectomy developed permanent HPT (P=0.04). The patients with large tumor (≥40mm) and/or gross extra glandular invasion had a significantly higher risk of permanent postoperative HPT compared with the patients without these pathological features (P<0.01). CONCLUSIONS: Two or more PTG should be autotransplanted in case where PTG is not preserved in situ to prevent postoperative HPT after total thyroidectomy with central neck dissection, especially in cases of large tumor and/or gross extrathyroidal extension.

  Dec. 2018, Auris, nasus, larynx, 45(6) (6), 1233 - 1238, English, International magazine

  [Refereed]

  Scientific journal


• Transoral videolaryngoscopic surgery for papillary carcinoma arising in lingual thyroid.

  Chisato Mogi, Hirotaka Shinomiya, Natsumi Fujii, Tomoyuki Tsuruta, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Maki Kanzawa, Mitsuyoshi Hirokawa, Naoki Otsuki, Ken-Ichi Nibu

  Carcinoma arising in lingual thyroid is an extremely rare entity accounting for only 1% of all reported ectopic thyroids. Here, we report a case of carcinoma arising in lingual thyroid, which has been successfully managed by transoral resection and bilateral neck dissections. A lingual mass 4-cm in diameter with calcification was incidentally detected by computed tomography at medical check-up. No thyroid tissue was observed in normal position. Ultrasound examination showed bilateral multiple lymphadenopathies. Fine needle aspiration biopsy from lymph node in his right neck was diagnosed as Class III and thyroglobulin level of the specimen was 459ng/ml. Due to the difficulty in performing FNA of the lingual masses, right neck dissection was performed in advance for diagnostic purpose. Pathological examination showed existence of large and small follicular thyroid tissues in several lymph nodes, suggesting lymph node metastasis from thyroid carcinoma. Two months after the initial surgery, video-assisted transoral resection of lingual thyroid with simultaneous left neck dissection was performed. Postoperative course was uneventful. Papillary carcinoma was found in the lingual thyroid and thyroid tissues were also found in left cervical lymph nodes. Video-assisted transoral resection was useful for the treatment of thyroid cancer arising in lingual thyroid.

  Oct. 2018, Auris, nasus, larynx, 45(5) (5), 1127 - 1129, English, International magazine

  [Refereed]

  Scientific journal


• 下咽頭癌CRT後に発症した腸管気腫症および門脈ガス血症の1例

  下田 光, 魚住 真樹, 橋本 大, 古川 竜也

  (一社)日本頭頸部癌学会, Apr. 2018, 頭頸部癌, 44(1) (1), 28 - 31, Japanese


• Epigenetic down-regulation of SOX2 is an independent poor prognostic factor for hypopharyngeal cancers.

  Mehmet Ozgur Avincsal, Naoe Jimbo, Kohei Fujikura, Hirotaka Shinomiya, Naoki Otsuki, Koichi Morimoto, Tatsuya Furukawa, Naruhiko Morita, Ritsuko Maehara, Tomoo Itoh, Ken-Ichi Nibu, Yoh Zen

  AIMS: We recently reported that a small subset (7%) of oesophageal squamous cell carcinomas completely lacking SOX2 expression had unique clinicopathological features and a dismal prognosis. The aim of the present study was to elucidate whether the findings obtained in oesophageal cancers are applicable to hypopharyngeal squamous cell carcinomas (HPSCCs) or oropharyngeal squamous cell carcinomas (OPSCCs). METHODS AND RESULTS: The study cohort consisted of consecutive patients with HPSCC (n = 130) and OPSCC (n = 65) who underwent surgery without preoperative therapy. On immunostaining, SOX2 was almost entirely negative in 10 of 130 HPSCCs (8%) and seven of 65 OPSCCs (11%). No significant differences were observed in clinicopathological features, including p16 status, between SOX2-positive and SOX2-negative cancers. However, patients with SOX2-negative HPSCC had significantly worse overall and recurrence-free survival than those with SOX2-positive HPSCC, whereas such a prognostic relationship was not confirmed in patients with OPSCC. In a multivariate analysis, the loss of SOX2 expression appeared to be an independent poor prognostic factor for patients with HPSCC. In a sequencing analysis, no mutation was found in SOX2. As SOX2 is known to contain an extensive CpG island before the transcription start site, methylation-specific polymerase chain reaction for the SOX2 promoter was performed. Methylated alleles were found in nine of 10 SOX2-negative HPSCCs but in none of SOX2-positive HPSCCs. CONCLUSIONS: Similarly to oesophageal cancers, a small subset (8%) of HPSCCs characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing.

  Apr. 2018, Histopathology, 72(5) (5), 826 - 837, English, International magazine

  [Refereed]

  Scientific journal


• 【ここが知りたい! 高齢化時代の頭頸部がん診療】術後摂食嚥下障害への対応

  古川 竜也, 丹生 健一

  (株)医学書院, Jul. 2017, 耳鼻咽喉科・頭頸部外科, 89(8) (8), 609 - 615, Japanese


• Isosorbide-Induced Decompression Effect on the Scala Media: Participation of Plasma Osmolality and Plasma Arginine Vasopressin.

  Taizo Takeda, Setsuko Takeda, Natsumi Uehara, Shungaku Yanagisawa, Tatsuya Furukawa, Ken-Ichi Nibu, Akinobu Kakigi

  OBJECTIVE: The correlation between the isosorbide-induced decompression effect on the endolymphatic space and plasma osmolality (p-OSM) or plasma arginine vasopressin (p-AVP) was investigated on comparing two different dosages of isosorbide (2.8 and 1.4 g/kg) to elucidate why the decompression effect is delayed with a large dose of isosorbide. MATERIALS AND METHODS: Two experiments were performed using 80 guinea pigs. Experiment 1 was designed to morphologically investigate the sequential influence of the oral intake of 1.4- and 2.8-g/kg doses of isosorbide on the endolymphatic volume. The animals used were 50 guinea pigs (control: 10, experimental: 40). All animals underwent surgical obliteration of the endolymphatic sac of the left ear. One month after the surgery, control animals were sacrificed 3 hours after the intake of distilled water, and experimental animals were sacrificed 3 and 6 hours after the isosorbide intake. All of the left temporal bone served for the quantitative assessment of changes in the endolymphatic space, and the cross-sectional area of the scala media was measured from the mid-modiolar sections of the cochlea.Experiment 2 was designed to investigate changes in p-OSM and p-AVP levels 3 hours after the oral intake of isosorbide. Animals used were 15 guinea pigs (control: 5, experimental: 10). The control group received the oral administration of distilled water (4 ml/kg), and the experimental animals were subdivided into two groups consisting of 10 animals each by the dosage of isosorbide (1.4 or 2.8 g/kg). All animals were sacrificed for the measurement of p-OSM and p-AVP concentrations 3 hours after the intake of water or 70% isosorbide solution. RESULTS: Morphologically, an isosorbide-induced decompression effect was noted in animals with both 1.4- and 2.8-g/kg doses of isosorbide. According to the regression analysis, however, the volumetric decrease of the endolymphatic space was more evident in cases with the small dose (1.4 g/kg) 3 hours after the intake (analysis of covariance [ANCOVA], p < 0.001). Six hours after, the decompression effect was significantly greater in cases with the large dose (2.8 g/kg) (ANCOVA, p < 0.001).Isosorbide intake caused a rise in p-OSM levels dose-dependently. The Cochran-Cox test revealed that the differences in the mean values among control and isosorbide groups were significant (p < 0.01). Regarding the p-AVP level, a significant increase was evident in cases with the large dose (2.8 g/kg) (p < 0.01, Cochran-Cox test), and not in cases with the small dose (1.4 g/kg). CONCLUSION: An isosorbide-induced decompression effect of the endolymphatic space was evident in spite of two different dosages of isosorbide (2.8 and 1.4 g/kg). Three hours after the isosorbide intake, however, the decompression effect was more marked in the group with the small dose (1.4 g/kg). Since significant rises in p-OSM and p-AVP were evident in the group with the large dose, this early rise of p-AVP due to dehydration seems to be the major reason for the delayed decompression effect in cases with a large isosorbide intake.

  Apr. 2017, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 38(4) (4), 599 - 605, English, International magazine

  [Refereed]

  Scientific journal


• 当科における高用量シスプラチンを用いた同時併用化学放射線療法の認容性に関する検討

  米澤 宏一郎, 平山 裕次, 古川 竜也, 森田 成彦, 入谷 啓介, 嘉村 陽子, 太田 陽介, 辻野 佳世子, 副島 俊典, 岩江 信法

  (一社)日本頭頸部癌学会, Oct. 2014, 頭頸部癌, 40(3) (3), 362 - 365, Japanese


• 甲状腺乳頭癌が頸部リンパ節転移巣で未分化転化した3症例

  古川 竜也, 岩江 信法, 平山 裕次, 手島 直則, 松居 秀敏, 米澤 宏一郎

  (NPO)日本気管食道科学会, Jun. 2014, 日本気管食道科学会会報, 65(3) (3), 265 - 271, Japanese


• 術後嚥下機能からみた拡大喉頭亜全摘出術による喉頭温存の切除限界

  岩江 信法, 平山 裕次, 古川 竜也, 森田 成彦, 嘉村 陽子

  日本喉頭科学会, Jun. 2014, 喉頭, 26(1) (1), 22 - 27, Japanese


• 喉頭摘出後早期における口腔伝導用チューブを用いた電気式人工喉頭発声についての検討

  嘉村 陽子, 岩江 信法, 平山 裕次, 米澤 宏一郎, 手島 直則, 松居 秀敏, 古川 竜也, 森田 成彦

  (一社)日本頭頸部癌学会, Apr. 2014, 頭頸部癌, 40(1) (1), 120 - 125, Japanese


• 輪状軟骨弓進展声門癌に対する拡大喉頭亜全摘出術(ESCL-TCHEP)の治療経験

  岩江 信法, 原 聡, 長谷川 稔文, 米澤 宏一郎, 平山 裕次, 古川 竜也, 森田 成彦

  (NPO)日本気管食道科学会, Feb. 2014, 日本気管食道科学会会報, 65(1) (1), 38 - 43, Japanese


• 頭頸部癌化学放射線療法中に発症した特発性食道破裂の1症例

  古川 竜也, 岩江 信法, 平山 裕次, 米澤 宏一郎, 森田 成彦

  (NPO)日本気管食道科学会, Feb. 2014, 日本気管食道科学会会報, 65(1) (1), 44 - 49, Japanese


• 正中下口唇下顎骨舌切断法を用いた舌根部癌照射後救済手術症例

  岩江 信法, 平山 裕次, 手島 直則, 古川 竜也, 森田 成彦, 米澤 宏一郎

  (NPO)日本頭頸部外科学会, Feb. 2014, 頭頸部外科, 23(3) (3), 349 - 355, Japanese


• 当院における下咽頭癌の治療成績の検討

  古川 竜也, 岩江 信法, 平山 裕次, 手島 直則, 副島 俊典, 辻野 佳世子, 太田 陽介

  (一社)日本頭頸部癌学会, Dec. 2013, 頭頸部癌, 39(4) (4), 460 - 465, Japanese


• Myeloid/NK cell acute leukemia with unique blast morphology: De novo or secondary leukemia?

  Shinsaku Imashuku, Naoko Kudo, Park Sungkyu, Masaya Shinbo, Tatsuya Furukawa, Shigenori Iwae

  Oct. 2013, International Journal of Hematology, 98(4) (4), 509 - 511, English, Domestic magazine

  [Refereed]

  Scientific journal


• 膝蓋骨Brown腫瘍を契機に発見された原発性副甲状腺機能亢進症の1例

  手島 直則, 岩江 信法, 平山 裕次, 四宮 弘隆, 古川 竜也

  (NPO)日本気管食道科学会, Jun. 2013, 日本気管食道科学会会報, 64(3) (3), 224 - 230, Japanese


• 頭頸部癌化学放射線療法中に発症した特発性食道破裂の1症例

  古川 竜也, 岩江 信法, 平山 裕次, 手島 直則, 森田 成彦

  (NPO)日本気管食道科学会, Apr. 2013, 日本気管食道科学会会報, 64(2) (2), s87 - s87, Japanese


• 顔面頸部杙創例

  古川 竜也, Ohtsuki Naoki, 松居 秀敏, Nibu Ken-ichi

  耳鼻咽喉科臨床学会, Apr. 2013, 耳鼻咽喉科臨床, 106(4号) (4号), 355 - 358, Japanese

  [Refereed]

  Scientific journal


• Nonsteroidal Anti-inflammatory Drug Treatment for Desmoid Tumor Recurrence after Surgery

  Masanori Teshima, Shigemichi Iwae, Yuji Hirayama, Tatsuya Furukawa

  Nov. 2012, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 147(5) (5), 978 - 979, English, International magazine

  [Refereed]

  Scientific journal


• 頸部郭清術中における副神経の胸鎖乳突筋背側穿通部位に関する検討

  岩江 信法, 平山 裕次, 四宮 弘隆, 手島 直則, 古川 竜也

  (NPO)日本頭頸部外科学会, Jun. 2012, 頭頸部外科, 22(1) (1), 99 - 102, Japanese

• 当科における下咽頭癌化学放射線治療後再発例に対する救済手術の治療成績

  松野祐久, 三根実穂子, 由井光子, 入谷啓介, 蓼原瞬, 下田光, 古川竜也, 手島直則, 四宮弘隆, 丹生健一

  2023, 日本耳鼻咽喉科頭頚部外科学会会報, 126(4) (4)


• 連携、合同診療科vs専門病院、それぞれの強みと弱点 多科合同手術を施行した局所進行甲状腺癌症例の検討

  手島 直則, 寺薗 貴浩, 下田 光, 古川 竜也, 四宮 弘隆, 大月 直樹, 丹生 健一

  (一社)日本内分泌外科学会, May 2021, 日本内分泌外科学会雑誌, 38(Suppl.1) (Suppl.1), S68 - S68, Japanese


• 口腔癌cN(+)における根治的頸部郭清範囲の検討

  手島 直則, 窪田 雄一, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 大月 直樹, 武田 大介, 筧 康正, 長谷川 巧実

  (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 183 - 183, Japanese


• 頭頸部癌治療後の鼻咽腔閉鎖機能評価法としてのBlowing Time RatioとHigh-resolution Manometryの相関

  古川 竜也, 小松 弘和, 高橋 美貴, 上岡 美和, 入谷 啓介, 四宮 弘隆, 蓼原 瞬, 手島 直則, 大月 直樹, 丹生 健一

  (一社)日本頭頸部癌学会, Jul. 2020, 頭頸部癌, 46(2) (2), 203 - 203, Japanese


• 下咽頭癌外側咽頭後リンパ節転移症例の検討

  手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 149 - 149, Japanese


• 中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化

  高橋 美貴, 岩城 忍, 涌井 絵美, 古川 竜也, 四宮 弘隆, 大月 直樹, 清田 尚臣, 宮脇 大輔, 佐々木 良平, 喜多川 浩一, 西村 英輝, 丹生 健一

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese


• 頭頸部外科医からみた嗅神経芽細胞腫の病理診断に関する検討

  古川 竜也, 蓼原 瞬, 井之口 豪, 入谷 啓介, 森田 成彦, 手島 直則, 四宮 弘隆, 森本 浩一, 大月 直樹, 丹生 健一

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 142 - 142, Japanese


• 下咽頭癌外側咽頭後リンパ節転移症例の検討

  手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 149 - 149, Japanese


• 中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化

  高橋 美貴, 岩城 忍, 涌井 絵美, 古川 竜也, 四宮 弘隆, 大月 直樹, 清田 尚臣, 宮脇 大輔, 佐々木 良平, 喜多川 浩一, 西村 英輝, 丹生 健一

  (一社)日本頭頸部癌学会, May 2019, 頭頸部癌, 45(2) (2), 169 - 169, Japanese


• Postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer

  Masanori Teshima, Naoki Otsuki, Hikari Shimoda, Naruhiko Morita, Tatsuya Furukawa, Hitomi Shinomiya, Hirotaka Shinomiya, Nibu Ken―ichi

  Oto-Rhino-Laryngological Society of Japan Inc., 2019, Journal of Otolaryngology of Japan, 122(12) (12), 1561 - 1562, Japanese

  Book review


• 当院における嗅神経芽細胞腫症例の検討

  古川 竜也, 大月 直樹, 四宮 弘隆, 森田 成彦, 井之口 豪, 古閑 紀雄, 清田 尚臣, 佐々木 良平, 甲村 英二, 丹生 健一

  (一社)日本頭頸部癌学会, May 2017, 頭頸部癌, 43(2) (2), 205 - 205, Japanese

• 【最新版 見てわかる! 喉頭・咽頭に対する経口手術】《嚥下障害に対する手術》 内視鏡下輪状咽頭筋切断術

  古川 竜也

  (株)医学書院, Jun. 2023, Japanese


• 今日の治療指針 : 私はこう治療している

  古川 竜也

  Contributor, 嚥下障害, 医学書院, Jan. 2023, Japanese, ISBN: 9784260050357


• 【内科医が知っておきたい摂食・嚥下障害-嚥下障害をきたす疾患背景とさまざまな対応・治療法】嚥下障害の疫学と学会指針 嚥下障害の疫学・現状

  古川 竜也

  (株)文光堂, Jul. 2022, Japanese


• 耳鼻咽喉科頭頸部外科領域のリハビリテーション医学・医療テキスト

  古川竜也, 丹生健一

  Contributor, 頸部郭清術後のリハビリテーション診療, 日本リハビリテーション医学教育推進機構, Jun. 2022, Japanese, ISBN: 9784991177613


• 【結果の読み方がよくわかる! 耳鼻咽喉科検査ガイド】嚥下障害の検査 高解像度嚥下圧検査

  古川 竜也

  (株)医学書院, Apr. 2022, Japanese


• 今日の治療指針 : 私はこう治療している

  古川 竜也

  Contributor, 摂食・嚥下障害患者のリハビリテーション, 医学書院, Jan. 2022, Japanese, ISBN: 9784260047760


• 【舌がん・口腔がん治療の最前線】支持療法 嚥下障害への対応戦略 術前評価から誤嚥防止手術まで

  古川 竜也, 丹生 健一

  (株)医学書院, Dec. 2019, Japanese


• 【嚥下障害を診る!-プロに学ぶ実践スキル】病態と診断 超高齢社会における嚥下トリアージ

  上岡 美和, 古川 竜也, 丹生 健一

  (株)医学書院, Sep. 2019, Japanese


• 【ここが知りたい! 高齢化時代の頭頸部がん診療】 術後摂食嚥下障害への対応

  FURUKAWA TATSUYA, NIBU KENICHI

  (株)医学書院, Jul. 2017, Japanese


• がんの理学療法 (理学療法MOOK 21)

  古川竜也, 丹生健一

  Contributor, 頭頸部がんの病態と治療, 三輪書店, May 2017, Japanese, ISBN: 4895906019


• 【急性期呼吸管理のトレンドをチェック!プラクティカル体位呼吸療法】非侵襲的呼吸管理(NIRS)の応用

  尾崎 孝平, 浅羽 穣二, 中川 夏季, 古川 竜也

  (株)メディカ出版, Jun. 2009, Japanese, ISBN: 9784840427760

• 連携、合同診療科vs専門病院、それぞれの強みと弱点 多科合同手術を施行した局所進行甲状腺癌症例の検討

  手島 直則, 寺薗 貴浩, 下田 光, 古川 竜也, 四宮 弘隆, 大月 直樹, 丹生 健一

  日本内分泌外科学会雑誌, May 2021, Japanese, (一社)日本内分泌外科学会


• 頭頸部癌治療後の鼻咽腔閉鎖機能評価法としてのBlowing Time RatioとHigh-resolution Manometryの相関

  古川 竜也, 小松 弘和, 高橋 美貴, 上岡 美和, 入谷 啓介, 四宮 弘隆, 蓼原 瞬, 手島 直則, 大月 直樹, 丹生 健一

  頭頸部癌, Jul. 2020, Japanese, (一社)日本頭頸部癌学会


• 口腔癌cN(+)における根治的頸部郭清範囲の検討

  手島 直則, 窪田 雄一, 入谷 啓介, 蓼原 瞬, 古川 竜也, 四宮 弘隆, 大月 直樹, 武田 大介, 筧 康正, 長谷川 巧実

  頭頸部癌, Jul. 2020, Japanese, (一社)日本頭頸部癌学会


• 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討

  小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一

  頭頸部癌, Jul. 2020, Japanese, (一社)日本頭頸部癌学会


• 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討

  高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣

  頭頸部癌, Jul. 2020, Japanese, (一社)日本頭頸部癌学会


• 頭頸部外科医からみた嗅神経芽細胞腫の病理診断に関する検討

  古川 竜也, 蓼原 瞬, 井之口 豪, 入谷 啓介, 森田 成彦, 手島 直則, 四宮 弘隆, 森本 浩一, 大月 直樹, 丹生 健一

  頭頸部癌, May 2019, Japanese, (一社)日本頭頸部癌学会


• 下咽頭癌外側咽頭後リンパ節転移症例の検討

  手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一

  頭頸部癌, May 2019, Japanese, (一社)日本頭頸部癌学会


• 中咽頭癌に対する化学放射線療法による摂食・嚥下に関するQOLの変化

  高橋 美貴, 岩城 忍, 涌井 絵美, 古川 竜也, 四宮 弘隆, 大月 直樹, 清田 尚臣, 宮脇 大輔, 佐々木 良平, 喜多川 浩一, 西村 英輝, 丹生 健一

  頭頸部癌, May 2019, Japanese, (一社)日本頭頸部癌学会


• 下咽頭癌外側咽頭後リンパ節転移症例の検討

  手島 直則, 古川 竜也, 森田 成彦, 四宮 弘隆, 森本 浩一, 大月 直樹, 清田 尚臣, 佐々木 良平, 丹生 健一

  頭頸部癌, May 2019, Japanese, (一社)日本頭頸部癌学会


• 当科における内視鏡下輪状咽頭筋切断術の経験

  FURUKAWA TATSUYA, MORIMOTO KOICHI, 藤尾 久美, 小松 弘和, 茂木 千聡, 由井 光子, 下田 光, SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI, 岩城 忍, 高橋 美貴, 涌井 絵美, 上岡 美和

  第42回日本嚥下医学会, Mar. 2019, Japanese, 久留米, Domestic conference

  Oral presentation


• 施行しHRMで評価した1例

  FURUKAWA TATSUYA, TESHIMA MASANORI, UEHARA NATSUMI, 森本 浩一, 藤尾 久美, 小松 弘和, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI

  第29回 日本頭頸部外科学会, Jan. 2019, Japanese, 仙台, Domestic conference

  Oral presentation


• 外耳道癌術後の嚥下障害に段階的に嚥下機能改善手術を

  FURUKAWA TATSUYA, TESHIMA MASANORI, UEHARA NATSUMI, 森本 浩一, 藤尾 久美, 小松 弘和, SHINOMIYA HIROTAKA, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI

  第29回 日本頭頸部外科学会, Jan. 2019, Japanese, 仙台, Domestic conference

  Oral presentation


• 片側反回神経麻痺を伴う甲状腺乳頭癌症例の検討

  TESHIMA MASANORI, OTSUKI NAOKI, MORITA NARUHIKO, FURUKAWA TATSUYA, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, NIBU KENICHI

  第５１回日本甲状腺外科学会, Oct. 2018, Japanese, 横浜, Domestic conference

  Oral presentation


• 神経筋疾患に対する声門閉鎖術実施における周術期の問題点

  FURUKAWA TATSUYA, 小松 弘和, 藤尾 久美, 茂木 千聡, OTSUKI NAOKI, KAKIGI AKINOBU, NIBU KENICHI

  第1４回 日本神経筋疾患摂食・嚥下・栄養研究会, Oct. 2018, Japanese, 名古屋, Domestic conference

  Oral presentation


• 当科における内視鏡下輪状咽頭筋切断術の経験

  FURUKAWA TATSUYA, MORIMOTO KOICHI, 小松 弘和, FUJIO HISAMI, 茂木 千聡, UEHARA NATSUMI, SHINOMIYA HIROTAKA, OTSUKI NAOKI, NIBU KENICHI, 岩城 忍, 高橋 美貴, 上岡 美和, 千年 俊一

  第189回日耳鼻兵庫県地方部会, Jul. 2018, Japanese, 神戸, Domestic conference

  Oral presentation


• 頭頸部癌治療後の嚥下障害に対して施行した声門閉鎖術

  FURUKAWA TATSUYA, 小松 弘和, 藤尾 久美, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORITA NARUHIKO, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI

  頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference

  Oral presentation


• 頭頸部癌治療後の嚥下障害に対して

  FURUKAWA TATSUYA, 小松 弘和, FUJIO HISAMI, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI

  第42回日本頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• 声門閉鎖術を施行した6例

  FURUKAWA TATSUYA, 小松 弘和, FUJIO HISAMI, TESHIMA MASANORI, SHINOMIYA HIROTAKA, MORIMOTO KOICHI, OTSUKI NAOKI, NIBU KENICHI

  第42回日本頭頸部癌学会, Jun. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• 当科における声門閉鎖術

  小松 弘和, Fujio Kumi, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi

  第30回日本喉頭科学会, Mar. 2018, Japanese, 日本喉頭科学会, 高知, Domestic conference

  Poster presentation


• 当院における食道癌術後摂食嚥下障害の検討

  小松 弘和, Fujio Kumi, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi

  第41回日本嚥下医学会, Feb. 2018, Japanese, 日本嚥下医学会, 仙台, Domestic conference

  Oral presentation


• 進行下咽頭癌手術例における外側咽頭後リンパ節郭清の意義について

  Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi

  第28回日本頭頸部外科学会, Jan. 2018, Japanese, 日本頭頸部外科学会, 宇都宮, Domestic conference

  Oral presentation


• 当科における声門閉鎖術

  小松 弘和, Fujio Kumi, 鶴田 賀之, Shinomiya Hirotaka, Morimoto Koichi, Ohtsuki Naoki, Nibu Ken-ichi

  日耳鼻地方部会, Jul. 2017, Japanese, 神戸, Domestic conference

  Oral presentation


• 当科における 頭頸部腺様嚢胞癌の検討

  Shinomiya Hirotaka, Ohtsuki Naoki, Nibu Ken-ichi

  第41回日本頭頸部癌学会, Jun. 2017, Japanese, 日本頭頸部癌学会, 京都, Domestic conference

  Oral presentation


• 当院における 嗅神経芽細胞腫の検討

  Ohtsuki Naoki, Shinomiya Hirotaka, Inokuchi Gou, Kokan Norio, Kiyota Naomi, Sasaki Ryohei, Kohmura Eiji, Nibu Ken-ichi

  第41回日本頭頸部癌学会, Jun. 2017, Japanese, 京都, Domestic conference

  Oral presentation