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片岡 洋祐大学院科学技術イノベーション研究科 科学技術イノベーション専攻教授
研究活動情報
■ 受賞- 2007年 日本レーザー治療学会研究奨励賞日本国
- 2005年 日本組織細胞化学会若手研究奨励賞日本国
- 2004年 フロンティアレーザー医学賞日本国
- 1996年 井上研究奨励賞日本国
- Cytochemistry
- 1st Award for excellent articles in Japan Society of Histochemistry and
- 13th Inoue Research Award for Young Scientists
- 2000年07月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 273(2) (2), 637 - 641, 英語
- 2000年, European Journal of Neuroscience, 12(12) (12), 4417 - 4423, 英語
- Academic Press Inc., 1999年11月19日, Biochemical and Biophysical Research Communications, 265(2) (2), 301 - 304, 英語
- 1999年09月, European Journal of Neuroscience, 11(9) (9), 3115 - 3124, 英語
- To elucidate the steroid-synthesis in the mammalian brain (i. e., neurosteroid), we immunohistochemically studied various kinds of steroidogenic cytochrome P450 enzymes in the rat brain. The primary antibodies used in this study were rabbit polyclonal antibodies to cholesterol side-chain cleavage (SCC), C21-hydroxylase (C21), 11β-hydroxylase (11β), 17α-hydroxylase/C17-20 lyase (17α) and aromatase (AROM). The immunoreactivities for the microsome enzymes, C21 and 17α were located in the neuronal cell-bodies and proximal parts of their fibers, while mitochondria enzymes, SCC and 11β were located in the cell-bodies and their fibers and terminals. These immunoreactivities were distributed in the limbic structures of prosencephalon including hippocampus and amygdaloid complex, the hypothalamus including preoptic area, the cerebellar cortex, and some of other regions. All the sets of these enzymes did not always coexist in the identical cells, however, in the hypothalamus and cerebellum these enzymes are thought to work one after another in adjacent cells, forming the "steroidogenic cellular circuits". These findings strongly suggest that the steroidsynthesis occurs in the neurons; and the neurosteroids exist in the mammalian brain.JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY, 1997年10月01日, Acta histochemica et cytochemica, 30(5) (5), 609 - 616, 英語
- Journal of Neurophysiology 76, 1996, 1870-1879Of known neurotransmitters, glutamate is the most likely to be released from chick cochlear hair cells
- Neuroscience 92, 1999, 1061-1077
- Journal of Anatomy 188, 1996, 375-381Cell proliferation and renewal of mouse adrenal cortex
- Biomedical Research 15, Supplement 1, 1994, 47-49Afferent synaptic transmission in hair cells
- Journal of Physiology (London) 477, 1994, 403-414Activation of glutamate receptors in response to membrane depolarization of hair cells isolated from chick cochlea
- The Journal of Neuroscience 17, 1997, 7017-7024A postsynaptic excitatory amino acid transporter with chloride conductance functionally regulated by neuronal activity in cerebellar Purkinje cells
- 日本レーザー治療学会
- 日本組織細胞化学会
- 日本生理学会
- 日本疲労学会
- 日本神経科学会
- 北米神経科学会
- Society for Neuroscience
- Physiological Society of Japan
- Japan Neuroscience Society