Research activity information

• Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosterone.

  Katsuya Sato, Michiyo Koyanagi-Aoi, Keiichiro Uehara, Yosuke Yamashita, Masakazu Shinohara, Suji Lee, Anika Reinhardt, Knut Woltjen, Koji Chiba, Hideaki Miyake, Masato Fujisawa, Takashi Aoi

  Late-onset hypogonadism (LOH) syndrome is characterized by age-related testosterone deficiency and negatively affects the quality of life of older men. A promising therapeutic approach for LOH syndrome is transplantation of testosterone-producing Leydig-like cells (LLCs) derived from human induced pluripotent stem cells (hiPSCs). However, previous studies have encountered obstacles, such as limited cell longevity, insufficient testosterone production, and inefficiency of differentiation. To address these issues, we developed a novel protocol that includes forced NR5A1 expression, a cytokine cocktail promoting mesoderm differentiation, and a transitional shift from 3D to 2D cultures. The resultant cells survived on culture dishes for over 16 weeks, produced 22-fold more testosterone than the conventional method, and constituted a homogeneous population of LLCs with a differentiation efficiency exceeding 99% without purification. Furthermore, these LLCs were successfully engrafted subcutaneously into mice, resulting in increased serum testosterone levels. Our study will facilitate innovative therapeutic strategies for LOH syndrome.

  Jan. 2025, Stem cell reports, 102392 - 102392, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• LOH症候群に対する新しい再生医療の開発

  佐藤 克哉, 山下 遥介, 河村 駿, 賀來 泰大, 千葉 公嗣, 小柳 三千代, 青井 貴之, 藤澤 正人

  (一社)日本性機能学会, Aug. 2023, 日本性機能学会雑誌, 38(2) (2), 131 - 131, Japanese


• Improvement in semen parameters by switching steroids in a male congenital adrenal hyperplasia patient with severe oligozoospermia.

  Atsushi Onishi, Keisuke Okada, Katsuya Sato, Yasuhiro Kaku, Koji Chiba, Masato Fujisawa

  Congenital adrenal hyperplasia (CAH) causes hypogonadotropic hypogonadism due to the excessive production of adrenal androgens, which results in hypospermatogenesis in some male patients. We herein present a CAH case with hypogonadotropic hypogonadism and male infertility. A 26-year-old male receiving steroid therapy for 21 hydroxylase deficiency was diagnosed with low gonadotropin levels, an elevated ACTH level, and severe oligozoospermia. The switching from hydrocortisone to dexamethasone resulted in the normalization of gonadotropin levels and semen findings. The couple underwent ICSI-ET, resulting in a live birth. In cases of CAH with hypospermatogenesis, the continuous suppression of ACTH by dexamethasone may restore spermatogenesis.

  Mar. 2023, Urology case reports, 47, 102368 - 102368, English, International magazine


• 悪性パラガングリオーマ多発骨転移に対し,集学的治療を行った1例

  楠瀬 正史, 鈴木 光太郎, 寺川 智章, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克己, 日向 信之, 石村 武志, 中野 雄造, 藤澤 正人

  泌尿器科紀要刊行会, Dec. 2022, 泌尿器科紀要, 68(12) (12), 397 - 397, Japanese


• 後腹膜腫瘍摘除術を施行し診断したSolitary fibrous tumorの1例

  島田 良希, 岡村 泰義, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克巳, 日向 信之, 石村 武志, 中野 雄造, 藤澤 正人

  泌尿器科紀要刊行会, Dec. 2022, 泌尿器科紀要, 68(12) (12), 399 - 400, Japanese


• 腎移植後の免疫抑制療法においてエベロリムスがミコフェノール酸の薬物動態に与える影響

  遠藤 貴人, 石村 武志, 藤本 卓也, 西岡 遵, 横山 直己, 小川 悟史, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克巳, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Dec. 2021, 日本泌尿器科学会総会, 109回, PP47 - 02, Japanese


• 腎移植周術期のClostridium difficile infectionに関する検討

  西岡 遵, 藤本 卓也, 遠藤 貴人, 横山 直己, 小川 悟史, 石村 武志, 千葉 公嗣, 古川 順也, 重村 克巳, 原田 健一, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Dec. 2021, 日本泌尿器科学会総会, 109回, PP47 - 08, Japanese


• 神戸大学医学部附属病院における尿中分離菌・薬剤感受性成績の年次推移

  中野 雄造, 重村 克巳, 千葉 公嗣, 古川 順也, 原田 健一, 石村 武志, 日向 信之, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Dec. 2021, 日本泌尿器科学会総会, 109回, PP50 - 07, Japanese


• 日本性機能学会員を対象とした男性の性被害者に対する実態調査

  辻村 晃, 福原 慎一郎, 千葉 公嗣, 菊地 栄次, 吉澤 剛, 巴 ひかる, 木村 和哲, 佐藤 嘉一, 永井 敦, 永尾 光一

  (一社)日本性機能学会, Dec. 2021, 日本性機能学会雑誌, 36(3) (3), 178 - 178, Japanese


• 当科における小児造血細胞移植患者の精子保存(The sperm preservation in pediatric patients who underwent hematopoietic stem cell transplantation)

  藤川 朋子, 植村 優, 中谷 尚子, 二野 菜々子, 山本 暢之, 西村 範行, 岡田 桂輔, 千葉 公嗣, 塩谷 雅英, 飯島 一誠

  (一社)日本血液学会, Sep. 2021, 日本血液学会学術集会, 83回, PS - 2, English


• The sperm preservation in pediatric patients who underwent hematopoietic stem cell transplantation(和訳中)

  藤川 朋子, 植村 優, 中谷 尚子, 二野 菜々子, 山本 暢之, 西村 範行, 岡田 桂輔, 千葉 公嗣, 塩谷 雅英, 飯島 一誠

  (一社)日本血液学会, Sep. 2021, 日本血液学会学術集会, 83回, PS - 2, English


• Pembrolizumab投与後7ヵ月目にirAEとして一型糖尿病、消化管壊死を来たした転移性膀胱癌の1例

  松山 直幹, 大西 篤史, 原 琢人, 千葉 公嗣, 松下 経, 古川 順也, 原田 健一, 石村 武志, 重村 克巳, 日向 信之, 中野 雄造, 白川 利朗, 藤澤 正人

  泌尿器科紀要刊行会, Jun. 2021, 泌尿器科紀要, 67(6) (6), 259 - 259, Japanese


• 神戸大学における結節性硬化症に対するエベロリムスの治療成績

  千葉 公嗣, 賀来 泰大, 原田 健一, 重村 克巳, 日向 信之, 石村 武志, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Dec. 2020, 日本泌尿器科学会総会, 108回, 1790 - 1790, Japanese


• 神戸大学における結節性硬化症に対するエベロリムスの治療成績

  千葉 公嗣, 賀来 泰大, 原田 健一, 重村 克巳, 日向 信之, 石村 武志, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Dec. 2020, 日本泌尿器科学会総会, 108回, 1790 - 1790, Japanese


• 馬蹄鉄腎に発生した腎細胞癌に対する後腹膜鏡下腎摘除術

  古川 順也, 寺川 智章, 千葉 公嗣, 重村 克巳, 原田 健一, 日向 信之, 石村 武志, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2020, 日本泌尿器内視鏡学会総会, 34回, V - 3, Japanese


• 褐色細胞腫に対する腹腔鏡下副腎摘除術の臨床的検討

  高橋 昂佑, 千葉 公嗣, 古川 順也, 原田 健一, 松下 経, 石村 武志, 重村 克巳, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2020, 日本泌尿器内視鏡学会総会, 34回, P - 6, Japanese


• Sperm retrieval from a male with the rare 47, XXYqs variant of Klinefelter syndrome for intracytoplasmic sperm injection: A case report.

  Noritoshi Enatsu, Yihsien Enatsu, Keisuke Okada, Koji Chiba, Yukiko Matsumoto, Shoji Kokeguchi, Masahide Shiotani

  A 27-year-old man with nonobstructive azoospermia was diagnosed with Klinefelter syndrome (KS) with a satellite Y chromosome (47, XXYqs) by karyotyping. Genetic analysis revealed azoospermia factor c (AZFc) microdeletion of gr/gr deletion in the Y chromosome. Microdissection testicular sperm extraction (micro-TESE) was performed in bilateral testes. Very few seminiferous tubules were bilaterally observed, and a minute number of spermatozoa obtained from the left testis were cryopreserved. Histologic examination of the left testicular tissue revealed severe tubular atrophy with only Sertoli cells accompanied by Leydig cell hyperplasia. Oocyte harvest was conducted in his wife in two different cycles after ovarian stimulation, and intracytoplasmic sperm injection was performed for 24 oocytes (8 and 16 oocytes respectively) using thawed spermatozoa. Fertilisation was confirmed in total of 19 oocytes (79.2%), with 15 cleaved embryos (62.5%). Two cleavage-stage embryos were cryopreserved at day 2, but no blastocysts developed. Frozen-thawed embryo transfer was performed using two cleavage-stage (day 2) embryos; however, the wife did not conceive. In conclusion, spermatozoa were successfully obtained by micro-TESE from a patient with 47, XXYqs. Despite failure of conception, the fertilisation and cleavage rates were comparable or better than those reported in patients with "typical" KS.

  Feb. 2020, Andrologia, 52(1) (1), e13489, English, International magazine

  Scientific journal


• Effect of mirabegron on tight junction molecules in primary cultured rat Sertoli cells.

  Mikito Tanaka, Koji Chiba, Keisuke Okada, Masato Fujisawa

  Mirabegron is a selective beta3-adrenoceptor (β3 -AR) agonist, which is commonly used for the treatment of overactive bladder. This medicine is associated with atrophy of reproductive organs in rats. However, no study has examined the detailed action and mechanism of its toxicity in reproductive cells. In this study, we examined the effect of mirabegron on primary cultured rat Sertoli cells. Firstly, RT-PCR and immunocytochemistry revealed that β3 -AR was present in rat Sertoli cells. Then, primary cultured rat Sertoli cells were treated with mirabegron. Quantitative real-time PCR revealed that mirabegron treatment induced a significant increase in claudin-11 mRNA, which is crucial for spermatogenesis. Western blot analysis also showed that mirabegron treatment significantly activated p44/42 mitogen-activated protein kinase (MAPK). After additional treatment with U0126, a specific noncompetitive inhibitor of mitogen-activated protein kinase kinase (MAPKK), the upregulation of claudin-11 mRNA induced by mirabegron was reduced. At the same time, immunocytochemistry showed mirabegron treatment disturbed claudin-11 localisation to tight junction, which was recovered when treated with mirabegron in the presence of U0126. These results suggest that mirabegron treatment is associated with assembly of the blood-testis barrier through p44/42 MAPK pathway. These findings could explain one of the underlying mechanisms of reproductive toxicity induced by mirabegron.

  Jun. 2019, Andrologia, 51(5) (5), e13241, English, International magazine

  [Refereed]

  Scientific journal


• Application of hyaluronic acid/carboxymethyl cellulose membrane for early continence after nerve-sparing robot-assisted radical prostatectomy.

  Nobuyuki Hinata, Yukari Bando, Koji Chiba, Junya Furukawa, Kenichi Harada, Takeshi Ishimura, Yuzo Nakano, Masato Fujisawa

  BACKGROUND: To assess whether application of a hyaluronic acid-carboxymethyl cellulose membrane (HA/CMC) to the prostate bed and neurovascular plate facilitated early return of continence after nerve-sparing robot-assisted radical prostatectomy (RARP). METHODS: The subjects were 183 consecutive patients with organ-confined prostate cancer who underwent unilateral or bilateral nerve-sparing RARP. After vesicourethral anastomosis, HA/CMC was placed to cover Denonvilliers' fascia (behind the anastomotic suture) and the preserved neurovascular plate. The time until complete continence after RARP and perioperative complications were compared between patients with or without HA/CMC. RESULTS: HA/CMC was applied in 13/46 patients (28.3%) receiving bilateral nerve-sparing surgery and 40/137 patients (29.2%) receiving unilateral nerve-sparing surgery. After bilateral nerve-sparing RARP, the median time until continence was significantly shorter in patients with HA/CMC than in those without HA/CMC (3.2 vs. 9.3 months, respectively, p < 0.01). After unilateral nerve-sparing RARP, the median time until continence was also significantly shorter in patients with HA/CMC than in those without HA/CMC (3.2 vs. 12.0 months, respectively, p < 0.01). Multivariate Cox proportional hazards regression analysis showed that an age < 70 years (hazard ratio [HR]: 1.74, 95% confidence interval [CI]: 1.12-2.80), institutional caseload > 200, (HR: 1.64, 95%CI: 1.10-2.47), and use of HA/CMC (HR: 1.84, 95%CI: 1.22-2.76) were independent predictors of early postoperative continence. Complication rates, including urinary leakage, did not differ significantly between patients with or without HA/CMC. CONCLUSION: Application of HA/CMC to the prostate bed and neurovascular plate resulted in significantly faster postoperative return of continence after both unilateral and bilateral nerve-sparing RARP.

  Apr. 2019, BMC urology, 19(1) (1), 25 - 25, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Improved Lower Urinary Tract Symptoms Associated With Testosterone Replacement Therapy in Japanese Men With Late-Onset Hypogonadism.

  Keisuke Okada, Hideaki Miyake, Takaki Ishida, Kenta Sumii, Noritoshi Enatsu, Koji Chiba, Kei Matsushita, Masato Fujisawa

  This study aimed to investigate the effects of testosterone replacement therapy (TRT) on lower urinary tract symptoms (LUTS) in men with late-onset hypogonadism (LOH) and to identify parameters predicting the efficacy of TRT in improving LUTS. This study included 60 consecutive Japanese men who were diagnosed with LOH and subsequently received TRT between January 2009 and December 2014. In this series, 250 mg of testosterone was injected intramuscularly every 3 or 4 weeks in all patients. The following parameters were retrospectively reviewed: body mass index (BMI), Aging Male Symptom (AMS) score, International Prostate Symptom Score (IPSS), International Index of Erectile Function-5 (IIEF-5) score, residual urine volume, prostate volume, serum levels of the prostate-specific antigen (PSA), and total- and free-testosterone levels before and 6 months after TRT. No significant differences were observed in BMI, residual urine volume, or prostate volume between surveys before and after TRT. The AMS score, IPSS, and IIEF-5 score were significantly improved and significant increases were noted in the serum levels of PSA and total- and free-testosterone levels after TRT. An analysis of IPSS subscores documented the significant improvement in storage symptom scores, but not in voiding symptom scores after TRT. Multivariate analyses of parameters assessed in this study identified the pretreatment AMS score, posttreatment IIEF-5 score, and prostate volume as independent predictors of improvements in IPSS following TRT. This study revealed that TRT appeared to have considerable therapeutic effects on LUTS, particularly on storage symptoms, in men with LOH.

  Sep. 2018, American journal of men's health, 12(5) (5), 1403 - 1408, English, International magazine

  [Refereed]

  Scientific journal


• Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan.

  Yasushi Yumura, Akira Tsujimura, Takashi Imamoto, Yukihiro Umemoto, Hideyuki Kobayashi, Koji Shiraishi, Takeshi Shin, Hisanori Taniguchi, Koji Chiba, Yasushi Miyagawa, Teruaki Iwamoto

  Purpose: To investigate the incidence, etiology, treatment indications, and outcomes regarding infertile male patients in Japan. Methods: Between April, 2014 and March, 2015, the authors contacted 47 clinical specialists in male infertility who had been certified by the Japan Society for Reproductive Medicine. The participating clinicians were sent a questionnaire regarding information on their infertile patients, according to etiology and the number and success rates of male infertility operations that had been performed in their practice. Results: Thirty-nine specialists returned the questionnaire and provided information regarding 7268 patients. The etiology of infertility included testicular factors, sexual disorders, and seminal tract obstruction. During the study year, the clinicians performed varicocelectomies, testicular sperm extractions (TESEs), and re-anastomoses of the seminal tract. The rate of successful varicocelectomies was >70%. The sperm retrieval rates with conventional TESE and microdissection TESE were 98.3% and 34.0%, respectively, while the patency rates with vasovasostomy and epididymovasostomy were 81.8% and 61.0%, respectively. Conclusion: Surgical outcomes for infertile male patients are favorable and can be of great clinical benefit for infertile couples. To achieve this, urologists should work in collaboration with gynecological specialists in order to optimize the treatment of both partners.

  Jan. 2018, Reproductive medicine and biology, 17(1) (1), 44 - 51, English, Domestic magazine

  Scientific journal


• Dutasteride-mediated morphological changes in the genitourinary tract associated with altered expression patterns of the androgen and estrogen receptors in male rats

  Noritoshi Enatsu, K. Chiba, K. Sumii, T. Fukuda, K. Okada, K. Matsushita, M. Fujisawa

  We evaluated the effects of dutasteride on the genitourinary tract using fifteen 8-week-old male Sprague–Dawley rats. Animals were divided into three groups comprising five animals each and treated as follows. Group A was a control group, members of Group B received oral administration of dutasteride 0.1 mg/kg/day from the age of 8 to 16 weeks, and members of Group C were castrated at the age of 8 weeks. All rats were killed at the age of 16 weeks for the sample collection of blood, bladder, prostate, seminal vesicles, and penis. Then, we evaluated the pathological examination for evaluating the tissue fibrosis and hormonal receptor expression. The results showed that the mean size of the prostate and seminal vesicles was smaller in Group B and Group C than in Group A. Serum and tissue concentrations of both testosterone and dihydrotestosterone were remarkably reduced in serum and all tissues in Group C compared with Group A. On the other hand, in Group B, only dihydrotestosterone was reduced in serum and penis. Histopathological examination revealed that Group C showed statistically significant histological changes, such as an increase in fibrotic tissue in the bladder, prostate, and penis. Similarly, Group B showed fibrotic changes in the prostate and penis compared with the Group A. Immunofluorescent staining revealed that the androgen receptor was more strongly expressed than the estrogen receptor beta in Group A. On the other hand, in Group C, weak expression of the androgen receptor and strong expression of the estrogen receptor beta was noted. In Group B, these changes were noted in the prostate and penis. These findings suggest that dutasteride cause morphological changes not only in prostate but also in penis. These changes are associated with altered expression patterns of androgen receptor and estrogen receptor.

  Blackwell Publishing Ltd, Mar. 2017, Andrology, 5(2) (2), 347 - 353, English

  [Refereed]

  Scientific journal


• Effects of dutasteride on serum free-testosterone and clinical significance of testosterone changes

  N. Enatsu, H. Miyake, T. Haraguchi, K. Chiba, M. Fujisawa

  Sixty-two patients with benign prostate hyperplasia (BPH) who were being treated with dutasteride participated in this study. Prostate volume, uroflowmetry, blood tests, the International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF-5) were determined before and 1, 3 and 12 months after the treatment with dutasteride. Patients were divided into two groups based on changes in serum testosterone after 1 month: Group A (>20% increase; n = 33) or Group B (<20% increase; n = 29). Serum free-testosterone levels were 20.4% higher after 1 month and remained constant thereafter. When Groups A and B were compared, baseline free-testosterone levels were significantly lower in Group A, IPSS QOL was significantly better in Group A at 3 and 12 months, and no significant differences were observed in uroflowmetry, prostate volume, IPSS or IIEF-5. A univariate analysis identified serum free-testosterone levels and the IPSS storage symptom subscore as significant factors influencing IPSS QOL at 12 months, and only the IPSS storage symptom subscore appeared to be independently related to IPSS QOL. These results indicate that dutasteride increases serum free-testosterone levels in BPH patients, particularly with low baseline free-testosterone levels, and the increase in free-testosterone may have further add-on impacts on their urinary tract symptoms.

  WILEY-BLACKWELL, Dec. 2016, ANDROLOGIA, 48(10) (10), 1195 - 1201, English

  [Refereed]

  Scientific journal


• HoLEPの術者経験数別での手術成績・合併症に関する検討

  Shigemura Katsumi, 千葉公嗣, 福田輝雄, 江夏徳寿, 藤澤正人

  (一社)日本排尿機能学会, Dec. 2016, 日本排尿機能学会誌, 27(1) (1), 286 - 286, Japanese


• 経尿道的前立腺手術 HoLEPの術者経験数が手術成績・合併症に影響するかの検討

  Shigemura Katsumi, 福田輝雄, 江夏徳寿, 千葉公嗣, 藤澤正人

  (一社)日本泌尿器内視鏡学会, Nov. 2016, Japanese Journal of Endourology, 29(3) (3), 210 - 210, Japanese


• Characterization of urocortin as an anti-apoptotic protein in experimental ischemia-reperfusion model of the rat testis.

  Kenta Sumii, Hideaki Miyake, Noritoshi Enatsu, Koji Chiba, Masato Fujisawa

  The objective of this study was to investigate the role of urocortin in testicular apoptosis using an experimental ischemia-reperfusion rat model. To evaluate the change in urocortin expression and apoptotic status in the testes following ischemia-reperfusion, the left testes of rats were rotated clockwise by 720° for 1 h, and were then harvested at 0, 1, 3, 6 and 24 h after detorsion (n = 5 in each group). A time-dependent increase in the expression levels of urocortin was noted until 6 h after reperfusion, but the expression of urocortin was markedly decreased 24 h after reperfusion. However, a TUNEL assay showed that the proportion of germ cells undergoing apoptosis significantly increased 24 h after reperfusion compared with that of 6 h after reperfusion. To clarify whether or not urocortin directly regulates the testicular apoptosis induced by ischemia-reperfusion, either astressin, an antagonist of urocortin, or normal saline was injected into the rat testes 15 min before detorsion, followed by the testicular torsion. The testes were then removed 3 h after detorsion (n = 5 in each group). The testicular injection of astressin significantly increased the proportion of TUNEL-positive germ cells, and significantly decreased expression of Bcl-2 and Bcl-xL. In addition, the level of phosphorylated ERK 1/2, but not that of phosphorylated Akt, was significantly reduced by the intratesticular administration of astressin. These findings suggest that urocortin may play a cytoprotective role in the germ cells in response to ischemia-reperfusion injury through the activation of major anti-apoptotic proteins, as well as by the mitogen-activated protein kinase signaling pathway activation.

  ACADEMIC PRESS INC ELSEVIER SCIENCE, Oct. 2016, Biochemical and biophysical research communications, 479(2) (2), 387 - 392, English, International magazine

  [Refereed]

  Scientific journal


• Interposition of novel nerve-regeneration conduit after non nerve-sparing radical prostatectomy: Short-term results from a prospective trial

  Hinata Nobuyuki, Fujisawa Masato, Nakano Yuzo, Matsushita Kei, Ishimura Takeshi, Harada Kenichi, Furukawa Junya, Terakawa Tomoaki, Chiba Koji

  Jul. 2016, INTERNATIONAL JOURNAL OF UROLOGY, 23, 78

  [Refereed]


• RENAL FUNCTION AND PERIOPERATIVE OUTCOMES OF SELECTIVE VERSUS COMPLETE RENAL ARTERIAL CLAMPING DURING ROBOT-ASSISTED PARTIAL NEPHRECTOMY USING CONSOLE-INTEGRATED REAL-TIME THREE-DIMENSIONAL IMAGE OVERLAY NAVIGATION

  Furukawa Junya, Nishikawa Masatomo, Terakawa Tomoaki, Chiba Koji, Shigemura Katsumi, Harada Ken-ichi, Hinata Nobuyuki, Ishimura Takeshi, Matsushita Kei, Nakano Yuzo, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  Apr. 2016, JOURNAL OF UROLOGY, 195(4) (4), E566

  [Refereed]


• Comparison of Predictive Factors for Postoperative Incontinence of Holmium Laser Enucleation of the Prostate by the Surgeons' Experience During Learning Curve.

  Katsumi Shigemura, Kazushi Tanaka, Fukashi Yamamichi, Koji Chiba, Masato Fujisawa

  PURPOSE: To detect predictive factors for postoperative incontinence following holmium laser enucleation of the prostate (HoLEP) according to surgeon experience (beginner or experienced) and preoperative clinical data. METHODS: Of 224 patients, a total of 203 with available data on incontinence were investigated. The potential predictive factors for post-HoLEP incontinence included clinical factors, such as patient age, and preoperative urodynamic study results, including detrusor overactivity (DO). We also classified the surgeons performing the procedure according to their HoLEP experience: beginner (<21 cases) and experienced (≥21 cases). RESULTS: Our statistical data showed DO was a significant predictive factor at the super-short period (the next day of catheter removal: odds ratio [OR], 3.375; P=0.000). Additionally, patient age, surgeon mentorship (inverse correlation), and prostate volume were significant predictive factors at the 1-month interval after HoLEP (OR, 1.072; P=0.004; OR, 0.251; P=0.002; and OR, 1.008; P=0.049, respectively). With regards to surgeon experience, DO and preoperative International Prostate Symptom Score (inverse) at the super-short period, and patient age and mentorship (inverse correlation) at the 1-month interval after HoLEP (OR, 3.952; P=0.002; OR, 1.084; P=0.015; and OR,1.084; P=0.015; OR, 0.358; P=0.003, respectively) were significant predictive factors for beginners, and first desire to void (FDV) at 1 month after HoLEP (OR, 1.009; P=0.012) was a significant predictive factor for experienced surgeons in multivariate analysis. CONCLUSIONS: Preoperative DO, IPSS, patient age, and surgeon mentorship were significant predictive factors of postoperative patient incontinence for beginner surgeons, while FDV was a significant predictive factors for experienced surgeons. These findings should be taken into account by surgeons performing HoLEP to maximize the patient's quality of life with regards to urinary continence.

  KOREAN CONTINENCE SOC, Mar. 2016, International neurourology journal, 20(1) (1), 59 - 68, English, International magazine

  [Refereed]

  Scientific journal


• Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in the rat testis

  K. Matsushita, H. Miyake, K. Chiba, M. Fujisawa

  The objectives of this study were to determine whether the inhibition of clusterin expression in rat Sertoli cells enhances heat stress-induced apoptosis. The scrotums of rats were immersed in a water bath of 43 °C for 15 min. Testicular weight and germ cell number markedly decreased after the heat treatment in a time-dependent manner. In contrast, clusterin mRNA and protein expression levels were significantly up-regulated and peaked on day 21. The apoptotic index was markedly increased 1 day after the heat treatment. We then purified Sertoli cells from the rat testes, and an expression vector containing siRNA targeting the clusterin gene was transiently transfected into Sertoli cells. Following exposure to heat stress at 41 °C for 12 h, clusterin mRNA was markedly up-regulated after transfection with the control vector however, the transfection of siRNA targeting the clusterin resulted in > 70% reduction in the expression of clusterin mRNA. Furthermore, the apoptotic index in these Sertoli cells was significantly higher after the treatment with siRNA targeting the clusterin than control, and the most prominent difference was observed within 24 h after the heat treatment. These results suggest that an increase in the secretion of clusterin by Sertoli cells protects the testes from heat stress-induced injury.

  Blackwell Publishing Ltd, Feb. 2016, Andrologia, 48(1) (1), 11 - 19, English

  [Refereed]

  Scientific journal


• Identification of Spermatogenically Active Regions in Rat Testes by Using Narrow-band Imaging System.

  Noritoshi Enatsu, Hideaki Miyake, Koji Chiba, Masato Fujisawa

  OBJECTIVE: To evaluate the feasibility of narrow-band imaging (NBI) system in microdissection testicular sperm extraction (micro-TESE). MATERIALS AND METHODS: Firstly, we investigated angiogenic potential in human testicular specimens obtained from 48 patients who underwent micro-TESE. We then created a testicular injury model in rats with a single topical injection of cisplatin into the testes, and the testes were observed with and without NBI. To assess the relation between pathological changes and visual images, an immunofluorescence study of blood vessels in rat testes was carried out. We finally conducted an experiment that assumed micro-TESE by using a nonobstructive azoospermia (NOA) rat model induced by busulfan. RESULTS: The number of blood vessels in the specimens of hypospermatogenesis was significantly greater than that in the specimens of maturation arrest and Sertoli cell only. In rat testes, cisplatin caused atrophic changes, and significant differences in visual color between atrophic and normal lesions were noted using NBI. The number of seminiferous tubules with spermatozoa in atrophic regions was significantly lower than that in normal regions, and a significantly small number of blood vessels in atrophic regions was also noted compared with that in normal regions. NBI also identified patchy spermatogenesis in the busulfan-induced NOA rat model. CONCLUSION: An NBI system can distinguish spermatogenically active regions through the visualization of blood vessels in rat testes. This system may have the potential to provide useful information during micro-TESE for men with NOA.

  ELSEVIER SCIENCE INC, Nov. 2015, Urology, 86(5) (5), 929 - 35, English, International magazine

  [Refereed]

  Scientific journal


• Editorial Comment.

  Koji Chiba, Ranjith Ramasamy

  Jun. 2015, Urology, 85(6) (6), 1345 - 1345, English, International magazine


• Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin.

  Noritoshi Enatsu, Hideaki Miyake, Koji Chiba, Masato Fujisawa

  Nephrin and podocin are known to be closely related to the pharmacological effects of angiotensin-II receptor blocker (ARB). The objectives of this study were to investigate the role of nephrin and podocin using cisplatin-induced testicular damage and to evaluate the effect of ARB. At first, we evaluated the effects of cisplatin either alone or in combination with ARB candesartan on changes in expression patterns of nephrin and podocin in the rat testes. We then conducted in vitro studies to investigate the effects of angiotensin using cultured Sertoli cells, line TM4. As a result, the expression of nephrin and podocin was shown to localize around the basal membrane of seminiferous tubules. Treatment with cisplatin resulted in a marked decrease in the expression of nephrin and podocin and induced a shift of both proteins from linear to granular expression patterns, accompanying the increased apoptotic index in the testes; these changes were partially restored by the additional administration of candesartan. In vitro studies with TM4 revealed the angiotensin-II mediated expression changes of nephrin and podocin. These findings suggest that candesartan can prevent cisplatin-induced testicular damage by regulating expression patterns of the nephrin-podocin complex in the testes.

  HINDAWI LTD, 2015, BioMed research international, 2015, 273784 - 273784, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Impact of penile rehabilitation with low-dose vardenafil on recovery of erectile function in Japanese men following nerve-sparing radical prostatectomy

  Yuzo Nakano, Hideaki Miyake, Koji Chiba, Masato Fujisawa

  Erectile dysfunction (ED) is a major complication after radical prostatectomy (RP); however, debate continues regarding the efficacy of penile rehabilitation in the recovery of the postoperative erectile function (EF). This study included a total of 103 consecutive sexually active Japanese men with localized prostate cancer undergoing nerve-sparing RP, and analyzed the postoperative EF, focusing on the significance of penile rehabilitation. In this series, 24 and 79 patients underwent bilateral and unilateral nerve-sparing RPs, respectively, and 10 or 20 mg of vardenafil was administered to 35 patients at least once weekly, who agreed to undergo penile rehabilitation. Twelve months after RP, 48 (46.6%) of the 103 patients were judged to have recovered EF sufficient for sexual intercourse without any assistance. The proportion of patients who recovered EF in those undergoing penile rehabilitation (60.0%) was significantly greater than that in those without penile rehabilitation (38.2%). Of several parameters examined, the preoperative International Index of Erectile Function-5 (IIEF-5) score and nerve-sparing procedure were significantly associated with the postoperative EF recovery rates in patients with and without management by penile rehabilitation, respectively. Furthermore, univariate analysis identified the preoperative IIEF-5 score, nerve-sparing procedure and penile rehabilitation as significant predictors of EF recovery, among which the preoperative IIEF-5 score and nerve-sparing procedure appeared to be independently associated with EF recovery. Considering these findings, despite the lack of independent significance, penile rehabilitation with low-dose vardenafil could exert a beneficial effect on EF recovery in Japanese men following nerve-sparing RP.

  MEDKNOW PUBLICATIONS & MEDIA PVT LTD, Nov. 2014, ASIAN JOURNAL OF ANDROLOGY, 16(6) (6), 892 - 896, English

  [Refereed]

  Scientific journal


• 配偶子形成メカニズムの解明 精子形成とCell Junction

  Chiba Koji, 江夏 徳寿, 岡田 桂輔, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2014, 日本生殖医学会雑誌, 59(4) (4), 283 - 283, Japanese

  [Refereed]


• Achieved pregnancy with the delivery of a healthy child by TESE-ICSI 7 years after bilateral adult orchidopexy: a case report

  K. Matsushita, K. Yamaguchi, F. Li, K. Okada, M. Ando, K. Chiba, M. Koshida, H. Miyake, M. Fujisawa

  We report pregnancy with the delivery of a healthy child by TESE-ICSI 7 years after bilateral adult orchidopexy. A 29-year-old patient presented with infertility and previous bilateral cryptorchidism, but no surgical treatment had ever been performed. His partner had been assessed by a gynaecologist, and no contributing female factors were detected. Orchidopexy and conventional testicular sperm extraction (TESE) were performed and microdissection TESE 10 months after orchidopexy. The second microdissection TESE with intracytoplasmic sperm injection (ICSI) was performed 7 years after orchidopexy. The couple achieved pregnancy with the delivery of a healthy child by TESE-ICSI. It is concluded that bilateral orchidopexy in adulthood progresses spermatogenesis gradually, and microdissection TESE may succeed after a certain period of time following treatment.

  WILEY-BLACKWELL, Oct. 2014, ANDROLOGIA, 46(8) (8), 948 - 950, English

  [Refereed]

  Scientific journal


• Comprehensive evaluation of androgen replacement therapy in aging Japanese men with late-onset hypogonadism.

  Keisuke Okada, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  OBJECTIVE: This study assessed the efficacy and safety of testosterone replacement therapy (TRT) in aging Japanese men with late-onset hypogonadism (LOH). METHODS: This study included 50 (median age: 57.7 years) Japanese men with LOH, who were consecutively enrolled and treated with TRT for at least six months at our institution. We evaluated the following measurements before and after six months of treatment with TRT as follows: blood tests, prostate volume, residual urine volume, self-ratings for International Index of Erectile Function 5 (IIEF-5), International Prostate Symptom Score (IPSS), Self-Rating Depression Scale (SDS), Aging Male Symptom (AMS) and the Medical Outcomes Study 8-item Short-Form health survey (SF-8). RESULTS: Following six months of TRT, the levels of testosterone, red blood cells, hemoglobin and hematocrit were significantly increased from baseline, while total cholesterol level was significantly decreased from baseline. Furthermore, TRT led to a significant increase in IIEF-5 score and a significant decrease in IPSS score. Of 30 men who were diagnosed with depression at baseline, only 11 men (36.7%) were still suffering from depression after TRT, and SDS scores were significantly decreased from baseline at month six. Treatment with TRT led to a significant decrease in all scores of the AMS scale as well as a significant improvement in all scores of the SF-8 survey, with the exception of the bodily pain score. CONCLUSION: These findings suggest that TRT is an effective and safe treatment for aging Japanese men with LOH. TRT improved depressive symptoms as well as health-related quality of life.

  INFORMA HEALTHCARE, Jun. 2014, The aging male : the official journal of the International Society for the Study of the Aging Male, 17(2) (2), 72 - 5, English, International magazine

  [Refereed]

  Scientific journal


• Clinical outcome of microsurgical varicocelectomy in infertile men with severe oligozoospermia.

  Noritoshi Enatsu, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  OBJECTIVE: To evaluate the outcome of microsurgical varicocelectomy in infertile men with severe oligozoospermia and to identify the predictive parameters associated with the efficacy of microsurgical varicocelectomy in this cohort of patients. MATERIALS AND METHODS: This study included 102 consecutive severe oligozoospermic patients who underwent microsurgical varicocelectomy between 2000 and 2013. The significance of several parameters as predictors of response to microsurgical varicocelectomy was evaluated using univariate and multivariate analyses. Responders were defined as those who fulfilled the following criteria: (1) sperm motility rate improved after surgery and (2) sperm concentration increased from <1 × 10(6)/mL to ≥ 5 × 10(6)/mL or from 1-5 × 10(6)/mL to ≥ 10 × 10(6)/mL. RESULTS: After the mean postoperative observation period of 8.2 months, the mean sperm concentration increased from 2.4 to 11.6 million/mL (P <.001), and the mean sperm motility improved from 32.8% to 42.2% (P = .0024). There were no significant differences in the levels of hormonal parameters between the preoperative and postoperative measurements. Of the 102 patients, 42 (41.1%) were determined to be responders, and the wives of 17 (16.7%) conceived naturally. Univariate analysis identified preoperative sperm concentration (≥ 2.0 vs <2.0 million/mL) and laterality of varicocele (bilateral vs unilateral) as significant predictors of response to varicocelectomy. Only preoperative sperm concentration appeared to be independently related to the efficacy of varicocelectomy in men with severe oligozoospermia on multivariate analysis. CONCLUSION: Varicocelectomy may improve the sperm quality and fertility potential in men with severe oligozoospermia, particularly for those with relatively high sperm concentration.

  ELSEVIER SCIENCE INC, May 2014, Urology, 83(5) (5), 1071 - 4, English, International magazine

  [Refereed]

  Scientific journal


• Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis.

  Keisuke Okada, Hideaki Miyake, Kohei Yamaguchi, Koji Chiba, Kazuhiro Maeta, Shymaa E Bilasy, Hironori Edamatsu, Tohru Kataoka, Masato Fujisawa

  Small GTPase Rap1 has been implicated in the proper differentiation of testicular germ cells. In the present study, we investigated the functional significance of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in testicular differentiation using mice lacking RA-GEF-2. RA-GEF-2 was expressed predominantly on the luminal side of the seminiferous tubules in wild-type mice. No significant differences were observed in the body weights or hormonal parameters of RA-GEF-2(-)(/)(-) and wild-type mice. However, the testes of RA-GEF-2(-)(/)(-) male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic. The concentration and motility of epididymal sperm were also markedly reduced and frequently had an abnormal shape. The pregnancy rate and number of fetuses were markedly lower in wild-type females after they mated with RA-GEF-2(-)(/)(-) males than with wild-type males, which demonstrated the male infertility phenotype of RA-GEF-2(-)(/)(-) mice. Furthermore, a significant reduction and alteration were observed in the expression level and cell junctional localization of N-cadherin, respectively, in RA-GEF-2(-)(/)(-) testes, which may, at least in part, account for the defects in testicular differentiation and spermatogenesis in these mice.

  ACADEMIC PRESS INC ELSEVIER SCIENCE, Feb. 2014, Biochemical and biophysical research communications, 445(1) (1), 89 - 94, English, International magazine

  [Refereed]

  Scientific journal


• 卵巣奇形腫に対して発症早期に腹腔鏡手術を施行し経過良好であった抗NMDAR抗体関連脳炎の１症例

  Kumano Masafumi, 蝦名 康彦, Kumano Masafumi, Yamaguchi Kohei, Chiba Koji, Tamiya Hiroko, Kido Yoshiaki, Junya Furukawa, 宮崎 彰, 山崎 友維, 藤澤正人, Kenichi Harada, 鄭 裕元, 白川 得朗, Mototsugu Muramaki, 西川昌友, 牧原 夏子, Hideaki Miyake, 宮原 義也, 古川順也, Masato Fujisawa, 原田健一, 新谷 潔, 中林 幸士, 日向信之, 松岡 正造, 村蒔基次, 三宅秀明, 上中建, 横田 一郎, 藤澤正人, 苅田 典生, 田中 惠, Yamada Hideto

  2014, 日本産科婦人科内視鏡学会雑誌, 40, Japanese

  [Refereed]

  Scientific journal


• 背景腎にMixed epithelial and stromal tumorを認めた腎細胞癌の1例

  Tanaka Kazushi, Kawakami Fumi

  泌尿器科紀要刊行会, Dec. 2013, 泌尿器科紀要, 59(12) (12), 804 - 804, Japanese


• ダビンチSシステムを用いたロボット支援腹腔鏡下腎部分切除術 選択的動脈遮断による部分阻血法

  Shigemura Katsumi, Tanaka Kazushi

  泌尿器科紀要刊行会, Sep. 2013, 泌尿器科紀要, 59(9) (9), 623 - 623, Japanese

  [Refereed]


• ロボット支援腹腔鏡下腎部分切除術(RALPN)の治療成績

  Tanaka Kazushi, Shigemura Katsumi

  泌尿器科紀要刊行会, Sep. 2013, 泌尿器科紀要, 59(9) (9), 623 - 623, Japanese

  [Refereed]


• Outcome of microdissection testicular sperm extraction in azoospermic patients with Klinefelter syndrome and other sex-chromosomal anomalies.

  Makoto Ando, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  It has been indicated that approximately 20% of azoospermic patients have chromosomal anomalies, 90% of which are sex-chromosome abnormalities. Even azoospermic patients with sex-chromosomal anomalies might be able to father children using an advanced assisted reproductive technique such as microdissection testicular sperm extraction (micro-TESE) with intracytoplasmic sperm injection (ICSI). To evaluate the effect of micro-TESE in azoospermic patients with various sex-chromosomal anomalies, we reviewed their clinical results. A chromosomal survey using the G-banding technique was performed on males whose semen analysis demonstrated azoospermia at the Division of Male Infertilities at our institution between January 2004 and December 2009. Forty-two of these subjects demonstrated sex-chromosomal anomalies. The mean patient age was 34.4 ± 4.3 years. We classified them into two groups: Klinefelter syndrome (47,XXY) and other sex-chromosome abnormalities. Thirty-five patients showed Klinefelter syndrome and seven patients showed other sex-chromosome abnormalities. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were 36.3 ± 14.0 IU/L, 15.8 ± 6.7 IU/L, and 3.2 ± 2.0 ng/ml in Klinefelter syndrome, and 20.8 ± 10.4 IU/L, 8.2 ± 5.2 IU/L and 4.1 ± 1.5 ng/ml in other sex-chromosome abnormalities, respectively. The mean testicular volume was 4.0 ± 2.1 ml in Klinefelter syndrome and 9.9 ± 4.6 ml in other sex-chromosome abnormalities. Serum FSH and LH in Klinefelter syndrome were significantly higher than those in other sex-chromosome abnormalities, and the mean testicular volume in Klinefelter syndrome was significantly smaller than that in other sex-chromosome abnormalities. The sperm retrieval rate (SRR) for micro-TESE showed no significant difference between the two groups (42.4% vs. 42.9%). In this study, the outcome of micro-TESE appeared not to differ between Klinefelter syndrome and other sex-chromosome abnormalities.

  Aug. 2013, Systems biology in reproductive medicine, 59(4) (4), 210 - 3, English, International magazine

  [Refereed]

  Scientific journal


• 総テストステロン値別による加齢男性性腺機能低下症候群患者の治療効果の検討

  Tanaka Kazushi

  (一社)日本抗加齢医学会, Jun. 2013, 日本抗加齢医学会総会プログラム・抄録集13回, 13回, 228 - 228, Japanese


• 総テストステロン値別による加齢男性性腺機能低下症候群患者の治療効果の検討

  Chiba Koji, 山口 耕平, 李 福平, 江夏 徳寿, 岡田 桂輔, 松下 経, 三宅 秀明, 田中 一志, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 294 - 294, Japanese


• 精子形成障害の新たなメカニズムの解明 RA-GEF-2ノックアウトマウスを用いたオス不妊マウスの精子形成能の評価

  Chiba Koji

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 170 - 170, Japanese


• Efficient transfection of DNA into primarily cultured rat sertoli cells by electroporation.

  Fuping Li, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Noritoshi Enatsu, Koji Chiba, Huanxun Yue, Masato Fujisawa

  The expression of exogenous DNA in Sertoli cells is essential for studying its functional genomics, pathway analysis, and medical applications. Electroporation is a valuable tool for nucleic acid delivery, even in primarily cultured cells, which are considered difficult to transfect. In this study, we developed an optimized protocol for electroporation-based transfection of Sertoli cells and compared its efficiency with conventional lipofection. Sertoli cells were transfected with pCMV-GFP plasmid by square-wave electroporation under different conditions. After transfection of plasmid into Sertoli cells, enhanced green fluorescent protein (EGFP) expression could be easily detected by fluorescent microscopy, and cell survival was evaluated by dye exclusion assay using Trypan blue. In terms of both cell survival and the percentage expressing EGFP, 250 V was determined to produce the greatest number of transiently transfected cells. Keeping the voltage constant (250 V), relatively high cell survival (76.5% ± 3.4%) and transfection efficiency (30.6% ± 5.6%) were observed with a pulse length of 20 μm. The number of pulses significantly affected cell survival and EGFP expression (P < 0.001). Cell survival clearly decreased following one to three pulses, from 83.9% ± 6.1% to 3.2% ± 1.1%, with EGFP expression increasing from 41.8% ± 9.4% to 66.7% ± 5.2%. The yield of positive cells increased with increasing concentration of plasmid DNA (range, 10-50 μg/ml), from 14.0% ± 2.8% to 35.0% ± 6.3%, but cell viability steadily decreased following 20 μg/ml plasmid DNA, from 73.1% ± 4.9% to 57.0% ± 6.6%. Compared with two popular cationic lipid transfection methods, the transfection efficiency of electroporation (21.5% ± 5.7%) was significantly higher than those of Lipofectamine 2000 (2.9% ± 1.0%) and Effectene (1.9% ± 0.8%) in this experiment (P < 0.001). We describe the process of optimizing electroporation conditions, and the successful electroporation of plasmid DNA into primarily cultured Sertoli cells. Our results indicate that the method of electroporation is more suitable than other approaches for the transfection of Sertoli cells.

  SOC STUDY REPRODUCTION, Mar. 2013, Biology of reproduction, 88(3) (3), 61 - 61, English, International magazine

  [Refereed]

  Scientific journal


• 術前診断に3T-MRIを用いたロボット支援前立腺全摘除術の成績

  Tanaka Kazushi, Shigemura Katsumi, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Furukawa Jyunya, Ishimura Takeshi, Haraguchi Takahiro, Muramaki Mototsugu, Takahashi Satoru, Miyake Hideaki, Fujisawa Masato

  (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 717 - 717, Japanese

  [Refereed]


• 抗凝固療法中の前立腺肥大症患者に対するHoLEPの有用性について

  Haraguchi Takahiro, Miyake Hideaki, Chiba Koji, Tanaka Kazushi, Fujisawa Masato

  (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 743 - 743, Japanese


• 陰茎持続勃起症の8例

  Chiba Koji, Yamaguchi Kohei, Nakano Yuzo, Miyake Hideaki, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato

  (一社)日本性機能学会, Dec. 2012, 日本性機能学会雑誌, 27(3) (3), 273 - 273, Japanese


• ロボット手術の適応と将来展望 選択的腎阻血を行ったロボット支援腹腔鏡下腎部分切除術の検討

  Tanaka Kazushi, Furukawa Jyunya, Shigemura Katsumi, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Ishimura Takeshi, Haraguchi Takahiro, Sugimoto Maki, Muramaki Mototsugu, Miyake Hideaki, Fujisawa Masato

  (一社)日本内視鏡外科学会, Dec. 2012, 日本内視鏡外科学会雑誌, 17(7) (7), 241 - 241, Japanese


• 神戸大学病院におけるHoLEPの臨床的検討

  Chiba Koji, Haraguchi Takahiro, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  (一社)日本泌尿器内視鏡学会, Nov. 2012, Japanese Journal of Endourology, 25(3) (3), 275 - 275, Japanese


• ダビンチSシステムを用いたロボット支援腹腔鏡下腎部分切除術 選択的動脈遮断による部分阻血法

  Furukawa Jyunya, Yamaguchi Kohei, Chiba Koji, Shigemura Katsumi, Ishimura Takeshi, Muramaki Mototsugu, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  (一社)日本泌尿器内視鏡学会, Nov. 2012, Japanese Journal of Endourology, 25(3) (3), 208 - 208, Japanese

  [Refereed]


• Pure laparoscopic surgeryからhand-assisted surgeryへの変更を要した腹腔鏡下根治的腎摘除術の検討

  Yamaguchi Kohei, Miyake Hideaki, Chiba Koji, Furukawa Jyunya, Ishimura Takeshi, Muramaki Mototsugu, Haraguchi Takahiro, Tanaka Kazushi, Fujisawa Masato

  (一社)日本泌尿器内視鏡学会, Nov. 2012, Japanese Journal of Endourology, 25(3) (3), 291 - 291, Japanese


• Expression pattern of testicular claudin-11 in infertile men.

  Koji Chiba, Kohei Yamaguchi, Makoto Ando, Hideaki Miyake, Masato Fujisawa

  OBJECTIVE: To investigate the expression levels of claudin-11 mRNA and the localization of claudin-11 protein in testes of infertile men. METHODS: This study included 5 men with obstructive azoospermia and 50 men with nonobstructive azoospermia who had undergone testicular sperm extraction. Testicular tissues were obtained from these men and expression levels of claudin-11 mRNA in testicular samples were determined by real-time reverse transcription-polymerase chain reaction. The localization of claudin-11 protein was analyzed by immunofluorescent staining. RESULTS: Expression levels of testicular claudin-11 mRNA in nonobstructive azoospermia men were significantly greater than in obstructive azoospermia men, whereas there was no significant difference in testicular claudin-11 mRNA expression between men with and without successful sperm retrieval by testicular sperm extraction. Based on the findings of immunofluorescent staining, expression patterns of claudin-11 protein could be divided into normal (localization to basal component of seminiferous tubules) and abnormal patterns (diffuse expression in Sertoli cells/extremely low or no expression). The proportion of nonobstructive azoospermia men with an abnormal expression pattern of claudin-11, particularly that of Sertoli cell-only syndrome men, was significantly greater than that of obstructive azoospermia men. Furthermore, claudin-11 expression showing an abnormal pattern in men without successful sperm retrieval was significantly frequent compared with those whose sperm were successfully retrieved. CONCLUSION: These findings suggest that disorganization of claudin-11 expression in Sertoli cells might be one of the factors involved in the impairment of spermatogenesis.

  ELSEVIER SCIENCE INC, Nov. 2012, Urology, 80(5) (5), 1161.e13-7, English, International magazine

  [Refereed]

  Scientific journal


• 非閉塞性無精子症患者における精子回収とストレス関連タンパクの発現

  Matsushita Kei, Yamaguchi Kohei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本生殖医学会, Oct. 2012, 日本生殖医学会雑誌, 57(4) (4), 335 - 335, Japanese


• 精巣adrenal rest tumorを伴った21水酸化酵素欠損症に合併した乏精子症の一例

  Chiba Koji, Yamaguchi Kohei, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  (一社)日本生殖医学会, Oct. 2012, 日本生殖医学会雑誌, 57(4) (4), 440 - 440, Japanese


• 腎癌に対するロボット支援腹腔鏡下腎部分切除術の治療成績

  Tanaka Kazushi, Furukawa Jyunya, Shigemura Katsumi, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Ishimura Takeshi, Haraguchi Takahiro, Muramaki Mototsugu, Miyake Hideaki, Fujisawa Masato

  (一社)日本癌治療学会, Oct. 2012, 日本癌治療学会誌, 47(3) (3), 2555 - 2555, Japanese


• 思春期および子供の精巣静脈瘤患者に対する精索静脈瘤手術が精巣容量に与える影響

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本生殖医学会, Oct. 2012, 日本生殖医学会雑誌, 57(4) (4), 437 - 437, Japanese


• マウス精子形成におけるRA-GEF-2のノックアウトマウスを用いた機能解析

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, EL-SHAWADFYMOHAMED BILASY SHYMAA, Edamatsu Hironori, Kataoka Tohru

  (一社)日本生殖医学会, Oct. 2012, 日本生殖医学会雑誌, 57(4) (4), 327 - 327, Japanese


• Significant improvement of sperm DNA quality after microsurgical repair of varicocele.

  Fuping Li, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Makoto Ando, Koji Chiba, Huanxun Yue, Masato Fujisawa

  Varicocele is currently the most common irregularity identified in males that is associated with impaired spermatogenesis. It primarily presents in the form of decreased sperm count and motility, abnormal morphology, and significantly increased sperm DNA fragmentation. Several studies have shown that surgical repair improves semen parameters and increases the odds of spontaneous pregnancy. However the exact effect of surgical repair treatment remains controversial. Therefore, the aim of our study was to evaluate the effectiveness of microsurgical repair by comparing common semen parameters and sperm DNA fragmentation index (DFI). We evaluated infertile men (n = 19) who underwent microsurgical subinguinal varicocelectomy for treatment of clinical varicocele before and 3 months after surgery. Normozoospermic men (n = 19) were considered as the normal control group. Semen parameters improved significantly after surgery when compared with that before surgery, but still significant differences with the normal control group were observed. In comparison, sperm DNA integrity improved significantly after surgery (percentage DFI decreased from 28.4 ± 15.6% before surgery to 22.4 ± 12.9%, at 3 months post surgery) to similar levels as the normal control group. These results suggest that microsurgical repair may be considered as a treatment option in infertile men with palpable varicocele.

  INFORMA HEALTHCARE, Oct. 2012, Systems biology in reproductive medicine, 58(5) (5), 274 - 7, English, International magazine

  [Refereed]

  Scientific journal


• 排尿障害患者におけるデュタステリド内服療法の性機能および血中テストステロン値への影響についての検討

  Chiba Koji, Nakano Yuzo, Haraguchi Takahiro, Shirakawa Toshiro, Tanaka Kazushi, Arakawa Soichi, Fujisawa Masato

  (一社)日本性機能学会, Sep. 2012, 日本性機能学会雑誌, 27(2) (2), 175 - 175, Japanese


• マウス精子形成におけるRA-GEF-2のノックアウトマウスを用いた機能解析

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, EL-SHAWADFYMOHAMED BILASY SHYMAA, Edamatsu Hironori, Kataoka Tohru

  (一社)日本内分泌学会, Sep. 2012, 日本内分泌学会雑誌, 88(2) (2), 735 - 735, Japanese


• 経尿道的射精管開放術(TUR-ED)にて精液所見が著明に改善した部分射精管閉塞の1例

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本生殖医学会, Jul. 2012, 日本生殖医学会雑誌, 57(3) (3), 118 - 119, Japanese


• Expression of VASA mRNA in Testis as a Significant Predictor of Sperm Recovery by Microdissection Testicular Sperm Extraction in Patient With Nonobstructive Azoospermia

  Makoto Ando, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  It would be of value to evaluate whether expression levels of mRNAs playing important roles in spermatogenesis could be used as predictors of successful testicular sperm recovery by microdissection testicular sperm extraction (TESE) in patients with nonobstructive azoospermia (NOA). This study included 52 patients with NOA who underwent therapeutic sperm retrieval by micro-TESE at our institution. We measured expression levels of VASA, outer dense fiber-1 (ODF1), ODF2, and sperm mitochondria-associated cysteine-rich protein (SMCP) mRNAs in testicular tissue specimens obtained from these patients by quantitative real-time reverse transcription polymerase chain reaction. Expression patterns of these mRNAs were analyzed focusing on the outcomes of sperm retrieval by micro-TESE. There were no significant differences in age, testicular volume, and serum levels of follicle-stimulating hormone, luteinizing hormone, and testosterone between successful and unsuccessful TESE groups; however, the proportion of patients with Sertoli cell only in the successful TESE group was significantly lower than that in the unsuccessful TESE group. Additionally, expression levels of VASA, ODF1, ODF2, and SMCP mRNAs in the successful TESE group were significantly greater than those in the unsuccessful TESE group. Univariate analysis identified histological classification, VASA, ODF1, ODF2, and SMCP expressions as significant predictors of sperm retrieval, of which only VASA mRNA expression appeared to be independently related to micro-TESE outcome on multivariate analysis. These findings suggest that measurement of VASA mRNA in testis could be a useful adjunct to conventional parameters for predicting sperm retrieval by micro-TESE in patients with NOA.

  AMER SOC ANDROLOGY, INC, Jul. 2012, JOURNAL OF ANDROLOGY, 33(4) (4), 711 - 716, English

  [Refereed]

  Scientific journal


• LOH症候群患者に対する男性ホルモン補充療法の有用性に関する検討

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本抗加齢医学会, Jun. 2012, 日本抗加齢医学会総会プログラム・抄録集12回, 12回, 178 - 178, Japanese


• Effect of varicocelectomy on testicular volume in children and adolescents: a meta-analysis.

  Fuping Li, Koji Chiba, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Makoto Ando, Huanxun Yue, Masato Fujisawa

  OBJECTIVE: To evaluate the effect of surgical intervention on catch-up growth as determined by a decreased testicular volume discrepancy in children and adolescents with varicocele. METHODS: A systematic search was performed using MEDLINE and the PubMed database and cross-referenced as of October 28, 2011 using the terms "varicocele," "children," "adolescent," "surgery," and "testicular volume." All relevant studies were of the testicular volume discrepancy variance before and after surgical repair. The outcomes included the number of patients with initial testicular atrophy and those with catch-up growth after surgical repair. The database search, quality evaluation, and data extraction were independently performed by 2 reviewers. RESULTS: Of 75 studies, 14 were included for analysis and involved 1475 patients. The combined analysis showed that the testicular volume discrepancy was significantly reduced after surgery in the ≥10% group (P < .00001) and ≥20% group (P < .00001), respectively. No difference was found between the 2 groups (P = .70). Taken together, the number of patient with testicular volume disproportion in all pediatric and adolescent varicocele patients significantly decreased after surgery (P < .00001). The average proportion of catch-up growth was 76.4% (range 52.6%-93.8%). CONCLUSION: The meta-analysis suggested clear advantages of surgical intervention on reducing testicular hypotrophy when the discrepancy is ≥10% in children and adolescents with varicocele. Additional prospective and controlled studies are warranted to elucidate the treatment of children and adolescents with varicocele.

  ELSEVIER SCIENCE INC, Jun. 2012, Urology, 79(6) (6), 1340 - 5, English, International magazine

  [Refereed]

  Scientific journal


• ロボット支援前立腺全摘除術における術前3T-MRIの有用性の検討

  田中 一志, 村蒔 基次, 山口 耕平, 松本 穣, 千葉 公嗣, Shigemura Katsumi, 古川 順也, 石村 武志, 原口 貴裕, 中野 雄造, Takahashi Satoru, 三宅 秀明, 藤澤 正人

  (一社)日本内分泌外科学会, May 2012, 日本内分泌外科学会総会プログラム・抄録集24回, 24回, 91 - 91, Japanese


• Inhibition of Claudin-11 and Occludin Expression in Rat Sertoli Cells by Mono-(2-Ethylhexyl) Phthalate Through p44/42 Mitogen-Activated Protein Kinase Pathway

  Koji Chiba, Yutaka Kondo, Kohei Yamaguchi, Hideaki Miyake, Masato Fujisawa

  Our objectives were to evaluate the effects of mono(2-ethylhexyl) phthalate (MEHP) on tight junctions (TJ) in cultured rat Sertoli cells (SC) and to investigate changes in the signal transduction pathways in SCs following MEHP treatment. SCs were isolated and purified from the testes of 18-day-old Sprague Dawley rats and incubated at 34 degrees C for 3 days. After treatment of SCs with either the vehicle or MEHP for 0.5, 1, 3, 6 and 24 hours, whole cell lysates were isolated from each replicate to prepare RNA and protein. Expression levels of claudin-11, occludin, and zonula occludens-1 (ZO-1) mRNA were evaluated by quantitative real-time reverse transcription polymerase chain reaction and changes in signal transduction pathways possibly induced by MEHP treatment were assessed by Western blot analyses. MEHP treatment led to significant decreases in the expression of claudin-11 and occludin mRNA, but not that of ZO-1, in rat SCs. Exposure of rat SCs to MEHP resulted in the marked induction of phosphorylated p44/42 mitogen-activated protein kinase (MARK), whereas other pathways examined in this study were not activated by MEHP. Furthermore, treatment of rat SCs with a specific inhibitor of p44/42 MARK prevented the MEHP-induced down-regulation of claudin-11 and occludin. These findings demonstrate that MEHP exposure inhibited the expression of claudin-11 and occludin mRNA in rat SCs through the p44/42 MARK pathway, suggesting the possible involvement of MEHP in spermatogenic function by regulating major components of TJs in SCs.

  AMER SOC ANDROLOGY, INC, May 2012, JOURNAL OF ANDROLOGY, 33(3) (3), 368 - 374, English

  [Refereed]

  Scientific journal


• 精索静脈瘤患者における術前後のテストステロン産生能に関する検討 メタ分析

  Matsushita Kei, Yamaguchi Kohei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本泌尿器科学会, Mar. 2012, 日本泌尿器科学会雑誌, 103(2) (2), 524 - 524, Japanese


• 精液検査異常を伴う精索静脈瘤患者の術後経時的変化に関する検討

  Chiba Koji, Yamaguchi Kohei, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  (一社)日本泌尿器科学会, Mar. 2012, 日本泌尿器科学会雑誌, 103(2) (2), 523 - 523, Japanese


• 顕微鏡下精巣内精子採取術307例の検討

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本泌尿器科学会, Mar. 2012, 日本泌尿器科学会雑誌, 103(2) (2), 523 - 523, Japanese


• 経尿道的射精管開放術(TUR-ED)によって精液所見が著明に改善した射精管部分閉塞の1例

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本泌尿器科学会, Mar. 2012, 日本泌尿器科学会雑誌, 103(2) (2), 524 - 524, Japanese


• LOH症候群患者における症状と血中遊離型テストステロン値との相関についての検討

  Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  (一社)日本泌尿器科学会, Mar. 2012, 日本泌尿器科学会雑誌, 103(2) (2), 516 - 516, Japanese


• Effect of surgical repair on testosterone production in infertile men with varicocele: a meta-analysis.

  Fuping Li, Huanxun Yue, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Makoto Ando, Koji Chiba, Masato Fujisawa

  OBJECTIVES: To determine the effect of surgical varicocele repair in improving testicular Leydig cell function as shown by increased testosterone production. METHODS: Eligible studies were searched in Medline and the Pubmed database, and cross-referenced as of 31 May 2011 using the terms "varicocele,"testosterone" and "surgery." The database search, quality assessment and data extraction were independently carried out by two reviewers. Only studies including patients with testosterone evaluation before and after surgery were considered for the analysis. A systematic review and meta-analysis was carried out for continues variables using random effect models. RESULTS: Out of 125 studies, a total of nine were selected, including 814 patients. The combined analysis showed that mean serum testosterone levels after surgical treatment increased by 97.48 ng/dL (95% confidence interval 43.73-151.22, P=0.0004) compared with preoperative levels. CONCLUSIONS: Surgical treatment of varicocele significantly increases testosterone production and improves testicular Leydig cell function.

  WILEY-BLACKWELL, Feb. 2012, International journal of urology : official journal of the Japanese Urological Association, 19(2) (2), 149 - 54, English, International magazine

  [Refereed]

  Scientific journal


• Molecular changes induced by bisphenol-A in rat Sertoli cell culture.

  Yoko Izumi, Kohei Yamaguchi, Tomomoto Ishikawa, Makoto Ando, Koji Chiba, Hiromi Hashimoto, Masahide Shiotani, Masato Fujisawa

  Bisphenol-A (BPA) is an industrial chemical and is known to act as an endocrine disrupter. This study was designed to evaluate how BPA regulates Sertoli cell (SC) signal molecules. Purified rat SCs were cultured and treated with BPA (200 µmol/l) at various time points. Western blot analysis was used to determine the activation of extracellular signal-related kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinase (JNK), p38 mitogen activated protein kinase (MAPK), nuclear factor kappa B (NF-κB), cyclooxygenase-1,2 (COX-1, 2), estrogen receptor-α (ER-α), and androgen receptor (AR). The levels of transferrin (TF), prostaglandin E(2) (PGE(2)), and prostaglandin F(2α) (PGF(2α)) in culture medium were quantified by ELISA. Interleukin (IL)-1β and IL-6 mRNAs were measured by quantitative real-time PCR (QRT-PCR). Compared with the control, BPA activated the phosphorylation of ERK1/2 (p-ERK1/2) through 30 min to 6 h. TF was down-regulated at 6 and 24 h. Furthermore, IL-1β was up-regulated at 30 min and IL-6 was up-regulated at 1 and 24 h. ERK activity inhibitor (PD98059, 10 µmol/l) inhibited these molecular changes. These results reveal the possibility that BPA may have adverse effects on spermatogenesis via ERK1/2.

  INFORMA HEALTHCARE, Oct. 2011, Systems biology in reproductive medicine, 57(5) (5), 228 - 32, English, International magazine

  [Refereed]

  Scientific journal


• The efficacy of androgen replacement therapy in men with late-onset hypogonadism

  Kohei Yamaguchi, Makoto Ando, Koji Chiba, Li Fuping, Masato Fujisawa

  Background: Late-onset hypogonadism (LOH) is defined as subnormal serum testosterone (T) levels in connection with an array of physical, psychic and sexual symptoms, generally related to male hypogonadism. Recent studies show that it is generally recognized that serum T, in normal range, has important roles for prevention of the onset of adult disease such as diabetes mellitus. Therefore, we have actively provided LOH patients with androgen replacement therapy (ART). Objective: The objective of this study was to clinically assess the efficacy and side effects of ART in men with LOH. Methods: The study included 64 patients diagnosed with LOH and treated with ART at least as long as 6 months at our institution. Questionnaires with age, aging male symptom (AMS) scale, and androgen decline in the aging male (ADAM) were examined. Fasting blood samples were analyzed for sex hormones, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gamma-GTP), red blood cell count (RBC), hemoglobin (Hb), hematocrit (Ht), prostate-specific antigen (PSA) and plasma glucose. Results: Psychological and physical symptoms scores, measured by the AMS scale and the ADAM questionnaire, were significantly improved after ART (P < 0.05). TC, HDL and LDL cholesterol, TG, AST, ALT, gamma-GTP, and plasma glucose were not significantly different before and after the therapy. Conclusions: ART for men with LOH may cause favorable changes in psychological and physical conditions. However, further investigations are necessary to determine long-term effects of the therapy. (c) 2011 WPMH GmbH. Published by Elsevier Ireland Ltd. All rights reserved.

  ELSEVIER IRELAND LTD, Apr. 2011, JOURNAL OF MENS HEALTH, 8, S46 - S49, English

  [Refereed]

  Scientific journal


• Finasteride-associated male infertility.

  Koji Chiba, Kohei Yamaguchi, Fuping Li, Makoto Ando, Masato Fujisawa

  OBJECTIVE: To describe a male patient with finasteride-associated infertility. DESIGN: Case report. SETTING: Tertiary-care clinic for male infertility. PATIENT(S): A patient with azoospermia who had been taking finasteride (1-mg dose) for 1 year for androgenic alopecia. He had been diagnosed with oligospermia 5 years before. INTERVENTION(S): Discontinuation of finasteride. MAIN OUTCOME MEASURE(S): Improvement of semen parameters. RESULT(S): After cessation of finasteride, the patient's semen volume increased immediately, and sperm concentration was up to more than 10 × 10(6)/mL 16 weeks after stopping finasteride. He is now trying to achieve pregnancy by intrauterine insemination. CONCLUSION(S): Cessation of finasteride improved spermatogenesis and allowed the couple to attempt less-invasive fertility therapy. In this case, the patient had impaired spermatogenesis before he started the drug. In such patients, the drug may further decrease spermatogenesis. We suggest that drug cessation could be taken into consideration for infertile male patients with impaired semen parameters who are taking finasteride at a 1-mg dose.

  ELSEVIER SCIENCE INC, Apr. 2011, Fertility and sterility, 95(5) (5), 1786.e9-11, English, International magazine

  [Refereed]

  Scientific journal


• Assessment of possible effects for testosterone replacement therapy in men with symptomatic late-onset hypogonadism

  K. Yamaguchi, T. Ishikawa, K. Chiba, M. Fujisawa

  P>We herein report clinical assessments of efficacy and side effects of T replacement therapy (TRT) in men with late-onset hypogonadism (LOH). The study included 56 patients who were diagnosed with LOH and treated with TRT for at least 6 months at our institution. Age, ageing male symptom (AMS) scale, and androgen decline in the ageing male (ADAM) questionnaires were examined. Fasting blood samples were analysed for sex hormones, total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gamma-GTP), red blood cell count (RBC), haemoglobin (Hb), haematocrit (Ht), and prostate-specific antigen (PSA). Total and psychological symptoms scores were measured by the AMS scale and the ADAM questionnaire score, demonstrating that the sum of positive responses to the questions were significantly improved after TRT (P < 0.05). TC, HDL, and LDL cholesterol, TG, AST, ALT, gamma-GTP, RBC, Hb, Ht, and PSA were not significantly different between before and after TRT. Although TRT for men with LOH may cause favorable changes in psychological conditions, it may not have effects on lipid metabolism, liver function, RBC, and PSA level.

  WILEY-BLACKWELL PUBLISHING, INC, Feb. 2011, ANDROLOGIA, 43(1) (1), 52 - 56, English

  [Refereed]

  Scientific journal


• Learning curves of microdissection testicular sperm extraction for nonobstructive azoospermia.

  Tomomoto Ishikawa, Ryuichiro Nose, Kohei Yamaguchi, Koji Chiba, Masato Fujisawa

  OBJECTIVES: Microdissection testicular sperm extraction (micro-TESE) has been performed at some experienced male infertility centers. Micro-TESE in patients with nonobstructive azoospermia (NOA) has been shown to be not only feasible and safe but also a technically demanding operation. To evaluate whether the improvement of surgical outcomes of micro-TESE, we hereby report the learning curves of micro-TESE for NOA patients. DESIGN: Retrospective clinical analysis. SETTING: Male infertility center. PATIENT(S): Since 2006, micro-TESE was performed in 150 patients with NOA by a single surgeon. INTERVENTION(S): After the tunica albuginea was opened, direct examination of the testicular parenchyma was performed at x25 magnification. MAIN OUTCOME MEASURE(S): Sperm retrieval rate and clinical factors in the first 50 patients (group A), the middle 50 patients (group B), and the last 50 patients (group C) were examined. RESULT(S): There were no differences in clinical factors among the three groups. Total operation times were shorter in group B and C than in group A (P<0.05). The sperm retrieval rate in group B (44%) and C (48%) was significantly higher than in group A (32%; P<0.05). CONCLUSION(S): As cases increase, surgical outcomes and sperm retrieval rate have improved. We think that this report showed substantial learning curves for a microscopic surgery such as micro-TESE.

  ELSEVIER SCIENCE INC, Aug. 2010, Fertility and sterility, 94(3) (3), 1008 - 11, English, International magazine

  [Refereed]

  Scientific journal


• Serum hormones in patients with nonobstructive azoospermia after microdissection testicular sperm extraction.

  Tomomoto Ishikawa, Kohei Yamaguchi, Koji Chiba, Atsushi Takenaka, Masato Fujisawa

  PURPOSE: Microdissection testicular sperm extraction combined with intracytoplasmic sperm injection is currently used to treat infertility in cases of nonobstructive azoospermia. Even in patients with nonmosaic Klinefelter's syndrome, who usually present with small testes and hypogonadism, the procedure has been done successfully. We assessed serum hormones after microdissection testicular sperm extraction and compared postoperative testicular damage between 46XY males with nonobstructive azoospermia and those with Klinefelter's syndrome. MATERIALS AND METHODS: We retrospectively reviewed the records of 140 men with azoospermia, including 100 46XY males with nonobstructive azoospermia and 40 with nonmosaic Klinefelter's syndrome, who underwent microdissection testicular sperm extraction. Serum follicle-stimulating hormone, luteinizing hormone and testosterone were evaluated before, and 1, 3, 6, 9, 12 and 18 months after surgery. RESULTS: In 46XY males with nonobstructive azoospermia serum follicle-stimulating hormone during 18 months of followup, and luteinizing hormone 1 and 3 months postoperatively were significantly increased vs baseline. No significant differences were observed in testosterone at any postoperative time point vs baseline. In men with Klinefelter's syndrome who underwent sperm extraction mean testosterone significantly decreased an average of 30% to 35% vs baseline when assessed 1, 3, 6, 9 and 12 months postoperatively. It returned to 75% of the preoperative level after 18 months. In Klinefelter's syndrome cases no significant differences were observed in follicle-stimulating hormone and luteinizing hormone at each postoperative time point. CONCLUSIONS: Hormonal followup after microdissection testicular sperm extraction is recommended, particularly in patients with Klinefelter's syndrome, to prevent the deleterious consequences of hypogonadism.

  Oct. 2009, The Journal of urology, 182(4) (4), 1495 - 9, English, International magazine

  Scientific journal


• The efficacy of adult orchidopexy as a treatment of male infertility: our experience of 20 cases.

  Koji Chiba, Tomomoto Ishikawa, Kohei Yamaguchi, Masato Fujisawa

  The objective of this study was to determine whether adult orchidopexy and testicular sperm extraction are effective or not as a treatment of infertility. In this study, we could not show the efficacy of orchidopexy as a treatment of infertility in adulthood, and testicular sperm extraction can be a useful treatment for adult patients with unilateral undescended testis.

  ELSEVIER SCIENCE INC, Oct. 2009, Fertility and sterility, 92(4) (4), 1337 - 1339, English, International magazine

  [Refereed]

  Scientific journal


• [Characteristics of prostatic cancer in men with a serum prostate-specific antigen level of < or =4.0 ng/ml].

  Yoshiharu Ono, Koji Chiba, Hirokazu Tanaka

  Fifteen out of 140 men (median age 67 years, range 62-75) had a serum prostate-specific antigen (PSA) level of < or = 4 ng/ml before radical prostatectomy which was performed without preoperative neoadjuvant hormonal therapy between 2001 January and 2004 September. Demographic and clinical data were analyzed. Pathological specimens were evaluated by routine hematoxylin and eosine staining and immunohistochemistry with anti-PSA antibody, for both pathological staging and grading, and for the presence of PSA production. Pathological data were compared between patients with PSA < or = 4 ng/ml and those with 4 < PSA < or = 10 ng/ml. Clinically insignificant cancer was defined as a cancer volume of < 0.5 ml and the Gleason score < or = 6. The median PSA level was 3.0 ng/ml (range 1.4-3.9). Thirteen tumors (87%) were pT2. One tumor had a Gleason score of 7 and 14 tumors had a final Gleason score of < or = 6. Nine (60%) tumors were clinically insignificant. Comparison of pathological variables, PSA < or = 4 ng/ml cancer had a significantly lower Gleason score (p = 0.0029), and a smaller cancer volume (p = 0.0451) than 4 < PSA < or = 10 ng/ml cancer. All tumors were stained strongly for PSA. During a median follow-up of 24 (9-36) months, no patient showed elevated PSA (PSA > or = 0.1 ng/ml). Most prostate cancers in men with a PSA level of < or = 4 ng/ml were pT2, and about half of them were clinically insignificant. All cancers produced PSA.

  Oct. 2005, Hinyokika kiyo. Acta urologica Japonica, 51(10) (10), 647 - 50, Japanese, Domestic magazine

  Scientific journal

• 【男性不妊症を知る】非閉塞性無精子症とその治療

  千葉 公嗣

  (有)科学評論社, Nov. 2020, 泌尿器科, 12(5) (5), 510 - 518, Japanese


• 無精子症に対する精索静脈瘤手術の治療成績

  千葉 公嗣, 佐藤 克哉, 大西 篤史, 賀來 泰大, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 307 - 307, Japanese


• 当院におけるOnco-TESEの検討

  大西 篤史, 佐藤 克哉, 賀來 泰大, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 338 - 338, Japanese


• 男性低ゴナドトロピン性性腺機能低下症へのゴナドトロピン補充療法中、補充中止可能と判断した3症例

  賀來 泰大, 佐藤 克哉, 大西 篤史, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 387 - 387, Japanese


• 特発性造精機能障害に対するレトロゾールの治療効果の検討

  岡田 桂輔, 佐藤 克哉, 大西 篤史, 賀來 泰大, 石田 貴樹, 福田 輝雄, 千葉 公嗣, 藤澤 正人

  (一社)日本生殖医学会, Nov. 2020, 日本生殖医学会雑誌, 65(4) (4), 390 - 390, Japanese


• 労働環境が原因で発症したと考えられる排尿障害の1例

  福田 輝雄, 千葉 公嗣, 古川 順也, 重村 克巳, 原田 健一, 石村 武志, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本排尿機能学会, Oct. 2020, 日本排尿機能学会誌, 31(1) (1), 215 - 215, Japanese


• 【性ホルモンと産生・依存性腫瘍の基礎と臨床】性ホルモン産生と作用機序 精巣におけるホルモン産生機構

  千葉 公嗣, 藤澤 正人

  ＜文献概要＞精巣の機能は視床下部下垂体性腺軸により制御され,精巣では最も主要なアンドロゲンであるテストステロンがLeydig細胞により産生されている。テストステロンは全身作用とともに精細管での精子形成にきわめて重要な働きをしており,精巣内テストステロンは血中に比較してきわめて高濃度に維持されている。若年時にはテストステロンの分泌には日内変動があるが,加齢とともにテストステロン分泌量と日内変動の振幅が低下する。

  (株)メディカルレビュー社, Jun. 2020, HORMONE FRONTIER IN GYNECOLOGY, 27(2) (2), 115 - 118, Japanese


• 遊離テストステロン別にみたLOH症候群の治療成績

  賀來 泰大, 大西 篤史, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2020, 日本生殖医学会雑誌, 65(1-2) (1-2), 120 - 120, Japanese


• 乳頭状腎細胞癌肺転移に対してイピリムマブ・ニボルマブ併用療法が奏功した1例

  京野 成紀, 原 琢人, 千葉 公嗣, 寺川 智章, 古川 順也, 原田 健一, 石村 武志, 重村 克己, 日向 信之, 中野 雄造, 藤澤 正人

  泌尿器科紀要刊行会, Mar. 2020, 泌尿器科紀要, 66(3) (3), 97 - 97, Japanese


• 男性低ゴナドトロピン性性腺機能低下症へのゴナドトロピン補充療法中、補充中止可能と判断した2症例

  賀來 泰大, 大西 篤史, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本内分泌学会, Feb. 2020, 日本内分泌学会雑誌, 95(4) (4), 1559 - 1559, Japanese


• 定型化した生体ドナー腎採取術を学ぶ 神戸大学での単孔式腹腔鏡下ドナー腎採取術

  石村 武志, 遠藤 貴人, 西岡 遵, 横山 直己, 小田 晃廉, 小川 悟史, 寺川 智章, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克巳, 藤澤 正人

  (一社)日本臨床腎移植学会, Feb. 2020, 日本臨床腎移植学会プログラム・抄録集, 53回, 123 - 123, Japanese


• 当院における小児がん患者の妊孕性温存について

  植村 優, 京野 由紀, 二野 菜々子, 高藤 哲, 山本 暢之, 西村 範行, 岡田 桂輔, 千葉 公嗣, 塩谷 雅英, 飯島 一誠

  (公社)日本小児科学会, Feb. 2020, 日本小児科学会雑誌, 124(2) (2), 293 - 293, Japanese


• 神経温存ロボット支援腹腔鏡下前立腺全摘除術後における性機能の検討

  中野 雄造, 寺川 智章, 千葉 公嗣, 古川 順也, 重村 克巳, 原田 健一, 石村 武志, 日向 信之, 藤澤 正人

  (一社)日本内視鏡外科学会, Dec. 2019, 日本内視鏡外科学会雑誌, 24(7) (7), MO093 - 3, Japanese


• 当院におけるアミノレブリン酸塩酸塩を併用した経尿道的膀胱腫瘍切除術の臨床検討

  大西 篤史, 寺川 智章, 千葉 公嗣, 古川 順也, 原田 健一, 重村 克巳, 日向 信之, 藤澤 正人

  (一社)日本内視鏡外科学会, Dec. 2019, 日本内視鏡外科学会雑誌, 24(7) (7), MO339 - 4, Japanese


• 当科における顕微鏡下内精静脈低位結紮術の検討

  岡田 桂輔, 大西 篤史, 賀來 泰大, 田中 幹人, 石田 貴樹, 福田 輝雄, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2019, 日本生殖医学会雑誌, 64(4) (4), 383 - 383, Japanese


• 精巣精子採取術後の合併症の検討

  千葉 公嗣, 賀來 泰大, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 江夏 徳寿, 塩谷 雅英, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2019, 日本生殖医学会雑誌, 64(4) (4), 386 - 386, Japanese


• 神戸大学におけるTSC-腎AMLに対するエベロリムスの治療成績

  原田 健一, 賀来 泰大, 千葉 公嗣, 中野 雄造, 藤澤 正人

  西日本泌尿器科学会, Oct. 2019, 西日本泌尿器科, 81(増刊) (増刊), 156 - 156, Japanese


• 当院における陰茎折症3例の検討

  石田 貴樹, 賀来 泰大, 田中 幹人, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 中野 雄造, 日向 信之, 藤澤 正人

  (一社)日本性機能学会, Aug. 2019, 日本性機能学会雑誌, 34(2) (2), 158 - 158, Japanese


• 低ゴナドトロピン性性腺機能低下症に対しゴナドトロピン補充療法を中断後、再開を余儀なくされた1例

  賀來 泰大, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Jul. 2019, 日本生殖医学会雑誌, 64(3) (3), 105 - 105, Japanese


• ラットセルトリ細胞のミラベグロンによる分子細胞生物学的影響の検討

  田中 幹人, 千葉 公嗣, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  泌尿器科紀要刊行会, Jun. 2019, 泌尿器科紀要, 65(6) (6), 252 - 252, Japanese


• 日本性機能学会員を対象とした陰圧式勃起補助具に関する実態調査

  辻村 晃, 千葉 公嗣, 福原 慎一郎, 菊地 栄次, 吉澤 剛, 巴 ひかる, 木村 和哲, 佐藤 嘉一, 永井 敦, 永尾 光一, 並木 幹夫

  (一社)日本性機能学会, Jun. 2019, 日本性機能学会雑誌, 34(1) (1), 47 - 47, Japanese


• 事例で学ぶ! 神戸大学における結節性硬化症(TSC)診断連携の実際

  原田 健一, 千葉 公嗣, 藤澤 正人

  (公社)日本皮膚科学会, May 2019, 日本皮膚科学会雑誌, 129(5) (5), 1136 - 1136, Japanese


• 低ゴナドトロピン性性腺機能低下症39例の臨床的検討

  千葉 公嗣, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2019, 日本泌尿器科学会総会, 107回, PP1 - 311, Japanese


• 男性不妊に対するクエン酸クロミフェンの治療効果の検討

  岡田 桂輔, 賀來 泰大, 田中 幹人, 石田 貴樹, 福田 輝男, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2019, 日本泌尿器科学会総会, 107回, PP1 - 312, Japanese


• 非閉塞性無精子症患者の染色体異常に関する臨床的検討

  松下 経, 千葉 公嗣, 岡田 桂輔, 福田 輝雄, 石田 貴樹, 田中 幹人, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2019, 日本泌尿器科学会総会, 107回, PP1 - 316, Japanese


• 当院での持続勃起症治療に関する検討

  田中 幹人, 松下 経, 賀來 泰大, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2019, 日本泌尿器科学会総会, 107回, PP3 - 210, Japanese


• 関節リウマチ、原発性胆汁性肝硬変を合併した腎移植患者に発症した腎移植後リンパ増殖性疾患の1例

  田代 裕己, 石村 武志, 岡田 桂輔, 千葉 公嗣, 古川 順也, 重村 克巳, 原田 健一, 松下 経, 日向 信之, 中野 雄造, 藤澤 正人

  泌尿器科紀要刊行会, Mar. 2019, 泌尿器科紀要, 65(3) (3), 93 - 93, Japanese


• 腎盂尿管移行部狭窄症に対するロボット支援腹腔鏡下腎盂形成術の初期経験

  寺川智章, 千葉公嗣, 古川順也, 原田健一, 石村武志, 重村克己, 山口雷蔵, 日向信之, 中野雄造, 藤澤正人

  2019, 日本泌尿器内視鏡学会(Web), 33rd


• 【内分泌症候群(第3版)-その他の内分泌疾患を含めて-】 男性性機能 性腺機能低下症 Laurence-Moon-Biedl症候群

  Chiba Koji, 藤澤正人

  (株)日本臨床社, Jan. 2019, 別冊日本臨床 領域別症候群シリーズ 内分泌症候群, 別冊(内分泌症候群III) (内分泌症候群III), 29 - 31, Japanese

  [Invited]

  Introduction commerce magazine


• 膀胱ヘルニアを合併した前立腺癌に対しロボット支援下前立腺全摘除術を施行した1例

  寺川 智章, 千葉 公嗣, 原田 健一, 重村 克己, 石村 武志, 日向 信之, 藤澤 正人

  (一社)日本内視鏡外科学会, Dec. 2018, 日本内視鏡外科学会雑誌, 23(7) (7), DP137 - 8, Japanese


• 膀胱ヘルニアを合併した前立腺癌に対しロボット支援下前立腺全摘除術を施行した1例

  寺川 智章, 千葉 公嗣, 原田 健一, 重村 克己, 石村 武志, 日向 信之, 藤澤 正人

  (一社)日本内視鏡外科学会, Dec. 2018, 日本内視鏡外科学会雑誌, 23(7) (7), DP137 - 8, Japanese


• 【男性不妊アップデート-ARTをする前に知っておきたい基礎知識】薬物療法 低ゴナドトロピン性性腺機能低下症とその治療

  Chiba Koji, 藤澤正人

  ＜文献概要＞●MHHは頻度の高い疾患ではないが,無精子症症例でも薬物療法のみで自然妊娠まで期待できる,数少ない男性不妊疾患の1つである.●遺伝子異常などが関与する先天性MHHと,脳外科手術などが関与する後天性MHHがある.●妊孕性を目的とした治療の中心はhCG製剤とrecombinant human FSH(r-hFSH)製剤の投与であり,在宅自己注射が保険診療上承認されている.

  (株)医学書院, Nov. 2018, 臨床婦人科産科, 72(11) (11), 1087 - 1092, Japanese

  [Invited]

  Introduction scientific journal


• 当院における尿路上皮癌に対するペムブロリズマブの初期使用経験

  安野恭平, 古川順也, 原琢人, 鈴木光太郎, 寺川智章, 千葉公嗣, 原田健一, 松下経, 石村武志, 重村克巳, 日向信之, 中野雄造, 藤澤正人

  西日本泌尿器科学会, 20 Oct. 2018, 西日本泌尿器科, 80(増刊) (増刊), 212 - 212, Japanese


• 男性不妊症の診断と治療

  千葉 公嗣

  西日本泌尿器科学会, Oct. 2018, 西日本泌尿器科, 80(増刊) (増刊), np6 - np6, Japanese


• 当院における尿路上皮癌に対するペムブロリズマブの初期使用経験

  安野 恭平, 古川 順也, 原 琢人, 鈴木 光太郎, 寺川 智章, 千葉 公嗣, 原田 健一, 松下 経, 石村 武志, 重村 克巳, 日向 信之, 中野 雄造, 藤澤 正人

  西日本泌尿器科学会, Oct. 2018, 西日本泌尿器科, 80(増刊) (増刊), 212 - 212, Japanese


• HoLEPにおける術前5α還元酵素阻害剤内服の手術成績に与える影響についての検討

  重村 克巳, 岡田 桂輔, 千葉 公嗣, 中野 雄造, 藤澤 正人

  (一社)日本排尿機能学会, Sep. 2018, 日本排尿機能学会誌, 29(1) (1), 207 - 207, Japanese


• 低ゴナドトロピン性性腺機能低下症39例の臨床的検討

  千葉 公嗣, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 289 - 289, Japanese


• 摂食障害による男性低ゴナドトロピン性性腺機能低下症の1例

  石田 貴樹, 角井 健太, 田中 幹人, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 383 - 383, Japanese


• 射精障害に対するアモキサピンおよびイミプラミンの有用性

  松下 経, 千葉 公嗣, 岡田 桂輔, 福田 輝雄, 角井 健太, 石田 貴樹, 田中 幹人, 藤澤 正人

  (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 383 - 383, Japanese


• 男性不妊に対するクエン酸クロミフェンの効果

  岡田 桂輔, 賀來 泰大, 田中 幹人, 石田 貴樹, 福田 輝雄, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Aug. 2018, 日本生殖医学会雑誌, 63(3) (3), 423 - 423, Japanese


• 日本性機能学会員を対象とした陰茎プロステーシスに関する実態調査

  辻村 晃, 福原 慎一郎, 千葉 公嗣, 菊地 栄次, 吉澤 剛, 巴 ひかる, 木村 和哲, 佐藤 嘉一, 永井 敦, 永尾 光一, 並木 幹夫

  (一社)日本性機能学会, Aug. 2018, 日本性機能学会雑誌, 33(2) (2), 210 - 210, Japanese


• 当院での持続勃起症治療に関する検討

  田中 幹人, 松下 経, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 藤澤 正人

  (一社)日本性機能学会, Aug. 2018, 日本性機能学会雑誌, 33(2) (2), 218 - 218, Japanese


• 当科における陰茎折症2例の検討

  岡田 桂輔, 小田 晃廉, 千葉 公嗣, 松下 経, 古川 順也, 中野 雄造, 藤澤 正人

  (一社)日本性機能学会, Aug. 2018, 日本性機能学会雑誌, 33(2) (2), 224 - 224, Japanese


• LOH症候群患者に対する男性ホルモン補充療法の性機能への影響と治療満足度との関連

  福田 輝雄, 田中 幹人, 石田 貴樹, 岡田 桂輔, 千葉 公嗣, 松下 経, 中野 雄造, 藤澤 正人

  (一社)日本性機能学会, Aug. 2018, 日本性機能学会雑誌, 33(2) (2), 230 - 230, Japanese


• 男性不妊症の診断と治療

  千葉 公嗣

  (一社)日本泌尿器科学会, Jul. 2018, 日本泌尿器科学会雑誌, 109(3) (3), np6 - np6, Japanese


• 術前診断で副腎悪性腫瘍が疑われた副腎Black Adenomaの1例

  田代裕己, 千葉公嗣, 岡田桂輔, 古川順也, 重村克巳, 原田健一, 石村武志, 松下経, 日向信之, 中野雄造, 藤澤正人

  泌尿器科紀要刊行会, Jul. 2018, 泌尿器科紀要, 64(7) (7), 314 - 314, Japanese


• 【生殖医療のいま】 不妊治療 男性不妊の原因

  Chiba Koji, 藤澤正人

  ＜ポイント＞●不妊症の原因の約半数で男性因子が関与するとされ、男性因子の有無についても積極的に診察することが重要である。●男性不妊症は精子形成障害、精路通過障害、射精障害に大別できるが、性機能障害により十分な性交渉が行われていないこともある。●男性不妊症をきっかけに染色体異常や精巣腫瘍が発見されることがある。●男性不妊症患者において、触知可能な精索静脈瘤に対する外科的治療の有用性が認められている。●鼠径ヘルニアの手術後に閉塞性無精子症を呈することがある。(著者抄録)

  (株)新興医学出版社, Jul. 2018, Modern Physician, 38(7) (7), 730 - 732, Japanese

  [Invited]

  Introduction scientific journal


• 当院における副腎褐色細胞腫に対する腹腔鏡下手術の臨床的検討

  白石祐介, 千葉公嗣, 岡田桂輔, 古川順也, 重村克己, 原田健一, 石村武志, 松下経, 日向信之, 中野雄造, 藤澤正人

  日本内分泌外科学会・日本甲状腺外科学会, May 2018, 日本泌尿器科学会総会(Web), 35(Suppl.1) (Suppl.1), S138 - S138, Japanese


• 【男性不妊症と免疫】精巣捻転症

  Chiba Koji, 藤澤正人

  May 2018, 実践臨床生殖免疫学, 247 - 251, Japanese

  [Invited]

  Introduction commerce magazine


• 過度なダイエットによりED、射精障害を認めた1例

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 中野 雄造, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2018, 日本生殖医学会雑誌, 63(1-2) (1-2), 119 - 119, Japanese


• 性分化・性成熟疾患における新しい展開 神戸大学における低ゴナドトロピン性性腺機能低下症の治療経験

  千葉 公嗣, 藤澤 正人

  (一社)日本内分泌学会, Apr. 2018, 日本内分泌学会雑誌, 94(1) (1), 185 - 185, Japanese


• 顕微鏡下精巣精子採取術(micro TESE)の治療成績

  千葉 公嗣, 岡田 桂輔, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 松下 経, 塩谷 雅英, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会, 106回, PP3 - 112, Japanese


• SUMO化阻害によるセルトリ細胞の核受容体やsignaling pathwayへの影響

  岡田 桂輔, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝男, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会, 106回, PP3 - 229, Japanese


• 前立腺肥大を有さないLOH症候群患者の血清テストステロン値と夜間頻尿との関係

  角井 健太, 千葉 公嗣, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 径, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会, 106回, PP3 - 374, Japanese


• 射精障害に対するアモキサピンおよびイミプラミンの有用性

  松下 経, 千葉 公嗣, 岡田 桂輔, 福田 輝雄, 角井 健太, 石田 貴樹, 田中 幹人, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会, 106回, PP3 - 379, Japanese


• 当院における副腎褐色細胞腫に対する腹腔鏡下手術の臨床的検討

  白石 祐介, 千葉 公嗣, 岡田 桂輔, 古川 順也, 重村 克己, 原田 健一, 石村 武志, 松下 経, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会, 106回, PP2 - 111, Japanese


• ロボット支援腎部分切除術におけるTrifecta達成に関する要因の検討

  古川順也, 日向信之, 小川悟史, 岡田圭輔, 寺川智章, 千葉公嗣, 重村克巳, 原田健一, 松下経, 石村武志, 中野雄造, 藤澤正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2018, 日本泌尿器科学会総会(Web), 106回, OP - 345, Japanese


• Zinner症候群が疑われた無精子症の1例

  岩下 和真, 田中 宇多留, 末永 裕子, 高橋 哲, 杉本 幸司, 杉村 和朗, 江夏 徳寿, 千葉 公嗣

  (公社)日本医学放射線学会, Feb. 2018, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 30 - 30, Japanese


• 当院における副腎腫瘍マネージメントにおける術後多科合同カンファレンスについて

  重村克巳, 重村克巳, 寺川智章, 千葉公嗣, 古川順也, 原田健一, 日向信之, 福岡秀規, 高橋裕, 中野雄造, 藤澤正人

  2018, Japanese Journal of Endourology, 31(3 (Web)) (3 (Web))


• Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor.

  Mikito Tanaka, Noritoshi Enatsu, Koji Chiba, Masato Fujisawa

  Cases: Testicular adrenal rest tumor (TART) is one of the possible causes of male infertility, accompanied by congenital adrenal hyperplasia (CAH). Here are reported two cases of TARTs that were referred to Kobe City Medical Center West Hospital for the treatment of infertility and testicular tumors. Outcome: In one case, the semen analysis was improved from oligoasthenozoospermia to normozoospermia after taking oral glucocorticoid supplementation. The other case of original azoospermia showed that sperm had ejaculated into the semen after taking oral glucocorticoid supplementation. Conclusion: Although the prevalence of TARTs in male infertility is very rare, it is important to know how to approach this disease, considering the curable pathology of spermatogenesis and tumors resembling an appearance to germ cell tumors.

  Jan. 2018, Reproductive medicine and biology, 17(1) (1), 93 - 97, English, Domestic magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 持続勃起症の9例

  松下 経, 千葉 公嗣, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, 藤澤 正人

  (一社)日本性機能学会, Dec. 2017, 日本性機能学会雑誌, 32(3) (3), 286 - 286, Japanese


• 副腎褐色細胞腫に対する腹腔鏡下手術の臨床的検討

  千葉 公嗣, 重村 克巳, 原田 健一, 石村 武志, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本内視鏡外科学会, Dec. 2017, 日本内視鏡外科学会雑誌, 22(7) (7), EP217 - 05, Japanese


• 術前前立腺体積、摘出前立腺重量とHoLEP術後の排尿困難改善と相関についての検討

  重村 克巳, 千葉 公嗣, 山道 深, 山田 裕二, 田中 宏和, 岡 康彦, 山下 真寿男, 藤澤 正人

  (一社)日本泌尿器内視鏡学会, Nov. 2017, Japanese Journal of Endourology, 30(3) (3), 168 - 168, Japanese


• クラインフェルター症候群以外の染色体異常を有する非閉塞性無精子症患者の臨床的検討

  角井 健太, 千葉 公嗣, 田中 幹人, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2017, 日本生殖医学会雑誌, 62(4) (4), 445 - 445, Japanese


• SUMO化阻害によるセルトリ細胞のsignaling pathwayへの影響

  岡田 桂輔, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2017, 日本生殖医学会雑誌, 62(4) (4), 457 - 457, Japanese


• 非閉塞性無精子症に対してサルベージ内分泌療法を施行した2例

  千葉 公嗣, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, 江夏 徳寿, 松下 経, 塩谷 雅英, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2017, 日本生殖医学会雑誌, 62(4) (4), 508 - 508, Japanese


• 神戸大学における結節性硬化症に伴う腎血管筋脂肪腫に対するエベロリムスの治療成績

  原田健一, 坂本茉莉子, 板東由加里, 鈴木光太郎, 原琢人, 桃園宏之, 千葉公嗣, 古川順也, 重村克巳, 石村武志, 日向信之, 中野雄造, 藤澤正人

  西日本泌尿器科学会, Oct. 2017, 西日本泌尿器科, 79(増刊) (増刊), 156 - 156, Japanese


• 神戸大学におけるロボット支援根治的膀胱全摘除術の初期経験

  日向信之, 寺川智章, 千葉公嗣, 松下経, 古川順也, 原田健一, 石村武志, 中野雄造, 藤澤正人

  日本外科系連合学会, Oct. 2017, 日本外科系連合学会誌, 42(5) (5), 897 - 897, Japanese


• A Case of Coexistence of Aldosterone-Producing Adenoma and Pheochromocytoma in an Unilateral Adrenal Gland

  前田光毅, 千葉公嗣, 古川順也, 重村克巳, 原田健一, 石村武志, 日向信之, 中野雄造, 藤澤正人

  42歳女性。38歳時に高血圧を指摘されたが放置。42歳で子宮腺筋症を指摘、画像検査で左副腎に2つの独立した腺腫を指摘された。アルドステロンレニン比の上昇、立位フロセミド負荷試験陽性、アドステロールシンチ陽性から、頭側の腺腫はアルドステロン産生腺腫(APA)、塩酸蓄尿検査でカテコラミンの上昇、MIBGシンチ陽性から、尾側の腺腫は褐色細胞腫(PC)と診断し、腹腔鏡下左副腎摘除術を施行。病理組織はAPAとPCの合併であった。(著者抄録)

  医学図書出版(株), Oct. 2017, 泌尿器外科, 30(10) (10), 1589 - 1592, Japanese


• 神戸大学における結節性硬化症に伴う腎血管筋脂肪腫に対するエベロリムスの治療成績

  原田 健一, 坂本 茉莉子, 板東 由加里, 鈴木 光太郎, 原 琢人, 桃園 宏之, 千葉 公嗣, 古川 順也, 重村 克巳, 石村 武志, 日向 信之, 中野 雄造, 藤澤 正人

  西日本泌尿器科学会, Oct. 2017, 西日本泌尿器科, 79(増刊) (増刊), 156 - 156, Japanese


• 神戸大学におけるロボット支援根治的膀胱全摘除術の初期経験

  日向 信之, 寺川 智章, 千葉 公嗣, 松下 経, 古川 順也, 原田 健一, 石村 武志, 中野 雄造, 藤澤 正人

  日本外科系連合学会, Oct. 2017, 日本外科系連合学会誌, 42(5) (5), 897 - 897, Japanese


• HoLEP術後の排尿困難改善に術前前立腺体積、摘出前立腺重量は関連するかの検討

  重村 克巳, 山道 深, 千葉 公嗣, 山田 裕二, 田中 宏和, 岡 康彦, 山下 真寿男, 藤澤 正人

  (一社)日本排尿機能学会, Sep. 2017, 日本排尿機能学会誌, 28(1) (1), 286 - 286, Japanese


• LOH症候群患者に対する男性ホルモン補充療法の性機能への影響

  福田 輝雄, 田中 幹人, 石田 貴樹, 角井 健太, 千葉 公嗣, 松下 経, 中野 雄造, 藤澤 正人

  (一社)日本性機能学会, Aug. 2017, 日本性機能学会雑誌, 32(2) (2), 204 - 204, Japanese


• 同一副腎にアルドステロン産生腺腫と褐色細胞腫を認めた1例

  前田光毅, 千葉公嗣, 古川順也, 原田健一, 日向信之, 石村武志, 中野雄造, 藤沢正人

  泌尿器科紀要刊行会, Aug. 2017, 泌尿器科紀要, 63(8) (8), 341 - 341, Japanese


• 造精機能障害および精巣Adrenal rest tumorを伴った先天性副腎皮質過形成の2例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  泌尿器科紀要刊行会, Jul. 2017, 泌尿器科紀要, 63(7) (7), 290 - 291, Japanese


• Leydig細胞過形成を伴ったクラインフェルター症候群の1例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2017, 日本生殖医学会雑誌, 62(1-2) (1-2), 112 - 112, Japanese


• 癌治療前の凍結保存精子の使用状況

  千葉 公嗣, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 江夏 徳寿, 松下 経, 塩谷 雅英, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, OP01 - 6, Japanese


• 精子運動解析装置SMASを用いた精子機能評価と体外受精における受精率の関係

  江夏 徳寿, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 千葉 公嗣, 松下 経, 藤澤 正人, 塩谷 雅英

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, OP02 - 1, Japanese


• HoLEPの術者経験数別での手術成績・合併症に関する多施設検討

  重村 克巳, 千葉 公嗣, 江夏 徳寿, 福田 輝雄, 安福 富彦, 山道 深, 山田 裕二, 岡 泰彦, 田中 宏和, 山下 真寿男, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, OP75 - 2, Japanese


• 持続勃起症の9例

  松下 経, 千葉 公嗣, 江夏 徳寿, 福田 輝雄, 角井 健太, 石田 貴樹, 田中 幹人, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, PP25 - 07, Japanese


• 主訴が疼痛である精索静脈瘤に対する手術成績の検討

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, PP57 - 06, Japanese


• LOH症候群患者に対するテストステロン補充療法が精神症状に及ぼす影響についての検討

  角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, PP92 - 01, Japanese


• LOH症候群患者に対する男性ホルモン補充療法の長期成績

  福田 輝雄, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, 千葉 公嗣, 松下 経, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会, 105回, PP92 - 02, Japanese


• PROSPECTIVE ASSESSMENT OF PSYCHOLOGICAL SYMPTOMS IN MEN WITH LATE-ONSET HYPOGONADISM WHO RECEIVED TESTOSTERONE REPLACEMENT THERAPY

  Kenta Sumii, Mikito Tanaka, Takaki Ishida, Noritoshi Enatsu, Koji Chiba, Kei Matsushita, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2017, JOURNAL OF UROLOGY, 197(4) (4), E1160 - E1160, English

  Summary international conference


• 神経温存ロボット支援根治的前立腺全摘除術後の摘出床へのHA‐CM貼付が術後尿禁制に及ぼす影響

  日向信之, 板東由加里, 鈴木光太郎, 桃園宏之, 今井聡士, 宮崎彰, 寺川智章, 千葉公嗣, 古川順也, 原田健一, 石村武志, 中野雄造, 藤澤正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2017, 日本泌尿器科学会総会(Web), 105回, PP95 - 10, Japanese


• LOH (late-onset hypogonadism) syndrome.

  Koji Chiba, Masato Fujisawa

  Testosterone deficiency has recently drawn wide attention due to the high prevalence of hypo-gonadal symptoms in the aging male population. A number of studies have reported the beneficial effects of testosterone replacement therapy for men with late-onset hypogonadism (LOH) syndrome. Based on the study evaluating the age distribution of serum testosterone concentration, serum free testosterone less than 8.5 pg/mL is considered as a good indica- tion for testosterone replacement therapy among the Japanese population. However, at present, testosterone enanthate is the only drug that is covered by health insurance in Japan. Further studies are needed to establish more suitable treatment in men with LOH syndrome among Japanese population.

  (株)日本臨床社, Apr. 2017, Nihon rinsho. Japanese journal of clinical medicine, 75(4) (4), 588 - 592, Japanese, Domestic magazine

  [Invited]


• 【不妊と薬 エキスパートが教える薬物治療の"知識"と"ノウハウ"】男性不妊における各種治療薬の考え方・使い方と患者説明のポイント 非ホルモン療法

  千葉 公嗣, 藤澤 正人

  ＜Key Points＞非内分泌療法は男性不妊症の日常臨床において用いられる頻度は高いが、エビデンスレベルの高い薬剤は少ない。漢方製剤が精液所見の改善に一定の効果があり、広く用いられている。ビタミンB12、ビタミンE、ビタミンCが漢方製剤に併用されて用いられることもある。コエンザイムQ10やカルニチンといった抗酸化力をもつサプリメントも用いられている。漫然と治療を長引かせるべきではなく、適切なタイミングでの生殖補助医療の実施の判断を考えておくことが重要である。決して薬物療法のみに頼らず、精子形成に悪影響を及ぼす生活習慣があれば、適切な指導を行うことも重要である。(著者抄録)

  (株)南山堂, Feb. 2017, 薬局, 68(2) (2), 297 - 300, Japanese


• 男性不妊における各種治療薬の考え方、使い方と患者説明のポイント非内分泌療法

  Chiba Koji, 藤澤正人

  Feb. 2017, 薬局, 68(2) (2), 89 - 92, Japanese

  [Invited]

  Introduction scientific journal


• ヒトiSP細胞誘導Leydig細胞の作製

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤沢 正人, 青井 貴之

  (一社)日本内分泌学会, Jan. 2017, 日本内分泌学会雑誌, 92(3) (3), 824 - 824, Japanese


• ラット精巣虚血-再還流障害に対するウロコルチンの生殖細胞保護作用についての検討

  角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  日本生殖免疫学会, Nov. 2016, Reproductive Immunology and Biology, 31(1-2) (1-2), 142 - 142, Japanese


• The role of urocortin in the apoptosis of germ cells after experimental testicular ischemia-reperfusion in the rat

  Kenta Sumii, Mikito Tanaka, Takaki Ishida, Teruo Fukuda, Noritoshi Enatsu, Koji Chiba, Kei Matsushita, Masato Fujisawa

  ELSEVIER IRELAND LTD, Nov. 2016, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 118, 139 - 139, English

  Summary international conference


• 後腹膜アプローチによるロボット支援腎部分切除術の成績

  古川 順也, 寺川 智章, 千葉 公嗣, 松下 経, 重村 克巳, 原田 健一, 石村 武志, 日向 信之, 中野 雄造, 藤澤 正人

  (一社)日本泌尿器内視鏡学会, Nov. 2016, Japanese Journal of Endourology, 29(3) (3), 243 - 243, Japanese


• 当科における精索静脈瘤手術の臨床的検討

  千葉 公嗣, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 江夏 徳寿, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 352 - 352, Japanese


• デュタステリドが尿路生殖器系に与える影響とホルモンレセプターの発現変化

  江夏 徳寿, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 千葉 公嗣, 松下 経

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 358 - 358, Japanese


• 精巣虚血-再還流障害モデルラットを用いた抗アポトーシス蛋白としてのウロコルチンの特性解析

  角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 447 - 447, Japanese


• 造精機能障害および精巣adrenal rest tumorを伴った先天性副腎皮質過形成の2例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 448 - 448, Japanese


• 当科における低ゴナドトロピン性性腺機能低下症62例の臨床的検討

  福田 輝雄, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 451 - 451, Japanese


• 乳房腫大を契機に発見された軽症型アンドロゲン不応症の一例

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 451 - 451, Japanese


• 男性不妊症患者における非内分泌薬物療法の有用性の検討

  松下 経, 千葉 公嗣, 江夏 徳寿, 福田 輝雄, 角井 健太, 石田 貴樹, 田中 幹人, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 453 - 453, Japanese


• 我が国における男性不妊に対する検査・治療に関する調査研究 泌尿器科領域生殖医療専門医へのアンケート調査より(その1) 男性不妊患者数ならびに疾患分類の調査結果

  湯村 寧, 岩本 晃明, 辻村 晃, 今本 敬, 梅本 幸裕, 小林 秀行, 白石 晃司, 慎 武, 谷口 久哲, 千葉 公嗣, 宮川 康

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 492 - 492, Japanese


• 我が国における男性不妊に対する検査・治療に関する調査研究 泌尿器科領域生殖医療専門医へのアンケート調査より(その2) 男性不妊に対する検査・治療についての調査結果

  湯村 寧, 岩本 晃明, 辻村 晃, 今本 敬, 梅本 幸裕, 小林 秀行, 白石 晃司, 慎 武, 谷口 久哲, 千葉 公嗣, 宮川 康

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 492 - 492, Japanese


• 我が国における男性不妊に対する検査・治療に関する調査研究 泌尿器科領域生産医療専門医へのアンケート調査より(その3) 婦人科との連携に関する調査について

  湯村 寧, 岩本 晃明, 辻村 晃, 今本 敬, 梅本 幸裕, 小林 秀行, 白石 晃司, 慎 武, 谷口 久哲, 千葉 公嗣, 宮川 康

  (一社)日本生殖医学会, Oct. 2016, 日本生殖医学会雑誌, 61(4) (4), 492 - 492, Japanese


• 男性低ゴナドトロピン性性腺機能低下症の基礎と臨床

  江夏 徳寿, 千葉 公嗣, 藤澤 正人

  日本生殖内分泌学会, Aug. 2016, 日本生殖内分泌学会雑誌, 21, 17 - 22, Japanese


• デュタステリドが尿路生殖器系に与える影響とホルモンレセプターの発現変化

  江夏 徳寿, 石田 貴樹, 角井 健太, 福田 輝雄, 千葉 公嗣, 松下 経, 藤澤 正人

  (一社)日本性機能学会, Aug. 2016, 日本性機能学会雑誌, 31(2) (2), 144 - 144, Japanese


• Clinical Outcomes of Varicocele Repair in Infertile Men: A Review.

  Koji Chiba, Masato Fujisawa

  Varicoceles are a major cause of impaired spermatogenesis and the most common correctable cause of male infertility. They are found in approximately 40% of men with primary infertility and 80% of men with secondary infertility, although they also occur in 12% of men with normal semen parameters. The presence of a varicocele does not always affect spermatogenesis, as it has been reported that only 20% of men with documented varicoceles suffer fertility problems. However, varicocele repair appears to have beneficial effects in men with impaired semen parameters and palpable varicoceles. Currently, the main procedures employed for varicocele repair are microsurgical subinguinal or inguinal varicocelectomy, laparoscopic varicocelectomy, and radiological percutaneous embolization. Microsurgical varicocelectomy appears to be the optimal treatment in most cases, whereas the other procedures are useful only in specific cases. After treatment, it typically takes 3 to 6 months for patients' semen parameters to improve; thus, other therapies, including assisted reproductive technology, should be considered if infertility persists after this interval, especially in older couples. Controversies still remain regarding how varicoceles in certain subgroups, such as adolescents or men with azoospermia, should be treated. Due to their relatively high prevalence rate among the general population, varicoceles can occur concomitantly with other conditions that cause impaired spermatogenesis. Further studies are necessary in order to identify the patients who are most likely to benefit from treatment. In this review, we sought to summarize the issues currently associated with varicocele treatment in infertile men.

  KOREAN SOC SEXUAL MEDICINE & ANDROLOGY, Aug. 2016, The world journal of men's health, 34(2) (2), 101 - 9, English, International magazine

  [Refereed]


• The development of surgical sperm extraction and new challenges to improve the outcome.

  Noritoshi Enatsu, Koji Chiba, Masato Fujisawa

  Surgical sperm extraction with intracytoplasmic sperm injection has become widespread worldwide and is regarded as the sole option for patients with azoospermia. However, the sperm retrieval rate remains unsatisfactorily low, particularly for men with non-obstructive azoospermia (NOA). Therefore, the technical challenges associated with improving the sperm retrieval rate for men with NOA are being addressed. The most successful method developed to date is microdissection testicular sperm extraction (micro-TESE), which is rapidly becoming recognized as a useful technique due to its relatively high sperm retrieval rate and low complication rate. However, even with micro-TESE, the sperm retrieval rate for men with NOA remains at 30-60 %, with an even lower birth rate. The technical challenges associated with improving the outcomes of surgical sperm extraction are being approached through the use of ultrasound and optimal surgical devices such as narrow band imaging, multiphoton microscopy, and optical coherent tomography. In addition to the difficulties related to searching for sperm, medical treatments that induce spermatogenesis remain controversial. For example, varicocele repair prior to surgical sperm extraction and hormonal therapy before and after TESE have been extensively examined. We herein briefly summarized the development process in surgical sperm extraction up to the present and technical challenges to improve the outcomes of surgical sperm extraction.

  John Wiley and Sons Ltd, Jul. 2016, Reproductive medicine and biology, 15(3) (3), 137 - 144, English, Domestic magazine

  [Refereed]


• Management of non-obstructive azoospermia.

  Koji Chiba, Noritoshi Enatsu, Masato Fujisawa

  Non-obstructive azoospermia (NOA) is defined as no sperm in the ejaculate due to failure of spermatogenesis and is the most severe form of male infertility. The etiology of NOA is either intrinsic testicular impairment or inadequate gonadotropin production. Chromosomal or genetic abnormalities should be evaluated because there is a relatively high incidence compared with the normal population. Although rare, NOA due to inadequate gonadotropin production is a condition in which fertility can be improved by medical treatment. In contrast, there is no treatment that can restore spermatogenesis in the majority of NOA patients. Consequently, testicular extraction of sperm under an operating microscope (micro-TESE) has been the first-line treatment for these patients. Other treatment options include varicocelectomy for NOA patients with a palpable varicocele and orchidopexy if undescended testes are diagnosed after adulthood, although management of these patients remains controversial. Advances in retrieving spermatozoa more efficiently by micro-TESE have been made during the past decade. In addition, recent advances in biotechnology have raised the possibility of using germ cells produced from stem cells in the future. This review presents current knowledge about the etiology, diagnosis, and treatment of NOA.

  John Wiley and Sons Ltd, Jul. 2016, Reproductive medicine and biology, 15(3) (3), 165 - 173, English, Domestic magazine

  [Refereed]


• 男性不妊と精巣機能

  Chiba Koji, 藤澤正人

  (公社)日本医師会, May 2016, 日本医師会雑誌, 145(2) (2), 273 - 276, Japanese

  [Invited]

  Introduction scientific journal


• Recent advances in the genetics of testicular failure

  Seung-Hun Song, Koji Chiba, Ranjith Ramasamy, Dolores J. Lamb

  Infertility affects approximately 15% of couples, and male factor is responsible for 30%-50% of all infertility. The most severe form of male infertility is testicular failure, and the typical phenotype of testicular failure is severely impaired spermatogenesis resulting in azoospermia or severe oligozoospermia. Although the etiology of testicular failure remains poorly understood, genetic factor typically is an underlying cause. Modern assisted reproductive techniques have revolutionized the treatment of male factor infertility, allowing biological fatherhood to be achieved by many men who would otherwise have been unable to become father to their children through natural conception. Therefore, identifying genetic abnormalities in male is critical because of the potential risk of transmission of genetic abnormalities to the offspring. Recently, along with other intense researches ongoing, whole-genome approaches have been used increasingly in the genetic studies of male infertility. In this review, we focus on the genetics of testicular failure and provide an update on the advances in the study of genetics of male infertility.

  MEDKNOW PUBLICATIONS & MEDIA PVT LTD, May 2016, ASIAN JOURNAL OF ANDROLOGY, 18(3) (3), 350 - 355, English

  [Refereed]

  Book review


• ラット精巣虚血-再還流障害に対するウロコルチンの生殖細胞保護作用についての検討

  角井 健太, 千葉 公嗣, 福田 輝雄, 江夏 徳寿, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2016, 日本生殖医学会雑誌, 61(1-2) (1-2), 95 - 95, Japanese


• ラット精巣虚血-再還流障害に対するウロコルチンの生殖細胞保護作用についての検討

  角井 健太, 江夏 徳寿, 福田 輝雄, 千葉 公嗣, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 121, Japanese


• 非閉塞無精子症患者におけるMSH5過メチル化の検討

  千葉 公嗣, Ridgeway Alex, Lamb Dolores, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 123, Japanese


• 当科における低ゴナドトロピン性性腺機能低下症50例の臨床的検討

  福田 輝雄, 角井 健太, 江夏 徳寿, 千葉 公嗣, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 142, Japanese


• 男性血液透析患者の性機能に関する検討

  松下 経, 吉矢 邦彦, 長富 俊孝, 角井 健太, 福田 輝雄, 江夏 徳寿, 千葉 公嗣, 三宅 秀明, 原 章二, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 144, Japanese


• 男性不妊症患者における非内分泌薬物療法の有用性の検討

  江夏 徳寿, 角井 健太, 福田 輝雄, 千葉 公嗣, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, OP - 102, Japanese


• THE COMPARISON OF ERECTILE FUNCTION BETWEEN RADICAL NEPHRECTOMY GROUP AND PARTIAL NEPHRECTOMY GROUP.

  Kei Matsushita, Hideaki Miyake, Takaki Ishida, Kenta Sumii, Teruo Fukuda, Noritoshi Enatsu, Koji Chiba, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2016, JOURNAL OF UROLOGY, 195(4) (4), E630 - E630, English

  Summary international conference


• 腎門部腫瘍に対するロボット支援腎部分切除術の成績

  古川 順也, 西川 昌友, 寺川 智章, 千葉 公嗣, 重村 克巳, 松下 経, 日向 信之, 原田 健一, 石村 武志, 村蒔 基次, 三宅 秀明, 田中 一志, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 243, Japanese


• 腎門部腫瘍に対するロボット支援腎部分切除術の成績

  古川 順也, 西川 昌友, 寺川 智章, 千葉 公嗣, 重村 克巳, 松下 経, 日向 信之, 原田 健一, 石村 武志, 村蒔 基次, 三宅 秀明, 田中 一志, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2016, 日本泌尿器科学会総会, 104回, PP2 - 243, Japanese


• The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives

  Koji Chiba, Ranjith Ramasamy, Dolores J. Lamb, Larry I. Lipshultz

  A varicocele is defined as the abnormal dilation of the internal testicular vein and pampiniform venus plexus within the spermatic cord. If a semen analysis is not obtained from the adolescent male, in the absence of other symptoms, the main clinical indication used by many urologists to recommend repair is testicular atrophy. The varicocele may result in testicular damage in some males causing testicular atrophy with impaired sperm production and decreased Leydig cell function, while in other males the varicocele may seemingly cause no ill effects. In adult men, varicoceles are frequently present and surgically correctable, yet the measurable benefits of surgical repair are slight according to a Cochrane review. While occurring more commonly in infertile men than fertile men, only 20% of men with a documented varicocele will suffer from fertility problems. Most varicoceles found in adolescents are detected during a routine medical examination, and it is difficult to predict which adolescent presenting with a varicocele will ultimately show diminished testicular function in adolescence or adulthood. As in adults, the mainstay of treatment for varicocele in adolescents is surgical correction. However, unlike an adult varicocelectomy (the microsurgical approach is the most common), treatment for an adolescent varicocele is more often laparoscopic. Nevertheless, the goals of treatment are the same in the adolescent and adult patients. Controversy remains as to which patients to treat, when to initiate the treatment, and what type of treatment is the best. This review will present the current understanding of the etiology, diagnosis and treatment of the adolescent varicocele.

  MEDKNOW PUBLICATIONS & MEDIA PVT LTD, Mar. 2016, ASIAN JOURNAL OF ANDROLOGY, 18(2) (2), 276 - 281, English

  [Refereed]

  Book review


• Predictive factors of successful sperm retrieval on microdissection testicular sperm extraction in Japanese men.

  Noritoshi Enatsu, Hideaki Miyake, Koji Chiba, Masato Fujisawa

  Purpose: To evaluate retrospectively the outcomes of microdissection testicular sperm extraction (micro-TESE) in men with nonobstructive azoospermia (NOA) and to identify the parameters predicting successful sperm retrieval in this cohort of patients. Methods: After excluding patients with normal testicular volume and serum follicle-stimulating hormone (FSH) level who received conventional TESE, this study included 329 consecutive NOA patients undergoing micro-TESE at our institution. The significance of several factors, including age, testicular volume, etiology and serum levels of FSH, luteinizing hormone (LH) and serum testosterone (T), as predictors of successful sperm retrieval, was evaluated. Results: Of the 329 men included in this series, 246 (74.8 %), 40 (12.2 %), and 43 (13.1 %) were pathologically diagnosed with Sertoli cell only, maturation arrest, and hypospermatogenesis, respectively. Spermatozoa were retrieved in 97 (29.5 %) of these 329 men by micro-TESE. Older age and non-idiopathic etiology were significantly associated with the probability of successful sperm retrieval; however, there were no significant effects of testicular volume as well as serum levels of FSH, LH, and T on sperm retrieval outcome. Furthermore, Johnsen score of the micro-TESE specimen showed a significant association with whether spermatozoa were successfully retrieved. Univariate analysis of preoperative parameters identified older age and non-idiopathic etiology as significant predictors of successful sperm retrieval, of which only etiology appeared to be independently related to successful sperm retrieval on multivariate analysis. Conclusions: Spermatozoa are significantly less likely to be successfully retrieved by micro-TESE in men with idiopathic azoospermia.

  John Wiley and Sons Ltd, Jan. 2016, Reproductive medicine and biology, 15(1) (1), 29 - 33, English, Domestic magazine

  [Refereed]


• 精子形成障害の一因としてのMSH5のメチル化亢進とその発現抑制

  千葉 公嗣, Lamb Doroles J., 藤澤 正人

  (一社)日本内分泌学会, Sep. 2015, 日本内分泌学会雑誌, 91(2) (2), 602 - 602, Japanese


• Male biological clock: a critical analysis of advanced paternal age.

  Ranjith Ramasamy, Koji Chiba, Peter Butler, Dolores J Lamb

  Extensive research defines the impact of advanced maternal age on couples' fecundity and reproductive outcomes, but significantly less research has been focused on understanding the impact of advanced paternal age. Yet it is increasingly common for couples at advanced ages to conceive children. Limited research suggests that the importance of paternal age is significantly less than that of maternal age, but advanced age of the father is implicated in a variety of conditions affecting the offspring. This review examines three aspects of advanced paternal age: the potential problems with conception and pregnancy that couples with advanced paternal age may encounter, the concept of discussing a limit to paternal age in a clinical setting, and the risks of diseases associated with advanced paternal age. As paternal age increases, it presents no absolute barrier to conception, but it does present greater risks and complications. The current body of knowledge does not justify dissuading older men from trying to initiate a pregnancy, but the medical community must do a better job of communicating to couples the current understanding of the risks of conception with advanced paternal age.

  ELSEVIER SCIENCE INC, Jun. 2015, Fertility and sterility, 103(6) (6), 1402 - 6, English, International magazine

  [Refereed]


• MSH5 DEFICIENCIES IN A SUBSET OF NOA MEN

  Koji Chiba, Alex Ridgeway, Larry Lipshultz, Masato Fujisawa, Dolores Lamb

  ELSEVIER SCIENCE INC, Apr. 2015, JOURNAL OF UROLOGY, 193(4) (4), E987 - E988, English

  Summary international conference


• 神経温存前立腺全摘除術後の勃起機能の回復を目的とした低用量バルデナフィルによる陰茎リハビリテーションの有効性の検討

  松下 経, 江夏 徳寿, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本性機能学会, Dec. 2014, 日本性機能学会雑誌, 29(3) (3), 264 - 264, Japanese


• ヒト検体を用いた精巣内ネフリン、ポドシンの発現の検討

  江夏 徳寿, 角井 健太, 福田 輝雄, 松下 経, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2014, 日本生殖医学会雑誌, 59(4) (4), 332 - 332, Japanese


• NBIシステムを用いたラット精巣の観察 Micro-TESEにおける新しい技術への応用を目指した試み

  江夏 徳寿, 角井 健太, 福田 輝雄, 松下 経, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2014, 日本生殖医学会雑誌, 59(4) (4), 333 - 333, Japanese


• Fertility preservation in men with cancer.

  Koji Chiba, Masato Fujisawa

  Due to recent advances in medical technologies, cancer has become more curable and chronic, and post-treatment quality of life, including male fertility, has become an important issue. Cancer itself can affect spermatogenesis through complex interactions, and cancer treatment such as surgery, radiotherapy and chemotherapy, all have certain detrimental effects on spermatogenesis. Currently, sperm cryopreservation before cancer treatment is the mainstay of fertility preservation, and is recommended by numerous guidelines. Although fertility preservation should be discussed with all cancer patients before treatment, it still remains underused. Postpubertal patients who are unable to bank sperm may undergo testicular sperm extraction before treatment. For prepubertal boys, there is no clinically established guideline for fertility preservation. Investigations such as spermatogonial stem cell culture are ongoing, and may lead to clinical options for fertility preservation in the future.

  Oct. 2014, Reproductive medicine and biology, 13(4) (4), 177 - 184, English, Domestic magazine

  [Refereed]


• Extrapleural solitary fibrous tumorに合併したDoege-Potter syndromeの1例

  西岡 遵, 千葉 公嗣, 村蒔 基次, 石村 武志, 田中 一志, 三宅 秀明, 藤澤 正人, 原 重雄

  泌尿器科紀要刊行会, Sep. 2014, 泌尿器科紀要, 60(9) (9), 461 - 461, Japanese


• Henoch-Shonlein紫斑病に乳頭状腎細胞癌を合併した1例

  賀来 泰大, 千葉 公嗣, 村蒔 基次, 石村 武志, 三宅 秀明, 田中 一志, 藤澤 正人

  泌尿器科紀要刊行会, May 2014, 泌尿器科紀要, 60(5) (5), 253 - 253, Japanese


• LOSS OF RA-GEF-2 (RAPGEF6) IN MOUSE CAUSES ALTERED LOCALIZATION OF N-CADHERIN AND CAN CAUSE MALE INFERTILITY

  Keisuke Okada, Koji Chiba, Teruo Fukuda, Noritoshi Enatsu, Kei Matsushita, Hideaki Miyake, Kazuhiro Maeta, Hironori Edamatsu, Toru Kataoka, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2014, JOURNAL OF UROLOGY, 191(4) (4), E741 - E741, English

  Summary international conference


• 顕微鏡下内精静脈低位結紮術後の精液所見の経時的変化に関する検討

  福田 輝雄, 江夏 徳寿, 岡田 桂輔, 千葉 公嗣, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2014, 日本生殖医学会雑誌, 59(1-2) (1-2), 71 - 72, Japanese


• ラット精巣におけるクラスタリンの機能についての検討

  松下 経, 山口 耕平, 福田 輝雄, 江夏 徳寿, 岡田 桂輔, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2014, 日本泌尿器科学会総会, 102回, 645 - 645, Japanese


• LOH症候群患者に対する男性ホルモン補充療法の下部尿路症状への有用性の検討

  福田 輝雄, 岡田 桂輔, 山口 耕平, 江夏 徳寿, 李 福平, 松下 経, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2014, 日本泌尿器科学会総会, 102回, 646 - 646, Japanese


• デュタステリド投与に伴うフリーテストステロンの変化とその意義について

  江夏 徳寿, 山口 耕平, 福田 輝雄, 岡田 佳輔, 松下 経, 千葉 公嗣, 原口 貴裕, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2014, 日本泌尿器科学会総会, 102回, 647 - 647, Japanese


• NEPHRIN-PODOCIN COMPLEX PLAY AN IMPORTANT ROLE IN SPERMATOGENESIS

  Noritoshi Enatsu, Teruo Fukuda, Keisuke Okada, Kei Matsushita, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2014, JOURNAL OF UROLOGY, 191(4) (4), E743 - E743, English

  Summary international conference


• ロボット支援腹腔鏡下腎部分切除術の臨床的検討

  田中 一志, 古川 順也, 重村 克巳, 山口 耕平, 熊野 晶文, 千葉 公嗣, 原田 健一, 日向 信之, 石村 武志, 原口 貴裕, 村蒔 基次, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会総会事務局, Apr. 2014, 日本泌尿器科学会総会, 102回, 505 - 505, Japanese


• 勃起障害の治療

  千葉 公嗣, 藤澤 正人

  (株)医学書院, Mar. 2014, 臨床婦人科産科, 68(2) (2), 260 - 264, Japanese


• 大うつ病を合併した加齢男性性腺機能低下症候群(LOH症候群)患者に対する男性ホルモン補充療法の治療効果に関する検討

  山口 耕平, 江夏 徳寿, 岡田 桂輔, 松下 経, 李 福平, 千葉 公嗣, 三宅 秀明, 田中 一志, 藤澤 正人

  日本老年泌尿器科学会, Nov. 2013, 日本老年泌尿器科学会誌, 26, 103 - 103, Japanese


• 腎門部腫瘍に対するロボット支援腎部分切除術の有用性

  日向信之, 山口耕平, 千葉公嗣, 古川順也, 石村武志, 村薪基次, 原口貴裕, 田中一志, 三宅秀明, 藤澤正人

  日本泌尿器内視鏡学会, Nov. 2013, Jpn J Endorol, 26(3) (3), 229 - 229, Japanese


• RA-GEF-2(Rapgef6)のマウス精子形成における役割

  岡田 桂輔, 山口 耕平, 福田 輝雄, 江夏 徳寿, 李 福平, 松下 経, 千葉 公嗣, 三宅 秀明, 前田 和宏, Bilasy Shymaa E., 枝松 裕紀, 片岡 徹, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2013, 日本生殖医学会雑誌, 58(4) (4), 371 - 371, Japanese


• クラスタリンは熱ストレスから精巣細胞を保護する働きをする可能性がある

  松下 経, 山口 耕平, 福田 輝雄, 江夏 徳寿, 岡田 桂輔, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2013, 日本生殖医学会雑誌, 58(4) (4), 371 - 371, Japanese


• 精巣におけるポドシン、ネフリンの作用メカニズムの究明

  江夏 徳寿, 山口 耕平, 福田 輝雄, 岡田 桂輔, 千葉 公嗣, 松下 経, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2013, 日本生殖医学会雑誌, 58(4) (4), 372 - 372, Japanese


• 陰茎持続勃起症の8例

  松下 経, 山口 耕平, 江夏 徳寿, 李 福平, 岡田 桂輔, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  泌尿器科紀要刊行会, Sep. 2013, 泌尿器科紀要, 59(9) (9), 612 - 612, Japanese


• クラスタリンは熱ストレスによって誘導される傷害から精巣細胞を保護する可能性がある

  松下 経, 山口 耕平, 福田 輝雄, 江夏 徳寿, 李 福平, 岡田 桂輔, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本内分泌学会, Sep. 2013, 日本内分泌学会雑誌, 89(2) (2), 657 - 657, Japanese


• COMPREHENSIVE EVALUATION OF ANDROGEN REPLACEMENT THERAPY FOR MEN WITH LATE-ONSET HYPOGONADISM

  Kohei Yamaguchi, Keisuke Okada, Noritoshi Enatsu, Fuping Li, Kei Matsushita, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  WILEY-BLACKWELL, Jun. 2013, JOURNAL OF SEXUAL MEDICINE, 10, 230 - 230, English

  Summary international conference


• TESTOSTERONE AND MALE INFERTILITY

  Koji Chiba, Kohei Yamaguchi, Hideaki Miyake, Masato Fujisawa

  WILEY-BLACKWELL, Jun. 2013, JOURNAL OF SEXUAL MEDICINE, 10, 202 - 202, English

  Summary international conference


• EFFICIENT TRANSFECTION OF DNA INTO PRIMARILY CULTURED RAT SERTOLI CELLS BY ELECTROPORATION

  Fuping Li, Yamaguchi Kohei, Okada Keisuke, Matsushita Kei, Enatsu Noritoshi, Chiba Koji, Fujisawa Masato

  WILEY-BLACKWELL, May 2013, ANDROLOGY, 1, 89 - 89, English

  Summary international conference


• 精巣におけるポドシンの作用メカニズムの究明

  江夏 徳寿, 山口 耕平, 岡田 桂輔, 李 福平, 松下 経, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2013, 日本生殖医学会雑誌, 58(1-2) (1-2), 71 - 72, Japanese


• CLUSTERIN HAS A POSSIBILITY TO PROTECT THE INJURY OF TESTICULAR CELLS INDUCED BY HEAT SHOCK STRESS

  Kei Matsushita, Kohei Yamaguchi, Noritoshi Enatsu, Fuping Li, Keisuke Okada, Koji Chiba, Hideaki Miyake, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2013, JOURNAL OF UROLOGY, 189(4) (4), E839 - E839, English

  Summary international conference


• 大うつ病を合併したLOH症候群患者に対するARTの治療効果に関する検討

  山口 耕平, 江夏 徳寿, 岡田 桂輔, 松下 経, 李 福平, 千葉 公嗣, 三宅 秀明, 田中 一志, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 294 - 294, Japanese


• HoLEPにおけるラーニングカーブに関する検討

  原口 貴裕, 三宅 秀明, 千葉 公嗣, 田中 一志, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 330 - 330, Japanese


• クラスタリンは熱ストレスによって誘導される損傷から精巣細胞を保護する可能性がある

  松下 経, 山口 耕平, 江夏 徳寿, 李 福平, 岡田 桂輔, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 473 - 473, Japanese


• 精巣におけるポドシンの作用メカニズムの究明

  江夏 徳寿, 山口 耕平, 岡田 桂輔, 松下 経, 李 福平, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 473 - 473, Japanese


• マウス精子形成におけるRA-GEF-2の機能解析

  岡田 桂輔, 山口 耕平, 江夏 徳寿, 李 福平, 松下 経, 千葉 公嗣, 三宅 秀明, 前田 和宏, Bilasy Shymaa E., 枝松 裕紀, 片岡 徹, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 474 - 474, Japanese


• ダビンチSシステムを用いたロボット支援腹腔鏡下腎部分切除術 当院における初期経験

  古川 順也, 田中 一志, 山口 耕平, 熊野 晶文, 千葉 公嗣, 重村 克巳, 日向 信之, 石村 武志, 村蒔 基次, 原口 貴裕, 三宅 秀明, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2013, 日本泌尿器科学会雑誌, 104(2) (2), 284 - 284, Japanese


• Clinical Assessment of Microdissection Testicular Sperm Extraction in 307 Patients with Non-obstructive Azoospermia

  K. Yamaguchi, K. Okada, K. Matsushita, F. Li, M. Ando, K. Chiba, H. Miyake, M. Fujisawa

  ELSEVIER SCIENCE INC, Sep. 2012, UROLOGY, 80(3) (3), S244 - S244, English

  Summary international conference


• ACCURACY OF PREOPERATIVE 3 TESLA MRI IN STAGING PROSTATE CANCER AT ROBOTIC-ASSISTED LAPAROSCOPIC PROSTATECTOMY

  Kazushi Tanaka, Katsumi Shigemura, Kohei Yamaguchi, Koji Chiba, Junya Furukawa, Takahiro Haraguchi, Takeshi Ishimura, Mototsugu Muramaki, Satoru Takahashi, Hideaki Miyake, Masato Fujisawa

  MARY ANN LIEBERT INC, Sep. 2012, JOURNAL OF ENDOUROLOGY, 26, A243 - A244, English

  Summary international conference


• Histopathological Evaluation of Nerve Sparing Technique for Radical Prostatectomy

  K. Tanaka, Y. Nakano, T. Ishimura, J. Furukawa, K. Yamaguchi, K. Chiba, T. Haraguchi, M. Muramaki, H. Miyake, M. Fujisawa

  ELSEVIER SCIENCE INC, Sep. 2012, UROLOGY, 80(3) (3), S293 - S293, English

  Summary international conference


• Significant improving of sperm DNA quality after microsurgical repair of varicocele

  K. Matsushita, K. Yamaguchi, F. Li, K. Okada, M. Ando, K. Chiba, H. Miyake, M. Fujisawa

  ELSEVIER SCIENCE BV, Feb. 2012, EUROPEAN UROLOGY SUPPLEMENTS, 11(1) (1), E59 - U404, English

  Summary international conference


• Expression pattern of testicular claudin-11 in infertile men

  K. Chiba, K. Yamaguchi, K. Okada, K. Matsushita, F. Li, M. Ando, H. Miyake, M. Fujisawa

  ELSEVIER SCIENCE BV, Feb. 2012, EUROPEAN UROLOGY SUPPLEMENTS, 11(1) (1), E51 - U389, English

  Summary international conference


• 顕微鏡下精巣内精子採取術303例の検討

  岡田 桂輔, 山口 耕平, 松下 経, 李 福平, 安藤 慎, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2011, 日本生殖医学会雑誌, 56(4) (4), 335 - 335, Japanese


• 精索静脈瘤患者の術後精液検査所見とホルモン値の経時的変化に関する検討

  安藤 慎, 山口 耕平, 岡田 桂輔, 松下 経, 李 福平, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2011, 日本生殖医学会雑誌, 56(4) (4), 337 - 337, Japanese


• 精索静脈瘤手術は精子DNAの質の改善をもたらす

  千葉 公嗣, 山口 耕平, 岡田 桂輔, 松下 経, 李 福平, 安藤 慎, 三宅 秀明, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2011, 日本生殖医学会雑誌, 56(4) (4), 337 - 337, Japanese


• 精索静脈瘤手術は精子DNAの質の改善をもたらす

  千葉 公嗣, 山口 耕平, 岡田 桂輔, 松下 経, 李 福平, 安藤 慎, 三宅 秀明, 藤澤 正人

  (一社)日本内分泌学会, Sep. 2011, 日本内分泌学会雑誌, 87(2) (2), 716 - 717, Japanese


• 射精障害に対する三環系抗うつ薬の有効性

  岡田 桂輔, 山口 耕平, 松下 経, 安藤 慎, 千葉 公嗣, 三宅 秀明, 藤澤 正人

  (一社)日本性機能学会, Sep. 2011, 日本性機能学会雑誌, 26(2) (2), 209 - 209, Japanese


• 両側精巣固定術後7年後にMicro-TESEを施行し、精子を回収しえた1例

  千葉 公嗣, 山口 耕平, 安藤 慎, 李 福平, 田中 一志, 藤澤 正人

  泌尿器科紀要刊行会, May 2011, 泌尿器科紀要, 57(5) (5), 285 - 285, Japanese


• ヒト精巣組織におけるTight Junction関連蛋白発現の検討

  千葉 公嗣, 山口 耕平, 李 福平, 松下 経, 安藤 慎, 藤澤 正人

  (一社)日本生殖医学会, Apr. 2011, 日本生殖医学会雑誌, 56(1-2) (1-2), 82 - 82, Japanese


• MONO-(2-ETHYLHEXYL) PHTHALATE DECREASES CLAUDIN-11 AND OCCLUDIN IN RAT SERTOLI CELLS

  Koji Chiba, Yutaka Kondo, Fuping Li, Makoto Ando, Kohei Yamaguchi, Tomomoto Ishikawa, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2011, JOURNAL OF UROLOGY, 185(4) (4), E802 - E802, English

  Summary international conference


• THE EXPRESSION AND LOCALIZATION OF TIGHT JUNCTION PROTEINS IN INFERTILE MEN

  Koji Chiba, Kohei Yamaguchi, Kei Matsushita, Fuping Li, Makoto Ando, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2011, JOURNAL OF UROLOGY, 185(4) (4), E802 - E803, English

  Summary international conference


• ラットセルトリ培養細胞におけるMEHPによるシグナル伝達機構の変化とTight Junctionへの影響

  千葉 公嗣, 近藤 有, 李 福平, 安藤 慎, 山口 耕平, 石川 智基, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2011, 日本泌尿器科学会雑誌, 102(2) (2), 369 - 369, Japanese


• 当科における低ゴナドトロピン性性腺機能低下症の臨床的検討

  松下 経, 山口 耕平, 李 福平, 安藤 慎, 千葉 公嗣, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2011, 日本泌尿器科学会雑誌, 102(2) (2), 370 - 370, Japanese


• LOH症候群患者に対するARTの有効性性に関する臨床的検討

  山口 耕平, 李 福平, 安藤 慎, 千葉 公嗣, 石川 智基, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2011, 日本泌尿器科学会雑誌, 102(2) (2), 388 - 388, Japanese


• 当院および関連病院における男性不妊関連手術の検討 2009年4月からの1年半を振り返って

  山口 耕平, 野瀬 隆一郎, 李 福平, 安藤 慎, 千葉 公嗣, 松井 隆, 守殿 貞夫, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2011, 日本泌尿器科学会雑誌, 102(2) (2), 432 - 432, Japanese


• 染色体異常を伴う無精子症症例の臨床的検討

  安藤 慎, 山口 耕平, 李 福平, 松下 経, 千葉 公嗣, 藤澤 正人

  (一社)日本泌尿器科学会, Mar. 2011, 日本泌尿器科学会雑誌, 102(2) (2), 562 - 562, Japanese


• MONO-(2-ETHYLHEXYL) PHTHALATE DECREASES CLAUDIN-11 AND OCCLUDIN IN RAT SERTOLI CELLS

  K. Chiba, Y. Kondo, F. Li, M. Ando, K. Yamaguchi, T. Ishikawa, M. Fujisawa

  ELSEVIER SCIENCE BV, Mar. 2011, EUROPEAN UROLOGY SUPPLEMENTS, 10(2) (2), 219 - 219, English

  Summary international conference


• 高度乏精子症ならびに無精子症における顕微授精成績の検討

  橋本 洋美, 石川 智基, 山口 耕平, 千葉 公嗣, 後藤 栄, 苔口 昭次, 藤澤 正人, 塩谷 雅英

  (一社)日本生殖医学会, Oct. 2010, 日本生殖医学会雑誌, 55(4) (4), 326 - 326, Japanese


• Finasteride内服中止により造精機能が改善した1例

  千葉 公嗣, 山口 耕平, 安藤 慎, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2010, 日本生殖医学会雑誌, 55(4) (4), 405 - 405, Japanese


• 染色体異常を伴う無精子症症例の臨床的検討

  安藤 慎, 千葉 公嗣, 山口 耕平, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2010, 日本生殖医学会雑誌, 55(4) (4), 407 - 407, Japanese


• Microdissection TESEの精子採取の予測因子の検討

  安藤 慎, 山口 耕平, 李 福平, 千葉 公嗣, 石川 智基, 藤澤 正人

  (一社)日本内分泌学会, Sep. 2010, 日本内分泌学会雑誌, 86(2) (2), 450 - 450, Japanese


• Finasteride内服中止により造精機能が改善した1例

  千葉 公嗣, 山口 耕平, 安藤 慎, 越田 光伸, 藤澤 正人

  (一社)日本生殖医学会, Jul. 2010, 日本生殖医学会雑誌, 55(3) (3), 107 - 107, Japanese


• 射精障害13例に対する臨床的検討

  安藤 慎, 山口 耕平, 千葉 公嗣, 藤澤 正人

  泌尿器科紀要刊行会, Jul. 2010, 泌尿器科紀要, 56(7) (7), 412 - 412, Japanese


• POSSIBLE PROGNOSTIC MOLECULAR MARKER FOR TESTICULAR SPERM EXTRACTION IN PATIENTS WITH NON OBSTRUCTIVE AZOOSPERMIA

  Makoto Ando, Kohei Yamaguchi, Koji Chiba, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2010, JOURNAL OF UROLOGY, 183(4) (4), E732 - E732, English

  Summary international conference


• THE MOLECULAR MECHANISMS IN RAT SERTOLI CELL INDUCED BY BISPHENOL A.

  Koji Chiba, Kohei Yamaguchi, Makoto Ando, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2010, JOURNAL OF UROLOGY, 183(4) (4), E732 - E732, English

  Summary international conference


• 化学放射線療法が奏効した原発性女子尿道癌の1例

  八尾 昭久, 丸山 聡, 千葉 公嗣, 田中 宏和, 永田 均

  泌尿器科紀要刊行会, Feb. 2010, 泌尿器科紀要, 56(2) (2), 141 - 141, Japanese


• Human sampleを用いたmicro-TESEの精子採取の予測因子の検討

  安藤 慎, 山口 耕平, 千葉 公嗣, 藤澤 正人

  (一社)日本泌尿器科学会, Feb. 2010, 日本泌尿器科学会雑誌, 101(2) (2), 484 - 484, Japanese


• LOH症候群患者に対するART療法の検討

  千葉 公嗣, 山口 耕平, 安藤 慎, 武中 篤, 藤澤 正人

  (一社)日本泌尿器科学会, Feb. 2010, 日本泌尿器科学会雑誌, 101(2) (2), 486 - 486, Japanese


• Klinefelter症候群に対する顕微鏡下精巣内精子採取術の検討

  千葉 公嗣, 山口 耕平, 安藤 慎, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2009, 日本生殖医学会雑誌, 54(4) (4), 298 - 298, Japanese


• 顕微授精成績における臨床的検討 精子側因子について

  橋本 洋美, 山口 耕平, 千葉 公嗣, 後藤 栄, 苔口 昭次, 藤澤 正人, 塩谷 雅英

  (一社)日本生殖医学会, Oct. 2009, 日本生殖医学会雑誌, 54(4) (4), 303 - 303, Japanese


• 射精障害13例に対する臨床的検討

  安藤 慎, 山口 耕平, 千葉 公嗣, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2009, 日本生殖医学会雑誌, 54(4) (4), 334 - 334, Japanese


• セルトリ細胞におけるビスフェノールAのシグナル伝達機構への影響

  泉 陽子, 山口 耕平, 千葉 公嗣, 安藤 慎, 橋本 洋美, 塩谷 雅英, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2009, 日本生殖医学会雑誌, 54(4) (4), 397 - 397, Japanese


• ビスフェノールAが及ぼすセルトリ細胞内シグナル伝達機構の変化

  山口 耕平, 千葉 公嗣, 安藤 慎, 泉 陽子, 橋本 洋美, 塩谷 雅英, 藤澤 正人

  (一社)日本内分泌学会, Sep. 2009, 日本内分泌学会雑誌, 85(2) (2), 654 - 655, Japanese


• 精巣精子採取術(TESE)の臨床的検討

  石川 智基, 山口 耕平, 千葉 公嗣, 藤澤 正人, 野瀬 隆一郎, 松井 隆, 守殿 貞夫

  (一社)日本生殖医学会, Jul. 2009, 日本生殖医学会雑誌, 54(3) (3), 115 - 115, Japanese


• CISPLATIN REGULATES SERTOLI CELL EXPRESSION OF TRANSFERRIN AND INTERLEUKINS

  Kohei Yamaguchi, Tomomoto Ishikawa, Koji Chiba, Atsushi Takenaka, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2009, JOURNAL OF UROLOGY, 181(4) (4), 684 - 684, English

  Summary international conference


• CAN ORCHIDOPEXY IN ADULTHOOD IMPROVE FERTILITY?

  Koji Chiba, Tomomoto Ishikawa, Kohei Yamaguchi, Atsushi Takenaka, Masato Fujisawa

  ELSEVIER SCIENCE INC, Apr. 2009, JOURNAL OF UROLOGY, 181(4) (4), 786 - 787, English

  Summary international conference


• CAN ORCHIDOPEXY IN ADULTHOOD IMPROVE FERTILITY?

  Koji Chiba, Tomomoto Ishikawa, Kohei Yamaguchi, Masato Fujisawa

  AMER SOC ANDROLOGY, INC, Mar. 2009, JOURNAL OF ANDROLOGY, 30, 60 - 60, English

  Summary international conference


• FERTILIZATION AND PREGNANCY USING CRYOPRESERVED TESTICULAR SPERM FOR INTRACYTOPLASMIC SPERM INJECTION WITH OBSTRUCTIVE AND NON-OBSTRUCTIVE AZOOSPERMIA

  Tomomoto Ishikawa, Masahide Shiotani, Koji Chiba, Kohei Yamaguchi, Masato Fujisawa

  AMER SOC ANDROLOGY, INC, Mar. 2009, JOURNAL OF ANDROLOGY, 30, 41 - 41, English

  Summary international conference


• THE EFFECT OF TESTOSTERONE REPLACEMENT THERAPY ON LIPID METABOLISM IN MEN WITH SYMPTOMATIC LATE-ONSET HYPOGONADISM

  Kohei Yamaguchi, Tomomoto Ishikawa, Koji Chiba, Masato Fujisawa

  AMER SOC ANDROLOGY, INC, Mar. 2009, JOURNAL OF ANDROLOGY, 30, 73 - 73, English

  Summary international conference


• 内分泌・生殖機能・性機能領域 低ゴナドトロピン性性腺機能低下症の診断と治療について

  山口 耕平, 石川 智基, 千葉 公嗣, 武中 篤, 藤澤 正人

  (一社)日本泌尿器科学会, Feb. 2009, 日本泌尿器科学会雑誌, 100(2) (2), 88 - 88, Japanese


• 不妊を伴う停留精巣に対する治療の検討

  千葉 公嗣, 石川 智基, 山口 耕平, 武中 篤, 藤澤 正人

  (一社)日本泌尿器科学会, Feb. 2009, 日本泌尿器科学会雑誌, 100(2) (2), 231 - 231, Japanese


• 高度乏精子症に対する精索静脈瘤手術の検討

  千葉 公嗣, 石川 智基, 山口 耕平, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2008, 日本生殖医学会雑誌, 53(4) (4), 267 - 267, Japanese


• 鼠径ヘルニア根治術と閉塞性無精子症の関連についての検討

  山口 耕平, 石川 智基, 千葉 公嗣, 藤澤 正人

  (一社)日本生殖医学会, Oct. 2008, 日本生殖医学会雑誌, 53(4) (4), 312 - 312, Japanese


• 当院における体腔鏡下腎摘術57例の経験

  八尾 昭久, 千葉 公嗣, 田中 宏和

  (一社)日本泌尿器科学会, Feb. 2008, 日本泌尿器科学会雑誌, 99(2) (2), 422 - 422, Japanese


• 保存的治療により治癒した黄色肉芽腫性腎盂腎炎の1例

  八尾 昭久, 千葉 公嗣, 田中 宏和

  泌尿器科紀要刊行会, Oct. 2007, 泌尿器科紀要, 53(10) (10), 745 - 745, Japanese


• 精索原発Leiomyosarcomaの1例

  千葉 公嗣, 八尾 昭久, 田中 宏和

  泌尿器科紀要刊行会, Oct. 2006, 泌尿器科紀要, 52(10) (10), 821 - 821, Japanese


• 傍尿道膿瘍の1例

  千葉 公嗣, 八尾 昭久, 田中 宏和, 安田 大成

  泌尿器科紀要刊行会, Jul. 2006, 泌尿器科紀要, 52(7) (7), 595 - 595, Japanese


• PARAGANGLIOMA OF THE URINARY BLADDER : A CASE REPORT

  ONO YOSHIHARU, CHIBA KOJI, TANAKA HIROKAZU, YASUDA DAISEI

  日本泌尿器科学会西日本支部, 20 Oct. 2005, The Nishinihon journal of urology, 67(10) (10), 601 - 603, Japanese


• PSA 4ng/ml以下前立腺癌の臨床的検討

  小野 義春, 千葉 公嗣, 田中 宏和

  前立腺全摘術を行ったPSA低値前立腺癌15例の臨床病理学的検討を行った.PSA 4ng/ml以下の15例,4泌尿器科紀要刊行会, Oct. 2005, 泌尿器科紀要, 51(10) (10), 647 - 650, Japanese


• 膀胱Paragangliomaの1例

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  62歳男.肉眼的血尿を主訴とした.膀胱鏡,MRI所見にて膀胱右後壁に粘膜下腫瘍性病変を認め,また,生検による病理組織検査所見より,膀胱paragangliomaと診断した.生検2ヵ月後に経尿道的腫瘍切除を行い,scar周囲を十分にmarginを確保して深部筋層までのdeep resectionを行った.術後25ヵ月現在,再発転移を認めない

  西日本泌尿器科学会, Oct. 2005, 西日本泌尿器科, 67(10) (10), 601 - 603, Japanese


• PSA 4ng/ml以下前立腺癌の臨床的検討

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  泌尿器科紀要刊行会, Jun. 2005, 泌尿器科紀要, 51(6) (6), 424 - 424, Japanese


• 前立腺insignificant cancerは予見可能か?

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  医学図書出版(株), May 2005, 泌尿器外科, 18(臨増) (臨増), 542 - 542, Japanese


• PSA 4ng/ml以下前立腺癌の臨床的検討

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  (一社)日本泌尿器科学会, Mar. 2005, 日本泌尿器科学会雑誌, 96(2) (2), 233 - 233, Japanese


• 局所浸潤性膀胱癌に対する動注化学放射線療法の成績(第2報)

  田中 宏和, 千葉 公嗣, 小野 義春, 松本 修

  西日本泌尿器科学会, Oct. 2004, 西日本泌尿器科, 66(増刊) (増刊), 135 - 135, Japanese


• 尿管結紮術および横行結腸導管を施行した総腸骨動脈尿管瘻の1例

  千葉 公嗣, 小野 義春, 田中 宏和

  西日本泌尿器科学会, Oct. 2004, 西日本泌尿器科, 66(増刊) (増刊), 193 - 193, Japanese


• 前立腺癌cancer volumeならびにpT3の予見にsystematic biopsy所見は有用か?

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  (一社)日本癌治療学会, Sep. 2004, 日本癌治療学会誌, 39(2) (2), 601 - 601, Japanese


• 前立腺癌Cancer volume(PCa vol.)ならびにpT3の予見にSystematic biopsy所見は有益か?

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  泌尿器科紀要刊行会, May 2004, 泌尿器科紀要, 50(5) (5), 363 - 363, Japanese


• 馬蹄鉄腎に発生した化膿性腎嚢胞の1例

  千葉 公嗣, 小野 義春, 田中 宏和

  泌尿器科紀要刊行会, Feb. 2004, 泌尿器科紀要, 50(2) (2), 129 - 130, Japanese


• 集学的治療によりCRを得た浸潤性骨盤内扁平上皮癌の1例

  千葉 公嗣, 小野 義春, 田中 宏和, 安田 大成

  泌尿器科紀要刊行会, Feb. 2004, 泌尿器科紀要, 50(2) (2), 140 - 140, Japanese


• 前立腺Insignificant cancerの臨床的検討

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  泌尿器科紀要刊行会, Nov. 2003, 泌尿器科紀要, 49(11) (11), 693 - 693, Japanese


• 局所浸潤性膀胱癌に対する動注化学放射線療法を中心とした集学的治療

  田中 宏和, 千葉 公嗣, 小野 義春, 松本 修

  西日本泌尿器科学会, Oct. 2003, 西日本泌尿器科, 65(増刊) (増刊), 132 - 132, Japanese


• 前立腺insignificant cancerは予見可能か?

  小野 義春, 千葉 公嗣, 田中 宏和

  (一社)日本癌治療学会, Sep. 2003, 日本癌治療学会誌, 38(2) (2), 651 - 651, Japanese


• 局所浸潤性膀胱癌に対する動注化学放射線療法を中心とした集学的治療

  田中 宏和, 千葉 公嗣, 小野 義春, 松本 修

  (一社)日本癌治療学会, Sep. 2003, 日本癌治療学会誌, 38(2) (2), 773 - 773, Japanese


• 前立腺insignificant cancerの臨床的検討

  小野 義春, 千葉 公嗣, 田中 宏和, 安田 大成

  (一社)日本泌尿器科学会, Feb. 2003, 日本泌尿器科学会雑誌, 94(2) (2), 227 - 227, Japanese


• シルデナフィル投与によるPWV(脈波伝播速度)の変化

  荒川 創一, 千葉 公嗣, 原 勲, 藤澤 正人, 川端 岳, 岡田 弘, 守殿 貞夫

  (一社)日本性機能学会, Dec. 2002, 日本性機能学会雑誌, 17(3) (3), 235 - 236, Japanese


• 前立腺全摘術症例の検討

  千葉 公嗣, 小野 義春, 田中 宏和, 安田 大成

  西日本泌尿器科学会, Nov. 2002, 西日本泌尿器科, 64(増刊) (増刊), 124 - 124, Japanese


• ACTH産生褐色細胞腫の1例

  千葉 公嗣, 原 勲, 原 章二, 三宅 秀明, 川端 岳, 荒川 創一, 守殿 貞夫, 飯田 啓二, 千原 和夫

  泌尿器科紀要刊行会, Sep. 2002, 泌尿器科紀要, 48(9) (9), 573 - 573, Japanese


• ED患者におけるシルデナフィル投与が脈波伝播速度に及ぼす影響

  重村 克巳, 荒川 創一, 千葉 公嗣, 原 勲, 藤澤 正人, 川端 岳, 岡田 弘, 守殿 貞夫

  (一社)日本性機能学会, Aug. 2002, 日本性機能学会雑誌, 17(2) (2), 201 - 201, Japanese

• JMEDJ治療法便覧 / 男性不妊症

  Chiba Koji, 藤澤正人

  Others, 日本医事新報社, 2016, Japanese

  Scholarly book

• 神戸大学における精索静脈瘤の診断

  千葉公嗣, 藤澤正人

  第108回日本泌尿器科学会総会, Dec. 2020

  Nominated symposium


• 神戸大学における結節性硬化症に対するエベロリムスの治療成績

  千葉公嗣, 賀来泰大, 原田健一, 重村克巳, 日向信之, 石村武志, 中野雄造, 藤澤正人

  第108回日本泌尿器科学会総会, Dec. 2020

  Poster presentation


• 無精子症に対する 精索静脈瘤手術の治療成績

  千葉 公嗣,佐藤 克哉, 大西 篤史, 賀来 泰大, 石田 貴樹, 福田 輝雄, 岡田 桂輔, 松下 経, 藤澤 正人

  第65回日本生殖医学会学術講演会, Dec. 2020, Domestic conference

  Oral presentation


• ラットセルトリ細胞のミラベグロンによる分子細胞生物学的影響の検討

  田中 幹人, CHIBA KOJI, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, FUJISAWA MASATO

  第28回 泌尿器科分子・細胞研究会, Feb. 2019, Japanese, 下関, Domestic conference

  Oral presentation


• 膀胱ヘルニアを合併した前立腺癌に対しロボット支援下前立腺全摘除術を施行した1例

  TERAKAWA TOMOAKI, CHIBA KOJI, HARADA KENICHI, SHIGEMURA KATSUMI, ISHIMURA TAKESHI, HINATA NOBUYUKI, NAKANO YUZO, FUJISAWA MASATO

  第31回日本内視鏡外科学会学術総会, Dec. 2018, Japanese, 福岡, Domestic conference

  Poster presentation


• （卒後教育プログラム）男性不妊症の診断と治療

  CHIBA KOJI

  第83回日本泌尿器科学会東部総会, Oct. 2018, Japanese, 東京, Domestic conference

  Public discourse


• ラットセルトリ細胞のミラベグロンによる分子細胞生物学的影響の検討

  田中 幹人, CHIBA KOJI, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, FUJISAWA MASATO

  第68回日本泌尿器科学会中部総会, Oct. 2018, Japanese, 名古屋, Domestic conference

  Poster presentation


• The usage rate of semen cryopreservation before cancer treatment

  Koji Chiba, Masato Fujisawa

  2018 International Joint Meeting of Men’s Health and Aging, Oct. 2018, English, Seoul, International conference

  Poster presentation


• 当院での持続勃起症治療に関する検討

  田中 幹人, CHIBA KOJI, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, FUJISAWA MASATO

  第29回 日本性機能学会学術総会, Sep. 2018, Japanese, 神戸, Domestic conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法の性機能への影響と治療満足度との関連

  FUKUDA TERUO, 田中 幹人, 石田 貴樹, OKADA KEISUKE, CHIBA KOJI, MATSUSHITA KEI, NAKANO YUZO, FUJISAWA MASATO

  第29回 日本性機能学会学術総会, Sep. 2018, Japanese, 神戸, Domestic conference

  Poster presentation


• 摂食障害による男性低ゴナドトロピン性性腺機能低下症の1例

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, 江夏 徳寿, CHIBA KOJI, MATSUSHITA KEI, NAKANO YUZO, FUJISAWA MASATO, AOI TAKASHI

  第18回 日本Men'sHealth医学会, Jul. 2018, Japanese, 東京, Domestic conference

  Poster presentation


• 顕微鏡下精巣精子採取術(microTESE)の治療成績

  CHIBA KOJI, 田中 幹人, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, 塩谷 雅英, FUJISAWA MASATO

  第37回 日本アンドロロジー学会, Jun. 2018, Japanese, 神戸, Domestic conference

  Poster presentation


• ミラベグロンによるラットセルトリ細胞に対する分子機構変化の検討

  田中 幹人, CHIBA KOJI, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, FUJISAWA MASATO

  第37回 日本アンドロロジー学会, Jun. 2018, Japanese, 神戸, Domestic conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法の性機能への影響と治療満足度との関連

  FUKUDA TERUO, 田中 幹人, 石田 貴樹, 角井 健太, OKADA KEISUKE, CHIBA KOJI, MATSUSHITA KEI, NAKANO YUZO, FUJISAWA MASATO

  第37回 日本アンドロロジー学会, Jun. 2018, Japanese, 神戸, Domestic conference

  Poster presentation


• The usage rate of semen cryopreservation before cancer treatment

  Koji Chiba, Mikito Tanaka, Takaki Ishida, Kenta Sumii, Teruo Fukuda, Keisuke Okada, Kei Matsushita, Masato Fujisawa

  The 113th American Urological Association, May 2018, English, San Francisco, International conference

  Poster presentation


• Molecular changes induced by mirabegron in rat Sertoli cell primary culture

  Mikito Tanaka, Koji Chiba, Takaki Ishida, Teruo Fukuda, Keisuke Okada, Kei Matsushita, Masato Fujisawa

  The 113th American Urological Association, May 2018, English, San Francisco, International conference

  Poster presentation


• Interposition of novel nerve-regeneration conduit after wide excision of the neurovascular bundle during radical prostatectomy did not improve postoperative erectile function

  Nobuyuki Hinata, Tomoaki Terakawa, Koji Chiba, Junya Furukawa, Kenichi Harada, Yuzo Nakano, Masato Fujisawa

  AUA annual meeting 2018, May 2018, English, San Francisco, International conference

  Poster presentation


• 神戸大学における低ゴナドトロピン性性腺機能低下症の治療経験

  CHIBA KOJI, FUJISAWA MASATO

  第91回日本内分泌内科学会総会, Apr. 2018, Japanese, 宮崎, Domestic conference

  Oral presentation


• 射精障害に対するアモキサピンおよびイミプラミンの有用性

  MATSUSHITA KEI, CHIBA KOJI, OKADA KEISUKE, FUKUDA TERUO, 角井 健太, 石田 貴樹, 田中 幹人, FUJISAWA MASATO

  第106回日本泌尿器科学会総会, Apr. 2018, Japanese, 京都, Domestic conference

  Poster presentation


• 顕微鏡下精巣精子採取術(microTESE)の治療成績

  CHIBA KOJI, 田中 幹人, 石田 貴樹, FUKUDA TERUO, OKADA KEISUKE, MATSUSHITA KEI, 塩谷 雅英, FUJISAWA MASATO

  第106回日本泌尿器科学会総会, Apr. 2018, Japanese, 京都, Domestic conference

  Poster presentation


• SUMO化阻害によるセルトリ細胞のsignaling pathwayへの影響

  OKADA KEISUKE, 賀來 泰大, 田中 幹人, 石田 貴樹, FUKUDA TERUO, CHIBA KOJI, MATSUSHITA KEI, FUJISAWA MASATO

  第106回日本泌尿器科学会総会, Apr. 2018, Japanese, 京都, Domestic conference

  Poster presentation


• Molecular changes induced by mirabegron in rat Sertoli cell primary culture

  Mikito Tanaka, Koji Chiba, Takaki Ishida, Teruo Fukuda, Keisuke Okada, Kei Matsushita, Masato Fujisawa

  第106回日本泌尿器科学会総会 16th Urological Association of Asia (UAA) Congress 2018, Apr. 2018, English, 京都, International conference

  Poster presentation


• 関節リウマチ、原発性胆汁性肝硬変を合併した腎移植患者に発症した腎移植後リンパ増殖性疾患の1例

  田代 裕己, Ishimura Takeshi, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Harada Kenichi, Matsushita Kei, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第237回 日本泌尿器科学会関西地方会, Feb. 2018, Japanese, 日本泌尿器科学会, 兵庫, Domestic conference

  Oral presentation


• 過度なダイエットによりED、射精障害を認めた1例

  石田 貴樹, 田中 幹人, 角井 健太, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato

  第50回 関西アンドロロジーカンファレンス, Feb. 2018, Japanese, 関西アンドロロジーカンファレンス, 大阪, Domestic conference

  Oral presentation


• 副腎褐色細胞腫に対する腹腔鏡下手術の臨床的検討

  Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Harada Kenichi, Ishimura Takeshi, Matsushita Kei, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第30回 日本内視鏡外科学会総会, Dec. 2017, Japanese, 日本内視鏡外科学会, 京都, Domestic conference

  Poster presentation


• 非閉塞性無精子症に対してサルベージ内分泌療法を施行した2例

  Chiba Koji, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Matsushita Kei, 塩谷 雅英, Fujisawa Masato

  第62回 日本生殖医学会学術講演会, Nov. 2017, Japanese, 日本生殖医学会, 山口, Domestic conference

  Poster presentation


• 男性更年期診療の現状とこれから

  Chiba Koji

  第67回 日本泌尿器科学会中部総会, Nov. 2017, Japanese, 日本泌尿器科学会, 大阪, Domestic conference

  Oral presentation


• 神戸大学におけるTSC-AMLに対するエベロリムスの治療成績

  Harada Kenichi, 坂本 茉莉子, 板東 由加里, 鈴木 光太郎, 原 琢人, 桃園 宏之, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Ishimura Takeshi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第69回 西日本泌尿器科学会総会, Nov. 2017, Japanese, 日本泌尿器科学会, 大分, Domestic conference

  Oral presentation


• クラインフェルター症候群以外の染色体異常を有する非閉塞性無精子症患者の臨床的検討

  角井 健太, 田中 幹人, 石田 貴樹, 岡田 圭輔, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第62回 日本生殖医学会学術講演会, Nov. 2017, Japanese, 日本生殖医学会, 山口, Domestic conference

  Poster presentation


• HoLEP術後の排尿困難改善に術前前立腺 体積、摘出前立腺重量は関連するかの検討

  Shigemura Katsumi, 山道 深, Chiba Koji, 山田 裕二, 岡 康彦, 田中 宏和, 山下 真寿男, Fujisawa Masato

  第31回 日本泌尿器内視鏡学会総会, Nov. 2017, Japanese, 日本泌尿器内視鏡学会, 徳島, Domestic conference

  Public symposium


• 前立腺肥大を有さないLOH症候群患者の血清テストステロン値と夜間頻尿との関係

  田中 幹人, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第17回 日本Men's Health医学会, Oct. 2017, Japanese, 日本Men's Health医学会, 東京, Domestic conference

  Oral presentation


• 術前診断で副腎悪性腫瘍が疑われた副腎Black adenomaの1例

  田代 裕己, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Harada Kenichi, Ishimura Takeshi, Matsushita Kei, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第236回 日本泌尿器科学会関西地方会, Oct. 2017, Japanese, 日本泌尿器科学会, 神戸, Domestic conference

  Oral presentation


• 神戸大学における開腹腎部分切除術と腹腔鏡下腎部分切除術の検討

  角井 健太, Harada Kenichi, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Ishimura Takeshi, Matsushita Kei, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第30回 近畿内視鏡外科研究会, Sep. 2017, Japanese, 近畿内視鏡外科研究会, 大阪, Domestic conference

  Oral presentation


• LOH症候群患者に対する男性ホルモン補充療法の性機能への影響

  田中 幹人, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato

  第28回 日本性機能学会, Sep. 2017, Japanese, 日本性機能学会, 新宿, Domestic conference

  Oral presentation


• HoLEP術後の排尿困難改善に術前前立腺 体積、摘出前立腺重量は関連するかの検討

  Shigemura Katsumi, 山道 深, Chiba Koji, 山田 裕二, 田中 宏和, 岡 康彦, 山下 真寿男, Fujisawa Masato

  第24回 日本排尿機能学会総会, Sep. 2017, Japanese, 日本排尿機能学会, 有明, Domestic conference

  Oral presentation


• 当科における癌治療前凍結保存精子の使用状況

  Chiba Koji, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Matsushita Kei, 塩谷 雅英, Fujisawa Masato

  第36回 日本アンドロロジー学会学術総会, Jun. 2017, Japanese, 日本アンドロロジー学会, 倉敷, Domestic conference

  Poster presentation


• 前立腺肥大を有さないLOH症候群患者の血清テストステロン値と夜間頻尿との関係

  角井 健太, 田中 幹人, 石田 貴樹, 岡田 圭輔, 江夏 徳寿, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第36回 日本アンドロロジー学会学術総会, Jun. 2017, Japanese, 日本アンドロロジー学会, 倉敷, Domestic conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法の長期成績

  田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato

  第36回 日本アンドロロジー学会学術総会, Jun. 2017, Japanese, 日本アンドロロジー学会, 倉敷, Domestic conference

  Poster presentation


• Prospective assessment of psychological symptoms in men with late-onset hypogonadism who received testosterone replacement therapy

  Kenta Sumii, Mikito Tanaka, Takaki Ishida, Teruo Fukuda, Noritoshi Enatsu, Chiba Koji, Matsushita Kei, Fujisawa Masato

  AUA 2017 Annual Meeting, May 2017, English, American Urological Association, Boston, U.S.A, International conference

  Poster presentation


• Clinical outcomes of microsurgical varicocelectomy

  Chiba Koji, Mikito Tanaka, Takaki Ishida, Kenta Sumii, Teruo Fukuda, Noritoshi Enatsu, Matsushita Kei, Fujisawa Masato

  International Congress of Andrology 2017, May 2017, English, International Congress of Andrology, Copenhagen, Denmark, International conference

  Poster presentation


• 神戸大学における転移性腎癌に対する1st lineスニチニブ-2nd lineアキシチニブの検討

  Harada Kenichi, 坂本 茉莉子, 板東 由加里, 鈴木 光太郎, 原 琢人, 桃園 宏之, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Ishimura Takeshi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Oral presentation


• 神戸大学におけるTSC-AMLに対するエベロリムスの治療成績と診療連携の重要性

  Harada Kenichi, 坂本 茉莉子, 板東 由加里, 鈴木 光太郎, 原 琢人, 桃園 宏之, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Ishimura Takeshi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Oral presentation


• 主訴が疼痛である精索静脈瘤に対する手術成績の検討

  田中 幹人, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Fujisawa Masato, 江夏 徳寿

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Poster presentation


• 持続勃起症の9例

  Matsushita Kei, Chiba Koji, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Poster presentation


• 癌治療前の凍結保存精子の使用状況

  Chiba Koji, 田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Matsushita Kei, 塩谷 雅英, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法の長期成績

  田中 幹人, 石田 貴樹, 角井 健太, 江夏 徳寿, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Poster presentation


• LOH症候群患者に対するテストステロン補充療法が精神症状に及ぼす影響

  角井 健太, 田中 幹人, 石田 貴樹, 江夏 徳寿, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Poster presentation


• HoLEPの術者経験数別での手術成績・合併症に関する多施設検討

  Shigemura Katsumi, Chiba Koji, 江夏 徳寿, 安福 富彦, 山道 深, 山田 裕二, 岡 康彦, 田中 宏和, 山下 真寿男, Fujisawa Masato

  第105回 日本泌尿器科学会総会, Apr. 2017, Japanese, 日本泌尿器科学会, 鹿児島, Domestic conference

  Oral presentation


• ヒトiPS細胞由来ホルモン産生Leydig細胞の作製

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato, Aoi Takashi

  第12回 日本生殖再生医学会, Mar. 2017, Japanese, 日本生殖再生医学会, 東京, Domestic conference

  Oral presentation


• Leydig細胞過形成を伴ったクラインフェルター症候群の1例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第49回 関西アンドロロジーカンファレンス, Mar. 2017, Japanese, 日本アンドロロジー学会, 大阪, Domestic conference

  Oral presentation


• 術前にパゾパニブを投与した下大静脈腫瘍塞栓を伴う右腎癌の一例

  前田 光毅, Miyazaki Akira, Enatsu Noritoshi, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Harada Kenichi, Hinata Nobuyuki, Ishimura Takeshi, Nakano Yuzo, Fujisawa Masato

  第234回 日本泌尿器科学会関西地方会, Jan. 2017, Japanese, 日本泌尿器科学会, 京都, Domestic conference

  Oral presentation


• ヒトiPS細胞由来ホルモン産生Leydig細胞の作製（ポスター発表）

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato, Aoi Takashi

  第21回 日本生殖内分泌学会学術集会, Jan. 2017, Japanese, 日本生殖内分泌学会, 大阪, Domestic conference

  Poster presentation


• ヒトiPS細胞由来ホルモン産生Leydig細胞の作製

  石田 貴樹, 田中 幹人, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Nakano Yuzo, Fujisawa Masato, Aoi Takashi

  第21回 日本生殖内分泌学会学術集会, Jan. 2017, Japanese, 日本生殖内分泌学会, 大阪, Domestic conference

  Oral presentation


• 神戸大学における開腹部分切除術と腹腔鏡下部分切除術の検討

  Miyazaki Akira, Furukawa Jyunya, Terakawa Tomoaki, Chiba Koji, 重村 克己, Ishimura Takeshi, Matsushita Kei, Harada Kenichi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第29回 日本内視鏡外科学会, Dec. 2016, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference

  Oral presentation


• ロボット支援根治的前立腺全摘除術における拡大切除および拡大リンパ節廓清の手技と短期成績

  Hinata Nobuyuki, 板東 由加里, 鈴木 光太郎, 桃園 宏之, 今井 聡士, Miyazaki Akira, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Harada Kenichi, Ishimura Takeshi, Nakano Yuzo, Fujisawa Masato

  第29回 日本内視鏡外科学会, Dec. 2016, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference

  Oral presentation


• ラット精巣虚血-再還流障害に対するウロコルチンの生殖細胞保護作用についての検討

  角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第31回 日本生殖免疫学会総会・学術集会, Dec. 2016, Japanese, 日本生殖免疫学会, 神戸, Domestic conference

  Oral presentation


• HoLEPの術者経験数別ごとの手術成績・合併症に関する検討

  Shigemura Katsumi, Chiba Koji, Fujisawa Masato

  第23回 日本排尿機能学会総会, Dec. 2016, Japanese, 日本排尿機能学会, 東京, Domestic conference

  Oral presentation


• 乳房腫大を契機に発見された軽症型アンドロゲン不応症の一例

  石田 貴樹, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Poster presentation


• 当科における低ゴナドトロピン性性腺機能低下症62例の臨床的検討

  福田 輝雄, 田中 幹人, 石田 貴樹, 角井 健太, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Poster presentation


• 当科における精索静脈瘤手術の臨床的検討

  Chiba Koji, 田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Oral presentation


• 男性不妊症患者における非内分泌薬物療法の有用性の検討

  Matsushita Kei, Chiba Koji, Enatsu Noritoshi, 福田 輝雄, 角井 健太, 石田 貴樹, 田中 幹人, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Poster presentation


• 造精機能障害および精巣adrenal rest tumorを伴った先天性副腎皮質過形成の2例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Poster presentation


• 精巣虚血-再還流障害モデルラットを用いた抗アポトーシス蛋白としてのウロコルチンの特性解析

  角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Poster presentation


• 神経非温存ロボット支援根治的前立腺全摘除の際の神経再生誘導チューブ架橋留置が術後短期男性機能に及ぼす影響

  Hinata Nobuyuki, 板東 由加里, 鈴木 光太郎, 桃園 宏之, 今井 聡士, Miyazaki Akira, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Harada Kenichi, Ishimura Takeshi, Nakano Yuzo, Fujisawa Masato

  第30回 日本泌尿器内視鏡学会総会, Nov. 2016, Japanese, 日本泌尿器内視鏡学会, 大阪, Domestic conference

  Oral presentation


• 神経温存ロボット支援根治的前立腺全摘除術後の摘出床へのHA-CM貼付が術後尿禁制に及ぼす影響

  Hinata Nobuyuki, 板東 由加里, 鈴木 光太郎, 桃園 宏之, 今井 聡士, Miyazaki Akira, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Harada Kenichi, Ishimura Takeshi, Nakano Yuzo, Fujisawa Masato

  第30回 日本泌尿器内視鏡学会総会, Nov. 2016, Japanese, 日本泌尿器内視鏡学会, 大阪, Domestic conference

  Oral presentation


• 後腹膜アプローチによるロボット支援腎部分切除術の成績

  Furukawa Jyunya, Terakawa Tomoaki, Chiba Koji, Matsushita Kei, Shigemura Katsumi, Harada Kenichi, Ishimura Takeshi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第30回 日本泌尿器内視鏡学会総会, Nov. 2016, Japanese, 日本泌尿器内視鏡学会, 大阪, Domestic conference

  Oral presentation


• 経尿道的前立腺レーザー手術：HoLEPの術者経験数が手術成績・合併症に影響するかの検討

  Shigemura Katsumi, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Fujisawa Masato

  第30回 日本泌尿器内視鏡学会総会, Nov. 2016, Japanese, 日本泌尿器内視鏡学会, 大阪, Domestic conference

  Public symposium


• ロボット支援根治的前立腺全摘除術の際の拡大切除および拡大リンパ節廓清の手技と初期成績

  Hinata Nobuyuki, 板東 由加里, 鈴木 光太郎, 桃園 宏之, 今井 聡士, Miyazaki Akira, Terakawa Tomoaki, Chiba Koji, Furukawa Jyunya, Harada Kenichi, Ishimura Takeshi, Nakano Yuzo, Fujisawa Masato

  第30回 日本泌尿器内視鏡学会総会, Nov. 2016, Japanese, 日本泌尿器内視鏡学会, 大阪, Domestic conference

  Oral presentation


• デュタステリドが尿路生殖器系に与える影響とホルモンレセプターの発現変化

  Enatsu Noritoshi, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第61回 日本生殖医学会学術講演会・総会, Nov. 2016, Japanese, 日本生殖医学会学, 横浜, Domestic conference

  Oral presentation


• 造精機能障害および精巣adrenal rest tumorを伴った先天性副腎皮質過形成の2例

  田中 幹人, 石田 貴樹, 角井 健太, 福田 輝雄, 岡田 桂輔, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第66回 日本泌尿器科学会中部総会, Oct. 2016, Japanese, 日本泌尿器科学会, 四日市, Domestic conference

  Poster presentation


• Clinical outcomes of microsurgical varicocelectomy.

  Chiba Koji, Mikito Tanaka, Takaki Ishida, Kenta Sumii, Teruo Fukuda, Enatsu Noritoshi, Matsushita Kei, Fujisawa Masato

  The 33rd Japan-Korea Urological Congress, Oct. 2016, English, Japan-Korea Urological Congress, Aomori, JAPAN, International conference

  Oral presentation


• 同一副腎にアルドステロン産生腺腫と褐色細胞腫を認めた一例

  前田 光毅, Chiba Koji, Furukawa Jyunya, Shigemura Katsumi, Harada Kenichi, Ishimura Takeshi, Hinata Nobuyuki, Nakano Yuzo, Fujisawa Masato

  第233回 日本泌尿器科学会関西地方会, Sep. 2016, Japanese, 日本泌尿器科学会, 大阪, Domestic conference

  Oral presentation


• 当科における低ゴナドトロピン性性腺機能低下症62例の臨床的検討

  石田 貴樹, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第34回 日本受精着床学会総会・学術講演会, Sep. 2016, Japanese, 日本受精着床学会, 軽井沢, Domestic conference

  Poster presentation


• The comparison of post-operative erectile function after radical nephrectomy and partial nephrectomy.

  Chiba Koji, Mikito Tanaka, Matsushita Kei, Enatsu Noritoshi, Fujisawa Masato

  The 20th World Meeting on sexula medicine, Sep. 2016, English, International Society for Sexual Medicine, Beijing, CHINA, International conference

  Poster presentation


• LOH症候群患者に対するテストステロン補充療法が精神症状に及ぼす影響

  Chiba Koji, 角井 健太, 田中 幹人, 石田 貴樹, 福田 輝雄, Enatsu Noritoshi, Matsushita Kei, Fujisawa Masato

  第16回 日本Men’s health医学会、第7回テストステロン研究会, Jul. 2016, Japanese, 日本Men’s health医学会, 札幌, Domestic conference

  Oral presentation


• 乳房腫大を契機に発見された軽症型アンドロゲン不応症の一例

  石田 貴樹, 角井 健太, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, Japanese, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• 精子形成障害の一因としてのMSH5過メチル化

  Chiba Koji, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, Japanese, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• デュタステリドが尿路生殖器系に与える影響とホルモンレセプターの発現変化との関係

  Enatsu Noritoshi, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, English, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• LOH症候群患者に対するテストステロン補充療法が精神症状に及ぼす影響についての検討

  角井 健太, 石田 貴樹, 福田 輝雄, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, Japanese, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• Klinefelter症候群に末梢神経障害を合併した1例

  福田 輝雄, 田中 幹人, 石田 貴樹, 角井 健太, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, English, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• Current practice for male infertility at Kobe University Hospital

  Chiba Koji, Fujisawa Masato

  第35回 日本アンドロロジー学会学術集会, Jun. 2016, English, 日本アンドロロジー学会, 群馬, Domestic conference

  Oral presentation


• 精子形成とclusterin発現の関係性

  福田 輝雄, 角井 健太, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第20回 日本生殖内分泌学会, May 2016, Japanese, 日本生殖内分泌学会, 神戸, Domestic conference

  Oral presentation


• The role of urocortin in the apoptosis of germ cells after experimental testicular ischemia-reperfusion injury in the rat

  Kenta Sumii, Chiba Koji, Enatsu Noritoshi, Matsushita Kei, Hideaki Miyake, Fujisawa Masato

  American Urological Association 2016 Annual Meeting L74:AA74+Z87F87L86:X87L86:AC87L86:AA87, May 2016, English, American Urological Association, San Diego, USA, International conference

  Poster presentation


• Seminal level of clusterin in infertile men as a significant biomarker reflecting spermatogenesis

  Teruo Fukuda, Chiba Koji, Enatsu Noritoshi, Matsushita Kei, Fujisawa Masato

  American Urological Association 2016 Annual Meeting L74:AA74, May 2016, English, American Urological Association, San Diego, USA, International conference

  Poster presentation


• Assessment of time-dependent changes in semen parameters in infertile men following microsurgical varicocelectomy

  Teruo Fukuda, Hideaki Miyake, Kenta Sumii, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  American Urological Association 2016 Annual Meeting L74:AA74, May 2016, English, American Urological Association, San Diego, USA, International conference

  Poster presentation


• 非閉塞無精子症患者におけるMSH5 過メチル化の検討

  Chiba Koji, Alex Ridgeway, Doroles J Lamb, Fujisawa Masato

  第104回 日本泌尿器科学会総会, Apr. 2016, Japanese, 日本泌尿器科学会, 宮城, Domestic conference

  Poster presentation


• 当科における低ゴナドトロピン性性腺機能低下症62例の臨床的検討

  福田 輝雄, 石田 貴樹, 角井 健太, Enatsu Noritoshi, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第104回 日本泌尿器科学会総会, Apr. 2016, Japanese, 日本泌尿器科学会, 宮城, Domestic conference

  Poster presentation


• 男性不妊症患者における非内分泌薬物療法の有用性の検討

  Enatsu Noritoshi, 石田 貴樹, 角井 健太, Chiba Koji, Matsushita Kei, Fujisawa Masato

  第104回 日本泌尿器科学会総会, Apr. 2016, Japanese, 日本泌尿器科学会, 宮城, Domestic conference

  Oral presentation


• 腎門部腫瘍に対するロボット支援腎部分切除術の成績

  Furukawa Jyunya, 西川 昌友, Terakawa Tomoaki, Chiba Koji, Shigemura Katsumi, Matsushita Kei, Hinata Nobuyuki, Harada Kenichi, Ishimura Takeshi, 三宅 秀明, 田中 一志, Fujisawa Masato

  第104回 日本泌尿器科学会総会, Apr. 2016, Japanese, 日本泌尿器科学会, 宮城, Domestic conference

  Poster presentation


• ラット精巣虚血-再還流障害に対するウロコルチンの生殖細胞保護作用についての検討

  角井 健太, Chiba Koji, 福田 輝雄, Enatsu Noritoshi, Matsushita Kei, 三宅 秀明, Fujisawa Masato

  第104回 日本泌尿器科学会総会, Apr. 2016, Japanese, 日本泌尿器科学会, 宮城, Domestic conference

  Poster presentation


• The effect of dutasteride on serum free-testosterone and the clinical significance related to testosterone changes.

  Enatsu N, Miyake Hideaki, Matsushita Kei, Chiba Koji, Fujisawa Masato

  10ｔｈ JACMHA（JAPAN-Asean Conference on Men’s Health and Aging）, Nov. 2015, English, The 38th Annual Scientific Meeting of Indonesian Urological Association, バリ, インドネシア, International conference

  Oral presentation


• デュタステリドの血中フリーテストステロンに与える影響とその意義の検討

  江夏 徳寿, 石田 貴樹, 角井 健太, 福田 輝雄, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第15回 日本Men's Health医学会, Sep. 2015, Japanese, 日本Men's Health医学会, 埼玉, Domestic conference

  Oral presentation


• Clusterin produced by Sertoli cells inhibits heat stress-induced apoptosis in rat testis

  Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  15ｔｈ Biennial Meeting of the Asia-Pacific Society for Sexual Medicine, Sep. 2015, English, Asia-Pacific Society for Sexual Medicine, 北京, 中国, International conference

  Poster presentation


• MSH5 Deficiencies in a Subset of NOA Men

  Chiba Koji, Alex Ridgeway, Larry Lipshultz, Fujisawa Masato, Dolores Lamb

  AUA2015 Annual Meeting, May 2015, English, American Urological Association, ニューオリンズ, アメリカ, International conference

  Poster presentation


• Identification of Spermatogenically Active Regions in Rat Testes by Using Narrow Band Imaging System.

  Enatsu N, Miyake Hideaki, Matsushita Kei, Chiba Koji, Fujisawa Masato

  AUA2015 Annual Meeting, May 2015, English, American Urological Association, ニューオリンズ, アメリカ, International conference

  Poster presentation


• Identification of Spermatogenically Active Regions in Rat Testes by Using Narrow Band Imaging System.

  Enatsu N, Miyake Hideaki, Matsushita Kei, Chiba Koji, Fujisawa Masato

  IFFS／JSRM International Meeting 2015, Apr. 2015, English, IFFS／JSRM International Meeting, 横浜, International conference

  Oral presentation


• テストステロン補充療法の適切な効果判定基準の検討

  江夏 徳寿, 角井 健太, 長富 俊孝, 福田 輝雄, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第14回日本メンズヘルス医学会, Sep. 2014, Japanese, 日本メンズヘルス医学会, 大阪, Domestic conference

  Oral presentation


• 非閉塞性無精子症患者における 精子回収とストレス関連タンパクの発現

  福田 輝雄, 江夏 徳寿, 岡田 桂輔, Chiba Koji, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  第33回日本アンドロロジー学会, Jun. 2014, Japanese, 日本アンドロロジー学会, 軽井沢, Domestic conference

  Oral presentation


• 当院における非閉塞性無精子症患者に対する顕微鏡下精子採取術の成績

  江夏 徳寿, 角井 健太, 長富 俊孝, 福田 輝雄, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第33回日本アンドロロジー学会, Jun. 2014, Japanese, 日本アンドロロジー学会, 軽井沢, Domestic conference

  Oral presentation


• The effects of testosterone replacement therapy on lower urinary tract symptoms in men with late onset hypogonadism

  Enatsu N, Sumii K, Ngatoomi T, Fukuda T, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  9th Japan-ASEAN Men’s Health & Aging Conference, May 2014, English, Men’s Health & Aging Conference, ウランバートル, モンゴル, International conference

  Public symposium


• Nephrin-podocin complex as a possible regulator of spermatogenesis

  Enatsu N, Fukuda T, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  109thAUA(American Urological Association)annual meeting, May 2014, English, American Urological Association, オーランド, アメリカ, International conference

  Poster presentation


• 非閉塞性無精子症患者の精巣組織 におけるストレス関連タンパクの発現の意義

  福田 輝雄, 角井 健太, 江夏 徳寿, 岡田 桂輔, Chiba Koji, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  第59回日本生殖医学会学術講演会, Apr. 2014, Japanese, 日本生殖医学会, 東京, Domestic conference

  Public symposium


• 精子形成とCell Junction

  Chiba Koji, 江夏 徳寿, 岡田 桂輔, Fujisawa Masato

  第59回日本生殖医学会学術講演会, Apr. 2014, Japanese, 日本生殖医学会, 東京, Domestic conference

  Public symposium


• ラット精巣におけるクラスタリンの機能についての検討

  Matsushita Kei, 福田 輝雄, 江夏 徳寿, 岡田 桂輔, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第102回日本泌尿器科学会総会, Apr. 2014, Japanese, 日本泌尿器科学会, 神戸, Domestic conference

  Poster presentation


• デュタステリド投与に伴うフリーテストステロンの変化とその意義について

  江夏 徳寿, 福田 輝雄, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第102回日本泌尿器科学会総会, Apr. 2014, Japanese, 日本泌尿器科学会, 神戸, Domestic conference

  Poster presentation


• Nephrin-podocin complex play an important role in spermatogenesis

  Enatsu N, Fukuda T, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  29thEAU(European Association of Urology) Annual Congress, Apr. 2014, English, European Association of Urology, ストックホルム, スウェーデン, International conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法がおよぼすLUTSへの効用

  福田 輝雄, 江夏 徳寿, Chiba Koji, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  第102回日本泌尿器科学会総会, Apr. 2014, Japanese, 日本泌尿器科学会, 神戸, Domestic conference

  Poster presentation


• 顕微鏡下内精静脈低位結紮術後の精液所見の経時的変化に関する検討

  福田 輝雄, 江夏 徳寿, 岡田 桂輔, Chiba Koji, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  第46回関西アンドロロジーカンファレンス, Mar. 2014, Japanese, 日本アンドロロジー学会, 大阪, Domestic conference

  Oral presentation


• 精子機能改善に向けた臨床的取組み（精索静脈瘤手術に伴う精子機能パラメータの変化を中心に）

  江夏 徳寿, 福田 輝雄, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第19回精子研究会, Jan. 2014, Japanese, 日本泌尿器科学会, 神戸, Domestic conference

  Public symposium


• クラスタリンは熱ストレスによって誘導される損傷から精巣細胞を保護する可能性がある

  Matsushita Kei, Yamaguchi Kohei, 福田 輝雄, 江夏 徳寿, 李 福平, 岡田 桂輔, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第18回日本生殖内分泌学会, Dec. 2013, Japanese, 日本生殖内分泌学会, 東京, Domestic conference

  Poster presentation


• 精巣におけるポドシン、ネフリンの作用メカニズム

  江夏 徳寿, Yamaguchi Kohei, 福田 輝雄, 岡田 桂輔, Chiba Koji, Matsushita Kei, Miyake Hideaki, Fujisawa Masato

  第58回日本生殖医学会学術講演会・総会, Nov. 2013, Japanese, 日本生殖医学会学術講演会・総会, 神戸, Domestic conference

  Oral presentation


• 腎門部腫瘍に対するロボット支援腎部分切除術の有用性

  Hinata Nobuyuki, Yamaguchi Kohei, Chiba Koji, Furukawa Jyunya, Ishimura Takeshi, Muramaki Mototsugu, Haraguchi Takahiro, Tanaka Kazushi, Miyake Hideaki, Fujisawa Masato

  第27回日本泌尿器内視鏡学会総会, Nov. 2013, Japanese, 日本泌尿器内視鏡学会総会, 名古屋, Domestic conference

  Oral presentation


• ロボット支援腹腔鏡下腎部分切除術における選択的動脈遮断による部分阻血法の工夫

  Furukawa Jyunya, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Shigemura Katsumi, Ishimura Takeshi, Muramaki Mototsugu, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第27回日本泌尿器内視鏡学会総会, Nov. 2013, Japanese, 日本泌尿器内視鏡学会総会, 名古屋, Domestic conference

  Oral presentation


• ランチョンセミナー悪性腫瘍と男性不妊

  Chiba Koji

  第58回日本生殖医学会学術講演会・総会, Nov. 2013, Japanese, 日本生殖医学会学術講演会・総会, 神戸, Domestic conference

  [Invited]

  Invited oral presentation


• シスプラチンによる精巣内ポドシン、ネフリンの発現変化とARB投与による影響

  江夏 徳寿, Yamaguchi Kohei, 岡田 桂輔, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第63回日本泌尿器科学会 中部総会, Nov. 2013, Japanese, 日本泌尿器科学会 中部総会, 名古屋, Domestic conference

  Poster presentation


• クラスタリンは熱ストレスから精巣細胞を保護する働きをする可能性がある

  Matsushita Kei, Yamaguchi Kohei, 福田 輝雄, 江夏 徳寿, 岡田 桂輔, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第58回日本生殖医学会学術講演会・総会, Nov. 2013, Japanese, 日本生殖医学会学術講演会・総会, 神戸, Domestic conference

  Poster presentation


• RA‐GEF‐2(Rapgef6)のマウス精子形成における役割

  岡田 桂輔, Yamaguchi Kohei, 福田 輝雄, 江夏 徳寿, 李 福平, Matsushita Kei, Chiba Koji, Miyake Hideaki, Maeda Kazuhiro, Shymaa E.Bilasy, Edamatsu Hironori, Kataoka Tohru, Fujisawa Masato

  第58回日本生殖医学会学術講演会・総会, Nov. 2013, Japanese, 日本生殖医学会学術講演会・総会, 神戸, Domestic conference

  Poster presentation


• Clinical outcome of tricyclic antidepressants in infertile men with ejaculatory disorders.

  Enatsu N, Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  9hConference of the Pacific Rim Societyfor Fertility and Sterility, Nov. 2013, English, Conference of the Pacific Rim Societyfor Fertility and Sterility, 神戸, International conference

  Poster presentation


• Extrapleural solitary fibrous tumorに合併したDoege-Potter syndromeの1例

  西岡 遵, Chiba Koji, Muramaki Mototsugu, Ishimura Takeshi, Tanaka Kazushi, Miyake Hideaki, Fujisawa Masato

  第224回日本泌尿器科学会関西地方会, Sep. 2013, Japanese, 日本泌尿器科学会関西地方会, 神戸, Domestic conference

  Oral presentation


• 精子形成と血液精巣関門

  Chiba Koji, Fujisawa Masato

  第31回日本受精着床学会, Aug. 2013, Japanese, 日本受精着床学会, 大分, Domestic conference

  Oral presentation


• 総テストステロン値別による加齢男性性腺機能低下症候群患者の治療効果の検討

  Chiba Koji

  第32回日本アンドロロジー学会学術大会, Jul. 2013, Japanese, 日本アンドロロジー学会学術大会, 大阪, Domestic conference

  Oral presentation


• 精巣におけるポドシン、ネフリンの作用メカニズムの究明

  江夏 徳寿, Yamaguchi Kohei, 岡田 桂輔, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第32回日本アンドロロジー学会学術大会, Jul. 2013, Japanese, 日本アンドロロジー学会学術大会, 大阪, Domestic conference

  Oral presentation


• クラスタリンは熱ストレスによって誘導される損傷から精巣細胞を保護する可能性がある

  Matsushita Kei, Yamaguchi Kohei, 福田 輝雄, 江夏 徳寿, 李 福平, 岡田 桂輔, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第32回日本アンドロロジー学会学術大会, Jul. 2013, Japanese, 日本アンドロロジー学会学術大会, 大阪, Domestic conference

  Poster presentation


• 総テストステロン値別による加齢男性性腺機能低下症候群患者の治療効果の検討

  Chiba Koji, Yamaguchi Kohei, 李 福平, 江夏 徳寿, 岡田 桂輔, Matsushita Kei, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第13回日本抗加齢医学会総会, Jun. 2013, Japanese, 日本抗加齢医学会総会, 横浜, Domestic conference

  Oral presentation


• 大うつ病を合併したLOH症候群患者に対するARTの治療効果に関する検討

  Yamaguchi Kohei, 江夏 徳寿, 岡田 桂輔, Matsushita Kei, 李 福平, Chiba Koji, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第26回日本老年泌尿器科学会, May 2013, Japanese, 日本老年泌尿器科学会, 横浜, Domestic conference

  Poster presentation


• Testosterone and Male Infertility

  Chiba Koji, Yamaguchi Kohei, Miyake Hideaki, Fujisawa Masato

  14ｔｈBiennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), May 2013, English, Biennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), 金沢, International conference

  Oral presentation


• Henoch-Shonlein紫斑病に乳頭状腎細胞癌を合併した1例

  賀來 泰大, Chiba Koji, Muramaki Mototsugu, Ishimura Takeshi, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第223回日本泌尿器科学会関西地方会, May 2013, Japanese, 日本泌尿器科学会関西地方会, 大阪, Domestic conference

  Oral presentation


• Extrapleural solitary fibrous tumorに合併したDoege-Potter syndromeの1例

  西岡 遵, Chiba Koji, Muramaki Mototsugu, Ishimura Takeshi, Tanaka Kazushi, Miyake Hideaki, Fujisawa Masato

  第223回日本泌尿器科学会関西地方会, May 2013, Japanese, 日本泌尿器科学会関西地方会, 大阪, Domestic conference

  Oral presentation


• Critical function of RA-GEF-2 (Rapgef6) in mouse spermatogenesis

  Keisuke Okada, Yamaguchi Kohei, Noritoshi Enatsu, Fuping Li, Matsushita Kei, Chiba Koji, Miyake Hideaki, Maeda Kazuhiro, Shymaa E Bilasy, Edamatsu Hironori, Kataoka Tohru, Fujisawa Masato

  108thAUA(American Urological Association)annual meeting, May 2013, English, AUA(American Urological Association)annual meeting, サンディエゴ, アメリカ, International conference

  Poster presentation


• Clusterin has a possibility to protect the injury of testicular cells induced by heat shock stress

  Matsushita Kei, Yamaguchi Kohei, Enatsu N, Fuping Li, Okada Kenji, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  108thAUA(American Urological Association)annual meeting, May 2013, English, AUA(American Urological Association)annual meeting, サンディエゴ, アメリカ, International conference

  Poster presentation


• Candesartan ameliorates cisplatin induced testicular damage and change of expression pattern of testicular podocin and nephrin

  Enatsu N, Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  108thAUA(American Urological Association)annual meeting, May 2013, English, AUA(American Urological Association)annual meeting, サンディエゴ, アメリカ, International conference

  Poster presentation


• 大うつ病を合併したLOH症候群患者に対するARTの治療効果に関する検討

  Yamaguchi Kohei, 江夏 寿徳, 岡田 桂輔, Matsushita Kei, 李 福平, Chiba Koji, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Poster presentation


• 総テストステロン値別による加齢男性性腺機能低下症候群患者の治療効果の検討

  Chiba Koji, Yamaguchi Kohei, 李 福平, 江夏 寿徳, 岡田 桂輔, Matsushita Kei, Miyake Hideaki, Tanaka Kazushi, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Poster presentation


• 精巣におけるポドシンの作用メカニズムの究明

  江夏 寿徳, Yamaguchi Kohei, 岡田 桂輔, Matsushita Kei, 李 福平, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Oral presentation


• 精子形成障害の新たなメカニズムの解明：RA‐GEF‐2ノックアウトマウスを用いたオス不妊マウスの精子形成能の評価

  Chiba Koji

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  [Invited]

  Invited oral presentation


• ・ダビンチSシステムを用いたロボット支援腹腔鏡下腎部分切除術～当院における初期経験～

  Furukawa Jyunya, Tanaka Kazushi, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Shigemura Katsumi, Hinata Nobuyuki, Ishimura Takeshi, Muramaki Mototsugu, Haraguchi Takahiro, Miyake Hideaki, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Oral presentation


• マウス精子形成におけるRA‐GEF‐6の機能解析

  岡田 桂輔, Yamaguchi Kohei, 江夏 寿徳, 李 福平, Matsushita Kei, Chiba Koji, Miyake Hideaki, Maeda Kazuhiro, Shymaa E.Bilasy, Edamatsu Hironori, Kataoka Tohru, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Poster presentation


• クラスタリンは熱ストレスによって誘導される損傷から精巣細胞を保護する可能性がある

  Matsushita Kei, Yamaguchi Kohei, 江夏 寿徳, 李 福平, 岡田 桂輔, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Poster presentation


• HoLEPにおけるラーニングカーブに関する検討

  Haraguchi Takahiro, Miyake Hideaki, Chiba Koji, Tanaka Kazushi, Fujisawa Masato

  第101回日本泌尿器科学会総会, Apr. 2013, Japanese, 日本泌尿器科学会総会, 札幌, Domestic conference

  Oral presentation


• Comprehensive evaluation of androgen replacement therapy for men with late-onset hypogonadism

  Yamaguchi Kohei, Okada Kenji, Enatsu N, Fuping Li, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  14ｔｈBiennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), Apr. 2013, English, Biennial Meeting of the Asia-Pacific Society for Sexual Medicine (APSSM), 金沢, International conference

  Oral presentation


• Candesartan ameliorates cisplatin induced testicular damage and change of expression pattern of testicular podocin and nephrin

  Enatsu N, Yamamichi F, Okada Kenji, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  28thEAU(European Association of Urology), Mar. 2013, English, EAU(European Association of Urology), ミラノ, イタリア, International conference

  Poster presentation


• Clusterin has a possibility to protect the injury of testicular cells induced by heat shock stress

  Matsushita Kei, Yamaguchi Kohei, Enatsu N, Fuping Li, Okada Kenji, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  10th International Congress of Andrology ( ICA), Feb. 2013, English, International Congress of Andrology ( ICA), メルボルン, オーストラリア, International conference

  Poster presentation


• 選択的腎阻血を行ったロボット支援腹腔鏡下腎部分切除術の検討

  Tanaka Kazushi, Furukawa Jyunya, Shigemura Katsumi, Yamaguchi Kohei, Kumano Masafumi, Chiba Koji, Ishimura Takeshi, Haraguchi Takahiro, Sugimoto Maki, Muramaki Mototsugu, Miyake Hideaki, Fujisawa Masato

  第25回日本内視鏡外科学会総会, Dec. 2012, Japanese, 日本内視鏡外科学会, 横浜, Domestic conference

  Public symposium


• マウス精子形成におけるRA-GEF-2 のノックアウトマウスを用いた機能解析

  岡田桂輔, Yamaguchi Kohei, 江夏徳寿, 李福平, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, Bilasy Shymaa E, Edamatsu Hironori, Kataoka Tohru

  第17回日本生殖内分泌学会学術集会, Dec. 2012, Japanese, 日本生殖内分泌学会, 東京, Domestic conference

  Oral presentation


• マウス精子形成におけるRA-GEF-2のノックアウトマウスを用いた機能解析

  岡田桂輔, Yamaguchi Kohei, 江夏徳寿, 李 福平, Matsushita Kei, Chiba Koji, Miyake Hideaki, Fujisawa Masato, Maeda Kazuhiro, BILASY Shymaa, Edamatsu Hironori, Kataoka Tohru

  第57回日本生殖医学会学術講演会, Nov. 2012, Japanese, 日本生殖医学会, 長崎, Domestic conference

  Oral presentation


• Robotic partial nephrectomy: initial experience

  Shigemura Katsumi, Tanaka Kiwamu, Furukawa Jyunya, Yamaguchi Kohei, Kumano A, Chiba Koji, Ishimura Takeshi, Haraguchi Takahiro, Muramaki Mototsugu, Miyake M, Fujisawa Masato

  30th World Congress of Endourology and SWL, Sep. 2012, English, World Congress of Endourology and SWL, トルコ, International conference

  Poster presentation


• LOH症候群患者に対する男性ホルモン補充療法の有用性に関する検討

  岡田桂輔, 安藤 慎, Yamaguchi Kohei, Matsushita Kei, 李 福平, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第31回日本アンドロロジー学会学術大会, Jun. 2012, Japanese, 日本アンドロロジー学会学術大会, 神戸, Domestic conference

  Oral presentation


• LOH症候群患者に対する男性ホルモン補充療法の有用性に関する検討

  Yamaguchi Kohei, 岡田桂輔, 江夏徳寿, Chiba Koji, Matsushita Kei, 李 福平, Miyake Hideaki, Fujisawa Masato

  第12回 日本抗加齢医学会総会, Jun. 2012, Japanese, 日本抗加齢医学会総会, 横浜, Domestic conference

  Oral presentation


• ・精索静脈瘤患者における術前後のテストステロン産生能に関する検討：メタ分析

  Matsushita Kei, 李 福平, Yamaguchi Kohei, 岡田桂輔, 安藤 慎, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• ・精液検査異常を伴う精索静脈瘤患者の術後経時的変化に関する検討

  Chiba Koji, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李 福平, 安藤 慎, Miyake Hideaki, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• ・顕微鏡下精巣内精子採取術313例の検討

  Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李 福平, 安藤 慎, Chiba Koji, 野瀬隆一郎, 松井 隆, Miyake Hideaki, 守殿貞夫, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• ・顕微鏡下精巣内精子採取術307例の検討

  Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李 福平, 安藤 慎, Chiba Koji, 野瀬隆一郎, 松井 隆, Miyake Hideaki, 守殿貞夫, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• ・経尿道的射精管開放術（TUR-ED）によって精液所見が著明に改善した射精管部分閉塞の1例

  岡田桂輔, Yamaguchi Kohei, Matsushita Kei, 李 福平, 安藤 慎, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• LOH症候群患者における症状と血中遊離型テストステロン値との相関についての検討

  安藤 慎, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李 福平, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第100回 日本泌尿器科学会総会, Apr. 2012, Japanese, 日本泌尿器科学会総会, 横浜, Domestic conference

  Poster presentation


• 精索静脈瘤手術は精子DNDの質の改善をもたらす

  Chiba Koji, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李福平, 安藤慎, Miyake Hideaki, Fujisawa Masato

  第56回日本生殖医学会総会・学術講演会, Dec. 2011, Japanese, 日本生殖医学会総会・学術講演会, 横浜, Domestic conference

  Oral presentation


• 精索静脈瘤患者の術後精液検査所見とホルモン値の経時的変化に関する検討

  安藤慎, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李福平, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第56回日本生殖医学会総会・学術講演会, Dec. 2011, Japanese, 日本生殖医学会総会・学術講演会, 横浜, Domestic conference

  Oral presentation


• 顕微鏡下精巣内精子採取術303例の検討

  岡田桂輔, Yamaguchi Kohei, Matsushita Kei, 李福平, 安藤慎, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第56回日本生殖医学会総会・学術講演会, Dec. 2011, Japanese, 日本生殖医学会総会・学術講演会, 横浜, Domestic conference

  Oral presentation


• 精索静脈瘤手術は精子DNAの質の改善をもたらす

  Chiba Koji, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李福平, 安藤慎, Miyake Hideaki, Fujisawa Masato

  第16回日本生殖内分泌学会学術集会, Nov. 2011, Japanese, 日本生殖内分泌学会学術集会, 東京, Domestic conference

  Poster presentation


• 射精障害に対する三環系抗うつ薬の有効性

  岡田桂輔, Yamaguchi Kohei, Matsushita Kei, 安藤慎, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第22回日本性機能学会学術総会, Sep. 2011, Japanese, 日本性機能学会学術総会, 岡山, Domestic conference

  Oral presentation


• 高度乏精子症患者に対する顕微鏡下内精静脈低位結紮術の効果に関する検討

  Yamaguchi Kohei, 野瀬隆一郎, 李福平, Matsushita Kei, 安藤慎, Chiba Koji, 松井隆, 守殿貞夫, Fujisawa Masato

  第29回日本受精着床学会総会, Sep. 2011, Japanese, 日本受精着床学会総会, 東京, Domestic conference

  Oral presentation


• Efficacy of androgen replacement therapy in men with hypogonadal end-stage renal disease

  Yamaguchi Kohei, Okada Kenji, Matsushita Kei, Li F, Ando M, Chiba Koji, Mityake H, Fujisawa Masato

  28th Korea-Japan Urological Congress, Sep. 2011, English, Korea-Japan Urological Congress, スウォン, 韓国, International conference

  Oral presentation


• 高度乏精子症患者に対する顕微鏡下内精静脈低位結紮術の効果に関する検討

  安藤慎, Yamaguchi Kohei, Matsushita Kei, 李福平, Chiba Koji, Miyake Hideaki, Fujisawa Masato

  第30回日本アンドロロジー学会学術大会第17回精子形成・精巣毒性研究会, Jul. 2011, Japanese, 日本アンドロロジー学会学術大会精子形成・精巣毒性研究会, 東京, Domestic conference

  Oral presentation


• ランチョンセミナー 大うつ病を合併したLOH症候群患者に対するARTの治療効果に関する検討

  Matsushita Kei, Yamaguchi Kohei, 李福平, 安藤慎, Chiba Koji, Fujisawa Masato

  第30回日本アンドロロジー学会学術大会第17回精子形成・精巣毒性研究会, Jul. 2011, Japanese, 日本アンドロロジー学会学術大会精子形成・精巣毒性研究会, 東京, Domestic conference

  Others


• ヒト精巣組織におけるTight Junction関連蛋白発現の検討

  Chiba Koji, Yamaguchi Kohei, 岡田桂輔, Matsushita Kei, 李福平, 安藤慎, Miyake Hideaki, Fujisawa Masato

  第30回日本アンドロロジー学会学術大会第17回精子形成・精巣毒性研究会, Jul. 2011, Japanese, 日本アンドロロジー学会学術大会精子形成・精巣毒性研究会, 東京, Domestic conference

  Oral presentation


• LOH症候群患者に対するARTの有用性に関する検討

  安藤慎, Yamaguchi Kohei, Matsushita Kei, Chiba Koji, Fujisawa Masato

  第11回日本Men's Health医学会, Jun. 2011, Japanese, 日本Men's Health医学会, 神奈川, Domestic conference

  Oral presentation


• Efficacy of androgen replacement therapy in men with hypogonadal end-stage renal disease

  Yamaguchi Kohei, Matsushita Kei, Li F, Ando M, Chiba Koji, Fujisawa Masato

  6th Japan-Asean Conference on Men's Health & Aging, Jun. 2011, English, Japan-Asean Conference on Men's Health & Aging, 鎌倉, International conference

  Oral presentation


• THE EXPRESSION AND LOCALIZATION OF TIGHT JUNCTION PROTEINS IN INFERTILE MEN

  Chiba Koji, Yamaguchi Kohei, Matsushita Kei, Li F, Ando M, Fujisawa Masato

  106th AUA(American Urological Association)annual meeting, May 2011, English, AUA(American Urological Association)annual meeting, ワシントン, アメリカ, International conference

  Poster presentation


• MONO-(2-ETHYLHEXYL) PHTHALATE DECREASES CLAUDIN-11 AND OCCLUDIN IN RAT SERTOLI CELLS

  Chiba Koji, Kondo Y, Li F, Ando M, Yamaguchi Kohei, Ishikawa T, Fujisawa Masato

  106th AUA(American Urological Association)annual meeting, May 2011, English, AUA(American Urological Association)annual meeting, ワシントン, アメリカ, International conference

  Poster presentation


• 当科における低ゴナドトロピン性性腺機能低下症の臨床的検討

  Matsushita Kei, Yamaguchi Kohei, 李福平, 安藤慎, Chiba Koji, Fujisawa Masato

  第99回日本泌尿器科学会総会, Apr. 2011, Japanese, 日本泌尿器科学会総会, 名古屋, Domestic conference

  Oral presentation


• 当院および関連病院における男性不妊関連手術の検討-2009年4月からの1年半を振り返って-

  Yamaguchi Kohei, 野瀬隆一郎, 李福平, 安藤慎, Chiba Koji, 松井隆, 守殿貞夫, Fujisawa Masato

  第99回日本泌尿器科学会総会, Apr. 2011, Japanese, 日本泌尿器科学会総会, 名古屋, Domestic conference

  Poster presentation


• 染色体異常を伴う無精子症症例の臨床的検討

  安藤慎, Yamaguchi Kohei, 李福平, Matsushita Kei, Chiba Koji, Fujisawa Masato

  第99回日本泌尿器科学会総会, Apr. 2011, Japanese, 日本泌尿器科学会総会, 名古屋, Domestic conference

  Poster presentation


• ラットセルトリ培養細胞におけるMEHPによるシグナル伝達機構の変化とTight Junctionへの影響

  Chiba Koji, 近藤有, 李福平, 安藤慎, Yamaguchi Kohei, 石川智基, Fujisawa Masato

  第99回日本泌尿器科学会総会, Apr. 2011, Japanese, 日本泌尿器科学会総会, 名古屋, Domestic conference

  Oral presentation


• LOH症候群患者に対するARTの有効性性に関する臨床的検討

  Yamaguchi Kohei, 李福平, 安藤慎, Chiba Koji, 石川智基, Fujisawa Masato

  第99回日本泌尿器科学会総会, Apr. 2011, Japanese, 日本泌尿器科学会総会, 名古屋, Domestic conference

  Oral presentation


• MONO-(2-ETHYLHEXYL) PHTHALATE DECREASES CLAUDIN-11 AND OCCLUDIN IN RAT SERTOLI CELLS

  Chiba Koji, Kondo Y, Li F, Ando M, Yamaguchi Kohei, Ishikawa T, Fujisawa Masato

  26th EAU(European Association of Urology) Annual Congress, Mar. 2011, English, EAU(European Association of Urology) Annual Congress, ヴィエナ, ウィーン, International conference

  Poster presentation


• Mono-(2-ethylhexyl) phthalate decreases claudin-11 and occludin in rat Sertoli cells

  Chiba Koji, Kondo Y, Ando M, Yamaguchi Kohei, Ishikawa T, Fujisawa Masato

  The 26th Annual Congress of the European Association of Urology, Mar. 2011, English, Annual Congress of the European Association of Urology, Vienna, オーストリア, International conference

  Poster presentation


• 両側精巣固定術後7年後にmicro-TESEを施行し、精子を回収し得た一例

  Chiba Koji, Yamaguchi Kohei, 安藤慎, 李福平, Tanaka Kazushi, Fujisawa Masato

  第60回日本泌尿器科学会中部総会, Nov. 2010, Japanese, 日本泌尿器科学会, 名古屋, Domestic conference

  Oral presentation


• 慢性腎不全を合併したLOH症候群患者に対するART療法の経験

  Yamaguchi Kohei, Chiba Koji, 安藤慎, 李福平, Fujisawa Masato

  第10回日本Men's Health医学会, Nov. 2010, Japanese, 日本Men's Health医学会, 東京, Domestic conference

  Oral presentation


• 染色体異常を伴う無精子症症例の臨床的検討

  安藤慎, Chiba Koji, Yamaguchi Kohei, Fujisawa Masato

  第55回日本生殖医学会総会・学術講演会, Nov. 2010, Japanese, 日本生殖医学会, 徳島, Domestic conference

  Poster presentation


• 高度乏精子症ならびに無精子症における顕微授精成績の検討

  橋本洋美, 石川智基, Yamaguchi Kohei, Chiba Koji, 後藤栄, 苔口昭次, Fujisawa Masato, 塩谷雅英

  第55回日本生殖医学会総会・学術講演会, Nov. 2010, Japanese, 日本生殖医学会, 徳島, Domestic conference

  Oral presentation


• Microdissection TESEの精巣採取の予測因子の検討

  安藤慎, Yamaguchi Kohei, 李福平, Chiba Koji, 石川智基, Fujisawa Masato

  第15回日本生殖内分泌学会, Nov. 2010, Japanese, 日本生殖内分泌学会, 大阪, Domestic conference

  Oral presentation


• Finasteride内服中止により造精機能が改善した1例

  Chiba Koji, Yamaguchi Kohei, 安藤慎, Fujisawa Masato

  第55回日本生殖医学会総会・学術講演会, Nov. 2010, Japanese, 日本生殖医学会, 徳島, Domestic conference

  Poster presentation


• The efficacy of adult orchidopexy on fertility

  Chiba Koji, Yamaguchi Kohei, Ando M, Fujisawa Masato

  Japan-Korea Urological Congress, Sep. 2010, English, 日韓泌尿器科学会, 京都, International conference

  Oral presentation


• microdissection TESEの精子採取の予測因子の検討

  安藤慎, Yamaguchi Kohei, 石川智基, Chiba Koji, 李福平, Fujisawa Masato

  第29回日本アンドロロジー学会, Jul. 2010, Japanese, 日本アンドロロジー学会, 東京, Domestic conference

  Oral presentation


• The molecular mechanisms in rat sertoli cell induced by Bisphenol A.

  Chiba Koji, Yamaguchi Kohei, Ando M, Fuping L, Izumi Yasushi, Ishikawa T, Tanaka Kiwamu, Takenaka A, Fujisawa Masato

  105th AUA(American Urological Association)annual meeting, May 2010, English, 米国泌尿器科学会, サンフランシスコ, アメリカ, International conference

  Oral presentation


• Possible Prognostic Molecular Marker for Testicular Sperm Extraction in Patients with Non Obstructive Azoospermia

  Ando M, Yamaguchi Kohei, Ishikawa T, Chiba Koji, Tanaka Kiwamu, Takenaka A, Fujisawa Masato

  105th AUA(American Urological Association)annual meeting, May 2010, English, 米国泌尿器科学会, サンフランシスコ, アメリカ, International conference

  Oral presentation


• LOH症候群患者に対するART療法の検討

  Chiba Koji, Yamaguchi Kohei, 安藤慎, 武中篤, Fujisawa Masato

  第98回日本泌尿器科学会総会, Apr. 2010, Japanese, 日本泌尿器科学会, 盛岡, Domestic conference

  Poster presentation


• Human sampleを用いたmicro-TESEの精子採取の予測因子

  安藤慎, Yamaguchi Kohei, Chiba Koji, Fujisawa Masato

  第98回日本泌尿器科学会総会, Apr. 2010, Japanese, 日本泌尿器科学会, 盛岡, Domestic conference

  Poster presentation


• Finasteride内服中止により造精機能が改善した1例

  Chiba Koji, Yamaguchi Kohei, 安藤 慎, 越田光伸, Fujisawa Masato

  第40回関西アンドロロジーカンファレンス, Mar. 2010, Japanese, 関西アンドロロジーカンファレンス, 大阪, Domestic conference

  Oral presentation


• 射精障害13例に対する臨床的検討

  安藤慎, Yamaguchi Kohei, Chiba Koji, Fujisawa Masato

  第54回日本生殖医学会・学術講演会, Nov. 2009, Japanese, 日本生殖医学会, 金沢, Domestic conference

  Poster presentation


• 顕微授精成績における臨床的検討-精子側因子について-

  橋本洋美, Yamaguchi Kohei, Chiba Koji, 後藤栄, 苔口昭次, Fujisawa Masato, 塩谷雅英

  第54回日本生殖医学会・学術講演会, Nov. 2009, Japanese, 日本生殖医学会, 金沢, Domestic conference

  Oral presentation


• ビスフェノールAが及ぼすセルトリ細胞内シグナル伝達機構の変化

  Yamaguchi Kohei, Chiba Koji, 安藤 慎, 泉陽子, 橋本洋美, 塩谷雅英, Fujisawa Masato

  第14回日本生殖内分泌学会, Nov. 2009, Japanese, 日本生殖内分泌学会, 東京, Domestic conference

  Oral presentation


• セルトリ細胞におけるビスフェノールAのシグナル伝達機構への影響

  泉陽子, Yamaguchi Kohei, Chiba Koji, 安藤慎, 橋本洋美, 塩谷雅英, Fujisawa Masato

  第54回日本生殖医学会・学術講演会, Nov. 2009, Japanese, 日本生殖医学会, 金沢, Domestic conference

  Poster presentation


• Klinefelter症候群に対する顕微鏡下精巣採取術の検討

  Chiba Koji, Yamaguchi Kohei, 安藤慎, Fujisawa Masato

  第54回日本生殖医学会・学術講演会, Nov. 2009, Japanese, 日本生殖医学会, 金沢, Domestic conference

  Oral presentation


• 両側精巣固定術後7年後にmicro-TESEを施行し、精子を回収し得た1例

  Chiba Koji, Yamaguchi Kohei, 安藤 慎, Fujisawa Masato

  第39回関西アンドロロジーカンファレンス, Oct. 2009, Japanese, 関西アンドロロジーカンファレンス, 大阪, Domestic conference

  Oral presentation


• 射精障害13例に対する臨床的検討

  安藤慎, Yamaguchi Kohei, Chiba Koji, Fujisawa Masato

  第59回日本泌尿器科学会中部総会, Oct. 2009, Japanese, 日本泌尿器科学会, 金沢, Domestic conference

  Oral presentation


• The efficacy of testosterone replacement therapy in men with late-onset hypogonadism

  Yamaguchi Kohei, Chiba Koji, Makoto Ando, Masato Fjisawa

  第5回APSSAM(Asia Pacific Society for the Study of Aging Male), Oct. 2009, English, ISSAM(International Society for the Study of Aging Male), 大阪, International conference

  Others


• 当科における低ゴナドトロピン性性腺機能低下症37例の臨床的検討

  Chiba Koji, Yamaguchi Kohei, 安藤慎, 武中篤, Fujisawa Masato

  第28回日本アンドロロジー学会総会, Jul. 2009, Japanese, 日本アンドロロジー学会, 富山, Domestic conference

  Oral presentation


• 不妊を伴う停留精巣に対する治療の検討

  Chiba Koji, 石川智基, Yamaguchi Kohei, 武中篤, Fujisawa Masato

  第97回日本泌尿器科学会総会, Apr. 2009, Japanese, 日本泌尿器科学会, 岡山, Domestic conference

  Oral presentation


• JUAアップデートセッション パネルディスカッション6「内分泌・生殖機能・性機能領域 」 低ゴナドトロピン性性腺機能低下症の診断と治療について

  Yamaguchi Kohei, 石川智基, Chiba Koji, 武中篤, Fujisawa Masato

  第97回日本泌尿器科学会総会, Apr. 2009, Japanese, 日本泌尿器科学会, 岡山, Domestic conference

  Public symposium


• CISPLATIN REGULATES SERTOLI CELL EXPRESSION OF TRANSFERRIN AND INTERLEUKINS

  Yamaguchi Kohei, Tomomoto Ishikawa, Chiba Koji, Atsushi Takenaka, Fujisawa Masato

  第104回ＡＵＡ（Amerigcan Urological Association）, Apr. 2009, English, 米国泌尿器科学会, シカゴ, アメリカ, International conference

  Poster presentation


• CAN ORCHIDOPEXY IN ADULTHOOD IMPROVE FERTILITY?

  Chiba Koji, Tomomoto Ishikawa, Yamaguchi Kohei, Atsushi Takenaka, Fujisawa Masato

  第104回ＡＵＡ（Amerigcan Urological Association）, Apr. 2009, English, 米国泌尿器科学会, シカゴ, アメリカ, International conference

  Poster presentation


• 化学放射線療法が泰効した原発性女子尿道癌の1例

  Chiba Koji

  第205回日本泌尿器科学会関西地方会, Dec. 2008, Japanese, 日本泌尿器科学会関西地方会, 大阪, Domestic conference

  Oral presentation


• ＬＯＨ症候群患者に対するＡＲＴ療法の脂質代謝への影響

  Yamaguchi Kohei, Ishikawa Tomomoto, Chiba Koji, Takenaka Atsushi, Fujisawa Masato

  第8回日本Men’s Health医学会, Nov. 2008, Japanese, 日本Men’s Health医学会, 東京, Domestic conference

  Oral presentation


• 鼠径ヘルニア根治術と閉塞性無精子症の関連についての検討

  Yamaguchi Kohei, Ishikawa Tomomoto, Chiba Koji, Fujisawa Masato

  第53回日本生殖医学会, Oct. 2008, Japanese, 日本生殖医学会, 神戸, Domestic conference

  Oral presentation


• 高度乏精子症に対する精索静脈瘤手術の検討

  Chiba Koji, Ishikawa Tomomoto, Yamaguchi Kohei, Fujisawa Masato

  第53回日本生殖医学会, Oct. 2008, Japanese, 日本生殖医学会, 神戸, Domestic conference

  Oral presentation


• Microdissection TESE術後におけるホルモン値変化の検討

  Yamaguchi Kohei, Ishikawa Tomomoto, Chiba Koji, Takenaka Atsushi, Fujisawa Masato

  第27回日本アンドロロジー学会, Jul. 2008, Japanese, 日本アンドロロジー学会, 京都, Domestic conference

  Oral presentation


• MD-TESE術前精子回収予測因子の検討と新規マーカーの可能性

  Ishikawa Tomomoto, Haraguchi Takahiro, Chiba Koji, Yamaguchi Kohei, Takenaka Atsushi, Fujisawa Masato

  第27回日本アンドロロジー学会, Jul. 2008, Japanese, 日本アンドロロジー学会, 京都, Domestic conference

  Oral presentation

• 【基盤C】LOH症候群に対する治療薬開発の基盤となり得る老化Leydig様細胞の作製

  三宅 秀明, 千葉公嗣, 佐藤克哉

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, Apr. 2025 - Mar. 2028


• ヒトiPS細胞由来テストステロン産生Leydig細胞の作製と臨床応用に関する実験

  藤澤 正人, 重村 克巳, 青井 貴之, 石田 貴樹, 千葉 公嗣

  日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023

  本研究の目的は、テストステロン産生能を有する人工Leydig細胞を作製し、それを免疫隔離デバイスに入れてラットの体内へ移植し、テストステロンを分泌することを確かめることである。 これまでに我々は、ヒトiPS細胞にNR5A1というマスター遺伝子を強制発現させることで、テストステロン産生能を有するLeydig細胞への分化誘導に成功していた。しかし遺伝子を強制発現させる方法としてTet-ONシステムを用いており、このシステムを稼働させるためにはドキシサイクリンを添加し続ける必要があるため、臨床応用に向けて課題を有していた。そこで今回我々は、NR5A1恒常発現系を作製することで、Tet-ONシステムに依存しないヒトiPS細胞由来Leydig細胞を作製することを試みた。具体的には恒常発現プロモーター下にNR5A1を発現するプラスミドをエレクトロポレーション法でヒトiPS細胞へ導入することで、NR5A1を強制発現させ、従来のように分化誘導を行った。しかしこれだけでは培養上清中のテストステロン濃度の上昇が見られなかったため、さらに中胚葉指向性を高めるために培養条件を改良した上で、胚様体形成を介した分化誘導を行った。このようにして得られた細胞における培養上清中のテストステロン濃度を測定したところ有意なテストステロン濃度上昇があったことから、Tet-ONシステムに依存せずにNR5A1を恒常発現し続けるLeydig細胞の作製に成功したと言える。 また、ヒトiPS細胞由来の人工Leydig細胞を、アルギン酸ビーズ化してラットの後腹膜腔に移植したところ、移植20日目に血清テストステロン濃度の上昇（0.36ng/mL）を認めた。


• Analysis of function of rapgef6 in spermatogenesis and development of new male infertility treatment

  Fujisawa Masato

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019

  We have found that rapgef6 knockout (KO) mice exhibit prominent male infertility and analyzed the mechanism underlying rapgef6’s function in the process of spermatogenesis. Although the body weight and pituitary hormones levels showed no difference between KO and wild mice, testis volume was significantly low in KO mice. The concentration and motility of epididymal sperm was decreased. Malformed sperms were ubiquitously observed in KO mice. Histological examination showed marked atrophy of the testis and hypospermatogenesis in KO mice. Because rapgef6 was expressed on the luminal side of seminiferous tubules, it could be related to the apical ectoplasmic specialization (ES) that maintains the polarity of the spermatids and confers adhesion to Sertoli cells in the semiferous epithelium. We found that loss of rapgef6 altered the expression of ZO-1 beside with N-cadherin. We cannot detect any rapgef6 expressions in human testis in this research. This is next challenge for the future.

  Competitive research funding


• Significance of oxidative stress in male infertility and exploration of new treatments

  Chiba Koji

  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2014 - 31 Mar. 2018

  In the model group which gave heat stress to rats and artificially twisted torsion, it was possible to induce significant oxidative stress for rat testes. The lower body of the rat in the heat stress group soaked for 15 minutes in boiling water of 43 ℃, showed a decrease in testicular weight and sperm number, the apoptosis index is maximized after one day of thermal stress was shown.Furthermore, Clusterin is a chaperone protein that protects the cells from oxidative stress, it has been shown to enhance the expression over time after thermal stress.As a result of examining the testes of the torsion rat, the expression of the scale-ching which has been reported to exhibit anti-apoptosis effect on myocardial ischemia was observed in reproductive cells.


• 男性不妊における酸化ストレスの意義と新しい治療法の探求

  千葉 公嗣

  学術研究助成基金助成金／基盤研究(C), Apr. 2014 - Mar. 2017, Principal investigator

  Competitive research funding