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松本 賢亮
医学部附属病院 循環器内科
准教授

研究者基本情報

■ 学位
  • 博士（医学）, 神戸大学
■ 研究分野
  • ライフサイエンス / 循環器内科学

研究活動情報

■ 受賞
  • 2016年08月 欧州心臓病学会（ESC）, 欧州心臓病学会Best Poster賞, ポスター発表
    松本賢亮
    国際学会・会議・シンポジウム等の賞

  • 2011年04月 日本心エコー図学会, 海外学会論文賞, 海外学会発表者
    松本賢亮
    国内学会・会議・シンポジウム等の賞

■ 論文
  • Koji Kashiki, Kensuke Matsumoto, Akitoshi Yamada, Satoru Kawasaki, Hogara Nishisaki
    2026年06月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Tetsu Yamazaki, Kensuke Matsumoto, Masahiko Hoshijima, Satoru Kawasaki, Hogara Nishisaki
    2025年10月, European Heart Journal - Cardiovascular Imaging
    研究論文（学術雑誌）

  • Akari Odagi, Kensuke Matsumoto, Tetsu Yamazaki, Satoru Kawasaki, Hogara Nishisaki
    2025年10月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Shinnosuke Tsukamoto, Kensuke Matsumoto, Tomohiro Hayashi, Akitaka Yamada, Satoru Kawasaki
    2025年08月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Manami Shingu, Kensuke Matsumoto, Tetsu Yamazaki, Satoru Kawasaki, Hogara Nishisaki
    2025年05月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Manami Shingu, Kensuke Matsumoto, Masahiko Hoshijima, Satoru Kawasaki, Hogara Nishisaki
    2024年08月, European Heart Journal - Cardiovascular Imaging
    研究論文（学術雑誌）

  • Ryo Matsunuma, Takashi Yamaguchi, Kensuke Matsumoto, Akihiro Sakashita, Chikako Hashiguchi, Masashi Iida, Yoshiyuki Kizawa
    This study sought to explore the unmet palliative care needs of patients diagnosed with Stage B chronic heart failure (CHF) according to the American Heart Association (AHA) and American College of Cardiology (ACC) classifications. We conducted this cross-sectional study between June 1 and August 31, 2020, at Kobe University Hospital. Patients were asked to complete the Integrated Palliative care Outcome Scale (IPOS) along with a customized questionnaire developed by a multidisciplinary team. These tools were filled out by the patients themselves or with help from family members. A total of 101 patients participated in the study, with 55 of them (55%) falling into the Stage B CHF group as classified by AHA/ACC. Among the physical symptoms, 22% reported dyspnea and 20% reported drowsiness as common concerns. Regarding specific problems, 47% identified issues related to exercise, 62% with eating, 26% with finances, and 18% with employment. Notably, financial difficulties were found to be significantly more common among Stage B patients when compared to those in Stages C and D (odds ratio [OR]: 5.22; 95% confidence interval [95% CI]: 1.03-26.5; p = 0.032). Almost 79% of Stage B patients expressed a desire to understand the progression of their disease. In conclusion, stage B CHF patients may face financial difficulties and have unmet informational needs. Therefore, further research is necessary to explore these aspects in greater detail.
    2024年, Indian journal of palliative care, 30(4) (4), 384 - 387, 英語, 国際誌
    研究論文（学術雑誌）

  • Yuhna Fujimoto, Kensuke Matsumoto, Yu Mizutani, Satoru Kawasaki
    2023年07月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Arisa Senda, Kensuke Matsumoto, Masahiko Hoshijima, Satoru Kawasaki
    2023年07月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Kana Fujita, Kensuke Matsumoto, Atsuhiko Kishi, Satoru Kawasaki
    2022年12月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Mitsuru Takami, Koji Fukuzawa, Kunihiko Kiuchi, Kensuke Matsumoto, Yu Izawa, Ken-Ichi Hirata
    The management of heart rhythm disorders in patients with adult congenital heart disease and limited vascular access is challenging. We present the case of a 38-year-old woman with Ebstein's anomaly who underwent implantation of a combination of a leadless pacemaker and a subcutaneous implantable cardioverter-defibrillator to manage fatal arrhythmias. (Level of Difficulty: Intermediate.).
    2022年12月, JACC. Case reports, 4(23) (23), 101464 - 101464, 英語, 国際誌
    研究論文（学術雑誌）

  • Ayu Shono, Kensuke Matsumoto, Nao Ishii, Kenya Kusunose, Makiko Suzuki, Nao Shibata, Makiko Suto, Kumiko Dokuni, Mitsuru Takami, Kunihiko Kiuchi, Koji Fukuzawa, Hidekazu Tanaka, Ken-Ichi Hirata
    This study sought to assess the left atrial (LA) functional recovery after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) and to evaluate the determining factor of procedural success of RFCA, using a novel preload stress echocardiography. A total of 111 patients with AF were prospectively recruited. The echocardiographic parameters were obtained during the leg-positive pressure (LPP) maneuver, both at baseline and midterm after RFCA. As an index of LA distensibility, the LA expansion index was calculated as (LAVmax - LAVmin) × 100 / LAVmin. During a median follow-up period of 14.2 months, AF recurrence was observed in 23 patients (20.7%). In LA functional parameters at baseline, only the Δ LA expansion index was significantly larger in the success group (16 ± 11% vs 4 ± 9%, p <0.05). At midterm follow-up, the Δ LA expansion index significantly increased to 32 ± 19% (p <0.05), together with structural LA reverse remodeling only in the success group. Moreover, the Δ stroke volume index during the LPP stress test significantly increased only in the success group (from 2.3 ± 1.3 ml/m2 to 3.1 ± 4.8 ml/m2, p <0.05). In a multivariate analysis, left ventricular ejection fraction (hazard ratio 0.911, p <0.05) and baseline Δ LA expansion index (hazard ratio 0.827, p <0.001) were independent predictors of AF recurrence. In conclusion, the baseline Δ LA expansion index during LPP stress is a reliable marker for predicting procedural success after RFCA. Moreover, maintenance of sinus rhythm resulted in an improvement of the preload reserve after RFCA.
    2022年10月, The American journal of cardiology, 181, 59 - 65, 英語, 国際誌
    研究論文（学術雑誌）

  • Takahiro Kunigita, Kensuke Matsumoto, Satoru Kawasaki, Hogara Nishisaki
    2022年08月, European Heart Journal - Case Reports
    研究論文（学術雑誌）

  • Hiroaki Shiraki, Hidekazu Tanaka, Yuki Yamauchi, Yuko Yoshigai, Kentaro Yamashita, Yusuke Tanaka, Keiko Sumimoto, Ayu Shono, Makiko Suzuki, Shun Yokota, Kensuke Matsumoto, Koji Fukuzawa, Ken-Ichi Hirata
    We investigated the characteristics of patients with non-valvular atrial fibrillation (NVAF) and left atrial (LA) appendage (LAA) thrombus who had been given appropriate oral anticoagulation therapy. We studied 737 NVAF patients who were scheduled for catheter ablation or electrical cardioversion. All patients received appropriate oral anticoagulation therapy for at least 3 weeks prior to echocardiography in accordance with the guidelines. Whether LAA thrombus was present or absent on transesophageal echocardiography (TEE) was determined by at least three senior echocardiologists. LAA thrombi were observed in 22 patients (3.0%). Multivariate logistic regression analysis showed that LAA flow and LA volume index were both independent predictors of LAA thrombus formation; however, LAA flow (≤ 18 cm/s) was indicated as a more powerful predictor. Moreover, the prevalence of LAA thrombus formation in patients with NVAF without LA enlargement (LA volume index ≤ 34 mL/m2) was extremely rare (0.4%). LAA thrombus formation in patients with a mildly dilated LA volume index of 34-49.9 mL/m2 and paroxysmal AF was also extremely rare (0.0%). LAA flow is strongly associated with LAA thrombus formation, even in NVAF patients treated with appropriate oral anticoagulation therapy. Augmented oral anticoagulation therapy or transcatheter or surgical LAA closure should be considered for such patients, especially for those with an LAA flow < 18 cm/s. Furthermore, TEE for evaluating LAA thrombus before catheter ablation or electrical cardioversion may be unnecessary for NVAF patients who are undergoing appropriate oral anticoagulation therapy, depending on LA size.
    2022年05月, The international journal of cardiovascular imaging, 38(5) (5), 941 - 951, 英語, 国際誌
    研究論文（学術雑誌）

  • Nao Ishii, Kenya Kusunose, Ayu Shono, Kensuke Matsumoto, Susumu Nishio, Natsumi Yamaguchi, Yukina Hirata, Tomomi Matsuura, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
    The effects of catheter ablation on exercise tolerance and quality of life in patients with atrial fibrillation (AF) have been reported. We assessed cardiac function in more detail using the leg positive pressure (LPP) technique and found that contractile reserve is particularly important in relation to exercise tolerance and prognosis. In this study, we used the LPP technique to examine changes in contractile reserve immediately after ablation and 6 months later. We prospectively enrolled patients who underwent catheter ablation for AF at 2 institutes. We performed LPP stress echocardiography 2 to 3 days after (FU-1) and 6 months after (FU-2) ablation to examine changes in cardiac function indexes. The primary end point was improvement in contractile reserve. Ultimately, 109 patients (mean age 67.4 ± 9.6 years; 70% men) underwent 2 sessions of LPP stress echocardiography. The median CHA2DS2-VASC score was 2 (interquartile range 13). From FU-1 to FU-2, the change in the stroke volume index after the LPP maneuver increased in patients with paroxysmal and persistent AF with low CHA2DS2-VASC scores (both p <0.05). Regardless of AF subtype, contractile reserve at FU-2 improved in patients with low CHA2DS2-VASC scores compared with that at FU-1. In contrast, patients with high CHA2DS2-VASC scores had no change. In conclusion, patients with AF with a low CHA2DS2-VASC score had improved contractile reserve after ablation, whereas patients with high scores did not show any improvement. Aggressive interventions in patients with high scores may lead to better management after catheter ablation.
    2022年04月, The American journal of cardiology, 168, 71 - 77, 英語, 国際誌
    研究論文（学術雑誌）

  • Yoichi Takaya, Teiji Akagi, Ichiro Sakamoto, Hideaki Kanazawa, Gaku Nakazawa, Tsutomu Murakami, Atsushi Yao, Mamoru Nanasato, Mike Saji, Mitsugu Hirokami, Yasushi Fuku, Shinobu Hosokawa, Norio Tada, Kensuke Matsumoto, Masao Imai, Koji Nakagawa, Hiroshi Ito

    Objective

    Therapeutic strategies for atrial septal defect (ASD) with severe pulmonary arterial hypertension (PAH) are controversial. This study aimed to evaluate the efficacy of PAH-specific medications and subsequent transcatheter closure (ie, treat-and-repair strategy) on clinical outcomes.

    Methods

    We enrolled 42 patients who were referred to 13 institutions for consideration of ASD closure with concomitant PAH and underwent the treat-and-repair strategy. The endpoint was cardiovascular death or hospitalisation due to heart failure or exacerbated PAH.

    Results

    At baseline prior to PAH-specific medications, pulmonary to systemic blood flow ratio (Qp:Qs), pulmonary vascular resistance (PVR), and mean pulmonary artery pressure (PAP) were 1.9±0.8, 6.9±3.2 Wood units and 45±15 mm Hg. Qp:Qs was increased to 2.4±1.2, and PVR and mean PAP were decreased to 4.0±1.5 Wood units and 35±9 mm Hg at the time of transcatheter ASD closure after PAH-specific medications. Transcatheter ASD closure was performed without any complications. During a median follow-up period of 33 months (1-126 months) after transcatheter ASD closure, one older patient died and one patient was hospitalised due to heart failure, but the other patients survived with an improvement in WHO functional class. PAP was further decreased after transcatheter ASD closure.

    Conclusions

    The treat-and-repair strategy results in low complication and mortality rates with a reduction in PAP in selected patients with ASD complicated with PAH who have a favourable response of medical therapy.
    2022年03月, Heart (British Cardiac Society), 108(5) (5), 382 - 387, 英語, 国際誌
    研究論文（学術雑誌）

  • Ryo Matsunuma, Kensuke Matsumoto, Takashi Yamaguchi, Akihiro Sakashita, Yoshiyuki Kizawa
    Background: The type and frequency of palliative care needs of chronic heart failure (CHF) patients have not been determined in Japan. Objectives: The aim of this study was to comprehensively assess the prevalence and characteristics of palliative care needs of CHF outpatients. Methods: Patients were recruited for this cross-sectional study from June 1 to August 31, 2020, at the Kobe University Hospital. An Integrated Palliative care Outcome Scale (IPOS) and an original questionnaire developed by multidisciplinary experts were answered once by patients themselves or with the assistance of their family. Results: A total of 101 patients (63 males and 38 females) were included. The most common distressing symptoms were dyspnea (29%; 95% confidence interval [CI] 21-39]), drowsiness (29%; 95% CI 21-39), poor mobility (25%; 95% CI 17-35), insomnia (25%; 95% CI 17-35), and anxiety (24%; 95% CI 17-35). Eighty percent (95% CI 70-87) of patients were willing to have an end-of-life (EOL) discussion. When we compared New York Heart Association class I/II with III/IV patients, the frequency of distressing symptoms was associated with the severity of the disease, but both groups exhibited a willingness for having an EOL discussion or knowing the future course of their diseases. Conclusions: Dyspnea, drowsiness, insomnia, and anxiety were frequent symptoms in CHF outpatients in Japan. Beyond distressing symptoms, most ambulatory heart failure patients have a need for EOL discussion, which was not associated with disease stage. Assessing comprehensive and multidimensional palliative care needs, including needs for EOL discussion, is advisable among outpatients with CHF.
    2022年, Palliative medicine reports, 3(1) (1), 65 - 74, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suzuki, Kensuke Matsumoto, Yu Izawa, Ken-Ichi Hirata
    BACKGROUND: Although the life expectancy of patients with tetralogy of Fallot (TOF) is comparable to that of the general population due to advancements in surgical intervention, if untreated, patients with TOF may die during their childhood. However, it has been anecdotally reported that a small number of patients with unrepaired TOF survived into their senescence. CASE SUMMARY: A 71-year-old man with a history of multiple heart failure admissions was referred to our institute after successful cardiopulmonary arrest resuscitation. Transthoracic echocardiography showed the overriding of the aorta on a large ventricular septal defect and right ventricular hypertrophy, along with severe pulmonary stenosis (PS), all of which indicated unrepaired TOF. Computed tomography revealed a patent Blalock-Taussig shunt, which was constructed at the age of 19 years. Coronary angiography revealed multivessel coronary stenoses. Although radical intracardiac repair was not performed due to his multiple comorbidities, his heart failure symptoms were significantly improved owing to proper medication titration. One year following discharge, the patient was well and enjoyed playing golf. DISCUSSION: Specific anatomical, functional, and haemodynamic characteristics may be required for the long-term survival of patients with TOF. Pulmonary stenosis should be initially mild to guarantee pulmonary flow during childhood and adolescence, and gradual PS exacerbation should be paralleled with systemic-to-pulmonary collateral development or an extracardiac shunt. Moreover, reduced left ventricular compliance may act as a balancing factor against a right-to-left shunt. The presence of all of these special requirements may have contributed to the unusual survival for this patient.
    2021年12月, European heart journal. Case reports, 5(12) (12), ytab486, 英語, 国際誌
    研究論文（学術雑誌）

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Daisuke Terashita, Akira Nagasawa, Kousuke Tanimura, Kensuke Matsumoto, Hidekazu Tanaka, Ken-ichi Hirata
    John Wiley and Sons Inc, 2021年11月, Catheterization and Cardiovascular Interventions, 98(5) (5), E715 - E723, 英語
    研究論文（学術雑誌）

  • 東堂 沙紀, 松本 賢亮, 藤田 紘, 三和 圭介, 伊澤 有, 小林 成美, 平田 健一
    症例は76歳，女性．計3度の胸椎圧迫骨折ののち，徐々に座位時の呼吸困難感を訴えるようになった．このため，次第に日常生活活動度も低下するようになり，呼吸困難の原因精査のため当院入院となった．経胸壁心エコー図検査を施行したところ，仰臥位では明らかな短絡は認められなかったものの，座位時には超音波コントラスト剤による左心系の染影が確認された．卵円孔開存を基礎としたplatypnea-orthodeoxia syndromeが強く疑われたため，引き続き経食道心エコー図検査を施行．座位への体位変換により大きく開大する卵円孔開存の存在が確認され，同部を介した多量のコントラスト剤の左房流入を確認することができた．経皮的卵円孔閉鎖術を実施したところ，術後は呼吸困難および低酸素血症は消失した．本症例は，卵円孔開存の存在に加えて胸椎圧迫骨折を繰り返したことで亀背が進行し，その結果蛇行した大動脈が心房中隔を変形させ，右左短絡が形成されplatypnea-orthodeoxia syndromeを呈するに至ったものと考えられた．
    公益財団法人 日本心臓財団, 2021年10月, 心臓, 53(10) (10), 1118 - 1123, 日本語

  • Nao Shibata, Kensuke Katsumoto, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Yusuke Tanaka, Kentaro Yamashita, Shun Yokota, Makiko Suto, Kumiko Dokuni, Hidekazu Tanaka, Ken-ichi Hirata
    2021年08月, ESC Heart Failure
    研究論文（学術雑誌）

  • Ayu Shono, Kensuke Matsumoto, Nao Yamada, Kenya Kusunose, Makiko Suzuki, Keiko Sumimoto, Yusuke Tanaka, Kentaro Yamashita, Nao Shibata, Shun Yokota, Makiko Suto, Kumiko Dokuni, Hidekazu Tanaka, Ken-ichi Hirata
    Springer Science and Business Media B.V., 2021年08月, International Journal of Cardiovascular Imaging, 37(8) (8), 2473 - 2482, 英語
    研究論文（学術雑誌）

  • Hiroshi Fujita, Kensuke Matsumoto, Keisuke Miwa, Ken-ichi Hirata
    Elsevier Ltd, 2021年07月, Journal of Cardiology Cases, 24(1) (1), 37 - 40, 英語
    研究論文（学術雑誌）

  • Takuo Emoto, Tomohiro Hayashi, Tokiko Tabata, Tomoya Yamashita, Hikaru Watanabe, Tomoya Takahashi, Yasuhiro Gotoh, Kenjiro Kami, Naofumi Yoshida, Yoshihiro Saito, Hidekazu Tanaka, Kensuke Matsumoto, Tetsuya Hayashi, Takuji Yamada, Ken-Ichi Hirata
    BACKGROUND: We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using 16S rRNA gene amplicon analysis. Although a metagenome-wide analysis showed that choline-TMA lyase levels increased in HF patients, which TMA generation pathway from choline, carnitine, or betaine contributes to the increase in TMAO levels in HF needs to be elucidated. METHODS: We conducted a metagenome-wide shotgun sequencing analysis of gut microbiota and measured the TMAO levels in plasma of 22 HF patients during the compensated phase and 11 age-, sex-, and comorbidity-matched control subjects, whose gut microbiota compositions were reported in a previous 16S rRNA-based analysis. RESULTS: The abundance of cntA/B was positively correlated with TMAO, especially in HF patients, whereas that of cutC/D or betaine reductase was not correlated either in controls or HF patients. The abundance of cntA/B was mainly derived from the genera Escherichia and Klebsiella either in controls or HF patients. CONCLUSION: TMAO levels in plasma depend on the abundance of cntA/B in HF. Although it is difficult to exclude the involvement of confounding factors, microbial dysbiosis connecting the abundance of cntA/B in the gut and the increase of TMAO in plasma can be a therapeutic target for HF.
    2021年06月, International journal of cardiology, 338, 138 - 142, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Makiko Suzuki, Kensuke Matsumoto, Yusuke Tanaka, Kentaro Yamashita, Ayu Shono, Keiko Sumimoto, Nao Shibata, Shun Yokota, Makiko Suto, Kumiko Dokuni, Hidekazu Tanaka, Hiromasa Otake, Ken-Ichi Hirata
    PURPOSES: The closure of atrial septal defect (ASD) is associated with a significant reduction in right ventricular (RV) overload and an improvement in functional capacity in most adults with ASD. However, a subset of patients remains symptomatic even after closure due to therapeutic delay. To date, no clinically robust preoperative predictor of postoperative residual symptoms has been clearly identified. METHODS: In this study, 120 adult patients with ASD and 39 controls were investigated. As an index of RV myocardial deformation, RV global longitudinal strain (RV-GLS) was evaluated. The degree of coupling between RV and pulmonary artery (PA) was quantified by the tricuspid annular plane systolic excursion (TAPSE) divided by the PA systolic pressure (PASP). RESULTS: Compared to controls, baseline RV-GLS was significantly greater (- 27 ± 7 vs. - 23 ± 5%, P = 0.02) and TAPSE/PASP ratio was severely impaired (0.8 ± 0.3 vs. 2.1 ± 1.6 mm/mmHg, P < 0.01) in ASD patients. At 6 months after closure, 15 patients (12.5%) remained symptomatic. In patients without residual symptoms, TAPSE/PASP ratio significantly improved from 0.9 ± 0.3 to 1.0 ± 0.6 mm/mmHg (P = 0.02), and RV-GLS normalized (from - 28 ± 11 to - 24 ± 7%, P < 0.01) after closure. However, RV-GLS and TAPSE/PASP ratio showed no significant change in ASD patients with residual symptoms. On multivariate analysis, preoperative TAPSE/PASP ratio (odds ratio [OR] 0.034, 95% confidence interval [CI] 0.000-0.604, P = 0.03) and pulmonary vascular resistance index ([PVRI], OR 1.011, 95% CI 1.000-1.021, P < 0.05) were associated with the postoperative symptomatic status. CONCLUSION: In terms of integrated assessment of the RV-PA unit, preoperative TAPSE/PASP ratio and PVRI were important determinants of residual symptoms after ASD closure.
    2021年05月, The international journal of cardiovascular imaging, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yuki Yamauchi, Hidekazu Tanaka, Shun Yokota, Yasuhide Mochizuki, Yuko Yoshigai, Hiroaki Shiraki, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: Left ventricular (LV) longitudinal myocardial dysfunction is considered a marker of preclinical LV dysfunction in patients with type 2 diabetes mellitus (T2DM). High heart rate (HR) is associated with cardiovascular outcomes, but the effect of HR on LV longitudinal myocardial function in T2DM patients is uncertain. METHODS: We studied 192 T2DM patients with preserved LV ejection fraction (LVEF), and 81 age-, sex-, and LVEF-matched healthy volunteers. HR was measured as the average HR during echocardiography, and high HR was defined as resting HR ≥ 70 beats/minute. LV longitudinal myocardial function was assessed as global longitudinal strain (GLS). The predefined cutoff for subclinical LV dysfunction was set at GLS < 18%. RESULTS: GLS in T2DM patients with high HR was significantly lower than that in T2DM patients with low HR (16.3% ± 4.2% vs. 17.8% ± 2.8%; P = 0.03), whereas GLS in normal subjects with high and low HR was similar (20.3 ± 1.7% vs. 20.3 ± 2.0%; P = 0.99). Multivariable logistic regression analysis showed that high HR (odds ratio: 1.04; 95% confidence interval: 1.01-1.07; P = 0.01) was independently associated with GLS < 18% in T2DM patients as well as HbA1c, T2DM duration, LVEF, body mass index, and mitral inflow E and mitral e' annular velocity ratio. One sequential logistic model evaluating the associations between GLS < 18% and clinical variables in T2DM patients showed an improvement with the addition of LVEF and E/e' (P < 0.001) and a further improvement with the addition of high HR (P < 0.001). CONCLUSION: Compared with normal subjects, resting HR was associated with LV longitudinal myocardial function in asymptomatic T2DM patients with preserved LVEF. Our findings provide new insights on the management of T2DM patients.
    2021年04月, Cardiovascular diabetology, 20(1) (1), 87 - 87, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Fumitaka Soga, Kensuke Matsumoto, Ken-Ichi Hirata
    The aim of this study was to investigate the association of type 2 diabetes mellitus (T2DM) with the development of new-onset atrial fibrillation (AF) for non-ischemic dilated cardiomyopathy (DCM) patients. We also tested the hypothesis that sodium glucose cotransporter type 2 (SGLT2) inhibitors reduce the risk of development of new-onset AF for non-ischemic DCM patients. We retrospectively studied 210 patients with non-ischemic DCM and sinus rhythm, mean age of 59.0 ± 16.7 years and left ventricular ejection fraction of 31.0 ± 8.2% (all < 45%). T2DM was identified in 60 patients (28.6%), and the remaining 150 patients (71.4%) were classified as non-T2DM patients. New-onset AF occurred in 21 patients (10.0%) over a median follow-up of 6.1 years. Kaplan-Meier curve analysis showed that non-ischemic DCM patients without T2DM experienced fewer occurrences of the development of new-onset AF compared with those with T2DM (log-rank p = 0.0003). Furthermore, global longitudinal strain in patients who showed development of new-onset AF was significantly lower than that in those whose sinus rhythm was preserved (6.4 ± 1.4% vs. 7.7 ± 2.2%, p = 0.01). Of the 60 non-ischemic DCM patients with T2DM, those treated with SGLT2 inhibitors experienced fewer occurrences of the development of new-onset AF than did those not treated with SGLT2 inhibitors (log-rank p = 0.040). T2DM is associated with the development of new-onset AF in non-ischemic DCM patients, and treatment with SGLT2 inhibitors can significantly reduce the development of new-onset AF. Our findings may thus offer a new insight into the management of non-ischemic DCM patients with T2DM.
    2021年04月, The international journal of cardiovascular imaging, 37(4) (4), 1333 - 1341, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tomohiro Hayashi, Tomoya Yamashita, Tomoya Takahashi, Tokiko Tabata, Hikaru Watanabe, Yasuhiro Gotoh, Masakazu Shinohara, Kenjiro Kami, Hidekazu Tanaka, Kensuke Matsumoto, Tetsuya Hayashi, Takuji Yamada, Ken-Ichi Hirata
    Aims: Circulating amino acid (AA) abnormalities serve as predictors of adverse outcomes in patients with heart failure (HF). However, the role of the gut microbiota in AA disturbances remains unknown. Thus, we investigated gut microbial functions and their associations with AA metabolic alterations in patients with HF. Methods and Results: We performed whole-genome shotgun sequencing of fecal samples and mass spectrometry-based profiling of AAs in patients with compensated HF. Plasma levels of total essential AAs (EAAs) and histidine were significantly lower in patients with HF than in control subjects. HF patients also displayed increased and decreased abundance of gut microbial genes involved in the degradation and biosynthesis, respectively, of EAAs, including branched-chain AAs (BCAAs) and histidine. Importantly, a significant positive correlation was observed between the abundance of microbial genes involved in BCAA biosynthesis and plasma BCAA levels in patients with HF, but not in controls. Moreover, network analysis revealed that the depletion of Eubacterium and Prevotella, which harbor genes for BCAA and histidine biosynthesis, contributed to decreased abundance of microbial genes involved in the biosynthesis of those EAAs in patients with HF. Conclusions: The present study demonstrated the relationship between gut microbiota and AA metabolic disturbances in patients with HF.
    2021年, Frontiers in cardiovascular medicine, 8, 789325 - 789325, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hiroyuki Takahara, Takayoshi Toba, Daichi Fujimoto, Yu Izawa, Kensuke Matsumoto, Hidekazu Tanaka, Ken-ichi Hirata
    Elsevier Ltd, 2021年, Journal of Cardiology Cases, 英語
    研究論文（学術雑誌）

  • Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Ken-Ichi Hirata
    Japanese Society of Internal Medicine, 2021年, Internal Medicine, 60(15) (15), 2367 - 2374, 英語
    研究論文（学術雑誌）

  • Kentaro Yamashita, Hidekazu Tanaka, Keiko Hatazawa, Yusuke Tanaka, Keiko Sumimoto, Ayu Shono, Makiko Suzuki, Shun Yokota, Makiko Suto, Jun Mukai, Hiroki Takada, Kensuke Matsumoto, Hironobu Minami, Ken-ichi Hirata
    Springer Science and Business Media LLC, 2021年01月, The International Journal of Cardiovascular Imaging, 37(1) (1), 197 - 205
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yusuke Tanaka, Hidekazu Tanaka, Keiko Hatazawa, Kentaro Yamashita, Keiko Sumimoto, Ayu Shono, Makiko Suzuki, Shun Yokota, Makiko Suto, Jun Mukai, Hiroki Takada, Kensuke Matsumoto, Hironobu Minami, Ken-ichi Hirata
    Elsevier BV, 2021年01月, International Journal of Cardiology, 323, 126 - 132
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keisuke Miwa, Kensuke Matsumoto, Hiroshi Fujita, Eriko Hisamatsu, Hidekazu Tanaka, Koji Fukuzawa, Naoe Jimbo, Takeaki Shirai, Kenichi Hirata
    We report the case of a 31-year-old man with Uhl's anomaly. Echocardiography revealed severely enlarged nonfunctioning right ventricle and unusual findings of the premature opening of the pulmonary valve along with substantial forward flow during late-diastole, indicating that pulmonary circulation was largely dependent on compensatory right atrial contraction. Moreover, right-to-left shunt through the patent foramen ovale (PFO) achieved systemic circulation at the expense of severe hypoxia. During accelerated idioventricular rhythm (AIVR) accompanied by ventriculo-atrial (VA) conduction, hypoxemia deteriorated further because of an increased right-to-left shunt through the PFO. We report the case of an adult with Uhl's anomaly whose hemodynamics was largely dependent on the ventricularized right atrium and PFO. Although the unique hemodynamics contributed to his survival into adulthood, detrimental aspects manifested themselves during AIVR with VA conduction like a "double-edged sword." .
    2020年12月, Journal of cardiology cases, 22(6) (6), 305 - 308, 英語, 国内誌

  • Shun Yokota, Kensuke Matsumoto, Hidekazu Tanaka, Hidekazu Nakai, Kenji Okada, Ken-Ichi Hirata
    We present an extremely rare case of mitral Ebstein's anomaly that resulted in severe mitral regurgitation (MR). A 41-year-old woman with a history of tuberous sclerosis underwent surgery. Preoperatively, it was assumed that MR had occurred due to leaflet tethering related to left ventricular posterior wall motion asynergy due to a scarred rhabdomyoma. However, surgical inspection revealed a dysplastic posterior leaflet adhering to the ventricular wall, which was completely covered by the endocardium. Both congenital mitral Ebstein's anomaly and acquired wall motion abnormality due to a scarred rhabdomyoma may have contributed to the development of severe MR in this case.
    2020年11月, Internal medicine (Tokyo, Japan), 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keiko Sumimoto, Kensuke Matsumoto, Kenji Okada, Ken-Ichi Hirata
    2020年09月, European heart journal, 41(35) (35), 3378 - 3378, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makoto Yoshiji, Kensuke Matsumoto, Hiroshi Fujita, Keisuke Miwa, Hidekazu Tanaka, Masato Komatsu, Ken-Ichi Hirata
    A 53-year-old woman was admitted to another hospital because of a 2-month history of repeated chest pain and breathlessness. Laboratory examinations demonstrated the presence of hypereosinophilia (absolute count of 6,500/μL). An endomyocardial biopsy confirmed eosinophilic infiltration with myocardial destruction. On cardiac magnetic resonance imaging, late gadolinium enhancement was clearly observed along the visceral pericardium as well as on the endocardial layer. Based on the multimodal imaging and histopathological findings, the final diagnosis of "Löffler pancarditis" was made. After the introduction of steroid therapy, the left ventricular contractile function significantly recovered. Furthermore, the late gadolinium enhancement of the visceral pericardium had attenuated.
    2020年09月, Internal medicine (Tokyo, Japan), 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Jun Mukai, Hidekazu Tanaka, Hiroyuki Sano, Shun Yokota, Makiko Suto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Kensuke Matsumoto, Kazuhiko Nakayama, Noriaki Emoto, Ken-Ichi Hirata
    Functional tricuspid regurgitation (FTR) is associated with prognosis for various heart diseases, but its association with pulmonary hypertension (PH) remains unclear. We studied 111 PH patients. Mid-term follow-up echocardiography was performed 7.1 ± 4.1 months after PH-specific therapy. The severity of FTR was graded as none or trace, mild, moderate, or severe, while more than moderate TR was defined as significant. Moreover, mid-term improvement in FTR after therapy was defined as an improvement in severity of FTR by a grade of 1 or more. Long-term follow-up to determine the primary endpoint of death or hospitalization for heart failure lasted 39 ± 14 months. Mid-term improvement in FTR after PH-specific treatment was observed in 25 patients (23%), and the primary end points occurred in 27 patients (24%) during the long-term follow-up. The Kaplan-Meier curve indicated that the non-FTR group showed more favorable long-term outcomes than the FTR group (log-rank P = 0.008). It further indicated that patients with mid-term improvement in FTR also had more favorable long-term outcomes than those without such improvement (log-rank P = 0.03). When divided into four sub-groups based on combined assessment of baseline FTR and mid-term improvement in FTR, long-term outcomes for patients without mid-term improvement in their baseline FTR were worse than for the other sub-groups (log-rank P = 0.02). Multiple regression analysis showed that a relative change in tricuspid annular diameter at the mid-term follow-up after PH-specific therapy was the only independent determinant parameters for mid-term improvement in FTR. FTR appears to be a valuable factor for predicting long-term outcomes for PH patients, and combined assessment of baseline FTR and mid-term improvement in FTR after PH-specific therapy may have clinical implications for better management of such patients.
    2020年07月, The international journal of cardiovascular imaging, 36(7) (7), 1261 - 1269, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suto, Kensuke Matsumoto, Akira Onishi, Nao Shibata, Shun Yokota, Jun Mukai, Eriko Hisamatsu, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Hidekazu Tanaka, Ken-Ichi Hirata
    BACKGROUND: Long-term sequelae such as right ventricular dysfunction and reduced hemodynamic reserve are the main determinants of cardiovascular outcomes after repair of tetralogy of Fallot (TOF). Echocardiographic parameters at rest offer only partial information on impaired hemodynamics in these patients, and data during stress testing are lacking. The leg-positive pressure (LPP) maneuver has recently been reported to be able to apply acute preload stress. The aim of this study was to test the hypothesis that preload reserve is impaired and ventricular interaction is exacerbated in patients with TOF. METHODS: In this prospective cross-sectional study, we recruited 44 consecutive patients with TOF and 30 normal control subjects. Echocardiography was performed both at rest and during LPP stress, and preload reserve was defined as the change between baseline stroke volume (SV) and that obtained during LPP stress. The eccentricity index was calculated as the ratio of the left ventricular anteroposterior to septal-lateral dimensions to quantify ventricular interaction. RESULTS: LPP stress significantly increased SV from 73 ± 14 to 83 ± 16 mL (P < .01) in control subjects, while the increase in SV was significantly blunted (from 75 ± 19 to 79 ± 18 mL; P < .01 for interaction) in patients with TOF. The eccentricity index significantly changed during LPP stress in patients with TOF only from 1.07 ± 0.13 to 1.13 ± 0.14 (P < .01 for interaction). Patients with TOF were subdivided into two subgroups on the basis of the median value of increased response in SV (22 with sufficient and 22 with insufficient preload reserve). Multivariate analysis identified significant pulmonary regurgitation as the only independent determinant factor for insufficient preload reserve (odds ratio, 4.57; 95% CI, 1.048-19.90; P = .04). CONCLUSIONS: In patients after repair of TOF, ventricular interaction was exacerbated and preload reserve was impaired, especially in patients with significant pulmonary regurgitation. LPP stress testing may direct tailored treatment approaches, risk stratification, and clinical decision-making, such as more aggressive pharmacologic therapy, meticulous outpatient follow-up, or earlier reintervention.
    2020年07月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 33(7) (7), 858 - 867, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Kensuke Matsumoto, Ken-Ichi Hirata
    BACKGROUND: Left ventricular (LV) longitudinal dysfunction has been identified in type 2 diabetes mellitus (T2DM) patients with preserved LV ejection fraction (LVEF). However, the impact of T2DM on LV longitudinal function or the association of LV longitudinal function with outcome for dilated cardiomyopathy (DCM) remains unclear. METHODS: We retrospectively studied 206 patients with non-ischemic DCM, mean age of 59 ± 17 years and LVEF of 31 ± 8% (all < 45%). All patients underwent a standard echocardiographic examination, and LV longitudinal function was assessed in terms of global longitudinal strain (GLS). Long-term outcomes were assessed, with a median follow-up period of 6.2 years, as primary endpoints of death from or hospitalization for deteriorating heart failure. RESULTS: GLS of DCM patients with T2DM (n = 55) was significantly lower than that in DCM patients without T2DM (n = 151) in spite of similar conventional LV function (7.0 ± 2.0% vs. 7.8 ± 2.2%, p = 0.03). Kaplan-Meier curves indicated that long-term outcomes for DCM patients without T2DM were better than for those with T2DM (log-rank p = 0.001). Subdividing the two groups into four with by using the median value of GLS (7.9%) showed long-term outcome was worst for DCM patients with T2DM and low GLS. Cox proportional hazards analyses demonstrated an independent association of T2DM, GLS and left atrial volume index with long-term outcome. Moreover, multiple regression analysis for the association of GLS showed that T2DM was the independent determinant parameter for GLS as well as for LVEF and left atrial volume index. CONCLUSION: Management of DCM patients with T2DM may be improved by using GLS guidance.
    2020年06月, Cardiovascular diabetology, 19(1) (1), 84 - 84, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suto, Kensuke Matsumoto, Hidekazu Tanaka, Ken-Ichi Hirata
    Oxford University Press, 2020年06月, European Heart Journal - Case Reports, 4(3) (3), 英語
    研究論文（学術雑誌）

  • Kumiko Dokuni, Kensuke Matsumoto, Kazuhiro Tatsumi, Makiko Suto, Hidekazu Tanaka, Koji Fukuzawa, Ken-Ichi Hirata
    This study aimed to test the hypothesis that left ventricular dyssynchrony may negatively affect left atrial (LA) dyssynchrony and reservoir function, and cardiac resynchronization therapy (CRT) may improve LA function. It also assessed, whether residual LA dyssynchrony affects the prognosis in patients with heart failure with reduced ejection fraction (HFrEF). Ninety subjects were included: 40 HFrEF patients with a wide-QRS complex (≧130 ms), 28 HFrEF patients with a narrow-QRS, and 22 normal controls. LA global longitudinal strain (LA-GLS) and LA dyssynchrony were quantified by speckle-tracking strain analysis. LA dyssynchrony was defined as the maximal difference of time-to-peak strain (LA time-diff). All patients with a wide-QRS underwent CRT, and event-free survival was tracked for 24 months. At baseline, LA dyssynchrony was significantly more pronounced in patients with a wide-QRS HFrEF (342 ± 126 ms) than that in patients with a narrow-QRS (236 ± 127 ms, P < 0.001) and controls (186 ± 78 ms, P < 0.001). Six months after CRT, LA-GLS significantly improved from 11.9 ± 4.7 to 19.6 ± 10.1% (P < 0.05) and LA time-diff was reduced from 338 ± 123 to 245 ± 141 ms (P < 0.05) in responders only. Patients with an LA time-diff < 202 ms and those with an LA-GLS ≧14.6% six months after CRT showed significantly better outcomes than the others (P < 0.05, respectively). Among the responders, those with an LA time-diff < 202 ms after CRT showed a better prognosis than others (P < 0.05). CRT improved LA dyssynchrony and reservoir function through the improved left ventricular coordination. Reduced LA dyssynchrony and improved LA reservoir function after CRT lead to better outcomes.
    2020年03月, The international journal of cardiovascular imaging, 36(7) (7), 1203 - 1212, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keiko Sumimoto, Hidekazu Tanaka, Jun Mukai, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Shun Yokota, Makiko Suto, Hiroki Takada, Kensuke Matsumoto, Yu Taniguchi, Noriaki Emoto, Ken-Ichi Hirata
    Remodeling in the right-sided heart plays an important role in the management of pulmonary hypertension (PH) patients. However, the effect of balloon pulmonary angioplasty (BPA) on right ventricular (RV) and right atrial (RA) morphology of patients with chronic thromboembolic pulmonary hypertension (CTEPH) remains uncertain. This study involved 45 CTEPH patients who underwent BPA with mean pulmonary artery pressure (mPAP) of 37.0 mmHg (all ≥ 25 mmHg). All patients underwent echocardiography and right-heart catheterization at baseline and 3 months after BPA. RV and RA remodeling was assessed as RV and the RA area, and RV systolic function was calculated by averaging peak speckle-tracking longitudinal strain of the RV free-wall (RV free-wall strain). Significant reverse remodeling in the right-sided heart was observed after BPA, resulting in improvement of mPAP and pulmonary vascular resistance (RV area: from 15.0 ± 5.3 to 9.6 ± 3.0 cm2, p < 0.0001; RA area: from 17.3 ± 6.6 to 13.4 ± 3.8 cm2, p = 0.0002; RV free-wall strain: from 15.9 ± 5.6 to 21.2 ± 4.9%, p < 0.0001). Furthermore, multiple regression analysis showed that the baseline RV area was an independent predictor of post-BPA normalization of RV systolic function defined as RV free-wall strain ≥ 20% (odds ratio = 1.16, p = 0.0305). Interestingly, significant RV reverse remodeling was also observed after additional BPA even in 18 CTEPH patients with residual pulmonary arterial stenosis, whose mPAP was normalized after BPA (RV area: from 11.5 ± 3.8 to 9.2 ± 3.8 cm2, p = 0.0045; RV free-wall strain: from 17.2 ± 4.8 to 22.8 ± 7.4%, p = 0.0216). Significant reverse remodeling in the right-sided heart, as well as hemodynamic improvement, was observed in CTEPH patients after BPA.
    2020年02月, The international journal of cardiovascular imaging, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Yutaka Hatani, Hidekazu Tanaka, Yasuhide Mochizuki, Makiko Suto, Shun Yokota, Jun Mukai, Hiroki Takada, Fumitaka Soga, Keiko Hatazawa, Hiroki Matsuzoe, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: Left ventricular (LV) longitudinal myocardial systolic dysfunction (LVSD) has been identified in type 2 diabetes mellitus (T2DM) patients, and it should be considered the first marker of a preclinical form of DM-related cardiac dysfunction. Overweight has been postulated to contribute to the development of LVSD in T2DM patients, but the impact of amount of body fat mass on LVSD in T2DM patients remains uncertain. METHODS: We studied 71 asymptomatic T2DM patients with preserved LV ejection fraction (LVEF) (all ≥55%) without coronary artery disease. LVSD for T2DM patients with preserved LVEF was identified as global longitudinal strain (GLS) <18%. Body fat mass was measured with a commercially available body composition analyzer (In Body S-10, Biospace, Tokyo, Japan), and corrected by body surface area (BFI: body fat index). RESULTS: Univariate logistic regression analysis revealed that body weight, body mass index (BMI), and BFI were all associated with LVSD, whereas multivariate logistic regression analysis showed BFI was the only variable independently associated with LVSD (OR 1.147; 95% CI 1.001-1.314; p = 0.027). For sequential logistic regression models to predict LVSD, clinical variables including age, DM duration, and HbA1c tended to be improved by addition of BMI, but without statistical significance (p = 0.09), while it was significantly improved by addition of BFI (p = 0.047). CONCLUSIONS: Using BFI for the control of body compression by means of a bioelectrical impedance assay is simple and easy-to-use, and this may have clinical implications for better management of T2DM patients with preserved LVEF to prevent future development of DM-related cardiac dysfunction.
    2020年02月, Journal of cardiology, 75(2) (2), 189 - 195, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suzuki, Kensuke Matsumoto, Makiko Suto, Yayoi Taniguti, Hidekazu Tanaka, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    A 92-year-old man was referred to our hospital with decompensated heart failure. He was treated with diuretics and inotropic agents, but the clinical response was unsatisfactory. Echocardiography incidentally revealed an atrial septal defect (ASD) with a significant left-to-right shunt and pulmonary-to-systemic-blood-flow ratio of 2.36. Because the ASD was considered to be the primary cause of his treatment-resistant heart failure, the patient underwent transcatheter ASD closure. Shortly after shunt closure, his hemodynamics significantly improved, and he was discharged nine days later. This is an extremely rare case of a nonagenarian who showed an excellent clinical course after transcatheter ASD closure.
    2020年02月, Internal medicine (Tokyo, Japan), 59(8) (8), 1059 - 1063, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hidekazu Tanaka, Fumitaka Soga, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Ken-Ichi Hirata
    BACKGROUND: The effect of sodium glucose cotransporter type 2 (SGLT2) inhibitor on left ventricular (LV) longitudinal myocardial function in type 2 diabetes mellitus (T2DM) patients with heart failure (HF) has remained unclear. METHODS: We analyzed data from our previous prospective multicenter study, in which we investigated the effect of the SGLT2 inhibitor dapagliflozin on LV diastolic functional parameters of T2DM patients with stable HF at five institutions in Japan. Echocardiography was performed at baseline and 6 months after administration of dapagliflozin. LV diastolic function was defined as the ratio of mitral inflow E to mitral e' annular velocities (E/e'). LV longitudinal myocardial function was assessed as global longitudinal strain (GLS), which in turn was determined as the averaged peak longitudinal strain from standard LV apical views. RESULTS: E/e' significantly decreased from 9.3 to 8.5 cm/s 6 months after administration of dapagliflozin (p = 0.020) as previously described, while GLS showed significant improvement from 15.5 ± 3.5% to 16.9 ± 4.1% (p < 0.01) 6 months after administration of dapagliflozin. Furthermore, improvement of GLS in HF with preserved ejection fraction patients was more significant from 17.0 ± 1.9% to 18.7 ± 2.0% (p < 0.001), compared to that in HF with mid-range ejection fraction and HF with reduced ejection fraction patients from 14.4 ± 2.4% to 15.5 ± 1.8% (p = 0.06) and from 8.1 ± 1.5% to 7.8 ± 2.1% (p = 0.44), respectively. It was noteworthy that multiple regression analysis showed that the change in GLS after administration of dapagliflozin was the only independent determinant parameters for the change in E/e' after administration of dapagliflozin. CONCLUSION: Dapagliflozin was found to be associated with improvement of LV longitudinal myocardial function, which led to further improvement of LV diastolic function of T2DM patients with stable HF. GLS-guided management may thus lead to improved management of T2DM patients with stable HF.
    2020年01月, Cardiovascular diabetology, 19(1) (1), 6 - 6, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroshi Fujita, Kensuke Matsumoto, Keisuke Miwa, Makiko Suzuki, Makiko Suto, Jun Sakai, Hidekazu Tanaka, Ken-Ichi Hirata
    International Scientific Information, Inc., 2020年, American Journal of Case Reports, 21, 1 - 6, 英語
    研究論文（学術雑誌）

  • 『精神心理学的・社会的課題とメンタルケア』ACHD多職種連携診療体制の中で患者の心のケアとどう向き合うか? ACHD診療における緩和ケア『語り』の立場から
    松本 賢亮, 鈴木 麻希子, 須藤 麻貴子, 坂下 明大, 木澤 義之, 平田 健一
    日本成人先天性心疾患学会, 2020年01月, 日本成人先天性心疾患学会雑誌, 9(1) (1), 188 - 188, 日本語

  • Yasue Sato, Kensuke Matsumoto, Jun Sakai, Toshihiro Nakamura, Hidekazu Tanaka, Kenichi Hirata
    This case report concerns an 81-year-old woman with previously well-controlled hypertrophic obstructive cardiomyopathy (HOCM). She was referred to our hospital because of the acute onset of takotsubo syndrome. Echocardiography revealed basal hyperkinesis due to takotsubo syndrome superimposed on septal hypertrophy, which resulted in the reappearance of prominent left ventricular outflow tract obstruction (LVOTO). Although she developed cardiogenic shock triggered by atrial fibrillation, LVOTO was successfully mitigated by aggressive fluid resuscitation, rhythm control, and the administration of β-blocker. We herein report a rare case with catastrophic hemodynamics due to the incidental combination of HOCM and takotsubo syndrome.
    2019年12月, Internal medicine (Tokyo, Japan), 英語, 国内誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Shun Yokota, Hidekazu Tanaka, Yasuhide Mochizuki, Fumitaka Soga, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Keiko Sumimoto, Jun Mukai, Makiko Suto, Hiroki Takada, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major cause of heart failure (HF) with preserved ejection fraction (HFpEF), usually presenting as left ventricular (LV) diastolic dysfunction. Thus, LV diastolic function should be considered a crucial marker of a preclinical form of DM-related cardiac dysfunction. However, the impact of glycemic variability (GV) on LV diastolic function in such patients remains unclear. METHODS: We studied 100 asymptomatic T2DM patients with preserved LV ejection fraction (LVEF) without coronary artery disease (age: 60 ± 14 years, female: 45%). GV was evaluated as standard deviation of blood glucose level using continuous glucose monitoring system for at least 72 consecutive hours. LV diastolic function was defined as mitral inflow E and mitral e' annular velocities (E/e'), and > 14 was determined as abnormal. RESULTS: E/e' in patients with high GV (≥ 35.9 mg/dL) was significantly higher than that in patients with low GV (11.3 ± 3.9 vs. 9.8 ± 2.8, p = 0.03) despite similar age, gender-distribution, and hemoglobin A1c (HbA1c). Multivariate logistic regression analysis showed that GV ≥ 35.9 mg/dL (odds ratio: 3.67; 95% confidence interval: 1.02-13.22; p < 0.05) was an independently associated factor, as was age, of E/e' > 14. In sequential logistic models for the associations of LV diastolic dysfunction, one model based on clinical variables including age, gender and hypertension was not improved by addition of HbA1c (p = 0.67) but was improved by addition of high GV (p = 0.04). CONCLUSION: Since HFpEF is a syndrome caused by diverse agents, reducing GV may represent a potential new therapeutic strategy for the prevention of the development of HFpEF in T2DM patients.
    2019年12月, Cardiovascular diabetology, 18(1) (1), 166 - 166, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keiko Sumimoto, Kensuke Matsumoto, Yu Izawa, Shunpei Mori, Hidekazu Tanaka, Ken-Ichi Hirata
    We report the case of a 63-year-old man who was admitted to our hospital due to progressive dyspnea and leg edema. Echocardiography and cardiac computed tomography revealed localized severe pericardial calcification surrounding the basal segments of both ventricles, which caused pericardial constriction. Right heart catheter examination confirmed typical hemodynamic findings of constrictive pericarditis and subsequently led to the definite diagnosis of constrictive pericarditis. We experienced a rare case of localized constrictive pericarditis caused by the thickened and calcified pericardial ring. Non-invasive and invasive multimodality evaluations should be encouraged for accurate diagnosis and better management of these cases.
    2019年12月, Echocardiography (Mount Kisco, N.Y.), 36(12) (12), 2265 - 2267, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Jun Mukai, Makiko Suto, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Kensuke Matsumoto, Koji Fukuzawa, Ken-Ichi Hirata
    BACKGROUND: The underlying mechanism of mitral regurgitation (MR) in atrial fibrillation (AF) is an isolated annulus dilation caused by left atrial (LA) remodeling. However, the association of mitral valve (MV) geometry with MR in AF patients remains unclear.Methods and Results:We studied 96 AF patients with preserved left ventricular ejection fraction (LVEF). MV geometry was evaluated with 3-dimensional transesophageal echocardiography (3D-TEE). Mitral annulus area of the MR group (n=11, ≥ moderate) was significantly larger (10.6±1.8 vs. 8.2±1.5 cm2, P<0.0001), and relative posterior mitral leaflet (PML) area (PML area / mitral annulus area) was significantly smaller (0.51±0.06 vs. 0.57±0.01, P=0.002) than in the non-MR group (n=85, 2019年10月, Circulation journal : official journal of the Japanese Circulation Society, 83(11) (11), 2312 - 2319, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Junichi Ooka, Kensuke Matsumoto, Morihiko Kondo, Toshiyuki Otomo
    Background : Calcification of the left atrium (LA) is a rare condition and can be the result of long-standing rheumatic mitral stenosis or an unusual complication after mitral valve replacement. Cases of massive LA calcification have sometimes been referred to as those with 'coconut LA' or 'porcelain LA'. Case summary : A 75-year-old woman was referred to our hospital because of chest discomfort and exertional dyspnoea. Doppler echocardiography revealed the presence of elevated filling pressure with significant LA dysfunction. A cardiac catheter examination revealed a quite impressive pulmonary capillary wedge pressure waveform with a steep up-slope and prominent v wave of 43 mmHg (mean: 15 mmHg). Multidetector row computed tomography revealed that LA was sandwiched by dense calcifications along the roof and bottom of the LA, and the posterior wall was compressed by a vertebral body. Integration of these functional and anatomical findings ultimately led to the diagnosis of 'stiff LA syndrome'. Discussion : She had a history of tuberculosis but no history of rheumatic fever or cardiac surgery. Thus, it appeared that the tuberculous pericarditis might have led to the calcified LA by long lasting inflammation. In this case, the LA was encased by a dense calcification and compressed by vertebral body from the posterior direction. Therefore, we speculated that the LA pressure could easily elevate even with a slight haemodynamic load in this special case, and thus eventually resulting in decompensated heart failure.
    2019年09月, European heart journal. Case reports, 3(3) (3), ytz154, 英語, 国際誌
    [査読有り]

  • Toshihiro Nakamura, Koji Fukuzawa, Jun Kurose, Hideya Suehiro, Kensuke Matsumoto, Ken-Ichi Hirata
    2019年08月, HeartRhythm case reports, 5(8) (8), 419 - 423, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Makiko Suto, Hiroki Takada, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Sano, Junichi Ooka, Hiroyuki Shimoura, Kensuke Matsumoto, Koji Fukuzawa, Ken-Ichi Hirata
    OBJECTIVES: Our aim was to test the hypothesis that comprehensive simplified left atrial (LA) assessment derived from routine echocardiography may be more useful than assessment of LA volume alone for predicting atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS: We studied 156 patients with paroxysmal AF (PAF) who had undergone PVI. Echocardiography was performed within two days before PVI. Maximum (Max-LAVi) and minimum LA volume index (Min-LAVi) were calculated with the biplane modified Simpson's method, and then normalized to the body surface area. On the basis of previous findings, the predefined cutoff value of Max-LAVi for AF recurrence was set at Max-LAVi ≥ 34 mL/m2 . ΔLA volume index (ΔLAVi) was also calculated as Max-LAVi minus Min-LAVi. The follow-up period after PVI was 24 months. RESULTS: AF recurrence was observed in 35 patients. Multivariate logistic regression analysis showed that ΔLAVi (odds ratio [OR]: 1.131; 95% confidence interval [CI]: 1.057-1.221; P < 0.001) was an independent predictor of AF recurrence. Sequential logistic regression models for predicting AF recurrence revealed that a model based on clinical variables including age, gender and AF duration (χ2  = 1.65) was improved by the addition of Max-LAVi ≥ 34 mL/m2 (χ2  = 13.8; P < 0.001), and further improved by the addition of ΔLAVi (χ2  = 18.2; P = 0.036). Of note is that only 1.02 ± 0.10 minutes per patient was needed to obtain a comprehensive LA assessment that included Max-LAVi, Min-LAVi, and ΔLAVi. CONCLUSION: This easy-to-use comprehensive simplified LA approach from routine echocardiography may well have clinical implications for better management of PAF patients.
    2019年05月, Echocardiography (Mount Kisco, N.Y.), 36(5) (5), 862 - 869, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hidekazu Tanaka, Kensuke Matsumoto, Ken-Ichi Hirata
    It is well known that patent ductus arteriosus (PDA) in adults, especially in the elderly, differs from that in pediatric patients. A 68-year-old woman with a PDA with focal calcification at the aortic orifice of the ampulla with a minimum diameter of 4.0 mm and length of 14.8 mm, was treated with a 10/8-mm Amplatzer duct occluder (ADO) (St. Jude Medical Corp, St. Paul, MN, USA). After device implantation, systolic blood pressure (BP) increased to approximately 220 mmHg from 130 mmHg. She experienced transient dyspnea from hypertensive heart failure, which improved through continuous infusion of anti-hypertensive agents. She suddenly felt pressure on her chest 12 h post-procedure and collapsed. Surgical thoracotomy revealed an ascending aortic dissection into the pericardial space. In retrospective review, the ADO may have been slightly deformed by fluoroscopy. The complication may have been triggered by the resilience caused by device deformation, damage to the aortic wall due to the aortic side of the device, uneven elasticity of the arterial wall, and uncontrolled excessively high blood pressure. .
    2019年03月, Journal of cardiology cases, 19(3) (3), 85 - 88, 英語, 国内誌
    [査読有り]

  • Hiroyuki Yamamoto, Hiromasa Otake, Teiji Akagi, Kensuke Matsumoto, Soichiro Henmi, Takeshi Inoue, Hiroshi Tanaka, Ken-Ichi Hirata
    2019年01月, JACC. Cardiovascular interventions, 12(1) (1), e5-e7 - e7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suto, Kensuke Matsumoto, Sachiko Kido, Shumpei Mori, Kazuhiko Nakayama, Hidekazu Tanaka, Takeshi Inoue, Noriaki Emoto, Yutaka Okita, Ken-Ichi Hirata
    This case report concerns a 22-year-old woman with large patent ductus arteriosus and atrial septal defect. She was referred to our hospital because of exertional dyspnea and was revealed to have advanced pulmonary arterial hypertension (PAH) with a mean pulmonary arterial pressure (PAP) of 79 mmHg. Although both shunts had bidirectional flow, based on the results of acute pulmonary vasoreactive testing, one-stage surgical closure was performed followed by up-front combination therapy for post-operative pulmonary hypertensive crisis and residual PAH. At 14 months after the surgery, her symptoms were markedly improved, and her mean PAP had dramatically decreased to 13 mmHg.
    2019年, Internal medicine (Tokyo, Japan), 58(9) (9), 1301 - 1305, 英語, 国内誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Nao Shibata, Kensuke Matsumoto, Satoru Kitamura, Akihiro Sakashita, Yoshiyuki Kizawa, Ken-Ichi Hirata
    A 67-year-old woman was admitted to our hospital due to an acute onset of consciousness disturbance, aphasia and left hemiplegia. Computed tomography revealed multiple systemic infarctions, including brain, kidney and spleen. Transesophageal echocardiography revealed vegetations attached to the mitral valve leaflets, which was suspected to be the embolic source. Repeated blood cultures were negative, and advanced lung cancer was incidentally revealed by computed tomography. She was then diagnosed with nonbacterial thrombotic endocarditis (NBTE) based on the overall clinical picture. Subsequently, extensive systemic embolization repeatedly occurred, and she eventually died 25 days after admission. The autopsy proved NBTE and advanced-stage lung adenocarcinoma.
    2018年12月, Internal medicine (Tokyo, Japan), 57(24) (24), 3559 - 3563, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Shibata Nao, Matsumoto Kensuke, Kitamura Satoru, Sakashita Akihiro, Kizawa Yoshiyuki, Hirata Kenichi
    <p>A 67-year-old woman was admitted to our hospital due to an acute onset of consciousness disturbance, aphasia and left hemiplegia. Computed tomography revealed multiple systemic infarctions, including brain, kidney and spleen. Transesophageal echocardiography revealed vegetations attached to the mitral valve leaflets, which was suspected to be the embolic source. Repeated blo
    一般社団法人 日本内科学会, 2018年12月, Internal Medicine, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Kazuhiko Nakayama, Kensuke Matsumoto, Hirotsugu Yamada, Noriaki Emoto, Ken-Ichi Hirata
    OBJECTIVES: Pulmonary hypertension (PH) is characterized by marked and sustained elevation of pulmonary vascular resistance and pulmonary artery pressure, and subsequent right-sided heart failure. Right ventricular (RV) function and exercise capacity have been recognized as important prognostic factors for PH. Our aim was to investigate RV contractile reserve and exercise capacity during a leg-positive pressure (LPP) maneuver. METHODS: The study population comprised 43 PH patients and 17 normal controls. All patients underwent echocardiography at rest and during LPP stress. Exercise capacity was assessed by 6-minute walk distance for PH patients. RV relative wall thickness was calculated from dividing by RV free wall thickness by basal RV linear dimensions at end-diastole. RV function was calculated by averaging peak speckle-tracking longitudinal strain from the RV free wall. RV contractile reserve was assessed as the difference in RV free wall strain at rest and during LPP stress. Changes in left ventricular stroke volume (ΔSV) during LPP stress were also calculated. RESULTS: ΔSV and RV contractile reserve of PH patients were significantly lower than of controls (3.6 ± 6.0 mL vs 8.5 ± 2.3 mL, and 8.2 ± 11.9% vs 14.5 ± 6.6%; both P < 0.01). RV contractile reserve of PH patients with ΔSV <3.3 mL was significantly lower than of PH patients with ΔSV >3.3 mL (3.9 ± 13.2% vs 12.3 ± 8.9%; P = 0.02). ΔSV had also significant correlation with 6-minute walk distance (r = 0.42, P = 0.006). Multivariate regression analysis showed that RV relative wall thickness was an independent determinant parameter of ΔSV during LPP stress for PH patients (β = 3.2, P = 0.003). CONCLUSIONS: Preload stress echocardiography in response to LPP maneuver, a noninvasive and easy-to-use procedure for routine clinical use, proved to be useful for the assessment of RV contractile reserve and exercise capacity of PH patients.
    2018年12月, Echocardiography (Mount Kisco, N.Y.), 35(12) (12), 1997 - 2004, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Ken-Ichi Hirata
    BACKGROUND: The objective of this study was to investigate the impact of sodium glucose cotransporter type 2 (SGLT2) inhibitors on left ventricular (LV) diastolic function of type 2 diabetes mellitus (T2DM) patients with heart failure (HF). METHODS: This trial was a prospective multicenter study of 58 T2DM patients with stable HF at five institutions in Japan. Patients who had been taking at least one antidiabetic drugs other than SGLT2 inhibitors started the administration of 5 mg/day of dapagliflozin. The physical examinations, blood tests, and echocardiography were performed at baseline and 6 months after administration of dapagliflozin. The primary endpoint was defined as a change in mitral inflow E and mitral e' annular velocities (E/e') between baseline and 6 months after the administration of dapagliflozin. The secondary end points consisted of a change in brain natriuretic peptide (BNP), LV mass index (LVMI) and left atrial volume index (LAVI). RESULTS: E/e' significantly decreased from 9.3 to 8.5 cm/s (p = 0.020) 6 months after administration of dapagliflozin. LAVI and LVMI significantly decreased from 31 to 26 mL/m2 (p = 0.001), and from 75.0 to 67.0 g/m2 (p < 0.001), respectively, 6 months after administration of dapagliflozin. No significant change was observed in BNP (from 27.9 to 28.9 pg/mL; p = 0.132) 6 months after administration of dapagliflozin, except for a significant decrease from 168.8 to 114.3 pg/mL (p = 0.012) in patients with BNP ≥ 100 pg/mL. CONCLUSION: This prospective multicenter trial showed the beneficial effect of SGLT2 inhibitors on LV diastolic functional parameters for T2DM patients with HF. Our findings may thus offer a new insight into the management of T2DM patients. Trial registration UMIN000019789, Registered 28 September 2014, Date of registration: 11/14/2015, Date of enrolment of the first participant to the trial: 6/15/2016, Date of enrolment of the last participant to the trial: 12/9/2017.
    2018年10月, Cardiovascular diabetology, 17(1) (1), 132 - 132, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Keiko Hatazawa, Hidekazu Tanaka, Akiko Nonaka, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Kensuke Matsumoto, Ken-Ichi Hirata
    BACKGROUND: Our aim was to investigate the baseline clinical and echocardiographic parameters for predicting left ventricular (LV) dysfunction after anthracycline chemotherapy and heart failure (HF) hospitalization in a single cancer disease. Methods and Results: We studied 73 patients with malignant lymphoma and preserved LV ejection fraction (LVEF). Echocardiography was performed before and after anthracycline chemotherapy. Global longitudinal strain (GLS) was determined from 3 standard apical views. LV dysfunction after anthracycline chemotherapy was defined according to the current definition of cancer therapeutics-related cardiac dysfunction. Long-term (50-month) unfavorable outcome was prespecified as hospitalization for HF. A total of 10 patients had LV dysfunction after anthracycline chemotherapy. Multivariate logistic regression analysis showed that baseline GLS was the only independent predictor of this dysfunction. Receiver-operating characteristic curve analysis identified the optimal GLS cutoff for predicting LV dysfunction after anthracycline chemotherapy as ≤19% (P=0.008). Furthermore, the Kaplan-Meier curve indicated that fewer patients with GLS >19% were hospitalized for HF than among those with GLS ≤19% (log-rank P=0.02). For sequential logistic models, a model based on baseline clinical variables (χ2=2.9) was improved by the addition of baseline LVEF (χ2=9.0; P=0.01), and further improved by the addition of baseline GLS (χ2=13.1, P=0.04). CONCLUSIONS: Watchful observation or early therapeutic intervention with established cardioprotective medications may be necessary for patients with malignant lymphoma and preserved LVEF but with abnormal GLS.
    2018年09月, Circulation journal : official journal of the Japanese Circulation Society, 82(10) (10), 2566 - 2574, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 肺高血圧症における三尖弁閉鎖不全症と長期予後との関係
    向井 淳, 田中 秀和, 佐野 浩之, 高田 裕基, 曽我 文隆, 羽溪 優, 畑澤 圭子, 松添 弘樹, 松本 賢亮, 平田 健一
    (一社)日本心臓病学会, 2018年09月, 日本心臓病学会学術集会抄録, 66回, EP - 220, 日本語

  • Hiroki Matsuzoe, Hidekazu Tanaka, Keiko Hatazawa, Yutaka Hatani, Kensuke Matsumoto, Toshiro Shinke, Ken-Ichi Hirata
    2018年09月, Journal of echocardiography, 16(3) (3), 150 - 151, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka Okita, Ken-Ichi Hirata
    An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.
    2018年08月, The Canadian journal of cardiology, 34(8) (8), 1088.e11-1088.e13, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kensuke Matsumoto, Akira Onishi, Hirotsugu Yamada, Kenya Kusunose, Makiko Suto, Yutaka Hatani, Hiroki Matsuzoe, Kazuhiro Tatsumi, Hidekazu Tanaka, Ken-Ichi Hirata
    BACKGROUND: The leg-positive pressure maneuver can safely and noninvasively apply preload stress without increase in total body fluid volume. The purpose of this study was to determine whether preload stress could be useful for risk stratification of patients with heart failure with reduced ejection fraction. METHODS AND RESULTS: For this study, 120 consecutive patients with heart failure with reduced ejection fraction were prospectively recruited. The stroke work index was estimated as product of stroke volume index and mean blood pressure, and the E/e' ratio was calculated to estimate ventricular filling pressure. The echocardiographic parameters were obtained both at rest and during leg-positive pressure stress. During the median follow-up period of 20 months, 30 patients developed adverse cardiovascular events. During preload stress, stroke work index increased significantly (from 3280±1371 to 3857±1581 mm Hg·mL/m2; P<0.001) along with minimal changes in ventricular filling pressure (E/e', from 16±10 to 17±9; P<0.05) in patients without cardiovascular events. However, patients with cardiovascular events showed impairment of Frank-Starling mechanism (stroke work index, from 2863±969 to 2903±1084 mm Hg·mL/m2; P=0.70) and a serious increase in E/e' ratio (from 19±11 to 25±14; P<0.001). Both the patients without contractile reserve and those without diastolic reserve exhibited worse event-free survival than the others (P<0.001). In a Cox proportional-hazards analysis, the changes in stroke work index (hazard ratio: 0.44 per 500 mm Hg·mL/m2 increase; P=0.001) and in E/e' (hazard ratio: 2.58 per 5-U increase; P<0.001) were predictors of cardiovascular events. CONCLUSION: Contractile reserve and diastolic reserve during leg-positive pressure stress are important determinants of cardiovascular outcomes for patients with heart failure with reduced ejection fraction.
    2018年05月, Circulation. Cardiovascular imaging, 11(5) (5), e007160, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 肺高血圧症における三尖弁閉鎖不全症と長期予後との関係
    向井 淳, 田中 秀和, 佐野 浩之, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 松本 賢亮, 平田 健一
    (公社)日本超音波医学会, 2018年04月, 超音波医学, 45(Suppl.) (Suppl.), S556 - S556, 日本語

  • 2型糖尿病における体脂肪量と左室心筋長軸方向収縮機能障害の関連性(Association of Body Fat Mass with Left Ventricular Myocardial Systolic Longitudinal Dysfunction in Type 2 Diabetes Mellitus)
    羽渓 優, 田中 秀和, 望月 泰秀, 須藤 麻貴子, 横田 駿, 柴田 奈緒, 向井 淳, 高田 裕基, 曽我 文隆, 畑澤 圭子, 堂國 久美子, 松添 弘樹, 久松 恵理子, 松本 賢亮, 平田 健一
    (一社)日本循環器学会, 2018年03月, 日本循環器学会学術集会抄録集, 82回, OJ10 - 3, 英語

  • 心房細動患者における肺静脈隔離術後の心房細動再発を予測する左心房の総合的評価(Comprehensive Assessment of Left Atrium for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients with Atrial Fibrillation)
    曽我 文隆, 田中 秀和, 望月 泰秀, 横田 駿, 柴田 奈緒, 向井 淳, 須藤 麻貴子, 高田 裕基, 堂國 久美子, 羽渓 優, 松添 弘樹, 畑澤 圭子, 久松 恵理子, 松本 賢亮, 平田 健一
    (一社)日本循環器学会, 2018年03月, 日本循環器学会学術集会抄録集, 82回, PJ040 - 2, 英語

  • 心房細動および著しい僧帽弁逆流を有する患者の短縮した僧帽弁後尖(Shortened Posterior Mitral Leaflet in Patients with Atrial Fibrillation and Significant Mitral Regurgitation)
    高田 裕基, 田中 秀和, 横田 駿, 柴田 奈緒, 向井 淳, 須藤 麻貴子, 曽我 文隆, 堂國 久美子, 羽渓 優, 松添 弘樹, 畑澤 圭子, 久松 恵理子, 松本 賢亮, 平田 健一
    (一社)日本循環器学会, 2018年03月, 日本循環器学会学術集会抄録集, 82回, PJ078 - 1, 英語

  • Yutaka Hatani, Hidekazu Tanaka, Yasuhide Mochizuki, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Keiko Ryo-Koriyama, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    OBJECTIVES: The closure of atrial septal defect (ASD) results in normalized left ventricular (LV) and right ventricular (RV) geometry, and can increase LV stroke volume (LVSV), but the parameters associated with this increase after the closure of ASD remain uncertain. METHODS: Seventy ASD patients, who underwent transcatheter closure, were studied. Their mean age was 57.80 ± 16.88 years, 42 (60%) were female, and LV ejection fraction (LVEF) was 66.76% ± 7.91% (all ≥55%). Transthoracic echocardiography was performed before and 3 months after the procedure. Global longitudinal strain (GLS) was determined as the average peak speckle tracking strain of 18 segments from the 3 standard apical views, LV dispersion was defined as standard deviation of time-to-peak strain from the same views, and RV systolic function was calculated by averaging the 3-regional peak speckle tracking longitudinal strains from the RV free wall. A significant relative increase in LVSV between before and 3 months after the closure was defined as ∆LVSV ≥15%. Twenty age-, gender-, and LVEF-matched controls served as the control group. RESULTS: Global longitudinal strain (GLS) and RV free wall strain were similar for ASD patients and controls, but LV dispersion in ASD patients was significantly larger. Global longitudinal strain (GLS) remained unchanged after transcatheter closure, whereas RV free wall strain and LV dispersion decreased significantly. An important finding of the multivariate logistic regression analysis showed that ∆LV dispersion was the only independent determinant of increased LVSV after the closure (OR 1.023; 95% CI 1.001-1.046; P < .01). CONCLUSIONS: The assessment of LV dispersion may well have clinical implications for better management of ASD patients after transcatheter closure.
    2018年02月, Echocardiography (Mount Kisco, N.Y.), 35(2) (2), 218 - 226, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Palliative Care based on Antemortem Diagnosis in a Case of Nonbacterial Thrombotic Endocarditis with Concomitant Repeated Systemic Embolization
    Shibata N, Matsumoto K, Kitamura S, Sakashita A, Kizawa Y, Tanaka H, Hirata KI
    2018年, Intern Med, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Nao Shibata, Kensuke Matsumoto, Takayoshi Toba, Shumpei Mori, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-Ichi Hirata
    This case report is about an 85-year-old woman with bicuspid aortic stenosis (AS). Although preoperative multimodality imaging showed challenging anatomical aspects, transcatheter aortic valve replacement (TAVR) was selected to be performed as a less invasive alternative treatment approach, owing to her comorbidity. Postoperative transesophageal echocardiography and multidetector-row computed tomography revealed the presence of "locked-in leaflet" caused by stent distortion due to pinching by calcified native leaflets, with nodular calcification preventing the full expansion of the valve, which resulted in moderate perivalvular leakage. This is the first reported case of bicuspid AS treated with TAVR that eventually resulted in "locked-in leaflet."
    2018年01月, Echocardiography (Mount Kisco, N.Y.), 35(1) (1), 110 - 113, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Naoki Tamada, Kazuhiko Nakayama, Yuto Shinkura, Kenichi Yanaka, Naoto Katayama, Takuya Okada, Masato Yamaguchi, Kensuke Matsumoto, Hidekazu Tanaka, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
    The patient was a 19-year-old woman who was diagnosed with patent ductus arteriosus complicating Eisenmenger syndrome at a previous medical institution. She was referred to our hospital and arranged for lung transplantation. She developed hemoptysis after the introduction of i.v. epoprostenol, which was administered as a bridging treatment while the patient awaited lung transplantation. She continued to suffer from recurrent hemoptysis, even after switching from i.v. epoprostenol to i.v. treprostinil. Angiography of the systemic and pulmonary arteries revealed the vessel responsible for the recurrent hemoptysis and pulmonary artery embolization was successfully performed. It is essential to identify the culprit vessel and physicians must not hesitate in performing embolization when patients develop lethal hemoptysis.
    2017年12月, Internal medicine (Tokyo, Japan), 56(24) (24), 3299 - 3304, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Kunihiko Kiuchi, Koji Fukuzawa, Shumpei Mori, Tatsuya Nishii, Kensuke Matsumoto, Hirotoshi Ichibori, Takashi Yamada
    Transvenous lead extraction (TLE) is performed to prevent deaths in patients with device infections. Intracardiac masses detected by echocardiography, i.e., "ghosts," are reported in 8% of patients after a TLE in retrospective studies and in 14% in prospective studies. We herein describe a case with unusual ghosts after a TLE. Three-dimensional computed tomography (3DCT) is useful for revealing all the details of unusual ghosts. In this case, the residual silicone insulation and "cast," including the fibrous sheath and severe calcifications could be visualized and differentiated by 3DCT.
    2017年12月, Journal of arrhythmia, 33(6) (6), 640 - 642, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yasuhide Mochizuki, Hidekazu Tanaka, Kensuke Matsumoto, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yoshiki Motoji, Keiko Ryo-Koriyama, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    Left ventricular (LV) diastolic dysfunction and longitudinal systolic dysfunction were identified in patients with diabetes mellitus (DM). This study's aim was to investigate the impact of LV longitudinal systolic function on LV diastolic function in DM patients with preserved LV ejection fraction (LVEF). We studied 177 DM patients with preserved LVEF (all ≥50%), and 82 age-, gender- and LVEF-matched healthy volunteers as control. Global longitudinal strain (GLS) was defined as the average peak strain of 18 segments from standard apical views, GLS <18% as subclinical LV systolic dysfunction (LVSD), and LV dispersion as the standard deviation of time-to-peak strain from the same views. For DM patients with LVSD (n = 74), E/A and E' were lower, and E/E' and isovolumic relaxation time (IVRT) were greater than for DM patients without LVSD (n = 103) and normal controls (n = 82). Moreover, these parameters were lower for DM patients without LVSD than for normal controls. Multivariate analysis revealed that GLS was a strong determinative factor for E' and E/E' (β = 0.30, p < 0.001 and β = -0.25, p < 0.001, respectively), as was LV dispersion for E-wave deceleration time and IVRT (β = 0.21, p = 0.002 and β = 0.30, p < 0.001, respectively) independently of age. For normal subjects, however, only age was associated with all LV diastolic parameters. In conclusions, in contrast to age-related LV diastolic dysfunction in normal subjects, in DM patients with preserved LVEF, LV diastolic function was associated with LV longitudinal systolic function and LV dispersion independently of age. Our findings have obvious clinical implications for the management of DM patients.
    2017年12月, The international journal of cardiovascular imaging, 33(12) (12), 1905 - 1914, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Toshiro Shinke, Hirotsugu Yamada, Yutaka Okita, Ken-Ichi Hirata
    BACKGROUND: Although aortic valve intervention is recommended for virtually all symptomatic patients with aortic stenosis (AS), how urgently the intervention should be performed remains controversial. The aim of this study was thus to determine whether the preload reserve in response to leg-positive pressure (LPP) maneuver could serve for decision-making for AS patients awaiting aortic valve intervention.Methods and Results:Sixty-eight patients with symptomatic AS, who were referred for aortic valve intervention, were recruited. Stroke volume (SV) was assessed by means of pulsed-wave Doppler, and the ratio between transmitral E wave and mitral annular velocity (e') was calculated to estimate ventricular filling pressure. While waiting for intervention, 11 patients experienced preoperative cardiac events. During acute preload stress, forward SV for patients without cardiac events increased significantly (from 43±9 to 49±10 mL/m2, P<0.01) along with a minimal change in filling pressure (E/e': from 20±8 to 21±9, NS). For patients with cardiac events, the Frank-Starling mechanism was significantly impaired (SVi: from 40±9 to 38±7 mL/m2, NS), while filling pressure increased to the critical level (E/e': from 24±8 to 31±8, P<0.001). Both the patients without flow reserve (∆SVi <4.5 mL/m2) and those without diastolic reserve (∆E/e' ≥2.9) exhibited significantly worse event-free survival than the others (P<0.05, respectively). CONCLUSIONS: Assessment of preload reserve during LPP stress could facilitate risk stratification of patients with severe AS waiting for aortic valve intervention.
    2017年11月, Circulation journal : official journal of the Japanese Circulation Society, 81(12) (12), 1927 - 1935, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Makiko Suto, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Kensuke Matsumoto, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    2017年11月, Cardiovascular diabetology, 16(1) (1), 145 - 145, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makiko Suto, Shumpei Mori, Tatsuya Nishii, Yu Izawa, Shinsuke Shimoyama, Hiroki Konishi, Kensuke Matsumoto, Hidekazu Tanaka, Ken-Ichi Hirata
    2017年11月, Echocardiography (Mount Kisco, N.Y.), 34(11) (11), 1721 - 1724, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hiroki Matsuzoe, Kensuke Matsumoto, Shumpei Mori, Takayoshi Toba, Hiroyuki Kawamori, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-Ichi Hirata
    2017年11月, Echocardiography (Mount Kisco, N.Y.), 34(11) (11), 1717 - 1720, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Junichi Ooka, Hidekazu Tanaka, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Kensuke Matsumoto, Koji Fukuzawa, Ken-Ichi Hirata
    Although right ventricular (RV) pacing is the only effective treatment for patients with symptomatic bradycardia, it creates left ventricular (LV) dyssynchrony, which can induce LV dysfunction and heart failure. The current criterion for consideration of cardiac resynchronization therapy (CRT) is LV ejection fraction (LVEF) ≤ 35%, but indication for CRT in patients required for RV pacing with LVEF > 35% remains unclear.We studied 40 patients, all LVEF ≥ 35%, who had undergone implantable cardioverter-defibrillator implantation with RV pacing < 5%. Echocardiography was performed at baseline and during RV pacing. LV dyssynchrony was defined as anteroseptal-to-posterior wall delay from the mid-LV short-axis view using two-dimensional speckle-tracking radial strain (significant: ≥ 130 ms). Patients were divided into two groups based on baseline LVEF: normal LVEF ( ≥ 50%; n = 20) and mildly reduced LVEF (35-50%; n = 20).LVEF and LV dyssynchrony in patients with mildly reduced LVEF deteriorated significantly during RV pacing compared to those in patients with normal LVEF. Moreover, changes in LV dyssynchrony during RV pacing significantly correlated with changes in LVEF (r = -0.44, P < 0.01). Multivariate logistic regression analysis showed that baseline LVEF was the only independent predictor and baseline LVEF < 48% predictive of significant LV dyssynchrony during RV pacing.The extent of RV pacing-induced LV dysfunction may be associated with baseline LV function. These adverse effects on patients with mildly reduced LVEF of 35-50% and indications for RV pacing due to bradycardia can thus be prevented by CRT.
    2017年10月, International heart journal, 58(5) (5), 724 - 730, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • 肺高血圧症患者における下肢陽圧負荷心エコー図検査の有用性
    佐野 浩之, 田中 秀和, 向井 淳, 須藤 麻貴子, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 松本 賢亮, 中山 和彦, 江本 憲昭, 平田 健一
    (一社)日本心臓病学会, 2017年09月, 日本心臓病学会学術集会抄録, 65回, P - 147, 日本語

  • Junichi Ooka, Hidekazu Tanaka, Yutaka Hatani, Yukio Tsuji, Ryo Takeshige, Shumpei Mori, Kensuke Matsumoto, Shigeo Hara, Hiroshi Tanaka, Yutaka Okita, Ken-Ichi Hirata
    2017年08月, Internal medicine (Tokyo, Japan), 56(16) (16), 2155 - 2158, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yu Izawa, Shumpei Mori, Tatsuya Nishii, Hiroki Matsuzoe, Hiroshi Imada, Hideya Suehiro, Kazuhiko Nakayama, Kensuke Matsumoto, Hidekazu Tanaka, Sei Fujiwara, Koji Fukuzawa, Ken-Ichi Hirata
    2017年07月, Echocardiography (Mount Kisco, N.Y.), 34(7) (7), 1073 - 1076, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hiroyuki Shimoura, Hidekazu Tanaka, Kensuke Matsumoto, Yasuhide Mochizuki, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Keiko Ryo-Koriyama, Ken-Ichi Hirata
    Left ventricular (LV) hypertrophy (LVH) is an independent cardiovascular risk factor for heart failure (HF) patients. The renin-angiotensin system plays a key role in LVH, and since olmesartan increases plasma angiotensin-(1-7) through an increase in angiotensin-converting enzyme-related carboxypeptidase (ACE2) expression, it was hypothesized to reduce LVH, unlike other angiotensin II receptor blockers (ARBs). The objective of this study was therefore to investigate the effects of a changeover from other ARBs to olmesartan on LVH in HF patients. Participants enrolled in this prospective trial were 64 outpatients with stable HF who had received ARBs other than olmesartan for more than 1 year (age: 59 ± 13 years). Transthoracic echocardiography and laboratory tests were performed before and 6 months after administration of olmesartan. Other drugs were not changed during follow-up. The primary end point was defined as a change in LV mass index (LVMI) from baseline up to 6 months after administration of olmesartan. No significant changes were observed in blood pressures and heart rate after administration of olmesartan. LVMI showed a significant decrease from 119 ± 38 to 110 ± 24 g/m2 (p = 0.007) 6 months after administration of olmesartan, and further decreased from 110 ± 24 to 103 ± 35 g/m2 (p = 0.0003) after 12 months. Moreover, this reduction tended to be more prominent in patients with LVH. In conclusions, LVH in HF patients was reduced by the changeover to olmesartan. This finding may well have clinical implications for better management of HF patients.
    2017年05月, Heart and vessels, 32(5) (5), 584 - 590, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shumpei Mori, Robert H Anderson, Tatsuya Nishii, Kensuke Matsumoto, Rohit S. Loomba
    Medknow Publications, 2017年05月, Annals of Pediatric Cardiology, 10(2) (2), 175 - 186, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Osamu Imataki, Kensuke Matsumoto, Makiko Uemura
    Springer Verlag, 2017年04月, Journal of Cancer Research and Clinical Oncology, 143(4) (4), 709 - 715, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 駆出率が保持されたリンパ腫患者における左室機能と癌の病期および合併症との関連性(Association of Left Ventricular Function with Stages of Cancer and Concomitant Diseases in Patients with Lymphoma and Preserved Ejection Fraction)
    畑澤 圭子, 田中 秀和, 野中 顕子, 大菊 麻貴子, 向井 淳, 久松 恵理子, 曽我 文隆, 高田 裕基, 堂國 久美子, 羽渓 優, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 望月 泰秀, 郡山 恵子, 松本 賢亮, 平田 健一
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PJ - 232, 英語

  • 糖尿病において肥満が左室長軸方向の機能に及ぼす影響(Impact of Obesity on Left Ventricular Longitudinal Function in Diabetes Mellitus)
    須藤 麻貴子, 田中 秀和, 望月 泰秀, 向井 淳, 久松 恵理子, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 郡山 恵子, 松本 賢亮, 平田 健一
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PJ - 503, 英語

  • 重症大動脈弁逆流症を有し左室駆出率が保持されている患者の術後左室機能不全の予測における心室-動脈カップリングの有用性(Utility of Ventriculo-arterial Coupling to Predict Post-operative Left Ventricular dysfunction in Patients with Severe Aortic Regurgitation and Preserved Left ventricular Ejection Fraction)
    大岡 順一, 田中 秀和, 松本 賢亮, 須藤 麻貴子, 向井 淳, 久松 恵理子, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 望月 泰秀, 郡山 恵子, 平田 健一
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PJ - 506, 英語

  • Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Yasuhide Mochizuki, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Keiko Ryo-Koriyama, Kazuhiko Nakayama, Kensuke Matsumoto, Noriaki Emoto, Ken-Ichi Hirata
    2017年03月, The international journal of cardiovascular imaging, 33(3) (3), 313 - 321, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Significant prognostic impact of improvement in ventriculo-arterial coupling induced by dobutamine stress on cardiovascular outcome for patients with dilated cardiomyopathy.
    Kensuke Matsumoto, Hidekazu Tanaka, Junichi Ooka, Yoshiki Motoji, Takuma Sawa, Yasuhide Mochizuki, Keiko Ryo, Kazuhiro Tatsumi, Ken-Ichi Hirata
    AIMS: The purpose of this study was to investigate the prognostic impact of the changes in ventriculo-arterial (VA) coupling during dobutamine stress on the cardiovascular events for patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: For this study, 89 DCM patients with ejection fractions of 32 ± 10% and 30 normal controls were recruited. Ees was estimated with the non-invasive single-beat method using three-dimensional echocardiography at rest and during dobutamine stress (20 μg/kg/min). Effective arterial elastance (Ea) was calculated as left ventricular (LV) end-systolic pressure divided by stroke volume, and VA coupling was calculated as Ea/Ees. Event-free survival was then tracked for 32 months. At baseline, VA coupling was far from optimal in patients with DCM compared with controls (Ea/Ees: 2.49 ± 1.02 vs. 1.04 ± 0.21, P < 0.001). During the follow-up period, 22 patients developed adverse cardiovascular events. During dobutamine stress, VA coupling was significantly improved in patients without cardiovascular events (from 2.47 ± 1.09 to 1.59 ± 0.68, P < 0.001), but remained unchanged in those with cardiovascular events. A multivariate Cox proportional-hazards analysis revealed that age, NYHA functional class (>II), and the change in VA coupling during dobutamine stress were the independent determinants of cardiovascular events (P < 0.05, <0.01, and <0.001, respectively). When patients were divided into two subgroups based on the finding of receiver operating characteristic curve analysis, patients with good VA coupling reserve (cut-off: change in VA coupling> 0.29) showed significantly favourable event-free survival than those with poor VA coupling reserve (P < 0.001). CONCLUSIONS: Improvement in VA coupling during dobutamine stress is an important determinant of cardiovascular outcome for patients with DCM.
    2016年11月, European heart journal cardiovascular Imaging, 17(11) (11), 1296 - 1304, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 症候性大動脈弁狭窄症患者における前負荷予備能の検討
    松添 弘樹, 松本 賢亮, 田中 秀和, 曽我 文隆, 高田 裕基, 羽渓 優, 畑澤 圭子, 下浦 広之, 大岡 順一, 佐野 浩之, 佐和 琢磨, 望月 泰秀, 郡山 恵子, 平田 健一
    (一社)日本心臓病学会, 2016年09月, 日本心臓病学会学術集会抄録, 64回, O - 081, 日本語

  • 肺高血圧症患者における治療後の右室reverse remodelingを予測する因子の検討
    佐野 浩之, 田中 秀和, 福田 優子, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 下浦 広之, 佐和 琢磨, 望月 泰秀, 郡山 恵子, 松本 賢亮, 江本 憲昭, 平田 健一
    (一社)日本心臓病学会, 2016年09月, 日本心臓病学会学術集会抄録, 64回, P - 083, 日本語

  • 2次元スペックルトラッキング法でみた左室-左房連関に及ぼす糖尿病性腎症の影響
    望月 泰秀, 田中 秀和, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 佐野 浩之, 下浦 広之, 郡山 恵子, 松本 賢亮, 平田 健一
    (一社)日本心臓病学会, 2016年09月, 日本心臓病学会学術集会抄録, 64回, P - 282, 日本語

  • Yasuhide Mochizuki, Hidekazu Tanaka, Kensuke Matsumoto, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Keiko Ryo-Koriyama, Yushi Hirota, Wataru Ogawa, Ken-Ichi Hirata
    BACKGROUND: Diabetic nephropathy is independently associated with longitudinal systolic dysfunction of the left ventricle (LV) in asymptomatic diabetes mellitus (DM) patients with preserved LV ejection fraction (LVEF). However, the effect of diabetic nephropathy on left atrial (LA) function remains unknown. METHODS AND RESULTS: We studied 198 asymptomatic DM patients (LVEF ≥50%). Diabetic nephropathy was defined as a protein level higher than for micro-albuminuria. LV global longitudinal strain (GLS) and LA strain were analyzed by 2D speckle-tracking; 69 age-, sex-, and LVEF-matched controls were also studied. GLS and LA strain in systole (LAS-s) decreased significantly from normal controls to DM patients without (n=137) and with nephropathy (n=61), in that order. Furthermore, GLS, LAS-s, and LA strain in late diastole (LAS-a) were significantly lower in DM patients with macro-albuminuria (n=19) than in those with micro-albuminuria (n=42). Although 1 multivariate regression analysis identified albuminuria as an independent determinative factor of LAS-s among other relevant clinical background factors (β=-0.16, P=0.002), another multivariate regression model for LAS-s+GLS (β=0.40, P<0.001) showed that albuminuria was not a significant factor (β=-0.02, P=0.68). Similarly, another multivariate regression model including GLS (β=0.32, P<0.001) demonstrated that clinical features relevant for LAS-a, except for age, were not independent determinants of LAS-a. CONCLUSIONS: The cross-linked association of LA strain with GLS and albuminuria may be important for better understanding the development of diabetic cardiomyopathy. (Circ J 2016; 80: 1957-1964).
    2016年08月, Circulation journal : official journal of the Japanese Circulation Society, 80(9) (9), 1957 - 64, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yuko Fukuda, Hidekazu Tanaka, Keiko Ryo-Koriyama, Yoshiki Motoji, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Hiromi Toki, Takuma Sawa, Yasuhide Mochizuki, Kensuke Matsumoto, Noriaki Emoto, Ken-Ichi Hirata
    BACKGROUND: Right ventricular (RV) systolic function is one of the most important determinants of outcome for pulmonary hypertension (PH) patients, but the factors influencing prognosis vary widely. Elevated right atrial (RA) pressure is reported to be one of these prognostic factors, but its functional importance has scarcely been assessed. METHODS: Eighty-two PH patients, all of whom underwent echocardiography and right heart catheterization, were recruited. RV function was assessed by two-dimensional speckle tracking longitudinal strain from RV-focused apical four-chamber view and calculated by averaging the three regional peak strains from the RV free wall (RV-free). RA function was determined as the sum of three peak strain values comprising reservoir, conduit, and contractile function (sum of RA strain). RESULTS: Sum of RA strain correlated significantly with hemodynamic parameters such as mean right atrial pressure (r = -0.35, P = 0.002) and end-diastolic RV pressure (r = -0.29, P = 0.008). Patients with sum of RA strain ≥30.2% experienced more favorable outcomes than those with sum of RA strain <30.2% (log-rank P = 0.001). Furthermore, patients with impaired RV systolic function (RV-free <20%) and RA function (sum of RA strain <30.2%) showed the worst outcome (P = 0.001). A sequential Cox model based on clinical variables (χ(2) = 5.8) was improved by addition of RV-free (χ(2) = 8.7; P < 0.05) and further improved by addition of sum of RA strain (χ(2) = 12.0; P < 0.01). CONCLUSION: Right atrial strain appears to be a valuable additive factor for predicting outcomes for PH patients, and comprehensive functional assessment of right-sided heart using speckle tracking strain may have potential clinical implications for better management of PH patients.
    2016年07月, Echocardiography (Mount Kisco, N.Y.), 33(7) (7), 1001 - 8, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masanaga Tsujimoto, Hidekazu Tanaka, Kensuke Matsumoto, Takeshi Inoue, Yutaka Okita, Ken-Ichi Hirata
    2016年07月, Echocardiography (Mount Kisco, N.Y.), 33(7) (7), 1105 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 経カテーテル閉鎖術後の心房中隔欠損症患者の両室相互作用(Bi-ventricular Interaction in Patients with Atrial Septal Defect Following Transcatheter Closure)
    Hatani Yutaka, Tanaka Hidekazu, Sawa Takuma, Takada Hiroki, Soga Fumitaka, Hatazawa Keiko, Dokuni Kumiko, Matsuzoe Hiroki, Shimoura Hiroyuki, Ooka Junichi, Sano Hiroyuki, Mochizuki Yasuhide, Ryo Keiko, Matsumoto Kensuke, Ohtake Hiromasa, Shinke Toshiro, Hirata Ken-ichi
    (一社)日本循環器学会, 2016年03月, Circulation Journal, 80(Suppl.I) (Suppl.I), 1282 - 1282, 英語

  • 心不全患者の左室肥大に対する他のangiotensin II receptor blockerからolmesartanへの切換の効果(Effects of a Change-Over from Other Angiotensin II Receptor Blockers to Olmesartan on Left Ventricular Hypertrophy in Heart Failure Patients)
    Shimoura Hiroyuki, Tanaka Hidekazu, Matsumoto Kensuke, Mochizuki Yasuhide, Takada Hiroki, Soga Fumitaka, Hatani Yutaka, Hatazawa Keiko, Dokuni Kumiko, Matsuzoe Hiroki, Ooka Junichi, Sano Hiroyuki, Sawa Takuma, Ryo Keiko, Hirata Ken-ichi
    (一社)日本循環器学会, 2016年03月, Circulation Journal, 80(Suppl.I) (Suppl.I), 1472 - 1472, 英語

  • Hiroki Matsuzoe, Hidekazu Tanaka, Kensuke Matsumoto, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Koji Fukuzawa, Akihiro Yoshida, Ken-ichi Hirata
    AIMS: Current guidelines recommend implantation of prophylactic implantable cardioverter-defibrillators (ICD) in patients with left ventricular (LV) ejection fraction (EF) <35%. We explored the prognostic factors of fatal ventricular arrhythmias for heart failure (HF) patients with LVEF ≥35%. METHODS AND RESULTS: We retrospectively studied 72 patients with LVEF of 52 ± 12% (all ≥35%) who had undergone ICD implantation. Heterogeneity of LV regional myocardial contraction was defined as standard deviation of peak strain (dyssynergy index) and time-to-peak strain (dispersion index) from 18 LV segments determined by speckle tracking. Fatal ventricular arrhythmias with appropriate ICD therapy occurred in 34 patients (47%) during a median follow-up of 17 months. Receiver operating characteristic curve analysis identified dispersion index ≥101 ms and dyssynergy index ≥6.1% as predictors of fatal ventricular arrhythmias (P = 0.004 and P = 0.0001, respectively). In addition, the combination of dispersion index ≥101 ms and dyssynergy index ≥6.1% was the most predictive of fatal ventricular arrhythmias with a sensitivity of 77%, specificity of 79%, and area under the curve of 0.795 (P < 0.0001). A sequential Cox model based on clinical and conventional echocardiographic variables including age, gender, HF aetiology, and LVEF (χ(2) = 4.8) was improved, but not statistically significant (χ(2) = 4.9; P = 0.82), by addition of global longitudinal strain, whereas improvement by the addition of the dispersion index (χ(2) = 8.9; P = 0.04) and further improvement by the addition of the dyssynergy index (χ(2) = 20.2; P < 0.005). CONCLUSION: Combined assessment of LV dyssynergy and dispersion can enhance predictive capability for fatal ventricular arrhythmias in patients with LVEF ≥35% and may have potential for better management of such patients.
    2016年03月, European heart journal cardiovascular Imaging, 17(3) (3), 334 - 42, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Hiroyuki Sano, Keiko Ryo, Takuma Sawa, Tatsuya Miyoshi, Junichi Imanishi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    BACKGROUND: Current guidelines recommend the routine use of tricuspid annular plane systolic excursion (TAPSE) as a simple method for estimating right ventricular (RV) function. However, when ventricular apical longitudinal rotation (apical-LR) occurs in pulmonary hypertension (PH) patients, it may result in overestimated TAPSE. METHODS: We studied 105 patients with PH defined as mean pulmonary artery pressure >25 mmHg at rest measured by right heart cardiac catheterization. TAPSE was defined as the maximum displacement during systole in the RV-focused apical four-chamber view. RV free-wall longitudinal speckle tracking strain (RV-free) was calculated by averaging 3 regional peak systolic strains. The apical-LR was measured at the peak rotation in the apical region including both left and right ventricle. The eccentricity index (EI) was defined as the ratio of the length of 2 perpendicular minor-axis diameters, one of which bisected and was perpendicular to the interventricular septum, and was obtained at end-systole (EI-sys) and end-diastole (EI-dia). Twenty age-, gender-, and left ventricular ejection fraction-matched normal controls were studied for comparison. RESULTS: The apical-LR in PH patients was significantly lower than that in normal controls (-3.4 ± 2.7° vs. -1.3 ± 1.9°, P = 0.001). Simple linear regression analysis showed that gender, TAPSE, EI-sys, and EI-dia/EI-sys were associated with apical-LR, but RV-free was not. Multiple regression analysis demonstrated that gender, EI-dia/EI-sys, and TAPSE were independent determinants of apical-LR. CONCLUSIONS: TAPSE may be overestimated in PH patients with clockwise rotation resulting from left ventricular compression. TAPSE should thus be evaluated carefully in PH patients with marked apical rotation.
    2016年02月, Echocardiography (Mount Kisco, N.Y.), 33(2) (2), 207 - 15, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用について(Ventricular Interaction in Patients with Atrial Septal Defect Following Transcatheter Closure)
    羽渓 優, 松本 賢亮, 田中 秀和, 佐和 琢磨, 高田 裕基, 曽我 文隆, 畑澤 圭子, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 望月 泰秀, 漁 恵子, 新家 俊郎, 平田 健一
    (一社)日本成人先天性心疾患学会, 2016年01月, 日本成人先天性心疾患学会雑誌, 5(1) (1), 135 - 135, 英語

  • Takuma Sawa, Hidekazu Tanaka, Yoshiki Motoji, Mana Hiraishi, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-ichi Hirata
    BACKGROUND: Transcatheter closure is a well-established treatment for patients with atrial septal defect (ASD), but long-term outcome prognostic factors for adults have not been fully identified yet. METHODS: Forty-nine consecutive patients (age 57 ± 17 years, 59% female), who underwent transcatheter closure of ASD, were the subjects of this study. Transthoracic echocardiography was performed before and midterm after the procedure (6 ± 1 months). Isovolumic contraction peak velocity (IVV) was measured at the lateral site of the tricuspid annulus using spectral tissue Doppler imaging, and ΔIVV was determined as the absolute change at midterm follow-up. Long-term unfavorable outcome events, tracked for 19 ± 9 months, were prespecified as primary end points comprising newly developed atrial fibrillation, cerebral infarction, and heart failure. RESULTS: Symptomatic improvement, defined as an improvement in New York Heart Association functional class by one grade or more at midterm after the procedure, was observed in 24 patients (49%), and the remaining 25 (51%) were classified as not symptomatically improved. ΔIVV was significantly larger for patients with symptomatic improvement than for those without (from 11.5 ± 4.3 cm/s to 14.2 ± 3.7 cm/s vs. from 11.8 ± 4.1 cm/s to 12.5 ± 2.9 cm/s; P = 0.045). An important finding of the multivariate Cox proportional-hazards analysis was that only ΔIVV was independently associated with cardiovascular events (HR: 0.701; 95% CI 0.537-0.916; P = 0.01). Kaplan-Meier analysis showed that more patients with enhanced ΔIVV presented with favorable long-term outcome than those with diminished ΔIVV (log-rank P = 0.0001). CONCLUSIONS: IVV, which is a less volume-sensitive parameter, can be useful for comprehensive evaluation of ASD patients referred for transcatheter closure.
    2016年01月, Echocardiography (Mount Kisco, N.Y.), 33(1) (1), 23 - 9, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Kumiko Dokuni, Hidekazu Tanaka, Yasuhide Mochizuki, Kensuke Matsumoto, Yutaka Okita, Ken-Ichi Hirata
    2015年12月, Echocardiography (Mount Kisco, N.Y.), 32(12) (12), 1889 - 90, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Takuma Sawa, Hidekazu Tanaka, Yoshiki Motoji, Mana Hiraishi, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-Ichi Hirata
    2015年11月, Echocardiography (Mount Kisco, N.Y.), 32(11) (11), 1743 - 1743, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Kensuke Matsumoto, Hidekazu Tanaka, Akira Onishi, Yoshiki Motoji, Kazuhiro Tatsumi, Takuma Sawa, Tatsuya Miyoshi, Junichi Imanishi, Yasuhide Mochizuki, Ken-ichi Hirata
    AIMS: Right ventricular (RV) as well as left ventricular (LV) function has been recognized as an important prognostic factor for heart failure patients. Our objective was thus to investigate the prognostic significance of combined assessment of bi-ventricular functional reserve for patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: We studied 104 DCM patients with ejection fractions (EF) of 32 ± 9%, and speckle-tracking echocardiography was used to assess both RV and LV contractile reserve under dobutamine stress (20 µg/kg/min). RV contractile function was measured as peak global longitudinal strain (GLS) from the RV free wall (RV-free), and LV function as global circumferential strain (GCS) and GLS, respectively. Event-free survival was then tracked for 17 months. Twenty-one patients (20%) developed cardiovascular events. A multivariate Cox proportional-hazards analysis revealed that the baseline EF, E/A, and the relative change in EF (ΔEF), in GCS (ΔGCS), and in RV-free (ΔRV-free) during dobutamine stress were the independent predictors of cardiovascular events (P < 0.001, <0.05, <0.01, <0.05, and <0.01, respectively). A Cox model based on baseline clinical and echocardiographic variables (χ(2) = 23.6) was improved by the addition of LV contractile reserve parameters (plus ΔGCS and ΔEF) (χ(2) = 49.1; P < 0.001) and further improved by adding RV contractile reserve (plus ΔRV-free) (χ(2) = 60.3, P < 0.001). CONCLUSION: Assessment of RV contractile reserve during dobutamine stress offers a significantly better prognostic value for patients with DCM. Bi-ventricular contractile reserve may be required for a favourable outcome, so that estimation of RV contractile reserve should be considered part of a comprehensive functional assessment of these patients.
    2015年11月, European heart journal cardiovascular Imaging, 16(11) (11), 1213 - 23, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 糖尿病性心筋症と糖尿病性神経症との関連性
    望月 泰秀, 田中 秀和, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 大岡 順一, 佐和 琢磨, 元地 由樹, 漁 恵子, 松本 賢亮, 平田 健一
    (一社)日本心臓病学会, 2015年09月, 日本心臓病学会学術集会抄録, 63回, 346 - 346, 日本語

  • 軽度左室収縮能低下患者における右室ペーシングの影響
    大岡 順一, 田中 秀和, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 佐和 琢磨, 元地 由樹, 望月 泰秀, 漁 恵子, 松本 賢亮, 福沢 公二, 平田 健一
    (一社)日本心臓病学会, 2015年09月, 日本心臓病学会学術集会抄録, 63回, 712 - 712, 日本語

  • 右室中隔ペーシングにより高度左室心筋障害ならびに三尖弁閉鎖不全症を来した1例
    羽渓 優, 田中 秀和, 堂國 久美子, 畑澤 圭子, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 土岐 啓己, 佐和 琢磨, 望月 泰秀, 元地 由樹, 漁 恵子, 松本 賢亮, 福沢 公二, 平田 健一
    (一社)日本心臓病学会, 2015年09月, 日本心臓病学会学術集会抄録, 63回, 1127 - 1127, 日本語

  • Yasuhide Mochizuki, Hidekazu Tanaka, Kensuke Matsumoto, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yoshiki Motoji, Keiko Ryo, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata
    BACKGROUND: Subclinical left ventricular (LV) longitudinal myocardial systolic dysfunction occurs in patients with diabetes mellitus (DM) and preserved LV ejection fraction (LVEF), and is closely related to DM-related complications. However, the association of diabetic neuropathy (DN) with subclinical LV systolic longitudinal dysfunction in such patients has not been fully clarified. METHODS: The subjects of this study were 112 consecutive DM patients with preserved LVEF (all ≥50%) without coronary artery disease and overt heart failure (aged 59 ± 14 years; 60 women, 52 men). Global longitudinal strain (GLS) was determined as the average peak strain of 18 segments from the three standard apical views, and was expressed as an absolute value. DN was diagnosed by experienced diabetologists. Median, ulnar, and sural nerves were subjected to motor and sensory nerve conduction studies. F-wave latency was defined as the minimum F-wave latency after a total of 16 stimulations of the tibial nerve. RESULTS: Forty-one (37%) patients were clinically diagnosed with DN. LV functions of DM patients with and without DN were similar except for GLS being significantly smaller in patients with than in patients without DN (18 ± 2% vs. 20 ± 2%, p < 0.001). It was noteworthy that, of the parameters for the nerve conduction study, only F-wave latency correlated with GLS (r = -0.34, p < 0.001), and also was identified as an independent determinative value of GLS in a multivariate linear regression model (β = -0.25, p = 0.001) even after adjustment for other closely related GLS factors. CONCLUSIONS: Monitoring of F-wave latency may aid early detection of not only DN but also subclinical LV dysfunction. Joint planning of assessment by diabetologists and cardiologists is therefore advisable for better management of DM patients.
    2015年05月, Cardiovascular diabetology, 14, 47 - 47, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junichi Imanishi, Hidekazu Tanaka, Takuma Sawa, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Ken-ichi Hirata
    BACKGROUND: Identification of heart failure (HF) symptoms in patients with severe aortic stenosis (AS) and preserved left ventricular (LV) ejection fraction (EF) is clinically important, but assessment of HF symptoms is challenging. It was recently reported that resting left atrium (LA) functions are related to exercise performance and are also important prognostic markers for patients with HF. The aim of this study was to assess the association of the HF symptoms with LA function in patients with severe AS and preserved LVEF. METHODS: We retrospectively studied 40 patients with severe AS and preserved LVEF (all ≥50%) who were referred for aortic valve replacement (AVR). LA reservoir (SR-LAs), conduit (SR-LAe), and booster-pump (SR-LAa) functions were determined as the averaged global LA speckle tracking longitudinal strain rate from apical four- and two-chamber views. Twenty patients were symptomatic and 20 asymptomatic. RESULTS: Aortic stenosis severity was similar for the 2 groups. Symptomatic status was associated with age, LV mass index, hemoglobin, B-type natriuretic peptide, LV end-systolic volume index, LVEF, LA volume index, SR-LAs, SR-LAe, and SR-LAa. Importantly, multivariate logistic regression analysis revealed that SR-LAa was the only independent determinant of symptomatic status (OR = 0.242, P = 0.002). Furthermore, significant improvement of SR-LAa was observed along with the reduction in LA volume index and LV mass index after AVR. CONCLUSIONS: SR-LAa was found to be associated with the HF symptoms. Characterization of LA booster-pump function may be useful for the assessment of the symptomatic status in patients with severe AS patients and limited physical activity.
    2015年05月, Echocardiography (Mount Kisco, N.Y.), 32(5) (5), 758 - 67, 英語, 国際誌
    [査読有り]

  • Kumiko Dokuni, Kensuke Matsumoto, Hidekazu Tanaka, Yutaka Okita, Ken-ichi Hirata
    2015年05月, European heart journal cardiovascular Imaging, 16(5) (5), 572 - 572, 英語, 国際誌
    [査読有り]

  • Yasuhide Mochizuki, Hidekazu Tanaka, Kensuke Matsumoto, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yoshiki Motoji, Keiko Ryo, Yushi Hirota, Wataru Ogawa, Ken-ichi Hirata
    BACKGROUND: Left ventricular (LV) longitudinal systolic dysfunction has been identified even in asymptomatic patients with diabetes mellitus (DM) and preserved LV ejection fraction (LVEF). However, its relevant clinical features have not been fully evaluated. METHODS: We studied 144 asymptomatic DM patients without coronary artery disease. Their mean age was 57 ± 15 years, 79 (55%) were female, and mean LVEF was 66 ± 4% (all ≥50%). Global longitudinal strain (GLS) was determined as the average peak strain of 18 segments from the three standard apical views, and was expressed as an absolute value. With the pre-defined cutoff for subclinical LV systolic dysfunction in DM patients with preserved LVEF set at GLS < 18%, this dysfunction was detected in 53 patients (37%). RESULTS: Multivariate logistic regression analysis revealed that type 2 DM, hypertriglyceridemia, overweight/obesity, nephropathy and neuropathy were independently associated with GLS < 18%, with nephropathy being the highest risk factor (OR: 5.26; 95% CI 2.111-13.12, p < 0.001). For sequential logistic regression models, a model based on clinical variables including gender, type 2 DM and DM duration (χ(2) = 24.1) was improved by addition of overweight/obesity and hypertriglyceridemia (χ(2) = 45.6, p < 0.001), and further improved by addition of nephropathy and neuropathy (χ(2) = 70.2, p < 0.001) as variables. Furthermore, albuminuria significantly correlated with GLS (r = -0.51, p < 0.001), and a multivariate regression model showed it to be the factor most closely associated with GLS (β = -0.33, p < 0.001). CONCLUSIONS: Diabetic complications, hypertriglyceridemia and overweight/obesity were closely associated with early stage of LV systolic longitudinal myocardial dysfunction in asymptomatic DM patients with preserved LVEF. Our findings can be clinically noticeable for the management of DM patients.
    2015年04月, Cardiovascular diabetology, 14, 37 - 37, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Hiroyuki Sano, Keiko Ryo, Junichi Imanishi, Tatsuya Miyoshi, Takuma Sawa, Yasuhide Mochizuki, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    Although impaired right ventricular (RV) performance has been associated with adverse outcomes for pulmonary hypertension (PH) patients, the relationship between bi-ventricular interdependence and outcomes is not yet fully understood. We studied 96 PH patients. RV systolic function was assessed by means of RV free-wall longitudinal speckle-tracking strain (RV-free), and left ventricular (LV) filling as early diastolic transmitral flow velocity (TMF-E). RV-free ≤19 % and TMF-E <60 cm/s were adopted as pre-defined cut-offs for RV systolic dysfunction and LV under-filling, respectively, associated with worse outcomes. Long-term outcome was tracked over 2.2 years. RV-free correlated significantly with TMF-E (r = 0.57, p < 0.001).TMF-E and RV-free were significantly lower in patients with than in those without cardiac events. RV systolic dysfunction and LV under-filling was observed in 35 patients. These features were associated with worse long-term survival compared to other sub-groups (log-rank p = 0.012). A sequential Cox model based on clinical variables including world health organization functional class IV and brain natriuretic peptide >150 pg/dl (χ(2) = 1.2) was improved by the addition of RV-free (χ(2) = 5.5, p = 0.04) as well as of TMF-E (χ(2) = 11.5, p = 0.01). In conclusions, RV systolic function was shown to correlate significantly with LV filling in PH patients. In addition, not only assessment of RV systolic function, but also of a combined bi-ventricular parameter comprising RV systolic function and LV filling may well have clinical implications for more successful management of PH patients.
    2015年04月, The international journal of cardiovascular imaging, 31(4) (4), 691 - 8, 英語, 国際誌
    [査読有り]

  • Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Takuma Sawa, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Noriaki Emoto, Ken-Ichi Hirata
    BACKGROUND: Right ventricular (RV) dysfunction in pulmonary hypertension (PH) is linked to adverse outcomes, but this response is considered heterogeneous because it can be associated with multiple factors. METHODS: RV function of 51 PH patients was calculated by averaging peak speckle-tracking longitudinal strain from RV free-wall (RV-free), and the cutoff for RV dysfunction was predefined as RV-free ≤ 19%. Right-sided heart remodelling was assessed in terms of RV end-systolic area (RVESA) and right atrial (RA) area (RA-area). Midterm reverse remodelling was defined as a relative decrease in RVESA (ΔRVESA) and RA-area (ΔRA-area) of at least 15% at 5.7 ± 4.0 months after introduction of pulmonary artery hypertension-specific drugs. Long-term outcome was tracked for 3.0 ± 2.0 years. RESULTS: Patients with midterm RV and RA reverse remodelling showed more favourable long-term outcomes than those without (P = 0.01, P = 0.047, respectively). Sequential Cox models showed that a model based on hemodynamic parameters (χ(2) = 0.3) was improved by the addition of RV-free (χ(2) = 6.4; P = 0.01), and further improved by addition of ΔRVESA and ΔRA-area (χ(2) = 28.2; P < 0.001). Furthermore, preservation of baseline RV function and midterm reverse remodelling in right-sided heart was associated with an optimal outcome: a survival rate of 100%. In contrast, absence of midterm reverse remodelling in the right-sided heart of patients with impaired baseline RV function was associated with significantly worse outcome with a survival rate of 33% (P = 0.01). CONCLUSIONS: RV function and echocardiographic right-heart reverse remodelling with therapy improves the prediction of long-term outcomes for PH patients over standard hemodynamic indices.
    2015年04月, The Canadian journal of cardiology, 31(4) (4), 529 - 36, 英語, 国際誌
    [査読有り]

  • 高電位冠状静脈洞ペーシングは駆出率低下患者の左室機械的同期不全を改善した(High Voltage Coronary Sinus Pacing Improved Left Ventricular Mechanical Dyssynchrony in Patients with Reduced Ejection Fraction)
    Tatsumi Kazuhiro, Tanaka Hidekazu, Matsumoto Kensuke, Inomata Kumiko, Hatani Yu, Hatazawa Keiko, Matsuzoe Hiroki, Ooka Junichi, Sano Hiroyuki, Shimoura Hiroyuki, Toki Hiromi, Sawa Takuma, Motoji Yoshiki, Mochizuki Yasuhide, Fukuda Yuko, Norisada Kazuko, Yoshida Akihiro, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 793 - 793, 英語

  • 右室機能と中期的逆リモデリングを組み合わせることで肺高血圧症患者の内科治療後の転帰に関する予後予測能は向上する(Combining of Right Ventricular Function with Mid-Term Reverse Remodeling Enhances Prognostic Capability for Pulmonary Hypertension Patient Outcome after Medical Treatment)
    Sano Hiroyuki, Tanaka Hidekazu, Motoji Yoshiki, Fukuda Yuko, Doukuni Kumiko, Hatani Yutaka, Hatazawa Keiko, Matsuzoe Hiroki, Toki Hiromi, Shimoura Hiroyuki, Ooka Junichi, Sawa Takuma, Mochizuki Yasuhide, Ryo Keiko, Matsumoto Kensuke, Emoto Noriaki, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 1327 - 1327, 英語

  • 成人心房中隔欠損に対する経カテーテル的閉鎖後症例の状態評価における等容性収縮期ピーク速度の有用性(Utility of Isovolumic Contraction Peak Velocity for Evaluation of Patient Status after Transcatheter Closure of Atrial Septal Defect in Adults)
    Sawa Takuma, Tanaka Hidekazu, Hiraishi Mana, Motoji Yoshiki, Dokuni Kumiko, Hatani Yutaka, Hatazawa Keiko, Matsuzoe Hiroki, Toki Hiromi, Shimoura Hiroyuki, Ooka Junichi, Sano Hiroyuki, Mochizuki Yasuhide, Ryo Keiko, Matsumoto Kensuke, Shinke Toshiro, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 1422 - 1422, 英語

  • 左室駆出率が保持された糖尿病患者における微小血管合併症の左室長軸方向機能との関連性(Association of Microvascular Complications with Left Ventricular Longitudinal Function in Patients with Diabetes Mellitus and Preserved Left Ventricular Ejection Fraction)
    Mochizuki Yasuhide, Tanaka Hidekazu, Doukuni Kumiko, Hatani Yutaka, Hatazawa Keiko, Matsuzoe Hiroki, Toki Hiromi, Shimoura Hiroyuki, Ooka Junichi, Sano Hiroyuki, Sawa Takuma, Motoji Yoshiki, Ryo Keiko, Matsumoto Kensuke, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 1630 - 1630, 英語

  • 駆出率が軽度低下した患者における致死的心室性不整脈の決定因子としての左室協調運動障害と分散(Left Ventricular Dyssynergy and Dispersion as Determinant Factors of Fatal Ventricular Arrhythmias in Patients with Mild Reduced Ejection Fraction)
    Matsuzoe Hiroki, Tanaka Hidekazu, Matsumoto Kensuke, Dokuni Kumiko, Hatani Yutaka, Hatazawa Keiko, Toki Hiromi, Shimoura Hiroyuki, Ooka Junichi, Sano Hiroyuki, Sawa Takuma, Motoji Yoshiki, Mochizuki Yasuhide, Ryo Keiko, Fukuzawa Koji, Yoshida Akihiro, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 2942 - 2942, 英語

  • 異なる治療戦略を選択した高齢者動脈管開存症の2症例
    松本 賢亮, 大岡 順一, 田中 秀和, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 土岐 啓己, 佐和 琢磨, 元地 由樹, 望月 泰秀, 漁 恵子, 平田 健一
    (一社)日本成人先天性心疾患学会, 2015年01月, 日本成人先天性心疾患学会雑誌, 4(1) (1), 154 - 154, 日本語

  • Mana Hiraishi, Hidekazu Tanaka, Yoshiki Motoji, Takuma Sawa, Takayuki Tsuji, Tatsuya Miyoshi, Junichi Imanishi, Akihiro Kaneko, Kensuke Matsumoto, Toshiro Shinke, Ken-ichi Hirata
    Worsening of mitral regurgitation (MR) is sometimes observed after closure of an atrial septal defect (ASD). However, since the mechanism of this deterioration remains unclear, the aim of our study was to investigate the effect of left (LV) and right ventricular (RV) geometry on MR after transcatheter closure of ASD.We studied 27 patients with ASD who underwent transcatheter closure. Echocardiography was performed before and 6 ± 2 months after the procedure. In addition to conventional echocardiographic parameters, full volume data of the whole LV and RV heart was obtained with 3-dimensional echocardiography. MR was quantified by measuring the width of the vena contracta, and was graded as mild (< 3.0 mm), moderate (3.0 to 6.9 mm), or severe (≥ 7.0 mm).Ten patients (37%) were classified as having worsening MR and the remaining 17 (63%) as not having worsening MR. The two groups showed similar baseline characteristics, except for patients with worsening MR being more likely to be older (P = 0.009) and having a larger left-to-right shunt of pulmonary and systemic blood flow ratio (P = 0.02). It is noteworthy that the horizontal-to-vertical ratio of basal-RV at end-systole for patients with worsening MR was significantly smaller than that for patients without worsening MR (1.0 ± 0.2 versus 1.4 ± 0.2, P < 0.0001). Furthermore, multivariate analysis showed that the horizontal-to-vertical ratio of basal-RV at end-systole was the independent predictor of worsening MR during follow-up (P < 0.001).RV geometry may affect MR after closure of ASD. The pre-operative horizontal-to-vertical ratio of basal-RV is considered useful for predicting worsening of MR after closure of ASD.
    2015年, International heart journal, 56(5) (5), 516 - 21, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Tatsuya Miyoshi, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Yuko Fukuda, Toshiro Shinke, Ken-ichi Hirata
    Early diastolic mitral inflow and annulus velocities ratio (E/e') is the parameter used to estimate left ventricular (LV) filling pressure, but their use for patients with reduced ejection fraction (EF) (<50 %) is controversial. LV endocardial area change rate with 3-dimensional (3-D) speckle-tracking can be used to evaluate the entire LV diastolic function, we tested the hypothesis that the early diastolic area change rate (E-ACR) represents LV relaxation, and E and E-ACR ratio (E/E-ACR) can accurately predict LV filling pressure in patients with reduced and preserved EF (≥50 %). We studied 125 patients with EF of 40 ± 17 %. E-ACR of all patients was measured using the global area change rate, and LV relaxation time constant (τ, n = 53) and pulmonary capillary wedge pressure (PCWP, n = 125) were measured by cardiac catheterization. E-ACR significantly correlated with τ (r = -0.60, p < 0.001). In the retrospective group (n = 101), E/E-ACR correlated with PCWP for patients with reduced EF as well as those with preserved EF (n = 79 and 22, r = 0.62 and 0.81, both p < 0.001). In overall patients, E/E-ACR ≥94 cm was a better predictor of elevated mean PCWP (>12 mmHg) (sensitivity: 69 %, specificity: 87 %, areas under the curves = 0.82; p < 0.001) and was a more accurate predictor than E/e' (p = 0.001) for the retrospective group. For the validation group (n = 24), E/E-ACR ≥94 cm was similarly predictive for elevated mean PCWP (sensitivity: 60 %, specificity: 100 %, positive predictive value: 100 %, negative predictive value: 78 %). In conclusions, global E-ACR by 3-D speckle-tracking proved to be dependent on LV relaxation. Moreover, E/E-ACR was found to be a powerful predictor of LV filling pressure regardless of EF.
    2014年12月, The international journal of cardiovascular imaging, 30(8) (8), 1473 - 81, 英語, 国際誌
    [査読有り]

  • Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Tatsuya Miyoshi, Yoshiki Motoji, Junichi Imanishi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Ken-Ichi Hirata
    The use of β-blockers has improved the prognosis of dilated cardiomyopathy (DCM) and the appearance of left ventricular (LV) reverse remodeling is generally thought to result in a more favorable prognosis. While there are many prognostic predictors, not all of them are applicable to individual patients. Global circumferential strain (GCS) was identified as a powerful prognostic marker, which appears to be a better parameter than LV global function for patients with depressed left ventricular (LV) ejection fraction. Seventy consecutive patients with newly-diagnosed DCM with LVEF of 28 ± 8 % (all <45 %) were retrospectively recruited. Either carvedilol or bisoprolol was titrated to a dose that was tolerable for each of the patients. GCS was determined as the peak global speckle-tracking circumferential strain from the mid-LV short-axis view. LV reverse remodeling was defined as an absolute increase in LVEF of at least 10 % during 8.1 ± 5.2-month follow-up after initiation of the maintenance dose of β-blockers. GCS ≥ 5.4 % was identified as the best predictor of LV reverse remodeling with 91 % sensitivity and 82 % specificity, and an area under the curve of 0.896 (p < 0.0001). An important finding of multivariate logistic regression analysis was that GCS was the best independent predictor of LV reverse remodeling (OR 7.692; 95 % CI 2.292-25.82; p = 0.001). It should be noted that only 1.3 ± 0.4 min per patient was needed to analyze GCS. In conclusions, GCS could result in further improvements in predicting LV reverse remodeling after β-blocker administration, and have clinical implications for better management in daily clinical practice.
    2014年10月, The international journal of cardiovascular imaging, 30(7) (7), 1279 - 87, 英語, 国際誌
    [査読有り]

  • Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Takuma Sawa, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Toshiro Shinke, Noriaki Emoto, Ken-Ichi Hirata
    We tested the hypothesis that the addition of right atrial (RA) remodeling to right ventricular (RV) function enhances the capability of the latter to predict long-term outcome for pulmonary hypertension (PH) patients. We studied 82 PH patients, all of whom underwent echocardiography and right heart catheterization. RV function was calculated by averaging the three regional peak speckle-tracking longitudinal strains from RV free wall (RV-free). RA remodeling was assessed as the RA area traced planimetrically at end-systole. Pre-defined cutoffs for RV dysfunction and RA remodeling were RV-free ≤19.4 % and RA area of >18 cm(2), respectively. Long-term unfavorable outcome events were tracked for 2.0 years. RA area correlated with mean RA pressure (r = 0.62, p < 0.001), as well as with tricuspid E/E' (r = 0.38, p = 0.001). Moreover, RA area in patients with RV restrictive filling was significantly larger than that in patients with others (all p < 0.05). Kaplan-Meier analysis revealed that patients with RV-free ≤19.4 % had worse long-term outcomes than those with RV-free >19.4 % (log-rank p = 0.01), as did patients with RA area >18 cm(2) compared with those with RA area ≤18 cm(2) (log-rank p < 0.05). For sequential Cox models, a model based on hemodynamic parameters of RV performance (χ2 = 3.11) was improved by addition of brain natriuretic peptide, World Health Organization functional class (χ2 = 9.24; p < 0.05), and RV-free (χ2 = 17.11; p = 0.005), and further improved by addition of RA area (χ2 = 21.36, p < 0.05). In conclusion, the combined assessment of RV function and RA area results in more accurate prediction of long-term outcome, and may well have clinical implications for better management of PH patients.
    2014年10月, The international journal of cardiovascular imaging, 30(7) (7), 1269 - 77, 英語, 国際誌
    [査読有り]

  • Tatsuya Miyoshi, Hidekazu Tanaka, Akihiro Kaneko, Kazuhiro Tatsumi, Kensuke Matsumoto, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: Anthracycline chemotherapy generates progressive dose-dependent left ventricular (LV) dysfunction associated with a poor prognosis. Early detection of minor LV myocardial dysfunction caused by the cardiotoxicity of anthracycline is thus important for predicting global LV dysfunction. METHODS: Fifty patients with preserved ejection fraction (all ≥55%) after receiving anthracycline chemotherapy were recruited for this study. Two-dimensional speckle tracking was used to assess global radial and circumferential strains from mid-LV short-axis views and global longitudinal strain from the apical four- and two-chamber view as peak global strain curves. Three-dimensional (3D) radial, circumferential, and longitudinal myocardial function was quantified as a peak global strain curve using 3D speckle tracking from all 16 LV segments. 3D speckle tracking imaging was used to evaluate LV endocardial area change ratio (area strain) quantified as peak global area strain curve (3D-GAS) to determine LV endocardial function. Twenty age-, gender-, and EF-matched normal volunteers were studied for comparisons. RESULTS: Only 3D-GAS and peak 3D global circumferential strains of the anthracycline group were significantly worse than those of the control group (-43.3 ± 3.1 vs. -45.8 ± 4.3% and -31.6 ± 3.5% vs. -34.4 ± 4.2%, respectively; P = 0.008, P = 0.004) even though global LV systolic and diastolic functions were similar. 3D-GAS correlated significantly with the cumulative doxorubicin dose (r = 0.316, P = 0.026). It was noteworthy that multivariate analysis showed only 3D-GAS (β = 0.323, P = 0.025) was independently associated with cumulative doxorubicin dose. CONCLUSIONS: Three-dimensional speckle tracking area strain was found useful for early detection of minor LV endocardial dysfunction associated with the use of anthracycline, and may thus prove to be clinically useful for predicting global LV dysfunction.
    2014年08月, Echocardiography (Mount Kisco, N.Y.), 31(7) (7), 848 - 57, 英語, 国際誌
    [査読有り]

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Tetsuari Onishi, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    The objective of this study was to test the hypothesis that combining assessment of baseline radial strain dyssynchrony index (SDI), that expressed both left ventricular (LV) dyssynchrony and residual myocardial contractility, and of acute changes in this index can yield more accurate prediction of mid-term responders and long-term outcome after cardiac resynchronization therapy (CRT). Radial SDI for 75 CRT patients was calculated as the average difference between peak and end-systolic speckle tracking strain from 6 segments of the mid-LV short-axis view before and 8 ± 2 days after CRT. Mid-term responder was defined as ≥ 15% decrease in LV end-systolic volume 6 ± 2 months after CRT. Long-term outcome was tracked over 5 years. Baseline radial SDI ≥ 6.5% is considered predictive of responder and favorable outcome, as previously reported. Acute reduction in radial SDI ≥ 1.5% was found to be the best predictor of mid-term responders with CRT. Furthermore, patients with acute reductions in radial SDI ≥1.5% were associated with a significantly more favorable long-term outcome after CRT than those with radial SDI <1.5% (log rank P < 0.001). An important findings were that baseline radial SDI ≥6.5% and acute reductions in radial SDI ≥ 1.5% in 42 patients were associated with the highest event-free survival rate of 92%, whereas, 21 patients corresponding values of <6.5% and <1.5% were associated with low event-free survival rate of 46% (log rank P < 0.001). Combined assessment of baseline radial SDI and its acute reduction after CRT may have clinical implications for predicting responders and thus patients' care.
    2014年04月, Echocardiography (Mount Kisco, N.Y.), 31(4) (4), 464 - 73, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Junichi Imanishi, Kazuhiro Tatsumi, Yoshiki Motoji, Tatsuya Miyoshi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: The importance of left atrial (LA) functional reserve in patients with depressed left ventricular function remains unclear. Thus, the aim of this study was to test the hypothesis that diminished augmentation of LA function during dobutamine stress might be associated with cardiovascular events in patients with dilated cardiomyopathy. METHODS: Eighty-four patients with dilated cardiomyopathy with a mean ejection fraction of 34 ± 9% were retrospectively recruited, and LA strain was determined as the averaged global speckle-tracking longitudinal strain from apical four-chamber and two-chamber views during dobutamine stress (20 μg/kg/min). The systolic component of LA strain was considered to reflect reservoir function, whereas the passive and active emptying components were considered to reflect passive and active emptying function, respectively. Event-free survival was tracked for 17 months. RESULTS: Multivariate Cox proportional-hazards analysis identified LA volume index (hazard ratio [HR], 1.060; P < .001) and β-blocker use (HR, 0.048; P < .05) as the independent variables associated with cardiovascular events among the baseline parameters and changes in systolic LA strain (HR, 0.971; P = .02), in passive emptying LA strain (HR, 0.942; P < .001), and in left ventricular early diastolic strain rate (HR, 0.986; P = .03) under dobutamine as the variables among the functional reserve parameters. In sequential Cox models, a model based on clinical variables (χ(2) = 9.3) was improved by conventional echocardiographic parameters (χ(2) = 19.2, P = .012) and LA strain parameters at rest (χ(2) = 40.1, P = .005) and further improved by the addition of changes in LA strain parameters under dobutamine (χ(2) = 61.6, P < .001). CONCLUSIONS: The assessment of LA reservoir and passive emptying function during dobutamine stress provides important incremental prognostic value in patients with dilated cardiomyopathy.
    2014年04月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 27(4) (4), 430 - 9, 英語, 国際誌
    [査読有り]

  • Junichi Imanishi, Hidekazu Tanaka, Takuma Sawa, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Ken-ichi Hirata
    Postoperative atrial fibrillation (POAF) is associated with increased risk of embolic events and heart failure, but its associated factors remains unknown. Left atrial (LA) subclinical mechanical dysfunction caused by the acute stress of surgery may be clinically manifested as POAF. The purpose of our study was therefore to test the hypothesis that preoperative LA subclinical myocardial dysfunction is a potential predictor of development of POAF in patients with aortic stenosis (AS). We studied 27 patients with severe AS undergoing aortic valve replacement (AVR) with left ventricular (LV) ejection fraction of 63 ± 11 %. All patients were in sinus rhythm and had no history of atrial fibrillation (AF). LA reservoir (SR-LAs), conduit (SR-LAe), and booster-pump (SR-LAa) functions were determined as the averaged global LA speckle-tracking longitudinal strain rates from apical four- and two-chamber views. POAF, defined as any episode of AF within 30-day after AVR, was observed in 15 patients (56 %). There were no differences in clinical characteristics, LA and LV volumes, and global LV function between patients with and without POAF. Multivariate logistic regression analysis identified SR-LAa as the only independent predictor of POAF. Furthermore, SR-LAa >0.79 s(-1) predicted POAF with 60 % sensitivity, 92 % specificity, and area under the curve of 0.828 (p < 0.0001). Of the 15 patients with POAF, one developed paroxysmal AF during long-term follow-up. In conclusions, SR-LAa helped to detect subtle LA booster-pump dysfunction and was associated with new-onset POAF in patients with severe AS. These findings may be useful for risk stratification and management of such patients.
    2014年02月, The international journal of cardiovascular imaging, 30(2) (2), 295 - 304, 英語, 国際誌
    [査読有り]

  • Easy-to-use comprehensive speckle-tracking approach for cardiac resynchronization therapy.
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to the patient's response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, are also influential. METHODS AND RESULTS: We studied 132 patients undergoing CRT. LV dyssynchrony was determined by anteroseptal-to-posterior wall delay on the mid-LV short-axis view using 2-dimensional speckle-tracking radial strain (≥130 ms as significant). Global circumferential strain (GCS), considered as a parameter of LV intrinsic myocardial function, was also determined as the peak GCS from the same view. Long-term follow-up was tracked over 40 months. Kaplan-Meier analysis indicated that patients with GCS >3.9% experienced fewer cardiovascular events overall (log-rank P=0.034). Similarly, patients with GCS >3.9% and ≥6.6% experienced fewer cardiovascular events than those with GCS ≤3.9% and <6.6% among patients with and without LV dyssynchrony (log-rank P=0.025 and P=0.029, respectively). An important finding from multivariate Cox proportional hazards analysis was that LV dyssynchrony and GCS were independently associated with cardiovascular events. Of note, only 2±1 min per patient were needed to analyze both LV dyssynchrony and GCS from the same routine mid-LV short-axis view. CONCLUSIONS: This easy-to-use combined assessment of LV dyssynchrony and myocardial function using speckle-tracking strain from the same mid-LV short-axis view may well have clinical implications for CRT.
    2014年, Circulation journal : official journal of the Japanese Circulation Society, 78(9) (9), 2250 - 8, 英語, 国内誌
    [査読有り]

  • Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    A case was 53-year-old female with dilated-phase hypertrophic cardiomyopathy. She was classified as New York Heart Association functional class III heart failure despite receiving optimal medical therapy. The electrocardiogram taken showed intraventricular conduction delay with a QRS width of 194 msec. The left ventricular (LV) end-diastolic and systolic volumes, and ejection fraction (EF) were 101 mL, 68 mL, and 32%, respectively. The patient showed no significant mechanical LV dyssynchrony as evidenced by two-dimensional (2D) speckle tracking radial strain, which is defined as the time difference between anterior-septum and posterior wall, of 105 msec (<130 msec). Three-dimensional (3D) speckle tracking radial strain was performed for more detailed LV mechanical dyssynchrony analysis. An especially important finding for 3D speckle tracking radial strain analysis was that the average time-to-peak strain of 5 septum segments at 3 different LV levels (basal-anterior-septum, basal-septum, mid-anterior-septum, mid-septum, apical-septum) was significantly shorter than that of 5 posterolateral segments at 3 different LV levels (basal-posterior, basal-lateral, mid-posterior, mid-lateral, apical-lateral). This time difference between septum and posterolateral wall was 216 msec (204 msec vs. 420 msec), which was considered to indicate significant LV mechanical dyssynchrony (≥130 msec). 12 months after cardiac resynchronization therapy (CRT), EF had improved to 47%, while end-systolic and diastolic volumes had decreased to 88 mL and 47 mL, respectively, so that the patient was classified as a responder. In conclusions, a newly developed 3D speckle tracking strain can provide a comprehensive evaluation of "true" LV mechanical dyssynchrony from pyramidal 3D data sets acquired in the same beat, thus yielding more accurate information than previously possible with the 2D speckle tracking system.
    2013年10月, Echocardiography (Mount Kisco, N.Y.), 30(9) (9), E292-5, 英語, 国際誌
    [査読有り]

  • Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Keiko Ryo, Kensuke Matsumoto, Yutaka Okita, Hiroya Kawai, Ken-Ichi Hirata
    AIMS: It remains difficult to detect subtle left ventricular (LV) myocardial dysfunction in chronic aortic regurgitation (AR) patients with the preserved ejection fraction (EF). METHODS AND RESULTS: We studied 36 chronic severe AR patients undergoing surgical correction with the EF of 58 ± 6% (all ≥ 50%). Echocardiography was performed before and 12 ± 8 months after surgical correction. We used two-dimensional speckle-tracking strain imaging to evaluate global radial strain in the inner-half (GRSinner), outer-half (GRSouter), and total (GRStotal) layer from the mid-LV short-axis view. We also evaluated the transmural strain profile in the LV posterior wall by using myocardial tissue Doppler radial strain, and the location of peak strain was determined as the percentage of the distance from the endocardium to the epicardium accounted for by the wall thickness. Fifteen EF-matched normal volunteers were studied for comparison. GRSinner for AR patients was significantly smaller than that for controls (28.9 ± 12.9 vs. 37.1 ± 9.1%, P = 0.032), and the location of peak strain had significantly shifted to the epicardial side compared with that in controls (27.1 ± 14.0-13.2 ± 4.8%, P = 0.001). In contrast, GRStotal and GRSouter were similar for the two groups. After surgical correction, EF increased from 58 ± 6 to 62 ± 7% (P = 0.018), GRSinner from 27.8 ± 12.5 to 37.7 ± 14.6% (P < 0.0001), and the location of peak strain significantly shifted to the endocardial side (26.9 ± 13.9-19.1 ± 11.9%, P = 0.028). However, GRStotal and GRSouter did not change. CONCLUSION: The LV endocardium side, impaired in chronic AR patients with the preserved EF, improved after surgical correction. Our observations may prove useful for evaluating subtle early changes in such patients.
    2013年04月, European heart journal cardiovascular Imaging, 14(4) (4), 339 - 46, 英語, 国際誌
    [査読有り]

  • Tetsushi Yamamoto, Hidekazu Tanaka, Kensuke Matsumoto, Tomoko Lee, Hiroyuki Awano, Mariko Yagi, Takamitsu Imanishi, Nobuhide Hayashi, Yasuhiro Takeshima, Hiroya Kawai, Seiji Kawano, Ken-ichi Hirata
    Myocardial damage in Duchenne muscular dystrophy (DMD) has lethal outcomes, making early detection of myocardial changes in patients with DMD vital, because early treatment can help prevent the development of myocardial fibrosis. The aim of the present study was, therefore, to test the hypothesis that transmural strain profile (TMSP) analysis can predict future left ventricular (LV) dysfunction in patients with DMD with preserved ejection fraction. We studied 82 consecutive patients with DMD without LV wall motion abnormality, with an ejection fraction of 60 ± 5% (all ≥55%) and age 11 ± 3 years. Echocardiography was performed at baseline and 1 year of follow-up. TMSP in the posterior wall was evaluated from the mid-LV short-axis view. A normal TMSP pattern (1 peak in the endocardium, group 1) was seen in 44 patients, and TMSP with a notch (2 peaks in the endocardium, group 2) in the remaining 38 (46%). Wall motion abnormality in the posterior wall was observed in 16 patients (42%) in group 2 at 1 year of follow-up but in none of the patients in group 1 (42% vs 0%; p <0.001). Importantly, multivariate analysis showed that only TMSP with a notch (odds ratios 1.524, p <0.001) was an independent determinant of the presence of LV posterior wall motion abnormality at 1 year of follow-up. In conclusion, subclinical LV dysfunction can be detected by evaluation of TMSP in patients with DMD who do not have wall motion abnormalities by conventional echocardiography. TMSP with a notch proved effective for evaluating subtle early changes in patients with DMD and might be useful for predicting LV dysfunction.
    2013年03月, The American journal of cardiology, 111(6) (6), 902 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Takayuki Tsuji, Hidekazu Tanaka, Kensuke Matsumoto, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ich Hirata
    Since cardiac sarcoidosis (CS) leads to substantial morbidity and sudden death, early diagnosis and appropriate management are crucial for patients with CS. Echocardiography used to be considered a useful diagnostic tool for patients with CS, but CS may clinically present as dilated cardiomyopathy (DCM). Our objective was to investigate whether a novel three-dimensional (3-D) speckle-tracking strain can identify patients with CS more accurately. We studied 23 CS patients with an ejection fraction (EF) of 46 ± 10 %, and 16 EF-matched patients with DCM (EF 45 ± 11 %). Global radial (GRS), circumferential (GCS) and longitudinal (GLS) strain was assessed using 3-D speckle-tracking system. GRS of patients with CS was significantly lower than that of patients with DCM (18.5 ± 8.4 vs. 28.5 ± 8.3 %, p < 0.01), but GCS and GLS in patients with CS and DCM were similar. GRS ≦ 21.1 could differentiate CS from DCM with a sensitivity of 70 %, specificity of 88 % and area under the curve of 0.79. An additional noteworthy findings was that, patients with CS showed more negative radial strain curves than did those with DCM (1.7 ± 2.3 vs. 0.1 ± 0.5, p < 0.01). In conclusion, 3-D speckle-tracking radial strain shows good potential to distinguish CS from DCM. Our observations can thus be expected to have clinical implications for management of CS patients.
    2013年02月, The international journal of cardiovascular imaging, 29(2) (2), 317 - 24, 英語, 国際誌
    [査読有り]

  • Dynamic left ventricular dyssynchrony assessed on 3-dimensional speckle-tracking area strain during dobutamine stress has a negative impact on cardiovascular events in patients with idiopathic dilated cardiomyopathy.
    Kensuke Matsumoto, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: Left ventricular (LV) dyssynchrony is not a stable phenomenon, but rather, changes dynamically. Given that the prognostic impact of dynamic dyssynchrony has not yet been elucidated, the objective was to investigate the clinical impact of dynamic dyssynchrony on patients with dilated cardiomyopathy (DCM). METHODS AND RESULTS: Seventy DCM patients with ejection fraction 32±9% were retrospectively recruited, and 3-dimensional speckle-tracking area strain was used to measure both contractile reserve and changes in dyssynchrony during dobutamine stress. The standard deviation of time-to-peak area strain was adopted as the systolic dyssynchrony index. Event-free survival was then tracked over a 13-month period. A ≥7.55% increase in systolic dyssynchrony index during dobutamine stress (Δsystolic dyssynchrony index) was the best predictor of cardiovascular events with 77% sensitivity and 88% specificity. Multivariate Cox analysis indicated that not only the absence of contractile reserve (Δglobal area strain ≤21.1%: hazard ratio [HR], 15.29; P=0.01), but the presence of dynamic dyssynchrony (ΔLV dyssynchrony ≥7.55%: HR: 7.591; P=0.003) was an independent predictor of cardiovascular events. Importantly, absence of dynamic dyssynchrony and presence of contractile reserve were associated with the most favorable outcome (98%), whereas the reverse condition was associated with the worst outcome (20%, P<0.001). CONCLUSIONS: Dynamic dyssynchrony is a potential predictor of cardiovascular events in patients with DCM, while assessment of dynamic dyssynchrony in combination with contractile reserve may further improve prognostic risk stratification.
    2013年, Circulation journal : official journal of the Japanese Circulation Society, 77(7) (7), 1750 - 9, 英語, 国内誌
    [査読有り]

  • Aortic and mitral regurgitation associated with Behçet's disease.
    Takuma Sawa, Hidekazu Tanaka, Kensuke Matsumoto, Ken-Ichi Hirata
    2013年, Internal medicine (Tokyo, Japan), 52(21) (21), 2473 - 2473, 英語, 国内誌
    [査読有り]

  • Junichi Imanishi, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-Ichi Hirata
    Although left ventricular (LV) mechanical dyssynchrony can predict the response to cardiac resynchronization therapy (CRT), the presence of baseline LV dyssynchrony might not be the only determinant of the response to CRT. The objectives of the present study were to test the hypothesis that a combined assessment of baseline LV dyssynchrony and its acute improvement can produce a more accurate prediction of the long-term outcomes after CRT. We studied 121 patients with heart failure undergoing CRT. LV dyssynchrony was determined by measuring the anteroseptal-to-posterior wall time delay using the speckle-tracking radial strain (≥130 ms was predefined as significant) and was assessed at baseline and 7 ± 3 days after CRT. Long-term unfavorable outcome events were tracked for 5 years. Acute improvement in LV dyssynchrony of ≥33% was predictive of the long-term outcome with an area under the curve of 0.67 (p = 0.0024). Using this cutoff value, the Kaplan-Meier curve showed that patients with acute improvement in LV dyssynchrony experienced fewer cardiovascular events than those without (log-rank p = 0.0002). The event-free survival of patients whose baseline LV dyssynchrony was ≥130 ms and whose acute improvement in LV dyssynchrony was ≥33% was greater than that of the patients with baseline LV dyssynchrony of ≥130 ms but with acute improvement in LV dyssynchrony of <33% (88% vs 65%, p = 0.012). In conclusion, the combined assessment of baseline LV dyssynchrony and its acute improvement after CRT produced a more accurate prediction of long-term outcomes after CRT.
    2012年12月, The American journal of cardiology, 110(12) (12), 1814 - 9, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: It has been suggested that the assessment of left ventricular contractile reserve during dobutamine infusion can improve prognostic evaluation for patients with idiopathic dilated cardiomyopathy (DCM). However, the assessment of contractile reserve is often subjective, while three-dimensional (3D) speckle-tracking can quantify three different components of strain simultaneously from all 16 left ventricular segments. The purpose of this study was to investigate the capability of multidirectional deformational indices assessed by 3D speckle-tracking strain to predict cardiac events in patients with DCM. Whether such assessment under dobutamine infusion can enhance this method's predictive capability was also evaluated by comparison with two-dimensional (2D) speckle-tracking. METHODS: Sixty-five patients with DCM with a mean ejection fraction of 34 ± 8% (all <45%) were prospectively recruited, and both 3D and 2D speckle-tracking echocardiography was used to measure global circumferential strain (GCS), radial strain, and longitudinal strain at baseline and during dobutamine infusion (20 μg/kg/min). Event-free survival was then tracked over 12 months. RESULTS: Among all indices of contractile reserve, increase in 3D GCS under dobutamine infusion ≤ 2.71% best predicted cardiovascular events, with 83% sensitivity, 80% specificity, and an area under the curve of 0.874 (P < .001). Furthermore, the area under the curve for increase in 3D GCS was significantly larger than that for both resting 3D GCS and increase in 2D GCS (P < .05 for both). On multivariate Cox analysis, increase in 3D GCS was the only independent predictor of cardiovascular events (hazard ratio, 0.635; P < .001). CONCLUSIONS: Assessment of contractile reserve using 3D GCS has the potential to predict cardiovascular events in patients with DCM and may thus have clinical implications for the management of such patients.
    2012年12月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 25(12) (12), 1299 - 308, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Hiroya Kawai, Ken-Ichi Hirata
    BACKGROUND: Regional heterogeneity of left ventricular (LV) contraction, known as dyssynergy, in idiopathic dilated cardiomyopathy (IDC) patients has been previously reported, but no comprehensive analysis of this abnormality has been made. The purpose of this study was to test the hypothesis that regional heterogeneity of systolic dysfunction is associated with LV dyssynchrony in IDC patients with a narrow QRS complex using novel three-dimensional (3D) speckle-tracking strain. METHODS: We studied 54 consecutive IDC patients with ejection fraction (EF) of 34 ± 12% and QRS duration of 102 ± 13 msec (all <120 msec), and 30 age-matched normal controls. The 3D speckle-tracking LV dyssynchrony (LV dyssynchrony index) was quantified from all 16 LV sites to determine the standard deviation (SD) of time-to-peak strain. Similarly, regional heterogeneity of LV systolic function (LV dyssynergy index) was quantified from all 16 LV sites to establish the SD of peak 3D speckle-tracking strain. RESULTS: The LV dyssynergy and dyssynchrony indices of IDC patients were significantly larger than those of normal controls. Furthermore, IDC patients showed significantly higher Z-scores for septum and inferior regions than for the free wall (3.34 ± 1.21 vs. 1.69 ± 1.06 and 2.79 ± 1.30 vs. 1.69 ± 1.06, respectively, P < 0.001). An important findings of multivariable analysis was that the LV dyssynergy index (β = 0.69, P < 0.001) and LVEF (β = -0.34, P = 0.001) were independent determinants of the LV dyssynchrony index. CONCLUSION: 3D speckle-tracking strain revealed that the myocardial systolic dysfunction of IDC patients with a narrow QRS complex has a marked heterogeneous regional distribution. This regional heterogeneity as well as systolic dysfunction is thought to lead to LV dyssynchrony.
    2012年11月, Echocardiography (Mount Kisco, N.Y.), 29(10) (10), 1201 - 10, 英語, 国際誌
    [査読有り]

  • Hidekazu Tanaka, Kensuke Matsumoto, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    AIMS: Although right ventricular (RV) pacing has a detrimental effect on global left ventricular (LV) function even in some patients with preserved ejection fraction (EF), its mechanism remains unclear. METHODS AND RESULTS: We studied 116 subjects; 56 patients with RV pacing and preserved EF (all ≥50%), 30 EF-matched controls, and 30 heart failure (HF) patients with RV pacing and reduced EF (all ≤35%). Radial, circumferential, and longitudinal dyssynchrony and function were quantified as standard deviations of the time-to-peak strain and global peak strain from all 16 LV segments using three-dimensional (3D) speckle-tracking strain. The degree of radial and circumferential dyssynchrony and function were similar for patients with RV pacing and preserved EF and controls. However, patients with RV pacing and preserved EF showed a greater longitudinal dyssynchrony of 46 ± 14 vs. 31 ± 9 ms (P < 0.01) and lower global longitudinal strain at 25 ± 4 vs. 34 ± 7% compared with controls (P < 0.001). Furthermore, longitudinal strain at the apical level was significantly lower than that at the mid- and basal level (20 ± 4 vs. 27 ± 5 and 26 ± 5%, P < 0.001), and longitudinal dyssynchrony at the apical level was significantly larger than at the mid- and basal level (44 ± 19 vs. 36 ± 20 and 32 ± 15 ms, P < 0.05) in patients with RV pacing and preserved EF. In contrast, HF patients with RV pacing and reduced EF showed greater radial, circumferential, and longitudinal dyssynchrony, and lower global radial, circumferential, and longitudinal strain than did controls (all P < 0.001). CONCLUSION: Three-dimensional speckle-tracking strain was found to be useful for evaluating early subtle changes associated with chronic RV pacing, and may thus play a clinical role in predicting future global LV dysfunction.
    2012年10月, European heart journal cardiovascular Imaging, 13(10) (10), 849 - 56, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Shota Yamana, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Kenji Sekiguchi, Fumi Kawakami, Hiroya Kawai, Ken-ichi Hirata
    2012年07月, CANADIAN JOURNAL OF CARDIOLOGY, 28(4) (4), 515, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Mariko Okada, Hidekazu Tanaka, Kensuke Matsumoto, Keiko Ryo, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: The aim of this study was to test the hypothesis that patients with reverse-remodeled dilated cardiomyopathy (DCM), whose ejection fractions (EFs) were normalized after optimal pharmacologic therapy, had subclinical myocardial dysfunction. METHODS: Thirty-two patients with reverse-remodeled DCM, defined as having an initial EF ≤ 35%, which then recovered to ≥50% after optimal pharmacologic therapy, and 11 normal controls with preserved EFs were retrospectively studied. Averaged peak systolic and early diastolic radial, circumferential, and longitudinal speckle-tracking strain rates were assessed from an 18-segment left ventricular model. Similarly, averaged peak systolic radial, circumferential, and longitudinal speckle-tracking strain was obtained. RESULTS: Peak systolic and early diastolic longitudinal strain rates, peak systolic and early diastolic circumferential strain rates, and peak circumferential and longitudinal strain in patients with reverse-remodeled DCM were significantly lower than those in normal controls, but peak systolic and early diastolic radial strain rates and peak radial strain in patients with reverse-remodeled DCM were similar to those in normal controls. Isometric handgrip stress testing showed a significant decrease in EF from 56 ± 5% to 51 ± 5% (P < .001). Of note, the increase of afterload resulting from isometric handgrip stress testing was associated with a decrease in peak systolic circumferential and longitudinal strain rates and peak circumferential strain in patients with reverse-remodeled DCM. CONCLUSIONS: The circumferential and longitudinal myocardial function of patients with reverse-remodeled DCM is lower compared with that of normal controls with preserved EFs. Furthermore, the increase in afterload was associated with the decrease in circumferential and longitudinal myocardial systolic function. These findings suggest that in treated patients with DCM with reverse remodeling, left ventricular mechanics may not be normal, even when EFs are normal.
    2012年07月, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 25(7) (7), 726 - 32, 英語, 国際誌
    [査読有り]

  • Hidekazu Tanaka, Kensuke Matsumoto, Hiroya Kawai, Ken-Ichi Hirata
    2012年06月, European heart journal cardiovascular Imaging, 13(6) (6), 531 - 531, 英語, 国際誌
    [査読有り]

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Tetsuari Onishi, Akihiro Yoshida, Hiroya Kawai, Ken-Ichi Hirata
    Strain dyssynchrony index (SDI), which was a marker of dyssynchrony and residual myocardial contractility, can predict left ventricular reverse remodeling short-term after cardiac resynchronization therapy (CRT). We investigated SDI-predicted long-term outcome after CRT in patients with heart failure (HF). We studied 74 patients with HF who underwent CRT. SDI was calculated as the average difference between peak and end-systolic strain from 6 segments for radial and circumferential SDIs and 18 segments for longitudinal SDI using 2-dimensional speckle-tracking strain. Based on our previous findings, the predefined cutoff for significant dyssynchrony and residual myocardial contractility was a radial SDI ≥6.5%, a circumferential SDI ≥3.2%, and a longitudinal SDI ≥3.6%. The predefined principal outcome variable was the combined end point of death or hospitalization owing to deteriorating HF. Long-term follow-up after CRT was tracked over 4 years. The primary end point of prespecified events occurred in 14 patients (19%). An association with a favorable long-term outcome after CRT was observed in patients with significant radial, circumferential, and longitudinal SDIs (p <0.001, <0.005, and 0.010 vs patients without significant SDIs, respectively). Furthermore, cardiovascular event-free rate after CRT in patients with positivity of 3 for the 3 SDIs was 100% better than that in patients with positivity of 1 (52%, p <0.005) or 0 (31%, p <0.001) for the 3 SDIs. In conclusion, SDIs can successfully predict long-term outcome after CRT in patients with HF. Moreover, the approach combining the 3 types of SDI leads to a more accurate prediction than the use of individual parameters. These findings may have clinical implications in patients with CRT.
    2012年04月, The American journal of cardiology, 109(8) (8), 1187 - 93, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Hiroya Kawai, Ken-Ichi Hirata
    The aim of this study was to use 3-dimensional (3D) speckle-tracking echocardiography to test the hypothesis that left ventricular (LV) dyssynchrony may negatively affect LV torsional mechanics in patients with idiopathic dilated cardiomyopathy (IDC) and that LV torsion may improve after cardiac resynchronization therapy. This study included 65 subjects; 20 with IDC with ejection fractions ≤35% and wide QRS complexes (≥120 ms), 20 with IDC with ejection fractions ≤35% and narrow QRS complexes (<120 ms), and 25 controls. LV dyssynchrony index was determined as the SD of time to peak 3D speckle-tracking radial strain and regional heterogeneity of LV rotation (rotational dispersion index) as the SD of 3D speckle-tracking time to peak rotation. All rotational indexes were significantly impaired in patients with IDC, while LV torsion in patients with IDC with wide QRS complexes was significantly smaller than that in patients with IDC with narrow QRS complexes and controls. Conversely, LV dyssynchrony index (127.3 ± 24.0 ms [p <0.01 vs controls and vs patients with narrow QRS complexes] vs 88.8 ± 22.5 ms [p <0.01 versus controls] vs 30.9 ± 10.0 ms) and rotational dispersion index (115.1 ± 27.5 ms [p <0.01 vs controls and vs patients with narrow QRS complexes] vs 96.0 ± 23.4 ms [p <0.01 versus controls] vs 45.0 ± 13.7 ms) were significantly higher in patients with IDC with wide QRS complexes. Multivariate analysis showed that the LV ejection fraction (β = 0.688, p <0.001) and rotational dispersion index (β = -0.249, p <0.01) were independent determinants of LV torsion. Moreover, LV torsion in patients with IDC with wide QRS complexes improved after cardiac resynchronization therapy (p <0.05), along with reductions in LV dyssynchrony and rotational dispersion indexes. In conclusion, these findings obtained with a novel 3D speckle-tracking system feature a novel aspect of LV torsional mechanics and demonstrate its association with LV dyssynchrony.
    2012年04月, The American journal of cardiology, 109(8) (8), 1197 - 205, 英語, 国際誌
    [査読有り]

  • Yoshiki Motoji, Hidekazu Tanaka, Tatsuya Miyoshi, Junichi Imanishi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-Ichi Hirata
    2012年03月, Journal of echocardiography, 10(1) (1), 35 - 7, 英語, 国内誌
    [査読有り]

  • Effect of left ventricular dyssynchrony on cardiac sympathetic activity in heart failure patients with wide QRS duration.
    Hidekazu Tanaka, Kazuhiro Tatsumi, Sei Fujiwara, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kensuke Matsumoto, Mayumi Shigeru, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: Dyssynchrony has various detrimental effects on cardiac function, but its effect on cardiac sympathetic activity is not fully understood. METHODS AND RESULTS: We studied 50 heart failure patients who underwent cardiac resynchronization therapy (CRT). Cardiac sympathetic activity was assessed by (123)I-metaiodobenzylguanidine ((123)I-MIBG) scintigraphy as the delayed heart-to-mediastinum ratio (H/M ratio). Echocardiography was performed before and 7 months after CRT, and response was defined as a ≥15% decrease in end-systolic volume. Dyssynchrony was determined by the time difference between the anteroseptal-to-posterior wall using speckle-tracking radial strain (≥130 ms predefined as significant). H/M ratio in patients with dyssynchrony was less than that in patients without dyssynchrony (1.62 ± 0.31 vs. 1.82 ± 0.36, P<0.05), even though ejection fraction was not significantly different (24 ± 6% vs. 25 ± 7%). Patients with dyssynchrony and H/M ratio ≥1.6 had a higher frequency of response to CRT (94%) and favorable long-term outcome over 3.0 years. In contrast, patients without dyssynchrony and H/M ratio <1.6 were more likely to show a lower frequency of response to CRT (0%) and unfavorable long-term outcome after CRT. CONCLUSIONS: Dyssynchrony is associated with cardiac sympathetic activity, and (123)I-MIBG scintigraphy may be valuable for predicting the response to CRT.
    2012年, Circulation journal : official journal of the Japanese Circulation Society, 76(2) (2), 382 - 9, 英語, 国内誌
    [査読有り]

  • Impact of left ventricular afterload on longitudinal dyssynchrony in patients with severe aortic stenosis and preserved ejection fraction.
    Kohei Yamawaki, Hidekazu Tanaka, Kensuke Matsumoto, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Kazuko Norisada, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Kenji Okada, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: The purpose of this study was to investigate whether patients with severe aortic stenosis (AS) and preserved ejection fraction (EF) have dyssynchrony and whether it improves after aortic valve replacement (AVR). METHODS AND RESULTS: We studied 30 consecutive patients with severe AS and preserved EF undergoing AVR. For baseline comparison, we studied 17 EF-matched patients with mild-to-moderate AS, and 18 EF-matched normal volunteers. Longitudinal dyssynchrony was determined as the standard deviation for time-to-peak speckle-tracking strain in apical 4- and 2-chamber views at the basal- and mid-levels. Radial and circumferential dyssynchrony was determined as the difference for time-to-peak strain between the anteroseptum and posterior wall from the mid-left ventricular (LV) short-axis view. Each of the myocardial functions was also evaluated by averaging each peak systolic strain. Longitudinal dyssynchrony and function in patients with severe AS was significantly worse than in the patients with mild-to-moderate AS and the controls (94 ± 46 vs. 66 ± 18 ms* and 52 ± 17 ms*, and 12.5 ± 3.7% vs. 16 ± 3.5%* and 18.7 ± 3.7%*, respectively, *P<0.05, vs. severe AS). In contrast, radial and circumferential dyssynchrony were similar for the 3 groups. Importantly, the dyssynchrony of patients with severe AS significantly improved after AVR from 94 ± 46 ms to 68 ± 22 ms (P<0.005). CONCLUSIONS: Significant longitudinal dyssynchrony was present in patients with severe AS and preserved EF, and it improved after AVR.
    2012年, Circulation journal : official journal of the Japanese Circulation Society, 76(3) (3), 744 - 51, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Tissue Doppler imaging-derived myocardial acceleration during isovolumetric contraction predicts pulmonary capillary wedge pressure in patients with reduced ejection fraction.
    Alaa Mabrouk Salem Omar, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: Tissue Doppler imaging-obtained isovolumetric myocardial acceleration (IVA) is load independent, reportedly predicts systolic functions, and correlates with exercise capacity in patients with reduced ejection fraction (EF). We hypothesized that IVA correlates with the pulmonary capillary wedge pressure (PCWP) in patients with reduced EF. METHODS AND RESULTS: Of 113 patients, correlations between PCWP and IVA were done for all patients, 48 patients with EF ≥55%, and 65 patients with EF <55%. Results were compared to the correlation between PCWP and other echocardiographic predictors. IVA correlated moderately with PCWP in all patients (r=0.54, P<0.0001) and was comparable to the E/A and E/e' ratios. In patients with EF ≥55%, IVA lost correlation and the only predictor was the E/e' ratio (r=0.08, 0.58, P=0.58, <0.0001). In patients with EF <55%, IVA was better than E/A and E/e' (r=0.72, 0.61, 0.51, P<0.0001), especially for atrial fibrillation or when E/e' fell between 8 and 15. Furthermore, IVA >1.60 m/s(2) can predict PCWP ≥15 mmHg, with a sensitivity of 95%, specificity of 73%, and an area under the curve of 0.867 (P<0.0001). CONCLUSIONS: IVA can predict PCWP in patients with reduced EF, and can be considered an alternative to the E/e' ratio for patients with atrial fibrillation or E/e' ratio between 8 and 15.
    2012年, Circulation journal : official journal of the Japanese Circulation Society, 76(6) (6), 1399 - 408, 英語, 国内誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Katsunori Okajima, Takatoshi Hayashi, Teishi Kajiya, Hiroya Kawai, Ken-Ichi Hirata
    The presence of functional mitral regurgitation (MR) is considered a significant risk factor for poor clinical prognosis in patients with idiopathic dilated cardiomyopathy (IDC). The objectives of this study were to test the hypothesis that not only global but also local left ventricular (LV) remodeling, including the position of the papillary muscles, may contribute to the development of MR in patients with IDC and wide QRS durations and can be reversed with cardiac resynchronization therapy (CRT). Eighty-four subjects were studied, 44 patients with IDC who underwent CRT and 40 age- and gender-matched controls. The position of the posteromedial papillary muscle was similar in the 2 groups, whereas the position of the anterolateral papillary muscle in patients with IDC was displaced more posteriorly than in controls. Multivariate analysis revealed that reduction in coaptation height (β = 0.44, p <0.001) and LV dyssynchrony by speckle-tracking radial strain (β = 0.303, p <0.01) were independent determinants of reduction in MR 5 ± 2 days after CRT; in contrast, restoration of the position of the posteriorly displaced anterolateral papillary muscle (β = 0.50, p <0.001) and the increase in sphericity index (β = 0.440, p <0.001) were identified as independent determinants of reduction in MR 6 ± 1 months after CRT. In conclusion, asymmetric local LV remodeling was observed at baseline, and asymmetric local LV reverse remodeling was observed at long-term follow-up after CRT in patients with IDC. Furthermore, different parameters contribute to the reduction in MR observed at short- and long-term follow-up after CRT.
    2011年11月, The American journal of cardiology, 108(9) (9), 1327 - 34, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Katsunori Okajima, Takatoshi Hayashi, Teishi Kajiya, Daisuke Sugiyama, Hiroya Kawai, Ken-ichi Hirata
    AIMS: Cardiac resynchronization therapy (CRT) can stop the vicious cycle resulting from dyssynchrony and generates left ventricular (LV) reverse remodelling. Our objective was to assess the time course and the relationship between improvement in LV dyssynchrony and reverse remodelling after CRT. METHODS AND RESULTS: Sixty-four consecutive patients were evaluated before, immediately after, and 3- and 6 months after CRT. We measured LV volumes, ejection fraction (EF), and sphericity index, and dyssynchrony was assessed using speckle-tracking radial strain. Response was defined as a >15% decrease in end-systolic volume (ESV) 6 months after CRT, and event-free survival was followed for 24 months. Responders and non-responders had similar baseline LV volumes and EF. During the first and the following 3 months after CRT, LV volumes gradually decreased (end-diastolic volume: 195±73 to 164±60* to 129±51 mL†, ESV: 141±70 to 110±47* to 82±40 mL†), and sphericity index and EF progressively increased (sphericity index: 1.52±0.20 to 1.75±0.31* to 1.94±0.34†, EF: 28±7 to 34±7* to 38±8%†, *†P<0.001) in responders. No such changes were observed in non-responders. Furthermore, dyssynchrony diminished progressively during the first and the following 3 months after CRT and patients with progressive resynchronization experienced fewer major cardiovascular events than those without (P<0.001). CONCLUSION: CRT can stop the vicious cycle of remodelling and dyssynchrony, and actually, turn it into the virtuous cycle of reverse remodelling and further resynchronization.
    2011年10月, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 12(10) (10), 782 - 9, 英語, 国際誌
    [査読有り]

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Kohei Yamawaki, Yuko Fukuda, Kazuko Norisada, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    The aim of this study was to assess whether heart failure (HF) patients with narrow QRS durations have mechanical left ventricular (LV) dyssynchrony compared to those with wide QRS durations and with normal subjects. The strain dyssynchrony index with 3-dimensional area tracking (ASDI) was used, which represents mechanical LV dyssynchrony and residual endomyocardial function from circumferential as well as longitudinal directions. The study included 79 subjects: 32 HF patients with ejection fractions ≤ 35% and narrow QRS durations (<120 ms) and 22 with ejection fractions ≤ 35% and wide QRS durations (≥ 120 ms), all candidates for cardiac resynchronization therapy, and 25 normal controls. ASDI was calculated as the average difference between peak and end-systolic area strain of LV endocardium obtained using 3-dimensional speckle-tracking imaging using 16 LV segments (≥ 3.8% predefined as significant). ASDI in HF patients with narrow QRS durations was lower than in their counterparts with wide QRS durations (2.5 ± 1.3% vs 4.2 ± 1.2%, p <0.001) but higher than in normal controls (2.5 ± 1.3% vs 0.73 ± 0.53%, p <0.001). Furthermore, the prevalence of significant ASDI in HF patients with narrow QRS durations was significantly higher than in normal controls (22% vs 0%, p = 0.01) but significantly lower than in HF patients with wide QRS durations (22% vs 59%, p <0.01). In conclusion, HF patients with narrow QRS durations have LV dyssynchrony. These observations suggest that the use of 3-dimensional speckle area tracking strain might be extended to HF patients with narrow QRS durations who are being considered as potential candidates for cardiac resynchronization therapy.
    2011年09月, The American journal of cardiology, 108(6) (6), 867 - 72, 英語, 国際誌
    [査読有り]

  • Kensuke Matsumoto, Hidekazu Tanaka, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Kohei Yamawaki, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    2011年09月, Echocardiography (Mount Kisco, N.Y.), 28(8) (8), E172-3, 英語, 国際誌
    [査読有り]

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Kohei Yamawaki, Alaa M S Omar, Yuko Fukuda, Kazuko Norisada, Kensuke Matsumoto, Tetsuari Onishi, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    BACKGROUND: We have previously reported strain dyssynchrony index assessed by two-dimensional speckle tracking strain, and a marker of both dyssynchrony and residual myocardial contractility, can predict response to cardiac resynchronization therapy (CRT). A newly developed three-dimensional (3-D) speckle tracking system can quantify endocardial area change ratio (area strain), which coupled with the factors of both longitudinal and circumferential strain, from all 16 standard left ventricular (LV) segments using complete 3-D pyramidal datasets. Our objective was to test the hypothesis that strain dyssynchrony index using area tracking (ASDI) can quantify dyssynchrony and predict response to CRT. METHODS: We studied 14 heart failure patients with ejection fraction of 27 ± 7% (all≤35%) and QRS duration of 172 ± 30 ms (all≥120 ms) who underwent CRT. Echocardiography was performed before and 6-month after CRT. ASDI was calculated as the average difference between peak and end-systolic area strain of LV endocardium obtained from 3-D speckle tracking imaging using 16 segments. Conventional dyssynchrony measures were assessed by interventricular mechanical delay, Yu Index, and two-dimensional radial dyssynchrony by speckle-tracking strain. Response was defined as a ≥15% decrease in LV end-systolic volume 6-month after CRT. RESULTS: ASDI ≥ 3.8% was the best predictor of response to CRT with a sensitivity of 78%, specificity of 100% and area under the curve (AUC) of 0.93 (p < 0.001). Two-dimensional radial dyssynchrony determined by speckle-tracking strain was also predictive of response to CRT with an AUC of 0.82 (p < 0.005). Interestingly, ASDI ≥ 3.8% was associated with the highest incidence of echocardiographic improvement after CRT with a response rate of 100% (7/7), and baseline ASDI correlated with reduction of LV end-systolic volume following CRT (r = 0.80, p < 0.001). CONCLUSIONS: ASDI can predict responders and LV reverse remodeling following CRT. This novel index using the 3-D speckle tracking system, which shows circumferential and longitudinal LV dyssynchrony and residual endocardial contractility, may thus have clinical significance for CRT patients.
    2011年04月, Cardiovascular ultrasound, 9, 11 - 11, 英語, 国際誌
    [査読有り]

  • Alaa Mabrouk Salem Omar, Hidekazu Tanaka, Tarek Khairy AbdelDayem, Ayman S Sadek, Halah Raslaan, Ashraf Al-Sherbiny, Kohei Yamawaki, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Tetsuari Onishi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    AIMS: The aim of this study was to test the hypothesis that, unlike calculation of the mitral valve area (MVA) with the pressure half-time method (PHT), the proximal isovelocity surface area method (PISA) is not affected by changes in net atrioventricular compliance (C(n)). METHODS AND RESULTS: We studied 51 patients with mitral stenosis (MS) from two centres. MVA was assessed with the PISA (MVA(PISA)), PHT (MVA(PHT)), and planimetry (MVA(PLN), serving as the gold standard) method. C(n) was calculated with a previously validated equation using 2D echocardiography. MVA(PISA) closely correlated with MVA(PLN) (r = 0.96, P < 0.0001), while MVA(PHT) and MVA(PLN) showed a weaker but still good correlation (r = 0.69, P < 0.0001). The correlation between MVA(PHT) and MVA(PLN) for patients with C(n) between 4 and 6 mL/mmHg (considered to be normal) was excellent (r = 0.93, P < 0.0001), but that for patients with C(n) of less than 4 or more than 6 mL/mmHg was not as good (r = 0.64, P < 0.0001). Importantly, a significant inverse correlation was detected between the percentage difference among MVA(PHT), MVA(PLN), and C(n) (r = -0.77, P < 0.0001), but the line of fit was nearly flat for the percentage difference among MVA(PISA), MVA(PLN), and C(n) (r = 0.1, P = 0.388). CONCLUSION: MVA calculated with both the PISA and PHT methods correlated well with MVA calculated with the planimetry method. However, the PISA rather than PHT is recommended for patients with MS and extreme C(n) values because PISA, unlike PHT, is not affected by changes in C(n).
    2011年04月, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 12(4) (4), 283 - 90, 英語, 国際誌
    [査読有り]

  • Kazuko Norisada, Hidekazu Tanaka, Tetsuari Onishi, Akihiro Kaneko, Takayuki Tsuji, Kohei Yamawaki, Keiko Ryo, Kazuhiro Tatsumi, Kensuke Matsumoto, Natsuko Miura, Jun Saegusa, Yukiko Morinaga, Shigeo Hara, Hiroya Kawai, Ken-Ichi Hirata
    A 63-year-old man was admitted to our hospital with a complaint of right lateroabdominal pain. He was diagnosed with metastatic colon cancer, and then developed multiple brain embolic infarctions 7 days after admission. Transesophageal echocardiography showed that mobile, echo-dense masses were attached to the anterior and posterior mitral valve leaflet. Furthermore, there was a thrombus in the left auricular appendage despite sinus rhythm. These findings led to a diagnosis of suspected infectious endocarditis with subsequent multiple brain infarctions. The patient's general condition worsened and he died 13 days after admission. An autopsy was performed, and, while poorly differentiated cancer was observed in multiple organs, no primary tumor could be identified. Histological analysis showed that the masses of the mitral valve consisted mainly of fibrin without bacteria or oncocytes. This patient was therefore diagnosed with nonbacterial thrombotic endocarditis associated with cancer of unknown origin complicated with thrombus in the left auricular appendage.
    2011年02月, Cardiovascular ultrasound, 9, 8 - 8, 英語, 国際誌
    [査読有り]

  • Hidekazu Tanaka, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Kohei Yamawaki, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    A 53-year-old man with depressed ejection fraction (EF) of 35% and QRS width of 88 ms at rest was admitted to our institution with a complaint of exertional chest discomfort and dyspnea. During treadmill exercise, left bundle-branch block (LBBB) with a QRS width of 152 ms occurred at a heart rate of 100 bpm. During LBBB, the patient showed significant mechanical dyssynchrony as evidenced by a two-dimensional speckle tracking radial strain of 260 ms (≥ 130 ms), defined as the time difference between anterior-septum and posterior wall. Five-month after carvedilol and candesartan administration, EF had improved to 49% and LBBB did not occur until a heart rate of 126 bpm was attained during treadmill exercise. It appears that pharmacological therapy may be useful for patients with heart failure and exercise-induced LBBB.
    2011年02月, Cardiovascular ultrasound, 9(1) (1), 4 - 4, 英語, 国際誌
    [査読有り]

  • Kazuhiro Tatsumi, Hidekazu Tanaka, Kouhei Yamawaki, Keiko Ryo, Alaa Mabrouk Salem Omar, Yuko Fukuda, Kazuko Norisada, Kensuke Matsumoto, Tetsuari Onishi, John Gorcsan 3rd, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    The strain delay index is reportedly a marker of dyssynchrony and residual myocardial contractility. The aim of this study was to test the hypothesis that a relatively simple version of the strain dyssynchrony index (SDI) can predict response to cardiac resynchronization therapy (CRT) and that combining assessment of radial, circumferential, and longitudinal SDI can further improve the prediction of responders. A total of 52 patients who underwent CRT were studied. The SDI was calculated as the average difference between peak and end-systolic strain from 6 segments for radial and circumferential SDI and 18 segments for longitudinal SDI. Conventional dyssynchrony measures were assessed by interventricular mechanical delay, the Yu index, and radial dyssynchrony by speckle tracking strain. Response was defined as a ≥15% decrease in end-systolic volume after 3 months. Of the individual parameters, radial SDI ≥6.5% was the best predictor of response to CRT, with sensitivity of 81%, specificity of 81%, and an area under the curve of 0.87 (p <0.001). Circumferential SDI ≥3.2% and longitudinal SDI ≥3.6% were also found to be predictive of response to CRT, with areas under the curve of 0.81 and 0.80, respectively (p <0.001). Moreover, radial, circumferential, and longitudinal SDI at baseline were correlated with reduction of end-systolic volume with CRT. In addition, the response rate in patients with 3 positive SDIs was 100%. In contrast, rates in patients with either 1 or no positive SDIs were 42% and 22%, respectively (p <0.005 and p <0.001 vs 3 positive SDIs). In conclusion, the SDI can successfully predict response to CRT, and the combined approach leads to more accurate prediction than using individual parameters.
    2011年02月, The American journal of cardiology, 107(3) (3), 439 - 46, 英語, 国際誌
    [査読有り]

  • Tetsushi Yamamoto, Tetsuari Onishi, Alaa Marbrouk Salem Omar, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Nobuhide Hayashi, Shouhiro Kinoshita, Seiji Kawano, Hiroya Kawai, Ken-Ichi Hirata, Shunichi Kumagai
    We report the extremely rare case of a 73-year-old asymptomatic patient who has an isolated true parachute mitral valve (PMV). In the echocardiographic examination, the parasternal long-axis view showed a single papillary muscle. The short-axis view revealed the presence of a symmetric mitral valve orifice with all chordae attaching to a large anterolateral papillary muscle. Because detailed examination did not reveal the presence of other complications, this patient was diagnosed as an isolated true PMV.
    2010年12月, Journal of echocardiography, 8(4) (4), 131 - 2, 英語, 国内誌
    [査読有り]

  • Tetsushi Yamamoto, Tetsuari Onishi, Akihiro Kaneko, Kensuke Matsumoto, Nobuhide Hayashi, Shohiro Kinoshita, Seiji Kawano, Hiroya Kawai, Ken-Ichi Hirata, Shunichi Kumagai
    2010年10月, Circulation, 122(16) (16), e488-90, 英語, 国際誌
    [査読有り]

  • Akira Shimane, Katsunori Okajima, Kazuo Mizutani, Masami Yoshida, Kimitake Imamura, Takatoshi Hayashi, Yasuyo Taniguchi, Shinichiro Yamada, Sachiyo Iwata, Masahiro Kumada, Yasue Tsukishiro, Kensuke Matsumoto, Yusuke Kurogane, Keiko Ryo, Takumi Inoue, Amane Kozuki, Masahiro Tashiro, Teishi Kajiya, Masato Yoshida, Kazuhiro Mizoguchi, Katsuhiro Yamanaka, Nobuhiko Mukohara, Kouhei Yamashiro
    2008年, Journal of Arrhythmia, 24(3) (3), 156 - 161, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Accuracy of nonstenotic coronary atherosclerosis assessment by multi-detector computed tomography.
    Tetsuya Hara, Shinichiro Yamada, Takatoshi Hayashi, Yoshihiro Ikeda, Kohei Yamashiro, Kazuo Mizutani, Sachiyo Iwata, Katsunori Okajima, Yasue Tsukishiro, Kensuke Matsumoto, Takafumi Akagami, Hiroyuki Kumagai, Mitsuo Kinugasa, Michihiko Inoue, Naoki Murai, Ichiro Izawa, Teishi Kajiya
    BACKGROUND: The ability to evaluate coronary stenosis using multi-detector computed tomography (MDCT) has been well discussed. In contrast, several studies demonstrated that the plaque burden measured by intravascular ultrasound (IVUS) has a relationship to the risk of cardiovascular events. the accuracy of MDCT was studied to determine plaque and vessel size compared with IVUS. METHODS AND RESULTS: Fifty-six proximal lesions (American College of Cardiology/American Heart Association classification: segment 1, 5, 6) from 33 patients were assessed using MDCT and IVUS. The plaque and vessel area were measured from the cross-sectional image using both MDCT and IVUS. Eight coronary artery lesions with motion artifacts and heavily calcified plaques were excluded from the analysis. The vessel and lumen size evaluated using MDCT were closely correlated with those evaluated by IVUS (R(2)=0.614, 0.750 respectively). Furthermore, there was a strong correlation between percentage plaque area assessed by MDCT and IVUS (R(2)=0.824). CONCLUSION: MDCT can noninvasively quantify coronary atherosclerotic plaque with good correlation compared with IVUS in patients with atherosclerosis.
    2007年06月, Circulation journal : official journal of the Japanese Circulation Society, 71(6) (6), 911 - 4, 英語, 国内誌
    [査読有り]

  • [Continuous venovenous hemofiltration (CVVH) therapy in patient with refractory heart failure].
    Kensuke Matsumoto, Takatoshi Hayashi
    2007年05月, Nihon rinsho. Japanese journal of clinical medicine, 65 Suppl 5, 255 - 8, 日本語, 国内誌
    [査読有り]

■ MISC
  • 極めて稀な高齢未修復ファロー四徴症の一例
    鈴木麻希子, 松本賢亮, 須藤麻貴子, 伊澤有, 三輪圭介, 藤田紘, 田中秀和, 平田健一
    2022年, 日本成人先天性心疾患学会雑誌(Web), 11(1) (1)

  • Yuko Yoshigai, Kensuke Matsumoto, Makiko Suto, Hidekazu Nakai, Ken-Ichi Hirata
    Oxford University Press, 2021年11月01日, European Heart Journal Cardiovascular Imaging, 22(11) (11), E157 - E158, 英語
    速報，短報，研究ノート等（学術雑誌）

  • Susumu Odajima, Kensuke Matsumoto, Eriko Hisamatsu, Kenji Okada, Ken-Ichi Hirata
    Oxford University Press, 2021年10月01日, European Heart Journal - Case Reports, 5(10) (10), 英語
    速報，短報，研究ノート等（学術雑誌）

  • Makiko Suto, Kensuke Matsumoto, Ken-Ichi Hirata
    Oxford University Press, 2021年09月21日, European Heart Journal, 42(36) (36), 3805, 英語
    速報，短報，研究ノート等（学術雑誌）

  • ファロー四徴症心内修復後患者における高度肺動脈弁逆流症をどのようにして同定するか
    須藤麻貴子, 松本賢亮, 鈴木麻希子, 伊澤有, 茂真由美, 田中秀和, 平田健一
    2021年, 超音波医学 Supplement, 48

  • 胸椎圧迫骨折を契機に体位変換性の呼吸困難感が増悪した1例
    東堂沙紀, 松本賢亮, 藤田紘, 三和圭介, 伊澤有, 小林成美, 平田健一
    2021年, 心臓, 53(10) (10)

  • IMPACT OF DIABETES MELLITUS ON LEFT VENTRICULAR LONGITUDINAL FUNCTION OF PATIENTS WITH NON-ISCHEMIC DILATED CARDIOMYOPATHY
    Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Kensuke Matsumoto, Ken-ichi Hirata
    2020年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 75(11) (11), 731 - 731, 英語
    研究発表ペーパー・要旨（国際会議）

  • Non-invasive assessment of preload reserve using the leg-positive pressure manoeuvre in patients with repaired tetralogy of Fallot
    M. Suto, K. Matsumoto, N. Shibata, S. Yokota, J. Mukai, E. Hisamatsu, H. Takada, F. Soga, K. Dokuni, Y. Hatani, K. Hatazawa, H. Matsuzoe, H. Tanaka, K. Hirata
    2018年08月, EUROPEAN HEART JOURNAL, 39, 314 - 314, 英語
    研究発表ペーパー・要旨（国際会議）

  • 心不全診療における心臓超音波検査の活かし方 下肢陽圧負荷装置を用いた心不全患者に対する前負荷予備能評価と、その臨床応用可能性
    松本 賢亮, 楠瀬 賢也, 山田 博胤, 平田 健一
    (公社)日本超音波医学会, 2018年04月, 超音波医学, 45(Suppl.) (Suppl.), S256 - S256, 日本語

  • Ventriculo-arterial Coupling as a Parameter for Detecting Heart Failure Symptoms in Patients With Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    Junichi Ooka, Hidekazu Tanaka, Kensuke Matsumoto, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Yasuhide Mochizuki, Ken-ichi Hirata
    2017年11月, CIRCULATION, 136, 英語
    研究発表ペーパー・要旨（国際会議）

  • Ventricular Interdependence by Means of Preload Tress Echocardiography in Patients With Pulmonary Hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Kensuke Matsumoto, Kazuhiko Nakayama, Noriaki Emoto, Ken-ichi Hirata
    2017年11月, CIRCULATION, 136, 英語
    研究発表ペーパー・要旨（国際会議）

  • Comprehensive Assessment of Left Atrium for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients With Proximal Atrial Fibrillation
    Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Hiroyuki Sano, Eriko Hisamatsu, Kensuke Matsumoto, Ken-ichi Hirata
    2017年11月, CIRCULATION, 136, 英語
    研究発表ペーパー・要旨（国際会議）

  • 心限局多発血管炎性肉芽腫症の2例
    渡邊 慶明, 河野 淳, 下山 真介, 西井 達矢, 森 俊平, 松本 賢亮, 田中 秀和, 平田 健一, 井上 武, 大北 裕, 高橋 哲, 杉村 和朗
    バイエル薬品(株), 2017年09月, 日独医報, 62(1) (1), 79 - 79, 日本語

  • 負荷心エコーの積極活用(虚血以外) 急性前負荷増大負荷エコーを用いた収縮不全心における予後層別化の試み
    松本 賢亮, 山田 博胤, 平田 健一
    (公社)日本超音波医学会, 2017年04月, 超音波医学, 44(Suppl.) (Suppl.), S209 - S209, 日本語

  • 血清リン値は重度大動脈弁狭窄症患者の総大動脈石灰化負荷量を予測する(Serum Phosphate Level Predicts Total Aortic Calcification Burden in Patients with Severe Aortic Stenosis)
    Terashita Daisuke, Mori Shunpei, Tahara Natsuko, Izawa Yu, Toba Takayoshi, Matsuzoe Hiroki, Matsumoto Kensuke, Tanaka Hidekazu, Ohtake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kono Atsushi, Fujiwara Sei, Hirata Ken-ichi
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, OE - 322, 英語

  • 経胸壁心エコーでの推定とCTでの計測による左室流出路面積の比較(Comparison of the Left Ventricular Outflow Tract Area Estimated by Transthoracic Echocardiography and Measured by Computed Tomography)
    Izawa Yu, Mori Shunpei, Tahara Natsuko, Terashita Daisuke, Toba Takayoshi, Fujiwara Sei, Matsuzoe Hiroki, Matsumoto Kensuke, Tanaka Hidekazu, Ohtake Hiromasa, Shinke Toshiro, Nishii Tatsuya, Kohno Atsushi, Hirata Ken-ichi
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PE - 193, 英語

  • 大動脈弁石灰化の密度は大動脈弁口面積に依存することなく大動脈弁狭窄の血行動態的重症度を予測する(Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area)
    鳥羽 敬義, 森 俊平, 田原 奈津子, 伊澤 有, 寺下 大輔, 松添 弘樹, 松本 賢亮, 田中 秀和, 大竹 寛雅, 藤原 征, 新家 俊郎, 西井 達矢, 河野 淳, 平田 健一
    (一社)日本循環器学会, 2017年03月, 日本循環器学会学術集会抄録集, 81回, PJ - 386, 英語

  • フォンタン術後症候群による蛋白漏出性胃腸症に対して99mTcアルブミンSPECTを施行した1例
    宮崎 秀一郎, 河野 淳, 渡邊 慶明, 西井 達矢, 杉村 和朗, 松本 賢亮
    (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 51 - 51, 日本語

  • 心臓に発生した多発血管炎性肉芽腫症の1例
    下山 真介, 河野 淳, 渡邊 慶明, 西井 達矢, 森 俊平, 松本 賢亮, 田中 秀和, 平田 健一, 井上 武, 大北 裕, 高橋 哲, 杉村 和朗
    日本画像医学会, 2017年02月, Japanese Journal of Diagnostic Imaging, 35(1) (1), 93 - 93, 日本語

  • 左室リードの至適留置位置決定に有用な心臓CT三次元画像再構成法
    津田大輔, 伊澤有, 森俊平, 下山真介, 松添弘樹, 今田宙志, 末廣英也, 中山和彦, 松本賢亮, 田中秀和, 藤原征, 福沢公二, 平田健一
    2017年, 日本循環器学会近畿地方会(Web), 124th

  • 逆Rivero-Carvallo徴候を心臓MRIにて証明したStraight Back Syndromeの一例
    須藤麻貴子, 森俊平, 西井達矢, 伊澤有, 下山真介, 小西弘樹, 松本賢亮, 田中秀和, 平田健一
    2017年, 日本循環器学会近畿地方会(Web), 123rd

  • Utility of End-Systolic Ventricular Elastance for Predicting Post-Operative Left Ventricular Dysfunction in Patients With Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    Junichi Ooka, Hidekazu Tanaka, Kensuke Matsumoto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Impact of Albuminuria on Left Atrial Function Mediated by Left Ventricular Longitudinal Function in Patients With Diabetic Mellitus
    Yasuhide Mochizuki, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Significant Prognostic Values of Acute Preload Stress Echocardiography by Using Leg-positive Pressure Maneuver in Patients With Severe Aortic Stenosis
    Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Predictor of Right Ventricular Reverse Remodeling After Treatment in Patients With Pulmonary Hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Keiko Ryo-Koriyama, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Ventriculo-Arterial Coupling to Detect Hert Failure Symptoms in Patients With Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    Junichi Ooka, Hidekazu Tanaka, Kensuke Matsumoto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Predictor of Right Ventricular Reverse Remodeling After Treatment in Patients With Pulmonary Hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Keiko Ryo-Koriyama, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Significant Prognostic Values of Acute Preload Stress Echocardiography by Using Leg-positive Pressure Maneuver in Patients With Severe Aortic Stenosis
    Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Impact of Albuminuria on Left Atrial Function Mediated by Left Ventricular Longitudinal Function in Patients With Diabetic Mellitus
    Yasuhide Mochizuki, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo -Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    2016年11月, CIRCULATION, 134, 英語
    研究発表ペーパー・要旨（国際会議）

  • 表在エコー検査と心エコー検査のコラボレーションにより感染性心内膜炎が迅速に診断できた僧帽弁逸脱症の1例
    山田 博胤, 楠瀬 賢也, 西條 良仁, 瀬野 弘光, 西尾 進, 山尾 雅美, 天野 里江, 鳥居 裕太, 平田 有紀奈, 田中 秀和, 松本 賢亮, 大北 裕, 佐田 政隆
    (一社)日本心臓病学会, 2016年09月, 日本心臓病学会学術集会抄録, 64回, P - 244, 日本語

  • Effects of a Changeover from Other Angiotensin II Receptor Blockers to Olmesartan on Left Ventricular Hypertrophy in Heart Failure Patients
    Hiroyuki Shimoura, Hidekazu Tanaka, Kensuke Matsumoto, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Ryo Koriyama, Ken-Ichi Hirata
    2016年09月, JOURNAL OF CARDIAC FAILURE, 22(9) (9), S197 - S197, 英語
    研究発表ペーパー・要旨（国際会議）

  • Keiko Ryo-Koriyama, Kensuke Matsumoto, Tatsuya Nishii, Hidekazu Tanaka, Ken-Ichi Hirata
    2016年06月, European heart journal cardiovascular Imaging, 17(6) (6), 706 - 706, 英語, 国際誌
    [査読有り]

  • 2回のリード抜去を要した後にシリコン被膜が残存し開胸にて摘出となったデバイス感染の一例
    市堀博俊, 木内邦彦, 福沢公二, 小西弘樹, 今田宙志, 兵庫聖大, 黒瀬潤, 末廣英也, 永松裕一, 秋田朋己, 松本賢亮, 森俊平, 平田健一, 西井達矢, 山田貴之
    2016年, 日本循環器学会近畿地方会(Web), 122nd

  • Association of Three-Dimensional Tricuspid Valve Deformation With Functional Tricuspid Regurgitation
    Keiko Ryo, Hidekazu Tanaka, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Hiroyuki Sano, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Kazuhiro Tatsumi, Kensuke Matsumoto, Ken-ichi Hirata
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • Increasing Stimulus Strength of Coronary Sinus Pacing Improved Left Ventricular Mechanical Dyssynchrony and Contractile Function in Patients With Reduced Ejection Fraction
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Dokuni Kumiko, Yutaka Hatani, Keiko Hatazawa, Hiroaki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Hiroyuki Shimoura, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Koji Fukuzawa, Ken-ichi Hirata
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • Risk Stratification of Future Left Ventricular Dysfunction in Patients With Indications for Right Ventricular Pacing Owing to Bradycardia
    Junichi Ooka, Hidekazu Tanaka, Yutaka Hatani, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Hiroyuki Sano, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Ken-ichi Hirata
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • Assessment of Bi-ventricular Contractile Reserve for Patients with Left-sided Heart Failure
    Hidekazu Tanaka, Kensuke Matsumoto, Ken-Ichi Hirata
    2015年10月, JOURNAL OF CARDIAC FAILURE, 21(10) (10), S152 - S152, 英語
    研究発表ペーパー・要旨（国際会議）

  • 三尖弁輪変形における機能的三尖弁閉鎖不全との関連性 三次元心エコー解析から得られた洞察(Association in the Tricuspid Annular Deformation with Functional Tricuspid Regurgitation: Insights from Three Dimensional Echocardiographic Analysis)
    Ryo Keiko, Tanaka Hidekazu, Inomata Kumiko, Hatani Yu, Hatazawa Keiko, Matsuzoe Hiroki, Shimoura Hiroyuki, Ooka Junichi, Toki Hiromi, Sano Hiroyuki, Sawa Takuma, Mochizuki Yasuhide, Motoji Yoshiki, Matsumoto Kensuke, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 1893 - 1893, 英語

  • 左室駆出率が保持された糖尿病患者におけるアルブミン尿が無症候性左室機能不全に及ぼす影響(Impact of Albuminuria on Subclinical Left Ventricular Dysfunction in Patients with Diabetic Mellitus and Preserved Left Ventricular Ejection Fraction)
    Mochizuki Yasuhide, Tanaka Hidekazu, Doukuni Kumiko, Hatani Yutaka, Hatazawa Keiko, Matsuzoe Hiroki, Toki Hiromi, Shimoura Hiroyuki, Ooka Junichi, Sano Hiroyuki, Sawa Takuma, Motoji Yoshiki, Ryo Keiko, Matsumoto Kensuke, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 2405 - 2405, 英語

  • 肺高血圧患者における右室収縮機能と左室充満の相互依存および転帰との関連(Interdependence of Right Ventricular Systolic Function and Left Ventricular Filling and its Association with Outcome in Patients with Pulmonary Hypertension)
    Motoji Yoshiki, Tanaka Hidekazu, Fukuda Yuko, Sano Hiroyuki, Ryo Keiko, Hatani Yu, Hatazawa Keiko, Matsuzoe Hiroki, Shimoura Hiroyuki, Toki Hiromi, Ooka Junichi, Sawa Takuma, Mochizuki Yasuhide, Matsumoto Kensuke, Emoto Noriaki, Hirata Ken-ichi
    (一社)日本循環器学会, 2015年03月, Circulation Journal, 79(Suppl.I) (Suppl.I), 2882 - 2882, 英語

  • Yasuhide Mochizuki, Hidekazu Tanaka, Kumiko Doukuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Keiko Ryo, Kensuke Matsumoto, Ken-ichi Hirata
    2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1234 - A1234, 英語
    研究発表ペーパー・要旨（国際会議）

  • Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Hiroyuki Sano, Kumiko Dokuni, Yutaka Hatani, Hiroyuki Shimoura, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Junichi Ooka, Takuma Sawa, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1532 - A1532, 英語
    研究発表ペーパー・要旨（国際会議）

  • Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A1557 - A1557, 英語
    研究発表ペーパー・要旨（国際会議）

  • Combined Assessment of Right Ventricular Function and Reverse Remodeling as Prognostic Marker after Administration of Medical Treatment for Pulmonary Hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Takuma Sawa, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2014年11月, CIRCULATION, 130, 英語
    研究発表ペーパー・要旨（国際会議）

  • Utility of Combined Assessment of Exercise Oscillatory Breathing and Global Circumferential Strain to Predict Cardiac Events in Heart Failure Patients
    Hidekazu Tanaka, Yasunori Tsuboi, Kensuke Matsumoto, Kuniko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Kazuhiro Tatsumi, Yoshitada Sakai, Ken-ichi Hirata
    2014年11月, CIRCULATION, 130, 英語
    研究発表ペーパー・要旨（国際会議）

  • Right Atrial Function as Prognostic factor in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Hiroki Matsuzoe, Keiko Hatazawa, Yutaka Hatani, Kumiko Dokuni, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    2014年11月, CIRCULATION, 130, 英語
    研究発表ペーパー・要旨（国際会議）

  • Is Cardiac Resynchronization Theraphy Contraindicated in Heart Failure Patients with A Narrow QRS Complex?
    Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Akihiro Yoshida, Ken-Ichi Hirata
    2014年10月, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S186 - S186, 英語
    研究発表ペーパー・要旨（国際会議）

  • 【心不全治療戦略の最前線-その点描】 ガイドラインからみた心不全診療
    松本 賢亮, 平田 健一
    科学評論社, 2014年08月, 循環器内科, 76(2号) (2号), 100 - 107, 日本語
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • EFFICACY OF SEGMENTAL CIRCUMFERENTIAL STRAIN ANALYSIS AS A PARAMETER OF INTRINSIC LEFT VENTRICULAR MYOCARDIAL FUNCTION FOR CARDIAC RESYNCHRONIZATION THERAPY
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Yoshiki Motoji, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1185 - A1185, 英語
    研究発表ペーパー・要旨（国際会議）

  • ASSOCIATION OF APICAL LONGITUDINAL ROTATION WITH TRICUSPID ANNULAR PLANE SYSTOLIC EXCURSION IN PATIENTS WITH PULMONARY HYPERTENSION
    Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Toshiro Shinke, Noriaki Emoto, Ken-ichi Hirata
    2014年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(12) (12), A1487 - A1487, 英語
    研究発表ペーパー・要旨（国際会議）

  • 三尖弁閉鎖不全症を合併した卵円孔開存に伴う低酸素血症の一例
    下浦 広之, 田中 秀和, 松本 賢亮, 土岐 啓己, 今西 純一, 三好 達也, 元地 由樹, 望月 泰秀, 佐和 琢磨, 平田 健一
    2014年04月, 超音波医学, 41(Suppl.) (Suppl.), S522, 日本語
    会議報告等

  • 好酸球増加症における左室心内膜障害の検討
    山本 哲志, 田中 秀和, 松本 賢亮, 三好 達也, 今西 純一, 栗本 千代, 今西 孝充, 林 伸英, 平田 健一, 河野 誠司
    2014年04月, 超音波医学, 41(Suppl.) (Suppl.), S505, 日本語
    会議報告等

  • シャント量の少ない心房中隔欠損症に対する経カテーテル的閉鎖術の意義
    佐和 琢磨, 田中 秀和, 平石 真奈, 元地 由樹, 今西 純一, 三好 達也, 望月 泰秀, 松本 賢亮, 新家 俊郎, 平田 健一
    2014年04月, 超音波医学, 41(Suppl.) (Suppl.), S511, 日本語
    会議報告等

  • Glen手術既往のある心室頻拍患者に対して,心外膜にICDリードを留置した1例
    小西弘樹, 福沢公二, 吉田明弘, 松本賢亮, 藤原竜童, 鈴木敦, 中西智之, 山下宗一郎, 松本晃典, 市堀博俊, 山下智也, 高谷具史, 井上武, 大北裕, 平田健一
    2014年, 日本循環器学会近畿地方会(Web), 117th

  • Duchenne型筋ジストロフィー患者の潜在性左室心筋障害の検出における下肢挙上負荷心エコー図検査の有用性
    山本哲志, 田中秀和, 竹島泰弘, 土岐啓巳, 下浦広之, 大岡順一, 佐野浩之, 佐和琢磨, 山鳥嘉樹, 元地由樹, 三好達也, 今西純一, 望月泰秀, 福田優子, 辰巳和宏, 今西孝光, 松本賢亮, 林伸英, 平田健一, 河野誠司
    2014年, 日本心エコー図学会学術集会抄録集, 25th, 173, 日本語

  • Left Atrial "Reservoir" and "Passive Emptying" Reserve During Dobutamine Stress Have Prognostic Relevance for Patients With Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Yasuhide Mochizuki, Tatsuya Miyoshi, Yoshiki Motoji, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Tissue Doppler Derived Mitral Annular Velocity and Acceleration During Isovolumic Contraction Predict Pulmonary Capillary Wedge Pressure in Patients With Significant Mitral Regurgitation
    Alaa M. Omar, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Mohammed A. Abdel-Rahman, Hala M. Raslan, Osama Rifaie, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Endocardial Area Change Rate by Three-dimensional Speckle-tracking as an Accurate Predictor of Left Ventricular Relaxation
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Toshiro Shinke, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Easy-to-Use Comprehensive Speckle Tracking Evaluation to Minimize Non-Responders Following Cardiac Resynchronization Therapy
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Yoshiki Motoji, Yuko Fukuda, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Evaluation of Global Circumferential Strain as Prognostic Marker After Administration of beta-blockers for Dilated Cardiomyopathy
    Hidekazu Tanaka, Yasuhide Mochizuki, Kensuke Matsumoto, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Interdependence in the Biventricle and Its Association With Long-Term Outcome in Patients With Pulmonary Hypertension
    Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Yoshiki Yamadori, Takuma Sawa, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Assessment of Bi-ventricular Functional Reserve During Dobutamine Stress Offers a Significant Prognostic Impact for Patients With Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Tatsuya Miyoshi, Yuko Fukuda, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Association of Left Atrial Booster-Pump Function With Heart Failure Symptoms in Patients With Severe Aortic Stenosis and Preserved Ejection Fraction
    Junichi Imanishi, Hidekazu Tanaka, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kensuke Matsumoto, Kazuhiro Tatsumi, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • Evaluation of Time Course of Left Ventricular Dysfunction by Cardiotoxicity of Anthracycline
    Tatsuya Miyoshi, Hidekazu Tanaka, Akihiro Kaneko, Kensuke Matsumoto, Kazuhiro Tatsumi, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Yuko Fukuda, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
    2013年11月, CIRCULATION, 128(22) (22), 英語
    研究発表ペーパー・要旨（国際会議）

  • 肺高血圧症における左室局所心筋拡張能指標の有用性
    元地 由樹, 田中 秀和, 福田 優子, 佐和 琢磨, 山鳥 嘉樹, 今西 純一, 三好 達也, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    2013年09月, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 337, 日本語
    会議報告等

  • 心臓再同期療法における2次元スペックルトラッキング法を用いた簡便かつ有用な評価法 左室同期不全と左室心筋機能評価の検討
    望月 泰秀, 田中 秀和, 松本 賢亮, 辰巳 和宏, 今西 純一, 佐和 琢磨, 三好 達也, 元地 由樹, 山鳥 嘉樹, 福田 優子, 川合 宏哉, 平田 健一, 横山 光宏
    2013年09月, 日本心臓病学会誌, 8(Suppl.I) (Suppl.I), 379, 日本語
    会議報告等

  • 左心不全患者における左室拡張機能と心臓交感神経障害の関連
    山鳥 嘉樹, 大西 哲存, 茂 真由美, 松本 賢亮, 田中 秀和, 藤原 征, 川合 宏哉, 平田 健一
    2013年04月, 超音波医学, 40(Suppl.) (Suppl.), S459, 日本語
    会議報告等

  • Duchenne型筋ジストロフィーにおける機能的僧帽弁閉鎖不全症と僧帽弁形態について
    山本 哲志, 田中 秀和, 松本 賢亮, 金子 明弘, 今西 孝充, 林 伸英, 竹島 泰弘, 川合 宏哉, 平田 健一, 河野 誠司
    (公社)日本超音波医学会, 2013年04月, 超音波医学, 40(Suppl.) (Suppl.), S481 - S481, 日本語
    会議報告等

  • EASY-TO-USE COMPREHENSIVE SPECKLE TRACKING APPROACH TO MINIMIZE NON-RESPONDERS TO CARDIAC RESYNCHRONIZATION THERAPY
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Kenichi Hirata
    2013年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 61(10) (10), E1088 - E1088, 英語
    研究発表ペーパー・要旨（国際会議）

  • Acute Reduction in Strain Dyssynchrony Index with Cardiac Resynchronization Therapy Predicts Mid-Term Left Ventricular Reverse-remodeling and Long-Term Outcome: Using Two-dimensional Speckle-tracking Study
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kanako, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    2012年11月, CIRCULATION, 126(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Contractile Reserve Assessed by Three-Dimensional Global Circumferential Strain as a Predictor of Cardiovascular Events in Patients with Idiopathic Dilated Cartliomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    2012年11月, CIRCULATION, 126(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Correlation between Right Arterial Pressure and Right Arterial Volume Index in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Takuma Sawa, Yasuhide Mochizuki, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    2012年11月, CIRCULATION, 126(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Feature of Mechanical Left Ventricular Dyssynchrony in Heart Failure Patients with "Very" Narrow QRS Duration: Using Three-dimensional Speckle-tracking Study
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    2012年11月, CIRCULATION, 126(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Dynamic Left Ventricular Dyssynchrony Assessed by Three Dimensional Speckle-Tracking Area Strain during Dobutamine Stress Has a Negative Impact on Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    2012年11月, CIRCULATION, 126(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Duchenne型筋ジストロフィーにおける機能的僧帽弁逆流と左房径の関係について
    山本哲志, 田中秀和, 松本賢亮, 漁恵子, 今西孝充, 林伸英, 竹島泰弘, 川合宏哉, 河野誠司, 平田健一
    (公社)日本超音波医学会, 2012年04月15日, 超音波医学, 39(Suppl.) (Suppl.), S368 - S368, 日本語

  • EVALUATION OF LEFT VENTRICULAR FILLING PRESSURES USING TISSUE DOPPLER DERIVED MYOCARDIAL ACCELERATION DURING ISOVOLUMIC CONTRACTION
    Alaa Omar, Hidekazu Tanaka, Kensuke Matsumoto, Yoshiki Motoji, Junichi Imanishi, Tatsuya Myoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1124 - E1124, 英語
    研究発表ペーパー・要旨（国際会議）

  • CONTRACTILE RESERVE ASSESSED BY THREE-DIMENSIONAL GLOBAL CIRCUMFERENTIAL STRAIN AS A PREDICTOR OF LONG-TERM OUTCOME IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    2012年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59(13) (13), E1141 - E1141, 英語
    研究発表ペーパー・要旨（国際会議）

  • 急激に悪化した小児ミトコンドリア心筋症の一例
    林繭子, 田中秀和, 山本哲志, 李知子, 粟野宏之, 松本賢亮, 今西孝充, 林伸英, 竹島泰弘, 河野誠司, 川合宏哉, 平田健一
    2012年, 日本心エコー図学会学術集会抄録集, 23rd, 193, 日本語

  • Multidirectional Left Ventricular Performance Using Three-Dimensional Speckle-Tracking Strain in Patients with Chronic Right Ventricular Pacing and Preserved Ejection Function
    Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, HIroya Kawai, Ken-ichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Endocardial Dysfunction in Patients with Chronic Aortic Regurgitation and Preserved Ejection Fraction
    Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Kenichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Ability of Comprehensive Assessment of Strain Dyssynchrony Index by Speckle Tracking Imaging to Predict Long-Term Outcome After Cardiac Resynchronization Therapy in Patients with Heart Failure
    Kazuhiro Tatsumi, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Utility of Three-Dimensional Speckle Tracking Radial Strain for Identifying Patients with Cardiac Sarcoidosis
    Takayuki Tsuji, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Left Ventricular Dyssynchrony as a Determinant of Torsional Mechanics in Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Regional Heterogeneity of Systolic Dysfunction Leads to Ventricular Dyssynchrony in Patients with Idiopathic Dilated Cardiomyopathy and Narrow QRS Complex; 3-Dimensional Speckle-Tracking Strain Analysis
    Kensuke Matsumoto, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Kohei Yamawaki, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Tetsuari Ohnishi, Hiroya Kawai, Ken-ichi Hirata
    2011年11月, CIRCULATION, 124(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • 心筋障害及び左室内血栓を伴うSLE症候群の1例
    上野大輔, 大石醒悟, 鳥羽敬義, 寺西仁, 三好直貴, 月城泰栄, 觀田学, 横井公宣, 高谷具史, 福沢公二, 嶋根章, 岡嶋克則, 山田愼一郎, 谷口泰代, 林孝俊, 西岡成知, 森本直人, 向原伸彦, 松本賢亮, 横山光宏
    2011年, 日本循環器学会近畿地方会(Web), 112th

  • 左室正常壁運動のDuchenne型筋ジストロフィーにおけるradial strain中に見られたノッチの臨床的意義について
    山本哲志, 川合宏哉, 平石真奈, 三好達也, 辻隆之, 金子明弘, 漁恵子, 山脇康平, 福田優子, 辰巳和宏, 則定加津子, 粟野宏之, 松本賢亮, 田中秀和, 林伸英, 木下承晧, 竹島泰弘, 平田健一, 松尾雅文, 河野誠司
    2011年, 日本心エコー図学会学術集会抄録集, 22nd, 145, 日本語

  • Regional Myocardial Systolic Function Using Transmural Myocardial Strain Profile Predicts Postoperative Left Ventricular Systolic Dysfunction in Chronic Aortic Regurgitation
    Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Takayuki Tsuji, Kouhei Yamawaki, Keiko Ryo, Alaa M. Omar, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    2010年11月, CIRCULATION, 122(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Area Strain Delay Index by Three-dimensional Speckle Tracking Imaging Predicts Left Ventricular Reverse Remodeling with Cardiac Resynchronization Therapy
    Kazuhiro Tatsumi, Hidekazu Tanaka, Takayuki Tsuji, Akihiro Kaneko, Kouhei Yamawaki, Keiko Ryo, Alaa M. Omar, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    2010年11月, CIRCULATION, 122(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Loffler's Endocarditis With Severely Impaired Left Ventricular Function and Thrombus
    Takayuki Tsuji, Hidekazu Tanaka, Akihiro Kaneko, Keiko Ryo, Kouhei Yamawaki, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-Ichi Hirata
    2010年09月, JOURNAL OF CARDIAC FAILURE, 16(9) (9), S161 - S161, 英語
    研究発表ペーパー・要旨（国際会議）

  • Left Ventricular Dyssynchrony With Sever Aortic Valve Stenosis is Improved With Aortic Valve Replacement
    Kohei Yamawaki, Hiroya Kawai, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Tetsuari Onishi, Okita Yutaka, Ken-Ichi Hirata
    2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S166 - S166, 英語
    研究発表ペーパー・要旨（国際会議）

  • Reverse Remodeling Induces Progressive Ventricular Resynchronization After Cardiac Resynchronization Therapy - From Vicious to Virtuous Cycle
    Kensuke Matsumoto, Hiroya Kawai, Keiko Ryo, Tetsuari Onishi, Kenichi Hirata
    2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S180 - S180, 英語
    研究発表ペーパー・要旨（国際会議）

  • The Usefulness of Handgrip Stress Echocardiography With Segmental Stsystolic Strain Analysis in Patients With Coronary Artery Disease
    Keiko Ryo, Hiroya Kawai, Kouhei Yamawaki, Yuko Fukuda, Mariko Okada, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Tetsuari Oonishi, Ken-Ichi Hirata
    2009年09月, JOURNAL OF CARDIAC FAILURE, 15(7) (7), S160 - S160, 英語
    研究発表ペーパー・要旨（国際会議）

  • ST-Segment Resolution after Primary Percutaneous Intervention is Strongly Associated with Improvement of Cardiac Function Only in Anterior Myocardial Infarction
    Hiroyuki Shibata, Shinichiro Yamada, Takatoshi Hayashi, Yasuyo Yaniguchi, Kazuo Mizutani, Sachiyo Iwata, Katsunori Okajima, Akira Shimane, Masahiro Kumada, Kensuke Matsumoto, Yasue Tsukishiro, Takumi Inoue, Teishi Kajiya
    2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A54 - A54, 英語
    研究発表ペーパー・要旨（国際会議）

  • 7) 右下肢痛を主訴で来院した急性心筋梗塞症の一例(第105回日本循環器学会近畿地方会)
    井上 琢海, 谷口 泰代, 林 孝俊, 山田 慎一郎, 水谷 和郎, 岩田 幸代, 岡嶋 克則, 嶋根 章, 松本 賢亮, 月城 泰栄, 熊田 全裕, 今村 公威, 田代 雅裕, 梶谷 定志
    社団法人日本循環器学会, 2008年10月20日, Circulation journal : official journal of the Japanese Circulation Society, 72, 1092 - 1092, 日本語

  • Evaluation of Coronary Artery Plaque Tissue Characterization by Cardiac Magnetic Resonance Imaging
    Yasuyo Taniguchi, Tsuyoshi Ishimoto, Sachiyo Iwata, Shinitchiro Yamada, Masahiro Kumada, Akira Shimane, Kazuo Mizutani, Yasue Tsukishiro, Kensuke Matsumoto, Gaku Kanda, Katsunori Okajima, Takatoshi Hayashi, Teishi Kajiya
    2008年10月, CIRCULATION, 118(18) (18), S997 - S997, 英語
    研究発表ペーパー・要旨（国際会議）

  • Mechanisms of Reduction of Mitral Regurgitation by Cardiac Resynchronization Therapy: By Analysis of Left Ventricular Morphology
    Kensuke Matsumoto, Teishi Kajiya, Takatosh Hayashi, Yasuyo Taniguchi, Shinichiro Yamada, Kazuo Mizutani, Sachiyo Iwata, Akira Shimane, Katsunori Okajima, Masahiro Kumada, Yasue Tsukishiro, Gaku Kanda, Takumi Inoue, Kimitake Imamura, Tatsu Tagashira, Mana Hiraishi, Masahiro Tashiro
    2008年10月, CIRCULATION, 118(18) (18), S868 - S868, 英語
    研究発表ペーパー・要旨（国際会議）

  • Prognostic significance of diastolic filling pattern in Cardiac resynchronization therapy
    Yasue Tsukishiro, Kensuke Matsumoto, Takatoshi Hayashi, Yasuyo Taniguchi, Kazuo Mizutani, Katsunori Okajima, Akira Shimane, Manabu Kanda, Teishi Kajiya
    2008年09月, JOURNAL OF CARDIAC FAILURE, 14(7) (7), S170 - S170, 英語
    研究発表ペーパー・要旨（国際会議）

  • Mechanisms of reduction of mitral regurgitation by cardiac resynchronization therapy: by analysis of left ventricular morphology
    Kensuke Matsumoto, Teishi Kajiya, Takatoshi Hayashi, Yasuyo Taniguchi, Shinichirou Yamada, Kazuo Mizutani, Sachiyo Iwata, Akira Shimane, Katsunori Okajima, Yasue Oka
    2008年09月, JOURNAL OF CARDIAC FAILURE, 14(7) (7), S148 - S148, 英語
    研究発表ペーパー・要旨（国際会議）

  • Gender difference of sirolimus-eluting stent expansion evaluated by intravascular ultrasound
    Shinichiro Yamada, Amane Kozuki, Takatoshi Hayashi, Sachiyo Iwata, Masahiro Kumada, Yusuke Kurogane, Yasuyo Taniguchi, Kazuo Mizutani, Katsunori Okajima, Akira Shimane, Kensuke Matsumoto, Yasue Tsukishiro, Teishi Kapya
    2008年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), B6 - B6, 英語
    研究発表ペーパー・要旨（国際会議）

  • 13)drug eluting stent (DES)のstent fractureに対しbear metal stent (BMS)を施用した一例(第103回日本循環器学会近畿地方会)
    漁 恵子, 林 孝俊, 池田 嘉弘, 山田 慎一郎, 岩田 幸代, 谷口 泰代, 水谷 和郎, 岡嶋 克則, 松本 賢亮, 衣笠 充雄, 今村 公威, 銕 佑介, 梶谷 定志
    社団法人日本循環器学会, 2007年10月20日, Circulation journal : official journal of the Japanese Circulation Society, 71, 990 - 990, 日本語

  • Preserved cardiac sympathetic nerve innervation contributes to left ventricular reverse remodeling after acute myocardial infarction: Analysis by MIBG imaging
    Kensuke Matsumoto, Teish Kajiya, Takatoshi Hayashi, Yoshihiro Ikeda, Shinichirou Yamada, Kouhei Yamashiro, Kazuo Mizutani, Sachiyo Iwata, Katsunori Okajima, Masami Yoshida, Mitsuo Kinugasa, Naoki Murai
    2006年10月, CIRCULATION, 114(18) (18), 638 - 638, 英語
    研究発表ペーパー・要旨（国際会議）

  • MIBG scintigraphy as a potent method for identifying responders receiving CRT
    Naoki Murai, Kohei Yamashiro, Kazuo Mizutani, Katsunori Okajima, Kensuke Matsumoto, Takatoshi Hayashi, Yoshihiro Ikeda, Shinichiro Yamada, Sachiyo Iwata, Mitsuo Kinugasa, Teishi Kajiya
    2006年10月, CIRCULATION, 114(18) (18), 764 - 764, 英語
    研究発表ペーパー・要旨（国際会議）

■ 書籍等出版物
  • 心エコーで診る抗腫瘍薬の心毒性
    畑澤圭子、松本賢亮
    共著, 文光堂, 2020年01月

  • あなたのエコーで予後を知る / 拡張型および肥大型心筋症の予後を知る
    松本賢亮
    単著, 文光堂, 2019年07月, 日本語
    学術書

  • 雑誌心エコー / 修復後の大血管転位
    松本賢亮
    その他, 文光堂, 2017年06月, 日本語
    学術書

  • 心不全患者の失敗 しない弁膜症治療 / 大動脈弁狭窄治療におけるハートチームの意義とは
    松添弘樹, 松本賢亮
    その他, 文光堂, 2017年04月, 日本語
    学術書

  • Medicina『総合内科医の臨床必修問題 183問』 / 先天性心疾患
    松本賢亮
    その他, 医学書院, 2017年04月, 日本語
    学術書

  • 重症心不全の患者さんが来ました / アルドステロン拮抗薬
    松本賢亮
    その他, 中外医学社, 2016年09月, 日本語
    学術書

  • 心エコー「三尖弁と右室機能」 / 心エコーによる右室の見方
    松本賢亮
    その他, 文光堂, 2016年03月, 日本語
    学術書

  • 循環器研修医ノート / 修正大血管転位症
    松本賢亮
    その他, 診断と治療社, 2016年03月, 日本語
    学術書

  • 循環器研修医ノート / ファロー四徴症
    松本賢亮
    その他, 診断と治療社, 2016年03月, 日本語
    学術書

  • Vascular Lab / 肺塞栓症を見る
    松本賢亮, 川合宏哉
    その他, メディカ出版, 2015年12月, 日本語
    学術書

  • 心エコー「今こそ！負荷心エコー法」 / 拡張型心筋症に対する負荷エコー法
    松本賢亮
    その他, 文光堂, 2015年07月, 日本語
    学術書

  • 心エコー「ピットフォール！ピットフォール！ピットフォール！」 / 大動脈弁閉鎖不全症診療のピットフォール
    松本賢亮
    その他, 文光堂, 2015年03月, 日本語
    学術書

  • 循環器内科 / ガイドラインからみた心不全診療
    松本賢亮, 平田健一
    その他, 科学評論社, 2014年08月, 日本語
    学術書

  • 心エコー「3次元心エコーの臨床－Case Based Reviews－」 / 3次元心エコーが有用であった大動脈弁膜症例
    松本賢亮, 川合宏哉
    その他, 文光堂, 2012年11月, 日本語
    学術書

  • 心エコー / 5.手術を受けていない成人先天性心疾患に対する心エコー 左室流出路異常と大動脈異常 －大動脈弁か狭窄・大動脈弁上狭窄・大動脈縮窄・Valsalva洞動脈瘤-
    松本賢亮, 川合宏哉
    その他, 文光堂, 2012年03月, 日本語
    学術書

  • 拡張期学―Diastologyのすべて / 「弁膜疾患‐弁膜疾患における左室拡張不全の位置付け‐」
    松本賢亮, 川合宏哉
    その他, 文光堂, 2010年09月, 日本語
    学術書

■ 講演・口頭発表等
  • ファロー四徴症における未解決な問題
    松本賢亮
    2020年日本成人先天性心疾患学会総会, 2020年01月, 日本語
    口頭発表（一般）

  • ACHD診療における緩和ケア〜『語り』の立場から
    松本賢亮
    第22回成人先天性心疾患学会総会・学術集会, 2020年01月, 日本語
    シンポジウム・ワークショップパネル（公募）

  • 心不全における負荷心エコー図
    松本賢亮
    アメリカ心エコー図学会, 2019年06月, 英語
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • Impact of Glycemic Variability on Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus
    Shun Yokota, Hidekazu Tanaka, Yasuhide Mochizuki, Fumitaka Soga, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Sachiko Yoshikawa, Keiko Sumimoto, Nao Shibata, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 英語, 横浜, 国内会議
    口頭発表（一般）

  • Impact of Glycemic Variability on Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus
    Shun Yokota, Hidekazu Tanaka, Yasuhide Mochizuki, Fumitaka Soga, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Sachiko Yoshikawa, Keiko Sumimoto, Nao Shibata, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • Impact of Dapagliflozin on Left Ventricular Diastolic Function of Patients with Type 2 Diabetic Mellitus with Chronic Heart Failure
    Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 横浜, 国内会議
    口頭発表（一般）

  • Effect of Dapagliflozin on Left Ventricular Diastolic Function of Patients with Type 2 Diabetic Mellitus with Chronic Heart Failure
    Fumitaka Soga, Hidekazu Tanaka, Kazuhiro Tatsumi, Yasuhide Mochizuki, Hiroyuki Sano, Hiromi Toki, Kensuke Matsumoto, Junya Shite, Hideyuki Takaoka, Tomofumi Doi, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • Comprehensive Simplified Left Atrial Assessment for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation
    Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Sachiko Yoshikawa, Keiko Sumimoto, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Koji Fukuzawa, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • Comprehensive Simplified Left Atrial Approach for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients with Atrial Fibrillation
    Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Kentaro Yamashita, Yusuke Tanaka, Ayu Shono, Makiko Suzuki, Sachiko Yoshikawa, Keiko Sumimoto, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Koji Fukuzawa, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 横浜, 国内会議
    ポスター発表

  • Association of Tricuspid Regurgitation with Long-Term Outcome in Patients with Pulmonary Hypertension
    Jun Mukai, Hidekazu Tanaka, Hiroyuki Sano, Shun Yokota, Nao Shibata, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 横浜, 国内会議
    ポスター発表

  • Association of Tricuspid Regurgitation with Long-Term Outcome in Patients with Pulmonary Hypertension
    Jun Mukai, Hidekazu Tanaka, Hiroyuki Sano, Shun Yokota, Nao Shibata, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • Association of Body Fat Mass with Left Ventricular Myocardial Systolic Longitudinal Dysfunction in Type 2 Diabetes Mellitus
    Yutaka Hatani, Hidekazu Tanaka, Yasuhide Mochizuki, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • A Case of Sudden Onset of Platypnea-Orthodeoxia Syndrome Caused by Traumatic Tricuspid Regurgitation with Ruptured Chordae Tendineae After Blunt Chest Trauma
    Yutaka Hatani, Hidekazu Tanaka, Keiko Sumimoto, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 68th Annual Scientific Session of the American College of Cardiology, 2019年03月, 英語, New Orleans, 国際会議
    ポスター発表

  • K君の物語
    松本 賢亮, 小林 成美, 平田 健一
    第4回日本心臓リハビリテーション学会近畿地方会, 2019年02月, 日本語, 日本心臓リハビリテーション学会, 京都, 神戸大学で経験した心臓病緩和の物語。, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 中等度の心奇形 (AVSDとEbstein病)
    松本 賢亮, 城戸 佐知子, 鈴木 麻希子, 須藤 麻貴子, 平田 健一
    第21回 日本成人先天性心疾患学会, 2019年01月, 日本語, 日本成人先天性心疾患学会, 岡山, 中等度の心奇形であるAVSDとEbstein病について概説する。, 国内会議
    公開講演，セミナー，チュートリアル，講習，講義等

  • 神戸大学ACHDセンターの実際
    松本 賢亮, 城戸 佐知子, 鈴木 麻希子, 須藤 麻貴子, 平田 健一
    第21回 日本成人先天性心疾患学会, 2019年01月, 日本語, 日本成人先天性心疾患学会, 岡山, 神戸大学成人先天性心疾患センターでの診療の実際につき紹介する。, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • Non-invasive assessment of preload reserve using the leg-positive pressure maneuver in patients with repaired tetralogy of Fallot
    Makiko Suto, Kensuke Matsumoto, Makiko Suzuki, Sachiko Kido, Kenichi Hirata
    第21回 日本成人先天性心疾患学会, 2019年01月, 日本語, 日本成人先天性心疾患学会, 岡山, 国内会議
    口頭発表（一般）

  • Shortened Posterior Mitral Leaflet in Patients with Atrial Fibrillation and Significant Mitral Regurgitation
    Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Nao Shibata, Jun Mukai, Makiko Suto, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 45th Annual Scientific Meeting of the Korean Society of Echocardiography, 2018年11月, 英語, Seoul, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • Comprehensive Three-dimensional Reconstruction of Adult Congenital Heart
    Yu Izawa, Shumpei Mori, Shinsuke Shimoyama, Kensuke Matsumoto, Justin T. Tretter, Diane E. Spicer, Kenichi Hirata, Robert H. Anderson
    RSNA 2018, 2018年11月, 英語, Chicago, 国際会議
    ポスター発表

  • 疣腫を見誤った一例
    曽我 文隆, 田中 秀和, 須藤 麻貴子, 堂國 久美子, 向井 淳, 高田 裕基, 畑澤 圭子, 松本 賢亮, 平田 健一, 田中 裕史
    日本超音波医学会 第45 回関西地方会学術集会, 2018年10月, 日本語, 神戸, 国内会議
    口頭発表（一般）

  • 経カテーテル的心房中隔閉鎖術が奏功した超高齢者重症心不全の一例
    鈴木麻希子, 松本賢亮, 須藤麻貴子, 谷村幸亮, 中野慎介, 谷口弥生, 田中秀和, 大竹寛雅, 新家俊郎, 平田健一
    日本超音波医学会 第45 回関西地方会学術集会, 2018年10月, 日本語, 神戸, 国内会議
    口頭発表（一般）

  • Therapeutic Strategy and Predicting Prognosis in Patients of Fulminant Myocarditis with Mechanical Circulatory Support
    Eriko Hisamatsu, Kensuke Matsumoto, Nao Shibata, Shun Yokota, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Hidekazu Tanaka, Hiroshi Tanaka, Kenichi Hirata
    第22回心不全学会学術集会, 2018年10月, 日本語, 東京, 国内会議
    口頭発表（一般）

  • Integrated assessment of aortic valve resistance using multi-detector computed tomography and echocardiography reflects aortic valvular burden and has prognostic value in patients with aortic stenosis
    Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Natsuko Tahara, Yu Izawa, Takayoshi Toba, Shumpei Mori, Makiko Suto, Jun Mukai, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Shinsuke Shimoyama, Kenichi Hirata
    European Society of Cardiology Congress 2018, 2018年09月, 英語, Munich, 国際会議
    ポスター発表

  • Association of Relatively Shortened Posterior Mitral Leaflet with Mitral Regurgitation in Atrial Fibrillation
    Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Nao Shibata, Jun Mukai, Makiko Suto, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    第66回日本心臓病学会学術集会, 2018年09月, 英語, 大阪, 国内会議
    口頭発表（一般）

  • Non-invasive assessment of preload reserve using the leg-positive pressure manoeuvre in patients with repaired tetralogy of Fallot
    Makiko Suto, Kensuke Matsumoto, Nao Shibata, Shun Yokota, Jun Mukai, Eriko Hisamatsu, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hidekazu Tanaka, Kenichi Hirata
    European Society of Cardiology Congress 2018, 2018年08月, 英語, Munich, 国際会議
    ポスター発表

  • 不整脈および左室収縮機能障害を合併した、抗ミトコンドリアM2抗体陽性筋炎の1例
    竹本 良, 松本 賢亮, 柴田 奈緒, 黒田 浩史, 小林 成美, 田中 秀和, 平田 健一, 関口 兼司, 全 陽
    第126回 日本循環器学会近畿地方会, 2018年06月, 日本語, 大阪, 国内会議
    口頭発表（一般）

  • 肺高血圧症における三尖弁閉鎖不全症と長期予後との関係
    向井淳, 田中秀和, 佐野浩之, 高田裕基, 曽我文隆, 羽渓優, 畑澤圭子, 松添弘樹, 松本賢亮, 平田健一
    日本超音波医学会 第91回学術集会, 2018年06月, 日本語, 神戸, 【背景】肺高血圧症（PH）の予後には様々な因子が複雑に関与しており、その予測は単純ではない。近年、三尖弁閉鎖不全症（TR）が様々な心不全患者の予後予測に有用であり、独立した予後予測因子であると報告されている。しかしながら、TRとPH患者の予後との関連、さらにPH治療によるTRの変化がどのように予後と関連するのかは明らかではない。よって今回我々は、PH患者を対象にTRの重症度と予後との関連、ならびにPH治療によるTRの変化と予後との関連を評価した。, 国内会議
    口頭発表（一般）

  • 肺高血圧症における三尖弁閉鎖不全症と長期予後との関係
    向井 淳, 田中秀和, 佐野浩之, 横田 駿, 柴田奈緒, 高田裕基, 曽我文隆, 堂國久美子, 羽渓 優, 畑澤圭子, 松添弘樹, 久松恵理子, 松本賢亮, 中山和彦, 江本憲昭, 平田健一
    第125回日本循環器学会近畿地方会, 2018年06月, 日本語, 大阪, 国内会議
    口頭発表（一般）

  • 透析用シャントを閉鎖することで劇的な僧帽弁閉鎖不全症の改善が得られた一例
    羽渓 優, 田中 秀和, 須藤 麻貴子, 向井 淳, 曽我 文隆, 高田 裕基, 畑澤 圭子, 松添 弘樹, 松本 賢亮, 平田 健一
    日本超音波医学会 第91回学術集会, 2018年06月, 日本語, 神戸, 国内会議
    ポスター発表

  • 心房細動が僧帽弁形態に及ぼす影響と僧帽弁閉鎖不全症との関連について
    高田 裕基, 田中 秀和, 横田 駿, 柴田 奈緒, 向井 淳, 須藤 麻貴子, 曽我 文隆, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 久松 恵理子, 松本 賢亮, 平田 健一
    第125回日本循環器学会近畿地方会, 2018年06月, 日本語, 大阪, 国内会議
    口頭発表（一般）

  • 心筋症に対する負荷心エコー図の実際
    松本 賢亮
    日本超音波医学会 第91回学術集会, 2018年06月, 日本語, 日本超音波医学会, 神戸, 心不全患者に対するシンプルなストレスエコー法について概説した。, 国内会議
    シンポジウム・ワークショップパネル（指名）

  • 下肢陽圧負荷装置を用いた心不全患者に対する前負荷予備能評価と、その臨床応用可能性
    松本 賢亮, 楠瀬 賢也, 山田 博胤, 平田 健一
    日本超音波医学会 第91回学術集会, 2018年06月, 日本語, 日本超音波医学会, 神戸, 心不全患者に対する下肢陽圧負荷装置を用いたリスク層別化の試みを報告した。, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • Shortened Posterior Mitral Leaflet in Patients with Atrial Fibrillation and Significant Mitral Regurgitation
    Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Nao Shibata, Jun Mukai, Makiko Suto, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 29th Annual Scientific Session of the American Society of Echocardiography, 2018年06月, 英語, Nashville, 国際会議
    ポスター発表

  • Association of Tricuspid Regurgitation with Long-Term Outcome in Patients with Pulmonary Hypertension
    Jun Mukai, Hidekazu Tanaka, Hiroyuki Sano, Shun Yokota, Nao Shibata, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Kenichi Hirata
    The 29th Annual Scientific Session of the American Society of Echocardiography, 2018年06月, 英語, Nashville, 国際会議
    ポスター発表

  • 心房細動が僧帽弁形態に及ぼす影響と僧帽弁閉鎖不全症との関連について
    高田裕基, 田中秀和, 横田駿, 柴田奈緒, 向井淳, 須藤麻貴子, 曽我文隆, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 久松恵理子, 松本賢亮, 平田健一
    日本心エコー図学会 第29回学術集会, 2018年04月, 日本語, 盛岡, 国内会議
    口頭発表（一般）

  • 胸部打撲を契機に進行性に著明な低酸素血症を来した高齢男性の1例
    羽渓 優, 田中 秀和, 横田 駿, 柴田 奈緒, 須藤 麻貴子, 向井 淳, 曽我 文隆, 高田 裕基, 堂國 久美子, 畑澤 圭子, 松添 弘樹, 久松 恵理子, 松本 賢亮, 大北 裕, 平田 健一
    日本心エコー図学会 第29回学術集会, 2018年04月, 日本語, 盛岡, 国内会議
    ポスター発表

  • Shortened Posterior Mitral Leaflet in Patients with Atrial Fibrillation and Significant Mitral Regurgitation
    Hiroki Takada, Hidekazu Tanaka, Shun Yokota, Nao Shibata, Jun Mukai, Makiko Suto, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Eriko Hisamatsu, Kensuke Matsumoto, Ken-ichi Hirata
    第82回日本循環器学会学術集会, 2018年03月, 日本語, 日本循環器学会, 大阪, Background: The underlying mechanism of mitral regurgitation (MR) in atrial fibrillation (AF) is considered as isolated annulus dilation by left atrial (LA) remodeling. However, the association of mitral valve geometry with MR in AF patients remains unclear.Methods: We studied 96 AF patients with preserved left ventricular ejection fraction (LVEF)≥50% who underwent transthoraci, 国内会議
    ポスター発表

  • Comprehensive Assessment of Left Atrium for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients with Atrial Fibrillation
    Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Hiroyuki Sano, Eriko Hisamatsu, Kensuke Matsumoto, Ken-ichi Hirata
    第82回日本循環器学会学術集会, 2018年03月, 日本語, 日本循環器学会, 大阪, Background: Atrial fibrillation (AF) causes structural and electrical remodeling. Left atrial (LA) volume is a robust predictor for recurrence of AF after pulmonary vein isolation, however, recurrence of AF can be associated with multiple factors. Therefore, our objective was to test the hypothesis that comprehensive assessment of left atrium is better than the assessment of LA, 国内会議
    ポスター発表

  • Association of Body Fat Mass with Left Ventricular Myocardial Systolic Longitudinal Dysfunction in Type 2 Diabetes Mellitus
    羽渓優, 田中秀和, 望月泰秀, 須藤麻貴子, 柴田奈緒, 横田駿, 向井淳, 久松恵理子, 高田裕基, 曽我文隆, 堂國久美子, 畑澤圭子, 松添弘樹, 松本賢亮, 平田健一
    第82回日本循環器学会学術集会, 2018年03月, 日本語, 日本循環器学会, 大阪, Background: Left ventricular (LV) longitudinal myocardial systolic dysfunction (LVSD) has been identified in type 2 diabetes mellitus (T2DM) patients, and it should be considered the first marker of a preclinical form of DM-related cardiac dysfunction. Overweight has been postulated to contribute to the development of LVSD in T2DM patients, however, impact of amount of body fat, 国内会議
    口頭発表（一般）

  • 当院の劇症型心筋炎症例より、治療戦略と今後の課題を検討する
    久松 恵理子, 松本 賢亮, 柴田 奈緒, 横田 駿, 向井 淳, 須藤 麻貴子, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽溪 優, 畑澤 圭子, 松添 弘樹, 田中 秀和, 田中 裕史, 大北 裕, 平田 健一
    第46回人工心臓と補助循環懇話会学術集会, 2018年02月, 日本語, 人工心臓と補助循環懇話会, 熱海, 当院の劇症型心筋炎症例より、治療戦略と今後の課題を検討した, 国内会議
    ポスター発表

  • 成人動脈管開存症例における僧帽弁複合体及び左室形態的特徴の検討
    松本 賢亮, 須藤 麻貴子, 新家 俊郎, 平田 健一
    第20回日本成人先天性心疾患学会総会・学術集会, 2018年01月, 日本語, 日本成人先天性心疾患学会, 東京, 動脈管開存症に合併する僧帽弁閉鎖不全症について検討を行った。, 国内会議
    口頭発表（一般）

  • 成人先天性心疾患に対する負荷エコー
    松本 賢亮, 須藤 麻貴子, 平田 健一
    第20回日本成人先天性心疾患学会総会・学術集会, 2018年01月, 日本語, 日本成人先天性心疾患学会, 東京, 成人先天性心疾患に対する負荷心エコー図法をレクチャーした, 国内会議
    口頭発表（一般）

  • ファロー四徴症心内修復術後患者に対する下肢陽圧負荷装置を用いた前負荷予備能の検討
    須藤麻貴子, 松本賢亮, 城戸佐知子, 平田健一
    第20回日本成人先天性心疾患学会総会・学術集会, 2018年01月, 日本語, 日本成人先天性心疾患学会, 東京, 国内会議
    口頭発表（一般）

  • 動脈管開存と心房中隔欠損を合併した高度肺高血圧症の一成人例
    須藤麻貴子, 松本賢亮, 城戸 佐知子, 中山和彦, 田中秀和, 井上武, 大北裕, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 動脈管開存と心房中隔欠損を合併した高度肺高血圧症の一成人例を発表した, 国内会議
    口頭発表（一般）

  • 重症度の判別に苦慮した大動脈弁狭窄症の一例
    松添弘樹, 松本賢亮, 森俊平, 鳥羽敬義, 川森裕之, 下山真介, 田中秀和, 新家俊郎, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 症例は83歳女性。以前より大動脈弁狭窄症を指摘されていたが、一年前より合計3度の心不全入院を繰り返すようになり、精査加療目的で当院紹介となった。過去の心不全入院歴は高度大動脈弁狭窄症の経過として矛盾しないものの、大動脈弁位での圧較差に比して心エコー図での大動脈弁弁口面積および大動脈弁石灰化の程度は軽度であり、重症度に不一致を認めた。心臓CTによる任意多断面再構成（MPR）画像では、各交連部下に膜様組織の増生を認め、弁口部よりも左室流出路側に最狭窄部が存在していることが判明した。患者の全身状態から経カテーテル的大動脈弁置換術を施行し、その後心不全入院は消失した。弁交連部下の膜様組織による大動脈弁狭窄の様子を、心エコー図、心臓CT-MPR法にて同定しえたため画像とともに供覧する。, 国内会議
    口頭発表（一般）

  • 重症左心不全を合併したTAFRO症候群の一例
    羽渓 優, 田中 秀和, 下浦 広之, 大岡 順一, 佐野浩之, 郡山 恵子, 望月 泰秀, 松本 賢亮, 平田 健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 【背景】TAFRO症候群は、Castleman病の類縁疾患明とし提案され、原因なく急性あるいは亜急性に、全身浮腫（胸腹水）、発熱、骨繊維症、肝脾腫（Thrombocytopenia、Anasasrca、Fevere、Reticuin fibrosis、Organomegaly）の５徴を特徴とする疾患である。2010年には本邦からCastleman病とは異なる独立した疾患単位であることが明らかになった。今回我々はTAFRO症候群に重症心不全を呈し、集学的治療が奏功した症例を経験したので報告する。【症例】17歳男性。インフルエンザ罹患後から持続する発熱、頸部および腋窩リンパ節腫大、胸背部痛ならびに腰痛のために近医を救急受診された。精査では炎症反応の上昇、造影CTでは少量の腹水、肝脾腫を認めた。感染のフォーカスは特定できなかったが、細菌感染が疑われ、抗生剤, 国内会議
    口頭発表（一般）

  • 経カテーテル的大動脈弁植え込み術後に弁機能不全を呈した、先天性大動脈二尖弁の1例
    柴田奈緒, 松本賢亮, 森俊平, 鳥羽敬義, 下山真介, 田中秀和, 新家俊郎, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 症例は85歳女性。Type 0の先天性大動脈二尖弁に基づく高度の大動脈弁狭窄症に対し経カテーテル的大動脈弁植え込み術（TAVI）を施行した。術前の画像検査にて楕円形の弁輪、ならびにそれと直交する線状の弁接合部と非対称性の弁尖石灰化を認めた。解剖学的懸念はあったものの、患者背景を考慮し低侵襲のTAVIを選択した。術後の経食道心エコー図及び心臓CTでは、弁尖の石灰化に挟まれ弁尖先端部でステントが歪曲し、一枚の弁尖の可動性が消失していた。また、弁輪部でも石灰化によりステント拡張が障害され、中等度の弁周囲逆流を認めた。幸い血行動態的影響は乏しく、外来にて慎重に経過観察することとした。今回先天性大動脈二尖弁の特徴的な形態により人工弁が十分に拡張せず、弁機能不全を呈した1例を経験したので報告する。, 国内会議
    口頭発表（一般）

  • Ventriculo-arterial Coupling to Detect Heart Failure Symptoms in Patients with Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    Junichi Ooka, Hidekazu Tanaka, Kensuke Matsumoto, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Sano, Yasuhide Mochizuki, Ken-ichi Hirata
    American Heart Association scientific session 2017, 2017年11月, 英語, American Heart Association, Anaheim, CA, USA, 【Background】 Heart failure (HF) symptoms in severe aortic regurgitation (AR) often occur irrespective of AR severity and left ventricular ejection (LV) fraction (LVEF), and its precisely detection can be difficult. End-systolic ventricular elastance (Ees), the slope of the end-systolic pressure-volume relationship, is thought to be a load-independent index of myocardial contrac, 国際会議
    ポスター発表

  • Ventricular Interdependence by Means of Preload Stress Echocardiography in Patients with Pulmonary Hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Jun Mukai, Makiko Suto, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Kensuke Matsumoto, Kazuhiko Nakayama, Noriaki Emoto, Ken-ichi Hirata
    American Heart Association scientific session 2017, 2017年11月, 英語, American Heart Association, Anaheim, CA, USA, Background: Pulmonary hypertension (PH) is characterized by a marked and sustained elevation of pulmonary vascular resistance, leading to an increase in pulmonary artery pressure, and right ventricular (RV) failure. RV pressure overload in PH patients can affect left ventricular (LV) performance as a result of ventricular interdependence, however, association of functional rese, 国際会議
    ポスター発表

  • Comprehensive Assessment of Left Atrium for Predicting Recurrence of Atrial Fibrillation Following Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation
    Fumitaka Soga, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Makiko Suto, Hiroki Takada, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Junichi Ooka, Hiroyuki Sano, Eriko Hisamatsu, Kensuke Matsumoto, Ken-ichi Hirata
    American Heart Association scientific session 2017, 2017年11月, 英語, American Heart Association, Anaheim, CA, USA, Background: Atrial fibrillation (AF) causes structural and electrical remodeling, including atrial enlargement and fibrosis. Left atrial (LA) volume is a robust predictor for recurrence of AF after pulmonary vein isolation, however, recurrence of AF can be associated with multiple factors. Therefore, our objective was to test the hypothesis that comprehensive assessment of left, 国際会議
    ポスター発表

  • 2型糖尿病患者の脂肪量と潜在的心機能障害の関連性および予測因子
    羽渓優, 田中秀和, 望月泰秀, 須藤麻貴子, 柴田奈緒, 横田駿, 向井淳, 久松恵理子, 高田裕基, 曽我文隆, 堂國久美子, 畑澤圭子, 松添弘樹, 松本賢亮, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 【背景】糖尿病では左室長軸方向の収縮能低下が左室拡張能障害よりも早期に起こることが知られている。また、肥満は糖尿病性心筋障害の増悪因子であると報告されているが、脂肪量との関連は明らかではない。【方法】冠動脈疾患がなく、左室駆出率が保持された73人糖尿病患者を対象とした（女性37人）。左室長軸方向の収縮能はglobal longitudinal strain (GLS)で評価した（異常値：<18%）。体脂肪量は体組成分析装置で測定し、体表面積で補正した（Body Fat Index：BFI）。【結果】単変量解析ではbody mass indexとBFIがGLS<18％と関連していたが、多変量解析ではBFIのみが関連していた。また、BFIとGLSは女性では有意な逆相関を認めたが(r=-0.49, p=0.002)、男性では認められなかった(r=-0.30, 国内会議
    口頭発表（一般）

  • 肺高血圧症患者における下肢陽圧負荷心エコー図検査の有用性
    佐野浩之, 田中秀和, 元地由樹, 向井淳, 須藤麻貴子, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 大岡順一, 松本賢亮, 中山和彦, 江本憲昭, 平田健一
    第65回日本心臓病学会学術集会, 2017年09月, 日本語, 日本心臓病学会, 大阪, 【目的】肺高血圧症（PH）患者において、下肢陽圧負荷を用いたpreload stress心エコー図検査を行い、その有用性を検討すること。【方法】対象はPH患者43例（肺動脈性肺高血圧症：24例、慢性肺血栓塞栓性肺高血圧症：19例）とPH群と年齢ならびに性別をマッチさせたと正常コントロール17例とした。全例に安静時ならびに下肢陽圧負荷心エコー図検査を行った（DR. Medomer DM-5000EX, Medo Industries CO., Ltd., Tokyo Japan）。右室収縮能は2次元スペックルトラッキング法を用いて、右室自由壁3領域のpeak longitudinal strainの平均値として評価し（RV free-wall strain）、右室収縮予備能は、下肢陽圧負荷によるRV free-wall strainの相対的変化率とした, 国内会議
    ポスター発表

  • 外科的心房中隔欠損修復後44年後に経皮的心房中隔欠損閉鎖術を施行した高齢女性の一例
    松添弘樹, 田中秀和, 須藤麻貴子, 向井淳, 高田裕基, 曽我文隆, 羽渓優, 畑澤圭子, 松本賢亮, 平田健一
    第44回日本超音波医学会関西地方会学術集会, 2017年09月, 日本語, 日本超音波医学会, 大阪, 症例は75歳女性。44年前に心房中隔欠損孔に対し外科的にパッチ閉鎖術が施行されている。労作時息切れならびに心房中隔欠損症の再発のために当科に紹介となった。経食道心エコー図検査にてValsalva洞付近の心房中隔に外科的修復に使用されたパッチと思われる高輝度エコーと、その下後側に5.9mm×9.1mmの欠損とそれに付随した左右シャント血流を認めた。本症例に対して経皮的心房中隔欠損閉鎖術を施行したが、外科的修復術後の残存欠損孔に対し、また44年前に使用されたパッチの近傍にも関わらず経皮的にデバイス閉鎖した症例は極めて稀であるため報告する。, 国内会議
    口頭発表（一般）

  • The assessment of contractile reserve and diastolic reserve during non-invasive preload stress echocardiography contributes to the risk stratification for patients with heart failure
    松本賢亮, 田中秀和, 山田博胤, 向井淳, 須藤麻貴子, 高田裕基, 曽我文隆, 羽渓優, 松添弘樹, 畑澤圭子, 下浦広之, 大岡順一, 佐野浩之, 平田健一
    ESC Congress 2017, 2017年08月, 英語, European Society of Cardiology, Barcelona, Spain, I presented the clinical utility of leg positive pressure echocardiography for the assessment of patients prognosis., 国際会議
    口頭発表（一般）

  • 逆Rivero-Carvallo徴候をMRIにて証明したStraight Back Syndromeの一例
    須藤麻貴子, 森俊平, 西井達矢, 伊澤有, 下山真介, 小西弘樹, 松本賢亮, 田中秀和, 平田健一
    第123回日本循環器学会近畿地方会, 2017年06月, 日本語, 日本循環器学会, 大阪, 国内会議
    口頭発表（一般）

  • 悪性リンパ腫の患者における抗癌剤投与後の左室収縮能低下を予測する因子の検討
    畑澤圭子, 田中秀和, 野中顕子, 須藤麻貴子, 向井淳, 久松恵理子, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 望月泰秀, 漁 恵子, 松本賢亮, 平田健一
    第123回日本循環器学会近畿地方会, 2017年06月, 日本語, 日本循環器学会, 大阪, 国内会議
    口頭発表（一般）

  • Predictor of left ventricular systolic dysfunction in Patients malignant lymphoma after receiving anthracycline
    Keiko Hatazawa, Hidekazu Tanaka, Akiko Nonaka, Makiko Suto, Jun Mukai, Eriko Hisamatsu, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    The 28th Annual Scientific Session of the American Society of Echocardiography, 2017年06月, 英語, American Society of Echocardiography, Baltimore, USA, 国際会議
    ポスター発表

  • Left Ventricular Dispersion as a Parameter for Increase Left Ventricular Stroke Volume in Patients with Atrial Septal Defect following Transcatheter Closure
    Yutaka Hatani, Hidekazu Tanaka, Makiko Suto, Jun Mukai, Eriko Hisamatsu, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    The 28th Annual Scientific Session of the American Society of Echocardiography, 2017年06月, 英語, American Society of Echocardiography, Baltimore, USA, Background: Atrial septal defect (ASD) is one of the most common forms of congenital heart disease in adults. In addition, the left-to-right shunt causes inadequate left ventricular (LV) diastolic filling, and reduced LV end-diastolic volume by right ventricular (RV) dilatation, leading left-sided heart failure for insufficient LV stroke volume (LVSV) to maintain blood flow to, 国際会議
    ポスター発表

  • Impact of Obesity on Left Ventricular Longitudinal Function in Diabetes Mellitus
    Makiko Suto, Hidekazu Tanaka, Yasuhide Mochizuki, Jun Mukai, Eriko Hisamatsu, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    The 28th Annual Scientific Session of the American Society of Echocardiography, 2017年06月, 英語, American Society of Echocardiography, Baltimore, USA, 国際会議
    ポスター発表

  • Bi-ventricular Interaction in Patients with Atrial Septal Defect Following Transcatheter Closure
    Yutaka Hatani, Hidekazu Tanaka, Makiko Suto, Jun Mukai, Eriko Hisamatsu, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    The 28th Annual Scientific Session of the American Society of Echocardiography, 2017年06月, 英語, American Society of Echocardiography, Baltimore, USA, Background: Atrial septal defect (ASD) causes chronic volume overload on right-sided heart, resulting in right-sided heart failure. Transcatheter closure of ASD currently is widely considered to be the first-choice therapeutic option, but bi-ventricular interaction in patients with ASD following transcatheter closure remains uncertain.Methods: We studied 70 ASD patients who und, 国際会議
    ポスター発表

  • 成人先天性心疾患診療における心エコー図検査の実際
    松本賢亮, 須藤麻貴子, 平田健一
    日本超音波医学会第90回学術集会, 2017年05月, 日本語, 日本超音波医学会, 宇都宮, 成人先天性心疾患領域における心エコー図検査法のコツに関して解説した, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 初心者が陥る左室収縮能評価のピットフォール
    松本賢亮
    日本超音波医学会第90回学術集会, 2017年05月, 日本語, 日本超音波医学会, 宇都宮, 初心者が陥りがちな心収縮能評価法の落とし穴について教育講演を行った。, 国内会議
    公開講演，セミナー，チュートリアル，講習，講義等

  • 重症左心不全を合併したTAFRO症候群の一例
    羽渓 優, 田中 秀和, 下浦 広之, 大岡 順一, 佐野 浩之, 郡山 恵子, 望月 泰秀, 松本 賢亮, 平田 健一
    日本超音波医学会第90回学術集会, 2017年05月, 日本語, 日本超音波医学会, 宇都宮, 【背景】TAFRO症候群は、Castleman病の類縁疾患明とし提案され、原因なく急性あるいは亜急性に、全身浮腫（胸腹水）、発熱、骨繊維症、肝脾腫（Thrombocytopenia、Anasasrca、Fevere、Reticuin fibrosis、Organomegaly）の５徴を特徴とする疾患である。2010年には本邦からCastleman病とは異なる独立した疾患単位であることが明らかになった。今回我々はTAFRO症候群に重症心不全を呈し、集学的治療が奏功した症例を経験したので報告する。【症例】17歳男性。インフルエンザ罹患後から持続する発熱、頸部および腋窩リンパ節腫大、胸背部痛ならびに腰痛のために近医を救急受診された。精査では炎症反応の上昇、造影CTでは少量の腹水、肝脾腫を認めた。感染のフォーカスは特定できなかったが、細菌感染が疑われ、抗生剤, 国内会議
    口頭発表（一般）

  • 急性前負荷増大負荷エコーを用いた収縮不全心における予後層別化の試み
    松本賢亮, 山田博胤
    日本超音波医学会第90回学術集会, 2017年05月, 日本語, 日本超音波医学会, 宇都宮, 下肢陽圧負荷装置を用いた心エコー図検査を行うことにより、収縮能の低下した心不全患者の予後予測能を検討し発表した。, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 悪性リンパ腫の患者における抗癌剤投与後の左室収縮能低下を予測する因子の検討
    畑澤圭子, 田中秀和, 野中顕子, 須藤麻貴子, 向井淳, 久松恵理子, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 望月泰秀, 漁 恵子, 松本賢亮, 平田健一
    日本超音波医学会第90回学術集会, 2017年05月, 日本語, 日本超音波医学会, 宇都宮, 国内会議
    口頭発表（基調）

  • 肺高血圧患者における治療後の右室reverse remodelingを予測する因子の検討
    佐野浩之, 田中秀和, 元地由樹, 須藤麻貴子, 向井淳, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 大岡順一, 下浦広之, 郡山恵子, 松本賢亮, 江本憲昭, 平田健一
    第28回日本心エコー図学会学術集会, 2017年04月, 日本語, 日本心エコー図学会, 名古屋, 肺高血圧患者における治療後の右室reverse remodelingを予測にはrerative wall thicknessが有用であった, 国内会議
    口頭発表（一般）

  • 糖尿病患者における肥満が左室長軸方向の収縮能ならびに左室拡張能に与える影響について
    須藤麻貴子, 田中秀和, 望月泰秀, 向井淳, 久松恵理子, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 郡山恵子, 松本賢亮, 平田健一
    第28回日本心エコー図学会学術集会, 2017年04月, 日本語, 日本心エコー図学会, 名古屋, 国内会議
    口頭発表（一般）

  • 糖尿病患者における肥満が左室長軸方向の収縮能に与える影響について
    須藤 麻貴子, 田中 秀和, 望月 泰秀, 向井 淳, 久松 恵理子, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 佐野 浩之, 下浦 広之, 郡山 恵子, 松本 賢亮, 平田 健一
    第81回日本循環器学会学術集会, 2017年03月, 日本語, 日本循環器学会, 金沢, Obesity has a greater effect on LV longitudinal function in patients with DM over non-DM healthy subjects. The strict control of obesity in DM patients may be associated with the prevention of HFpEF., 国内会議
    ポスター発表

  • Ventriculo-arterial Coupling for Detecting Heart Failure Symptoms in Patients with Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    大岡 順一, 田中 秀和, 松本 賢亮, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 望月 康秀, 郡山 恵子, 平田 健一
    第81回日本循環器学会学術集会, 2017年03月, 日本語, 日本循環器学会, 金沢, また、左室拡張能障害と密接に関連する左室の心筋性状として、左室長軸方向の心筋収縮能が重要である。これは2次元スペックルトラッキング法を用いて、標準的な左室心尖部3断面の18領域の長軸方向の最大ストレイン値を平均することによって算出できる（Global Longitudinal Strain：GLS）。GLSは左室駆出率が保持された心不全（HFpEF）では有意に低下していることが報告されており、HFpEFではGLSが低下しているほど予後が悪いとも報告されている。, 国内会議
    口頭発表（一般）

  • Utility of Ventriculo-arterial Coupling to Predict Post-operative Left Ventricular Dysfunction in Patients with Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    大岡 順一, 田中 秀和, 松本 賢亮, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 望月 康秀, 郡山 恵子, 平田 健一
    第81回日本循環器学会学術集会, 2017年03月, 日本語, 日本循環器学会, 金沢, 本セッションでは心エコー図法による左室拡張能評価のtips and tricks、ならびにGLSの有用性を講演する。, 国内会議
    ポスター発表

  • Significant prognostic values of acute preload stress echocardiography by using leg-positive pressure maneuver in patients with severe aortic stenosis
    Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Ken-ichi Hirata
    第81回日本循環器学会学術集会, 2017年03月, 日本語, 日本循環器学会, 金沢, Aims: To evaluate the ability to utilize the Frank-Starling mechanism without significant increase in left ventricular (LV) filling pressure in response to leg-positive pressure (LPP) maneuver could provide prognostic capability for patients with aortic stenosis (AS).Methods:We prospectively recruited 54 patients with severe AS. LV stroke volume index (SVi) was assessed by puls, 国内会議
    ポスター発表

  • Serum Phosphate Level Predicts Total Aortic Calcification Burden in Patients with Severe Aortic Stenosis
    Daisuke Terashita, Shumpei Mori, Natsuko Tahara, Yu Izawa, Takayoshi Toba, Sei Fujiwara, Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiromasa Otake, Toshiro Shinke, Tatsuya Nishii, Atsushi Kono, Ken-ichi Hirata
    第84回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議
    口頭発表（基調）

  • Comparison of Left Ventricular Outflow Tract Area Estimated by Transthoracic Echocardiography and Measured by Computed Tomography
    Yu Izawa, Shumpei Mori, Natsuko Tahara, Daisuke Terashita, Takayoshi Toba, Sei Fujiwara, Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiromasa Otake, Toshiro Shinke, Tatsuya Nishii, Atsushi Kono, Ken-ichi Hirata
    第81回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議
    ポスター発表

  • Association of left ventricular function with stages of cancer and concomitant diseases in patients with lymphoma and preserved ejection fraction
    畑澤 圭子, 田中 秀和, 野中 顕子, 須藤 麻貴子, 向井 淳, 久松 恵理子, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽渓 優, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 望月 泰秀, 郡山 恵子, 松本 賢亮, 平田 健一
    第81回日本循環器学会学術集会, 2017年03月, 日本語, 日本循環器学会, 金沢, Aims: Our aim was to test the hypothesis that cancer-related left ventricular (LV) damage worsened as cancer progresses. We also evaluated if LV dysfunction by cardiotoxicity of anthracycline was associated with stages of cancer and concomitant diseases.Methods: We studied 52 patients with lymphoma and preserved LV ejection fraction (LVEF) (all≥50%) referred for anthracycline c, 国内会議
    ポスター発表

  • Aortic Valve Calcification Density Predicts the Hemodynamic Severity of Aortic Stenosis Independently of Aortic Valve Area
    Takayoshi Toba, Shumpei Mori, Natsuko Tahara, Yu Izawa, Daisuke Terashita, Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiromasa Otake, Sei Fujiwara, Toshiro Shinke, Tatsuya Nishii, Atsushi Kono, Ken-ichi Hirata
    第85回日本循環器学会学術大会, 2017年03月, 英語, 日本循環器学会, 金沢, 国内会議
    ポスター発表

  • 透視では確認できないシリコン被膜が残存し、2回のリード抜去を要した後に開胸にて摘出となったデバイス感染の一例
    市堀 博俊, 福沢 公二, 木内 邦彦, 小西 弘樹, 兵庫 聖大, 今田 宙志, 黒瀬 潤, 秋田 朋己, 末廣 英也, 永松 裕一, 松本 賢亮, 森 俊平, 平田 健一, 西井 達矢, 山田 貴之
    第9回植込みデバイス関連冬季大会, 2017年02月, 日本語, 日本不整脈心電学会, 大阪, 国内会議
    口頭発表（一般）

  • 両大血管右室起始症、上下心、二心腔修復術後遠隔期に心室頻拍と左室流出路狭窄が出現し、治療法選択に迷った1例
    松本 賢亮, 城戸 佐知子, 須藤 麻貴子, 郡山 恵子, 福沢 公二, 山口 眞弘, 伊藤 光哲, 山城 荒平, 平田 健一
    第19回日本成人先天性心疾患学会総会・学術集会, 2017年01月, 日本語, 日本成人先天性心疾患学会, 津, DORVの心修復術後に心室頻拍を生じた36歳男性症例。, 国内会議
    ポスター発表

  • 青年期に急速な増悪を認めた肥大型心筋症の2例
    須藤 麻貴子, 松本 賢亮, 田中 秀和, 井上 武, 大北 裕, 城戸 佐知子, 平田 健一
    第19回日本成人先天性心疾患学会総会・学術集会, 2017年01月, 日本語, 日本成人先天性心疾患学会, 津, 肥大型心筋症（HCM）において、左室肥大の進行やそれに伴う左室流出路狭窄の出現は心不全症状の原因となり、また突然死の危険因子となりうるため注意深い経過観察と適切な時期での治療介入が必要となる。今回青年期に急速な左室肥大の進行を認め、手術加療を要した興味深いHCMの2例を経験したため報告する。, 国内会議
    ポスター発表

  • 透視では確認できないシリコン被膜が残存し、2回のリード抜去を要した後に開胸にて摘出となったデバイス感染の一例
    市堀 博俊, 福沢 公二, 木内 邦彦, 小西 弘樹, 兵庫 聖大, 今田 宙志, 黒瀬 潤, 秋田 朋己, 末廣 英也, 永松 裕一, 松本 賢亮, 森 俊平, 平田 健一, 西井 達矢, 山田 貴之
    第122回日本循環器学会近畿地方会, 2016年11月, 日本語, 日本循環器学会近畿支部, 大阪, 国内会議
    口頭発表（一般）

  • 高度大動脈弁狭窄症患者における前負荷予備能の検討
    松添 弘樹, 松本 賢亮, 田中 秀和, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 大岡 順一, 下浦 広之, 佐野 浩之, 望月 泰秀, 郡山 恵子, 平田 健一
    第122回日本循環器学会近畿地方会, 2016年11月, 日本語, 日本循環器学会近畿支部, 大阪, 【目的】下肢陽圧負荷法を用いた急性前負荷増大負荷心エコー図検査により、大動脈弁狭窄症（AS）患者のリスク層別化を行うこと。【方法】対象は高度AS患者54例。心臓死および心不全入院を複合エンドポイントとした。【結果】経過中9例が心事故を認めた。非心事故群では前負荷増大負荷に対しE/e’の上昇なしに一回拍出量の有意な増大を認めたが(SVi 43±9 to 49±10ml/m2, p<0.001)、心事故群ではSViの増大反応を認めず、著明なE/e’の上昇を認めた(25±7 to 32±8, p<0.01)。また中央値で患者群を2群に分けると、前負荷増大負荷によりE/e’の上昇を認めた群およびSViの増加が認められない群においてそれぞれ有意に心事故が多く認められた。【結論】前負荷予備能および拡張予備能の評価はAS患者のリスク層別化に有用である。, 国内会議
    口頭発表（一般）

  • Ventriculo-arterial Coupling to Detect Heart Failure Symptoms in Patients with Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    大岡 順一, 田中 秀和, 松本 賢亮, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 望月 康秀, 郡山 恵子, 平田 健一
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Background: Identification of heart failure (HF) symptoms in patients with severe aortic regurgitation (AR) and preserved left ventricular (LV) ejection fraction (EF) isclinically important, but assessment of HF symptoms is challenging. In addition, HF symptoms in severe AR patients often occur irrespective of AR severity and LVEF, andits precisely detection can be difficult. E, 国際会議
    ポスター発表

  • Utility of End-systolic Ventricular Elastance for Predicting Post-operative Left Ventricular Dysfunction in Patients with Severe Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
    大岡 順一, 田中 秀和, 松本 賢亮, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 望月 康秀, 郡山 恵子, 平田 健一
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Background: Patients with chronic aortic regurgitation (AR) suffer from volume and pressure overload. Post-operative left ventricular (LV) systolic function is an important determinant of post-operative prognosis, but its detection is rather difficult. Although the LV ejection fraction (LVEF) is the most widely used measurement of LV function upon which surgical risk assessment, 国際会議
    ポスター発表

  • Significant prognostic values of acute preload stress echocardiography by using leg-positive pressure maneuver in patients with severe aortic stenosis
    Hiroki Matsuzoe, Kensuke Matsumoto, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Ken-ichi. Hirata
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Introduction: Recently, leg-positive pressure (LPP) maneuver, using customized air-bags inflated both lower limbs to maintain a constant loading pressure (90 mmHg for 5 minutes), is reported to be able to apply acute preload stress non-invasively without significant change in either heart rate or blood pressure. Hypothesis: We hypothesized the ability to utilize the Frank-Starl, 国際会議
    ポスター発表

  • Predictor of right ventricular reverse remodeling after treatment in patients with pulmonary hypertension
    Hiroyuki Sano, Hidekazu Tanaka, Yoshiki Motoji, Yuko Fukuda, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Keiko Ryo-Koriyama, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Right ventricular relative wall thickness(RV-RWT) could predict mid-term RV reverse remodeling after treatment in PH patients, and was associated with long-term outcomes. Our findings may have clinical implications for better management of PH patients., 国際会議
    ポスター発表

  • Impact of Left Ventricular Longitudinal Functional Mechanics on the Progression of Diastolic Function in Diabetes Mellitus
    Yasuhide Mochizuki, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Background: Left ventricular (LV) diastolic dysfunction was identified as the earliest functional alteration in the course of diabetic cardiomyopathy, and also established it as an important prognostic marker in patients with diabetes mellitus (DM). Furthermore, LV longitudinal systolic dysfunction was closely associated with diabetic cardiomyopathy in DM patients with preserve, 国際会議
    ポスター発表

  • Impact of Albuminuria on Left Atrial Function Mediated by Left Ventricular Longitudinal Function in Patients with Diabetic Mellitus
    Yasuhide Mochizuki, Hidekazu Tanaka, Hiroki Takada, Fumitaka Soga, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Keiko Ryo-Koriyama, Kensuke Matsumoto, Ken-ichi Hirata
    American Heart Association Scientific Sessions 2016, 2016年11月, 英語, American Heart Association, New Orleans, USA, Background: Diabetic nephropathy is independently associated with left ventricle (LV) longitudinal systolic myocardial dysfunction in asymptomatic diabetes mellitus (DM) patients with preserved LV ejection fraction (LVEF). However, the impact of diabetic nephropathy on left atrial (LA) function remains unknown.Methods: We studied 198 asymptomatic DM patients, all of whom had pr, 国際会議
    ポスター発表

  • 他のアンジオテンシンII受容体拮抗薬からオルメサルタンへの変更が心不全患者の左室肥大に与える効果
    下浦 広之, 田中 秀和, 松本 賢亮, 大岡 順一, 佐野 浩之, 望月 泰秀, 郡山 恵子, 平田 健一
    第20回日本心不全学会学術集会, 2016年10月, 日本語, 日本心不全学会, 札幌, Background: Left ventricular (LV) hypertrophy (LVH) is an independent cardiovascular risk factor for heart failure (HF) patients. The renin-angiotensin system plays a key role in LVH, and since olmesartan increases plasma angiotensin-(1-7) through an incr, 国内会議
    ポスター発表

  • 肺高血圧症患者における治療後の右室reverse remodelingを予測する因子の検討
    佐野 浩之, 田中 秀和, 福田 優子, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 下浦 広之, 佐和 琢磨, 望月泰秀, 郡山恵子, 松本 賢亮, 江本 憲昭, 平田 健一
    第64回日本心臓病学会学術集会, 2016年09月, 日本語, 日本心臓病学会, 東京, 【背景】肺高血圧患者の右室収縮能は重要な予後予測因子であり、治療後中期の右室のreverse remodelingが長期予後と密接に関連していることを最近我々は報告した。しかし、肺高血圧患者における治療後の右室reverse remodelingを規定する予測因子は明らかではない。【目的】肺高血圧患者において、治療後の右室reverse remodelingを予測する因子を検討し、その因子が長期予後予測に有用か評価すること。【方法】対象は肺高血圧患者54例。治療前の安静時平均肺動脈圧は38±10mmHgであった。心エコー図検査は治療前と治療後10.2±9.6ヵ月後に施行した。右室のreverse remodelingの判定は右室収縮末期面積の15%以上の相対的な減少と定義した。長期予後予測の検討は、エンドポイントを死亡または右心不全による入院とし、5, 国内会議
    ポスター発表

  • 症候性大動脈弁狭窄症患者における前負荷予備能の検討
    松添弘樹, 松本賢亮, 田中秀和, 高田裕基, 曽我文隆, 羽渓優, 畑澤圭子, 大岡順一, 下浦広之, 佐野浩之, 佐和琢磨, 望月泰秀, 郡山恵子, 平田健一
    第64回日本心臓病学会学術集会, 2016年09月, 日本語, 日本心臓病学会, 東京, 【背景】 症候性の大動脈弁狭窄症は一般に早期の外科的介入が必要であるとされているが、現在のところ心血管事故に対するリスクの層別化についての明確な指標はない。【目的】前負荷予備能の評価は、症候性の大動脈弁狭窄患者の管理において付加的な予後情報を与える可能性があるとの仮説のもと、下肢陽圧負荷心エコー図法を用いたpreload stress心エコー図検査にて、大動脈弁狭窄症患者のリスクを層別化すること。【方法】症候性の大動脈弁狭窄症患者35例（平均年齢:80±8歳, 大動脈弁弁口面積係数: 0.42±0.12cm2/m2 、左室駆出率: 68±12%）を対象とした。通常の心エコー図検査とともに、下肢陽圧負荷によるpreload stressエコー図検査を施行。一次エンドポイントを心臓死または症状増悪による再入院、複合エンドポイントを大動脈弁置換術と心臓死ま, 国内会議
    口頭発表（一般）

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw
    Akashi M, Hashikawa K, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto K, Sakakibara A, Hasegawa T, Minamikawa T, Furudoi S, Komori T
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • 2次元スペックルトラッキング法でみた左室-左房連関に及ぼす糖尿病性腎症の影響
    望月泰秀, 田中秀和, 高田裕基, 曽我文隆, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 大岡順一, 佐野浩之, 下浦広之, 郡山恵子, 松本賢亮, 平田健一
    第64回日本心臓病学会学術集会, 2016年09月, 日本語, 日本心臓病学会, 東京, 【背景】糖尿病性腎症を有する患者では左室駆出率が保持されていても左室長軸方向への収縮が低下している。しかしながら、左房機能と腎症の関係性のみならず、その関係性に左室長軸方向への収縮能を介した知見はない。【方法】虚血性心疾患が否定され、左室駆出率が保持された（≥50%）糖尿病患者連続198例と年齢、性別をマッチさせた健常者60名を対象とした。2次元スペックルトラッキング法を用いて、心尖部3断面18領域モデルのpeak longitudinal strainの平均値をGLSとして算出した。また、左房の収縮期最大strainをLAS-s (reservoir function)、拡張後期の左房収縮strainをLAS-a (contractile function)と定義し、心尖部2腔像、４腔像での平均値として算出した。24時間蓄尿での尿中アルブミン排泄率, 国内会議
    ポスター発表

  • Significant prognostic impact of the preload reserve and diastolic reserve during acute preload stress echocardiography using leg-positive pressure manoeuver in patients with heart failure
    Kensuke Matsumoto, H. Tanaka, H. Takada, F. Soga, Y. Hatani, H. Matsuzoe, K. Hatazawa, H. Shimoura, J. Ooka, H. Sano, T. Sawa, Y. Mochizuki, K. Ryo-Koriyama, K-I. Hirata
    ESC Congress 2016, 2016年08月, 英語, European Society of Cardiology, ローマ, イタリア, Preload reserve as well as diastolic reserve during acute preload stress echocardiography is important determinants of cardiovascular outcome for patients with heart failure, 国際会議
    ポスター発表

  • 心不全患者におけるオルメサルタンの左室肥大退縮効果についての検討
    下浦 広之, 田中 秀和, 松本 賢亮, 望月 泰秀, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 佐野 浩之, 佐和 琢磨, 郡山 恵子, 平田 健一
    第121回日本循環器学会近畿地方会, 2016年07月, 日本語, 日本循環器学会近畿支部, 京都, 背景：アンジオテンシンII受容体拮抗薬（ARB）は心肥大退縮効果を有しているが、中でもオルメサルタンはアルドステロンブレイクスルーを起こしにくいことが報告されており、より強力な心肥大抑制効果が期待される。方法：他剤ARBをすでに１年以上投与された慢性心不全患者59例を対象とし、オルメサルタンに変更後6ヶ月後の心肥大退縮効果、BNPの変化を検証した。結果：血圧、心拍数に有意な変化を認めなかったが、左室心筋重量係数は有意に減少し（119±38 g/m2 vs. 110±24 g/m2、p=0.007）、BNPは改善傾向であった（52pg/mL vs. 40pg/mL、p=0.2）。結論：オルメサルタンはARBの中で、より左室肥大の退縮に寄与する可能性が示唆された。, 国内会議
    口頭発表（一般）

  • 循環器(1)ワークショップ 拡張型心筋症に対するドブタミン負荷心エコー法での評価
    下浦 広之, 田中 秀和, 松本 賢亮, 望月 泰秀, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 佐野 浩之, 佐和 琢磨, 郡山 恵子, 平田 健一
    第121回日本循環器学会近畿地方会, 2016年07月, 日本語, 日本循環器学会近畿支部, 京都, 背景：アンジオテンシンII受容体拮抗薬（ARB）は心肥大退縮効果を有しているが、中でもオルメサルタンはアルドステロンブレイクスルーを起こしにくいことが報告されており、より強力な心肥大抑制効果が期待される。方法：他剤ARBをすでに１年以上投与された慢性心不全患者59例を対象とし、オルメサルタンに変更後6ヶ月後の心肥大退縮効果、BNPの変化を検証した。結果：血圧、心拍数に有意な変化を認めなかったが、左室心筋重量係数は有意に減少し（119±38 g/m2 vs. 110±24 g/m2、p=0.007）、BNPは改善傾向であった（52pg/mL vs. 40pg/mL、p=0.2）。結論：オルメサルタンはARBの中で、より左室肥大の退縮に寄与する可能性が示唆された。, 国内会議
    口頭発表（一般）

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用と心拍出量増加について
    羽渓優, 田中秀和, 高田裕基, 曽我文隆, 畑澤圭子, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 郡山恵子, 松本賢亮, 大竹寛雅, 新家俊郎, 平田健一
    第121回日本循環器学会近畿地方会, 2016年07月, 日本語, 日本循環器学会近畿支部, 京都, 【目的】経皮的心房中隔欠損閉鎖術（ASO）後の両心室の変化と、左室の心拍出量増加に寄与する因子が何であるかを検討すること。【方法】対象はASOが施行された心房中隔欠損症70例。術前および術後3ヶ月に左室心筋機能の評価として、global longitudinal strainとLV dispersion（左室収縮のばらつき）を、右室収縮能指標としてRV free-wall strainを算出した。【結果】ASO後にRV free-wall strainは有意に低下し、LV dispersionは有意に低下した。多変量解析ではRV free-wall strainの変化率とLV dispersionの変化率が、ASO後の左室心拍出量の増加に寄与する独立した規定因子であった。【結語】LV dispersionならびにRV free-wall strain, 国内会議
    口頭発表（一般）

  • Clinical investigation of oral vascular malformations by multiple photocoagulation with Nd:YAG lazer
    Kitayama M, Suzuki H, Matsumoto K, Matsuo K, Komori S, Enomoto Y, Asai T, Komori T
    The 15th Congress of the World Federation for Laser Dentistry, 2016年07月, 日本語, 日本レーザー歯学会, 名古屋, 国内会議
    ポスター発表

  • Clinical investigation of carbon dioxide laser treatment for lingual leukoplakia
    Matsuo K, Suzuki H, Yamashita J, Komori S, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Takeuti J, Matsumoto K, Komori T
    The 15th Congress of the World Federation for Laser Dentistry, 2016年07月, 日本語, 日本レーザー歯学会, 名古屋, 国内会議
    ポスター発表

  • 外科的心筋切除術が奏功した、Noonan症候群に合併した両心室閉塞性肥大型心筋症の1例
    高田 裕基, 松本 賢亮, 田中 秀和, 平田 健一
    第212回日本内科学会近畿地方会, 2016年06月, 日本語, 日本内科学会, 大阪, 【症例】22歳男性【主訴】胸部不快感、呼吸困難感【現病歴】生後9か月時に心雑音を指摘され、肥大型心筋症と診断。その後の遺伝子診断でRAF1遺伝子変異が確認され、Noonan症候群と確定診断された。当初薬物療法と運動制限により自覚症状なく経過していたが、2014年末頃より胸部不快感、呼吸困難感を自覚するようになった。心エコー図検査では心室中隔厚42mm、左室後壁厚30mmと著明な求心性左室肥大を認め、それに伴い心尖部、心室中部、および左室流出路にそれぞれ有意な動的閉塞を認めた。また、右室自由壁の肥大に伴う著明な右室内閉塞も併存していた。両心室の閉塞性肥大型心筋症による前方駆出の制限が症状の原因であると判断。これに対し、心尖部から流出路にかけての左室心筋切除、および右室流出路の心筋切除術を施行した。術後心内腔の拡大を認め、両心室における動的閉塞は解除され, 国内会議
    口頭発表（一般）

  • 循環器シンポジウム5：心機能評価の新たな展開Non-invasive Single-beat法を用いた心室血管連関の定量的評価とその臨床応用
    松本賢亮, 田中秀和, 平田健一
    日本超音波医学会第89回学術集会, 2016年05月, 日本語, 日本超音波医学会, 京都, 非侵襲的エコー評価による心不全患者における心血管連環の評価の有用性につき述べた。, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 循環器(1)ワークショップ 拡張型心筋症に対するドブタミン負荷心エコー法での評価
    松本 賢亮
    日本超音波医学会第89回学術集会, 2016年05月, 日本語, 日本超音波医学会, 京都, 拡張型心筋症に対するドブタミン負荷心エコー図評価の有用性につき概説した, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用について
    羽渓優, 田中秀和, 佐和琢磨, 下浦広之, 大岡順一, 佐野浩之, 望月泰秀, 郡山恵子, 松本賢亮, 平田健一
    第89回日本超音波医学会学術集会, 2016年05月, 日本語, 日本超音波医学会, 京都, 【背景】近年高齢者の心房中隔欠損（ASD）患者に対する、経皮的心房中隔欠損閉鎖術（ASO）は増加傾向にある。ASO後の右心負荷の軽減や左室の心拍出量の増大が、ASD患者の症状ならびに予後の改善に関連していると考えられている。しかしながら、ASO前後における両心室間の相互関係や、ASO後の左室心拍出量の増加に寄与する因子については十分に検討されていない。【目的】ASO後の両心室の変化と、左室の心拍出量増加に寄与する因子が何であるかを検討すること。【方法】ASOを施行されたASD患者70名を対象とした（平均年齢：57±16歳、女性：42例、左室駆出率：72±8%）。全例術前および術後3ヶ月に心臓超音波検査を施行した。左室心筋機能の評価として、2次元スペックルトラッキング法を用いて、左室18領域のpeak strain値の平均であるGlobal longi, 国内会議
    口頭発表（一般）

  • 3次元心エコー図法による二次性三先弁閉鎖不全症に関与する因子の検討
    郡山 恵子, 田中 秀和, 曽我 文隆, 高田 裕基, 堂國 久美子, 羽渓 優, 松添 弘樹, 畑沢 圭子, 下浦 広之, 大岡 順一, 佐野 浩之, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 平田 健一
    日本超音波医学会第89 回学術集会, 2016年05月, 日本語, 日本超音波医学会, 京都, 背景：中等度以上の二次性三尖弁閉鎖不全症（TR）は、右心不全の増悪因子となり、右心系のみならず左心系の疾患の予後増悪因子になることが知られている。中等度以上の二次性TRに関与する因子として弁輪拡大やtetheringによるメカニズムが報告されているが、二次性TRの原因は多岐にわたり、それらの進行の様式の違いは明らかではない。目的：3次元心エコー図法を用いて三尖弁の形態評価を行い、中等度以上の二次性TRに関与する因子と、それらの因子に影響を与えている右心系の要因を検討すること。方法：二次性TRを有する65名を対象とした（心房中隔欠損症：25名、肺高血圧症：21名、拡張型心筋症：19名）。TRは逆流ジェットエリアおよびその右房面積との比にvena contracta、肝静脈逆流波を加味して重症度を評価行った。三尖弁の形態指標として3次元心エコー図を用いて, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 肺高血圧症患者では、何が治療後の右室reverse remodelingに関与しているのか?
    佐野 浩之, 田中 秀和, 元地 由樹, 福田 優子, 高田 裕基, 曽我 文隆, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 大岡 順一, 下浦 広之, 佐和 琢磨, 望月 泰秀, 郡山 恵子, 松本 賢亮, 江本 憲昭, 平田 健一
    第27回日本心エコー図学会学術集会, 2016年04月, 日本語, 日本心エコー図学会, 大阪, 【背景】肺高血圧患者では様々な因子が予後と関連しているが、中でも右室収縮能は重要であり、右室収縮能障害の進行は予後と関連している。我々は治療後中期の右室のreverse remodelingが長期予後と密接に関連していることを最近報告した。しかしながら、肺高血圧患者における治療後の右室reverse remodelingを規定する因子は明らかではない。【方法】肺高血圧患者54例を対象とした（安静時平均肺動脈圧：38±10mmHg）。心エコー図検査は治療前と治療後10.2±9.6ヵ月後に施行した。治療後の右室reverse remodelingは右室収縮末期面積の15%以上の相対的な減少と定義した。長期予後予測の検討は、エンドポイントを死亡または右心不全による入院とし、5年間追跡した。【結果】54人中10人（19%）にイベントが発生した（死亡：7人、右, 国内会議
    口頭発表（一般）

  • 左室長軸方向の収縮能低下と同期不全の増大が糖尿病患者の拡張能低下に及ぼす影響
    望月泰秀, 田中秀和, 曽我文隆, 高田裕基, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 下浦広之, 佐野浩之, 大岡順一, 佐和琢磨, 漁恵子, 松本賢亮, 平田健一
    第27回日本心エコー図学会学術集会, 2016年04月, 日本語, 日本心エコー図学会, 大阪, 【目的】左室拡張能障害が糖尿病性心筋症の初期指標と考えられてきたが、我々は心周期全体での心機能評価の重要性を考え、左室長軸方向の収縮能低下や同期不全が拡張能に及ぼす影響について検証した。【方法】左室駆出率が保持され、冠疾患が否定された糖尿病患者177例と年齢、性別をマッチさせた健常者82例を対象とした。2次元スペックルトラッキング法を用い、心尖部18領域からglobal longitudinal strain (GLS)、time-to-peak strainの標準偏差であるDispersion indexを計測した。先行文献に基づきGLS＜18%を左室収縮能低下群と規定した。【結果】ANCOVA（共変量＝年齢）では健常者、GLSの保持された糖尿病患者、GLSの低下した糖尿病患者の順で拡張能指標は段階的な悪化を示した。糖尿病患者での多変量解析では、E, 国内会議
    口頭発表（一般）

  • 完全房室ブロックで発症し、悪性が疑われた大動脈周囲腫瘍の1例
    高田裕基, 松本賢亮, 田中秀和, 曽我文隆, 羽渓優, 松添弘樹, 畑澤圭子, 堂國久美子, 下浦広之, 佐野浩之, 大岡順一, 佐和琢磨, 望月泰秀, 郡山恵子, 平田健一
    第27回日本心エコー図学会学術集会, 2016年04月, 日本語, 日本心エコー図学会, 大阪, 症例は既往歴のない56歳女性。2015年8月2日自宅で椅子に座っている時に意識消失を来したが経過観察とした。翌日には歩行時の浮遊感を自覚しその後に再度意識消失を来した。その後も意識消失を繰り返し認めたため8月7日に近医を受診され心電図上高度房室ブロックを認めたためペースメーカー植え込み術目的で8月10日に高次病院へ入院となった。入院後の経胸壁心エコー図検査で大動脈周囲の腫瘤を認め、心臓MRIで同部位にT2W1で高信号、遅延造影でのenhanceを認めた。その後に完全房室ブロック、うっ血肝の増悪を認めたため右内頸静脈より一時ペースメーカーを留置された。悪性リンパ腫や肉腫など悪性腫瘍に伴う可能性を考慮され、精査加療目的に8月11日に当院へ転院となった。当院にて施行した経胸壁心エコー図検査では大動脈周囲に最大径27.1×12.7mmの比較的平滑で可動性のな, 国内会議
    口頭発表（一般）

  • プラクティカルセッション4 スペックルトラッキング法を使いこなす 『心不全・ディスシンクロニーで使いこなす』
    松本 賢亮
    第27回日本心エコー図学会学術集会, 2016年04月, 日本語, 日本心エコー図学会, 大阪, 心不全及び心臓同期不全におけるスペックルトラッキングエコー法についての解説。, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • Heart Failure with Functional Mitral Valve Stenosis Due to Left Ventricular Myxoma Originating from Papillary Muscle
    Hidekazu Tanaka, Hiroyuki Shimoura, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yasuhide Mochizuki, Keiko Ryo-Koriyama, Kensuke Matsumoto, Yutaka Okita, Ken-ichi Hirata
    第27回日本心エコー図学会学術集会, 2016年04月, 英語, 日本心エコー図学会, 大阪, A 58-year-old female was admitted to our hospital because of exertional dyspnea. Echocardiography revealed a 20× 35 mm mass arising from the papillary muscles and involved the chordae tendineae. The mass was seen across the mitral valve in diastole, causing functional mitral stenosis with a mean gradient of 9.3 mmHg. A complete surgical excision of a serrated mass with lobulate, 国内会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 2次元スペックルトラッキング法を用いた糖尿病性心筋症の同定とその臨床的患者背景についての検討
    望月泰秀, 田中秀和, 曽我文隆, 高田裕基, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 下浦広之, 佐野浩之, 大岡順一, 佐和琢磨, 漁恵子, 松本賢亮, 平田健一
    第27回日本心エコー図学会学術集会, 2016年04月, 日本語, 日本心エコー図学会, 大阪, 2次元スペックルトラッキング法を用いて初期の糖尿病性心筋症が同定可能であることが報告されているが、どのような特徴をもった糖尿病患者に心筋症が存在するのか知見が少なかった。更に、標準的な拡張能の指標との関連も不明であった。そこで左室駆出率が保持され、冠疾患が否定された糖尿病患者を登録し心エコー図を施行し、心尖部3断面からglobal longitudinal strain (GLS)を計測した。糖尿病の背景、病状、微小血管合併症（腎症、網膜症、神経症）を糖尿病内科専門医が詳細に評価した。合併症として糖尿病性腎症が最も強い糖尿病性心筋症のリスクファクターであり、尿中アルブミン量とGLSには相関関係を認めた。神経症もまた独立した心筋症のリスクファクターであり、神経症の鋭敏な指標であるF波潜時の延長はGLSと強い関連があった。さらに各種左室拡張能の低下にGL, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用について
    Yutaka Hatani, Hidekazu Tanaka, Takuma Sawa, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Hiromasa Otake, Toshiro Shinke, Ken-ichi Hirata
    第80回日本循環器学会学術集会, 2016年03月, 日本語, 日本循環器学会, 仙台, Background: Atrial septal defect (ASD) causes chronic volume overload on right-sided heart, but the potential adverse effects of this long-standing volume overload to left ventricle as well as the response to ASD closure remains unclear. Methods: Fifty-three ASD patients, who underwent transcatheter closure, were studied. Transthoracic echocardiography was performed before and, 国内会議
    口頭発表（一般）

  • Effects of a Change-Over from Other Angiotensin II Receptor Blockers to Olmesartan on Left Ventricular Hypertrophy in Heart Failure Patients
    Hiroyuki Shimoura, Hidekazu Tanaka, Kensuke Matsumoto, Yasuhide Mochizuki, Hiroki Takada, Fumitaka Soga, Yutaka Hatani, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Keiko Ryo, Ken-ichi Hirata
    第80回日本循環器学会学術集会, 2016年03月, 日本語, 日本循環器学会, 仙台, Background: It was reported that olmesartan increases plasma angiotensin-(1-7) through an increase in angiotensin-converting enzyme-related carboxypeptidase expression, resulting in a reducing left ventricular (LV) hypertrophy in animal models. Therefore, our objective was to investigate the effects of a change-over from other angiotensin II receptor blockers (ARBs) to olmesart, 国内会議
    口頭発表（一般）

  • Comprehensive Functional Assessment of Right-Sided Heart Using Speckle-Tracking Strain for Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Keiko Ryo, Yoshiki Motoji, Hiroyuki Sano, Hiroyuki Shimoura, Junichi Ooka, Hiromi Toki, Takuma Sawa, Yasuhide Mochizuki, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
    第80回日本循環器学会学術集会, 2016年03月, 日本語, 日本循環器学会, 仙台, Background: Right ventricular (RV) function is an important determinant of outcome for pulmonary hypertension (PH) patients, and elevated right atrial (RA) pressure is reported to be a prognostic factor. The purpose of this study was to evaluate the relationship between hemodynamic RA parameters and RA function using two-dimensional speckle-tracking strain, and to test the hypo, 国内会議
    口頭発表（一般）

  • 先天性心疾患由来肺高血圧症における術後肺高血圧症の特徴
    中山和彦, 鈴木陽子, 新倉悠人, 玉田直己, 谷仲謙一, 松本賢亮, 田中秀和, 大竹寛雅, 新家俊郎, 平田健一, 江本憲昭
    第18回日本成人先天性心疾患学会学術集会, 2016年01月, 日本語, 日本成人先天性心疾患学会 (JSACHD), 大阪, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 経皮的心房中隔欠損閉鎖術前後における両心室間の相互作用について
    羽渓優, 田中秀和, 佐和琢磨, 高田裕基, 曽我文隆畑澤圭子, 松添弘樹, 下浦広之, 大岡順一, 佐野浩之, 望月泰秀, 漁恵子, 松本賢亮, 大竹寛雅, 新家俊郎, 平田健一
    第18回日本成人先天性心疾患学会 総会, 2016年01月, 日本語, 日本成人先天性心疾患学会, 大阪, 【背景】近年高齢者の心房中隔欠損（ASD）患者における経皮的心房中隔欠損閉鎖術（ASO）は増加傾向にある。その一方でASO前後における両心室間の相互関係や、ASO後の左室心拍出量の増加に寄与する因子については十分に検討されていない。【目的】ASO術後長期における両心室の変化を検討することと、ASO前後で左室の心拍出量増加に寄与する因子が何であるかを検討した。【方法】ASOを施行されたASD患者70名を対象とした。患者の平均年齢は57±16歳で42例（60％）が女性であった。また左室駆出率は72±8%（全て≥55％）を対象とし、術前および術後3ヶ月に心臓超音波検査を施行し、それに加えspeckle-tracking法を用いて、18領域のpeak strain値の平均であるGlobal longitudinal strain (GLS)、各18領域におけ, 国内会議
    ポスター発表

  • 胸郭形成異常を伴う右室二腔症の一例
    漁 恵子, 松本 賢亮, 城戸 佐知子, 辻 隆之, 森 俊平, 平田 健一
    第18回成人先天性心疾患学会, 2016年01月, 日本語, 日本成人先天性心疾患学会, 大阪, 国内会議
    ポスター発表

  • Utility of Isovolumic Contraction Peak Velocity for Evaluation of Adult Patient Status after Transcatheter Closure of Atrial Septal Defect
    佐和 琢磨, 松本 賢亮, 田中 秀和, 平田 健一, Mana Hiraishi, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Hiromasa Otake, Toshiro Shinke, Ken-ichi Hirata
    第18回日本成人先天性心疾患学会 総会, 2016年01月, 日本語, 日本成人先天性心疾患学会, 大阪, Background: Prognostic factors after transcatheter closure for adult patients with atrial septal defect (ASD) have not been fully identified. Methods: Forty-nine patients who underwent transcatheter ASD closure were recruited for this study. Echocardiogra, 国内会議
    口頭発表（一般）

  • 軽度左室機能低下患者における右室ペーシングの影響
    大岡 順一, 田中 秀和, 高田 裕基, 曽我 文隆, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 佐野 浩之, 佐和 琢磨, 元地 由樹, 望月 泰秀, 漁 恵子, 松本 賢亮, 平田 健一
    第120回日本循環器学会近畿地方会, 2015年11月, 日本語, Kinki Regional Office of the Japanese Circulation Society, 大阪, 【背景】徐脈性不整脈の患者においては、恒久的ペースメーカー療法後の左室駆出率（EF）の低下を事前に予測する事は困難である。【目的】右室ペーシングによる心機能低下の違いを検討すること。【方法】植え込み型除細動器が植え込まれた38例を対象とし、安静時、右室ペーシング時のEFの変化ならびに左室内同期不全の程度を比較した。【結果】EF軽度低下群（35-50%、17例）ではEF正常群（50%以上、21例）と比較して、右室ペーシングによるEFの低下が有意に大であり、また左室内同期不全が有意に悪化した。【結論】心臓再同期療法の適応基準を満たさないEFが軽度低下した徐脈性不整脈症例では、通常のペースメーカーの植え込みでなく、心臓再同期療法を選択した方が将来の心筋障害を予防できる可能性が示唆された。, 国内会議
    口頭発表（一般）

  • Risk Stratification of Future Left Ventricular Dysfunction in Patients with Indication for Right Ventricular Pacing Owing to Bradycardia
    Junichi Ooka, Hidekazu Tanaka, Yutaka Hatani, Keiko Hatazawa, Kumiko Dokuni, Hiroki Matsuzoe, Hiroyuki Shimoura, Hiroyuki Sano, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Kensuke Matsumoto, Ken-ichi Hirata
    American Heart Association scientific session 2015, 2015年11月, 英語, American Heart Association, Orland, USA, Background: Although right ventricular (RV) pacing is the only effective treatment for patients with symptomatic atrioventricular block, it creates left ventricular (LV) mechanical dyssynchrony, which can induce LV dysfunction and heart failure. Current criterion for consideration of cardiac resynchronization therapy (CRT) is LV ejection fraction (LVEF) ≤35%, but indication for, 国際会議
    ポスター発表

  • Left ventricular dyssynergy and dispersion as determinant factors of fatal ventricular arrhythmias in patients with mildly reduced ejection fraction
    Hiroki Matsuzoe, Hidekazu Tanaka, Kensuke Matsumoto, Kumiko Dokuni, Yutaka Hatani, Keiko Hatazawa, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Koji Fukuzawa, Ken-ichi Hirata
    American Heart Association scientific session 2015, 2015年11月, 英語, American Heart Association, Orland, USA, Background: Current guidelines recommend implantation of prophylactic implantable cardioverter-defibrillators (ICD) in patients with left ventricular (LV) ejection fraction (EF) <35%. We explored the prognostic factors of fatal ventricular arrhythmias for heart failure (HF) patients with LVEF ≥35%. Methods: We retrospectively studied 72 patients with LVEF of 52±12% (all ≥35%) w, 国際会議
    ポスター発表

  • Increasing Stimulus Strength of Coronary Sinus Pacing Improved Left Ventricular Mechanical Dyssynchrony and Contractile Function in Patients with Reduced Ejection Fraction
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Dokuni Kumiko, Yutaka Hatani, Keiko Hatazawa, Hiroaki Matsuzoe, Junichi Ooka, Hiroyuki Sano, Hiroyuki Shimoura, Takuma Sawa, Yoshiki Motoji, Yasuhide Mochizuki, Keiko Ryo, Koji Fukuzawa
    American Heart Association scientific session 2015, 2015年11月, 英語, American Heart Association, Orland, USA, Introduction: Increasing stimulus strength of left ventricular (LV) coronary sinus pacing decreases QRS duration and inter-ventricular conduction time. Hypothesis: Increasing stimulus strength of LV coronary sinus pacing improves LV mechanical dyssynchrony and myocardial function. Methods: We studied 35 patients with 6±4 months after cardiac resynchronization therapy (LV ejecti, 国際会議
    ポスター発表

  • Association of Three-Dimensional Tricuspid Valve Deformation with Functional Tricuspid Regurgitation
    Keiko Ryo, Hidekazu Tanaka, Kumiko Dokuni, Yutaka Hanani, Hiroki Matsuzoe, Keiko Hatazawa, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Kazuhiro Tatsumi, Kensuke Matsumoto, Ken-ichi Hirata
    American Heart Association scientific session 2015, 2015年11月, 英語, American Heart Association, Orland, USA, Introduction: Background: Functional tricuspid regurgitation (FTR) is widely recognized as being associated with poor outcomes in patients with various cardiac diseases, and the tricuspid valve (TV) deformation is an important mechanism of FTR. However, the precise assessment of TV deformation by means of two-dimensional echocardiography is limited. Purpose: The purpose of this, 国際会議
    ポスター発表

  • 左心不全患者における統合的両心室収縮予備能の有用性
    田中 秀和, 松本 賢亮, 平田 健一
    第19回日本心不全学会学術集会, 2015年10月, 日本語, 日本心不全学会, 大阪, Aim: Right ventricular (RV) as well as left ventricular (LV) function, has been recognized as an important prognostic factor for heart failure patients. Our objective was to investigate the prognostic significance of combined assessment of bi-ventricular functional reserve for patients with dilated cardiomyopathy (DCM)., 国内会議
    シンポジウム・ワークショップパネル（公募）

  • インドネシアと日本における心房中隔欠損症患者の疫学比較調査
    中山 和彦, Lucia KrisDinarti, Anggrahini Dyah Wulan, Anggoro Budi Hartopo, 鈴木 陽子, 松本 賢亮, 田中 秀和, 新家 俊郎, 平田 健一, 江本 憲昭
    第4回日本肺循環学会（JPCS）第3回日本肺高血圧学会（JPHS）合同学術総会, 2015年10月, 日本語, 日本肺循環学会（JPCS）/日本肺高血圧学会（JPHS）, 東京, 国内会議
    口頭発表（一般）

  • "EFFECTS OF RED LIGHT-EMITTING DIODE IRRADIATION ON THE PROLIFERATION AND DIFFERENTIATION OF PREOSTEOBLASTIC MC3T3-E1 CELLS,
    Suzuki H, Asai T, Enomoto Y, Kitayama M, Matsumoto K, Kimoto A, Shigeoka M, Chikazu D, Komori T
    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 日本語, メルボルン, オーストラリア, 国際会議
    口頭発表（一般）

  • 肺高血圧症患者における右室収縮能と左室filling及び予後との相関
    元地由樹, 田中秀和, 福田優子, 堂圀久美子, 羽溪優, 畑澤圭子, 松添弘樹, 土岐啓己, 下浦広之, 大岡順一, 佐野浩之, 佐和琢磨, 望月泰秀, 漁恵子, 松本賢亮, 江本憲昭, 平田健一
    The 64th Annusl Scientific Session of the American College of Cardiology, 2015年03月, 英語, American College of Cardiology, San Diego, USA, 肺高血圧症患者において、右室収縮能と左室のfillingは相関し、これらは予後とも関連する, 国際会議
    口頭発表（一般）

  • 肺高血圧患者における薬剤投与後の右室機能と右室リバースリモデリングについて
    佐野 浩之, 田中 秀和, 元地 由樹, 福田 優子, 堂國 久美子, 羽渓 優, 畑澤 圭子, 松添 弘樹, 土岐 啓己, 下浦 広之, 大岡 順一, 佐和 琢磨, 望月 泰秀, 漁 恵子, 松本 賢亮, 江本 憲昭, 平田 健一
    The 64th Annusl Scientific Session of the American College of Cardiology, 2015年03月, 英語, American College of Cardiology, San Diego, USA, 肺高血圧患者の右心機能と薬剤治療後中期の右室リバースリモデリングを組み合わせた評価は今後肺高血圧治療の管理における指標になる可能性がある。, 国際会議
    ポスター発表

  • 糖尿病患者における潜在性左室心筋障害と微小血管合併症との関連性
    望月泰秀, 田中秀和, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 下浦広之, 佐野浩之, 大岡順一, 土岐啓己, 佐和琢磨, 元地由樹, 漁恵子, 松本賢亮, 平田健一
    第26回 日本心エコー図学会学術集会, 2015年03月, 日本語, 日本心エコー図学会, 北九州, 【背景】糖尿病患者における無症候性左室心筋障害が近年報告され、特に左室長軸方向の心筋収縮能の低下は心不全発症の独立した危険因子であるとされている。一方で心筋障害をきたす患者背景の特徴、危険因子の層別化は十分検討されていない。【方法】冠動脈疾患のない左室駆出率の保たれた糖尿病患者117例を対象とした（年齢：59±14歳、女性：63例、左室駆出率：66±4%）。Global longitudinal strain（GLS）は2次元スペックルトラッキング法を用いて左室心尖部3断面から算出し、過去の報告に基づき糖尿病患者における左室心筋障害をGLS<18%と定義した。24時間蓄尿での尿中アルブミン量30mg/日以上を腎症、末梢神経症状と神経伝達速度異常が存在する例を神経症、単純性網膜症以上の存在を網膜症、Body Mass Index≥25kg/m2を肥満と, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 糖尿病患者における潜在性左室心筋障害と微小血管合併症との関連性
    望月泰秀, 田中秀和, 堂國久美子, 羽渓優, 畑澤圭子, 松添弘樹, 下浦広之, 佐野浩之, 大岡順一, 土岐啓己, 佐和琢磨, 元地由樹, 漁恵子, 松本賢亮, 平田健一
    The 64th Annusl Scientific Session of the American College of Cardiology, 2015年03月, 英語, American College of Cardiology, San Diego, USA, Background: Left ventricular (LV) longitudinal function was related to subclinical LV dysfunction and development of heart failure in patients with diabetes mellitus (DM) and preserved LV ejection fraction (EF). However, the association of LV longitudinal dysfunction with major three diabetes-related microvascular complications including nephropathy, retinopathy and neuropathy, 国際会議
    ポスター発表

  • Glenn手術既往のある心室品拍患者に対して、心外膜にICDリードを留置した1例
    小西弘樹, 福沢公二, 吉田明弘, 中西智之, 山下宗一郎, 松本晃典, 市堀博俊, 兵庫聖大, 今田宙志, 松本賢亮, 田中秀和, 平田健一, 井上武, 大北裕
    第7回植込みデバイス関連冬季大会, 2015年02月, 日本語, 日本不整脈学会, 東京, 国内会議
    口頭発表（一般）

  • 血液培養陰性の疣腫により多発性脳梗塞と高度僧帽弁閉鎖不全症をきたした一例
    堂國 久美子, 松本 賢亮, 田中 秀和, 羽渓 優, 畑澤 圭子, 松添 弘樹, 下浦 広之, 大岡 順一, 佐野 浩之, 土岐 啓己, 佐和 琢磨, 元地 由樹, 望月 泰秀, 漁 恵子, 井上 武, 大北 裕, 平田 健一
    第5回 日本心臓弁膜症学会, 2014年12月, 日本語, Japanese Society of Heart Valve Disease, 東京, 症例は56歳男性。突然の構音障害と両下肢脱力を主訴に当院を受診した。頭部MRI検査にて左頭頂葉と右小脳半球に急性期～慢性期の混在した多発性脳梗塞が指摘された。患者は3年前にも同様の下肢脱力発作を認めていたが、症状は一過性であり医療機関は受診していなかった。繰り返す脳梗塞の精査のために心エコー図検査が施行されたところ、僧帽弁A2およびP2の左房側に可動性を有する疣腫を認め、また疣腫による弁尖接合不全とこれに伴う高度の僧帽弁逆流を認めた。臨床所見および血液検査所見上感染所見は皆無であり、また血液培養を繰り返すもすべて陰性であった。その後、先天性血液凝固異常症精査のために行われた免疫血清検査にて、抗リン脂質抗体およびループスアンチコアグラントがともに陽性であることが判明し、原発性抗リン脂質抗体症候群と診断した。僧帽弁に付着する無菌性疣腫は抗リン脂質抗体症候, 国内会議
    ポスター発表

  • 肺高血圧患者における薬剤投与後の右室機能と右室リバースリモデリングについて
    佐野 浩之, 田中 秀和, 元地 由樹, 福田 優子, 大岡 順一, 下浦 広之, 土岐 啓己, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    American Heart Association Scientific session 2014, 2014年11月, 英語, American Heart Association, Cicago, USA, 肺高血圧の薬物治療後中期の右室revers remodelingは長期予後と関連しており、今後肺高血圧治療の管理における指標になる可能性がある。, 国際会議
    ポスター発表

  • 大動脈解離に合併した感染性動脈内膜炎の1例
    望月泰秀, 田中秀和, 下浦広之, 佐野浩之, 大岡順一, 土岐啓己, 佐和琢磨, 元地由樹, 松本賢亮, 平田健一
    第41回日本超音波医学会学術集会 関西地方会, 2014年11月, 日本語, 日本超音波医学会, 京都, 【症例】74歳男性。発熱と意識障害で近医に入院となり、髄液検査より細菌性髄膜炎と診断された。また、胸腹部造影CTにてStanford B型の偽腔開存型大動脈解離が指摘された。血液ならびに髄液培養からStreptococcus agalactiaeが検出され、感受性のあるABPCとCTRXの投与により、意識障害は改善したものの発熱が続くため、精査加療目的にて当科転院となった。経食道心エコー図検査では、下行大動脈のentry部の血管内膜の著明な肥厚と疣贅が明瞭に観察され、感染性動脈内膜炎と診断した。当院心臓血管外科にて人工血置換術が施行され、術後は平熱に復した。entry部位の組織学的所見では内膜と中膜間の解離部に好中球の浸潤と核塵の集積が認められた。【まとめ】感染性動脈内膜炎は先天性心疾患に合併することが多く、本症例のように大動脈解離に合併することは極, 国内会議
    口頭発表（一般）

  • 大動脈一尖弁に合併した高度大動脈弁閉鎖不全症の一症例
    堂國 久美子, 田中 秀和, 望月 泰秀, 下浦 広之, 大岡 順一, 土岐 啓己, 佐和 琢磨, 元地 由樹, 松本 賢亮, 平田 健一
    第41回日本超音波医学会学術集会 関西地方会, 2014年11月, 日本語, 日本超音波医学会, 京都, 国内会議
    口頭発表（一般）

  • Utility of Combined Assessment of Exercise Oscillatory Breathing and Global Circumferential Strain to Predict Cardiac Events in Heart Failure Patients
    田中 秀和, 坪井 康典, 松本 賢亮, 堂國 久美子, 羽渓 優, 松添 弘樹, 畑澤 圭子, 土岐 啓巳, 下浦 広之, 大岡 順一, 佐野 浩之, 佐和 琢磨, 元地 由樹, 望月 泰秀, 辰巳 和宏, 酒井 良忠, 平田 健一
    American Heart Association Scientific session 2014, 2014年11月, 英語, American Heart Association, Chicago, USA, Background: The occurrence of cardiopulmonary exercise testing-derived exercise oscillatory breathing (EOB) is a predictor of survival in heart failure (HF) patients. Whereas, it was recently reported that global circumferential strain (GCS) as assessed by two-dimensional speckle-tracking imaging reflects intrinsic left ventricular (LV) myocardial function and is a powerful pre, 国際会議
    ポスター発表

  • Right Atrial Function as Prognostic factor in Patients with Pulmonary Hypertension
    福田 優子, 田中 秀和, 元地 由樹, 漁 恵子, 松添 弘樹, 畑澤 圭子, 羽溪 優, 堂國 久美子, 土岐 啓己, 下浦 広之, 大岡 順一, 佐野 浩之, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    American Heart Association Scientific session 2014, 2014年11月, 英語, American Heart Association, Chiｃago, USA, 右房ストレインは血行動態指標と関連しており、肺高血圧症患者の管理において有用である可能性がある。, 国際会議
    ポスター発表

  • Integrated Assessment of Bi-ventricular Contractile Reserve under Dobutamine Stress Offers an Incremental Prognostic Value for Patients with Dilated Cardiomyopathy
    松本賢亮, 田中秀和, 堂國久美子, 羽渓優, 松添弘樹, 畑澤圭子, 土岐啓巳, 下浦広之, 大岡順一, 佐野浩之, 佐和琢磨, 元地由樹, 望月泰秀, 辰巳和宏, 平田健一
    American Heart Association Scientific session 2014, 2014年11月, 英語, American Heart Association, Chicago, USA, Assessment of right ventricular contractile reserve during dobutamine stress offers a significantly better prognostic value for patients with dilated cardiomyopathy. Further, combined assessment of bi-ventricular functional reserve may make a major contribution to better management of these patients., 国際会議
    口頭発表（一般）

  • Efficacy of Combining Assessment of Right Ventricular Function and Right Atrial Remodeling as Prognostic Factor in Patients with Pulmonary Hypertension
    福田 優子, 田中 秀和, 元地 由樹, 漁 恵子, 松添 弘樹, 畑澤 圭子, 羽溪 優, 堂國 久美子, 土岐 啓己, 下浦 広之, 大岡 順一, 佐野 浩之, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    American Heart Association Scientific session 2014, 2014年11月, 英語, American Heart Association, Chiｃago, USA, 右室機能と右房リモデリングを組み合わせると、より正確に肺高血圧患者の予後を予測することができる可能性がある。, 国際会議
    ポスター発表

  • 先天性心疾患の欠損孔サイズが肺高血圧発症に及ぼす影響評価
    中山和彦, 江本憲昭, 絹谷洋人, 新倉悠人, 鈴木陽子, 元地由樹, 新家俊郎, 松本賢亮, 田中秀和, 平田健一
    第2回日本肺高血圧学会/第3回日本肺循環学会 合同学術集会, 2014年10月, 日本語, 日本肺高血圧学会/日本肺循環学会, 東京, 国内会議
    口頭発表（一般）

  • 異なる発症機序による体循環-肺循環短絡を伴う肺高血圧症の2例
    中山和彦, 江本憲昭, 絹谷洋人, 新倉悠人, 鈴木陽子, 元地由樹, 新家俊郎, 松本賢亮, 田中秀和, 平田健一
    第2回日本肺高血圧学会/第3回日本肺循環学会 合同学術集会, 2014年10月, 日本語, 日本肺高血圧学会/日本肺循環学会, 東京, 国内会議
    口頭発表（一般）

  • Is Cardiac Resynchronization Theraphy Contraindicated in Heart Failure Patients with A Narrow QRS Complex?
    田中秀和, 松本賢亮, 辰巳和宏, 佐和琢磨, 元地由樹, 望月泰秀, 吉田明弘, 平田健一
    第18回日本心不全学会学術集会, 2014年10月, 日本語, 日本心不全学会, 大阪, 国内会議
    口頭発表（一般）

  • 肺高血圧患者の右室reverse remodelingと長期予後の関連について
    佐野 浩之, 田中 秀和, 元地 由樹, 福田 優子, 大岡 順一, 下浦 広之, 土岐 啓己, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    第62回日本心臓病学会学術集会, 2014年09月, 日本語, 日本心臓病学会, 仙台, 肺高血圧の薬物治療後中期の右室revers remodelingは長期予後と関連しており、今後肺高血圧治療の管理における指標になる可能性がある。, 国内会議
    口頭発表（一般）

  • 心尖部Lotationと右室パフォーマンスの影響 について
    元地 由樹, 田中 秀和, 福田 優子, 佐野 浩之, 漁 恵子, 下浦 広之, 大岡 順一, 土岐 啓巳, 佐和 琢磨, 山鳥 嘉樹, 三好 達也, 今西 純一, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲明, 平田 健一
    ヨーロッパ心臓病学会2014, 2014年08月, 英語, ヨーロッパ心臓病学会, Barcelona, Spain, TAPSE may be overestimated in PH patients with clockwise rotation resulting from LV compression. TAPSE should thus be evaluated carefully in PH patients with marked apical rotation., 国際会議
    ポスター発表

  • Glenn手術既往のある心室品拍患者に対して、心外膜にICDリードを留置した1例
    小西弘樹, 福沢公二, 吉田明弘, 松本賢亮, 藤原竜童, 鈴木敦, 中西智之, 山下宗一郎, 松本晃典, 市堀博俊, 山下智也, 高谷具史, 平田健一, 井上武, 大北裕
    第117回日本循環器学会近畿地方会, 2014年07月, 日本語, 日本循環器学会近畿支部, 大阪, 国内会議
    口頭発表（一般）

  • Association of Right Ventricular Reverse Remodeling with Long-Term Outcomes in Patients with Pulmonary Hypertension
    佐野 浩之, 田中 秀和, 元地 由樹, 福田 優子, 大岡 順一, 下浦 広之, 土岐 啓己, 佐和 琢磨, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    American Society of Echocardiography, 25th Annual Scientific Sessions, 2014年06月, 英語, American Society of Echocardiography, Portland, USA, Mid-term RV reverse remodeling after adding PH-specific drugs was associated with long-term outcomes, and may well have clinical implications for better management of PH patients., 国際会議
    ポスター発表

  • Association of Left Atrial Booster-Pump Function with Heart Failure Symptom in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction
    今西 純一, 田中 秀和, 大岡 順一, 佐野 浩之, 土岐 啓己, 下浦 広之, 佐和 琢磨, 山鳥 嘉樹, 元地 由樹, 三好 達也, 望月 泰秀, 福田 優子, 辰巳 和宏, 松本 賢亮, 大北 裕, 平田 健一
    American Society of Echocardiography, 25th Annual Scientific Sessions, 2014年06月, 英語, American Society of Echocardiography, Portland, USA, 国際会議
    ポスター発表

  • 三尖弁閉鎖不全症を合併した卵円孔開存に伴う低酸素血症の一例
    下浦 広之, 田中 秀和, 松本 賢亮, 土岐 啓己, 今西 純一, 三好 達也, 元地 由樹, 望月 泰秀, 佐和 琢磨, 平田 健一
    第87回日本超音波医学会学術集会, 2014年05月, 日本語, 日本超音波医学会, 横浜, 【はじめに】卵円孔は胎生期に形成される心房中隔の開口部で、出生後、呼吸の開始により自然に閉鎖するが、中には成人に達しても自然閉鎖が見られない場合がある。剖検例や経食道心エコー図による検討では成人の約１０〜２５％認められ、多くの症例は無症状であるが、奇異性塞栓症あるいはplatypnea-orthodeoxia syndromeを来す症例は外科的、経皮的な閉鎖術の適応となる。【症例】約１０年前にベトナムから来日した43歳男性で、粟粒結核、心室中隔欠損症の既往がある。2009年頃より労作時の呼吸困難が出現し、仕事の継続が困難となっていた。前医を受診し、低酸素血症を指摘されて精査を行うも、原因を明らかに出来ず経過観察となっていたが、その後も徐々に症状が増悪して日常生活に支障をきたすようになった（NYHA III）ため、精査目的に当院へ紹介となった。安静時室, 国内会議
    口頭発表（一般）

  • 好酸球増加症における左室心内膜障害の検討
    山本哲志, 田中秀和, 松本賢亮, 三好達也, 今西純一, 栗本千代, 今西孝充, 林伸英, 平田健一, 河野誠司
    日本超音波医学会第87回学術集会, 2014年05月, 日本語, 日本超音波医学会, 横浜, 国内会議
    口頭発表（一般）

  • シャント量の少ない心房中隔欠損症に対する経カテーテル的閉鎖術の意義
    佐和琢磨, 田中秀和, 平石真奈, 元地由樹, 今西純一, 三好達也, 望月泰秀, 松本賢亮, 新家俊郎, 平田健一
    第87回日本超音波医学会学術集会, 2014年05月, 日本語, 日本超音波医学会, 横浜, ASD患者に対するカテーテル閉鎖術ではシャント量の少ない患者群でも、シャント量の多い患者群と同等の血行動態の改善が得られた, 国内会議
    口頭発表（一般）

  • 非虚血性心筋症患者に対するドブタミン負荷心エコー図検査の実際〜どのように行い、何を評価すべきか〜
    松本賢亮, 田中秀和, 平田健一
    第25回に本心エコー図学会, 2014年04月, 日本語, 日本心エコー図学会, 金沢, 非虚血性心筋症に対する負荷心エコー図検査の役割は未だ定まっていない．そのため、その意義、具体的方法などにつき概説する．, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 肺高血圧症患者のTAPSE評価におけるlongitudinal apical rotationの影響
    元地由樹, 田中秀和, 福田優子, 佐野浩之, 下浦広之, 土岐啓己, 大岡順一, 佐和琢磨, 山鳥嘉樹, 今西純一, 三好達也, 望月泰秀, 辰巳和宏, 松本賢亮, 江本憲昭, 平田健一
    第25回日本心エコー図学会学術集会, 2014年04月, 日本語, 日本心エコー図学会, 金沢, PH患者においては、TAPSEはRV-freeと異なり、収縮期に心尖部が時計回転する患者で過大評価されることが示唆され注意が必要である。, 国内会議
    口頭発表（一般）

  • Duchenne型筋ジストロフィー患者の潜在性左室心筋障害の検出における下肢挙上負荷心エコー図検査の有用性
    山本哲志, 田中秀和, 竹島泰弘, 土岐啓巳, 下浦広之, 大岡順一, 佐野浩之, 佐和琢磨, 山鳥嘉樹, 元地由樹, 三好達也, 今西純一, 望月泰秀, 福田優子, 辰巳和宏, 今西孝充, 松本賢亮, 林伸英, 平田健一, 河野誠司
    第25回日本心エコー図学会学術集会, 2014年04月, 日本語, 日本心エコー図学会, 金沢, 国内会議
    口頭発表（一般）

  • Left Atrial Booster-Pump Function as a Predictive Parameter for New-Onset Postoperative Atrial Fibrillation in Patients with Aortic Stenosis
    今西 純一, 田中 秀和, 大岡 順一, 佐野 浩之, 土岐 啓己, 下浦 広之, 佐和 琢磨, 山鳥嘉樹, 元地由樹, 三好達也, 望月泰秀, 福田優子, 辰巳 和宏, 松本賢亮, 大北 裕, 川合 宏哉, 平田健一
    第78回日本循環器学会学術集会, 2014年03月, 日本語, 日本循環器学会, 東京, Background: Postoperative atrial fibrillation (POAF) is associated with increased risk of embolic events and heart failure, but its associated factors remains unknown. The purpose of our study was to test the hypothesis that preoperative left atrial (LA) subclinical myocardial dysfunction is a potential predictor of development of POAF in patients with aortic stenosis (AS).Meth, 国内会議
    ポスター発表

  • Impact of Right Atrial Volume Index as Prognostic Factor in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto
    第78回日本循環器学会学術集会, 2014年03月, 英語, 日本循環器学会, 東京, Background: Right arterial (RA) pressure has been reported to be a predictor for outcome in pulmonary hypertension (PH) patients, but non-invasive assessment of RA pressure is limited. Our objective was to test the hypothesis that RA volume assessed by two-dimensional echocardiography was correlated with RA pressure by right heart catheterization, and could be a prognostic para, 国内会議
    ポスター発表

  • High Voltage Coronary Sinus Pacing Improved Left Ventricular Endocardial Function in Heart Failure Patients
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Yasuhide Mochizuki, Tatsuya Miyoshi, Yuko Fukuda, Ryudo Fujiwara, Akihiro Yoshida, Ken-ichi Hirata
    第78回日本循環器学会学術集会, 2014年03月, 日本語, 日本循環器学会, 東京, Background: Epicardial left ventricular (LV) pacing is hemodynamically less effective than endocardial LV pacing, whereas high voltage LV coronary sinus pacing decreases QRS duration and inter-ventricular conduction time. Although voltage of coronary sinus pacing has potential to effect the electrical conduction, it is unknown that the associations of voltage of coronary sinus, 国内会議
    ポスター発表

  • Evaluation of Right Atrial Function as Potential Prognostic factor in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto
    第78回日本循環器学会学術集会, 2014年03月, 英語, 日本循環器学会, 東京, Background: The development of right ventricular (RV) dysfunction in patients with pulmonary hypertension (PH) has been associated with adverse outcomes. Right atrial (RA) function could be a prognostic factors as well as RV function, but non-invasive evaluation of RA function is limited. Our objective was thus to test the hypothesis that RA function was associated with hemodyn, 国内会議
    ポスター発表

  • Evaluation of Global Circumferential Strain as Prognostic Marker after Administration of β-blockers in Patients with Dilated Cardiomyopathy
    Hidekazu Tanaka, Kensuke Matsumoto, Junichi Ooka, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Ken-ichi Hirata
    第78回日本循環器学会学術集会, 2014年03月, 英語, 日本循環器学会, 東京, Background: The use of β-blockers has improved the prognosis of dilated cardiomyopathy (DCM). While there are many prognostic predictors, not all of them are applicable to individual patients. Global circumferential strain (GCS) was recently identified as a powerful prognostic marker, which appears to be a better parameter than LV global function for patients with depressed lef, 国内会議
    口頭発表（一般）

  • Endocardial Area Change Rate by Three-dimensional Speckle-tracking as an Accurate Predictor of Left Ventricular Relaxation
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Toshiro Shinke, Ken-ichi Hirata
    第78回日本循環器学会学術集会, 2014年03月, 日本語, 日本循環器学会, 東京, Background: The early diastolic mitral inflow and annulus velocities ratio (E/e') were considered as the parameter to estimate left ventricular (LV) filling pressure. According to the guidelines, this parameter is recommended to use for patients with preserved ejection fraction (EF) (≥50%), but not for patients with depressed EF (<50%). A newly developed three-dimen, 国内会議
    ポスター発表

  • Efficacy of Segmental Circumferential Strain Analysis as a Parameter of Intrinsic Left Ventricular Myocardial Function for Cardiac Resynchronization Therapy
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Hiromi Toki, Hiroyuki Shimoura, Junichi Ooka, Hiroyuki Sano, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Yuko Fukuda, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    American College of Cardiology 63th Annual Scientific Session & Expo, 2014年03月, 英語, American College of Cardiology, Washington DC, USA, Background: Left ventricular (LV) dyssynchrony and intrinsic myocardial function are associated with response to cardiac resynchronization therapy (CRT). However, the presence of significant LV dyssynchrony can underestimate echocardiographic assessment of intrinsic LV myocardial function owing to time-phase mismatch contraction.Methods: We studied 131 CRT patients. LV dyssynch, 国際会議
    ポスター発表

  • Combined Assessment of Bi-ventricular Functional Reserve during Dobutamine Stress Offers a Significant Prognostic Impact for Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Junichi Ooka, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Ken-ichi Hirata
    第78回日本循環器学会学術集会, 2014年03月, 英語, 日本循環器学会, 東京, RV functional reserve as well as LV had significant prognostic impact in patients with DCM. Moreover, combined assessment of bi-ventricular functional reserve may play a key role for better management of such patients., 国内会議
    口頭発表（一般）

  • Association of Left Atrial Booster-Pump Function with Heart Failure Symptoms in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction
    今西 純一, 田中 秀和, 大岡 順一, 佐野 浩之, 土岐 啓己, 下浦 広之, 佐和 琢磨, 山鳥嘉樹, 元地由樹, 三好達也, 望月泰秀, 福田優子, 辰巳 和宏, 松本賢亮, 大北 裕, 川合 宏哉, 平田健一
    第78回日本循環器学会学術集会, 2014年03月, 日本語, 日本循環器学会, 東京, Background: According to the current guidelines for patients with severe aortic stenosis (AS), the management of asymptomatic patients with severe AS and preserved ejection fraction (EF) remains controversial. The aim of this study was thus to assess the association of the development of heart failure symptoms with left atrial (LA) function in patients with severe AS to make us, 国内会議
    ポスター発表

  • Association of Apical Longitudinal Rotation with Tricuspid Annular Plane Systolic Excursion in Patients With Pulmonary Hypertension
    元地由樹, 田中秀和, 福田優子, 漁恵子, 下浦広之, 土岐啓己, 大岡順一, 佐野浩之, 佐和琢磨, 山鳥嘉樹, 今西純一, 三好達也, 望月泰秀, 辰巳和宏, 松本賢亮, 江本憲昭, 平田健一
    American College of Cardiology 2013 Scientific Sessions, 2014年03月, 英語, American College of Cardiology, Washington DC, USA, PH patients had significant apical counterclockwise rotation, resulting in an inaccurate assessment of TAPSE. RV free-wall longitudinal strain may have a potential clinical implication of more accurate parameter for predicting RV function in such patients., 国際会議
    ポスター発表

  • Time course of left ventricular myocardial dysfunction by cardiotoxicity of anthracycline
    T. Miyoshi, H. Tanaka, A. Kaneko, K. Matsumoto, J. Imanishi, Y. Motoji, Y. Mochizuki, H. Minami, H. Kawai, K. Hirata
    EuroEcho-Imaging 2013, 2013年12月, 英語, European Association of Cardiovascular Imaging, Istanbul, Turkey, EF significantly decreased from baseline to 6 months and 12 months after anthracycline administration, but E/E' did not., 国際会議
    ポスター発表

  • Evaluation of endocardial dysfunction in patients with preserved ejection fraction after anthracycline therapy assessed by three-dimensional speckle tracking strain
    T. Miyoshi, H. Tanaka, A. Kaneko, K. Matsumoto, J. Imanishi, Y. Motoji, Y. Mochizuki, H. Minami, H. Kawai, K. Hirata
    EuroEcho-Imaging 2013, 2013年12月, 英語, European Association of Cardiovascular Imaging, Istanbul, Turkey, Only 3D-GAS and peak 3D global circumferential strains of the anthracycline group were significantly worse than those of the control group even though global LV systolic and diastolic functions were similar. 3D-GAS correlated significantly with the cumulative doxorubicin dose. It was noteworthy that multivariate analysis showed only 3D-GAS was independently associated with cumu, 国際会議
    ポスター発表

  • 3D strain for evaluating left ventricular dyssynchrony
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Ken-ichi Hirata
    EuroEcho Imaging 2013, 2013年12月, 英語, European Association of Cardiovascular Imaging, Istanbul, Turkey, Although, there are some limitations regarding 3D speckle tracking echocardiography, 3D echocardiography has a potential to provide more comprehensive evaluation of LV mechanical Dyssynchrony than was previously possible. So I do believe we should use these two methods complementarily for the assessment of dyssynchrony., 国際会議
    [招待有り]
    シンポジウム・ワークショップパネル（指名）

  • 古典的Ehlers-Danlos症候群に合併した高度僧帽弁閉鎖不全症の1例
    望月 泰秀, 田中 秀和, 松本 賢亮, 元地 由樹, 今西 純一, 平石 真奈, 三好 達也, 金子 明弘, 川合 宏哉, 平田 健一
    日本超音波医学会 第40回関西地方会学術集会, 2013年11月, 日本語, 日本超音波医学会, 大阪, 古典的Ehlers-Danlos症候群に合併した稀な高度僧帽弁閉鎖不全症の1例を報告した, 国内会議
    口頭発表（一般）

  • 右房原発血管肉腫の1例
    福島 美野子, 田中 秀和, 松本 賢亮, 金子 明弘, 山本 哲志, 今西 孝充, 林 伸英, 河野 誠司, 川合 宏哉, 平田 健一
    日本超音波医学会 第40回関西地方会学術集会, 2013年11月, 日本語, 日本超音波医学会, 大阪, 右房に発生したまれな血管肉腫の1例を報告した, 国内会議
    口頭発表（一般）

  • Utility of Segmental Circumferential Strain Analysis as a Parameter of Intrinsic Left Ventricular Myocardial Function for Cardiac Resynchronization Therapy
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: Left ventricular (LV) dyssynchrony appears to play a major pathophysiologic role in response to cardiac resynchronization therapy (CRT), and intrinsic LV myocardial function is also associated with response. However, the presence of significant LV dyssynchrony can underestimate the assessment of echocardiographic intrinsic LV myocardial function owing to time-phase, 国際会議
    ポスター発表

  • Parachute-Like Asymmetric Mitral Valveが観察された成人の1症例
    望月泰秀, 田中秀和, 福田優子, 佐野浩之, 大岡順一, 土岐啓己, 下浦広之, 佐和琢磨, 山鳥嘉樹, 元地由樹, 今西純一, 三好達也, 辰巳和宏, 松本賢亮, 平田健一
    日本超音波医学会 第41回関西地方会学術集会, 2013年11月, 日本語, 日本超音波医学会, 大阪, 症例は31歳男性。健診で肺野異常陰影を指摘され前医にて精査中であった。完全右脚ブロックがあり経胸壁心エコー図にて僧帽弁形態異常を指摘され、無症状ではあったが精査目的にて当科紹介となった。経胸壁心エコー図、および経食道心エコー図における観察では僧帽弁両尖からのびる腱索はすべてが前乳頭筋に収束し、僧帽弁口も側壁側に偏位し、パラシュート僧帽弁を想起させた。しかし扁平で短い低形成の後乳頭筋が存在し、左室自由壁の高位より発生し僧帽弁輪に直接繋がっているように観察された。その他先天性心奇形の合併はなく、CTにおいても上行大動脈拡大、大動脈縮窄症などの合併は認めず、先天性心奇形を合併しないParachute-Like Asymmetric Mitral Valve(PLAMV)の成人例と診断した。PLAMVもパラシュート僧帽弁と同様に先天性の乳頭筋形成不全の1つと, 国内会議
    口頭発表（一般）

  • Left Atrial Booster-Pump Function as a Predictive Parameter for New-Onset Postoperative Atrial Fibrillation in Patients with Severe Aortic Stenosis
    Junichi Imanisni, Hidekazu Tanaka, Junichi Ooka, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Takuma Sawa, Yoshiki Yamadori, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: Postoperative atrial fibrillation (AF) has been reported to be associated with long-term mortality following aortic valve replacement (AVR), but its associated factors remains unknown. It was recently reported that left atrial (LA) strain rate parameters was associated with the development of AF in prior studies. We therefore used two-dimensional speckle-tracking st, 国際会議
    ポスター発表

  • Left Atrial "Reservoir" and "Passive Emptying" Reserve during Dobutamine Stress Have Prognostic Relevance for Patients with Dilated Cardiomyopathy
    Kensuke matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Yasuhide Mochizuki, Tatsuya Miyoshi, Yoshiki Motoji, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Diminished augmentation of LA reservoir and passive emptying function is closely associated with adverse cardiovascular event., 国際会議
    口頭発表（一般）

  • Interdependence in the Biventricle and Its Association with Long-Term Outcome in Patients with Pulmonary Hypertension
    元地由樹, 田中秀和, 福田優子, 佐和琢磨, 山鳥嘉樹, 今西純一, 三好達也, 望月泰秀, 辰巳和宏, 松本賢亮, 江本憲昭, 平田健一
    American Heart Association 2013 Scientific Sessions, 2013年11月, 英語, American Heart Association, Dallas, USA, LV circumferential myocardial relaxation expressed in Circ-ESR has a potential to show the biventricular condition, and might be a key parameter for better management of PH patients., 国際会議
    ポスター発表

  • Evaluation of Time Course of Left Ventricular Dysfunction by Cardiotoxicity of Anthracycline
    Tatsuya Miyoshi, Hidekazu Tanaka, Akihiro Kaneko, Kensuke Matsumoto, Kazuhiro Tatsumi, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Yuko Fukuda, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Patients who received anthracycline have LV endocardial dysfunction even if global LV function was preserved. Early detection of minor LV myocardial dysfunction may thus play a clinical role in predicting future global LV systolic dysfunction, 国際会議
    ポスター発表

  • Evaluation of Global Circumferential Strain as Prognostic Marker after Administration of β-blockers in Dilated Cardiomyopathy
    Hidekazu Tanaka, Kensuke Matsumoto, Junichi Ooka, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Ken-ichi Hirata
    Background: The use of β-blockers has improved the prognosis of dilated cardiomyopathy (DCM). While there are many prognostic predictors, not all of them are applicable to individual patients. Global circumferential strain (GCS) was recently identified as, 2013年11月, 英語, 日本循環器学会, 大阪, Background: The use of β-blockers has improved the prognosis of dilated cardiomyopathy (DCM). While there are many prognostic predictors, not all of them are applicable to individual patients. Global circumferential strain (GCS) was recently identified as a powerful prognostic marker, which appears to be a better parameter than LV global function for patients with depressed lef, 国内会議
    口頭発表（一般）

  • Evaluation of Global Circumferential Strain as Prognostic Marker after Administration of β-blockers for Dilated Cardiomyopathy
    Hidekazu Tanaka, Yasuhide Mochizuki, Kensuke Matsumoto, Yoshiki Yamadori, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: The prognosis of dilated cardiomyopathy (DCM) has improved by the use of β-blockers, and the appearance of left ventricular (LV) reverse remodeling is generally thought to result in a favorable prognosis. Although there are many prognostic predictors, they are not sensitive in individual patients. It is recently reported that global circumferential strain (GCS) is a, 国際会議
    口頭発表（一般）

  • Endocardial Area Change Rate by Three-dimensional Speckle-tracking as an Accurate Predictor of Left Ventricular Relaxation
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Toshiro Shinke, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: The early diastolic mitral inflow and annulus velocities ratio (E/e') were considered as the parameter to estimate left ventricular (LV) filling pressure. According to the guidelines, this parameter is recommended to use for patients with preserved ejection fraction (EF) (≥50%), but not for patients with depressed EF (<50%). A newly developed three-dimen, 国際会議
    ポスター発表

  • Easy-to-Use Comprehensive Speckle Tracking Evaluation to Minimize Non-Responders Following Cardiac Resynchronization Therapy
    Yasuhide Mochizuki, Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Takuma Sawa, Yoshiki Yamadori, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Akihiro Yoshida, Mitsuhiro Yokoyama, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: Left ventricular (LV) dyssynchrony has emerged as an important mechanism contributing to response to cardiac resynchronization therapy (CRT), but other potential factors, especially LV myocardial viability, can also influence response to CRT. Therefore, an approach combining assessment of LV dyssynchrony and myocardial viability may well be required.Methods: We stud, 国際会議
    ポスター発表

  • Association of Left Atrial Booster-Pump Function with Heart Failure Symptoms in Patients with Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction
    Junichi Imanisni, Hidekazu Tanaka, Junichi Ooka, Hiroyuki Sano, Hiromi Toki, Hiroyuki Shimoura, Takuma Sawa, Yoshiki Yamadori, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, Background: According to the current guidelines for patients with severe aortic stenosis (AS), the management of asymptomatic patients with severe AS and preserved ejection fraction (EF) remains controversial. The aim of this study was thus to assess the association of the development of heart failure symptoms with left atrial (LA) function in patients with severe AS to make us, 国際会議
    ポスター発表

  • Association of Inter- and Intra-Ventricular Dyssynchrony with Right Ventricular Performance in Patients with Pulmonary Hypertension
    元地由樹, 田中秀和, 福田優子, 佐和琢磨, 山鳥嘉樹, 今西純一, 三好達也, 望月泰秀, 辰巳和宏, 松本賢亮, 江本憲昭, 平田健一
    American Heart Association 2013 Scientific Sessions, 2013年11月, 英語, American Heart Association, Dallas, USA, Intra RV and inter-ventricular dyssynchrony was associated with RV performance and RV after load, and improved after treatment in PH patients. These indices could have the potential to allow for noninvasive follow-up of such patients., 国際会議
    ポスター発表

  • Assessment of Right Ventricular Functional Reserve during Dobutamine Stress Offers a Significant Prognostic Impact for Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yuko Fukuda, Ken-ichi Hirata
    American Heart Association Scientific Session 2013, 2013年11月, 英語, American Heart Association, Dallas, USA, 拡張型心筋症患者に対してドブタミン負荷心エコー図検査を施行し、右室および左室の収縮予備能を観察した。経過観察中に20％の患者が心血管事故を起こしたが、右室収縮予備能、左室収縮予備能ともに独立した心事故の規定因子だった。なお、右室および左室予備能を組み合わせることにより、より正確に心事故を予想することができた。, 国際会議
    ポスター発表

  • 肺高血圧症における左室局所心筋拡張能指標の有用性
    元地 由樹, 田中 秀和, 福田 優子, 佐和 琢磨, 山鳥 嘉樹, 今西 純一, 三好 達也, 望月 泰秀, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 平田 健一
    第61回心臓病学会, 2013年09月, 日本語, 日本心臓病学会, 熊本, 国内会議
    口頭発表（一般）

  • Potential Diagnostic Tool of Two-dimensional Speckle-Tracking Strain to Identify Subclinical Myocardial Dysfunction in Patients with Systemic Sarcoidosis with Preserved Ejection Fraction
    Yumiko Kano, Hidekazu Tanaka, Takayuki Tsuji, Takuma Sawa, Jun-ichi Imanishi, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Kensuke Matsumoto, Tetsushi Yamamoto
    American Society Of Echocardiography 24th Annual scientific Sessions, 2013年06月, 英語, American Society Of Echocardiography, Minneapolis, U.S.A, Background: Sarcoidosis is a systemic granulomatous disease of undefined cause involving multiple organs. Since cardiac involvement in patients with systemic sarcoidosis leads to substantial morbidity and sudden death, early diagnosis and appropriate management for such patients could be important. Accordingly, the objective of this study was to evaluate left ventricular (LV) s, 国際会議
    ポスター発表

  • Duchenne型筋ジストロフィーにおける機能的僧帽弁閉鎖不全症と僧帽弁形態について
    山本 哲志, 田中 秀和, 松本 賢亮, 金子 明弘, 今西 孝充, 林 伸英, 竹島 泰弘, 川合 宏哉, 平田 健一, 河野 誠司
    日本超音波医学会第86回学術集会, 2013年05月, 日本語, 日本超音波医学会, 大阪, 国内会議
    口頭発表（一般）

  • Utility of Right Ventricular Free Wall Longitudinal Speckle-Tracking Strain for Detecting Right Ventricular Performance after Percutaneous Transluminal Pulmonary Angioplasty
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Takuma Sawa, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Tetsuari Onishi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, RV-free has the potential to allow for noninvasive follow-up of patients with distal-type CTEPH referred for PTPA., 国内会議
    口頭発表（一般）

  • Prognostic Value of Right Atrial Volume Index and Its Association of Right Atrial Pressure in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Takuma Sawa, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Tetsuari Onishi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 日本語, 日本循環器学会, 横浜, Non-invasively assessed RA volume index index was associated with RA pressure and long-term outcome in PH patients., 国内会議
    ポスター発表

  • Left Atrial Functional Reserve in "Reservoir" and "Passive Emptying" during Dobutamine Stress Has an Impact on Cardiac Events in Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, ドブタミン負荷心エコー図検査にて評価した左房の予備能は拡張型心筋症患者の予後予測に有用である。, 国内会議
    口頭発表（一般）

  • Impact of Right Ventricular Geometry on Mitral Regurgitation after Transcatheter Closure of Atrial Septal Defect
    Mana Hiraishi, Hidekazu Tanaka, Takuma Sawa, Junichi Imanishi, Yoshiki Motoji, Tatsuya Miyoshi, Yasuhide Mochizuki, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 日本語, 日本循環器学会, 横浜, Impact of Right Ventricular Geometry on Mitral Regurgitation after Transcatheter Closure of Atrial Septal Defect, 国内会議
    口頭発表（一般）

  • Impact of Dynamic Dyssynchrony Assessed by Three-Dimensional Speckle-Tracking Area Strain during Dobutamine Stress on Cardiovascular Events in Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, ドブタミン投与下で評価した左室同期不全は動的に変化する。この左室同期不全の増悪は、拡張型心筋症の患者の予後と関係する。この事実は拡張型心筋症患者の予後評価に寄与する可能性がある。, 国内会議
    口頭発表（一般）

  • Endocardial Dysfunction in Patients with Preserved Ejection Fraction After Anthracycline Therapy Using Three-Dimensional Speckle-Tracking Area Strain
    Tatsuya Miyoshi, Hidekazu Tanaka, Kensuke Matsumoto, Kazuiro Tatsumi, Takuma Sawa, Junichi Imanishi, Yoshiki Motoji, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Tetsuari Onishi, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, 3-D speckle-tracking area strain was found to be useful for evaluating subtle endocardial dysfunction associated with anthracyclines, 国内会議
    ポスター発表

  • Endocardial Dysfunction in Patients with Preserved Ejection Fraction after Anthracycline Therapy as Assessed by Three-Dimensional Speckle-TrackingArea Strain
    Tatsuya Miyoshi, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Yoshiki Yamadori, Takuma Sawa, Junichi Imanishi, YoshikiMotoji, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Hironobu Minami, Hiroya Kawai, Ken-ichi Hirata
    American College of Cardiology Annual Scientific Session 2013, 2013年03月, 英語, American College of Cardiology, San Francisco, CA, 3-D speckle-tracking area strain was found to be useful for evaluating subtle endocardial dysfunction associated with anthracyclines, 国際会議
    ポスター発表

  • Endocardial Area Change Rate by Three-dimensional Speckle-tracking Predicts Left Ventricular Filling Pressures in Heart Failure Patients with Depressed Ejection Fraction
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Yasuhide Mochizuki, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Toshiro Shinke, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 日本語, 日本循環器学会, 横浜, 三次元スペックルトラッキング法を用いた左室拡張指標が左室充満圧を予測できることを報告した, 国内会議
    ポスター発表

  • Easy-to-Use Comprehensive Speckle Tracking Approach to Minimize Non-Responders to Cardiac Resynchronization Therapy
    望月 泰秀, 田中 秀和, 松 本賢亮, 辰巳 和宏, 今西 純一, 佐和 琢磨, 山鳥 嘉樹, 元地 由樹, 三好 達也, 平石 真奈, 金子 明弘, 福田 優子, 大西 哲存, 吉田 明弘, 横山 光宏, 川合 宏哉, 平田 健一
    American College of Cardiology Annual Scientific Session 2013, 2013年03月, 英語, American College of Cardiology, San Francisco, CA, 心臓再同期療法における簡便な左室同期不全と心筋機能評価の評価～2次元Speckle-Tracking Strain法を用いた検討～, 国際会議
    ポスター発表

  • Early Diastolic Area Change Rate by Three-dimensional Speckle Tracking Predicts Left Ventricular Reverse-Remodeling and Long-Term Outcome following Cardiac Resynchronization Therapy
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Tetsuari Onishi, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, 心臓再同期療法による左室拡張能の急性改善が治療後の予後を予測することを三次元スペックルトラッキング法を用いて報告した, 国内会議
    口頭発表（一般）

  • Contractile Reserve Assessed by Three-Dimensional Global Circumferential Speckle-Tracking Strain as a Predictor of Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Tetsuari Onishi, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, 3次元ドブタミン負荷心エコー図検査で評価した、円周方向ストレインは拡張型心筋症の心不全患者の予後予測に寄与する。, 国内会議
    口頭発表（一般）

  • Association of Left Ventricular Myocardial Early Diastolic Motion with Long-Term Outcome in Patients with Pulmonary Hypertension
    Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Takuma Sawa, Yoshiki Yamadori, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Tetsuari Onishi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    第77回 日本循環器学会学術集会, 2013年03月, 英語, 日本循環器学会, 横浜, 2次元スペックルトラッキング法により左室短軸像乳頭筋レベルの拡張早期のCircumferencial strain rateを用いて肺高血症患者の予後を推定しえた。また、同指標は右室収縮能・左室拡張指標とも相関した。, 国内会議
    ポスター発表

  • 肝硬変及び難治性心不全を呈した高齢Ebstein奇形に対して、外科的治療が奏効した一例
    松本 賢亮, 今西 純一, 田中 秀和, 城戸 佐知子, 川合 宏哉, 平田 健一
    第15回 日本成人先天性心疾患学会, 2013年01月, 日本語, 日本成人先天性心疾患学会, 東京, Ebstein奇形を合併したTRにドブタミン負荷エコーが右室機能を評価するのに有用であった。, 国内会議
    ポスター発表

  • Feature of Mechanical Left Ventricular Dyssynchrony in Heart Failure Patients with "Very" Narrow QRS Duration: Using Three-dimensional Speckle-tracking Study
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, narrow QRSの心不全患者においても左室同期不全が存在することを報告した, 国際会議
    ポスター発表

  • Dynamic Left Ventricular Dyssynchrony Assessed by Three-Dimensional Speckle-Tracking Area Strain during Dobutamine Stress Has a Negative Impact on Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, ドブタミン投与下で評価した左室同期不全は動的に変化する。この左室同期不全の増悪は、拡張型心筋症の患者の予後と関係する。この事実は拡張型心筋症患者の予後評価に寄与する可能性がある。, 国際会議
    口頭発表（一般）

  • Correlation between Right Arterial Pressure and Right Arterial Volume Index in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Yoshiki Motoji, Keiko Ryo, Takuma Sawa, Yasuhide Mochizuki, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, Non-invasively assessed right arterial volume was associated with right atrial pressure by hemodynamic measurement in PH patients., 国際会議
    ポスター発表

  • Contractile Reserve Assessed by Three-Dimensional Global Circumferential Strain as a Predictor of Cardiovascular Events in Patients with Idiopathic Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, 3次元ドブタミン負荷心エコー図検査で評価した、円周方向ストレインは拡張型心筋症の心不全患者の予後予測に寄与する。, 国際会議
    口頭発表（一般）

  • Acute Reduction in Strain Dyssynchrony Index with Cardiac Resynchronization Therapy Predicts Mid-Term Left Ventricular Reverse-remodeling and Long-Term Outcome: Using Two-dimensional Speckle-tracking Study
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Takuma Sawa, Yasuhide Mochizuki, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, 心臓再同期療法によるStrain Dyssynchrony Indexの急性期減少が治療後の長期予後を予測することを報告した, 国際会議
    口頭発表（一般）

  • Ability of Right Ventricular Free Wall Longitudinal Speckle-Tracking Strain for Predicting Long-term Outcome in Patients with Pulmonary Hypertension
    Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Takuma Sawa, Junichi Imanishi, Tatsuya Miyoshi, Yasuhide Mochizuki, Mana Hiraishi, Akihiro Kaneko, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2012, 2012年11月, 英語, American Heart Association, Los Angeles, CA, 右室自由壁のLongitudinalの2次元スペックルトラッキング法を用いて肺高血症患者の予後を推定しえた。また同指標に右室収縮機能の指標であるTAPSEを加えることにより精度が増すことも報告した。, 国際会議
    口頭発表（一般）

  • Evaluation of Left Ventricular Function and Mechanical Dyssynchrony: Using Three-dimensional Speckle-tracking Strain
    Kazuhiro Tatsumi, Hidekazu Tanaka, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    The 5th Asia Pacific Heart Rhythm Society Scientific Session, 2012年10月, 英語, Asia Pacific Heart Rhythm Society, Tipei, Tiwan, 三次元スペックルトラッキング法を用いた左室同期不全についてreviewした, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • 肺動脈性高血圧症患者の長期予後予測における右室自由壁スペックルトラッキング法の有用性
    元地 由樹, 田中 秀和, 福田 優子, 漁 恵子, 今西 純一, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 川合 宏哉, 平田 健一
    第60回 日本心臓病学会学術集会, 2012年09月, 日本語, 日本心臓病学会, 金沢, 右室自由壁のLongitudinalの2次元スペックルトラッキング法を用いて肺高血症患者の予後を推定しえた。, 国内会議
    口頭発表（一般）

  • Comparison of Left Atrial Size Measured by Various Echocardiographic Approaches with That Measured by Multidetector Computed Tomography
    Keiko Ryo, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    American Society of Echocardiography 23th Annual Scientific Session, 2012年07月, 英語, American Society of Echocardiography, Washington, DC, 3D心エコー図検査と心臓CTで左房の径、容積等を比較検討した, 国際会議
    ポスター発表

  • Efficacy of Right Ventricular Free Wall Longitudinal Speckle-Tracking Strain for Predicting Long-term Outcome in Patients with Pulmonary Hypertension
    Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    American Society of Echocardiography 23th Annual Scientific Session, 2012年06月, 英語, American Society of Echocardiography, Washington, DC, 右室自由壁のLongitudinalの2次元スペックルトラッキング法を用いて肺高血症患者の予後を推定しえた。, 国際会議
    ポスター発表

  • 多発性の大動脈縮窄症を合併した大動脈二尖弁の一例
    沖 都麦, 田中 秀和, 松本 賢亮, 漁 恵子, 山本 哲志, 今西 孝充, 林 伸英, 河野 誠司, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, 大動脈二尖弁に合併した大動脈縮窄症の1例を症例報告した, 国内会議
    ポスター発表

  • 心臓再同期療法前と施行急性期における左室同期不全の指標を用いた長期予後の検討
    今西 純一, 田中 秀和, 松本 賢亮, 辰巳 和宏, 辻 隆之, 金子 明弘, 漁 恵子, 吉田 明弘, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, 【目的】心臓再同期療法（CRT）の効果を予測する際には、CRT前の左室dyssynchronyの評価が検討されてきたが、単一の指標のみでは十分ではない。一方、CRT植え込み後急性期の左室dyssynchronyの指標とCRTの効果を検討した研究は少ない。本研究の目的は、CRT施行急性期における左室dyssynchronyの改善と長期予後との関係、またCRT前の左室dyssynchronyの指標とCRT施行急性期におけるその改善度を組み合わせる事で、CRTの長期予後をより正確に予測できるかどうかを検討することである。【方法】CRTを施行した重症心不全患者121例（平均左室駆出率27±6%、平均QRS幅164±24ms、虚血性心疾患30例）を対象として、CRT前とCRT施行急性期（7±3日後）に心エコー図検査を施行した。左室dyssynchronyは2次, 国内会議
    口頭発表（一般）

  • 心臓再同期療法における左室形態と機能性僧帽弁閉鎖不全症の関係
    田中 秀和, 松本 賢亮, 辰巳 和宏, 平石 真奈, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, CRT]患者に合併する僧帽弁閉鎖不全症のメカニズムを奉公した, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 左室駆出率が保たれたアントラサイクリン系薬剤使用症例における左室心内膜機能障害
    三好 達也, 田中 秀和, 松本 賢亮, 金子 明弘, 辻 隆之, 漁 恵子, 辰巳 和宏, 南 博信, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, 左室全体の機能が保たれるが、アントラサイクリン系薬剤使用により左室心内膜障害が認められることが、3次元スペックルトラッキング法によるArea strainを用いて観察された, 国内会議
    口頭発表（一般）

  • Duchenne型筋ジストロフィーにおける機能的僧帽弁閉鎖不全症と左房径の関係について
    山本 哲志, 田中 秀和, 松本 賢亮, 漁 恵子, 今西 孝充, 林 伸英, 竹島 泰弘, 河野 誠司, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, Duchene型筋疾患患者に合併する僧帽弁閉鎖不全症のメカニズムを奉公した, 国内会議
    口頭発表（一般）

  • 3次元スペックルトラッキング法を用いた左室同期不全評価－wideからnarrow QRSまで－
    辰巳 和宏, 田中 秀和, 松本 賢亮, 辻 隆之, 金子 明弘, 漁 恵子, 吉田 明弘, 川合 宏哉, 平田 健一
    第85回 日本超音波医学会学術集会, 2012年05月, 日本語, 日本超音波医学会, 東京, wide QRS患者に多い左室同期不全がnarrow QRS患者にも存在することを報告した, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 肺高血症患者における右室2次元スペックルトラッキング法の有用性
    福田 優子, 田中 秀和, 漁 恵子, 元地 由樹, 今西 純一, 平石 真奈, 三好 達也, 金子 明弘, 辻 隆之, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 二次元スペックルトラッキング法により算出された右室自由壁ストレインは肺高血圧症患者において非侵襲的な指標になりうる。, 国内会議
    口頭発表（一般）

  • 心房細動患者における左房機能と肺静脈リモデリングの関係
    漁 恵子, 田中 秀和, 元地 由樹, 今西 純一, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 福田 優子, 辰巳 和宏, 松本 賢亮, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 肺静脈波形による左房機能と肺静脈拡大の心房細動発症への関与を検討した, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 急性の経過を呈した心サルコイドーシスの一例
    今西 純一, 田中 秀和, 松本 賢亮, 元地 由樹, 平石 真奈, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 福田 優子, 辰巳 和宏, 吉田 明弘, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 【症例】66歳男性。既往歴に糖尿病がある。2011年9月12日に呼吸困難が出現し、胸部X線にて肺うっ血を認め、急性心不全の診断で近医入院となった。しかし、酸素吸入とカテコラミンや利尿剤の持続投与を行うも、症状や心機能の改善は認められなかったため、9月21日に当院に転院となった。当院入院時は左室拡張末期径52mm、左室収縮末期径46mm、左室駆出率は25％と左室収縮能は高度に障害されていた。びまん性の左室壁障害を認め、壁の菲薄化や瘤などは認められなかった。冠動脈に有意狭窄はなかった。また、右室心筋から非乾酪性類上皮細胞肉芽腫の所見が得られ、心臓MRIでは心室中隔の右室側、前部中隔接合部～右室および左室下壁にかけて遅延造影が認められた。以上の結果から心サルコイドーシスと診断した。FDG-PETでは、前後部中隔接合部、左室側壁、および右室の一部でFDGの集, 国内会議
    口頭発表（一般）

  • 急激に悪化した小児ミトコンドリア心筋症の一例
    林 繭子, 田中 秀和, 山本 哲志, 李 知子, 粟野 宏之, 松本 賢亮, 今西 孝充, 林 伸英, 竹島 泰弘, 河野 誠司, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 3か月の経過で急激に心機能が低下した稀な小児のミトコンドリア心筋症の症例を報告した, 国内会議
    口頭発表（一般）

  • 右室スペックルトラッキング法による肺高血圧症患者の長期予後予測の検討
    元地 由樹, 田中 秀和, 福田 優子, 漁 恵子, 今西 純一, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 辰巳 和宏, 松本 賢亮, 江本 憲昭, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 右室自由壁のLongitudinalの2次元スペックルトラッキング法を用いて肺高血症患者の予後を推定しえた。, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • Nuclear IGF-1R expression as a prognostic factor in cervical cancer patients
    Tanioka M, Sudo T, Sakuma T, Obayashi C, Matsumoto K, Fujiwara K, Negoro S, Minami H
    Am Association for Cancer Res 2012, 2012年04月, 英語, Am Association for Cancer Res, Chicago, Nuclear IGF-1R expression as a prognostic factor in cervical cancer patients, 国際会議
    ポスター発表

  • Contractile Reserve by Three-Dimensional Global Circumferential Strain can Predict Outcome in Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Keni-chi Hirata
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, Contractile Reserve by Three-Dimensional Global Circumferential Strain can Predict Outcome in Dilated Cardiomyopathy, 国内会議
    口頭発表（一般）

  • Acute Effects of Adaptive Servo-Ventilation Therapy on Left Ventricular Regional Myocardial Function
    Mana Hiraishi, Hidekazu Tanaka, Junichi Imanishi, Yoshiki Motoji, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Masayuki Nakagawa, Asumi Takei, Hiroya Kawai, Ken-ichi Hirata
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, Acute Effects of Adaptive Servo-Ventilation Therapy on Left Ventricular Regional Myocardial Function, 国内会議
    口頭発表（一般）

  • 2次元スペックルトラッキング法が心臓再同期療法の適応に有用であった右脚ブロック型wide QRSの1症例
    今西 純一, 田中 秀和, 松本 賢亮, 元地 由樹, 平石 真奈, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 福田 優子, 辰巳 和宏, 吉田 明弘, 川合 宏哉, 平田 健一
    第23回 日本心エコー図学会学術集会, 2012年04月, 日本語, 日本心エコー図学会, 大阪, 右脚ブロック型のwide QRS症例は、左脚ブロック型の症例と比較して心臓再同期療法（CRT）により心機能が改善する確率が低く、その適応を見極めるのは容易ではない。今回2次元スペックルトラッキング法がCRTの適応に有用であった右脚ブロック型wide QRSの症例を提示する。78歳男性。虚血性心筋症にて内服加療をされていたが、心不全による入退院を繰り返していた。NYHAはIII°、心電図はQRS幅140msの完全右脚ブロックを呈しており、左室駆出率は23％と高度に低下していた。2次元スペックルトラッキング法による、左室短軸像心室中部レベルの前部中隔と後壁のpeak radial strainの時間差が425ms（≧130ms）と有意な左室のmechanical dyssynchronyを認めたため、CRTを施行した。CRT施行1週間後には左室駆出率は2, 国内会議
    口頭発表（一般）

  • Utility of Combined Assessment of Baseline Dyssynchrony and Its Acute Improvement to Predict Long-Term Outcome after Cardiac Resynchronization Therapy
    Junichi Imanisni, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Yoshiki Motoji, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Katsunori Okajima, Mitsuhiro Yokoyama, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    American College of Cardiology Scientific Session 2012, 2012年03月, 英語, American College of Cardiology, シカゴ, 米国, 国際会議
    ポスター発表

  • Subendocardial Dysfunction in Patients with Chronic Severe Aortic Regurgitation and Preserved Ejection Fraction Using Speckle-Tracking Strain and Transmural Strain Profile
    Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Junichi Imanishi, Yoshiki Motoji, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    口頭発表（一般）

  • Left Ventricular Mechanical Dyssynchrony in Heart Failure Patients with "Very" Narrow QRS Duration: Using Three-dimensional Speckle-tracking Study
    Kazuhiro Tatsumi, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    口頭発表（一般）

  • Left Ventricular Dyssynchrony as a Determinant of Torsional Mechanics in Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Kenichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    口頭発表（一般）

  • Impact of Left Ventricular Dyssynchrony on Cardiac Sympathetic Activity in Heart Failure Patients Following Cardiac Resynchronization Therapy
    Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Junichi Imanishi, Yoshiki Motoji, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Mayumi Shigeru, Sei Fujiwara, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    口頭発表（一般）

  • Evaluation of Left Ventricular Filling Pressures Using Tissue Doppler Derived Myocardial Acceleration During Isovolumic Contraction
    Alaa Mabrouk, Salem Omar, Hidekazu Tanaka, Kensuke Matsumoto, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    American College of Cardiology Scientific Session 2012, 2012年03月, 英語, American College of Cardiology, シカゴ, 米国, 国際会議
    ポスター発表

  • Detection of Subclinical Myocardial Dysfunction in Patients with Sarcoidosis Using Three-Dimensional Speckle Tracking Strain
    Takayuki Tsuji, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ich Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 日本語, 日本循環器病学会, 福岡, 国際会議
    ポスター発表

  • Comparison of Left Atrial Size Measured by Various Echocardiographic Approaches with That Measured by Multidetector Computed Tomography
    Keiko Ryo, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    ポスター発表

  • Association of Acute Reduction in Strain Dyssynchrony Index with Mid-Term Left Ventricular Reverse Remodeling and Long-Term Outcome after Cardiac Resynchronization Therapy
    Kazuhiro Tatsumi, Hidekazu Tanaka, Motoji Yoshiki, Imanishi Junichi, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 英語, 日本循環器病学会, 福岡, 国際会議
    口頭発表（一般）

  • Association of Acute Improvement in Left Ventricular Dyssynchrony with Long-Term Outcome after Cardiac Resynchronization Therapy
    Junichi Imanisni, Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Yoshiki Motoji, Tatsuya Miyoshi, Mana Hiraishi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Katsunori Okajima, Mitsuhiro Yokoyama, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 日本語, 日本循環器病学会, 福岡, 国際会議
    ポスター発表

  • Acute Effects of Adaptive Servo-Ventilation Therapy on Left Ventricular Regional Myocardial Function in Heart Failure Patients
    Mana Hiraishi, Hidekazu Tanaka, Junichi Imanishi, Yoshiki Motoji, Tatsuya Miyoshi, Takayuki Tsuji, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    第76回日本循環器病学会学術集会, 2012年03月, 日本語, 日本循環器病学会, 福岡, 国際会議
    ポスター発表

  • Ability of Contractile Reserve Assessed by Three-Dimensional Global Circumferential Strain as a Predictor of Long-Term Outcome in Patients with Idiopathic Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Yoshiki Motoji, Junichi Imanishi, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Keni-chi Hirata
    American College of Cardiology Scientific Session 2012, 2012年03月, 英語, American College of Cardiology, シカゴ, 米国, 国際会議
    ポスター発表

  • 当院で経験した大動脈四尖弁の4症例
    林 繭子, 田中 秀和, 山本 哲志, 漁 恵子, 松本 賢亮, 今西 孝充, 林 伸英, 川合 宏哉, 河野 誠司, 平田 健一
    日本超音波医学会 第39回関西地方会学術集会, 2011年11月, 日本語, 日本超音波医学会, 大阪, 国内会議
    口頭発表（一般）

  • 初回手術から11年後に発症したステントレス生体弁機能不全による急性大動脈弁閉鎖不全症の1例
    高橋 英樹, 田中 秀和, 松本 賢亮, 漁 恵子, 辻 隆之, 金子 明弘, 平石 真奈, 大北 裕, 川合 宏哉, 平田 健一
    日本超音波医学会 第39回関西地方会学術集会, 2011年11月, 日本語, 日本超音波医学会, 大阪, 国内会議
    口頭発表（一般）

  • 一酸化炭素中毒を契機に一過性の壁運動異常を呈した1 例
    元地 由樹, 田中 秀和, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 漁 恵子, 松本 賢亮, 川合 宏哉, 平田 健一
    日本超音波医学会 第39回関西地方会学術集会, 2011年11月, 日本語, 日本超音波医学会, 大阪, 国内会議
    口頭発表（一般）

  • ステロイドが奏功した抗ミトコンドリアM2抗体関連多発性筋炎に合併した慢性心筋炎の1例
    今西 純一, 田中 秀和, 松本 賢亮, 元地 由樹, 平石 真奈, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 福田 優子, 辰巳 和宏, 川合 宏哉, 平田 健一
    第112回日本循環器病学会近畿地方会, 2011年11月, 日本語, 日本循環器病学会, 京都, 国内会議
    口頭発表（一般）

  • Utility of Three-Dimensional Speckle Tracking Radial Strain for Identifying Patients with Cardiac Sarcoidosis
    Takayuki Tsuji, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ich Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    ポスター発表

  • Regional Heterogeneity of Systolic Dysfunction Leads to Ventricular Dyssynchrony in Patients with Idiopathic Dilated Cardiomyopathy and Narrow QRS Complex; 3-Dimensional Speckle-Tracking Strain Analysis
    Kensuke Matsumoto, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    口頭発表（一般）

  • Multidirectional Left Ventricular Performance Using Three-Dimensional Speckle-Tracking Strain in Patients with Chronic Right Ventricular Pacing and Preserved Ejection Function
    Hidekazu Tanaka, Kensuke Matsumoto, Kazuhiro Tatsumi, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    口頭発表（一般）

  • Left Ventricular Dyssynchrony as a Determinant of Torsional Mechanics in Patients with Dilated Cardiomyopathy
    Kensuke Matsumoto, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Hiroya Kawai, Keni-chi Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    ポスター発表

  • Endocardial Dysfunction in Patients with Chronic Aortic Regurgitation and Preserved Ejection Fraction
    Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Mana Hiraishi, Tatsuya Miyoshi, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    ポスター発表

  • Ability of Comprehensive Assessment of Strain Dyssynchrony Index by Speckle Tracking Imaging to Predict Long-Term Outcome after Cardiac Resynchronization Therapy in Patients with Heart Failure
    Kazuhiro Tatsumi, Hidekazu Tanaka, Tatsuya Miyoshi, Mana Hiraishi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association Scientific Session 2011, 2011年11月, 英語, American Heart Association, シカゴ, 米国, 国際会議
    ポスター発表

  • 心臓再同期療法における3次元スペックルエリアトラッキング法の有用性
    辰巳 和宏, 田中 秀和, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 漁 恵子, 山脇 康平, アレ オマール, 福田 優子, 則定 加津子, 松本 賢亮, 吉田 明弘, 川合 宏哉, 平田 健一
    第59回日本心臓病学会学術集会, 2011年09月, 日本語, 日本心臓病学会, 神戸, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 左室駆出率の低下したnarrow QRS心不全患者にも左室同期不全は存在する −3次元スペックルトラッキング法を用いた検討−
    辰巳 和宏, 田中 秀和, 三好 達也, 平石 真奈, 辻 隆之, 金子 明弘, 漁 恵子, 山脇 康平, アレ オマール, 福田 優子, 則定 加津子, 松本 賢亮, 川合 宏哉, 平田 健一
    第59回日本心臓病学会学術集会, 2011年09月, 日本語, 日本心臓病学会, 神戸, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 抗ミトコンドリアM2抗体関連多発性筋炎に合併した慢性心筋炎の1例
    三好 達也, 田中 秀和, 山名 祥太, 松本 賢亮, 平石 真奈, 金子 明弘, 辻 隆之, 漁 恵子, 福田 優子, 辰巳 和宏, 川合 宏哉, 平田 健一
    第59回日本心臓病学会学術集会, 2011年09月, 日本語, 日本心臓病学会, 神戸, 国内会議
    ポスター発表

  • Reverse remodeling induces progressive resynchronization after cardiac resynchronization therapy: from vicious to virtuous cycle
    松本賢亮, Kensuke Matsumoto, Hidekazu Tanaka, 田中秀和, 福田優子, Yuko Fukuda, Kazuko Norisada, 則定加津子, 辰巳和宏, Kazuhiro Tatsumi, Katsunori Okajima, 岡島克則, 林孝俊, Takatoshi Hayashi, Teishi Kajiya, 梶谷定志, 川合宏哉, Hiroya Kawai, Ken-ichi Hirata, 平田健一
    European Society of Cardiology National Meeting 2011, 2011年08月, 英語, European Society od cardiology, パリ, フランス, 国際会議
    口頭発表（一般）

  • カルチノイド症候群に合併した高度肺動脈弁閉鎖不全症および三尖弁閉鎖不全症の1症例
    三好達也, 田中秀和, 則定加津子, 平石真奈, 辻隆之, 金子明弘, 漁恵子, 山脇康平, 福田優子, 辰巳和宏, 松本賢亮, 大北裕, 川合宏哉, 平田健一
    第111回日本循環器病学会近畿地方会, 2011年06月, 日本語, 日本循環器病学会, 神戸, 国内会議
    口頭発表（一般）

  • Multidirectional Left Ventricular Performance Using Three-Dimensional Speckle-Tracking Strain in Patients with Chronic Right Ventricular Pacing and Preserved Ejection Function
    田中秀和, 辰巳和宏, 松本賢亮, 平石真奈, 三好達也, 金子明弘, 辻隆之, 山脇康平, 漁恵子, 福田優子, 則定加津子, 川合宏哉, 平田健一
    American Society of Echocardiography National Meeting 2011, 2011年06月, 英語, American Society of Echocardiography, モントリオール, カナダ, 国際会議
    口頭発表（一般）

  • Impact of Left Ventricular Afterload on Left Ventricular Longitudinal Dyssynchrony in Patients with Severe Aortic Valve Stenosis
    山脇康平, Kohei Yamawaki, Hidekazu Tanaka, 田中秀和, 平石真奈, Mana Hiraishi, Tatsuya Miyoshi, 三好達也, 金子明弘, Akihiro Kaneko, Takayuki Tsuji, 辻隆之, 漁恵子, Keiko Ryo, Kazuko Norisada, 則定加津子, 福田優子, Yuko Fukuda, Kazuhiro Tatsumi, 辰巳和宏, 松本賢亮, Kensuke Matsumoto, Yutaka Okita, 大北裕, 川合宏哉, Hiroya Kawai, Ken-ichi Hirata, 平田健一
    American Society of Echocardiography National Meeting 2011, 2011年06月, 英語, American Society of Echocardiography, モントリオール, カナダ, 国際会議
    ポスター発表

  • 3次元経食道心エコー図が診断に有用であったUnicommissural Unicuspid Aortic Valve Stenosisの一例
    平石真奈, 田中秀和, 松本賢亮, 三好達也, 辻隆之, 金子明弘, 漁恵子, 山脇康平, 福田優子, 則定加津子, 辰巳和宏, 大北裕, 川合宏哉, 平田健一
    第111回日本循環器病学会近畿地方会, 2011年06月, 日本語, 日本循環器病学会, 神戸, 国内会議
    口頭発表（一般）

  • 卵円孔に血栓が陥入した急性肺動脈血栓症の一例
    三好達也, 田中秀和, 金子明弘, 辻隆之, 漁恵子, 山脇康平, 松本賢亮, 大北裕, 川合宏哉, 平田健一
    日本超音波医学会第84回学術集会, 2011年05月, 日本語, 日本超音波医学会, 東京, 国内会議
    ポスター発表

  • 心臓再同期療法における3次元スペックルトラッキング法の有用性
    田中秀和, 辰巳和宏, 松本賢亮, 金子明弘, 辻隆之, 漁恵子, 山脇康平, 則定加津子, 川合宏哉, 平田健一
    日本超音波医学会第84回学術集会, 2011年05月, 日本語, 日本超音波医学会, 東京, 国内会議
    口頭発表（一般）

  • 左心耳内血栓を合併した非細菌性血栓性心内膜炎の1例
    則定加津子, 田中秀和, 金子明弘, 辻隆之, 山脇康平, 漁恵子, 辰巳和宏, 松本賢亮, 川合宏哉, 平田健一
    日本超音波医学会第84回学術集会, 2011年05月, 日本語, 日本超音波医学会, 東京, 国内会議
    口頭発表（一般）

  • 虚血性心疾患の局所長軸機能におけるハンドグリップ及びドブタミン負荷の有用性
    漁 恵子, 田中 秀和, 金子 明弘, 辻 隆之, 山脇 康平, 則定 加津子, 辰巳 和宏, 松本 賢亮, 川合 宏哉, 平田 健一
    日本超音波医学会第84回学術集会, 2011年05月, 日本語, 日本超音波医学会, 東京, 国内会議
    口頭発表（一般）

  • 心サルコイドーシスの診断における3次元スペックルトラッキング法の有用性
    辻隆之, 田中秀和, 三好達也, 平石真奈, 金子明弘, 山脇康平, 漁恵子, 則定加津子, 福田優子, 辰巳和宏, 松本賢亮, 川合宏哉, 平田健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    ポスター発表

  • 左室正常壁運動のDuchenne型筋ジストロフィーにおけるradial strain中に見られたノッチの臨床的意義について
    山本哲志, 山本 哲志, 川合 宏哉, 平石 真奈, 平石 真奈, 三好 達也, 辻 隆之, 辻 隆之, 金子 明弘, 金子 明弘, 漁 恵子, 漁 恵子, 山脇 康平, 山脇 康平, 福田 優子, 辰巳 和宏, 辰巳 和宏, 則定 加津子, 則定 加津子, 松本 賢亮, 田中 秀和, 林伸英, 林 伸英, 木下 承晧, 木下承晧, 竹島泰弘, 竹島 泰弘, 平田 健一, 松尾雅文, 松尾 雅文, 河野 誠司, 河野誠司
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    口頭発表（一般）

  • 高度三尖弁閉鎖不全と右室機能低下を伴ったEbstein奇形の術後の予後予測にドブタミン負荷心エコー法が有用であった1例
    平石 真奈, 田中 秀和, 松本 賢亮, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 山脇 康平, 福田 優子, 則定 加津子, 辰巳 和宏, 大北 裕, 川合 宏哉, 平田 健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    ポスター発表

  • 経胸壁心エコー図法を用いた大動脈弁置換術における適切な人工弁サイズの推測方法に関する検討
    嘉納由美子, 田中 秀和, 山本哲志, 平石 真奈, 三好 達也, 辻 隆之, 金子 明弘, 漁 恵子, 山脇 康平, 福田 優子, 辰巳 和宏, 則定 加津子, 松本 賢亮, 林伸英, 木下承晧, 河野誠司, 川合 宏哉, 平田 健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    ポスター発表

  • 拡張型心筋症における左室収縮能障害の不均一性と左室同期不全との関係 3D Speckle-Tracking 法を用いた定量化の試み
    松本賢亮, 田中秀和, 平石真奈, 三好達也, 金子明弘, 辻隆之, 漁恵子, 山脇康平, 福田優子, 則定加津子, 辰巳和宏, 川合宏哉, 平田健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    口頭発表（一般）

  • スペックルトラッキング法を用いた慢性大動脈弁閉鎖不全症患者における局所心筋機能評価の有用性
    金子 明弘, 田中 秀和, 大西 哲存, 三好 達也, 平石 真奈, 辻 隆之, 山脇 康平, 漁 恵子, 福田 優子, 則定 加津子, 辰巳 和宏, 松本 賢亮, 川合 宏哉, 平田 健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    口頭発表（一般）

  • カルチノイド症候群に合併した高度肺動脈弁閉鎖不全症および三尖弁閉鎖不全症の1症例
    岡崎葉子, 田中秀和, 則定加津子, 平石真奈, 三好達也, 辻隆之, 金子明弘, 漁恵子, 山脇康平, 福田優子, 辰巳和宏, 松本賢亮, 木下承晧, 河野誠司, 川合宏哉, 平田健一
    第22回日本心エコー図学会学術集会, 2011年04月, 日本語, 日本心エコー図学会, 鹿児島, 国内会議
    口頭発表（一般）

  • Usefulness of Right Ventricular Speckle Tracking Strain to Evaluate the Effect of Medical Treatment in Patients with Pulmonary Hypertension
    Yuko Fukuda, Hidekazu Tanaka, Keiko Ryo, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Kohei Yamawaki, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • The usefulness of longitudinal speckle tracking strain with handgrip stress to detect ischemic myocardial segments
    Keiko Ryo, Hidekazu Tanaka, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Kouhei Yamawaki, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 日本語, 日本循環器学会, 横浜, 国内会議
    ポスター発表

  • Regional Heterogeneity of Systolic Dysfunction Leads to Ventricular Dyssynchrony in Patients with Dilated Cardiomyopathy and Narrow QRS Complex Assessed by 3-Dimensional Speckle-Tracking Strain
    Kensuke Matsumoto, Hidekazu Tanaka, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Kohei Yamawaki, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Multidirectional Left Ventricular Performance Using Three-Dimensional Speckle-Tracking Strain in Patients with Chronic Right Ventricular Pacing and Preserved Ejection Function
    Hidekazu Tanaka, Kazuhiro Tatsumi, Kensuke Matsumoto, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Kouhei Yamawaki, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Left Ventricular Longitudinal Dyssynchrony in Patients with Severe Aortic Valve Stenosis
    Kohei Yamawaki, Hidekazu Tanaka, Mana Hiraishi, Tatsuya Miyoshi, Akihiro Kaneko, Takayuki Tsuji, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Kazuhiro Tatsumi, Kensuke Matsumoto, Yutaka Okita, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Impact of Left Ventricular Dyssynchrony on Cardiac Sympathetic Activity in Heart Failure Patients with Wide QRS Duration
    Hidekazu Tanaka, Kazuhiro Tatsumi, Sei Fujiwara, Mana Hiraishi, Tatsuya Miyoshi, Mayumi Shigeru, Akihiro Kaneko, Takayuki Tsuji, Kouhei Yamawaki, Keiko Ryo, Yuko Fukuda, Kazuko Norisada, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    第75回日本循環器学会総会・学術集会, 2011年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Regional Myocardial Systolic Function Using Transmural Myocardial Strain Profile Predicts Postoperative Left Ventricular Systolic Dysfunction in Chronic Aortic Regurgitation
    Akihiro Kaneko, Hidekazu Tanaka, Tetsuari Onishi, Takahiro Tsuji, Kohei Yamawaki, Keiko Ryo, Kazuhiro Tatsumi, Kensuke Matsumoto, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association 2010, 2010年11月, 英語, American Heart Association, シカゴ, アメリカ合衆国, 国際会議
    ポスター発表

  • Area Strain Dyssynchrony Index by Three-dimensional Speckle Tracking Imaging Predicts Left Ventricular Reverse Remodeling with Cardiac Resynchronization Therapy
    Kazuhiro Tatsumi, Hidekazu Tanaka, Takayuki Tsuji, Akihiro Kaneko, Kouhei Yamawaki, Keiko Ryo, Alaa M.S. Omar, Kensuke Matsumoto, Akihiro Yoshida, Hiroya Kawai, Ken-ichi Hirata
    American Heart Association 2010, 2010年11月, 英語, American Heart Association, シカゴ, アメリカ合衆国, 国際会議
    ポスター発表

  • 卵円孔に血栓が陥入した急性肺血栓塞栓症の一例
    三好 達也, 田中 秀和, 金子 明弘, 辻 隆之, 漁 恵子, 山脇 康平, 松本 賢亮, 大北 裕, 平田 健一, 川合 宏哉
    日本超音波医学会 第37回関西地方会学術集会, 2010年10月, 日本語, 日本超音波医学会, 神戸, 国内会議
    口頭発表（一般）

  • 心エコー図検査が治療方針決定に有用であった左室流出路狭窄の2症例
    加納 由美子, 田中 秀和, 辻 隆之, 金子 明弘, 漁 恵子, 山脇 康平, 松本 賢亮, 大北 裕, 平田 健一, 川合 宏哉
    日本超音波医学会 第37回関西地方会学術集会, 2010年10月, 日本語, 日本超音波医学会, 神戸, 国内会議
    口頭発表（一般）

  • 重症三尖弁閉鎖不全に対して三尖弁形成術を行い、良好な結果を得た高齢Ebstein奇形の一例
    平石 真奈, 田中 秀和, 松本 賢亮, 金子 明弘, 辻 隆之, 漁 恵子, 山脇 康平, 大北 裕, 平田 健一, 川合 宏哉
    日本超音波医学会 第37回関西地方会学術集会, 2010年10月, 日本語, 日本超音波医学会, 神戸, 国内会議
    口頭発表（一般）

  • Löffler’s endocarditis with severely impaired left ventricular function and thrombus
    辻 隆之, 田中 秀和, 金子 明弘, 漁 恵子, 山脇 康平, 松本 賢亮, 川合 宏哉, 平田 健一
    第14回日本心不全学会学術集会, 2010年10月, 日本語, 日本心不全学会, 東京, 国内会議
    ポスター発表

  • 重症大動脈弁狭窄症における左室同期不全と左室後負荷の関係
    山脇 康平, 川合 宏哉, オマール アレ, 金子 明弘, 辻 隆之, 漁 恵子, 則定 加津子, 辰巳 和宏, 松本 賢亮, 大西 哲存, 田中 秀和, 大北 裕, 平田 健一
    第58回日本心臓病学会学術集会, 2010年09月, 日本語, 日本心臓病学会, 東京, 国内会議
    ポスター発表

  • 左室内に巨大な血栓を認めたレフレル心内膜炎の1症例
    辻 隆之, 松本 賢亮, 社 隆嗣, 川合 宏哉, 平田 健一
    第109回日本循環器学会近畿地方会, 2010年06月, 日本語, 日本循環器学会, 大阪, 国内会議
    口頭発表（一般）

  • 特異な心エコー図所見を呈したレフレル心内膜炎の1例
    金子明弘, 川合宏哉, 辻 隆之, 漁 恵子, 山脇康平, 則定加津子, 辰巳和宏, 松本賢亮, 大西哲存, 平田健一
    日本超音波医学会第83回学術集会, 2010年05月, 日本語, 日本超音波医学会, 京都, 国内会議
    口頭発表（一般）

  • 重症大動脈弁狭窄症における左室同期不全と左室後負荷の関係
    山脇 康平, 川合 宏哉, オマール アレ, 金子 明弘, 辻 隆之, 漁 恵子, 則定 加津子, 辰巳 和宏, 松本 賢亮, 大西 哲存, 田中 秀和, 大北 裕, 平田 健一
    第21回日本心エコー図学会学術集会, 2010年05月, 日本語, 日本心エコー図学会, 北海道, 国内会議
    ポスター発表

  • 虚血性心疾患におけるハンドグリップ負荷2D speckle tracking心エコー図法の有用性
    漁 恵子, 川合 宏哉, 辻 隆之, 金子 明弘, 山脇 康平, 則定 加津子, 辰巳 和宏, 松本 賢亮, 田中 秀和, 平田 健一
    第21回日本心エコー図学会学術集会, 2010年05月, 日本語, 日本心エコー図学会, 札幌, 国内会議
    口頭発表（一般）

  • 拡張型心筋症における左室収縮能障害の不均一性と左室同期不全との関係 -Real-time 3D 心エコー図法を用いた検討-
    松本 賢亮, 川合 宏哉, 金子 明弘, 辻 隆之, 山脇 康平, 漁 恵子, アレ オマール, 福田 優子, 則定 加津子, 辰巳 和宏, 大西 哲存, 田中 秀和, 平田 健一
    第21回日本心エコー図学会学術集会, 2010年05月, 日本語, 日本心エコー図学会, 北海道, 国内会議
    ポスター発表

  • ピモベンダンが有効であった心サルコードーシスによる難治性心不全の1例
    辻 隆之, 川合 宏哉, 金子 明弘, 漁 恵子, 山脇 康平, アレ・オマール, 則定 加津子, 辰巳 和宏, 松本 賢亮, 大西 哲存, 田中 秀和, 平田 健一
    日本超音波医学会第83回学術集会, 2010年05月, 日本語, 日本超音波医学会, 京都, 国内会議
    口頭発表（一般）

■ 共同研究・競争的資金等の研究課題
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