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NAKAMURA Makoto
Graduate School of Medicine / Faculty of Medical Sciences
Professor

Researcher basic information

■ Research Areas
  • Life sciences / Ophthalmology

Research activity information

■ Award
  • May 2011 財団法人日本眼科学会, 日本眼科学会評議員会賞, 第115会日本眼科学会総会評議員会指名講演「緑内障性視神経症への挑戦．その基礎と臨床における三つの仮説の提唱
    Nakamura Makoto

  • Apr. 2007 ロート製薬株式会社, 第12回ロート賞, 網膜内インスリン情報伝達と神経変性眼疾患との関わり
    NAKAMURA MAKOTO

  • Sep. 2005 公益信託 須田緑内障治療研究奨励基金, 第18回須田学術奨励賞, Akt is activated via insulin / IGF-1 receptor in rat retina with episcleral vein cauterization. Brain Res 1022: 195-204, 2004
    NAKAMURA MAKOTO

  • Mar. 2003 財団法人上原記念生命科学財団, 上原記念生命科学研究奨励, 糖尿病の実験的緑内障眼に及ぼす影響
    Nakamura Makoto

  • Oct. 1997 日本神経眼科学会, 第９回日本神経眼科学会若手奨励賞, Evaluation of bilateral undefined optic neuropathy based on mitochondrial genetics. Neuro-opthalmology 16: 91-97, 1996
    Nakamura Makoto

■ Paper
  • Risa Caraher-Masuda, Mari Sakamoto, Mina Okuda, Fumio Takano, Sotaro Mori, Kaori Ueda, Akiyasu Kanamori, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: To report the 3-year outcomes of surgical bleb revision (SBR) with mitomycin C (MMC) for early scarring bleb after trabeculectomy (TLE). STUDY DESIGN: Retrospective observational study. METHODS: We included glaucoma patients aged ≧ 18 who underwent SBR with MMC within 6 months of their first TLE at Kobe University Hospital and were followed for at least 6 months. The primary outcome measure was the three-year success rate of SBR. We defined surgical success as: intraocular pressure (IOP) reduction ≧ 20% from baseline and 5 ≦ IOP ≦ 18 mmHg. Failure was defined when the IOP deviated from the criteria, when the eye required additional glaucoma surgery, and when the eye lost light perception. Complete success (CS) was success without glaucoma medications and qualified success (QS) was success with glaucoma medications. The secondary outcome measures included IOP, the number of glaucoma medications, mean deviation (MD), best corrected visual acuity (BCVA), corneal endothelial cell density (ECD), and surgical complications. RESULTS: Sixty-eight eyes of 68 patients were analyzed. The median interval between initial TLE and SBR was 2 months. Overall success rate at three-year after SBR were 45.1% and 9.6% for QS and CS, respectively. A greater number of medications used before TLE was a contributing factor to failure (P = 0.02). 22 eyes (32.4%) underwent additional glaucoma surgery, and 41 eyes (60.3%) were spared from additional glaucoma surgery within 3 years after SBR. The median IOP decreased form 24.0 mmHg to 11.0 mmHg 3 years after SBR, and the number of medications decreased from 4 to 2 (P < 0.01). MD remained unchanged, but BCVA and ECD decreased at 3years postoperatively. There were no serious complications of SBR. CONCLUSION: SBR may be an effective treatment option for early scarring blebs after TLE but is unsuccessful in eyes that have used many glaucoma medications prior to TLE.
    Nov. 2024, Japanese journal of ophthalmology, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yuto Iwaki, Sotaro Mori, Mina Okuda-Arai, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: This study investigated the association between one-year surgical outcomes following trabeculectomy and age, accounting for confounding factors. STUDY DESIGN: Retrospective observational study. METHOD: Analyzing data from 305 patients undergoing initial trabeculectomy from 2019 onward, we employed three approaches to adjust variables: stratified analysis, regression analysis, and propensity score matching. Surgical success at 1-year post-surgery was defined by two criteria: achieving intraocular pressure of between 5 and 15 mmHg with a ≥ 20% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion A); achieving intraocular pressure of between 5 and 12 mmHg with a ≥ 30% reduction compared to pre-surgery levels and no additional glaucoma surgery (Criterion B). RESULTS: Stratified analysis by age unveiled a significant increase in exfoliation glaucoma (XFG) and a trend towards shorter axial lengths with advancing age (both p < 0.0001). Older age groups were more likely to experience surgical failure in both Criterion A and B (p = 0.21, < 0.01). Univariate analysis showed age as a significant factor in surgical failure for Criterion A (p < 0.05) and a nearly significant factor for Criterion B (p = 0.12). However, this trend was not evident in multivariate analysis (p = 0.23/0.88), where XFG became a significant factor for surgical failure (both p < 0.001) in Criteria A and B. Propensity score matching revealed no significant differences in surgical success rates for Criteria A and B between younger and older patients (p = 1.00 and 0.88). CONCLUSION: Age is not a primary determinant of failure in trabeculectomy; however, the increasing incidence of XFG with aging suggests a potential for poorer outcomes.
    Oct. 2024, Japanese journal of ophthalmology, English, Domestic magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 高濃度フィブリノーゲンによるICAM-1経路を介した網膜組織傷害の検討
    曽谷 育之, 今井 尚徳, 山田 裕子, 北村 萌, 盛 崇太朗, 松宮 亘, 三木 明子, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2024, 日本眼科学会雑誌, 128(臨増) (臨増), 174 - 174, Japanese

  • Mina Arai-Okuda, Yusuke Murai, Hidetaka Maeda, Akiyasu Kanamori, Takako Miki, Tomoko Naito, Kazunobu Sugihara, Michihiro Kono, Masaki Tanito, Hiromitsu Onoe, Kazuyuki Hirooka, Yoshiaki Kiuchi, Masakazu Shinohara, Sentaro Kusuhara, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    To investigate the association between lactate metabolism and glaucoma, we conducted a multi-institutional cross-sectional clinical study and a retinal metabolomic analysis of mice with elevated intraocular pressure (IOP) induced by intracameral microbead injection. We compared lactate concentrations in serum and aqueous humor in age-matched 64 patients each with primary open-angle glaucoma (POAG) and cataract. Neither serum nor aqueous humor lactate concentrations differed between the two groups. Multiple regression analysis revealed that only body mass index showed a significant positive correlation with serum and aqueous humor lactate concentration in POAG patients (rs = 0.376, P = 0.002, and rs = 0.333, P = 0.007, respectively), but not in cataract patients. L-Lactic acid was one of the most abundantly detected metabolites in mouse retinas with gas chromatography and mass spectrometry, but there were no significant differences among control, 2-week, and 4-week IOP elevation groups. After 4 weeks of elevated IOP, D-glucose and L-glutamic acid ranked as the top two for a change in raised concentration, roughly sevenfold and threefold, respectively (ANOVA, P = 0.004; Tukey-Kramer, P < 0.05). Glaucoma may disrupt the systemic and intraocular lactate metabolic homeostasis, with a compensatory rise in glucose and glutamate in the retina.
    Feb. 2024, Scientific reports, 14(1) (1), 3683 - 3683, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Aya Chubachi-Kamimura, Akiko Miki, Mayuka Hayashida-Hirano, Maya Kishimoto-Kishi, Mina Okuda, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    This study investigated aniseikonia after reduced-fluence photodynamic therapy (RFPDT) for central serous chorioretinopathy (CSC). We examined 48 eyes of 48 patients (38 men; mean age, 49.2 ± 9.9 years) with CSC resolved after RFPDT. Horizontal and vertical aniseikonia were measured using the New Aniseikonia Test at baseline, 6 months, and 12 months after RFPDT. The maximum absolute value of the horizontal and vertical measurements indicated the aniseikonia score. The aniseikonia score was 2.2 ± 2.3 at 6 months and 2.2 ± 2.0 at 12 months after RFPDT, both of which improved significantly from the baseline score of 4.1 ± 2.9 (P < 0.05 and P < 0.01, respectively). The 12-month aniseikonia score significantly correlated with the baseline aniseikonia score (P = 0.047), outer nuclear thickness at baseline (P = 0.027) and 12 months after RFPDT (P = 0.014), baseline SRD area (P = 0.005), and ellipsoid zone disruption at 12 months after RFPDT (P = 0.021). In multivariate analysis, baseline serous retinal detachment (SRD) area (P = 0.034) was significantly associated with aniseikonia score at 12 months after RFPDT. Eyes with a larger SRD area might have higher aniseikonia scores even after SRD resolution following RFPDT.
    Oct. 2023, Scientific reports, 13(1) (1), 17133 - 17133, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mina Okuda-Arai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: The impact of various preoperative glaucoma medications on Schlemm's canal surgery outcomes remains unclear. This study aimed to investigate the impact of preoperative glaucoma medications on the postoperative 1-year outcomes of μTLO. METHODS: We analyzed the medical records of 218 patients who underwent their first μTLO to investigate the 1-year postoperative outcomes. Cox proportional hazard regression analysis was performed with surgical failure as the dependent variable and each type of preoperative medication as the independent variable. We also compared the 1-year outcomes of μTLO between users and non-users of specific medications using propensity score matching. Surgical success was defined as a postoperative intraocular pressure ranging from 5 to 21 mmHg, a ≥20% reduction in IOP from baseline, and no additional glaucoma surgery within 1 year postoperatively. RESULTS: The Cox proportional hazard analysis showed that all drugs that do not increase the conventional outflow exhibited hazard ratios greater than 1.0, and the preoperative use of β-blockers and oral CAI was a significant surgical risk factor (hazard ratio: 2.65 and 2.45, p = 0.04 and <0.001). In the propensity score matching analysis, success rates at 1 year postoperatively were 55/85, 54/79, 60/73, and 40/76% for users/non-users of β-blockers, topical CAIs, an alpha-2 adrenergic agonist, and an oral CAI, respectively. Kaplan-Meier survival curves in these comparisons also demonstrated that preoperative β-blockers and oral CAI use were significant surgical risks (p = 0.01, <0.001). CONCLUSION: Our study suggests that preoperative medications that do not involve conventional pathway outflow have a detrimental effect on subsequent Schlemm's canal surgery outcomes.
    Sep. 2023, Acta ophthalmologica, English, International magazine
    Scientific journal

  • 原発開放隅角緑内障と血清・前房水乳酸濃度の関連についての検討
    荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 金森 章泰, 前田 秀高, 三木 貴子, 内藤 知子, 尾上 弘光, 廣岡 一行, 河野 通大, 杉原 一暢, 谷戸 正樹, 中村 誠
    日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 197 - 197, Japanese

  • 線維柱帯切開術(眼内法)術後早期に施行された線維柱帯切除術の術後1年成績
    岡 隼生, 坂本 麻里, 荒井 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2023, 日本緑内障学会抄録集, 34回, 160 - 160, Japanese

  • Mina Okuda, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: We have previously demonstrated that prolonged use of glaucoma medications was associated with a poor surgical outcome of ab interno trabeculotomy (µTLO). Given that almost all types of glaucoma eye drop either enhance the drainage through the uveoscleral pathway or reduce aqueous humor production, we hypothesized that prolonged use of these medications might cause disuse atrophy of the conventional pathway. In contrast, ripasudil increases the conventional outflow and eventually shows a favorable outcome of µTLO. This study aimed to evaluate the effect of ripasudil use on µTLO outcomes. METHOD: The medical charts of 218 patients who underwent µTLO were analyzed retrospectively. We compared the 1-year outcome between ripasudil users versus nonusers by using propensity score matching. We set the covariates as age, sex, glaucoma types, preoperative intraocular pressure (IOP), the mean deviation values of visual field tests, the presence or absence of concomitant cataract surgery, trabecular meshwork incision range, the presence or absence of any glaucoma medication except ripasudil and duration of glaucoma medical therapy. Success was defined as a postoperative IOP between 5 and 21 mmHg, a ≥ 20% IOP reduction from baseline, and no additional glaucoma surgery at postoperative 1 year. RESULT: Fifty-seven patients each were allocated to the ripasudil users or nonusers. The 1-year success rates were 74% in ripasudil users and 51% in nonusers (p = 0.01). Kaplan‒Meier survival curves also showed that the ripasudil users had a higher survival distribution (p = 0.01). CONCLUSION: The patients who took ripasudil showed a favorable 1-year outcome of µTLO.
    Sep. 2023, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 261(9) (9), 2603 - 2610, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hideaki Toyokuni, Mari Sakamoto, Kaori Ueda, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: To evaluate the reproducibility of the imo binocular random single-eye test (BRSET) and Humphrey Field Analyzer (HFA) monocular test in patients with glaucoma. STUDY DESIGN: Retrospective observational study. METHODS: We measured the visual fields (VF) of patients with glaucoma using the BRSET and HFA. All tests were repeated two months later. Mean sensitivity (MS), mean deviation (MD), sensitivity at each test location, and reliability indices were compared between the test days. Wilcoxon signed-rank test, interclass correlation coefficient (ICC), correlation coefficients, and Bland-Altman plots were generated for analysis. RESULTS: We analyzed the VFs of 46 patients with glaucoma. There were no test-retest differences for MS and MD, and ICCs were > 0.9 for MS and MD in both perimeters. Inter-test correlations for MS and MD were high. The limits of agreement (LoAs) (lower, upper limit) between test days for MS were (- 3.4, 4.0) for BRSET and (-3.3, 3.0) for HFA. The LoA for MD was (- 3.3, 3.8) for BRSET and (- 3.2, 2.9) for HFA. Sensitivity at each testing location was more variable between testing days for BRSET than for HFA. For reliability indices, LoAs between testing days were wider for BRSET than for HFA. CONCLUSION: The imo BRSET showed similar reproducibility to HFA in MS and MD. However, sensitivity at each test location varied more for BRSET than for HFA. Further studies are needed to verify the reproducibility of the imo BRSET.
    Sep. 2023, Japanese journal of ophthalmology, 67(5) (5), 578 - 589, English, Domestic magazine
    Scientific journal

  • Maya Kishi, Akiko Miki, Aya Kamimura, Mina Okuda, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    To evaluate the functional and anatomical effects of switching to faricimab for patients with neovascular age-related macular degeneration (nAMD) refractory to intravitreal aflibercept, this retrospective study evaluated patients with nAMD who received intravitreal injections of aflibercept (IVA) every <8 weeks and were switched to faricimab. After switching, the patients were treated with a treatment and extended regimen that started with the interval just before switching and received at least three injections. We evaluated changes in the best-corrected visual acuity (BCVA), central retinal thickness (CRT), central choroidal thickness (CCT), treatment interval, and presence of retinal fluid. Overall, 55 eyes from 55 patients were examined. After three injections of faricimab, the BCVA and CCT did not change significantly. However, the CRT decreased significantly (p < 0.05), the injection interval was significantly extended (7.5 ± 2.3 vs. 5.9 ± 1.5 weeks, p < 0.01), and the rates of the presence of intraretinal fluid and subretinal fluid decreased significantly to 16.4% and 40% of eyes, respectively (both p < 0.01). An ocular adverse event (retinal pigment epithelium tear) developed in one eye. Switching to faricimab was effective for anatomic changes. It may be an additional treatment option for some eyes refractory to IVA.
    Aug. 2023, Journal of clinical medicine, 12(15) (15), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yasuyuki Sotani, Hisanori Imai, Yukako Iwane, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    To report the usefulness of intraoperative real-time adjustment of intraocular lens (IOL) tilt during the intrascleral fixation with intraoperative optical coherence tomography (iOCT) as a clinical evaluation and investigate the factors contributing to IOL tilt using iOCT as an experimental evaluation. Retrospective cohort study and experimental research. As a clinical evaluation, the medical records of 43 eyes of 41 patients who underwent intrascleral IOL fixation combined with real-time iOCT observation were retrospectively reviewed. As an experimental evaluation, in order to investigate the factors contributing to IOL tilt, the four experiments were performed using iOCT. The mean IOL tilt angle (°) at the end of surgery and 3 months after surgery were 1.81 ± 1.15 and 2.10 ± 1.66, respectively (p = 0.46). No apparent intra- or postoperative complications occurred during the follow-up period. The experimental evaluation indicated that the IOL tilt was influenced by the insertion angle of the haptic in the vertical direction. The mean IOL tilt angle (°) was 1.94 ± 0.09, 4.67 ± 0.11, 8.90 ± 0.11, and 15.78 ± 0.85 when the insertion angle of the haptic was 0°, 10°, 27.5°, and 45° in the vertical direction, respectively (p < 0.01). Clinical and experimental IOL tilt assessment using iOCT is interactively useful for better quality surgery and better postoperative outcome.
    Jul. 2023, Scientific reports, 13(1) (1), 12065 - 12065, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Makoto Nakamura, Mari Sakamoto, Kaori Ueda, Mina Okuda, Fumio Takano, Yuko Yamada-Nakanishi
    Patients with asymmetric glaucomatous optic neuropathy (GON) present a relative afferent pupillary defect (RAPD) in the eye with more advanced damage. Although useful, pupillometric RAPD quantification is not widely used as it is not portable. Whether asymmetry of the peripapillary capillary perfusion density (CPD) detected using optical coherence tomography angiography correlates with the severity of RAPD remains unknown. This study assessed RAPD in 81 patients with GON using Hitomiru, a novel hand-held infrared binocular pupillometer. The correlation and ability to detect clinical RAPD based on the swinging flash light test of two independent RAPD parameters (the maximum pupil constriction ratio and the constriction maintenance capacity ratio) were assessed. The coefficient of determination (R2) was calculated between each of the two RAPD parameters and asymmetry of the circumpapillary retinal nerve fiber layer thickness (cpRNFLT), ganglion cell layer/inner plexiform layer thickness (GCL/IPLT), and CPD. The two RAPD parameters showed a correlation coefficient of 0.86 and areas under the receiver operating characteristic (ROC) curve of 0.85-0.88, with R2 being 0.63-0.67 for the visual field, 0.35-0.45 for cpRNFLT, 0.45-0.49 for GCL/IPLT, and 0.53-0.59 for CPD asymmetry. Hitomiru has high discriminatory performance in detecting RAPD in patients with asymmetric GON. CPD asymmetry may better correlate with RAPD than cpRNFLT and GCL/IPLT asymmetry.
    Jun. 2023, Journal of clinical medicine, 12(12) (12), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akari Kimura, Hisanori Imai, Yukako Iwane, Maya Kishimoto, Yasuyuki Sotani, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    The appropriate surgical technique to improve the closure rate of perioperative full-thickness macular hole (FTMH) secondary to submacular hemorrhage (SMH) with sub-internal limiting membrane (ILM) hemorrhage caused by retinal arterial macroaneurysm (RAM) rupture remains an unsolved clinical problem. Several ILM transplantation techniques have been attempted, but these are challenging. Our new technique can remove sub-ILM hemorrhage with the central fovea ILM intact, without peeling the ILM. The medical records of three eyes from three patients with SMH and sub-ILM hemorrhage secondary to RAM rupture were retrospectively reviewed. During the surgery, a small ILM fissure was made outside the central fovea with ILM forceps, and sub-ILM hemorrhage was washed out through it by manually spraying balanced salt solution. Sub-ILM hemorrhage removal was achieved successfully in all eyes, with no occurrences of FTMH or other complications. Best-corrected decimal visual acuity improved from 0.05 (Snellen equivalent (SE), 20/400), 0.05 (SE, 20/400), and 0.05 (SE, 20/400) preoperatively to 0.3 (SE, 20/63), 0.4 (SE, 20/50), and 0.15 (SE, 20/125) at 3 months postoperatively, respectively. This new technique may help keep the foveal ILM intact and prevent perioperative FTMH formation.
    May 2023, Journal of clinical medicine, 12(9) (9), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Rei Sotani, Wataru Matsumiya, Kyung Woo Kim, Akiko Miki, Eriko Yasuda, Yoshifumi Maeda, Rumiko Hara, Sentaro Kusuhara, Makoto Nakamura
    PURPOSE: The aim of this study is to explore the clinical features and associated factors of intraocular inflammation (IOI) following intravitreal brolucizumab (IVBr) administration for neovascular age-related macular degeneration (nAMD). METHODS: This retrospective study included 87 eyes from 87 Japanese patients with nAMD who were followed up for 5 months after the initial administration of IVBr as switching therapy. Clinical pictures of IOI post-IVBr and changes in best corrected visual acuity (BCVA) at 5 months were evaluated between eyes with and without IOI (non-IOI). The association between IOI and baseline factors (age, sex, BCVA, hypertension, and/or arteriosclerotic changes in the fundus, subretinal hyperreflective material [SHRM], and macular atrophy) was evaluated. RESULTS: Of the 87 eyes, 18 (20.6%) developed IOI and 2 (2.3%) developed retinal artery occlusion. There were 9 (50%) cases of posterior or pan-uveitis among eyes with IOI. The mean interval from initial IVBr administration to IOI was 2 months. The mean changes in logMAR BCVA at 5 months were significantly worse in IOI eyes than in non-IOI eyes (0.09 ± 0.22 vs. - 0.01 ± 0.15, P = 0.03). There were 8 (44.4%) and 7 (10.1%) cases of macular atrophy and 11 (61.1%) and 13 (18.8%) cases of SHRM in the IOI and non-IOI groups, respectively. SHRM and macular atrophy were significantly associated with IOI (P = 0.0008 and P = 0.002, respectively). CONCLUSION: In IVBr therapy for nAMD, eyes with SHRM and/or macular atrophy should be observed more meticulously, given the increased risk of developing IOI, which is associated with insufficient BCVA gain.
    Mar. 2023, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 261(8) (8), 2359 - 2366, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Sentaro Kusuhara, Maya Kishimoto-Kishi, Wataru Matsumiya, Akiko Miki, Hisanori Imai, Makoto Nakamura
    Background and Objectives: Faricimab is a novel bispecific antibody with Fab regions inhibiting both vascular endothelial growth factor-A and angiopoietin-2. Therefore, this study aimed to obtain short-term outcomes of intravitreal injection of faricimab (IVF) for the treatment of diabetic macular edema (DME) in daily clinical practice. Materials and Methods: A retrospective review was carried out on consecutive patients with DME who had been treated with IVF and were followed up for at least 1 month. Outcome measures included changes in logMAR best-corrected visual acuity (logMAR BCVA), central retinal thickness (CRT), number of IVF administrations, and safety. Clinical outcomes were also compared between the treatment-naïve and switch groups. Results: A total of 21 consecutive DME eyes from 19 patients were identified. The mean number of IVFs was 1.6 ± 0.8 during the mean follow-up time of 5.5 months. The overall mean logMAR BCVA following IVF was 0.236, 0.204, 0.190, and 0.224 at baseline, 1, 3, and 6 months, respectively, without a significant change from baseline to 1 month (p = 0.176) or for 6 months (p = 0.923). The overall mean CRT (μm) following IVF was 400.6, 346.6, 342.1, and 327.5 at baseline, 1, 3, and 6 months, respectively. CRT significantly decreased from baseline to 1 month (p = 0.001) but did not reach a significant level over 6 months following IVF (p = 0.070). No significant difference in BCVA or CRT was observed between the treatment-naïve and switch groups. No serious safety concerns were noted. Conclusions: IVF for the treatment of DME may preserve visual acuity and improve macular thickness without serious safety concerns in the short term in a real-world clinical setting.
    Mar. 2023, Medicina (Kaunas, Lithuania), 59(4) (4), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • マイクロフックトラベクロトミー(μTLO)の1年後成績への術前緑内障点眼の影響
    昭原 郁仁, 盛 崇太朗, 奥田 実奈, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 218 - 218, Japanese

  • 甲状腺眼症に対するステロイドパルス療法とミニパルス療法の合併症
    高野 史生, 坂本 麻里, 昭原 郁仁, 岸本 真椰, 長井 隆行, 中村 誠
    (公財)日本眼科学会, Mar. 2023, 日本眼科学会雑誌, 127(臨増) (臨増), 246 - 246, Japanese

  • Yoshiaki Kiuchi, Toshihiro Inoue, Nobuyuki Shoji, Makoto Nakamura, Masaki Tanito
    We are pleased to bring you the 5th edition of the Glaucoma Clinical Practice Guidelines. Clinical practice guidelines are based on evidence (scientific grounds). It is a document that presents the treatment that is the most appropriate for the patient. "Glaucoma Clinical Guidelines" was first published in 2003. This was the first guideline for glaucoma treatment in Japan. The principle of glaucoma treatment is to lower intraocular pressure. Means for lowering intraocular pressure includes drugs, lasers, and surgery; Glaucoma is a disease that should be considered as a complex syndrome rather than a single condition. Therefore, the actual medical treatment is not as simple as one word. This time we set the Clinical Questionnaire with a focus on glaucoma treatment. We hope that you will take advantage of the 5th edition.
    Mar. 2023, Japanese journal of ophthalmology, 67(2) (2), 189 - 254, English, Domestic magazine
    [Refereed][Invited]
    Scientific journal

  • Aya Kamimura, Akiko Miki, Maya Kishi, Mina Okuda, Mayuka Hayashida-Hirano, Mari Sakamoto, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    PURPOSE: To compare the two-year outcome of half-time photodynamic therapy (htPDT) in chronic central serous chorioretinopathy (cCSC) with and without choroidal neovascularization (CNV). METHODS: In this retrospective study, we included 88 eyes of 88 patients with cCSC who underwent htPDT and were followed up for more than 24 months. Patients were divided into two groups with (21 eyes) or without (67 eyes) CNV before htPDT treatment. The best-corrected visual acuity (BCVA), central retinal thickness (CRT), subfoveal choroidal thickness (SCT), and the presence of subretinal fluid (SRF) were evaluated at baseline and at 1, 3, 6, 12, and 24 months after PDT. RESULTS: A significant intergroup difference was noted in terms of age (P = 0.038). Significant improvements in the BCVA and SCT were found at all time points in eyes without CNV but only at 24 months in eyes with CNV. CRT was significantly reduced in both groups at all time points. No significant intergroup differences were noted in terms of BCVA, SCT and CRT at all time points. There were significant differences in the rate of recurrent and persistent SRF between groups (22.4% (without CNV) vs. 52.4% (with CNV), P = 0.013, and 26.9% (without CNV) vs. 57.1% (with CNV), P = 0.017, respectively). The presence of CNV was significantly associated with the recurrence and persistence of SRF after initial PDT (P = 0.007 and 0.028, respectively). Logistic regression analyses showed that the baseline BCVA, and not the presence of CNV, was significantly associated with BCVA at 24 months after initial PDT (P < 0.01). CONCLUSIONS: A htPDT for cCSC was less effective in eyes with CNV than in those without CNV regarding the recurrence and persistence of SRF. Additional treatment might be required in eyes with CNV during 24-month follow-up periods.
    2023, PloS one, 18(5) (5), e0284979, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Ritsu Akatani, Norio Chihara, Shusuke Koto, Sotaro Mori, Takuji Kurimoto, Makoto Nakamura, Hisatsugu Tachibana, Yoshihisa Otsuka, Takehiro Ueda, Takashi Omori, Kenji Sekiguchi, Riki Matsumoto
    Dec. 2022
    Link to Kobe Univ. Repository (Kernel)

  • Heads-Up Surgeryにおける無彩色映像下での内境界膜の視認性
    岩根 友佳子, 今井 尚徳, 木村 朱里, 曽谷 育之, 山田 裕子, 三木 明子, 中村 誠
    (公社)日本眼科手術学会, Dec. 2022, 眼科手術, 36(臨増) (臨増), 172 - 172, Japanese

  • Yasuyuki Sotani, Hisanori Imai, Yukako Iwane, Tomohiro Yokogawa, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    PURPOSE: To report the usefulness of a new surgical method using intraoperative optical coherence tomography that can more accurately place the buckling material for scleral buckling using a noncontact wide-angle viewing system with a cannula-based chandelier endoilluminator for the treatment of rhegmatogenous retinal detachment. METHODS: The medical records of 12 eyes of 11 patients with rhegmatogenous retinal detachment treated with scleral buckling combined with real-time intraoperative optical coherence tomography observation were retrospectively reviewed. RESULTS: Real-time observations of the positional relationship between the protrusion of buckling material and retinal breaks with intraoperative optical coherence tomography revealed that retinal breaks were not properly placed on the protrusion of the buckling material in five eyes, requiring the intraoperative repositioning of the buckling material. Eventually, the scleral buckling combined with real-time intraoperative optical coherence tomography observation yielded the initial anatomical success rates of 100% without noteworthy intraoperative or postoperative complications. CONCLUSION: This procedure is a novel approach that enables safer and more accurate placement of the buckling material and may contribute to improving the outcomes of scleral buckling in the future.
    Dec. 2022, Retina (Philadelphia, Pa.), 42(12) (12), 2395 - 2400, English, International magazine
    Scientific journal

  • Fumio Takano, Sotaro Mori, Mina Okuda, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: The purpose of this retrospective study was to determine the extent to which the use of antithrombotic drugs during glaucoma surgery contributes to surgical failure and postsurgical hemorrhagic complications. METHODS: Glaucoma surgeries were categorized into three groups: trabeculotomy (TLO), trabeculectomy (TLE), and long-Tube shunt surgery (Tube). At 1 year after surgery, the following criteria for surgical success were met: intraocular pressure (IOP) in the 5-21-mmHg range, IOP reduction of at least 20% from the preoperative level, and no additional glaucoma surgeries. We compared the percentages of the success rates and hemorrhagic complications between antithrombotic medication experiencers and non-experiencers. Furthermore, we adjusted the preoperative factors between the two groups using a propensity score analysis in TLO and TLE surgeries. RESULTS: A total of 910 glaucoma surgeries were included, with TLO, TLE, and Tube accounting for 353, 444, and 113 surgeries, respectively. Preoperative antithrombotic medications were administered to 149 patients in all glaucoma surgeries: 37 patients used only anticoagulants, 102 used only antiplatelets, and 10 used both. There was no significant difference in the success rates of any of the procedures. The hemorrhagic complications (hyphema and vitreous hemorrhage rate) were significantly higher in the patients who underwent TLE and Tube. The surgical success rates of TLO and TLE were not significantly different after the two groups were matched by propensity score. CONCLUSION: The perioperative use of antithrombotic drugs did not affect success for any of the procedures. However, it increased early postoperative hemorrhagic complications for TLE and Tube.
    Nov. 2022, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 260(11) (11), 3607 - 3615, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 黄斑下出血に対する組織プラスミノーゲン活性化因子併用硝子体内ガス注入の治療成績
    堂脇 雄音, 三木 明子, 奥田 実奈, 岸本 麻椰, 中鉢 亜弥, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2022, 眼科臨床紀要, 15(11) (11), 762 - 763, Japanese

  • 岡山 真由佳, 上田 香織, 千原 典夫, 昭原 郁仁, 奥田 実奈, 高野 史生, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本神経眼科学会, Oct. 2022, 神経眼科, 39(増補1) (増補1), 92 - 92, Japanese

  • ブロルシズマブ硝子体内注射後の眼内炎症の頻度と特徴
    楠原 仙太郎, 三木 明子, 岸本 真椰, 中村 誠
    眼科臨床紀要会, Oct. 2022, 眼科臨床紀要, 15(10) (10), 688 - 688, Japanese

  • 線維柱帯切除術後の早期濾過胞機能不全に対するマイトマイシンC併用濾過胞再建術の術後3年成績
    増田 理沙, 坂本 麻里, 昭原 郁仁, 奥田 実奈, 高野 史生, 盛 崇太朗, 上田 香織, 栗本 拓治, 金森 章泰, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 101 - 101, Japanese

  • 当院で経験した虹彩分離症5症例の臨床的特徴
    昭原 郁仁, 上田 香織, 奥田 実奈, 高野 史生, 盛 崇太朗, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 146 - 146, Japanese

  • マイクロフックトラベクロトミー(μTLO)の術成績に対する術前リパスジル点眼投与の影響
    奥田 実奈, 盛 崇太朗, 昭原 郁仁, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2022, 日本緑内障学会抄録集, 33回, 154 - 154, Japanese

  • Mina Okuda, Sotaro Mori, Fumio Takano, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: This study examined the perioperative factors affecting surgical success in ab interno microhook trabeculotomy (μTLO). METHODS: A total of 146 consecutive patients who underwent μTLO were included in this retrospective study. We performed Cox proportional hazard modelling by setting surgical success at 1 year as an objective variable. The explanatory variables included age, sex, glaucoma type, preoperative intraocular pressure (IOP), glaucoma drug score, mean deviation (MD) of the Humphrey visual field test, duration of glaucoma drug use, antithrombotic drug use, combined cataract surgery, incision range and diabetes mellitus. Additionally, we performed 1:1 matching using propensity score analysis and compared the perioperative parameters between durations of glaucoma drug use of <4.5 years and ≥ 4.5 years (50 patients each). We defined surgical success as satisfaction of all three criteria: IOP 5-21 mmHg, IOP reduction of ≥20% from the preoperative IOP and no additional glaucoma surgery. RESULTS: The Cox proportional hazard model revealed that a longer duration of anti-glaucoma medication was significantly associated with surgical failure. Propensity score matching analysis showed that the <4.5-year users of anti-glaucoma drugs had significantly higher success rates than the ≥4.5-year users (72% versus 52%; p = 0.04). CONCLUSIONS: The prolonged use of multiple glaucoma drugs adversely affected the outcome of μTLO at least at 1 year postoperatively.
    Sep. 2022, Acta ophthalmologica, 100(6) (6), e1209-e1215, English, International magazine
    Scientific journal

  • Mari Sakamoto, Hiromasa Sawamura, Makoto Aihara, Toshiaki Goseki, Tetsuya Ikeda, Hitoshi Ishikawa, Makoto Nakamura
    PURPOSE: To compare the ability of imo binocular random single-eye test (BRSET) to detect visual field (VF) defects due to chiasmal and postchiasmal lesions (C/PCLs) with a Humphrey Field Analyzer (HFA) monocular test. STUDY DESIGN: Prospective multicenter study METHODS: This study enrolled 40 patients with C/PCLs and measured their VFs using both imo BRSET and HFA monocular test. The VFs were classified into three groups using the cluster criterion: 1) bitemporal group, 2) homonymous group, and 3) others. The agreement and correlation of VF results between imo and HFA were analyzed using the Bland-Altman plot and Spearman correlation coefficient. RESULTS: The VFs of 34 patients were analyzed and classified. There were 13 patients in the bitemporal, 6 in the homonymous, and 15 in the others group. BRSET showed a significantly shorter test duration than HFA. The imo systematically yielded a lower sensitivity than HFA. The average sensitivity at each test location correlated well between the perimeters in all groups, with the correlation coefficients ranging from 0.89 to 0.98. Bland-Altman plots showed wider limits of agreement in the affected quadrants compared to the unaffected quadrants in the bitemporal and homonymous groups. The fixation loss rate did not differ between the perimeters, but there were significant differences in the false positive and false negative rates between perimeters. CONCLUSION: BRSET detected VF defects due to C/PCLs as accurately as the HFA monocular test with a shorter test duration.
    Sep. 2022, Japanese journal of ophthalmology, 66(5) (5), 413 - 424, English, Domestic magazine
    Scientific journal

  • Yuki Mori, Masahiro Miyake, Yoshikatsu Hosoda, Akiko Miki, Ayako Takahashi, Yuki Muraoka, Manabu Miyata, Takehiro Sato, Hiroshi Tamura, Sotaro Ooto, Ryo Yamada, Kenji Yamashiro, Makoto Nakamura, Atsushi Tajima, Masao Nagasaki, Shigeru Honda, Akitaka Tsujikawa
    PURPOSE: To identify susceptibility genes for macular neovascularization (MNV) development in central serous chorioretinopathy (CSC). DESIGN: Genome-wide survival analysis using a longitudinal cohort study. PARTICIPANTS: We included 402 and 137 patients with CSC but without MNV at their first visit from the Kyoto CSC Cohort and Kobe CSC dataset, respectively. All patients underwent detailed ophthalmologic examinations, including multimodal imaging, such as fundus autofluorescence, spectral-domain optical coherence tomography, and fluorescein angiography/indocyanine green angiography and/or optimal coherence tomography angiography. METHODS: We conducted a genome-wide survival analysis using the Kyoto CSC Cohort. We applied the Cox proportional hazard model to adjust for age, sex, and the first principal component. Single nucleotide polymorphisms (SNPs) with P-values <1.0×10-5 were carried forward to the replication in the Kobe CSC dataset. Moreover, we evaluated the contribution of previously-reported age-related macular degeneration (AMD) susceptibility loci. We used FUMA and ToppFun for the functional enrichment analysis. MAIN OUTCOME MEASURES: The association between SNPs and MNV development in patients with CSC. RESULTS: Rs370974631 near ARMS2 displayed a genome-wide significant association in the meta-analysis of discovery and replication result (hazard ratio [HR]meta = 3.63; Pmeta = 5.76×10-9). Among previously-reported AMD susceptibility loci, we additionally identified CFH rs800292 (HR = 0.39, P = 2.55×10-4), COL4A3 rs4276018 (HR = 0.26, P = 1.56×10-3), and B3GALTL rs9564692 (HR = 0.56, P = 8.30×10-3) as susceptibility loci for MNV development in CSC. The functional enrichment analysis revealed significant enrichment of eight pathways (GO:0051561, GO:0036444, GO:0008282, GO:1990246, GO:0015272, GO:0030955, GO:0031420, and GO:0005242) related to ion transport. CONCLUSIONS: ARMS2, CFH, COL4A3, and B3GALTL were identified as susceptibility genes for MNV development in CSC. The aforementioned four genes are known as susceptibility genes for AMD, whereas COL4A3 and B3GALTL were previously reported to be polypoidal choroidal vasculopathy (PCV)-specific susceptibility genes. Our findings revealed the shared genetic susceptibility between PCV and MNV secondary to CSC.
    Sep. 2022, Ophthalmology, 129(9) (9), 1034 - 1042, English, International magazine
    [Refereed]
    Scientific journal

  • ラニビズマブの硝子体内注射による未熟児網膜症の治療効果
    高野 史生, 上田 香織, 三木 明子, 今井 尚徳, 中西 裕子, 中村 誠
    眼科臨床紀要会, Jun. 2022, 眼科臨床紀要, 15(6) (6), 418 - 418, Japanese

  • Sentaro Kusuhara, Kyung Woo Kim, Akiko Miki, Makoto Nakamura
    PURPOSE: To describe angiographic features of a case of delayed-onset retinal vascular occlusion and intraocular inflammation (IOI) following brolucizumab intravitreal injection (IVI). OBSERVATIONS: A 75-year-old woman with advanced age-related macular degeneration (AMD) complained of persistent distorted vision despite 1 aflibercept 2-mg IVI and subsequent 1 brolucizumab 6-mg IVI. At 20 days after brolucizumab IVI, clinical examination showed no signs of IOI, her right best-corrected visual acuity (BCVA) was 1.0 (Snellen equivalent, 20/20). Simultaneous fluorescein and indocyanine green angiography (FA/IA) performed 2 days later showed no abnormalities, but she noticed floaters and decreased vision in her right eye 5-6 hours after FA/IA. At 44 days after brolucizumab IVI, her right BCVA was 0.6 (Snellen equivalent, 20/33), and clinical examination revealed mutton-fat keratic precipitates, anterior chamber cells (2+), vitreous cells, vitreous haze (1+), and sheathed retinal vessels. FA showed filling defect and vascular staining/leakage at several retinal arteries and dye leakage from optic disc edge, where IA demonstrated dye staining as well. However, there was a retinal artery occlusion site which lacks angiographic signs indicative of active retinal vasculitis. The patient was diagnosed with retinal vascular occlusion and IOI which occurred approximately 3 weeks after brolucizumab IVI. CONCLUSIONS AND IMPORTANCE: Delayed brolucizumab-associated retinal vascular occlusion and IOI can develop from a condition in which no apparent abnormal findings exist on FA/IA. Together with the fact that angiographic signs observed in this case were not severe enough to induce retinal artery occlusion, potent and prolonged vascular endothelial growth factor inhibition by brolucizumab IVI might have caused severe damage to retinal vascular endothelial cells. Then, the damage subsequently led to retinal vascular occlusions and enhanced immune reaction to brolucizumab. The latter would be enhanced through the migration of immune cells towards vitreous cavity being allowed by disrupted inner blood retinal barrier.
    Jun. 2022, American journal of ophthalmology case reports, 26, 101521 - 101521, English, International magazine
    Link to Kobe Univ. Repository (Kernel)

  • 【どう診る?視野異常】神経眼科疾患と視野
    坂本 麻里, 中村 誠
    (株)全日本病院出版会, May 2022, OCULISTA, (110) (110), 43 - 48, Japanese

  • 緑内障患者におけるアイモ両眼ランダム測定の再現性の検討
    豊国 秀昭, 坂本 麻里, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 172 - 172, Japanese

  • 加齢黄斑変性に対するブロルシズマブ投与後の眼内炎症の臨床像と関連事前因子の検討
    曽谷 令, 松宮 亘, 岸本 真椰, 三木 明子, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 213 - 213, Japanese

  • 脈絡膜新生血管の有無による慢性中心性脈絡網膜症患者における治療成績
    中鉢 亜弥, 三木 明子, 岸本 真椰, 島内 深希, 和田 友紀, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 274 - 274, Japanese

  • 滲出型加齢黄斑変性に対するブロルシズマブへの切り替え効果についての検討
    岸本 真椰, 三木 明子, 中鉢 亜弥, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠, 原 ルミ子
    (公財)日本眼科学会, Mar. 2022, 日本眼科学会雑誌, 126(臨増) (臨増), 276 - 276, Japanese

  • Daiki Sakai, Wataru Matsumiya, Sentaro Kusuhara, Makoto Nakamura
    Springer Science and Business Media Deutschland GmbH, Dec. 2021, Journal of Ophthalmic Inflammation and Infection, 11(1) (1), English
    Scientific journal

  • Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: We compared the 1-year outcomes and early surgery-related complications between 1-quadrant and 2-quadrant microhook ab interno trabeculotomy (TLO). METHODS: Medical chart extraction was performed on 47 consecutive patients with 1-quadrant incision and 37 consecutive patients with 2-quadrant incision of trabecular meshwork. Logistic regression analysis was conducted to calculate the propensity score to create a 1:1 match for a comparative analysis of 1-year postoperative success. Success was defined as postoperative intraocular pressure (IOP) between 5-21 mmHg, >20% IOP reduction from baseline, and no additional glaucoma surgery. Outcome-related covariates were age, glaucoma type, mean deviation of visual field tests, preoperative IOP, the number of preoperative glaucoma eye drops and the presence of combined cataract surgery. Thirty eyes from each group were compared. RESULTS: The median preoperative IOP was not different between the 1-quadrant and 2-quadrant groups (28.5 mmHg, quartile range 23-33.5 versus 27 mmHg, 23.3-30.0, p = 0.47). There was no difference in median postoperative IOP at 1 year (15 mmHg versus 16 mmHg, p = 0.80). The success rate was 73% in the 1-quadrant group versus 70% in the 2-quadrant group (p = 1.00). The 2-quadrant group had a significantly higher proportion of patients with transiently elevated IOP (47%) than the 1-quadrant (17%; Fisher's exact test, p = 0.02). There was no difference of hyphema formation (Fisher's exact test, p = 0.18). CONCLUSION: The 1-year success rate was not significantly different between 1- and 2-quadrant incisions of microhook TLO. However, the 2-quadrant TLO showed significantly higher proportion of post-surgical transient IOP elevation.
    Dec. 2021, Acta ophthalmologica, 99(8) (8), 898 - 903, English, International magazine
    Scientific journal

  • Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: The purpose of this study was to evaluate the 3-year surgical outcome of the sulcus fixation of Baerveldt glaucoma implant (BGI), focusing on corneal damage. METHODS: This prospective observational study included 37 patients who underwent a median of two previous glaucoma surgeries and sulcus fixation of BGI for the first time. Each patient's intraocular pressure (IOP), glaucoma drug score, corneal endothelial cell density (ECD), and logMAR-converted best-corrected visual acuity (VA) were measured preoperatively and postoperatively until 36 months after surgery. Complete success was defined as reduced IOP (5-21 mmHg and >20% rate), without corneal damage (postoperative development of decompensation, unmeasurable ECD, or reduction in ECD of >20%), without loss of light perception, and without additional surgery requirement. Qualified success was defined by excluding the corneal criteria from complete success. RESULTS: A total of 51% (19/37) patients experienced complete treatment success, whereas 86% (32/37) had qualified success. The median IOP (glaucoma drug score) decreased from 26 mmHg (5) to 15 mmHg (2) at three years postoperatively. The median postoperative ECD (reduction rate) decreased from 1838 cells/cm2 preoperatively to 1587 cells/mm2 (14%) at one year, 1358 cells/mm2 (26%) at two years, and 1228 cells/mm2 (33%) at three years postoperatively. One month after surgery, the VA was significantly reduced from preoperative values but did not decline after that. CONCLUSION: Sulcus fixation of BGI was effective for IOP reduction. However, ECD decreased over time.
    Dec. 2021, Acta ophthalmologica, 99(8) (8), e1435-e1441, English, International magazine
    Scientific journal

  • Akio Oishi, Kaoru Fujinami, Go Mawatari, Nobuhisa Naoi, Yasuhiro Ikeda, Shinji Ueno, Kazuki Kuniyoshi, Takaaki Hayashi, Hiroyuki Kondo, Atsushi Mizota, Kei Shinoda, Sentaro Kusuhara, Makoto Nakamura, Takeshi Iwata, Akitaka Tsujikawa, Kazushige Tsunoda
    Peripherin-2 (PRPH2) is one of the causative genes of inherited retinal dystrophy. While the gene is relatively common in Caucasians, reports from Asian ethnicities are limited. In the present study, we report 40 Japanese patients from 30 families with PRPH2-associated retinal dystrophy. We identified 17 distinct pathogenic or likely pathogenic variants using next-generation sequencing. Variants p.R142W and p.V200E were relatively common in the cohort. The age of onset was generally in the 40's; however, some patients had earlier onset (age: 5 years). Visual acuity of the patients ranged from hand motion to 1.5 (Snellen equivalent 20/13). The patients showed variable phenotypes such as retinitis pigmentosa, cone-rod dystrophy, and macular dystrophy. Additionally, intrafamilial phenotypic variability was observed. Choroidal neovascularization was observed in three eyes of two patients with retinitis pigmentosa. The results demonstrate the genotypic and phenotypic variations of the disease in the Asian cohort.
    Nov. 2021, Genes, 12(11) (11), English, International magazine
    Scientific journal

  • Yusuke Murai, Sotaro Mori, Fumio Takano, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura
    PURPOSE: Cytomegalovirus (CMV)-related keratouveitis elevates intraocular pressure (IOP). Antiviral therapy does not always control IOP and some patients do not tolerate systemic antiviral therapy because of the side effects. The purpose of this study is to evaluate the clinical characteristics of patients with CMV-related keratouveitis and determine the impact of glaucoma surgeries on the postoperative antiviral therapy regimen. METHODS: We enrolled twenty-two patients with CMV-DNA-positive keratouveitis between June 2012 and July 2019 in Kobe University Hospital. The following clinical parameters were collected: gender, age, history of previous intraocular surgery, antiviral medications, visual acuity, IOP, glaucoma drug score, corneal endothelial cells density, and the mean deviation of a Humphrey visual field test at the first visit and before and 1 year after glaucoma surgery. RESULTS: All twenty-two patients started on oral and/or topical antiviral therapy. Eighteen patients needed glaucoma surgery despite their antiviral medications. Nine patients underwent trabeculotomy (TLO) and nine underwent trabeculectomy (TLE) as the first surgical intervention. Six of patients who initially underwent TLO and two of the patients who initially underwent TLE required additional TLE within 1 year. Each of the 15 patients who underwent at least 1 TLE showed a reduction in the magnitude and variation of IOP and glaucoma drug scores and 13 patients were able to discontinue antiviral therapy. For the remaining 4 patients, IOP and inflammation were controlled but with antiviral medications. CONCLUSIONS: In patients with CMV-related keratouveitis, TLE decreases and stabilizes IOP and contributes to withdrawal from antiviral medications.
    Nov. 2021, BMC ophthalmology, 21(1) (1), 389 - 389, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 昭原 郁仁, 上田 香織, 栗本 拓治, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2021, 神経眼科, 38(増補1) (増補1), 72 - 72, Japanese

  • 越智 博隆, 栗本 拓治, 奥田 実奈, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2021, 神経眼科, 38(増補1) (増補1), 87 - 87, Japanese

  • 黄斑部毛細血管拡張に伴う嚢胞様黄斑浮腫に嚢胞様腔内壁切開術が奏効した1例
    牧 仁美, 今井 尚徳, 山田 裕子, 鉄本 章, 林田 真由香, 大塚 慶子, 三木 明子, 中村 誠
    眼科臨床紀要会, Nov. 2021, 眼科臨床紀要, 14(11) (11), 757 - 757, Japanese

  • 中心性漿液性脈絡網膜症患者における半量エネルギー光線力学的療法後低コントラスト視力
    中鉢 亜弥, 三木 明子, 林田 真由香, 島内 深希, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    眼科臨床紀要会, Nov. 2021, 眼科臨床紀要, 14(11) (11), 758 - 759, Japanese

  • Kyung Woo Kim, Sentaro Kusuhara, Hisanori Imai, Noriyuki Sotani, Ryuto Nishisho, Wataru Matsumiya, Makoto Nakamura
    Frontiers Media S.A., Oct. 2021, Frontiers in Medicine, 8, English
    Scientific journal

  • Kaori Ueda, Takuji Kurimoto, Fumio Takano, Yusuke Murai, Sotaro Mori, Mari Sakamoto, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura
    INTRODUCTION: Leber hereditary optic neuropathy (LHON) is an acute or subacute inherited optic neuropathy caused by mitochondrial mutations. More than 90% of patients with LHON have one of three point mutations (ie, G3460A, G11778A and T14484C). We previously reported that a 12-week session of skin electrical stimulation (SES) with a 2-week interval significantly improved visual acuity and field tests 1 week after the last stimulation and without adverse effects in 10 cases of LHON carrying the mt DNA G11778A mutation. In the present study, we will examine the magnitude and persistence of the efficacy and presence or absence of adverse events using SES with a more frequent stimulation protocol. METHODS AND ANALYSIS: This study will be a single-arm, open-labelled, non-randomised clinical study that analyses 15 cases of LHON with G11778A mutation. All participants will take a portable SES device home and perform SES by themselves every other day for 12 weeks. The logarithm for the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) at 1 week after the last SES will be measured as the primary outcome. LogMAR BCVA will be measured at four and 8 weeks after the last SES treatment. The Humphrey visual field sensitivity test using size V stimulation and critical fusion frequency at 1, 4 and 8 weeks after the last SES session will be secondary outcome measurements. Slit-lamp examination, optical coherence tomography and specular microscopy will also be performed to verify the safety of SES. ETHICS AND DISSEMINATION: The protocol was approved by the Institutional Review Board at Kobe University, Japan (Approval No.C190030). This study is in progress and deserves Pre-result. All documents communicating with the ethics committee will be reposited by the researcher. Modifications to the protocol will be reviewed by the ethics committee and implemented after approval. Data monitoring will be performed by a researcher who is not involved in the study every 6 months after approval. The research summary results will be registered in the Japan Registry of Clinical Trials (jRCTs) and made available to participants in accordance with the terms described in the documents. In addition, the results of this study will be presented at domestic and international meetings and published in peer-reviewed journals within a year after data is fixed. TRIAL REGISTRATION NUMBER: jRCTs052200033.
    Oct. 2021, BMJ open, 11(10) (10), e048814, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 裂孔原性網膜剥離に対する硝子体手術後の歪視量に寄与する周術期因子の検討
    山田 裕子, 今井 尚徳, 鉄本 章, 林田 真由香, 大塚 慶子, 三木 明子, 中村 誠
    眼科臨床紀要会, Oct. 2021, 眼科臨床紀要, 14(10) (10), 684 - 685, Japanese

  • 標準治療からの逸脱が糖尿病黄斑浮腫の治療効果に及ぼす影響
    西庄 龍東, 楠原 仙太郎, 曽谷 尭之, 金 景佑, 三木 明子, 今井 尚徳, 中村 誠
    眼科臨床紀要会, Oct. 2021, 眼科臨床紀要, 14(10) (10), 690 - 691, Japanese

  • 抗MOG抗体関連疾患における画像上のくすぶり病変の意義
    刀坂 公崇, 千原 典夫, 栗本 拓治, 十河 正弥, 上田 健博, 関口 兼司, 中村 誠, 松本 理器
    (一社)日本神経免疫学会, Oct. 2021, 神経免疫学, 26(1) (1), 132 - 132, Japanese

  • 抗MOG抗体関連疾患における画像上のくすぶり病変の意義
    刀坂 公崇, 千原 典夫, 栗本 拓治, 十河 正弥, 上田 健博, 関口 兼司, 中村 誠, 松本 理器
    (一社)日本神経免疫学会, Oct. 2021, 神経免疫学, 26(1) (1), 132 - 132, Japanese

  • ロングチューブシャント術後の被膜除去術の短期成績
    奥田 実奈, 盛 崇太朗, 高野 史生, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2021, 日本緑内障学会抄録集, 32回, 136 - 136, Japanese

  • 糖尿病黄斑浮腫におけるen face slab OCT imagingと長期視力予後
    楠原 仙太郎, 西庄 龍東, 三木 明子, 今井 尚徳, 中村 誠
    (一社)日本糖尿病合併症学会, Sep. 2021, 糖尿病合併症, 35(Suppl.1) (Suppl.1), 252 - 252, Japanese

  • 抗MOG抗体関連疾患におけるくすぶり病変は疾患活動性を反映する
    刀坂 公崇, 千原 典夫, 栗本 拓治, 十河 正弥, 関谷 博顕, 上田 健博, 関口 兼司, 中村 誠, 松本 理器
    (一社)日本神経学会, Sep. 2021, 臨床神経学, 61(Suppl.) (Suppl.), S259 - S259, Japanese

  • 視神経挫滅後のアクアポリン9ノックアウトマウスにおける網膜神経節細胞の機能低下と乳酸輸送障害の関係
    盛 崇太朗, 栗本 拓治, 三木 明子, 前田 秀高, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Jul. 2021, 眼科臨床紀要, 14(7) (7), 452 - 452, Japanese

  • Daiki Sakai, Hisanori Imai, Makoto Nakamura
    S. Karger AG, Jun. 2021, Case Reports in Ophthalmology, 12(2) (2), 485 - 491, English
    Scientific journal

  • Kyung Woo Kim, Sentaro Kusuhara, Motoko Tachihara, Chihiro Mimura, Wataru Matsumiya, Makoto Nakamura
    Elsevier Inc., Jun. 2021, American Journal of Ophthalmology Case Reports, 22, English
    Scientific journal

  • 林 由紀子, 坂本 麻里, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, May 2021, 日本眼科学会雑誌, 125(5) (5), 530 - 538, Japanese

  • Ryuto Nishisho, Sentaro Kusuhara, Noriyuki Sotani, Kyong Woo Kim, Atsuko Katsuyama-Yoshikawa, Wataru Matsumiya, Kengo Akashi, Akio Morinobu, Makoto Nakamura
    PURPOSE: To evaluate the short-term change in choroidal structure following adalimumab (ADA) treatment in refractory noninfectious uveitis. METHODS: This was a retrospective study of 33 eyes from 18 patients with refractory noninfectious uveitis. Subfoveal choroidal thickness (SFCT), the choroidal stromal index (CSI) defined as the proportion of stromal area to the total choroidal area were used as choroidal imaging parameters and were evaluated by enhanced depth imaging optical coherence tomography (EDI-OCT). The change in these parameters in the 2 months following initiation of ADA was analysed. A linear mixed-effect model was used to assess the effect of ADA treatment. RESULTS: The causes of uveitis were Vogt-Koyanagi-Harada disease (VKHD) (42.4%), presumed autoimmune retinopathy (15.2%), others (12.1%) and unclassified (30.3%). In the analysis of all eyes, the SFCT was 309.7 ± 113.1 μm at baseline, 295.7 ± 114.5 μm at 1 month and 275.2 ± 98.8 μm at 2 months after ADA initiation (P < 0.001). The CSI was 0.275 ± 0.050 at baseline, 0.273 ± 0.068 at 1 month and 0.273 ± 0.046 at 2 months (P = 0.785). In the subgroup analysis, the SFCT decreased significantly from baseline to 2 months in VKHD eyes (P = 0.007) and unclassified eyes (P = 0.034). There was no significant change in CSI in either subgroup. CONCLUSIONS: In the assessment of short-term response to ADA treatment in uveitic eyes, using EDI-OCT, the SFCT appears to be more effective as a choroidal imaging biomarker than the CSI, especially in VKHD eyes.
    May 2021, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 259(5) (5), 1273 - 1280, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hiroko Yamada, Hisanori Imai, Akira Tetsumoto, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    To demonstrate the long-term effect of cystotomy with or without fibrinogen clot removal for treatment-resistant cystoid macular edema (CME) secondary to branch retinal vein occlusion (BRVO). Retrospective clinical study. We retrospectively analyzed medical records of 22 eyes of 22 patients with treatment-resistant CME secondary to BRVO with 12 months observation after cystotomy with or without fibrinogen clot removal. Patients included 11 women and 11 men. The mean ± SD age was 72.7 ± 10.2 years. LogMAR-converted best corrected visual acuity (BCVA) was statistically better at 12 months after surgery (0.30 ± 0.30) than preoperative BCVA (0.39 ± 0.27) (p = 0.01). The central sensitivity of microperimetry (dB) was maintained during follow-up (preoperative sensitivity: 25.4 ± 4.1, postoperative sensitivity at 12 months after the surgery: 25.9 ± 4.2, p = 0.69). Twelve months after surgery, there was a significant improvement in the central retinal thickness (CRT) on optical coherence tomography (OCT) (303.7 ± 80.1) (μm) compared with the preoperative CRT (524.2 ± 114.8) (p < 0.01). In 12 months, CME recurred in 3 of 22 eyes. The preoperative reflectivity in cystoid cavity on OCT was significantly higher in patients with fibrinogen clot removal (n = 5) than in patients without fibrinogen clot removal (n = 17) (p < 0.01). For treatment-resistant CME secondary to BRVO, Cystotomy with or without fibrinogen clot removal may be one of the treatment options.
    Apr. 2021, Scientific reports, 11(1) (1), 8460 - 8460, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hitomi Maki, Sotaro Mori, Hisanori Imai, Hiroko Yamada, Keiko Otsuka, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    Specific postoperative complications, such as tube exposure and conjunctival erosion, have occurred despite the favorable surgical outcomes of tube shunt surgeries for refractory glaucoma. The new autologous scleral pocket technique is performed by inserting the tube into the vitreous cavity without using a donor scleral patch. The purpose of this study was to evaluate the surgical results of Ahmed glaucoma valve (AGV) implantation using this technique for neovascular glaucoma (NVG), which is one of the representative refractory types of glaucoma. This observational retrospective case series included 15 consecutive eyes of 15 patients with NVG who had undergone AGV implantation at Kobe University between January 2018 and December 2019. The mean preoperative intraocular pressure (IOP) was 37.2 ± 13.8 mmHg and the glaucoma drug score was 4.2 ± 2.2. The mean IOP and glaucoma drug score at 1 year postoperatively decreased to 15.0 ± 4.6 mmHg and 1.3 ± 2.0, respectively (p < 0.001). No significant change in the corneal endothelial cell density following surgery was observed (p = 0.09); however, one patient required an additional trabeculectomy at 7 months postoperatively. No cases of tube exposure or conjunctival erosion were observed at 1 year postoperatively. These results indicated the effectiveness and safety of this technique in patients with NVG.
    Apr. 2021, Journal of clinical medicine, 10(8) (8), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Aya Chubachi, Akiko Miki, Mayuka Hayashida, Mari Sakamoto, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    This retrospective study was conducted to investigate the clinical factors associated with low-contrast visual acuity after reduced-fluence photodynamic therapy (RFPDT) in patients with resolved central serous chorioretinopathy (CSC) and good baseline visual acuity. A total of 45 eyes of 45 patients with resolved CSC at post-RFPDT and best-corrected visual acuity of >1.0 (logarithm of the minimal angle of resolution [logMAR], 0) at baseline were examined. Visual acuities of both eyes were measured at four contrast levels (100%, 25%, 12%, and 6%) at post-RFPDT. The low-contrast visual acuity (6%, 12%, and 25%) was significantly lower than the 100% contrast visual acuity in the affected eyes. Visual acuities of affected eyes were significantly worse than those of fellow eyes at any contrast levels. The degree of changes in 6% and 100% contrast visual acuities was significantly greater in affected eyes than that in fellow eyes (p < 0.05). The 6% contrast visual acuities in affected eyes at post-RFPDT were significantly associated with the symptom duration (p < 0.05). Patients with a long duration of symptoms might have disturbed low-contrast visual acuities at post-RFPDT even if their baseline visual acuities were good.
    Mar. 2021, Pharmaceuticals (Basel, Switzerland), 14(4) (4), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kyung Woo Kim, Sentaro Kusuhara, Atsuko Katsuyama-Yoshikawa, Sho Nobuyoshi, Megumi Kitamura, Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Makoto Nakamura
    Multidrug resistance protein 4 (MRP4) is an energy-dependent membrane transporter responsible for cellular efflux of a broad range of xenobiotics and physiological substrates. In this trial, we aimed to investigate the coeffects of aging and MRP4 deficiency using gene expression microarray and morphological and electrophysiological analyses of mouse retinas. Mrp4-knockout (null) mice and wild-type (WT) mice were reared in the same conditions to 8-12 weeks (young) or 45-55 weeks (aged). Microarray analysis identified 186 differently expressed genes from the retinas of aged Mrp4-null mice as compared to aged WT mice, and subsequent gene ontology and KEGG pathway analyses showed that differently expressed genes were related to lens, eye development, vision and transcellular barrier functions that are involved in metabolic pathways or viral infection pathways. No significant change in thickness was observed for each retinal layer among young/aged WT mice and young/aged Mrp4-null mice. Moreover, immunohistochemical analyses of retinal cell type did not exhibit an overt change in the cellular morphology or distribution among the four age/genotype groups, and the electroretinogram responses showed no significant differences in the amplitude or the latency between aged WT mice and aged Mrp4-null mice. Aging would be an insufficient stress to cause some damage to the retina in the presence of MRP4 deficiency.
    Mar. 2021, Antioxidants (Basel, Switzerland), 10(3) (3), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • マイクロフックトラベクロトミーの緑内障点眼歴による術後成績の比較
    奥田 実奈, 盛 崇太郎, 高野 史生, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2021, 日本眼科学会雑誌, 125(臨増) (臨増), 237 - 237, Japanese

  • 傾向スコア解析による血栓予防薬の有無に対する緑内障手術の術成功と出血合併症頻度
    高野 史生, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2021, 日本眼科学会雑誌, 125(臨増) (臨増), 240 - 240, Japanese

  • Hitomi Maki, Hisanori Imai, Hiroko Yamada, Akira Tetsumoto, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Makoto Nakamura
    PURPOSE: To report the case of a patient with cystoid macular edema (CME) secondary to idiopathic macular telangiectasia (MacTel) type 1, which was successfully treated by cystotomy and en bloc removal of the fibrinogen-rich component of the cystoid lesion. PATIENTS: A 80-year-old man was referred to our department because of a visual defect in his right eye. His best corrected decimal visual acuity (BCVA) was 0.7 (Snellen equivalent [SE], 20/30). METHODS: A fundus examination revealed clustered temporal juxafoveal microaneurysms and foveal CME. The patient refused to undergo conventional treatments, including direct retinal photocoagulation for microaneurysms, intravitreal anti-vascular endothelial growth factor injection, and intravitreal triamcinolone injection. However, he provided consent to undergo cystotomy and en bloc removal of the fibrinogen-rich component of the cystoid lesion. RESULTS: His BCVA was 0.2 (SE, 20/100) just before the surgery. A 27-gauge vitrectomy with internal limiting membrane peeling was performed. Cystotomy was performed during the surgery, and the fibrinogen clot visible in the cystoid cavity was also removed. CME rapidly disappeared after the surgery. Three years postoperatively, the patient had BCVA of 0.5 (SE, 20/40) at the last medical examination, and the CME had not recurred. CONCLUSION: Cystotomy and en bloc removal of the fibrinogen-rich component of the cystoid lesion could be valid treatment options for CME secondary to MacTel type 1.
    Jan. 2021, Retinal cases & brief reports, Publish Ahead of Print, English, International magazine
    Scientific journal

  • Yusuke Murai, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Mari Sakamoto, Kengo Akashi, Yuko Yamada-Nakanishi, Makoto Nakamura
    We report a rare case of granulomatosis with polyangiitis (GPA) presenting with bilateral orbital apex syndrome (OAS). A 73-year-old woman with a history of endoscopic sinus surgery for ethmoidal sinusitis experienced a sudden decrease in visual acuity (VA) of both eyes. At the initial examination, her VA had decreased to 0.01 in the right eye and 0.03 in the left eye, and eye movement in both eyes was mildly limited in all directions. Visual field tests of both eyes showed a large central scotoma. Laboratory tests revealed an elevation of myeloperoxidase-anti-neutrophil cytoplasmic antibody. Facial computed tomography demonstrated a thickened mucosal membrane in the entire ethmoidal sinus, and the posterosuperior walls of Onodi cells filled with infiltrative lesions had thinned. Orbital magnetic resonance imaging showed severe inflammation in the orbital apex. From these clinical findings, the patient was diagnosed with GPA presenting with OAS associated with ethmoid sinusitis. Emergent endoscopic sinus surgery was performed for biopsy and debridement of the ethmoidal and sphenoid sinusitis to decompress the optic nerve. One day after endoscopic sinus surgery, the patient's VA and visual field were improved, and steroid pulse therapy was commenced postoperatively. Four days later, VA had recovered to 1.0 in both eyes, and eye movement and visual field had were improved. Although OAS is a rare manifestation, early surgical treatment should be considered when the orbital lesion presents as risk of rapid deterioration of visual function in patients with GPA.
    2021, Case reports in ophthalmology, 12(1) (1), 32 - 40, English, International magazine
    Link to Kobe Univ. Repository (Kernel)

  • Hiroko Yamada, Hisanori Imai, Akira Tetsumoto, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Makoto Nakamura
    PURPOSE: To investigate clinical factors contributing to metamorphopsia after 27-gauge pars plana vitrectomy (27GPPV) for primary rhegmatogenous retinal detachment (RRD) to reveal whether the proximity of the preoperative retinal detachment to the fovea is associated with postoperative metamorphopsia. METHODS: We retrospectively reviewed medical records of 77 eyes of 77 patients after 27GPPV for RRD. Patients were subdivided into three groups using optical coherence tomography findings: Group A, patients with RRD outside the vascular arcade; Group B, patients whose condition was present within the vascular arcade, but without foveal detachment; and Group C, patients with foveal detachment. RESULTS: The average metamorphopsia score (°) assessed with M-charts 12 months after surgery was 0.01 ± 0.04 in Group A (24 eyes), 0.08 ± 0.18 in Group B (20 eyes), and 0.49 ± 0.48 in Group C (33 eyes) (p<0.001). Logistic regression analysis revealed that metamorphopsia at 12 months after surgery significantly correlated with the proximity of the retinal detachment to the fovea (p = 0.007). CONCLUSION: Metamorphopsia after 27GPPV for RRD correlated with the proximity of the preoperative retinal detachment to the fovea. Attention should be paid to the possibility of postoperative metamorphopsia development when retinal detachment is present within a vascular arcade even if the fovea is not involved.
    2021, PloS one, 16(10) (10), e0258775, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Osamu Mimura, Hitoshi Ishikawa, Takeshi Kezuka, Keigo Shikishima, Tone Suzuki, Makoto Nakamura, Hideki Chuman, Kenji Inoue, Akiko Kimura, Akiko Yamagami, Maki Mihoya, Yuzo Nakao
    PURPOSE: To evaluate the efficacy and safety of intravenous "freeze-dried sulfonated human normal immunoglobulin (GGS)" in patients with steroid-resistant optic neuritis (ON). STUDY DESIGN: Multicenter, prospective, double-blind, parallel-group, randomized controlled trial. METHODS: Patients with steroid-resistant acute ON were randomly assigned to receive either intravenous GGS (GGS group) or intravenous methylprednisolone (steroid pulse [SP] group). Visual acuity (logarithm of the minimum angle of resolution [logMAR]), mean deviation (MD) value of the Humphrey Field Analyzer, and critical flicker fusion frequency were measured as efficacy endpoints; adverse events (AEs) were assessed as the safety endpoint. RESULTS: Thirty-two patients (16 patients/group) received the study drugs. The primary endpoint, change in logMAR at week 2 compared to baseline, showed no statistically significant intergroup difference. However, compared with the SP group, change in the GGS group was increasingly indicative of visual improvement, with least squares mean difference of > 0.3 logMAR. On post-hoc analyses, the percentage of patients in the GGS and SP groups with improvement by ≥ 0.3 logMAR at week 2 were 75.0% and 31.3%, respectively. Changes in MD values at week 2 compared to baseline were 9.258  ±  8.296 (mean ± standard deviation) dB and 3.175  ±  6.167 dB in the GGS and SP groups, respectively. These results showed statistically significant intergroup differences (visual acuity improvement, P = 0.032; change in MD values, P = 0.030). No clinically significant AEs were observed. CONCLUSION: Our results suggest that intravenous immunoglobulin could be a safe and efficacious therapeutic option for prompt treatment of steroid-resistant acute ON. TRIAL REGISTRATION: JapicCTI-132080.
    Jan. 2021, Japanese journal of ophthalmology, 65(1) (1), 122 - 132, English, Domestic magazine
    Scientific journal

  • Akiko Miki, Sentaro Kusuhara, Tsuyoshi Otsuji, Yu Kawashima, Katsuaki Miki, Hisanori Imai, Makoto Nakamura, Akitaka Tsujikawa
    This multicenter retrospective study was conducted to evaluate the 1-year treatment outcome of photodynamic therapy (PDT) combined with anti-vascular endothelial growth factor (VEGF) therapy for pachychoroid neovasculopathy (PNV). A total of 42 eyes of 42 patients with treatment-naïve PNV who were treated with PDT combined with intravitreal injections of an anti-VEGF agent (ranibizumab or aflibercept) for 1 year. All eyes showed exudative and/or hemorrhagic changes that affected the fovea at baseline. After the initial combination therapy, subfoveal choroidal thickness (SCT) and central retinal thickness (CRT) were significantly reduced and were maintained as such for 12 months (P < 0.01 in SCT and CRT). The best-corrected visual acuity (BCVA) (0.19 ± 0.30 at baseline) significantly improved at 3 months (0.15 ± 0.29, P < 0.05) and further improved at 12 months (0.10 ± 0.30, P < 0.01) when compared to that at baseline. After the initial combination therapy, 32 eyes (76.2%) required no additional treatments for 12 months. The mean number of additional PDT and intravitreal injections of anti-VEGF agents was 0.1 ± 0.3 and 0.9 ± 1.9, respectively. Of the 42 eyes included in this study, 22 eyes (52.4%) had polypoidal lesions at baseline. No significant differences in SCT, CRT, or BCVA were observed at any time points between eyes with and without polypoidal lesions. Of 20 eyes without polypoidal lesions, only 1 eye (5.0%) needed additional treatments. PNV, especially without polypoidal lesions, can be treated effectively with PDT combined with anti-VEGF therapy with few sessions.
    2021, PloS one, 16(3) (3), e0248760, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hisanori Imai, Akira Tetsumoto, Hiroko Yamada, Makoto Nakamura
    The present study aimed to identify the factors regulating aspiration rate (AR) of backflush needles and to compare those factors across various backflush needles from different manufacturers. The 27-gauge (27G), 25-gauge, and 23-gauge backflush needles from four different manufacturers, Alcon, MedOne, VitreQ, and DORC, were used for this experiment. AR was measured at four different aspiration vacuum levels: 100, 200, 400, and 650 mmHg. AR was significantly increased as the aspiration vacuum level increased when both aspirating balanced salt solution (BSS) and ethylene glycol; however, 27G products from VitreQ and MedOne were unable to aspirate ethylene glycol at the low aspiration vacuum level of 100 mmHg. When aspirating BSS at the high aspiration vacuum level of 650 mmHg, a smaller gauge number generally resulted in a significantly higher AR. AR, inner diameter, and cross-sectional area in Alcon products were significantly larger in any gauge, and the shaft length of Alcon products was significantly shorter than those of other manufacturers' products in any gauge. Cross-sectional area negatively correlated with the degree of shaft deflection (r2 = 0.21, p = 0.042). These results imply that AR differs significantly among backflush needles and among companies depending on the shaft cross-sectional area.
    Dec. 2020, Scientific reports, 10(1) (1), 21452 - 21452, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 島内 深希, 林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    (公社)日本視能訓練士協会, Dec. 2020, 日本視能訓練士協会誌, 49, 246 - 246, Japanese

  • Hisanori Imai, Akira Tetsumoto, Hiroko Yamada, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Makoto Nakamura
    PURPOSE: To show surgical results of the intraoperative three-dimensional fluorescein angiography (3D-FA)-guided pars plana vitrectomy (PPV) for branch retinal vein occlusion (BRVO) with vitreous hemorrhage (VH) and neovascularization elsewhere (NVE). METHODS: The NGENUITY 3D ® visualization system was used for the digital assisted vitrectomy (DAV). 3D-FA-guided PPV was performed in three patients with BRVO with VH and NVE. PATIENTS: 3 eyes with BRVO with VH and NVE RESULTS:: In all eyes, the scatter retinal photocoagulations for nonperfusion area (NPA), depicted as hypofluorescein, and the segmentation and delamination of perivascular fibrovascular proliferative membrane, depicted as hyperfluorescein, could be safely performed on the same screen while implementing intraoperative 3D-FA. CONCLUSIONS: 3D-FA-guided PPV, a novel approach that fully utilizes the advantages of DAV, can be one of useful techniques for the treatment of BRVO with VH and NVE.
    Nov. 2020, Retinal cases & brief reports, 16(6) (6), 802 - 805, English, International magazine
    Scientific journal

  • Sotaro Mori, Takuji Kurimoto, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Norio Chihara, Yuko Yamada-Nakanishi, Makoto Nakamura
    Purpose. Although oral prednisolone is the first-line treatment for preventing recurrent optic neuritis (ON) after the completion of acute-phase treatment, especially anti-aquaporin 4 (AQP4) antibody-positive ON, and anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive ON, some patients experience relapses. Immunosuppressants could be effective in reducing the recurrence rate for neuromyelitis optica spectrum disorder and MOG antibody-related diseases, but there have been few studies addressing this issue focusing on the changes in ophthalmic parameters. The objective of the study was to analyze the impact of off-label uses of immunosuppressants to reduce recurrent ON. Design. Retrospective observational study, clinical case series. Methods. We reviewed the medical charts of 11 cases (22 eyes) who underwent immunosuppressive therapy in Kobe University Hospital and compared the annualized relapse rate (ARR) before and after immunosuppressive therapy. We also evaluated the dosage of prednisolone, complications of immunosuppressants, and other visual functional ophthalmologic parameters. Results. Eleven cases in total had AQP4 antibody (9 cases) and/or MOG antibody (3 cases). One case was double positive for these antibodies. Nine patients received azathioprine and two received mycophenolate mofetil as an initial immunosuppressive therapy. The median duration of immunosuppressant treatment was 2.8 years. The median ON ARR before immunosuppressive therapy was 0.33, and this decreased significantly to 0 after the therapy ( p = 0.02 ). The dose of prednisolone was reduced from 17.8 ± 7.1 mg/day before to 5.8 ± 2.2 mg/day after immunosuppressive therapy ( p < 0.01 ). Although two patients presented with mild elevation of liver enzymes and nausea, all patients were able to continue taking the immunosuppressants. Conclusions. Immunosuppressants can potentially decrease relapses and steroid dosage in patients with anti-AQP4 or MOG antibody-positive ON without severe adverse events and the exacerbation of visual acuities.
    Hindawi Limited, Nov. 2020, Journal of Ophthalmology, 2020, 1 - 6
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 岸本 真椰, 上田 香織, 高野 史生, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 55 - 55, Japanese

  • 井之上 杏奈, 栗本 拓治, 魚住 洋一, 高野 史生, 村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 谷口 理章, 中村 誠
    日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 71 - 71, Japanese

  • 村井 佑輔, 栗本 拓治, 高野 史生, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2020, 神経眼科, 37(増補1) (増補1), 72 - 72, Japanese

  • 視力良好なポリープ状脈絡膜血管症に対する硝子体注射併用光線力学的療法の1年経過
    中井 駿一朗, 三木 明子, 松宮 亘, 林田 真由香, 本田 茂, 中村 誠
    眼科臨床紀要会, Nov. 2020, 眼科臨床紀要, 13(11) (11), 752 - 753, Japanese

  • 視力良好な中心性漿液性脈絡網膜症における治療後不等像視の関連因子についての検討
    林田 真由香, 三木 明子, 島内 深希, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    眼科臨床紀要会, Nov. 2020, 眼科臨床紀要, 13(11) (11), 756 - 756, Japanese

  • サイトメガロウイルス虹彩毛様体炎続発緑内障の手術成績
    村井 佑輔, 盛 崇太朗, 高野 史生, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 80 - 80, Japanese

  • 血栓予防薬の緑内障手術における内服状況と術後の影響
    高野 史生, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 81 - 81, Japanese

  • 緑内障眼におけるアイモ両眼ランダム測定の有用性の検討
    林 由紀子, 坂本 麻里, 高野 史生, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 166 - 166, Japanese

  • 緑内障眼におけるアイモ両眼ランダム測定の中心窩感度および信頼係数の検討
    坂本 麻里, 高野 史生, 村井 佑輔, 西庄 龍東, 林田 真由香, 盛 崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠
    日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 166 - 166, Japanese

  • Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Mari Sakamoto, Norio Chihara, Wataru Satake, Yuko Yamada-Nakanishi, Makoto Nakamura
    Purpose: We report a case of neurosarcoidosis that presented simultaneously with oculomotor nerve palsy, contralateral abducens nerve palsy, and paresthesia of both lower limbs. Observations: A 69-year-old Japanese woman who suffered from repeated diplopia and lower-limb paresthesia was referred to our hospital. Ophthalmic findings included oculomotor nerve and contralateral abducens nerve palsies. No remarkable abnormalities were detected via enhanced brain magnetic resonance imaging (MRI), chest X-ray, and cerebrospinal fluid analysis. Chest computed tomography (CT) was performed to exclude neoplastic lesions; this revealed right hilar lymphadenopathy, and positron emission tomography MRI showed strong 18-F fluorodeoxyglucose uptake in the hilar lymph node. Biopsy of the lymph node showed non-caseating epithelioid granulomatous tissue, leading to a diagnosis of probable neurosarcoidosis. After the initiation of oral prednisolone treatment, the patient experienced complete remission without any recurrence. Conclusions and importance: When examining a patient presenting with multiple cranial neuropathies of unknown cause, neurosarcoidosis should be considered as a differential diagnosis and chest CT should be performed even when the chest X-ray and angiotensin-converting enzyme appears normal.
    Sep. 2020, American journal of ophthalmology case reports, 19, 100796 - 100796, English, International magazine
    Link to Kobe Univ. Repository (Kernel)

  • Mayuka Hayashida, Akiko Miki, Shigeru Honda, Makoto Nakamura
    BACKGROUND AND OBJECTIVES: This study aimed to compare the efficacy of fluorescein angiography (FA)-guided and indocyanine green angiography (ICGA)-guided half-time photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). SUBJECTS AND METHODS: Medical records of 61 eyes of 61 CSC patients who underwent half-time PDT were retrospectively reviewed. The irradiation area was determined using information from FA or ICGA with physicians' discretion. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), subfoveal choroidal thickness (SCT), and resolution of subretinal fluid (SRF) were evaluated at baseline and 1, 3, 6, and 12 months after PDT. RESULTS: A total of 29 and 32 eyes received FA-guided PDT (irradiation area, 2898.3 ± 705.7 μm) and ICGA-guided PDT (irradiation area, 4993.8 ± 333.1 μm), respectively. A significant improvement in the mean BCVA was found at 1 month in the FA-guided group (P = 0.02), but not in the ICGA-guided group (P = 0.88). BCVA was significantly improved in both groups at 3, 6, and 12 months with no significant intergroup difference at any time points. CRT and SCT were significantly reduced in both groups at all time points with no significant intergroup differences. No significant intergroup differences were observed in the rate of recurrence and persistent SRF. However, there was a significant difference between groups in the rate of recurrence and/or persistent SRF (P = 0.04). Multivariate analysis revealed that choice of FA-guided was significantly associated with recurrence and/or persistent SRF (P = 0.04). CONCLUSION: Half-time PDT with ICGA-guided irradiation spot might be more effective than that with FA-guided in treating CSC patients in complete resolution of SRF.
    Aug. 2020, Photodiagnosis and photodynamic therapy, 31, 101955 - 101955, English, International magazine
    [Refereed]
    Scientific journal

  • Saki Inoue, Hisanori Imai, Akira Tetsumoto, Keiko Otsuka, Makoto Nakamura
    S. Karger AG, Aug. 2020, Case Reports in Ophthalmology, 11(2) (2), 436 - 441
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Sotaro Mori, Takuji Kurimoto, Akiko Miki, Hidetaka Maeda, Sentaro Kusuhara, Makoto Nakamura
    Aquaporin 9 (AQP9) is an aquaglyceroporin that can transport lactate. Accumulating evidence suggests that astrocyte-to-neuron lactate shuttle (ANLS) plays a critical role in energy metabolism in neurons, including retinal ganglion cells (RGCs). To test the hypothesis that AQP9, in concert with monocarboxylate transporters (MCTs), participates in ANLS to maintain function and survival of RGCs, Aqp9-null mice and wild-type (WT) littermates were subjected to optic nerve crush (ONC) with or without intravitreal injection of an MCT2 inhibitor. RGC density was similar between the Aqp9-null mice and WT mice without ONC, while ONC resulted in significantly more RGC density reduction in the Aqp9-null mice than in the WT mice at day 7. Positive scotopic threshold response (pSTR) amplitude values were similar between the two groups without ONC, but were significantly more reduced in the Aqp9-null mice than in the WT mice 7days after ONC. MCT2 inhibitor injection accelerated RGC death and pSTR amplitude reduction only in the WT mice with ONC. Immunolabeling revealed that both RGCs and astrocytes expressed AQP9, that ONC predominantly reduced astrocytic AQP9 expression, and that MCTs 1, 2, and 4 were co-localized with AQP9 at the ganglion cell layer. These retinal MCTs were also co-immunoprecipitated with AQP9 in the WT mice. ONC decreased the co-immunoprecipitation of MCTs 1 and 4, but did not impact co-immunoprecipitation of MCT2. Retinal glucose transporter 1 expression was increased in Aqp9-null mice. Aqp9 gene deletion reduced and increased the intraretinal L-lactate and D-glucose concentrations, respectively. Results suggest that AQP9 acts as the ANLS to maintain function and survival of RGCs.
    Aug. 2020, Molecular neurobiology, 57(11) (11), 4530 - 4548, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Hisanori Imai, Akira Tetsumoto, Hiroko Yamada, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    PURPOSE: To show the long-term effect of the cystotomy with or without fibrinogen clot removal for the refractory cystoid macular edema (CME) secondary to diabetic retinopathy (DR). METHODS: Retrospective analyses of the medical records of 30 eyes of 30 patients with refractory CME secondary to DR who had followed-up for 12 months after the surgery were performed. RESULTS: There were 15 men and 15 women. The mean±SD age was 68.4±7.9 years. The best corrected visual acuity (BCVA) (logMAR) at 12 months after the surgery (0.33±0.25, Snellen equivalent (SE), 20/42) was statistically better than the preoperative BCVA (0.45±0.33, SE, 20/56) (p<0.01). The central sensitivity on microperimetry (dB) was not statistically changed between preoperatively (24.0±4.9) and 12 months after the surgery (24.1±4.0) (p=0.75). The central retinal thickness (CRT) on optical coherence tomography (OCT) (μm) at 12 months after the surgery (300.3±99.0) was statistically improved compared with the preoperative CRT (565.6±198.7) (p<0.01). During the follow-up period, CME relapsed in 7 of 30 eyes. The preoperative cystoid cavity reflectivity on OCT in patients with fibrinogen clot removal (n=16) was significantly higher compared with that in patients without fibrinogen clot removal (n=14) (p<0.04). CONCLUSION: The cystotomy with or without fibrinogen clot removal may be a promising treatment option for refractory CME secondary to DR.
    Jul. 2020, Retina (Philadelphia, Pa.), 41(4) (4), 844 - 851, English, International magazine
    [Refereed]
    Scientific journal

  • Daiki Sakai, Wataru Matsumiya, Sentaro Kusuhara, Makoto Nakamura
    Elsevier Inc, Jun. 2020, American Journal of Ophthalmology Case Reports, 18, English
    Scientific journal

  • 坂本 麻里, 中村 誠
    (株)全日本病院出版会, Jun. 2020, OCULISTA, (87) (87), 45 - 51, Japanese

  • 林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Jun. 2020, 日本眼科学会雑誌, 124(6) (6), 465 - 471, Japanese

  • 治療維持期の視力不良な滲出型加齢黄斑変性患者の固視
    林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Jun. 2020, 日本眼科学会雑誌, 124(6) (6), 465 - 471, Japanese

  • Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Seiko Kamada, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura
    Leber hereditary optic neuropathy (LHON) is an intractable disease associated with mitochondrial DNA (mtDNA) mutations. In this preliminary, single-arm, prospective, open-label exploratory trial, we investigated the effectiveness and safety of skin electrical stimulation (SES) for cases of LHON harboring the mtDNA 11,778 mutation. Of the 11 enrolled patients, 10 completed six sessions of SES once every two weeks over a 10-week period. The primary outcome measure was the change in logarithm of the minimum angle of resolution (logMAR)-converted best-corrected visual acuity (BCVA) at one week after the last session of SES. The main secondary outcome measures were the logMAR BCVA at four and eight weeks and Humphrey visual field test sensitivities at one, four, and eight weeks. At all follow-up points, the logMAR BCVA had improved significantly from baseline [1.80 (1.70–1.80) at baseline, 1.75 (1.52–1.80) at one week, 1.75 (1.50–1.80) at four weeks, and 1.75 (1.52–1.80) at eight weeks; p < 0.05]. At eight weeks of follow-up, five patients showed >2-fold increase in the summed sensitivity at 52 measurement points from baseline. No adverse effects were observed. In conclusion, SES could be a viable treatment option for patients with LHON in the chronic phase harboring the mtDNA 11,778 mutation.
    May 2020, Journal of clinical medicine, 9(5) (5), English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 山田 裕子, 上田 香織, 長井 隆行, 中西 裕子[山田], 中村 誠
    (株)医学書院, May 2020, 臨床眼科, 74(5) (5), 627 - 630, Japanese

  • Hisanori Imai, Akira Tetsumoto, Saki Inoue, Fumio Takano, Hiroko Yamada, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    PURPOSE: To show the usefulness of the intraoperative three-dimensional fluorescein angiography (3D-FA)-guided pars plana vitrectomy. METHODS: The NGENUITY 3D visualization system was used for the digital assisted vitrectomy. Three-dimensional fluorescein angiography-guided pars plana vitrectomy was performed in three patients with vitreous hemorrhage secondary to proliferative diabetic retinopathy. We investigated both whether several angiographic findings can be successfully displayed on the screen during 3D-FA and whether pars plana vitrectomy can be performed simultaneously on the same screen while implementing 3D-FA. RESULTS: In all cases, the abnormal FA findings including hypofluorescence due to non-perfusion areas, and the hyperfluorescence due to macular edema and fibrovascular proliferative membrane were successfully displayed on the screen. The segmentation and delamination of fibrovascular proliferative membrane and panretinal photocoagulation for detected non-perfusion areas were able to be performed on the same screen while implementing 3D-FA. CONCLUSION: Three-dimensional fluorescein angiography-guided pars plana vitrectomy is a novel approach that fully utilizes the advantages of digital assisted vitrectomy and a promising option for the treatment of proliferative diabetic retinopathy.
    Apr. 2020, Retina (Philadelphia, Pa.), English, International magazine
    [Refereed]
    Scientific journal

  • Nobuyuki Sasaki, Mari Sakamoto, Takuji Kurimoto, Sotaro Mori, Kaori Ueda, Yuko Nakanishi, Kenta Ijima, Hisatsugu Tachibana, Makoto Nakamura
    Neuro-Ophthalmology Society of Japan, Mar. 2020, Neuro-Ophthalmology Japan, 37(1) (1), 38 - 44, Japanese
    Scientific journal

  • マイクロフックトラベクロトミーの切開範囲による術後短期成績の比較
    盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 212 - 212, Japanese

  • 傾向スコア解析による毛様溝挿入アーメド/バルベルトインプラントの術後短期成績
    村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 216 - 216, Japanese

  • 上皮増殖因子受容体チロシンキナーゼ阻害薬が原因と考えられる眼障害の検討
    曽谷 尭之, 山田 裕子, 鉄本 章, 盛 崇太朗, 坂本 麻里, 長井 隆行, 中村 誠
    (公財)日本眼科学会, Mar. 2020, 日本眼科学会雑誌, 124(臨増) (臨増), 292 - 292, Japanese

  • 佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太朗, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠
    日本神経眼科学会, Mar. 2020, 神経眼科, 37(1) (1), 38 - 44, Japanese

  • Atsuko Katsuyama, Sentaro Kusuhara, Shun-Ichiro Asahara, Shun-Ichiro Nakai, Sotaro Mori, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Yoshiaki Kido, Wataru Ogawa, Makoto Nakamura
    OBJECTIVE: To evaluate the usefulness of en face slab optical coherence tomography (OCT) imaging for monitoring diabetic retinal neurodegeneration with supporting animal experimental data. RESEARCH DESIGN AND METHODS: We retrospectively examined 72 diabetic eyes over 3 years using Cirrus-HD OCT. Two-dimensional en face slab OCT images of the innermost retina were reconstructed and graded according to the ratio of dark area to total area, and relative red, green, and blue color area ratios were calculated and used as indexes for each en face slab OCT image. Values from en face OCT images were used for statistical analyses. To obtain insight into the pathogenesis of diabetic retinal neurodegeneration, we used the InsPr-Cre;Pdk1flox/flox diabetic mouse model. RESULTS: Both OCT grade and relative red color area ratio significantly increased with the advancing stage of diabetic retinopathy (p=0.018 and 0.006, respectively). After a mean follow-up period of 4.6 years, the trend was unchanged in the analyses of 42 untreated eyes (p<0.001 and 0.001, respectively). Visual acuity showed a weak but significant negative correlation with the red color ratio on en face slab OCT images, but central retinal thickness did not exhibit a clinically meaningful correlation with values obtained from en face slab OCT images. Immunohistochemical analyses of InsPr-Cre;Pdk1flox/flox diabetic mice demonstrated the loss of ganglion axon bundles and thinning of laminin without apparent retinal vascular change at the age of 20 weeks. CONCLUSIONS: En face slab OCT imaging would be a novel useful modality for the assessment of diabetic retinal neurodegeneration as it could detect subtle optical changes occurring in the innermost retina in diabetic eyes. Our animal experimental data suggest that dark areas observed on en face slab OCT images might be the impairment of the extracellular matrix as well as neurons.
    Mar. 2020, BMJ open diabetes research & care, 8(1) (1), English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kaori Ueda, Akiko Miki, Shunichiro Nakai, Suiho Yanagisawa, Koji Nomura, Makoto Nakamura
    PURPOSE: To retrospectively investigate the sensitivity and specificity of weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity (WINROP) algorithm for the prediction of severe retinopathy of prematurity (ROP) in a Japanese population of preterm infants. The WINROP algorithm is a tool based on postnatal weight gain. STUDY DESIGN: Retrospective cohort study. METHODS: The medical records of preterm infants born between January 2011 and March 2017 were retrospectively reviewed. Infants born after 33 weeks of gestation were excluded based on the indications of the WINROP algorithm. Postnatal weight was recorded weekly on the WINROP system until postmenstrual week 36. The sensitivity and specificity of the WINROP algorithm were analyzed. RESULTS: In total, 278 infants were included in this study. Based on the WINROP algorithm 110 of these infants were predicted to be at low risk for developing severe ROP and 105 did not develop severe ROP. Based on the WINROP algorithm 168 infants were predicted to be at high risk for developing severe ROP and 27 developed severe ROP. Thus, the sensitivity of the WINROP algorithm was 84.4% and the specificity 42.7%. CONCLUSION: The WINROP algorithm could be used for preterm infants (gestational age of <28 weeks) without a complicated hospital course. Modification of the algorithm will improve its sensitivity and specificity for the Japanese population.
    Mar. 2020, Japanese journal of ophthalmology, 64(2) (2), 223 - 227, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Akira Tetsumoto, Hisanori Imai, Mayuka Hayashida, Keiko Otsuka, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
    OBJECTIVES: To compare the surgical results between air and 20% sulfur hexafluoride (SF6) tamponade in 27-gauge pars plana vitrectomy (27GPPV) for rhegmatogenous retinal detachment (RRD). METHODS: A retrospective, observational, and consecutive study. All patients underwent 27GPPV for RRD were divided into two groups. Group A comprised patients who underwent 20% SF6 gas tamponade. Group B comprised patients who underwent air tamponade. The anatomical success rate, visual outcome, and the type and frequency of complications were investigated and compared between the groups. All patients were followed-up for 12 months after surgery. RESULTS: Seventy eyes were enrolled (Group A: 35 eyes, Group B: 35 eyes). Seventeen eyes in Group A and 13 eyes in Group B had RRD with superior retinal breaks, while 14 eyes in Group A and 19 eyes in Group B had RRD with inferior retinal breaks. There was no statistically difference in preoperative demographic date between the groups. The initial and final anatomical success rates were 97.1% and 100% in Group A and 94.3% and 100% in Group B, respectively. The success rates between the groups were not statistically different (p = 1). The best corrected visual acuity (BCVA) (logMAR) at 12 months after surgery was -0.02 ± 0.14 in Group A and -0.03 ± 0.27 in Group B. The BCVA between the groups was not statistically different (p = 0.27). CONCLUSIONS: The surgical results of air tamponade were not inferior to 20% SF6 tamponade in 27GPPV for RRD irrespective of retinal break locations in the present cohort.
    Feb. 2020, Eye (London, England), 34(2) (2), 299 - 306, English, International magazine
    [Refereed]
    Scientific journal

  • Scleral baring secondary to conjunctivitis by Pseudomonas aeruginosa in an immunologically healthy adult
    Hiroko Yamada, Kaori Ueda, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura
    Igaku-Shoin Ltd, 2020, Japanese Journal of Clinical Ophthalmology, 74(5) (5), 627 - 630, Japanese
    Scientific journal

  • Mayuka Hayashida, Akiko Miki, Shunichiro Nakai, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    This retrospective study was conducted to investigate the predictive factors associated with metamorphopsia after reduced-fluence photodynamic therapy (RFPDT) in patients with central serous chorioretinopathy (CSC) with good baseline visual acuity. A total of 36 eyes of 36 consecutive patients with resolved CSC after RFPDT and best-corrected visual acuity (BCVA) better than 1.0 (logarithm of the minimal angle of resolution (logMAR) 0) at baseline were examined. Metamorphopsia was measured using M-CHARTS at 12 months after RFPDT. An average of the horizontal and vertical M-CHARTS scores was applied for defining the extent of metamorphopsia. The association between M-CHARTS score at 12 months after RFPDT and clinical parameters (age, sex, duration of symptoms, BCVA, and findings of optical coherence tomography (OCT)) was investigated at baseline or 12 months after RFPDT. The M-CHARTS score at 12 months correlated significantly with duration of symptoms (P = 0.005), baseline outer nuclear layer (ONL) thickness (P = 0.009), central foveal thickness (CFT) (P = 0.001) at 12 months, and ONL thickness (P = 0.001) at 12 months after RFPDT. In the multivariate analysis of baseline-related factors, thinner ONL thickness before RFPDT (P = 0.010) was significantly associated with large metamorphopsia at 12 months after RFPDT in CSC patients with good baseline BCVA. Baseline ONL thickness may be a useful predictive factor of metamorphopsia after RFPDT in CSC patients with good baseline BCVA.
    2020, PloS one, 15(10) (10), e0240557, English, International magazine
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Genetic factors associated with treatment response to reduced-fluence photodynamic therapy for chronic central serous chorioretinopathy.
    Mayuka Hayashida, Akiko Miki, Shunichiro Nakai, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Shigeru Honda, Makoto Nakamura
    Purpose: Reduced-fluence photodynamic therapy (RFPDT) has proven effective for some patients with chronic central serous chorioretinopathy (cCSC). Several clinicodemographic factors influencing treatment response have been identified, but associations with genetic factors have not been examined. Therefore, we investigated the associations of single nucleotide polymorphisms (SNPs) implicated in cCSC pathogenesis with clinical outcome following RFPDT. Methods: This was a retrospective study of 87 eyes from 87 patients with cCSC who underwent RFPDT and were followed up for more than 12 months. Patients were divided into a good response group (53 patients) and a poor response group (34 patients) based on either persistence or recurrence of subretinal fluid detected with spectral domain optical coherence tomography after the first application of RFPDT. SNPs in the genes encoding age-related maculopathy susceptibility protein 2 (ARMS2, SNP rs10490924) and complement factor H (CFH, SNP rs800292) were genotyped using TaqMan technology. Results: There were no statistically significant differences in the baseline characteristics between the response groups except the degree of hyperfluorescence on indocyanine green angiography (ICGA; p = 0.011). The minor (T) allele frequency of ARMS2 (rs10490924) were statistically significantly lower in the good response group than in the poor response group (24.0% versus 41.0%, p = 0.021). Further, the good response frequency was statistically significantly lower in patients with at least one minor allele (GT or TT) compared to the homozygous major allele group (GG; p<0.05). The baseline best-corrected visual acuity (BCVA) at 12 months after RFPDT was statistically significantly better in the GG carriers than in the GT or TT carriers (p<0.01). Logistic regression analysis showed less intense hyperfluorescence on ICGA, and the T allele of ARMS2 (rs10490924) was statistically significantly associated with poor response to PDT treatment (p = 0.012, p = 0.039, respectively). Conclusions: Carriers of the ARMS2 rs10490924 minor allele (GT or TT) demonstrated a higher subretinal fluid persistence or recurrence rate and poorer visual outcome following RFPDT. In addition to the ICGA findings, genotyping of ARMS2 (rs10490924) may assist in the selection of patients with cCSC most likely to benefit from RFPDT.
    2020, Molecular vision, 26, 505 - 509, English, International magazine
    [Refereed]
    Scientific journal

  • Sotaro Mori, Yusuke Murai, Kaori Ueda, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    Objective: To compare the 1-year outcomes of trabeculotomy ab externo (ab externo TLO) and trabeculotomy ab interno using a microhook (ab interno TLO) for glaucoma patients using propensity score analysis. Methods and analysis: The medical charts of 65 consecutive patients who underwent ab externo TLO and those of 69 patients who underwent ab interno TLO were reviewed. Logistic regression analysis was conducted to calculate the propensity score using 1:1 matched analysis, which indicates the likelihood of surgical success at 12 months. We set the outcome-related covariates as age, glaucoma type, mean deviation, preoperative intraocular pressure (IOP), the number of preoperative glaucoma eye drops and the presence or absence of combined cataract surgery. Fifty eyes per each surgery group were subsequently compared. Results: The mean preoperative IOP was 32.5±11.2 mm Hg in the ab externo TLO group and 28.4±7.8 mm Hg in the ab interno TLO group (p=0.08). The mean postoperative IOP at 12 months was 18.3±7.4 mm Hg in the former group and 17.8±6.3 mm Hg in the latter (p=0.91). When surgical success was defined as a postoperative IOP of between 5 and 21 mm Hg with a more than 20% IOP reduction from baseline and no additional glaucoma surgery, the rate at 12 months was 78% in the ab externo TLO group and 74% in the ab interno TLO group (p=1.00). Conclusion: The 1-year success rate was not significantly different between ab externo and ab interno TLO.
    2020, BMJ open ophthalmology, 5(1) (1), e000446, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akira Tetsumoto, Hisanori Imai, Akiko Miki, Makoto Nakamura
    BACKGROUND/PURPOSE: To present a case report of retinal metastasis of laryngeal squamous cell carcinoma that was diagnosed by a histopathologic finding from the surgically extracted tumor tissue. METHODS: A 66-year-old man, who was suffered from the treatment-resistant laryngeal carcinoma, was referred to our department because of visual field defect in his right eye. A fundus examination revealed a parafoveal white retinal lesion, which rapidly expanded to the central fovea and decreased the visual acuity. A tissue extraction by 27G pars plana vitrectomy was performed to confirm the diagnosis. RESULTS: The abnormal retinal tissue was extracted en block through 10-mm sclerocorneal tunnel during pars plana vitrectomy. The histopathologic findings revealed that the retinal lesion was retinal metastasis of laryngeal carcinoma. CONCLUSION: We must keep in mind that retinal metastasis can be one of the differential diagnoses for white retinal lesions of unknown cause.
    2020, Retinal cases & brief reports, 14(2) (2), 127 - 130, English, International magazine
    [Refereed]
    Scientific journal

  • Hisanori Imai, Keiko Otsuka, Akira Tetsumoto, Akiko Miki, Makoto Nakamura
    PURPOSE: To introduce the methodology and outcomes of en bloc removal of the component of cystoid lesion during pars plana vitrectomy as a novel approach for the treatment of cystoid macular edema and show evidence that the component is an aggregation of fibrinogen by mass spectrometry analysis. METHODS: The surgical en bloc extraction of the component of cystoid lesion was performed for cystoid macular edemas secondary to diabetic retinopathy and retinal vein occlusion. Perioperative change of best-corrected decimal visual acuity, and the central retinal thickness and the continuity of subfoveal ellipsoid zone and external limiting membrane on optical coherence tomography were evaluated. Mass spectrometry was performed for the identification of protein constituting the component. RESULTS: Six eyes from six patients were included in the study. In all cases, central retinal thickness was improved after the surgery and remained stable during the follow-up period. Best-corrected decimal visual acuity and the continuity of ellipsoid zone and external limiting membrane were kept in all cases during the follow-up period. The mass spectrometry analysis disclosed that the component was composed of fibrinogen. CONCLUSION: The en block removal of the component of cystoid lesion combined with pars plana vitrectomy may be a promising option for treatment of cystoid macular edema. The component of cystoid lesion is presumably a fibrinogen aggregate.
    Jan. 2020, Retina (Philadelphia, Pa.), 40(1) (1), 154 - 159, English, International magazine
    [Refereed]
    Scientific journal

  • 滲出型加齢黄斑変性の固視に関する検討
    林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2019, 眼科臨床紀要, 12(11) (11), 834 - 834, Japanese
    [Refereed]

  • 滲出型加齢黄斑変性の固視に関する検討
    林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2019, 眼科臨床紀要, 12(11) (11), 834 - 834, Japanese
    [Refereed]

  • TREX1遺伝子変異に伴うretinal vasculopathy with cerebral leukoencephalopathyの1例
    西庄 龍東, 楠原 仙太郎, 勝山 敦子, 松宮 亘, 中村 誠
    眼科臨床紀要会, Nov. 2019, 眼科臨床紀要, 12(11) (11), 854 - 854, Japanese
    [Refereed]

  • 視力良好な中心性漿液性脈絡網膜症における治療後不等像視の関連因子についての検討
    島内 深希, 林田 真由香, 三木 明子, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    日本視能矯正学会, Nov. 2019, 日本視能矯正学会プログラム抄録集, 60回, 89 - 89, Japanese
    [Refereed]

  • 非感染性ぶどう膜炎におけるアダリムマブ治療前後の鎮静化状態の達成とその臨床的意義
    楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    日本臨床免疫学会, Oct. 2019, 日本臨床免疫学会総会プログラム・抄録集, 47回, 126 - 126, Japanese
    [Refereed]

  • En face slab OCT像を用いた網膜静脈分枝閉塞症の乳頭黄斑線維束障害についての検討
    勝山 敦子, 楠原 仙太郎, 西庄 龍東, 松宮 亘, 中村 誠
    眼科臨床紀要会, Oct. 2019, 眼科臨床紀要, 12(10) (10), 769 - 769, Japanese
    [Refereed]

  • Hitoshi Ishikawa, Takeshi Kezuka, Keigo Shikishima, Akiko Yamagami, Miki Hiraoka, Hideki Chuman, Makoto Nakamura, Keika Hoshi, Toshiaki Goseki, Kimiyo Mashimo, Osamu Mimura, Takeshi Yoshitomi, Keiko Tanaka
    PURPOSE: To elucidate the clinical and epidemiologic characteristics of optic neuritis in Japan. DESIGN: Multicenter cross-sectional, observational cohort study. PARTICIPANTS: A total of 531 cases of unilateral or bilateral noninfectious optic neuritis identified in 33 institutions nationwide in Japan. METHODS: Serum samples from patients with optic neuritis were tested for anti-aquaporin-4 antibodies (AQP4-Abs) and anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) using a cell-based assay and were correlated with the clinical findings. MAIN OUTCOME MEASURES: Antibody positivity, clinical and radiologic characteristics, and visual outcome. RESULTS: Among 531 cases of optic neuritis, 12% were AQP4-Ab positive, 10% were MOG-Ab positive, 77% were negative for both antibodies (double-negative), and 1 case was positive for both antibodies. Pretreatment visual acuity (VA) worsened to more than a median 1.0 logarithm of the minimum angle of resolution (logMAR) in all groups. After steroid pulse therapy (combined with plasmapheresis in 32% of patients in AQP4-Ab-positive group), median VA improved to 0.4 logMAR in the AQP4-Ab-positive group, 0 logMAR in the MOG-Ab-positive group, and 0.1 logMAR in the double-negative group. The AQP4-Ab-positive group showed a high proportion of females, exhibited diverse visual field abnormalities, and demonstrated concurrent spinal cord lesions on magnetic resonance imaging (MRI) in 22% of the patients. In the MOG-Ab-positive group, although posttreatment visual outcome was good, the rates of optic disc swelling and pain with eye movement were significantly higher than those in the AQP4-Ab-positive and double-negative groups. However, most cases showed isolated optic neuritis lesions on MRI. In the double-negative group, 4% of the patients had multiple sclerosis. Multivariate logistic regression analysis of all participants identified age and presence of antibodies (MOG-Ab and AQP4-Ab) as significant factors affecting visual outcome. CONCLUSIONS: The present large-scale cohort study revealed the clinicoepidemiologic features of noninfectious optic neuritis in Japan. Anti-aquaporin-4 antibody-positive optic neuritis has poor visual outcome. In contrast, MOG-Ab positive cases manifested severe clinical findings of optic neuritis before treatment, but few showed concurrent lesions in sites other than the optic nerve and generally showed good treatment response with favorable visual outcome. These findings indicate that autoantibody measurement is useful for prompt diagnosis and proper management of optic neuritis that tends to become refractory.
    Oct. 2019, Ophthalmology, 126(10) (10), 1385 - 1398, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 毛様溝挿入アーメドインプラント手術の術後短期成績
    村井 佑輔, 盛 崇太朗, 栗本 拓治, 山田 裕子, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    日本緑内障学会, Sep. 2019, 日本緑内障学会抄録集, 30回, 77 - 77, Japanese

  • 視力良好な糖尿病黄斑浮腫に対する抗VEGF薬硝子体注射の12ヵ月治療成績
    楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    (一社)日本糖尿病合併症学会, Sep. 2019, 糖尿病合併症, 33(Suppl.1) (Suppl.1), 270 - 270, Japanese
    [Refereed]

  • Shunichiro Nakai, Wataru Matsumiya, Akiko Miki, Shigeru Honda, Makoto Nakamura
    PURPOSE: To determine the association of age-related maculopathy susceptibility 2 (ARMS2) gene polymorphisms with the 12-month outcomes of intravitreal aflibercept combined with photodynamic therapy (IVA+PDT) in polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Interventional cohort study. METHODS: This was a retrospective study of 48 consecutive treatment-naïve PCV patients. The patients underwent IVA+PDT as the initial therapy and were followed up for more than 12 months under a pro re nata regimen. The single nucleotide polymorphism (SNP) at rs10490924 in the ARMS2 gene was genotyped using the TaqMan assay. The clinical characteristics and outcomes of IVA+PDT were compared among the 3 genotypes at rs10490924. Multivariate regression analysis was performed to evaluate the influence of the clinical cofactors on the association of rs10490924 with the visual outcome at 12 months after the first IVA+PDT. RESULTS: No significant difference was found in the baseline characteristics among the 3 genotypes (n = 9, 23, and 16 for the GG, GT, and TT genotypes, respectively). All the patients, regardless of genotype, showed a significant improvement in vision, central retinal thickness, and subfoveal choroidal thickness at all time points measured after the initial IVA+PDT. The number of treatments was significantly smaller in the patients with the GG genotype than in those with the GT or the TT genotype. On multivariate logistic regression analysis, the number of the T allele at rs10490924 was significantly associated with the chance of retreatment after the initial IVA+PDT. CONCLUSION: The presence of the G allele at rs10490924 in the ARMS2 gene is likely associated with a lower chance of retreatment after IVA+PDT in patients with PCV.
    Sep. 2019, Japanese journal of ophthalmology, 63(5) (5), 389 - 395, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Atsuko Katsuyama, Sentaro Kusuhara, Hiroyuki Awano, Hiroaki Nagase, Wataru Matsumiya, Makoto Nakamura
    BACKGROUND: Vogt-Koyanagi-Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and the visual prognosis is worse than that in adult patients due to severe ocular complications secondary to recurrent inflammation. CASE PRESENTATION: A 3-year-old girl with probable VKH was referred to Kobe University Hospital. She had severe bilateral panuveitis with posterior synechiae of the iris, marked optic disk swelling, and serous retinal detachment in both eyes, and her best corrected visual acuities (BCVAs) were 20/200 OD and 20/125 OS. A third course of therapy was administered because serous retinal detachment remained after two courses of therapy. She was treated with three courses of high-dose intravenous corticosteroid therapy, followed by slow tapering of oral corticosteroids. Her BCVAs recovered to 20/16 OU, and relapse of ocular inflammation and side effect of treatment were not observed during the 1.5-year follow-up period. CONCLUSIONS: We experienced a pediatric patient with probable VKH disease who was treated with three courses of high-dose intravenous corticosteroid therapy. With the favorable clinical course in our patient, initial treatment with repeated high-dose intravenous corticosteroid therapy might be beneficial in pediatric VKH disease.
    Aug. 2019, BMC ophthalmology, 19(1) (1), 179 - 179, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 盛 崇太朗, 栗本 拓治, 村井 佑輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子[山田], 中村 誠
    日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 55 - 55, Japanese

  • 村井 佑輔, 栗本 拓治, 河原 佳奈, 山田 裕子, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 76 - 76, Japanese

  • 山田 裕子, 栗本 拓治, 上田 香織, 村井 佑輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠
    日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 88 - 88, Japanese

  • 三村 治, 中尾 雄三, 石川 均, 毛塚 剛司, 敷島 敬悟, 鈴木 利根, 中村 誠, 中馬 秀樹, 井上 賢治, 木村 亜紀子
    日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 55 - 55, Japanese

  • 下垂体茎断裂症候群に対するホルモン治療中に進行性の網膜変性症の合併を認めた1症例
    金 景佑, 松宮 亘, 勝山 敦子, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Aug. 2019, 眼科臨床紀要, 12(8) (8), 648 - 648, Japanese
    [Refereed]

  • 再発性視神経炎に対する免疫抑制剤の治療効果
    盛 崇太朗, 栗本 拓治, 村井 佑輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子[山田], 中村 誠
    日本神経眼科学会, Aug. 2019, 神経眼科, 36(増補1) (増補1), 55 - 55, Japanese
    [Refereed]

  • 糖尿病性黄斑浮腫に対するアフリベルセプト治療に影響する因子についての検討
    宮本 紀子, 楠原 仙太郎, 岩見 久司, 山本 庄吾, 吉水 聡, 吉武 信, 石田 和寛, 廣田 勇士, 本田 茂, 中村 誠, 池田 誠宏, 五味 文, 栗本 康夫
    日本糖尿病眼学会, Jul. 2019, 日本糖尿病眼学会誌, 23, 138 - 138, Japanese

  • Akira Tetsumoto, Hisanori Imai, Keiko Otsuka, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
    PURPOSE: To investigate the perioperative clinical factors, which contribute to the postsurgical aqueous flare intensity (AFI) following 27-gauge pars plana vitrectomy (27GPPV) for primary rhegmatogenous retinal detachment (RRD). STUDY DESIGN: Retrospective clinical study. METHODS: We performed retrospective analyses of the medical records of 47 eyes of 47 patients with primary RRD who had undergone 27GPPV with a wide-angle viewing system. AFI was measured preoperatively and 1 week, 1 month, 3 months, 6 months, and 12 months after the surgery. RESULTS: AFI was significantly increased 1 week after the surgery (p<0.01) and then decreased overtime. At 6 months after surgery it was still statistically significantly higher than preoperative AFI (p=0.03). There was no statistical difference between preoperative AFI and that at 12 months following surgery. Multiple regression analyses revealed that the number of retinal photocoagulations and the performance of scleral indentation had significant positive correlation with AFI at 1 week, 1 month, 3 months, and 6 months, and at 1 month and 3 months after the surgery, respectively. CONCLUSION: Intraoperative retinal photocoagulation and scleral indentation are probable causes of increased AFI after 27G PPV for RRD.
    Jul. 2019, Japanese journal of ophthalmology, 63(4) (4), 317 - 321, English, Domestic magazine
    [Refereed]
    Scientific journal

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada-Nakanishi, Makoto Nakamura
    Purpose: The present study aimed to assess the ability of en face slab images of maculae to detect residual nerve fiber bundles in eyes with advanced glaucoma. Methods: This study included 36 eyes with diffuse thinning of the ganglion cell and inner plexiform layers (GCL+IPL). Inclusion criterion was GCL+IPL thickness of <1% of the normative database level as detected using optical coherence tomography (OCT). En face slab images (50-μm thickness) were reconstructed from the macular cube scan data using advanced visualization settings. Thereafter, we assessed the agreement of the locations between hyperreflective nerve fiber bundles and normal points in the Humphrey visual field test 10-2 pattern deviation (PD) plots. Additionally, total deviation (TD) corresponding to hyperreflective and hyporeflective areas was compared. Results: Hyperreflective areas were detected in 31 out of 36 eyes; all 31 eyes exhibited at least one normal PD point despite the substantial GCL+IPL thinning in the macular region. Two eyes with abnormalities in all PD points showed no hyperreflective area. The remaining three eyes had normal PD points despite the lack of high reflectivity areas in the slab images. Therefore, 91.7% of eyes showed agreement between en face slab images and PD plots. Moreover, hyperreflective areas demonstrated significantly better TD than hyporeflective areas. Conclusions: En face slab images of maculae were able to reveal the residual nerve fiber bundles in the eyes with advanced glaucoma despite the GCL+IPL thickness in the maculae being diffusely and substantially reduced.
    Jul. 2019, Investigative ophthalmology & visual science, 60(8) (8), 2811 - 2821, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 序論 徹底討論！Visual pathway disorder
    中村 誠
    Jun. 2019, 神経眼科, 36(2) (2), 147 - 148, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • 視路疾患のOCT up-to-date
    坂本 麻里, 中村 誠
    May 2019, あたらしい眼科, 36(5) (5), 611 - 617, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • 序説 神経眼科診療を楽しもう！
    中村 誠
    May 2019, あたらしい眼科, 36(5) (5), 571 - 572, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Sotaro Mori, Takuji Kurimoto, Akiyasu Kanamori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Makoto Nakamura
    Purpose: The purpose of this study was to evaluate the concordance of a temporal raphe architecture estimated using optical coherence tomography (OCT) and MP-3 microperimetry. Methods: We enrolled 25 eyes with either an upper or lower glaucomatous hemifield defect, as detected on the Humphrey visual field 30-2 test. A structural temporal raphe was extrapolated from visible end points of retinal nerve fiber bundles present in a perimetrically normal hemiretina on an en face Spectralis OCT image. A functional temporal raphe was drawn as a line from the fovea to the border of at least a 10-dB difference in sensitivity, at vertically adjacent test points, with at least three consecutive pairs among 25 test points placed at 8° to 18° from the fovea (2° intervals) on the MP-3. An angle determined by the optic disc center, the fovea, and the temporal raphe line (the DFR angle) was calculated. Correlations and agreement of the OCT- and MP-3-derived DFR angles and factors affecting discordance of the two estimates were evaluated. Results: Despite no significant demographic differences, the functional DFR angle (mean ± SD, 171.8° ± 3.5°) was significantly larger than that of the structural DFR angle (166.5° ± 3.2°) in 14 eyes with upper hemifield defects and vice versa in 11 eyes with lower hemifield defects (163.4° ± 3.0° vs. 170.5° ± 3.2°). The mean deviation was significantly associated with the functional and structural DFR angle difference in eyes with only upper hemifield defects. Conclusions: The structural temporal raphe was more deviated to the perimetrically normal hemiretina side than to the functional temporal raphe, thereby suggesting that a structural change may precede a functional loss.
    Apr. 2019, Investigative ophthalmology & visual science, 60(5) (5), 1403 - 1411, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • マイクロパルス波経強膜毛様体光凝固術の術後短期成績
    村井 佑輔, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 258 - 258, Japanese

  • 網膜静脈分枝閉塞症に伴う黄斑浮腫における網膜最内層/内層/外層障害と視力予後の評価
    勝山 敦子, 楠原 仙太郎, 西庄 龍東, 松宮 亘, 中村 誠
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 213 - 213, Japanese
    [Refereed]

  • 糖尿病性黄斑浮腫に対する12ヵ月のアフリベルセプト治療成績に影響する因子の検討
    田中 沙織, 宮本 紀子, 楠原 仙太郎, 岩見 久司, 山本 庄吾, 吉武 信, 廣田 勇士, 中村 誠, 池田 誠宏, 五味 文, 栗本 康夫
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 216 - 216, Japanese
    [Refereed]

  • Vogt-小柳-原田病治療経過中の脈絡膜再肥厚と脈絡膜構造変化の検討
    松宮 亘, 西庄 龍東, 勝山 敦子, 宇治 彰人, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 224 - 224, Japanese
    [Refereed]

  • Vogt-小柳-原田病治療前後の脈絡膜構造指標の変化と相関
    西庄 龍東, 松宮 亘, 勝山 敦子, 宇治 彰人, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 273 - 273, Japanese
    [Refereed]

  • 視力良好な中心性漿液性脈絡網膜症における治療後歪視の予測因子についての検討
    林田 真由香, 三木 明子, 島内 深希, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    (公財)日本眼科学会, Mar. 2019, 日本眼科学会雑誌, 123(臨増) (臨増), 289 - 289, Japanese
    [Refereed]

  • 続発緑内障に対するテノン開創器を用いた線維柱帯切除術の短期成績
    楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Feb. 2019, 日本眼科学会雑誌, 123(2) (2), 121 - 127, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Hiroko Yamada, Takuji Kurimoto, Sotaro Mori, Mari Sakamoto, Kaori Ueda, Yuko Yamada-Nakanishi, Yoichi Uozumi, Hiroyasu Shose, Masaaki Taniguchi, Masanori Toyoda, Hironobu Minami, Makoto Nakamura
    2019, CASE REPORTS IN OPHTHALMOLOGY, 10(3) (3), 319 - 326, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mayuka Hayashida, Akiko Miki, Hisanori Imai, Keiko Otsuka, Atsushi Azumi, Makoto Nakamura
    BACKGROUND: Surgical intervention for dense vitreous hemorrhage (DVH) with unclear etiology is often delayed in favor of conservative follow-up despite possible disease progression and the availability of safe minimally invasive vitrectomy. OBJECTIVES: The aim of this study is to investigate the efficacy of early surgical intervention for DVH with unknown etiology. METHODS: Eighty-eight cases (88 eyes) of DVH with unknown origin were retrospectively reviewed. Inclusion criteria were as follows: (1) measured visual acuity (VA) of 20/200 or worse and (2) fundus invisibility requiring B-scan ultrasonography. Eyes with a history of diabetic retinopathy, recent trauma, or likely retinal detachment (RD) as revealed by B-scan ultrasonography were excluded. Outcome measures were a cause of vitreous hemorrhage and final VA following early (≤2 weeks after symptom onset) or delayed vitrectomy. RESULTS: The most frequently occurring causes of DVH were central or branch retinal vein occlusion (30 eyes, 34%) and retinal tear or RD (29 eyes, 33%). logMAR VA significantly improved after treatment (p < 0.001). Final VA was significantly higher for eyes treated within 2 weeks compared with eyes treated later than 2 weeks after symptom onset (p = 0.020). CONCLUSIONS: Surgical intervention within 2 weeks after symptom onset may prevent a lower visual outcome.
    2019, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 242(4) (4), 234 - 238, English, International magazine
    [Refereed]
    Scientific journal

  • Soutarou Mori, Takuji Kurimoto, Kana Kawara, Kaori Ueda, Mari Sakamoto, Yukako Keshi, Yuko Yamada-Nakanishi, Haruko Tachibana, Makoto Nakamura
    BACKGROUND: Invasive aspergillosis is often fatal. Here, we report a patient with invasive aspergillosis primarily involving the optic nerve diagnosed on autopsy. CASE PRESENTATION: A 77-year-old female with underlying diabetes mellitus, hyperlipidemia, and hypertension presented with disc swelling of the left eye. Although mini-pulse steroid therapy improved visual acuity (VA) of the left eye, it abruptly decreased to no light perception within a month, followed by a decrease in VA of the right eye to 0.5. At referral, VA was 0.3 in the right eye, and there was no light perception in the left eye. RESULTS: Fundus examination revealed optic disc swelling of both eyes. Goldmann perimetry showed irregular visual field defects, whereas magnetic resonance imaging (MRI), general, and cerebrospinal fluid (CSF) examinations revealed no distinct abnormalities. We suspected anterior ischemic optic neuropathy and invasive optic neuropathy. As with the left eye, steroid pulse therapy temporarily improved VA of the right eye and then decreased to 0.2. Additional anticoagulant therapy did not improve VA. Concurrent to therapy, the patient became febrile with depressed consciousness. Repeat MRI identified suspected midbrain infarction, and CSF examination indicated cerebral meningitis. In spite of administering transfusions and antibiotics, she died on hospital day 40. Autopsy revealed large amounts of Aspergillus hyphae mainly localized in the dura mater of the optic nerve and destruction of the cerebral artery wall, suggesting an etiology of subarachnoid hemorrhage. CONCLUSIONS: When examining refractory and persistent disc swelling, we should rule out fungal infections of the optic nerve.
    Jan. 2019, Case Reports in Ophthalmology, 10(1) (1), 11 - 18, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Masashi Kimura, Sentaro Kusuhara, Mizuki Tagami, Makoto Nakamura
    Jan. 2019, Case Reports in Ophthalmology, 10(1) (1), 5 - 10, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Atsuko Katsuyama, Sentaro Kusuhara, Ryuto Nishisho, Wataru Matsumiya, Atsushi Azumi, Makoto Nakamura
    Purpose: This study aimed to evaluate the long-term efficacy and safety of infliximab (IFX) and cyclosporine (CsA) combination therapy for refractory uveoretinitis in Behçet's disease (BD). Patients and methods: The study involved a retrospective review of the medical records of 11 patients with Behçet's uveoretinitis refractory to conventional treatment who had been treated with IFX+CsA combination therapy. The frequency of ocular inflammatory attacks and a Behçet's disease ocular attack score 24 (BOS24) were used as indices for the evaluation of efficacy during each 6-month period prior to and following initiation of therapy. For the assessment of safety, adverse events (AEs) were recorded throughout the treatment period. Results: The patients had received IFX+CsA combination therapy for 5.6±2.3 years. The frequency of ocular attacks per 6-month period decreased markedly from 2.9±1.6 during the baseline period to 0.6±0.9 during months 1-6, 0.5±0.9 during months 7-12, 0.3±0.5 during months 13-18, 0.3±0.7 during months 19-24, and 0.0±0.0 thereafter (P=0.003). The BOS24 score per ocular attack significantly decreased from 5.2±2.4 during the baseline period to 1.5±2.1 during months 1-6, 1.7±3.1 during months 7-12, 1.6±2.9 during months 13-18, and 0.4±1.0 during months 19-24 (P=0.002). No serious AEs were observed, with the exception of urinary tract infection and cataract progression. Two patients exhibited transient elevation of the serum creatinine level, which was normalized following a reduction in the dose of CsA. Conclusion: For refractory Behçet's uveoretinitis, IFX+CsA combination therapy offers a promising treatment option as it appears to have an acceptable safety profile and can reduce the frequency and severity of ocular inflammatory attacks over a long period of time.
    2019, Clinical ophthalmology (Auckland, N.Z.), 13, 521 - 527, English, International magazine
    [Refereed]
    Link to Kobe Univ. Repository (Kernel)

  • Takuji Kurimoto, Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yuko Yamada-Nakanishi, Wataru Matsumiya, Makoto Nakamura
    Background: Leber hereditary optic neuropathy (LHON) is a maternally inherited disease caused by three missense mutations of mitochondrial (mt) DNA, ie, m 3460 G>A, m 11778 G>A, or m 14484 T>C in the greater portion of LHON. m 11778 G>A mutation is especially observed in >90% of the cases in Japanese families. Although spontaneous remission of visual function infrequently occurs, effective treatment for LHON remains unestablished. Transcorneal electrical stimulation has been shown to be efficacious in individuals with optic neuropathy. However, due to potential risk of corneal damage, repeated treatments are not permissible. In this exploratory study, we will be conducting skin electrical stimulation (SES) as an intervention for patients with LHON having 11778 missense mutation and investigate effectiveness and safety of SES. Methods: This is a single-arm, prospective, open-label exploratory trial focused on patients with LHON having 11778 missense mutation. Eleven patients will be enrolled and receive six consecutive SES once every 2 weeks up to 10 weeks. The safety of the SES will be monitored with specular microscopy, slit-lamp biomicroscopy, fundus examinations, and the observation of facial skin. The primary outcome measure will be the averaged l ogarithm of minimum angle resolution (logMAR) converted visual acuity 1 week after the last SES. Secondary outcome measures include changes, in logMAR at 4 and 8 weeks after the last SES, such as visual field indices measured using Humphrey visual field and microperimetry-3, the thickness of peripapillary retinal fiber and macular ganglion cell complex, multifocal visual evoked potentials, critical flicker frequency, and color vision. Discussion: The results of this proposed proof-of-concept feasibility trial will help plan and execute a larger definitive trial to test SES as an effective strategy for LHON and related optic neuropathies and help establish a beneficial treatment for LHON.
    2019, Clinical ophthalmology (Auckland, N.Z.), 13, 897 - 904, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Akiko Miki, Yuko Yamada, Makoto Nakamura
    Purpose: To investigate the foveal avascular zone (FAZ) in the eyes of patients with a history of retinopathy of prematurity (ROP) using optical coherence tomography angiography (OCTA) and to identify associated clinical factors. Patients and methods: Overall, 14 children with a history of laser treatment for ROP, 17 children born prematurely without a history of ROP, and 41 age-matched children born at full-term (age range 7-14 years) were included. OCTA was conducted on an area measuring 3 × 3 mm in the central macula. The area of FAZ in the superficial layer was measured. Foveal thickness (FT), ganglion cell complex thickness, and the presence of inner retinal layer (IRL) at the fovea were evaluated. Results: There were significant differences in FT and FAZ size among patients (P < 0.001). The eyes of patients that had been treated for ROP showed the smallest FAZ and greatest FT. Univariate analyses demonstrated that the area of FAZ was not correlated with visual acuity (P=0.078) but with gestational age (GA) (P=0.001), birth weight (P=0.013), the presence of IRL (P < 0.001), and FT (P < 0.001). Multivariate regression analyses showed that the area of FAZ was significantly associated with GA, the presence of IRL, and FT (P=0.03, P=0.01, P < 0.001, respectively). Conclusion: The eyes of preterm children had small FAZ, and this reduction in area was associated with greater FT, the presence of IRL, and lower GA.
    2019, Journal of ophthalmology, 2019, 8340729 - 8340729, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Shunichiro Nakai, Wataru Matsumiya, Otsuka Keiko, Akiko Miki, Makoto Nakamura, Shigeru Honda
    PURPOSE: This study was prospectively carried out to clarify the effectiveness of visual and anatomical outcomes under combination therapy of intravitreal aflibercept (IVA) and verteporfin photodynamic therapy (vPDT) in over 24 months. STUDY DESIGN: A single-arm prospective exploratory study. METHODS: Twenty-six eyes of 26 treatment naïve PCV patients were enrolled in this study. The primary outcome measures were the changes in best corrected visual acuity (BCVA) and the complete polyp regression rate. The secondary outcome measures included central retinal thickness assessed by optical coherence tomography. RESULTS: The patients showed significant improvement in BCVA by 0.14 logMAR units at 12 months and 0.11 logMAR units at 24 months from baseline (both p < 0.01). The mean central retinal thickness also significantly decreased at 12 months (p < 0.001) and at 24 months (p = 0.001). Complete regression of polypoidal lesions was achieved by 15 out of 20 eyes (75%) at 12 months and 11 out of 20 eyes (55%) at 24 months. The mean treatment number was 2.9 courses of IVA and 1.5 courses of vPDT and the mean retreatment free interval after initial therapy was 12.8 months during follow up of 24 months. The complete data from all predetermined examinations were observed in 17 out of 26 enrolled patients (65%) in this study. CONCLUSION: In this study, combination therapy of IVA and vPDT yielded visual and anatomical improvements in treatment-naïve PCV patients over a 24-month follow-up period.
    Jan. 2019, Japanese journal of ophthalmology, 63(1) (1), 100 - 108, English, Domestic magazine
    [Refereed]
    Scientific journal

  • 盛 崇太朗, 栗本 拓治, 荒木 健, 坂本 麻里, 上田 香織, 大塚 喜久, 芥子 結香子, 佐竹 渉, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 79 - 79, Japanese

  • 抗血管内皮増殖因子薬硝子体内注射で治療開始した網膜静脈分枝閉塞症の治療休止割合
    勝山 敦子, 楠原 仙太郎, 松宮 亘, 三木 明子, 今井 尚徳, 本田 茂, 中村 誠
    眼科臨床紀要会, Nov. 2018, 眼科臨床紀要, 11(11) (11), 838 - 839, Japanese
    [Refereed]

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の1例
    佐々木 信之, 坂本 麻里, 栗本 拓治, 盛 崇太郎, 上田 香織, 中西 裕子, 飯島 健太, 立花 久嗣, 中村 誠
    日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 87 - 87, Japanese
    [Refereed]

  • 糖尿病黄斑浮腫治療成績とOCT en face slab像の関係
    楠原 仙太郎, 勝山 敦子, 松宮 亘, 中村 誠
    (一社)日本糖尿病合併症学会, Oct. 2018, 糖尿病合併症, 32(Suppl.1) (Suppl.1), 298 - 298, Japanese
    [Refereed]

  • 視力良好なポリープ状脈絡膜血管症への光線力学的療法単独とアフリベルセプト併用療法
    松宮 亘, 本田 茂, 中井 駿一朗, 勝山 敦子, 大塚 慶子, 三木 明子, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Oct. 2018, 眼科臨床紀要, 11(10) (10), 763 - 763, Japanese
    [Refereed]

  • Mori S, Sakamoto M, Kurimoto T, Kanamori A, Ueda K, Inoue Y, Yamada Yuko, Nakamura Makoto
    PURPOSE: The purpose of this study was to evaluate the surgical success of sulcus fixation of Baerveldt glaucoma implant (BGIs) in special reference to corneal damage. METHODS: This observational prospective cohort study included 24 patients who underwent a median of 3.0 previous intraocular surgeries and sulcus fixation of BGIs for the first time. The intraocular pressure (IOP), the number of ocular hypotensives used, corneal endothelial cell density (ECD), and logMAR-converted best-corrected visual acuity (VA) of each patient were measured preoperatively and postoperatively until 12 months after surgery. Surgical success was evaluated after 12 months based on the reduction of IOP (5-21 mmHg and > 20% reduction), corneal damage (postoperative development of decompensation, unmeasurable ECD, or ECD reduction of > 20%), loss of light perception, and need for additional surgeries. RESULTS: Surgical success was noted in 16 (66.7%) patients when corneal damage was included as a failure criterion, whereas surgery was successful in 21 (87.5%) patients when solely judged using IOP control similarly as previous clinical trials. The median IOP decreased from 27.5 mmHg preoperatively to 14.5 mmHg postoperatively (P < 0.0001). The number of ocular hypotensives was significantly reduced postoperatively (P < 0.0001). The median postoperative ECD reduction was only 0.15%, although ECD could not be measured during follow-up or it was significantly reduced by > 20% in six patients. VA was not significantly reduced after surgery. Adverse effects were observed in 15 patients (62.5 cumulative %). CONCLUSION: Sulcus fixation of BGIs may be effective and safe in patients with glaucomatous eyes who underwent multiple prior intraocular surgeries.
    Oct. 2018, Graefes Arch Clin Exp Ophthalmol, 256(10) (10), 1953 - 1960, English, International magazine
    [Refereed]
    Scientific journal

  • 実臨床における糖尿病黄斑浮腫に対するラニビズマブ硝子体注射の12ヵ月治療成績
    楠原 仙太郎, 勝山 敦子, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    日本糖尿病眼学会, Sep. 2018, 日本糖尿病眼学会誌, 22, 134 - 134, Japanese
    [Refereed]

  • Akiko Miki, Masashi Fujihara, Akiko Yoshida, Makoto Nakamura, Atsushi Azumi
    Purpose: To report a rare case of bilateral periphlebitis associated with a pineal germinoma. Observations: A 17-year-old male teenager presented at a local clinic complaining of blurred vision in both eyes. The treating physician identified bilateral uveitis, and prescribed the patient with a local steroid treatment. However, the inflammatory findings did not improve with the treatment, and the patient was referred to our hospital for further examination. At the first visit, his best-corrected visual acuities were 0.3 for the right eye and 0.06 for the left eye; we found no inflammation in the anterior ocular segment, but observed bilateral retinal periphlebitis and a proliferative membrane from the papilla to the macula in the ocular fundus. In addition, we found a tractional serous retinal detachment in the macula. We suspected tuberculous uveitis clinically and initiated treatment with an antituberculous drug. However, the condition of the patient did not improve. Two months after our initial examination, left optic neuritis appeared, and we initiated a steroid pulse therapy. Although the periphlebitis remained, the left optic nerve findings and the visual acuity of both eyes improved. Thus, we reduced the oral steroid dose gradually. However, two months after initiating the dose reduction, the patient suffered a consciousness disturbance, and we detected a pineal tumor by magnetic resonance imaging (MRI). The patient was diagnosed as having a germ cell tumor by pathological examination and underwent radiation and chemotherapy. We noted marked improvements in both the periphlebitis findings and in the visual acuity following the treatment for the pineal tumor. Conclusions and importance: Cases of pineal tumor accompanied with retinal periphlebitis have been reported rarely. Because juvenile retinal vasculitis cases of unknown cause can be associated with pineal germinomas, we recommend brain MRI examinations for such cases.
    Sep. 2018, American journal of ophthalmology case reports, 11, 142 - 145, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • レーベル遺伝性視神経症における視標サイズに基づく中心暗点の評価
    Ueda Kaori, 盛崇太朗, 坂本麻里, 芥子結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto
    Sep. 2018, 神経眼科, 35(3号) (3号), 303 - 308, Japanese
    [Refereed]
    Scientific journal

  • Sakamoto M, Kurimoto T, Mori S, Ueda Kaori, Keshi Y, Yamada Yuko, Azumi A, Shimono T, Nakamura Makoto
    PURPOSE: To present a unique case of neuro-neutrophilic disease with inflammation and thrombosis of the superior ophthalmic vein (SOV). OBSERVATIONS: A 43-year-old Japanese man with past histories of oculomotor paralysis, auditory disorder, ischemic enteritis, and recurrent oral ulceration was referred to our hospital because of blurred vision in his right eye. Ophthalmic examination revealed decreased best corrected visual acuity and central scotoma in his right eye. Orbit magnetic resonance imaging (MRI) revealed an enlarged SOV in the right eye, with Gadolinium (Gd) enhancement in the wall of the vein but not inside the vein, indicating thrombosis. Multiple Gd-enhanced hyperintense lesions were also observed in the juxtacortical area of the brain. We diagnosed the patient with vasculitis in the right SOV that was adversely affecting the optic nerve. We ruled out systemic thrombophilia, infections, and malignancy by systemic examinations. The human leukocyte antigen (HLA) typing was Cw1-, B54-, B61-, A2-, A24-, and DR4-positive and B51-negative. We treated the patient with systemic steroid and anticoagulant therapy. After three courses of steroid pulse therapy, his symptoms and the MRI findings of the right SOV and brain improved; therefore, we decided to discontinue the anticoagulant therapy. One month after anticoagulant cessation, MRI revealed recurrence of the thrombus and enlargement of the right SOV despite the lack of vision worsening. We restarted the anticoagulant therapy while continuing the oral prednisolone treatment. At the final visit, 14 months after the onset of the disease, the patient was still receiving oral anticoagulation with warfarin potassium and prednisolone (5 mg/day). His symptoms and the right eye's visual function remained normal with a mildly enlarged SOV; there was less Gd enhancement and no brain lesions on MRI. CONCLUSIONS AND IMPORTANCE: We treated a unique case of possible neuro-neutrophilic disease that presented visual disturbances due to right SOV inflammation and thrombosis. Anticoagulation and systemic steroid therapies were required to reduce the inflammation and to prevent the recurrence of thrombosis.
    Aug. 2018, Am J Ophthalmol Case Rep, 12, 39 - 44, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 緑内障眼における他覚的・自覚的機能検査結果とEn Face slab画像を用いた構造評価結果の相関性の検討
    井上 結香子, 鎌田 誠子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 山田 裕子, 中村 誠
    眼科臨床紀要会, Jul. 2018, 眼科臨床紀要, 11(7) (7), 555 - 555, Japanese

  • Sotaro Mori, Takuji Kurimoto, Kaori Ueda, Makoto Nakamura
    Springer Tokyo, Jul. 2018, Japanese Journal of Ophthalmology, 62(4) (4), 525 - 530, English
    [Refereed]
    Scientific journal

  • The association of age-related maculopathy susceptibility 2 gene polymorphisms with the 12 months outcomes of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy for polypoidal choroidal vasculopathy
    Nakai Shunichiro, Honda Shigeru, Matsumiya Wataru, Miki Akiko, Nakamura Makoto
    Jul. 2018, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9) (9)
    [Refereed]
    Scientific journal

  • Structural changes in the inner retina assessed by slab en face optical coherence tomography in diabetic eyes
    Katsuyama Atsuko, Kusuhara Sentaro, Matsumiya Wataru, Honda Shigeru, Nakamura Makoto
    Jul. 2018, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 59(9) (9)
    [Refereed]
    Scientific journal

  • Mori S, Kurimoto T, Ueda Kaori, Enomoto H, Sakamoto M, Keshi Y, Yamada Yuko, Nakamura Makoto
    BACKGROUND: Recent immune therapy with checkpoint inhibitors (CPIs) has demonstrated remarkable antitumor effects on specific tumors, such as malignant lymphoma and non-small cell lung carcinoma. By contrast, CPIs cause an imbalance in the immune system, triggering a wide range of immunological side effects termed immune-related adverse effects (irAEs). Here, we report a rare case of optic neuritis and hypopituitarism during anti-programmed death-ligand 1 (PD-L1) antibody treatment. CASE PRESENTATION: A patient with non-small cell lung carcinoma received anti-PD-L1 antibody treatment every 3 weeks; however, the patient started experiencing headaches, general fatigue, anorexia, and diarrhea approximately 1 year after the initiation of the treatment. Moreover, sudden visual loss of the right eye occurred 1 week after the interruption of the anti-PD-L1 antibody treatment. MRI findings showed gadolinium enhancement in the left optic nerve, but no enlargement of the pituitary gland and stalk. Laboratory data showed decreased serum adrenocorticotropic hormone (ACTH), cortisol, and free T4 levels, and a hormone tolerance test indicated hypopituitarism, hypothyroidism, and hypoadrenocorticism. The central scotoma caused by optic neuritis completely disappeared immediately after a course of steroid pulse therapy, and no recurrence occurred up to 2 years after initiation of the steroid pulse therapy while replacement therapy for hypothyroidism and hypoadrenocorticism was continued. CONCLUSIONS: The patient presented with optic neuritis and hypopituitarism, possibly due to irAEs of the anti-PD-L1 antibody treatment. Steroid pulse therapy was effective for optic neuritis, suggesting underlying immunological mechanisms. Neurological complications including optic neuritis should be considered when examining patients with cancer undergoing CPI treatment.
    Jul. 2018, Case Rep Ophthalmol, 9(2) (2), 348 - 356, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoshikatsu Hosoda, Munemitsu Yoshikawa, Masahiro Miyake, Yasuharu Tabara, Jeeyun Ahn, Se Joon Woo, Shigeru Honda, Yoichi Sakurada, Chieko Shiragami, Hideo Nakanishi, Akio Oishi, Sotaro Ooto, Akiko Miki, Tomohiro Iida, Hiroyuki Iijima, Makoto Nakamura, Chiea Chuen Khor, Tien Yin Wong, Kyuyoung Song, Kyu Hyung Park, Ryo Yamada, Fumihiko Matsuda, Akitaka Tsujikawa, Kenji Yamashiro
    Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed a characteristic increase of choroidal thickness in CSC, we conducted a genome-wide association study on choroidal thickness in 3,418 individuals followed by TaqMan assays in 2,692 subjects, and we identified two susceptibility loci: CFH rs800292, an established AMD susceptibility polymorphism, and VIPR2 rs3793217 (P = 2.05 × 10-10 and 6.75 × 10-8, respectively). Case-control studies using patients with CSC confirmed associations between both polymorphisms and CSC (P = 5.27 × 10-5 and 5.14 × 10-5, respectively). The CFH rs800292 G allele is reportedly a risk allele for AMD, whereas the A allele conferred risk for thicker choroid and CSC development. This study not only shows that susceptibility genes for CSC could be discovered using choroidal thickness as a defining variable but also, deepens the understanding of differences between CSC and AMD pathophysiology.
    Jun. 2018, Proceedings of the National Academy of Sciences of the United States of America, 115(24) (24), 6261 - 6266, English, International magazine
    [Refereed]
    Scientific journal

  • Satsuki Obata, Akiko Miki, Hisanori Imai, Makoto Nakamura
    Purpose: To report a case of temporary bilateral corneal denting in a patient who underwent cardiovascular surgery under general anesthesia. Observations: A 71-year-old male with no history of ophthalmological disease experienced bilateral corneal denting immediately after undergoing surgery for aneurysm of the thoracic aorta under general anesthesia. Anesthesia was induced with propofol and maintained with rocuronium bromide and remifentanil hydrochloride. The initial examination revealed significant denting on the surface of both the corneas and ocular hypotension. Visual evaluation could not be performed due to the patient's low level of consciousness resulting from delayed emergence from anesthesia. After applying tropicamide and phenylephrine ophthalmic solution for fundus examination, the ocular morphology improved. Ocular pressure was normal on the day after surgery, and creasing on the surface of the corneas had disappeared. Conclusions: and Importance: We experienced a patient with bilateral corneal denting following a cardiovascular surgery under general anesthesia. The dents could be attributed to augmentation of ocular hypotension using several types of anesthesia at relatively high doses.
    Jun. 2018, American journal of ophthalmology case reports, 10, 290 - 292, English, International magazine
    [Refereed]
    Link to Kobe Univ. Repository (Kernel)

  • Sentaro Kusuhara, Atsuko Katsuyama, Wataru Matsumiya, Makoto Nakamura
    PURPOSE: The purpose of this study was to describe the initial experience, efficacy, and safety of ripasudil hydrochloride hydrate (ripasudil), a Rho-associated kinase inhibitor eye drop, for uveitic glaucoma. METHODS: In this retrospective case series, we retrieved the clinical data of 21 eyes from 19 patients with open-angle uveitic glaucoma who were treated with ripasudil at Kobe University Hospital. We analyzed the median intraocular pressure (IOP) reductions after ripasudil treatment and collected the information on the adverse events that were encountered during the course of this treatment period. RESULTS: The causes of uveitis were sarcoidosis (29%), Behçet's disease (14%), Vogt-Koyanagi-Harada disease (10%), others (15%), and unclassified (33%). Of total, 19 (90%) eyes were treated with topical, periocular, and/or systemic steroid therapies. The median number of glaucoma medications used before ripasudil treatment was 2, and the median follow-up time was 13 months. The median IOPs were 23 mmHg at baseline, 16 mmHg at 1 month, and 18 mmHg at 12 months with significant IOP reductions of - 3 mmHg at 1 month and - 2 mmHg at 12 months (P = 0.0050). Of total, 11 (52%) eyes with an IOP reduction ≥ 3 mmHg at 1 month (responders) showed a significant median IOP decrease at 12 months compared with non-responders (- 5 versus 0 mmHg, P = 0.0242). Two adverse events were observed: rashes on the back and transient conjunctival hyperemia. CONCLUSIONS: Ripasudil appears to be safe and substantially reduce IOP in eyes with uveitic glaucoma if the eye is a responder. Ripasudil could be an option for the treatment of uveitic glaucoma.
    Apr. 2018, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(4) (4), 809 - 814, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 緑内障眼における他覚的・自覚的機能検査結果とen face slab画像を用いた構造評価結果の相関性の検討
    井上 結香子, 鎌田 誠子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(3) (3), 252 - 253, Japanese

  • アクアポリン9遺伝子欠損マウスにおける視神経挫滅後の網膜神経節細胞死
    盛 崇太朗, 栗本 拓治, 三木 明子, 楠原 仙太郎, 金森 章泰, 中村 誠
    (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 166 - 166, Japanese
    [Refereed]

  • 光干渉断層計slab en face像を用いた糖尿病網膜内層構造変化の評価
    勝山 敦子, 楠原 仙太郎, 松宮 亘, 本田 茂, 中村 誠
    (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 176 - 176, Japanese
    [Refereed]

  • ポリープ状脈絡膜血管症へのアフリベルセプト併用光線力学療法後の網膜色素上皮萎縮
    松宮 亘, 本田 茂, 林田 真由香, 中井 駿一朗, 勝山 敦子, 大塚 慶子, 三木 明子, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 203 - 203, Japanese
    [Refereed]

  • 続発緑内障に対するテノン開創器を用いた線維柱帯切除術の短期成績
    楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2018, 日本眼科学会雑誌, 122(臨増) (臨増), 246 - 246, Japanese
    [Refereed]

  • 研究代表者, 所属機関, 石川 均, 医療衛生学部リハビリテーション学科視覚機能療法学専, 研究分担者, 三村 治, 兵, 神経眼科治療学, 吉冨 健志, 大学院医療系研究科医学専攻病態制御医学系眼科学講座, 敷島 敬悟, 眼科, 平岡 美紀, 学, 眼科, 中馬 秀樹, 医学部感覚運動医学講座眼科学分野, 毛塚 剛司, 医学部医学科, 中村 誠, 大学院医学研究科, 後関 利明, 田中 惠子, 脳研究所細胞神経, 研究協力者, 山上明子, 医療法人社団, 済安堂, 井上眼科病院, 星佳芳(北里大学医学部衛生学, 真下紀美代, 学医学部, 伊藤光, 北里大学医療衛生
    Mar. 2018, 平成27(2015)年度～ 平成29(2017)年度 厚生労働科学研究費補助金 疾病・障害対策研究分野 難治性疾患等政策研究（難治性疾患政策研究）総括研究報告書, Japanese
    Research society

  • Keiko Otsuka, Hisanori Imai, Akiko Miki, Makoto Nakamura
    PURPOSE: To compare the postoperative anatomic success rates and the frequency of complications between prone or supine postoperative positioning after transconjunctival sutureless vitrectomy (TSV) for rhegmatogenous retinal detachment (RRD). METHODS: All patients underwent primary 27-gauge TSV for the treatment of primary RRD. Patients were divided into two groups as follows: group A was patients instructed to keep strict postoperative prone positioning for a minimum of 8 days. Group B was patients instructed to keep the prone positioning on the day of the surgery followed by supine positioning for minimum of 7 days from the day after surgery. RESULT: Sixty-two eyes were enrolled (group A: 32, group B: 30). There was no significant difference in baseline data between two groups. The initial and final anatomical success rates were 93.8% and 100% in group A and 93.3% and 100% in group B, respectively (p = 1, p = 1, respectively). Posterior synechia of the iris occurred in one eye in group A and in two eyes in group B (p = 0.61). Macular pucker and retinal fold did not occur in either group. Preoperative intraocular pressure (IOP; mmHg) was 14.5 ± 2.9 in group A and 14.5 ± 2.6 in group B (p = 0.92). Intraocular pressure (IOP) was not statistically different between the groups during the follow-up period (p = 0.36, p = 0.07, respectively). CONCLUSION: Supine positioning may be an option as a postoperative positioning after TSV and gas tamponade for the treatment of RRD.
    Mar. 2018, Acta ophthalmologica, 96(2) (2), e189-e194 - e194, English, International magazine
    [Refereed]
    Scientific journal

  • ShigaY, AkiyamaM, NishiguchiKM, SatoK, ShimozawaN, TakahashiA, MomozawaY, HirataM, MatsudaK, YamajiT, IwasakiM, TsuganeS, OzeI, MikamiH, NaitoM, WakaiK, YoshikawaM, MiyakeM, YamashiroK, JapanGlaucomaSocietyOmicsGroup(JGS-OG, Kashiwagi K, Iwata T, Mabuchi F, Takamoto M, Ozaki M, Kawase K, Aihara M, Araie M, Yamamoto T, Kiuchi Y, Nakamura Makoto, Ikeda Y, Sonoda KH, Ishibashi T, Nitta K, Iwase A, Shirato S, Oka Y, Satoh M, Sasaki M, Fuse N, Suzuki Y, Cheng CY, Khor CC, Baskaran M, Perera S, Aung T, Vithana EN, Cooke Bailey JN, Kang JH, Pasquale LR, Haines JL, NEIGHBORHOOD Consortium, Wiggs JL, Burdon KP, Gharahkhani P, Hewitt AW, Mackey DA, MacGregor S, Craig JE, Allingham RR, Hauser M, Ashaye A, Budenz DL, Akafo S, Williams SEI, Kamatani Y, Nakazawa T, Kubo M
    Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide for which 15 disease-associated loci had been discovered. Among them, only 5 loci have been associated with POAG in Asians. We carried out a genome-wide association study and a replication study that included a total of 7378 POAG cases and 36 385 controls from a Japanese population. After combining the genome-wide association study and the two replication sets, we identified 11 POAG-associated loci, including 4 known (CDKN2B-AS1, ABCA1, SIX6 and AFAP1) and 7 novel loci (FNDC3B, ANKRD55-MAP3K1, LMX1B, LHPP, HMGA2, MEIS2 and LOXL1) at a genome-wide significance level (P < 5.0×10-8), bringing the total number of POAG-susceptibility loci to 22. The 7 novel variants were subsequently evaluated in a multiethnic population comprising non-Japanese East Asians (1008 cases, 591 controls), Europeans (5008 cases, 35 472 controls) and Africans (2341 cases, 2037 controls). The candidate genes located within the new loci were related to ocular development (LMX1B, HMGA2 and MAP3K1) and glaucoma-related phenotypes (FNDC3B, LMX1B and LOXL1). Pathway analysis suggested epidermal growth factor receptor signaling might be involved in POAG pathogenesis. Genetic correlation analysis revealed the relationships between POAG and systemic diseases, including type 2 diabetes and cardiovascular diseases. These results improve our understanding of the genetic factors that affect the risk of developing POAG and provide new insight into the genetic architecture of POAG in Asians.
    Feb. 2018, Hum Mol Genet, 27(8) (8), 1486 - 1496, English, International magazine
    [Refereed]
    Scientific journal

  • Yumiko Nakano, Akiko Miki, Shigeru Honda, Makoto Nakamura
    S. Karger AG, Jan. 2018, Case Reports in Ophthalmology, 9(1) (1), 92 - 95, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Kaori Ueda, Akishi Onishi, Shin-ichiro Ito, Makoto Nakamura, Masayo Takahashi
    Elsevier B.V., Jan. 2018, Biochemical and Biophysical Research Communications, 495(4) (4), 2595 - 2601, English
    [Refereed]
    Scientific journal

  • Kaori Ueda, Sotaro Mori, Mari Sakamoto, Yukako Keshi, Takuji Kurimoto, Yuko Yamada, Makoto Nakamura
    Neuro-Ophthalmology Society of Japan, 2018, Neuro-Ophthalmology Japan, 35(3) (3), 303 - 308, Japanese
    Scientific journal

  • Akiko Miki, Shigeru Honda, Yukako Inoue, Yuko Yamada, Makoto Nakamura
    PURPOSE: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). METHODS: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. RESULTS: The ROP group demonstrated the worst VA and the shallowest foveal depression. Furthermore, foveal depression significantly correlated with birth weight, GA, ganglion cell layer/inner plexiform layer (GCL-IPL) thickness, and a history of ROP. CONCLUSIONS: This study established a correlation of fovea formation with premature birth, damage of GCL-IPL, and a history of ROP. The retention of the inner retina possibly contributes to abnormal foveal morphology in patients with a history of ROP.
    2018, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 240(2) (2), 106 - 110, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mari Sakamoto, Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
    Public Library of Science, Jan. 2018, PLoS ONE, 13(1) (1), e0191862, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Mari Sakamoto, Sotaro Mori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
    Springer Tokyo, Jan. 2018, Japanese Journal of Ophthalmology, 62(1) (1), 31 - 40, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Keiko Otsuka, Hisanori Imai, Ayaka Fujii, Akiko Miki, Mizuki Tagami, Atsushi Azumi, Makoto Nakamura
    Aim: To compare the anatomic and visual outcomes of 25-gauge (25G), and 27-gauge (27G) transconjunctival sutureless pars plana vitrectomy (TSV) for the management of primary rhegmatogeneous retinal detachment (RRD). Design: A retrospective nonrandomized clinical trial. Methods: A retrospective comparative analysis of 62 consecutive eyes from 62 patients with 6 months of follow-up was performed. Results: Thirty-two patients underwent 25G TSV, and 30 patients underwent 27G TSV for the treatment of primary RRD. There was no significant difference in baseline demographic and preoperative ocular characteristics between the two groups. The initial and final anatomical success rates were 93.8% and 100% in 25G TSV and 96.7% and 100% in 27G TSV, respectively (p=1 and p=1, resp.). Preoperative best-corrected visual acuity (BCVA) (logMAR) was 0.44 ± 0.69 and 0.38 ± 0.61 for 25G and 27G TSV, respectively (p=0.73). The final follow-up BCVA was 0.07 ± 0.25 and -0.02 ± 0.17 for 25G and 27G TSV, respectively (p=0.16). The final BCVA was significantly better than the preoperative BCVA in both groups (p=0.02 and p=0.002, resp.). Preoperative intraocular pressure (IOP) (mmHg) was 13.0 ± 3.5 in 25G TSV and 14.3 ± 2.8 in 27G TSV (p=0.11). IOP did not statistically significantly change in both groups during the follow-up period (p=0.63 and p=0.21, resp.). Conclusion: The 27G TSV system is safe and useful for RRD treatment as 25G TSV.
    2018, Journal of ophthalmology, 2018, 7643174 - 7643174, English, International magazine
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 視神経鞘髄膜腫に対し強度変調放射線治療を施行した神経線維腫症2型の一例
    松野裕樹, Yamada Yuko, 井上結香子, 金森章泰, Nakamura Makoto
    Dec. 2017, 神経眼科, 34(4号) (4号), 449 - 454, Japanese
    [Refereed]
    Scientific journal

  • 2.0mm極小切開白内障手術における術創作成方法の違いによる術創健常性の比較検討 経結膜強角膜一面切開vs角膜切開
    大塚慶子, 今井尚徳, Nakamura Makoto
    (株)杏林舎内「IOL&RS」編集事務局, Dec. 2017, IOL & RS, 31(4号) (4号), 617 - 622, Japanese
    [Refereed]
    Scientific journal

  • 強度近視に伴う分層黄斑円孔に対する翻転法の有無での硝子体手術成績の検討
    大塚 慶子, 今井 尚徳, 中村 誠
    眼科臨床紀要会, Nov. 2017, 眼科臨床紀要, 10(11) (11), 946 - 947, Japanese

  • 網膜前膜術後の最高矯正視力予測因子の検討
    中村 賢和, 今井 尚徳, 勝山 敦子, 中井 駿一朗, 大塚 慶子, 三木 明子, 長井 隆行, 楠原 仙太郎, 本田 茂, 中村 誠
    眼科臨床紀要会, Nov. 2017, 眼科臨床紀要, 10(11) (11), 932 - 932, Japanese
    [Refereed]

  • ポリープ状脈絡膜血管症に対する光線力学療法3年予後に関連する遺伝子多型の検討
    中井 駿一朗, 本田 茂, 勝山 敦子, 大塚 慶子, 三木 明子, 近藤 陽子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2017, 眼科臨床紀要, 10(11) (11), 941 - 941, Japanese
    [Refereed]

  • アキシチニブ内服中に著しい網膜循環障害をきたした1例
    木村 将, 楠原 仙太郎, 田上 瑞記, 本田 茂, 中村 誠
    眼科臨床紀要会, Nov. 2017, 眼科臨床紀要, 10(11) (11), 950 - 950, Japanese
    [Refereed]

  • Photodynamic therapy and intravitreal bevacizumab resulted in prolonged improvement of visual acuity in a case of choroidal osteoma with choroidal neovascularization
    Hiroko Enomoto, Shigeru Honda, Akiko Miki, Keiko Otsuka, Shunichiro Nakai, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    Igaku-Shoin Ltd, Oct. 2017, Japanese Journal of Clinical Ophthalmology, 71(10) (10), 1505 - 1511, Japanese
    Scientific journal

  • 盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 山田 裕子, 中村 誠
    日本神経眼科学会, Oct. 2017, 神経眼科, 34(増補1) (増補1), 66 - 66, Japanese

  • 上田 香織, 盛 崇太朗, 坂本 麻里, 井上 結香子, 栗本 拓治, 山田 裕子, 中村 誠
    日本神経眼科学会, Oct. 2017, 神経眼科, 34(増補1) (増補1), 75 - 75, Japanese

  • 崔 龍東, 栗本 拓治, 盛 崇太朗, 坂本 麻里, 上田 香織, 井上 結香子, 山田 裕子, 中村 誠
    日本神経眼科学会, Oct. 2017, 神経眼科, 34(増補1) (増補1), 106 - 106, Japanese

  • 坂本 麻里, 盛 崇太朗, 上田 香織, 井上 結香子, 栗本 拓治, 山田 裕子, 中村 誠
    日本神経眼科学会, Oct. 2017, 神経眼科, 34(増補1) (増補1), 110 - 110, Japanese

  • 難治性視神経炎全国調査 2017年度結果報告
    石川 均, 毛塚 剛司, 後関 利明, 三村 治, 吉冨 健志, 敷島 敬悟, 平岡 美紀, 中馬 秀樹, 中村 誠, 山上 明子, 田中 惠子
    日本神経眼科学会, Oct. 2017, 神経眼科, 34(増補1) (増補1), 72 - 72, Japanese
    [Refereed]

  • 網膜静脈分枝閉塞症に対するラニビズマブ硝子体注射12ヵ月後視力予後因子の検討
    勝山 敦子, 楠原 仙太郎, 中井 駿一朗, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    眼科臨床紀要会, Oct. 2017, 眼科臨床紀要, 10(10) (10), 856 - 857, Japanese
    [Refereed]

  • 糖尿病性黄斑浮腫に対するアフリベルセプト治療に影響する因子についての検討
    宮本 紀子, 楠原 仙太郎, 岩見 久司, 山本 庄吾, 吉水 聡, 吉武 信, 石田 和寛, 廣田 勇士, 本田 茂, 中村 誠, 池田 誠宏, 五味 文, 栗本 康夫
    (一社)日本糖尿病合併症学会, Oct. 2017, 糖尿病合併症, 31(Suppl.1) (Suppl.1), 349 - 349, Japanese
    [Refereed]

  • 実臨床における糖尿病黄斑浮腫に対する抗VEGF薬硝子体注射の12ヵ月治療成績
    楠原 仙太郎, 勝山 敦子, 大塚 慶子, 松宮 亘, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    (一社)日本糖尿病合併症学会, Oct. 2017, 糖尿病合併症, 31(Suppl.1) (Suppl.1), 350 - 350, Japanese
    [Refereed]

  • 臨床報告 光線力学療法とベバシズマブ硝子体注射により長期間視力が改善した脈絡膜骨腫に続発した脈絡膜血管新生の1例
    榎本寛子, 本田茂, 三木明子, 大塚慶子, 中井駿一朗, 今井尚徳, 楠原仙太郎, Nakamura Makoto
    (株)医学書院, Oct. 2017, 臨床眼科, 71(10) (10), 1505 - 1511, Japanese
    [Refereed]
    Scientific journal

  • Kaori Ueda, Yuki Morizane, Fumio Shiraga, Keigo Shikishima, Hitoshi Ishikawa, Masato Wakakura, Makoto Nakamura
    Sep. 2017, JOURNAL OF EPIDEMIOLOGY, 27(9) (9), 447 - 450, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 毛塚 剛司, 石川 均, 後関 利明, 敷島 敬悟, 山上 明子, 三村 治, 吉富 健志, 平岡 美紀, 中馬 秀樹, 中村 誠, 田中 惠子
    (一社)日本臨床免疫学会, Aug. 2017, 日本臨床免疫学会会誌, 40(4) (4), 260 - 260, Japanese

  • Shigeru Honda, Akiko Miki, Sentaro Kusuhara, Hisanori Imai, Makoto Nakamura
    PURPOSE: Central serous chorioretinopathy (CSC) is a common choroidal disorder which often affects the vision of young adults. Although the molecular mechanisms associated with CSC remain unknown, correlations between steroid hormone use and CSC have been suspected. We investigated the choroidal status of CSC secondary to corticosteroid use. METHODS: The records of 25 eyes of 25 consecutive acute CSC cases secondary to corticosteroid use were reviewed retrospectively. Central choroidal thickness was measured by optical coherent tomography. Choroidal vessel dilation and choroidal vascular hyperpermeability were evaluated based on indocyanine green angiography findings. The parameters related to secondary CSC were compared with those of 25 eyes of 25 cases with acute idiopathic CSC. RESULTS: The mean central choroidal thickness of secondary CSC was 294.8 ± 95.0 μm, which was significantly thinner than that of idiopathic CSC (409.4 ± 124.7 μm, P = 0.00064). The proportion of the cases exhibiting choroidal vessel dilation was not significantly different between secondary CSC (52%) and idiopathic CSC (64%). The proportion of cases showing choroidal vascular hyperpermeability was significantly smaller in secondary CSC (62%) than idiopathic CSC (92%) (P = 0.028). CONCLUSION: The choroidal status in the acute phase of secondary CSC after corticosteroid use might be different from that of idiopathic CSC, which suggests a complex mechanism for CSC.
    Aug. 2017, Retina (Philadelphia, Pa.), 37(8) (8), 1562 - 1567, English, International magazine
    [Refereed]
    Scientific journal

  • 下垂体腫瘍患者における光干渉断層計と静的視野検査および多局所視覚誘発電位の異常検出の一致性
    井上 結香子, 盛 崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 金森 章泰, 山田 裕子, 中村 誠
    眼科臨床紀要会, Jul. 2017, 眼科臨床紀要, 10(7) (7), 585 - 586, Japanese

  • ARMS2 variants may predict the 3-year outcome of photodynamic therapy for wet age-related macular degeneration
    Shunichiro Nakai, Shigeru Honda, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
    Jul. 2017, MOLECULAR VISION, 23, 514 - 519, English
    [Refereed]
    Scientific journal

  • Association between CFH variants and choroidal thickness in central serous chorioretinopathy
    Miki Akiko, Honda Shigeru, Sakurada Yoichi, Tanaka Kohji, Mitamura Yoshinori, Nakamura Makoto
    Jun. 2017, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58(8) (8)
    [Refereed]
    Scientific journal

  • Case Report : A Case of Acquired Peripheral Retinoschisis with Retinal Detachment in Young Adult
    Honda S, Nakamura Y, Nakamura M
    日本眼科学会, May 2017, Nippon Ganka Gakkai zasshi, 121(5) (5), 431 - 5, Japanese
    [Refereed]
    Scientific journal

  • 若年成人にみられた続発性網膜剥離を伴う後天性周辺部網膜分離症の1例
    Honda Shigeru, 中村賢和, Nakamura Makoto
    日本眼科学会, May 2017, 日本眼科学会雑誌, 121(5号) (5号), 431 - 435, Japanese
    [Refereed]
    Scientific journal

  • [Home Monitoring of Intraocular Pressure and it's Diurnal Patterns Using Icare® HOME].
    Mari Sakamoto, Akiyasu Kanamori, Sotaro Mori, Kaori Ueda, Yukako Inoue, Takuji Kurimoto, Yuko Yamada, Makoto Nakamura
    Purpose: To evaluate Icare® HOME for home monitoring of intraocular pressure (IOP) and to observe diurnal IOP patterns for a short term. Patients and methods: Twenty six eyes of 16 patients with open angle glaucoma were included. After instruction and practice in using Icare® HOME, patients were asked to measure their IOP by themselves at home or in a sick room. Patients measured their IOP four times a day with a four hour interval between each measurement for three days. Patients repeated measurements until three successful measurements were obtained at each time. Intra-rater reliability was assessed calculating intraclass correlation coefficient (ICC) of the three measurements. Diurnal IOP patterns were assessed for three days. Results: No adverse events occurred. ICC of three measurements was 0.76 (95% confidence coefficient; 0.71 to 0.81). The median of the difference between the highest and the lowest IOP during a day was 4.26 mmHg (95% CI; 4.06 to 4.67). Repeatable patterns were not found in diurnal IOP for three days. Three out of ten patients who answered the questionnaire after measurements found difficulties in handling the device. Conclusions: Although Icare® HOME is safe and could be used for home monitoring of IOP, some patients had difficulties in using the instrument. Diurnal IOP patterns did not show repeatability during a short term.
    Apr. 2017, Nippon Ganka Gakkai zasshi, 121(4) (4), 366 - 72, Japanese, Domestic magazine
    Scientific journal

  • 糖尿病黄斑浮腫に対するラニビズマブ硝子体注射の6ヵ月治療成績
    楠原 仙太郎, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    日本糖尿病眼学会, Apr. 2017, 日本糖尿病眼学会誌, 21, 138 - 138, Japanese
    [Refereed]

  • Icare HOMEを用いた眼圧のホームモニタリングおよび日内変動の検討
    坂本麻里, 金森章泰, 盛崇太郎, 上田香織, 井上結香子, 栗本拓治, Yamada Yuko, Nakamura Makoto
    日本眼科学会, Apr. 2017, 日本眼科学会雑誌, 121(4号) (4号), 366 - 372, Japanese
    [Refereed]
    Scientific journal

  • 健常眼における視神経乳頭中心窩線と耳側縫線の解剖学的位置関係の検討
    栗本 拓治, 盛 崇太朗, 金森 章泰, 若林 星太, 中西 理恵, 坂本 麻里, 上田 香織, 井上 結香子, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 209 - 209, Japanese

  • 流出路再建術の術式別術後短期成績の比較検討
    盛 崇太朗, 金森 章泰, 坂本 麻里, 上田 香織, 井上 結香子, 栗本 拓治, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 245 - 245, Japanese

  • Vogt-小柳-原田病の12ヵ月治療成績と再発に関わるリスク因子の検討
    勝山 敦子, 楠原 仙太郎, 今井 尚徳, 中村 誠
    (公財)日本眼科学会, Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 320 - 320, Japanese
    [Refereed]

  • ぶどう膜炎に伴う高眼圧・緑内障に対する術野展開用鈎を用いた線維柱帯切除術の効果
    楠原 仙太郎, 勝山 敦子, 今井 尚徳, 中村 誠
    (公財)日本眼科学会, Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 323 - 323, Japanese
    [Refereed]

  • Wataru Matsumiya, Shigeru Honda, Keiko Otsuka, Akiko Miki, Takayuki Nagai, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    Mar. 2017, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 255(3) (3), 541 - 548, English
    [Refereed]
    Scientific journal

  • Yoshiko Matsumoto, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Akiyasu Kanamori, Yuko Yamada, Ichiro Nakashima, Makoto Nakamura
    Feb. 2017, PLOS ONE, 12(2) (2), e0171880, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 藤井 誠士郎, 本田 茂, 大塚 慶子, 三木 明子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    (株)メディカル葵出版, Feb. 2017, あたらしい眼科, 34(2) (2), 280 - 282, Japanese
    [Refereed]
    Scientific journal

  • A case of optic nerve sheath meningioma treated with intensity-modulated radiotherapy in neurofibromatosis type 2
    Yuki Matsuno, Yuko Yamada, Yukako Inoue, Akiyasu Kanamori, Makoto Nakamura
    Neuro-Ophthalmology Society of Japan, 2017, Neuro-Ophthalmology Japan, 34(4) (4), 449 - 454, Japanese
    Scientific journal

  • Designation criteria and nationwide epidemiological survey of leber hereditary optic neuropathy in Japan
    Makoto Nakamura, Kaori Ueda
    Neuro-Ophthalmology Society of Japan, 2017, Neuro-Ophthalmology Japan, 34(3) (3), 293 - 299, Japanese
    Scientific journal

  • 毛塚 剛司, 石川 均, 後関 利明, 敷島 敬悟, 山上 明子, 三村 治, 吉富 健志, 平岡 美紀, 中馬 秀樹, 中村 誠, 田中 惠子

      特発性視神経炎と分類される疾患群には，血清中に神経グリア細胞に対する特異抗体である抗アクアポリン4（AQP4）抗体や抗ミエリンオリゴデンドロサイトグリコプロテイン（MOG）抗体がみられることがある．AQP4はアストロサイト上に存在する膜タンパク質であり，その抗体は視神経や脊髄などを標的にして炎症を引き起こす．MOGは中枢神経髄鞘上に存在する分子であり，やはり視神経や脳脊髄に炎症を引き起こす．現在，日本神経眼科学会主導で，自己抗体陽性視神経炎の全国調査が行われており，特発性視神経炎が350例以上エントリーしている．その結果によると，抗AQP4抗体陽性視神経炎は特発性視神経炎の14％前後であり，中年後半の女性に多い．ステロイド治療による視力回復に乏しく，65％以上が矯正視力0.3未満である．多彩な視野障害のパターンをとり，視神経乳頭腫脹，眼球運動時痛が20％前後でみられる．抗AQP4抗体陽性視神経炎は再発することがある．一方，抗MOG抗体陽性視神経炎は，壮年男性にやや多く，ステロイド治療に速やかに反応し，良好な視力回復がえられる．視神経乳頭腫脹や眼球運動時痛が50％以上にみられる．抗MOG抗体陽性視神経炎は，抗AQP4抗体陽性視神経炎より再発しやすい傾向にある．これらの結果から，視神経炎の型を特異抗体で分類することは，予後の推定や長期の治療方針決定に有用と考えられる．

    日本臨床免疫学会, 2017, 日本臨床免疫学会会誌, 40(4) (4), 260b - 260b, Japanese

  • Shunichiro Nakai, Shigeru Honda, Akiko Miki, Wataru Matsumiya, Makoto Nakamura
    2017, OPHTHALMOLOGICA, 237(3) (3), 123 - 127, English
    [Refereed]
    Scientific journal

  • Yuri Ubukata, Hisanori Imai, Keiko Otsuka, Masaya Nishizaki, Rumiko Hara, Mamoru Uenishi, Atsushi Azumi, Makoto Nakamura
    2017, JOURNAL OF OPHTHALMOLOGY, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • スリーブとインジェクターの組み合わせの違いによる白内障手術時の術創健常性の比較検討
    大塚 慶子, 今井 尚徳, 中村 誠
    (株)杏林舎内「IOL&RS」編集事務局, Dec. 2016, IOL & RS, 30(4) (4), 552 - 557, Japanese

  • 実用視力連続3回測定における測定値変化と信頼性についての年代別検討
    田畑 奈緒美, 松宮 亘, 大塚 慶子, 今井 尚徳, 下川 智子, 河賀 友紀, 中村 誠
    (公社)日本視能訓練士協会, Dec. 2016, 日本視能訓練士協会誌, 45, 346 - 346, Japanese

  • OCT angiographyを用いた脈絡膜新生血管検出率
    三木 明子, 本田 茂, 大塚 慶子, 金井 美智子, 近藤 陽子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2016, 眼科臨床紀要, 9(11) (11), 916 - 916, Japanese
    [Refereed]

  • 網膜静脈分枝閉塞症に伴う黄斑浮腫に対するラニビズマブ硝子体注射の6ヵ月治療成績
    楠原 仙太郎, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    眼科臨床紀要会, Nov. 2016, 眼科臨床紀要, 9(11) (11), 920 - 920, Japanese
    [Refereed]

  • 近視性脈絡膜血管新生に対するビスフォスフォネート内服療法の3年経過
    本田 茂, 三木 明子, 大塚 慶子, 金井 美智子, 近藤 陽子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2016, 眼科臨床紀要, 9(11) (11), 936 - 936, Japanese
    [Refereed]

  • 視神経乳頭コロボーマ合併網膜剥離に対して硝子体手術を施行し形態学的改善を得た1例
    金井 美智子, 本田 茂, 大塚 慶子, 三木 明子, 近藤 陽子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Nov. 2016, 眼科臨床紀要, 9(11) (11), 947 - 947, Japanese
    [Refereed]

  • Kenji Kashiwagi, Satoshi Kogure, Fumihiko Mabuchi, Tatsuya Chiba, Tetsuya Yamamoto, Yasuaki Kuwayama, Makoto Araie, Makoto Aihara, Haruki Abe, Aiko Iwase, Yukitaka Uji, Harumi Katsushima, Yoshiaki Kitazawa, Shoichi Sawaguchi, Hiroshi Shimizu, Shiroaki Shirato, Kazuhisa Sugiyama, Yasuyuki Suzuki, Hidenobu Tanihara, Akihiko Tawara, Goji Tomita, Atsuo Tomidokoro, Akira Negi, Takeo Fukuchi, Chota Matsumoto, Hiromu K. Mishima, Keiji Yoshikawa, Takeshi Yoshitomi, Yoshitsugu Inoue, Yumiko Aoyama, Kazuhide Kawase, Takahiro Ban, Akira Sawada, Kiyofumi Mochizuki, Ryusuke Futa, Kenji Nakamoto, Tetsuya Sugiyama, Shota Kojima, Norihiko Hirotsuji, Kiyoshi Kano, Atsushi Ohura, Eriko Kawai, Atsuko Nakata, Rika Kuwamura, Kensuke Okuno, Kenji Yawata, Shun Matsumoto, Haruki Abe, Takeo Fukuchi, Motohiro Shirakashi, Jun Ueda, Takayuki Tanaka, Akira Negi, Makoto Nakamura, Akiyasu Kanamori, Yuko Yamada, Akihiko Tawara, Toshiaki Kubota, Norihiko Tou, Tairo Kimura, Chiaki Furusawa, Naoki Inoue, Kiho Kawabata, Nobuhiko Tachibana, Akira Matsuda, Takahiko Seto, Satoshi Kimura, Satoki Ueno, Naoto Tokuda, Jun Inoue, Kazuhisa Sugiyama, Shinji Ohkubo, Tomomi Higashide, Yoshiaki Saito, Hisashi Takeda, Atsushi Nagata, Yukitaka Uji, Hideyuki Tsukitome, Kunio Ito, Kengo Ikesugi, Miyo Matsumura, Hiroyuki Nambu, Teruhiko Hamanaka, Takayasu Omata, Yukiko Watanabe, Keiko Sakuma, Yoko Amari, Genichiro Takahashi, Takahiko Noro, Hiroshi Miyata, Manabu Hirasawa, Yuichiro Ohtake, Kenya Yuki, Goji Tomita, Makoto Aihara, Atsuo Tomidokoro, Hiroshi Matsuo, Takuya Atarashi, Chihiro Mayama
    Nov. 2016, Acta Ophthalmologica, 94(7) (7), e561 - e570, English
    [Refereed]
    Scientific journal

  • 難治性視神経炎全国調査 計画および導入について
    毛塚 剛司, 石川 均, 後関 利明, 三村 治, 吉冨 健志, 敷島 敬悟, 平岡 美紀, 中馬 秀樹, 中村 誠, 田中 惠子, 抗MOG抗体陽性視神経炎調査班
    日本神経眼科学会, Oct. 2016, 神経眼科, 33(増補1) (増補1), 82 - 82, Japanese
    [Refereed]

  • 難治性視神経炎全国調査 中間結果報告
    後関 利明, 石川 均, 毛塚 剛司, 三村 治, 吉冨 健志, 敷島 敬悟, 平岡 美紀, 中馬 秀樹, 中村 誠, 田中 惠子, 抗MOG抗体陽性視神経炎調査班
    日本神経眼科学会, Oct. 2016, 神経眼科, 33(増補1) (増補1), 84 - 84, Japanese
    [Refereed]

  • 抗AQP4抗体陽性視神経炎に対する血液浄化療法の治療効果
    盛 崇太朗, 栗本 拓治, 坂本 麻里, 上田 香織, 井上 結香子, 千原 典夫, 金森 章泰, 山田 裕子, 中村 誠
    日本神経眼科学会, Oct. 2016, 神経眼科, 33(増補1) (増補1), 86 - 86, Japanese
    [Refereed]

  • 実臨床における糖尿病黄斑浮腫に対するラニビズマブ硝子体注射の12ヵ月治療成績
    楠原 仙太郎, 勝山 敦子, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    (一社)日本糖尿病合併症学会, Sep. 2016, 糖尿病合併症, 30(Suppl.1) (Suppl.1), 254 - 254, Japanese
    [Refereed]

  • Ability of OCT angiography to detect choroidal neovascularization in retinal pigment epithelial detachment associated with chronic central serous chorioretinopathy.
    Akiko Miki, Shigeru Honda, Keiko Otsuka, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    Sep. 2016, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12) (12), English
    [Refereed]
    Scientific journal

  • Schlemm管内皮網除去と深層強膜弁切除を併施した線維柱帯切開術の術後成績
    安田絵里子, 金森章泰, 上田香織, 明石梓, 坂本麻里, 井上結香子, Yamada Yuko, Nakamura Makoto
    日本眼科学会, Sep. 2016, 日本眼科学会雑誌, 120(9号) (9号), 635 - 639, Japanese
    [Refereed]
    Scientific journal

  • Sho Nobuyoshi, Akiyasu Kanamori, Yoshiko Matsumoto, Makoto Nakamura
    Sep. 2016, JAPANESE JOURNAL OF OPHTHALMOLOGY, 60(5) (5), 419 - 423, English
    [Refereed]
    Scientific journal

  • Current Status of Glaucoma-related Data Management and Efforts toward Data Standardization.
    Kashiwag K, Aihara M, Inatani M, Iwase A, Kawase K, Sugiyama K, Nakazawa T, Nakamura M, Fukuchi T, Yoshitomi T, Araie M
    Purpose: Ｗe conducted a survey to evaluate the current status of glaucoma-related medical data management and standardization, aiming to improve the development of glaucoma care and research in Japan. Materials and methods: The survey was performed as a paper-based questionnaire of 14 universities that both participate in the glaucoma-related data standardization committee, established by the Japan Glaucoma Society in 2014, and actively perform glaucoma care. Results: All enrolled university hospitals installed an electronic hospital information system and used any of three ophthalmology-limited electronic chart systems. However, only 30.8% of the hospitals established a data extraction system from an electronic medical chart system, and only 14.3% could practically apply medical data for secondary research purposes. In all, 35.7% of the hospitals operate a medical cooperation system with local medical institutions and 42.9% electronically managed medical data inside their departments. Conclusion: This survey clarified the current state of medical data management and standardization.
    Aug. 2016, Nippon Ganka Gakkai zasshi, 120(8) (8), 540 - 547, Japanese, Domestic magazine
    [Refereed]
    Scientific journal

  • Bilateral corneal ulcer after use colored cosmetic contact lens
    Eriko Yasuda, Takayuki Nagai, Yusa Yamasaki, Wataru Matsumiya, Makoto Nakamura
    Igaku-Shoin Ltd, May 2016, Japanese Journal of Clinical Ophthalmology, 70(5) (5), 741 - 745, Japanese
    Scientific journal

  • Mami Nishisako, Akira Meguro, Eiichi Nomura, Takahiro Yamane, Masaki Takeuchi, Masao Ota, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shinki Chin, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Taylor and Francis Ltd, Apr. 2016, Ophthalmic Genetics, 37(2) (2), 194 - 200, English
    [Refereed]
    Scientific journal

  • 乳頭周囲網膜神経線維層厚の菲薄化の有無による極早期緑内障の層別化
    明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 164 - 164, Japanese

  • 視神経炎における抗AQP4抗体の構造と機能に与える影響
    松本 佳子, 明石 梓, 上田 香織, 坂本 麻里, 井上 結香子, 金森 章泰, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 194 - 194, Japanese

  • IcareHOMEを用いた患者による自己眼圧測定の再現性と日内変動の検討
    坂本 麻里, 金森 章泰, 上田 香織, 明石 梓, 井上 結香子, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 304 - 304, Japanese

  • Lamellar hole associated epiretinal proliferationの有無と全層黄斑円孔の術後成績
    今井 尚徳, 大塚 慶子, 石濱 佳奈, 西崎 雅也, 中村 賢和, 安田 絵里子, 上西 衛, 盛 崇太朗, 原 ルミ子, 勝山 敦子, 安積 淳, 中村 誠
    (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 280 - 280, Japanese

  • 加齢性網膜変化におけるmultidrug resistance protein 4(Mrp4)の役割
    楠原 仙太郎, 延吉 章, 小島 恵子, 松宮 亘, 中村 誠
    (公財)日本眼科学会, Mar. 2016, 日本眼科学会雑誌, 120(臨増) (臨増), 308 - 308, Japanese
    [Refereed]

  • 光干渉断層計を用いた糖尿病網膜内層の2次元的評価
    楠原 仙太郎, 大塚 慶子, 三木 明子, 松宮 亘, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    日本糖尿病眼学会, Mar. 2016, 日本糖尿病眼学会誌, 20, 103 - 103, Japanese
    [Refereed]

  • 鈴木,利根, 中村,誠, 中馬,秀樹, 毛塚,剛司, 中馬越,清隆, 三村,治, 敷島,敬悟, 石川,弘, 大井,長和, 山上,明子, 石川,均, 大黒,浩, 菅澤,淳
    The Japanese Neuro-Ophthalmology Society, 2016, Neuro-Ophthalmology Japan, 33(2) (2), 171 - 184, Japanese
    Scientific journal

  • 視機能異常に対応した病院内設備とカラーユニバーサルデザイン
    Sugano Aki, 松浦正子, 三木明子, Ohta Mika, 中村誠, Takaoka Yutaka
    2016, 信学技報, 116(360) (360), 1 - 4, Japanese
    Scientific journal

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Mari Tomioka, Yuki Kawaka, Makoto Nakamura
    Lippincott Williams and Wilkins, 2016, Journal of Glaucoma, 25(4) (4), 383 - 389, English
    [Refereed]
    Scientific journal

  • Mizuki Tagami, Shigeru Honda, Ichiro Morioka, Kazumoto Iijima, Hideto Yamada, Makoto Nakamura
    BioMed Central Ltd., 2016, BMC Ophthalmology, 16(1) (1), 81, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 糖尿病黄斑浮腫に対するラニビズマブ硝子体注射の6ヵ月治療成績
    楠原 仙太郎, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 本田 茂, 中村 誠
    (一社)日本糖尿病合併症学会, Nov. 2015, 糖尿病合併症, 29(Suppl.1) (Suppl.1), 208 - 208, Japanese
    [Refereed]

  • 糖尿病黄斑浮腫に対するRanibizumab 1回投与後の経過に関する検討
    藤井誠士郎, Honda Shigeru, 三木明子, 今井尚徳, 楠原仙太郎, 中村誠
    (一社)日本糖尿病合併症学会, Nov. 2015, 糖尿病合併症, 29(Suppl.1) (Suppl.1), 221 - 221, Japanese
    [Refereed]
    Scientific journal

  • レーベル遺伝性視神経症の新規発症者数に関する疫学調査
    上田 香織, 森實 祐基, 白神 史雄, 敷島 敬悟, 石川 均, 若倉 雅登, 中村 誠
    日本神経眼科学会, Oct. 2015, 神経眼科, 32(増補1) (増補1), 63 - 63, Japanese

  • ポリープ状脈絡膜血管症に対するアフリベルセプト併用光線力学的療法の6ヵ月成績
    松宮 亘, 本田 茂, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 楠原 仙太郎, 中村 誠
    眼科臨床紀要会, Oct. 2015, 眼科臨床紀要, 8(10) (10), 762 - 763, Japanese
    [Refereed]

  • Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura
    Oct. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(11) (11), 6573 - 6580, English
    [Refereed]
    Scientific journal

  • Yukako Inoue, Kei Kato, Seiko Kamata, Kumiko Ishikawa, Makoto Nakamura
    Oct. 2015, DOCUMENTA OPHTHALMOLOGICA, 131(2) (2), 115 - 124, English
    [Refereed]
    Scientific journal

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura
    Oct. 2015, BRITISH JOURNAL OF OPHTHALMOLOGY, 99(10) (10), 1419 - 1423, English
    [Refereed]
    Scientific journal

  • トラベクレクトミー術後低眼圧黄斑症の発症危険因子の検討
    坂本 麻里, 井上 結香子, 松本 佳子, 明石 梓, 上田 香織, 金森 章泰, 山田 裕子, 中村 誠
    日本緑内障学会, Sep. 2015, 日本緑内障学会抄録集, 26回, 100 - 100, Japanese

  • 3種のSD-OCTのPre-perimetric glaucomaにおける検出力の比較について
    明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠
    日本緑内障学会, Sep. 2015, 日本緑内障学会抄録集, 26回, 143 - 143, Japanese

  • 強度近視として経過観察されていた完全型先天停在性夜盲の1例
    福永とも子, 松宮亘, Nakamura Makoto
    メディカル葵出版, Sep. 2015, あたらしい眼科, 32(9号) (9号), 1355 - 1358, Japanese
    [Refereed]
    Scientific journal

  • Impaired axonal transport in a rodent model of optic neuritis due to NMO spectrum disorder
    Yoshiko Matsumoto, Akiyasu Kanamori, Sho Nobuyoshi, Ichiro Nakashima, Makoto Nakamura
    Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English
    [Refereed]

  • Kaori Ueda, Wataru Matsumiya, Keiko Otsuka, Yoshifumi Maeda, Takayuki Nagai, Makoto Nakamura
    Jun. 2015, BMC OPHTHALMOLOGY, 15, 58, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • [Designation criteria for Leber's hereditary optic neuropathy].
    Nakamura M, Mimura O, Wakakura M, Inatani M, Nakazawa T, Shiraga F
    日本眼科学会, May 2015, Nippon Ganka Gakkai zasshi, 119(5) (5), 339 - 346, Japanese
    [Refereed]

  • Azusa Akashi, Akiko Miki, Akiyasu Kanamori, Makoto Nakamura
    Aquaporin 9 (AQP9), an aquaglyceroporin, is not only permeable to water but also to non-charged solutes, such as lactate. Lactate can be an energy source for retinal neurons. This study aimed to evaluate the effect of the downregulation of AQP9 expression on the survival rates and reactive oxygen species accumulation in RGC-5 cells cultured in a medium containing lactate. The Live/Dead assay revealed that the cell death rate of RGC-5 cells transfected with the control siRNA (siControl) was 3.65%±0.75% in the 5-mM glucose medium. The death rate was significantly increased by five-fold in the no glucose and 10-mM d-lactate media but not in the 10-mM l-lactate medium. In comparison, the death rate of cells transfected with siRNA targeting AQP9 (siAQP9) was 8.07%±1.01% in the 5-mM glucose medium, which was significantly increased by two-fold in the other medium conditions, indicating that the downregulation of AQP9 expression eliminated the prosurvival effect of l-lactate. Few RGC-5 cells transfected with siControl showed dichlorofluorescein (DCF) fluorescence when cultured in 5-mM glucose and 10-mM l-lactate media. However, approximately 70% of those showed DCF fluorescence when cultured in the no glucose and 10-mM d-lactate media. The downregulation of AQP9 significantly increased the DCF fluorescence rate to 50.44%±6.13% in the 10-mM l-lactate medium, whereas, it did not increase the rate in the other medium conditions. These results demonstrate that AQP9 expression is required for l-lactate to maintain retinal neuronal survival.
    Mar. 2015, Neuroscience letters, 589, 185 - 90, English, International magazine
    [Refereed]
    Scientific journal

  • 非高度近視正常眼と高度近視正常眼の高度近視早期緑内障に対するOCT検出力の相違
    明石 梓, 金森 章泰, 上田 香織, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 310 - 310, Japanese

  • シュレム管内皮網除去+深層強膜弁切除を併施したトラベクロトミーの術後成績
    安田 絵里子, 金森 章泰, 上田 香織, 明石 梓, 坂本 麻里, 井上 結香子, 山田 裕子, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 316 - 316, Japanese

  • 病的網膜血管新生におけるMrp4の役割
    楠原 仙太郎, 松宮 亘, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 178 - 178, Japanese
    [Refereed]

  • 続発性中心性漿液性脈絡網膜症における脈絡膜厚の検討
    本田 茂, 三木 明子, 松宮 亘, 大塚 慶子, 今井 尚徳, 長井 隆行, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 196 - 196, Japanese
    [Refereed]

  • ポリープ状脈絡膜血管症に対するアフリベルセプト併用光線力学療法の12ヵ月成績
    松宮 亘, 本田 茂, 大塚 慶子, 三木 明子, 長井 隆行, 今井 尚徳, 楠原 仙太郎, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 245 - 245, Japanese
    [Refereed]

  • 山本 修一, 大出 尚郎, 毛塚 剛司, 若倉 雅登, 野倉 一也, 石川 均, 敷島 敬悟, 山口 修平, 三村 治, 吉冨 健志, 中村 誠
    The Japanese Neuro-Ophthalmology Society, 2015, 神経眼科, 32(2) (2), 184 - 192, Japanese

  • Wataru Matsumiya, Shigeru Honda, Keiko Otsuka, Akiko Miki, Takayuki Nagai, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    2015, OPHTHALMOLOGICA, 234(1) (1), 33 - 39, English
    [Refereed]
    Scientific journal

  • Kaori Ueda, Akiyasu Kanamori, Azusa Akashi, Yuki Kawaka, Yuko Yamada, Makoto Nakamura
    Jan. 2015, JAPANESE JOURNAL OF OPHTHALMOLOGY, 59(1) (1), 55 - 64, English
    [Refereed]
    Scientific journal

  • 三村 治, 不二門 尚, 植木 智志, 毛塚 剛司, 敷島 敬悟, 菅澤 淳, 中馬 秀樹, 中尾 雄三, 中村 誠, 山上 明子, 抗アクアポリン4抗体陽性視神経炎診療ガイドライン作成委員会
    日本神経眼科学会, Dec. 2014, 神経眼科, 31(4) (4), 509 - 525, Japanese

  • Akiko Miki, Akiyasu Kanamori, Makoto Nakamura, Yoshiko Matsumoto, Junji Mizokami, Akira Negi
    Dec. 2014, EXPERIMENTAL EYE RESEARCH, 129, 38 - 47, English
    [Refereed]
    Scientific journal

  • Miki Hirose, Wataru Matsumiya, Shigeru Honda, Makoto Nakamura
    Dove Medical Press Ltd, Nov. 2014, Clinical Ophthalmology, 8, 2301 - 2305, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Azusa Akashi, Akiyasu Kanamori, Kaori Ueda, Yoshiko Matsumoto, Yuko Yamada, Makoto Nakamura
    Jul. 2014, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 55(7) (7), 4667 - 4672, English
    [Refereed]
    Scientific journal

  • Makoto Nakamura, Kei Kato, Seiko Kamata, Kumiko Ishikawa, Takayuki Nagai
    Jun. 2014, DOCUMENTA OPHTHALMOLOGICA, 128(3) (3), 179 - 189, English
    [Refereed]
    Scientific journal

  • 三村 治, 不二門 尚, 植木 智志, 毛塚 剛司, 敷島 敬悟, 菅澤 淳, 中馬 秀樹, 中尾 雄三, 中村 誠, 山上 明子, 抗アクアポリン4抗体陽性視神経炎診療ガイドライン作成委員会
    (公財)日本眼科学会, May 2014, 日本眼科学会雑誌, 118(5) (5), 446 - 460, Japanese

  • Mari Sakamoto, Akiyasu Kanamori, Masashi Fujihara, Yuko Yamada, Makoto Nakamura, Akira Negi
    May 2014, ACTA OPHTHALMOLOGICA, 92(3) (3), 243 - 248, English
    [Refereed]
    Scientific journal

  • Hiroki Kawano, Takashi Ito, Shingo Yamada, Teruto Hashiguchi, Ikuro Maruyama, Toshio Hisatomi, Makoto Nakamura, Taiji Sakamoto
    May 2014, LABORATORY INVESTIGATION, 94(5) (5), 569 - 585, English
    [Refereed]
    Scientific journal

  • Yoshiko Matsumoto, Akiyasu Kanamori, Makoto Nakamura, Akira Negi
    May 2014, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58(3) (3), 290 - 297, English
    [Refereed]
    Scientific journal

  • Yoshiko Matsumoto, Masashi Fujihara, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
    May 2014, JAPANESE JOURNAL OF OPHTHALMOLOGY, 58(3) (3), 267 - 275, English
    [Refereed]
    Scientific journal

  • Yoshiko Matsumoto, Akiyasu Kanamori, Makoto Nakamura, Toshiyuki Takahashi, Ichiro Nakashima, Akira Negi
    Feb. 2014, EXPERIMENTAL EYE RESEARCH, 119, 61 - 69, English
    [Refereed]
    Scientific journal

  • 手術手技のコツ 難治性緑内障に対する羊膜を使った手術のコツ
    Nakamura Makoto
    Oct. 2013, 眼科手術, 26(4号) (4号), 585 - 587, Japanese
    [Refereed][Invited]
    Scientific journal

  • Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi
    Jul. 2013, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(7) (7), 4478 - 4484, English
    [Refereed]
    Scientific journal

  • 【神経眼科Minimum Requirements】 神経眼科領域のOCT
    Nakamura Makoto
    Jun. 2013, あたらしい眼科, 30(6号) (6号), 761 - 768, Japanese
    [Refereed][Invited]
    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi
    May 2013, ACTA OPHTHALMOLOGICA, 91(3) (3), E196 - E202, English
    [Refereed]
    Scientific journal

  • Akiko Miki, Akiyasu Kanamori, Akira Negi, Maiko Naka, Makoto Nakamura
    May 2013, AMERICAN JOURNAL OF PATHOLOGY, 182(5) (5), 1727 - 1739, English
    [Refereed]
    Scientific journal

  • 3種のSD-OCTの乳頭周囲網膜神経線維層厚と視野の相関
    明石 梓, 金森 章泰, 坂本 麻里, 藤原 雅史, 山田 裕子, 中村 誠, 根木 昭
    (公財)日本眼科学会, Mar. 2013, 日本眼科学会雑誌, 117(臨増) (臨増), 334 - 334, Japanese

  • 視神経疾患の新しい展開
    根木 昭, 中村 誠, 金森 章泰, 楠原 あづさ, 中西 頼子, 辰巳 康子, 藤岡 美幸, 田口 真衣子, 福田 昌秀, 田渕 久美子, 三木 明子, 溝上 淳二, 長井 隆行, 藤原 雅史, 山田 裕子
    (公財)日本眼科学会, Mar. 2013, 日本眼科学会雑誌, 117(3) (3), 187 - 211, Japanese
    [Refereed]

  • Hiroki Otsuka, Hiroki Kawano, Shozo Sonoda, Makoto Nakamura, Taiji Sakamoto
    Mar. 2013, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(3) (3), 1758 - 1766, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi
    Feb. 2013, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 251(2) (2), 591 - 595, English
    [Refereed]
    Scientific journal

  • 3種のSD-OCTによる視神経乳頭周囲網膜神経層厚における各象限の比較
    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    Jan. 2013, 日本視能訓練士協会誌, 41, 286, Japanese
    Research society

  • T. Kato, A. Meguro, E. Nomura, R. Uemoto, N. Nomura, M. Ota, K. Kashiwagi, F. Mabuchi, H. Iijima, K. Kawase, T. Yamamoto, M. Nakamura, A. Negi, T. Sagara, T. Nishida, M. Inatani, H. Tanihara, M. Aihara, M. Araie, T. Fukuchi, H. Abe, T. Higashide, K. Sugiyama, T. Kanamoto, Y. Kiuchi, A. Iwase, S. Chin, S. Ohno, H. Inoko, N. Mizuki
    Nature Publishing Group, 2013, Eye (Basingstoke), 27(8) (8), 979 - 983, English
    [Refereed]
    Scientific journal

  • Azusa Akashi, Akiyasu Kanamori, Makoto Nakamura, Masashi Fujihara, Yuko Yamada, Akira Negi
    2013, Investigative Ophthalmology and Visual Science, 54(9) (9), 6025 - 6032, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Maiko Naka, Azusa Akashi, Masashi Fujihara, Yuko Yamada, Makoto Nakamura
    2013, Investigative Ophthalmology and Visual Science, 54(9) (9), 6401 - 6408, English
    [Refereed]
    Scientific journal

  • S. Nakano, A. Kanamori, M. Nakamura, K. Mizukawa, A. Negi
    Nature Publishing Group, 2013, Eye (Basingstoke), 27(10) (10), 1220 - 1221, English
    [Refereed]
    Scientific journal

  • 小脳髄膜腫により腫瘍随伴性視神経症を発症した一例
    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira
    Oct. 2012, 神経眼科, 29(増補1) (増補1), 59, Japanese
    Research society

  • Makoto Nakamura, Kumiko Ishikawa-Tabuchi, Akiyasu Kanamori, Yuko Yamada, Akira Negi
    Oct. 2012, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 250(10) (10), 1499 - 1507, English
    [Refereed]
    Scientific journal

  • 自己眼圧測定器icareONEの精度および安全性の検討
    Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    Sep. 2012, 日本緑内障学会抄録集23回, 153, Japanese
    Research society

  • 視神経切断モデルにおけるsyntaphilinの変化
    Kanamori Akiyasu, Nakamura Makoto, Negi Akira
    Sep. 2012, 日本緑内障学会抄録集23回, 152, Japanese
    Research society

  • ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討
    Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    Sep. 2012, 日本緑内障学会抄録集23回, 116, Japanese
    Research society

  • 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較
    Kanamori Akiyasu, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    Sep. 2012, 日本緑内障学会抄録集23回, 155, Japanese
    Research society

  • Longitudinal Study of Retinal Nerve Fiber Layer Thickness and Ganglion Cell Complex in Traumatic Optic Neuropathy
    Akiyasu Kanamori, Makoto Nakamura, Yuko Yamada, Akira Negi
    Aug. 2012, ARCHIVES OF OPHTHALMOLOGY, 130(8) (8), 1067 - 1069, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Kumiko Tabuchi, Yuko Yamada, Akira Negi
    Jul. 2012, JAPANESE JOURNAL OF OPHTHALMOLOGY, 56(4) (4), 354 - 361, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Makoto Nakamura, Mari Tomioka, Yuki Kawaka, Yuko Yamada, Akira Negi
    Jun. 2012, BRITISH JOURNAL OF OPHTHALMOLOGY, 96(6) (6), 832 - 837, English
    [Refereed]
    Scientific journal

  • 緑内障における多局所視覚誘発電位と構造変化の一致性と相関
    Nakamura Makoto, Negi Akira
    Mar. 2012, 日本眼科学会雑誌, 116(臨増) (臨増), 318, Japanese
    Research society

  • 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化
    Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    Mar. 2012, 日本眼科学会雑誌, 116(臨増) (臨増), 361, Japanese
    Research society

  • Makoto Nakamura, Maiko Naka, Yasuko Tatsumi, Azusa Nagai-Kusuhara, Akiyasu Kanamori, Yuko Yamada, Akira Negi
    Mar. 2012, CURRENT EYE RESEARCH, 37(3) (3), 239 - 250, English
    [Refereed]
    Scientific journal

  • Junji Mizokami, Akiyasu Kanamori, Akira Negi, Makoto Nakamura
    Nov. 2011, CURRENT EYE RESEARCH, 36(11) (11), 1064 - 1067, English
    Scientific journal

  • Makoto Nakamura, Kumiko Ishikawa, Takayuki Nagai, Akira Negi
    Oct. 2011, DOCUMENTA OPHTHALMOLOGICA, 123(2) (2), 93 - 108, English
    [Refereed]
    Scientific journal

  • Patrice E. Fort, Mandy K. Losiewicz, Chad E. N. Reiter, Ravi S. J. Singh, Makoto Nakamura, Steven F. Abcouwer, Alistair J. Barber, Thomas W. Gardner
    Oct. 2011, PLOS ONE, 6(10) (10), English
    [Refereed]
    Scientific journal

  • Junji Mizokami, Yuko Yamada, Akira Negi, Makoto Nakamura
    Jun. 2011, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 249(6) (6), 879 - 885, English
    [Refereed]
    Scientific journal

  • Investigation of the association between SLC1A3 gene polymorphisms and normal tension glaucoma
    Reiko Yasumura, Akira Meguro, Masao Ota, Eiichi Nomura, Riyo Uemoto, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Mar. 2011, MOLECULAR VISION, 17(89-90) (89-90), 792 - 796, English
    Scientific journal

  • Masahide Fukuda, Maiko Naka, Junji Mizokami, Akira Negi, Makoto Nakamura
    Mar. 2011, EXPERIMENTAL EYE RESEARCH, 92(3) (3), 195 - 201, English
    Scientific journal

  • Kumiko Ishikawa, Takayuki Nagai, Yuko Yamada, Akira Negi, Makoto Nakamura
    Feb. 2011, DOCUMENTA OPHTHALMOLOGICA, 122(1) (1), 29 - 37, English
    [Refereed]
    Scientific journal

  • Hiroki Otsuka, Noboru Arimura, Shozo Sonoda, Makoto Nakamura, Teruto Hashiguchi, Ikuro Maruyama, Shintaro Nakao, Ali Hafezi-Moghadam, Taiji Sakamoto
    Nov. 2010, AMERICAN JOURNAL OF PATHOLOGY, 177(5) (5), 2268 - 2277, English
    Scientific journal

  • Maiko Naka, Akiyasu Kanamori, Akira Negi, Makoto Nakamura
    Sep. 2010, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(9) (9), 4618 - 4626, English
    [Refereed]
    Scientific journal

  • Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma
    Misa Suzuki, Akira Meguro, Masao Ota, Eiichi Nomura, Tetsuo Kato, Naoko Nomura, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Sep. 2010, MOLECULAR VISION, 16(203) (203), 1874 - 1879, English
    [Refereed]
    Scientific journal

  • Akira Meguro, Hidetoshi Inoko, Masao Ota, Nobuhisa Mizuki, Seiamak Bahram, Tomoko Shiota, Norihiko Itoh, Naoko Nomura, Kaori Murakami, Mayuki Sato, Eiichi Okada, Hiroyuki Iijima, Kenji Kashiwagi, Fumihiko Mabuchi, Tetsuya Yamamoto, Kazuhide Kawase, Akira Negi, Makoto Nakamura, Teruo Nishida, Takeshi Sagara, Hidenobu Tanihara, Masaru Inatani, Makoto Araie, Makoto Aihara, Haruki Abe, Takeo Fukuchi, Kazuhisa Sugiyama, Tomomi Higashide, Yoshiaki Kiuchi, Takashi Kanamoto, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko
    Jul. 2010, OPHTHALMOLOGY, 117(7) (7), 1331 - U84, English
    [Refereed]
    Scientific journal

  • Analysis of microsatellite polymorphisms within the GLC1F locus in Japanese patients with normal tension glaucoma
    Kaori Murakami, Akira Meguro, Masao Ota, Tomoko Shiota, Naoko Nomura, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Mar. 2010, MOLECULAR VISION, 16(51-52) (51-52), 462 - 466, English
    Scientific journal

  • Marked Cup Reversal Presumably Associated With Scleral Biomechanics in a Case of Adult Glaucoma
    Yoko Kakutani, Makoto Nakamura, Azusa Nagai-Kusuhara, Akiyasu Kanamori, Akira Negi
    Jan. 2010, ARCHIVES OF OPHTHALMOLOGY, 128(1) (1), 139 - 141, English
    [Refereed]
    Scientific journal

  • Masahide Fukuda, Yoriko Nakanishi, Masanori Fuse, Norihide Yokoi, Yasuhiro Hamada, Masafumi Fukagawa, Akira Negi, Makoto Nakamura
    Jan. 2010, EXPERIMENTAL EYE RESEARCH, 90(1) (1), 17 - 25, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • 早発型発達緑内障の弱視化要因
    Nakamura Makoto, Negi Akira
    日本眼科学会, Dec. 2009, 日本眼科学会雑誌, 113巻, 12号, pp. 1145-1152(12) (12), 1145 - 1152, Japanese
    [Refereed]
    Scientific journal

  • Association of toll-like receptor 2 gene polymorphisms with normal tension glaucoma
    Jutaro Nakamura, Akira Meguro, Masao Ota, Eiichi Nomura, Tadayuki Nishide, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Dec. 2009, MOLECULAR VISION, 15(306-07) (306-07), 2905 - 2910, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Maiko Naka, Masahide Fukuda, Makoto Nakamura, Akira Negi
    Oct. 2009, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 247(10) (10), 1353 - 1360, English
    [Refereed]
    Scientific journal

  • 興味ある経過をたどった両眼性特発性視神経炎の小児例
    Nakamura Makoto
    Sep. 2009, 神経眼科, 26巻, 3号, pp. 307-313, Japanese
    [Refereed]
    Scientific journal

  • Maiko Naka, Akiyasu Kanamori, Yasuko Tatsumi, Miyuki Fujioka, Azusa Nagai-Kusuhara, Makoto Nakamura, Akira Negi
    Jun. 2009, JOURNAL OF GLAUCOMA, 18(5) (5), 379 - 384, English
    [Refereed]
    Scientific journal

  • Akiyasu Kanamori, Maiko Naka, Masahide Fukuda, Makoto Nakamura, Akira Negi
    Mar. 2009, EXPERIMENTAL EYE RESEARCH, 88(3) (3), 535 - 541, English
    [Refereed]
    Scientific journal

  • Noboru Arimura, Yuya Ki-i, Teruto Hashiguchi, Ko-ichi Kawahara, Kamal K. Biswas, Makoto Nakamura, Yasushi Sonoda, Keita Yamakiri, Akiko Okubo, Taiji Sakamoto, Ikuro Maruyama
    Mar. 2009, LABORATORY INVESTIGATION, 89(3) (3), 278 - 289, English
    [Refereed]
    Scientific journal

  • A case of bilateral, idiopathic optic neuritis with a unique course in childhood
    Kumiko Ishikawa, Yasuko Tatsumi, Akiyasu Kanamori, Yuko Yamada, Makoto Nakamura
    2009, Neuro-Ophthalmology Japan, 26(3) (3), 307 - 313, Japanese
    Scientific journal

  • Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis
    Nakamura Makoto
    2009, Clinical ophthalmology (Auckland, N.Z.), Vol. 3, No. , pp. 183-8, English
    [Refereed]
    Scientific journal

  • Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population.
    Kayo Nakamura, Masao Ota, Akira Meguro, Naoko Nomura, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    BACKGROUND: To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG) in Japanese patients. MATERIALS AND METHODS: We used polymerase chain reaction amplification with sequence-specific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gender-matched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement. RESULTS: One allele of D7S2462 exhibited a frequency that was significantly decreased in NTG cases compared to controls (P = 0.0013, Pc = 0.019, OR = 0.48, 95% CI = 0.30-0.75). Alleles at another six microsatellite loci were positively or negatively associated with NTG, but these associations did not retain statistical significance after Bonferroni correction (P < 0.05, Pc > 0.05). CONCLUSION: Our study showed a significant association between the GPDS1 locus and NTG, suggesting that there may be some genetic risk factor(s) in the development of NTG.
    2009, Clinical ophthalmology (Auckland, N.Z.), 3, 307 - 12, English, International magazine
    [Refereed]
    Scientific journal

  • Serous Macular Detachment Due to Diabetic Papillopathy Detected Using Optical Coherence Tomography
    Makoto Nakamura, Akiyasu Kanamori, Azusa Nagai-Kusuhara, Sentrao Kusuhara, Yuko Yamada, Akira Negi
    Jan. 2009, ARCHIVES OF OPHTHALMOLOGY, 127(1) (1), 105 - 107, English
    [Refereed]
    Scientific journal

  • Association of Optic Disc Configuration and Clustered Visual Field Sensitivity in Glaucomatous Eyes With Hemifield Visual Field Defects
    Azusa Nagai-Kusuhara, Makoto Nakamura, Akiyasu Kanamori, Akira Negi
    Jan. 2009, JOURNAL OF GLAUCOMA, 18(1) (1), 62 - 68, English
    [Refereed]
    Scientific journal

  • Regional Relationship Between Retinal Nerve Fiber Layer Thickness and Corresponding Visual Field Sensitivity in Glaucomatous Eyes
    Akiyasu Kanamori, Maiko Naka, Azusa Nagai-Kusuhara, Yuko Yamada, Makoto Nakamura, Akira Negi
    Nov. 2008, ARCHIVES OF OPHTHALMOLOGY, 126(11) (11), 1500 - 1506, English
    [Refereed]
    Scientific journal

  • Yusuke Murakami, Yasuhiro Ikeda, Yoshikazu Yonemitsu, Mitsuho Onimaru, Kazunori Nakagawa, Ri-ichiro Kohno, Masanori Miyazaki, Toshio Hisatomi, Makoto Nakamura, Takeshi Yabe, Mamoru Hasegawa, Tatsuro Ishibashi, Katsuo Sueishi
    Nov. 2008, AMERICAN JOURNAL OF PATHOLOGY, 173(5) (5), 1326 - 1338, English
    [Refereed]
    Scientific journal

  • A. Nagai-Kusuhara, M. Nakamura, Y. Tatsumi, Y. Nakanishi, A. Negi
    Oct. 2008, BRITISH JOURNAL OF OPHTHALMOLOGY, 92(10) (10), 1382 - 1386, English
    [Refereed]
    Scientific journal

  • Etsuko Shibuya, Akira Meguro, Masao Ota, Kenji Kashiwagi, Fumihiko Mabuchi, Hiroyuki Iijima, Kazuhide Kawase, Tetsuya Yamamoto, Makoto Nakamura, Akira Negi, Takeshi Sagara, Teruo Nishida, Masaru Inatani, Hidenobu Tanihara, Makoto Aihara, Makoto Araie, Takeo Fukuchi, Haruki Abe, Tomomi Higashide, Kazuhisa Sugiyama, Takashi Kanamoto, Yoshiaki Kiuchi, Aiko Iwase, Shigeaki Ohno, Hidetoshi Inoko, Nobuhisa Mizuki
    Oct. 2008, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 49(10) (10), 4453 - 4457, English
    [Refereed]
    Scientific journal

  • M. Akiyama, K. Yatsu, M. Ota, Y. Katsuyama, K. Kashiwagi, F. Mabuchi, H. Iijima, K. Kawase, T. Yamamoto, M. Nakamura, A. Negi, T. Sagara, N. Kumagai, T. Nishida, M. Inatani, H. Tanihara, S. Ohno, H. Inoko, N. Mizuki
    Sep. 2008, BRITISH JOURNAL OF OPHTHALMOLOGY, 92(9) (9), 1293 - 1296, English
    [Refereed]
    Scientific journal

  • A. Nagai-Kusuhara, M. Nakamura, A. Kanamori, Y. Nakanishi, S. Kusuhara, Akira Negi
    Sep. 2008, EYE, 22(9) (9), 1154 - 1160, English
    [Refereed]
    Scientific journal

  • Azusa Nagai-Kusuhara, Makoto Nakamura, Miyuki Fujioka, Akira Negi
    Apr. 2008, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 246(4) (4), 567 - 571, English
    Scientific journal

  • A. Nagai-Kusuhara, M. Nakamura, M. Fujioka, Y. Tatsumi, A. Negi
    Feb. 2008, BRITISH JOURNAL OF OPHTHALMOLOGY, 92(2) (2), 186 - 190, English
    Scientific journal

  • Yasuko Tatsumi, Akiyasu Kanamori, Azusa Nagai-Kusuhara, Yoriko Nakanishi, Neeraj Agarwal, Akira Negi, Makoto Nakamura
    2008, CURRENT EYE RESEARCH, 33(8) (8), 683 - 692, English
    [Refereed]
    Scientific journal

  • Yasuko Tatsumi, Makoto Nakamura, Miyuki Fujioka, Yoriko Nakanishi, Azusa Kusuhara, Hidetaka Maeda, Akira Negi
    May 2007, BRITISH JOURNAL OF OPHTHALMOLOGY, 91(5) (5), 633 - 637, English
    [Refereed]
    Scientific journal

  • Miyuki Fujioka, Makoto Nakamura, Yasuko Tatsumi, Azusa Kusuhara, Hidetaka Maeda, Akira Negi
    Feb. 2007, CURRENT EYE RESEARCH, 32(2) (2), 89 - 94, English
    [Refereed]
    Scientific journal

  • Azusa Nagai-Kusuhara, Makoto Nakamura, Hirokazu Mukuno, Akiyasu Kanamori, Akira Negi, Gail M. Seigel
    Jan. 2007, EXPERIMENTAL EYE RESEARCH, 84(1) (1), 152 - 162, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Intraocular pressure lowering effect of once daily versus once weekly latanoprost instillation in the same normal individuals
    Urtogtah Darhad, Makoto Nakamura, Miyuki Fujioka, Yasuko Tatsumi, Azusa Nagai-Kusuhara, Hidetaka Maeda, Akira Negi
    2007, Kobe Journal of Medical Sciences, 53(6) (6), 297 - 304, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoriko Nakanishi, Makoto Nakamura, Yasuko Tatsumi, Azusa Nagai-Kusuhara, Akira Negi
    Nov. 2006, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 244(11) (11), 1480 - 1484, English
    [Refereed]
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Yoriko Nakanishi, Makoto Nakamura, Hirokazu Mukuno, Akiyasu Kanamori, Gail M. Seigel, Akira Negi
    Nov. 2006, EXPERIMENTAL EYE RESEARCH, 83(5) (5), 1108 - 1117, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • S. Kusuhara, M. Nakamura, A. Nagai-Kusuhara, Y. Nakanishi, A. Kanamori, A. Negi
    Aug. 2006, EYE, 20(8) (8), 882 - 887, English
    [Refereed]
    Scientific journal

  • Agreement of rebound tonometer in measuring intraocular pressure with three types of applanation tonometers
    Makoto Nakamura, Urtogtah Darhad, Yasuko Tatsumi, Miyuki Fujioka, Azusa Kusuhara, Hidetaka Maeda, Akira Negi
    Aug. 2006, AMERICAN JOURNAL OF OPHTHALMOLOGY, 142(2) (2), 332 - 334, English
    Scientific journal
    Link to Kobe Univ. Repository (Kernel)

  • Diabetes reduces basal retinal insulin receptor signaling - Reversal with systemic and local insulin
    CEN Reiter, XH Wu, L Sandirasegarane, M Nakamura, KA Gilbert, RSJ Singh, PE Fort, DA Antonetti, TW Gardner
    Apr. 2006, DIABETES, 55(4) (4), 1148 - 1156, English
    [Refereed]
    Scientific journal

  • 緑内障眼におけるGDx-variable corneal compensation,光干渉断層計,ハイデルベルグレチナトモグラフによる解析結果ならびに視野障害に対する相関
    KANAMORI,Akiyasu, 楠原あづさ, 辰巳康子, 藤岡美幸, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    日本眼科学会, Mar. 2006, 日本眼科学会雑誌, 110巻, 3号, pp.180-187(3) (3), 180 - 187, Japanese
    [Refereed]
    Scientific journal

  • A Kanamori, A Nagai-Kusuhara, MFT Escano, H Maeda, M Nakamura, A Negi
    Jan. 2006, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 244(1) (1), 58 - 68, English
    Scientific journal

  • 非緑内障性視神経症による乳頭陥凹
    NAKAMURA, Makoto
    Sep. 2005, 緑内障, 15巻, 1, pp.21-23, Japanese
    [Refereed]
    Scientific journal

  • Y Tatsumi, A Kanamori, A Kusuhara, Y Nakanishi, S Kusuhara, M Nakamura
    Jul. 2005, JAPANESE JOURNAL OF OPHTHALMOLOGY, 49(4) (4), 294 - 296, English
    Scientific journal

  • A Kanamori, M Nakamura, Y Nakanishi, Y Yamada, A Negi
    Jul. 2005, EXPERIMENTAL EYE RESEARCH, 81(1) (1), 48 - 56, English
    Scientific journal

  • 非緑内障性視神経症による乳頭陥凹
    NAKAMURA, Makoto
    メディカル葵出版, May 2005, あたらしい眼科, 22巻, 5, pp.661-663(5) (5), 661 - 663, Japanese
    [Refereed]
    Scientific journal

  • 小児白内障術後の近見・遠見視力発達
    中島由美恵, 宮浦望, 調廣子, KUSUHARA, Sentaro, ISHIBASHI, Kazuki, NAKAMURA, Makoto, 山本節
    眼科臨床医報会, Mar. 2005, 眼科臨床医報, 99(3) (3), 231 - 233, Japanese
    [Refereed]
    Scientific journal

  • M Nakamura, A Kanamori, S Kusuhara, K Ishibashi, A Negi
    Feb. 2005, EYE, 19(2) (2), 235 - 237, English
    [Refereed]
    Scientific journal

  • Unilateral manifestation of Leber's hereditary optic neuropathy after blunt ocular
    A Nagai, M Nakamura, S Kusuhara, A Kanamori, A Negi
    Jan. 2005, JAPANESE JOURNAL OF OPHTHALMOLOGY, 49(1) (1), 65 - 67, English
    [Refereed]
    Scientific journal

  • H Mukuno, M Nakamura, A Kanamori, A Nagai, A Negi, GM Seigel
    Dec. 2004, CURRENT EYE RESEARCH, 29(6) (6), 457 - 464, English
    [Refereed]
    Scientific journal

  • A Kanamori, M Nakamura, N Matsui, A Nagai, Y Nakanishi, S Kusuhara, Y Yamada, A Negi
    Dec. 2004, OPHTHALMOLOGY, 111(12) (12), 2278 - 2283, English
    [Refereed]
    Scientific journal

  • A Kanamori, M Nakamura, Y Nakanishi, A Nagai, H Mukuno, Y Yamada, A Negi
    Oct. 2004, BRAIN RESEARCH, 1022(1-2) (1-2), 195 - 204, English
    [Refereed]
    Scientific journal

  • 相対的求心性瞳孔障害と光干渉断層計で測定した網膜神経線維層厚の関係
    中西頼子, NAKAMURA, Makoto, 永井あづさ, KANAMORI,Akiyasu, KUSUHARA, Sentaro, MAEDA,Hidetaka, SEKIYA,Yoshibumi, NEGI, Akira
    日本神経眼科学会, Oct. 2004, 神経眼科, 21(増補1) (増補1), 89 - 89, Japanese
    International conference proceedings

  • トラベクレクトミー施行後の濾過胞炎と鑑別を要したred eye症候群の一症例
    楯谷直子, 辰巳康子, 藤岡美幸, 永井あづさ, KANAMORI,Akiyasu, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    Sep. 2004, 緑内障, 14巻, 臨増, pp. 172-172, Japanese
    International conference proceedings

  • GDx-VCC,光干渉断層計,HRTの早期緑内障診断における比較検討
    KANAMORI,Akiyasu, 永井あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    Sep. 2004, 緑内障, 14巻, 臨増, pp. 106-106, Japanese
    International conference proceedings

  • 神経線維腫症に合併した先天緑内障の1例
    福村美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    Aug. 2004, 眼科臨床医報, 98巻, 8号, pp. 687-690, Japanese
    [Refereed]
    Scientific journal

  • 緑内障眼における上下半視野の網膜神経線維層厚の光干渉断層計による解析
    KANAMORI,Akiyasu, 瀬谷隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    Apr. 2004, 日本眼科学会雑誌, 108巻, 4, pp. 213-218(4) (4), 213 - 218, Japanese
    Scientific journal

  • A Kanamori, M Nakamura, N Matsui, H Tomimori, M Tanase, R Seya, H Maeda, A Negi
    Feb. 2004, JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 30(2) (2), 513 - 516, English
    [Refereed]
    Scientific journal

  • Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure
    A Kanamori, M Nakamura, H Mukuno, H Maeda, A Negi
    Jan. 2004, CURRENT EYE RESEARCH, 28(1) (1), 47 - 54, English
    [Refereed]
    Scientific journal

  • 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少
    曽和 美幸, 楠原 仙太郎, 永井 あづさ, 中西 頼子, 金森 章泰, 山田 裕子, 中村 誠, 根木 昭, 関谷 善文
    日本神経眼科学会, Dec. 2003, 神経眼科, 20(増補1) (増補1), 43 - 43, Japanese
    [Refereed]

  • 晩発性濾過胞漏出に対する羊膜を用いた濾過胞再建術
    椋野洋和, KANAMORI,Akiyasu, NAKAMURA, Makoto, 瀬谷隆, KATAKAMI,Chikako, MAEDA,Hidetaka, NEGI, Akira
    医学書院, Nov. 2003, 臨床眼科, 57巻, 12号, pp. 1699-1704(12) (12), 1699 - 1704, Japanese
    [Refereed]
    Scientific journal

  • A Kanamori, MFT Escano, A Eno, M Nakamura, H Maeda, R Seya, K Ishibashi, A Negi
    Jul. 2003, OPHTHALMOLOGICA, 217(4) (4), 273 - 278, English
    [Refereed]
    Scientific journal

  • 近視様乳頭眼の網膜神経線維層の解析 正常眼及び初期緑内障眼の比較
    KANAMORI,Akiyasu, 瀬谷隆, 繪野亜矢子, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    Jun. 2003, 眼科臨床医報, 97巻, 6号, pp. 497-497, Japanese
    International conference proceedings

  • A case of occult macular dystrophy accompanying normal-tension glaucoma
    M Nakamura, A Kanamori, H Maeda, A Negi
    May 2003, AMERICAN JOURNAL OF OPHTHALMOLOGY, 135(5) (5), 715 - 717, English
    [Refereed]
    Scientific journal

  • Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography
    A Kanamori, M Nakamura, MFT Escano, R Seya, H Maeda, A Negi
    Apr. 2003, AMERICAN JOURNAL OF OPHTHALMOLOGY, 135(4) (4), 513 - 520, English
    [Refereed]
    Scientific journal

  • H. Maeda, M. Nakamura, A. Negi
    Royal College of Ophthalmologists, 2001, Eye, 15(2) (2), 163 - 167, English
    [Refereed]
    Scientific journal

  • Makoto Nakamura, Masumi Tanabe, Yuko Yamada, Atsushi Azumi
    2000, American Journal of Ophthalmology, 129(6) (6), 809 - 810, English
    [Refereed]
    Scientific journal

  • Makoto Nakamura, Rumiko Hara, Ryohei Kimura, Nobuaki Ohgiya, Naruaki Yamamoto, Ichiro Morino, Misao Yamamoto
    1999, Neuro-Ophthalmology, 21(3) (3), 135 - 145, English
    [Refereed]
    International conference proceedings

  • SHIRABE Hiroko, MORI Yumiko, SUDA Kazuyo, NAKAMURA Makoto, SEKIYA Yoshibumi, YAMAMOTO Misao
    We retrospectively reviewed the management of form deprivation amblyopia in 10 bilateral congenital, 12 unilateral congenital and 3 unilateral traumatic cataract cases who were operated until 4 years of age. The patients with bilateral congenital cataract achieved the best postoperative visual outcome and showed good compliance with rehabilitation. Poor visual prognosis in unilateral congenital cataract correlated with age at surgery and most patients were not compliant. However, there was one case who underwent very early surgery and showed tremendous visual improvement. The traumatic cataract cases complied well with visual rehabilitation and ended up with a good postoperative visual function. The deprivation amblyopia in early onset cataract can be prevented by early surgery and rehabilitation including the psychological support of the parents.
    JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTISTS, Nov. 1998, JOURNAL OF JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTIST, 26, 119 - 127, Japanese

  • Mori Yumiko, Suda Kazuyo, Shirabe Hiroko, Nakamura Makoto, Sekiya Yoshibumi, Yamamoto Misao
    We prescribed low vision aids like Vixen magnifier, glasses with powerful convex lenses, telescope and absorptive lenses for 38 low vision patients whose age varied between 12 and 87 years. We retrospectively reviewed and compared the nature of the disease, visual acuity, age, and the visual field in each prescription group. There was no significant difference between patients prescribed Vixen magnifier or powerful convex lenses in terms of visual acuity. However, most of the patients who received magnifiers were less than 25 years of age and had optic nerve disease. On the other hand, patients who were prescribed powerful convex lenses were older than 25 and most of them had diabetic retinopathy. Patients with telescope lenses were younger than 25 and one half had optic nerve disease whereas those who received absorptive lenses had retinitis pigmentosa as the main cause of low acuity.
    We think that improving the residual visual function in patients with low vision is one of the major tasks of the orthoptist.
    JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTISTS, 1998, JOURNAL OF JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTIST, 26, 269 - 273, Japanese

  • Shirabe Hiroko, Mori Yumiko, Suda Kazuyo, Nakamura Makoto, Sekiya Yoshibumi, Yamamoto Misao
    We studied the postoperative visual acuity and stereopsis in 14 eyes of 8 cases who underwent early surgery for bilateral and unilateral cataracts. Bilateral cataract extractions were performed from 8 to 24 weeks (mean 17.3±5.5 wks), whereas unilateral extractions at 3 and 20 weeks. All patients immediately received hard contact lens fitting and occlusion therapy postoperatively. All bilateral cases achieved a V. A. of 0.6 or better with 7 eyes attaining 1.0 V. A.. One unilateral case had visual improvement of up to 1.0, whereas the other case with poor occlusion compliance had a V. A. of 0.04. Stereopsis was shown in 4 bilateral cases. Unilateral cases could not obtain even gross stereopsis.
    We acknowledged the difficulty of the achivement of binocular visual functions in unilateral cataract cases.
    JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTISTS, 1997, JOURNAL OF JAPANESE ASSOCIATION OF CERTIFIED ORTHOPTIST, 25, 139 - 143, Japanese

■ MISC
  • 抗MOG抗体関連疾患におけるくすぶり病変は疾患活動性を反映する
    刀坂 公崇, 千原 典夫, 栗本 拓治, 十河 正弥, 関谷 博顕, 上田 健博, 関口 兼司, 中村 誠, 松本 理器
    (一社)日本神経学会, Sep. 2021, 臨床神経学, 61(Suppl.) (Suppl.), S259 - S259, Japanese

  • Microhook線維柱帯切開術眼内法とTrabectomeの非劣性を検討する多施設臨床研究
    中村 誠, 溝上 志朗, 東出 朋巳, 庄司 信行, 赤木 忠道, 庄司 拓平, 横山 悠, 植田 俊彦, 齋藤 雄太, 谷戸 正樹, 井上 賢治
    日本緑内障学会, Oct. 2020, 日本緑内障学会抄録集, 31回, 38 - 38, Japanese

  • Sentaro Kusuhara, Makoto Nakamura
    Dove Medical Press Ltd, 2020, Clinical Ophthalmology, 14, 1229 - 1236, English
    Book review

  • Trabectome vs Microhook線維柱帯切開術の眼圧下降効果と安全性の多施設共同ランダム化介入非劣性検証試験
    中村 誠, 溝上 志朗, 東出 朋巳, 庄司 信行, 赤木 忠道, 庄司 拓平, 横山 悠, 植田 俊彦, 齋藤 雄太, 谷戸 正樹
    日本緑内障学会, Sep. 2019, 日本緑内障学会抄録集, 30回, 47 - 47, Japanese

  • ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した1例
    山田 裕子, 栗本 拓治, 盛 崇太朗, 坂本 麻里, 上田 香織, 中井 友昭, 魚住 洋一, 豊田 晶徳, 中西 裕子, 中村 誠
    日本神経眼科学会, Nov. 2018, 神経眼科, 35(増補1) (増補1), 84 - 84, Japanese

  • 【神経眼科とOCT】 視神経炎のOCT
    松本佳子, Nakamura Makoto
    Nov. 2018, 眼科, 60(12) (12), 1441 - 1447, Japanese
    [Invited]
    Introduction scientific journal

  • 【主訴と所見からみた眼科 common disease】所見からみた診断の進め方 視神経 大乳頭・小乳頭
    栗本拓治, Nakamura Makoto
    Sep. 2018, 眼科, 60(10号) (10号), 1195 - 1200, Japanese
    [Invited]
    Introduction scientific journal

  • 序説：続発緑内障
    山本哲也, Nakamura Makoto
    Aug. 2018, あたらしい眼科, 35(8) (8), 1007 - 1008, Japanese
    [Invited]
    Introduction scientific journal

  • 【わかりやすい感覚器疾患】 感覚器の構造と機能 視覚 視覚経路
    Nakamura Makoto
    Jun. 2018, 日本医師会雑誌, 147(特別1) (特別1), S48 - S49, Japanese
    [Invited]
    Introduction scientific journal

  • RAPD あるのか,ないのか,それが神経眼科的問題だ!
    Nakamura Makoto
    Jun. 2018, 臨床眼科, 72(6号) (6号), 755 - 764, Japanese
    [Invited]
    Introduction scientific journal

  • 3歳女児に生じたVogt‐小柳‐原田病疑い症例
    勝山敦子, 楠原仙太郎, 粟野宏之, 永瀬裕朗, 松宮亘, 中村誠
    2018, 日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集, 55th-52nd-61st-7th, 97, Japanese

  • 谷原秀信, 相原一, 稲谷大, 井上俊洋, 木内良明, 杉山和久, 富田剛司, 中澤徹, Nakamura Makoto, 東出朋巳, 福地健郎
    (公財)日本眼科学会, Jan. 2018, 日本眼科学会雑誌, 122(1) (1), 5 - 53, Japanese
    Introduction scientific journal

  • 【視神経炎最前線】 レーベル遺伝性視神経症のイデベノン療法と遺伝子治療
    上田香織, Nakamura Makoto
    医学書院, Nov. 2017, 臨床眼科, 71(12号) (12号), 1666 - 1670, Japanese
    [Invited]
    Introduction scientific journal

  • 【眼科救急Q&A】 救急疾患ごとの基本的な対処法 視神経 レーベル遺伝性視神経症の診断と治療について教えてください
    Nakamura Makoto
    メディカル葵出版, Nov. 2017, あたらしい眼科, 34(臨増) (臨増), 266 - 269, Japanese
    [Invited]
    Introduction scientific journal

  • Nakamura Makoto, 上田香織
    In conjunction with a working group for retina-choroidal and optic atrophy funded by the Ministry of Health, Labor, and Welfare (MHLW), the Japanese Neuro-ophthalmology Society has recently defined the Designation Criteria for Leber hereditary optic neuropathy (LHON) and has conducted a nationwide epidemiological survey on LHON to justify its eligibility as a specified intractable disease defined by MHLW. According to the characteristic major symptoms and ancillary prognostic test results, the criteria classify patients with LHON into definite, probable, and possible cases, as well as asymptomatic carriers. Questionnaires were sent to 1\_h,\/397 facilities, which were certified by either the Japanese Ophthalmological Society or the Japanese Neuro-ophthalmology Society, to determine the number and sex of patients with definite and probable LHON who had one of three mitochondrial DNA mutations at nucleotide positions 3460, 11778, or 14484 and had newly developed symptoms during the year 2014. One hundred seventeen patients were estimated to have newly developed LHON (95% confidence interval, 81 to 153). Over 86% and 90% of these patients possessed the 11778 mutation and were male, respectively, and both percentages were higher than those reported previously in foreign countries. The median age at onset was over 30 years, which was older than previously reported. The establishment of the Designation Criteria and identification of the number of patients not only fulfill the eligibility of LHON as a specified intractable disease but also attract general ophthalmologists' interest towards LHON. Moreover, it motivates researchers and pharmaceutical companies to develop new treatment modalities for LHON.
    The Japanese Neuro-Ophthalmology Society, Sep. 2017, 神経眼科, 34(3号) (3号), 293 - 299, Japanese
    [Invited]
    Introduction scientific journal

  • 難治性視神経炎全国調査 中間結果報告
    後関 利明, 石川 均, 毛塚 剛司, 三村 治, 吉冨 健志, 敷島 敬悟, 平岡 美紀, 中馬 秀樹, 中村 誠, 田中 惠子
    (公財)日本眼科学会, Apr. 2017, 日本眼科学会雑誌, 121(4) (4), 383 - 384, Japanese

  • 早発型発達緑内障における原因遺伝子の探索
    布施 昇男, 木村 雅恵, 清水 愛, 河合 洋介, 小島 要, 長崎 正朗, 濱中 輝彦, 石田 誠夫, 中村 誠, 酒井 寛, 池田 陽子, 森 和彦, 中澤 徹, 勝岡 史城, 安田 純, 山本 雅之
    (公財)日本眼科学会, Mar. 2017, 日本眼科学会雑誌, 121(臨増) (臨増), 227 - 227, Japanese

  • 目でみるシリーズ 画像でみる緑内障の病態(第8回) 前眼部画像検査による濾過胞評価
    Nakamura Makoto
    Feb. 2017, Frontiers in Glaucoma, (53号) (53号), 1 - 8, Japanese
    [Invited]
    Introduction commerce magazine

  • Mrp4 deficiency has no apparent effect on age-related changes of the mouse retina
    Sentaro Kusuhara, Sho Nobuyoshi, Keiko Kojima, Wataru Matsumiya, Makoto Nakamura
    Sep. 2016, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57(12) (12), English
    Summary international conference

  • 緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み
    柏木 賢治, 相原 一, 稲谷 大, 岩瀬 愛子, 川瀬 和秀, 杉山 和久, 中澤 徹, 中村 誠, 福地 健郎, 吉冨 健志, 新家 眞
    (公財)日本眼科学会, Aug. 2016, 日本眼科学会雑誌, 120(8) (8), 540 - 547, Japanese

  • 目でみるシリーズ 画像でみる緑内障の病態(第7回) OCT所見による緑内障と神経眼科疾患の違い
    Nakamura Makoto
    Aug. 2016, Frontiers in Glaucoma, (52号) (52号), 85 - 93, Japanese
    [Invited]
    Introduction commerce magazine

  • 【視神経炎と視神経症:全身と眼の架け橋】 レーベル遺伝性視神経症の最前線
    Nakamura Makoto
    メディカル葵出版, May 2016, あたらしい眼科, 33(5号) (5号), 671 - 677, Japanese
    [Invited]
    Introduction scientific journal

  • カラーコンタクトレンズの色素に対するアレルギー反応が疑われた両眼角膜潰瘍の1例
    安田絵里子, 長井隆行, 山崎悠佐, 松宮亘, Nakamura Makoto
    (株)医学書院, May 2016, 臨床眼科, 70(5) (5), 741 - 745, Japanese
    [Refereed]
    Report scientific journal

  • 日本眼科学会専門医制度生涯教育講座 神経眼科疾患の光干渉断層計像
    Nakamura Makoto
    日本眼科学会, Apr. 2016, 日本眼科学会雑誌, 120(4号) (4号), 339 - 351, Japanese
    [Invited]
    Introduction scientific journal

  • 遺伝性視神経症 (特集 視野異常を診断する)
    山田 裕子, 中村 誠
    金原出版, Dec. 2015, 眼科, 57(13) (13), 1653 - 1660, Japanese

  • 【視覚障害の早期発見と治療】 遭遇することの多い視神経疾患
    Nakamura Makoto
    日本医師会, Dec. 2015, 日本医師会雑誌, 144(9号) (9号), 1827 - 1830, Japanese
    [Invited]
    Introduction scientific journal

  • 緑内障診療データの管理と共通化の現状とデータ共通化に向けての取り組み
    柏木 賢治, 吉冨 健志, 岩瀬 愛子, 杉山 和久, 川瀬 和秀, 中村 誠, 相原 一, 中澤 徹, 福地 健郎, 稲谷 大, 新家 眞
    日本緑内障学会, Sep. 2015, 日本緑内障学会抄録集, 26回, 126 - 126, Japanese

  • 視神経乳頭腫脹を契機として発見された肺線癌の１例
    金井友範, 西崎雅也, Yamada Yuko, 金森斎修, 田邊益美, Kanamori Akiyasu, Nakamura Makoto
    医学書院, Sep. 2015, 臨床眼科, 69(9) (9), 1395 - 1399, Japanese
    [Refereed]
    Report scientific journal

  • The Ability of SD-OCT to Differentiate Early Glaucoma in Highly Myopia from Highly Myopic Control
    Akiyasu Kanamori, Azusa Akashi, Kaori Ueda, Mari Sakamoto, Yukako Inoue, Yuko Yamada, Makoto Nakamura
    Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English
    Summary international conference

  • The OCT findings of macula and associated factors in patients with a history of retinopathy of prematurity
    Akiko Miki, Shigeru Honda, Yoshiko Matsumoto, Azusa Akashi, Yuko Yamada, Makoto Nakamura
    Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English
    Summary international conference

  • The role of Mrp4 in pathological angiogenesis of the mouse retina
    Sentaro Kusuhara, Wataru Matsumiya, Makoto Nakamura
    Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English
    Summary international conference

  • Trabeculotomy with Schlemm's canal endothelium removal and deep sclerectomy
    Eriko Yasuda, Akiyasu Kanamori, Kaori Ueda, Azusa Akashi, Yukako Inoue, Yuko Yamada, Makoto Nakamura
    Jun. 2015, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 56(7) (7), English
    Summary international conference

  • 肥厚性硬膜炎と眼症状
    松本佳子, Nakamura Makoto
    金原出版, Jun. 2015, 眼科, 57(7号) (7号), 937 - 942, Japanese
    [Invited]
    Introduction scientific journal

  • 【極める!副作用モニタリング】 症例でわかる 実臨床で注意すべき副作用とモニタリング 眼科疾患
    Kusuhara Sentaro, Nakamura Makoto
    (株)じほう, Jun. 2015, 調剤と情報, 21(7) (7), 864 - 868, Japanese
    [Invited]
    Introduction commerce magazine

  • Leber遺伝性視神経症認定基準
    Nakamura Makoto, 三村治, 若倉雅登, 稲谷大, 中澤徹, 白神史雄
    日本眼科学会, May 2015, 日本眼科学会雑誌, 119(5号) (5号), 339 - 346, Japanese
    [Refereed]
    Introduction scientific journal

  • 視神経脊髄炎関連疾患における視神経炎の軸索輸送障害
    松本 佳子, 金森 章泰, 延吉 章, 中島 一郎, 中村 誠
    (公財)日本眼科学会, Mar. 2015, 日本眼科学会雑誌, 119(臨増) (臨増), 213 - 213, Japanese

  • 視路疾患と光干渉断層計
    Nakamura Makoto
    Mar. 2015, 日本の眼科, 86(3号) (3号), 275 - 276, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 中心性漿液性脈絡網膜症に対する時間短縮光線力学的療法における照射径設定法の比較
    福永とも子, 三木明子, 松宮亘, 長井隆行, 本田茂, 中村誠
    2015, 日本眼科学会雑誌, 119

  • 遺伝性視神経症に治療法があると聞いたのですが
    Nakamura Makoto
    Dec. 2014, あたらしい眼科, 31(臨時増刊) (臨時増刊), 134 - 135, Japanese
    [Invited]
    Introduction scientific journal

  • 電気生理学的検査(6)多局所VEP
    石川 久美子, 長井 隆行, 中村 誠
    金原出版, Nov. 2014, 眼科, 56(12) (12), 1459 - 1464, Japanese

  • 【進化するOCT】 視神経疾患におけるOCTのトピックス
    Kanamori Akiyasu, Nakamura Makoto
    先端医学社, Oct. 2014, Retina Medicine, 3(2号) (2号), 125 - 131, Japanese
    [Invited]
    Introduction commerce magazine

  • 緑内障診療に吹く新しい風
    根木 昭, 稲谷 大, Nakamura Makoto, 福地 健郎
    Sep. 2014, Frontiers in Glaucoma, (48号) (48号), 123 - 133, Japanese
    [Invited]
    Others

  • 【視野検査の最前線】 視神経疾患・中枢性疾患の視野変化
    松本 佳子, Nakamura Makoto
    メディカル葵出版, Jul. 2014, あたらしい眼科, 31(7号) (7号), 969 - 975, Japanese
    [Invited]
    Introduction scientific journal

  • 非動脈炎性前部虚血性視神経症の基礎と臨床の現状と展望
    Nakamura Makoto
    日本眼科学会, Apr. 2014, 日本眼科学会雑誌, 118(4号) (4号), 327 - 329, Japanese
    [Invited]
    Book review

  • 【視神経症のよりよい診療】 遺伝性視神経症
    Nakamura Makoto
    Apr. 2014, OCULISTA, (13号) (13号), 41 - 50, Japanese
    [Invited]
    Introduction scientific journal

  • 【眼と遺伝】 ミトコンドリア病
    Nakamura Makoto
    金原出版, Apr. 2014, 眼科, 56(5号) (5号), 585 - 592, Japanese
    [Invited]
    Introduction scientific journal

  • ポリープ状脈絡膜血管症に対するアフリベルセプト併用光線力学的療法の6ケ月成績
    松宮亘, 本田茂, 大塚慶子, 三木明子, 長井隆行, 今井尚徳, 楠原仙太郎, 中村誠
    2014, 日本網膜硝子体学会総会プログラム・講演抄録集, 53rd

  • 【OCTのGCCマップを考える】 前部視路疾患
    Nakamura Makoto
    金原出版, Aug. 2013, 眼科, 55(8号) (8号), 927 - 932, Japanese
    [Invited]
    Introduction scientific journal

  • Optical Coherence Tomography for the Neuro-Ophthalmology Clinic
    NAKAMURA Makoto
    メディカル葵出版, 30 Jun. 2013, あたらしい眼科 = Journal of the eye, 30(6) (6), 761 - 768, Japanese

  • 【眼科薬物療法】 神経眼科疾患 遺伝性視神経症
    Nakamura Makoto
    Sep. 2012, 眼科, 54(10号) (10号), 1534 - 1540, Japanese
    [Invited]
    Introduction scientific journal

  • 【神経眼科-最新の話題】 視神経炎に抗AQP4抗体を検査すべきか?治療法は変わるか?
    Nakamura Makoto
    Jun. 2012, あたらしい眼科, 29(6号) (6号), 736 - 742, Japanese
    [Invited]
    Introduction scientific journal

  • 緑内障研究の進歩 緑内障性視神経症への挑戦 新しい病態論の提唱と他覚的機能解析方法の改良
    Nakamura Makoto, Naka Maiko, Nagai Takayuki, Kanamori Akiyasu, Yamada Yuko, Negi Akira
    (公財)日本眼科学会, Mar. 2012, 日本眼科学会雑誌, 116(3) (3), 298 - 346, Japanese
    [Refereed][Invited]
    Introduction scientific journal

  • 【22の視野異常から学ぶ 視野検査で疾患を見抜くカギ】 両耳側半盲
    Nakamura Makoto
    Mar. 2012, 眼科ケア, 14(3号) (3号), 210 - 216, Japanese
    [Invited]
    Introduction scientific journal

  • Appendix 1
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 36 - 41, Japanese

  • Principles of Treatment for Glaucoma
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 22 - 29, Japanese

  • Examination of Glaucoma
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 19 - 21, Japanese

  • Treatment for Each Type of Glaucoma
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 30 - 35, Japanese

  • Classification of Glaucoma
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 15 - 18, Japanese

  • 緑内障性視神経乳頭・網膜神経線維層変化判定ガイドライン
    相原 一, 阿部 春樹, 北澤 克明, 桑山 泰明, 酒井 寛, 白柏 基宏, 白土 城照, 鈴木 康之, 谷原 秀信, 富田 剛司, 中村 誠, 東出 朋巳, 山本 哲也, 八百枝 潔
    10 Jan. 2012, 日本眼科學会雜誌, 116(1) (1), 42 - 46, Japanese

  • Suzuki Yasuyuki, Nakamura Makoto
    (公財)日本眼科学会, Jan. 2012, 日本眼科学会雑誌, 116(1) (1), 5 - 46, Japanese
    [Invited]
    Introduction scientific journal

  • 【眼底imagingと神経眼科】 眼底imagingの問題点と限界
    Nakamura Makoto
    Sep. 2010, 神経眼科, 27巻, 3号, pp. 286-294, Japanese
    Introduction scientific journal

  • Variations in Trabeculectomy and Tips on Surgical Techniques
    KANO Kiyoshi, MORI Kazuhiko, NAKAMURA Makoto, OTORI Yasumasa
    30 Jul. 2010, 眼科手術 = Journal of ophthalmic surgery, 23(3) (3), 413 - 424, Japanese

  • 【虚血性視神経症】 非動脈炎性虚血性視神経症と緑内障性視神経症
    Nakamura Makoto
    Mar. 2010, 神経眼科, 27巻, 1号, pp. 33-40, Japanese
    Introduction scientific journal

  • 【緑内障診療 グレーゾーンを越えて】 脳脊髄液圧の影響
    Nakamura Makoto
    医学書院, Oct. 2009, 臨床眼科, 63巻, 11号, pp. 32-33(11) (11), 9 - 377, Japanese
    Introduction scientific journal

  • 【緑内障診療 グレーゾーンを越えて】 治療編 開放隅角緑内障 手術 《アンケート》 全国レクトミーマップ 線維柱帯切除術の術式アンケート調査
    Nakamura Makoto, Negi Akira
    医学書院, Oct. 2009, 臨床眼科, 63巻, 11号, pp. 316-325(11) (11), 264 - 268, Japanese
    Introduction scientific journal

  • 【緑内障の遺伝要因(内的因子)と環境要因(外的因子)】 正常眼圧緑内障
    Nakamura Makoto
    金原出版, May 2009, 眼科, 51巻, 5号, pp. 613-621(5) (5), 595 - 663, Japanese
    Introduction scientific journal

  • 緑内障性視神経症は構造障害が機能障害に先行するのか
    Nakamura Makoto
    医学書院, Mar. 2009, 臨床眼科, 63巻, 3号, pp. 261-266(3) (3), 261 - 266, Japanese
    Introduction scientific journal

  • 【「眼疾患と動物モデル」をより理解するために】 緑内障研究へのマウスの応用 眼圧および網膜神経節細胞障害機序の解明を目指して 緑内障研究におけるマウスの有用性
    Nakamura Makoto
    Mar. 2009, 日本の眼科, 80巻, 3号, pp. 289-292, Japanese
    Introduction scientific journal

  • 【糖尿病の眼合併症】 糖尿病関連視神経症
    Nakamura Makoto
    医学書院, Nov. 2008, 臨床眼科, 62巻, 12号, pp. 1836-1841(12) (12), 1810 - 1815, Japanese
    Introduction scientific journal

  • 【眼科薬物治療A to Z】 疾患別治療戦略と処方の実際 視神経・視路疾患 Leber遺伝性視神経症
    Nakamura Makoto
    Sep. 2008, 眼科プラクティス, 23巻, , pp. 244-245, Japanese
    Introduction scientific journal

  • 【眼科疾患アトラス】 緑内障 頸動脈海綿静脈洞瘻
    Nakamura Makoto
    Sep. 2008, 眼科, 50巻, 10号, pp. 1408-1409, Japanese
    Introduction scientific journal

  • 【眼科疾患アトラス】 緑内障 視神経乳頭出血
    Nakamura Makoto
    Sep. 2008, 眼科, 50巻, 10号, pp. 1450-1450, Japanese
    Introduction scientific journal

  • 【眼科疾患アトラス】 緑内障 ラミナドットサイン
    Nakamura Makoto
    金原出版, Sep. 2008, 眼科, 50巻, 10号, pp. 1451-1451(10) (10), 1269 - 1649, Japanese
    Introduction scientific journal

  • 【眼科疾患アトラス】 緑内障 Haab(ハーブ)の線条
    Nakamura Makoto
    Sep. 2008, 眼科, 50巻, 10号, pp. 1406-1406, Japanese
    Introduction scientific journal

  • 【視神経炎・視神経症アップデート】 遺伝性視神経症
    Nakamura Makoto
    金原出版, Aug. 2008, 眼科, 50巻, 8号, pp. 1031-1037(8) (8), 1031 - 1037, Japanese
    Introduction scientific journal

  • 【緑内障点眼薬 選択のポイント】 α受容体作動薬 α1遮断薬とα2刺激薬
    Nakamura Makoto
    Jun. 2008, あたらしい眼科, 25巻, 6号, pp. 771-774, Japanese
    Introduction scientific journal

  • 【小児眼科診療】 疾患特性と診療指針 神経眼科 視神経疾患
    Nakamura Makoto
    Mar. 2008, 眼科プラクティス, 20巻, , pp. 260-269, Japanese
    Introduction scientific journal

  • 新しい緑内障点眼薬
    Nakamura Makoto
    金原出版, Feb. 2008, 眼科, 50巻, 2号, pp. 183-188(2) (2), 183 - 188, Japanese
    Introduction scientific journal

  • Anti-aquaporin 4 antibody associated symptomatic narcolepsy due to hypothalamic lesions with multiple sclerosis
    T. Kanbayashi, Nakashima, I, T. Shimohata, T. Takahashi, K. Tanaka, M. Nakamura, Y. Sagawa, J. Tokunaga, M. Okuda, T. Shimizu
    2008, SLEEP, 31, A216 - A216, English
    Summary international conference

  • 【とっても身近な神経眼科】 乳頭が腫れていたら
    Nakamura Makoto
    メディカル葵出版, Dec. 2007, あたらしい眼科, 24巻, 12号, pp. 1553-1560(12) (12), 1551 - 1617, Japanese
    Introduction scientific journal

  • 【眼科専門医に必要な「全身疾患と眼」のすべて】 神経・筋肉疾患 Leber遺伝性視神経症
    Nakamura Makoto
    医学書院, Oct. 2007, 臨床眼科, 61巻, 11号, pp. 98-102(11) (11), 274 - 277, Japanese
    Introduction scientific journal

  • 【視野】 視路疾患と視野 視索・外側膝状体・視放線疾患と視野
    Nakamura Makoto
    May 2007, 眼科プラクティス, 15巻, , pp. 214-218, Japanese
    Introduction scientific journal

  • 実例で観る緑内障視神経症の形状と機能（６）偽緑内障の鑑別（虚血性視神経症）
    NAKAMURA MAKOTO
    Feb. 2007, 眼科インストラクションコース．視神経と視野による緑内障診断完全マスター, 10巻, pp. 162-165, Japanese
    Introduction scientific journal

  • 視神経乳頭形状、視神経周囲組織と視野異常の対応をどう同定するか
    NAKAMURA MAKOTO
    Feb. 2007, 眼科インストラクションコース．視神経と視野による緑内障診断完全ﾏｽﾀｰ, 10巻, pp. 138-142, Japanese
    Introduction scientific journal

  • 【緑内障診療の新しい展開】 眼圧の質のとらえ方
    NAKAMURA MAKOTO
    医学書院, Feb. 2007, 臨床眼科, 61巻, 2号, pp. 146-151(2) (2), 128 - 135, Japanese
    Introduction scientific journal

  • 緑内障手術の実践 トラベクレクトミーの実際
    NAKAMURA MAKOTO
    Dec. 2006, Frontiers in Glaucoma, 7巻, 4号, pp. 169-173, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 頭蓋内圧亢進を伴わない乳頭腫脹
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 312-312, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 前部虚血性視神経症
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 297-298, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 若年性優性遺伝性視神経萎縮
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 309-309, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 視神経網膜炎
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 300-300, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 後部虚血性視神経症
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 299-299, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 炎性視神経萎縮・網膜性視神経萎縮
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 314-314, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 エタンブトール
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 305-305, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 うっ血乳頭
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 310-311, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 SSOH
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 292-292, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 視神経 Leber遺伝性視神経症
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 308-308, Japanese
    Introduction scientific journal

  • 【眼底アトラス】 疾患アトラス 眼底疾患 網膜有髄神経線維
    NAKAMURA MAKOTO
    Nov. 2006, 眼科プラクティス, 12巻, pp. 273-273, Japanese
    Introduction scientific journal

  • 緑内障セミナー 新しい眼圧計PASCAL
    NAKAMURA MAKOTO
    Sep. 2006, あたらしい眼科, 23巻, 9号, pp. 1185-1186, Japanese
    Introduction scientific journal

  • 新しい眼圧計
    NAKAMURA MAKOTO
    医学書院, Sep. 2006, 臨床眼科, 60巻, 9号, pp. 1557-1561(9) (9), 1557 - 1561, Japanese
    Introduction scientific journal

  • 【緑内障診療の進めかた】 病型別診断と治療 発達緑内障 早発型発達緑内障 診断と管理
    NAKAMURA MAKOTO
    Sep. 2006, 眼科プラクティス, 11巻, pp. 110-112, Japanese
    Introduction scientific journal

  • 【緑内障診療の進めかた】 Topics 緑内障とcomplementary medicine
    NAKAMURA MAKOTO
    Sep. 2006, 眼科プラクティス, 11巻, pp. 285-285, Japanese
    Introduction scientific journal

  • 【緑内障診療の進めかた】 Topics 羊膜を用いた修復
    NAKAMURA MAKOTO
    文光堂, Sep. 2006, 眼科プラクティス, 11巻, pp. 333-333, 333 - 333, Japanese
    Introduction scientific journal

  • 【緑内障診療の進めかた】 One Point Advice 小児緑内障の術後視機能評価のポイント
    NAKAMURA MAKOTO
    Sep. 2006, 眼科プラクティス, 11巻, pp. 124-124, Japanese
    Introduction scientific journal

  • 【視路疾患の診かた 検査法からみた視路疾患】 形態検査による視神経乳頭部の診かた 光干渉断層計
    NAKAMURA MAKOTO
    金原出版, Sep. 2006, 眼科, 48巻, 10号, pp. 1347-1354(10) (10), 1369 - 1373, Japanese
    Introduction scientific journal

  • 緑内障セミナー 新しい眼圧計アイケア
    NAKAMURA MAKOTO
    Jul. 2006, あたらしい眼科, 23巻, 7号, pp. 893-894, Japanese
    Introduction scientific journal

  • 【続発緑内障の病態と治療】 真性小眼球症に関連した続発緑内障
    NAKAMURA MAKOTO
    Jul. 2006, 眼科手術, 19巻, 3号, pp. 305-308, Japanese
    Introduction scientific journal

  • 眼圧測定に関連した角膜上皮障害と院内感染を防ごう！
    NAKAMURA MAKOTO
    Apr. 2006, 眼科インストラクションコース．緑内障 細隙灯顕微鏡診断完全マスター, 7巻, pp. 124-127, Japanese
    Introduction scientific journal

  • Leber病の対光反応・中心フリッカー所見
    NAKAMURA MAKOTO
    Mar. 2006, 日本医事新報, 4272巻, pp. 113-113, Japanese
    Introduction scientific journal

  • 【どこまで進んだ分子病態の解明と標的治療】 緑内障性視神経症
    NAKAMURA, Makoto
    医学書院, Feb. 2006, 臨床眼科, 60巻, 2, pp.144-151(2) (2), 144 - 151, Japanese
    Introduction scientific journal

  • 【糖尿病眼合併症の診療指針】 その他の眼合併症 神経眼科的合併症 視神経症
    NAKAMURA MAKOTO
    Jan. 2006, 眼科プラクティス, 7巻, pp. 200-203, Japanese
    Introduction scientific journal

  • 目でみるシリーズ 緑内障手術の基礎知識 トラベクレクトミーの基礎(図説)
    NAKAMURA, Makoto
    Dec. 2005, Frontiers in Glaucoma, 6巻, 4, pp.185-193, Japanese
    Introduction scientific journal

  • この病気のココが知りたい 眼科編 緑内障
    NAKAMURA, Makoto
    じほう, Oct. 2005, 調剤と情報, 11巻, 11, pp.1461-1465(11) (11), 1461 - 1465, Japanese
    Introduction scientific journal

  • レーベル遺伝性視神経症の発症分子メカニズムの展望
    NAKAMURA, Makoto
    Apr. 2005, 日本眼科学会雑誌, 109巻, 4号, pp.189-196, Japanese
    [Refereed]
    Introduction scientific journal

  • 【グリア細胞 その新しい展開】 グリア細胞と脳疾患 糖尿病網膜症
    NAKAMURA, Makoto
    Feb. 2005, Clinical Neuroscience, 23巻, 2号, pp. 216-218, Japanese
    Introduction scientific journal

  • Diabetes mellitus as a risk factor for glaucomatous optic neuropathy
    NAKAMURA, Makoto, KANAMORI,Akiyasu, NEGI, Akira
    2005, Ophthalmologica. Journal International D'Ophtalmologie. International Journal Of Ophthalmology. Zeitschrift Fur Augenheilkunde, Vol. 219, No. 1, pp. 1-10, 1 - 10, English
    Introduction scientific journal

  • 【神経眼科Q&A】 視神経疾患 Leber病の原因として何を考えればいいのですか
    NAKAMURA, Makoto
    Jan. 2005, あたらしい眼科, 21巻, 臨増, pp. 65-68, 65 - 68, Japanese
    Introduction scientific journal

  • ロービジョンケア 残された視力をどう生かすか 視神経疾患とロービジョンケア
    NAKAMURA, Makoto
    Aug. 2004, 眼科ケア, 6巻, 8号, pp. 782-787, 89 - 93, Japanese
    Introduction scientific journal

  • 緑内障神経保護治療の展望
    NAKAMURA, Makoto
    医学書院, Jun. 2004, 臨床眼科, 58巻, 6号, pp. 887-891(6) (6), 887 - 891, Japanese
    Introduction scientific journal

  • 正常眼圧緑内障
    NAKAMURA, Makoto, NEGI, Akira
    Jun. 2004, 日本医事新報, 4180号, pp. 19-24, Japanese
    Introduction scientific journal

  • 【眼科疾患別パーフェクト検査マニュアル】 疾患別検査の進め方 乳幼児の視機能を把握する
    NAKAMURA, Makoto, 調廣子
    Dec. 2003, 眼科ケア, 2003年冬季増刊, pp. 206-215, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 毛様体扁平部濾過手術の適応と実際
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 190-190, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 トラベクロトミー 乳幼児の場合のポイント
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 155-156, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 トラベクレクトミー 羊膜を使った濾過胞修復
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 180-181, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 トラベクレクトミー 術中虹彩切開部からの出血
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 162-162, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 トラベクレクトミー 術後,胞状脈絡膜剥離,大量脈絡膜滲出,網膜出血,中心静脈閉塞症
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 172-172, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 手術治療 トラベクレクトミー 各種結膜縫合法の実際
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 163-163, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 治療方針 病型別-水晶体関連 先天白内障術後の高眼圧
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 87-87, Japanese
    Introduction scientific journal

  • 【緑内障診療のトラブルシューティング】 治療方針 病型別-水晶体関連 小児の球状水晶体に伴う高眼圧
    NAKAMURA, Makoto
    Sep. 2003, 眼科診療プラクティス, 98巻, pp. 87-87, Japanese
    Introduction scientific journal

  • 【スタンダード眼科顕微鏡手術】 緑内障手術 トラベクロトミー
    NAKAMURA, Makoto
    Jul. 2003, 眼科診療プラクティス, 96巻, pp. 152-158, Japanese
    Introduction scientific journal

  • 【スタンダード眼科顕微鏡手術】 緑内障手術 トラベクレクトミー
    NAKAMURA, Makoto, NEGI, Akira
    Jul. 2003, 眼科診療プラクティス, 96巻, pp. 144-151, Japanese
    Introduction scientific journal

  • Low-Vision Care for Patients with Leber's Hereditary Optic Neuropathy : Report on Junior High and High School Students
    MORI Yumiko, ISHIBASHI Kazki, NAKAMURA Makoto, SEKIYA Yoshibumi
    28 Dec. 2002, 日本眼科紀要 = Folia ophthalmologica Japonica, 53(12) (12), 991 - 994, Japanese

  • A statistical survey on ocular motility disturbances in ophthalmic clinic of Kobe University
    KANAMORI Akiyasu
    09 Oct. 2001, 抄録集, 18, 111 - 111, Japanese

  • Multifocal Visual Evoked Potentials with Bipolar Occipital Straddle Electrodes(2) : Effect of Stimulus Contrast on Latency and Amplitude
    ENO Ayako, NAKAMURA Makoto, NEGI Akira
    28 Aug. 2000, 日本眼科紀要 = Folia ophthalmologica Japonica, 51(8) (8), 734 - 738, Japanese

  • Hidetaka Maeda, Ayako Eno, Makoto Nakamura, Akira Negi
    2000, Eye, 14(5) (5), 802 - 804, English
    Report scientific journal

  • A New Rapid, Perimetry Test with Dynamic Strategy and a Tendency Oriented Program (TOP) to Detect Glaucoma
    MAEDA Hidetaka, NAKAMURA Makoto
    28 Sep. 1999, 日本眼科紀要 = Folia ophthalmologica Japonica, 50(9) (9), 715 - 720, Japanese

  • Morphometric Features in the Lamina Cribrosa Observed by a Scanning Laser Ophthalmoscope
    MAEDA Hidetaka, NAKAMURA Makoto, YAMAMOTO Misao
    10 Jan. 1999, 日本眼科學会雜誌, 103(1) (1), 48 - 55, Japanese

  • Distribution of Retinal Sensitivity with Blue on Yellow Perimetry in Ocular Hypertension
    MAEDA Hidetaka, TANAKA Yoshiaki, SUGIURA Torao, NAKAMURA Makoto, YAMAMOTO Misao
    10 Feb. 1998, 日本眼科學会雜誌, 102(2) (2), 111 - 116, Japanese

  • Multifocal Electroretinogram Characteristics of Optic Nerve Disorders
    NAKAMURA Makoto, SENO-O Kenji, TAGUCHI Kohji, FUJII Shigeki, SEKIYA Yoshibumi
    28 Jul. 1997, 日本眼科紀要 = Folia ophthalmologica Japonica, 48(7) (7), 845 - 850, Japanese

  • A Case of Probably Unilateral Leber's Hereditary Optic Neuropathy with Visual Recovery
    OGIYA Nobuaki, NAKAMURA Makoto, SEKIYA Yoshifumi
    30 Oct. 1995, あたらしい眼科 = Journal of the eye, 12(10) (10), 1636 - 1638, Japanese

■ Books And Other Publications
  • Leber遺伝性視神経症の発症メカニズム 遺伝、症状、治療に関して教えてください / あたらしい眼科36巻 臨時増刊号
    上田 香織, 中村 誠
    Joint work, メディカル葵出版, Nov. 2019

  • レーベル遺伝性視神経症 (Leber Hereditary Optic Neuropathy ; LHON) / 眼疾患アトラスシリーズ第2巻 後眼部アトラス
    上田 香織, 中村 誠
    Joint work, 総合医学社, Oct. 2019

  • 視路疾患におけるOCTの活用法 / 眼科グラフィック8巻4号 「超」入門神経眼科診療
    上田 香織, 中村 誠
    Joint work, メディカ出版, Jul. 2019

  • 未承認薬・適応外使用薬と研究倫理 / 緑内障道場
    中村 誠
    Others, 医学書院, Apr. 2019

  • 両耳側半盲（下垂体腺腫）/ 眼科疾患 最新の治療2019-2021
    中村 誠
    Others, 南江堂, Mar. 2019

  • 眼科疾患と薬物治 薬物治療学
    芥子 結香子, 中村 誠
    化学同人, 2019, Japanese, ISBN: 9784759816297

  • Leber遺伝性視神経症の発症メカニズム / 神経眼科36巻2号 別冊
    上田 香織, 中村 誠
    Joint work, 日本神経眼科学会, 2019

  • 標準眼科学第14版 / 第16章 神経眼科
    Nakamura Makoto
    Others, 医学書院, Dec. 2018, Japanese
    Textbook

  • 緑内障診療ガイドライン解説 緑内障診療テキスト / 正常眼圧緑内障
    芥子由結子, Nakamura Makoto
    Others, 南江堂, May 2018, Japanese
    Scholarly book

  • 緑内障診療ガイドライン解説 緑内障診療テキスト / 小児緑内障
    山田裕子, Nakamura Makoto
    Others, 南江堂, May 2018, Japanese
    Scholarly book

  • 緑内障診療ガイドライン解説 緑内障診療テキスト / 原発開放隅角緑内障
    Nakamura Makoto
    Others, 南江堂, May 2018, Japanese
    Scholarly book

  • 1336専門家による私の治療 2017-18年度版 / 視神経萎縮
    松本佳子, Nakamura Makoto
    Others, 日本医事新報社, May 2017, Japanese
    Scholarly book

  • 眼底疾患パーフェクトアトラス / 視路疾患による逆行性視神経萎縮
    Nakamura Makoto
    Others, 文光堂, Mar. 2017, Japanese
    Scholarly book

  • 小児科診断・治療指針 改定第二版 / 緑内障
    Nakamura Makoto
    Others, 中山書店, Feb. 2017, Japanese
    Scholarly book

  • 今日の治療指針 2017 / 視神経炎
    Nakamura Makoto
    Others, 医学書院, Jan. 2017, Japanese
    Scholarly book

  • 前視野緑内障に向き合う / 前視野緑内障の治療の流れ（総論）
    Nakamura Makoto
    Others, 文光堂, Oct. 2016, Japanese
    Scholarly book

  • 眼科検査ガイド第二版 / 多局所視覚誘発電位
    Nakamura Makoto
    Others, 文光堂, Sep. 2016, Japanese
    Scholarly book

  • 眼科臨床エキスパート．知っておきたい神経眼科診療 / Leber遺伝性視神経症
    Nakamura Makoto
    Others, 医学書院, Apr. 2016, Japanese
    Scholarly book

  • 専門医のための眼科診療クオリファイ 30.眼の発生と解剖・機能 / 中枢神経（III～VIII）
    Nakamura Makoto
    Others, 中山書店, Mar. 2016, Japanese
    Scholarly book

  • 眼科疾患 最新の診療2016-2018 / 視神経炎
    Nakamura Makoto
    Others, 南江堂, Feb. 2016, Japanese
    Scholarly book

  • 眼科臨床エキスパート．緑内障治療のアップデート． / トラベクロトミーのコツと落とし穴
    Nakamura Makoto
    Others, 医学書院, Oct. 2015, Japanese
    Textbook

  • 眼科臨床エキスパート．緑内障治療のアップデート / 隅角癒着乖離術
    Nakamura Makoto
    Others, 医学書院, Oct. 2015, Japanese
    Textbook

  • 視神経乳頭・視野でみる緑内障確定診断 / 緑内障以外の乳頭陥凹―視神経部分低形成
    Nakamura Makoto
    Others, メジカルビュー社, Sep. 2015, Japanese
    Scholarly book

  • 視神経乳頭・視野でみる緑内障確定診断 / 緑内障以外の乳頭陥凹―虚血性変化後
    Nakamura Makoto
    Others, メジカルビュー社, Sep. 2015, Japanese
    Scholarly book

  • 視神経乳頭・視野でみる緑内障確定診断 / 緑内障以外の乳頭陥凹―その他の視神経症
    Nakamura Makoto
    Others, メジカルビュー社, Sep. 2015, Japanese
    Scholarly book

  • 今日の診断指針 / 特発性視神経炎
    Nakamura Makoto
    Others, 医学書院, Mar. 2015, Japanese
    Scholarly book

  • 今日の治療指針 / 眼外傷
    Nakamura Makoto
    Others, 医学書院, Jan. 2015, Japanese
    Scholarly book

  • 神経眼科診断クローズアップ / 視野ー緑内障と間違えやすい視野異常
    Nakamura Makoto
    Others, メジカルビュー, Nov. 2014, Japanese
    Scholarly book

  • 緑内障診療クローズアップ / 緑内障患者に使えない薬
    Nakamura Makoto
    Others, メジカルビュー, Apr. 2014, Japanese
    Scholarly book

  • 緑内障診療クローズアップ / 妊婦、小児への点眼薬処方
    Nakamura Makoto
    Others, メジカルビュー, Apr. 2014, Japanese
    Scholarly book

  • 緑内障診療クローズアップ / 正常眼圧緑内障 概論
    Nakamura Makoto
    Others, メジカルビュー, Apr. 2014, Japanese
    Scholarly book

  • All about 原発閉塞隅角緑内障 / 眼圧測定の注意点
    Nakamura Makoto
    Others, 医学書院, Apr. 2014, Japanese
    Scholarly book

  • All About 開放隅角緑内障 / ガイドラインに準拠した薬物治療の考え方
    Nakamura Makoto
    Others, 医学書院, Apr. 2013, Japanese
    Scholarly book

  • 専門医のための眼科診療クオリファイ16. 糖尿病眼合併症の新展開 / 糖尿病関連視神経症
    Nakamura Makoto
    Others, 中山書店, Feb. 2013, Japanese
    Scholarly book

  • 専門医のための眼科診療クオリファイ15. メデイカルオフサルモロジー 眼薬物治療のすべて / Leber 遺伝性視神経症
    Nakamura Makoto
    Others, 中山書店, Dec. 2012, Japanese
    Scholarly book

  • 最新ガイドライン準拠 小児科診断・治療指針 / 緑内障
    Nakamura Makoto
    Others, 中山書店, Sep. 2012, Japanese
    Scholarly book

  • 眼手術学 6.緑内障 / 結膜瘢痕化
    Nakamura Makoto
    Others, 文光堂, 2012, Japanese
    Textbook

  • 専門医のための眼科診療クオリファイ．3 緑内障診断ガイド / 緑内障性視野異常と鑑別疾患
    Nakamura Makoto
    Joint work, 中山書店, Feb. 2011, Japanese
    Scholarly book

  • 専門医のための眼科診療クオリファイ 7.視神経疾患のすべて / 視神経周囲炎
    Nakamura Makoto
    Joint work, 中山書店, 2011, Japanese
    Scholarly book

  • 眼科学第二版 / 小児の緑内障
    Nakamura Makoto
    Joint work, 文光堂, 2011, Japanese
    Textbook

  • 眼科検査のグノーテイ・セアウトン / 視野のスコア分類は、日常診療に適用すべきなのか？
    Nakamura Makoto
    Joint work, シナジー, Nov. 2010, Japanese
    Scholarly book

  • 眼科検査のグノーテイ・セアウトン / 眼圧測定の使い捨てプリズムは、何を用いても構わないのか？
    Nakamura Makoto
    Joint work, シナジー, Nov. 2010, Japanese
    Scholarly book

  • 眼のサイエンス．眼疾患の謎 / Leber遺伝性視神経症はなぜ浸透率が低いのか、どうして環境因子が関係するのか？
    Nakamura Makoto
    Joint work, 文光堂, Jun. 2010, Japanese
    Scholarly book

  • 今日の治療指針 / 虚血性視神経症
    Nakamura Makoto
    Joint work, 医学書院, 2010, Japanese
    Scholarly book

  • 今日の治療指針．私はこう治療している / 虚血性視神経症
    Nakamura Makoto
    Joint work, 医学書院, 2009, Japanese
    Scholarly book

  • 眼科診療のコツと落とし穴３．検査・診断． / 画像解析装置を応用するときの注意点
    Nakamura Makoto
    Joint work, 中山書店, 2008, Japanese
    Scholarly book

  • 眼科プラクティス23．眼科薬物治療A to Z． / Leber遺伝性視神経症
    Nakamura Makoto
    Joint work, 文光堂, 2008, Japanese
    Scholarly book

  • 眼科プラクティス20．小児眼科診療 / 視神経疾患
    Nakamura Makoto
    Joint work, 文光堂, 2008, Japanese
    Scholarly book

  • 眼科インストラクションコース17. 眼科診療のスキルアップ / 正常眼圧緑内障の目標眼圧設定の実際は？ 設定値変化はどうするか？
    Nakamura Makoto
    Joint work, メジカルビュー社, 2008, Japanese
    Scholarly book

  • 眼科インストラクションコース14. トラベクレクトミー完全マスター． / 術翌日の診察ではここに注意しておこう！
    Nakamura Makoto
    Joint work, メジカルビュー社, 2008, Japanese
    Scholarly book

  • すぐに役立つ眼科診療の知識．臨床神経眼科学 / 同名半盲に合併したRAPD
    Nakamura Makoto
    Joint work, 金原出版, 2008, Japanese
    Scholarly book

  • すぐに役立つ眼科診療の知識．臨床神経眼科学 / 虚血性視神経症の治療
    Nakamura Makoto
    Joint work, 金原出版, 2008, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 乳頭部第一次硝子体過形成遺残
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 乳頭周囲ぶどう腫
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 糖尿病と視神経萎縮
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 朝顔症候群
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 先天乳頭上膜，Bergmeister乳頭遺残
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 視神経・視路疾患．コロボーマ
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 屈折異常と視神経乳頭
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二版 / 虚血性視神経症
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 今日の眼疾患治療指針．第二 / 視神経萎縮
    Nakamura Makoto
    Joint work, 医学書院, 2007, Japanese
    Scholarly book

  • 眼科インストラクションコース14. トラベクレクトミー完全マスター / 術翌日の診察ではここに注意しておこう！
    Nakamura Makoto
    Joint work, メジカルビュー社, 2007, Japanese
    Scholarly book

  • 緑内障と眼の病気 / 緑内障性障害の病因
    Nakamura Makoto
    Joint translation, メデイカルビュー社, Oct. 2006, Japanese
    Scholarly book

  • 緑内障３分診療を科学する！ / 前眼部の発達・構造異常を伴う緑内障
    NAKAMURA MAKOTO
    Joint work, 中山書店, Sep. 2006, Japanese
    Scholarly book

  • 緑内障と眼の病気 / 緑内障の危険因子、緑内障性障害の病因
    NAKAMURA MAKOTO
    Joint translation, メディカルレビュー, 2006, Japanese
    Scholarly book

  • 眼科プラクティス7巻 糖尿病眼合併症の診療指針 / その他の眼合併症 神経眼科的合併症 視神経症
    NAKAMURA, Makoto
    Joint work, 文光堂, Jan. 2006, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / 視路の異常 視神経の病変 視神経周囲炎
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / 視路の異常 視神経の病変 遺伝性視神経症
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / One Point Advice 近視眼にみられる乳頭出血
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / One Point Advice RAPDの定量とparadoxical RAPD
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / Controversy テンシロンテストvsアイスパックテスト
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

  • 眼科プラクティス5巻 これならわかる神経眼科 / Advanced Techniques 髄液検査の有用性と意義
    NAKAMURA, Makoto
    Joint work, 文光堂, Sep. 2005, Japanese
    Scholarly book

■ Lectures, oral presentations, etc.
  • Alport症候群に伴う網膜異常に対する微小視野計（MP3）を用いた機能的評価
    金 景佑, 楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 経過中に脈絡膜変化を伴った妊娠高血圧症候群に続発した高血圧性脈絡膜症の1症例
    酒井 大輝, 松宮 亘, 楠原 仙太郎, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 自己免疫網膜症疑い患者の臨床的特徴
    西庄 龍東, 楠原 仙太郎, 金 景佑, 勝山 敦子, 松宮 亘, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 視力良好な中心性漿液性脈絡網膜症における治療後不等像視の関連因子についての検討
    林田 真由香, 三木 明子, 島内 深希, 中井 駿一朗, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 視力良好なポリープ状脈絡膜血管症に対する硝子体注射併用光線力学的療法の1年経過
    中井 駿一朗, 三木 明子, 松宮 亘, 林田 真由香, 本田 茂, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 網膜中心静脈閉塞症に対する抗VEGF薬・ステロイド・周辺網膜光凝固併用療法
    勝山 敦子, 楠原 仙太郎, 金 景佑, 西庄 龍東, 松宮 亘, 中村 誠
    第58回日本網膜硝子体学会, Dec. 2019, Japanese, Domestic conference
    Poster presentation

  • 両眼開放下視野測定により診断した片眼性心因性視覚障害の2例
    土橋 一生, 盛 崇太朗, 中西 裕子, 上田 香織, 坂本 麻里, 栗本 拓治, 中村 誠
    兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference
    Oral presentation

  • 毛様溝挿入バルベルトインプラント手術の術後中長期成績
    曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference
    Oral presentation

  • フルコナゾール全身投与が効果不良であったCandida albicansによる真菌性眼内炎の1例
    高野 史生, 鉄本 章, 今井 尚徳, 中村 誠
    兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference
    Oral presentation

  • 増殖硝子体網膜症を伴った水晶体起因性眼内炎の一例
    井上 紗季, 鉄本 章, 大塚 慶子, 今井 尚徳, 中村 誠
    兵庫県眼科医会・2大学合同オープンカンファレンス, Nov. 2019, Japanese, Domestic conference
    Oral presentation

  • Clinical factors associated with aniseikonia after reduced-fluence photodynamic therapy in central serous chorioretinopathy patients with good visual acuity.
    Mayuka Hayashida, Akiko Miki, Syunichiro Nakai, Makoto Nakamura
    13th Asia-Pacific Vitreo-retina Society, Nov. 2019, English, International conference
    Poster presentation

  • The size of the gauge and the cross-sectional area of the shaft are factors that determine the aspiration volume of the backflush needle.
    Akira Tetsumoto, Hisanori Imai, Makoto Nakamura
    13th Asia-Pacific Vitreo-retina Society, Nov. 2019, English, International conference
    Poster presentation

  • 緑内障診療におけるOCT：多事争論！
    中村 誠
    SENJU Ophthalmic Seminar in 松江, Nov. 2019, Japanese
    Public discourse

  • Short-term outcomes of Tenon’s capsule retractor-assisted trabeculectomy for uveitic glaucoma.
    Sentaro Kusuhara, Makoto Nakamura
    15th International Ocular Inflammation Society Congress, Nov. 2019, English, International conference
    Oral presentation

  • 視力良好な網膜静脈分枝閉塞症に伴う黄斑浮腫に対する抗VEGF治療成績
    金 景佑, 楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 中心性漿液性脈絡網膜症に対する低照射エネルギー光線力学療法の長期治療成績
    林田 真由香, 三木 明子, 島内 深希, 中井 駿一朗, 大塚 慶子, 松宮 亘, 今井 尚徳, 楠原 仙太郎, 和田 友紀, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Poster presentation

  • 新規ブリモニジン/チモロール配合点眼剤のチモロール対照第III相比較試験
    中村 誠, 新家 眞, 関谷 卓郎
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • ぶどう膜炎における超広角眼底自発蛍光の特徴
    楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 毛様溝挿入バルベルトインプラント手術の術後中長期成績
    曽谷 尭之, 盛 崇太朗, 村井 佑輔, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 緑膿菌が原因の結膜炎から結膜欠損を引き起こした免疫健常な若年例
    山田 裕子, 上田 香織, 長井 隆行, 中西 裕子, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Poster presentation

  • 卵黄様黄斑症を伴う眼内リンパ腫の臨床的特徴の検討
    松宮 亘, 林田 真由香, 三木 明子, 今井 尚徳, 楠原 仙太郎, 中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • インストラクションコース23 斜視・弱視・小児眼科・神経眼科 やさしい神経眼科 vol.9
    中村 誠
    第73回日本臨床眼科学会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 多発血管炎性肉芽腫症に伴う副鼻腔炎により発症した両側鼻性視神経症の一例
    村井 佑輔, 栗本 拓治, 河原 佳奈, 山田 裕子, 盛 崇太朗, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 抗PD-L1抗体薬により視神経炎と下垂体機能低下症を来した一例
    山田 裕子, 栗本 拓治, 上田 香織, 村井 祐輔, 盛 崇太朗, 坂本 麻里, 中西 裕子, 中村 誠
    第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 再発性視神経炎に対する免疫抑制剤の治療効果
    盛 崇太朗, 栗本 拓治, 村井 祐輔, 上田 香織, 坂本 麻里, 千原 典夫, 中西 裕子, 中村 誠
    第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • ランチョンセミナー1 視神経疾患と緑内障を見極める 緑内障と紛らわしい鑑別疾患
    中村 誠
    第57回日本神経眼科学会総会, Oct. 2019, Japanese, Domestic conference
    Oral presentation

  • 視力良好な糖尿病黄斑浮腫に対する抗VEGF薬硝子体注射の12ヵ月治療成績
    楠原 仙太郎, 勝山 敦子, 松宮 亘, 中村 誠
    第34回日本糖尿病合併症学会・第25回日本糖尿病眼学会総会, Sep. 2019, Japanese, Domestic conference
    Oral presentation

  • 緑内障マネージメントのアップデート
    中村 誠
    なんかい眼科フォーラム, Sep. 2019, Japanese
    Public discourse

  • ランチョンセミナー7 緑内障トリビア3 神経眼科
    中村 誠
    第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference
    Oral presentation

  • シンポジウム6 超高齢社会の緑内障のマネージメント 加齢変化と緑内障の関係
    中村 誠
    第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference
    Oral presentation

  • Effectiveness of the intentional lamellar macular hole formation for the treatment of refractory cystoid macular edema
    Akira Tetsumoto, Hisanori Imai, Mayuka Hayashida, Keiko Otsuka, Akiko Miki, Makoto Nakamura
    19th Euretina Congress, Sep. 2019, English, International conference
    Poster presentation

  • 毛様溝挿入アーメドインプラント手術の術後短期成績
    村井 佑輔, 盛 崇太朗, 栗本 拓治, 山田 裕子, 上田 香織, 坂本 麻里, 中西 裕子, 中村 誠
    第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference
    Oral presentation

  • データ解析委員会特別セッション～研究プロジェクト支援事業～ Trabectomeに対する、microhookを用いた線維柱帯切開術眼内法の眼圧下降効果と安 全性の非劣性を検討する多施設共同ランダム化介入臨床研究
    中村 誠
    第30回日本緑内障学会, Sep. 2019, Japanese, Domestic conference
    Oral presentation

  • The comparison of reduced fluence photodynamic therapy with modified or conventional irradiation area for central serous chorioretinopathy.
    Mayuka Hayashida, Akiko Miki, Hisanori Imai, Shigeru Honda, Makoto Nakamura
    19th Euretina Congress, Sep. 2019, English, International conference
    Poster presentation

  • 神経眼科の緊急疾患
    中村 誠
    第77回日本眼科医会生涯教育講座 眼科における緊急疾患, Aug. 2019, Japanese
    Public discourse

  • 視路疾患診療最前線！
    中村 誠
    第6回Tokai Ophthalmic Academy, Aug. 2019, Japanese
    Public discourse

  • 女性医師支援の歩みと課題
    中村 誠
    医学系女性研究者・女性医師の活躍促進のための意見交換会, Jul. 2019, Japanese
    Public discourse

  • 神経眼科の緊急疾患
    中村 誠
    第77回日本眼科医会生涯教育講座 眼科における緊急疾患, Jul. 2019, Japanese
    Public discourse

  • 神経眼科の緊急疾患
    中村 誠
    第77回日本眼科医会生涯教育講座 眼科における緊急疾患, Jul. 2019, Japanese
    Public discourse

  • 脈絡膜網膜炎をきたした梅毒性ぶどう膜炎3例の光干渉断層計画像所見
    勝山 敦子, 松宮 亘, 金 景佑, 西庄 龍東, 楠原 仙太郎, 中村 誠
    第56回日本眼感染症学会・第53回眼炎症学会, Jul. 2019, Japanese, Domestic conference
    Oral presentation

  • 抗PD-1抗体ペムブロリズマブ投与中に網膜血管炎を発症した1例
    金 景佑, 楠原 仙太郎, 西庄 龍東, 勝山 敦子, 松宮 亘, 中村 誠
    第56回日本眼感染症学会・第53回眼炎症学会, Jul. 2019, Japanese, Domestic conference
    Oral presentation

  • 非感染性ぶどう膜炎におけるアダリムマブ治療前後の脈絡膜構造指標変化の検討
    西庄 龍東, 楠原 仙太郎, 勝山 敦子, 松宮 亘, 中村 誠
    第56回日本眼感染症学会・第53回眼炎症学会, Jul. 2019, Japanese, Domestic conference
    Oral presentation

  • Optical coherence tomography in vitreoretinal lymphoma with or without vitelliform submaculopathy.
    Wataru Matsumiya, Mayuka Hayashida, Ryuto Nishisyo, Akira Tetsumoto, Atsuko Katsuyama, Akiko Miki, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    Global Ocular Inflammation Workshop 2019, Jun. 2019, English
    Poster presentation

  • 強直性脊椎炎加療中に発症した網膜外層障害を伴うぶどう膜炎の診断に全視野網膜電図が有用であったと思われる一例
    勝山 敦子, 松宮 亘, 金 景佑, 西庄 龍東, 楠原仙太郎, 中村 誠
    第67回日本視覚電気生理学会, Jun. 2019, Japanese
    Oral presentation

  • En face slab imaging を用いた後期緑内障眼の構造と機能の解析
    坂本 麻里, 盛崇太朗, 上田 香織, 栗本 拓治, 中西 裕子, 中村 誠
    第8回日本視野画像学会学術集会, May 2019, Japanese
    Oral presentation

  • シンポジウム2 視野の臨床を語る 視路疾患の視野
    中村 誠
    第8回日本視野画像学会学術集会, May 2019, Japanese
    Nominated symposium

  • 眼疾患患者のQOV評価の現状と課題
    中村 誠
    ケーラボ提携講演会, May 2019, Japanese
    Public discourse

  • Deletion of Aqp9 in mice enhances retinal ganglion cell death after optic nerve injury.
    Sotaro Mori, Takuji Kurimoto, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, May 2019, English
    Poster presentation

  • Predictive factors for metamorphopsia after reduced-fluence photodynamic therapy.
    Mayuka Hayashida, Akiko Miki, Miki Shimauchi, Shunichiro Nakai, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Yuki Wada, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, May 2019, Japanese
    Poster presentation

  • Genetic factors associated with the treatment response to reduced-flurence photodynamic therapy for chronic central serous chorioretinopathy.
    Akiko Miki, Mayuka Hayashida, Shunichiro Nakai, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, May 2019, English
    Poster presentation

  • The relationship between structural change of distinct retinal layers and visual prognosis in patients with macular edema secondary to branchial retinal vein occlusion.
    Atsuko Katsuyama, Sentaro Kusuhara, Ryuto Nisisho, Wataru Matsumiya, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, Apr. 2019, English
    Poster presentation

  • Post-treatment change of choroidal structural parameters and their correlations and fluctuations in Vogt-Koyanagi-Harada disease.
    Ryuto Nishisho, Wataru Matsumiya, Atsuko Katsuyama, Akihito Uji, Sentaro Kusuhara, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, Apr. 2019, English
    Poster presentation

  • The relationship between the choroidal structure and choroidal thickening in Vogt-Koyanagi-Harada disease.
    Wataru Matsumiya, Ryuto Nishisho, Atsuko Katsuyama, Akihito Uji, Sentaro Kusuhara, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, Apr. 2019, English
    Poster presentation

  • The association of the branching vascular network area progression with the outcomes of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy for polypoidal choroidal vasculopathy
    Shunichiro Nakai, Wataru Matsumiya, Mayuka Hayashida, Akiko Miki, Shigeru Honda, Makoto Nakamura
    The Association for Research in Vision and Ophthalmology, Apr. 2019, English
    Poster presentation

  • Pretreatment factors in managing protocol with aflibercept in patients with diabetic macular edema.
    Saori Tanaka, Noriko Miyamoto, Sentaro Kusuhara, Hisashi Iwami, Shogo Yamamoto, Shin Yoshitake, Yushi Hirota, Makoto Nakamura, Masahiro Ikeda, Fumi Gomi, Yasuo Kurimoto
    The Association for Research in Vision and Ophthalmology, 2019, English
    Poster presentation

  • フマル酸ジメチル／モノメチルによる視神経挫滅後の網膜神経節細胞の生存促進効 果
    盛崇太朗, 栗本 拓治, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Oral presentation

  • 前眼部OCTにより鑑別を行った結膜粘液腫の一例
    山田 裕子, 長井 隆行, 中井駿一朗, 坂本 麻里, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • 視力良好な中心性漿液性脈絡網膜症における治療後歪視の予測因子についての検討
    林田真由香, 三木 明子, 島内 深希, 中井駿一朗, 松宮 亘, 今井 尚徳, 楠原仙太郎, 和田 友紀, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • 網膜静脈分枝閉塞症に伴う黄斑浮腫における網膜最内層／内層／外層障害と視力予後の 評価
    勝山 敦子, 楠原仙太郎, 西庄 龍東, 松宮 亘, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Oral presentation

  • Vogt-小柳-原田病治療経過中の脈絡膜再肥厚と脈絡膜構造変化の検討
    松宮 亘, 西庄 龍東, 勝山 敦子, 宇治 彰人, 楠原仙太郎, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Oral presentation

  • OCTによる上方視神経部分低形成の診断の試み
    金森 章泰, 若林 星太, 金森 敬子, 盛崇太朗, 栗本 拓治, 中西 裕子, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • 糖尿病性黄斑浮腫に対するアフリベルセプト治療に影響する因子についての検討
    田中 沙織, 宮本 紀子, 楠原仙太郎, 岩見 久司, 山本 庄吾, 吉武 信, 廣田 勇士, 本田 茂, 中村 誠, 池田 誠宏, 五味 文, 栗本 康夫
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • マイクロパルス波経強膜毛様体光凝固の使用経験
    村井 佑輔, 盛崇太朗, 上田 香織, 坂本 麻里, 栗本 拓治, 中西 裕子, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • Vogt-小柳-原田病治療前後の脈絡膜構造指標の変化と相関
    西庄 龍東, 松宮 亘, 勝山 敦子, 宇治 彰人, 楠原仙太郎, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • 難治性黄斑浮腫に対する嚢胞内壁穿破術の有効性
    鉄本 章, 今井 尚徳, 林田真由香, 大塚 慶子, 三木 明子, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Oral presentation

  • ポリープ状脈絡膜血管症へのaflibercept併用光線力学的療法と異常血管網の進展
    中井駿一朗, 松宮 亘, 林田真由香, 三木 明子, 本田 茂, 中村 誠
    第123回日本眼科学会総会, Apr. 2019, Japanese
    Poster presentation

  • A comparison of one-year surgical outcome between trabeculotomy ab externo and microhook ab interno trabeculotomy using the propensity score analysis.
    Sotaro Mori, Mari Sakamoto, Kaori Ueda, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura
    World Glaucoma Congress 2019, Mar. 2019, English
    Poster presentation

  • Structure-function relationship in the temporal raphe region. Japan Glaucoma Society Symposium. Hot topics of imaging for glaucoma diagnosis and management.
    Makoto Nakamura
    World Glaucoma Congress 2019, Mar. 2019, English
    Oral presentation

  • 視神経疾患診療アップデート
    中村 誠
    新・眼科診療アップデートセミナー2019 in Kyoto, Mar. 2019, Japanese
    Public discourse

  • 神経眼科診療、知っておくべき10の知識
    中村 誠
    SENJU Ophthalmic seminar in Kyoto, Mar. 2019, Japanese
    Public discourse

  • 緑内障マネージメントのアップデート
    中村 誠
    SENJU 眼疾患セミナー in 金沢, Mar. 2019, Japanese
    Public discourse

  • 緑内障と偽緑内障の鑑別ポイント＋α
    中村 誠
    第3回Ochanomizu Crossover Conference, Mar. 2019, Japanese
    Public discourse

  • 続発緑内障に対するテノン開創器を用いた線維柱帯切除術の臨床経過
    楠原仙太郎, 中村 誠
    第38回神戸市立医療センター中央市民病院・ 神戸アイセンター病院眼科オープンカンファレンス, Mar. 2019, Japanese
    Oral presentation

  • 緑内障・視神経疾患患者の病診連携
    中村 誠
    兵庫区眼科医会パンジーの会, Feb. 2019, Japanese
    Public discourse

  • 視路疾患診療最前線！
    中村 誠
    第428回大阪眼科集談会, Jan. 2019, Japanese, Domestic conference
    Public discourse

  • 滲出型加齢黄斑変性の固視に関する検討
    林田 真由香, MIKI AKIKO, 中井 駿一朗, MATSUMIYA WATARU, IMAI HISANORI, KUSUHARA SENTARO, NAKAMURA MAKOTO
    第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conference
    Oral presentation

  • 片眼の動眼神経麻痺と僚眼の外転神経麻痺を呈したサルコイドーシスの1例
    盛 崇太朗, SAKAMOTO MARI, 上田 香織, KURIMOTO TAKUJI, NAKANISHI YUKO, NAKAMURA MAKOTO
    第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例
    佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花久嗣, NAKAMURA MAKOTO
    第56回日本神経眼科学会総会, Dec. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • ポリープ状脈絡膜血管症へのaflibercept単独療法とaflibercept併用光線力学的療法との2年経過の比較
    中井 駿一朗, MATSUMIYA WATARU, 本田 茂, 林田 真由香, MIKI AKIKO, 安積 淳, NAKAMURA MAKOTO
    第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conference
    Oral presentation

  • OCT angiographyを用いた糖尿病網膜症発症前後の網膜微小血管及び網膜構造変化の解析
    MATSUMIYA WATARU, 山崎 悠佐, 宇治 彰人, 松塲 眞弓, NAKAMURA MAKOTO
    第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conference
    Oral presentation

  • En face slab OCT像を用いた網膜静脈分枝閉塞症の乳頭黄斑線維束障害についての検討
    勝山 敦子, KUSUHARA SENTARO, 西庄 龍東, MATSUMIYA WATARU, NAKAMURA MAKOTO
    第57回日本網膜硝子体学会総会, Dec. 2018, Japanese, 京都, Domestic conference
    Oral presentation

  • 当院における悪性黒色腫の長期経過
    橋本 祐子, 中井 駿一朗, 明石 梓, SAKAMOTO MARI, NAGAI TAKAYUKI, NAKAMURA MAKOTO
    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 当院における悪性黒色腫の長期経過
    橋本 祐子, 中井 駿一朗, SAKAMOTO MARI, NAGAI TAKAYUKI, 安積 淳, NAKAMURA MAKOTO
    第36回日本腫瘍学会, Nov. 2018, Japanese, 金沢, Domestic conference
    Oral presentation

  • 髄膜炎を伴う続発性眼窩炎症と強膜炎を呈した汎発性帯状疱疹の一例
    佐々木 信之, SAKAMOTO MARI, KURIMOTO TAKUJI, 盛 崇太朗, 上田 香織, NAKANISHI YUKO, 飯島 健太, 立花 久嗣, NAKAMURA MAKOTO
    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 下垂体茎断裂症候群に対するホルモン治療中に進行性の網膜変性症の合併を認めた１症例
    金 景佑, MATSUMIYA WATARU, 勝山 敦子, KUSUHARA SENTARO, NAKAMURA MAKOTO
    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • ランゲルハンス細胞組織球症による視神経症と外転神経麻痺を来した 1 例
    山田 裕子, KURIMOTO TAKUJI, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, 中井 友昭, 魚住 洋一, 豊田 晶徳, NAKANISHI YUKO, NAKAMURA MAKOTO
    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • サイトメガロウイルス虹彩炎に起因する続発性緑内障 15 例の臨床像
    村井 佑輔, 盛 崇太朗, SAKAMOTO MARI, 上田 香織, 芥子 結香子, KURIMOTO TAKUJI, KUSUHARA SENTARO, NAKANISHI YUKO, NAKAMURA MAKOTO
    第5回神戸大学眼科オープンカンファレンス, Nov. 2018, Japanese, 神戸, Domestic conference
    Oral presentation

  • 裂孔原性網膜剥離に対する27ゲージ硝子体手術後の歪視量に寄与する周術期因子の検討
    鉄本 章, IMAI HISANORI, 大塚 慶子, MATSUMIYA WATARU, MIKI AKIKO, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 糖尿病眼におけるslab en face OCT像と網膜内層厚
    勝山 敦子, KUSUHARA SENTARO, 西庄 龍東, MATSUMIYA WATARU, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 糖尿病黄斑浮腫治療成績とOCT en face slab像の関係
    KUSUHARA SENTARO, 勝山 敦子, MATSUMIYA WATARU, NAKAMURA MAKOTO
    第33回日糖尿病合併症学会・第24回日本糖尿病眼学会総会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 原因不明の硝子体出血眼に対する早期硝子体手術の効果
    林田 真由香, MIKI AKIKO, IMAI HISANORI, 大塚 慶子, 安積 淳, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • マイクロフックロトミーの術後短期成績
    金森 章泰, 金森 敬子, 椋野 洋和, 山中 弘光, 田邊 益美, 菅原いく子, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • ポリープ状脈絡膜血管症に対するaflibercept併用光線力学的療法の3年経過
    中井 駿一朗, MATSUMIYA WATARU, 本田 茂, 林田 真由香, MIKI AKIKO, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • ぶどう膜炎続発緑内障に対するテノン開創器を用いた線維柱帯切除術の短期成績
    KUSUHARA SENTARO, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • Vogt-小柳-原田病治療後の脈絡膜構造変化と再発前変動の検討
    西庄 龍東, MATSUMIYA WATARU, 勝山 敦子, 宇治 彰人, KUSUHARA SENTARO, NAKAMURA MAKOTO
    第72回日本臨床眼科学会, Oct. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • 下垂体茎断裂症候群に対するホルモン治療中に進行性の網膜変性症の合併を認めた１例
    金 景佑, MATSUMIYA WATARU, 勝山 敦子, KUSUHARA SENTARO, NAKAMURA MAKOTO
    日本臨床視覚電気生理学会, Sep. 2018, Japanese, 浜松, Domestic conference
    Oral presentation

  • 続発緑内障に対するテノン開創器を用いた線維柱帯切除術
    KUSUHARA SENTARO, NAKAMURA MAKOTO
    第22回眼創傷治癒研究会, Jul. 2018, Japanese, 奈良, Domestic conference
    Oral presentation

  • 神戸大学眼科における非感染性ぶどう膜炎に対するアダリムマブの使用経験
    KUSUHARA SENTARO, 勝山 敦子, MATSUMIYA WATARU, NAKAMURA MAKOTO
    第52回日本眼炎症学会, Jul. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • International Distinguished Papers Symposium Characteristics of vitreous cells in uveitis on optical coherence tomography
    Wataru Matsumiya, Sentaro Kusuhara, Atsuko Katsuyama, Akihito Uji, yoto, Makoto Nakamura
    フォーサム2018東京, Jul. 2018, English, 東京, Domestic conference
    Oral presentation

  • 3歳女児に生じたVogt-小柳-原田病疑い症例
    勝山 敦子, 楠原 仙太郎, 粟野 宏之, 永瀬 裕朗, MATSUMIYA WATARU, NAKAMURA MAKOTO
    フォーサム2018東京, Jul. 2018, Japanese, 東京, Domestic conference
    Oral presentation

  • Time Course of Changes in Aqueous Flare Intensity after 27-gauge pars plana Vitrectomy for Primary Rhegmatogenous Retinal Detachment
    Akira Tetsumoto, Hisanori Imai, Keiko Otsuka, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
    WOC, Jun. 2018, English, バルセロナ, International conference
    Oral presentation

  • Prediction of severe retinopathy of prematurity with WINROP algorithm in a Japanese poplulation of preterm infants
    Mayuka Hayashida, Akiko Miki, Kaori Ueda, Shunichiro Nakai, Yasukazu Nakamura, Hiroki Yasutake, Suiho Yanagisawa, Koji Nomura, Makoto Nakamura
    WOC, Jun. 2018, English, バルセロナ, International conference
    Oral presentation

  • 視路疾患の構造と機能を考える
    NAKAMURA MAKOTO
    第7回日本視野学会学術集会, May 2018, Japanese, 石川, Domestic conference
    Invited oral presentation

  • The disc-fovea-temporal raphe angle is associated with the severity of glaucoma with a hemi-field defect.
    Takuji Kurimoto, Sotaro Mori, Mari Sakamoto, Kaori Ueda, Yukako Inoue, Yuko Yamada, Makoto Nakamura
    23rd International visual field and imaging symposium, May 2018, English, 石川, Domestic conference
    Poster presentation

  • Agreement of a nasal step border by a microperimeter with a temporal raphe by optical coherence tomography in glaucoma patients
    Sotaro Mori, Mari Sakamoto, Takuji Kurimoto, Kaori Ueda, Yuko Nakanishi, Makoto Nakamura
    23rd International visual field and imaging symposium, May 2018, English, 石川, Domestic conference
    Poster presentation

  • 裂孔原性網膜剥離に対する27G硝子体手術後の前房フレア値に寄与する周術期因子の検討
    鉄本 章, IMAI HISANORI, 大塚 慶子, MATSUMIYA WATARU, MIKI AKIKO, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 未熟児網膜症既往眼における中心窩無血管領域と固視点安定性の関連
    林田 真由香, MIKI AKIKO, 中西 理恵, 島内 深希, 和田 友紀, INOUE YUKAKO, 山田 裕子, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 続発緑内障に対するテノン開創器を用いた線維柱帯切除術の短期成績
    KUSUHARA SENTARO, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 小児緑内障の治療
    NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • 光干渉断層計slab en face像を用いた糖尿病網膜内層構造変化の評価
    勝山 敦子, KUSUHARA SENTARO, MATSUMIYA WATARU, HONDA SHIGERU, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • ポリープ状脈絡膜血管症へのアフリベルセプト併用光線力学療法後の網膜色素上皮萎縮
    MATSUMIYA WATARU, HONDA SHIGERU, 林田 真由香, 中井 駿一朗, 勝山 敦子, 大塚 慶子, MIKI AKIKO, KUSUHARA SENTARO, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • ポリープ状脈絡膜血管症に対する光線力学的療法及びaflibercept併用療法と脈絡膜変化
    中井 駿一朗, MATSUMIYA WATARU, 本田 茂, MIKI AKIKO, 林田 真由香, 大塚 慶子, 近藤 陽子, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • アクアポリン9 遺伝子欠損マウスにおける視神経挫滅後の網膜神経節細胞死
    盛 崇太朗, KURIMOTO TAKUJI, MIKI AKIKO, KUSUHARA SENTARO, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • The impact of early vitrectomy for dense vitreous hemorrhage without a history of diabetic retinopathy
    Mayuka Hayashida, Akiko Miki, Hisanori Imai, Atsushi Azumi, Makoto Nakamura
    ARVO, Apr. 2018, English, ホノルル, International conference
    Oral presentation

  • The association of age-related maculopathy susceptibility 2 gene polymorphisms with the 12 months outcomes of combination therapy with intravitreal aflibercept and verteporfin photodynamic therapy for polypoidal choroidal vasculopathy.
    Shunichiro Nakai, Wataru Matsumiya, Shigeru Honda, Akiko Miki, Makoto Nakamura
    ARVO, Apr. 2018, English, ホノルル, International conference
    Oral presentation

  • Structural changes in the inner retina assessed by slab en face optical coherence tomography in diabetic eyes.
    Atsuko Katsuyama, Sentaro Kusuhara, Wataru Matsumiya, Shigeru Honda, Makoto Nakamura
    ARVO, Apr. 2018, English, ホノルル, International conference
    Oral presentation

  • OCTにおける緑内障パラメーター測定値の検者内再現性と検者間一致度
    金森 章泰, 若林 星太, NAKAMURA MAKOTO
    第122回日本眼科学会総会, Apr. 2018, Japanese, 大阪, Domestic conference
    Oral presentation

  • Evaluation of vitreoretinal cellular infiltration in uveitis on optical coherence tomography.
    Wataru Matsumiya, Sentaro Kusuhara, Atsuko Katsuyama, Akihito Uji, yoto, Makoto Nakamura
    ARVO, Apr. 2018, English, ホノルル, International conference
    Oral presentation

  • The impact of pancreatic duct stent in pancreatic fistula after pancreaticoduodenentomy: multicenter large observational study by Japan-Korean project, Symposium
    Kawai H, Jang JY, Ashida R, Unnno M, Nakamura Makoto, Fujii T, Kon M, Heo JS, Choi SH, Sho M, Ajiki Tetsuo
    7th A-PHPBA 29th JSHBPS, Jun. 2017, English, The University of Tokyo, Yokohama, Japan, International conference
    Public symposium

  • 視機能異常に対応した病院内設備とカラーユニバーサルデザイン
    Sugano Aki, 松浦正子, Miki Akiko, Ohta Mika, Nakamura Makoto, Takaoka Yutaka
    第87回福祉情報工学研究会, Dec. 2016, Japanese, 電子情報通信学会 福祉情報工学研究会, 東京, Domestic conference
    Oral presentation

  • 患者用パスの色覚異常への配慮の調査と作成ガイドラインの提案
    Takaoka Yutaka, Miki Akiko, Sugano Aki, 香川泰俊, Nakamura Makoto, 松浦正子
    第17回日本クリニカルパス学会, Nov. 2016, Japanese, 日本クリニカルパス学会, 金沢, Domestic conference
    Oral presentation

  • Incidence of kernicterus in Japanese preterm infants <30 wks gestation born in 2011
    Morioka Ichiro, Nakamura H, Okada H, Katayama Yoshio, Kunikata T, Kondo M, Nakamura Makoto, Hosono S, Yasuda S, Yokoyama N, Wada H, Yonetani M
    Pediatric Academic Societies (PAS) Annual Meeting 2016, Apr. 2016, English, Pediatric Academic Societies, Baltimore, USA, International conference
    Poster presentation

  • The natural course and response to treatments in the cases with peripapillary polypoidal choroidal vasculopathy,
    Miki Akiko, Honda Shigeru, 柳沢 翠芳, Matsumiya Wataru, 長井 隆之, Tsukahara Yasutomo, Nakamura Makoto
    APVS2013, Dec. 2013, English, Japanese Retina and Vitreous Society, 名古屋, International conference
    Oral presentation

  • 多局所視覚誘発電位の信号雑音比受信者操作特性曲線下面積の中期変動
    加藤 慶, 鎌田 誠子, 石川 久美子, Nakamura Makoto
    The 61th Meeting of Japanese Society for Clinical Electrophysiology of Vision, Oct. 2013, Japanese, Japanese Society for Clinical Electrophysiology of Vision, 大阪, Domestic conference
    Oral presentation

  • 関西緑内障道場 またまた帰ってきた悩みの相談室
    Nakamura Makoto, 大鳥 安正, 狩野 廉, 森 和彦, 植木 麻理
    The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference
    Public discourse

  • SD-OCTによる黄斑部解析の視交叉圧迫性視神経症の検出力
    Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, 松本 佳子, 坂本 麻里, 近藤 陽子, Yamada Yuko, Nakamura Makoto
    The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference
    Oral presentation

  • SD-OCTによる黄斑部解析での 菲薄化プロットパターンによる初期緑内障眼検出能
    中 真衣子, Kanamori Akiyasu, 明石 梓, 冨岡 真理, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto
    The 67th Annual Congress of Japan Clinical Ophthalmology, Oct. 2013, Japanese, Japanese Ophthalmological Society, 横浜, Domestic conference
    Oral presentation

  • 徹底検証！Glaucomatous optic axonopathy．イントロダクション
    Nakamura Makoto
    The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • 眼軸長と年齢が SD-OCTの網膜神経線維層と黄斑部内層網膜測定に及ぼす影響
    河賀 友紀, Kanamori Akiyasu, 島脇 由香, 冨岡 真里, 明石 梓, Nakamura Makoto
    The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference
    Oral presentation

  • この視野の症例は緑内障でしょうか？
    Nakamura Makoto
    The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference
    Public discourse

  • 3種のSD-OCTの黄斑部パラメータと視野の相関
    冨岡 真里, Kanamori Akiyasu, 河賀 友紀, 島脇 由香, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto
    The 24rd Meeting of Japan Glaucoma Society, Sep. 2013, Japanese, Japan Glaucoma Society, 東京, Domestic conference
    Oral presentation

  • シンポジウム「近視と緑内障」 高度近視のOCTと静的視野に及ぼす影響
    Nakamura Makoto
    The 3rd Annual Meeting of the Japan Perimetric Society, May 2013, Japanese, Japan Perimetric Society, 東京, Domestic conference
    [Invited]
    Nominated symposium

  • Syntaphilin is expressed in astrocytes in optic nerve and is down regulated in optic nerve after axonal injury
    Miki Akiko, Kanamori Akiyasu, Nakamura Makoto, 松本 佳子, 溝上 淳二, Negi Akira
    ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conference
    Oral presentation

  • Impact of plasma from patients with neuromyelitis optica spectrum disorders on the optic degeneration in rats
    松本 佳子, Kanamori Akiyasu, Nakamura Makoto, 中島 一郎, Negi Akira
    ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conference
    Oral presentation

  • Comparative assessment for the ability of macular parameters and circumpapillary retinal nerve fiber layer measured by three spectral-domain optical coherence tomograpahy insrtuments to diagnose glaucoma with high myopia
    明石 梓, Kanamori Akiyasu, Nakamura Makoto, Fujihara Masashi, Yamada Yuko, Negi Akira
    ARVO2012, May 2013, English, The Association For Research in Vision and Ophthalmology, Seattle, USA, International conference
    Oral presentation

  • 緑内障診療における視野の役割 光干渉断層計（OCT）との関係
    Nakamura Makoto
    The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • 視神経脊髄炎関連ラット視神経炎モデルの作製
    Kanamori Akiyasu, 松本 佳子, Nakamura Makoto, 中島 一郎, Negi Akira
    The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • マイクロビーズによる慢性高眼圧緑内障モデルの作成
    Kanamori Akiyasu, 松本 佳子, Nakamura Makoto, Negi Akira
    The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • 3種のSD-OCTの乳頭周囲網膜神経線維層と視野の相関
    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 117th Annual Meeting of Japanese Ophthalmological Society, Apr. 2013, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • 術後中後期合併症と対策I.トラベクレクトミー術後管理の実践講座
    Nakamura Makoto, 大鳥 安正, 狩野 廉, 森 和彦
    The 36th Annual Meeting of the Japanese Society of Ophthalmic Surgeons, Jan. 2013, Japanese, Japanese Society of Ophthalmic Surgeons, 福岡, Domestic conference
    Public discourse

  • トラベクレクトミー・術後早期から中期の合併症
    狩野 廉, 大鳥 安正, Nakamura Makoto, 植木 麻理, 森 和彦
    The 36th Annual Meeting of the Japanese Society of Ophthalmic Surgeons, Jan. 2013, Japanese, Japanese Society of Ophthalmic Surgeons, Domestic conference
    Public symposium

  • 小脳髄膜腫より腫瘍随伴性視神経症を発症した1例
    中野 沙弥, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Mizukawa Katsu, Negi Akira
    JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference
    Oral presentation

  • 視神経疾患、視覚路障害の病態解明に向けて
    Nakamura Makoto
    JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference
    [Invited]
    Nominated symposium

  • Spectral-domain OCTを用いたSSOHの網膜内構造の評価
    大西 健, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    JANOS2012, Nov. 2012, Japanese, Japanese Neuro-ophthalmology Society, 京都, Domestic conference
    Oral presentation

  • Anti-aquaporin-4 antibody-positive optic neuritis
    Nakamura Makoto
    American Academy of Ophthalmology・Asia-Pacific Academy of Ophthalmology Joint Meeting Chicago 2012, Nov. 2012, English, The Foundation of The American Academy of Ophthalmology, Chicago,USA, International conference
    Oral presentation

  • 緑内障の細分化により得られるもの RCTに基づく緑内障点眼薬の使い分け
    Nakamura Makoto
    The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference
    Public symposium

  • 多局所視覚誘発電位の受信者操作特性曲線解析に及ぼす高度近視の影響
    加藤 慶, 鎌田 誠子, 田渕 久美子, Nakamura Makoto, Negi Akira
    The 60th Meeting of Japanese Society for Clinical Electrophysiology of Vision, Oct. 2012, Japanese, Japanese Society for Clinical Electrophysiology of Vision, 名古屋, Domestic conference
    Oral presentation

  • CT時代の眼底のみかた千本ノック
    狩野 廉, 森 和彦, Nakamura Makoto, 大鳥 安正, 植木 麻理
    The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference
    Public discourse

  • 3種の光干渉断層計で測定した高眼圧症，Pre-perimetric glaucomaにおける視神経乳頭周囲網膜神経層厚の比較
    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 66th Annual Congress of Japan Clinical Ophthalmology, Oct. 2012, Japanese, Japanese Ophthalmological Society, 京都, Domestic conference
    Oral presentation

  • 自己眼圧測定器IcareONE®の精度および安全性の検討
    坂本 麻里, Kanamori Akiyasu, 明石 梓, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference
    Oral presentation

  • 視神経切断モデルにおけるsyntaphilinの変化
    Miki Akiko, Kanamori Akiyasu, Nakamura Makoto
    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference
    Oral presentation

  • ロジスティック回帰分析による線維柱帯切除術後の低眼圧黄斑症寄与因子の検討
    松本 佳子, Fujihara Masashi, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference
    Oral presentation

  • 3種のOCTによる高度近視群、非高度近視群における緑内障検出力の比較
    明石 梓, Kanamori Akiyasu, 坂本 麻里, Fujihara Masashi, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 23rd Meeting of Japan Glaucoma Society, Sep. 2012, Japanese, Japan Glaucoma Society, 金沢, Domestic conference
    Oral presentation

  • 長期経過において形態変化を認めた網膜つた状血管腫の一例
    Miki Akiko, Yamada Yuko, Kanamori Akiyasu, Nakamura Makoto, Negi Akira
    JASA2012, Jun. 2012, Japanese, Japanese Association of Strabismus and Amblyopia, 名古屋, Domestic conference
    Oral presentation

  • The association of altered aquaporin 9 expression with apoptosis of retinal ganglion cells.
    Miki Akiko, Kanamori Akiyasu, 中 真衣子, Negi Akira, Nakamura Makoto
    ARVO2012, May 2012, English, The Association For Research in Vision and Ophthalmology, Florida,USA, International conference
    Oral presentation

  • 緑内障における多局所視覚誘発電位と構造変化の一致性と相関
    Nakamura Makoto, 田渕 久美子, 近藤 誠子, Nagai Takayuki, Negi Akira
    The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • 外傷性視神経症における網膜神経線維層厚およびGanglion cell complexの経時的変化
    Kanamori Akiyasu, 田渕 久美子, 近藤 陽子, Yamada Yuko, Nakamura Makoto, Negi Akira
    The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Oral presentation

  • 「緑内障・視神経症」緑内障薬物治療のアップデート4. 具体的戦略2: 管理中の薬物変更、手術への移行
    Nakamura Makoto
    The 116th Annual Meeting of Japanese Ophthalmological Society, Apr. 2012, Japanese, Japanese Ophthalmological Society, 東京, Domestic conference
    Public symposium

  • Objective Functional assessment in Glaucoma
    Nakamura Makoto
    The 27th APAO/SOE Congress, Apr. 2012, English, The Korean Ophthalmological Society, Busan,Korea, International conference
    Oral presentation

  • トラベクレクトミー術後管理の実践講座
    大鳥 安正, 狩野 廉, 森 和彦, Nakamura Makoto
    第35回日本眼科手術学会, Jan. 2012, Japanese, 名古屋市立大学, 名古屋, Domestic conference
    Others

  • 二種のスペクトラル・ドメイン光干渉断層計のband atrophy検出能と一致性の検討
    Nakamura Makoto, 田渕 久美子, Kanamori Akiyasu, Yamada Yuko
    第49回日本神経眼科学会, Nov. 2011, Japanese, 兵庫医科大学, 神戸, Domestic conference
    Oral presentation

  • 日本視野研究会シンポジウム 視野を活かす、珠玉の症例集 視路疾患の局在診断と視野
    Nakamura Makoto
    第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference
    Oral presentation

  • 視覚経路症としての緑内障
    Nakamura Makoto
    第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference
    Others

  • 関西緑内障道場：緑内障症例「なやみの相談室4」
    大鳥 安正, 狩野 廉, Nakamura Makoto, 森 和彦
    第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference
    Others

  • 3種の光干渉断層計で測定した視神経乳頭線維層の緑内障検出能の比較検討
    Kanamori Akiyasu, 冨岡 真里, 河賀 友紀, 田渕 久美子, Yamada Yuko, Nakamura Makoto, Negi Akira
    第65回日本臨床眼科学会, Oct. 2011, Japanese, 日本大学, 東京, Domestic conference
    Oral presentation

  • ラット網膜神経節細胞死とアクアポリン9の発現変化の関連
    Miki Akiko, Kanamori Akiyasu, 溝上 淳二, 中 真衣子, Nakamura Makoto, Negi Akira
    第22回日本緑内障学会, Sep. 2011, Japanese, 日本緑内障学会, 秋田, Domestic conference
    Oral presentation

  • トラベクレクトミーはこうするんだ 術中の秘訣2
    Nakamura Makoto
    第22回日本緑内障学会, Sep. 2011, Japanese, 日本緑内障学会, 秋田, Domestic conference
    Others

  • 3種のスペクトラルドメイン光干渉断層計による視神経乳頭周囲網膜神経層厚の相関と一致性
    河賀 友紀, 冨岡 真里, 石川 久美子, Kanamori Akiyasu, Yamada Yuko, Nakamura Makoto, Negi Akira
    第22回日本緑内障学会, Sep. 2011, Japanese, 日本緑内障学会, 秋田, Domestic conference
    Oral presentation

  • Differences in filtering bleb structure associated with long-term intraocular pressure control between trabeculectomy with and without amniotic membrane transplantation.
    Nakamura Makoto, 中 真衣子, Yamada Yuko, Negi Akira
    世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference
    Oral presentation

  • A comparison of long-term outcomes between trabeculectomy with and without amniotic membrane transplantation for intractable glaucoma
    Yamada Yuko, Nakamura Makoto, Negi Akira
    世界緑内障会議, Jun. 2011, English, World Glaucoma Association, パリ, フランス, International conference
    Oral presentation

  • 緑内障性視神経症への挑戦 その基礎と臨床における三つの仮説の提唱
    Nakamura Makoto
    第115回日本眼科学会総会, May 2011, Japanese, 日本眼科学会, 東京, Domestic conference
    [Invited]
    Invited oral presentation

  • 小児緑内障手術を考える
    Nakamura Makoto
    第115回日本眼科学会総会, May 2011, Japanese, 日本眼科学会, 東京, Domestic conference
    Others

  • 緑内障点眼薬と神経保護
    Nakamura Makoto
    第64回日本臨床眼科学会, Nov. 2010, Japanese, 日本眼科学会, 神戸, Domestic conference
    Others

  • The role of aquaporin in glaucomatous optic neuropathy
    Nakamura Makoto
    APAO2010, Sep. 2010, English, International Council of Ophthalmology, 北京, 中国, International conference
    Oral presentation

  • 発達緑内障術後管理（視機能） 小児緑内障～治療と予後～
    Nakamura Makoto
    第66回日本弱視斜視学会総会・第35回日本小児眼科学会総会合同学会, Jul. 2010, Japanese, 日本斜視弱視学会・日本小児眼科学会, 東京, Domestic conference
    Others

  • 小児緑内障難治例に対する羊膜移植併用線維柱帯切除術の術後経過について
    Yamada Yuko, Nakamura Makoto, 石川 久美子, 溝上 淳二, Negi Akira
    第66回日本弱視斜視学会総会・第35回日本小児眼科学会総会合同学会, Jul. 2010, Japanese, 日本斜視弱視学会・日本小児眼科学会, 東京, Domestic conference
    Oral presentation

  • Elevated intraocular pressure reduces aquaporin-9 expression in rat optic nerve head and retina.
    Nakamura Makoto, Maiko Naka, Kanamori Akiyasu, Negi Akira
    WOC2010, Jun. 2010, English, International Council of Ophthalmology, ベルリン, ドイツ, International conference
    Oral presentation

  • 緑内障疾患感受性遺伝子によるオーダーメイド医療の可能性と問題点
    Nakamura Makoto
    第114回日本眼科学会総会, Apr. 2010, Japanese, 日本眼科学会, 名古屋, Domestic conference
    Others

  • よくわかる!緑内障診断ｽｷﾙｱｯﾌﾟｾﾐﾅｰ 初期緑内障を探しましょう 症例が教えてくれる眼底の見方
    Nakamura Makoto
    第114回日本眼科学会総会, Apr. 2010, Japanese, 日本眼科学会, 名古屋, Domestic conference
    Others

  • 反跳式眼圧計の圧平眼圧計に対する眼圧測定の一致性と角膜厚の及ぼす影響
    Nakamura Makoto, Maeda Hidetaka, Negi Akira
    第60回日本臨床眼科学会, Oct. 2006, Japanese, 日本臨床眼科学会, 京都, Domestic conference
    Oral presentation

  • 正常眼におけるOCT3とHRTによる網膜神経線維層厚測定値と視神経乳頭面積、眼軸長との相関
    Nakamura Makoto, Negi Akira
    第17回日本緑内障学会, Sep. 2006, Japanese, 日本緑内障学会, 神戸, Domestic conference
    Oral presentation

  • Dynamic Contour Tonometerにより測定されたOcular Pluse Amplitudeの検討
    Taguchi Koji, Nakamura Makoto, Negi Akira
    第17回日本緑内障学会, Sep. 2006, Japanese, 日本緑内障学会, 神戸, Domestic conference
    Oral presentation

  • 小児optic neurooathy こぼれ話
    Nakamura Makoto
    第31回日本小児眼科学会総会, Jun. 2006, Japanese, 日本小児眼科学会, 静岡, Domestic conference
    Oral presentation

  • 前房深度に対する機種間中心角膜厚の一致性
    Maeda Hidetaka, Nakamura Makoto, Negi Akira
    第110回日本眼科学会総会, Apr. 2006, Japanese, 日本眼科学会, 大阪, Domestic conference
    Oral presentation

  • 自然発症糖尿病ラットに初期網膜変化
    Nakamura Makoto, Negi Akira
    第110回日本眼科学会総会, Apr. 2006, Japanese, 日本眼科学会, 大阪, Domestic conference
    Oral presentation

  • 視覚の発生・再生と神経保護 網膜内インスリン/IGF-1シグナル情報伝達と神経保護作用
    Nakamura Makoto
    第110回日本眼科学会総会, Apr. 2006, Japanese, 日本眼科学会, 大阪, Domestic conference
    Oral presentation

  • Nitric oxide rescues retinal neurons from apoptosis through a cGMP / protein kinase G pathway that activates cAMP-responsive element binding protein
    Nakamura Makoto, Kanamori Akiyasu, Negi Akira
    ARVO2006, Apr. 2006, English, Fort Lauderdale, アメリ, International conference
    Oral presentation

  • Neural and Glial Change at Early Stage in Spontaneous Diabetes Torii rats
    Nakamura Makoto, Negi Akira
    ARVO2006, Apr. 2006, English, Fort Lauderdale, アメリ, International conference
    Oral presentation

  • Agreement of three types of instruments in measuring central corneal thickness and the association with the anterior depth
    Taguchi Koji, Maeda Hidetaka, Nakamura Makoto, Negi Akira
    ARVO2006, Apr. 2006, English, Fort Lauderdale, アメリ, International conference
    Oral presentation

  • 自然発症糖尿病ラット網膜のglial fibrillary acidic proteinの発現様式
    Nakamura Makoto, Negi Akira
    第12回日本糖尿病眼学会総会, Mar. 2006, Japanese, 群馬大学医学部眼科学教室, 東京, Domestic conference
    Oral presentation

  • 漏出濾過胞に対する羊膜併用濾過胞修復術の術後経過
    Taguchi Koji, Nakamura Makoto, Negi Akira
    第29回日本眼科手術学会, Jan. 2006, Japanese, 日本眼科手術学会, 東京, Domestic conference
    Oral presentation

  • 羊膜移植 疾患別治療戦略 緑内障
    Katakami Chikako, Nakamura Makoto
    第29回日本眼科手術学会, Jan. 2006, Japanese, 日本眼科手術学会, 東京, Domestic conference
    Oral presentation

  • Rebound tonometer（アイケア）とapplanation tonometerの一致性
    Nakamura Makoto, Taguchi Koji, Negi Akira
    第28回兵庫県緑内障研究会, Jan. 2006, Japanese, 兵庫県緑内障研究会, 神戸, Domestic conference
    Oral presentation

  • 急速に進行した両鼻側視野欠損の症例
    辰巳 康子, 平林 宏章, 楠原 あづさ, 中西 頼子, NAKAMURA, Makoto, NEGI, Akira
    日本神経眼科学会, Nov. 2005, Japanese, 大分, Domestic conference
    Oral presentation

  • OCT3とHRTによる圧迫性視神経症眼の視神経乳頭形状比較解析
    楠原 あづさ, 辰巳 康子, 中西 頼子, NAKAMURA, Makoto, NEGI, Akira
    日本神経眼科学会, Nov. 2005, Japanese, 大分, Domestic conference
    Oral presentation

  • ﾊｲﾃﾞﾙﾍﾞﾙｸﾞﾚﾃｨﾅﾄﾓｸﾞﾗﾌによる半視野欠損を有する緑内障眼の視神経頭形状解析
    楠原 あづさ, 辰巳 康子, 藤岡 美幸, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第５９回日本臨床眼科学会, Oct. 2005, Japanese, 札幌, Domestic conference
    Oral presentation

  • 正常眼に於ける連日および週一回ﾗﾀﾉﾌﾟﾛｽﾄ点眼による眼圧降下効果の比較
    Darhad Urtogtah, 藤岡 美幸, 辰巳 康子, 楠原 あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第５９回日本臨床眼科学会, Oct. 2005, Japanese, 札幌, Domestic conference
    Oral presentation

  • 強度近視性内斜視（AEHM)に対する上直筋縫縮術の4例
    平林 宏章, NAKAMURA, Makoto, NEGI, Akira
    第５９回日本臨床眼科学会, Oct. 2005, Japanese, 札幌, Domestic conference
    Oral presentation

  • 関西緑内障道場 悩みの相談室 続発緑内障編
    NAKAMURA, Makoto, 狩野 廉, 木内 良明, 杉本 哲也, 森 和彦, 大島 安正
    第５９回日本臨床眼科学会, Oct. 2005, Japanese, 札幌, Domestic conference
    Oral presentation

  • HRTによる視神経乳頭解析、CDｘ－VCCおよびOCTによる網膜神経線維層厚と網膜感度との相関
    KANAMORI,Akiyasu, 辰巳 康子, 藤岡 美幸, 楠原 あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第５９回日本臨床眼科学会, Oct. 2005, Japanese, 札幌, Domestic conference
    Oral presentation

  • ﾚｽｷｭﾗの謎を解く 神経保護経路を探る
    NAKAMURA, Makoto
    第１６回日本緑内障学会, Sep. 2005, Japanese, 神戸, Domestic conference
    Public symposium

  • 網膜神経線維層厚とRAPDの関係
    辰巳 康子, 藤岡 美幸, 楠原 あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第１６回日本緑内障学会, Sep. 2005, Japanese, 神戸, Domestic conference
    Oral presentation

  • 実験的ﾗｯﾄ緑内障網膜におけるinsulin/IGF-1受容体を介したAktの活性化
    NAKAMURA, Makoto
    第１６回日本緑内障学会, Sep. 2005, Japanese, 神戸, Domestic conference
    Public symposium

  • Bland and Altman plot 解析による各種中心角膜厚測定方の比較
    藤岡 美幸, 辰巳 康子, 楠原 あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第１６回日本緑内障学会, Sep. 2005, Japanese, 神戸, Domestic conference
    Oral presentation

  • ﾚｰｻﾞｰ虹彩切開術の角膜内皮細胞密度に及ぼす影響
    藤岡 美幸, 椋野 洋和, 辰巳 康子, 楠原 あづさ, MAEDA,Hidetaka, NAKAMURA, Makoto, KATAKAMI,Chikako, NEGI, Akira
    第１０９回日本眼科学会総会, Mar. 2005, Japanese, 日本眼科学会, 京都, Domestic conference
    Oral presentation

  • 糖尿病ﾗｯﾄの網膜神経細胞におけるﾗﾀﾉﾌﾟﾛｽﾄのｱﾎﾟﾄｰｼｽ抑制効果の検討
    中西 頼子, NAKAMURA, Makoto, 椋野 洋和, KANAMORI,Akiyasu, NEGI, Akira
    第１０９回日本眼科学会総会, Mar. 2005, Japanese, 日本眼科学会, 京都, Domestic conference
    Oral presentation

  • 眼瞼下垂再手術例の検討 ﾚｰｻﾞｰ虹彩切開術（L1）と水疱性角膜症（BK)
    椋野 洋和, 藤岡 美幸, NAKAMURA, Makoto, KATAKAMI,Chikako, NEGI, Akira
    第２４回神戸市立中央市民病院眼科ｵｰﾌﾟﾝｶﾝﾌｧﾗﾝｽ, Mar. 2005, Japanese, 神戸市立中央市民病院, 神戸, Domestic conference
    Oral presentation

  • どこまでわかってるの？神経保護と眼疾患 NOﾄﾞﾅｰの網膜神経細胞に対する抗ｱﾎﾟﾄｰｼｽ抑制効果の検討
    NAKAMURA, Makoto
    第１０９回日本眼科学会総会, Mar. 2005, Japanese, 日本眼科学会, 京都, Domestic conference
    Public symposium

  • 予防的ｱﾙｺﾞﾝﾚｰｻﾞｰ虹彩切開術後に生じた水疱性角膜症の検討
    椋野 洋和, 藤岡 美幸, NAKAMURA, Makoto, KATAKAMI,Chikako, NEGI, Akira
    第２９回角膜カンファランス・第２１回日本角膜移植学会, Feb. 2005, Japanese, 日本角膜移植学会, 徳島, Domestic conference
    Oral presentation

  • ｲﾝｽﾄﾗｸｼｮﾝｺｰｽ 羊膜移植－疾患別治療戦略－
    KATAKAMI,Chikako, NAKAMURA, Makoto, 島崎 潤, 外園 千恵, 大本 雅弘, 小林 顕, 五十嵐 羊羽
    第２８回日本眼科手術学会, Jan. 2005, Japanese, 日本眼科手術学会, 大阪, Domestic conference
    Public symposium

  • 関西緑内障道場 -なやみの相談室-
    木内 良明, 大鳥 安正, 森 和彦, 狩野 廉, NAKAMURA, Makoto, 杉山 哲也
    第５８回日本臨床眼科学会, Nov. 2004, Japanese, 日本臨床眼科学会, 東京, Domestic conference
    Public symposium

  • 難治な血管新生緑内障に対する羊膜移植併用経毛様体扁平部濾過手術
    藤岡 美幸, 辰巳 康子, 永井 あづさ, KANAMORI,Akiyasu, MAEDA,Hidetaka, NAKAMURA, Makoto, AZUMI, Atsushi, NEGI, Akira
    第１０６回兵庫県眼科医会学術集談会, Oct. 2004, Japanese, 兵庫県眼科医会, 神戸大学, Domestic conference
    Oral presentation

  • 相対的求心性瞳孔障害と光干渉断層計で測定した網膜神経線維層の関係
    中西 頼子, NAKAMURA, Makoto, 永井 あづさ, KANAMORI,Akiyasu, KUSUHARA, Sentaro, MAEDA,Hidetaka, NEGI, Akira, SEKIYA,Yoshibumi
    第４２回日本神経眼科学会総会, Oct. 2004, Japanese, 日本神経眼科学会, 名古屋, Domestic conference
    Oral presentation

  • 非緑内障性視神経症における乳頭陥凹
    NAKAMURA, Makoto
    第１５回日本緑内障学会, Sep. 2004, Japanese, 日本緑内障学会, 新潟, Domestic conference
    Oral presentation

  • R28細胞におけるニプラジロールのNO/cGMP/PKG経路による抗アポトーシス作用
    永井 あづさ, 椋野 洋和, KANAMORI,Akiyasu, NAKAMURA, Makoto, NEGI, Akira, Gail MSeigel
    第１５回日本緑内障学会, Sep. 2004, Japanese, 日本緑内障学会, 新潟, Domestic conference
    Oral presentation

  • GDx-VCC, 光干渉断層計、HRTの早期緑内障診断における比較検討
    KANAMORI,Akiyasu, 永井 あづさ, 辰巳 康子, 藤岡 美幸, MAEDA,Hidetaka, NAKAMURA, Makoto, NEGI, Akira
    第１５回日本緑内障学会, Sep. 2004, Japanese, 日本緑内障学会, 新潟, Domestic conference
    Oral presentation

  • 閉塞隅角緑内障と白内障手術
    NAKAMURA, Makoto
    第１９回日本眼内レンズ屈折矯正学会, Jun. 2004, Japanese, 日本眼内レンズ屈折矯正学会, 福岡, Domestic conference
    Oral presentation

  • 難治な血管新生緑内障に対する羊膜移植併用毛様体扁平部濾過手術
    藤岡 美幸, 辰巳 康子, 永井 あづさ, KANAMORI,Akiyasu, MAEDA,Hidetaka, NAKAMURA, Makoto, AZUMI, Atsushi, NEGI, Akira
    第１１０回京都眼科学会, Jun. 2004, Japanese, 京都眼科学会, 京都, Domestic conference
    Oral presentation

  • 小児白内障術後の近見、遠見視力発達
    中島 由美恵, 宮浦 望, 調 広子, KUSUHARA, Sentaro, ISHIBASHI, Kazuki, NAKAMURA, Makoto, NEGI, Akira, 山本 節
    第２９回日本小児眼科学会、第60回日本弱視斜視学会, Jun. 2004, Japanese, 日本小児眼科学会、日本弱視斜視学会, 沖縄, Domestic conference
    Oral presentation

  • ﾌﾟﾛｽﾀｸﾞﾗﾝﾃﾞｨﾝＦ２α関連薬のＲ２８細胞に対する抗ｱﾎﾟﾄｰｼｽ作用
    椋野 洋和, NAKAMURA, Makoto, 永井 あづさ, 中西 頼子, KANAMORI,Akiyasu, NEGI, Akira
    第１０８回日本眼科学会総会, Apr. 2004, Japanese, 日本眼科学会, 東京, Domestic conference
    Oral presentation

  • 糖尿病ﾗｯﾄ網膜におけるｲﾝｽﾘﾝ情報伝達傷害
    NAKAMURA, Makoto, Chad EN Reiter, David A, Antonetti, Tthomas W Gardner
    第１０８回日本眼科学会総会, Apr. 2004, Japanese, 日本眼科学会, 東京, Domestic conference
    Oral presentation

  • 慢性緑内障ﾗｯﾄ網膜神経細胞死に対する糖尿病の影響
    NAKAMURA, Makoto, KANAMORI,Akiyasu, NEGI, Akira
    第１０回日本糖尿病眼学会, Mar. 2004, Japanese, 日本糖尿病眼学会, 福岡, Domestic conference
    Oral presentation

  • 羊膜移植併用濾過手術の術後短期成績
    永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第２７回日本眼科手術学会総会, Jan. 2004, Japanese, 日本眼科手術学会, 東京, Domestic conference
    Oral presentation

  • 視神経疾患における乳頭周囲神経線維層厚と黄斑網膜厚の減少
    曽和 美幸, KUSUHARA, Sentaro, 永井 あづさ, 中西 頼子, KANAMORI,Akiyasu, YAMADA, Yuko, NAKAMURA, Makoto, NEGI, Akira, SEKIYA,Yoshibumi
    第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference
    Oral presentation

  • 視索症候群の網膜神経線維層厚
    辰巳 康子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira
    第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference
    Oral presentation

  • Band atrophyにおけるOCTによる網膜神経線維層厚の解析
    松井 敬子, KANAMORI,Akiyasu, 中西 頼子, 永井 あづさ, KUSUHARA, Sentaro, YAMADA, Yuko, NAKAMURA, Makoto, SEKIYA,Yoshibumi, NEGI, Akira
    第４１回日本神経眼科学会, Dec. 2003, Japanese, 日本神経眼科学会, 京都, Domestic conference
    Oral presentation

  • 線維柱帯切除術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較～
    永井 あづさ, KANAMORI,Akiyasu, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第５７回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference
    Oral presentation

  • 線維柱帯切除術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較
    永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第６９回日本中部眼科学会、第１００回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、中国四国眼科学会, 岡山, Domestic conference
    Oral presentation

  • 線維柱帯切開術の術後中期成績～輪部基底結膜切開と円蓋部基底結膜切開の比較～
    永井 あづさ, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第１０３回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference
    Oral presentation

  • 正常眼圧緑内障 診断の要点
    NAKAMURA, Makoto
    第６９回日本中部眼科学会、第１００回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、, 岡山, Domestic conference
    Public symposium

  • 上下半視野による光干渉断層計を用いた網膜神経線維層厚の解析
    KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第６９回日本中部眼科学会、第１００回中国四国眼科学会, Oct. 2003, Japanese, 日本中部眼科学会、, 岡山, Domestic conference
    Oral presentation

  • 上下半視野におけるOCTによる網膜神経線維層厚の解析
    KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第５７回日本臨床眼科学会, Oct. 2003, Japanese, 日本臨床眼科学会, 名古屋, Domestic conference
    Oral presentation

  • 上下半視野におけるOCTによる網膜神経線維層厚の解析
    KANAMORI,Akiyasu, 永井 あづさ, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第１０３回兵庫県眼科医会学術集談会, Oct. 2003, Japanese, 日本眼科医会, 神戸大学, Domestic conference
    Oral presentation

  • スリット検査をマスターする ２．緑内障
    NAKAMURA, Makoto
    第３９回日本眼光学学会, Sep. 2003, Japanese, 日本眼光学学会, 大阪, Domestic conference
    Oral presentation

  • 線維柱帯切除術合併症対策
    NAKAMURA, Makoto
    北神戸眼科カンファレンス, Jul. 2003, Japanese, 北神戸眼科, 神戸, Domestic conference
    Oral presentation

  • 眼圧変動に伴い視神経乳頭陥凹が著明な変化を繰り返した成人症例
    角谷 庸子, KANAMORI,Akiyasu, 瀬谷 隆, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference
    Oral presentation

  • ラット緑内障モデル網膜内アポトーシスへの糖尿病の影響
    NAKAMURA, Makoto, KANAMORI,Akiyasu, NEGI, Akira
    第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference
    Oral presentation

  • ラット慢性緑内障モデル網膜におけるAktの発現及びリン酸化
    KANAMORI,Akiyasu, 椋野 洋和, YAMADA, Yuko, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference
    Oral presentation

  • ウノブロストンイソプロピルのR２８細胞に対する保護作用
    椋野 洋和, NAKAMURA, Makoto, KANAMORI,Akiyasu, NEGI, Akira
    第１４回日本緑内障学会, Jul. 2003, Japanese, 日本緑内障学会, 東京, Domestic conference
    Oral presentation

  • 糖尿病網膜症におけるニューロン、グリア、血管内皮の異常相互作用
    NAKAMURA, Makoto
    第１０９回京都眼科学会, Jun. 2003, Japanese, 京都眼科学会, 京都, Domestic conference
    Oral presentation

  • 先天緑内障の治療戦略 -管理と予後-
    NAKAMURA, Makoto
    第５９回日本弱視斜視学会総会、第２８回日本小児眼科学会総会合同学会, Jun. 2003, Japanese, 日本弱視斜視学会、日本小児眼科学会, 神戸, Domestic conference
    Public symposium

  • 神経線維腫症に合併した先天緑内障の１例
    福村 美帆, YAMADA, Yuko, KANAMORI,Akiyasu, 瀬谷 隆, MATSUBARA,Satoshi, NAKAMURA, Makoto, NEGI, Akira
    第５９回日本弱視斜視学会総会、第２８回日本小児眼科学会総会合同学会, Jun. 2003, Japanese, 日本弱視斜視学会、日本小児眼科学会, 神戸, Domestic conference
    Oral presentation

  • 小児先天緑内障の治療戦略
    NAKAMURA, Makoto
    第５９回日本弱視斜視学会総会、第２８回日本小児眼科学会総会合同学会, Jun. 2003, Japanese, 日本弱視斜視学会、日本小児眼科学会, 神戸, Domestic conference
    Public symposium

  • トラベルレクトミーの術後合併症対策のトライアル
    NAKAMURA, Makoto
    第１０７回日本眼科学会総会, Apr. 2003, Japanese, 日本眼科学会, 福岡, Domestic conference
    Public symposium

  • トラベルレクトミーの危機管理
    NAKAMURA, Makoto
    第１０７回日本眼科学会総会, Apr. 2003, Japanese, 日本眼科学会, 福岡, Domestic conference
    Public symposium

  • 眼圧の変動に伴い視神経乳頭陥凹が著明に縮小/拡大した成人症例
    KANAMORI AKIYASU, NAKAMURA MAKOTO, NEGI AKIRA
    第２６回日本眼科手術学会, Jan. 2003, Japanese, 日本眼科手術学会, 京都, Domestic conference
    Oral presentation

■ Affiliated Academic Society
  • 日本小児眼科学会

  • 日本弱視斜視学会

  • 日本臨床視覚電気生理学会 理事

  • 日本視野画像学会 理事

  • 日本神経眼科学会 理事

  • 日本緑内障学会 理事

  • 日本眼科学会 評議員

■ Research Themes
  • Proposal of a novel pathomechanism of glaucomatous optic neuropathy as dysregulated lactate shuttle and signal transduction and exploration of treatment
    中村 誠, 坂本 麻里, 楠原 仙太郎, 目黒 明, 盛 崇太朗, 真田 昌爾
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Kobe University, 01 Apr. 2024 - 31 Mar. 2027

  • 乳酸シャトル概念に基づく網膜・視神経変性疾患の病態解明と治療法の探索
    中村 誠
    学術研究助成基金助成金, 科学研究費助成事業, 基盤研究C, 神戸大学, Apr. 2022 - Mar. 2024, Principal investigator
    マウス高眼圧モデルとして、マイクロビーズと粘弾性物質の前房内注入によって4週にわたり眼圧上昇できることを確認した。このマウスで、網膜進展標本を作製し、TUJ1免疫染色くを行ったところ、網膜神経節細胞が経時的に有意に脱落することをで確認した。Weestern blotting, 免疫沈降、ならびに免疫染色により、高眼圧モデルマウスでは、網膜内アクアポリン9(AQP9)、monocarboxylate transporter (MCT)1,2,4の発現が有意に低下していた。 視神経挫滅モデル１週で、24時間案順応後に暗所視閾値電位(STR)を測定したところ、STRが有意に低下した一方で、強い刺激によるa波、b波には変化はなく、このSTRの変化は視細胞や双極細胞の変化に続発するものではなく、網膜神経節細胞の機能低下であることが示された。また網膜伸展標本とTUJ1免疫染色で、高眼圧モデル同様網膜神経節細胞死が有意に増加した。また同じく、AQP9, MCT1,2,4の発現低下がみられた。 視神経挫滅マウスに高濃度乳酸を吸入麻酔下で3時間腹腔内投与することにより、網膜神経節細胞死、STR低下、AQP9, MCT1,2,4の発現低下は有意に改善した。 網膜の解糖系、電子伝達系の基質を質量分析装置でメタボローム解析を行ったところ、網膜内ではglucoseよりもL-lactateの濃度の方が有意に高かった。 網膜では定常状態下でも乳酸がグルコースよりも豊富に存在し、高眼圧や視神経挫滅で乳酸輸送体の発現が低下し、網膜神経節細胞の機能不全と細胞死が生じるが、外因性の乳酸投与が神経保護効果を発揮する可能性が示された。

  • 中村 誠
    学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021, Principal investigator
    Competitive research funding

  • 栗本 拓治
    学術研究助成基金助成金／基盤研究(C), Apr. 2017 - Mar. 2020
    Competitive research funding

  • 中村 誠
    学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017, Principal investigator
    Competitive research funding

  • （AMED）次世代眼科医療を目指す、ICT/人工知能を活用した画像等データベースの基盤構築
    中村 誠
    国立大学法人筑波大学, 臨床研究等ＩＣＴ基盤構築・人工知能実装研究事業, 2017, Principal investigator
    Competitive research funding

  • 中村 誠
    学術研究助成基金助成金／基盤研究(C), 2011, Principal investigator
    Competitive research funding

  • 根木 昭
    科学研究費補助金／基盤研究(B), 2010
    Competitive research funding

  • 中村 誠
    科学研究費補助金／基盤研究(C), 2008, Principal investigator
    Competitive research funding

  • 根木 昭
    科学研究費補助金／基盤研究(B), 2007
    Competitive research funding

  • 根木 昭
    科学研究費補助金／基盤研究(B), 2005
    Competitive research funding

  • 中村 誠
    科学研究費補助金／基盤研究(C), 2005, Principal investigator
    Competitive research funding

  • 糖尿病網膜症における高血糖と網膜神経細胞死の因果関係の解析
    中村 誠
    日本学術振興会, 科学研究費助成事業, 若手研究(B), 神戸大学, 2002 - 2004
    上強膜静脈焼灼により、ラット片眼慢性高眼圧モデルを作製した。対眼には結膜切開のみのsham-operationを行った。眼圧をウレタン麻酔下で測定後、網膜を摘出し、クライオ切片ないし伸展標本作成後、リン酸化Aktによる免疫染色、terminal dUTP nick end labeling (TUNEL)染色、全およびリン酸化Akt抗体、リン酸化インスリン/IGF-1受容体抗体、およびインスリンβ受容体抗体を用いてWestern blottingを行った。組織摘出時期は、上強膜静脈焼灼後3日、2週、1ヶ月、3ヶ月の時点である。 結果、眼圧は、3日後にピークとなった後、経時的に減少していたが、3ヶ月まで対眼に比べ有意に上昇していた。眼圧上昇に対応して、TUNEL染色陽性細胞数は上昇し、眼圧依存性のアポトーシスによるRGCの減少が見られた。クライオ切片ならびに伸展標本による免疫染色では、RGCが特異的にリン酸化Aktを発現しており、リン酸化Akt陽性RGCは3日後がピークで、一ヶ月後までみられた。Western blottingにより、リン酸化Aktの発現上昇に呼応して、インスリン/IGF-1受容体のリン酸化が上昇していた。慢性高眼圧ストレスによりRGCがアポトーシスを生じるが、それを代償するインスリン/IGF-1からAkt経路が、RGCにおいて賦活化されている可能性が示唆された。 また、ストレプトゾトシン誘発糖尿病ラットに同様の高眼圧ストレスを負荷した場合、各々単独のストレス負荷よりRGCアポトーシス数が増加することから、糖尿病は緑内障性視神経障害の危険因子である総説を作製した。 さらに、ウノプロストンがこれら網膜神経細胞のアポトーシスを抑制するかどうかを検討するため、活性化代謝物M1とM2を網膜前駆細胞R28細胞に投与し、血清除去により誘導されるアポトーシスに対する保護効果を検討した。その結果、M1のみがPI3K, PKG経路を活性化することで、アポトーシスを抑制することが判明した。

  • Analysis of intraretinal neuro-glial interaction in glaucoma
    NEGI Akira, NAKAMURA Makoto
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 2002 - 2003
    1.In an attempt to elucidate the causal effect of diabetes on development of glaucomatous optic neuropathy, male Sprague-Dawley rats were made diabetic by streptozotocin injection, in which unilateral eyes were treated with episcleral vein cauterization to produce chronically elevated intraocular pressure (IOP). Terminal dUTP nick end-labeling (TUNEL) staining was performed on the flat-mount retina dissected at several time points of sacrifice. The number of TUNEL positive cells in the inner retina was significantly higher in diabetic retina with episcleral vein 'cauterization than in control retina with same operation. Thus, diabetes has an additive effect on neuronal apoptosis induced by glaucoma in rats. 2.In order to identify whether the pro-survival Akt pathway is activated in retina with chronically elevated IOP, immunohistochmeistry in the crysosection and in the whole mount retina as well as immunoblotting with retinal homogenates were conducted for rat retina with episcleral vein cauterization. Akt phorphorylated at Ser 437 was specifically expressed in the retinal ganglion cells in the retina with cauterization, but not in the contralateral retina. Phosphorylated relative to total Akt was significantly increased in retina with cauterization. Thus, Akt activation may counteract against increased IOP stress in retina. 3.Finally, to test whether glial reactivity was altered in glaucomatous retina, immunostaining and immunoblotting for glial fibrially acidic protein (GFAP) was conducted in the same experimental glaucoma model as in 2. Astrocytes lost and Muller cells gained GFAP imunoreactivity as early as at 3 days after episcleral vein cauterization, which was partially reversed overtime but last up to 6 months. GFAP molecular mobility and acidity were also changed by the cauterization. Similar observations were also occurred in the contrallateral retina at 1 month and thereafter. Thus, epicsleral vein cauterization altered glial reactivity not only in the ipsilateral but also in the contralateral eyes in rats.

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