Research activity information

• Otologic Surgery Improved Quality of Life of the Patients: A Multicenter Study in Japan.

  Makoto Hosoya, Akira Ganaha, Hidekane Yoshimura, Yuka Morita, Kuniyuki Takahashi, Tatsuya Yamagishi, Nozomu Matsumoto, Takeshi Fujita, Shinya Miuchi, Ryo Akai, Kyoko Shirai, Akinori Kashio, Katsumi Doi, Noriko Ohira, Tsukasa Ito, Takanari Goto, Masahiro Takahashi, Mariko Takahashi, Masahiro Takahashi, Manabu Komori, Yohei Honkura, Harukazu Hiraumi, Yusuke Ayani, Masahiro Okada, Norio Yamamoto, Yosuke Tona, Tetsuo Ikezono, Shin-Ichi Usami, Shin-Ichi Haginomori, Takashi Nakagawa, Naoki Oishi, Tetsuya Tono, Seiji Kakehata, Hiromi Kojima, Sho Kanzaki

  OBJECTIVE: Otological diseases impair patients' physical, mental, and social quality of life. Surgical intervention against otologic diseases can improve the deterioration of the patient's quality of life and the recovery of hearing loss; however, no large-scale multicenter studies in Japan have investigated patients' quality of life after otologic surgery. To conduct a prospective investigation on the quality of life of patients who underwent otologic surgery. STUDY DESIGN: Case-control study. SETTING: A multicenter study involving 21 hospitals in Japan. PATIENTS: We enrolled 199 patients with cholesteatoma, 137 patients with chronic otitis media, 72 patients with otosclerosis, 126 patients before cochlear implantations, 12 patients with middle ear malformation, and 27 patients with other otologic diseases. INTERVENTIONS: We compared the impairment in patients' quality of life between different otologic diseases and examined the effects of surgical intervention using generic and disease-specific quality-of-life questionnaires. MAIN OUTCOME MEASURES: Improvement of the quality of life of the patients measured with general or disease-specific questionnaires. RESULTS: Our results revealed that the patients' preoperative quality of life was lower than that of the control group. Patients who underwent cochlear implantation had a significantly lower quality of life compared with other groups. The results also revealed that surgical intervention could improve postoperative quality of life. In addition, the study revealed the characteristic features of changes in the quality of life in each otologic disease group. CONCLUSIONS: These findings will be useful for patients when deciding on surgical intervention. It would also benefit otologic surgeons when explaining surgical indications or recommending surgical interventions.

  Jun. 2026, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 47(5) (5), 734 - 743, English, International magazine

  Scientific journal


• Multicenter Natural History Study and Long-Term Cochlear Implant Outcomes in Usher Syndrome Subtypes.

  Paul Emmerich Krumpoeck, Anselm Joseph Gadenstaetter, Natsumi Uehara, Takeshi Fujita, Nadia Giarbini, Maximilian Pawloff, Markus Ritter, Anna Landegger, Thomas Parzefall, Dominik Riss, Wolf-Dieter Baumgartner, Wolfgang Gstoettner, Christoph Arnoldner, Lukas David Landegger

  OBJECTIVES: Usher syndrome (USH) is an inherited disorder that causes bilateral sensorineural hearing loss (SNHL), retinitis pigmentosa, and vestibular defects. It represents the most common cause of combined deaf-blindness worldwide. Mutations in the nine known underlying genes are categorized into three types: USH type 1 has the earliest, most severe onset, while the much more common USH type 2 is comparatively mild with delayed onset and moderate symptoms. USH type 3 is very rare and exhibits variable clinical manifestations. The current standard of care for SNHL in USH is comprised of conventional hearing aids and/or cochlear implantation depending on the severity of symptoms. However, existing studies on treatment outcomes generally have rather short follow-up durations from a single institution and rarely distinguish between the individual USH subtypes. DESIGN: This retrospective multicenter cohort study analyzed 655 audiograms of 33 patients (66 ears) with genetically confirmed USH. Patient-specific characteristics and treatments were correlated with pure-tone average thresholds and speech perception performance over a mean (SD) of 7 yrs and 10 mo (9 yrs and 11 mo) overall and 8 yrs and 2 mo (6 yrs and 3 mo) after cochlear implantation. RESULTS: Conventional hearing aids improved thresholds on average (SD) by 20.1 (10.9) dB HL regardless of age, but aided hearing still deteriorated concurrently with the natural progression of SNHL. In patients with severe-to-profound SNHL or complete deafness, cochlear implantation rescued hearing to average thresholds of 37.9 (7.0) dB HL 1 yr post-implantation, 37.3 (10.3) dB HL after 2 years, and 27.5 (7.1) dB HL after 15 to 20 yrs. Every single patient who received an implant benefited from it, irrespective of the age at implantation or the causative USH mutation. CONCLUSIONS: With new gene therapies for USH in development, the findings reported here can serve as a benchmark for the comparison of novel treatments with the current clinical standard of care around the world. Larger-scale studies with more consistent monitoring of hearing and speech perception ability, as well as more extensive genetic testing, could further elucidate the benefits of current treatments for different (sub-)types of USH.

  Apr. 2026, Ear and hearing, English, International magazine

  Scientific journal


• Longitudinal Correlation of Frequency-to-Place Mismatch and Postoperative Speech Perception Outcomes in Cochlear Implant Recipients: Monosyllable, Consonant, Word, and Sentence.

  Toshihito Sahara, Yujiro Hoshi, Anjin Mori, Hajime Koyama, Yasuhiro Osaki, Waki Nakajima, Takeshi Fujita, Akinori Kashio, Katsumi Doi

  Background/Objectives: Frequency-to-place mismatch between cochlear implant (CI) electrodes and cochlear tonotopy has been suggested to affect postoperative speech perception. This study aimed to examine the associations between frequency-to-place mismatch and speech perception outcomes across multiple linguistic levels in patients with CI and to assess how these associations change over time using postoperative computed tomography. Methods: This retrospective cohort study included 44 postlingually deafened adults who underwent unilateral cochlear implantation with a Flex28 electrode by a single surgeon at a tertiary care hospital. Speech perception was assessed using CI-2004, a Japanese speech perception test consisting of monosyllables, consonants, words, and sentences, in quiet settings at 3, 6, and 12 months after CI activation. Partial correlation analyses between frequency-to-place mismatch and postoperative speech perception scores were performed in 35 of the 44 patients, controlling for age and mean preoperative pure-tone thresholds. Results: Negative associations were observed between frequency-to-place mismatch and CI-2004 scores, particularly for monosyllable and consonant perception in uncorrected analyses. After correction for multiple comparisons, only consonant perception at 3 months after CI activation remained significant (r = -0.52, p = 0.002). Similar patterns were observed for other speech measures and at later time points, although these did not remain significant after correction. Conclusions: Frequency-to-place mismatch was associated with postoperative speech perception outcomes, particularly those involving phoneme-level recognition. After correction for multiple comparisons, only consonant perception at 3 months after CI activation remained significant.

  Apr. 2026, Audiology research, 16(2) (2), English, International magazine

  Scientific journal


• Influences of Cheek Support on Sucking Pressure During Bottle Feeding in Infants: A Pilot Study.

  Takeshi Komatsu, Tatsuya Furukawa, Daisuke Kobayashi, Sota Iwatani, Seiji Yoshimoto, Toshihiko Yamashita, Sayaka Katsunuma, Masahide Otsu, Takeshi Fujita, Ken-Ichi Nibu

  Effective sucking is important for shortening hospital stays in newborn infants. Several studies have demonstrated that oral support can improve sucking efficiency. However, the effects of oral support on sucking pressure have not been thoroughly investigated. In our previous study, we reported the equipment configuration and analysis method of sucking pressure. That method of measuring sucking pressure was applied to cheek support. In this study, four newborn infants with low birth weight, congenital diaphragmatic hernia, or multicystic encephalomalacia were enrolled. Their sucking pressures were measured during bottle feeding, both with and without cheek support. In all cases, cheek support increased sucking pressure. However, changes in intake volume and the number of sucking bursts, individual sucks did not show a consistent pattern. Our study indicates a possible association between cheek support and sucking pressure during oral feeding in newborn infants. Larger studies are needed to confirm this effect.

  Feb. 2026, The Kobe journal of medical sciences, 71(4) (4), E149-E153, English, Domestic magazine

  Scientific journal


• 術前塞栓術やエネルギーデバイスによる焼灼を行わずに経外耳道的内視鏡下耳科手術(TEES)で摘出し得たグロムス腫瘍症例

  小西池 佑一, 藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Feb. 2026, Otology Japan, 36(1) (1), 42 - 48, Japanese


• Surgical instrument segmentation and classification in transcanal endoscopic ear surgery video using Segment Anything Model 2.

  Ryunosuke Ueno, Takeshi Fujita, Kazuhiro Matsui, Keita Atsuumi, Natsumi Uehara, Toshihiko Yamashita, Hiroaki Hirai, Toshikazu Kawai, Hisashi Suzuki, Atsushi Nishikawa

  BACKGROUND: Accurate automatic recognition of surgical instruments is important for enhancing the safety and efficiency of transcanal endoscopic ear surgery (TEES). Segment Anything Model 2 (SAM 2) is a state-of-the-art artificial intelligence (AI) model featuring "zero-shot segmentation", which allows it to identify objects without extensive training data. The purpose of this study was to be the first to apply SAM 2 to TEES videos to evaluate its performance in segmenting and classifying surgical instruments. METHODS: From videos of three clinical TEES cases (tympanoplasty), we created a 684-frame evaluation video that simulated the sequential use of four types of surgical instruments: cupped forceps, pick, alligator forceps, and circular knife. SAM 2 was instructed to identify the instruments using only 12 reference images. Performance was quantitatively evaluated using four metrics-Precision, Recall, dice similarity coefficient (DSC), and intersection over union (IoU)-as well as a confusion matrix to assess frame-level classification accuracy by comparing the model's output to manually created ground-truth annotations. RESULTS: For segmentation without classification, SAM 2 demonstrated excellent performance, with a mean Precision of 0.98, a mean Recall of 0.89, a mean DSC of 0.93, and a mean IoU of 0.87. When classifying the four specific instrument types, performance varied, with mean Precision ranging from 0.68 to 0.98, mean Recall from 0.79 to 0.86, mean DSC from 0.62 to 0.89, and mean IoU from 0.58 to 0.84. Notably, false-positive detections in non-instrument regions were extremely rare. A trend of lower classification accuracy was observed for articulating instruments with moving parts (cupped forceps and alligator forceps). CONCLUSIONS: This study demonstrated that SAM 2 can accurately identify surgical instruments in TEES videos without the need to prepare large, costly training datasets. This zero-shot segmentation characteristic significantly lowers the barrier to clinical implementation of AI, suggesting it is a promising foundational technology for future surgical navigation and robotic automation. Key future challenges include improving classification accuracy for articulating instruments and accelerating processing speed for practical, real-time use.

  Dec. 2025, Quantitative imaging in medicine and surgery, 15(12) (12), 12386 - 12397, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Establishing a comprehensive national auditory implant registry in Japan: Trends and demographics from the first two years (2023–2024)

  Ayu Akazawa, Takeshi Fujita, Kensuke Uraguchi, Megumi Kitayama, Taku Ito, Yasuhiro Osaki, Kyoko Shirai, Haruo Yoshida, Norio Yamamoto, Katsumi Doi, Satoshi Iwasaki, Naoki Oishi

  Dec. 2025, Auris Nasus Larynx, 52(6) (6), 679 - 686, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hearing Preservation and Complications of the Middle Cranial Fossa Approach for Otolaryngological Diseases: Twelve-Year Single-Center Experience.

  Toshihito Sahara, Takeshi Fujita, Yujiro Hoshi, Hajime Koyama, Anjin Mori, Yasuhiro Osaki, Akinori Kashio, Yasuhiro Sanada, Katsumi Doi

  Objectives: The middle cranial fossa (MCF) approach is valued for preserving hearing while accessing the internal auditory canal (IAC), petrous apex, inner ear, and related structures. This study evaluated its clinical outcomes across otolaryngological diseases, focusing on postoperative complications, hearing preservation, and the effect of IAC manipulation on auditory function. Methods: We retrospectively analyzed 35 patients who underwent MCF otologic surgery at a single center over twelve years. We calculated the proportion of MCF cases among all otologic surgeries and assessed postoperative complications and hearing changes (bone conduction thresholds). Outcomes were compared between patients with and without IAC manipulation. Results: MCF procedures comprised 1.4% of all otologic surgeries. Petrous bone cholesteatoma was the leading indication (15 cases). Intracranial complications occurred in 4 patients (11.4%): seizures, epidural abscess, and cerebral infarction. Facial nerve paralysis occurred in 3 (10.7%) patients without any cerebrospinal fluid leaks. In patients without IAC manipulation, hearing functions were preserved (22.3 ± 7.8 dB HL pre- vs. 25.7 ± 9.5 dB HL postoperatively), whereas those with IAC manipulation showed significantly greater deterioration. Conclusions: The middle cranial fossa approach, though technically demanding and infrequently used, offers a safe and effective option across various otolaryngological diseases. This approach achieved favorable hearing preservation with a low complication rate, particularly when intradural manipulation of the IAC was not required.

  Nov. 2025, Journal of clinical medicine, 14(21) (21), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Clinical characteristics and hearing impairment in carriers of the m.3243 A > G variant

  Natsumi Uehara, Takeshi Fujita, Keiichiro Uehara, Hikari Shimoda, Daisuke Yamashita, Jun Yokoi, Sayaka Katsunuma, Akinobu Kakigi, Ken-ichi Nibu

  Oct. 2025, Journal of Human Genetics, 71(3) (3), 145 - 149, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 聴神経腫瘍の手術前後の前庭機能に関する検討

  横井 純, 藤田 岳, 山下 俊彦, 上原 奈津美, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2025, Equilibrium Research, 84(5) (5), 466 - 466, Japanese


• 当院におけるアッシャー症候群の平衡機能の検討

  宮内 麻衣, 上原 奈津美, 横井 純, 山下 俊彦, 藤田 岳, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2025, Equilibrium Research, 84(5) (5), 472 - 472, Japanese


• Melody recognition and speech discrimination in post-lingual Japanese cochlear implant users

  Reham Salah, Mari Washimi, Shinobu Iwaki, Jun Yokoi, Natsumi Uehara, Takeshi Fujita, Reham Gamal, Mohamed El-Badry, Akinobu Kakigi, Ken-ichi Nibu, Rafeek Mohamed Abdelkader

  Sep. 2025, EGYPTIAN JOURNAL OF OTOLARYNGOLOGY, 41(1) (1), English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 高音急墜型感音難聴患者における臨床像および聴覚補償の検討

  上原 奈津美, 岩城 忍, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2025, Audiology Japan, 68(5) (5), 415 - 415, Japanese


• 高齢者における人工内耳の装用効果(第2報)

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2025, Audiology Japan, 68(5) (5), 465 - 465, Japanese


• Intracochlear Imaging Using IVUS and OFDI: A Cadaveric Feasibility Study

  Ayu Akazawa, Takeshi Fujita, Jun Yokoi, Natsumi Uehara, Mie Kubo, Akinobu Kakigi, Ken‐ichi Nibu

  OBJECTIVE: This study evaluates the feasibility of optical frequency domain imaging (OFDI) and intravascular ultrasound (IVUS) for intracochlear imaging in human cadaveric specimens. We compare their resolution, depth penetration, and ability to identify key cochlear structures and pathological conditions. METHODS: Human cadaveric temporal bones were prepared, and OFDI and IVUS probes were inserted through the round window into the scala tympani. OFDI imaging was performed using the LUNAWAVE system (Terumo, Tokyo, Japan), while IVUS imaging was conducted using the VISICUBE system (Terumo, Tokyo, Japan) with 60 and 40 MHz probes. The probe tips were trimmed to optimize insertion and imaging. Imaging results were compared with histological sections. RESULTS: OFDI provided high-resolution visualization of the cochlear basal turn, allowing clear identification of the basilar membrane, Reissner's membrane, scala media, and the organ of Corti. IVUS exhibited lower resolution than OFDI but allowed for deeper tissue penetration. The 60 MHz IVUS probe provided higher resolution than the 40 MHz probe, while the 40 MHz probe offered a wider field of view due to greater penetration depth and lower attenuation. Both OFDI and IVUS successfully detected basilar membrane disruptions, a known complication in cochlear implant surgery. CONCLUSION: OFDI and IVUS demonstrated feasibility for intracochlear imaging, with OFDI offering superior resolution and IVUS providing greater penetration. This is the first study to apply IVUS for intracochlear imaging, supporting its potential role in intraoperative monitoring and cochlear pathology assessment. LEVEL OF EVIDENCE: N/A.

  Aug. 2025, Laryngoscope Investigative Otolaryngology, 10(4) (4), e70224, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Robotic and computer-assisted techniques in ear surgery

  Takeshi Fujita, Taku Ito, Masaya Uchida, Hajime Koyama, Masahiro Takahashi, Takara Nakazawa, Takashi Fujiwara, Nozomu Matsumoto, Tadao Yoshida, Naohiro Yoshida, Seiji Kakehata, Manabu Komori, Naohito Hato

  Robotic and computer-assisted systems for ear surgery are receiving growing attention as tools to overcome the challenges intrinsic to the delicate, restricted operative field of the middle and inner ear. This review highlights recent advances in robotic platforms, clinical outcomes, and emerging technologies such as augmented reality (AR), virtual reality (VR), and artificial intelligence (AI). Multiple groups worldwide have introduced robotic devices that aid or automate tasks like mastoid drilling, stapes footplate fenestration, and cochlear implant (CI) electrode insertion. Seminal studies involving systems such as HEARO, iotaSoft, and RobOtol reveal sub-millimeter accuracy and minimized trauma during CI, suggesting the potential to reduce postoperative complications and improve hearing preservation. Although these technologies have progressed from proof-of-concept prototypes to early clinical usage, significant barriers remain before they become routine. Cost is a key concern, given the relatively small patient population for otologic procedures compared to other surgical fields. Regulatory pathways also require strict safety validations, particularly for semi-autonomous or fully autonomous functions. Nevertheless, FDA and European CE approvals for certain robotic systems illustrate their growing feasibility. Meanwhile, AR- and VR-based navigation is improving intraoperative visualization by overlaying critical structures such as the facial nerve onto the surgeon's field, while AI-driven algorithms for instrument tracking and real-time monitoring offer further enhancements in safety and precision. In addition, simulation-based training in VR environments can accelerate surgical expertise and reduce learning curves. Larger-scale clinical trials that directly compare robotic and conventional approaches are still needed to quantify benefits related to complication rates, operative times, and long-term auditory outcomes. Ongoing innovations in software integration and miniaturized hardware are likely to broaden the range of feasible robotic tasks within the ear's narrow anatomical boundaries.

  Aug. 2025, Auris Nasus Larynx, 52(4) (4), 496 - 501, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Current treatment strategies for external auditory canal cancer.

  Hirotaka Shinomiya, Takeshi Fujita, Ken-Ichi Nibu

  Jul. 2025, Japanese journal of clinical oncology, 55(7) (7), 699 - 706, English, International magazine

  Scientific journal


• Three-dimensional terahertz near-field imaging evaluation of cochlea

  Luwei Zheng, Haidong Chen, Takeshi Fujita, Akinobu Kakigi, Nicole Allen, Hironaru Murakami, Masayoshi Tonouchi, Kazunori Serita

  Apr. 2025, Optica, 12(4) (4), 437 - 445, English

  Scientific journal


• OTOPLANを用いたFLEXsoft人工内耳電極の検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2025, 日本耳鼻咽喉科頭頸部外科学会会報, 128(4) (4), 690 - 690, Japanese


• Melatonin mitigates UV-induced tumorigenesis and suppresses hearing function deterioration in Xpa-deficient mice.

  Mariko Tsujimoto, Takeshi Fujita, Tatsuya Furukawa, Yaeno Arima, Ken-Ichi Nibu, Chikako Nishigori

  BACKGROUND: Xeroderma pigmentosum (XP) is caused by impaired DNA repair of UV-induced dipyrimidine-photoproducts. XP cells also show impaired repair/removal of ROS or oxidative DNA lesions caused by UV or 4-nitroquinolline 1-oxide (4NQO). Gene profiling indicated that inflammatory response-related genes are significantly upregulated after UV exposure in XP-A model mice. OBJECTIVE: Since XP cells are in the state of oxidative stress and inflammation, we aimed to search for therapeutic agents from anti-oxidants/anti-inflammatory drugs, that potentially improve XP symptoms. METHODS: Several antioxidants were examined for reducing 4NQO-induced oxidative cytotoxicity or UV-induced oxidative DNA damage in XP-A cells. Among them, we focused on melatonin and evaluated its improving effect for Xpa-deficient MEF on UV-induced cytotoxicity and ROS production, and for Xpa-deficient mice on UV-induced skin tumorigenesis and auditory brainstem responses as one of the neurological symptoms. RESULTS: Melatonin and nicotinamide attenuated 4NQO-induced oxidative cytotoxicity. UV-induced intracellular ROS production and cytotoxicity were improved by melatonin for Xpa-deficient MEF. Finally, the administration of melatonin mitigated UV-induced skin inflammation and tumorigenesis and suppressed hearing deterioration in Xpa-deficient mice. CONCLUSION: Our results show that melatonin could alleviate XP symptoms through its anti-inflammatory and antioxidant properties.

  Jan. 2025, Journal of dermatological science, 117(3) (3), 81 - 87, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Robot for Transcanal Endoscopic Ear Surgery with Gimbal-based Rotational Linkage and Linear Guide Rail Mechanisms

  Takeshi FUJITA, Kenta YOKOYAMA, Toshikazu KAWAI, Natsumi UEHARA, Toshihiko YAMASHITA, Takefumi KAMAKURA, Yu MATSUMOTO, Kunio MIZUTARI, Akinobu KAKIGI, Ken-ichi NIBU, Hisashi SUZUKI, Atsushi NISHIKAWA

  2025, Advanced Biomedical Engineering, 14, 146 - 154, English

  Scientific journal


• Cochlear signal intensity changes in vestibular schwannoma: a balanced fast field-echo MRI study.

  Hiroko Takeda, Takeshi Fujita, Tomonori Kanda, Yoichi Uozumi, Natsumi Uehara, Jun Yokoi, Akinobu Kakigi, Takashi Sasayama, Ken-Ichi Nibu

  INTRODUCTION: Vestibular schwannoma (VS) is a benign tumor associated with cochlear degeneration and sensorineural hearing loss (SNHL). This study aimed to evaluate cochlear signal intensity in VS patients using balanced fast field-echo (bFFE) magnetic resonance imaging (MRI) and to explore its relationship with tumor size, hearing loss, and postoperative changes. METHODS: A retrospective analysis was conducted on 165 VS patients and 30 SNHL control patients who underwent bFFE MRI at Kobe University Hospital from 2008 to 2019. Cochlear signal intensity was measured bilaterally using regions of interest (ROIs), and signal intensity ratios (affected/normal) were calculated. Statistical analyses included linear regression and ANOVA to evaluate correlations with hearing levels, tumor size, and postoperative changes. RESULTS: VS patients exhibited significantly lower cochlear signal intensity ratios on the affected side compared to controls (75.3% vs. 100%, p < 0.0001). Correlations between cochlear signal intensity ratios and hearing levels were significant in Koos grade I tumors but not in higher-grade tumors. Tumor size was negatively correlated with cochlear signal intensity ratios in Koos grade II-IV tumors. Postoperatively, signal intensity normalized within 1-2 years, irrespective of hearing preservation. DISCUSSION: Decreased cochlear signal intensity in VS patients may indicate protein concentration changes due to tumor secretions. bFFE MRI effectively captures these changes, providing insights into cochlear physiology and tumor impact. CONCLUSION: bFFE MRI is a reliable tool for assessing cochlear signal intensity in VS patients, offering potential for improved tumor evaluation, surgical planning, and postoperative monitoring.

  2025, Frontiers in neurology, 16, 1549869 - 1549869, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Transcanal Endoscopic Ear Surgery for Pediatric Bilateral Congenital Cholesteatoma: A Report of Two Cases.

  Takashi Ueda, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Mitsuko Yui, Ayu Akazawa, Toshihiko Yamashita, Yukako Goto, Akinobu Kakigi, Ken-Ichi Nibu

  Bilateral congenital cholesteatoma (BCC) is rare among congenital cholesteatoma (CC) cases, and bilateral surgery poses a significant psychophysical burden on pediatric patients. Here, we present 2 pediatric cases of BCC that were successfully managed using simultaneous bilateral transcanal endoscopic ear surgery (TEES). The surgical approach provided clear visualization of the middle ear structures, enabling successful cholesteatoma removal with minimal invasiveness and a short operative time. In both cases, follow-up computed tomography showed no recurrence, and pure-tone audiometry results demonstrated good outcomes. Simultaneous bilateral TEES can be a viable option for pediatric BCC, as it reduces patient burden due to its less invasive procedure and short operative time.

  Nov. 2024, The journal of international advanced otology, 20(6) (6), 540 - 542, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Results of a Questionnaire Survey on Childbirth and Childcare for Young Members and Core Facilities of The Japanese Society of Otorhinolaryngology-Head and Neck Surgery-Report of the Working Group on Work Style Reform-

  藤田岳, 藤田岳, 藤田岳, 森田由香, 森田由香, 森田由香, 松延毅, 松延毅, 丸山裕美子, 丸山裕美子, 櫻井結華, 櫻井結華, 吉川衛, 吉川衛, 角南貴司子, 角南貴司子, 小林一女, 小林一女, 小林一女, 丹生健一, 丹生健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Oct. 2024, 日本耳鼻咽喉科頭頚部外科学会会報, 127(10) (10), 1064 - 1071, Japanese


• -Results of a Questionnaire Survey on Work Style Reform-Report from the Working Group on Work Style Reform of the Japanese Society of Otorhinolaryngology-Head and Neck Surgery

  櫻井結華, 櫻井結華, 藤田岳, 藤田岳, 森田由香, 森田由香, 吉川衛, 吉川衛, 角南貴司子, 角南貴司子, 小林一女, 小林一女, 丹生健一, 丹生健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Sep. 2024, 日本耳鼻咽喉科頭頚部外科学会会報, 127(9) (9), 994 - 1003, Japanese


• 好酸球性副鼻腔炎に対するバイオ製剤治療による中耳炎への効果の検討

  上原 奈津美, 由井 光子, 藤田 岳, 井之口 豪, 柿木 章伸, 丹生 健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 4回, 216 - 216, Japanese


• Expression of EGFR and p16 in Squamous Cell Carcinoma of External Auditory Canal.

  Yasuyuki Kajimoto, Hirotaka Shinomiya, Natsumi Uehara, Masanori Teshima, Takeshi Fujita, Akinobu Kakigi, Yoshinori Imamura, Naomi Kiyota, Daisuke Miyawaki, Ryohei Sasaki, Hidehito Kimura, Ken-Ichi Nibu

  The expression of EGFR and p16 in the external auditory canal squamous cell carcinoma (EACSCC) and their impacts on oncological outcomes were not well studied. Seventeen-one consecutive patients who were treated for EACSCC at Kobe University Hospital from 1995 to 2018 were enrolled in this study. The expression of EGFR, and p16 were evaluated and their impacts on oncological outcomes were statistically analyzed. Positive expression of EGFR was observed in 62 patients (87%). Strong positive expression of p16 were observed in 18 patients (32.4%), and weakly positive expression in 30 patients (42.3%), respectively. While the number of the patients with negative EGFR expression were limited, all the surgically treated patients with negative EGFR expression have been alive without disease. In the patients with T3 & T4a EACSCC, prognosis of the patients with positive p16 expression EACSCC tended to be better than those with negative p16 expression. These results suggest the clinical significance of EGFR and p16 expressions in the patients with advanced EACSCC to predict oncological outcomes.

  Jan. 2024, The Kobe journal of medical sciences, 69(4) (4), E144-E150, English, Domestic magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma.

  Sasa Vasilijic, Nadia A Atai, Hiroshi Hyakusoku, Steven Worthington, Yin Ren, Jessica E Sagers, Mehmet I Sahin, Alyssa Brown, Rohan Reddy, Charvi Malhotra, Takeshi Fujita, Lukas D Landegger, Richard Lewis, D Bradley Welling, Konstantina M Stankovic

  Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N > 170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a nine-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, and S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.

  Nov. 2023, Science advances, 9(45) (45), eadf7295, English, International magazine

  Scientific journal


• 放射線誘発前庭障害をきたした外耳道癌症例

  横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese


• 高齢者における人工内耳の装用効果

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese


• Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single-center study.

  Akihiro Yamada, Hirotaka Shinomiya, Natsumi Uehara, Keisuke Iritani, Shun Tatehara, Tatsuya Furukawa, Masanori Teshima, Daisuke Miyawaki, Takeshi Fujita, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  BACKGROUND: Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF-CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced EACSCC. METHODS: Thirty-five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF-CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a. RESULTS: Five-year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five-year progression-free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively. CONCLUSIONS: TPF-CCRT should be considered as a plausible treatment option for advanced EACSCC.

  Jul. 2023, Head & neck, English, International magazine

  Scientific journal


• Live Imaging of the Dehydration Effect of Isosorbide on the Normal and Hydropic Guinea Pig Cochleae Using Optical Coherence Tomography.

  Akinobu Kakigi, Naoya Egami, Takeshi Fujita, Natsumi Uehara, Jun Yokoi, Kento Koda, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba

  OBJECTIVE: To investigate the isosorbide-induced dehydration effect on the endolymphatic space by intratympanic administration of isosorbide. BACKGROUND: Isosorbide, an osmotic diuretic, is used orally as a typical conservative therapy for Menière's disease (MD) in Japan. The dehydration effect occurs 6 hours after isosorbide ingestion. Intratympanic administration of isosorbide resolves endolymphatic hydrops faster than oral ingestion. In addition, the dehydration effect has never been shown directly. Therefore, we investigated the dehydration effect of intratympanic administration of isosorbide on endolymphatic hydrops using optical coherence tomography. METHODS: We used eight Hartley guinea pigs, divided into normal and hydrops groups. In the hydrops group, the animals underwent endolymphatic sac obliteration to create endolymphatic hydrops. We obtained midmodiolar section images of the cochleae using optical coherence tomography. Then, 50 to 70% isosorbide was sequentially administered intratympanically for 5 minutes, and the apical turn of the cochlea was observed. The relative midmodiolar cross-sectional area of the scala media was calculated for quantitative assessment of the endolymphatic space. RESULTS: In the normal group, 50% isosorbide had a slight but significant dehydration effect on the scala media; at 55 to 70%, Reissner's membrane became flat. In the hydrops group, 50% isosorbide slightly reduced endolymphatic hydrops; 65% flattened Reissner's membrane, and 70% slightly concaved it toward the basilar membrane. CONCLUSION: The results suggest that we could select the concentration of isosorbide according to the stage or severity of MD and relief from acute attack. Intratympanic administration of isosorbide may be a promising treatment for patients with MD.

  Jul. 2023, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, English, International magazine

  Scientific journal


• Clinical trial on the efficacy and safety of NPC-15 for patients with xeroderma pigmentosum exaggerated sunburn reaction type: XP-1 study protocol for a multicentre, double-blinded, placebo-controlled, two-group crossover study followed by a long-term open study in Japan.

  Mariko Tsujimoto, Yasumasa Kakei, Nozomi Yamano, Takeshi Fujita, Takehiro Ueda, Ryusuke Ono, Sae Murakami, Shinichi Moriwaki, Chikako Nishigori

  INTRODUCTION: Xeroderma pigmentosum (XP) is a rare intractable disease without a fundamental treatment, presenting with severe photosensitivity, freckle-like pigmented and depigmented maculae and numerous skin cancers before the age of 10 years without strict sun protection. About 70% of the patients exhibit extremely severe sunburn reactions and most of them develop neurological symptoms, including sensorineural hearing impairment and progressive peripheral and central nervous disorders beginning from childhood ages. In the preclinical study, we found that N-acetyl-5-methoxytryptamine was effective in suppressing skin tumour development in addition to improvement of auditory brainstem response in chronically ultraviolet-irradiated XP-A model mice. METHODS AND ANALYSIS: On the bases of the preclinical study, we conduct a clinical trial on the efficacy of NPC-15 for patients with XP with exaggerated sunburn reaction type by a multicentre, double-blinded placebo-controlled, two-group crossover study followed by a 52 weeks open study. ETHICS AND DISSEMINATION: Ethics approval is overseen by the Kobe University Institutional Review Board and Osaka Medical and Pharmaceutical University Institutional Review Board, and the study is conducted in accordance with the approved protocol. All participants will be required to provide written informed consent. Findings will be disseminated through scientific and professional conferences and peer-reviewed journal publications. The data sets generated during the study will be available from the corresponding author on reasonable request. TRIAL REGISTRATION NUMBER: jRCTs051210181.

  Mar. 2023, BMJ open, 13(3) (3), e068112, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 耳科手術支援ロボットの開発

  藤田 岳, 上原 奈津美, 山下 俊彦, 西川 敦, 河合 俊和, 鈴木 寿, 横井 純, 柿木 章伸, 丹生 健一

  頭頸部外科領域にロボット手術が保険適応となり, 耳鼻咽喉科医にとってもロボット手術は身近な存在となってきた. しかし泌尿器・消化器領域で発展してきた手術ロボットを, そのまま耳や鼻の手術に応用することはまだ難しい. 私達は経外耳道的内視鏡下耳科手術 (Trans-canal Endoscopic Ear Surgery: TEES) を支援するロボットの研究・開発を複数の大学の工学部と共同で行っている. 手術ロボットの研究を通して, 自分たちの手術の特徴や問題点を改めて見直す機会が得られている. 本稿では, これまでの耳科手術用ロボットや内視鏡保持ロボットについて概略を述べ, 現在研究中の TEES 支援ロボットのコンセプトと試作機について述べる. また, 将来ロボット自身が自律的に手術を行うことを目標とした, ロボットの自律レベル向上に向けた研究についても紹介する.

  日本耳鼻咽喉科頭頸部外科学会, Mar. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(3) (3), 181 - 184, Japanese, Domestic magazine


• Genetic variants of cancer‑associated genes analyzed using next‑generation sequencing in small sporadic vestibular schwannomas.

  Takeshi Fujita, Kazuko Sakai, Natsumi Uehara, Yujiro Hoshi, Anjin Mori, Hajime Koyama, Mitsuo Sato, Kazuya Saito, Yasuhiro Osaki, Kazuto Nishio, Katsumi Doi

  Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. Despite the increasing diagnosis of sporadic VS over the past decade, the use of traditional microsurgeries to treat VS has decreased. This is likely a result of the adoption of serial imaging as the most common initial evaluation and treatment strategy, especially for small-sized VS. However, the pathobiology of VSs remains unclear, and elucidating the genetic information of tumor tissue may reveal novel insights. The present study performed a comprehensive genomic analysis of all exons in the key tumor suppressor and oncogenes from 10 small (<15 mm) sporadic VS samples. The evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2 and ETS1 as mutated genes. The current study could not draw any new conclusions about the relationship between VS-related hearing loss and gene mutations; however, it did reveal that NF2 was the most frequently mutated gene in small sporadic VS.

  Mar. 2023, Oncology letters, 25(3) (3), 121 - 121, English, International magazine

  Scientific journal


• Identification of Immune-Related Candidate Biomarkers in Plasma of Patients with Sporadic Vestibular Schwannoma.

  Sasa Vasilijic, Nadia A Atai, Hiroshi Hyakusoku, Steven Worthington, Yin Ren, Jessica E Sagers, Mehmet I Sahin, Takeshi Fujita, Lukas D Landegger, Richard Lewis, D Bradley Welling, Konstantina M Stankovic

  UNLABELLED: Vestibular schwannoma (VS) is intracranial tumor arising from neoplastic Schwann cells, causing hearing loss in about 95% of patients. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. Here, we conducted profiling of patients’ plasma for 67 immune-related factors on a large cohort of VS patients (N>120) and identified candidate biomarkers associated with tumor growth (IL-16 and S100B) and hearing (MDC). We identified the 7-biomarker panel composed of MCP-3, BLC, S100B, FGF-2, MMP-14, eotaxin, and TWEAK that showed outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS-induced hearing loss and provided a unique diagnostic tool that may predict hearing change and tumor growth in VS patients and may help inform the ideal timing of tumor resection to preserve hearing. TEASER: Profiling of plasma in vestibular schwannoma patients revealed biomarkers that could predict hearing change and tumor growth.

  Jan. 2023, bioRxiv : the preprint server for biology, English, International magazine


• miR-431 secreted by human vestibular schwannomas increases the mammalian inner ear's vulnerability to noise trauma.

  Takeshi Fujita, Richard Seist, Shyan-Yuan Kao, Vitor Soares, Lorena Panano, Radhika S Khetani, Lukas D Landegger, Shelley Batts, Konstantina M Stankovic

  INTRODUCTION: Vestibular schwannoma (VS) is an intracranial tumor that arises on the vestibular branch of cranial nerve VIII and typically presents with sensorineural hearing loss (SNHL). The mechanisms of this SNHL are postulated to involve alterations in the inner ear's microenvironment mediated by the genetic cargo of VS-secreted extracellular vesicles (EVs). We aimed to identify the EV cargo associated with poor hearing and determine whether its delivery caused hearing loss and cochlear damage in a mouse model in vivo. METHODS: VS tissue was collected from routinely resected tumors of patients with good (VS-GH) or poor (VS-PH) pre-surgical hearing measured via pure-tone average and word recognition scores. Next-generation sequencing was performed on RNA isolated from cultured primary human VS cells and EVs from VS-conditioned media, stratified by patients' hearing ability. microRNA expression levels were compared between VS-PH and VS-GH samples to identify differentially expressed candidates for packaging into a synthetic adeno-associated viral vector (Anc80L65). Viral vectors containing candidate microRNA were infused to the semicircular canals of mice to evaluate the effects on hearing, including after noise exposure. RESULTS: Differentially expressed microRNAs included hsa-miR-431-5p (enriched in VS-PH) and hsa-miR-192-5p (enriched in VS-GH). Newborn mice receiving intracochlear injection of viral vectors over-expressing hsa-miR-431-GFP, hsa-miR-192-GFP, or GFP only (control) had similar hearing 6 weeks post-injection. However, after acoustic trauma, the miR-431 group displayed significantly worse hearing, and greater loss of synaptic ribbons per inner hair cell in the acoustically traumatized cochlear region than the control group. CONCLUSION: Our results suggest that miR-431 contributes to VS-associated hearing loss following cochlear stress. Further investigation is needed to determine whether miR-431 is a potential therapeutic target for SNHL.

  2023, Frontiers in neurology, 14, 1268359 - 1268359, English, International magazine

  Scientific journal


• Vestibular function after simultaneous bilateral cochlear implantation in adults.

  Jun Yokoi, Takeshi Fujita, Natsumi Uehara, Shinobu Iwaki, Akinobu Kakigi, Ken-Ichi Nibu

  INTRODUCTION: Binaural hearing enhances speech intelligibility, source localization, and speech comprehension in noisy environments. Although bilateral cochlear implantation (CI) offers several benefits, concerns arise regarding the risk of bilateral postoperative vestibular dysfunction with simultaneous CI. This study aimed to longitudinally evaluate changes in vestibular function in adult patients who underwent simultaneous bilateral CI using minimally invasive electrodes and surgical techniques. METHODS: A retrospective review was conducted on 10 patients who underwent simultaneous bilateral CI at our hospital. Vertigo symptoms and vestibular function test results were examined preoperatively, 1-6 months postoperatively, and 1 year postoperatively. Nystagmus tests, caloric reflex tests, vestibular evoked myogenic potentials (VEMP) measurements, and static stabilometry were performed as vestibular function tests. RESULTS: Although an initial transient decline in vestibular function was observed, no significant long-term decline was observed in the caloric reflex test, ocular VEMP (oVEMP), or cervical VEMP (cVEMP). Moreover, regardless of the presence or absence of abnormalities in caloric reflex, oVEMP, or cVEMP, no significant deterioration was detected in the static stabilometer test. While two patients reported preoperative dizziness, all patients were symptom-free 1 year postoperatively. DISCUSSION: The findings suggest that using current minimally invasive electrodes and surgical techniques in simultaneous bilateral CI leads to temporary vestibular function decline postoperatively. However, most patients experience a recovery in function over time, highlighting the potential safety and efficacy of the procedure. Simultaneous bilateral CI surgery is viable, depending on the patient's auditory needs and burden.

  2023, Frontiers in neurology, 14, 1304927 - 1304927, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea

  Sayaka Katsunuma, Hideru Togashi, Shuhei Kuno, Takeshi Fujita, Ken-Ichi Nibu

  In the cochlear auditory epithelia, sensory hair and supporting cells are arranged in a checkerboard-like mosaic pattern, which is conserved across a wide range of species. The cell adhesion molecules nectin-1 and nectin-3 are required for this pattern formation. The checkerboard-like pattern is thought to be necessary for auditory function, but has never been examined. Here, we showed the significance of checkerboard-like cellular pattern in the survival and function of sensory hair cells in the cochlear auditory epithelia of nectin-3 knockout (KO) mice. Nectin-3 KO mice showed progressive hearing loss associated with degeneration of aberrantly attached hair cells via apoptosis. Apoptotic hair cell death was due to the disorganization of tight junctions between the hair cells. Our study revealed that the checkerboard-like cellular pattern in the auditory epithelium provides a structural basis for ensuring the survival of cochlear hair cells and hearing function.

  Frontiers Media SA, Dec. 2022, Frontiers in Cell and Developmental Biology, 10

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Editorial: Otologic Trauma, Pathology, and Therapy.

  Lukas D Landegger, Takeshi Fujita, Taha A Jan, Isabel Varela-Nieto

  2022, Frontiers in cellular neuroscience, 16, 900074 - 900074, English, International magazine


• Facial nerve palsy as the presenting feature of metastatic prostatic cancer in the temporal bone

  Daichi Fujii, Hikari Shimoda, Natsumi Uehara, Takeshi Fujita, Masanori Teshima, Hirotaka Shinomiya, Akinobu Kakigi, Tomoaki Terakawa, Masato Fujisawa, Ken-ichi Nibu

  Informa {UK} Limited, Dec. 2021, Acta Oto-Laryngologica Case Reports, 6(1) (1), 1 - 5

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Examination of risk factors for postoperative vestibular symptoms in patients with cholesteatoma.

  Takaaki Kobayashi, Shusuke Iwamoto, Toshihito Sahara, Yujiro Hoshi, Anjin Mori, Hajime Koyama, Takeshi Fujita, Mitsuo P Sato, Yasuhiro Osaki, Katsumi Doi

  BACKGROUND: In cholesteatoma, the prognosis of tympanoplasty has been well discussed in terms of hearing outcomes and residual or recurrent lesions. Postoperative dizziness and vertigo are major complications of tympanoplasty; however, few reports are available. AIMS/OBJECTIVES: We investigated each condition of cholesteatoma postoperative vestibular risk using the STAM system and staging published by EAONO/JOS, as well as findings on bony destruction. MATERIAL AND METHODS: From April 2010 to March 2021, 156 patients (166 ears) with cholesteatoma who underwent primary microscopic tympanoplasty at our hospital were registered. Subjective vestibular symptoms were recorded the day after surgery. RESULTS: Postoperative vestibular symptoms were observed in 13.9% of subjects. All of them were stage II and had both attic and mastoid lesions. Attic (p < .05) and mastoid (p < .01) lesions were risk factors. Multivariate analysis showed that significant differences were found in past histories of vestibular symptoms (p < .05) and exposure of the dura mater (p < .01). CONCLUSIONS AND SIGNIFICANCE: In the exposed dura group, the length of the prominence of the lateral semicircular canal to the middle cranial fossa dura was significantly shorter than that of the non-exposed group (p < .01). Narrow working space and downward operation may increase vestibular risk.

  Dec. 2021, Acta oto-laryngologica, 142(1) (1), 1 - 6, English, International magazine

  Scientific journal


• Genetic background in late-onset sensorineural hearing loss patients.

  Natsumi Uehara, Takeshi Fujita, Daisuke Yamashita, Jun Yokoi, Sayaka Katsunuma, Akinobu Kakigi, Shin-Ya Nishio, Ken-Ichi Nibu, Shin-Ichi Usami

  Genetic testing for congenital or early-onset hearing loss patients has become a common diagnostic option in many countries. On the other hand, there are few late-onset hearing loss patients receiving genetic testing, as late-onset hearing loss is believed to be a complex disorder and the diagnostic rate for genetic testing in late-onset patients is lower than that for the congenital cases. To date, the etiology of late-onset hearing loss is largely unknown. In the present study, we recruited 48 unrelated Japanese patients with late-onset bilateral sensorineural hearing loss, and performed genetic analysis of 63 known deafness gene using massively parallel DNA sequencing. As a result, we identified 25 possibly causative variants in 29 patients (60.4%). The present results clearly indicated that various genes are involved in late-onset hearing loss and a significant portion of cases of late-onset hearing loss is due to genetic causes. In addition, we identified two interesting cases for whom we could expand the phenotypic description. One case with a novel MYO7A variant showed a milder phenotype with progressive hearing loss and late-onset retinitis pigmentosa. The other case presented with Stickler syndrome with a mild phenotype caused by a homozygous frameshift COL9A3 variant. In conclusion, comprehensive genetic testing for late-onset hearing loss patients is necessary to obtain accurate diagnosis and to provide more appropriate treatment for these patients.

  Nov. 2021, Journal of human genetics, 67(4) (4), 223 - 230, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Machine Learning Technique Reveals Prognostic Factors of Vibrant Soundbridge for Conductive or Mixed Hearing Loss Patients.

  Hajime Koyama, Anjin Mori, Daisuke Nagatomi, Takeshi Fujita, Kazuya Saito, Yasuhiro Osaki, Tatsuya Yamasoba, Katsumi Doi

  OBJECTIVES: Vibrant Soundbridge (VSB) was developed for treatment of hearing loss, but clinical outcomes vary and prognostic factors predicting the success of the treatment remain unknown. We examined clinical outcomes of VSB for conductive or mixed hearing loss, prognostic factors by analyzing prediction models, and cut-off values to predict the outcomes. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary care hospital. PATIENTS: Thirty patients who underwent VSB surgery from January 2017 to December 2019 at our hospital. INTERVENTION: Audiological tests were performed prior to and 3 months after surgery; patients completed questionnaires 3 months after surgery. MAIN OUTCOME MEASURES: We used a multiregression and the random forest algorithm for predictions. Mean absolute errors and coefficient of determinations were calculated to estimate prediction accuracies. Coefficient values in the multiregression model and the importance of features in the random forest model were calculated to clarify prognostic factors. Receiver operation characteristic curves were plotted. RESULTS: All audiological outcomes improved after surgery. The random forest model (mean absolute error: 0.06) recorded more accuracy than the multiregression model (mean absolute error: 0.12). Speech discrimination score in a silent context in patients with hearing aids was the most influential factor (coefficient value: 0.51, featured value: 0.71). The candidate cut-off value was 36% (sensitivity: 89%, specificity: 75%). CONCLUSIONS: VSB is an effective treatment for conductive or mixed hearing loss. Machine learning demonstrated more precise predictions, and speech discrimination scores in a silent context in patients with hearing aids were the most important factor in predicting clinical outcomes.

  Oct. 2021, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 42(9) (9), e1286-e1292, English, International magazine

  Scientific journal


• Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal.

  Hirotaka Shinomiya, Natsumi Uehara, Takeshi Fujita, Daisuke Miyawaki, Yoshinori Imamura, Masanori Teshima, Akinobu Kakigi, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

  PURPOSE: Chemoradiotherapy with docetaxel (DOC), cisplatin (CDDP), and 5-FU (TPF-CRT) for locally advanced external auditory canal cancer (EACC) has favorable oncological and functional outcomes. To establish TPF-CRT as a standard of care for advanced EACC, we conducted this study to determine the maximum tolerated (MTD) and recommended dose (RD) of DOC in TPF-CRT for locally advanced EACC. METHODS: To determine the recommended (RD) and maximum tolerated dose (MTD) of DOC in TPF-CRT for EACC, a phase I trial was conducted using the standard "3 + 3" design for maximum dose finding. DOC was administered twice every 4 weeks, CDDP at 70 mg/m2 and 5-FU at 700 mg/m2; patients were also receiving radiotherapy (66 Gy). Eight patients with T3 or T4 EACC were prospectively enrolled. RESULTS: Two patients treated with DOC, 50 mg/m2, and one out of six patients treated with DOC, 40 mg/m2, had dose-limiting toxicities. Prolonged febrile neutropenia was observed in three patients. Grade 3 non-hematological toxicities were observed in only three patients. At study completion, six patients survived, five of whom were disease free. CONCLUSION: The RD and MTD of DOC in TPF-CRT for locally advanced EACC are 40 mg/m2 when doses of CDDP and 5-FU are 70 mg/m2 and 700 mg/m2, respectively.

  Jul. 2021, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 279(6) (6), 2805 - 2810, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear

  H Shinomiya, N Uehara, T Fujita, K Yoshida, Y Imamura, M Teshima, H Kimura, D Miyawaki, A Kakigi, N Kiyota, N Otsuki, R Sasaki, E Kohmura, K Nibu

  The prognosis of patients with advanced squamous cell carcinoma of the external auditory canal and middle ear has been improved by advances in skull base surgery and multidrug chemoradiotherapy during the last two decades. Ninety-five patients with squamous cell carcinoma of the external auditory canal and middle ear who were treated between 1998 and 2017 were enrolled. The number of patients with tumour stages T₁, T₂, T₃ and T₄ was 15, 22, 24 and 34, respectively. Oncological outcomes and prognostic factors were retrospectively investigated. Among patients with T₄ disease, invasion of the brain (p = 0.024), carotid artery (p = 0.049) and/or jugular vein (p = 0.040) were significant predictors of poor prognosis. The five-year overall survival rate of patients with at least one of these factors (T_4b) was significantly lower than that of patients without these factors (T_4a) (25.5 vs 65.5 per cent, p = 0.049). It is proposed that stage T₄ be subclassified into T_4a and T_4b according to the prognostic factors.

  Cambridge University Press (CUP), Apr. 2021, The Journal of Laryngology & Otology, 135(4) (4), 297 - 303

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 当科における顔面神経鞘腫23例の検討

  下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二

  顔面神経鞘腫の治療において村上らが提唱した治療アルゴリズムは、顔面神経麻痺の程度が主な基準となり、柳原法で20点未満が外科的介入の対象となるが、病変が頭蓋内に進展している例や随伴症状によっては20点以上であっても根治切除を行うことがある。一方、20点未満であっても患者背景やQOLを考慮して経過観察や放射線治療を選択する場合もある。今回、当科で2005～2020年に顔面神経鞘腫と診断した23例の治療アルゴリズムを後方視的に検討した。側頭骨内顔面神経鞘腫22例のうち、麻痺スコア20点未満の10例中8例に手術治療を選択し、8例とも全摘術を行っていた。麻痺スコア20点以上の症例では12例中9例に手術治療を選択しており、経過観察は3例のみであった。腫瘍切除後は全例に即時的再建を行っていた。術後1年以上の経過が追えた9例について再建後の麻痺スコアの推移をみると、術後1年以降の平均スコアは13.4点で、8点以下が2例、10～18点が1例、20点以上が6例であった。

  日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese


• Vestibular function in minimally invasive cochlear implantation

  Jun Yokoi, Shun-Gaku Yanagisawa, Akinobu Kakigi, Takeshi Fujita, Shinobu Iwaki, Yasuyuki Kajimoto, Ken-Ichi Nibu

  Japan Society for Equilibrium Research, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese

  Scientific journal


• Reconstruction of the external auditory canal using full-thickness rolled-up skin graft after lateral temporal bone resection for T1 and T2 external auditory canal cancer.

  Takeshi Fujita, Akinobu Kakigi, Natsumi Uehara, Jun Yokoi, Makiko Hara, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu

  OBJECTIVE: To present our results of the external auditory canal (EAC) reconstruction procedure using rolled-up full-thickness skin graft with tympanoplasty after lateral temporal bone resection (LTBR) for early-stage EAC carcinoma. PATIENTS AND METHODS: A retrospective review of 15 patients who had undergone LTBR with reconstruction of the EAC for T1 and T2 EAC cancer between 2016 and 2020. RESULTS: Postoperative mean air-bone gap was 30.7 decibel hearing level. Although a few patients experienced chronic granulation, persistent otorrhea, and/or laterization of the tympanic membrane, most patients showed no serious complications related to the EAC reconstruction. CONCLUSION: EAC reconstruction using a full-thickness skin graft in combination with tympanoplasty is useful for minimizing the hearing loss, maintaining the cosmetic appearance, and facilitating the observation into the ear cavity.

  Jan. 2021, Auris, nasus, larynx, English, International magazine

  Scientific journal


• 両側同時人工内耳手術を施行した成人例における聴取成績

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2020, Audiology Japan, 63(5) (5), 333 - 333, Japanese


• Tonsillectomy as an effective treatment for arthralgia of SAPHO syndrome

  Sena Horiguchi, Takeshi Fujita, Koji Kinoshita, Katsumi Doi

  Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome has been proposed to describe a clinicoradiological entity manifesting in the joints, skin and bones. We describe a patient with SAPHO syndrome for whom bilateral tonsillectomy was effective for the treatment of arthralgia, which was quantified using multiple pain scales.

  Oxford University Press ({OUP}), Sep. 2020, Journal of Surgical Case Reports, 2020(9) (9), rjaa288, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Live imaging and functional changes of the inner ear in an animal model of Meniere's disease.

  Akinobu Kakigi, Naoya Egami, Natsumi Uehara, Takeshi Fujita, Ken-Ichi Nibu, Shinji Yamashita, Tatsuya Yamasoba

  The symptoms of Meniere's disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere's disease. Based on this, we developed a clinically relevant animal model of Meniere's disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner's membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist.

  Jul. 2020, Scientific reports, 10(1) (1), 12271 - 12271, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Traumatic perilymphatic fistula caused by a camellia branch: A case report

  Natsumi Uehara, Takeshi Fujita, Ken-ichi Nibu, Akinobu Kakigi

  Jan. 2020, Acta Oto-Laryngologica Case Reports, 5(1) (1), 101 - 105, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Prevalence of potential candidates for electric-acoustic stimulation implant in a hearing-impaired population.

  Saito K, Fujita T, Osaki Y, Koyama H, Shiraishi K, Kobayashi T, Sato M, Seo T, Doi K

  OBJECTIVE: To estimate the prevalence of potential electric-acoustic stimulation (EAS) implant candidates in a hearing-impaired population through a review of auditory examinations. METHODS: In total, 7356 patients underwent audiometric examination in our department between 2011 and 2014. The prevalence of patients meeting the audiometric criteria for EAS and standard cochlear implant (CI) was assessed. RESULTS: The percentage of EAS implant candidates meeting the pure-tone audiometric criteria was 0.71% (n=34) among the hearing-impaired individuals (n=4758) examined in our department, whereas 2.52% (n=120) met the criteria for standard CI. Among the 34 EAS implant candidates, 2 individuals (5.83%) received EAS implant surgery after approval of the EAS device in Japan. CONCLUSIONS: There was a lower prevalence of EAS implant candidates than standard CI candidates. Nevertheless, healthcare professionals should carefully examine the audiograms of patients with high frequency hearing loss with regard to meeting the indication criteria for EAS implant. This will enable patients to gain access to adequate information relating to further examinations and treatment options.

  Aug. 2019, Auris, nasus, larynx, 47(2) (2), 198 - 202, English, International magazine

  [Refereed]

  Scientific journal


• Primary Liposarcoma with Cholesteatoma in Mastoid.

  Sato MP, Saito K, Fujita T, Seo T, Doi K

  Jul. 2019, The journal of international advanced otology

  [Refereed]


• The prevalence of vestibular schwannoma among patients treated as sudden sensorineural hearing loss

  Takeshi Fujita, Kazuya Saito, Nobuo Kashiwagi, Mitsuo Sato, Toru Seo, Katsumi Doi

  Elsevier {BV}, Feb. 2019, Auris Nasus Larynx, 46(1) (1), 78 - 82

  [Refereed]

  Scientific journal


• Vestibule-Middle Ear Dehiscence Tested With Perilymph-Specific Protein Cochlin-Tomoprotein (CTP) Detection Test.

  Fujita T, Kobayashi T, Saito K, Seo T, Ikezono T, Doi K

  An 8-year-old boy was referred to the ENT department for further evaluation of right-sided conductive hearing loss. A small cyst anterior to the oval window and fixation of the stapes footplate were observed during an exploratory tympanotomy. The concentration of a perilymph-specific protein, cochlin-tomoprotein (CTP), in the middle ear lavage fluid was measured with an ELISA-based CTP detection kit. The level of CTP in the middle ear lavage fluid before fenestration of the cyst was 0.26 ng/ml (negative), and its level after fenestration was 2.98 ng/ml (positive), confirming the presence of perilymph in the cyst. A small bone dehiscence, considered to be the fissula ante fenestram, was observed anterior to the stapes footplate after removal of the cyst. The CTP detection test results allowed us to confirm that the small bone dehiscence was connected to the inner ear.

  2019, Frontiers in neurology, 10, 47 - 47, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma.

  Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L

  Jan. 2019, Nature protocols

  [Refereed]


• Cytokine Levels in Inner Ear Fluid of Young and Aged Mice as Molecular Biomarkers of Noise-Induced Hearing Loss.

  Lukas D Landegger, Sasa Vasilijic, Takeshi Fujita, Vitor Y Soares, Richard Seist, Lei Xu, Konstantina M Stankovic

  Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, frequently caused by noise trauma and aging, with inflammation being implicated in both pathologies. Here, we provide the first direct measurements of proinflammatory cytokines in inner ear fluid, perilymph, of adolescent and 2-year-old mice. The perilymph of adolescent mice exposed to the noise intensity resulting in permanent auditory threshold elevations had significantly increased levels of IL-6, TNF-α, and CXCL1 6 h after exposure, with CXCL1 levels being most elevated (19.3 ± 6.2 fold). We next provide the first immunohistochemical localization of CXCL1 in specific cochlear supporting cells, and its presumed receptor, Duffy antigen receptor for chemokines (DARC), in hair cells and spiral ganglion neurons. Our results demonstrate the feasibility of molecular diagnostics of SNHL using only 0.5 μL of perilymph, and motivate future sub-μL based diagnostics of human SNHL based on liquid biopsy of the inner ear to guide therapy, promote hearing protection, and monitor response to treatment.

  2019, Frontiers in neurology, 10, 977 - 977, English, International magazine

  [Refereed]

  Scientific journal


• Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models.

  Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, Plotkin SR, Stankovic KM, Jain RK, Xu L

  Feb. 2018, Proceedings of the National Academy of Sciences of the United States of America, 115(9) (9), E2077 - E2084

  [Refereed]


• Recent and Frequent Vertigo Attacks Produce Negative Findings on Furosemide-Loading Vestibular Evoked Myogenic Potential Testing in Meniere's Disease.

  Seo T, Shiraishi K, Kobayashi T, Fujita T, Saito K, Doi K

  Objective: The peak-to-peak amplitude of the p13-n23 wave in cervical vestibular evoked myogenic potential can increase after furosemide administration in patients with Meniere's disease [furosemide-loading VEMP (FVEMP) testing]. The examination is used to test for the presence of endolymphatic hydrops; we investigated factors that may influence the results. Methods: Forty-two subjects (23 males and 19 females, aged 24-70 years) with unilateral definite Meniere's disease who underwent FVEMP testing were retrospectively studied. Possible factors associated with the results of FVEMP testing were studied using logistic regression analysis. Results: Ages, sex, affected side, stage, disease duration, and mean hearing level of pure tone audiometry did not influence the results of FVEMP testing in the univariate analysis (p > 0.05). Number of days since the last vertigo attack [odds ratio (OR): 1.07, p = 0.031] and frequency of vertigo attacks per month (OR: 0.42, p = 0.003) were significantly associated with the results of testing. Multivariate analysis showed that both days since the last vertigo attack < 7 (OR: 0.13, p = 0.04) and frequency of vertigo attacks per month ≥ 2 (OR: 0.06, p = 0.004) were risk factors for negative results on FVEMP testing. Conclusion: This study found that recent and frequent vertigo attacks produced negative findings on FVEMP testing in Meniere's disease. This apparently irrational finding can be explained by the consequences of membranous labyrinth rupture during vertigo attacks, where the altered saccular resonance due to EH cannot be recovered by furosemide administration because of the dissolving dehydration effect that occurs through communication between the endolymphatic and perilymphatic spaces. In addition, the impairment of sensory cells that is caused by endolymph and perilymph mixing upon rupture does not improve upon furosemide administration. FVEMP testing results may provide us with pathophysiological information regarding the membranous labyrinth.

  2018, Frontiers in neurology, 9, 636 - 636, English, International magazine

  [Refereed]

  Scientific journal


• A Unified Methodological Framework for Vestibular Schwannoma Research

  Lukas D. Landegger, Jessica E. Sagers, Sonam Dilwali, Takeshi Fujita, Mehmet I. Sahin, Konstantina M. Stankovic

  Jun. 2017, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (124) (124), English

  [Refereed]

  Scientific journal


• Hearing Dysfunction in Xpa-Deficient Mice

  Hitomi Shinomiya, Daisuke Yamashita, Takeshi Fujita, Eiji Nakano, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Chikako Nishigori, Ken-ichi Nibu

  Feb. 2017, FRONTIERS IN AGING NEUROSCIENCE, 9, 19, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Residual dizziness after successful treatment of idiopathic benign paroxysmal positional vertigo originates from persistent utricular dysfunction

  Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Hiroyasu Watanabe, Katsumi Doi

  2017, ACTA OTO-LARYNGOLOGICA, 137(11) (11), 1149 - 1152, English

  [Refereed]

  Scientific journal


• Revision of a furosemide-loading vestibular-evoked myogenic potential protocol for detecting endolymphatic hydrops

  Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Katsumi Doi

  2017, ACTA OTO-LARYNGOLOGICA, 137(12) (12), 1244 - 1248, English

  [Refereed]

  Scientific journal


• Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells

  Vitor Y. R. Soares, Nadia A. Atai, Takeshi Fujita, Sonam Dilwali, Sarada Sivaraman, Lukas D. Landegger, Fred H. Hochberg, Carlos A. P. C. Oliveira, Fayez Bahmad, Xandra O. Breakefield, Konstantina M. Stankovic

  Nov. 2016, NEURO-ONCOLOGY, 18(11) (11), 1498 - 1507, English

  [Refereed]

  Scientific journal


• Sulforaphane, a natural component of broccoli, inhibits vestibular schwannoma growth in vitro and in vivo

  Bo Gyung Kim, Takeshi Fujita, Konstantina M. Stankovic, D. Bradley Welling, In Seok Moon, Jae Young Choi, Jieun Yun, Jong Soon Kang, Jong Dae Lee

  Nov. 2016, SCIENTIFIC REPORTS, 6, 36215, English

  [Refereed]

  Scientific journal


• Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

  Takeshi Fujita, Jung Eun Shin, MaryBeth Cunnane, Kyoko Fujita, Simon Henein, Demetri Psaltis, Konstantina M. Stankovic

  Sep. 2016, OTOLOGY & NEUROTOLOGY, 37(8) (8), 1189 - 1194, English

  [Refereed]

  Scientific journal


• Metabolomic profiling in inner ear fluid by gas chromatography/mass spectrometry in guinea pig cochlea

  Takeshi Fujita, Daisuke Yamashita, Yasuhiro Irino, Junko Kitamoto, Yuriko Fukuda, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Masaru Yoshida, Ken-ichi Nibu

  Oct. 2015, NEUROSCIENCE LETTERS, 606, 188 - 193, English

  [Refereed]

  Scientific journal


• Preclinical validation of anti-nuclear factor-kappa B therapy to inhibit human vestibular schwannoma growth

  Sonam Dilwali, Martijn C. Briet, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Michael P. Platt, Konstantina M. Stankovic

  Aug. 2015, MOLECULAR ONCOLOGY, 9(7) (7), 1359 - 1370, English

  [Refereed]

  Scientific journal


• Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas

  Sonam Dilwali, Shyan-Yuan Kao, Takeshi Fujita, Lukas D. Landegger, Konstantina M. Stankovic

  Jul. 2015, TRANSLATIONAL RESEARCH, 166(1) (1), 1 - 11, English

  [Refereed]

  Scientific journal


• A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice

  Takeshi Fujita, Daisuke Yamashita, Natsumi Uehara, Go Inokuchi, Shingo Hasegawa, Naoki Otsuki, Ken-ichi Nibu

  Jan. 2015, PLOS ONE, 10(1) (1), e0117547, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Persistent petrosquamosal sinus: Underlying cause of otitic hydrocephalus with lateral sinus thrombosis

  Go Inokuchi, Nao Tsutsumi, Hirokazu Komatsu, Takeshi Fujita, Naoki Sawada, Kazuo Kumoi

  Nov. 2013, INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 77(11) (11), 1908 - 1911, English

  [Refereed]

  Scientific journal


• Serum and Tissue Metabolomics of Head and Neck Cancer

  Koichiro Yonezawa, Shin Nishiumii, Junko Kitamoto-Matsuda, Takeshi Fujita, Koichi Morimoto, Daisuke Yamashita, Miki Saito, Naoki Otsuki, Yasuhiro Irino, Masakazu Shinohara, Masaru Yoshida, Ken-Ichi Nibu

  Sep. 2013, CANCER GENOMICS & PROTEOMICS, 10(5) (5), 233 - 238, English

  [Refereed]

  Scientific journal


• Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes

  Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto, Ken-ichi Nibu

  Nov. 2012, DIABETES, 61(11) (11), 2980 - 2986, English

  [Refereed]

  Scientific journal

• 耳科手術におけるロボットと手術支援技術

  藤田 岳

  日本耳鼻咽喉科臨床学会, Jan. 2026, 耳鼻咽喉科臨床, 119(1) (1), 62 - 63, Japanese


• 神経線維腫症II型(NF2)に対して人工内耳手術を施行した2症例

  赤座 暁子, 藤田 岳, 岩城 忍, 鷲見 麻里, 上原 奈津美, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Dec. 2025, Otology Japan, 35(4) (4), 288 - 295, Japanese


• 酵素補充療法後のFabry病に発症した急性感音難聴の1例

  松尾 聡一郎, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (株)医学書院, Nov. 2025, 耳鼻咽喉科・頭頸部外科, 97(12) (12), 1017 - 1021, Japanese


• 医療関係者を対象とした生理痛疑似体験による意識変容の検討 性差とダイバーシティ教育の観点から

  高橋 剛史, 小川 武則, 藤田 岳, 丸山 裕美子, 森田 由香, 松浦 一登, 一般社団法人日本耳鼻咽喉科頭頸部外科学会ダイバーシティ・働き方改革委員会

  (一社)日本耳鼻咽喉科頭頸部外科学会, Nov. 2025, 日本耳鼻咽喉科頭頸部外科学会会報, 128(11) (11), 1255 - 1262, Japanese


• 【頭蓋底手術を極める!】外側頭蓋底 外側側頭骨切除

  藤田 岳

  (株)医学書院, Oct. 2025, 耳鼻咽喉科・頭頸部外科, 97(11) (11), 936 - 939, Japanese


• 聴神経腫瘍における難聴メカニズムと分子基盤の解明

  藤田 岳

  (株)メディカルレビュー社, Sep. 2025, 鼻アレルギーフロンティア, 25(2) (2), 106 - 108, Japanese


• 聴神経腫瘍における難聴メカニズムと分子基盤の解明

  藤田 岳

  (一社)日本耳科学会, May 2025, Otology Japan, 35(2) (2), 63 - 67, Japanese


• 長期経過を追えたミトコンドリア病2例に関する検討

  上原 奈津美, 藤田 岳, 丹生 健一

  日本小児耳鼻咽喉科学会, May 2025, 小児耳鼻咽喉科, 46(Suppl.) (Suppl.), 132 - 132, Japanese


• ベンラリズマブを使用した好酸球性副鼻腔炎・中耳炎の2例

  上原 奈津美, 由井 光子, 藤田 岳, 丹生 健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, Apr. 2025, 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 5回, 230 - 230, Japanese


• OTOPLANを用いたFLEXsoft人工内耳電極の検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2025, 日本耳鼻咽喉科頭頸部外科学会会報, 128(4) (4), 690 - 690, Japanese


• How to handle the stapes in tympanoplasty

  藤田岳

  (株)医学書院, 2025, 耳鼻咽喉科・頭頚部外科, 97(2) (2), 120 - 123, Japanese


• 耳鼻咽喉科・頭頸部外科領域の手術手技トレーニング 神戸大学臨床解剖セミナー

  藤田岳, 井之口豪, 井之口豪

  (株)東京医学社, 2025, JOHNS, 41(3) (3), 333 - 336, Japanese


• Evaluation of the effects of biologic therapy on otitis media in eosinophilic chronic rhinosinusitis

  上原奈津美, 横井純, 由井光子, 井之口豪, 藤田岳, 柿木章伸, 丹生健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, 2025, 日本耳鼻咽喉科免疫アレルギー感染症学会誌(Web), 5(1) (1), 35 - 39, Japanese


• 日本語を母語としない外国人の両側同時人工内耳手術後の日本語聴取能について

  岩城忍, 上原奈津美, 藤田岳, 柿木章伸, 丹生健一

  日本耳鼻咽喉科臨床学会, 2025, 耳鼻咽喉科臨床 補冊, (168) (168), 143 - 143, Japanese


• 【TEES】TEESで治す ロボット手術との関わり

  藤田 岳

  (株)東京医学社, Dec. 2024, JOHNS, 40(12) (12), 1535 - 1537, Japanese


• 外耳癌 診断から治療・術後管理まで 耳科手術専門医が知っておきたい技術 外耳道癌に対する外側側頭骨切除術の適応と実際

  藤田 岳, 柿木 章伸

  (一社)日本耳科学会, Dec. 2024, Otology Japan, 34(4) (4), 183 - 186, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)により鼓膜穿孔,耳小骨破壊をきたした1例

  繁治 純, 藤田 岳, 井之口 豪, 安井 理絵

  日本小児耳鼻咽喉科学会, Dec. 2024, 小児耳鼻咽喉科, 45(2) (2), 155 - 158, Japanese


• Optimizing indications and techniques for lateral temporal bone resection in early-stage external auditory canal carcinoma

  藤田岳, 柿木章伸

  (一社)日本耳科学会, Dec. 2024, Otology Japan, 34(4) (4), 183 - 186, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)により鼓膜穿孔,耳小骨破壊をきたした1例

  繁治 純, 藤田 岳, 井之口 豪, 安井 理絵

  日本小児耳鼻咽喉科学会, Dec. 2024, 小児耳鼻咽喉科, 45(2) (2), 155 - 158, Japanese


• 【TEES】TEESで治す ロボット手術との関わり

  藤田 岳

  (株)東京医学社, Dec. 2024, JOHNS, 40(12) (12), 1535 - 1537, Japanese


• 日耳鼻若手会員・基幹施設への出産・育児に関するアンケート調査結果 働き方改革に関するワーキンググループ報告

  藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一, 日本耳鼻咽喉科頭頸部外科学会働き方改革に関するワーキンググループ

  (一社)日本耳鼻咽喉科頭頸部外科学会, Oct. 2024, 日本耳鼻咽喉科頭頸部外科学会会報, 127(10) (10), 1064 - 1071, Japanese


• 【耳鼻咽喉科頭頸部外科領域のサブスペシャルティ-手術指導医・専門医・相談医マニュアル-】耳科手術指導の実際 知っておくべき耳科手術の施設基準,実施医制度,執刀医要件

  藤田 岳

  (株)東京医学社, Oct. 2024, JOHNS, 40(10) (10), 1247 - 1251, Japanese


• Mechanisms of hearing loss and the underlying molecular basis in vestibular schwannoma

  藤田岳

  (一社)日本耳科学会, Oct. 2024, Otology Japan, 34回(2) (2), 9 - 9, Japanese


• 小さな宇宙を探究する～耳科学イメージングの世界～ 医工融合で蝸牛内部の可視化を目指す

  藤田 岳

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 14 - 14, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 局訳版QOL質問票を用いた検討(第3報)

  細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 高橋 邦行, 山岸 達矢, 松本 希, 藤田 岳, 美内 慎也, 赤井 亮, 白井 杏湖, 樫尾 明憲, 土井 勝美, 大平 乃理子, 伊藤 吏, 後藤 崇成, 高橋 昌寛, 高橋 真理子, 高橋 優宏, 小森 学, 山内 大輔, 本蔵 陽平, 平海 晴一, 綾仁 悠介, 岡田 昌浩, 山本 典生, 池園 哲郎, 松田 帆, 宇佐美 真一, 萩森 伸一, 中川 尚志, 大石 直樹, 東野 哲也, 神崎 晶

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 113 - 113, Japanese


• 当院におけるアッシャー症候群の検討

  上原 奈津美, 横井 純, 藤田 岳, 西尾 信哉, 柿木 章伸, 松永 達雄, 宇佐美 真一, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 185 - 185, Japanese


• 神経線維種症II型(NF2)に対して人工内耳植込術を施行した2症例

  赤座 暁子, 藤田 岳, 上原 奈津美, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 220 - 220, Japanese


• OTOPLANを用いたFLEXsoft人工内耳電極の周波数ミスマッチに関する検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 242 - 242, Japanese


• グロムス腫瘍との鑑別に苦慮した側頭骨内顔面神経鞘腫の1例

  渡辺 啓太, 藤田 岳, 横井 純, 柿木 章伸, 上原 奈津美, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 272 - 272, Japanese


• 長期抗菌薬投与を継続しながら外来治療に移行した頭蓋底骨髄炎の一例

  水本 真理愛, 上原 奈津美, 小池 雪絵, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2024, 日本耳科学会総会・学術講演会抄録集, 34回, 295 - 295, Japanese


• 術前に内耳造影MRIにて内リンパ水腫を認めた耳硬化症例

  横井 純, 藤田 岳, 山下 俊彦, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2024, Equilibrium Research, 83(5) (5), 396 - 396, Japanese


• 高度難聴と幻聴を伴う統合失調症症例に対する人工内耳装用効果について

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2024, Audiology Japan, 67(5) (5), 448 - 448, Japanese


• 【耳科診療の論点-異なる立場の対話とディベート-】さまざまな手術法の中から 耳科手術の3鏡について 顕微鏡のメリット,デメリット

  藤田 岳

  (株)東京医学社, Mar. 2024, JOHNS, 40(3) (3), 308 - 310, Japanese


• A case of middle ear actinomycosis without otalgia that was difficult to diagnose

  上原奈津美, 神澤真紀, 横井純, 由井光子, 井之口豪, 藤田岳, 柿木章伸, 丹生健一

  症例は22歳男性で、左耳閉感、拍動性耳鳴を主訴とし、10ヵ月前に近医にて急性中耳炎として加療された。症状は一時的に改善したが再燃した。痛みは無く、左伝音難聴と左鼓膜に白色の膨隆病変を認め腫瘍を疑った。側頭骨高分解能CTで左鼓室内に充満する軟部陰影を認め、造影MRIで同部位の均一な濃染を認めた。診断目的で試験的鼓室開放術を行った。その結果、鼓室内は肉芽様組織で充満し粘調な貯留液と黄色の菌塊を認め、細菌培養、抗酸菌培養検査に提出した。肉芽病変は炎症性肉芽組織で、菌塊からActinomyces属を検出し抗菌薬を6ヵ月間投与した。術後1年現在、再発は無い。放線菌症は非常に稀で、耳痛や炎症所見が無かったため診断に難渋した。難治性中耳炎を認めた場合は放線菌症を念頭に置いて特徴的な病変である硫黄顆粒に留意し、16S rRNA遺伝子解析、病理学的検査を行う必要があると考えられた。

  日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会誌(Web), 4(1) (1), 31 - 36, Japanese


• 好酸球性副鼻腔炎に対するバイオ製剤治療による中耳炎への効果の検討

  上原 奈津美, 由井 光子, 藤田 岳, 井之口 豪, 柿木 章伸, 丹生 健一

  日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2024, 日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 4回, 216 - 216, Japanese


• 当科で手術治療をした耳下腺内顔面神経鞘腫の3例

  下田光, 横井純, 上原奈津美, 藤田岳, 柿木章伸, 丹生健一, 榊原俊介, 橋川和信

  2024, 日本頭蓋底外科学会プログラム・抄録集, 36th


• 両側人工内耳装用者の両耳聴効果についての検討

  鷲見麻里, 岩城忍, 横井純, 上原奈津美, 藤田岳, 柿木章伸, 丹生健一

  2024, 日本言語聴覚学会(Web), 25th


• 可動式ピボットと3自由度の直交座標系で構成する耳科内視鏡マニピュレータ

  高松道聡, 河合俊和, 藤田岳, 上原奈津美, 山下俊彦, 西川敦, 鈴木寿

  2024, 日本ロボット学会学術講演会予稿集(CD-ROM), 42nd


• 酵素補充療法後の Fabry 病に発症した突発性難聴の1例

  松尾聡一郎, 上原奈津美, 横井純, 岩城忍, 藤田岳, 柿木章伸, 丹生健一

  2024, Audiology Japan, 67(5) (5)


• Visual Field Evaluation Based on Surgical Instrument Detection in Endoscopic Ear Surgery Images Using Deep Learning and Its Application to Endoscope-Holding Robot Control

  丸川可南子, 厚海慶太, 厚海慶太, 松居和寛, 松居和寛, 藤田岳, 上原奈津美, 山下俊彦, 河合俊和, 鈴木寿, 平井宏明, 西田亮介, 川村貞夫, 川村貞夫, 西川敦

  2024, 計測自動制御学会システムインテグレーション部門講演会(CD-ROM), 25th


• Endoscopic Video Analysis Using Deep Learning for Autonomous Control of a Robot-Assisted Endoscopic Ear Surgery System

  西坂大志, 丸川可南子, 厚海慶太, 厚海慶太, 松居和寛, 松居和寛, 藤田岳, 上原奈津美, 山下俊彦, 河合俊和, 鈴木寿, 平井宏明, 西田亮介, 川村貞夫, 川村貞夫, 西川敦

  2024, 計測自動制御学会システムインテグレーション部門講演会(CD-ROM), 25th


• 頭頸部傍神経節腫(HNPGL)におけるコハク酸脱水素酵素(SDH)遺伝子変異の影響

  下田光, 横井純, 上原奈津美, 藤田岳, 北山恵, 志賀清人, 松永達雄, 小澤宏之, 柿木章伸, 丹生健一

  2024, 日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM), 33rd


• 外耳道癌に対する外側側頭骨切除術における切除断端,頸部郭清,耳下腺合併切除の意義について

  堀地祐人, 四宮弘隆, 藤田岳, 柿木章伸, 丹生健一

  2024, 日本頭頸部外科学会総会ならびに学術講演会プログラム・予稿集(CD-ROM), 33rd


• 中耳真珠腫による顔面神経麻痺症例の検討

  上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  当科で2016～2023年に初回手術を行った中耳真珠腫169例のうち、術前に顔面神経麻痺を認めていた5例を対象とし、「術前の柳原スコア」「術前の鼓膜・耳内所見」「麻痺発症から手術までの期間」「術式」「術中所見」「術後の柳原スコア」「病的共同運動の有無」「術前後の聴力」などについて検討した。男性3例、女性2例、年齢は45～83歳であった。術前の柳原スコアは2～38点で、完全麻痺が2例、不完全麻痺3例であった。術前の鼓膜・耳内所見は、3例は外耳道が腫脹していたため鼓膜を観察できず、膿性耳漏を伴っていた。2例は弛緩部型真珠腫で、硬いdebrisの貯留を認めた。発症から手術までの期間は1週間以内が3例、約1ヵ月が2例で、1週間以内に手術した症例はいずれも柳原スコアが40点まで改善し、病的共同運動も軽度もしくは認めなかった。発症後約1ヵ月で手術した2例のうち、不完全麻痺の1例は軽度の病的共同運動、完全麻痺の1は中等度の病的共同運動を認めた。術式は、4例に一期的な外耳道後壁削除型鼓室形成術を施行した。残りの1例は45歳と若く、外耳道後壁保存型鼓室形成術で段階手術とした。術後の聴力は5例とも術前とほとんど変わらなかった。

  日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese


• 中耳真珠腫による顔面神経麻痺症例の検討

  上原 奈津美, 下田 光, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  当科で2016～2023年に初回手術を行った中耳真珠腫169例のうち、術前に顔面神経麻痺を認めていた5例を対象とし、「術前の柳原スコア」「術前の鼓膜・耳内所見」「麻痺発症から手術までの期間」「術式」「術中所見」「術後の柳原スコア」「病的共同運動の有無」「術前後の聴力」などについて検討した。男性3例、女性2例、年齢は45～83歳であった。術前の柳原スコアは2～38点で、完全麻痺が2例、不完全麻痺3例であった。術前の鼓膜・耳内所見は、3例は外耳道が腫脹していたため鼓膜を観察できず、膿性耳漏を伴っていた。2例は弛緩部型真珠腫で、硬いdebrisの貯留を認めた。発症から手術までの期間は1週間以内が3例、約1ヵ月が2例で、1週間以内に手術した症例はいずれも柳原スコアが40点まで改善し、病的共同運動も軽度もしくは認めなかった。発症後約1ヵ月で手術した2例のうち、不完全麻痺の1例は軽度の病的共同運動、完全麻痺の1は中等度の病的共同運動を認めた。術式は、4例に一期的な外耳道後壁削除型鼓室形成術を施行した。残りの1例は45歳と若く、外耳道後壁保存型鼓室形成術で段階手術とした。術後の聴力は5例とも術前とほとんど変わらなかった。

  日本顔面神経学会, Jan. 2024, Facial Nerve Research, 43, 198 - 200, Japanese


• Verification of Criteria for Bilateral Cochlear Implantation for Adults at Our Hospital

  岩城忍, 柿木章伸, 藤田岳, 上原奈津美, 横井純, 丹生健一

  (一社)日本聴覚医学会, Dec. 2023, Audiology Japan, 66(6) (6), 544 - 551, Japanese


• ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese


• コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese


• 外耳道に挿入する耳科内視鏡ロボットの初期位置を決める画像認識手法

  奥家 拓海, 河合 俊和, 西川 敦, 藤田 岳, 上原 奈津美, 山下 俊彦, 鈴木 寿

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 165 - 165, Japanese


• 内視鏡下耳科手術支援ロボットの自律化に向けた深層学習を用いた複数手術器具検出

  丸川 可南子, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 178 - 178, Japanese


• ピボット点を切り替える斜交関節を備えた耳科用内視鏡マニピュレータ

  伊澤 樹哉, 河合 俊和, 藤田 岳, 上原 奈津美, 山下 俊彦, 西川 敦, 鈴木 寿

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 227 - 227, Japanese


• 内視鏡下耳科手術支援ロボット制御に向けた術者の姿勢・動作の画像解析

  西田 周誠, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Nov. 2023, 日本コンピュータ外科学会誌, 25(3) (3), 242 - 242, Japanese


• 外耳癌 診断から治療・術後管理まで 耳科手術専門医が知っておきたい技術 外側側頭骨切除術の適応と実際

  藤田 岳

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 39 - 39, Japanese


• ミトコンドリアDNA変異症例の臨床的特徴と聴覚障害の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 106 - 106, Japanese


• コハク酸脱水素酵素サブユニットB(SDHB)変異を伴った多発性頭頸部傍神経節腫の1例

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2023, 日本耳科学会総会・学術講演会抄録集, 33回, 353 - 353, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)による外耳道異物の1例

  繁治 純, 藤田 岳, 安井 理絵

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 308 - 308, Japanese


• ミトコンドリア病母体から出生した児の臨床症状に関する検討

  上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese


• 放射線誘発前庭障害をきたした外耳道癌症例

  横井 純, 山下 俊彦, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2023, Equilibrium Research, 82(5) (5), 505 - 505, Japanese


• 吸水性合成樹脂製玩具(水で膨らむボール)による外耳道異物の1例

  繁治 純, 藤田 岳, 安井 理絵

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 308 - 308, Japanese


• ミトコンドリア病母体から出生した児の臨床症状に関する検討

  上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Oct. 2023, 小児耳鼻咽喉科, 44(2) (2), 332 - 332, Japanese


• 高齢者における人工内耳の装用効果

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2023, Audiology Japan, 66(5) (5), 330 - 330, Japanese


• 腫瘍茎部が消失していた外耳道骨腫の1例

  中居 薫花, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 66 - 66, Japanese


• 人工内耳装用により認知機能検査のスコアが改善した高齢者の1例

  上坂 紗貴子, 岩城 忍, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  耳鼻咽喉科臨床学会, Jun. 2023, 耳鼻咽喉科臨床 補冊, (補冊161) (補冊161), 139 - 139, Japanese


• 日本耳鼻咽喉科頭頸部外科学会 働き方改革に関するWG報告 働き方改革に関するアンケート結果

  櫻井 結華, 藤田 岳, 森田 由香, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese


• 日耳鼻若手会員・基幹施設への出産・育児に関するアンケート調査結果(働き方改革に関するWG報告)

  藤田 岳, 森田 由香, 松延 毅, 丸山 裕美子, 櫻井 結華, 吉川 衛, 角南 貴司子, 小林 一女, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023, 日本耳鼻咽喉科頭頸部外科学会会報, 126(4) (4), 555 - 555, Japanese


• Endoscopic manipulator with pivot movable mechanism

  伊澤樹哉, 河合俊和, 藤田岳, 上原奈津美, 山下俊彦, 西川敦, 鈴木寿

  2023, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2023


• Image Analysis of Surgeon’s Posture and Movement for Controlling Assistant Robots in Transcanal Endoscopic Ear Surgery

  西田周誠, 松居和寛, 厚海慶太, 厚海慶太, 藤田岳, 上原奈津美, 山下俊彦, 河合俊和, 鈴木寿, 谷口和弘, 谷口和弘, 平井宏明, 西川敦

  2023, 日本コンピュータ外科学会誌(Web), 25(3) (3)


• Endoscope Ear Manipulator with Adjustable Diagonal Joints to Switch Pivot Point for Otologic Surgery

  伊澤樹哉, 河合俊和, 藤田岳, 上原奈津美, 山下俊彦, 西川敦, 鈴木寿

  2023, 日本コンピュータ外科学会誌(Web), 25(3) (3)


• Detection of Multiple Surgical Instruments Using Deep Learning for Autonomous Endoscopic Ear Surgery Assistant Robot

  丸川可南子, 松居和寛, 厚海慶太, 厚海慶太, 藤田岳, 上原奈津美, 山下俊彦, 河合俊和, 鈴木寿, 谷口和弘, 谷口和弘, 平井宏明, 西川敦

  2023, 日本コンピュータ外科学会誌(Web), 25(3) (3)


• Image recognition of external auditory canal for controlling ear endoscope robot

  奥家拓海, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 山下俊彦, 鈴木寿

  2023, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2023


• Image Recognition Method for Controlling Initial Position and Attitude of Ear Endoscope Robot Through into External Auditory Canal

  奥家拓海, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 山下俊彦, 鈴木寿

  2023, 日本コンピュータ外科学会誌(Web), 25(3) (3)


• 両側同時人工内耳植込み術後の前庭機能について

  横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2022, Equilibrium Research, 81(5) (5), 469 - 469, Japanese


• 人工聴覚器の適応:迷う症例にどう対応するか 人工中耳(VSB:Vibrant Soundbridge)に迷う症例

  藤田 岳

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 25 - 25, Japanese


• 耳科手術とQOLワーキンググループ 耳科手術とQOLに関する調査

  神崎 晶, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 細谷 誠, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 73 - 73, Japanese


• 遅発性感音難聴患者における聴力型から見た遺伝学的背景の検討

  上原 奈津美, 藤田 岳, 横井 純, 西尾 信哉, 宇佐美 真一, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 138 - 138, Japanese


• ミトコンドリアDNA7445A>G変異による難聴及び掌蹠角化症を認めた2例

  稲田 幸歩, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 170 - 170, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 邦訳版QOL質問票(SF36,SSQ12,COMQ12,SPOT25,NCIQ)を用いた検討(第2報)

  村田 大和, 細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 神崎 晶

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 290 - 290, Japanese


• 中耳髄膜腫の一例

  庄司 夢, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 309 - 309, Japanese


• 経外耳道的内視鏡下手術(TEES)で摘出し得たグロムス腫瘍症例

  小西池 佑一, 藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 310 - 310, Japanese


• 手術とデノスマブによるアジュバント療法を施行した側頭骨骨巨細胞腫の1例

  横井 純, 柿木 章伸, 上原 奈津美, 藤田 岳, 丹生 健一

  (一社)日本耳科学会, Oct. 2022, 日本耳科学会総会・学術講演会抄録集, 32回, 393 - 393, Japanese


• 成人における両側人工内耳手術の適応に関する検討(第一報)

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2022, Audiology Japan, 65(5) (5), 430 - 430, Japanese


• 内視鏡下耳科手術支援ロボット制御のための深層学習を用いた手術器具セグメンテーション

  堀ノ内 琢磨, 松居 和寛, 厚海 慶太, 藤田 岳, 上原 奈津美, 山下 俊彦, 河合 俊和, 鈴木 寿, 谷口 和弘, 平井 宏明, 西川 敦

  (一社)日本コンピュータ外科学会, Jun. 2022, 日本コンピュータ外科学会誌, 24(2) (2), 126 - 126, Japanese


• A Case of Steven-Johnson Syndrome Induced by Nivolumab

  廣田菜々子, 鈴木緑, 加藤麻衣子, 柳原茂人, 遠藤英樹, 大磯直毅, 川田暁, 大塚篤司, 田中薫, 藤田岳

  日本皮膚科学会-大阪地方会・京滋地方会, Mar. 2022, 皮膚の科学, 21(1) (1), 1 - 5, Japanese


• 進行聴器癌に対するDocetaxel,Cisplatin,5-FU同時併用化学放射線療法の有効性および有害事象に対する検討

  山田晃大, 四宮弘隆, 手島直則, 藤田岳, 上原奈津美, 柿木章伸, 丹生健一

  2022, 日本耳鼻咽喉科頭頚部外科学会会報, 125(4) (4)


• 内視鏡下耳科手術を支援する内視鏡テレオペレーションシステム

  伊澤樹哉, 河合俊和, 岡田史香, 原継真, 藤田岳, 上原奈津美, 西川敦, 鈴木寿

  2022, 日本ロボット学会学術講演会予稿集(CD-ROM), 40th


• 人工中耳(VSB:Vibrant Soundbridge)に迷う症例

  藤田岳

  2022, 日本耳科学会総会・学術講演会(Web), 32nd


• Endoscope Linear Teleoperation System in the External Auditory Canal

  伊澤樹哉, 河合俊和, 藤田岳, 上原奈津美, 西川敦, 鈴木寿

  2022, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2022


• Endoscope Linear Motion System with Ultrasonic Motor and Gearless DC Motor for Transcanal Endoscopic Ear Surgery

  横山健太, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 鈴木寿

  2022, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2022


• Surgical Instrument Segmentation Using Deep Learning for Control of Transcanal Endoscopic Ear Surgical Assistant Robots

  堀ノ内琢磨, 松居和寛, 厚海慶太, 厚海慶太, 藤田岳, 上原奈津美, 山下俊彦, 河合俊和, 鈴木寿, 谷口和弘, 谷口和弘, 平井宏明, 西川敦

  2022, 日本コンピュータ外科学会誌(Web), 24(2) (2)


• Endoscope manipulator with Gimbal mechanism Driven by Ultrasonic Motor and DC Motor for Transcanal Endoscopic Ear Surgery

  横山健太, 河合俊和, 西川敦, 藤田岳, 上原奈津美, 鈴木寿

  2022, 計測自動制御学会システムインテグレーション部門講演会(CD-ROM), 23rd


• A case of facial schwannoma with extensive destruction and infiltration of the temporal bone: Strategies and challenges for radical resection

  下田光, 柿木章伸, 横井純, 上原奈津美, 藤田岳, 橋川和信, 木村英仁, 丹生健一

  30歳男性。左顔面神経麻痺、左難聴を主訴とした。CT、MRIで側頭骨内の腫瘍の広範囲な進展・破壊・浸潤を認め、中頭蓋窩、内頸動脈周囲へ進展した腫瘍は内耳道内、前庭、蝸牛内を占拠していた。生検より顔面神経鞘腫と診断した。聴力・平衡機能の低下があり顔面神経麻痺スコア20点以下であったため根治手術適応と考え、中頭蓋窩および経迷路法で顔面神経鞘腫摘出および腓腹神経再建を行った。

  日本顔面神経学会, 2022, Facial Nerve Research Japan, 41, 59 - 61, Japanese


• 低侵襲人工内耳植込み術後の前庭機能について(第3報)

  横井 純, 柳沢 俊学, 梶本 康幸, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2021, Equilibrium Research, 80(5) (5), 482 - 482, Japanese


• 人工聴覚器手術 症例登録システムWG 2021年度活動報告

  土井 勝美, 岩崎 聡, 大崎 康宏, 伊藤 卓, 白井 杏湖, 藤田 岳, 吉田 晴郎, 新規医療委員会人工聴覚器手術-症例登録システムWG

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 122 - 122, Japanese


• 耳科手術とQOLに関する調査

  神崎 晶, 細谷 誠, 我那覇 章, 吉村 豪兼, 森田 由香, 松本 希, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 国内学術委員会耳科手術とQOLワーキンググループ

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 125 - 125, Japanese


• 一側性聴神経腫瘍症例における蝸牛内のMRI信号強度

  藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 187 - 187, Japanese


• 当科におけるグロムス腫瘍18例の治療方針の検討

  横井 純, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 199 - 199, Japanese


• ミトコンドリアDNA3243A>G変異によるミトコンドリア病の1家系

  上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 265 - 265, Japanese


• 聴力改善手術が患者QOLに及ぼす影響 邦訳版QOL質問票(SF36、SSQ12、COMQ12、SPOT25、NCIQ)を用いた検討

  西村 洸一郎, 細谷 誠, 我那覇 章, 森田 由香, 松本 希, 吉村 豪兼, 藤田 岳, 白井 杏湖, 赤井 亮, 伊藤 吏, 土井 勝美, 高橋 優宏, 高橋 昌寛, 平海 晴一, 高橋 真理子, 岡田 昌浩, 山内 大輔, 美内 慎也, 山本 典生, 池園 哲郎, 小森 学, 綾仁 悠介, 樫尾 明憲, 宇佐美 真一, 東野 哲也, 中川 尚志, 萩森 伸一, 神崎 晶

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 269 - 269, Japanese


• キヌタ骨が乳突洞内に脱出した外傷性耳小骨離断の1例

  遠藤 侑未, 上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2021, 日本耳科学会総会・学術講演会抄録集, 31回, 385 - 385, Japanese


• 高齢者における人工内耳装用後の聴取成績の経過について

  岩城 忍, 横井 純, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Sep. 2021, Audiology Japan, 64(5) (5), 466 - 466, Japanese


• 色素性乾皮症の聴力障害

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 163 - 163, Japanese


• Pseudo-dominant遺伝形式を示すGJB2遺伝子変異が検出された先天性難聴児の1例

  橋本 裕依子, 上原 奈津美, 岩城 忍, 藤田 岳, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Jun. 2021, 小児耳鼻咽喉科, 42(2) (2), 190 - 190, Japanese


• 好酸球中耳炎の中耳貯留液における脂質メディエーターの解析

  藤田 岳, 横井 純, 上原 奈津美, 井之口 豪, 後藤 友佳子, 土井 勝美, 柿木 章伸, 篠原 正和, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 605 - 605, Japanese


• ミトコンドリア病による成人難聴症例の検討

  上原 奈津美, 藤田 岳, 横井 純, 柿木 章伸, 丹生 健一

  (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2021, 日本耳鼻咽喉科学会会報, 124(4) (4), 639 - 639, Japanese


• 【術前画像と術中解剖-カンファレンスで突っ込まれないための知識】耳領域 耳介・外耳道病変に対する手術

  藤田 岳, 柿木 章伸

  (株)医学書院, Apr. 2021, 耳鼻咽喉科・頭頸部外科, 93(5) (5), 006 - 011, Japanese


• 当科における顔面神経鞘腫23例の検討

  下田 光, 柿木 章伸, 横井 純, 上原 奈津美, 藤田 岳, 丹生 健一, 橋川 和信, 甲村 英二

  顔面神経鞘腫の治療において村上らが提唱した治療アルゴリズムは、顔面神経麻痺の程度が主な基準となり、柳原法で20点未満が外科的介入の対象となるが、病変が頭蓋内に進展している例や随伴症状によっては20点以上であっても根治切除を行うことがある。一方、20点未満であっても患者背景やQOLを考慮して経過観察や放射線治療を選択する場合もある。今回、当科で2005〜2020年に顔面神経鞘腫と診断した23例の治療アルゴリズムを後方視的に検討した。側頭骨内顔面神経鞘腫22例のうち、麻痺スコア20点未満の10例中8例に手術治療を選択し、8例とも全摘術を行っていた。麻痺スコア20点以上の症例では12例中9例に手術治療を選択しており、経過観察は3例のみであった。腫瘍切除後は全例に即時的再建を行っていた。術後1年以上の経過が追えた9例について再建後の麻痺スコアの推移をみると、術後1年以降の平均スコアは13.4点で、8点以下が2例、10〜18点が1例、20点以上が6例であった。

  日本顔面神経学会, Mar. 2021, Facial Nerve Research, 40, 197 - 201, Japanese


• 低侵襲人工内耳埋め込み術後の前庭機能について

  横井 純, 柳沢 俊学, 柿木 章伸, 藤田 岳, 岩城 忍, 梶本 康幸, 丹生 健一

  周術期にステロイドを投与し、正円窓アプローチで低浸潤人工内耳埋め込み術を行った10例を対象に、術前、術後1〜6ヵ月、術後1年にめまい症状、聴力、平衡機能を検査した。めまいの症状の有無は診療録に記載のあるものをめまい症状ありと定義した。平衡機能の検査として、眼振検査、温度刺激検査、前庭誘発筋電位検査、重心動揺検査を行った。聴力については、4分法平均聴力と低音部聴力の平均について集計し、4分法と低音部それぞれでの術前後の差を検証した。その結果、前庭誘発筋電位検査における前庭誘発頸筋電位で半数近くの症例で術後に増悪を認めた。その他の検査では術前後で明らかな増悪を認めなかった。

  (一社)日本めまい平衡医学会, Feb. 2021, Equilibrium Research, 80(1) (1), 31 - 40, Japanese


• 経外耳道的直達外傷による小児迷路気腫の1例

  上紺屋 達彦, 藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  日本小児耳鼻咽喉科学会, Nov. 2020, 小児耳鼻咽喉科, 41(2) (2), 202 - 202, Japanese


• 外側側頭骨切除術時に皮膚管を用いた一期的外耳道・伝音再建

  藤田 岳, 横井 純, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 164 - 164, Japanese


• 成人症例における難聴遺伝子解析の検討

  上原 奈津美, 横井 純, 藤田 岳, 柿木 章伸, 丹生 健一, 西尾 信哉, 宇佐美 真一

  (一社)日本耳科学会, Nov. 2020, 日本耳科学会総会・学術講演会抄録集, 30回, 277 - 277, Japanese


• 人工内耳埋め込み術後の重心動揺検査の検討(第一報)

  横井 純, 柳沢 俊学, 柿木 章伸, 岩城 忍, 藤田 岳, 丹生 健一

  (一社)日本めまい平衡医学会, Oct. 2020, Equilibrium Research, 79(5) (5), 456 - 456, Japanese


• ステロイド加療を行い一時的に聴力が改善した聴神経腫瘍症例の検討

  白石 功, 小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 444 - 444, Japanese


• 色素性乾皮症の聴力障害とモデルマウスの聴覚解析

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese


• 音響障害よる内耳外リンパのサイトカインの変化

  藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 441 - 441, Japanese


• 人工知能を用いた術後聴力予測システムの開発

  小山 一, 奥野 妙子, 畑 裕子, 森 安仁, 齋藤 和也, 大崎 康宏, 藤田 岳, 山岨 達也, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 111 - 111, Japanese


• TEESが有用であった両側先天性真珠腫に対する同時手術の2例

  上田 隆, 由井 光子, 赤澤 亜由, 上原 奈津美, 藤田 岳, 後藤 友佳子, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 207 - 207, Japanese


• ステロイド加療を行い一時的に聴力が改善した聴神経腫瘍症例の検討

  白石 功, 小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 444 - 444, Japanese


• 色素性乾皮症の聴力障害とモデルマウスの聴覚解析

  藤田 岳, 上原 奈津美, 柿木 章伸, 丹生 健一

  (一社)日本耳科学会, Oct. 2019, 日本耳科学会総会・学術講演会抄録集, 29回, 471 - 471, Japanese


• 音響障害よる内耳外リンパのサイトカインの変化

  藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 441 - 441, Japanese


• 両側同時人工内耳植え込み術を施行した両側内耳破壊の一症例

  岩城 忍, 上原 奈津美, 藤田 岳, 柿木 章伸, 丹生 健一

  (一社)日本聴覚医学会, Oct. 2019, Audiology Japan, 62(5) (5), 502 - 502, Japanese


• 【聴神経腫瘍診療の未来】聴神経腫瘍の基礎研究と遺伝子解析

  藤田 岳, 土井 勝美

  (一社)日本耳科学会, May 2019, Otology Japan, 29(2) (2), 137 - 141, Japanese


• 前庭神経機能の評価におけるカロリック検査、vHIT検査およびVEMP検査の関連性について

  白石 功, 小林 孝光, 藤田 岳, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 652 - 652, Japanese


• VSB術後成績における予後因子の検討

  小山 一, 藤田 岳, 齋藤 和也, 大崎 康宏, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 643 - 643, Japanese


• 前庭神経機能の評価におけるカロリック検査、vHIT検査およびVEMP検査の関連性について

  白石 功, 小林 孝光, 藤田 岳, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2019, 日本耳鼻咽喉科学会会報, 122(4) (4), 652 - 652, Japanese


• 当科における小児先天性耳小骨奇形の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  日本小児耳鼻咽喉科学会, Jun. 2018, 小児耳鼻咽喉科, 39(2) (2), 158 - 158, Japanese


• 残存聴力活用型人工内耳(EAS)適応聴力患者の検討

  齋藤 和也, 堀口 生茄, 小林 孝光, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 522 - 522, Japanese


• メニエール病におけるカロリックテストとvHITの結果の乖離に関する検討

  瀬尾 徹, 小林 孝光, 白石 功, 藤田 岳, 北野 睦三, 齋藤 和也, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 561 - 561, Japanese


• 一側聾となった前庭内の小聴神経鞘腫の1例

  佐藤 満雄, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2018, 日本耳鼻咽喉科学会会報, 121(4) (4), 617 - 617, Japanese


• 人工内耳埋め込み術後に生じた顔面痙攣の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  日本顔面神経学会, Feb. 2018, Facial Nerve Research, 37, 98 - 100, Japanese


• 人工内耳埋め込み術後に生じた顔面痙攣の検討

  齋藤 和也, 小林 孝光, 藤田 岳, 土井 勝美

  2010年4月〜2017年1月に当科で人工内耳埋め込み術を施行した176耳のうち、音入れ後に顔面けいれんを認めた20例(男性11例、女性9例、中央値48歳)21耳について検討した。難聴の原因疾患は、原因不明が12例、CHARGE連合が4例、内耳奇形が1例、蝸牛型耳硬化症が1例、neurofibromatosis type 1(NF-I)が1例、Down症が1例であった。けいれん部位は眼瞼が66.7%、頬部が9.5%、口角が38.1%(複数ヶ所含む)であり、眼瞼に最も多く認めた。顔面けいれんを認めた際の対応であるが、15耳はマップの調整でけいれんは消失し、聴取能に影響することはなかった。一方で、6耳はマップの調整でも十分な聴取能を得ることができなかった。15耳の内訳を疾患別でみると、原因不明(蝸牛形態に異常を認めないもの)が13耳と最も多く、蝸牛型耳硬化症とCHARGE連合がそれぞれ1耳ずつであり、術前の画像検査でCHARGE連合の1耳に蝸牛神経管狭窄が認められた。一方、6耳の内訳はCHARGE連合が3耳、内耳奇形が1耳、NF-Iが1耳、Down症が1耳であった。

  日本顔面神経学会, Feb. 2018, Facial Nerve Research, 37, 98 - 100, Japanese


• 上前庭神経障害の評価に関する検討

  白石 功, 瀬尾 徹, 小林 孝光, 藤田 岳, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2017, Equilibrium Research, 76(5) (5), 486 - 486, Japanese


• めまいと難聴を主訴とした小脳悪性リンパ腫の1例

  白石 功, 藤田 岳, 小林 孝光, 瀬尾 徹, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2017, Equilibrium Research, 76(5) (5), 546 - 546, Japanese


• メニエール病非定型例(蝸牛型)の病態に関する考察 フロセミド負荷VEMPによる検討

  瀬尾 徹, 白石 功, 小林 功, 藤田 岳, 斎藤 和也, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 505 - 505, Japanese


• 鼓膜形成後の聴力経過 術式による違い

  齋藤 和也, 磯野 道夫, 小林 孝光, 藤田 岳, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 601 - 601, Japanese


• 中耳奇形に合併した内耳瘻孔例

  小林 孝光, 藤田 岳, 齋藤 和也, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 637 - 637, Japanese


• 突発性難聴患者に聴神経腫瘍が発見された頻度

  藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Oct. 2017, Otology Japan, 27(4) (4), 657 - 657, Japanese


• 術後MRSA感染により再手術をおこなった人工内耳症例

  森川 大樹, 藤田 岳, 齋藤 和也, 土井 勝美

  日本耳鼻咽喉科感染症・エアロゾル学会, Sep. 2017, 日本耳鼻咽喉科感染症・エアロゾル学会会誌, 5(3) (3), 66 - 66, Japanese


• 人工内耳電極の長さの違いによる、低周波数域の聴力温存の検討

  藤田 岳, 齋藤 和也, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 291 - 291, Japanese


• 当科におけるVIBRANT SOUNDBRIDGE(VSB)装用患者の聴取成績経過

  長富 大祐, 藤田 岳, 齋藤 和也, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 317 - 317, Japanese


• 耳鳴に対し補聴器による音響療法を行った9例

  小林 孝光, 藤田 岳, 齋藤 和也, 新田 清一, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2017, Audiology Japan, 60(5) (5), 403 - 403, Japanese


• いわゆるlight cupula症の耳石器機能

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 北野 睦三, 土井 勝美

  耳鼻咽喉科ニューロサイエンス研究会, May 2017, 耳鼻咽喉科ニューロサイエンス, 31, 13 - 15, Japanese


• いわゆるlight cupula症の耳石器機能

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 北野 睦三, 土井 勝美

  いわゆるlight cupula症と診断された14例を対象に、前庭機能検査として温度刺激検査、cVEMPおよびoVEMPを施行した。いわゆるlight cupula症の診断は、既報に依った。温度刺激検査は20℃20秒刺激を用い、VOGによる最大緩徐相速度で評価した。また、cVEMPおよびoVEMPの記録法と判定法は既報に従った。その結果、oVEMPの異常は11例に、cVEMPの異常は4例に認めた。以上より、いわゆるlight cupula症は耳石器、とくに卵形嚢の異常と関連している可能性が示唆された。

  耳鼻咽喉科ニューロサイエンス研究会, May 2017, 耳鼻咽喉科ニューロサイエンス, 31, 13 - 15, Japanese


• 外耳道経由で正円窓へのアプローチを目指した、ヒト側頭骨標本の解剖学的検討

  藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 522 - 522, Japanese


• 当科で経験した残存聴力活用型人工内耳手術症例の成績

  齋藤 和也, 小林 孝光, 白石 功, 西原 美沙子, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 526 - 526, Japanese


• 耳石器障害めまい患者の重心動揺

  小林 孝光, 白石 功, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 667 - 667, Japanese


• 外耳道経由で正円窓へのアプローチを目指した、ヒト側頭骨標本の解剖学的検討

  藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 522 - 522, Japanese


• 当科で経験した残存聴力活用型人工内耳手術症例の成績

  齋藤 和也, 小林 孝光, 白石 功, 西原 美沙子, 佐藤 満雄, 藤田 岳, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 526 - 526, Japanese


• 耳石器障害めまい患者の重心動揺

  小林 孝光, 白石 功, 藤田 岳, 齋藤 和也, 瀬尾 徹, 土井 勝美

  (一社)日本耳鼻咽喉科学会, Apr. 2017, 日本耳鼻咽喉科学会会報, 120(4) (4), 667 - 667, Japanese


• いわゆるlight cupula型頭位眼振症例の耳石器機能

  藤田 岳, 瀬尾 徹, 白石 功, 小林 孝光, 北野 睦三, 土井 勝美

  (一社)日本めまい平衡医学会, Oct. 2016, Equilibrium Research, 75(5) (5), 436 - 436, Japanese


• 児の感染を契機に発覚した両親の咽頭梅毒

  森川 大樹, 齋藤 和也, 藤田 岳, 土井 勝美

  日本耳鼻咽喉科感染症・エアロゾル学会, Sep. 2016, 日本耳鼻咽喉科感染症・エアロゾル学会会誌, 4(3) (3), 54 - 54, Japanese


• 人工内耳埋め込み術をおこなったOMAAVの一例

  齋藤 和也, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本聴覚医学会, Sep. 2016, Audiology Japan, 59(5) (5), 363 - 364, Japanese


• フロセミド負荷VEMP メニエール病のめまい発作の発現機序に関する考察

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 小泉 敏三, 齋藤 和也, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 287 - 287, Japanese


• 当院におけるパッチテストと鼓膜形成術について

  齋藤 和也, 磯野 道夫, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 362 - 362, Japanese


• 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害

  藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese


• 顔面神経減荷術施行34症例の検討

  小泉 敏三, 齋藤 和也, 小林 孝光, 藤田 岳, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 598 - 598, Japanese


• 当科におけるウイルス性を除いた顔面神経麻痺症例の検討

  木村 隆幸, 藤田 岳, 小泉 敏三, 齋藤 和也, 磯野 道夫, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 601 - 601, Japanese


• 高度難聴が著明に改善した外リンパ瘻の1例

  小林 孝光, 藤田 岳, 齋藤 和也, 小泉 敏三, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 619 - 619, Japanese


• フロセミド負荷VEMP メニエール病のめまい発作の発現機序に関する考察

  瀬尾 徹, 白石 功, 小林 孝光, 藤田 岳, 小泉 敏三, 齋藤 和也, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 287 - 287, Japanese


• 当院におけるパッチテストと鼓膜形成術について

  齋藤 和也, 磯野 道夫, 小林 孝光, 佐藤 満雄, 藤田 岳, 小泉 敏三, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 362 - 362, Japanese


• 聴神経腫瘍から分泌される細胞外小胞(エクソソーム)による蝸牛障害

  藤田 岳, 柿木 章伸, 丹生 健一, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 482 - 482, Japanese


• 顔面神経減荷術施行34症例の検討

  小泉 敏三, 齋藤 和也, 小林 孝光, 藤田 岳, 磯野 道夫, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 598 - 598, Japanese


• 当科におけるウイルス性を除いた顔面神経麻痺症例の検討

  木村 隆幸, 藤田 岳, 小泉 敏三, 齋藤 和也, 磯野 道夫, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 601 - 601, Japanese


• 高度難聴が著明に改善した外リンパ瘻の1例

  小林 孝光, 藤田 岳, 齋藤 和也, 小泉 敏三, 瀬尾 徹, 土井 勝美

  (一社)日本耳科学会, Sep. 2016, Otology Japan, 26(4) (4), 619 - 619, Japanese


• Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明

  井之口 豪, 薛 富義, 吉川 知志, 寺島 俊雄, 四宮 瞳, 藤田 岳, 山下 大介, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 20 - 22, Japanese


• Dab1遺伝子異常マウスにおけるオリーブ蝸牛束の構築異常の解明

  井之口 豪, 薛 富義, 吉川 知志, 寺島 俊雄, 四宮 瞳, 藤田 岳, 山下 大介, 丹生 健一

  耳鼻咽喉科ニューロサイエンス研究会, May 2016, 耳鼻咽喉科ニューロサイエンス, 30, 20 - 22, Japanese


• 耳下腺上皮筋上皮癌の2例

  小嶋 康隆, 雲井 一夫, 井之口 豪, 小松 弘和, 藤田 岳, 澤田 直樹, 栃谷 奈央, 甲藤 麻衣, 橋本 公夫

  (一社)日本耳鼻咽喉科学会, Apr. 2016, 日本耳鼻咽喉科学会会報, 119(4) (4), 675 - 675, Japanese


• 前庭症状を主訴とした症例での簡易温度刺激検査の年代別検討

  Inokuchi Gou, Fujita Takeshi

  Nov. 2015, 第73回日本めまい平衡医学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 外耳道後壁削除型鼓室形成術に併施した骨パテによる乳突腔部分充填術後症例の検討

  上原 奈津美, 後藤 友佳子, 長谷川 信吾, 香山 智佳子, 越智 尚樹, 藤田 岳, 小嶋 康隆, 山本 沙織

  (一社)日本耳科学会, Sep. 2015, Otology Japan, 25(4) (4), 635 - 635, Japanese


• 耳かきによる外傷性耳小骨離断の陳旧例2症例

  畑 裕子, 堤内 亮博, 山本 沙織, 藤田 岳, 一瀬 和美, 立川 麻也子, 宇野 真莉子, 松本 有, 小嶋 康隆, 奥野 妙子

  (一社)日本耳科学会, Jul. 2015, Otology Japan, 25(3) (3), 260 - 268, Japanese


• 軟素材による外耳道後壁再建を行った後天性真珠腫症例の検討

  柴田 智久, 藤田 岳, 小嶋 康隆, 井之口 豪, 山下 大介, 長谷川 信吾, 丹生 健一

  (一社)日本耳鼻咽喉科学会, Apr. 2015, 日本耳鼻咽喉科学会会報, 118(4) (4), 482 - 482, Japanese


• 前庭症状を主訴とした症例での簡易温度刺激検査の年代別検討

  畑 裕子, 山崎 葉子, 堤内 亮博, 山本 沙織, 崎谷 恵理, 一瀬 和美, 馬場 美雪, 松本 有, 小嶋 康隆, 井之口 豪, 藤田 岳, 奥野 妙子

  (一社)日本めまい平衡医学会, Oct. 2014, Equilibrium Research, 73(5) (5), 400 - 400, Japanese


• 色素性乾皮症における聴覚障害の検討

  Yamashita Daisuke, Fujita Takeshi, Inokuchi Gou, Hasegawa Shingo, Nibu Ken-ichi

  Oct. 2014, 第24回日本耳科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 溶連菌による成人急性中耳炎の2症例

  Fujita Takeshi

  Oct. 2014, 第24回日本耳科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 色素性乾皮症における聴覚障害の検討

  山下 大介, 藤田 岳, 井之口 豪, 長谷川 信吾, 丹生 健一

  (一社)日本耳科学会, Sep. 2014, Otology Japan, 24(4) (4), 487 - 487, Japanese


• 溶連菌による成人急性中耳炎の2症例

  畑 裕子, 堤内 亮博, 山本 沙織, 崎谷 恵理, 藤田 岳, 一瀬 和美, 奥野 妙子

  (一社)日本耳科学会, Sep. 2014, Otology Japan, 24(4) (4), 670 - 670, Japanese


• 前庭症状を主訴とした症例の年代別特徴について(第2報)

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 中耳真珠腫における乳突蜂巣発育程度および含気腔

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 先天性真珠腫の成人例

  Inokuchi Gou, Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 耳下腺に浸潤した外毛根鞘癌の一例

  Inokuchi Gou, Komatsu Hirokazu, Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 中耳真珠腫進展度分類2010改訂案中のアブミ骨病変の程度に基づいた真珠腫性中耳炎自験例の検討

  Fujita Takeshi

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• 手術治療が有効であったPlummer病の1例

  Fujita Takeshi, Inokuchi Gou

  May 2014, 第115回日本耳鼻咽喉科学会総会・学術講演会, Japanese

  [Invited]

  Summary national conference


• Hearing loss in Xeroderma pigmnetosum and mechanism of inner ear disorder.

  Yamashita Daisuke, Fujita Takeshi, Masaki Taro, Takeuchi Seiji, Ueda Takehiro, Sakai Yoshitada, Nakagawa Taku, Toyoshima Daisaku, Morisada Naoya, Kanda Fumio, Nishigori Chikako

  Mar. 2014, International Symposium on Xeroderma Pigmentosum and Related Disease, English

  Summary national conference


• 乳突蜂巣内を走行するpetrosquamosal sinus

  Inokuchi Gou, Komatsu Hirokazu, Fujita Takeshi

  Nov. 2013, The 23th Annual Meeting of the Japan Otological Society, Japanese

  [Invited]

  Summary national conference


• 【急患・急変対応マニュアル-そのとき必要な処置と処方】 術中・術後の急変への対応法 術後編 耳科手術後の髄液漏

  藤田 岳, 奥野 妙子

  (株)医学書院, Apr. 2013, 耳鼻咽喉科・頭頸部外科, 85(5) (5), 332 - 335, Japanese


• AIDS患者の中咽頭扁平上皮癌に対する治療経験

  Fujita Takeshi, Yoshida Kenji, Sasaki Ryohei, Ohtsuki Naoki, Nibu Ken-ichi

  Jun. 2012, 第36回日本頭頸部癌学会, Japanese

  [Invited]

  Summary national conference


• 患者の中咽頭扁平上皮癌に対する治療経験

  林 拓二, 藤田 岳, 吉田 賢史, 西村 英輝, 佐々木 良平, 大月 直樹, 丹生 健一

  (一社)日本頭頸部癌学会, May 2012, 頭頸部癌, 38(2) (2), 224 - 224, Japanese


• 内耳移植細胞の生体内動態モニタリング法の確立

  山下 大介, 和多田 有紀子, 神崎 晶, 藤田 岳, 長谷川 信吾, 小川 郁, 丹生 健一

  近年、感音難聴に対する治療戦略の一つとして幹細胞を用いた再生医療の基礎的研究が急速に発展しているが、移植した細胞の生体内動態をモニタリングする方法は未だ確立されていない。そこで著者等はモニタリング手段として、超常磁性体酸化鉄(SPIO)を造影剤に用いるMRI法に着目した。SPIOは肝Kupffer細胞に取り込まれるとT2緩和時間を短縮させ、MRI信号を低下させることが知られている。今回、SPIO製剤を用いて、まずin vitroにおける細胞内ラベリング効果を確認したのち、音響外傷モデルマウスにおいて、SPIOでラベリングした骨髄由来間葉系幹細胞を内耳移植した際の生体内動態について検討した。結果、SPIOでラベリングした幹細胞は内耳において移植後4週目までのその局在をMRIで確認することが可能であった。

  耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 7 - 9, Japanese


• 糖尿病モデルマウスにおける聴覚機能および内耳形態の検討

  藤田 岳, 山下 大介, 勝沼 紗矢香, 長谷川 信吾, 丹生 健一

  糖尿病と難聴の関係についてはこれまで多くの報告がなされているが、その評価は必ずしも一定していない。そこで今回、1型・2型の糖尿病モデルマウスを作製し、聴力機能と蝸牛形態の変化について検討した。結果、モデル作製後1ヵ月の時点では1型モデル・2型モデルともコントロール群に比べて聴力閾値が有意に高く、蝸牛形態は1型・2型ともコントロール群との間に明らかな差異は認めなかった。モデル作製後3ヵ月の時点では1型モデルにおいて聴力閾値がコントロー群より有意に高く、2型モデルにおいては刺激音32kHzでの聴力閾値がコントロール群より有意に低かった。蝸牛形態は1型モデルにおいて血管条の空胞化とラセン神経節細胞数の減少傾向を認め、2型モデルにおいてはコントロール群との間に明らかな差異は認めなかった。

  耳鼻咽喉科ニューロサイエンス研究会, Apr. 2011, 頭頸部自律神経, 25, 13 - 16, Japanese


• 音響外傷性難聴に対するSA4503の内耳防御機能

  山下 大介, 松永 達雄, 藤田 岳, 長谷川 信吾, 丹生 健一

  (一社)日本耳鼻咽喉科学会, Apr. 2010, 日本耳鼻咽喉科学会会報, 113(4) (4), 396 - 396, Japanese


• 小児口蓋扁桃摘出術における予防的抗菌薬投与の検討 : 術後7日間投与と術前1回投与の比較

  藤田 岳, 後藤 友佳子, 松元 雪絵, 越智 尚樹, 香山 智佳子, 小嶋 康隆, 長谷川 信吾, 丹生 健一

  01 Jun. 2009, 小児耳鼻咽喉科, 30(2) (2), 96 - 96, Japanese


• 小児上咽頭分離菌と反復性中耳炎症例の検討

  香山 智佳子, 後藤 友佳子, 越智 尚樹, 小嶋 康隆, 藤田 岳, 中上 佳美

  2004年から4年間に細菌検査を行った小児急性・反復性中耳炎567例(平均1.84歳)を対象とし、上咽頭分離菌と反復性中耳炎症例の検討を行った。検出菌は三大起因菌が92.8%を占めたが、インフルエンザ菌は年々増加傾向にあり、2006年以降は検出率・耐性化率とも肺炎球菌を超えていた。また、鼓膜チューブ留置術を要した反復性中耳炎12例はいずれも保育園児またはその同胞で、インフルエンザ菌が検出された8例のうち5例がBLNARであり、BLNAR以外の症例より中耳炎診断から鼓膜チューブ留置術までの期間が短い傾向にあった。小児の急性中耳炎においてはインフルエンザ菌、特にBLNARの増加が難治化の一因と推考され、BLNAR症例ではより早期の鼓膜チューブ留置術が必要と考えられた。

  日本耳鼻咽喉科感染症研究会, May 2009, 日本耳鼻咽喉科感染症研究会会誌, 27(1) (1), 117 - 121, Japanese


• Seven cases of adhesive cholesteatoma in children

  GOTO Yukako, OCHI Naoki, KAYAMA Chikako, HASEGAWA Shingo, FUJITA Takeshi, KOJIMA Yasutaka

  01 Mar. 2009, 小児耳鼻咽喉科, 30(1) (1), 54 - 60, Japanese


• 小児癒着型真珠腫症例の検討

  後藤 友佳子, 越智 尚樹, 小嶋 康隆, 香山 智佳子, 長谷川 信吾, 藤田 岳

  21 Jun. 2008, 小児耳鼻咽喉科, 29(2) (2), 44 - 44, Japanese


• 小児反復性中耳炎難治例

  香山 智佳子, 後藤 友佳子, 越智 尚樹, 小嶋 康隆, 藤田 岳

  21 Jun. 2008, 小児耳鼻咽喉科, 29(2) (2), 59 - 59, Japanese


• 口蓋扁桃摘出術における予防的抗菌薬投与の検討

  藤田岳

  2008, 日本耳鼻咽喉科感染症研究会会誌, 26(1) (1), 163 - 166


• 好酸球性中耳炎の聴力予後

  後藤 友佳子, 越智 尚樹, 藤田 岳, 香山 智佳子, 濱本 由記子, 長谷川 信吾

  22 Sep. 2007, Otology Japan, 17(4) (4), 449 - 449, Japanese


• 両側難聴と視力障害を呈したクリプトコッカス髄膜炎の一例

  藤田 岳, 後藤 友佳子, 越智 尚樹, 香山 智佳子

  22 Sep. 2007, Otology Japan, 17(4) (4), 383 - 383, Japanese


• 側頭部から頸部まで進展した咀嚼筋間隙膿瘍の一例

  藤田岳

  2007, 日耳鼻感染症研会誌, 25, 93 - 96


• 難治性MRSA感染耳に対するピオクタニン^【○!R】の治療経験

  香山 智佳子, 後藤 友佳子, 長谷川 信吾, 藤田 岳

  22 Sep. 2006, Otology Japan, 16(4) (4), 432 - 432, Japanese


• 鼓膜チューブ留置術による治療成績と合併症について : チューブ留置期間による検討

  長谷川 信吾, 後藤 友佳子, 藤田 岳, 香山 智佳子

  22 Sep. 2006, Otology Japan, 16(4) (4), 347 - 347, Japanese


• 好酸球性中耳炎に対するトリアムシノロンアセトニド(ケナコルトーA^【○!R】)中耳腔内投与の効果

  後藤 友佳子, 長谷川 信吾, 藤田 岳, 香山 智佳子

  22 Sep. 2006, Otology Japan, 16(4) (4), 389 - 389, Japanese

• Hearing Impairment in Xeroderma Pigmentosum: Animal Models and Human Studies

  FUJITA TAKESHI

  Joint work, 49-58, Springer Singapore, 2019, English

  Scholarly book

• テラヘルツ波を用いた甲状腺腫瘍に対する革新的診断技術の確立

  手島 直則, 芹田 和則, 上原 慶一郎, 藤田 岳

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2024 - 31 Mar. 2028

  テラヘルツ波は光の直進性と電波の透過性という両方の性質を持つ電磁波であり、工業的な非破壊検査に用いられている。このテラヘルツ波による分光イメージング技術を応用し、これまでの甲状腺腫瘍診断の課題を解決し得る、新しい診断方法の基盤となる技術の確立を目指すものである。テラヘルツ波は、ミリ波と遠赤外線の間の波長に位置する電磁波で、光の直進性と電波の透過性という両方の性質を持つ。工業的な非破壊検査などでこれまで用いられている。波長計測の難しさから生命・医療への応用が長年困難であったが、テラヘルツ波を利用した新しい方式の顕微鏡を開発し、これまでに0.5mm未満の小さな早期がんや細胞レベルでの非標識イメージングに成功している報告がある。甲状腺腫瘍の手術の際には腫瘍の組織型や進展範囲、リンパ節転移の状態を即時に診断できる検査としてテラヘルツ波を応用した甲状腺腫瘍の診断システム開発を目指すものである。


• 医工融合による低侵襲・高解像な感音難聴の精密診断の実現

  藤田 岳

  科学技術振興機構, 戦略的な研究開発の推進/創発的研究支援事業, 2022 - 2028

  空気の振動である「音」は、耳の奥にある内耳蝸牛で電気的な信号に変換されます。この蝸牛が障害されることにより、感音難聴が生じます。しかし、生きている人の蝸牛内部を直接観察する技術は存在せず、現在でも、目の前の患者さんの感音難聴の原因は分かりません。本研究では外科的な技能・知識と工学的テクノロジーの融合により、感音難聴の原因をリアルタイムに診断し、治療につながる画期的な技術の開発を目指します。


• 医工融合による低侵襲・高解像な感音難聴の精密診断の実現

  藤田 岳

  科学技術振興機構, 戦略的な研究開発の推進 創発的研究支援事業, 神戸大学, Apr. 2022 - 2028, Principal investigator

  空気の振動である「音」は、耳の奥にある内耳蝸牛で電気的な信号に変換されます。この蝸牛が障害されることにより、感音難聴が生じます。しかし、生きている人の蝸牛内部を直接観察する技術は存在せず、現在でも、目の前の患者さんの感音難聴の原因は分かりません。本研究では外科的な技能・知識と工学的テクノロジーの融合により、感音難聴の原因をリアルタイムに診断し、治療につながる画期的な技術の開発を目指します。


• The role of MMP14 in Vestibular Schwannoma and the development of novel treatments and diagnostic methods

  百束 紘, 大石 直樹, 和佐野 浩一郎, 都築 伸佳, 藤田 岳, 荒井 康裕

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Yokohama City University, Apr. 2024 - Mar. 2027

  聴神経腫瘍は、主要症状として感音難聴とめまいがあり、腫瘍の増大と共に顔面神経麻痺や三叉神経麻痺などの合併症が起き得る。治療法は手術による腫瘍の摘出または定位放射線治療があるが、手術の合併症として聴力の悪化、めまい、顔面神経麻痺がある。腫瘍の増大を予測するまたは感音難聴の進行を予測するバイオマーカーが存在せず、MRIによる画像検査と聴力検査、身体所見が治療介入の判断材料であり、外科的介入のタイミングが難しいことが挙げられる。申請者らは、Matrix metalloproteinase 14 (以下MMP14)が聴神経腫瘍における感音難聴を引き起こす原因の一つであることを報告した。本研究では、MMP14に着目し、どのように感音難聴や腫瘍増大に関わるかについて検討し、新たな治療戦略の一助とする。また、聴神経腫瘍患者のMMP14発現値の経時的変化と臨床所見について検討し、MMP14が感音難聴の進行あるいは、腫瘍増大を予測するバイオマーカーとなり得るか検討を行う。


• a

  西川 敦, 藤田 岳, 西澤祐吏, 河合俊和, 鈴木 寿

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Osaka University, Apr. 2022 - Mar. 2027, Coinvestigator

  (1)経外耳道的内視鏡下耳科手術（TEES）用内視鏡保持ロボット試作機の開発：両手手技のワークスペースを確保するため、傘型の直交ジンバル2軸と斜角45°の直動軸を有する機構、および、可動ピボットを備える直交座標系の直動3自由度機構を設計試作した（国際会議1件：CARS-ISCAS ポスター賞1位受賞、国内学会2件）。 (2) TEES用内視鏡ロボットの制御と術者の行動記録システム：前年度までに構築した器具先端位置検出画像処理システムを活用し、内視鏡把持ロボットを自律制御する基本システムを構築した。また、TEES映像内で器具・把持対象・目標物の同時セグメンテーションを可能にする新たな画像処理・行動記録システムを構築した。3名の外科医によるタスク実験を行い、両システムの有効性を評価した（国内学会2件）。 (3) 腹腔鏡手術器具の3次元位置決め：未校正のステレオカメラまたはステレオ内視鏡を用いて、ロボットが把持する腹腔鏡または手術器具を挿入孔を通して目標位置へ3次元的に高精度で位置決めさせる新しいビジュアルフィードバック制御手法を開発し、基礎評価を行った（国内学会3件）。 (4)トリアージ的意思決定の代数的再現：ブール代数を形成する多値論理上で記述された準最適化問題を試行錯誤にて解くことにより、(a)平等主義的意思決定および(b)功利主義的意思決定の複合体としての(c)トリアージ的意思決定は(b)に似ているが(a)にも僅かに傾いており、(b)に比べて治療意欲の喪失を減じる可能性があることなどを見出し、医療従事者の行動選択の本質を代数的に再現することに成功した（国際会議1件、国内学会1件、トリアージAI用C言語ライブラリおよび意思決定(a)(b)(c)を模擬した各標本のresearchmap上での公開）。 (5) 前年度の成果を2件の国内学会発表、1件の原著論文、1件の解説記事にまとめた。


• 一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索

  山田 悠祐, 松田 悠佑, 東野 哲也, 高橋 優宏, 岩崎 聡, 大石 直樹, 鬼頭 良輔, 中西 啓, 柿木 章伸, 藤田 岳, 石野 岳志, 吉田 忠雄, 菅原 一真, 實川 純人

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 国際医療福祉大学, 01 Apr. 2023 - 31 Mar. 2026


• 脂質メディエーターに着目した好酸球中耳炎の感音難聴メカニズム解明と治療法探索

  藤田 岳

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026


• Analysis of Cancer-Associated Genes using Next-Generation Sequencing in Vestibular Schwannomas

  Fujita Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2019 - 31 Mar. 2022, Principal investigator

  Vestibular schwannoma (VS) is the most common tumor of the cerebellopontine angle. The number of sporadic VS cases has increased rapidly over the last decade. Here, we completed a comprehensive genomic analysis of all the exons in the key tumor suppressor and oncogenes from small (< 15mm) sporadic VS samples. These evaluations identified NF2, SYNE1, IRS2, APC, CIC, SDHC, BRAF, NUMA1, EXT2, HRAS, BCL11B, MAGI1, RNF123, NLRP1, ASXL1, ADAMTS20, TAF1L, XPC, DDB2, and ETS1 as mutated genes and novel missense mutations in the SYNE1 transcript were identified in 20% of the samples.

  Competitive research funding


• The molecular mechanism of hearing loss in acoustic neuroma patients.

  Fujita Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), 01 Apr. 2017 - 31 Mar. 2019, Principal investigator

  The aim of this study is to elucidate the mechanism of hearing loss and tumor growth in acoustic neuromas, known as vestibular schwannoma. We performed target sequencing using Nest Generation Sequencer (NGS) . Four patients out of 10 patients (40%) showed NF2 gene mutations.

  Competitive research funding


• Novel biomaker for head and neck cancer in exosome

  Ken-ichi Nibu, Takeshi Fujita, Natsumi Uehara

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Kobe University, 01 Apr. 2015 - 31 Mar. 2017

  Technical procedures of exosome isolation and microRNA extraction from head and neck cancer cell lines were established. Based on these techniques, protocol of clinical research to identify novel biomarker for head and neck cancer was prepared and approved by Kobe University ethical committee. In this research, tissues of tumor and bloods from draining vein of tumor as well as tissues of contralateral normal organ and bloods from draining vein of contralateral normal organ are harvested. Exosomes are extracted and microRNAs are extracted from these materials. Results will be analyzed to identify novel biomarkers for head and neck cancer. Our results will contribute to early diagnosis of head and neck cancer and lead to development of gene therapy using replication-selective adenoviral vector with specific promotor for head and neck cancer.


• Clarification of pathological condition and therapeutic development of Xeroderma pigmentosum with model mice experiments

  KOJIMA Yasutaka, YAMASHITA Daisuke, FUJITA Takeshi, SHINOMIYA Hitomi, NISHIGORI Chikako

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2014 - 31 Mar. 2016

  For a treatment strategy for progressive sensorineural hearing loss in Xeroderma pigmentosum (XP), we evaluated a vulnerability of inner ears in XP complementation group A (XPA) model mice morphologically and physiologically. In auditory brainstem response, a hearing threshold of XPA model mice elevated higher than that of control group. In microscopic observation of sacrificed cochlear section, ganglion spiral cochlear cells decreased in XPA model mice. This is a first report on fragile inner ear in XPA model mice, therefore it becomes a cornerstone of inquisition of pathological condition and treatments of progressive sensorineural hearing loss in XP in the future.


• Metabolomic profiling in inner ear fluid by gas chromatograpy-mass

  HASEGAWA SHINGO, YAMASHITA Daisuke, FUJITA Takeshi, YOSHIDA Masaru

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015

  The composition and homeostasis of the inner ear fluids are important for hearing function. This study is for the first time to perform metabolome analysis of the inner ear fluid in guinea pigs cochlea using gas-chromatography/mass-spectrometry (GC/MS). Seventy-seven kinds of metabolites were detected in the inner ear fluid. Six metabolites; ascorbic acid, fructose, galactosamine, inositol, pyruvate + oxalacetic acid and meso-erythritol were significantly more abundant and nine metabolites; phosphate, valine, glycine, glycerol, ornithine, glucose, citric acid + isocitric acid, mannose and trans-4-Hydroxy-L-proline were less frequent in the inner ear fluid than in plasma. The level of ten metabolites; 3-Hydroxy-Butyrate, glycerol, fumaric acid, galactosamine, pyruvate + oxalacetic acid, phosphate, meso-erythritol, citric acid + isocitric acid, mannosea and inositol in the inner ear fluid significantly changed after loud noise exposure.


• Regulation of drug permeability of the blood-inner ear barrier by RNA interference method

  TANIMOTO Hitoshi, OTSUKI Naoki, YAMASHITA Daisuke, KATSUNUMA Sayaka, FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2012 - 31 Mar. 2015

  By RNA interference method, it is possible to suppress the transcription of protein structure of the blood-inner ear barrier, and to adjust the blood-inner ear barrier barrier mechanism. For the mouse to adjust the blood-inner ear barrier barrier mechanism, intravenous drug to the systemic administration, we want to prove that the drug has reached the inner ear. It is acoustic trauma modeling gives a huge acoustic trauma, and is administered inhibit RNA interference agent through the intravenous of which is the main protein claudin-5 transcription of the blood-inner ear barrier. Then, intravenously to be administered through the brain-derived neurotrophic factor (BDNF) as a neuroprotective agent for the purpose of inner ear disorder cell regeneration. And a control mouse morphological, we went electrophysiological comparison.

  Competitive research funding


• Mechanism of cell death and development of a new therapy against noise-induced hearing loss

  YAMASHITA Daisuke, KANZAKI Sho, FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 2011 - 2013

  We first manufactured the animal models that became hearing loss induced by intense noise. In the hearing loss animal model, we elucidated the mechanism which led to the cell death (apoptosis) of inner hair cells. Finally, based on these results, we examined the method that hearing loss was treated by various kinds of approaches, and the results that might cure hearing loss in the both sides where were in hearing function / inner ear morphology were obtained.


• Investigating the mechanism of diabetes associated hearing impairment by aging.

  FUJITA Takeshi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 2011 - 2012

  We aimed to investigate the pathophysiology of diabetes- associated hearing impairment in type1 diabetes using mice with diabetes. Chronologic changes in the ABR threshold shift were not significantly different between the diabetic and control groups. However, vessel walls in the modiolus of the cochleae were significantly thicker inthe diabetic group than the control group. Additionally, recovery from noise-induced injury was significantly impaired in diabetic mice. Our data suggest that diabetic cochleae are more susceptible than controls to loud noise exposure.