Research activity information

• The association between research funding status and clinical research papers' citation impact in Japan: A cross-sectional bibliometric study.

  Fumito Morisawa, Yuji Nishizaki, Patrick Devos, Naotake Yanagisawa, Kotone Matsuyama, Yasuhiro Homma, Rieko Ueda, Miwa Sekine, Hiroyuki Daida, Tohru Minamino, Shoji Sanada

  INTRODUCTION: Studies have not sufficiently clarified the differences in citation impact between funded and non-funded clinical research papers. Hence, this study seeks to evaluate the relation between research funding status and clinical research papers' citation impact in different research fields using multiple evaluation indices. METHODS: In this cross-sectional bibliometric study, clinical research papers published by core clinical research hospitals in Japan were compared retrospectively in terms of times cited (TC), category normalized citation impact (CNCI), citation percentile (CP), journal impact factor (JIF), the Software to Identify, Manage, and Analyze Scientific Publications (SIGAPS) category, and whether they were the funded clinical research. The association between research funding status or the SIGAPS category and CNCI ≥ 2 was analyzed using logistic regression analysis. RESULTS: 11 core clinical research hospitals published 553 clinical research papers, of which 120 were non-funded and 433 were funded (public institution-funded and industry-funded). The study found that funded clinical research papers (public institution-funded and industry-funded) had significantly higher TC, CNCI, CP, and JIF than non-funded ones [TC: 8 (3-17) vs. 14 (8-31), p < 0.001; CNCI: 0.53 (0.19-0.97) vs. 0.87 (0.45-1.85), p < 0.001; CP: 51.9 (24.48-70.42) vs. 66.7 (40.53-88.01), p < 0.001; JIF: 2.59 (1.90-3.84) vs. 2.93 (2.09-4.20) p = 0.008], while the proportion of A or B rank clinical research papers of the SIGAPS category was not significantly different between the two groups (30.0 vs. 34.9%, p = 0.318). In the logistic regression analysis, having a CNCI ≥ 2 was significantly associated with research funding (public institution-funded and industry-funded) and publication in A or B rank journals of the SIGAPS category [research funding: Estimate 2.169, 95% confidence interval (CI) 1.153-4.083, p = 0.016; SIGAPS category A/B: Estimate 6.126, 95% CI 3.889-9.651, p < 0.001]. CONCLUSION: Analysis via multiple indicators including CNCI and the SIGAPS category, which allows for a comparison of the papers' citation impact in different research fields, found a positive relation between research funding status and the citation impact of clinical research papers.

  2022, Frontiers in medicine, 9, 978174 - 978174, English, International magazine

  [Refereed]

  Scientific journal


• Performance Index for Types of Clinical Research Support Service Providers for Academic Research Organizations in Japan: A Cross-Sectional Survey.

  Keiko Ueda, Naoto Uemura, Kotone Matsuyama, Yuji Nishizaki, Nanae Tanemura, Kento Asano, Yuki Otsuka, Naotake Yanagisawa, Toshiaki Otsuka, Shinji Yasuno, Rieko Ueda, Yumiko Seo, Hironori Nakagami, Shoji Sanada

  Mar. 2021, Clinical and translational science, 14(2) (2), 745 - 755, English, International magazine

  [Refereed]

  Scientific journal


• 超高齢化・医療費膨張時代における循環器医療提供体制と医療政策のあり方 心血管系医療制度を改善するための急性心血管疾患の指標と転帰予測モデルの確立(Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System)

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, English

  [Refereed]


• Importance of quality assessment in clinical research in Japan

  Rieko Ueda, Yuji Nishizaki, Yasuhiro Homma, Shoji Sanada, Toshiaki Otsuka, Shinji Yasuno, Kotone Matsuyama, Naotake Yanagisawa, Masashi Nagao, Kazutoshi Fujibayashi, Shuko Nojiri, Yumiko Seo, Natsumi Yamada, Patrick Devos, Hiroyuki Daida

  2019, Frontiers in Pharmacology, 10

  [Refereed]

  Scientific journal


• Anti-HB-EGF Antibody-Mediated Delivery of siRNA to Atherosclerotic Lesions in Mice.

  Tsuchida S, Matsuzaki T, Yamato M, Okuda K, Fu HY, Araki R, Sanada S, Asanuma H, Asano Y, Asakura M, Hao H, Takashima S, Kitakaze M, Sakata Y, Mekada E, Minamino T

  Nov. 2018, International heart journal, 59(6) (6), 1425 - 1431

  [Refereed]


• Development of a novel one-step production system for injectable liposomes under GMP.

  Araki R, Matsuzaki T, Nakamura A, Nakatani D, Sanada S, Fu HY, Okuda K, Yamato M, Tsuchida S, Sakata Y, Minamino T

  Jul. 2018, Pharmaceutical development and technology, 23(6) (6), 602 - 607

  [Refereed]


• Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts

  Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze

  Dec. 2017, CARDIOVASCULAR DRUGS AND THERAPY, 31(5-6) (5-6), 501 - 510, English

  [Refereed]

  Scientific journal


• RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity

  Masaki Yamato, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

  Sep. 2017, INTERNATIONAL JOURNAL OF GERONTOLOGY, 11(3) (3), 191 - 196, English

  Scientific journal


• Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress

  Punniyakoti T. Veeraveedu, Shoji Sanada, Keiji Okuda, Hai Ying Fu, Takashr Matsuzaki, Ryo Araki, Masaki Yamato, Koubun Yasuda, Yasushi Sakata, Tomohiro Yoshimoto, Tetsuo Minamino

  Aug. 2017, BIOCHEMICAL PHARMACOLOGY, 138, 73 - 80, English

  [Refereed]

  Scientific journal


• Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats

  Keiji Okuda, Hai Ying Fu, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Punniyakoti V. Thanikachalam, Tatsuya Fukuta, Tomohiro Asai, Masaki Yamato, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Haruo Hanawa, Hiroyuki Hao, Naoto Oku, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

  Aug. 2016, PLOS ONE, 11(8) (8), e0160944, English

  [Refereed]

  Scientific journal


• Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy.

  Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M

  Jul. 2016, Journal of the American Heart Association, 5(7) (7), English

  [Refereed]

  Scientific journal


• Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction

  Hai Ying Fu, Shoji Sanada, Takashi Matsuzaki, Yulin Liao, Keiji Okuda, Masaki Yamato, Shota Tsuchida, Ryo Araki, Yoshihiro Asano, Hiroshi Asanuma, Masanori Asakura, Brent A. French, Yasushi Sakata, Masafumi Kitakaze, Tetsuo Minamino

  Mar. 2016, CIRCULATION RESEARCH, 118(5) (5), 798 - 809, English

  [Refereed]

  Scientific journal


• Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO.

  Asanuma H, Sanada S, Asakura M, Asano Y, Kim J, Shinozaki Y, Mori H, Minamino T, Takashima S, Kitakaze M

  Aug. 2014, Hypertension research : official journal of the Japanese Society of Hypertension, 37(8) (8), 716 - 23, English

  [Refereed]

  Scientific journal


• Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice.

  Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M

  May 2013, American journal of physiology. Heart and circulatory physiology, 304(10) (10), H1361 - 9

  [Refereed]


• Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.

  Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T

  Apr. 2013, Cardiovascular drugs and therapy, 27(2) (2), 125 - 132

  [Refereed]


• イヌ心臓において新たに合成したラジカル含有ナノ粒子は一酸化窒素を介して虚血再灌流傷害後の心保護を増大させる(Novel Synthesized Radical-containing Nanoparticles Augment Cardioprotection after Ischemia-reperfusion Injury via Nitric Oxide in Canine Hearts)

  Yoshida Akemi, Asanuma Hiroshi, Sanada Shoji, Sasaki Hideyuki, Takahama Hiroyuki, Asakura Masanori, Minamino Tetsuo, Takashima Seiji, Mochizuki Naoki, Kitakaze Masafumi

  (一社)日本循環器学会, Mar. 2013, Circulation Journal, 77(Suppl.I) (Suppl.I), 141 - 141, English


• Smoking Promotes Subclinical Atherosclerosis in Apparently Healthy Men-2-Year Ultrasonographic Follow-up -

  Shoji Sanada, Makoto Nishida, Kouki Ishii, Toshiki Moriyama, Issei Komuro, Keiko Yamauchi-Takihara

  Dec. 2012, CIRCULATION JOURNAL, 76(12) (12), 2884 - 2891, English

  [Refereed]

  Scientific journal


• H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.

  Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M

  Jun. 2012, Cardiovascular drugs and therapy, 26(3) (3), 217 - 226

  [Refereed]


• Repetitive transient phosphodiesterase-3 inhibition eliminates non-ischemic cardiac remodeling and failure

  Shoji Sanada, Hiroshi Asanuma, Tetsuo Minamino, Osamu Tsukamoto, Kenichiro Okada, Masafumi Kitakaze, Issei Komuro

  Bentham Science Publishers B.V., 2012, Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 12(2) (2), 130 - 136, English

  [Refereed]

  Scientific journal


• Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model.

  Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K

  Jan. 2012, Journal of cardiology, 59(1) (1), 91 - 96

  [Refereed]


• Costarring statins with ARBs: Going to be a smash hit?

  Shoji Sanada, Issei Komuro

  2011, Circulation Journal, 75(3) (3), 540 - 541, English

  [Refereed]

  Scientific journal


• A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.

  Takahama H, Asanuma H, Sanada S, Fujita M, Sasaki H, Wakeno M, Kim J, Asakura M, Takashima S, Minamino T, Komamura K, Sugimachi M, Kitakaze M

  Nov. 2010, Basic research in cardiology, 105(6) (6), 787 - 794

  [Refereed]


• Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)

  Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Satoru Yamazaki, Atsushi Nakano, Osamu Tsukamoto, Osamu Seguchi, Mitsutoshi Asai, Masanori Asakura, Hiroshi Asanuma, Shoji Sanada, Tetsuo Minamino, Issei Komuro, Masafumi Kitakaze, Seiji Takashima

  Oct. 2010, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(41) (41), 31337 - 31347, English

  [Refereed]

  Scientific journal


• Ablation of C/EBP homologous protein attenuates ER-mediated apoptosis and cardiac dysfunction induced by pressure overload.

  Fu HY, Okada Ki, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T

  Aug. 2010, Circulation, English

  [Refereed]

  Scientific journal


• X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes

  Tamaki Sawada, Tetsuo Minamino, Hai Ying Fu, Mitsutoshi Asai, Keiji Okuda, Tadashi Isomura, Satoru Yamazaki, Yoshihiro Asano, Ken-ichiro Okada, Osamu Tsukamoto, Shoji Sanada, Hiroshi Asanuma, Masanori Asakura, Seiji Takashima, Masafumi Kitakaze, Issei Komuro

  Jun. 2010, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 48(6) (6), 1280 - 1289, English

  [Refereed]

  Scientific journal


• Identification of genes related to heart failure using global gene expression profiling of human failing myocardium

  Kyung-Duk Min, Masanori Asakura, Yulin Liao, Kenji Nakamaru, Hidetoshi Okazaki, Tomoko Takahashi, Kazunori Fujimoto, Shin Ito, Ayako Takahashi, Hiroshi Asanuma, Satoru Yamazaki, Tetsuo Minamino, Shoji Sanada, Osamu Seguchi, Atsushi Nakano, Yosuke Ando, Toshiaki Otsuka, Hidehiko Furukawa, Tadashi Isomura, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

  Feb. 2010, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(1) (1), 55 - 60, English

  [Refereed]

  Scientific journal


• Interleukin-33 Prevents Apoptosis and Improves Survival After Experimental Myocardial Infarction Through ST2 Signaling

  Kenjiro Seki, Shoji Sanada, Anastacia Y. Kudinova, Matthew L. Steinhauser, Vandna Handa, Joseph Gannon, Richard T. Lee

  Nov. 2009, CIRCULATION-HEART FAILURE, 2(6) (6), 684 - U211, English

  [Refereed]

  Scientific journal


• Metformin Prevents Progression of Heart Failure in Dogs Role of AMP-Activated Protein Kinase

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masakatsu Wakeno, Shin Ito, Akiko Ogai, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Masaru Sugimachi, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze

  May 2009, CIRCULATION, 119(19) (19), 2568 - U74, English

  [Refereed]

  Scientific journal


• Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction Results From a Comparative Study With Signal-Averaged Electrocardiogram, Heart Rate Variability, and QT Dispersion

  Shunsuke Tamaki, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yasumasa Tsukamoto, Masaharu Masuda, Keiji Okuda, Yusuke Iwasaki, Taku Yasui, Masatsugu Hori, Masatake Fukunami

  Feb. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(5) (5), 426 - 435, English

  [Refereed]

  Scientific journal


• Sodium bicarbonate improves long-term clinical outcomes compared with sodium chloride in patients with chronic kidney disease undergoing an emergent coronary procedure

  Masaharu Masuda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Yuusuke Iwasaki, Taku Yasui, Masatake Fukunami

  Oct. 2008, CIRCULATION JOURNAL, 72(10) (10), 1610 - 1614, English

  [Refereed]

  Scientific journal


• Activation of ecto-5'-nucleotidase in the blood and hearts of patients with chronic heart failure.

  Fujita M, Asakura M, Sanada S, Funaya H, Tsukamoto O, Komamura K, Asanuma H, Taketani S, Isomura T, Nakamaru K, Furukawa H, Sawa Y, Hori M, Kitakaze M

  Jun. 2008, Journal of cardiac failure, 14(5) (5), 426 - 430

  [Refereed]


• Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.

  Sanada S, Asanuma H, Koretsune Y, Watanabe K, Nanto S, Awata N, Hoki N, Fukunami M, Kitakaze M, Hori M

  Oct. 2007, Hypertension research : official journal of the Japanese Society of Hypertension, 30(10) (10), 913 - 919

  [Refereed]


• IL-33 and ST2 comprise a critical biomechanically induced and card ioprotective signaling system

  Shoji Sanada, Daihiko Hakuno, Luke J. Higgins, Eric R. Schreiter, Andrew N. J. McKenzie, Richard T. Lee

  Jun. 2007, JOURNAL OF CLINICAL INVESTIGATION, 117(6) (6), 1538 - 1549, English

  [Refereed]

  Scientific journal


• S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.

  Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M

  2007, J Mol Cell Cardiol, 2007, 924 - 930, English

  [Refereed]

  Scientific journal


• The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.

  Tsukamoto O, Minamino T, Sanada S, Okada K, Hirata A, Fujita M, Shintani Y, Yulin L, Asano Y, Takashima S, Yamasaki S, Tomoike H, Hori M, Kitakaze M

  Apr. 2006, Cardiovasc Drugs Ther., English

  [Refereed]

  Scientific journal


• Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.

  Asanuma H, Minamino T, Ogai A, Kim J, Asakura M, Komamura K, Sanada S, Fujita M, Hirata A, Wakeno M, Tsukamoto O, Shinozaki Y, Myoishi M, Takashima S, Tomoike H, Kitakaze M

  Apr. 2006, J Mol Cell Cardiol., English

  [Refereed]

  Scientific journal


• Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts.

  Fujita M, Minamino T, Asanuma H, Sanada S, Hirata A, Wakeno M, Myoishi M, Okuda H, Ogai A, Okada K, Tsukamoto O, Koyama H, Hori M, Kitakaze M

  Jul. 2005, Hypertension (Dallas, Tex. : 1979), 46(1) (1), 113 - 117

  [Refereed]


• Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

  Y Li, T Minamino, O Tsukamoto, T Yujiri, Y Shintani, K Okada, Y Nagamachi, M Fujita, A Hirata, S Sanada, H Asanuma, S Takashima, M Hori, GL Johnson, M Kitakaze

  Apr. 2005, CIRCULATION, 111(13) (13), 1672 - 1678, English

  [Refereed]

  Scientific journal


• Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts.

  Hirata A, Minamino T, Asanuma H, Sanada S, Fujita M, Tsukamoto O, Wakeno M, Myoishi M, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Tomoike H, Hori M, Kitakaze M

  Jan. 2005, Cardiovascular drugs and therapy, 19(1) (1), 33 - 40

  [Refereed]


• A calcium channel blocker amlodipine increases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts.

  Asanuma H, Minamino T, Sanada S, Ogita H, Kim J, Fujita M, Hirata A, Tsukamoto O, Ogai A, Node K, Hori M, Tomoike H, Kitakaze M

  2005, J Mol Cell Cardiol, 39, 605 - 614, English

  [Refereed]

  Scientific journal


• Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts.

  Shintani Y, Node K, Asanuma H, Sanada S, Takashima S, Asano Y, Liao Y, Fujita M, Hirata A, Shinozaki Y, Fukushima T, Nagamachi Y, Okuda H, Kim J, Tomoike H, Hori M, Kitakaze M

  Dec. 2004, Journal of molecular and cellular cardiology, 37(6) (6), 1213 - 1218

  [Refereed]


• Ischemic preconditioning: emerging evidence, controversy, and translational trials

  S Sanada, M Kitakaze

  Nov. 2004, INTERNATIONAL JOURNAL OF CARDIOLOGY, 97(2) (2), 263 - 276, English

  [Refereed]


• Optimal windows of statin use for immediate infarct limitation - 5 '-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase

  S Sanada, H Asanuma, T Minamino, K Node, S Takashima, H Okuda, Y Shinozaki, A Ogai, M Fujita, A Hirata, JY Kim, Y Asano, H Mori, H Tomoike, S Kitamura, M Hori, M Kitakaze

  Oct. 2004, CIRCULATION, 110(15) (15), 2143 - 2149, English

  [Refereed]

  Scientific journal


• Are cardiotonic agents cardioprotective?

  Shoji Sanada, Masafumi Kitakaze

  Sep. 2004, Respiration and Circulation, 52(9) (9), 891 - 896, Japanese

  Scientific journal


• Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice

  YL Liao, M Asakura, S Takashima, A Ogai, Y Asano, Y Shintani, T Minamino, H Asanuma, S Sanada, J Kim, S Kitamura, H Tomoike, M Hori, M Kitakaze

  Aug. 2004, CIRCULATION, 110(6) (6), 692 - 699, English

  [Refereed]

  Scientific journal


• Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C

  S Sanada, H Asanuma, O Tsukamoto, T Minamino, K Node, S Takashima, T Fukushima, A Ogai, Y Shinozaki, M Fujita, A Hirata, H Okuda, H Shimokawa, H Tomoike, M Hori, M Kitakaze

  Jul. 2004, CIRCULATION, 110(1) (1), 51 - 57, English

  [Refereed]

  Scientific journal


• b-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts

  H Asanuma, T Minamino, S Sanada, S Takashima, H Ogita, A Ogai, M Asakura, YL Liao, Y Asano, Y Shintani, J Kim, Y Shinozaki, H Mori, K Node, S Kitamura, H Tomoike, M Hori, M Kitakaze

  Jun. 2004, CIRCULATION, 109(22) (22), 2773 - 2779, English

  [Refereed]

  Scientific journal


• Lamr1 functional retroposon causes right ventricular dysplasia in mice

  Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, H Asanuma, S Sanada, J Kim, A Ogai, T Fukushima, Y Oikawa, Y Okazaki, Y Kaneda, M Sato, J Miyazaki, S Kitamura, H Tomoike, M Kitakaze, M Hori

  Feb. 2004, NATURE GENETICS, 36(2) (2), 123 - 130, English

  [Refereed]

  Scientific journal


• Raloxifene prevents cardiac hypertrophy and dysfunction in pressure-overloaded mice.

  Ogita H, Node K, Liao Y, Ishikura F, Beppu S, Asanuma H, Sanada S, Takashima S, Minamino T, Hori M, Kitakaze M

  2004, Hypertension, 43, 237 - 242, English

  [Refereed]

  Scientific journal


• Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.

  Asanuma H, Sanada S, Ogai A, Minamino T, Takashima S, Asakura M, Ogita H, Shinozaki Y, Mori H, Node K, Tomoike H, Hori M, Kitakaze M

  2004, J Cardiovasc Pharmacol, 43, 574 - 579, English

  [Refereed]

  Scientific journal


• Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: Role of phosphatidylinositol 3-kinase/Akt pathway.

  Ogita H, Node K, Asanuma H, Sanada S, Kim J, Takashima S, Minamino T, Hori M, Kitakaze M

  2004, J Cardiovasc Pharmacol, 43, 237 - 242, English

  [Refereed]

  Scientific journal


• Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts.

  Fujita M, Minamino T, Sanada S, Asanuma H, Hirata A, Ogita H, Okada K, Tsukamoto O, Takashima S, Tomoike H, Node K, Hori M, Kitakaze M

  2004, J Mol Cell Cardiol, 37, 1219 - 1223, English

  [Refereed]

  Scientific journal


• Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic no inhibition in rats.

  Sanada S, Node K, Minamino T, Takashima S, Ogai A, Asanuma H, Ogita H, Liao Y, Asakura M, Kim J, Hori M, Kitakaze M

  2003, Hypertension, 41, 963 - 967, English

  [Refereed]

  Scientific journal


• Celiprolol increases coronary blood flow and reduces severity of myocardial ischemia via nitric oxide release.

  Asanuma H, Node K, Minamino T, Sanada S, Takashima S, Ueda Y, Sakata Y, Asakura M, Kim J, Ogita H, Tada M, Hori M, Kitakaze M

  2003, J Cardiovasc Pharmacol, 41, 499 - 505, English

  [Refereed]

  Scientific journal


• Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts.

  Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M, Kitakaze M

  2003, J Cardiovasc Pharmacol, 41, 964 - 969, English

  [Refereed]

  Scientific journal


• Canine DNA array as a potential tool for combining physiology and molecular biology.

  Asakura M, Takashima S, Asano Y, Honma T, Asanuma H, Sanada S, Shintani Y, Liao Y, Kim J, Ogita H, Node K, Minamino T, Yorikane R, Agai A, Kitamura S, Tomoike H, Hori M, Kitakaze M

  2003, Circ J, 67, 788 - 792, English

  [Refereed]

  Scientific journal


• Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model.

  Liao Y, Takashima S, Asano Y, Asakura M, Ogai A, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogita H, Tomoike H, Hori M, Kitakaze M

  2003, Circ Res, 93, 759 - 766, English

  [Refereed]

  Scientific journal


• Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart

  Hisakazu Ogita, Koichi Node, Hiroshi Asanuma, Shoji Sanada, Yulin Liao, Seiji Takashima, Masanori Asakura, Hidezo Mori, Yoshiro Shinozaki, Masatsugu Hori, Masafumi Kitakaze

  Sep. 2002, Journal of the American College of Cardiology, 40(5) (5), 998 - 1005, English

  [Refereed]

  Scientific journal


• Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: Role of 70-kDa S6 kinase and extracellular signal-regulated kinase

  Shoji Sanada, Koichi Node, Hiroshi Asanuma, Hisakazu Ogita, Seiji Takashima, Tetsuo Minamino, Masanori Asakura, Yulin Liao, Akiko Ogai, Jiyoong Kim, Masatsugu Hori, Masafumi Kitakaze

  Sep. 2002, Journal of the American College of Cardiology, 40(5) (5), 991 - 997, English

  [Refereed]

  Scientific journal


• Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis - Role of 70-kDa S6 kinase and extracellular signal-regulated kinase

  S Sanada, K Node, H Asanuma, H Ogita, S Takashima, T Minamino, M Asakura, WL Liao, A Ogai, J Kim, M Hori, M Kitakaze

  Sep. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40(5) (5), 991 - 997, English

  [Refereed]

  Scientific journal


• Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium: Role of bradykinin

  Masafumi Kitakaze, Hiroshi Asanuma, Hiroharu Funaya, Koichi Node, Seiji Takashima, Shoji Sanada, Masanori Asakura, Hisakazu Ogita, Jiyoong Kim, Masatsugu Hori

  Jul. 2002, Journal of the American College of Cardiology, 40(1) (1), 162 - 166, English

  [Refereed]

  Scientific journal


• Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

  S Takashima, M Kitakaze, M Asakura, H Asanuma, S Sanada, F Tashiro, H Niwa, J Miyazaki, S Hirota, Y Kitamura, T Kitsukawa, H Fujisawa, M Klagsbrun, M Hori

  Mar. 2002, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(6) (6), 3657 - 3662, English

  [Refereed]

  Scientific journal


• Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

  M Asakura, M Kitakaze, S Takashima, Y Liao, F Ishikura, T Yoshinaka, H Ohmoto, K Node, K Yoshino, H Ishiguro, H Asanuma, S Sanada, Y Matsumura, H Takeda, S Beppu, M Tada, M Hori, S Higashiyama

  Jan. 2002, NATURE MEDICINE, 8(1) (1), 35 - 40, English

  [Refereed]

  Scientific journal


• [Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart].

  Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Asakura M, Kitakaze M, Hori M

  Jan. 2002, Journal of cardiology, 39(1) (1), 55 - 56

  [Refereed]


• Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: Necropsy validation.

  Liao Y, Ishikura F, Beppu S, Asakura M, Takashima S, Asanuma H, Sanada S, Kim J, Ogita H, Kuzuya T, Node K, Kitakaze M, Hori M

  2002, Am J Physiol Heart Circ Physiol, 282, H1703-H1708, English

  [Refereed]

  Scientific journal


• Adenosine-induced cardiac gene expression of ischemic murine hearts revealed by cDNA array hybridization.

  Asakura M, Kitakaze M, Sakata Y, Asanuma H, Sanada S, Kim J, Ogita H, Liao Y, Node K, Takashima S, Tada M, Hori M

  2002, Circ J, 66, 93 - 96, English

  [Refereed]

  Scientific journal


• Cardioprotective Effect Afforded by Transient Exposure to Phosphodiesterase-III Inhibitors. -The Role of Protein Kinase A and P38 Mitogen-activated Protein Kinase-

  Sanada S, Kitakaze M, Asanuma H, Papst PJ, Node K, Liao Y, Shinozaki Y, Ogita H, Takashima S, Sakata Y, Asakura M, Kuzuya T, Terada N, Mori H, Hori M

  Oct. 2001, Circulation, 104, 705 - 710, English

  [Refereed]

  Scientific journal


• Nifedipine limits infarct size via NO-dependent mechanisms in dogs.

  H Asanuma, M Kitakaze, H Funaya, S Takashima, T Minamino, K Node, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, T Kuzuya, M Tada, M Hori

  OBJECTIVES: Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that nifedipine increases cardiac NO levels in the ischemic canine hearts, suggesting that nifedipine may also have protective effects against ischemia and reperfusion injury, because the enhancement of NO production limits infarct size. We tested whether nifedipine limits infarct size via NO-dependent mechanisms. METHODS: In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed at 6 hours of reperfusion. Nifedipine of 3 or 6 microg/kg/min was infused into the bypass tube between 10 min prior to the onset of ischemia and 60 min of reperfusion. RESULTS: Neither systemic blood pressure nor heart rate changed during infusion of nifedipine. Infarct size was reduced by the administration of nifedipine (3 or 6 microg/kg/min) compared with the untreated condition (25.6+/-2.6 and 19.1+/-3.5 vs. 43.4+/-5.6%, respectively), which was completely blunted by L-NAME (45.0+/-3.6 and 45.4+/-4.2 vs. 47.9+/-3.9% in the nifedipine (3 or 6 microg/kg/min) with L-NAME groups vs. the L-NAME group). Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by nifedipine. The limitation of infarct size and the attenuation in myeloperoxidase actiivity were completely blunted by L-NAME. There were no significant differences in collateral blood flow at 45 min of ischemia between each group. CONCLUSIONS: We conclude that the Ca channel blocker, nifedipine, limits infarct size via NO-dependent mechanisms.

  Sep. 2001, Basic research in cardiology, 96(5) (5), 497 - 505, English, International magazine

  Scientific journal


• Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium

  M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Shinozaki, H Mori, H Sato, T Kuzuya, M Hori

  Sep. 2001, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 33(9) (9), 1727 - 1737, English

  [Refereed]

  Scientific journal


• Role of Phasic Dynamism of P38 Mitogen-activated Protein Kinase Activation in the Ischemic Preconditioning on the Canine Heart.

  Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Kuzuya T, Mori H, Terada N, Yoshida Ki, Hori M

  Jul. 2001, Circ Res., 88, 175 - 180, English

  [Refereed]

  Scientific journal


• cDNA array hybridization reveals cardiac gene expression in acute ischemic murine hearts.

  Kitakaze M, Asakura M, Sakata Y, Asanuma H, Sanada S, Kuzuya T, Miyazaki J, Takashima S, Hori M

  Mar. 2001, Cardiovasc Drugs Ther, 15: 125-130, English

  Scientific journal


• Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts.

  H Asanuma, M Kitakaze, K Node, S Takashima, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, M Tada, T Kuzuya, M Hori

  Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion injury via bradykinin- and NO-dependent mechanisms. We examined this possibility. In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and was occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed by TTC staining at 6 hours of reperfusion. When benidipine doses of 50, 100, and 200 ng/kg/min were infused via the bypass tube between 10 min prior to the onset of ischemia and after 60 min of reperfusion, systemic blood pressure did not change significantly. Infarct size decreased with the administration of benidipine (50, 100, and 200 ng/kg/min) when compared to the untreated condition (24.8+/-2.5, 17.3+/-3.1, and 16.5+/-2.0 vs. 43.4+/-5.6%, respectively) associated with the increased release of NO and bradykinin in the coronary venous blood upon reperfusion. Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by benidipine. The limitation of infarct size and the increase in myeloperoxidase activity were completely blunted by either L-NAME or HOE140. There were no significant differences in collateral blood flow assessed by the microsphere method after 45 min of ischemia for any of the groups. Thus, we conclude that the Ca channel blocker, benidipine, limits infarct size via bradykinin- and NO-dependent mechanisms.

  2001, Cardiovascular drugs and therapy, 15(3) (3), 225 - 31, English, International magazine

  Scientific journal


• Role of mitochondrial and sarcolemmal KATP channels in ischemic preconditioning of the canine heart.

  Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M

  2001, Am J Physiol Heart Circ Physiol, 280, H256-H263, English

  [Refereed]

  Scientific journal


• Differential subcellular actions of ACE inhibitors and AT1 receptor antagonists on cardiac remodeling induced by chronic inhibition of no synthesis in rats.

  Sanada S, Kitakaze M, Node K, Takashima S, Ogai A, Asanuma H, Sakata Y, Asakura M, Ogita H, Liao Y, Fukushima T, Yamada J, Minamino T, Kuzuya T, Hori M

  2001, Hypertension, 38, 404 - 411, English

  [Refereed]

  Scientific journal


• Synergic role of opening of the sarcolemmal and mitochondrial ATP-sensitive K^+ channels in ischemic preconditioning.

  KITAKAZE Masafumi, SANADA Shoji, ASANUMA Hiroshi, NODE Koichi, MINAMINO Tetsuo, TAKASHIMA Seiji, CHUJO Mitsuaki, SHINOZAKI Yoshiro, MORI Hidezo, KUZUYA Tsunehiko, HORI Masatsugu

  先行する短時間心筋虚血 (ischemic preconditioning) は, 長時間虚血により生じる心筋壊死サイズを縮小する.本研究では, 麻酔開胸イヌを用いそのメカニズムを検討した.その結果, 1) ischemic preconditioningによる心筋梗塞サイズ縮小効果には, アデノシン産生酵素活性化が関与する, 2) protein kinase C活性化に加えてATP感受性K⁺チャネル開口がアデノシン産生酵素活性化に関与する, 3) 細胞膜・ミトコンドリアに存在するATP感受性K⁺チヤネルが独立して相加的にischemic preconditioningに関与する, ことが明らかになった.以上の結果より, ischemic preconditioningによる心筋保護作用にはアデノシンーアデノシン産生酵素・protein kinase C・ATP感受性K⁺チャネル開口が連関している可能性が示された.

  The Japanese Society of Electrocardiology, Mar. 2000, Japanese Journal of Electrocardiology, 20(2) (2), 103 - 111, Japanese


• Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs.

  Kitakaze M, Asanuma H, Takashima S, Minamino T, Ueda Y, Sakata Y, Asakura M, Sanada S, Kuzuya T, Hori M

  Feb. 2000, Circulation, English

  [Refereed]

  Scientific journal


• Dispersion of signal-averaged P wave duration on precordial body surface in patients with paroxysmal atrial fibrillation

  T. Yamada, M. Fukunami, T. Shimonagata, K. Kumagai, S. Sanada, H. Ogita, Y. Asano, M. Hori, N. Hoki

  Feb. 1999, European Heart Journal, 20(3) (3), 211 - 220, English

  [Refereed]

  Scientific journal


• Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide.

  Minamino T, Kitakaze M, Sanada S, Asanuama H, Kurotobi T, Koretsune Y, Fukunami M, Kuzuya T, Hoki N, Hori M

  Oct. 1998, Circulation, 33(2) (2), 103 - 104, English

  [Refereed]

  Scientific journal


• Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation - Role of nitric oxide

  T Minamino, M Kitakaze, S Sanada, H Asanuama, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori

  Oct. 1998, CIRCULATION, 98(17) (17), 1721 - 1727, English

  [Refereed]

  Scientific journal


• Prediction of the effectiveness of long-term beta blocker treatment for dilated cardiomyopathy by signal averaged electrocardiography.

  Yamada T, Fukunami M, Shimonagata T, Kumagai K, Kim J, Sanada S, Ogita H, Hori M, Hoki N

  1998, Heart, 79, 256 - 261, English

  [Refereed]

  Scientific journal


• Prediction of transition to chronic atrial fibrillation in patients with paroxysmal atrial fibrillation by signal-averaged electrocardiography: a prospective study.

  Abe Y, Fukunami M, Yamada T, Ohmori M, Shimonagata T, Kumagai K, Kim J, Sanada S, Hori M, Hoki N

  Nov. 1997, Circulation, 96, 2612 - 2616, English

  [Refereed]

  Scientific journal


• Detection of patients with sick sinus syndrome by use of low amplitude potentials early in filtered P wave

  Takahisa Yamada, Masatake Fukunami, Kazuaki Kumagai, Yasushi Abe, Jiyoong Kim, Shoji Sanada, Masatsugu Hori, Takenobu Kamada, Noritake Hoki

  Elsevier USA, 1996, Journal of the American College of Cardiology, 28(3) (3), 738 - 744, English

  [Refereed]

  Scientific journal

• Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, Mar. 2019, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, English


• わが国の循環器医療提供体制の課題と展望 望ましい体制を構築するための急性冠症候群および急性大動脈症候群の医療体制を示す指標を創造する試み(Efforts on Creating Index of Medical Service System for Acute Coronary Syndrome and Acute Aortic Syndrome to Construct Desirable System)

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 中村 文明, 斎藤 能彦, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, Mar. 2018, 日本循環器学会学術集会抄録集, 82回, SY11 - 4, English


• フェーズ1試験において健康男性に心電図上観察された食事性二相性T波変化に関する報告

  姚 香景, 中谷 大作, 真田 昌爾, 砂 真一郎, 川村 陽子, 玉井 克人, 山本 洋一, 竹原 徹郎, 名井 陽, 西田 幸二

  (一社)日本臨床薬理学会, Oct. 2016, 臨床薬理, 47(Suppl.) (Suppl.), S301 - S301, Japanese


• Cardiac-specific Overexpression of ER Chaperone GRP78 Attenuates Doxorubicin-Induced Cardiac Dysfunction

  Haiying Fu, Takashi Matsuzaki, Shoji Sanada, Tetsuo Minamino

  Oct. 2014, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S185 - S185, English

  Summary international conference


• Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-Based Population

  Takuya Hasegawa, Masanori Asakura, Hideaki Kanzaki, Jiyoong Kim, Hiroshi Asanuma, Shoji Sanada, Akira Funada, Makoto Amaki, Hiroyuki Takahama, Takahiro Ohara, Toshihisa Anzai, Masafumi Kitakaze

  Nov. 2012, CIRCULATION, 126(21) (21), English

  Summary international conference


• Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts

  A. Yoshida, S. Sanada, H. Asanuma, H. Sasaki, H. Takahama, M. Asakura, T. Yoshitomi, Y. Nagasaki, M. Kitakaze

  Aug. 2012, EUROPEAN HEART JOURNAL, 33, 957 - 957, English

  Summary international conference


• The less embraces the greater in detecting multiple coronary artery disease

  Shoji Sanada, Masafumi Kitakaze, Issei Komuro

  2012, Circulation Journal, 76(2) (2), 299 - 300, English

  Book review


• Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

  Shoji Sanada, Issei Komuro, Masafumi Kitakaze

  Nov. 2011, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 301(5) (5), H1723 - H1741, English

  Book review


• Inhaled hydrogen gas therapy reduced infarct size via mitochondrial KATP channels and mitochondrial permeability transition pore in a dog model of myocardial ischemia reperfusion injury

  A. Yoshida, H. Asanuma, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, N. Mochizuki, M. Kitakaze

  Aug. 2011, EUROPEAN HEART JOURNAL, 32, 577 - 577, English

  Summary international conference


• Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model

  Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

  Nov. 2010, CIRCULATION, 122(21) (21), English

  Summary international conference


• Combined Renin-Angiotensin System-Inhibition Therapy - What Really Accounts for the Additive Benefits?

  Shoji Sanada, Masafumi Kitakaze

  Nov. 2010, CIRCULATION JOURNAL, 74(11) (11), 2288 - 2289, English

  Others


• Inhalation of hydrogen gas reduced infarct size following ischemia and reperfusion via mitochondrial KATP channels in canine hearts

  A. Yoshida, H. Asanuma, H. Sasaki, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, M. Kitakaze

  Sep. 2010, EUROPEAN HEART JOURNAL, 31, 42 - 42, English

  Summary international conference


• Cardiac I-123 Metaiodobenzylguanidine Imaging Provides Additional Prognostic Power to Seattle Heart Failure Model in Patients With Chronic Heart Failure: A 10-year Follow-up Comparative Study

  Yuki Kuramoto, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Takeshi Okada, Shunsuke Tamaki, Wayne C. Levy, Masatake Fukunami

  Nov. 2009, CIRCULATION, 120(18) (18), S861 - S861, English

  Summary international conference


• The Optimal Antithrombotic Therapy for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention With Stenting

  Yusuke Iwasaki, Masatake Fukunami, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Taku Yasui, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki

  Mar. 2009, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A429 - A429, English

  Summary international conference


• METFORMIN THERAPY IS ASSOCIATED WITH IMPROVED CARDIAC FUNCTION AND IMPROVED INSULIN RESISTANCE IN DOGS

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Shin Ito, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Kyongduk Min, Kazuo Komamura, Masaru Sugumachi, Naoki Mochizuki, Masafumi Kitakaze

  2009, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 316 - 316, English

  Summary international conference


• Management of Hyperphosphatemia Is an Important Novel Therapeutic Target In Chronic Heart Failure

  Hiroshi Asanuma, Masanori Asakura, Jiyoong Kim, Hiroyuki Takahama, Hideyuk Sasaki, Shoji Sanada, Takahiro Ohara, Kyondoku Min, Shin Ito, Masashi Fujita, Yoshihiro Asano, Seiji Takashima, Tetsuo Minamino, Kazuo Komamura, Masafumi Kitakaze

  Oct. 2008, CIRCULATION, 118(18) (18), S433 - S434, English

  Summary international conference


• The Effects of Anglotensin II Receptor Blockade on Atrial Late Potential in Paroxysmal Atrial Fibrillation Patients with Hypertension

  Takashi Morita, Takahisa Yamada, Yuji Okuyama, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasul, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki, Masatake Fukunami

  Oct. 2008, CIRCULATION, 118(18) (18), S829 - S829, English

  Summary international conference


• Usefulness of Cardiac I-123 Metalodobenzylguanidine Imaging for Predictor of Sudden Cardiac Death in Chronic Heart Failure Patients with Mild to Moderate Systolic Dysfunction : A 10-Year Follow up Study

  Hiromichi Ueda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Takeshi Okada, Masato Kawasaki, Masataka Fukunami

  Oct. 2008, CIRCULATION, 118(18) (18), S1067 - S1067, English

  Summary international conference


• Activation of Myocardial AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs; Involvement of eNOS Activation

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Shin Ito, Kyungduk Min, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze

  Oct. 2008, CIRCULATION, 118(18) (18), S286 - S287, English

  Summary international conference


• Clinical Significance of Serial Studies of Cardiac I-123 Metaiodobenzylguanidine Imaging for the Prediction of Sudden Death in Patients with Chronic Heart Failure

  Takeshi Okada, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Masatake Fukunami

  Oct. 2008, CIRCULATION, 118(18) (18), S1066 - S1067, English

  Summary international conference


• Cardiac I-123 metaiodobenzylguanidine imaging predicts the risk of cardiac death in patients with chronic heart failure, irrespective of renal dysfunction. A prospective 10-year follow up study

  Yusuke Iwasaki, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Yoshio Furukawa, Shoji Sanada, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Taku Yasui, Masataka Fukunami

  Mar. 2008, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A160 - A160, English

  Summary international conference


• The combination of cardiac I-123 metaiodobenzylguanidine and subclinical hypothyroidism identifies patients with chronic heart failure at higher risk for poor outcome

  Taku Yesui, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Yusuke Iwasaki, Masatake Fukunami

  Mar. 2008, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A172 - A172, English

  Summary international conference


• Activation of A(1) adenosine receptors inhibits the adrenal aldosterone production and attenuates severity of heart failure

  Osamu Tsukamoto, Tetsuo Minamino, Shoji Sanada, Hidetoshi Okazaki, Ichiro Hisatome, Seiji Takashima, Yasunori Shintani, Yoshihiro Asano, Masafumi Kitakaze

  Oct. 2006, CIRCULATION, 114(18) (18), 440 - 440, English

  Summary international conference


• Nongenomic effects of alclosterone on ischemic hearts via PKC-dependent pathways

  M Fujita, T Minamino, S Takashima, H Asanuma, S Sanada, A Hirata, M Wakeno, M Myoishi, H Okuda, M Hori, M Kitakaze, A Ogai

  Oct. 2005, CIRCULATION, 112(17) (17), U76 - U76, English

  Summary international conference


• Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs

  A Hirata, T Minamino, H Asanuma, S Sanada, M Fujita, M Wakeno, Y Nagamachi, S Takashima, Y Asano, M Hori, M Kitakaze

  Oct. 2005, CIRCULATION, 112(17) (17), U255 - U255, English

  Summary international conference


• Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Hirata Akio, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Fujita Masashi, Wakeno Masakatsu, Myoishi Masafumi, Tsukamoto Osamu, Okada ken-ichiro, Komamura Kazuo, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 493 - 494, English


• Nongenomic Deleterious Effects of Aldosterone on Ischemic Hearts via PKC-Dependent Pathway in Dogs(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Fujita Masashi, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Hirata Akio, Wakeno Masakatsu, Myoishi Masafumi, Okada Ken-ichiro, Tsukamoto Osamu, Okuda Hiroko, Tomoike Hitonobu, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 01 Mar. 2005, Circulation journal : official journal of the Japanese Circulation Society, 69, 468 - 468, English


• OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))

  Tsukamoto Osamu, Minamino Tetsuo, Takashima Seiji, Okada Kenichiro, Hirata Akio, Fujita Masashi, Shintani Yasunori, Asano Yoshihiro, Sanada Shoji, Asanuma Hiroshi, Ri Ken, Liao Yulin, Takashima Seiji, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 01 Mar. 2004, Circulation journal : official journal of the Japanese Circulation Society, 68, 337 - 337, English


• Active LBP/p40-Retropseudogene interacting with heterochromatin protein 1 causes right ventricular dysplasia

  Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, S Sanada, T Fukushma, M Hori, M Kitakaze

  Oct. 2003, CIRCULATION, 108(17) (17), 32 - 32, English

  Summary international conference


• Protein kinase A-induced Rho-kinase inhibition as a novel mediator of ischemic preconditioning independent of protein kinase C

  S Sanada, H Asanuma, O Tsukamoto, S Takashima, Y Liao, T Fukushima, Y Okuda, Y Shinozaki, K Node

  Oct. 2003, CIRCULATION, 108(17) (17), 186 - 186, English

  Summary international conference


• Selective estrogen receptor modulator raloxifene inhibits the cardiac hypertrophy and dysfunction due to aortic banding in mice

  H Ogita, K Node, H Asanuma, S Sanada, S Takashima, T Minamino, M Asakura, J Kim, Y Liao, Y Asano, Y Shintani, K Okada, M Fujita, A Hirata, O Tsukamoto, M Hori, M Kitakaze

  Mar. 2003, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41(6) (6), 228A - 228A, English

  Summary international conference


• Preischemic Protein Kinase-A Activation Evokes Ischemic Preconditioning through Rho-Kinase Inhibition Independent of Protein Kinase-C : A Novel Mechanism

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Kim Jiyoong, Minamino Tetsuo, Takashima Seiji, Fukushima Tomi, Shinozaki Yoshiro, Asakura Masanori, Ogai Akiko, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 87 - 87, English


• Preischemic Protein Kinase-A Activation Triggers Cardioprotection of Ischemic Preconditioning via the Inhibition of Rho-Kinase

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Shinozaki Yoshiro, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 01 Mar. 2003, Circulation journal : official journal of the Japanese Circulation Society, 67, 303 - 303, English


• Opening of ATP-Sensitive Potassium Channel Attenuates Cardiac Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis

  SANADA Shoji, NODE Koichi, ASANUMA Hiroshi, OGITA Hisakazu, TAKASHIMA Seiji, MINAMINO Tetsuo, ASAKURA Masanori, HORI Masatsugu, KITAKAZE Masafumi

  15 Jan. 2003, Journal of cardiology, 41(1) (1), 43 - 44, Japanese


• Pravastatin selectively increases coronary blood flow during coronary hypoperfusion through the activation of nitric oxide synthesis in dogs

  S Sanada, H Asanuma, H Ogita, Y Shintani, YL Liao, T Minamino

  Nov. 2002, CIRCULATION, 106(19) (19), 13 - 13, English

  Summary international conference


• イヌDNAマイクロアレイを用いた慢性心不全の循環生理・分子生物学的病態解析

  浅沼 博司, 朝倉 正紀, 野出 孝一, 高島 成二, 南野 哲男, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史

  (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 150 - 150, Japanese


• Ca2+感受性K+チャネル開口薬(NS1619)の心筋虚血・再灌流障害抑制効果

  新谷 泰範, 野出 孝一, 浅沼 博司, 真田 昌爾, 扇田 久和, 高島 成二, 朝倉 正紀, 南野 哲男, 朝野 仁裕, 堀 正二, 北風 政史

  (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 224 - 224, Japanese


• 虚血心におけるアンジオテンシン変換酵素阻害薬とアンジオテンシンII受容体拮抗薬の併用効果 冠血流増加,心筋収縮・代謝不全改善作用

  浅沼 博司, 野出 孝一, 高島 成二, 南野 哲男, 朝倉 正紀, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史

  (一社)日本心臓病学会, Aug. 2002, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 383 - 383, Japanese


• 虚血プレコンディショニング現象におけるPKA活性化の意義 一過性p38MARK活性化の役割

  真田 昌爾, 北風 政史, 野出 孝一, 浅沼 博司, 扇田 久和, 新谷 泰範, 高島 成二, 南野 哲男, 朝倉 正紀, 朝野 仁裕

  日本適応医学会, Jun. 2002, 適応医学, 6(1) (1), 25 - 25, Japanese


• A Role of Transient Preischemic Activation of Protein Kinase-A in Ischemic Preconditioning in Vivo : Involvement of p38 Mitogen-activated Protein Kinase

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Takashima Seiji, Asakura Masanori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 697 - 697, English


• Rho-kinase Inhibitiors Administered After the Onset of Reperfusion Limit Infarct Size : A Novel Strategy for Adjunctive Therapies Against Myocardial Infarction

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Takashima Seiji, Asakura Masanori, Shintani Yasunori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 699 - 699, English


• The Long-acting Calcium Channel Blockers Attenuate Cardiac Hypertrophy Induced by Chronic NO Inhibition : The Investigation of the Potential Subcellular Mechanisms

  Sanada Shoji, Node Koichi, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Asanuma Hiroshi, Ogita Hisakazu, Asano Yoshihiro, Shintani Yasunori, Hori Masatsugu, Kitakaze Masafumi

  Japanese Circulation Society, 31 Mar. 2002, Circulation journal : official journal of the Japanese Circulation Society, 66, 442 - 442, English


• Amlodipine increases coronary blood flow and reduces the severity of myocardial ischemia in canine hearts: Roles of NO and adenosine

  R Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 324A - 324A, English

  Summary international conference


• Selective serotonin 5HT(2A) receptor inhibition attenuates myocardial ischemia through the increase in nitric oxide production: The alternative role of 5HT(1B) receptor

  S Sanada, M Kitakaze, K Node, H Asanuma, H Ogita, S Takashima, M Asakura, T Minamino, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 292A - 292A, English

  Summary international conference


• A new development of high fidelity canine DNA microarray: Application for the assessment of gene expressions of reversibly or irreversibly injured ischemic myocardium

  M Asakura, M Kitakaze, S Sanada, H Asanuma, S Takashima, T Minamino, K Node, H Ogita, Y Asano, Y Shintani, L Yulin, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 299A - 300A, English

  Summary international conference


• ACE inhibitors and angiotensin II receptor antagonists independently but synergistically increase coronary blood flow and attenuates the severity of contractile and metabolic dysfunction in ischemic hearts

  M Kitakaze, K Node, S Takashima, T Minamino, H Asanuma, M Asakura, J Kim, S Sanada, H Ogita, Y Asano, Y Shintani, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 288A - 288A, English

  Summary international conference


• The selective estrogen receptor modulator, raloxifene, improves the severity of myocardial ischemia in canine hearts

  H Ogita, M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Asano, Y Shintani, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 442A - 443A, English

  Summary international conference


• Inhibitory effects of the novel antagonist of both GP IIb/IIIa and vitronectin receptors on the formation of coronary thromboemboli caused by an inhibition of adenosine receptors during coronary hypoperfusion in dogs

  H Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori

  Mar. 2002, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 300A - 300A, English

  Summary international conference


• The selective estrogen receptor modulator, raloxifene, reduces infarct size and ventricular arrhythmias in canine hearts

  H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, YL Liao, S Takashima, M Asakura, H Mori, Y Shinozaki, M Hori

  Oct. 2001, CIRCULATION, 104(17) (17), 150 - 150, English

  Summary international conference


• Difference in the subcellular actions of ACE inhibitors and AT1 blockers on attenuating cardiac hypertrophy induced by chronic inhibition of nitric oxide synthesis in vivo

  S Sanada, T Sata, Y Sakata, S Takashima

  Oct. 2001, CIRCULATION, 104(17) (17), 190 - 190, English

  Summary international conference


• The dihydropyridine Ca channel blocker, nifedipine, limits infarct size via bradykinin- and NO-dependent mechanisms in dogs

  M Kitakaze, Y Shinozaki, H Mori, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, English

  Summary international conference


• Ischemia-selective early increase in nitric oxide synthesis confer acute cardioprotection against myocardial infarction afforded by pravastatin

  S Sanada, M Kitakaze, H Asanuma, S Takashima, K Node, H Ogita, M Asakura, YL Liao, T Kuzuya, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, English

  Summary international conference


• Amelioration of ischemia- and reperfusion-induced myocardial injury by raloxifene: Roles of nitric oxide and the opening of calcium-activated potassium channels

  H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, S Takashima, M Asakura, YL Liao, Y Shinozaki, H Mori, T Kuzuya, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 362A - 363A, English

  Summary international conference


• A novel inhibitory effect of adenosine on cardiac hypertrophy

  M Asakura, M Kitakaze, S Takashima, S Higashiyama, Y Sakata, H Asanuma, S Sanada, H Ogita, YL Liao, K Node, T Toyofuku, T Kuzuya, M Tada, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 272A - 272A, English

  Summary international conference


• Nitric oxide attenuates angiotensin II-induced activation of p70 S6 kinase and protein synthesis in rat cardiomyocytes via cyclic GMP-dependent mechanisms

  M Kitakaze, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 294A - 295A, English

  Summary international conference


• Heparin-binding EGF-like growth factor (HB-EGF) plays a critical role in the EGFR transactivation after angiotensin II stimulation in vascular smooth muscle cells

  M Asakura, M Kitakaze, S Takashima, S Higashiyama, H Asanuma, S Sanada, Y Sakata, H Ogita, YL Liao, T Toyofuku, T Kuzuya, M Tada, M Hori

  Feb. 2001, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 270A - 270A, English

  Summary international conference


• K+チャネル開口薬ニコランジルのNo-reflow現象抑制効果及び心筋梗塞縮小効果の検討

  浅沼博司, 北風政史, 真田昌爾, 高島成二, 野出孝一, 朝倉正紀, 扇田久和, 坂田泰彦, 葛谷恒彦, 多田道彦, 堀正二

  2001, Therapeutic Research, 22, 698 - 700, Japanese

  [Invited]

  Introduction scientific journal


• アデノシンと心筋保護—プレコンディショニングとの関わり

  真田昌爾, 北風政史, 浅沼博司, 南野哲男, 野出孝一, 高島成二, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二

  2001, 日本臨床生理学会雑誌, 31, 73 - 78, Japanese

  [Invited]

  Introduction scientific journal


• ニコランジル長期投与によりNO欠乏による慢性心肥大が血圧非依存性に抑制される—KATPチャネル開口がp70S6KとERKに及ぼす影響

  真田昌爾, 北風政史, 南野哲男, 野出孝一, 浅沼博司, 坂田泰彦, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二

  2001, Therapeutic Research, 22, 708 - 711, Japanese

  [Invited]

  Introduction scientific journal


• MX68, a new derivative of methotrexate, limits infarct size via adenosine-dependent mechanisms in dogs

  H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 370A - 370A, English

  Summary international conference


• Carvedilol limits infarct size via adenosine-dependent mechanisms in dogs

  H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 350A - 350A, English

  Summary international conference


• Transient exposure of nicotine attenuates the severity of canine myocardial stunning via alpha(1)-adrenergic receptor activation and augmentation of ecto 5 '-nucleotidase activity

  S Sanada, M Kitakaze, H Asanuma, H Ogita, K Harada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 369A - 369A, English

  Summary international conference


• The effects of ischemic preconditioning on adenosine deaminase and kinase activities in the canine heart

  M Kitakaze, H Asanuma, S Sanada, S Takashima, Y Ueda, Y Sakata, M Asakura, H Ogita, T Kuzuya, M Hori

  Feb. 2000, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 401A - 401A, English

  Summary international conference


• Protein tyrosine kinase is not involved in the infarct size-limiting effect of ischemic preconditioning in canine hearts

  Masafumi Kitakaze, Koichi Node, Hiroshi Asanuma, Seiji Takashima, Yasuhiko Sakata, Masanori Asakura, Shoji Sanada, Yoshiro Shinozaki, Hidezo Mori, Tsunehiko Kuzuya, Masatsugu Hori

  2000, Circ Res, 87, 303 - 308


• 細胞膜／ミトコンドリアATP感受性K+チャネルは相加的に心筋梗塞サイズ縮小効果を発揮する—麻酔開胸犬での検討

  真田昌爾, 北風政史, 浅沼博司, 扇田久和, 葛谷恒彦, 篠崎芳郎, 盛英三, 堀正二

  2000, Therapeutic Research, 21, 785 - 788, Japanese

  [Invited]

  Introduction scientific journal


• Both sarcolemmal and mitochondrial ATP-sensitive potassium channels synergistically mimic the infarct size-limiting effect of ischemic preconditioning in the canine heart

  S Sanada, S Takashima, K Harada, Y Shinozaki, H Mori, M Kitakaze

  Nov. 1999, CIRCULATION, 100(18) (18), 717 - 717, English

  Summary international conference


• Transient exposure to nicotine mediates the infarct size-limiting effect via activation of ecto-5'-nucleotidase. Role of alpha(1)-adrenoceptor activation.

  H Asanuma, S Sanada, H Mori, Y Shinozaki, T Kuzuya

  Nov. 1999, CIRCULATION, 100(18) (18), 838 - 838, English

  Summary international conference


• Inhibition of p38 mitogen-activated protein kinase blunts the infarct size-limiting effect of ischemic preconditioning in the in vivo canine heart

  S Sanada, S Takashima, Y Sakata, M Asakura, N Terada

  Nov. 1999, CIRCULATION, 100(18) (18), 492 - 492, English

  Summary international conference


• Increased membrane and soluble P-selectin in atrial fibrillation - Response

  T Minamino, M Kitakaze, S Sanada, H Asanuma, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori

  Oct. 1999, CIRCULATION, 100(17) (17), E86 - E87, English

  Report scientific journal


• 心嚢液貯留,甲状腺機能異常を認め,血清中に高分子Immunogloblinの過剰発現をみた大動脈炎症候群の1例

  木村 泰之, 高島 成二, 真田 昌爾, 森田 孝, 辻村 英一郎, 坂田 泰史, 山本 一博, 佐藤 洋, 葛谷 恒彦, 桑原 敬介

  (一社)日本循環器学会, 20 Aug. 1999, Japanese Circulation Journal, 63(2) (2), 762 - 762, Japanese


• Role of opening of ATP-sensitive K^+ channels in cardioprotection afforded by ischemic preconditioning-investigation of cellular mechanisms.

  KITAKAZE M, SANADA S, ASANUMA H, NODE K, MINAMINO T, TAKASHIMA S, CHUJO M, MORI H, KUZUYA T, HORI M

  25 Mar. 1999, 心電図 = Electrocardiology, 19(2) (2), 161 - 169, Japanese


• Prediction of paroxysmal atrial fibrillation in patients with congestive heart failure by P wave signal-averaged EGG: A prospective study.

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Oct. 1998, CIRCULATION, 98(17) (17), 441 - 441, English

  Summary international conference


• Anatomical basis of QT dispersion in patients with dilated cardiomyopathy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano

  Oct. 1998, CIRCULATION, 98(17) (17), 441 - 441, English

  Summary international conference


• 0048 I-123MIBG心筋イメージングによる慢性心不全患者の予後評価 : 前向き研究

  扇田 久和, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese


• 0385 心不全悪化の指標としての体表面加算平均心電図P波持続時間の有用性

  朝野 仁裕, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 扇田 久和, 伯耆 徳武

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese


• 0387 失神患者におけるatrial early potentialによる洞不全症候群の検出

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese


• P071 慢性心不全患者におけるP波加算平均心電図による発作性心房細動の発症予測 : prospective study

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese


• P633 P波加算平均心電図の体表面マッピングによる発作性心房細胞発作に対するPilsicainideの再発予防効果予測

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 28 Feb. 1998, Japanese circulation journal, 62(0) (0), Japanese


• Dobutamine induced late potentials are related to the residual myocardial viability after acute myocardial infarction with reperfusion therapy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 447A - 447A, English

  Summary international conference


• Detection of patients at risk for paroxysmal atrial fibrillation improved by body surface mapping of P-wave signal-averaged ECG

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, English

  Summary international conference


• Prediction of efficacy or pilsicainide to paroxysmal atrial fibrillation by body surface mapping of the P-wave signal-averaged ECG: A prospective study

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, English

  Summary international conference


• Apoptosis of myocardial cell is associated with the abnormal signal-averaged ECG in patients with idiopathic dilated cardiomyopathy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, English

  Summary international conference


• Prediction of the effectiveness of long-term beta-blocker therapy for dilated cardiomyopathy by signal-averaged electrocardiography: A prospective study

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  Feb. 1998, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, English

  Summary international conference


• A prospective study to predict the transition from paroxysmal atrial fibrillation to chronic atrial fibrillation by signal-averaged electrocardiography

  H Ogita, M Fukunami, T Shimonagata, K Kumagai, T Yamada, J Kim, S Sanada, N Hoki

  Feb. 1997, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91218 - 91218, English

  Summary international conference


• Reproducibility and long-term change of the P wave-triggered signal-averaged ECG

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, J Kim, S Sanada, H Ogita, N Hoki

  Feb. 1997, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91213 - 91213, English

  Summary international conference


• 拡張型心筋症化した非虚血性心不全と重症心室性不整脈に対しβ遮断薬が有効であった一例

  真田昌爾, 福並正剛, 下永田剛, 熊谷和明, 山田貴久, 扇田久和, 朝野仁裕, 伯耆徳武

  1997, 診療と新薬, 34, 1267 - 1269, Japanese

  [Invited]

  Report scientific journal

• Proposal of a novel pathomechanism of glaucomatous optic neuropathy as dysregulated lactate shuttle and signal transduction and exploration of treatment

  中村 誠, 坂本 麻里, 楠原 仙太郎, 目黒 明, 盛 崇太朗, 真田 昌爾

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2027


• Exploration for Aggravating Process of Heart Failure Induced by Specific Interaction with G-protein-coupled Receptor and Toll-like Receptor

  Sanada Shoji, MINAMINO Tetsuo, HIGO Shuichiro, ASANO Yoshihiro, TSUKAMOTO Osamu

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2013 - 31 Mar. 2016

  We and others have reported that ablation of ST2 caused exaggerated cardiac remodeling in both ischemic and non-ischemic HF. We tested whether IL-33 protects myocardium against HF induced by mechanical overload. Following TAC, myocardial mRNA expressions of Th2 cytokines were diminished while those of Th1 were enhanced in IL-33KO mice than in WT mice. After 8-weeks, IL-33KO mice exhibited exacerbated LV hypertrophy, increased chamber dilation, reduced fractional shortening, aggravated fibrosis and impaired survival compared with WT littermates. Accordingly, myocardial mRNA expressions of fibrogenic (TGF-b1/Collagen3a1) as well as hypertrophic (c-Myc/BNP) molecular markers were also significantly enhanced in IL-33KO mice than those in WT mice. In conclusion, the ablation of IL-33 directly and significantly lead to exacerbate cardiac remodeling with impaired cardiac function and survival upon mechanical stress. These data reveal a potential therapeutic role for IL-33 in non-ischemic HF.


• A New Diagnostics Method for Refractory Heart Failure

  ASANO YOSHIHIRO, HIGO Shuichiro, TSUKAMOTO Osamu, MINAMINO Tetsuo, KATO Hisakazu, OGITA Hisakazu, SANADA Shoji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2012 - 31 Mar. 2015

  Higher order structures in the cell nucleus have been demonstrated to change during development and differentiation. Such structural remodeling occurred in the cell nucleus can be observed as changes in high electron density areas called chromatin by electron microscopy. Alterations in nuclear chromatin structure have been reported some relation with physiological changes. Based on our experimental findings of chromatin remodeling as an upstream of pathological gene expression in cardiomyocytes, we focused on changes in nuclear chromatin structure of cardiomyocytes in patients with dilated cardiomyopathy (DCM). Using our original quantitation methods to analyze the ultrastructure of chromatin, we conducted a retrospective observational study assessing the ability to identify the DCM patients with severe heart failure at risk for poor outcomes, and to make an accurate and an early determination of the indication for some ventricular assist devices to support the failing heart.


• Role of ER oxidoreductin-1 in cardiovascular remodeling

  MINAMINO TETSUO, HIGO Schuichiro, HAO Hiroyuki, ASANO Yoshihiro, SANADA Shoji, TSUKAMOTO Osamau

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Osaka University, 01 Apr. 2012 - 31 Mar. 2015

  Hypoxic stimuli play important roles in the development of cardiovascular diseases such as ischemic heart disease, atherosclerosis. In the present study, to clarify the role of ER oxidoreductin-1 (Ero1), a major ER oxidase, in the development of abdominal aortic aneurysm, we have tried and succeeded to create Ero1 knockout mice by ES trap method. Interestingly, we found that Ero1 expression increased in human samples from abdominal aortic aneurysm. We also found that continuous infusion of angiotensin II induced abdominal aortic aneurysm in Ero1 knockout, but not normal, mice, suggesting that Ero1 plays an important role in the development of abdominal aortic aneurysm.


• ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討

  中谷 大作, 真田 昌爾, 小室 一成

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 01 Apr. 2012 - 31 Mar. 2014

  平成25年度の研究実施計画は、ブタ左右腎動脈内に焼灼を実施し、6か月後の腎動脈および腎動脈周囲の傷害の程度を腎動脈造影および病理学的に評価を行うことである。また、腎動脈周囲の交感神経の傷害の程度を生理的に評価するために昇圧反応の有無からアデノシン（一般名：アデノシン三リン酸二ナトリウム）の至適投与量および投与方法の検討を行うことである。 これらを評価、検討するために、2頭のブタ腎動脈に対して、麻酔下に心臓用の不整脈焼灼カテーテルを用いて1頭目右腎動脈に12時方向を６W1分間、左腎動脈に12時方向を４W1分間、2頭目右腎動脈6時方向４W1分間、左腎動脈6時方向６W1分間にそれぞれ焼灼を行った。2頭とも左右腎動脈の近位部と遠位部に焼灼を行った。左右両腎動脈にアデノシンの急速動脈投与および、アデノシンの持続投与を焼灼6か月後にそれぞれ実施した。すべての手技が終了後、ブタを安楽死させ、腎動脈を摘出し、長軸方向に切開し、焼灼部位周辺部を組織固定した。6か月後、腎動脈造影上、いずれの血管においても狭窄像を認めなかった。ブタを安楽死させた直後に採取した腎動脈において、マクロ像として焼灼部位が白く瘢痕化していた（n=1）。組織標本については現在、作成中のため、今後評価予定。アデノシン10mgをゆっくりまたは急速に腎動脈内投与したところ、10秒後に5秒程度の昇圧反応が観察された。この反応は5mg、20mgの急速腎動脈内投与でも観察された。40mgを腎動脈内に急速投与すると5秒後に昇圧反応が観察されたが、その後、徐脈が出現。心臓に同薬剤が到達したために生じたと考えられた。2頭目の豚ではすべての用量においても昇圧反応は観察されなかった。両腎動脈ともアデノシン１γの持続投与により8分後より７～10mmHg程度の昇圧が観察されたが、アデノシン投与中止後も血圧は低下しなかった。


• Development of image diagnosis and treatment for fluminant myocarditis

  MINAMINO Tetsuo, SANADA Shoji, MATSUZAKI Takashi

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Osaka University, 2011 - 2011

  The prognosis of fluminant myocarditis due to autoimmune myocarditis is poor. Thus, the development of new treatment for fluminant myocarditis is medical unmet need. We found that nano-size particles were accumulated in myocarditis hearts. Then, we have developed FK506(an immunosuppressant drug) coated with nano-size liposome. In rat myocarditis model, we found that liposomal FK506 prevented the cardiac dysfunction more than FK506 did. Liposomes are promising for developing new treatments for fluminant myocarditis.