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UESHIMA EisukeGraduate School of Medicine / Faculty of Medical SciencesAssistant Professor
Research activity information
■ Award- Mar. 2024 JVIR Editor’s Award for Distinguished Laboratory Investigation
- May 2023 日本IVR学会, 優秀論文賞(掲載論文), 【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義
- Apr. 2021 日本医学放射線学会, 栗林研究奨励賞, Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model.
- Jun. 2019 兵庫県健康財団, 兵庫県健康財団 令和元年度がん研究奨励賞, 肝癌局所療法後に生じる免疫抑制性サイトカインの産生メカニズムの解明および阻害法の探索
- Apr. 2019 日本医学放射線学会, 2018年度Bayer研究助成受賞, 肝細胞癌に対するレンバチニブとTACE併用療法:ラット肝癌モデルを用いた検討
- Apr. 2019 Japanese Society of Radiology, 2018 JJR excellent paper, Classification of uterine artery angiographic images: a predictive factor of failure in uterine artery embolization for postpartum hemorrhage
- Mar. 2015 Society of Interventional Radiology(SIR), 2014 JVIR Editor’s Award for Outstanding Laboratory Investigation, Inhibition of Growth in a Rabbit VX2 Thigh Tumor Model with Intraarterial Infusion of Carbon Dioxide (CO2)-saturated SolutionInternational society
- The Japanese Society of Interventional Radiology, Mar. 2025, Interventional Radiology, 10, e2023 - 0048Scientific journal
- The Japanese Society of Interventional Radiology, Mar. 2025, Interventional Radiology, 10, e2024 - 0018Scientific journal
- Background/Objectives: Although immunotherapy is the primary treatment option for intermediate-stage hepatocellular carcinoma (HCC), its efficacy varies. This study aimed to identify non-invasive imaging biomarkers predictive of the immunoscore linked to dynamic contrast-enhanced computed tomography (CECT). Methods: We performed immunohistochemical staining with CD3+ and CD8+ antibodies and counted the positive cells in the invasive margin (IM) and central tumor (CT), converting them to an immunoscore of 0 to 4 points. We assessed the dynamic CECT findings obtained from 96 patients who underwent hepatectomy for HCC and evaluated the relationship between dynamic CECT findings and immunoscores. For validation, we assessed the treatment effects on 81 nodules using the Response Evaluation Criteria in Solid Tumors in another cohort of 41 patients who received combined immunotherapy with atezolizumab and bevacizumab (n = 27) and durvalumab and tremelizumab (n = 14). Results: HCCs with peritumoral enhancement in the arterial phase (p < 0.001) and rim APHE (p = 0.009) were associated with the immunoscore in univariate linear regression analysis and peritumoral enhancement in the arterial phase (p = 0.004) in multivariate linear regression analysis. The time to nodular progression in HCCs with peritumoral enhancement in the arterial phase was significantly longer than that in HCCs without this feature (p < 0.001). Conclusions: We identified HCCs with peritumoral enhancement in the arterial phase as a noninvasive imaging biomarker to predict immune-inflamed HCC with a high immunoscore tendency. These HCCs were most likely to respond to combined immunotherapy.Mar. 2025, Cancers, 17(6) (6), English, International magazineScientific journal
- BACKGROUND/AIM: A standard mouse model of pulmonary fibrosis has been created by intratracheal or intraperitoneal administration of bleomycin. However, a difficulty presented by this traditional method is its high mortality rate of more than 50% after bleomycin administration. In this study, we aimed to establish a unilateral lung disease model and to assess its feasibility and usefulness. MATERIALS AND METHODS: After 6-week-old C57BL/6 mice were anesthetized, a 1.7Fr microcatheter was advanced into the trachea using an otoscope. Then, 1.0 mg/kg of bleomycin was injected into bilateral lung at the trachea (n=13) or unilateral lung (n=14) after advancing the microcatheter to the left main bronchus under fluoroscopy. Body weight change and survival of bilateral and unilateral lung disease group mice at day 28 were compared using Mann-Whitney and log-rank tests. Lungs were extracted and evaluated using Masson trichrome staining. RESULTS: Body weights decreased 75.7%±14.0% in the bilateral lung disease group, but were greater, 94.1%±11.4%, in the unilateral lung disease group (p=0.03). Overall survival rates at day 28 were 30.8% and 85.7% in the bilateral and unilateral lung disease groups, respectively. Survival was significantly better in the unilateral lung disease model (p=0.01). Histological evaluation confirmed collagen deposition only in the bleomycin injected lung in the unilateral lung disease model. CONCLUSION: Establishing both a healthy and a diseased lung in the same individual model was feasible, achieving lessened body weight loss and more favorable survival. This technique allows for a more efficacious research design, where both the efficacy and adverse effects of a pharmaceutical agent can be evaluated in a single animal.2025, In vivo (Athens, Greece), 39(1) (1), 251 - 256, English, International magazineScientific journal
- Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.Dec. 2024, Scientific reports, 14(1) (1), 31347 - 31347, English, International magazineScientific journal
- Lead, Nov. 2024, Liver Cancer, 1(26) (26)Gadoxetic Acid-Enhanced Magnetic Resonance Imaging Features Can Predict Immune-Excluded Phenotype of Hepatocellular Carcinoma
- BACKGROUND: Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancreatic cancer. In early pancreatic cancer, the tumor occasionally spreads laterally along the main pancreatic duct, presenting challenges in determining the extent of surgical resection. This study aimed to investigate the association of pancreatic atrophy pattern and intraductal cancer extension. METHODS: Thirty-two patients with early-stage pancreatic cancer who underwent surgery at five participating centers were enrolled. Pancreatic atrophy was defined as the narrowing of parenchyma compared to the surrounding parenchyma and was classified as either FPPA (partial atrophy surrounding the pancreatic duct stenosis) or UPA (global atrophy caudal to the site of duct stenosis). Intraductal cancer extension was defined as an extension exceeding 10 mm. RESULTS: Preoperative computed tomography revealed FPPA, UPA, and no parenchymal atrophy in 13, 13, and 6 patients. Cases with FPPA or UPA showed significantly longer cancer extensions than those without atrophy (P = 0.005 and P = 0.03, respectively). Intraductal cancer extension was present in all but one case of FPPA. 69% (9/13) of the cases with UPA showed intraductal cancer extension, whereas cases without atrophy showed no intraductal cancer extension. Importantly, two patients with FPPA or UPA showed positive resection margins during surgery and three patients with FPPA or UPA showed recurrence in the remnant pancreas. CONCLUSIONS: The presence of FPPA and UPA indicates lateral cancer extension in early-stage pancreatic cancer. Preoperative assessment of the pancreatic parenchyma may provide valuable insights for determining the extent of surgical resection.Sep. 2024, Journal of gastroenterology, English, Domestic magazineScientific journal
- PURPOSE: To compare the utility of thin-slice fat-suppressed single-shot T2-weighted imaging (T2WI) with deep learning image reconstruction (DLIR) and conventional fast spin-echo T2WI with DLIR for evaluating pancreatic protocol. METHODS: This retrospective study included 42 patients (mean age, 70.2 years) with pancreatic cancer who underwent gadoxetic acid-enhanced MRI. Three fat-suppressed T2WI, including conventional fast-spin echo with 6 mm thickness (FSE 6 mm), single-shot fast-spin echo with 6 mm and 3 mm thickness (SSFSE 6 mm and SSFSE 3 mm), were acquired for each patient. For quantitative analysis, the SNRs of the upper abdominal organs were calculated between images with and without DLIR. The pancreas-to-lesion contrast on DLIR images was also calculated. For qualitative analysis, two abdominal radiologists independently scored the image quality on a 5-point scale in the FSE 6 mm, SSFSE 6 mm, and SSFSE 3 mm with DLIR. RESULTS: The SNRs significantly improved among the three T2-weighted images with DLIR compared to those without DLIR in all patients (P < 0.001). The pancreas-to-lesion contrast of SSFSE 3 mm was higher than those of the FSE 6 mm (P < 0.001) and tended to be higher than SSFSE 6 mm (P = 0.07). SSFSE 3 mm had the highest image qualities regarding pancreas edge sharpness, pancreatic duct clarity, and overall image quality, followed by SSFSE 6 mm and FSE 6 mm (P < 0.0001). CONCLUSION: SSFSE 3 mm with DLIR demonstrated significant improvements in SNRs of the pancreas, pancreas-to-lesion contrast, and image quality more efficiently than did SSFSE 6 mm and FSE 6 mm. Thin-slice fat-suppressed single-shot T2WI with DLIR can be easily implemented for pancreatic MR protocol.Jun. 2024, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, English, Domestic magazineScientific journal
- BACKGROUND: This study aimed to examine whether the coefficient of variation (CV) in the hepatobiliary-phase (HBP) of Gd-EOB-DTPA-MRI could be an independent predictive factor for tumor progression. METHODS: Patients who underwent Gd-EOB-DTPA-MRI before Atezolizumab/bevacizumab therapy at six affiliated institutions between 2018 and 2022 were included. CV for each patient was calculated as the mean value for up to five tumors larger than 10 mm, and CV of the whole tumor was calculated using LIFEx software. The tumor response was evaluated within 6-10 weeks. The primary endpoint was to investigate the predictive factors, including CV, related to tumor progression using logistic regression analysis. The secondary endpoints were tumor response rate and progression-free survival (PFS) based on CV. RESULTS: Of the 46 enrolled patients, 13 (28.3%) underwent early progressive disease. Multivariate analysis revealed that a high CV (≥0.22) was an independent predictive factor for tumor progression (p = 0.043). Patients with a high CV had significantly frequent PD than those with a low CV (43.5 vs. 13.0%, p = 0.047). Patients with a high CV tended to have shorter PFS than those with a low CV (3.5 vs. 6.7 months, p = 0.071). CONCLUSION: Quantitative analysis using CV in the HBP of Gd-EOB-DTPA-MRI may be useful for predicting tumor progression for atezolizumab/bevacizumab therapy.Jun. 2024, Cancers, 16(12) (12), English, International magazineScientific journal
- This study investigated the utility of imaging features, such as rim enhancement on contrast-enhanced CT (CECT), in predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). This retrospective study included 158 patients (84 men; mean age, 68 years) with pathologically confirmed PDAC. The following imaging features were evaluated on CECT by two radiologists: tumor size, tumor attenuation, and the presence of rim enhancement. Cox proportional hazards analysis was performed to identify the imaging and clinicopathological features for predicting disease-free survival (DFS) and overall survival (OS). Pathological features were compared with the presence of rim enhancement. Among the 158 patients, 106 (67%) underwent curative surgery (surgery group) and 52 (33%) received conservative treatment (non-surgery group). Rim enhancement was observed more frequently in the non-surgery group than in the surgery group (44% vs. 20%; p < 0.001). Rim enhancement showed significant associations with shorter DFS and OS in the surgery group (hazard ratios (HRs), 3.03 and 2.99; p < 0.001 and p = 0.003, respectively), whereas tumor size showed significant associations with shorter OS (HR per 1 mm increase, 1.08; p < 0.001). PDACs with rim enhancement showed significant associations with higher histological tumor grades (p < 0.001). PDAC with rim enhancement on CECT could predict poorer prognosis and more aggressive tumor grades.MDPI AG, Apr. 2024, Diagnostics, 14(8) (8), 782 - 782Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2024, 日本インターベンショナルラジオロジー学会雑誌, 39(Suppl.) (Suppl.), 253 - 253, Japanese無再発のガン患者の血液中のexosome由来のmicroRNAのガン細胞増殖抑制作用
- We report a case of a life-threatening ruptured renal angiomyolipoma (AML) that did not meet the criteria for prophylactic treatment (tumor >4 cm or intratumoral aneurysm >5 mm) during follow-up. A woman in her 70s was followed up for a 2.5-cm AML with a rich vascular component. An intratumoral aneurysm >5 mm was not identified for 2 years. She complained of a sudden abdominal pain with hypotension, and contrast-enhanced computed tomography revealed a retroperitoneal hematoma with contrast media extravasation from an intratumoral aneurysm. Emergency transcatheter arterial embolization was successfully performed using N-butyl cyanoacrylate glue. Rupture can occur in small AMLs or in AMLs not identified with intratumoral aneurysms during follow-up. AMLs with a rich vascular component at the kidney surface are more likely to rupture.Mar. 2024, Interventional radiology (Higashimatsuyama-shi (Japan), 9(1) (1), 20 - 25, English, Domestic magazine
- AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.Feb. 2024, Hepatology research : the official journal of the Japan Society of Hepatology, English, International magazineScientific journal
- (公社)日本医学放射線学会, Feb. 2024, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 32 - 32, Japanese仙骨に発生した褐色脂肪腫の1例
- (一社)日本インターベンショナルラジオロジー学会, Jan. 2024, 日本インターベンショナルラジオロジー学会雑誌, 38(3) (3), 166 - 175, Japanese
- XMLink, 2024, Korean Journal of Radiology, 25(1) (1), 24 - 24Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Oct. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(1) (1), 16 - 23, Japanese
- PURPOSE: This study aimed to investigate the impact of transarterial embolization (TAE) on macrophage polarization and the modulatory effect of lenvatinib in combination with TAE in a rat hepatocellular carcinoma model. MATERIALS AND METHODS: A rat N1S1-bearing orthotopic model was subjected to TAE and administered 5 mg/kg of lenvatinib. CD8+, CD68+, and CD206+ cells were examined in four cohorts: sham (n=5), lenvatinib (n=5), TAE (n=5), and a combination of TAE and lenvatinib (n=5). Transcriptome analysis was performed to assess gene expression related to macrophage polarization in the sham, TAE, and combination groups. An in vitro co-culture experiment with bone marrow-derived macrophages was performed to identify lenvatinib target in macrophage polarization. RESULTS: There were no significant differences in the number of CD8+ and CD68+ cells among the four groups. Tumor-associated macrophage positivity for CD206 was significantly higher in the TAE group (58.1 ± 20.9) than in the sham (11.2 ± 14.3, P < 0.001) and combination (27.1 ± 19.7, P = 0.003) groups. In the transcriptome analysis, compared with those in the sham group, five macrophage polarization-related genes, including St6gal1, were upregulated by more than 1.5-fold in the TAE group and downregulated by more than 1.5-fold in the combination group. The co-culture experiment showed that lenvatinib did not affect macrophages but N1S1 cells, leading to macrophage polarization. CONCLUSION: TAE induced M2 macrophage polarization. Lenvatinib administration with TAE could reprogram macrophage polarization, improving tumor immune microenvironment.Jul. 2023, Journal of vascular and interventional radiology : JVIR, English, International magazineScientific journal
- Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.Jun. 2023, Surgery today, English, Domestic magazineScientific journal
- (一社)日本インターベンショナルラジオロジー学会, May 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(2) (2), 110 - 116, Japanese
- To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.Apr. 2023, Scientific reports, 13(1) (1), 6113 - 6113, English, International magazineScientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, English術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
- (一社)日本肝臓学会, Apr. 2023, 肝臓, 64(Suppl.1) (Suppl.1), A385 - A385, Japanese肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 140 - 140, Japanese有痛性脊椎転移に対する経皮的椎体形成術の有効性に関与する因子の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2023, 日本インターベンショナルラジオロジー学会雑誌, 38(Suppl.) (Suppl.), 175 - 175, English術前大動脈分枝塞栓術を併用したEVAR(EXCLUDER)の一年成績 多施設共同前向き研究(One-year results of EVAR(EXCLUDER) with side branch embolization: A prospective multicenter study)
- The incidence of hepatocellular carcinoma (HCC) is still on the rise in North America and Europe and is the second leading cause of cancer-related mortality. The treatment of HCC varies, with surgery and locoregional therapy (LRT) such as radiofrequency ablation and transcatheter arterial chemoembolization, and radiation therapy being the primary treatment. Currently, systemic therapy with molecular-targeted agents and immune checkpoint inhibitors (ICIs) is becoming a major treatment option for the unresectable HCC. As the HCC after LRT or systemic therapy often remains unchanged in size and shows loss of contrast effect in contrast-enhanced CT or MRI, the response evaluation criteria in solid tumors (RECIST) and World Health Organization criteria, which are usually used to evaluate the treatment response of solid tumors, are not appropriate for HCC. The modified RECIST (mRECIST) and the European Association for the Study of the Liver (EASL) criteria were developed for HCC, with a focus on viable lesions. The latest 2018 edition of the Liver Imaging Reporting and Data System (LI-RADS) also includes a section on the evaluation of treatment response. The cancer microenvironment influences the therapeutic efficacy of ICIs. Several studies have examined the utility of gadoxetic acid-enhanced MRI for predicting the pathological and molecular genetic patterns of HCC. In the future, it may be possible to stratify prognosis and predict treatment response prior to systemic therapy by using pre-treatment imaging findings.Apr. 2023, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 22(2) (2), 209 - 220, English, Domestic magazineScientific journal
- PURPOSE: To investigate the added value of contrast enhancement boost (CE-boost) images in multiphasic contrast-enhanced CT (CE-CT) for diagnosing small (<20 mm) hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included 69 patients (age, 74 ± 8 years; 52 men) with 70 hypervascular HCCs (<20 mm) who underwent multiphasic CE-CT (pre-contrast, late arterial phase [LAP], portal venous phase [PVP], and equilibrium phase). Two types of CE-boost images were generated by subtracting PVP from LAP (LA-PV) images and LAP from PVP (PV-LA) images to enhance the contrast effect of hepatic arterial and portal venous perfusion more selectively. Tumor-to-liver contrast-to-noise ratios (CNRs) in CE-boost images were compared with those in CE-CT images using the Wilcoxon signed-rank test. Two independent readers reviewed the imaging datasets: CE-CT alone and CE-CT with CE-boost images. The diagnostic performance of each dataset was compared using jackknife alternative free-response receiver operating characteristics (JAFROC-1). RESULTS: The tumor-to-liver CNRs in the LA-PV (6.4 ± 3.0) and PV-LA (-3.3 ± 2.1) images were greater than those in the LAP (3.2 ± 1.7) and PVP images (-1.1 ± 1.4) (p <.001 for both). The reader-averaged figures of merit were 0.751 for CE-CT alone and 0.807 for CE-CT with CE-boost images (p <.001). Sensitivities increased by adding CE-boost images for both readers (p <.001 and = 0.03), while positive predictive values were equivalent (p >.99). CONCLUSION: Adding CE-boost images to multiphasic CE-CT can improve the diagnostic accuracy and sensitivity for small hypervascular HCC by increasing the tumor-to-liver CNR.Mar. 2023, European journal of radiology, 160, 110696 - 110696, English, International magazineScientific journal
- (一社)日本インターベンショナルラジオロジー学会, Feb. 2023, 日本インターベンショナルラジオロジー学会雑誌, 37(1) (1), 2 - 12, Japanese
- 【Purpose】 To search for microRNAs that prevent cancer recurrence from exosomes in the blood of cancer patients undergoing IVR (Interventional Radiology), and to develop new nucleic acid drugs for cancer. 【Subjects】 Blood of recurrent and non-recurrent cancer patients after IVR, and healthy subjects. 【Methods】 Exosomes were extracted from the blood of cancer patients and healthy subjects, and RNA was purified. Furthermore, microRNA was detected by GeneChip miRNA 4.0 Array analysis. In addition, microRNA mimic was transfected into colon cancer cells (HCT116), and the viability of cancer cells was evaluated by Calcein/PI fluorescence staining. 【Results】 MicroRNA expression patterns were different in exosomes in the blood of recurrent cancer patients, non-recurrent cancer patients, and healthy subjects. Furthermore, we found 18 microRNAs with significantly more than 3-fold abundance in non-recurrent cancer patients. Among the 18 microRNA mimics, 3 microRNAs reduced cancer cell viability to less than 20%. 【Summary】 Since exosomal microRNA in the blood of non-recurrence-free cancer patients markedly decreased the viability of cancer cells, it is expected as a novel nucleic acid drug to prevent recurrence of cancer.Japanese Pharmacological Society, 2023, Proceedings for Annual Meeting of The Japanese Pharmacological Society, 97, 3-B-P-056, Japanese
- BACKGROUND: The kidneys are one of the organs most commonly affected by blunt trauma; however, the anatomical variations that predispose kidney injury are poorly understood. CASE PRESENTATION: An 80-year-old Japanese woman with lumber scoliosis was brought to our hospital because of severe flank pain after a minor fall at home. Contrast-enhanced computed tomography showed a severe left kidney laceration at the level of an acute angle in the vertebral column caused by scoliosis. Extravasation of contrast medium from the left renal artery branches was also noted. Selective arterial embolization achieved hemostasis. The patient was transferred to a rehabilitation facility without sequelae. CONCLUSION: Patients with scoliosis could be at higher risk of severe kidney laceration because of intrusion of the vertebral column into the retroperitoneal space. Therefore, even after low-impact trauma, active exploration for kidney injury could be warranted in patients with spinal curvature disorders.2023, Acute medicine & surgery, 10(1) (1), e816, English, International magazine
- Springer Science and Business Media LLC, Sep. 2022, European Radiology, 33(2) (2), 1388 - 1399Scientific journal
- BACKGROUND: Thyrocervical trunk rupture is an unusual, but critical, complication associated with central venous catheter (CVC) placement. The management of this complication has not been fully determined because it is rare. CASE PRESENTATION: A 53-year-old Japanese woman with anorexia nervosa developed refractory ventricular fibrillation. After returning spontaneous circulation, a CVC was successfully placed at the initial attempt in the right internal jugular vein using real-time ultrasound guidance. Immediately after CVC placement, she developed enlarging swelling around the neck. Contrast-enhanced computed tomography showed massive contrast media extravasation around the neck and mediastinum. Brachiocephalic artery angiography showed a "blush" appearance of the ruptured right thyrocervical trunk. After selective arterial embolization with 33% N-butyl-2-cyanoacrylate, the extravasation completely disappeared and hemostasis was achieved. CONCLUSION: Our findings suggest that severe vascular complications arising from CVC placement can occur in patients with a fragile physiological state. Endovascular embolization is an effective treatment for such complications.Sep. 2022, JA clinical reports, 8(1) (1), 74 - 74, English, International magazineScientific journal
- Springer Science and Business Media LLC, Sep. 2022, Clinical Journal of GastroenterologyScientific journal
- Abstract Background Spinal fractures rarely cause hemothorax, and no treatment consensus has been reached. Conservative treatment is generally selected in cases without arterial injury, but there have been some reports of uncontrolled bleeding. Here we report a case of hemothorax caused by spinal fracture without arterial injury treated with transcatheter arterial embolization. Case presentation An 88-year-old Japanese woman with back pain was diagnosed with hemothorax due to bleeding from an unstable fracture of the tenth thoracic vertebra. Contrast-enhanced computed tomography revealed no obvious arterial injury. We performed transcatheter arterial embolization of the bilateral tenth intercostal arteries to prevent rebleeding. The hemothorax did not worsen until surgical spinal fixation 9 days post-transcatheter arterial embolization, and she was discharged 30 days after admission. Conclusion Transcatheter arterial embolization for hemothorax caused by spinal fractures without obvious arterial injury may be a useful bridge to spinal fixation.Springer Science and Business Media LLC, Sep. 2022, Journal of Medical Case Reports, 16(1) (1)Scientific journal
- (公社)日本医学放射線学会, Sep. 2022, 日本医学放射線学会秋季臨床大会抄録集, 59回, S308 - S308, Japanese脈管奇形・リンパ管の画像診断と治療戦略(診断) 画像診断から判断する脈管奇形の治療戦略 形成外科医の立場から
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(3) (3), 244 - 253, Japanese【Intermediate stage HCCに対するTACE】TACEにおける腫瘍微小環境の変化と分子標的薬・免疫治療併用の意義
- Informa UK Limited, Aug. 2022, Journal of Hepatocellular Carcinoma, Volume 9, 695 - 705Scientific journal
- Portal vein thrombosis (PVT) is a lethal complication of hepatectomy if not properly treated. An 81-year-old woman diagnosed with postoperative PVT after right hepatectomy and caudate lobectomy for perihilar cholangiocarcinoma. Elevation of serum total bilirubin levels, D-dimer levels, and glossy ascites appeared on postoperative day 5 (POD5), and a contrast-enhanced CT confirmed PVT. Thrombi were found from the umbilical portion of the portal vein to the superior mesenteric vein. There were signs of acute liver failure due to thrombi obstructing the portal vein. Therefore, emergent catheter thrombus aspiration was performed under laparotomy. An aspiration catheter was inserted into the superior mesenteric vein from the ileocolic vein. We performed direct aspiration thrombectomy, followed by anticoagulant administration using urokinase via the catheter. Partial recanalization of the portal vein and superior mesenteric vein was observed. To dissolve residual thrombi, edoxaban administration was started on POD6. Contrast-enhanced CT 16 days after her additional operation showed the thrombi had completely disappeared. The patient was discharged on POD76. She had no recurrence of PVT over the next 6 months. Combination therapy of early intervention using aspiration catheter and systemic anticoagulant medication was useful for severe postoperative PVT accompanied with liver failure.Jun. 2022, Clinical journal of gastroenterology, 15(5) (5), 981 - 987, English, Domestic magazineScientific journal
- Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.May 2022, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, English, Domestic magazineScientific journal
- (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 238 - 238, Englishラット肝細胞癌モデルにおける塞栓によるマクロファージの極性転換はレンバチニブによってリプログラムされ得る(Embolization Induced Macrophage Polarization can be Reprogrammed by Lenvatinib in Rat Hepatoma Model)
- (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 271 - 271, EnglishエクスクルーダーによるEVAR前の予防的な大動脈側枝塞栓術 前向き多施設共同研究(Preemptive aortic side branch embolization before EVAR with EXCLUDER:A prospective multicenter study)
- (一社)日本インターベンショナルラジオロジー学会, May 2022, 日本インターベンショナルラジオロジー学会雑誌, 37(Suppl.) (Suppl.), 212 - 212, EnglishENDURANTによるEVAR前の大動脈側枝塞栓術の先取り 多施設共同プロスペクティブ研究(Preemptive aortic side branch embolization before EVAR with ENDURANT: A prospective multicenter study)
- (一社)日本インターベンショナルラジオロジー学会, Mar. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 200 - 200, Japanese光イメージングで視認可能な担癌ラットモデルの開発(第二報)
- (一社)日本インターベンショナルラジオロジー学会, Mar. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(2) (2), 194 - 194, JapaneseEVAR後の内腸骨動脈瘤をup-and-over techniqueを用いてExcluder IBEで治療した1例
- (株)Gakken, Mar. 2022, 画像診断, 42(4) (4), S106 - S119, Japanese
- Mar. 2022, EUROPEAN RADIOLOGY, 32(3) (3), 1770 - 1780, EnglishScientific journal
- (公社)日本医学放射線学会, Feb. 2022, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 39 - 39, Japanese123I-MIBGシンチグラフィで腎に異常集積を認めた腎動脈解離の1例
- (株)日本メディカルセンター, Feb. 2022, 臨床消化器内科, 37(3) (3), 304 - 310, Japanese
- Jan. 2022, JOURNAL OF MAGNETIC RESONANCE IMAGING, EnglishScientific journal
- PURPOSE: The purpose is to investigate the major and minor complications of the pancreas after transcatheter arterial embolization (TAE) using n-butyl-2-cyanoacrylate (NBCA) for bleeding from pancreatic arteries. MATERIALS AND METHODS: Thirty-three patients who underwent TAE using NBCA for acute bleeding from pancreatic arteries and their parent arteries followed by contrast-enhanced computed tomography (CE-CT) were evaluated retrospectively. Complications and risk factors were assessed using Mann-Whitney U test or Fisher's exact test for the univariate analysis. Patients' characteristic, embolized artery, procedure details, and clinical outcomes were examined as possible risk factors. RESULTS: TAE was performed successfully in all patients. Minor pancreatic complications occurred in 10 patients (30%), including acute mild pancreatitis (n = 4) and focal lack of pancreatic parenchymal enhancement on CE-CT without pancreatitis (n = 6). No cases of major pancreatic complications, such as moderate/severe pancreatitis, were reported. Embolized artery was the only significant risk factor. The rate of complications per embolized artery were 15% (three out of 20 patients) in the arteries of the pancreatic head and 54% (seven out of 13 patients) in the arteries of pancreatic body and tail (p = 0.025). CONCLUSION: TAE using NBCA for acute bleeding from pancreatic arteries is efficacious and safe. Mild pancreatic complications were observed more frequently in case of embolization of the pancreatic body and tail region than the pancreatic head.Oct. 2021, Japanese journal of radiology, 40(3) (3), 308 - 317, English, Domestic magazineScientific journal
- 医学図書出版(株), Sep. 2021, 胆と膵, 42(9) (9), 815 - 822, Japanese
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(1) (1), 82 - 98, Japanese
- 医学図書出版(株), Sep. 2021, 胆と膵, 42(9) (9), 815 - 822, Japanese
- (公社)日本医学放射線学会, Aug. 2021, 日本医学放射線学会秋季臨床大会抄録集, 57回, S464 - S464, Japanese逆チャンス型胸椎骨折による血胸の一例
- (一社)日本門脈圧亢進症学会, Aug. 2021, 日本門脈圧亢進症学会雑誌, 27(3) (3), 154 - 154, Englishラットモデルにおける門脈塞栓術 無水エタノールとn-butyl-cyanoacrylateの比較
- Background: Technological developments have led to an increased usage of external-body radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) may be required later in patients treated with RT because of the high recurrence rate and multinodular presentation of HCC. However, despite the risk of liver function impairment, the cumulative liver damage correlated with TACE following a hepatic RT has not been adequately assessed. Purpose: To evaluate the feasibility of TACE following RT for HCC. Materials and methods: Sixty-seven patients with HCC who underwent TACE after RT were retrospectively evaluated between 2012 and 2018. We assessed increases in Child-Turcotte-Pugh (CTP) by ≥2 points at 1 month, the incidence of major complications, survival duration, and short-term mortality within 6 months after TACE. Furthermore, we evaluated the predictive factors for liver function impairment and short-term mortality. Results: Eight patients experienced a CTP increase ≥2 points at 1 month. There were no cases of liver abscesses or bilomas. Nine patients died within 6 months following TACE. The mean liver dose (MLD) was a significant predictor of liver function impairment at 1 month (p = 0.042). Low liver functional reserve, distant metastasis (p = 0.037), MLD (p = 0.046), TACE type (p = 0.025), and TACE within 3 months following RT (p = 0.007) were significant predictors of short-term mortality. Conclusions: Despite the feasibility of TACE following RT, clinicians should pay attention to impaired pretreatment liver function, following high dose RT, and the short duration between RT and TACE.Jul. 2021, Acta radiologica open, 10(7) (7), 20584601211034965 - 20584601211034965, English, International magazineScientific journal
- Jul. 2021, EMERGENCY RADIOLOGY, 28(6) (6), 1127 - 1133, EnglishScientific journal
- Jun. 2021, BIOELECTRICITY, 3(3) (3), 204 - 214, EnglishScientific journal
- Japan Society of Hepatology, May 2021, Kanzo, 62(5) (5), 229 - 239Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 125 - 125, Japanese大動脈疾患に対するIVR治療の現況と課題 EVARの遠隔期成績向上への取り組み
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 160 - 160, JapaneseShaggy aorta症例における上腸間膜動脈バルーンプロテクション併用下TEVARの有用性の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 191 - 191, JapaneseウサギVX2腫瘍モデルを用いた過酸化チタンナノ粒子動注の基礎的研究
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 201 - 201, English上顎癌動注化学療法における腫瘍進展方向と栄養血管に関する検討(Tumor extension and feeding arteries in intraarterial chemotherapy for maxillary cancer)
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 251 - 251, Japanese陰部腟静脈瘤に対し血管内治療を行った1例
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2021, 日本インターベンショナルラジオロジー学会雑誌, 36(Suppl.) (Suppl.), 172 - 172, English門脈塞栓術後肝肥大 ラットモデルを用いた無水エタノールとn-butyl-cyanoacrylate glueの比較(Portal vein embolization: In vivo comparison of ethanol and n-butyl-cyanoacrylate in a rat model)
- (公社)日本小児科学会, Apr. 2021, 日本小児科学会雑誌, 125(4) (4), 674 - 674, Japanese微小肺病変に対する胸腔鏡補助下肺部分切除術においてCTガイド下マーキングが有用であった1例
- (株)メジカルビュー社, Apr. 2021, 臨床画像, 37(4) (4), 490 - 497, Japanese
- Mar. 2021, Oncology Letters, 21(3) (3), 207 - 207, English, International magazineScientific journal
- (一社)日本血管内治療学会, 2021, 日本血管内治療学会誌, 22(1) (1), 50 - 53, Japanese【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
- (一社)日本血管内治療学会, 2021, 日本血管内治療学会誌, 22(1) (1), 50 - 53, Japanese【血管内治療における抗血栓療法】外傷性・医原性血管損傷に対するバイアバーン留置後の抗血栓療法
- Jan. 2021, CardioVascular and Interventional Radiology, 44(1) (1), 150 - 155, English, International magazineScientific journal
- BACKGROUND: Postoperative biliary strictures are commonly related to accidental bile duct injuries or occur at the site of biliary anastomosis. The first-line treatment for benign biliary strictures is endoscopic therapy, which is less invasive and repeatable. However, recanalization for biliary complete obstruction is technically challenging to treat. The present report describes a successful case of treatment by extraluminal recanalization for postoperative biliary obstruction using a transseptal needle. CASE PRESENTATION: A 66-year-old woman had undergone caudal lobectomy for the treatment of hepatocellular carcinoma. The posterior segmental branch of the bile duct was injured and repaired intraoperatively. Three months after the surgery, the patient had developed biliary leakage from the right hepatic bile duct, resulting in complete biliary obstruction. Since intraluminal recanalization with conventional endoscopic and percutaneous approaches with a guidewire failed, extraluminal recanalization using a transseptal needle with an internal lumen via percutaneous approach was performed under fluoroscopic guidance. The left lateral inferior segmental duct was punctured, and an 8-F transseptal sheath was introduced into the ostium of right hepatic duct. A transseptal needle was advanced, and the right hepatic duct was punctured by targeting an inflated balloon that was placed at the end of the obstructed right hepatic bile duct. After confirming successful puncture using contrast agent injected through the internal lumen of the needle, a 0.014-in. guidewire was advanced into the right hepatic duct. Finally, an 8.5-F internal-external biliary drainage tube was successfully placed without complications. One month after the procedure, the drainage tube was replaced with a 10.2-F drainage tube to dilate the created tract. Subsequent endoscopic internalization was performed 5 months after the procedure. At the 1-year follow-up examination, there was no sign of biliary obstruction and recurrence of hepatocellular carcinoma. CONCLUSIONS: Recanalization using a transseptal needle can be an alternative technique for rigid biliary obstruction when conventional techniques fail.Dec. 2020, Surgical case reports, 6(1) (1), 304 - 304, English, International magazineScientific journal
- (公社)日本医学放射線学会, Oct. 2020, 日本医学放射線学会秋季臨床大会抄録集, 56回, S144 - S144, Japanese治療適応の基準を満たさない腎血管筋脂肪腫の破裂
- Sep. 2020, European Journal of Radiology, 130Scientific journal
- Sep. 2020, Journal of Vascular and Interventional Radiology, 31(9) (9), 1475 - 1482.e2, English, International magazineScientific journal
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 122 - 122, Japanese液体塞栓物質(NBCA)を極める! エキスパートへの道 膵領域の急性出血に対するNBCAを用いた動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 131 - 131, Japanese骨転移疼痛に対する集学的治療 -この痛みをどう治療するか- 骨転移に対する骨セメント治療 経皮的椎体形成術の適応を考える
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 133 - 133, Japanese大動脈解離に対するIVR 大動脈解離に対するIVRの現況と課題
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2020, 日本インターベンショナルラジオロジー学会雑誌, 35(Suppl.) (Suppl.), 282 - 282, Japaneseドセタキセル含浸薬剤溶出性ビーズの基礎的検討
- Aug. 2020, JGH Open, 4(4) (4), 677 - 683[Refereed]Scientific journal
- (公社)日本小児科学会, Jun. 2020, 日本小児科学会雑誌, 124(6) (6), 1038 - 1038, Japanese新生児マススクリーニングにて高ガラクトース血症を指摘された先天性門脈体循環シャントの1例
- May 2020, CardioVascular and Interventional Radiology, 43(5) (5), 696 - 705, English, International magazine[Refereed]Scientific journal
- May 2020, European Journal of Radiology, 126, 108861 - 108861, English, International magazine[Refereed]Scientific journal
- Jan. 2020, Journal of computer assisted tomography, 44(1) (1), 153 - 159[Refereed]Scientific journal
- Lead, Jan. 2020, Liver Cancer, 9(1) (1), 63 - 72, English, International magazine[Refereed]Scientific journal
- Sep. 2019, Journal of Gastroenterology and Hepatology (Australia), 34(9) (9), 1648 - 1655, English, International magazine[Refereed]Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 77 - 77, Japanese細径ラジオ波電極針の開発と凝固範囲の検討
- Jul. 2019, American journal of physiology. Renal physiology, 317(7) (7), F52 - F64, Co-authored internationally[Refereed]
- May 2019, Diagnostic and Interventional Imaging, 100(5) (5), 279 - 285, English, Co-authored internationally[Refereed]Scientific journal
- Apr. 2019, Japanese Journal of Radiology, 37(4) (4), 328 - 335, English, Domestic magazine[Refereed]Scientific journal
- Apr. 2019, CardioVascular and Interventional Radiology, 42(4) (4), 505 - 512, English[Refereed]Scientific journal
- Apr. 2019, CardioVascular and Interventional Radiology, 42(4) (4), 542 - 551, English[Refereed]Scientific journal
- Nov. 2018, International Journal of Hyperthermia, 34(8) (8), 1186 - 1193, Co-authored internationallyScientific journal
- (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 317, Japanese光イメージングで視認可能な担癌ラットモデルの開発(第一報)
- Jun. 2018, Cryobiology, 82, 106 - 111, English, Co-authored internationally[Refereed]Scientific journal
- Jun. 2018, Japanese Journal of Radiology, 36(6) (6), 394 - 400, English, Domestic magazine[Refereed]Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, May 2018, IVR: Interventional Radiology, 33(1) (1), 66 - 66, Japanese低酸素刺激が免疫抑制因子発現に与える影響について ラット肝細胞癌株による検討
- May 2018, Journal of Thoracic and Cardiovascular Surgery, 155(5) (5), 2150 - 2159.e3, Co-authored internationally[Refereed]Scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 190 - 190, English右副腎静脈を確認するための副腎静脈サンプリング中血管造影CTの有用性(The utility of Angio-CT during adrenal venous sampling to confirm the right adrenal vein)
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 191 - 191, English血管過多性脊髄腫瘍の部分切除のための術前塞栓術の実行可能性(The feasibility of preoperative embolization for partial resection of hypervascular spinal tumor)
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 227 - 227, English膵および膵周囲動脈の急性出血に対するNBCA塞栓術(Embolization with NBCA for acute bleeding of pancreatic and peripancreatic arteries)
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 238 - 238, English血管内腹部大動脈修復(EVAR)後のII型エンドリーク塞栓術の長期転帰(Long-term outcome of type II endoleak embolization after endovascular abdominal aortic repair (EVAR))
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2018, IVR: Interventional Radiology, 33(Suppl.) (Suppl.), 239 - 239, English下腸間膜動脈閉塞を伴うEVAR後の2型エンドリークの予測因子(Predictive factors of type 2 endoleaks after EVAR with occluded inferior mesenteric artery)
- Apr. 2018, Int J Hyperther, 18, 1 - 8, English, Co-authored internationally[Refereed]Scientific journal
- Jan. 2018, Gastrointestinal Endoscopy, 87(1) (1), 300.e1 - 300.e6, English, Co-authored internationally[Refereed]Scientific journal
- Aug. 2017, Handbook of Electroporation, 1, 761 - 776, Co-authored internationallyIn book
- Aug. 2017, International Journal of Oncology, 51(2) (2), 695 - 701, English, International magazine[Refereed]Scientific journal
- Aug. 2014, Japanese Journal of Radiology, 32(8) (8), 487 - 490, English, Domestic magazine[Refereed]Scientific journal
- Apr. 2014, CardioVascular and Interventional Radiology, 37(2) (2), 348 - 354, English, International magazine[Refereed]Scientific journal
- Feb. 2014, Annals of Vascular Surgery, 28(2) (2), 490.e13 - 490.e16, English, International magazine[Refereed]Scientific journal
- 2014, Journal of Vascular and Interventional Radiology, 25(3) (3), 469 - 476, English, International magazine[Refereed]Scientific journal
- 2014, Journal of Vascular and Interventional Radiology, 25(11) (11), 1809 - 1815, English, International magazine[Refereed]Scientific journal
- (一社)日本外科学会, Mar. 2013, 日本外科学会雑誌, 114(臨増2) (臨増2), 737 - 737, Japanese大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点 IFU外症例に対するステントグラフト内挿術の治療成績Research society
- May 2012, Journal of Vascular Surgery, 55(5) (5), 1410 - 1418, English, International magazine[Refereed]Scientific journal
- 2008, Japanese Journal of Clinical Radiology, 53(8) (8), 977 - 986Endovascular treatment for pulmonary thromboembolism and deep vein thrombosisScientific journal
- 克誠堂出版(株), Jan. 2024, 形成外科, 67(1) (1), 43 - 47, Japanese
- (一社)日本インターベンショナルラジオロジー学会, Dec. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(4) (4), 365 - 401, Japanese
- (一社)日本インターベンショナルラジオロジー学会, Dec. 2022, 日本インターベンショナルラジオロジー学会雑誌, 36(4) (4), 365 - 401, Japanese
- 2022, 日本インターベンショナルラジオロジー学会雑誌(Web), 36(2) (2)光イメージングで視認可能な担癌ラットモデルの開発:第二報
- (一社)日本インターベンショナルラジオロジー学会, Feb. 2021, 日本インターベンショナルラジオロジー学会雑誌, 35(3) (3), 290 - 309, Japanese
- 2021, 日本門脈圧亢進症学会雑誌, 27(3) (3)ラットモデルにおける門脈塞栓術(無水エタノールとn-butyl-cyanoacrylateの比較)
- (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S140 - S140, Japanese当院における脾動脈瘤に対する動脈塞栓術の治療成績
- (一社)日本脈管学会, Oct. 2019, 脈管学, 59(Suppl.) (Suppl.), S175 - S175, JapaneseIliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(1) (1), 79 - 79, Japanese直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 239 - 239, Japanese当院における経腟分娩後の産道出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 255 - 255, JapaneseIliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 259 - 259, Japanese当院における大動脈解離に対するTEVARの治療成績
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 314 - 314, JapaneseCTで認識できない骨病変に対するCTガイド下骨生検の検討
- (一社)日本インターベンショナルラジオロジー学会, May 2019, 日本インターベンショナルラジオロジー学会雑誌, 34(Suppl.) (Suppl.), 226 - 226, Japanese肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討
- 2019, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)細径ラジオ波電極針の開発と凝固範囲の検討
- 2019, 脈管学(Web), 59(supplement) (supplement)当院における脾動脈瘤に対する動脈塞栓術の治療成績
- 2019, 脈管学(Web), 59(supplement) (supplement)Iliac Branch Endoprosthesisを用いたステントグラフト内挿術の初期成績
- 2019, 日本インターベンショナルラジオロジー学会雑誌(Web), 34(1) (1)直腸静脈瘤に対して上直腸静脈直接穿刺法で塞栓術を行った1例
- (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 317, Japanese肝動脈塞栓術がTGF-β発現に与える影響 ラット肝癌モデルによる検討
- (一社)日本インターベンショナルラジオロジー学会, Nov. 2018, IVR: Interventional Radiology, 33(3) (3), 317 - 318, Japanese破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した1例
- (一社)日本脈管学会, Sep. 2018, 脈管学, 58(Suppl.) (Suppl.), S107 - S107, Japanese中長期成績からみた腹部大動脈瘤ステントグラフトの功罪 IMA閉塞例におけるEVAR後のType 2エンドリークの検討 予防的IMA塞栓術は有用か?
- (一社)日本インターベンショナルラジオロジー学会, May 2018, IVR: Interventional Radiology, 33(1) (1), 66 - 66, Japanese低酸素刺激がサイトカイン産生に与える影響 ラット肝細胞癌株による検討
- 2018, 脈管学(Web), 58(supplement) (supplement)IMA閉塞例におけるEVAR後のType2エンドリークの検討:予防的IMA塞栓術は有用か?
- (一社)日本脈管学会, Oct. 2017, 脈管学, 57(Suppl.) (Suppl.), S109 - S109, Japanese内臓動脈瘤の血管内治療 内臓動脈瘤に対する血管内治療の経験
- Jul. 2017, Metallic Stentの現状と進歩XVII, 32, 20 - 21, Japanese空腸動脈瘤の塞栓術後に正中弓状靭帯の圧迫による副駆動脈起始部狭窄に対してステントを留置した1例[Invited]Report scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 164 - 164, Japanese腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 180 - 180, Japanese動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 236 - 236, Japanese十二指腸静脈瘤に対するB-RTOの有効性の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 243 - 243, Japanese炎症性腹部大動脈瘤に対するステントグラフト内挿入術(EVAR)の治療成績
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 244 - 244, JapaneseEVAR後にopen conversionに至った症例の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2017, IVR: Interventional Radiology, 32(Suppl.) (Suppl.), 246 - 246, JapaneseEndurantステントグラフトによるEVARの中長期成績
- (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S137 - S137, JapaneseEVAR後の遅発性type 1bエンドリークの危険因子に関する検討
- (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S167 - S167, JapaneseEndurantステントグラフトによるEVARの中長期成績
- (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S188 - S189, Japanese左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypell endoleak塞栓を繰り返した1例
- (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S189 - S189, JapaneseEVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
- (一社)日本脈管学会, Oct. 2016, 脈管学, 56(Suppl.) (Suppl.), S207 - S207, Japanese上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2016, IVR: Interventional Radiology, 31(3) (3), 266 - 266, Japaneseハイブリッド手術システムを用いたIVR 非大血管疾患における臨床応用
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2016, IVR: Interventional Radiology, 31(3) (3), 267 - 267, Japanese左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にType II endoleak塞栓を繰り返した1例
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 178 - 178, Japanese予防的IMA塞栓術を施行したENDURANT Stentgraft Systemを用いたEVARの治療成績
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 178 - 178, JapaneseEVAR後の遅発性Type 1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 189 - 189, Japanese大動脈・末梢動脈疾患に対する救急IVR 神戸大学病院における取り組みとその応用
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 182 - 182, JapaneseTAEとデノスマブ投与の併用が奏功した仙骨巨細胞腫の1例
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2016, IVR: Interventional Radiology, 31(2) (2), 129 - 135, Japanese【ハイブリッド手術室システムの応用-外科手術とIVRのコラボレーション-】 ハイブリッド手術室システムの臨床応用 神戸大学病院における大血管以外多領域での臨床応用の取り組み[Refereed][Invited]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 113 - 113, Japaneseビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 131 - 131, JapaneseEVAR後のDistal sealing zoneの形態変化と遅発性type 1bエンドリークの危険因子に関する検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 135 - 135, JapaneseEndurantステントグラフトによるEVARの中長期成績
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 136 - 136, JapaneseEndurantステントグラフトを用いたEVARにおける予防的IMA塞栓群・非塞栓群の比較・検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2016, IVR: Interventional Radiology, 31(Suppl.) (Suppl.), 174 - 174, Japaneseブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討
- (公社)日本医学放射線学会, Feb. 2016, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 53 - 53, Japanese腎部分切除術後に腎動脈 腎杯瘻を来しTAEにて治療し得た1例
- 2016, 脈管学(Web), 56(supplement) (supplement), S189(J‐STAGE), JapaneseEVAR後の遅発性Type1a endoleakに対し瘤内塞栓術およびAortic cuff留置術にて治療した1例
- 2016, 脈管学(Web), 56(supplement) (supplement), S188‐S189(J‐STAGE), Japanese左総腸骨動脈閉塞を伴う腹部大動脈瘤に対するEVAR後にTypeII endoleak塞栓を繰り返した1例
- 2016, 脈管学(Web), 56(supplement) (supplement), S167(J‐STAGE), JapaneseEndurantステントグラフトによるEVARの中長期成績
- 2016, 脈管学(Web), 56(supplement) (supplement), S137(J‐STAGE), JapaneseEVAR後の遅発性type1bエンドリークの危険因子に関する検討
- 2016, 脈管学(Web), 56(supplement) (supplement), S207(J‐STAGE), Japanese上腸間膜動脈急性閉塞に対しフォガティースルールーメンカテーテルを用いて血栓除去を行った一例
- (一社)日本脈管学会, Oct. 2015, 脈管学, 55(Suppl.) (Suppl.), S131 - S131, Japanese予防的IMA塞栓術を併施したENDURANT Stentgraft Systemを用いたEVARの治療成績
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 275 - 275, Japanese当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期治療成績
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 277 - 277, Japanese前下膵十二指腸動脈瘤破裂により十二指腸水平脚に高度狭窄を来たした1例
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 284 - 284, Japanese前置・癒着胎盤の帝王切開時におけるIVR ハイブリッド手術室を利用した新たな治療戦略
- (一社)日本インターベンショナルラジオロジー学会, Sep. 2015, IVR: Interventional Radiology, 30(3) (3), 286 - 286, Japanese異時性に発症した両側特発性腸骨動脈解離の1例
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2015, IVR: Interventional Radiology, 30(2) (2), 166 - 171, Japanese門脈圧亢進症 PTO、TIOなど[Refereed]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Dec. 2014, IVR: Interventional Radiology, 29(4) (4), 435 - 435, Japanese内腸骨動脈空置瘤に対して経動脈的塞栓術を施行した2例
- 産業開発機構(株), Aug. 2014, 映像情報Medical, 46(8) (8), 732 - 737, Japanese【腹部Interventional Radiologyの手技とコツ】 腹部外傷に対するIVR[Invited]Introduction commerce magazine
- (一社)日本インターベンショナルラジオロジー学会, Aug. 2014, IVR: Interventional Radiology, 29(3) (3), 252 - 257, Japanese【NBCA塞栓術の現状と病理組織学的影響】 NBCA塞栓術の現状と病理組織学的影響 膵臓[Invited]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 219 - 219, Japanese巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 223 - 223, Japanese当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 188 - 194, Japanese外傷IVRの基本と応用 脾損傷[Invited]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Jun. 2014, IVR: Interventional Radiology, 29(2) (2), 140 - 146, Japanese【非外傷性出血のIVR】 非外傷性の特発性後腹膜出血[Invited]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 153 - 153, Japanese周産期出血に対する子宮動脈塞栓術における子宮動脈造影所見の検討
- (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 176 - 176, Japanese鈍的胸部大動脈損傷に対する企業性ステントグラフトを用いたTEVARの現状
- (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 194 - 194, Japanese急性下肢動脈閉塞に対するFogarty Thru-Lumen catheterを用いた選択的血栓除去術の治療成績の検討
- (一社)日本インターベンショナルラジオロジー学会, May 2014, IVR: Interventional Radiology, 29(Suppl.) (Suppl.), 204 - 204, JapaneseEVAR後Type II Endoleak残存症例に対する追加治療の成績
- (一社)日本インターベンショナルラジオロジー学会, Feb. 2014, IVR: Interventional Radiology, 29(1) (1), 34 - 42, Japanese【救急疾患に対するIVR】 泌尿器科領域の救急疾患に対するIVR[Invited]Introduction scientific journal
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 103 - 103, Japanese内臓動脈瘤に対するIVR 孤立性内腸骨動脈瘤に対する血管内治療の長期成績
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 105 - 105, Japanese出血に対するIVR 非外傷性特発性後腹膜出血に対する動脈塞栓術の検討
- (一社)日本インターベンショナルラジオロジー学会, Apr. 2013, IVR: Interventional Radiology, 28(Suppl.) (Suppl.), 173 - 173, Japanese当院における危機的産科出血に対する子宮動脈塞栓術の治療成績
- (一社)日本インターベンショナルラジオロジー学会, May 2011, IVR: Interventional Radiology, 26(2) (2), 221 - 225, Japanese透析バスキュラーアクセス 透析シャント機能不全に対するIVR その適応と限界 閉塞例を中心に
- (公社)日本医学放射線学会, Feb. 2009, 日本医学放射線学会学術集会抄録集, 68回, S351 - S351, Japanese主経路慢性閉塞を伴う透析シャント不全に対するPTAの治療成績
- (公社)日本医学放射線学会, Sep. 2008, 日本医学放射線学会秋季臨床大会抄録集, 44回, S521 - S521, Japanese下横隔動脈が関与していた外傷性血胸の1例
- 金原出版(株), Aug. 2008, 臨床放射線, 53(8) (8), 977 - 986, Japanese【肺血栓塞栓症のIVR治療に必要な画像診断とテクニック】肺血栓塞栓症と深部静脈血栓症のIVR治療
- Others, Springer, 2017, EnglishHandbook of Electroporation / Medical Imaging of ElectroporationScholarly book
- SAMI2023, Jul. 2023免疫療法時代のIVR基礎研究と画像診断[Invited]
- 第39回日本DDS学会学術集会, Jul. 2023肝動脈塞栓療法(TACE)による癌微小環境の変化[Invited]
- 第29回 先端医用画像研究会, Jul. 2023複合免疫治療時代の肝細胞癌 画像診断・IVRの役割[Invited]
- 第48回 播淡画像研究会, Jun. 2023Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~[Invited]
- 肝類洞壁細胞研究会, Dec. 2022Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~[Invited]
- 第44回播但画像診断研究会, Jun. 2021TACEが癌微小環境に与える影響[Invited]
- 第219回 関西アンギオIVRカンファレンス, Feb. 2020, Japanese肝悪性腫瘍の画像診断[Invited]Public discourse
- IVR Expert Meeting, Jan. 2020, JapaneseLenvatinib+TACEの有用性 〜基礎的研究の観点から〜[Invited]Public discourse
- 第22回 大阪神戸腹部画像診断・IVR医学研究会, Dec. 2019, Japanese, Domestic conferenceIVRと癌微小環境[Invited]Invited oral presentation
- Society of Interventional Oncology, Jun. 2019, Japanese, International conferenceHepatic Artery Embolization enhances the expressions of TGF-β1 and HIF-1α in a rat hepatoma modelOral presentation
- 第19回関西肝癌局所療法研究会, Mar. 2019, Japanese, Domestic conference肝細胞癌に対する放射線照射治療後の経動脈的化学塞栓療法の安全性の検討Oral presentation
- 第1回宮崎関西放射線研究会, Feb. 2019, Japanese, Domestic conference肝動脈塞栓術は免疫抑制性サイトカイン発現に与える影響 -ラット肝癌モデルによる検討-[Invited]Invited oral presentation
- The 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA2018), Nov. 2018, English, Chicago, International conferenceUtility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic FibrosisPoster presentation
- 第71回 兵庫県医師会医学会, Oct. 2018, Japanese, Domestic conference地域に生かす最新癌治療[Invited]Public discourse
- 第53回 兵庫県放射線医会総会, Oct. 2018, Japanese, Domestic conference困ったときに役立つIVR[Invited]Public discourse
- 第59回日本脈管学会総会, Oct. 2018, Japanese, 広島, Domestic conferenceIMA閉塞例におけるEVAR後のType2エンドリークの検討 予防的IMA塞栓術は有用か?Public symposium
- 第65回関西IVR研究会, Jun. 2018, Japanese, 大阪, Domestic conference破裂性十二指腸静脈瘤に対してバルーン閉塞下逆行性静脈瘤塞栓術を施行した一例Oral presentation
- 第65回関西IVR研究会, Jun. 2018, Japanese, 大阪, Domestic conference肝動脈塞栓術がTGF-β発現に与える影響:ラット肝癌モデルによる検討Oral presentation
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conferenceThe feasibility of preoperative embolization for partial resection of hypervascular spinal tumorOral presentation
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conferenceEmbolization with NBCA for acute bleeding from pancreatic and peripancreatic arteriesOral presentation
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conferenceTGF-β1 blockade does not enhance immunomodulatory benefit of partial IRE in murine bladder tumorOral presentation
- The Joint Meeting of the 47th Meeting of the Japanese Society of Interventional Radiology & The 13th Meeting of the International Symposium of Interventional Radiology, May 2018, English, JSIR & ISIR, Tokyo, Japan, International conferencePredictive factors of type 2 endoleaks after EVAR with occluded inferior mesenteric arteryOral presentation
- SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conferenceTransforming growth factor-β1 blockade after irreversible electroporation of murine urothelial tumor does not provide additional survival or cancer control benefits.[Invited]Oral presentation
- SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conferenceThe Effects of Partial Irreversible Electroporation (IRE) on T-cell and Macrophage Population in Murine Bladder Tumor Microenvironment[Invited]Poster presentation
- SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conferenceSparing of Collagen and Extracellular Matrix Proteins in Irreversible Electroporation Treated Normal Porcine Lung Promotes T-cell and Macrophage Infiltration Throughout Ablated Tissue[Invited]Public discourse
- SIR2018, Mar. 2018, English, Society of Interventional Radiology, Los Angels, USA, International conferenceHypoxic stress induces the overexpression of programmed death ligand 1 and chemokine ligand 17 on rat hepatoma cell lines[Invited]Oral presentation
- 第63回中部IVR・第64回関西IVR合同研究会, Feb. 2018, Japanese, 中部IVR・関西IVR合同研究会, 愛知, Domestic conference低酸素刺激がサイトカイン産生に与える影響:ラット肝細胞癌株による検討[Invited]Oral presentation
- 第58回日本脈管学会総会, Oct. 2017, Japanese, 日本脈管学会, 名古屋, Domestic conference内臓動脈瘤の血管内治療 内臓動脈瘤に対する血管内治療の経験Public symposium
- CIRSE (Cardiovascular and Interventional Radiological Society of Europe) Annual Scientific Meeting, Sep. 2017, English, CIRSE, Copenhagen, Denmark, International conferenceBalloon-occluded retrograde transvenous obliteration for duodenal varices.[Invited]Poster presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference動脈塞栓術を施行した腎部分切除術後の仮性動脈瘤の検討[Invited]Oral presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference十二指腸静脈瘤に対するB-RTOの有効性の検討[Invited]Oral presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference腫瘍性脊椎圧骨折に対する経皮的椎体形成術の検討[Invited]Oral presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conference炎症性腹部大動脈瘤に対するステントグラフト内挿入術(EVAR)の治療成績[Invited]Oral presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conferenceEVAR後にopen conversionに至った症例の検討[Invited]Oral presentation
- The 46th Annual Meeting of the Japanese Society of Interventional Radiology, May 2017, Japanese, Japanese society of interventional radiology, 岡山, 【目的】Endurant○Rステントグラフトを用いた腹部大動脈瘤(AAA)に対するステントグラフト内挿術(EVAR)の中長期成績を検討すること。【方法】対象は2012年から2016年に神戸大学病院および関連施設でAAAに対してEndurant○Rを用いたEVARが施行され、6か月以上の観察を行った134例。(男性118例、年齢は75.1±8.5歳、大動脈瘤最大短径は平均52.4±7.7mm、IFU内症例は89例(66%))後方視的に動脈瘤サイズ変化、エンドリーク(EL)、動脈瘤関連の再治療について検討した。【結果】全134例の平均観察期間は19±11月で、経過観察中の全死亡例は6例(4.5%)であったが、動脈瘤関連死はなかった。動脈瘤のサイズ変化は瘤縮小(5mm以上)50例(37%)、不変79例(59%)、拡大(5mm以上)5例(4%)であった。経過, Domestic conferenceMid-long term results of endovascular abdominal aortic aneurysm repair with Endurant stent graft system[Invited]Oral presentation
- 第46回日本IVR学会総会, May 2017, Japanese, 日本IVR学会, 岡山, Domestic conferenceEndurantステントグラフトによるEVARの中長期成績[Invited]Poster presentation
- Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conferenceEmbolization for spontaneous adrenal hemorrhage.[Invited]Oral presentation
- Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conferenceDouble balloon-occluded retrograde transvenous obliteration (BRTO) using a pull-through technique for the treatment of duodenal varices with two draining veins.[Invited]Oral presentation
- Cardiovascular and Interventional Radiological Society of Europe, Sep. 2016, English, Cardiovascular and Interventional Radiological Society of Europe, Barcelona, Spain, International conferenceCombination therapy using denosumab and transarterial embolization for symptomatic sacral giant cell tumor.[Invited]Oral presentation
- The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conferenceブタ肝後面下大静脈損傷モデルを用いたステントグラフトによる止血効果の検討[Invited]Oral presentation
- The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conferenceビーズ導入後のTACEの現状 多発肝細胞癌に対する非選択的DEB-TACEの有用性の検討[Invited]Oral presentation
- The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conferenceEVAR後のDistal sealing zoneの形態変化と遅発性type 1bエンドリークの危険因子に関する検討[Invited]Oral presentation
- The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conferenceEndurantステントグラフトを用いたEVARにおける予防的IMA塞栓群・非塞栓群の比較・検討[Invited]Oral presentation
- The Annual Meeting of Japanese Society of Interventional Radiology, May 2016, Japanese, Japanese Society of Interventional Radiology, 名古屋, Domestic conferenceEndurantステントグラフトによるEVARの中長期成績[Invited]Oral presentation
- The 12th Asia-Pacific Congress of Cardiovascular and Interventional Radiology, Apr. 2016, English, Asia-Pacific society of Cardiovascular and Interventional Radiology, Suzhou, CHINA, International conferenceAngiographic classification of uterine artery may predict failure of UAE for postpartum hemorrhage[Invited]Oral presentation
- 第59回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference内腸骨動脈空置瘤に対して経動脈的塞栓術を施行した2例Oral presentation
- 第60回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference当院における薬剤溶出性球状塞栓物質を用いたTACE(DEB-TACE)の初期経験Oral presentation
- 第61回関西IVR研究会, 2015, Japanese, 日本IVR学会, 大阪, Domestic conference前下膵十二指腸動脈瘤破裂により十二指腸水平脚に高度狭窄を来した一例Oral presentation
- 第59回関西IVR研究会, 2014, Japanese, 日本IVR学会, 大阪, Domestic conference当院における非外傷性特発性後腹膜出血に対する動脈塞栓術の検討Oral presentation
- 第58回関西IVR研究会, 2014, Japanese, 日本IVR学会, 大阪, Domestic conference巨細胞動脈炎の関与が疑われる両側上腕動脈病変に対しPTAを施行した2例Oral presentation
- 16th Congress Asian Society for Vascular Surgery (ASVS) and 9th Asian Venous Forum, 2014, English, Asian Society for Vascular Surgery (ASVS), 香港, 中国, International conferenceManagement of type II endoleak after endovascular repair of arteriocaval fistula complicating aortoiliac aneurysm: case report and literature review[Invited]Poster presentation
- 関西IVR地方会, Jun. 2013, Japanese, 関西IVR学会, 大阪, Domestic conference腹腔動脈起始部狭窄に伴う下膵十二指腸動脈瘤破裂に対するTAE後に十二指腸狭窄をきたした1例[Invited]Oral presentation
- The 113rd Annual Congress of Japan Surgical Society, Apr. 2013, Japanese, The Japan Surgical Society, 福岡, Domestic conference腹部大動脈瘤に対するステントグラフト内挿術の適応拡大における問題点[Invited]Oral presentation
- 日本IVR学会第33回関西地方会, Feb. 2013, Japanese, 日本IVR学会, 大阪, Domestic conference鎖骨下静脈からの中心静脈カテーテル挿入に伴う胸肩峰動脈損傷に対して動脈塞栓術を施行した2例[Invited]Oral presentation
- 第38回日本IVR学会総会, Aug. 2009, Japanese, 日本IVR学会, 大阪, Domestic conference外傷性胸部大動脈損傷に対するMatsui-Kitamuraステントグラフト留置術の有用性[Invited]Oral presentation
- 第48回 播淡画像研究会Lenvatinibが塞栓術後の癌微小環境中の免疫状態に与える影響~Rat肝癌モデルによる検討~[Invited]
- 日本肝癌研究会
- The Japan Society of Hepatology
- Japanese Society of Interventional Radiology
- JAPAN RADIOLOGICAL SOCIETY
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2023 - 31 Mar. 2026ドライバー遺伝子に基づくTACE治療反応性の血清バイオマーカーの開発
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2023 - 31 Mar. 2026Development of non-invasive biomarker to predict therapeutic efficacy of immunotherapy for hepatocellular carcinoma
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2026深部臓器発生の悪性腫瘍に対する新規放射線増感療法としての飽和炭酸水動注療法の開発
- 公益社団法人 ひょうご科学技術協会, 学術研究助成, Apr. 2025 - Mar. 2026, Principal investigator肝細胞癌に対するTACE治療効果を予測する血清バイオマーカー開発
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 01 Apr. 2022 - 31 Mar. 2025人工知能を用いた膵癌CT自動診断システム開発とスクリーニング・早期診断への応用腹部造影CT画像に対して画像AI技術を用い、膵腫瘤および膵癌に付随する頻度の高い二次所見(主膵管拡張、主膵管狭窄、膵萎縮)の自動検出による膵癌自動診断システムの構築を試みた。深層学習を用いて、膵実質、膵管、腫瘤の各領域を自動抽出し、抽出結果に基づき膵腫瘤性病変ならびに二次所見の有無を判定可能なAIエンジンを構築した。トレーニングセット・バリデーションセットとして膵癌群587例、対照群432例を用い、テストデータとして関連施設より収集した膵癌群62例、対照群90症例を対象に、膵腫瘤検出AI単独による膵癌検出精度ならびに膵腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出精度を評価・算出した。 テストデータにおける腫瘤検出AIのみによる膵癌検出能は、感度73.3%、特異度96.7%であった。腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出能は、感度93.5%、特異度84.4%であった。二次所見検出AIを組み合わせることにより検出感度が向上するとともに、腫瘤検出AI単独では検出できなかったTisやT1等の小膵癌に対しても検出成功例が増加した。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2020 - 31 Mar. 2023肝動脈塞栓術後のガン微小環境におけるマクロファージ極性制御に基づく新規治療戦略luciferase遺伝子導入N1S1ラット肝癌細胞を用いて同種移植肝癌モデルを作成した。腫瘍移植後7日目に頸動脈より細経のマイクロカテーテルを挿入し、肝動脈 を選択し、破砕したゼラチン物質にて腫瘍動脈の塞栓術を行った。さらに1週間後にIVISにて腫瘍壊死および残存組織の発光をIVISにて確認した。その後、 Sacrificeを行い、肝癌移植・辺縁部をまとめて摘出し、mRNA抽出を行い、microarrayによる網羅的遺伝子解析を行った。TAE群ではTAMに関与する遺伝子群の発現が増加傾向にあり、これらはLenvatinib併用群では減少する傾向にあった。TAEにより生じた腫瘍免疫微小環境のTAM増加に向かう変化がLenvatinibにより修正されうる可能性が示唆された。さらにラット脛骨より骨髄細胞を採取し、M-CSF投与によりマクロファージへと分化させ た。同骨髄由来マクロファージとN1S1細胞を用いてマクロファージ極性変化を評価した。Lenvatinibとマクロファージのみに投与しても極性変化は見られなかっ たが、N1S1のConditioned mediumを加えるとマクロファージ極性変化が生じ、Lenvatinib投与により改善が見られた。よって、Lenvatinibはマクロファージに作 用するのではなく、腫瘍細胞に作用し、その結果、腫瘍より放出されるサイトカインによりマクロファージ極性変化が生じることが予想された。 以上の結果をまとめて、関連学会にて報告、英文校正を経て関連学会雑誌に投稿中である。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 01 Apr. 2019 - 31 Mar. 2022ヨードマップを用いた膵癌の線維性間質定量による悪性度および治療抵抗性の予測法確立本研究の目的はDual-Energy CTで撮像したダイナミック造影CTから得られるヨードマップを用いて膵癌内部の線維性間質の多寡を定量測定することにより、非侵襲的に膵癌の悪性度ならびに治療抵抗性の予測を行うことである. 最終目的の前の先行研究として、膵癌線維化マーカーであるCollagen fiberならびに活性化膵星細胞と予後との関連を後方視的に評価した。2008年から2017年の間に神戸大学病院において膵癌に対して手術加療が行われた通常型膵管癌162症例に対してCollagen量を評価するEVG染色、活性化膵星細胞を評価するα-SMA染色を行った。それぞれの全体における染色割合をPhotoshopで算出し、その多寡で予後を評価した所、Collagen fiberが高度な膵癌は軽度な膵癌と比較して生存率が有意に延長(Log-rank test P=0.001)、α-SMA陽性細胞が高度の膵癌は軽度な膵癌と比較して生存率が有意に延長していた(Log-rank test P=0.001)。また線維化高度な膵癌では腫瘍内のCD8陽性T細胞が多いことも判明した。この結果から、膵癌においては線維化が高度な症例で予後が良く、腫瘍内免疫状態とも関連している可能性が示唆された。 続いて、上記対象162膵癌に対して造影CT平衡相画像から線維化を予測可能かを評価した。線維化予測指標としてECV fractionを利用して18例において評価を行った所、ECV fractionとCollagen fiberの程度に中等度の相関が見られたが(ρ=0.641、P=0.034)、α-SMA陽性細胞との程度には相関は認められなかった(ρ=0.352、P=0.289)。造影CT平衡相における評価は検討症例数を増やすとともに、ヒストグラム解析の追加を検討している。 また、Dual-Energy CTを用いた膵癌線維性間質の評価を行うための研究に対して倫理委委員会の承認が得られ、実施体制を整えることができた。
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2017 - 31 Mar. 2021Transarterial infusion of metallic nanoparticles for radiation therapy enhancementTwelve female rabbits with VX2 thigh tumors were divided into the three groups: Intraarterial (IA), balloon occlusion arterial (BOA), and intravenous (IV) infusion groups. 10 ml of PAA-TiOx NPs (10 mg/ml) were infused through an external iliac artery in the IA and BOA groups and a marginal ear vein in the IV group. The median accumulation rates of PAA-TiOx NPs in VX2 tumor were 0.119, 0.078 and 0.117 weight percent, and the median concentration of NPs in VX2 tumor was 0.0026, 0.0015, and 0.0034 mg/g tissue in the IA, BOA and IV groups, respectively. There were no statistically differences between the IA and IV groups, and nor between the BOA and IV groups. PAA-TiOx NPs accumulated most in liver at 10.9306, 16.2188 and 25.7768 weight percent, and second most in spleen at 0.8686, 0.7624 and 2.4372 weight percent in the IA, BOA and IV groups. Intraarterial infusion did not increase the accumulation of PAA-TiOx NPs in VX2 tumor compared with intravenous infusion.
- 兵庫県健康財団, 癌研究奨励賞, Jul. 2019 - Jun. 2020, Principal investigator肝癌局所療法後に生じる免疫抑制性サイトカイン産生メカニズムの解明および阻害法の探索Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2017 - 31 Mar. 2019Rats bearing N1S1 hepatoma cells underwent HAE. Animals were euthanized at 48h, and liver tissues were harvested. IHC and qPCR were performed to compare the expression of TGF-β1. In vitro experiments with the N1S1 cell line were performed under hypoxic conditions for 48h, and the expression of TGF-β1 and HIF-1α was assessed with western blotting and ELISA. IHC showed that both the TGF-β1 and HIF-1α-positive areas were larger in the HAE group than in the sham group. Similarly, qPCR showed that the mRNA expression levels of TGF-β1 and HIF-1α were higher in the HAE group than those in the sham group. TGF-β1 expression was suppressed when HIF-1α inhibitors were added, and HIF-1α expression was upregulated when exogenous TGF-β1 was added in N1S1 cells.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2016 - 31 Mar. 2019This study aimed to evaluate the efficacy of an intra-arterially infused carbon dioxide (CO2)-saturated solution in sensitizing the anti-cancer effect of cisplatin in a rabbit VX2 liver tumor model. Forty VX2 liver tumor-bearing Japanese white rabbits were randomly divided into four groups and infused via the hepatic artery with a saline solution (control group, CO2 group, cisplatin group, and combined group). The tumor growth ratios were calculated on days 3 and 7. Hypoxia (HIF-1α) and apoptosis (cleaved caspase-3) were evaluated on day 7. The tumor growth ratio was significantly lower in the CO2 group than in the control group (day 3), and in the combined group than in the cisplatin group (days 3 and 7). HIF-1α suppression and increased cleaved caspase-3 expression were detected in the CO2 and combined groups, compared with the other two groups. An intra-arterially infused CO2-saturated solution inhibits liver VX2 tumor growth and sensitizes the anti-cancer effect of cisplatin.Competitive research funding
- 日本医学放射線学会, 2018年度Bayer研究助成受賞, Apr. 2018 - Mar. 2019, Principal investigator肝細胞癌に対するレンバチニブとTACE併用療法:ラット肝癌モデルを用いた検討Competitive research funding
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Kobe University, 01 Apr. 2013 - 31 Mar. 2016The current study has been conducted aiming at developing a new endovascular treatment for traumatic juxtahepatic inferior vena cava injury. In spite of an experiment conducted at first for developing new balloon catheter using a swine, any effective inferior vena cava perfusion was not obtained and we were forced to change the shape. At the second stage, we have successfully established a swine juxtahepatic inferior vena cava injury model which had not been reported up to now. In an examination continuously performed on whether hemostasis is possible or not by endovascular treatment for the injury model, a hemostatic effect was observed using endografts. Therefore, we have advanced a development of new removable device with hemostatic effect equivalent of endograft. At the final stage of improvement work for the device as of now, we have been conducting additional experiments aiming at earlier completion.
- Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Kobe University, 01 Apr. 2013 - 31 Mar. 2015, Principal investigatorIt is important to make the new method of aortic aneurysm model in order to find out the new treatment for aortic aneurysm. We had the experiments of making the aortic aneurysm model with the catheter which is a narrow tube. As a result, we could make the aortic aneurysm model. However, it was very low rate to make the aneurysm model and the shapes were irregular. It was not useful as an aortic anerysm model.Competitive research funding