Research activity information

• Oct. 2010 日本生物工学会, 第18回生物工学論文賞, パン酵母β-グルカンのラットにおける脂質異常症予防効果

  FUKUDA ITSUKO, KODOI RIE, KUBO MAYUKO, OKAMOTO TAKASHI, FUJITA TSUYOSHI, ASHIDA HITOSHI

  Japan society


• Oct. 2008 日本栄養・食糧学会近畿支部, 日本栄養・食糧学会近畿支部若手奨励賞, 研究題目「芳香族炭化水素類によるアリール炭化水素受容体の活性化に対するカテキンの作用」

  福田 伊津子

• Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets.

  Ryoga Hashimoto, Keita Nishiyama, Fu Namai, Kasumi Suzuki, Taiga Sakuma, Itsuko Fukuda, Yuta Sugiyama, Kenji Okano, Takafumi Shanoh, Eita Toyoshi, Ryusuke Ohgi, Sudeb Saha, Sae Tsuchida, Eri Nishiyama, Takao Mukai, Mutsumi Furukawa, Tomonori Nochi, Julio Villena, Wakako Ikeda-Ohtsubo, Gou Yoshioka, Eri Nakazaki, Yoshihito Suda, Haruki Kitazawa

  BACKGROUND: The suckling period in pigs is a key phase in development for shaping the gut microbiota, which is essential for maintaining biological homeostasis in neonates. In piglets fed sow milk, the gut microbiota comprises predominantly lactobacilli, indicating a host-gut microbiota symbiosis that is influenced by sow milk components. In this study, we sought to elucidate the mechanisms underlying the establishment and maintenance of the gut microbiome in suckling piglets, with a specific focus on the metabolism of sialyl-oligosaccharides by lactobacilli. RESULTS: Based on liquid chromatography-mass spectrometry analysis, we identified 3'-sialyl-lactose (3'SL) as the major oligosaccharide in porcine milk, and microbiome profiling revealed the predominance of Ligilactobacillus salivarius during the suckling period, with a subsequent transition to Limosilactobacillus reuteri dominance post-weaning. Notably, sialic acid metabolism was established to be exclusively attributable to L. salivarius, thereby highlighting the pivotal role of 3'SL in determining species-specific bacterial segregation. L. salivarius was found to metabolize 3'SL when co-cultured with Bacteroides thetaiotaomicron, resulting in a shift in the predominant short-chain fatty acid produced, from lactate to acetate. This metabolic shift, in turn, inhibits the growth of enterotoxigenic Escherichia coli. Furthermore, the comparison of the gut microbiota between suckling piglets and those fed a low-3'SL formula revealed distinct diversity profiles. We accordingly speculate that an absence of sialyl-oligosaccharides in the formula-fed piglets may have restricted the growth of sialic acid-utilizing bacteria such as L. salivarius, thereby leading to a higher abundance of Enterobacteriaceae. CONCLUSIONS: Our findings reveal the influence of sialyl-oligosaccharides in promoting microbial diversity and gut homeostasis, thereby highlighting the importance of sialic acid as a key factor in shaping milk-driven microbial colonization during the early stages of piglet development. Video Abstract.

  May 2025, Microbiome, 13(1) (1), 135 - 135, English, International magazine

  Scientific journal


• Single-Nucleus RNA Sequencing Reveals Muscle-Region-Specific Differences in Fibro-Adipogenic Progenitors Driving Intramuscular Fat Accumulation

  Shuji Ueda, Chiaki Kitamura, Yuka Tateoka, Akinori Kanai, Yutaka Suzuki, Itsuko Fukuda, Yasuhito Shirai

  Mar. 2025, Metabolites, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Metabolites and Free Fatty Acids in Japanese Black Beef During Wet Aging

  Shuji Ueda, Yuka Yoshida, Yuka Tateoka, Biniam Kebede, Masakazu Shinohara, Hiroki Nakanishi, Itsuko Fukuda, Yasuhito Shirai

  Feb. 2025, Metabolites, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Additive effect of mixtures of multiple strains combining the effects of single strains on human gut microbiota in vitro

  Yuji TSUJIKAWA, Junya YAMAMOTO, Itsuko FUKUDA, Iwao SAKANE

  BMFH Press, 2025, Bioscience of Microbiota, Food and Health, 44(1) (1), 58 - 69, English

  [Refereed]

  Scientific journal


• ウシ糞便細菌叢研究におけるサンプリング方法に関する一考察

  本多健, 村田瞭斗, 田中大輔, 福田伊津子, 大山憲二

  May 2024, 関西畜産学会報, (181) (181), 7 - 11, Japanese

  [Refereed]

  Scientific journal


• Establishment of porcine fecal-derived ex vivo microbial communities to evaluate the impact of livestock feed on gut microbiome

  Yuji TSUJIKAWA, Keita NISHIYAMA, Fu NAMAI, Yoshiya IMAMURA, Taiga SAKUMA, Sudeb SAHA, Masahiko SUZUKI, Mitsuki SAKURAI, Ryo IWATA, Kengo MATSUO, Hironori TAKAMORI, Yoshihito SUDA, Binghui ZHOU, Itsuko FUKUDA, Julio VILLENA, Iwao SAKANE, Ro OSAWA, Haruki KITAZAWA

  IF = 3.1

  BMFH Press, Apr. 2024, Bioscience of Microbiota, Food and Health, 43(2) (2), 100 - 109, English, Domestic magazine

  [Refereed]

  Scientific journal


• Evaluating functionalities of food components by a model simulating human intestinal microbiota constructed at Kobe University.

  Ro Osawa, Itsuko Fukuda, Yasuhito Shirai

  In this era of pandemics, reducing the risk of lifestyle-related diseases (LRD) by functional foods is of paramount importance. The conventional process of functional food development almost invariably involves in vitro, animal, and human intervention trials, but differences in intestinal environments between humans and experimental animals make it difficult to develop functional foods that are truly effective in humans. Thus, it is necessary to construct a model that simulates the human intestinal environment to evaluate the functionality of any food component before subjecting it to a human intervention trial. In this review, we provide an overview of a model simulating human intestinal microbiota constructed at Kobe University and its use as a tool to identify food components that contribute to the prevention and treatment of LRD.

  Mar. 2024, Current opinion in biotechnology, 87, 103103 - 103103, English, International magazine

  [Refereed]

  Scientific journal


• New Implications of Metabolites and Free Fatty Acids in Quality Control of Crossbred Wagyu Beef during Wet Aging Cold Storage.

  Shuji Ueda, Yuka Yoshida, Biniam Kebede, Chiaki Kitamura, Ryo Sasaki, Masakazu Shinohara, Itsuko Fukuda, Yasuhito Shirai

  Efficient cold-chain delivery is essential for maintaining a sustainable global food supply. This study used metabolomic analysis to examine meat quality changes during the "wet aging" of crossbred Wagyu beef during cold storage. The longissimus thoracic (Loin) and adductor muscles (Round) of hybrid Wagyu beef, a cross between the Japanese Black and Holstein-Friesian breeds, were packaged in vacuum film and refrigerated for up to 40 days. Sensory evaluation indicated an increase in the umami and kokumi taste owing to wet aging. Comprehensive analysis using gas chromatography-mass spectrometry identified metabolite changes during wet aging. In the Loin, 94 metabolites increased, and 24 decreased; in the Round, 91 increased and 18 decreased. Metabolites contributing to the umami taste of the meat showed different profiles during wet aging. Glutamic acid increased in a cold storage-dependent manner, whereas creatinine and inosinic acid degraded rapidly even during cold storage. In terms of lipids, wet aging led to an increase in free fatty acids. In particular, linoleic acid, a polyunsaturated fatty acid, increased significantly among the free fatty acids. These results provide new insight into the effects of wet aging on Wagyu-type beef, emphasizing the role of free amino acids, organic acids, and free fatty acids generated during cold storage.

  Jan. 2024, Metabolites, 14(2) (2), English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Isolation and identification of hyaluronan-degrading bacteria from Japanese fecal microbiota.

  Hazuki Akazawa, Itsuko Fukuda, Haruna Kaneda, Shoichi Yoda, Mamoru Kimura, Ryohei Nomoto, Shuji Ueda, Yasuhito Shirai, Ro Osawa

  Hyaluronan (HA) is a high-molecular-weight glycosaminoglycan and widely distributed in all connective tissues and organs with diverse biological functions. HA has been increasingly used as dietary supplements targeted to joint and skin health for humans. We here first report isolation of bacteria from human feces that are capable of degrading HA to lower molecular weight HA oligosaccharides (oligo-HAs). The bacteria were successfully isolated via a selective enrichment method, in which the serially diluted feces of healthy Japanese donors were individually incubated in an enrichment medium containing HA, followed by the isolation of candidate strains from streaked HA-containing agar plates and selection of HA-degrading strains by measuring HA using an ELISA. Subsequent genomic and biochemical assays identified the strains as Bacteroides finegoldii, B. caccae, B. thetaiotaomicron, and Fusobacterium mortiferum. Furthermore, our HPLC analysis revealed that the strains degraded HA to oligo-HAs of various lengths. Subsequent quantitative PCR assay targeting the HA degrading bacteria showed that their distribution in the Japanese donors varied. The evidence suggests that dietary HA is degraded by the human gut microbiota with individual variation to oligo-HAs components, which are more absorbable than HA, thereby exerting its beneficial effects.

  2023, PloS one, 18(5) (5), e0284517, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Application of Mass Spectrometry for Determining the Geographic Production Area of Wagyu Beef

  Shuji Ueda, Yasuharu Takashima, Yunosuke Gotou, Ryo Sasaki, Rio Nakabayashi, Takeshi Suzuki, Shinji Sasazaki, Ituko Fukuda, Biniam Kebede, Yuki Kadowaki, Maiko Tamura, Hiroki Nakanishi, Yasuhito Shirai

  Japanese Black cattle (Japanese Wagyu) beef is attracting attention for its aroma and marbling, and its handling is increasing worldwide. Here, we focused on the origin discrimination of Wagyu beef and analyzed the nutritional components of Japanese Wagyu (produced in multiple prefectures of Japan), Hybrid Wagyu (a cross between Angus and Wagyu cattle born in Australia and transported to Japan), and Australian Wagyu beef using mass spectrometry (MS). Triple-quadrupole liquid chromatography–MS was used to clarify the molecular species of lipids in Wagyu beef. Fourteen classes of lipids were separated, and 128 different triacylglycerides (TGs) were detected. A simple comparative analysis of these TGs using high-performance liquid chromatography revealed significantly higher levels of triolein (C18:1/C18:1/C18:1; abbreviated OOO) and C18:1/C18:1/C16:1 (OOPo) in Japanese Wagyu. Wagyu elements beef were comprehensively analyzed using inductively coupled plasma (ICP)–MS and ICP–optical emission spectrometry. We found significant differences in the rubidium, cesium, and lithium levels of Japanese and Australian Wagyu beef. On comparing metabolites using gas chromatography–MS, we identified significant differences in the levels of amino acids and other components of the Japanese and Australian Wagyu beef. These results suggest the possibility of determining the origin of Wagyu cattle breeds using MS and genetic discrimination.

  MDPI AG, Aug. 2022, Metabolites, 12(9) (9), 777 - 777

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Pre- and Post-Harvest Conditions Affect Polyphenol Content in Strawberry (Fragaria × ananassa)

  Ryohei Koyama, Misaki Ishibashi, Itsuko Fukuda, Akitoshi Okino, Ro Osawa, Yuichi Uno

  The strawberry fruit contains abundant polyphenols, such as anthocyanins, flavan-3-ol, and ellagitannin. Polyphenol enrichment improves the quality of strawberries and leads to a better understanding of the polyphenol induction process. We measured the total polyphenol content of strawberry fruits under different growth conditions, developmental stages, and treatment conditions during pre-harvest and post-harvest periods. High fruit polyphenol content was observed in cold treatment, which was selected for further analysis and optimization. A transcriptome analysis of cold-treated fruits suggested that the candidate components of polyphenols may exist in the phenylpropanoid pathway. Coverage with a porous film bag excluded the effects of drought stress and produced polyphenol-rich strawberry fruits without affecting quality or quantity. The degree of stress was assessed using known stress indicators. A rapid accumulation of abscisic acid was followed by an increase in superoxide dismutase and DPPH (2,2-Diphenyl-1-picrylhydrazyl) activity, suggesting that the strawberry fruits responded to cold stress immediately, reaching the climax at around 6 days, a trend consistent with that of polyphenol content. These findings enhance our understanding of the mechanism of post-harvest polyphenol accumulation and the value of strawberries as a functional food.

  MDPI AG, 2022, Plants, 11(17) (17), 17 (13 pages) - 2220, English, International magazine

  [Refereed][Invited]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comparison of Fecal Microbiota of Experimental MiceKept at Different University Laboratories in Japan

  松井沙樹, 福田伊津子, 大澤朗

  Oct. 2021, 腸内細菌学雑誌, 35(4) (4), 231 - 239, Japanese

  [Refereed]

  Scientific journal


• Isolation and identification of milk oligosaccharide-degrading bacteria from the intestinal contents of suckling rats.

  Hazuki Akazawa, Yuji Tsujikawa, Itsuko Fukuda, Yoshihiro Suzuki, Moonhak Choi, Takane Katayama, Takao Mukai, Ro Osawa

  We report the isolation of bacteria capable of degrading milk oligosaccharides from suckling infant rats. The bacteria were successfully isolated via a selective enrichment method, in which the serially diluted intestinal contents of infant rats were individually incubated in an enrichment medium containing 3'-sialyllactose (3'-SL), followed by the isolation of candidate strains from streaked agar plates and selection of 3'-SL-degrading strains using thin-layer chromatography. Subsequent genomic and phenotypic analyses identified all strains as Enterococcus gallinarum. The strains were capable of degrading both 3'-SL and 6'-SL, which was not observed with the type strain of E. gallinarum used as a reference. Furthermore, a time-course study combining high-performance anion-exchange chromatography with pulsed amperometric detection revealed that the representative strain AH4 degraded 3'-SL completely to yield an equimolar amount of lactose and an approximately one-fourth equimolar amount of sialic acid after 24 hr of anaerobic incubation. These findings point to a possibility that the enterococci degrade rat milk oligosaccharides to "cross-feed" their degradants to other members of concomitant bacteria in the gut of the infant rat.

  2021, Bioscience of microbiota, food and health, 40(1) (1), 27 - 32, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Milk oligosaccharide-mediated cross-feeding between Enterococcus gallinarum and lactobacilli in the gut microbiota of infant rats.

  Saki Matsui, Hazuki Akazawa, Yuji Tsujikawa, Itsuko Fukuda, Yoshihiro Suzuki, Yuji Yamamoto, Takao Mukai, Yasuhito Shirai, Ro Osawa

  We investigated bacteria that have a nutritional symbiotic relationship with respect to milk oligosaccharides in gut microbiota of suckling rats, with specific reference to sialyllactose (SL) degrading Enterococcus gallinarum. Our next generation sequencing analysis of the colonic contents of 12-day-old suckling rats revealed that almost half of the bacteria in the microbiota belonged to the Lactobacillaceae family. Major Lactobacillus species in the contents were identified as L. johnsonii, L. murinus, and L. reuteri. We then monitored changes in numbers of the above Lactobacillus species, E. gallinarum, and the bacteria belonging to the family Enterobacteriaceae (i.e., enterobacteria) in the colonic contents of infant rats at 7, 12, 21, 28, and 35 days of age by using real-time PCR assays targeting these bacterial groups. The 7-day-old infant rats had a gut microbiota in which enterobacteria were predominant. Such dominance was replaced by L. johnsonii and the concomitant E. gallinarum markedly increased in those of 12 and 21 days of ages. During this period, the number of enterobacteria declined dramatically, but that of L. reuteri surged dramatically. Our separate in vitro experiment showed that supplementation of culture media with SL promoted the growth of L. johnsonii and E. gallinarum, with marked production of lactic acid. These findings revealed possible milk oligosaccharide-mediated cross-feeding between E. gallinarum and L. johnsonii, with the former degrading SL to release lactose to be utilized by the latter.

  2021, Bioscience of microbiota, food and health, 40(4) (4), 204 - 211, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Extracellular Vesicles Produced by Bifidobacterium longum Export Mucin-Binding Proteins.

  Keita Nishiyama, Takashi Takaki, Makoto Sugiyama, Itsuko Fukuda, Maho Aiso, Takao Mukai, Toshitaka Odamaki, Jin-Zhong Xiao, Ro Osawa, Nobuhiko Okada

  Extracellular proteins are important factors in host-microbe interactions; however, the specific factors that enable bifidobacterial adhesion and survival in the gastrointestinal (GI) tract are not fully characterized. Here, we discovered that Bifidobacterium longum NCC2705 cultured in bacterium-free supernatants of human fecal fermentation broth released a myriad of particles into the extracellular environment. The aim of this study was to characterize the physiological properties of these extracellular particles. The particles, approximately 50 to 80 nm in diameter, had high protein and double-stranded DNA contents, suggesting that they were extracellular vesicles (EVs). A proteomic analysis showed that the EVs primarily consisted of cytoplasmic proteins with crucial functions in essential cellular processes. We identified several mucin-binding proteins by performing a biomolecular interaction analysis of phosphoketolase, GroEL, elongation factor Tu (EF-Tu), phosphoglycerate kinase, transaldolase (Tal), and heat shock protein 20 (Hsp20). The recombinant GroEL and Tal proteins showed high binding affinities to mucin. Furthermore, the immobilization of these proteins on microbeads affected the permanence of the microbeads in the murine GI tract. These results suggest that bifidobacterial exposure conditions that mimic the intestine stimulate B. longum EV production. The resulting EVs exported several cytoplasmic proteins that may have promoted B. longum adhesion. This study improved our understanding of the Bifidobacterium colonization strategy in the intestinal microbiome.IMPORTANCE Bifidobacterium is a natural inhabitant of the human gastrointestinal (GI) tract. Morphological observations revealed that extracellular appendages of bifidobacteria in complex microbial communities are important for understanding its adaptations to the GI tract environment. We identified dynamic extracellular vesicle (EV) production by Bifidobacterium longum in bacterium-free fecal fermentation broth that was strongly suggestive of differing bifidobacterial extracellular appendages in the GI tract. In addition, export of the adhesive moonlighting proteins mediated by EVs may promote bifidobacterial colonization. This study provides new insight into the roles of EVs in bifidobacterial colonization processes as these bacteria adapt to the GI environment.

  Sep. 2020, Applied and environmental microbiology, 86(19) (19), English, International magazine

  [Refereed]

  Scientific journal


• Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis

  Ryohei Shinohara, Kengo Sasaki, Jun Inoue, Namiko Hoshi, Itsuko Fukuda, Daisuke Sasaki, Akihiko Kondo, Ro Osawa

  Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbiota of Japanese patients with UC and healthy volunteers (HVs). But showed higher levels than buk. Moreover, patients with UC showed significantly decreased levels of but associated with Roseburia sp./Eubacterium rectale compared with HVs. But, which is associated with Faecalibacterium sp., was maintained in patients with UC, with an unchanged relative abundance of Faecalibacterium sp. microorganisms in patients with UC compared with HVs.

  Oct. 2019, Bioscience of Microbiota, Food and Health, 38(4) (4), 159 - 163, English, Domestic magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Construction of a model culture system of human colonic microbiota to detect decreased Lachnospiraceae abundance and butyrogenesis in the feces of ulcerative colitis patients

  SASAKI KENGO, INOUE JUN, SASAKI DAISUKE, HOSHI NAMIKO, SHIRAI TOMOKAZU, FUKUDA ITSUKO, AZUMA TAKESHI, KONDO AKIHIKO, OSAWA RO

  Compositional alteration of the gut microbiota is associated with ulcerative colitis (UC). Here, a model culture system is established for the in vitro human colonic microbiota of UC, which will be helpful for determining medical interventions. 16S ribosomal RNA sequencing confirms that UC models are successfully developed from fecal inoculum and retain the bacterial species biodiversity of UC feces. The UC models closely reproduce the microbial components and successfully preserve distinct clusters from the healthy subjects (HS), as observed in the feces. The relative abundance of bacteria belonging to the family Lachnospiraceae significantly decreases in the UC models compared to that in HS, as observed in the feces. The system detects significantly lower butyrogenesis in the UC models than that in HS, correlating with the decreased abundance of Lachnospiraceae. Interestingly, the relative abundance of Lachnospiraceae does not correlate with disease activity (defined as partial Mayo score), suggesting that Lachnospiraceae persists in UC patients at a decreased level, irrespective of the alteration in disease activity. Moreover, the system shows that administration of Clostridium butyricum MIYAIRI restores butyrogenesis in the UC model. Hence, the model detects deregulation in the intestinal environment in UC patients and may be useful for simulating the effect of probiotics.

  2019, Biotechnology Journal, 14(5) (5), e1800555, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure

  Daisuke Sasaki, Kengo Sasaki, Naoko Ikuta, Takahiro Yasuda, Itsuko Fukuda, Akihiko Kondo, Ro Osawa

  Nature Publishing Group, Dec. 2018, Scientific Reports, 8(1) (1), Article number: 435, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Next-generation sequencing-based miRNA expression analysis in Parp1-deficient embryonic stem cell-derived exosomes.

  Tadashige Nozaki, Yuka Sasaki, Itsuko Fukuda, Mayu Isumi, Keitaro Nakamoto, Takae Onodera, Mitsuko Masutani

  Poly (ADP-ribose) polymerase family, member 1 (Parp1) has pleiotropic and disparate functions in multiple cellular signaling pathways through post-translational protein modification. It contributes to the regulation of various cellular processes, including DNA damage repair, cell death, and cell differentiation, genetically or epigenetically. Meanwhile, the functions of Parp1 in intercellular signaling remain to be established. To examine the functions of Parp1 in intercellular signaling, we examined microRNA (miRNA) regulation in exosomes derived from Parp1-deficient (Parp1-/-) embryonic stem (ES) cells. The percentages of miRNAs among total RNAs, including small RNAs such as miRNAs, snRNAs, snoRNAs, tRNAs, exonic RNAs, and intronic RNAs, in Parp1+/+ and Parp1-/- ES cell-derived exosomes were 8.2% and 3.5%, respectively. Overall, 329 distinct miRNAs exhibited ≥2-fold changes (118 upregulated; 211 downregulated). The upregulated miRNAs targeted 810 candidate genes, and the downregulated miRNAs targeted 716 candidate genes. Pathway analyses revealed that the upregulated miRNAs were significantly associated with five pathways including MAPK signaling cascades (p < 0.05), indicating that the target genes in these pathways were suppressed in Parp1-/- ES cells. In quantitative analyses of miRNA expression, miR365-3p, let-7a-5p, miR196b-5p, miR203-3p, miR98-5p, and miR146a-5p were increased by ≥ 2-fold in Parp1-/- ES cell-derived exosomes. Gene ontology enrichment analyses revealed that the upregulated miRNAs were significantly annotated for growth and stress-related cell signaling and cell communication (p < 0.05). Parp1 deficiency in ES cells led to inhibition of cell-cell communication, possibly by intercellular signal transduction, suggesting that Parp1 functions extracellularly by regulating exosomal miRNAs.

  May 2018, Biochemical and biophysical research communications, 499(3) (3), 410 - 415, English, International magazine

  Scientific journal


• Taurine does not affect the composition, diversity, or metabolism of human colonic microbiota simulated in a single-batch fermentation system.

  Kengo Sasaki, Daisuke Sasaki, Naoko Okai, Kosei Tanaka, Ryohei Nomoto, Itsuko Fukuda, Ken-Ichi Yoshida, Akihiko Kondo, Ro Osawa

  Accumulating evidence suggests that dietary taurine (2-aminoethanesulfonic acid) exerts beneficial anti-inflammatory effects in the large intestine. In this study, we investigated the possible impact of taurine on human colonic microbiota using our single-batch fermentation system (Kobe University Human Intestinal Microbiota Model; KUHIMM). Fecal samples from eight humans were individually cultivated with and without taurine in the KUHIMM. The results showed that taurine remained largely undegraded after 30 h of culturing in the absence of oxygen, although some 83% of the taurine was degraded after 30 h of culturing under aerobic conditions. Diversity in bacterial species in the cultures was analyzed by 16S rRNA gene sequencing, revealing that taurine caused no significant change in the diversity of the microbiota; both operational taxonomic unit and Shannon-Wiener index of the cultures were comparable to those of the respective source fecal samples. In addition, principal coordinate analysis indicated that taurine did not alter the composition of bacterial species, since the 16S rRNA gene profile of bacterial species in the original fecal sample was maintained in each of the cultures with and without taurine. Furthermore, metabolomic analysis revealed that taurine did not affect the composition of short-chain fatty acids produced in the cultures. These results, under these controlled but artificial conditions, suggested that the beneficial anti-inflammatory effects of dietary taurine in the large intestine are independent of the intestinal microbiota. We infer that dietary taurine may act directly in the large intestine to exert anti-inflammatory effects.

  2017, PloS one, 12(7) (7), e0180991, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• A Single-Batch Fermentation System to Simulate Human Colonic Microbiota for High-Throughput Evaluation of Prebiotics

  Risa Takagi, Kengo Sasaki, Daisuke Sasaki, Itsuko Fukuda, Kosei Tanaka, Ken-ichi Yoshida, Akihiko Kondo, Ro Osawa

  Aug. 2016, PLOS ONE, 11(8) (8), e0160533, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers

  Itsuko Fukuda, Shin Nishiumi, Rie Mukai, Ken-ichi Yoshida, Hitoshi Ashida

  May 2015, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 66(3) (3), 300 - 307, English

  [Refereed]

  Scientific journal


• Catechins in tea suppress the expression and activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers

  FUKUDA Itsuko, NISHIUMI Shin, MUKAI Rie, YOSHIDA Ken-ichi, ASHIDA Hitoshi

  2015, International Journal of Food Sciences and Nutrition, 66, 300 - 307, English

  [Refereed]

  Scientific journal


• Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect

  Itsuko Fukuda, Hitoshi Ashida

  Elsevier Inc., Nov. 2013, Polyphenols in Human Health and Disease, 2, 1127 - 1135, English

  [Refereed]

  In book


• Inhibitory effect of cardamonin on transformation of aryl hydrocarbon receptor

  Chao He, Tianshun Zhang, Norio Yamamoto, Itsuko Fukuda, Hitoshi Ashida

  2013, Organohalogen Compounds, 75, 620 - 624, English

  [Refereed]

  International conference proceedings


• New Structure Descriptor in the Structure-Activity Relationship Study on the Suppression of Aryl Hydrocarbon Receptor Transformation by Anthraquinones

  Masaya Kawase, Tadashi Saito, Teruo Yasunaga, Tatsuya Takagi, Itsuko Fukuda, Hitoshi Ashida

  Mar. 2012, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 18(2) (2), 173 - 176, English

  [Refereed]

  Scientific journal


• Induction of the multidrug-resistant Mdr1b mediated by aryl hydrocarbon receptor in mouse hepatoma Hepa-1c1c7 cells

  NOMURA Ayano, KINEHARA Masaki, FUKUDA Itsuko, ASHIDA Hitoshi

  2012, Organohalogen Compounds, 74, 1005 - 1008, English

  Scientific journal


• Application of a southwestern-chemistry based ELISA to evaluation of dioxins in the farm products

  FUKUDA Itsuko, ASHIDA Hitoshi

  2012, Organohalogen Compounds, 74, 173 - 176, English

  Scientific journal


• Oral toxicological studies of black soybean (Glycine max) hull extract: Acute studies in rats and mice, and chronic studies in mice

  Itsuko Fukuda, Miki Tsutsui, Tadashi Yoshida, Toshiya Toda, Takanori Tsuda, Hitoshi Ashida

  Dec. 2011, FOOD AND CHEMICAL TOXICOLOGY, 49(12) (12), 3272 - 3278, English

  [Refereed]

  Scientific journal


• Cardamonin Stimulates Glucose Uptake through Translocation of Glucose Transporter-4 in L6 Myotubes

  Norio Yamamoto, Kyuichi Kawabata, Keisuke Sawada, Manabu Ueda, Itsuko Fukuda, Kengo Kawasaki, Akira Murakami, Hitoshi Ashida

  Aug. 2011, PHYTOTHERAPY RESEARCH, 25(8) (8), 1218 - 1224, English

  [Refereed]

  Scientific journal


• A Black Soybean Seed Coat Extract Prevents Obesity and Glucose Intolerance by Up-regulating Uncoupling Proteins and Down-regulating Inflammatory Cytokines in High-Fat Diet-Fed Mice

  Yuki Kanamoto, Yoko Yamashita, Fumio Nanba, Tadashi Yoshida, Takanori Tsuda, Itsuko Fukuda, Sachiko Nakamura-Tsuruta, Hitoshi Ashida

  Aug. 2011, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 59(16) (16), 8985 - 8993, English

  [Refereed]

  Scientific journal


• Metabolic fate of orally administered enzymatically synthesized glycogen in rats

  Takashi Furuyashiki, Hiroki Takata, Iwao Kojima, Takashi Kuriki, Itsuko Fukuda, Hitoshi Ashida

  Apr. 2011, FOOD & FUNCTION, 2(3-4) (3-4), 183 - 189, English

  [Refereed]

  Scientific journal


• Prenylated chalcones 4-hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells by inducing GLUT4 translocation

  Kyuichi Kawabata, Keisuke Sawada, Kazunori Ikeda, Itsuko Fukuda, Kengo Kawasaki, Norio Yamamoto, Hitoshi Ashida

  Mar. 2011, MOLECULAR NUTRITION & FOOD RESEARCH, 55(3) (3), 467 - 475, English

  [Refereed]

  Scientific journal


• Anti-obesity and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet

  Norio Yamamoto, Yuki Kanemoto, Manabu Ueda, Kengo Kawasaki, Itsuko Fukuda, Hitoshi Ashida

  Jan. 2011, FOOD & FUNCTION, 2(1) (1), 45 - 52, English

  [Refereed]

  Scientific journal


• Acute and chronic oral toxicity studies of black soybean (Glycine max) hull extract in mice and rats

  FUKUDA Itsuko, TSUTSUI Miki, YOSHIDA Tadashi, TODA Toshiya, TSUDA Takanori, ASHIDA Hitoshi

  2011, Food and Chemical Toxicology, 49, 3272 - 3278, English

  [Refereed]

  Scientific journal


• Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes.

  Ueda M, Furuyashiki T, Yamada K, Aoki Y, Sakane I, Fukuda I, Yoshida K, Ashida H

  Nov. 2010, Food & function, 1(2) (2), 167 - 173

  [Refereed]


• Tea catechins modulate the glucose transport system in 3T3-L1 adipocytes

  Manabu Ueda, Takashi Furuyashiki, Kayo Yamada, Yukiko Aoki, Iwao Sakane, Itsuko Fukuda, Ken-Ichi Yoshida, Hitoshi Ashida

  Nov. 2010, Food and Function, 1(2) (2), 167 - 173, English

  [Refereed]

  Scientific journal


• Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction

  Rie Mukai, Yasuhito Shirai, Naoaki Saito, Itsuko Fukuda, Shin Nishiumi, Ken-ichi Yoshida, Hitoshi Ashida

  Sep. 2010, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 501(1) (1), 134 - 141, English

  [Refereed]

  Scientific journal


• Sorption of pharmaceuticals to humic substances

  MORI Hisayo, OHTANI Tomoya, FUKUDA Itsuko, ASHIDA Hitoshi, FUJITAKE Nobuhide

  Jul. 2010, Proceedings of the 15th meeting of International Humic Substances Society, Puerto de la Curz, Spain, 3, 182 - 185, English

  [Refereed]

  International conference proceedings


• Aryl hydrocarbon receptor-mediated induction of the cytosolic phospholipase A(2)alpha gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma Hepa-1c1c7 cells

  Masaki Kinehara, Itsuko Fukuda, Ken-ichi Yoshida, Hitoshi Ashida

  Oct. 2009, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 108(4) (4), 277 - 281, English

  [Refereed]

  Scientific journal


• Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (-)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats

  Itsuko Fukuda, Miki Tsutsui, Iwao Sakane, Hitoshi Ashida

  May 2009, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 73(5) (5), 1206 - 1208, English

  [Refereed]

  Scientific journal


• Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

  Itsuko Fukuda, Atsushi Kaneko, Shin Nishiumi, Masaya Kawase, Rika Nishikiori, Nobuhide Fujitake, Hitoshi Ashida

  Mar. 2009, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 107(3) (3), 296 - 300, English

  [Refereed]

  Scientific journal


• Effect of β-Glucan from bread yeast on rat cecum contents and fecal excretion

  FUKUDA Itsuko, KODOI Rie, KUBO Mayuko, FUJITAKE Nobuhide, ASHIDA Hitoshi

  A deficiency of dietary fiber causes digestive tract diseases. In the present study, the effect of β-glucan purified from baker's yeast (BBG) on the rat cecum contents and fecal excretion was examined using cellulose (CE) as a negative control fiber. Rats were fed with AIN-93M-based diet containing BBG or CE at 1%, 3%, or 5%, or a nonfiber diet for 4 weeks. Cecal tissue weight was significantly increased by 5% BBG diet compared with 5% CE diet, whereas the pH of cecal content was significantly decreased. Short-chain fatty acid including acetate, propionate, and n-butyrate in the rat cecum was significantly increased by 5% BBG diet compared with 5% CE diet, indicating that increasing the content of short-chain fatty acids in the cecum decreased the pH of cecal content. In addition, the water content of feces was also significantly increased by 5% BBG diet compared with 5% CE diet. These results suggest that BBG promote cecal fermentation and retain water in the large-intestinal lumen. In conclusion, BBG prevents constipation by modulating intestinal functions and its effectiveness is greater than that of CE.

  日本生物工学会, 2009, seibutsu-kogaku kaishi, 87(4) (4), 170 - 174, Japanese

  [Refereed]

  Scientific journal


• パン酵母β-グルカンのラットにおける脂質異常症予防効果

  FUKUDA Itsuko, KODOI Rie, KUBO Mayuko, OKAMOTO Takashi, FUJITA Tsuyosi, ASHIDA Hitoshi

  2009, 生物工学会誌, 87(3) (3), 129 - 134, Japanese

  [Refereed]

  Scientific journal


• High-throughput evaluation of aryl hydrocarbon receptor-binding sites selected via chromatin immunoprecipitation-based screening in Hepa-1c1c7 cells stimulated with 2,3,7,8-tetrachlorodibenzo-p-dioxin

  Masaki Kinehara, Itsuko Fukuda, Ken-ichi Yoshida, Hitoshi Ashida

  Dec. 2008, GENES & GENETIC SYSTEMS, 83(6) (6), 455 - 468, English

  [Refereed]

  Scientific journal


• Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle

  Manabu Ueda, Shin Nishiumi, Hironobu Nagayasu, Itsuko Fukuda, Ken-ichi Yoshida, Hitoshi Ashida

  Dec. 2008, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 377(1) (1), 286 - 290, English

  [Refereed]

  Scientific journal


• Cacao Polyphenol Extract Suppresses Transformation of an Aryl Hydrocarbon Receptor in C57BL/6 Mice

  Rie Mukai, Itsuko Fukuda, Shin Nishiumi, Midori Natsume, Naomi Osakabe, Ken-ichi Yoshida, Hitoshi Ashida

  Nov. 2008, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 56(21) (21), 10399 - 10405, English

  [Refereed]

  Scientific journal


• Suppressive effects of flavonoids on activation of the aryl hydrocarbon receptor induced by dioxins

  Itsuko Fukuda, Hitoshi Ashida

  American Chemical Society, Sep. 2008, ACS Symposium Series, 993, 369 - 374, English

  [Refereed]

  International conference proceedings


• Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig

  Shin Nishiumi, Yoshiyuki Yabushita, Takashi Furuyashiki, Itsuko Fukuda, Hitoshi Ashida

  Jun. 2008, TOXICOLOGY AND APPLIED PHARMACOLOGY, 229(3) (3), 281 - 289, English

  [Refereed]

  Scientific journal


• Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor

  Shin Nishiumi, Norio Yamamoto, Rie Kodoi, Itsuko Fukuda, Ken-Ichi Yoshida, Hitoshi Ashida

  Feb. 2008, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 470(2) (2), 187 - 199, English

  [Refereed]

  Scientific journal


• Suppressive effects of propolis extract on cytochrome P4501A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

  Daisuke Kashiwada, Itsuko Fukuda, Ken-ichi Yoshida, Hitoshi Ashida

  2008, Journal of Clinical Biochemistry and Nutrition, 43(Suppl.1), 460 - 463, English

  [Refereed]

  Scientific journal


• Effect of chamomile extract on adiposity in mice fed a high-fat diet

  Tomohiro Ohno, Hironori Tomi, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida

  2008, Journal of Clinical Biochemistry and Nutrition, 43(Suppl.1), 243-246, English

  [Refereed]

  Scientific journal


• Cyanidin 3-glucoside ameliorates hyperglycemia and, insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice

  Rie Sasaki, Natsumi Nishimura, Hiromi Hoshino, Yasuka Isa, Maho Kadowaki, Takahito Ichi, Akihito Tanaka, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida, Fumihiko Horio, Takanori Tsuda

  Dec. 2007, BIOCHEMICAL PHARMACOLOGY, 74(11) (11), 1619 - 1627, English

  [Refereed]

  Scientific journal


• Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids

  Itsuko Fukuda, Rie Mukai, Masaya Kawase, Ken-ichi Yoshida, Hitoshi Ashida

  Aug. 2007, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 359(3) (3), 822 - 827, English

  [Refereed]

  Scientific journal


• TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers

  Mika Hamada, Hideo Satsu, Yayoi Natsume, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida, Makoto Shimizu

  Nov. 2006, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 54(23) (23), 8891 - 8898, English

  [Refereed]

  Scientific journal


• Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins

  S Nishiumi, Y Yabushita, Fukuda, I, R Mukai, KI Yoshida, H Ashida

  Feb. 2006, FOOD AND CHEMICAL TOXICOLOGY, 44(2) (2), 250 - 260, English

  [Refereed]

  Scientific journal


• Screening of indigenous plants from Japan for modulating effects on transformation of the aryl hydrocarbon receptor

  Shin Nishiumi, Keizo Hosokawa, Rie Mukai, Itsuko Fukuda, Atsuyuki Hishida, Osamu Iida, Ken-Ichi Yoshida, Hitoshi Ashida

  Asian Pacific Organization for Cancer Prevention, 2006, Asian Pacific Journal of Cancer Prevention, 7(2) (2), 208 - 220, English

  [Refereed]

  Scientific journal


• (+)-Catechin suppresses the inhibition of 3T3-L1 differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin

  Itsuko Fukuda, Sayaka Terashima, Hitoshi Ashida

  2006, ITE Letters on Batteries, New Technologies & Medicine, 7(3), 292-295, English

  [Refereed]

  Scientific journal


• A frequent drinking of green tea lowers the levels of endogenous oxidative stress in small intestines, erythrocytes and kidneys in rats

  SAKAKIBARA Hiroyuki, ASHIDA Hitoshi, FUKUDA Itsuko, FURUYASHIKI Takashi, SANO Takashi, NONAKA Yuji, HASHIMOTO Takashi, KANAZAWA Kazuki

  Jan. 2006, Journal of Clinical Biochemistry and Nutrition, Vol. 39, No. 1, pp. 32-39, English

  [Refereed]

  Scientific journal


• Suppressive effects of ethanolic extracts from propolis and its main botanical origin on dioxin toxicity

  YK Park, Fukuda, I, H Ashida, S Nishiumi, KI Yoshida, A Daugsch, HH Sato, GM Pastore

  Dec. 2005, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 53(26) (26), 10306 - 10309, English

  [Refereed]

  Scientific journal


• Suppressive effects of commercial beverages on TCDD-induced aryl hydrocarbon receptor transformation

  YABUSHITA Y, FUKUDA Itsuko, NISHIUMI Shin, ASHIDA Hitoshi

  Sep. 2005, ITE Letters on Batteries, New Technologies & Medicine, 6 4 372-377, English

  [Refereed]

  Scientific journal


• Black tea theaflavins suppress dioxin-induced transformation of the aryl hydrocarbon receptor

  Fukuda, I, Sakane, I, Y Yabushita, S Sawamura, K Kanazawa, H Ashida

  May 2005, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 69(5) (5), 883 - 890, English

  [Refereed]

  Scientific journal


• Anthocyans fail to suppress transformation of aryl hydrocarbon receptor induced by dioxin

  R Mukai, Fukuda, I, K Hosokawa, S Nishiumi, A Kaneko, H Ashida

  May 2005, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 69(5) (5), 896 - 903, English

  [Refereed]

  Scientific journal


• Tea has the potential to reduce the dioxin risk

  FUKUDA Itsuko, SAKANE I, NISHIUMI Shin, SHIRASUGI S, SAWAMURA S, KANAZAWA Kazuki, YOSHIDA Kenichi, ASHIDA Hitoshi

  2005, Proceedings of 2004 International Conference on O-CHA(tea) Culture and Science, 594-595, English

  International conference proceedings


• Intake of green tea increases antioxidative potency in rats

  SAKAKIBARA H, ASHIDA Hitoshi, FUKUDA Itsuko, FURUYASHIKI T, NONAKA Y, SANO T, KANAZAWA Kazuki

  2005, Proceedings of 2004 International Conference on O-CHA(tea) Culture and Science, 513-514, English

  International conference proceedings


• Pigments in green tea leaves (Camellia sinensis) suppress transformation of the aryl hydrocarbon receptor induced by dioxin

  Fukuda, I, Sakane, I, Y Yabushita, R Kodoi, S Nishiumi, T Kakuda, SI Sawamura, K Kanazawa, H Ashida

  May 2004, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 52(9) (9), 2499 - 2506, English

  [Refereed]

  Scientific journal


• Suppression of dioxin mediated aryl hydrocarbon receptor transformation by ethanolic extracts of propolis

  YK Park, Fukuda, I, H Ashida, S Nishiumi, JP Guzman, HH Sato, GA Pastore

  Apr. 2004, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(4) (4), 935 - 938, English

  Scientific journal


• A new southwestern chemistry-based ELISA for detection of aryl hydrocarbon receptor transformation: application to the screening of its receptor agonists and antagonists

  Fukuda, I, S Nishiumi, Y Yabushita, R Mukai, R Kodoi, K Hashizume, M Mizuno, Y Hatanaka, H Ashida

  Apr. 2004, JOURNAL OF IMMUNOLOGICAL METHODS, 287(1-2) (1-2), 187 - 201, English

  Scientific journal


• Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P450 1A subfamily in the mouse liver

  T Okamoto, R Kodoi, Y Nonaka, Fukuda, I, T Hashimoto, K Kanazawa, M Mizuno, H Ashida

  2004, BIOFACTORS, 21(1-4) (1-4), 407 - 409, English

  Scientific journal


• Black tea extract suppresses transformation of aryl hydrocarbon receptor induced by dioxin

  Fukuda, I, Sakane, I, Y Yabushita, S Sawamura, K Kanazawa, H Ashida

  2004, BIOFACTORS, 21(1-4) (1-4), 367 - 369, English

  [Refereed]

  Scientific journal


• Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin

  R Mukai, Fukuda, I, S Nishiumi, K Hosokawa, K Kanazawa, H Ashida

  2004, BIOFACTORS, 21(1-4) (1-4), 371 - 373, English

  [Refereed]

  Scientific journal


• Suppression of cytochrome P4501 a subfamily in mouse liver by oral intake of polysaccharides from mushrooms, Lentinus edodes and Agaricus blazei

  H Ashida, T Hashimoto, Y Nonaka, Fukuda, I, K Kanazawa, G Danno, K Minato, S Kawakami, M Mizuno

  2003, FOOD FACTORS IN HEALTH PROMOTION AND DISEASE PREVENTION, 851, 235 - 248, English

  [Refereed]

  Scientific journal


• N-acetyl-L-cysteine suppresses constitutive expression of CD11a/LFA-1 alpha protein in myeloid lineage

  K Hashizume, Y Hatanaka, Fukuda, I, T Sano, Y Yamaguchi, Y Tani, G Danno, K Suzuki, H Ashida

  Oct. 2002, LEUKEMIA RESEARCH, 26(10) (10), 939 - 944, English

  [Refereed]

  Scientific journal


• Up-regulation of CD13/aminopeptidase N induced by phorbol ester is involved in redox regulation and tumor necrosis factor alpha production in HL-60 cells

  Y Hatanaka, H Ashida, K Hashizume, Fukuda, I, T Sano, Y Yamaguchi, T Endo, Y Tani, K Suzuki, G Danno

  Aug. 2002, INFLAMMATION, 26(4) (4), 175 - 181, English

  [Refereed]

  Scientific journal


• Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice

  T Hashimoto, Y Nonaka, K Minato, S Kawakami, M Mizuno, Fukuda, I, K Kanazawa, H Ashida

  Jul. 2002, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 66(7) (7), 1610 - 1614, English

  [Refereed]

  Scientific journal


• Apoptosis in the thymus after intraperitoneal injection of rats with Trp-P-1

  Takashi Hashimoto, Takashi Furuyashiki, Takashi Sano, Kaori Kihara, Itsuko Fukuda, Wakana Ito, Pyoyun Park, Kazuki Kanazawa, Gen-Ichi Danno, Hitoshi Ashida

  2002, Environmental and Molecular Mutagenesis, 40(3) (3), 175 - 183, English

  [Refereed]

  Scientific journal


• The heterocyclic amine, 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells

  H Ashida, K Kihara, Y Nonaka, Fukuda, I, B Shiotani, T Hashimoto

  Nov. 2001, TOXICOLOGY AND APPLIED PHARMACOLOGY, 177(1) (1), 59 - 67, English

  [Refereed]

  Scientific journal


• Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin

  H Ashida, Fukuda, I, T Yamashita, K Kanazawa

  Jul. 2000, FEBS LETTERS, 476(3) (3), 213 - 217, English

  [Refereed]

  Scientific journal

• 日本人潰瘍性大腸炎患者の腸内細菌叢における2種の酪酸産生遺伝子の定量

  篠原 涼平, 佐々木 建吾, 井上 潤, 星 奈美子, 福田 伊津子, 佐々木 大介, 近藤 昭彦, 大澤 朗

  (公財)日本ビフィズス菌センター, Apr. 2019, 腸内細菌学雑誌, 33(2) (2), 105 - 105, Japanese


• 食品トレーサビリティシステム

  FUKUDA ITSUKO, OSAWA RO

  医学書院, Nov. 2015, 公衆衛生, 79(11) (11), 753 - 757, Japanese

  [Invited]

  Introduction scientific journal


• 生物工学会論文賞紹介記事「パン酵母β-グルカンのラットにおける脂質異常症予防効果 」(生物工学会誌, 87 (3),129－134, 2009掲載分)

  FUKUDA Itsuko, KODOI Rie, KUBO Mayuko, OKAMOTO Takashi, FUJITA Tsuyoshi, ASHIDA Hitoshi

  日本生物工学会, 2011, 生物工学会誌, 89(2) (2), 71 - 71, Japanese

  [Invited]

  Book review


• 明日葉カルコン4-hydroxyderricinおよびxanthoangelolの糖取り込み促進作用とその分子機序の検討

  川畑球一, 池田和法, 澤田圭介, 福田伊津子, 川崎健吾, 山本憲朗, 芦田均

  2010, 日本農芸化学会大会講演要旨集, 2010


• 3P-1159 Studies on interactions of protein-food factor by capillary electrophoresis

  Kitano Rei, Kawase Masaya, Ihara Ikko, Fukuda Itsuko, Ashida Hitoshi

  日本生物工学会, 2010, 日本生物工学会大会講演要旨集, 22, 97 - 97, Japanese


• ヨモギ抽出物によるGLUT4膜移行促進作用機構の解明

  上田学, 川崎健吾, 山本憲朗, 室崎伸二, 福田伊津子, 吉田健一, 吉田健一, 芦田均, 芦田均

  2009, 日本農芸化学会大会講演要旨集, 2009


• ショウガ科植物成分カルダモニンおよびアルピネチンの筋細胞におけるGLUT4依存的な糖取込促進作用

  山本憲朗, 川畑球一, 川崎健吾, 福田伊津子, 芦田均

  2009, 日本香辛料研究会講演要旨集, 24th


• 細胞内糖取り込みを誘導するポリフェノールの探索とその作用機構の解明

  川畑球一, 澤田圭介, 福田伊津子, 上田学, 川崎健吾, 山本憲朗, 芦田均

  2009, 日本食品科学工学会大会講演集, 56th


• 3S10p03 Structure-activity relationships of suppressive effects of anthraquinones on activation of an aryl hydrocarbon receptor

  FUKUDA Itsuko, KAWASE Masaya, ASHIDA Hitoshi

  日本生物工学会, 2009, 日本生物工学会大会講演要旨集, 21, 258 - 258, Japanese


• POLYPHENOLS PROMOTE GLUCOSE UPTAKE IN SKELETAL MUSCLE CELLS ACCOMPANIED BY THE TRANSLOCATION OF GLUCOSE TRANSPORTER 4 ON PLASMA MEMBRANE

  Hitoshi Ashida, Manabu Ueda, Kyuichi Kawabata, Itsuko Fukuda

  2009, ANNALS OF NUTRITION AND METABOLISM, 55, 278 - 279, English

  Summary international conference


• パン酵母β-グルカンの整腸作用について

  FUKUDA Itsuko, KODOI Rie

  2009, 日本醸造教会誌, 104(12) (12), 939 - 943, Japanese

  Introduction scientific journal


• An update on the dietary ligands of the AhR

  Hitoshi Ashida, Shin Nishiumi, Itsuko Fukuda

  Nov. 2008, EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 4(11) (11), 1429 - 1447, English

  [Refereed]

  Book review


• ヨモギ抽出物の高血糖・肥満抑制効果について

  金本優杞, 上田学, 田中彰人, 川崎健吾, 山本憲朗, 福田伊津子, 芦田均

  2008, 日本栄養・食糧学会大会講演要旨集, 62nd


• ヨモギ抽出物の骨格筋糖取込促進作用およびインスリン抵抗性抑制効果について

  川崎健吾, 上田学, 金本優杞, 山本憲朗, 室崎伸二, 福田伊津子, 芦田均

  2008, 日本香辛料研究会講演要旨集, 23rd


• 高脂肪食摂取マウスにおけるヨモギ抽出物のインスリン抵抗性予防作用

  金本優杞, 上田学, 川崎健吾, 山本憲朗, 福田伊津子, 芦田均

  2008, 日本食品科学工学会大会講演集, 55th


• ダイオキシン類の生物学的超微量測定法

  Itsuko Fukuda, Hitoshi Ashida

  日本工業出版, 2008, 検査技術, 13(8),15-20(8) (8), 15 - 20, Japanese

  Introduction scientific journal


• インジゴイドによるアリール炭化水素受容体の形質転換抑制効果

  西海信, 山本憲朗, 福田伊津子, 向井理恵, 吉田健一, 芦田均

  2007, 日本農芸化学会大会講演要旨集, 2007


• Suppressive effects of flavonoids on activation of the aryl hydrocarbon receptor induced by dioxins

  Itsuko Fukuda, Hitoshi Ashida

  Sep. 2006, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 232, 112 - 112, English

  Summary international conference


• 筋肉細胞における(-)-エピガロカテキンガレートによるグルコースの取り込み亢進作用機構について

  上田 学, 西海 信, 向井 理恵, Yap Angeline, 福田 伊津子, 吉田 健一, 芦田 均

  (公社)日本栄養・食糧学会, Apr. 2006, 日本栄養・食糧学会大会講演要旨集, 60回, 206 - 206, Japanese


• 芳香族炭化水素により誘導されるアリール炭化水素受容体の形質転換に対するカカオポリフェノールの抑制効果

  向井 理恵, 夏目 みどり, 越阪部 奈緒美, 西海 信, 福田 伊津子, 吉田 健一, 芦田 均

  (公社)日本栄養・食糧学会, Apr. 2006, 日本栄養・食糧学会大会講演要旨集, 60回, 235 - 235, Japanese


• カテキンのダイオキシン毒性予防作用

  福田 伊津子, 芦田 均

  日本生物工学会, 2004, 生物工学会誌, 82(10) 477-480(10) (10), 477 - 480, Japanese

  Others


• アリル炭化水素受容体の形質転換作用における食品因子とダイオキシンとの比較

  小土井理恵, 福田伊津子, 薮下善行, 西海信, 山本憲朗, 金沢和樹, 芦田均

  2003, 日本農芸化学会大会講演要旨集, 2003

• ポリフェノールの科学 : 基礎化学から健康機能まで

  寺尾, 純二, 下位, 香代子, 越阪部, 奈緒美, 榊原, 啓之, 中村, 宜督, 三好, 規之, 室田, 佳恵子

  Joint work, 第10章 腸内細菌叢との関わり, 朝倉書店, Nov. 2023, Japanese, ISBN: 9784254103038


• 環境汚染物質除去作用: 「茶の事典」

  FUKUDA Itsuko, ASHIDA Hitoshi

  Joint work, 朝倉書店, 2017, Japanese

  Scholarly book


• Modulation of drug-metabolizing enzymes and transporters by polyphenols as one of the anti-carcinogenic effects. In "Polyphenols in Human Health and Diseases": Vol. 2. Eds by Ronald Ross Watson, Victor R. Preedy, and Sherma Zibadi. Chapter 86, pp. 1127-11

  FUKUDA Itsuko, ASHIDA Hitoshi

  Joint work, Academic Press, 2013, English

  Scholarly book


• Suppressive Effects of Flavonoids on Activation of the Aryl Hydrocarbon Receptor Induced by Dioxins, in “Functional Food and Health”, Chapter 31, Eds. by Takayuki Shibamoto, Kazuki Kanazawa, Fereidoon Shahidi, and Chi-Tang Ho., ACS symposium series No.993

  FUKUDA Itsuko, ASHIDA Hitoshi

  Joint work, American Chemical Society, 2011, English

  Scholarly book


• 熱中性子放射化分析による定量分析、「メタルバイオテクノロジーによる環境保全と資源回収 ～新元素戦略の新しいキーテクノロジー～」、吉田和哉名誉監修・植田充美、池道彦監修、pp. 263-270.

  KAWASE Masaya, ASHIDA Hitoshi, FUKUDA Itsuko

  Joint work, シーエムシ－出版, 2009, Japanese

  Scholarly book


• メタルバイオテクノロジーによる環境保全と資源回収 ～新元素戦略の新しいキーテクノロジー～

  Masaya Kawase, Hitoshi Ashida, Itsuko Fukuda

  Joint work, シーエムシー出版, 2009, Japanese

  Scholarly book


• Suppressive effects of flavonoids on activation of the aryl hydrocarbon receptor induced by dioxins. In: Functional Food and Health, T. Shibamoto, K. Kanazawa, F. Shahidi, and C.-T. Ho, eds., pp. 369-374.

  Itsuko Fukuda, Hitoshi Ashida

  Joint work, American Chemical Society, 2008, English

  Scholarly book


• 「芳香族炭化水素の毒性発現抑制作用への可能性」茶の効能と応用開発，伊勢村護監修，pp. 316-326．

  Itsuko Fukuda, Hitoshi Ashida

  Joint work, シー・エム・シー出版, 2006, Japanese

  Scholarly book


• Studies on Suppression of the Dioxin Toxicity by Food Factors

  FUKUDA ITSUKO

  Single work, 博士論文, 2005, English

  Scholarly book


• Suppression of Cytochrome P4501A Subfamily in Mouse Liver by Oral Intake of Polysaccharides from Mushrooms, Lentinus edodes and Agaricus blazei.(Chapter 21, 235-248), In "Food Factors in Health Promotion andDisease Prevention"

  Hitoshi Ashida, Takashi Hashimoto, Yuji Nonaka, Itsuko Fukuda, Kazuki Kanazawa, Genichi Danno, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno

  Others, American Chemical Society, 2003, English

  Scholarly book


• Suppression of Cytochrome P4501A Subfamily in Mouse Liver by Oral Intake of Polysaccharides from Mushrooms, Lentinus edodes and Agaricus blazei.(Chapter 21, 235-248)

  Hitoshi Ashida, Takashi Hashimoto, Yuji Nonaka, Itsuko Fukuda, Kazuki Kanazawa, Gen-ichi Danno, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno

  Joint work, American Chemical Society, 2003, English

  Scholarly book


• Green Tea Extracts Prevent the Dioxin Toxicity through the Suppression of Transformation of the Aryl Hydroarbon Receptor.(Chapter 11, pp.119-127), In "Food Factors in Health Promotion andDisease Prevention"

  Itsuko Fukuda, Atsushi Kaneko, Yoshiyuki Yabushita, Iwao Sakane, Takami Kakuda, Kazuki Kanazawa, Genichi Danno, Hitoshi Ashida

  Others, American Chemical Society, 2003, English

  Scholarly book


• Green Tea Extracts Prevent the Dioxin Toxicity through the Suppression of Transformation of the Aryl Hydroarbon Receptor.(Chapter 11, pp.119-127)

  FUKUDA ITSUKO, ATSUSHI KANEKO, YOSHIYUKI YABUSHITA, IWAO SAKANE, TAKAMI KAKUDA, KAZUKI KANAZAWA, GEN-ICHI DANNO, ASHIDA HITOSHI

  Joint work, In "Food Factors in Health Promotion and Disease Prevention", 2003, English

  Scholarly book

• 腸内細菌Bacteroides thetaiotaomicronによる食物繊維の資化性に関する研究

  篠原 涼平, 古根 隆広, 生田 直子, 佐々木 大介, 佐々木 建吾, 福田 伊津子, 大澤 朗, 坂本 憲広

  第70回日本生物工学会大会, Sep. 2018, Japanese, 関西大学 千里山キャンパス, Domestic conference

  Poster presentation


• in vitro培養系ヒト腸内細菌叢モデル（KUHIMM） を用いた難消化性食物繊維の影響評価

  SASAKI DAISUKE, SASAKI KENGO, IKUTA NAOKO, FUKUDA ITSUKO, KONDO AKIHIKO, OSAWA RO

  第70回日本生物工学会大会, Sep. 2018, Japanese, 関西大学 千里山キャンパス, Domestic conference

  Poster presentation


• In vitro培養系ヒト腸内細菌叢モデルによる潰瘍性大腸炎患者の代謝プロファイル異常の検出

  SASAKI KENGO, INOUE JUN, HOSHI NAMIKO, SASAKI DAISUKE, FUKUDA ITSUKO, KONDO AKIHIKO, OSAWA RO

  第70回日本生物工学会大会, Sep. 2018, Japanese, 関西大学 千里山キャンパス, Domestic conference

  Poster presentation


• Lactobacillus plantarum 22A-3 enhances anti-oxidant activity of (-)-epigallocatechin-3-gallate in C57BL/6J mice

  FUKUDA ITSUKO, TAKEMORI AYAKA, HAYASHI TAEKO, OSAWA RO

  The 6th International Conference on Food Factors (ICoFF 2015), Nov. 2015, English, COEX, Seoul, Republic of Korea, International conference

  Poster presentation


• ヒト腸管培養モデルを用いたイヌリン型フルクタンの有益 効果の検証

  高木 理沙, 野本 竜平, FUKUDA ITSUKO, OSAWA RO

  2015年度 日本乳酸菌学会泊まり込みセミナー, May 2015, Japanese, サンライズ淡路, Domestic conference

  Oral presentation


• Inhibitory effect of cardamonin on transformation of aryl hydrocarbon receptor

  HE Chao, ZHANG Tianshun, YAMAMOTO Norio, FUKUDA Itsuko, ASHIDA Hitoshi

  The 33rd International Symposium on Halogenated Persistent Organic Pollutants and POPs (DIOXIN2013), 2013, English, Daegu, Korea, International conference

  Poster presentation


• 蛍光分析法を利用したアシル化カテキンと血清アルブミンの相互作用の検討

  HAYASHIBARA Kaori, JIANG Songyan, KITANO Rei, FUKUDA Itsuko, MIZUSHINA Yoshiyuki, KAIHATSU Kunihiro, KATO Nobuo, KAWASE Masaya, ASHIDA Hitoshi

  第59回日本食品科学工学会, 2012, Japanese, 札幌, Domestic conference

  Oral presentation


• マウスおよびラットにおける黒大豆種皮抽出物の蛍光毒性評価

  FUKUDA Itsuko, YOSHIDA Tadashi, TODA Toshiya, TSUDA Takanori, ASHIDA Hitoshi

  第66回日本栄養・食糧学会大会, 2012, Japanese, 仙台, Domestic conference

  Oral presentation


• カルコン類によるアリール炭化水素受容体の活性化抑制効果について

  HE Chao, FUKUDA Itsuko, ASHIDA Hitoshi

  第17回日本フードファクター学会学術集会・第9回日本カテキン学会総会合同大会, 2012, Japanese, 静岡, Domestic conference

  Oral presentation


• Induction of the multidrug-resistant Mdr1b mediatedby aryl hydrocarbon receptor in mouse hepatoma Hepa-1c1c7 cells

  NOMURA Ayano, KINEHARA Masaki, FUKUDA Itsuko, ASHIDA Hitoshi

  The 32nd International Symposium on Halogenated Persistent Organic Pollutants and POPs (DIOXIN2012), 2012, English, ケアンズ, International conference

  Poster presentation


• Application of a southwestern-chemistry based ELISA to evaluation of dioxins in the farm products

  FUKUDA Itsuko, ASHIDA Hitoshi

  The 32nd International Symposium on Halogenated Persistent Organic Pollutants and POPs (DIOXIN2012), 2012, English, ケアンズ, International conference

  Poster presentation


• 3-メチルコラントレンによるアリール炭化水素受容体を介した多剤耐性遺伝子mdr1bの転写調節

  NOMURA Ayano, KINEHARA Masaki, FUKUDA Itsuko, ASHIDA Hitoshi

  2012年度日本農芸化学会関西支部大会(第476回講演会), 2012, Japanese, 亀岡, Domestic conference

  Oral presentation


• 医薬品類と水系フミン物質の吸着

  國宗 実穂, 森 寿代, FUKUDA ITSUKO, ASHIDA HITOSHI, 藤嶽 暢英

  第20回環境化学討論会, Jul. 2011, Japanese, 日本環境化学会, 熊本, Domestic conference

  Poster presentation


• Cardamonin stimulates glucose uptake through translocation of glucose transporter-4 in L6 miotubes

  YAMAMOTO Norio, KAWABATA Kyuichi, SAWADA Keisuke, UEDA Manabu, FUKUDA Itsuko, KAWASAKI Kengo, MURAKAMI Akira, ASHIDA Hitoshi

  2011 International Conference on Food Factors (ICoFF2011), 2011, English, International conference

  Poster presentation


• 明日葉カルコン4-hydroxyderricinおよびxanthoangelolの糖取り込み促進作用とその分子機序の検討

  KAWABATA Kyuichi, IKEDA Kazunori, SAWADA Keisuke, FUKUDA Itsuko, KAWASAKI Kengo, YAMAMOTO Norio, ASHIDA Hitoshi

  日本農芸化学会2010年度大会, 2010, Japanese, Domestic conference

  Oral presentation


• 食品中の機能成分の体内金属動態に対する作用

  KAWASE Masaya, SAITO Tadashi, FUKUDA Itsuko, ASHIDA Hitoshi

  京都大学原子炉利用者講演会, 2010, Japanese, Domestic conference

  Oral presentation


• フラボノイドの体内動態と抗酸化能評価

  TSUTSUI Miki, FUKUDA Itsuko, ASHIDA Hitoshi

  日本農芸化学会2010年度大会, 2010, Japanese, Domestic conference

  Oral presentation


• グリコーゲンの消化酵素による分解性

  TAKATA Hitoki, KAJIURA Hideki, KAKUTANI Ryo, FURUYASHIKI Takashi, KURIKI Takashi, FUKUDA Itsuko, ASHIDA Hitoshi

  日本農芸化学会2010年度大会, 2010, Japanese, Domestic conference

  Oral presentation


• キャピラリー電気泳動法を利用したタンパク質・食品因子間相互作用の解析

  KITANO Rei, KAWASE Masaya, IHARA Ikko, FUKUDA Itsuko, ASHIDA Hitoshi

  第62回日本生物工学会, 2010, Japanese, Domestic conference

  Oral presentation


• キャピラリー電気泳動法を用いたタンパク質と食品因子との相互作用の解析

  KITANO Rei, FUKUDA Itsuko, KAWASE Masaya, ASHIDA Hitoshi

  日本農芸化学会2010年度大会, 2010, Japanese, Domestic conference

  Oral presentation


• 4-Hydroxyderricin and xanthoangelol stimulate glucose uptake in skeletal muscle cells via inducing GLUT4 translocation

  KAWABATA Kyuichi, SAWADA Keisuke, IKEDA Kazunori, FUKUDA Itsuko, KAWASAKI Kengo, YAMAMOTO Norio, ASHIDA Hitoshi

  PACIFICHEM2010(環太平洋国際化学会議), 2010, English, Domestic conference

  Poster presentation


• 腐植物質に対する医薬品類の収着

  森 寿代, 大谷 知也, FUKUDA ITSUKO, ASHIDA HITOSHI, 藤嶽 暢英

  日本腐植物質学会第25回講演会, Nov. 2009, Japanese, 日本腐植物質学会, 兵庫, Domestic conference

  Oral presentation


• 緑茶投与がラット体毛の重金属量に及ぼす影響

  FUKUDA Itsuko, KAWASE Masaya, SAITO Tadashi, MORIMOTO Syotaro, NAKANO Yukihiro, MUKAI Rie, ASHIDA Hitoshi

  日本農芸化学会2009年度大会, 2009, Japanese, Domestic conference

  Oral presentation


• 明日葉カルコン4-hydroxyderricinおよびxanthoangelolの血糖値調節作用

  KAWABATA Kyuichi, IKEDA Kazunori, SAWADA Keisuke, FUKUDA Itsuko, KAWASAKI Kengo, YAMAMOTO Norio, ASHIDA Hitoshi

  第14回日本フードファクター学会, 2009, Japanese, Domestic conference

  Poster presentation


• 茶の白色脂肪蓄積抑制作用におけるカフェインとカテキンの寄与について

  IMADA Sayuri, IKEDA Kazunori, SAKANE Iwao, SAWAMURA Shinichi, FUKUDA Itsuko, ASHIDA Hitoshi

  2009年日本農芸化学会関西・西日本合同支部大会, 2009, Japanese, Domestic conference

  Oral presentation


• 細胞内糖取り込みを誘導するポリフェノールの探索とその作用機構の解明

  KAWABATA Kyuichi, SAWADA Keisuke, FUKUDA Itsuko, UEDA Manabu, KAWASAKI Kengo, YAMAMOTO Norio, ASHIDA Hitoshi

  日本食品学工学会第56回大会, 2009, Japanese, Domestic conference

  Oral presentation


• 高脂肪食摂取マウスにおける酵素合成グリコーゲンの脂質代謝に対する影響

  IMADA Sayuri, KANAMOTO Yuki, FUKUDA Itsuko, FURUYASHIKI Takashi, TAKATA Hiroki, ASHIDA Hitoshi

  第63回日本栄養・食糧学会大会, 2009, Japanese, Domestic conference

  Oral presentation


• 紅茶糖尿病予防および改善効果について

  IMADA Sayuri, SAKANE Iwao, SAWAMURA Shinichi, SAGESAKA Yuko, FUKUDA Itsuko, ASHIDA Hitoshi

  第14回日本フードファクター学会, 2009, Japanese, Domestic conference

  Poster presentation


• 筋肉組織における糖輸送担体GLUT4の細胞膜移行に及ぼすプロポリス抽出物の影響について

  UEDA Manabu, SAWADA Keisuke, KASHIWADA Daisuke, FUKUDA Itsuko, YOSHIDA Ken-ichi, ASHIDA Hitoshi

  日本食品学工学会第56回大会, 2009, Japanese, Domestic conference

  Oral presentation


• 筋肉細胞におけるアシル化カテキンによるGLUT4膜移行促進効果とその作用機構について

  UEDA Manabu, FUSE Naoya, MIZUSHINA Hiroyuki, YOSHIDA Hiromi, FUKUDA Itsuko, YOSHIDA Kenichi, ASHIDA Hitoshi

  第14回日本フードファクター学会, 2009, Japanese, Domestic conference

  Poster presentation


• ヨモギ抽出物によるGLUT4膜移行促進作用機構の解明

  UEDA Manabu, KAWASKI Kengo, YAMAMOTO Norio, MUROSAKI Shinji, FUKUDA Itsuko, YOSHIDA Ken-ichi, ASHIDA Hitoshi

  日本農芸化学会2009年度大会, 2009, Japanese, Domestic conference

  Oral presentation


• ショウガ科植物成分カルダモニンおよびアルピネチンの筋細胞におけるGLUT4依存的な糖取込促進作用

  YAMAMOTO Norio, KAWABATA Kyuichi, KAWASAKI Kengo, FUKUDA Itsuko, ASHIDA Hitoshi

  第24回日本香辛料研究会, 2009, Japanese, Domestic conference

  Oral presentation


• アントラキノン類のアリール炭化水素受容体活性化抑制作用の構造活性相関について

  FUKUDA Itsuko, KAWASE Masaya, ASHIDA Hitoshi

  第61回日本生物工学会, 2009, Japanese, Domestic conference

  Poster presentation


• Safety assessment of extract of black soybean seed coat: Acute and chronic toxicity studies

  TSUTSUI Miki, FUKUDA Itsuko, YOSHIDA Tadashi, TODA Toshiya, TSUDA Takanori, ASHIDA Hitoshi

  The 5th International Workshop on Anthocyanins, 2009, English, International conference

  Poster presentation


• Preventive effects of black soybean seed coat extract on obesity and hyperglycemia in high-fat diet-fed mice

  ASHIDA Hitoshi, KANAMOTO Yuki, KAWABATA Kyuichi, NANBA Fumio, YOSHIDA Tadashi, FUKUDA Itsuko, TSUDA Takanori, TODA Toshiya

  The 4th International Conference on Polyphenols and Health, 2009, English, International conference

  Poster presentation


• Polyphenols promote glucose uptake in skeletal muscle cells accompanied by the translocation of glucose transporter 4 on plasma membrane

  ASHIDA Hitoshi, UEDA Manabu, KAWABATA Kyuichi, FUKUDA Itsuko

  19th International Congress of Nutrition, 2009, English, International conference

  Poster presentation


• L6筋管細胞におけるアシルカテキンによるインスリン応答性糖輸送担体(GLUT4)の細胞膜移行促進効果

  FUSE Naoya, UEDA Manabu, FUKUDA Itsuko, YOSHIDA Kenichi, MIZUSHINA Hiroyuki, YOSHIDA Hiromi, ASHIDA Hitoshi

  日本農芸化学会2009年度大会, 2009, Japanese, Domestic conference

  Oral presentation


• Epigallocatechin-3-gallate regulate glucose metabolism in skeletal muscle cells

  UEDA Manabu, KAWABATA Kyuichi, FUKUDA Itsuko, YOSHIDA Ken-ichi, ASHIDA Hitoshi

  The 4th International Conference on Polyphenols and Health, 2009, English, International conference

  Poster presentation


• 4-Hydroxyderricin and xanthoangelol, prenylated chalcones from Ashitaba (Angelica keiskei), stimulate glucose uptake in skeletal muscle cells via inducing GLUT4 translocation

  KAWABATA Kyuichi, SAWADA Keisuke, FUKUDA Itsuko, KAWASAKI Kengo, YAMAMOTO Norio, ASHIDA Hitoshi

  The 4th International Conference on Polyphenols and Health, 2009, English, International conference

  Poster presentation


• Prevention of dioxin toxicity by food factores

  ASHIDA Hitoshi, NISHIUMI Shin, MUKAI Rie, YOSHIDA Kenichi, FUKUDA Itsuko

  2005 International chemical congress of pacific basin societies (PACIFICHEM 2005) December 15th-20th, Programp.4TECH, #162, Abstract is available on CD., Dec. 2005, English, 未記入, Honolulu, Hawaii, International conference

  Oral presentation


• 茶の飲用はアリール炭化水素受容体の活性化を抑制する

  福田 伊津子, 西海 信, 坂根 巌, 藪下 善行, 沢村 信一, 金沢 和樹, 吉田 健一, 芦田 均

  2005年度日本農芸化学会大会講演要旨集, Mar. 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• 腸管上皮を透過しダイオキシンの毒性発現を抑制しうるフラボノイド類の検索及び解析

  濱田 美影, 夏目 やよい, 薩 秀夫, 西海 信, 福田 伊津子, 芦田 均, 清水 誠

  日本動物細胞工学会2005年度大会 講演要旨集p.64, 2005, Japanese, 日本動物細胞工学会, 東京, Domestic conference

  Oral presentation


• モロヘイヤはアリール炭化水素受容体の形質転換を抑制する

  西海 信, 福田 伊津子, 向井 理恵, 吉田 健一, 芦田 均

  日本動物細胞工学会2005年度大会 講演要旨集p.58, 2005, Japanese, 日本動物細胞工学会, 東京, Domestic conference

  Oral presentation


• フラボノイド類とアリール炭化水素受容体との相互作用について

  向井 理恵, 福田 伊津子, 西海 信, 川瀬 雅也, 吉田 健一, 芦田 均

  日本農芸化学会2005年度関西・中四国・西日本支部合同大会 講演要旨集p.75, 2005, Japanese, 日本農芸化学会, 大阪, Domestic conference

  Oral presentation


• ダイオキシン類の毒性発現を抑制するフラボノイド類の検索及び解析

  濱田 美影, 夏目 やよい, 薩 秀夫, 西海 信, 福田 伊津子, 芦田 均, 清水 誠

  日本農芸化学会2005年度大会 大会講演要旨集p.274, 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• カテキンがインスリン応答性糖輸送活性に及ぼす影響

  青木 由葵子, 福田 伊津子, 吉田 健一, 芦田 均

  日本農芸化学会2005年度大会 大会講演要旨集p.285, 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• インジゴイドがアリール炭化水素受容体の形質転換に及ぼす影響について

  西海 信, 山本 憲朗, 小土井 理恵, 福田 伊津子, 室崎 伸二, 吉田 健一, 芦田 均

  第10回日本フードファクター学会（JSoFF） 講演要旨集p.61, 2005, Japanese, 日本フードファクター学会, 岡山, Domestic conference

  Oral presentation


• アリール炭化水素受容体複合体に対するフラボノイド類の作用機序の解明

  向井 理恵, 福田 伊津子, 西海 信, 川瀬 雅也, 吉田 健一, 芦田 均

  第28回日本分子生物学会年会 講演要旨集p.479, 2005, Japanese, 日本分子生物学会, 博多, Domestic conference

  Poster presentation


• アリール炭化水素受容体の形質転換に影響をおよぼす植物の検索

  西海 信, 細川 敬三, 菱田 敦之, 向井 理恵, 福田 伊津子, 吉田 健一, 芦田 均

  日本農芸化学会2005年度大会 大会講演要旨集p.118, 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• (-)-エピガロカテキンガレートとアリール炭化水素受容体との相互作用について

  向井 理恵, 福田 伊津子, 西海 信, 川瀬 雅也, 吉田 健一, 芦田 均

  日本農芸化学会2005年度大会 大会講演要旨集p.99, 2005, Japanese, 日本農芸化学会, 札幌, Domestic conference

  Oral presentation


• 茶カテキンと受容体との相互作用について

  福田 伊津子

  第3回ポリフェノール研究会（組織保存液開発プレベンチャーグループ研究会）, 2004, Japanese, ポリフェノール研究会, 未記入, Domestic conference

  Oral presentation


• 神戸大学農学部生物機能化学科生物機能開発化学教育研究分野

  芦田 均, 吉田 健一, 福田 伊津子, 木根原 匡希, 久保 麻友子, 西海 信, 青木 由葵子, 向井 理恵

  近畿地域アグリビジネス創出フェア, 2004, Japanese, 未記入, 未記入, Domestic conference

  Oral presentation


• プロポリスはアリール炭化水素受容体の活性化を抑制する

  福田 伊津子, 西海 信, PARK Yong K, P-GUZMAN Julio, SATO Helia H, Pastore Glaucia M, 芦田 均

  2004年度日本農芸化学会本大会, 2004, Japanese, 日本農芸化学会, 未記入, Domestic conference

  Oral presentation


• ブラジル産プロポリスはアリール炭化水素受容体の活性化を抑制する

  福田 伊津子, Yong K.Park, 西海 信, 芦田 均

  2004年度日本農芸化学会大会, 2004, Japanese, 日本農芸化学会, 広島, Domestic conference

  Oral presentation


• パン酵母β-グルカン（BBG)のコレステロール吸収阻害効果について

  福田 伊津子, 小土井 理恵, 久保 麻友子, 岡本 隆志, 芦田 均, 藤田 剛

  第58回日本栄養・食料学会, 2004, Japanese, 日本栄養・食料学会, 仙台, Domestic conference

  Oral presentation


• ダイオキシン類のリスク評価のための新規測定法の構築

  西海 信, 福田 伊津子, 向井 理恵, 芦田 均

  2004年度日本農芸化学会本大会, 2004, Japanese, 日本農芸化学会, 未記入, Domestic conference

  Oral presentation


• ダイオキシン類のリスク評価のための新規測定法の構築

  西海 信, 福田 伊津子, 向井 理恵, 芦田 均

  2004年度日本農芸化学会大会, 2004, Japanese, 日本農芸化学会, 広島, Domestic conference

  Oral presentation


• アントシアンはアリール炭化水素受容体の活性化を抑制しない

  向井 理恵, 福田 伊津子, 西海 信, 細川 敬三, 金沢 和樹, 芦田 均

  2004年度日本農芸化学会大会, 2004, Japanese, 日本農芸化学会, 広島, Domestic conference

  Oral presentation


• Tea has the potential to reduce the dioxin risk.

  FUKUDA Itsuko, SAKANE I, NISHIUMI Shin, SHIRASUGI I, SAWAMURA S, KANAZAWA Kazuki, YOSHIDA Kenichi, ASHIDA Hitoshi

  International Conference of O-CHA(tea) Culture and Science., 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Tea has the potential to reduce the dioxin risk.

  FUKUDA Itsuko, SAKANE I, NISHIUMI Shin, SHIRASUGI Ichirou, SAWAMURA S, KANAZAWA Kazuki, YOSHIDA Kenichi, ASHIDA Hitoshi

  2004 International Conference On O-CHA(tea) Culture And Science, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Suppression of dioxin mediated aryl hydrocarbon receptor transformation by ethanolic extracts of proplis and its main botanical origin.

  PARK Y K, FUKUDA Itsuko, ASHIDA Hitoshi, NISHIUMI Shin, Julio Paredes-Guzman, Helia H Sato, Glaucia M Pastore

  The Institute of Food Techcologists 2004 Annual Meeting., 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Intake of green tea increases antioxidative potency in rats.

  SAKAKIBARA H, ASHIDA Hitoshi, FUKUDA Itsuko, FURUYASHIKI T, NONAKA Y, SANO T, KANAZAWA Kazuki

  International Conference of O-CHA(tea) Culture and Science., 2004, English, 未記入, 未記入, International conference

  Oral presentation


• Intake of green tea increases antioxidative potency in rats.

  SAKAKIBARA H, ASHIDA Hitoshi, FUKUDA Itsuko, FURUYASHIKI F, NONAKA Y, SANO T, KANAZAWA Kazuki

  2004 International Conference On O-CHA(tea) Culture And Science, 2004, English, 未記入, 未記入, International conference

  Oral presentation


• 野菜および果物抽出物によるダイオキシン毒性の抑制効果

  西海 信, 藪下 善行, 福田 伊津子, 小土井 理恵, 金沢 和樹, 芦田 均

  日本食品科学工学会第50回大会講演要旨集, Sep. 2003, Japanese, 日本食品科学工学会, 東京農業大学, Domestic conference

  Oral presentation


• 肝癌周囲硬変部におけるendoglin/CD105 発現の免疫組織化学的解析

  畑中 豊, 福田 伊津子, 西海 信, 神原 由季, 橋詰 薫, 足立 史朗, 谷 洋一, 芦田 均, 鈴木 敬一郎

  日本癌学会第62回総会総会記事, Sep. 2003, Japanese, 日本癌学会, 名古屋国際会議場, Domestic conference

  Oral presentation


• 野菜抽出物によるアリル炭化水素受容体形質転換抑制能について

  西海 信, 藪下 善行, 福田 伊津子, 小土井 理恵, 金沢 和樹, 芦田 均

  2003年度日本農芸化学会本大会講演要旨集, 2003, Japanese, 日本農芸化学会, 未記入, Domestic conference

  Oral presentation


• フラボノイドとアリル炭化水素受容体との相互作用について

  福田 伊津子, 小土井 理恵, 藪下 善行, 金沢 和樹, 芦田 均

  2003年度日本農芸化学会本大会講演要旨集, 2003, Japanese, 日本農芸化学会, 未記入, Domestic conference

  Oral presentation


• アリル炭化水素受容体を形質転換する食品因子とダイオキシンの作用との比較

  小土井 理恵, 福田 伊津子, 西海 信, 山本 憲朗, 金沢 和樹, 芦田 均

  2003年度日本農芸化学会本大会講演要旨集, 2003, Japanese, 日本農芸化学会, 未記入, Domestic conference

  Oral presentation


• アリール炭化水素受容体の活性化を測定するELISA の構築とこれを用いた食品成分のダイオキシン毒性抑制効果の評価

  福田 伊津子, 西海 信, 畑中 豊, 水野 雅史, 芦田 均

  第62回日本癌学会総会, 2003, Japanese, 日本癌学会, 名古屋国際会議場, Domestic conference

  Oral presentation

• 日本生物工学会


• 日本フードファクター学会


• 日本薬理学会


• 日本癌学会


• 日本食品科学・工学会


• 日本栄養・食糧学会


• 日本分子生物学会


• 日本農芸化学会

• Optimization of human intestinal microbiota model and construction of evaluation system of postbiotics

  福田 伊津子

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2022 - 31 Mar. 2025


• ファイトケミカルの腸内動態と腸内環境におよぼす影響の解明

  福田 伊津子

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• 腸内細菌を用いたニホンザル農地依存度の把握と加害レベル判定手法の確立

  清野 未恵子

  科学研究費補助金／基盤研究(B), Apr. 2017 - Mar. 2021

  Competitive research funding


• 農水産物中のダイオキシン類の生物学的測定法の開発とその適用

  福田 伊津子

  学術研究助成基金助成金／若手研究(B), Apr. 2013 - Mar. 2016, Principal investigator

  Competitive research funding


• アリール炭化水素受容体の食事性リガンドの分子制御機構と体内動態の解明

  福田 伊津子

  科学研究費補助金／若手研究(B), 2007, Principal investigator

  Competitive research funding

• ナリンゲニン誘導体、それを含有するグルコース取込み促進剤及び血糖値上昇抑制剤

  ASHIDA HITOSHI, YOSHIDA KEN-ICHI, FUKUDA ITSUKO

  特願2006-188931, 10 Jul. 2006, 大学長, 特許5061282, 17 Aug. 2012

  Patent right