Research activity information

• Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosis.

  Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Shusuke Numata, Tomohiko Nakayama, Tomohiro Yoshida, Kentaro Mouri, Ikuo Otsuka, Noboru Hiroi, Akitoyo Hishimoto

  Schizophrenia is a common chronic psychiatric disorder that causes age-related dysfunction. The life expectancy in patients with schizophrenia is ≥10 years shorter than that in the general population because of the higher risk of other diseases, such as cardiovascular diseases. Aging studies based on DNA methylation status have received considerable attention. Several epigenetic age accelerations and predicted values of aging-related proteins (GrimAge and GrimAge2 components) have been analyzed in multiple diseases. However, no studies have investigated up to GrimAge and GrimAge2 components between patients with schizophrenia and controls. Therefore, we aimed to conduct multiple regression analyses to investigate the association between schizophrenia and epigenetic age accelerations and GrimAge and GrimAge2 components in seven cohorts. Furthermore, we included patients with first-episode psychosis whose illness duration was often shorter than schizophrenia in our analysis. We integrated these results with meta-analyses, noting the acceleration of GrimAge, GrimAge2, and DunedinPACE, and increase in adrenomedullin, beta-2 microglobulin, cystatin C, and plasminogen activation inhibitor-1 levels, in patients with schizophrenia or first-episode psychosis. These results corroborated the finding that patients with schizophrenia had an increased risk of diabetes, cardiovascular disease, and cognitive dysfunction from a biological perspective. Patients with schizophrenia and first-episode psychosis showed differences in the results when compared with controls. Such analyses may lead to the development of novel therapeutic targets to patients with schizophrenia or relevant diseases from the perspective of aging in the future.

  Nov. 2024, Schizophrenia (Heidelberg, Germany), 10(1) (1), 108 - 108, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Comprehensive analysis including in-game spending and violent game playing in patients with internet gaming disorder.

  Haruka Minami, Toshiyuki Shirai, Shohei Okada, Masao Miyachi, Takaki Tanifuji, Satoshi Okazaki, Tadasu Horai, Kentaro Mouri, Ikuo Otsuka, Akitoyo Hishimoto

  AIM: Internet gaming disorder (IGD) is receiving increasing attention. In particular, violent gameplay or in-game spending affects the psychiatric conditions and economic difficulties of patients. We conducted regression analysis and path analysis to investigate the associations between a comprehensive list of factors in patients with IGD, including the degree of internet or gaming dependence, developmental problems, family background, severity of depression, sleeping habits, in-game spending, and first-person shooter (FPS) and third-person shooter (TPS) game playing. METHODS: The participants were 47 Japanese individuals (39 males and 8 females) aged ≤20 years diagnosed with IGD with complete data from the internet addiction test, autism spectrum quotient, Quick Inventory of Depressive Symptomatology, and Pittsburgh Sleep Quality Index. All participants were asked whether their parents have divorce history, whether they have siblings, whether they play FPS or TPS games, and whether they engage in in-game spending. Firstly, we compared these factors between males and females; secondly, we conducted regression analysis and path analysis in male patients. RESULTS: As for simple comparison between sex, female patients showed greater severity of IGD and depressive score. In regression analysis of male patients, significant associations were found between FPS or TPS game playing and in-game spending. We also created path diagrams. CONCLUSION: The results of the comprehensive analyses suggest the possibility that bidirectional synergistic effects could be achieved by gradually reducing both violent game playing and in-game spending. The concept of internet dependence has a wide range of meanings, and for each subtype, it is important to consider the background that led to the dependence to make individualized environmental adjustments and provide psychotherapy.

  Jul. 2024, Neuropsychopharmacology reports, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Accelerated epigenetic aging in alcohol dependence.

  Toshiyuki Shirai, Satoshi Okazaki, Ikuo Otsuka, Masao Miyachi, Takaki Tanifuji, Ryota Shindo, Shohei Okada, Haruka Minami, Tadasu Horai, Kentaro Mouri, Akitoyo Hishimoto

  Alcohol dependence poses a global health threat associated with aging and reduced life expectancy. Recently, aging research through deoxyribonucleic acid (DNA) methylation has gained attention. New epigenetic clocks have been developed; however, no study has investigated GrimAge components, GrimAge2 components and DunedinPACE in patients with alcohol dependence. In this study, we aimed to perform epigenetic clock analysis to evaluate epigenetic age acceleration and DNA methylation-based age-predictive components in patients with alcohol dependence and controls. We utilized publicly available DNA methylation data (GSE98876) for our analysis. Additionally, we compared the values of the same items before and after the patients underwent a treatment program. The dataset comprised 23 controls and 24 patients. We observed that DunedinPACE accelerated more in patients with alcohol dependence. AgeAccelGrim and AgeAccelGrim2 decelerated more after the treatment program than before, and beta-2-microglobulin and Cystatin C decreased after the treatment program than before. These findings are crucial as they affect the cranial nerve area, potentially contributing to cognitive dysfunction and psychiatric symptoms in patients with alcohol dependence.

  May 2024, Journal of psychiatric research, 173, 175 - 182, English, International magazine

  Scientific journal


• Association study of a single nucleotide polymorphism in the hypoxia response element of the macrophage migration inhibitory factor gene promoter with suicide completers in the Japanese population.

  Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Masao Miyachi, Shohei Okada, Ryota Shindo, Tadasu Horai, Kentaro Mouri, Motonori Takahashi, Takeshi Kondo, Yasuhiro Ueno, Akitoyo Hishimoto

  BACKGROUND: More than 800 000 people die by suicide annually. The heritability of suicide is 30%-50%. We focused on the hypoxia response element (HRE), which promotes the expression of macrophage migration inhibitory factor (MIF) via the hypoxia-inducible factor (HIF) pathway, important in neurogenesis and neuroprotection. We examined a genetic polymorphism of rs17004038, a single-nucleotide polymorphism (SNP), in suicide completers and controls. METHODS: The study population included 1336 suicide completers and 814 unrelated healthy controls. All participants were Japanese. We obtained peripheral blood, extracted DNA, and genotyped the patients for SNP rs17004038 (C > A). RESULTS: No significant differences were observed between the two groups in either the allele or genotype analyses. Subgroup analyses by sex, age (<40 or ≥40), and suicide method (violent or nonviolent suicide) were performed with similar results. CONCLUSION: No association was observed between SNP rs17004038 and suicide completion. Although it is challenging to collect a large number of samples from suicide completers, further MIF-related genetic studies, including those of rs17004038, are necessary with larger sample sizes.

  Mar. 2024, Neuropsychopharmacology reports, 44(1) (1), 262 - 266, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Epigenome-wide association study on methamphetamine dependence.

  Toshiyuki Shirai, Satoshi Okazaki, Takaki Tanifuji, Ikuo Otsuka, Tadasu Horai, Kentaro Mouri, Yukihiro Takemura, Katsuro Aso, Noriya Yamamoto, Akitoyo Hishimoto

  Repeated abuse of methamphetamine (METH) can cause dependence, repeated relapse of psychotic symptoms, compulsive drug-seeking behaviour, and various neurological symptoms. These long-term biological changes may be associated with epigenetic mechanisms; however, the association between METH use and epigenetic mechanisms has been poorly investigated. Thus, we performed an epigenome-wide association study of METH dependence using genomic DNA extracted from the blood samples of 24 patients with METH dependence and 24 normal controls. All participants were of Japanese descent. We tested the association between METH dependence and DNA methylation using linear regression analysis. We found epigenome-wide significant associations at four CpG sites, one of which occurred in the CNOT1 gene and another in the PUM1 gene. We especially noted the CNOT1 and PUM1 genes as well as several other genes that indicated some degree of association with METH dependence. Among the relatively enriched Gene Ontology terms, we were interested in terms of mRNA metabolism, respirasome, and excitatory extracellular ligand-gated ion channel activity. Among the relatively enriched Kyoto Encyclopedia of Genes and Genome pathways, we noted pathways of several neurological diseases. Our results indicate that genetic changes akin to those in other psychiatric or neurodegenerative disorders may also occur via epigenetic mechanisms in patients with METH dependence.

  Mar. 2024, Addiction biology, 29(3) (3), e13383, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder.

  Ryota Shindo, Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Toshiyuki Shirai, Kentaro Mouri, Tadasu Horai, Akitoyo Hishimoto

  Major depressive disorder (MDD) is known to cause significant disability. Genome-wide DNA methylation (DNAm) profiles can be used to estimate biological aging and as epigenetic clocks. However, information on epigenetic clocks reported in MDD patients is inconsistent. Since antidepressants are likely confounders, we evaluated biological aging using various DNAm-based predictors in patients with MDD who had never received depression medication. A publicly available dataset consisting of whole blood samples from untreated MDD patients (n = 40) and controls (n = 40) was used. We analyzed five epigenetic clocks (HorvathAge, HannumAge, SkinBloodAge, PhenoAge, and GrimAge), DNAm-based telomere length (DNAmTL), and DNAm-based age-related plasma proteins (GrimAge components), as well as DNAm-based white blood cell composition. The results indicate that patients with untreated MDD were significantly associated with epigenetic aging acceleration in HannumAge and GrimAge. Furthermore, a decrease in natural killer cells, based on DNAm, was observed in patients with untreated MDD.

  Sep. 2023, npj aging, 9(1) (1), 19 - 19, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 再雇用就労における産業医の役割について 10年間の集計結果より

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 足立 祥, 毛利 健太朗, 楠田 康子, 林原 礼子, 近藤 泰子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 岡本 眞知子, 三村 祐子, 和田 矩子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2023, CAMPUS HEALTH, 60(1) (1), 69 - 71, Japanese


• 新型コロナウイルス感染症(COVID-19)による環境変化が教職員に与えた精神的ストレスの評価

  毛利 健太朗, 足立 祥, 飛松 崇子, 高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 別祖 香代, 和田 矩子, 藤平 和弘, 谷藤 貴紀, 青山 慎介, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2023, CAMPUS HEALTH, 60(1) (1), 75 - 76, Japanese


• コロナ禍前後の大学生における体重変化の実態 神戸大学での検討

  飛松 崇子, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 別祖 香代, 和田 矩子, 足立 祥, 毛利 健太朗, 高橋 健太郎, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2023, CAMPUS HEALTH, 60(1) (1), 124 - 125, Japanese


• コロナ禍における「こころの健康相談」新規来所者の診断分類の変化について

  近藤 泰子, 足立 祥, 毛利 健太朗, 楠田 康子, 飛松 崇子, 高橋 健太郎, 井口 元三, 林原 礼子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 別祖 香代, 和田 矩子, 山本 泰司

  本学保健管理センター「こころの健康相談」では、新規に初めて来所した人に診断分類を行い、ICD-10に基づき12種類に分類している。今回、2018年4月～2022年3月に新規に来所した学生860名の診断分類の年次推移について検討した。疾病域に該当しない正常範囲に分類された学生の割合は、2018年度が21.4%、2019年度27.1%、2020年度27.4%、2021年度36.0%であり、経年的に有意に増加していた。単極性うつ病に分類された割合は、2018年度14.3%、2019年度15.3%、2020年度16.4%、2021年度8.7%であり、2021年度は他の年度に比べて有意に低かった。発達障害に分類された割合は、2018年度6.7%、2019年度5.7%、2020年度5.5%、2021年度7.6%であり、コロナ禍の2019・2020年度に比べて2021年度は増加傾向にあった。

  (公社)全国大学保健管理協会, Mar. 2023, CAMPUS HEALTH, 60(1) (1), 269 - 271, Japanese


• Psychological Distress among University Staff before and during the COVID-19 Pandemic.

  Takaki Tanifuji, Kentaro Mouri, Yasuji Yamamoto, Shinsuke Aoyama

  (1) Background: The COVID-19 pandemic has distressed many populations worldwide, and since its beginning, many institutes have performed cross-sectional studies to assess mental health. We longitudinally examined psychological distress and depressive symptoms among university staff in Japan from 2019 to 2021, before and during the COVID-19 pandemic.; (2) Methods: Participants were teachers and hospital staff working at institutions related to Kobe University, who completed the Brief Job Stress Questionnaire (BJSQ) from 2019 to 2021. This study used the definition recommended by the guideline to identify high-stress. We analyzed the relationship between those who identified as having high-stress before versus during the COVID-19 pandemic using logistic regression analysis (adjusted for age, sex, and occupation).; (3) Results: Results showed that Stress Reaction scores increased slightly in 2020 and significantly in 2021. Time and other factors had a synergistic effect on mental health. The increase in Stress Reaction was significantly associated with females and nurses over the three years. Those with high-stress in 2019 had approximately twenty-fold odds ratios (OR) of having high-stress in 2020 and 2021.; (4) Conclusions: The long-term COVID-19 pandemic may disturb university staff's mental health. Those who originally experienced high levels of stress were vulnerable to the negative effects of the COVID-19 pandemic.

  Jan. 2023, International journal of environmental research and public health, 20(3) (3), English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Preventive effects of preoperative ramelteon on postoperative delirium in Asian elderly population: A randomized, double-blind, placebo-controlled trial, and a systematic review and meta-analysis.

  Takaki Tanifuji, Ikuo Otsuka, Satoshi Okazaki, Tadasu Horai, Ryuhei So, Kyoichi Shiroiwa, Kentaro Mouri, Motofumi Tanaka, Nobuko Ohmoto, Ichiro Sora, Midori Hirai, Takumi Fukumoto, Yonson Ku, Akitoyo Hishimoto

  Oct. 2022, Asian journal of psychiatry, 78, 103282 - 103282, English, International magazine


• コロナ禍におけるこころの健康相談新規来所者の診断分類の変化について

  近藤 泰子, 足立 祥, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 別祖 香代, 和田 矩子, 山本 泰司

  (公社)全国大学保健管理協会, Oct. 2022, 全国大学保健管理研究集会プログラム・抄録集, 60回, 89 - 89, Japanese


• 新型コロナウイルス感染症(COVID-19)による環境変化が教職員に与えた精神的ストレスの評価

  毛利 健太朗, 足立 祥, 飛松 崇子, 高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 長尾 伸子, 大崎 絵里子, 寺内 千春, 菅尾 有紀子, 別祖 香代, 和田 矩子, 藤平 和弘, 谷藤 貴紀, 青山 慎介, 山本 泰司

  (公社)全国大学保健管理協会, Oct. 2022, 全国大学保健管理研究集会プログラム・抄録集, 60回(1) (1), 46 - 46, Japanese


• Psychological symptoms and related risk factors among healthcare workers and medical students during the early phase of the COVID‐19 pandemic in Japan

  Takaki Tanifuji, Shinsuke Aoyama, Yutaka Shinko, Kentaro Mouri, Saehyeon Kim, Seimi Satomi‐Kobayashi, Masakazu Shinohara, Seiji Kawano, Ichiro Sora

  Wiley, Mar. 2022, Psychiatry and Clinical Neurosciences Reports, 1(1) (1)

  Scientific journal


• 長時間労働者面接指導による、働き方改革関連法施行前後の過重労働状況の比較検討

  藤平 和弘, 毛利 健太朗, 足立 祥, 飛松 崇子, 高橋 健太郎, 篠原 正和, 井口 元三, 山本 泰司

  (公社)日本産業衛生学会, Apr. 2021, 産業衛生学雑誌, 63(臨増) (臨増), 560 - 560, Japanese


• COVID-19対策を講じた上で施行した職員特殊健康診断・特定業務従事者健康診断

  飛松 崇子, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 家倉 宏子, 別祖 香代, 堀内 麻生, 板垣 季昭, 長谷川 太一, 毛利 健太朗, 高橋 健太郎, 藤平 和弘, 柴田 信雄, 山本 泰司

  COVID-19の拡大に伴い厚労省労働基準局長から職員健康診断は「本年度(令和2年)6月末まで延期して差し支えない」と通知された。しかし、兵庫県下で緊急事態宣言が解除された5月21日にはCOVID-19は収束していなかったことから、法令を遵守するためには感染対策を十分に講じた上で職員の特殊健康診断・特定業務従事者健康診断を行う必要性が生じた。本学では6月18日〜24日に大学保健管理センター2階とトレーニングルーム1階で同健診を実施し、入場者数を昨年の1/10以下に制限することで『密』を回避でき、健診終了後14日間に体調不良を訴えた者はいなかった。健診の実施方法について感染対策を中心に以下の項目別に報告した。1)検査項目。2)全体の感染対策。3)担当者の感染対策。4)全体の状況確認。5)感染対策の徹底を周知。6)体温測定・体調チェックおよび受検者入口。7)受付。8)トレーニングルーム1階の全体像。9)血圧測定、身長・体重測定。10)視力測定。11)内科診察。12)採血。13)検尿。14)胸部X線撮影。15)最終チェック。

  (公社)全国大学保健管理協会, Mar. 2021, CAMPUS HEALTH, 58(1) (1), 226 - 228, Japanese


• 職場におけるストレスチェックと職員一般健康診断の解析 心身の相互の影響を解析する

  鹿野 伸子, 藤平 和弘, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 楠田 康子, 林原 礼子, 近藤 泰子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 木田 綾子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  2019年度に神戸大学保健管理センターで職員一般健診とストレスチェックを受けた職員1150名を対象とし、健診各項目の値とストレスとの関連について検討した。健診項目は「BMI」「sBP」「dBP」「血糖」「LDL-C」「HDL-C」「中性脂肪」「尿酸」を調査対象とした。検討の結果、高ストレス判定とBMI異常との間に有意な関連が認められた。メンタルヘルスがフィジカルヘルスに与える影響について検討するため、ストレスチェックの領域A〜Dの各合計点数を説明変数とし、健診各項目を目的変数とするロジスティック回帰分析を行った結果、領域A合計と「HDL-C」との間に負の相関、「中性脂肪」「尿酸」との間に正の相関が認められた。フィジカルヘルスがメンタルヘルスに与える影響について検討するため。健診各項目を説明変数とし、高ストレス判定を目的変数とするロジスティック回帰分析を行った結果、有意な相関は認められなかった。

  (公社)全国大学保健管理協会, Mar. 2021, CAMPUS HEALTH, 58(1) (1), 396 - 398, Japanese


• 働き方改革関連法(改正労働基準法)施行による長時間労働状況の変化 本学における長時間労働者への面接指導について法令改正前後の比較

  藤平 和弘, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 木田 綾子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  2019年4月1日付の働き方改革関連法施行により労働基準法等も改正され、法定時間外労働時間が1ヵ月あたり100時間未満または2〜6ヵ月の平均で80時間以内という上限が設定され、違反者には罰則規定が設けられたが、医師などについては上限が設定されなかった。今回、本学における2016年4月〜2020年9月の長時間面接指導件数を半年期間毎に集計し、法令改正前後で比較した。結果、改正前は40.8件/半年、改正後は26.0件/半年で有意に減少していた。職種別にみると事務系と医療系は有意に減少し、海事系も減少していたが、医師は増加しており、医師の過重労働は法令改正後も改善されていないことが明らかになった。

  (公社)全国大学保健管理協会, Mar. 2021, CAMPUS HEALTH, 58(1) (1), 402 - 404, Japanese


• 職場におけるストレスチェックと職員一般健康診断の解析 心身の相互の影響を解析する

  鹿野 伸子, 藤平 和弘, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 楠田 康子, 林原 礼子, 近藤 泰子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 木田 綾子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2021, CAMPUS HEALTH, 58(1) (1), 396 - 398, Japanese


• 働き方改革関連法(改正労働基準法)施行による長時間労働状況の変化 本学における長時間労働者への面接指導について法令改正前後の比較

  藤平 和弘, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 木田 綾子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2021, CAMPUS HEALTH, 58(1) (1), 402 - 404, Japanese


• miR-19b is elevated in peripheral blood of schizophrenic patients and attenuates proliferation of hippocampal neural progenitor cells.

  Tadasu Horai, Shuken Boku, Satoshi Okazaki, Ikuo Otsuka, Woraphat Ratta-Apha, Kentaro Mouri, Naruhisa Yamaki, Takashi Hirata, Akitoyo Hishimoto

  MicroRNAs (miRNAs) have been investigated in neurodevelopmental and psychiatric disorders including schizophrenia (SZ). Previous studies showed miRNAs dysregulation in postmortem brain tissues and peripheral blood of SZ patients. These suggest that miRNAs may play a role in the pathophysiology of SZ and be a potential biomarker of SZ. Previous studies also showed that miRNAs regulated neurogenesis and that neurogenesis was involved in the pathophysiology of SZ. In addition, a recent study showed that miR-19a and 19b, enriched in neural progenitor cells (NPC) in adult hippocampus, were increased in human NPC derived from induced pluripotent stem cell derived from SZ patients. However, it remains unclear whether the levels of miR-19a and 19b are altered in peripheral blood of SZ patients and how miR-19a and 19b affects neurogenesis. To elucidate them, first we examined the levels of miR-19a and 19b in peripheral blood of SZ patients with quantitative RT-PCR and showed that the level of miR-19b, but not miR-19a, was significantly higher (miR-19a: p = 0.5733, miR-19b: p = 0.0038) in peripheral blood of SZ patients (N = 22) than that of healthy controls (N = 19). Next, we examined the involvement of miR-19b in proliferation and survival of mouse neonatal mice hippocampus-derived NPC with BrdU assay and TUNEL assay. The silencing of miR-19b significantly increased proliferation (N = 5, p = 0.0139), but not survival (N = 5, p = 0.9571), of neonatal mice hippocampus-derived NPC. These results suggest that the level of miR-19b in peripheral blood is a potential biomarker of schizophrenia and that the higher level of miR-19b may increase the vulnerability of SZ via attenuating proliferation of hippocampal NPC.

  Dec. 2020, Journal of psychiatric research, 131, 102 - 107, English, International magazine

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 新型インフルエンザから新型コロナへ 神戸大学「感冒様症状に係る届出制度」

  高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 谷口 真理子, 寺内 千春, 菅尾 有紀子, 有村 和代, 池上 峰子, 岡本 眞智子, 竹下 かおり, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Nov. 2020, 全国大学保健管理研究集会プログラム・抄録集, 58回, 63 - 63, Japanese


• 職場におけるストレスチェックと職員一般健康診断の解析 心身の相互の影響を解析する

  鹿野 伸子, 藤平 和弘, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 楠田 康子, 林原 礼子, 近藤 泰子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 井口 元三, 山本 泰司

  (公社)全国大学保健管理協会, Nov. 2020, 全国大学保健管理研究集会プログラム・抄録集, 58回, 106 - 106, Japanese


• 働き方改革関連法施行による労働状況の変化 長時間労働者面接指導の改正前後の比較

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 井口 元三, 毛利 健太朗, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 山本 泰司

  (公社)全国大学保健管理協会, Nov. 2020, 全国大学保健管理研究集会プログラム・抄録集, 58回, 106 - 106, Japanese


• 高齢労働者の再雇用就労における就業上の配慮・措置について 産業医の役割

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 井口 元三, 毛利 健太朗, 篠原 正和, 山本 泰司

  (一社)日本老年医学会, Jul. 2020, 日本老年医学会雑誌, 57(Suppl.) (Suppl.), 137 - 137, Japanese


• 本学における再雇用に係る就労判定について 就労判定の進め方と産業医の役割

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 井口 元三, 毛利 健太朗, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 大崎 絵里子, 有村 和代, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2020, CAMPUS HEALTH, 57(1) (1), 160 - 162, Japanese


• 神戸大学「麻疹風疹登録制度」 全学休校から始まった10年の軌跡

  高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 大崎 絵里子, 谷口 真理子, 寺内 千春, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 谷川 直子, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2020, CAMPUS HEALTH, 57(1) (1), 194 - 194, Japanese


• 本学における再雇用に係る就労判定について 就労判定の進め方と産業医の役割

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 井口 元三, 毛利 健太朗, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 大崎 絵里子, 寺内 千春, 谷口 真理子, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 家倉 宏子, 別祖 香代, 篠原 正和, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Sep. 2019, 全国大学保健管理研究集会プログラム・抄録集, 57回, 58 - 58, Japanese


• 神戸大学「麻疹風疹登録制度」 全学休校から始まった10年の軌跡

  高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 大崎 絵里子, 谷口 真理子, 寺内 千春, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 谷川 直子, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Sep. 2019, 全国大学保健管理研究集会プログラム・抄録集, 57回, 64 - 64, Japanese


• 男性アルコール依存症患者の骨密度低下に関する横断的研究

  蓬莱 政, 菱本 明豊, 大塚 郁夫, 新名 尚史, 岡崎 賢志, 毛利 健太朗, 朴 秀賢, 曽良 一郎

  (公社)日本精神神経学会, Jun. 2019, 精神神経学雑誌, (2019特別号) (2019特別号), S749 - S749, Japanese

  [Refereed]


• Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age.

  Hirata T, Otsuka I, Okazaki S, Mouri K, Horai T, Boku S, Takahashi M, Ueno Y, Sora I, Shirakawa O, Hishimoto A

  Jun. 2019, Psychiatry research, 278, 141 - 145

  [Refereed]


• UPIを用い呼び出し面接を行った学生の経過とその検討

  毛利健太朗, Yamamoto Yasuji, Baba Hisamitsu

  本学(大学)保健管理センターでは毎年、新入学生健康診断時に精神的健康調査であるUPI(University Personality Inventory)を施行し、「全60項目中31項目以上チェックした学生」「希死念慮の項目(項目25)にチェックした学生」「呼び出し希望の項目をチェックしている学生」を「呼び出し対象者」として呼出面接を行っており、今回、呼出面接を行った学生の4年間の経過を、呼出対象となった平成26年度新入生155名のうち、当センターから連絡し、相談を希望し面接を行った43名を対象に検討した。その結果、卒業まで来所したケースは4名で、診断はうつ病1名、不安障害2名、発達障害1名であった。今回の呼び出し対象者では4年間での自殺既遂者はいなかったが、希死念慮の項目(項目25)をチェックしている学生のスクリーニングは重要であると考えられた。

  (公社)全国大学保健管理協会, Mar. 2019, CAMPUS HEALTH, 56(1) (1), 331 - 333, Japanese


• Epigenetic clock analysis of blood samples from Japanese schizophrenia patients.

  Satoshi Okazaki, Ikuo Otsuka, Shusuke Numata, Tadasu Horai, Kentaro Mouri, Shuken Boku, Tetsuro Ohmori, Ichiro Sora, Akitoyo Hishimoto

  The accelerated aging hypothesis of schizophrenia (SCZ) has been proposed. DNA methylation profiles were developed for determining "epigenetic age." Here, we assessed intrinsic and extrinsic epigenetic age acceleration (IEAA and EEAA, respectively) in SCZ. We examined two independent cohorts of Japanese ancestry. The first cohort consisted of 80 patients with SCZ under long-term or repeated hospitalization and 40 controls, with the economical DNA pooling technique. The second cohort consisted of 24 medication-free patients with SCZ and 23 controls. Blood of SCZ subjects exhibited decreased EEAA in the first cohort (p = 0.0162), but not in the second cohort. IEAA did not differ in either cohort. We performed replication analyses using publicly available datasets from European ancestry (three blood and one brain datasets). One blood dataset showed increased EEAA in SCZ (p = 0.0228). Overall, our results provide evidence for decreased EEAA in SCZ associated with hospitalization in the Japanese population.

  Feb. 2019, NPJ schizophrenia, 5(1) (1), 4 - 4, English, International magazine

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis.

  Naruhisa Yamaki, Ikuo Otsuka, Shusuke Numata, Masaya Yanagi, Kentaro Mouri, Satoshi Okazaki, Shuken Boku, Tadasu Horai, Tetsuro Ohmori, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto

  Numerous evidence indicated mitochondrial abnormalities in the pathophysiology of bipolar disorder (BD); however, it remains unclear whether aberrant mitochondrial DNA (mtDNA) copy number (cn) occur in BD due to the conflicting results in previous studies. Here, peripheral blood mtDNAcn in 69 BD patients and 54 controls were analysed via qPCR. BD patients had significantly lower mtDNAcn compared to controls (regardless of their BD type [BD I or II]). Meta-analysis for all previous BD-mtDNAcn studies combining our results with previously published studies failed to identify any significant association. Meanwhile, Asian-specific meta-analysis remarkably revealed lower mtDNAcn in BD patients.

  Nov. 2018, Psychiatry research, 269, 115 - 117, English, International magazine

  [Refereed]

  Scientific journal


• A cross-sectional study exploring useful indicators for low bone mineral density in male alcoholic patients.

  Horai T, Hishimoto A, Otsuka I, SO T, Mouri K, Shimmyo N, Boku S, Okishio N, SORA ICHIRO

  Background: Alcohol dependence induces low bone mineral density (BMD), predicting osteoporosis, while low and moderate alcohol consumption may even increase BMD. In recent years, undercarboxylated osteocalcin (ucOC) and tartrate-resistant acid phosphatase-5b (TRACP-5b), bone turnover markers, have gained special interest as useful indicators of low BMD. However, it remains unclear whether other alcohol-related variables (eg, duration of abstinence and continuous drinking) are linked to aberrant BMD. In addition, no previous study has investigated whether ucOC or TRACP-5b is clinically useful to predict low BMD not only in the general population, but also in alcohol-dependent subjects. Patients and methods: We recruited 275 male alcohol-dependent subjects and collected information about their drinking habits, comorbid diseases, smoking history and walking exercise behavior. BMD in each subject was determined by ultrasonography. Serum liver enzymes (AST, ALT, ALP, ChE, γ-GTP and LDH), ucOC and TRACP-5b were measured in all subjects. T-scores were calculated according to BMD for all subjects. Results: The mean T-scores of our subjects were negatively shifted compared to the general population (-0.75±1.36 SD). We divided our subjects into a normal BMD group (n=137) and a low BMD group (n=138) according to their T-scores (T-score ≥-1 SD, normal BMD; T-score <-1 SD, low BMD). Multivariate logistic regression analysis showed that body mass index (BMI) was negatively associated with low BMD (95% CI: 0.75-0.90). By contrast, long abstinence period (95% CI: 1.40-4.21), smoking (95% CI: 1.30-5.56), hypertension (95% CI: 1.04-3.76), lactate dehydrogenase (LDH) (95% CI: 1.00-1.01) and ucOC (95% CI: 1.04-1.22) were positively associated with low BMD. Conclusion: In alcohol-dependent males, smoking habits and higher ucOC are associated with low BMD. Our study suggests that smoking cessation may prevent lower BMD, and ucOC may predict lower BMD in alcohol-dependent individuals.

  Feb. 2018, Neuropsychiatr Dis Treat, 14, 663 - 669, English, International magazine

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• 自殺既遂者におけるテロメア異常短縮(Shorter telomere length in suicide completers)

  大塚 郁夫, 菱本 明豊, 泉 剛, 朴 秀賢, 木村 敦, 張 園, 毛利 健太朗, 岡崎 賢志, 高橋 玄倫, 上野 易弘, 白川 治, 曽良 一郎

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 156 - 156, English

  Research society


• 視神経膠腫治療の経過中に幻覚妄想、精神運動興奮を認めた下垂体機能低下症の1例

  内田杏子, MATSUYAMA KENICHI, MOURI KENTARO, AOYAMA SHINSUKE, HISHIMOTO AKITOYO, SORA ICHIRO

  (公社)日本精神神経学会, Sep. 2017, 精神神経学雑誌, 119(9) (9), 702 - 702, Japanese

  Scientific journal


• Aberrant telomere length and mitochondrial DNA copy number in suicide completers

  Ikuo Otsuka, Takeshi Izumi, Shuken Boku, Atsushi Kimura, Yuan Zhang, Kentaro Mouri, Satoshi Okazaki, Kyoichi Shiroiwa, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto

  Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no study has examined whether aberrant TL or mtDNAcn occur in completed suicide, one of the most serious outcomes of mental illnesses. TL and mtDNAcn in post-mortem samples from 528 suicide completers without severe physical illness (508 peripheral bloods; 20 brains) and 560 samples from control subjects (peripheral bloods from 535 healthy individuals; 25 post-mortem brains) were analysed by quantitative polymerase chain reaction. Suicide completers had significantly shorter TL and higher mtDNAcn of peripheral bloods with sex/age-dependent differences (shorter TL was more remarkably in female/young suicides; higher mtDNAcn more so in male/elderly suicides). The normal age-related decline of TL and mtDNAcn were significantly altered in suicide completers. Furthermore, shorter TL and lower mtDNAcn of post-mortem prefrontal cortex were seen in suicide completers compared to controls. This study shows the first association of aberrant telomeres and mtDNA content with suicide completion. Our results indicate that further research on telomere shortening and mitochondrial dysfunction may help elucidate the molecular underpinnings of suicide-related pathophysiology.

  NATURE PUBLISHING GROUP, Jun. 2017, SCIENTIFIC REPORTS, 7(1) (1), 3176, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association study of MIF promoter polymorphisms with suicide completers in the Japanese population.

  Shimmyo N, Hishimoto A, Otsuka I, Okazaki S, Boku S, Mouri K, Horai T, Takahashi M, Ueno Y, Shirakawa O, Sora I

  2017, Neuropsychiatric disease and treatment, 13, 899 - 908

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• A ssociation study of MIF promoter polymorphisms with suicide completers in the Japanese population

  Naofumi Shimmyo, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Kentaro Mouri, Tadasu Horai, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora

  Background: Numerous studies suggest that inflammation plays a key role in suicidal behavior. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has received increasing attention in depression research. However, no study has investigated whether MIF has genetic involvement in completed suicide. In this study, we sought to explore the relationship between two functional polymorphisms on the MIF gene promoter (MIF-794CATT(5-8) microsatellite and MIF-173G/C single-nucleotide polymorphism [ SNP]) and completed suicide by using one of the largest samples of suicide completers ever reported. Methods: The subjects comprised 602 suicide completers and 728 healthy controls. We genotyped MIF-794CATT(5-8) microsatellite by polymerase chain reaction-based size discrimination assay and MIF-173G/C SNP by TaqMan((R)) SNP genotyping assay. The allele-, genotype-, or haplotype-based association analyses between the suicide completers and the controls were carried out with the chi(2) test, the Cochran-Armitage trend test, or Fisher's exact test. Results: Analyses of allele or genotype frequency distributions of the polymorphisms studied here did not reveal any significant differences between the suicide completers and the controls. Haplotype analysis also revealed no association with completed suicide. Conclusion: To our knowledge, this is the first study that has examined the genetic association between MIF and completed suicide. Our results suggest that the effects of MIF-794CATT(5-8) microsatellite and MIF-173G/C SNP on the MIF gene promoter might not contribute to the genetic risk of completed suicide in the Japanese population.

  DOVE MEDICAL PRESS LTD, 2017, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 13, 899 - 908, English

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• The cell cycle-related genes as biomarkers for schizophrenia

  Satoshi Okazaki, Shuken Boku, Ikuo Otsuka, Kentaro Mouri, Shinsuke Aoyama, Kyoichi Shiroiwa, Ichiro Sora, Aiko Fujita, Yutaka Shirai, Osamu Shirakawa, Masahiro Kokai, Akitoyo Hishimoto

  Background: Recent studies suggest that genomic abnormalities such as single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) may elevate the risk of schizophrenia. Such genomic abnormalities often occur during chromosomal DNA replication in the S phase of cell cycle. In addition, several studies showed that abnormal expressions of several cell cycle-related genes are associated with schizophrenia. Therefore, here we compared mRNA expression levels of cell cycle-related genes in peripheral blood cells between patients with schizophrenia and healthy controls. Method: mRNA expression levels of cell cycle-related genes in peripheral blood cells from patients with schizophrenia and healthy controls were measured with quantitative reverse transcription polymerase chain reaction (Q-RT-PCR). The discovery, replication and intervention studies with Q-RT-PCR were performed as follows: discovery (40 cases and 20 controls), replication (82 cases and 74 controls) and intervention (22 cases and 18 controls). Result: Nine genes were identified in the discovery and replication stages as schizophrenia-associated genes. Moreover, the combination of mRNA expression levels of CDK4, MCM7 and POLD4 was identified as a potential biomarker for schizophrenia with multivariate logistic regression analysis. The intervention stage revealed that the mRNA expression levels of these three genes were significantly decreased in the acute state of schizophrenia, and CDK4 was significantly recovered in the remission state of schizophrenia. Conclusion: The combination of mRNA expression levels of three cell cycle-related genes such as CDK4, MCM7 and POLD4 is expected to be a candidate for useful biomarkers for schizophrenia. Especially, the mRNA expression changes of CDK4 may be potential as both trait and state markers for schizophrenia. (C) 2016 Elsevier Inc. All rights reserved.

  PERGAMON-ELSEVIER SCIENCE LTD, Oct. 2016, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 70, 85 - 91, English

  [Refereed]

  Scientific journal


• 男性アルコール依存症患者における骨密度減少のリスクファクターに関する横断研究(The risk factors of low bone mineral density in male alcoholic patients: cross-sectional study)(英語)

  蓬莱政, 菱本明豊, 毛利健太朗, 朴秀賢, 江口典臣, 新名尚史, 木村敦, Ichiro Sora

  (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集 46回, 46回, 223 - 223, Japanese

  [Refereed]

  Scientific journal


• ニコチン依存におけるCDH13の役割 マウス神経前駆細胞と統合失調症臨床サンプルを用いた解析(Possible role of CDH13 in nicotine dependence: Investigations on mouse neural progenitors and schizophrenia patients)(英語)

  大塚郁夫, 菱本明豊, 朴秀賢, 岡崎賢志, 毛利健太朗, Ichiro Sora

  (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集 46回, 46回, 220 - 220, Japanese

  [Refereed]

  Scientific journal


• KIF17の脳内タンパク減少とミスセンス変異は統合失調症と関連する(A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia)(英語)

  菱本明豊, 毛利健太朗, ラッタアッパ・ワラパット, 朴秀賢, Ichiro Sora

  (一社)日本神経精神薬理学会, Jul. 2016, 日本神経精神薬理学会年会プログラム・抄録集 46回, 46回, 210 - 210, Japanese

  [Refereed]

  Scientific journal


• The serum level of NX-DCP-R, but not DCP, is not increased in alcoholic liver disease without hepatocellular carcinoma.

  Masaya Saito, Yoshihiko Yano, Hirotaka Hirano, Kenji Momose, Kentaro Mouri, Akitoyo Hishimoto, Masaru Yoshida, Takeshi Azuma

  BACKGROUND AND AIM: Alcoholic liver disease (ALD) is the most common cause of hepatocellular carcinoma (HCC) worldwide. Des-gamma-carboxy prothrombin (DCP) is elevated in many patients with HCC, but also in severe alcoholics without HCC. We aimed to clarify whether the DCP/NX-DCP ratio (NX-DCP-R) could have a high specificity in ALD patients without HCC. METHODS: We performed a prospective cohort study on a total of 703 consecutive outpatients of liver diseases including severe alcoholics and healthy volunteers, who underwent blood biochemical examinations at Kobe University Hospital. Serum DCP was measured by electrochemiluminescence immunoassay (ECLIA) using a monoclonal antibody, MU-3. A novel parameter, serum NX-DCP, which represents predominantly DCP caused by reduced vitamin K availability, was also measured by ECLIA using monoclonal antibodies P-16 and P-11. The diagnostic accuracy of DCP and NX-DCP-R in patients with and without excessive alcohol intake was statistically examined. RESULTS: DCP was significantly higher in alcoholics than in non-alcoholics (p= 0.005), whereas the NX-DCP-R did not differ between alcoholics and non-alcoholics (p= 0.375). DCP was significantly increased in the serum of each patient with alcoholic hepatitis and alcoholic cirrhosis (p< 0.05), whereas the NX-DCP-R was not increased (p> 0.05). CONCLUSIONS: NX-DCP-R, but not DCP, was not increased in alcoholics without HCC. As for negative screening for HCC, the specificity of the NX-DCP-R in alcoholics without HCC was better than that of DCP in alcoholics without HCC, and so could be a useful negative screening tool for HCC in millions of alcoholics worldwide.

  2016, Cancer biomarkers : section A of Disease markers, 16(1) (1), 171 - 80, English, International magazine

  Scientific journal


• A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia

  Woraphat Ratta-apha, Kentaro Mouri, Shuken Boku, Hiroki Ishiguro, Satoshi Okazaki, Ikuo Otsuka, Ichiro Sora, Tadao Arinami, Osamu Shirakawa, Akitoyo Hishimoto

  It has been shown that the dysfunction of N-methyl-D-asparate (NMDA) receptors-mediated neurotransmission plays a role in the pathophysiblogy of schizophrenia. Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia. The kinesin superfamily motor protein 17 (KIF17) is known as a transporter of NR2B.Previous studies showed that a structural variant of KIF17 gene is associated with a schizophrenic phenotype. Therefore, here we investigated KIF17 levels in postmortem prefrontal cortex in schizophrenia and the association of a missense polymorphism (Ile341Val) in KIF17 with schizophrenia. The protein expression of KIF17 in schizophrenic postmortem brains was significantly lower than that in controls. Next, the association of missense polymorphisms (rs631375, rs13375609, rs522496 and rs2296225) of KIF17 gene in 567 schizophrenia and 710 healthy subjects was examined. Both genotypic distribution and allelic frequency of rs2296225 polymorphism were significantly different between the chronic schizophrenia subjects and controls. However, our findings described above were not replicated with the independent subjects (555 schizophrenia and 814 healthy controls). Furthermore, the two alleles of rs2296225 polymorphism did not affect the mRNA expression of KIF17. These results suggest that the dysfunction of KIF17 might be involved in the pathophysiology of schizophrenia. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

  ELSEVIER IRELAND LTD, Dec. 2015, PSYCHIATRY RESEARCH, 230(2) (2), 424 - 429, English

  [Refereed]

  Scientific journal


• Association analysis of the HLA-DRB1*01 and HLA-DRB1*04 with schizophrenia by tag SNP genotyping in the Japanese population.

  Ratta-apha W, Boku S, Mouri K, Okazaki S, Otsuka I, Watanabe Y, Nunokawa A, Someya T, Shirakawa O, Sora I, Hishimoto A

  Sep. 2015, Psychiatry research, 229(1-2) (1-2), 627 - 628

  [Refereed]


• 統合失調症における細胞周期関連遺伝子に着目した3段階mRNA発現解析(A three-stage mRNA expression study to identify cell cycle-related genes associated with schizophrenia)(英語)

  岡崎賢志, Hishimoto Akitoyo, 朴秀賢, 毛利健太朗, 白岩恭一, 大塚郁夫, 白井豊, 藤田愛子, 白川治, 湖海正尋, Ichiro Sora

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集37回・45回, 37回・45回, 172 - 172, Japanese

  Symposium


• 統合失調症におけるCadherin13遺伝子多型解析(Association analysis of the Cadherin 13 gene with schizophrenia in the Japanese population)(英語)

  大塚郁夫, 渡部雄一郎, Hishimoto Akitoyo, 朴秀賢, 毛利健太朗, 白岩恭一, 岡崎賢志, 布川綾子, 白川治, 染矢俊幸, Ichiro Sora

  Sep. 2015, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集37回・45回, 201, Japanese

  Symposium


• 危険ドラッグの臨床症状への影響および遺伝子多型との関連の検討

  岡崎賢志, Hishimoto Akitoyo, 朴秀賢, 毛利健太朗, 竹村幸洋, 麻生克郎, 山本訓也, Ichiro Sora

  (一社)日本アルコール・アディクション医学会, Aug. 2015, 日本アルコール・薬物医学会雑誌, 50(4号) (4号), 230 - 230, Japanese

  Research society


• 血清マイクロRNAの定性的解析による統合失調症の診断・病態マーカーの探索

  Hishimoto Akitoyo, 毛利健太朗, 朴秀賢, 岡崎賢志, 白岩恭一, Ichiro Sora

  (公財)先進医薬研究振興財団, Mar. 2015, 先進医薬研究振興財団研究成果報告集, 2014年度(2014年度) (2014年度), 24 - 25, Japanese

  Research society


• 反復性うつ病の入院治療中に多飲水行動を呈した1例

  小林 明美, 石丸 綾子, 笹田 徹, 白岩 恭一, 毛利 健太朗, 山本 泰司, 菱本 明豊, 田中 究, Ichiro Sora

  Feb. 2015, 精神神経学雑誌, 117(2号) (2号), 161, Japanese

  Research society


• Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population

  Ikuo Otsuka, Yuichiro Watanabe, Akitoyo Hishimoto, Shuken Boku, Kentaro Mouri, Kyoichi Shiroiwa, Satoshi Okazaki, Ayako Nunokawa, Osamu Shirakawa, Toshiyuki Someya, Ichiro Sora

  Background: Cadherin13 (CDH13) is a glycosylphosphatidylinositol-anchored cell adhesion molecule that plays a crucial role in morphogenesis and the maintenance of neuronal circuitry. CDH13 has been implicated in the susceptibility to a variety of psychiatric diseases. A recent genome-wide association study using Danish samples showed, for the first time, the involvement of a single nucleotide polymorphism (SNP) of CDH13 (intronic SNP rs8057927) in schizophrenia. Here, we investigated the association between other SNPs of CDH13 and schizophrenia and tried to replicate the association for the SNP of rs8057927, in the Japanese population. Methods: Using TaqMan (R) SNP genotyping assays, five tag SNPs (rs12925602, rs7193788, rs736719, rs6565051, and rs7204454) in the promoter region of CDH13 were examined for their association with schizophrenia in two independent samples. The first sample comprised 665 patients and 760 controls, and the second sample comprised 677 patients and 667 controls. One tag SNP for rs8057927 was also examined for the association with schizophrenia in the first sample set. Results: A GACAG haplotype of the five SNPs in the promoter region of CDH13 was significantly associated with schizophrenia in the first sample set (P=0.016 and corrected P=0.098). A combined analysis of the GACAG haplotype with the second sample set enhanced the significance (P=0.0026 and corrected P=0.021). We found no association between rs8057927 and schizophrenia in the first sample set. Conclusion: Our results suggest that CDH13 may contribute to the genetic risk of schizophrenia. Further replication on the association of CDH13 with schizophrenia and functional studies are required to confirm the current findings.

  DOVE MEDICAL PRESS LTD, 2015, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 11, 1381 - 1393, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population.

  Otsuka I, Watanabe Y, Hishimoto A, Boku S, Mouri K, Shiroiwa K, Okazaki S, Nunokawa A, Shirakawa O, Someya T, Sora I

  2015, Neuropsychiatric disease and treatment, 11, 1381 - 1393

  [Refereed]

  Link to Kobe Univ. Repository (Kernel)


• 神戸大学医学部附属病院におけるblonanserinの投与状況について

  白岩 恭一, 毛利 健太朗, 笹田 徹, 大塚 郁夫, 大本 暢子, Hishimoto Akitoyo, Ichiro Sora

  Nov. 2014, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集24回・44回, 174, Japanese

  [Refereed]

  Symposium


• 慢性疼痛に対しduloxetineが奏効した4症例の検討

  大塚 郁夫, 白岩 恭一, 毛利 健太朗, 笹田 徹, Hishimoto Akitoyo, Ichiro Sora

  Aug. 2014, 臨床精神薬理, 17(8号) (8号), 1151 - 1156, Japanese

  [Refereed]

  Scientific journal


• Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia

  Satoshi Okazaki, Yuichiro Watanabe, Akitoyo Hishimoto, Toru Sasada, Kentaro Mouri, Kyoichi Shiroiwa, Noriomi Eguchi, Woraphat Ratta-Apha, Ikuo Otsuka, Ayako Nunokawa, Naoshi Kaneko, Masako Shibuya, Toshiyuki Someya, Osamu Shirakawa, Ichiro Sora

  Background: Genome-wide association studies (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with multifactorial diseases, such as schizophrenia, are significantly more likely to be associated with expression quantitative trait loci (eQTL). It was recently suggested that an immune system imbalance plays an important role in the pathogenesis of schizophrenia. Interleukin-19 is a novel cytokine that may play multiple roles in immune regulation and various diseases. Method: We selected eight tag SNPs in the eQTL of the IL-19 gene. Seven of the SNPs are putative cis-acting SNPs. Then, we conducted a case-control study using two independent samples. The first sample comprised 567 schizophrenia patients and 710 controls, and the second sample comprised 677 schizophrenia patients and 667 controls. Result: We identified the TGAA haplotype as being significantly associated with schizophrenia (p = 0.0036 and corrected p = 0.0264), although a combined analysis of the TGAA haplotype with the replication samples exhibited a nominally significant difference (p = 0.022 and corrected p = 0.235). Conclusions: These results suggest that the IL-19 gene might slightly contribute to the genetic risk of schizophrenia. Thus, further research on the association of eQTL SNPs with schizophrenia is warranted. (C) 2013 Elsevier Inc. All rights reserved.

  PERGAMON-ELSEVIER SCIENCE LTD, Apr. 2014, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 50, 151 - 156, English

  [Refereed]

  Scientific journal


• A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population

  Yuichiro Watanabe, Masako Shibuya, Ayako Nunokawa, Naoshi Kaneko, Hirofumi Igeta, Jun Egawa, Toshiyuki Someya, Akitoyo Hishimoto, Kentaro Mouri, Ichiro Sora

  ELSEVIER IRELAND LTD, Mar. 2014, PSYCHIATRY RESEARCH, 215(3) (3), 801 - 802, English

  [Refereed]

  Scientific journal


• 我々はいかにして彼を同意無能力と判定したか 慢性腎臓病を伴う統合失調症患者の透析導入検討に際して

  宋 龍平, 毛利 健太郎, 田宮 裕子, 田中 究, Ichiro Sora

  Jan. 2014, 精神神経学雑誌, 116(1号) (1号), 91, Japanese

  Symposium


• Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers

  Woraphat Ratta-apha, Akitoyo Hishimoto, Kentaro Mouri, Kyoichi Shiroiwa, Toru Sasada, Masakuni Yoshida, Satoshi Okazaki, Irwan Supriyanto, Migiwa Asano, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora

  The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISCI) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISCI was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISCI with suicide. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

  ELSEVIER IRELAND LTD, Jan. 2014, PSYCHIATRY RESEARCH, 215(1) (1), 249 - 251, English

  [Refereed]

  Scientific journal


• Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain

  Woraphat Ratta-apha, Akitoyo Hishimoto, Kentaro Mouri, Kyoichi Shiroiwa, Toru Sasada, Masakuni Yoshida, Irwan Supriyanto, Yasuhiro Ueno, Migiwa Asano, Osamu Shirakawa, Hideru Togashi, Yoshimi Takai, Ichiro Sora

  The Disrupted-in-Schizophrenia 1 (DISC1) gene plays a role in the regulation of neural development. Previous evidence from genetic association and biological studies implicates the DISC1 gene as having a role in the pathophysiology of schizophrenia. In the present study, we explored the association between DISCI missense mutation rs821616 (Ser704Cys) single nucleotide polymorphism (SNP) and four other SNPs (rs1772702, rs1754603, rs821621, rs821624) in the related haplotype block and schizophrenia in the Japanese population. We could not find a significant association of selected SNPs with schizophrenia after correction for multiple testing. We performed a meta-analysis of the Ser704Cys variant in schizophrenia using data from the present study and five previous Japanese population studies, and found no association with schizophrenia. We also examined DISCI immunoreactivity in postmortem prefrontal cortex specimens of schizophrenia patients compared to control samples. The immunoreactivity revealed a significant decrease of DISCI protein expression in the schizophrenia samples after ruling out potential confounding factors. However, the Ser704Cys variant did not show effects on DISCI immunoreactivity. These results provide evidence that this functional genetic variation of DISC1 do not underlie the pathophysiology of schizophrenia in the Japanese population. (c) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

  ELSEVIER IRELAND LTD, Dec. 2013, NEUROSCIENCE RESEARCH, 77(4) (4), 222 - 227, English

  [Refereed]

  Scientific journal


• 慢性疼痛へのセロトニン・ノルアドレナリン再取り込み阻害薬デュロキセチンの有効性

  大塚 郁夫, 白岩 恭一, 菱本 明豊, 毛利 健太朗, 笹田 徹, 曽良 一郎

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 170 - 170, Japanese


• 精神病症状を伴う産後うつ病に高用量のquetiapineが奏効した1例

  山木 愛久, Mouri Kentaro, Shiroiwa Kyoichi, 田中 究, Hishimoto Akitoyo

  Oct. 2013, 臨床精神薬理, 16(10号) (10号), 1505 - 1509, Japanese

  [Refereed]

  Scientific journal


• 心臓血管外科手術患者における術前のStatin使用と術後せん妄の関連についての検討

  新光 穣, 松石 邦隆, 福武 将映, Mouri Kentaro, 井上 和音, 小山 忠明, 伊藤 聡子, 北村 登

  Patients often develop delirium after cardiovascular surgery. To determine the association of the preoperative use of statins with a reduced incidence of post-operative delirium, we retrospectively collected data from 324 patients who underwent cardiac and aortic surgery at our hospital from July 2011 through June 2012. The incidence of postoperative delirium significantly decreased in patients who were administered statins preoperatively. Based on the data collected, emergency surgeries, advanced age, and longer operation time were further indicated predictors of postoperative delirium. These results indicate that preoperative administration of statins decreases the risk of delirium after cardiac and aortic surgery, by possibly protecting the central nervous system.

  Japanese Society of General Hospital Psychiatry, Jan. 2013, 総合病院精神医学, 25(1号) (1号), 49 - 54, Japanese

  [Refereed]

  Scientific journal


• A missense mutation in the ITGA8 gene, a cell adhesion molecule gene, is associated with schizophrenia in Japanese female patients

  Irwan Supriyanto, Yuichiro Watanabe, Kentaro Mouri, Kyoichi Shiroiwa, Woraphat Ratta-Apha, Masakuni Yoshida, Genki Tamiya, Toru Sasada, Noriomi Eguchi, Kenji Okazaki, Osamu Shirakawa, Toshiyuki Someya, Akitoyo Hishimoto

  Background: Cell adhesion molecules (CAMs) play pivotal role in the development of the central nervous system (CNS) and have also been reported to play role in the pathophysiology of schizophrenia. Missense mutations in the CAMs genes might alter the binding of their ligands, increasing the vulnerability to develop schizophrenia. Methods: We selected 15 missense mutations in the CAMs genes of the CNS reported in the Kyoto Encyclopedia of Genes and Genomes (KEGG) and examined the association between these mutations and schizophrenia in 278 patients and 284 control subjects (first batch). We also genotyped the positive single nucleotide polymorphisms (SNPs) in 567 patients and 710 control subjects (second batch) and in 635 patients and 639 control subjects (replication samples). Results: Genotypic and allelic distributions of rs2298033 in the ITGA8 gene between the schizophrenia and control groups were significantly different in the first batch (p = 0.005 and 0.007, respectively). Gender-based analysis revealed that the allelic and genotypic distributions of rs2298033 in the ITGA8 were significantly different between the schizophrenia and control groups among females in both batches (p = 0.010, 0.011 and 0.0086, 0.010, respectively) but not among males. Combine analysis of rs2298033 with the replication samples revealed a more significant differences (p = 0.0032; 0.0035 in the overall subjects and p = 0.0024; 0.0025 in the female subjects, respectively). The significant differences for rs2802808 of the NFASC gene were only observed in the female subgroup of the first batch. Conclusion: These results suggest that the ITGA8 gene might have gender-specific roles in the development of schizophrenia. Further replication and functional studies are required to confirm these findings. (c) 2012 Elsevier Inc. All rights reserved.

  PERGAMON-ELSEVIER SCIENCE LTD, Jan. 2013, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 40, 347 - 352, English

  [Refereed]

  Scientific journal


• Haplotypes in the expression quantitative trait locus of interleukin-1 beta gene are associated with schizophrenia

  Masakuni Yoshida, Kyoichi Shiroiwa, Kentaro Mouri, Hiroki Ishiguro, Irwan Supriyanto, Woraphat Ratta-Apha, Noriomi Eguchi, Satoshi Okazaki, Toru Sasada, Masaaki Fukutake, Takeshi Hashimoto, Toshiya Inada, Tadao Arinami, Osamu Shirakawa, Akitoyo Hishimoto

  Recent genome-wide association study (GWAS) and gene expression analyses have revealed that single nucleotide polymorphisms (SNPs) associated with complex diseases such as schizophrenia are significantly more likely to be associated with expression quantitative trait loci (eQTL). The interleukin-1 beta (IL1B) gene has been strongly implicated in the susceptibility to schizophrenia. In order to test this association, we selected five tag SNPs in the eQTL of the IL1B gene and conducted a case-control study using two independent samples. The first sample comprised 528 schizophrenic patients and 709 controls and the second sample comprised 576 schizophrenic patients and 768 controls. We identified two SNPs and several haplotypes as being significantly associated with schizophrenia. Previous reports indicated that one major haplotype that was protective against schizophrenia reduced IL1B transcription, while two risk haplotypes for schizophrenia enhanced IL1B transcription. Therefore, we measured IL1B mRNA expression in PAXgene-stabilized whole blood from 40 schizophrenic patients and 40 controls to explore the possibility of using five tag SNPs as schizophrenic trait markers. A multiple regression analysis taking confounding factors into account revealed that the T allele of rs4848306 SNP, which is a protective allele for schizophrenia, predicted reduced change in IL1B mRNA expression, regardless of phenotype. Our results appear to support the previous hypothesis that IL1B contributes to the genetic risk of schizophrenia and warrant further research on the association of eQTL SNPs with schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

  ELSEVIER SCIENCE BV, Sep. 2012, SCHIZOPHRENIA RESEARCH, 140(1-3) (1-3), 185 - 191, English

  [Refereed]

  Scientific journal


• Psychological impact of the pandemic (H1N1) 2009 on general hospital workers in Kobe

  Kunitaka Matsuishi, Ayako Kawazoe, Hissei Imai, Atsushi Ito, Kentaro Mouri, Noboru Kitamura, Keiko Miyake, Koichi Mino, Masanori Isobe, Shizuo Takamiya, Hidefumi Hitokoto, Tatsuo Mita

  Aims: In order for hospitals to work efficiently in a pandemic, it is important to know how a pandemic affects the hospital staff. The aim of the present study was to investigate the psychological impact of the pandemic (H1N1) 2009 on hospital workers and how it was affected by the characteristics of the hospital, gender, age, job and work environment. Methods: In late June 2009, soon after the pandemic had ended in Kobe city, Japan, a questionnaire was distributed consisting of questions on sociodemographic characteristics, 19 stress-related questions and the Impact of Event Scale (IES) to all 3635 employees at three core general hospitals in Kobe. Exploratory factor analysis was applied to the 19 stress-related questions, and this produced four factors for evaluation (anxiety about infection, exhaustion, workload, and feeling of being protected). Multiple regression models were used to evaluate the association of personal characteristics with each score of the four factors and the IES. Results: Valid answers were received from 1625 employees. Workers at a hospital with intense liaison psychiatric services felt less psychological impact. Workers at a hospital that provided staff with information about the pandemic less frequently, felt unprotected. Workers in work environments that had a high risk of infection felt more anxious and more exhausted. The total IES score was higher in workers in high-risk work environments. Conclusions: It is important for hospitals to protect hospital workers during a pandemic and to rapidly share information about the pandemic. Liaison psychiatric services can help to reduce the impact of the pandemic on hospital workers.

  WILEY-BLACKWELL, Jun. 2012, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 66(4) (4), 353 - 360, English

  [Refereed]

  Scientific journal


• Superficial siderosis of the central nervous system presenting with hallucination and delusion: a case report.

  Hissei Imai, Kunitaka Matsuishi, Kentaro Mouri, Atsushi Ito, Noboru Kitamura, Naoki Nishino

  Jun. 2011, Psychiatry and clinical neurosciences, 65(4) (4), 395 - 6, English, International magazine


• Factors associated with motivation and hesitation to work among health professionals during a public crisis: a cross sectional study of hospital workers in Japan during the pandemic (H1N1) 2009

  Hissei Imai, Kunitaka Matsuishi, Atsushi Ito, Kentaro Mouri, Noboru Kitamura, Keiko Akimoto, Koichi Mino, Ayako Kawazoe, Masanori Isobe, Shizuo Takamiya, Tatsuo Mita

  Background: The professionalism of hospital workers in Japan was challenged by the pandemic (H1N1) 2009. To maintain hospital function under critical situations such as a pandemic, it is important to understand the factors that increase and decrease the willingness to work. Previous hospital-based studies have examined this question using hypothetical events, but so far it has not been examined in an actual pandemic. Here, we surveyed the factors that influenced the motivation and hesitation of hospital workers to work in Japan soon after the pandemic (H1N1) 2009. Methods: Self-administered anonymous questionnaires about demographic character and stress factors were distributed to all 3635 employees at three core hospitals in Kobe city, Japan and were collected from June to July, 2009, about one month after the pandemic (H1N1) in Japan. Results: Of a total of 3635 questionnaires distributed, 1693 (46.7%) valid questionnaires were received. 28.4% (N = 481) of workers had strong motivation and 14.7% (N = 249) had strong hesitation to work. Demographic characters and stress-related questions were categorised into four types according to the odds ratios (OR) of motivation and hesitation to work: some factors increased motivation and lowered hesitation; others increased motivation only; others increased hesitation only and others increased both motivation and hesitation. The strong feeling of being supported by the national and local governments (Multivariate OR: motivation; 3.5; CI 2.2-5.4, hesitation; 0.2; CI 0.1-0.6) and being protected by hospital (Multivariate OR: motivation; 2.8; CI 2.2-3.7, hesitation; 0.5; CI 0.3-0.7) were related to higher motivation and lower hesitation. Here, protection included taking precautions to prevent illness among workers and their families, providing for the care of those who do become ill, reducing malpractice threats, and financial support for families of workers who die on duty. But 94.1% of the respondents answered protection by the national and local government was weak and 79.7% answered protection by the hospital was weak. Conclusions: Some factors have conflicting effects because they increase both motivation and hesitation. Giving workers the feeling that they are being protected by the national and local government and hospital is especially valuable because it increases their motivation and lowers their hesitation to work.

  BIOMED CENTRAL LTD, Nov. 2010, BMC PUBLIC HEALTH, 10, 672, English

  [Refereed]

  Scientific journal


• A putative cis-acting polymorphism in the NOS1 gene is associated with schizophrenia and NOS1 immunoreactivity in the postmortem brain

  Huxing Cui, Naoki Nishiguchi, Masaya Yanagi, Masaaki Fukutake, Kentaro Mouri, Noboru Kitamura, Takeshi Hashimoto, Osamu Shirakawa, Akitoyo Hishimoto

  Schizophrenia is a devastating neurodevelopmental disorder whose genetic influences remain elusive. Recent genome-wide scans revealed that rare structural variants disrupted multiple genes in neurodevelopmental pathways, which strongly implicate nitric oxide (NO) signaling in schizophrenia. NO acts as a second messenger of N-methyl-D aspartate receptor activation, which further interacts with both dopaminergic and serotonergic pathways. NO is mainly synthesized by neuronal nitric oxide synthase (NOS1) in the brain, and its gene locus, 12q24.2, has attracted much attention as a major linkage region for schizophrenia. Genetic variations of NOS1 have also been associated with schizophrenia, and differential expression of NOS1 was observed in the postmortem brain of schizophrenic patients. Here, we explored the hypothesis that a putative cis-acting G-84A single nucleotide polymorphism (SNP; rs41279104) in the exon 1c promoter region of the NOS1 gene is associated with the levels of NOS1 immunoreactivity in postmortem prefrontal cortex specimens regardless of disease phenotype. Individuals with the A-allele of this SNP showed significantly lower levels of NOS1 immunoreactivity than did GG homozygotes (p=0.002). Furthermore, a case-control study using 720 individuals in a Japanese population revealed a significant association between the SNP and schizophrenia (genotypic p=0.0013 and allelic p=0.0011). Additionally, the average of onset age in schizophrenic patients with the A-allele was significantly earlier than GG homozygotes (p=0.018). When the analyses took gender into account, this significance was more significant for female. These findings provide further evidences that NOS1 is associated with a biological susceptibility gene to schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.

  ELSEVIER SCIENCE BV, Aug. 2010, SCHIZOPHRENIA RESEARCH, 121(1-3) (1-3), 172 - 178, English

  [Refereed]

  Scientific journal


• Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population

  A. Hishimoto, M. Fukutake, K. Mouri, Y. Nagasaki, M. Asano, Y. Ueno, N. Nishiguchi, O. Shirakawa

  Epidemiological studies have shown that excessive alcohol consumption is a potent risk factor to develop suicidal behavior. Genetic factors for suicidal behavior have been observed in family, twin, and adoption studies. Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population. We found that the inactive ALDH2 allele (487Lys) was significantly less frequent in the completed suicides (19.3%) than in the controls (29.3%), especially in males, whereas this was not the case in females. The males bearing alcoholism-susceptible homozygotes at both loci (inactive ADH1B Arg/Arg and active ALDH2 Glu/Glu genotypes) have a 10 times greater risk for suicide compared with the males bearing alcoholism-protective homozygotes at both loci. Our data show the genetic impact of the two polymorphisms on suicidal behavior in the Japanese population, especially in males. Because we did not verify the daily alcohol consumption, the association of these SNPs with suicide might be due to alcoholism itself. Further studies using case-control subjects, which verifies the details of current and past alcohol consumption and diagnosis for alcoholism, are required to confirm these findings.

  WILEY, Jul. 2010, GENES BRAIN AND BEHAVIOR, 9(5) (5), 498 - 502, English

  [Refereed]

  Scientific journal


• Association study of RGS2 gene polymorphisms with panic disorder in Japanese

  Mouri K, Hishimoto Akitoyo, Fukutake M, Nishiguchi N, Shirakawa O, Maeda K

  Genetic factors for panic disorder have been consistently observed in family andtwin studies. Regulators of G-protein signaling (RGS) is a family of proteins thatnegatively regulate the intracellular signaling of G protein-coupled receptors such asdopamine and serotonin receptors. RGS2, one of the RGS families, has been suggestedto plays a role in anxiety and/or aggressive behavior. Polymorphisms in the RGS2 genewere recently associated with panic disorder, trait anxiety, suicidal behavior, andgeneralized anxiety disorder. From these findings, we tried to replicate an associationbetween panic disorder and genetic variations of the RGS2 using a case-control study of186 patients with panic disorder and 380 controls in Japanese. We genotyped fivecommon single nucleotide polymorphisms (SNPs) by the PCR-RFLP method and theTaqMan Assays. Neither genotype distribution nor allele frequency for five SNPs wassignificant different between the panic disorder and control groups. We found arelative tight LD block in the 5'- flanking region of RGS2 gene. One of the commonhaplotypes, AC of rs2746071 and rs2746072, has shown a nominally significantassociation with panic disorder (p=0.027). This significance, however, did not remainafter correction for multiple testing. These findings suggest that RGS2 may not begenetically involved in the biological susceptibility to panic disorder in Japanese.

  Kobe University, Apr. 2010, Kobe J Med Sci, 55(5) (5), E116 - 21, English

  [Refereed]

  Scientific journal

  Link to Kobe Univ. Repository (Kernel)


• Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population.

  Shiroiwa K, Hishimoto A, Mouri K, Fukutake M, Supriyanto I, Nishiguchi N, Shirakawa O

  Mar. 2010, Neuroscience letters, 472(3) (3), 194 - 198

  [Refereed]


• TPH2 is not a susceptibility gene for suicide in Japanese population.

  Mouri K, Hishimoto A, Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K

  BACKGROUND: Serotonergic systems mediate a control of aggression and/or impulsivity in human and are suggested to be involved in suicidal behavior. The newly identified neuronal tryptophan hydroxylase isoform 2 (TPH2), the rate-limiting enzyme in serotonin synthesis, represents a prime candidate in numerous genetic association analyses of suicidal behavior; however, the results are still inconclusive. The discrepancy may result from the heterogeneity of pathogenesis of suicidal behavior and/or methodological mismatches. We, therefore, attempted to replicate the association of TPH2 gene with suicide using a case-control study of 234 completed suicides and 260 control subjects in Japanese population. METHODS: We genotyped 15 tagging-single nucleotide polymorphisms (SNPs) including 4 SNPs, which were previously reported to be associated with suicidal behavior, using the TaqMan probe assays and the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: We found no significant differences in genotypic distributions (uncorrected p=0.06-0.98) or allelic frequencies (uncorrected p=0.09-0.95) of the fifteen SNPs between the completed suicides and control groups. Haplotypes constructed with these SNPs were also not associated with suicide (uncorrected p=0.03-0.96 and corrected p=0.20-1.00). Even when we took sex and suicidal methods (violent or non-violent) into account for the analyses, no significant differences in genotypic distributions, allelic/haplotypic frequencies were found in the two groups. CONCLUSION: Our results suggest that the common SNPs and haplotypes of the TPH2 gene are unlikely to contribute to the genetic susceptibility to suicidal behavior in Japanese population.

  Nov. 2009, Progress in neuro-psychopharmacology & biological psychiatry, 33(8) (8), 1546 - 1550, English, International magazine

  [Refereed]

  Scientific journal


• A functional polymorphism of the mu-opioid receptor gene is associated with completed suicides

  A. Hishimoto, H. Cui, K. Mouri, H. Nushida, Y. Ueno, K. Maeda, O. Shirakawa

  A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the mu-opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a common A118G SNP. The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively). A dominant model analysis of the A118G SNP showed an enhanced association with suicide (P = 0.0041, Odds ratio 0.575) and this significant association was observed with a logistic regression analysis that takes sex and age factors into account (P = 0.021). Our results raise the possibility that the A118G SNP of the OPRM1 gene is associated with suicide.

  SPRINGER WIEN, Mar. 2008, JOURNAL OF NEURAL TRANSMISSION, 115(3) (3), 531 - 536, English

  [Refereed]

  Scientific journal


• 統合失調症死後脳前頭前野におけるProliferation cell nuclear antigen(PCNA)の検討

  福武 将映, 柳 雅也, 北村 登, 橋本 健志, 毛利 健太郎, 白川 治, 前田 潔

  日本神経化学会, Aug. 2006, 神経化学, 45(2-3) (2-3), 361 - 361, Japanese

• 生まれ月(時期)と青年後期における精神的健康及び心理的特性との関連

  足立 祥, 毛利 健太朗, 飛松 崇子, 高橋 健太郎, 藤平 和弘, 井口 元三, 山本 泰司

  背景)同じ学年内において、生まれ月により学力、運動といった能力に差が出ることが知られている。この差は特に低学年で顕著となり、除々に差が縮まると報告されている。しかし、青年後期での差や、精神的健康状態との関連は未知の部分が多い。今回、大学入学時の学生精神的健康調査(UPI)の結果を用い、生まれ月による青年後期での精神的健康度への影響について検討した。方法)2012年～2021年の10年問における神戸大学新入生のうち、入学時にUPIへの回答を行った18歳～19歳の学部新入生20,423人を解析対象とした。4月2日生まれを先頭とし、3ヵ月毎に4期に分け、生まれた時期とUPIの得点及び副次項目の点数(心気的症状、自律神経症状、抑うつ傾向、対人不安、強迫傾向、被害関係念慮、陽性項目(良好な精神状態))との関連を調べた。また、ポアソン分布を仮定した一般化線形モデルを使用し、共変量を調整した関連についても調べた。結果)生まれた時期と陽性項目4項目の平均点との間に有意な関連がみられた(陽性項目平均点(±SD):第一期0.550(±0.923)、第2期0.520(±0.891、第3期0.527(±0.908)、第4期0.497(±0.889),p<0.01)。他の副次項目及び総得点との間には有意な関連はみられなかった。多変量解析の結果、第4期生まれは第1期生まれに比べ、陽性項目が有意に低くなっていた。(点数比:0.90(95%信頼区間:0.85-0.95,p<0.001))。考察)いわゆる「早生まれ」と呼ばれる、第4四半期生まれの子供は、青年後期において、良好な精神的健康状態が見られにくいことが明らかとなった。一方で、不良な精神的健康度の項目に差はなかった。これらの結果から、早生まれの子供は、自身の精神的健康に対する肯定的認知が低い可能性が考えられ、生育過程での心理的支援の必要性が考えられた。(著者抄録)

  (NPO)全国大学メンタルヘルス学会, Jun. 2024, 大学のメンタルヘルス, 6, 66 - 67, Japanese


• 精神疾患のエピジェネティクス研究 自殺のエピジェネティクス

  岡崎 賢志, 大塚 郁夫, 谷藤 貴紀, 白井 寿行, 毛利 健太朗, 菱本 明豊

  日本臨床精神神経薬理学会・日本神経精神薬理学会, May 2024, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 34回・54回, JSY1 - 3, Japanese


• インターネットゲーム障害における認知機能障害について-MCCB日本語版による検討-

  南陽香, 谷藤貴紀, 白井寿行, 大塚郁夫, 毛利健太朗, 岩本直子, 倉永雅子, 菱本明豊

  2024, 精神神経学雑誌, 126(2) (2)


• 生まれ月(時期)と青年後期における精神的健康及び心理的特性との関連

  足立祥, 毛利健太朗, 毛利健太朗, 飛松崇子, 高橋健太郎, 藤平和弘, 井口元三, 井口元三, 山本泰司, 山本泰司

  2024, 大学のメンタルヘルス(Web), 6


• アルコール依存症でのエピゲノム年齢加速

  白井寿行, 岡崎賢志, 大塚郁夫, 南陽香, 岡田将平, 宮地真生, 蓬莱政, 毛利健太朗, 菱本明豊

  2024, 日本精神科診断学会プログラム・抄録集, 43rd


• 未治療のうつ病患者におけるエピジェネティック年齢の加速とDNAメチル化に基づくナチュラルキラー細胞の減少

  岡崎賢志, 新藤良太, 谷藤貴紀, 大塚郁夫, 白井寿行, 毛利健太朗, 蓬莱政, 菱本明豊

  2024, 日本精神科診断学会プログラム・抄録集, 43rd


• 日本人の自殺既遂者における,マクロファージ遊走阻害因子(MIF)の低酸素応答因子における遺伝子研究

  宮地真生, 白井寿行, 岡崎賢志, 谷藤貴紀, 大塚郁夫, 岡田将平, 新藤良太, 蓬莱政, 毛利健太郎, 高橋玄倫, 近藤武史, 上野易弘, 菱本明豊

  2024, 日本生物学的精神医学会(Web), 46th


• メタンフェタミン依存症におけるエピゲノムワイド関連研究

  白井寿行, 岡崎賢志, 谷藤貴紀, 大塚郁夫, 蓬莱政, 毛利健太朗, 麻生克郎, 山本訓也, 菱本明豊

  2024, 日本生物学的精神医学会(Web), 46th


• DNAメチル化に代表される後天的遺伝子修飾と精神疾患の解明

  白井寿行, 岡崎賢志, 大塚郁夫, 谷藤貴紀, 宮地真生, 岡田将平, 蓬莱政, 毛利健太朗, 菱本明豊

  2024, 統合失調症研究(CD-ROM), 13(1) (1)


• SNS感情分析を用いた、大学を取り巻く環境でのストレス要因抽出の試み

  足立 祥, 毛利 健太朗, 山本 泰司

  既報により、学業状況や人間関係等が大学生のストレス要因となりうることが示されているが、大学生のストレス要因の全容は不明なままである。機械学習によるTwitter等のソーシャルメディアネットワーク(SNS)における感情の抽出方法は発展を遂げている。今回、我々はSNSにおける自然言語処理モデルを用いた感情分析を通して、大学を取り巻く環境でのストレス要因抽出とその評価を試みた。Twitterにおいて、「神戸大学」等のキーワードにより、大学環境に係るツイートを定期的に抽出した。抽出されたツイートの内容を自然言語処理モデルにより解析し、感情極性を評価するとともに、ネガティブと判定されたツイートに関連するキーワードを抽出の上カテゴリー分けを行い、ストレス要因としての評価を行った。2022年4月1日～9月30日において、71191件のツイートが収集され、その内、自動送信と考えられるツイートを除いた52584件を解析の対象とした。感情分析により、ネガティブと判定されたツイートは、2615件(5.0%)であった。含まれる要素の分析を行ったところ、入試、勉学、地域、Twitter、健康、社会情勢、人間関係、サークル活動、アルバイトといったカテゴリーに分類されるキーワードが抽出された。今回の結果では、既報と同様のストレス因に加え、時事的なストレス因についても抽出されていた。今回の方法は、大規模かつ簡便に行うことができ、大学生のストレス因を抽出するツールとなる可能性が示唆された。(著者抄録)

  (NPO)全国大学メンタルヘルス学会, Dec. 2023, 大学のメンタルヘルス, 7, 76 - 78, Japanese


• Association of two variable number of tandem repeats in the monoamine oxidase A gene promoter with suicide completion: the present study and meta-analysis.

  谷藤貴紀, 長谷川雅史, 岡崎賢志, 大塚郁夫, 白井寿行, 新藤良太, 蓬莱政, 毛利健太郎, 高橋玄倫, 近藤武史, 上野易弘, 菱本明豊

  2023, 日本生物学的精神医学会(Web), 45th


• COVID-19パンデミックの前後における大学職員の精神的ストレスの変化に関する検討

  谷藤貴紀, 毛利健太朗, 山本泰司, 青山慎介

  2023, 日本精神神経学会総会プログラム・抄録集, 119th


• Epigenetic clock analysis in methamphetamine dependence

  白井寿行, 竹村幸洋, 竹村幸洋, 谷藤貴紀, 岡崎賢志, 大塚郁夫, 新光穣, 岡田将平, 宮地真生, 蓬莱政, 毛利健太朗, 麻生克郎, 山本訓也, 菱本明豊

  2023, 日本生物学的精神医学会(Web), 45th


• SNS感情分析を用いた,大学を取り巻く環境でのストレス要因抽出の試み

  足立祥, 毛利健太朗, 毛利健太朗, 山本泰司, 山本泰司

  2023, 大学のメンタルヘルス(Web), 7


• 再雇用就労制度における産業医の役割について~10年間の集計結果より~

  藤平和弘, 飛松崇子, 高橋健太郎, 足立祥, 毛利健太朗, 毛利健太朗, 楠田康子, 林原礼子, 近藤泰子, 長尾伸子, 大崎絵里子, 寺内千春, 菅尾有紀子, 岡本眞智子, 三村祐子, 和田矩子, 別祖香代, 篠原正和, 篠原正和, 井口元三, 井口元三, 山本泰司, 山本泰司

  2023, Campus Health (CD-ROM), 60(1) (1)


• コロナ禍前後の大学生における体重変化の実態~神戸大学での検討~

  飛松崇子, 井口元三, 井口元三, 楠田康子, 林原礼子, 近藤泰子, 長尾伸子, 大崎絵里子, 寺内千春, 菅尾有紀子, 別祖香代, 和田矩子, 足立祥, 毛利健太朗, 毛利健太朗, 高橋健太郎, 山本泰司, 山本泰司

  2023, Campus Health (CD-ROM), 60(1) (1)


• 働き方改革関連法(改正労働基準法)施行による長時間労働状況の変化~本学における長時間労働者への面接指導について法令改正前後の比較~

  藤平和弘, 毛利健太朗, 毛利健太朗, 飛松崇子, 高橋健太郎, 楠田康子, 林原礼子, 近藤泰子, 鹿野伸子, 有村和代, 寺内千春, 谷口真理子, 菅尾有紀子, 木田綾子, 池上峰子, 岡本眞智子, 家倉宏子, 別祖香代, 篠原正和, 篠原正和, 井口元三, 井口元三, 山本泰司, 山本泰司

  2021, Campus Health (CD-ROM), 58(1) (1)


• UPIにおける大学生の回答への回避についての検討

  足立祥, 毛利健太朗, 毛利健太朗, 飛松崇子, 高橋健太郎, 藤平和弘, 井口元三, 井口元三, 楠田康子, 林原礼子, 近藤泰子, 鹿野伸子, 大崎絵里子, 山本泰司, 山本泰司

  2021, 全国大学保健管理研究集会プログラム・抄録集, 59th (CD-ROM)


• 健康診断におけるWEB問診システムの利用~コロナ禍における遠隔での健康管理~

  藤平和弘, 飛松崇子, 高橋健太郎, 足立祥, 毛利健太朗, 毛利健太朗, 菅尾有紀子, 寺内千春, 有村和代, 大崎絵里子, 鹿野伸子, 近藤泰子, 林原礼子, 楠田康子, 和田矩子, 別祖香代, 井口元三, 井口元三, 山本泰司, 山本泰司

  2021, 全国大学保健管理研究集会プログラム・抄録集, 59th (CD-ROM)


• 機械学習を活用したストレスチェックに基づくメンタルヘルス不調の予測モデル構築

  井口元三, 井口元三, 飛松崇子, 高橋健太郎, 藤平和弘, 足立祥, 毛利健太朗, 毛利健太朗, 楠田康子, 林原礼子, 近藤泰子, 山本泰司, 山本泰司

  2021, 全国大学保健管理研究集会プログラム・抄録集, 59th (CD-ROM)


• 神戸大学における新型コロナワクチン職域接種~全学一丸となって取り組んだ活動報告~

  鹿野伸子, 井口元三, 井口元三, 藤平和弘, 高橋健太郎, 飛松崇子, 毛利健太朗, 毛利健太朗, 足立祥, 楠田康子, 林原礼子, 近藤泰子, 大崎絵里子, 寺内千春, 有村和代, 菅尾有紀子, 山本泰司, 山本泰司

  2021, 全国大学保健管理研究集会プログラム・抄録集, 59th (CD-ROM)


• 高齢労働者の再雇用就労における就業上の配慮・措置について 産業医の役割

  藤平 和弘, 飛松 崇子, 高橋 健太郎, 井口 元三, 毛利 健太朗, 篠原 正和, 山本 泰司

  (一社)日本老年医学会, Jul. 2020, 日本老年医学会雑誌, 57(Suppl.) (Suppl.), 137 - 137, Japanese


• オフライン健診での専用リライトカードから汎用タブレットPCとICカードへの移行

  林原 礼子, 近藤 泰子, 高橋 健太郎, 井口 元三, 楠田 康子, 鹿野 伸子, 大崎 絵里子, 谷口 真理子, 寺内 千春, 菅尾 由起子, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2020, CAMPUS HEALTH, 57(1) (1), 84 - 85, Japanese


• 神戸大学「麻疹風疹登録制度」 全学休校から始まった10年の軌跡

  高橋 健太郎, 井口 元三, 楠田 康子, 林原 礼子, 近藤 泰子, 鹿野 伸子, 大崎 絵里子, 谷口 真理子, 寺内 千春, 菅尾 有紀子, 池上 峰子, 岡本 眞智子, 谷川 直子, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Mar. 2020, CAMPUS HEALTH, 57(1) (1), 194 - 194, Japanese


• オフライン健診での専用リライトカードから汎用タブレットPCとICカードへの移行

  林原 礼子, 近藤 泰子, 高橋 健太郎, 井口 元三, 楠田 康子, 鹿野 伸子, 大崎 絵里子, 谷口 真理子, 寺内 千春, 菅尾 有紀子, 家倉 宏子, 別祖 香代, 毛利 健太朗, 飛松 崇子, 藤平 和弘, 馬場 久光, 山本 泰司

  (公社)全国大学保健管理協会, Sep. 2019, 全国大学保健管理研究集会プログラム・抄録集, 57回, 41 - 41, Japanese


• 神戸大学におけるストレスチェックの実施および初年度の結果報告

  Yasuji Yamamoto, Mouri Kentaro, Baba Hisamitsu

  2018, CAMPUS HEALTH, 54, 136 - 138, Japanese

  Meeting report


• 日本人自殺既遂者におけるMIF遺伝子プロモーター領域機能的多型の関連解析(Association study of MIF promoter polymorphosms with suicide completers in the Japanese population)

  新名 尚史, 菱本 明豊, 大塚 郁夫, 岡崎 賢志, 朴 秀賢, 毛利 健太朗, 蓬莱 政, 江口 典臣, 木村 敦, 山木 愛久, 平田 尚士, 高橋 玄倫, 上野 易弘, 白川 治, 曽良 一郎

  日本生物学的精神医学会・日本神経精神薬理学会, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, 39回・47回, 190 - 190, English


• Possible role of CDH13 in nicotine dependence: Investigations on mouse neural progenitors and schizophrenia patients

  Ikuo Otsuka, Akitoyo Hishimoto, Shuken Boku, Satoshi Okazaki, Kentaro Mouri, Ichiro Sora

  OXFORD UNIV PRESS, Jun. 2016, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19, 160 - 160, English

  Summary international conference


• 統合失調症におけるIL-19遺伝子の発現量的形質遺伝子座(eQTL)におけるハプロタイプ解析

  岡崎 賢志, 渡部 雄一郎, 大塚 郁夫, 吉田 正邦, 白岩 恭一, 毛利 健太朗, ウォラパット・ラッタアーパー, イルワン・スプリヤント, 江口 典臣, 笹田 徹, 福武 将映, 布川 綾子, 染矢 俊幸, 白川 治, 菱本 明豊, 曽良 一郎

  日本臨床精神神経薬理学会・日本神経精神薬理学会, Oct. 2013, 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, 23回・43回, 230 - 230, Japanese


• 気分障害における自殺傾性と関連する心理学的特性

  福武 将映, 毛利 健太朗, 西口 直希, 北村 登, 白川 治

  (公社)日本精神神経学会, May 2013, 精神神経学雑誌, (2013特別) (2013特別), S - 660, Japanese


• ALCOHOL AND ALDEHYDE DEHYDROGENASE POLYMORPHISMS AND RISK FOR SUICIDE

  A. Hishimoto, M. Fukutake, K. Mouri, K. Shiroiwa, T. Sasada, Y. Nagasaki, M. Asano, Y. Ueno, O. Shirakawa

  WILEY-BLACKWELL, Sep. 2012, ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 36, 50A - 50A, English

  Summary international conference


• 入院患者の転倒におけるリスク要因

  毛利 健太朗, 新光 穣, 伊藤 篤, 今井 必生, 伊藤 聡子, 松石 邦隆, 北村 登

  (公社)日本精神神経学会, May 2012, 精神神経学雑誌, (2012特別) (2012特別), S - 448, Japanese


• 神戸市立医療センター中央市民病院でのせん妄ケアチームの試み

  Mouri Kentaro

  Functioning as a regional acute care hospital, our emergency medical center widely accepts patients in primary ~ tertiary emergencies. A preliminary study revealed that 18.5% of all inpatients experience delirium which is similar to the percent reported by other institutes. The study also states that half of falling accidents among the incident cases occurs during periods of delirium. Because delirium greatly complicates medical management, detection and intervention to prevent delirium in its early stage is important. In 2009, we and other medical professionals formed a delirium care team (DCT), whose main goal is the prevention of occurrence and worsening of delirium by early intervention. Our DCT consists of psychiatrists, nurses, pharmacists and physical therapists. DCT members make the rounds of all wards every day, consulting with inpatients with delirium or a high risk of delirium. The DCT arranges medication, reinforces cognitive orientation, estimates pain and educates inpatients and their relatives about delirium. DCT members hold a conference about inpatients with delirium every month. Once a year, an educational conference about delirium is held for the hospital staff. Because many wards rely on DCT activities for a rapid response to delirium, team intervention to prevent delirium can decrease psychological distress of the hospital staff caring for inpatients with delirium. The number of interventions by the DCT has been increasing reaching 413 inpatients in 2011. Based on our recent experience, the DCT has been most successful in preventing the worsening of delirium rather than preventing delirium itself. Because our hospital is obligated to treat emergencies, making the rounds of the wards by the DCT consisting of various medical professions has made a significant contribution to the treatment of delirium.

  Japanese Society of General Hospital Psychiatry, Apr. 2012, 総合病院精神医学, 24(2号) (2号), 146 - 154, Japanese

  Introduction scientific journal


• Two Cases of Isolated ACTH Deficiency who Suspected out of Depression with Severe Appetite Loss

  MATSUISHI Kunitaka, IMAI Hissei, ITO Atsushi, MOURI Kentaro, KITAMURA Noboru, TAMIYA Satoshi, MITA Tatsuo, FUJIMOTO Kanta, ISHIHARA Takashi

  日本精神神経学会, 25 Nov. 2010, 精神神經學雜誌 = Psychiatria et neurologia Japonica, 112(11) (11), 1073 - 1081, Japanese


• ALCOHOL AND ALDEHYDE DEHYDROGENASE POLYMORPHISMS AND RISK FOR SUICIDE

  A. Hishimoto, K. Mouri, M. Fukutake, K. Shiroiwa

  ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2010, EUROPEAN PSYCHIATRY, 25, English

  Summary international conference


• 自殺とPBR遺伝子多型との相関研究

  毛利健太朗, 白川治, 崔虎星, 福武将映, 柳雅也, 西口直希, 主田英之, 上野易弘, 長崎靖, 前田潔

  2007, 日本生物学的精神医学会プログラム・講演抄録, 29th


• 自殺者におけるP11遺伝子多型

  崔虎星, 西口直希, 柳雅也, 福武将映, 毛利健太朗, 主田英之, 上野易弘, 白川治, 前田潔

  2007, 日本生物学的精神医学会プログラム・講演抄録, 29th


• 精神科的治療を行った飛び降り自殺企図症例の検討

  毛利 健太朗, 吉住 寿美香, 田淵 実治郎, 田中 究, 白川 治, 前田 潔

  (公社)日本精神神経学会, Jun. 2006, 精神神経学雑誌, 108(6) (6), 677 - 677, Japanese


• 飛び降り自殺企図症例の精神医学的検討

  毛利 健太朗, 吉住 寿美香, 田淵 実治郎, 田中 究, 白川 治, 前田 潔

  (公社)日本精神神経学会, May 2006, 精神神経学雑誌, (2006特別) (2006特別), S367 - S367, Japanese

• Epigenetic clock analysis of blood samples from Japanese schizophrenia patients

  Satoshi Okazaki, Ikuo Otsuka, Shusuke Numata, Tadasu Horai, Kentaro Mouri, Shuken Boku, Tetsuro Ohmori, Ichiro Sora, Akitoyo Hishimoto

  7th Congress of Asian College of Neuropsychopharmacology (AsCNP) 2021, Oct. 2021


• UPIを用い呼び出し面接を行った学生の経過とその検討

  Mouri Kentaro, Yamamoto Yasuji, Baba Hisamitsu

  第56回全国大学保健管理研究集会, Oct. 2018, Japanese, 公益社団法人 全国大学保健管理協会・国立大学法人 東京大学, きゅりあん（品川区立総合区民会館）, Domestic conference

  Poster presentation


• メンタルヘルス(2)

  MOURI KENTARO

  平成30年度海事科学部共通専門科目「船舶衛生」, Jul. 2018, Japanese, 神戸大学海事科学部, 神戸, Domestic conference

  Public discourse


• 神戸大学におけるストレスチェックの実施および初年度の結果報告

  Yamamoto Yasuji, 毛利 健太朗, Baba Hisamitsu

  第55回全国大学保健管理研究集会, Nov. 2017, Japanese, 全国大学保健管理協会, 京都, Domestic conference

  Poster presentation


• 日本人自殺既遂者におけるMIF遺伝子プロモーター領域機能的多型の関連解析

  新名 尚史, Hishimoto Akitoyo, Otsuka Ikuo, 岡崎 賢志, Boku Shuken, 毛利 健太朗, 蓬莱 政, 江口 典臣, 木村 敦, 山木 愛久, 平田 尚士, Takahashi Motonori, Ueno Yasuhiro, 白川 治, Ichiro Sora

  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会, Sep. 2017, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 札幌, Domestic conference

  Poster presentation


• 自殺既遂者におけるテロメア異常短縮

  Otsuka Ikuo, Hishimoto Akitoyo, 泉 剛, Boku Shuken, 木村 敦, 張 園, 毛利 健太朗, 岡崎 賢志, Takahashi Motonori, Ueno Yasuhiro, 白川 治, Ichiro Sora

  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会, Sep. 2017, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 札幌, Domestic conference

  Oral presentation


• メンタルヘルス(1)

  毛利 健太朗

  平成28年度海事科学部共通専門科目「船舶衛生」, Jul. 2017, Japanese, 神戸大学海事科学部, 神戸, Domestic conference

  Public discourse


• 自閉症スペクトラム障害を合併した摂食障害の1例

  奥小路 明子, Tamiya Hiroko, Mouri Kentaro, Sasada Toru, Hishimoto Akitoyo, Ichiro Sora

  第118回近畿精神神経学会, Feb. 2016, Japanese, 近畿精神神経学会, 奈良, Domestic conference

  Oral presentation


• 危険ドラッグの臨床症状にへの影響および遺伝子多形との関連の検討

  岡﨑 賢志, Hishimoto Akitoyo, Boku Shuken, Mouri Kentaro, 竹村 幸洋, 麻生 克郎, 山本 訓也, Ichiro Sora

  平成27年度アルコール・薬物依存関連問題学会合同学術総会, Oct. 2015, Japanese, アルコール・薬物依存関連問題学会、日本依存性神経精神科学会, 神戸, Domestic conference

  Oral presentation


• 統合失調症における細胞周期関連遺伝子に着目した3段階mRNA発現解析

  岡﨑 賢志, Hishimoto Akitoyo, Boku Shuken, Mouri Kentaro, Shiroiwa Kyoichi, 大塚 郁夫, 白井 豊, 藤田 愛子, 白川 治, 湖海 正尋, Ichiro Sora

  第37回日本生物学的精神医学会・第45回日本神経精神薬理学会, Sep. 2015, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 東京, Domestic conference

  Oral presentation


• 統合失調症におけるCadherin13遺伝子多形解析

  大塚 郁夫, 渡部 雄一郎, Hishimoto Akitoyo, Boku Shuken, Mouri Kentaro, Shiroiwa Kyoichi, 岡﨑 賢志, 布川 綾子, 白川 治, 染矢 俊幸, Ichiro Sora

  第37回日本生物学的精神医学会・第45回日本神経精神薬理学会, Sep. 2015, Japanese, 日本生物学的精神医学会・日本神経精神薬理学会, 東京, Domestic conference

  Oral presentation


• 災害派遣精神医療チームDPAT（Disaster Psychiatric Assistance Team）の災害支援のあり方

  井上 貴裕, Aoyama Shinsuke, Mouri Kentaro, Boku Shuken, Hishimoto Akitoyo, Ichiro Sora

  第117回近畿精神神経学会, Jul. 2015, Japanese, 近畿精神神経学会, 大阪, Domestic conference

  Oral presentation


• Early life stress attenuates the capacity of adult neural precursor cells to differentiate into neurons via methylation of retinoic acid receptor gene promoter

  Boku Shuken, 戸田 裕之, Hishimoto Akitoyo, Mouri Kentaro, 岡崎 賢志, 廣井 昇, 中川 伸, 久住 一郎

  The International College of Neuropsychopharmacology 2015, Jun. 2015, English, The International College of Neuropsychopharmacology, DUBRIN, Irish, International conference

  Poster presentation


• 神戸大学医学部附属病院におけるblonanserinの投与状況について

  Shiroiwa Kyoichi, Mouri Kentaro, Sasada Toru, 大塚 郁夫, 大本 暢子, Hishimoto Akitoyo, Ichiro Sora

  第24回日本臨床精神神経薬理学会/第44回日本神経精神薬理学会, Nov. 2014, Japanese, 名古屋, Domestic conference

  Poster presentation


• 統合失調症とＨＬＡ-ＤＲＢ1*04の遺伝子関連解析

  岡﨑 賢志, Hishimoto Akitoyo, 渡部 雄一郎, ラッタアーパーウォラパット, Mouri Kentaro, Shiroiwa Kyoichi, Sasada Toru, 江口 典臣, 大塚郁夫, 布川 綾子, 澁谷 雅子, 染矢 俊幸, Ichiro Sora

  第36回日本生物学的精神医学会・第57回日本神経化学大会 合同年会, Sep. 2014, Japanese, 日本生物学的精神医学会・日本神経化学大会, 奈良, Domestic conference

  Poster presentation


• マイクロＲＮＡ138-2遺伝子の稀な変異と統合失調症の関連

  渡部 雄一郎, Hishimoto Akitoyo, 澁谷 雅子, 布川 綾子, 金子 尚史, 井桁 裕文, 江川 純, Mouri Kentaro, Ichiro Sora, 染矢 俊幸

  第36回日本生物学的精神医学会・第57回日本神経化学大会 合同年会, Sep. 2014, Japanese, 日本生物学的精神医学会・日本神経化学大会, 奈良, Domestic conference

  Poster presentation


• Specific circulating micro-RNA in acute and chronic schizophorenia.

  Hishimoto Akitoyo, W.Ratta-apha, Satoshi Okazaki, Mouri Kentaro, Shiroiwa Kyoichi, Sasada Toru, Ikuo Otsuka, Noriomi Eguchi, Ichiro Sora

  The 16th World Cogress of Psychiatry, Sep. 2014, English, Madrid, Spain, International conference

  Poster presentation


• 反復性うつ病の入院治療中に多飲水行動を呈した1例

  小林 明美, 石丸 綾子, Sasada Toru, Shiroiwa Kyoichi, Mouri Kentaro, Yamamoto Yasuji, Hishimoto Akitoyo, Tanaka Kiwamu, Ichiro Sora

  第115回近畿精神神経学会, Jul. 2014, Japanese, 近畿精神神経学会, 大阪, Domestic conference

  Oral presentation


• 当院における精神科リエゾンチーム活動報告：精神科リエゾンチーム加算の算定を開始して

  松本 いずみ, 曽根原 純子, Tamiya Hiroko, Sasada Toru, Matsui Yusuke, Mouri Kentaro, Shiroiwa Kyoichi, 田中 知子, 長谷川 雅史, 大塚 郁夫, 古野 和歌子, 山木 愛久, 牧野 祥久, Ichiro Sora

  第26回日本総合病院精神医学会総会, Nov. 2013, Japanese, 京都, Domestic conference

  Oral presentation


• 慢性疼痛へのセロトニン・ノルアドレナリン再取り込み阻害薬デュロキセチンの有効性

  大塚 郁夫, Shiroiwa Kyoichi, Hishimoto Akitoyo, Mouri Kentaro, Sasada Toru, Ichiro Sora

  第23回日本臨床精神神経薬理学会、第43回日本神経精神薬理学会, Oct. 2013, Japanese, 沖縄, Domestic conference

  Oral presentation


• 統合失調症におけるIL-19遺伝子の発現量的形質遺伝子座(eQTL）におけるハプロタイプ解析

  岡﨑 賢志, 渡部 雄一郎, 大塚 郁夫, 吉田 正邦, Shiroiwa Kyoichi, Mouri Kentaro, ウォラパット ラッタアーパー, イルワン スプリヤント, 江口 典臣, Sasada Toru, 福武 将映, 布川 綾子, 染矢 俊幸, 白川 治, Hishimoto Akitoyo, Ichiro Sora

  第23回日本臨床精神神経薬理学会、第43回日本神経精神薬理学会, Oct. 2013, Japanese, 沖縄, Domestic conference

  Oral presentation


• 我々はいかにして彼を同意無能力と判定したか－慢性腎臓病を伴う統合失調症患者の透析導入検討に際して－

  宋 龍平, Mouri Kentaro, Tamiya Hiroko, Tanaka Kiwamu, Ichiro Sora

  第113回近畿精神神経学会, Jul. 2013, Japanese, 近畿精神神経学会, 大阪, Domestic conference

  Oral presentation


• Association study of KIF17 genes with schizophrenia in the Japanese population.

  Mouri Kentaro, Shiroiwa Kyoichi, Masakuni Yoshida, Rattaappa Woraphat, Noriomi Eguchi, Satoshi Okazaki, Masaaki Fukutake, Supriyant Irwan, Sasada Toru, Akitoyo Hishinoto, Ichiro Sora

  11th World Congress of Biological Psychiatry, Jun. 2013, English, Kyoto, International conference

  Poster presentation


• 気分障害における自殺傾性と関連する心理学的特性

  福武 将映, Mouri Kentaro, 西口 直希, 北村 登, 白川 治

  第109回日本精神神経学会学術総会, May 2013, Japanese, 福岡, Domestic conference

  Oral presentation


• Association of HLA-DRB*01 and HLA-DRB*04 with schizophrenia in the Japanese population.

  Woraphat Ratta-Apha, Mouri Kentaro, Shiroiwa Kyoichi, Sasada Toru, Irwan Supriyanto, Noriomi Eguchi, Satoshi Okazaki, Akitoro Hishimoto

  11th World Congress of Biological Psychiatry, Jan. 2013, English, World Federation of Societies of Biological Psychiatry, 京都, International conference

  Oral presentation


• Haplotypes in the expression quantitative trait locus of interleukin-1βgene are associated with schizophrenia

  Yoshida Masaru, Shiroiwa Kyoichi, Mouri Kentaro, Sasada Toru, H. Ishiguro, T.Inada, T.Arinami, O.Shirakawa, Hishimoto Akitoyo

  ASHG(American Society of Human Genetics), Nov. 2012, English, サンフランシスコ, International conference

  Poster presentation


• Association and Expression analysis of DISC1 gene in schizophrenia and completed suicide

  ウォラパット ラッタアッパ, Mouri Kentaro, Irwan Supriyanto, 福武 将映, Sasada Toru, Shiroiwa Kyoichi, 吉田 正邦, 江口 典臣, 岡崎 賢志, 浅野 水辺, 長崎 靖, Ueno Yasuhiro, 白川 治, Hishimoto Akitoyo

  第34回日本生物学的精神医学会, Sep. 2012, English, 日本生物学的精神医学会, 神戸, Domestic conference

  Poster presentation


• Association study between the eQTL of theIL1B gene polymorphism and completed suicide

  岡崎 賢志, 吉田 正邦, Shiroiwa Kyoichi, Mouri Kentaro, Woraphat Ratta-apha, Irwan Supriyanto, 江口 典臣, Sasada Toru, 福武 将映, 浅野 水辺, 長崎 靖, Ueno Yasuhiro, 白川 治, Hishimoto Akitoyo

  第34回日本生物学的精神医学会, Sep. 2012, Japanese, 日本生物学的精神医学会, 神戸, Domestic conference

  Poster presentation


• Haplotaypes in the eQTL of the 1L1B gene are associated wth schizophrenia

  吉田 正邦, Shiroiwa Kyoichi, Mouri Kentaro, Irwan Supriyanto, Woraphat Ratta-apha, 江口 典臣, 岡崎 賢志, Sasada Toru, 福武 将映, 稲田 俊也, 石黒 浩毅, 有波 忠雄, 白川 治, Hishimoto Akitoyo

  第34回日本生物学的精神医学会, Sep. 2012, Japanese, 日本生物学的精神医学会, 神戸, Domestic conference

  Oral presentation


• A genetic variation of NOS1is associated with schizophrenia and NOS1 expression in the brain

  Hishimoto Akitoyo, 崔虎星, 西口 直希, 柳 雅也, 福武 将映, Mouri Kentaro, 北村 登, Hashimoto Takeshi, 白川 治

  第32回日本生物学的精神医学会, Oct. 2010, Japanese, 日本生物学的精神医学会, 福岡, Domestic conference

  Oral presentation

• 大学生の末梢血テロメア長を用いた若年自殺リスクマーカーの確立

  毛利 健太朗, 山本 泰司, 高橋 健太郎, 大塚 郁夫, 足立 祥

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2021 - 31 Mar. 2024

  若年者の高い自殺率に大学生世代の自殺問題が占める割合は非常に大きく、支援体制の充実や自殺予防教育の徹底といった対策がとられているものの、大学生の自殺率は大きく改善していない。むしろ、コロナ禍において若者の自殺は増加に転じている。そのような中、申請者らは世界最大規模の自殺者血液試料を有する強みを生かし、「日本人若年自殺者において末梢血テロメア長が顕著に短縮している」現象を見出した。 申請者は毎年約4000人の大学生に対し自殺リスクのスクリーニングを行う立場であり、自殺ハイリスク学生の末梢血テロメア長を継時的に測定 し、自殺念慮・自殺企図の有無や心理学的検査などの推移との関連や、対照となる健康な学生のテロメア長との比較を行うことで、非侵襲的かつ簡便に採取・定量できる末梢血テロメア長が、若年者の自殺リスクの生物学的指標として有用かどうかを検討していく。自殺の早期発見・予防には、バイオマーカーの確立と生物学的病態機序の解明が不可欠である。特に若年者の高い自殺率に大学生世代の自殺問題が占める割合は非常に大きい。我々は世界最大規模の自殺者血液試料を有する強みを生かして「日本人若年自殺者において末梢血テロメア長が顕著に短縮している」ことを見出した。本研究において自殺ハイリスク学生の末梢血テロメア長を測定し、自殺念慮・抑うつ・ストレス反応の評価スコアの推移や自殺企図の有無との関連、同年代の健康な学生のテロメア長を対照とした比較解析を行うことで、末梢血テロメア長が自殺リスクのバイオマーカーとして有用かどうかを検討し、最終的にはそのデータを元に、若年者の自殺予防に有用な世界初のバイオマーカーを簡便かつ非侵襲的に採取可能な末梢血サンプルでの測定というパッケージにて確立することを目指している。


• テロメア長に着目した若年者の自殺リスクマーカーの開発

  毛利 健太朗

  学術研究助成基金助成金／基盤研究(C), Apr. 2018 - Mar. 2021, Principal investigator

  Competitive research funding


• AD／HDのｉＰＳ細胞を用いた生物モデルの解析

  曽良 一郎

  科学研究費補助金／基盤研究(B), Apr. 2016 - Mar. 2019

  Competitive research funding


• 精神疾患由来幹細胞からの中脳皮質辺縁系ドーパミン神経(A10)の解析

  曽良 一郎

  学術研究助成基金助成金／挑戦的萌芽研究, Apr. 2016 - Mar. 2018

  Competitive research funding


• iPS細胞を用いた統合失調症グルタミン酸仮説の検討

  毛利 健太朗

  学術研究助成基金助成金／若手研究(B), Apr. 2015 - Mar. 2017, Principal investigator

  Competitive research funding


• CRISPR/Cas9 法を用いた自殺感受性遺伝子の機能解析

  毛利健太朗

  GSKジャパン研究助成, 2015, Principal investigator