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寺井 義人大学院医学研究科 医科学専攻教授
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■ 論文- BACKGROUND: Comprehensive genomic profiling (CGP) has been used to identify mutations in several hundred cancer-related genes. Patients may receive treatment that targets specific genetic mutations revealed by CGP. This study aimed to investigate the usefulness of CGP in gynecologic malignancies. METHODS: Hospital records including CGP and clinical information were reviewed from 20 institutions in the Kinki District of Japan for patients with gynecological malignancies who underwent CGP. RESULTS: A total of 724 patients were included, of whom 162 had cervical cancer, 157 had endometrial cancer, 327 had ovarian cancer, 29 had other cancers, and 49 had sarcomas. Actionable gene alterations were identified in 370 (51.1%). The most commonly altered genes were PIK3CA (14.4%), high loss of heterozygosity (12.4%), and high tumor mutation burden (10.9%). Matched therapy, based on actionable gene alterations, was administered to 73 patients (10.1%). Of these, 23 patients received matched therapy for a high tumor mutation burden, 10 for high microsatellite instability and BRCA1/2, six for ERBB2, and five for PIK3CA. Twenty-five patients died before receiving their CGP results. The objective response and disease control rates were 23.6% and 41.8%, respectively. Of the 122 patients to whom genetic counseling was recommended, 68 accepted. CONCLUSIONS: CGP testing for gynecological malignancies in Japan may improve therapeutic efficacy. However, several issues remain to be addressed, including the low matched therapy rate and death prior to availability of CGP test results.2025年07月, International journal of clinical oncology, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVE: Essential thrombocythemia (ET), a life-threatening disease, is associated with increased risks of hemorrhagic and thromboembolic complications. In particular, ET during pregnancy is rare and associated with an increased risk of obstetric complications. Drug therapies are frequently administered for managing pregnant women with ET, and plateletpheresis is considered to reduce platelet (PLT) counts rapidly. CASE REPORT: A 28-year-old pregnant woman was referred to our hospital at 37 + 0/7 gestational weeks (GWs) due to severe thrombocythemia. She underwent plateletpheresis at 37 + 4/7 GWs because thrombocythemia was exacerbated. She delivered vaginally at 38 + 0/7 GWs without hemorrhagic or thromboembolic complications. She was diagnosed with ET based on a bone marrow biopsy, and ET gradually improved with medication. Thus, she and her baby were discharged without complications. CONCLUSION: Plateletpheresis is useful for preventing hemorrhagic and thromboembolic complications at delivery in pregnant women with ET and severe thrombocythemia during the antepartum period.2025年07月, Taiwanese journal of obstetrics & gynecology, 64(4) (4), 703 - 706, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The effectiveness of local treatment in lymph node metastasis from uterine cancer has been proven; the standard treatment is surgical intervention. Although radiotherapy, including particle radiotherapy (PRT), is an alternative local treatment, its application is often contraindicated owing to its proximity to the gastrointestinal tract. Combination treatment with spacer placement surgery followed by PRT is a potential solution to this problem. This study aimed to evaluate the outcomes of this combination treatment of lymph node metastases from uterine cancer. PATIENTS AND METHODS: Between December 2007 and March 2023, ten consecutive patients who underwent combination treatment comprising spacer placement surgery and subsequent PRT were assessed for treatment outcomes. RESULTS: The median survival time was 53.5 months; the 3- and 5-year overall survival rates were 76.2% and 38.1%, respectively. The 3- and 5-year local control rates in all patients were both 88.9%. The median volume irradiated at 95% of the treatment planning dose (V95%) of the gross tumor volume, clinical target volume, and planning target volume were 100.0%, 99.8%, and 92.2%, respectively. The median dose intensity covering 95% of the target volume (D95%) of the gross tumor volume/planned dose, clinical target volume/planned dose, and planning target volume/planned dose were 98.9%, 99.0%, and 87.2%, respectively. CONCLUSIONS: Spacer placement surgery contributed to the optimized PRT dose distribution and might have contributed to favorable local control and survival rates. This innovative combination treatment might have a significant effect on the treatment of lymph node metastases from uterine cancers.2025年06月, Annals of surgical oncology, 32(6) (6), 4313 - 4321, 英語, 国際誌研究論文（学術雑誌）
- Extrauterine choriocarcinoma is uncommon and may be mistaken for a ruptured ectopic pregnancy. Rapid diagnosis is essential, as massive intraperitoneal bleeding can be fatal. Once histologically diagnosed, choriocarcinoma is highly chemosensitive. This case describes a 38-year-old woman who presented with sudden lower abdominal pain. Six weeks after her last menstrual period, serum human chorionic gonadotropin (hCG) was 28,834 mIU/mL. No intra-uterine gestational sac was found, and intraperitoneal bleeding was observed, suggesting an ectopic pregnancy. An emergency laparoscopic surgery revealed a blood clot and active bleeding on the peritoneal surface near the ileocecal region, which was resected. Histology revealed sheets of syncytiotrophoblasts and intermediate trophoblast cells without villi, and immunohistochemistry was diffusely positive for Ki-67 and hCG, confirming primary peritoneal choriocarcinoma. Staging imaging revealed no other lesions. The patient received four cycles of MEA chemotherapy (methotrexate, etoposide, actinomycin D) at three-week intervals, resulting in sustained hCG normalization and no evidence of recurrence at follow-up. Primary peritoneal choriocarcinoma should be considered in the differential diagnosis of intraperitoneal bleeding during early pregnancy. Even when ectopic pregnancy is suspected, the excised tissue must be submitted for histopathological examination so that chemotherapy can be initiated promptly in case of choriocarcinoma.2025年06月, Cureus, 17(6) (6), e86529, 英語, 国際誌研究論文（学術雑誌）
- Primary hyperparathyroidism (PHPT) during pregnancy is rare, causing severe pregnancy complications. We report a pregnant woman with PHPT and a pregnancy complication history who underwent a single-gland parathyroidectomy during the second trimester and delivered at term. A 28-year-old pregnant woman, gravida 3, para 2, was referred to our hospital at 9 gestational weeks (GWs) because of previous intrauterine fetal death, preterm birth, and fetal growth restriction. She was diagnosed with PHPT during her second pregnancy, and her baby experienced neonatal hypocalcemia. However, she received no PHPT treatment afterward. Laboratory tests and neck ultrasound revealed hyperparathyroidism and an enlarged right superior parathyroid gland. She underwent a right superior parathyroidectomy at 24 GWs. She delivered a 2,136 g (-1.74 SD) healthy female infant at 37 GWs, and her baby demonstrated no neonatal hypocalcemia. Parathyroidectomy, even during pregnancy, should be considered among pregnant women with PHPT having a pregnancy or neonatal complication history.2025年05月, The Kobe journal of medical sciences, 71(1) (1), E41-E45, 英語, 国内誌研究論文（学術雑誌）
- 2025年05月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 35(5) (5), 101787 - 101787, 英語, 国際誌
- The Japan Society of Gynecologic Oncology (JSGO) guideline for the treatment of uterine body neoplasm are revised from the 2018 guideline. This guideline aimed to provide standardized care for uterine body neoplasm, indicate appropriate current treatment methods for uterine body neoplasm, minimize variances in treatment methods among institutions, improve disease prognosis and treatment safety, reduce the economic and psychosomatic burden on patients by promoting the performance of appropriate treatment, and enhance mutual understanding between patients and healthcare professionals. The guidelines were prepared through the consensus of the JSGO guideline committee, based on a careful review of evidence from the literature searches and the medical health insurance system and actual clinical practice situations in Japan. The main features of the 2023 revision are as follows: 1) The Guidelines Formulation Committee members were asked to understand Minds' medical guideline development method in advance. 2) The clinical question (CQ) was changed to Patient, Intervention, Comparison, Outcome format as much as possible. 3) Introduced the "body of evidence," which summarizes the results of research reports collected for the CQs by outcome and study design, and the strength of evidence for each body of evidence was rated from levels A to D. 4) Introduction of systematic reviews in some CQs. 5) The strength of evidence, the balance of benefits and harms, value and hope for patients, and clinical applicability were considered while drafting recommendations. Herein, we present the English version of the JSGO guidelines 2023 for the treatment of uterine body neoplasm.2025年05月, Journal of gynecologic oncology, 36(3) (3), e119, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: The incidence and mortality rates of endometrial cancer are increasing globally, including in Japan. Quality of cancer care is promoted through guideline adherence. This study aimed to establish quality indicators (QIs) for endometrial cancer and explore the factors contributing to treatment nonadherence. METHODS: QIs and pattern-of-care indicators (PCIs) were developed using the Research and Development/University of California Los Angeles modified Delphi method. QIs reflect desirable healthcare patterns, whereas PCIs address treatment areas with lacking evidence. Data from the Hospital-Based Cancer Registry and Diagnosis Procedure Combination Survey were used. Patients diagnosed or treated between January 1 and December 31, 2020 were included. The reasons for nonadherence were collected. Logistic regression was used to analyze the factors influencing adherence, including age, body mass index, comorbidities, facilities, and recurrence risk. RESULTS: Of the 35 proposed QI candidates, 8 QIs and 9 PCIs were selected, predominantly focusing on surgical aspects. Adherence rates varied, with peritoneal lavage cytology being the highest (93.1%), and postoperative hormone replacement therapy (HRT) for patients aged <45 years being the lowest (30.9%), when focusing on process indicators. Reasons for nonadherence included patient preference and medical comorbidities as significant factors. Multivariate analysis highlighted age, clinical stage, and Barthel index as significant contributors to nonadherence. CONCLUSION: We developed QIs to comprehensively assess endometrial cancer treatment. Adherence rates are favorable; however, HRT has a low adherence rate. Factors leading to nonadherence include advanced age and incomplete activities of daily living, particularly in advanced stages.2025年03月, Journal of gynecologic oncology, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Ovarian cancer is asymptomatic in its early stages, and often diagnosed at advanced stages, leading to a high recurrence rate. In recent years, exosomes have been shown to be useful for early-detection, prognosis prediction, and treatment of cancer. Although many studies of cancer-related exosomes using other bodily fluids have been reported, there are few studies examining vaginal discharge, but none related to ovarian cancer. In this study, we investigated a method for early-detection of ovarian cancer using vaginal discharge, which are physically close to the fallopian tubes, where ovarian cancer originates, and can be easily collected from outside the body. MATERIALS AND METHODS: Vaginal discharge was collected from 30 patients with ovarian cancer and 29 patients with benign gynecological diseases, and exosomal miRNAs were extracted. Samples from each group were submitted to miRNA microarray in order to examine miRNAs with significant differences in expression levels. We further narrowed down the list to four miRNAs based on literature and microarray data and examined the expression levels of miRNAs in the malignant and benign groups by RT-qPCR. RESULTS: MiR-575 expression was significantly decreased in the malignant group compared to the benign group (p=0.00861). qPCR results were analyzed for several patient characteristics and no significant differences were found. CONCLUSION: This is the first study to investigate exosomal miRNAs in vaginal discharge of ovarian cancer. Exosomal miR-575 in vaginal discharge may be used as a biomarker for ovarian cancer.2025年, Cancer genomics & proteomics, 22(3) (3), 382 - 396, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Live broadcasting of robot-assisted surgeries has gained traction as a valuable educational tool offering real-time insights into surgical procedures. However, in Japan, legal restrictions and safety concerns have hindered the widespread adoption of live surgery. This study introduces a novel, modified online live-streaming system with a commentator to facilitate bidirectional discussions, addressing these limitations and enhancing surgical education. METHODS: A multi-institutional observational study was conducted using the Intuitive Telepresence system to broadcast da Vinci robotic surgeries. A commentator familiar with the surgeon's style facilitated real-time discussions with remote participants. A questionnaire using a 5-point Likert scale was used to assess usability, surgical comprehension, and bidirectional discussion. Statistical analyses were performed to compare satisfaction levels across different aspects of the system. RESULTS: Between November 2022 and September 2024, six live robotic surgery broadcasts were conducted, with 15 participants attending a total of 19 sessions. Most participants (94.7%) reported positive experiences with the bidirectional discussions, citing the commentator's role as crucial in explaining surgical decisions. The system was highly effective in conveying robotic instrument handling (94.7% rated 4 or higher) and anatomical understanding (94.7%). However, assistant operations and overall operating room dynamics received lower ratings, with 57.9% rating them as unsatisfactory. Early sessions experienced video quality issues, which improved with stable internet connections; later sessions achieved a 90% satisfaction rate. CONCLUSION: Our modified "commentator-based live streaming system" successfully facilitated bidirectional learning and improved robotic surgical education. We aim to expand the use of this live surgical broadcasting system across Japan.2025年, Asian journal of endoscopic surgery, 18(1) (1), e70072, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The Geriatric-8 (G8) is a validated screening tool for identifying frailty in elderly cancer patients. Although minimally invasive surgery (MIS) is increasingly performed in older adults with gynecologic malignancies, few studies have evaluated the association between G8 scores and perioperative complications in this setting. METHODS: This single-center retrospective study included patients aged ≥ 65 years who underwent MIS for gynecologic malignancies between January 2019 and March 2024. G8 scores were retrospectively calculated using medical records, with a threshold of ≤ 12.5 indicating geriatric risk. Perioperative complications were defined as either (1) Clavien-Dindo classification or CTCAE version 5 grade II or higher within 30 days postoperatively or (2) the need for rehabilitation intervention due to a decline in activities of daily living (ADL). Univariate and multivariate logistic regression analyses were conducted to identify associated factors. RESULTS: A total of 68 patients were included (median age: 72.5 years). The median G8 score was significantly lower in the complication group than in the non-complication group (12.5 vs. 14.5, p = 0.008). In multivariate analysis, a G8 score ≤ 12.5 was independently associated with perioperative complications (OR: 4.02, 95% CI: 1.38-11.70, p = 0.011). No significant associations were found for operative time, hysterectomy, or lymphadenectomy. CONCLUSION: A low G8 score was independently associated with perioperative complications and may be useful for preoperative risk assessment in elderly patients undergoing MIS for gynecologic malignancies.2025年, Asian journal of endoscopic surgery, 18(1) (1), e70098, 英語, 国内誌研究論文（学術雑誌）
- 2025年, Gynecology and minimally invasive therapy, 14(3) (3), 201 - 206, 英語, 国際誌研究論文（学術雑誌）
- AIMS/INTRODUCTION: This study aimed to evaluate the problems in screening for gestational diabetes mellitus (GDM) by casual blood glucose (CBG) measurements at 24-28 gestational weeks. MATERIALS AND METHODS: Overall, 763 pregnant women who underwent the 50-g glucose challenge test (GCT) at 24-28 gestational weeks were enrolled. The preload blood glucose (0-h BG) level of 50-g GCT was considered as CBG. RESULTS: A total of 240 women with BG levels at 1-h after loading (1-h BG) on 50-g GCT ≥140 mg/dL underwent the 75-g oral glucose tolerance test, and 98 (40.8%) were diagnosed with GDM. Of the 99 women with GDM, 71 (71.7%) had 0-h BG on 50-g GCT <100 mg/dL. CONCLUSIONS: This study, where pregnant women underwent both CBG and 50-g GCT simultaneously, showed that when CBG at 24-28 gestational weeks ≥100 mg/dL alone was used for screening GDM, many pregnant women with GDM were overlooked.2024年12月, Journal of diabetes investigation, 15(12) (12), 1797 - 1802, 英語, 国内誌研究論文（学術雑誌）
- Macrophages in the tumor microenvironment, termed tumor-associated macrophages (TAMs), promote the progression of various cancer types. However, many mechanisms related to tumor–stromal interactions in epithelial ovarian cancer (EOC) progression remain unclear. High-grade serous ovarian carcinoma (HGSOC) is the most malignant EOC subtype. Herein, immunohistochemistry was performed on 65 HGSOC tissue samples, revealing that patients with a higher infiltration of CD68+, CD163+, and CD204+ macrophages had a poorer prognosis. We subsequently established an indirect co-culture system between macrophages and EOC cells, including HGSOC cells. The co-cultured macrophages showed increased expression of the TAM markers CD163 and CD204, and the co-cultured EOC cells exhibited enhanced proliferation, migration, and invasion. Cytokine array analysis revealed higher YKL40 secretion in the indirect co-culture system. The addition of YKL40 increased proliferation, migration, and invasion via extracellular signal-regulated kinase (Erk) signaling in EOC cells. The knockdown of integrin β4, one of the YKL40 receptors, suppressed YKL40-induced proliferation, migration, and invasion, as well as Erk phosphorylation in some EOC cells. Database analysis showed that high-level expression of YKL40 and integrin β4 correlated with a poor prognosis in patients with serous ovarian carcinoma. Therefore, the YKL40/integrin β4 axis may play a role in ovarian cancer progression.MDPI AG, 2024年10月, International Journal of Molecular Sciences, 25(19) (19), 10598 - 10598, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Pelvic exenteration (PE) is the last resort for achieving a complete cure for pelvic cancer; however, it is burdensome for patients. Minimally invasive surgeries, including robot-assisted surgery, have been widely used to treat malignant tumors and have also recently been used in PE. This study aimed to evaluate the safety and efficacy of robot-assisted PE (RPE) by comparing the outcomes of open PE (OPE) with those of conventional laparoscopic PE (LPE) for treating pelvic tumors. METHODS: Following the ethics committee approval, a multicenter retrospective analysis of patients who underwent pelvic exenteration between January 2012 and October 2022 was conducted. Data on patient demographics, tumor characteristics, and perioperative outcomes were collected. A 1:1 propensity score-matched analysis was performed to minimize group selection bias. RESULTS: In total, 261 patients met the study criteria, of whom 61 underwent RPE, 90 underwent OPE, and 110 underwent LPE. After propensity score matching, 50 pairs were created for RPE and OPE and 59 for RPE and LPE. RPE was associated with significantly less blood loss (RPE vs. OPE: 408 mL vs. 2385 ml, p < 0.001), lower transfusion rate (RPE vs. OPE: 32% vs. 82%, p < 0.001), and lower rate of complications over Clavien-Dindo grade II (RPE vs. OPE: 48% vs. 74%, p = 0.013; RPE vs. LPE: 48% vs. 76%, p = 0.002). CONCLUSION: This multicenter study suggests that RPE reduces blood loss and transfusion compared with OPE and has a lower rate of complications compared with OPE and LPE in patients with locally advanced and recurrent pelvic tumors.2024年08月, Surgical endoscopy, 38(8) (8), 4390 - 4401, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: In human placental development, the trophectoderm (TE) appears in blastocysts on day 5 post-fertilization and develops after implantation into three types of trophoblast lineages: cytotrophoblast (CT), syncytiotrophoblast (ST), and extravillous trophoblast (EVT). CDX2/Cdx2 is expressed in the TE, and Cdx2 expression is upregulated by knockdown of Foxo1 in mouse ESCs. However, the significance of FOXO1 in trophoblast lineage differentiation during the early developmental period remains unclear. In this study, we examined the effect of FOXO1 inhibition on the differentiation of naive human induced pluripotent stem cells (iPSCs) into TE and trophoblast lineages. METHODS: We induced TE differentiation from naive iPSCs in the presence or absence of a FOXO1 inhibitor, and the resulting cells were subjected to trophoblast differentiation procedures without the FOXO1 inhibitor. The cells obtained in these processes were assessed for morphology, gene expression, and hCG secretion using phase-contrast microscopy, reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (RT-qPCR), RNA-seq, immunochromatography, and a chemiluminescent enzyme immunoassay. RESULTS: In the induction of trophoblast differentiation from naive iPSCs, treatment with a FOXO1 inhibitor resulted in the enhanced expression of TE markers, CDX2 and HAND1, but conversely decreased the expression of ST markers, such as ERVW1 (Syncytin-1) and GCM1, and an EVT marker, HLA-G. The proportion of cells positive for an early TE marker TACSTD2 and negative for a late TE marker ENPEP was higher in FOXO1 inhibitor-treated cells than in non-treated cells. The expressions of ERVW1 (Syncytin-1), ERVFRD-1 (Syncytin-2), and other endogenous retrovirus (ERV)-associated genes that have been reported to be expressed in trophoblasts were suppressed in the cells obtained by differentiating the TE cells treated with FOXO1 inhibitor. CONCLUSIONS: Treatment with a FOXO1 inhibitor during TE induction from naive iPSCs promotes early TE differentiation but hinders the progression of differentiation into ST and EVT. The suppression of ERV-associated genes may be involved in this process.2024年06月, Regenerative therapy, 26, 729 - 740, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To examine the association between intrauterine manipulator use and pathological factors and oncologic outcomes in patients with endometrial cancer who had laparoscopic hysterectomy in Japan. METHODS: This was a nationwide retrospective cohort study of the tumor registry of the Japan Society of Obstetrics and Gynecology. Study population was 3846 patients who had laparoscopic hysterectomy for endometrial cancer from January 2015 to December 2017. An automated 1-to-1 propensity score matching with preoperative and intraoperative demographics was performed to assess postoperative pathological factors associated with the intrauterine manipulator. Survival outcomes were assessed by accounting for possible pathological mediators related to intrauterine manipulator use. RESULTS: Most patients had preoperative stage I disease (96.5%) and grade 1-2 endometrioid tumors (81.9%). During the study period, 1607 (41.8%) patients had intrauterine manipulator use and 2239 (58.2%) patients did not. In the matched cohort, the incidences of lymphovascular space invasion in the hysterectomy specimen were 17.8% in the intrauterine manipulator group and 13.3% in the non-manipulator group. Intrauterine manipulator use was associated with a 35% increased odds of lymphovascular space invasion (adjusted odds ratio 1.35, 95% confidence interval (CI) 1.08 to 1.69). The incidences of malignant cells identified in the pelvic peritoneal cytologic sample at hysterectomy were 10.8% for the intrauterine manipulator group and 6.4% for the non-manipulator group. Intrauterine manipulator use was associated with a 77% increased odds of malignant peritoneal cytology (adjusted odds ratio 1.77, 95% Cl 1.29 to 2.31). The 5 year overall survival rates were 94.2% for the intrauterine manipulator group and 96.6% for the non-manipulator group (hazard ratio (HR) 1.64, 95% Cl 1.12 to 2.39). Possible pathological mediators accounted HR was 1.36 (95%Cl 0.93 to 2.00). CONCLUSION: This nationwide analysis of predominantly early stage, low-grade endometrial cancer in Japan suggested that intrauterine manipulator use during laparoscopic hysterectomy for endometrial cancer may be associated with an increased risk of lymphovascular space invasion and malignant peritoneal cytology. Possible mediator effects of intrauterine manipulator use on survival warrant further investigation, especially with a prospective setting.2024年04月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 34(4) (4), 510 - 518, 英語, 国際誌研究論文（学術雑誌）
- Hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) syndrome is one of the most severe complications of hypertensive disorders of pregnancy. HELLP syndrome occurring before 22 gestational weeks (GWs) is extremely rare, and patients prevalently exhibit underlying maternal diseases or fetal abnormalities. Here, we report the case of a pregnant woman who had HELLP syndrome at 20 GWs without any obvious underlying maternal diseases or fetal abnormalities. A 38-year-old pregnant woman was referred to Kobe University Hospital from another hospital at 19 + 5/7 GWs for hypertension, proteinuria, generalized edema, and fetal growth restriction. She was diagnosed with partial HELLP syndrome according to the Mississippi classification at 20 + 2/7 GWs. The patient was managed following the Mississippi protocol, including intravenous dexamethasone, magnesium sulfate, and antihypertensive drugs. She received intensive blood pressure and laboratory data monitoring using an arterial line and additional treatments, including platelet transfusion, intravenous haptoglobin infusion, and human atrial natriuretic peptide. The pregnancy ended in an induced delivery at 20 + 3/7 GWs, and she was discharged without complications 10 days postnatal. We performed laboratory tests for diagnosing underlying diseases but identified no obvious underlying diseases. This report indicates that early and intensive treatment of patients with HELLP syndrome occurring before 22 GWs according to the Mississippi protocol may enable clinicians to complete pregnancy termination without maternal complications and provide useful information to clinical practitioners in perinatal medicine.2024年04月, The Kobe journal of medical sciences, 70(1) (1), E22-E25, 英語, 国内誌研究論文（学術雑誌）
- In association with an update of the Japan Society of Gynecologic Oncology clinical practice guidelines for endometrial cancer in 2023, a systematic review was conducted about the therapeutic benefit of adjuvant therapy on patients with early-stage endometrial carcinoma, who presented positive peritoneal cytology (PPC) without the risk factors for recurrence. The systematic review only included two eligible retrospective studies. Both studies included patients with risk factors for recurrence. A nationwide study in the United States reported that adjuvant chemotherapy was associated with the reduced risk of death among patients with stages I-II endometrial cancer with PPC by multivariate, propensity score-adjusted analysis. Another single-center study in Japan reported no association between adjuvant chemotherapy and relapse-free survival among patients with stage IA endometrial cancer by univariate analysis. This systematic review identified that evidence was limited with conflicting results. Continuous evaluation is warranted to address this clinical question.2024年02月, Japanese journal of clinical oncology, 54(2) (2), 217 - 220, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: This study elucidated the efficacy of Relugolix (REL) on the reduction of uterine volume and clinical symptoms for the treatment of adenomyosis. METHODS: We conducted a retrospective cohort study of patients who received REL (40 mg for about 20 weeks) and who underwent a hysterectomy for adenomyosis or fibroids. We divided patients into two groups: adenomyosis coexisting with fibroids (Group A) and fibroids only (Group B); the groups were determined by a postoperative pathological examination. The primary end points were the percent reduction in uterine volume, adenomyotic lesion, and the largest fibroid volume at week 16. The secondary end points were the rate of amenorrhea, pelvic pain, and anemia at week 12. RESULTS: A total of 56 patients participated in the current study: 20 in Group A and 36 in Group B. Regarding the largest fibroid volume, there was no significant difference between the two groups. Uterine volume after REL treatment was significantly decreased in Group A (43%), as compared to Group B (27%) (p = .00972), In Group A, adenomyotic lesion was decreased by 61%. Irrespective of the group, adenomyosis showed a significant reduction compared to uterine fibroids (p < .001). There was no statistically significant difference in the mitigation of symptoms (amenorrhea, pelvic pain, and anemia) between the two groups. CONCLUSIONS: REL is more effective in reducing adenomyotic lesion than uterine fibroids and in relieving symptoms (amenorrhea, pelvic pain, and anemia). It can be expected that REL will also be used as a preoperative treatment for adenomyosis.2023年12月, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 39(1) (1), 2237121 - 2237121, 英語, 国際誌研究論文（学術雑誌）
- AIMS/INTRODUCTION: To evaluate the efficacy of sensor-augmented pump (SAP) for improving obstetric and neonatal outcomes among pregnant women with type 1 diabetes mellitus by comparing it with continuous subcutaneous insulin infusion plus self-monitoring of blood glucose (continuous subcutaneous insulin infusion [CSII]/SMBG). MATERIALS AND METHODS: This retrospective cohort study included 40 cases of pregnancy complicated by type 1 diabetes mellitus treated with SAP (SAP group), and 29 cases of pregnancy complicated by type 1 diabetes mellitus treated with CSII/SMBG (CSII/SMBG group). The obstetric and neonatal outcomes were compared between the two groups. RESULTS: The median of the glycoalbumin levels in the first (18.8% vs 20.9%; P < 0.05) and second (15.4% vs 18.0%; P < 0.05) trimesters, the hemoglobin A1c levels in the peripartum period (6.1% vs 6.5%; P < 0.05) and the standard deviation score of birthweights (0.36 vs 1.52; P < 0.05) were significantly lower in the SAP group than in the CSII/SMBG group. The incidence rate of large for gestational age newborns was significantly lower in the SAP group than in the CSII/SMBG group (27.5% vs 65.5%; P < 0.05). No significant differences in the incidence rates of hypertensive disorders of pregnancy, small for gestational age, respiratory distress syndrome, neonatal hypoglycemia, hypervolemia and hyperbilirubinemia were observed between the groups. CONCLUSION: The present study showed that SAP therapy is more effective in preventing large for gestational age newborns in pregnant women with type 1 diabetes mellitus than CSII/SMBG.2023年12月, Journal of diabetes investigation, 14(12) (12), 1383 - 1390, 英語, 国内誌研究論文（学術雑誌）
- INTRODUCTION AND IMPORTANCE: A case of Low-grade endometrial stromal sarcoma (LG-ESS) invading the great vessels is rare. CASE PRESENTATION: A 34-year-old female who had no past history presented to a previous hospital with abdominal distension. Magnetic resonance imaging revealed a 15 cm pelvic mass beside the uterus, and only the pelvic mass was removed at the surgery. The tumor was judged to be a LG-ESS. The patient chose to be observed to preserve her fertility, and no adjuvant treatment was undertaken. Two years later, she was referred to our hospital due to recurrence of the pelvic mass. Enhanced computed tomography revealed a large tumor in the vena cava which extended from the left internal iliac vein and which originated from the pelvic tumor. An operation was performed by a multidisciplinary team. Complete resection of the tumor was achieved with a radical hysterectomy, bilateral salpingo-oophorectomy, removal of recurrent pelvic masses and the intravascular tumor. We diagnosed a recurrence of LG-ESS. She received a postoperative adjuvant therapy of LG-ESS. CLINICAL DISCUSSION: Patients with fertility-sparing treatment had higher recurrence rates. In cases of tumor intravenous extension, we should make every effort to extract the tumor to avoid sudden death. CONCLUSION: This case highlights the importance of a multidisciplinary approach in treating this rare tumor with intravascular extension. In particular, patients with LG-ESS who receive fertility-sparing surgery should undertake postoperative chemotherapy or radiotherapy in order to reduce the risk of recurrence, as was in this case.2023年10月, International journal of surgery case reports, 111, 108857 - 108857, 英語, 国際誌研究論文（学術雑誌）
- AIM: Minimally invasive surgery (MIS) has been introduced as an alternative to more radical surgical procedures. The Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy conducted a cross-sectional questionnaire survey to ascertain the status of MIS for endometrial cancer. METHODS: The survey was conducted between May 10 and June 30, 2022. The questionnaire included information on personal attributes, academic affiliations, qualifications, hysterectomies, and intraoperative procedures performed. RESULTS: The total number of questionnaire respondents was 436 (9.2% of the membership). The hysterectomy methods and percentage performed were as follows: simple total hysterectomy (equivalent to benign surgery), 3%; simple total hysterectomy with care to avoid shaving the cervix, 31%; extended total hysterectomy, 48%; and modified radical hysterectomy, 15%. An analysis of hysterectomies performed using MIS for endometrial cancer by qualified gynecologists of endoscopy or board-certified gynecologic oncologists showed a tendency not to choose simple total hysterectomy compared to the gynecologists who did not hold certification (p = 0.019, p = 0.045, and p = 0.010, respectively). Additionally, 67% of respondents did not use uterine manipulators, and 59% of the respondents did not perform lymph node dissection following the guidelines for treating endometrial cancer in Japan. CONCLUSION: This study provided the current status of MIS for endometrial cancer in Japan. The hysterectomy method, use of uterine manipulators, and criteria for omitting lymph node dissection were generally in agreement with the guidelines. Currently, an extra-fascial simple hysterectomy, including at least not shaving the cervix, was a major method for early invasive endometrial cancer using MIS.2023年09月, The journal of obstetrics and gynaecology research, 49(9) (9), 2370 - 2378, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本癌学会, 2023年09月, 日本癌学会総会記事, 82回, 1401 - 1401, 英語腫瘍関連マクロファージとの相互作用による卵巣癌の進展機構の解析(Analysis of interactions between carcinoma cells and tumor-associated macrophages in the progression of ovarian cancer)
- (一社)日本癌学会, 2023年09月, 日本癌学会総会記事, 82回, 1401 - 1401, 英語腫瘍関連マクロファージとの相互作用による卵巣癌の進展機構の解析(Analysis of interactions between carcinoma cells and tumor-associated macrophages in the progression of ovarian cancer)
- Ovarian cancer (OC) is a refractory cancer that shows recurrence due to the acquisition of resistance to anticancer drugs, including cisplatin. However, the molecular mechanism underlying the acquisition of cisplatin resistance by cancer cells remains largely unknown. In the present study, two sets of ovarian endometrioid carcinoma cell lines were used: The parental A2780 cell line, the OVK18 cell line, and their derived cisplatin‑resistant cells. It was found that cisplatin could induce ferroptosis in these parental cells by enhancing mitochondrial membrane potential and lipid peroxidation as assessed by flow cytometric analysis, and that expression of Ferredoxin1 (Fdx1), an iron‑sulfur protein localized to the mitochondria, could be upregulated in cisplatin‑resistant cells in the absence of cisplatin. Intriguingly, it was shown that the siRNA‑mediated depletion of Fdx1 in cisplatin‑resistant cells resulted in enhanced ferroptosis by increasing the mitochondrial membrane potential and lipid peroxidation induced by cisplatin. By examining Fdx1 expression with immunohistochemical analysis in clinical specimens from patients with OC, higher expression of Fdx1 was detected in cisplatin‑resistant specimens than in cisplatin‑sensitive specimens. Collectively, these results indicated that Fdx1 may be a novel and suitable diagnostic/prognostic marker and therapeutic molecular target for the treatment of cisplatin‑resistant OC.2023年06月, Oncology reports, 49(6) (6), 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Owing to the potential benefits of minimally invasive hysterectomy for endometrial cancer, the practice pattern has recently shifted in Japan. This study examined the trends in minimally invasive surgery (MIS) in patients with endometrial cancer in Japan. METHODS: This retrospective observational study examined the Japan Society of Obstetrics and Gynecology Tumor Registry database between 2015-2019. This study examined the time-specific proportion change and predictors of MIS use in initial endometrial cancer treatment in Japan, and compared it with the use of abdominal surgery. Additionally, the association between hospital surgical treatment volume and MIS use was examined. RESULTS: A total of 14,059 patients (26.5%) underwent minimally invasive hysterectomy, and 39,070 patients (73.5%) underwent abdominal hysterectomy in the study period. Patients who underwent MIS were more likely to be treated at high-volume centers, younger, central, or western Japan residents, registered in recent years, and had a tumor with stage I disease, type 1 histology, and less myometrial invasion (all adjusted p<0.05). The proportion of MIS treatments increased from 19.1% in 2015 to 34.3% in 2019 (p<0.001). On multivariable analysis, treatment at high-volume centers was a contributing factor for MIS (adjusted odds ratio=3.85; 95% confidence interval=3.44-4.30). MIS at high-volume centers increased significantly from 24.8% to 41.0% (p<0.001) during the study period, whereas MIS at low-volume centers remained at median 8.8%. CONCLUSION: MIS has increased significantly in recent years, accounting for nearly 34% of surgical management of endometrial cancer in Japan. High-volume treatment centers take the lead in performing MIS.2023年05月, Journal of gynecologic oncology, 34(3) (3), e56, 英語, 国際誌研究論文（学術雑誌）
- Intramural pregnancy is a rare form of ectopic pregnancy. It is defined by a gestation within the uterine wall, completely surrounded by myometrium and separated from the uterine cavity and the fallopian tube. We report a rare case of intramural ectopic pregnancy. If a patient has a history of intrauterine surgery or myomectomy, the possibility of intramural pregnancy, although rare, should not be ruled out.2023年01月, Asian journal of endoscopic surgery, 16(3) (3), 510 - 513, 英語, 国内誌研究論文（学術雑誌）
- Human papillomavirus (HPV) vaccine has been used to prevent chronic HPV infection, which accounts for cervical cancer. Japanese Ministry of Health, Labor and Welfare (MHLW) conducted an HPV vaccination campaign in 2010 and the Obstetrical Gynecological Society of Osaka initiated a multicenter, prospective cohort study in Osaka, Japan - OCEAN (Osaka Clinical resEArch of HPV vacciNe) study - to investigate the oncogenic HPV prevalence and the long-term protection rate of HPV vaccine. A total of 2814 participants were enrolled on their visit for HPV vaccination between 12 and 18 years old. Among them, 102 participants received HPV/Pap co-test as primary cancer screening at the age of 20-21. We compared the prevalence in two groups (the vaccinated and the unvaccinated group). HPV infection ratio was significantly lower in the vaccinated group compared to the unvaccinated (12.9% vs. 19.7%; p = .04). In particular, HPV 16 and 18 were not detected in the vaccinated group, while 4.9% of participants in the unvaccinated group were infected (p = .001), suggesting that vaccination provided effective protection against high-risk types of HPV. The cross-protection effect of HPV vaccines was also observed against HPV 31, 45, and 52. Although HPV vaccines were not contributed to the reduction of cervical intraepithelial neoplasia 1 (CIN) (p = .28), CIN2 or worse was not observed in vaccinated group. Our research showed that at the age of 20-21, HPV vaccine inhibited the infection of high-risk HPV and had impacted on the development to CIN2 or worse in Japan.2022年12月, Human vaccines & immunotherapeutics, 18(1) (1), 1951098 - 1951098, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Ovarian cancer (OC) is the fifth most common cancer of female cancer death and leading cause of lethal gynecological cancers. High-grade serous ovarian carcinoma (HGSOC) is an aggressive malignancy that is rapidly fatal. Many cases of OC show amplification of the 8q24 chromosomal region, which contains the well-known oncogene MYC. Although MYC amplification is more frequently observed in OCs than in other tumor types, due to the large size of the 8q24 amplicon, the functions of the vast majority of the genes it contains are still unknown. The TIGD5 gene is located at 8q24.3 and encodes a nuclear protein with a DNA-binding motif, but its precise role is obscure. We show here that TIGD5 often co-amplifies with MYC in OCs, and that OC patients with high TIGD5 mRNA expression have a poor prognosis. However, we also found that TIGD5 overexpression in ovarian cancer cell lines unexpectedly suppressed their growth, adhesion, and invasion in vitro, and also reduced tumor growth in xenografted nude mice in vivo. Thus, our work suggests that TIGD5 may in fact operate as a tumor suppressor in OCs rather than as an oncogene.2022年11月, Genes to cells : devoted to molecular & cellular mechanisms, 27(11) (11), 633 - 642, 英語, 国際誌研究論文（学術雑誌）
- AIM: To evaluate the impact on urodynamic results between the laparoscopic nerve-sparing radical hysterectomy (LRH) following a step-by-step procedure and abdominal nerve-sparing radical hysterectomy (ARH) for patients with uterine cervical cancer. METHODS: This retrospective study enrolled 76 patients with cervical cancer: 35 in the LRH group and 41 in the ARH group. We analyzed their postoperative bladder function in a urodynamics study and examined the volume of resected pelvic nerves contained in parametrial sections using S-100 antibody staining. RESULTS: Estimated blood loss and hospital stay after operation for the LRH group were significantly better than those in the ARH group (p < 0.0001). As well, the number of harvested lymph nodes was significantly higher in the LRH group (p = 0.044). There was no difference in perioperative complications between the two groups in this study. The 5-year disease-free survival rates and overall survival rates were 91.2% and 94.0% in the LRH group and 87.8% and 95.1% in the ARH group, both respectively. Although the median residual urine volume were no statistical differences between the LRH group and the ARH group, the recovery of postoperative bladder function (uroflowmetry) in the LRH group rapidly reached presurgery levels at 1 month, and the LRH group had a smaller number of s-100 antibody stained nerves contained the parametrial sections. CONCLUSION: We demonstrated that LRH following a step-by-step procedure could achieve a higher level of prevention of damage to the bladder branch of the pelvic splanchnic nerve plexus and thus restore bladder function more rapidly.2022年11月, The journal of obstetrics and gynaecology research, 48(11) (11), 2863 - 2871, 英語, 国際誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2022年08月, 産婦人科の進歩, 74(3) (3), 466 - 468, 日本語
- 日本女性栄養・代謝学会, 2022年05月, 日本女性栄養・代謝学会誌, 27(2) (2), 131 - 131, 日本語
- Springer Science and Business Media LLC, 2022年03月, International Journal of Clinical Oncology, 27(6) (6), 1084 - 1092, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- PURPOSE: This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer. MATERIALS AND METHODS: Eligible patients had platinum-resistant epithelial ovarian cancer, received ≤ 1 regimen after diagnosis of resistance, and had an Eastern Cooperative Oncology Group performance score of ≤ 1. Patients were randomly assigned 1:1 to nivolumab (240 mg once every 2 weeks [as one cycle]) or chemotherapy (GEM 1000 mg/m2 for 30 minutes [once on days 1, 8, and 15] followed by a week's rest [as one cycle], or PLD 50 mg/m2 once every 4 weeks [as one cycle]). The primary outcome was overall survival (OS). Secondary outcomes included progression-free survival (PFS), overall response rate, duration of response, and safety. RESULTS: Patients (n = 316) were randomly assigned to nivolumab (n = 157) or GEM or PLD (n = 159) between October 2015 and December 2017. Median OS was 10.1 (95% CI, 8.3 to 14.1) and 12.1 (95% CI, 9.3 to 15.3) months with nivolumab and GEM or PLD, respectively (hazard ratio, 1.0; 95% CI, 0.8 to 1.3; P = .808). Median PFS was 2.0 (95% CI, 1.9 to 2.2) and 3.8 (95% CI, 3.6 to 4.2) months with nivolumab and GEM or PLD, respectively (hazard ratio, 1.5; 95% CI, 1.2 to 1.9; P = .002). There was no statistical difference in overall response rate between groups (7.6% v 13.2%; odds ratio, 0.6; 95% CI, 0.2 to 1.3; P = .191). Median duration of response was numerically longer with nivolumab than GEM or PLD (18.7 v 7.4 months). Fewer treatment-related adverse events were observed with nivolumab versus GEM or PLD (61.5% v 98.1%), with no additional or new safety risks. CONCLUSION: Although well-tolerated, nivolumab did not improve OS and showed worse PFS compared with GEM or PLD in patients with platinum-resistant ovarian cancer.2021年11月, Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 39(33) (33), 3671 - 3681, 英語, 国際誌研究論文（学術雑誌）
- Radiotherapy (RT) is used to manage cervical cancer, and pelvic insufficiency fracture (PIF) is known as a late complication of RT. The present study identified risk factors for PIF after radiotherapy for cervical cancer, and investigated its incidence rate. It also considered the usefulness of positron emission tomography/magnetic resonance imaging (PET/MRI) in PIF diagnosis. A total of 149 patients with cervical cancer who received definitive or adjuvant RT with/without concurrent chemotherapy between January 2013 and December 2018 were investigated in the present study and followed up for more than one month after RT at Kobe University Hospital. The median follow-up period was 32 months (range, 1-87 months), and the median age of all patients was 66 years (age range, 34-90 years). Computed tomography (CT), MRI, PET/CT or PET/MRI were used for image examination. Among the 149 patients, 31 (20.8%) developed PIF. The median age of these patients was 69 years (age range, 44-87 years). Univariate analysis using the log-rank test demonstrated that age (≥60 years) was significantly associated with PIF. The median maximum standardized uptake value of PIF sites on PET/CT was 4.32 (range, 3.04-4.81), and that on PET/MRI was 3.97 (range, 1.21-5.96) (P=0.162). Notably, the detection time of PIF by PET/MRI was significantly earlier compared with PET/CT (P<0.05). The incidence of PIF after RT for cervical cancer was 20.8%, and age was significantly associated with risk factors for such fractures. Taken together, these results suggest that PET/MRI, which offers the advantage of decreased radiation exposure to the patient, is useful for diagnosing PIF and can detect it earlier than PET/CT imaging.2021年11月, Oncology letters, 22(5) (5), 776 - 776, 英語, 国際誌研究論文（学術雑誌）
- Placental mesenchymal dysplasia (PMD) is a rare placental abnormality that is closely related to severe pregnancy complications. A 27-year-old woman with fetal growth restriction and placenta previa was referred to a university hospital at 22 gestational weeks (GW). She was suspected of having a twin pregnancy with a complete or partial hydatidiform mole and coexisting normal live fetus, because two separate placentas, an enlarged one with multiple cystic lesions and a normal one, were shown on ultrasound examinations. At 27 GW, she experienced a sudden intrauterine fetal death (IUFD) after bleeding due to placenta previa, despite confirmation of fetal well-being at 2 h before bleeding. After delivery, histopathological examination confirmed the diagnosis of PMD. This is the first documented case of a woman with PMD and placenta previa who had a sudden IUFD after bleeding. Patients with both PMD and placenta previa should be considered at extremely high risk for IUFD.2021年11月, The journal of obstetrics and gynaecology research, 47(11) (11), 4087 - 4092, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- A 40-year-old primigravida woman with a monochorionic-triamniotic (MT) triplet pregnancy was hospitalized due to threatened abortion at 16 gestational weeks. Polyhydramnios in two fetuses and oligohydramnios in the third supported a diagnosis of feto-fetal transfusion syndrome (FFTS) at 23 weeks and 3 days of gestation. Severe dyspnea and liver dysfunction required intensive care unit admission and mechanical ventilation support, and abdominal compartment syndrome (ACS) caused by polyhydramnios was clinically diagnosed. When her general condition was not improved regardless of intensive care, the patient delivered the three fetuses by cesarean section at 23 weeks and 5 days gestation. Abdominal decompression was achieved with delivery, and the patient was discharged 13 days after operation without morbidity. This is the first case report of ACS caused by FFTS in a MT triplet pregnancy resulting in extremely preterm birth.2021年09月, The journal of obstetrics and gynaecology research, 47(9) (9), 3370 - 3373, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- INTRODUCTION: Placenta accreta spectrum (PAS) is a life-threating obstetric complication, and prenatal prediction of PAS can decrease maternal morbidity and mortality. The aim of this prospective cohort study was to determine the clinical factors associated with PAS. METHODS: Pregnant women who delivered at a university hospital were enrolled. Clinical data were collected from medical records, and logistic regression analyses were performed to determine which clinical factors were associated with PAS. RESULTS: Eighty-seven (2.1%) of the 4146 pregnant women experienced PAS. Multivariable analyses revealed that a prior history of cesarean section (CS) (OR 3.3; 95% CI 1.9-5.7; p < 0.01), dilation and curettage (D&C) (OR 2.8; 95% CI 1.7-4.6; p < 0.01), hysteroscopic surgery (OR 5.7; 95% CI 2.3-14.4; p < 0.01), uterine artery embolization (UAE) (OR 44.1; 95% CI 13.8-141.0; p < 0.01), current pregnancy via assisted reproductive technology (ART) (OR 4.1; 95% CI 2.4-7.1; p < 0.01), and the presence of placenta previa in the current pregnancy (OR 13.1; 95% CI 7.9-21.8; p < 0.01) were independently associated with the occurrence of PAS. CONCLUSION: Pregnant women who have a prior history of CS, D&C, hysteroscopic surgery, UAE, current pregnancy via ART, and the presence of placenta previa in the current pregnancy are high risk for PAS.2021年09月, Placenta, 112, 180 - 184, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: The purpose of our study was to conduct a detailed survey of radical hysterectomy in Japanese patients with early-stage cervical cancer, and to compare oncologic outcomes between open and minimally invasive radical hysterectomy. METHODS: In Japan during 2015, the medical records of 929 patients with FIGO stage IB1 and IIA disease treated with radical hysterectomy were retrospectively reviewed. We assessed patients' characteristics, disease-free survival (DFS), overall survival (OS) and prognostic factors for survival. RESULTS: The median patient age was 44 (20-80) years. Most patients (94.4%) had stage IB1 disease. Of the patients who underwent radical hysterectomy, 91.2% underwent open surgery and 8.8% underwent minimally invasive surgery (MIS). The median follow-up period was 40.8 months (range, 0.49-51.1 months). The rate of DFS and OS at 4 years in all patients was 88.3% and 96.4%, respectively. Multivariate analysis identified age (≥ 47), adenocarcinoma histology, tumor size (≥ 2 cm), parametrial invasion, positive lymph node metastasis and institutional accreditation as independent predictors of recurrence, and adenocarcinoma, other cell types, and positive lymph node metastasis as independent predictors of death. Oncologic outcomes in all patients were similar between open and MIS, including DFS and OS. CONCLUSION: The survival rate of the Japanese patients underwent radical hysterectomy for early-stage cervical cancer was favorable. No significant differences were observed for DFS and OS between open and MIS performed by a limited number of surgeons at a limited number of facilities in Japan. Further investigations are required to identify the appropriate patients might benefit from MIS.2021年08月, International journal of clinical oncology, 26(12) (12), 2318 - 2330, 英語, 国内誌研究論文（学術雑誌）
- AIM: To evaluate whether embryo selection using the early embryo viability assessment (EEVA) score increases the ongoing pregnancy rate of in vitro fertilization and intracytoplasmic sperm injection patients. METHODS: One hundred eighty-one patients whose serum anti mullerian hormone (AMH) level was greater than 0.5 ng/μL were enrolled in the study. All patients received oocyte retrieval repeatedly from June 2017 to January 2019. Transferred embryos were selected using the EEVA score and Veeck's criteria. We investigated the blastocyst rate according to the EEVA score and Veeck's criteria and also evaluated the clinical outcome following embryo transfer of the blastocysts. RESULTS: Blastocyst development rate (48.7%) and high-quality blastocyst (42.4%) of Veeck 1 was statistically higher than others. The blastocyst rate (71.4%) and high-quality blastocyst rate (60.0%) for EEVA 1 was the highest, and a correlation between the EEVA score and the blastocyst rate was also identified in cases younger than 40 years. Blastocyst rate of EEVA 1 + 2 (69.8% 208/298) was statistically higher than that of Veeck 1 + 2 (40.1% 317/791) (p < 0.05) and high-quality blastocyst rate of EEVA 1 + 2 (50.0% 104/208) was also higher than that of Veeck 1 + 2 (36.6% 117/320) (p < 0.05). However, there was a significant correlation between EEVA and the pregnancy rate and pregnancy rate of EEVA 1 + 2 showed no statistical difference compared with Veeck 1 + 2. CONCLUSIONS: Although it remains to be answered whether a computer can substitute Veeck's classification, the EEVA score could be a viable alternative to predict the blastocyst rate and to select those high-potential embryos that improve the pregnancy rate.2021年07月, The journal of obstetrics and gynaecology research, 47(7) (7), 2387 - 2393, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Serous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is an intraepithelial lesion but has been reported to cause extrauterine metastases. We report a case of SEIC with serous ovarian carcinoma and lymph node metastasis. CASE PRESENTATION: A 57-year-old post-menopausal woman (gravida 3, para 2, SA1) was referred to our hospital with lower abdominal pain. An ultrasound and MRI showed that the ovary had swollen to 8 cm in size and had a solid lesion. The uterus was normal. The patient underwent exploratory laparoscopy on the suspicion of torsion of the ovarian tumor. Intraoperative findings showed a right ovarian tumor, but no ovarian tumor torsion was observed. A small amount of bloody ascites was found in the Douglas fossa, and bleeding was observed from the tumor itself. A right salpingo-oophorectomy was then performed. Histopathological results revealed a high-grade serous carcinoma. Forty days after the first surgery, we performed a staging laparotomy: a total abdominal hysterectomy, left salpingo-oophorectomy, systematic pelvic and paraaortic lymphadenectomy, and a partial omentectomy. A complete cytoreduction was achieved. In the pathological examination, the invasion of the serous carcinoma was observed in the left ovarian ligament, and lymph node metastasis was found in the paraaortic lymph nodes. Atypical columnar cells formed irregular papillary lesions which had proliferated in the endometrium, and this was diagnosed as SEIC. The final diagnosis was serous ovarian cancer, FIGO stage IIIA1(ii), pT2bN1M0, with SEIC. CONCLUSION: We report a case of SEIC with synchronous serous carcinoma of the adnexa uteri. Both were serous carcinomas and, thus, it was difficult to identify the primary lesion. The distinction between metastatic cancer and two independent primary tumors is important for an accurate diagnosis and tumor staging. Histological diagnostic criteria remain controversial, and further development of a method for differentiating between both diseases is required.2021年06月, Journal of ovarian research, 14(1) (1), 87 - 87, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, 日本語非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, 日本語胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する
- BACKGROUND: Sentinel lymph node (SN) biopsy is essential for evaluating survival and minimal treatment-related morbidity associated with cervical, endometrial, and vulvar cancer in Japan. As such, our aim in this study was to evaluate the current practice pattern of using SN biopsy for cervical, endometrial, and vulvar cancer in Japan. METHODS: We deployed a 47-question survey on the use of SN biopsy for gynecological cancers to 216 gynecological oncology training facilities. The survey included information on the use of SN biopsy for uterine (cervical and endometrial) and vulvar cancers; details on the type, timing, and concentration of tracers used; surgical approach used for SN biopsy; method of biopsy and pathological examination; and facilities' experience with clinical research on SN biopsy. RESULTS: The response rate was 84% (181/216), with 40 facilities (22%) having experience in SN biopsy for gynecological cancers, 34 (85%) for uterine cancers, and 15 (37%) for vulvar cancers. Radioisotope, indocyanine green (ICG), and blue dyes were available for the detection of uterine cancers in 21 (52%), 25 (62%), and 19 (48%) facilities and for vulvar cancers in 9 (22%), 3 (7%), and 11 (27%) facilities, respectively. Thirty-four facilities (85%) used intraoperative frozen section procedure for diagnosis when possible, with 24 (71%) of these facilities using 2-mm specimen cuts. Diagnosis included pathological examination (85%), immunostaining (57%), and one-step nucleic acid amplification (5%). CONCLUSION: Increasing research evidence, providing insurance coverage for radioisotope tracers, and increasing the availability of training are expected to increase the use of SN biopsy in Japan.2021年05月, International journal of clinical oncology, 26(5) (5), 971 - 979, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2021年05月, 産婦人科の進歩, 73(2) (2), 137 - 137, 日本語
- 「産婦人科の進歩」編集室, 2021年05月, 産婦人科の進歩, 73(2) (2), 152 - 152, 日本語
- BACKGROUND: The development of perforations or fistulas in the Gastrointestinal (GI) tract or genitourinary (GU) system is a serious adverse effect of bevacizumab. The aim of this study was to investigate the incidences of these GI/GU events as well as their association with previous radiotherapy (RT) in Japanese women with cervical cancer. METHODS: We conducted a written questionnaire survey among 14 gynecological institutions belonging to the Oncology Research Committee of the Obstetrical and Gynecological Society of Kinki District, Japan. The severity of GI/GU events was classified according to the National Cancer Institute's Common Terminology Criteria for Adverse Events version 5.0. All data were extracted from survey responses and maintained in an Excel spreadsheet and summarized using descriptive statistics. RESULTS: The information of 224 Japanese women with cervical cancer (152 recurrent and 72 advanced) who were treated with bevacizumab-containing chemotherapy was collected from 14 institutions. Of these, 65% had been previously treated with RT. GI/GU events of any grade developed in 25 (11.2%) patients, leading directly to death in 3 (1.3%) patients. When compared, the incidence of GI/GU events was higher in recurrent disease patients than in advanced disease patients (13.8% vs 5.6%, p = 0.0728). When examined according to the history of RT, the incidence of GI/GU events was greater in patients with a history of RT than in those without (14.5% vs 5.1%, p = 0.044). CONCLUSION: More than 10% of patients experience GI/GU events during or after receiving bevacizumab-containing chemotherapies. Prior RT is a risk factor for bevacizumab-associated GI/GU events.Springer Science and Business Media LLC, 2021年03月, International journal of clinical oncology, 26(3) (3), 598 - 605, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (公社)日本婦人科腫瘍学会, 2021年01月, 日本婦人科腫瘍学会雑誌, 39(1) (1), 115 - 115, 日本語先進医療下子宮体癌に対する腹腔鏡下傍大動脈リンパ節郭清術登録結果の検討
- (公社)日本婦人科腫瘍学会, 2021年01月, 日本婦人科腫瘍学会雑誌, 39(1) (1), 294 - 294, 日本語腹腔鏡下手術及び開腹手術との比較によるロボット支援下準広汎子宮全摘術導入の安全性に関する検討
- (公社)日本婦人科腫瘍学会, 2021年01月, 日本婦人科腫瘍学会雑誌, 39(1) (1), 311 - 311, 日本語Saturated salt solution固定法Cadaverを用いた腹腔鏡下婦人科悪性腫瘍手術トレーニング
- (公社)日本婦人科腫瘍学会, 2021年01月, 日本婦人科腫瘍学会雑誌, 39(1) (1), 318 - 318, 日本語後期高齢者における抗がん剤治療の安全性についての検討
- Cervical cancer is the fourth-most prevalent malignancy in women. For advanced cervical cancer, radiotherapy is a major treatment. Micro RNAs (miRNAs) are small, noncoding RNAs that negatively regulate the target gene expression posttranscriptionally. miR-22 is frequently downregulated in various cancers including cervical cancer, and is associated with a poor prognosis in cervical cancer. Exosomes are small endosomally secreted vesicles that carry components such as proteins, messenger RNA (mRNA), DNA and miRNA. We investigated whether or not exosomes can efficiently deliver miR-22 to recipient cervical cancer cells and affect the gene expression in the cells, as well as assessed the role of exosomal miR-22 in radiosensitivity. Exosomes containing high levels of miR-22 were extracted by ultracentrifugation and then characterized by Western blotting, a nanoparticle tracking analysis and electron microscopy. The high presence of miR-22 in the exosome was confirmed by real-time polymerase chain reaction. After the administration of the collected exosomal miR-22 to SKG-II and C4-I cervical cancer cells, the level of miR-22 in the cells was significantly increased, indicating the absorption of the exosomal miR-22. When miR-22 encapsulated in exosomes was administered to the SKG-II cells, the level of c-Myc binding protein (MYCBP) and human telomerase reverse transcriptase (hTERT) was significantly decreased in correlation with increased radiosensitivity determined by a clonogenic assay. Taken together, these results suggest that the administration of exosomal miR-22 may be a novel drug delivery system for cervical cancer radiotherapy.2020年12月, Cancer biology & therapy, 21(12) (12), 1128 - 1135, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2020年08月, 産婦人科の進歩, 72(3) (3), 211 - 215, 日本語
- INTRODUCTION: In Japan, two groups of women, HPV vaccinated and unvaccinated, are approaching age 20, when they should begin cervical cancer screening. To improve Japan's current poor cervical cancer screening rate, we need to know how these women are thinking about screening. METHODS: We conducted an internet survey of 20-y-old women, exploring their understanding of HPV and cervical cancer screening. We then gave them leaflets with basic information about HPV and cervical cancer, stressing the importance of early detection by screening. We analyzed the leaflet's effects on their attitudes based on their vaccination status. RESULTS: Our study of 618 women found a significantly higher intention for engagement for cervical cancer screening in women HPV-vaccinated as teenagers (29% versus 17%). They were also more aware that: (1) HPV is transmitted by sexual intercourse (49.1% versus 39.2%); (2) the HPV vaccine prevents cervical cancer (49.0% to 34.0%); and (3) the appropriate cervical cancer screening interval is every 2 y (63.3% versus 56.2%). Women in both groups responded well to the leaflet, with significant improvements in intention to receive screening. However, 65%-67% were not swayed. DISCUSSION: HPV-vaccinated women were more knowledgeable about cervical cancer and had a greater intention to receive screening. Our educational leaflet was moderately effective in both groups for increasing intentions to screen, but the majority in both groups were still resistant to screening. CONCLUSION: Japan needs to develop more effective educational programs and tools to vigorously impart the importance of cervical cancer screening.2020年07月, Human vaccines & immunotherapeutics, 17(2) (2), 1 - 9, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: MicroRNAs (miRNAs) have been implicated to play a vital role in development, differentiation, cell proliferation and apoptosis. However, which miRNAs are actually associated with endometriosis-associated ovarian cancer remains controversial. METHODS: Serum and ascites samples were obtained from all patients. Serum samples from 5 cases of ovarian endometrioma and endometriosis-associated ovarian cancer each were submitted for comprehensive miRNA microarray profiling. We investigated the differential expression of miRNAs between the two groups to confirm the pivotal role of miRNAs. Quantitative reverse transcription-polymerase chain reaction validation of five selected miRNAs [miR-92a-3p, miR-486-5p, miR-4484, miR-6821-5p, and miR-7108-5p] was performed, and miR-486-5p expression analysis was followed by proliferation and wound healing assays, depending on the expression of miR-486-5p. RESULT: miR-486-5p expression in serum and ascites samples from endometriosis-associated ovarian cancer patients was significantly higher than that from ovarian endometrioma patients. Moreover, the miR-486-5p level in serum and ascites samples was significantly correlated with the severity of the endometriosis. The upregulation of miR-486-5p in immortalized ovarian endometrioma cells significantly increased proliferation and migration. In contrast, the downregulation of miR-486-5p in these cells significantly decreased proliferation and migration. CONCLUSION: miR-486-5p might function as an oncogenic miRNA in endometriosis-associated ovarian cancer and could be a noninvasive biomarker to prospect the severity of ovarian endometrioma.2020年05月, Journal of ovarian research, 13(1) (1), 51 - 51, 英語, 国際誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2020年05月, 産婦人科の進歩, 72(2) (2), 169 - 169, 日本語Sex cord tumor with annular tubulesの1例
- 「産婦人科の進歩」編集室, 2020年05月, 産婦人科の進歩, 72(2) (2), 186 - 186, 日本語子宮筋腫の術前治療におけるGnRHアンタゴニストの有用性についての検討
- (公社)日本婦人科腫瘍学会, 2020年04月, 日本婦人科腫瘍学会雑誌, 38(2) (2), 193 - 199, 日本語
- CD24, which is upregulated in several human malignancies, is related to Epithelial-mesenchymal-transition (EMT) and has characteristics of cancer stem-like cells, especially in cisplatin-resistant ovarian carcinoma cells. Drug delivery systems represent a promising therapeutic approach for diseases with treatment resistance, and the present study investigated a novel CD24-targeted drug delivery system for advanced ovarian carcinoma. We produced liposomal cisplatin with a red fluorescent substance - cyanine 5.5 (GL-CDDP-Cy5.5). In order to target CD24-positive cells, an anti-CD24 monoclonal antibody was modified to the above drug (CD24-GL-CDDP-Cy5.5). Specific uptake of CD24-GL-CDDP-Cy5.5 was confirmed using a therapeutically resistant ovarian cancer cell line, Caov-3 cells. Antitumor effects of CD24-GL-CDDP-Cy5.5 were then evaluated in Caov-3 ×enograft mice. CD24-GL-CDDP-Cy5.5 showed more specific uptake by flow cytometry than GL-CDDP-Cy5.5. In xenograft mice, GL-CDDP-Cy5.5 and CD24-GL-CDDP-Cy5.5 treatment had significantly higher platinum concentration in disseminated tumor cells than cisplatin (P<0.05). Moreover, CD24-GL-CDDP-Cy5.5 suppressed tumor growth and prolonged survival time compared with other treatments. Median survival times of the control, cisplatin, GL-CDDP-Cy5.5 and CD24-GL-CDDP-Cy5.5 groups were 37, 36, 46 and 54 days after inoculation, respectively. Immunohistochemical analysis showed that CD24-GL-CDDP-Cy5.5 treatment, compared with GL-CDDP-Cy5.5, decreased the number of CD24-positive cells and suppressed the EMT phenomenon significantly (P<0.05). The present study demonstrated that CD24-GL-CDDP-Cy5.5, compared with other treatments, improved therapeutic efficacy. The present results suggested the potential for targeting anticancer therapeutics for CD24-positive cells to prevent disease progression.2020年03月, Oncology letters, 19(3) (3), 1872 - 1880, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本産科婦人科学会, 2020年03月, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 401, 日本語卵巣癌において浸潤能,遊走能を促進する新規遺伝子の検索
- (公社)日本産科婦人科学会, 2020年03月, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 490, 日本語当院における子宮頸癌に対するベバシズマブの使用経験
- (公社)日本産科婦人科学会, 2020年03月, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 535, 日本語子宮頸癌に対する放射線治療後の不全骨折発症のリスク因子についての後方視的検討
- (公社)日本産科婦人科学会, 2020年03月, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 627, 日本語当院におけるロボット支援下手術の導入と腹腔鏡手術との比較検討
- (公社)日本産科婦人科学会, 2020年03月, 日本産科婦人科学会雑誌, 72(臨増) (臨増), S - 643, 日本語BevacizumabとOlaparibの併用療法によって再発卵巣癌治療は変わったか?
- MicroRNAs (miRs) influence the expression of their target genes post-transcriptionally and serve an important role in multiple cellular processes. The downregulation of miR-22 is associated with a poor prognosis in cervical cancer. However, the mechanisms underlying miR-22-mediated gene regulation and its function are yet to be elucidated. In the present study, the effect of miR-22 expression on the radiosensitivity of cervical cancer was investigated. First, miR-22 was either up- or downregulated to evaluate the regulation of the MYC-binding protein (MYCBP) in four cervical cancer cell lines (C-4I, SKG-II and SiHa). Notably, MYCBP expression was inversely associated with miR-22 induction. A dual-luciferase reporter gene assay revealed that miR-22 directly targets the MYCBP 3'-untranslated region. Subsequently, the level of human telomerase reverse transcriptase component (hTERT; an E-box-containing c-Myc target gene) was analyzed after the up- or downregulation of miR-22. Notably, miR-22-mediated repression of MYCBP reduced hTERT expression. In addition, the influence of miR-22 on radiosensitivity in C-4I, SKG-II and SiHa cells was examined using a clonogenic assay and in mouse xenograft models. Upregulation of miR-22 was associated with increased radiosensitivity. Furthermore, lentiviral transduction of miR-22 reduced the Ki-67 index while increasing the TUNEL index in xenograft tissue. The current findings indicate the potential utility of miR-22 in radiotherapy for cervical cancer.2020年03月, Oncology letters, 19(3) (3), 2213 - 2222, 英語, 国際誌研究論文（学術雑誌）
- Primary peritoneal carcinosarcomas which arise from extragenital locations are extremely rare. Carinosarcomas contain both carcinomatous and sarcomatous elements and can be mainly detected in the female genital tract. We herein report a case of primary peritoneal carcinosarcoma diagnosed by laparoscopic surgery and treated with olaparib. A 62-year-old woman referred to our hospital due to abdominal distension. From imaging findings, we suspected advanced primary peritoneal carcinoma, and laparoscopic surgery was thereafter performed. The pathological diagnosis was carcinosarcoma, and the patient received chemotherapy with docetaxel and carboplatin. After three cycles of chemotherapy, the interval debulking surgery was attempted but resulted in suboptimal results. Because the bilateral ovaries were observed with a normal size and normal findings, we considered that the most likely diagnosis was primary peritoneal carcinosarcoma. After the additional chemotherapy and a 6-month observation period, the tumor relapsed. The patient received chemotherapy again, and the peritoneal carcinosarcoma was judged to be a platinum-sensitive tumor. Oral administration of olaparib was thus initiated. Although a dose reduction was needed due to anemia, olaparib was effective, and the patient could continue the drug for another 7 months. This is the first report of primary peritoneal carcinosarcoma treated with olaparib and shows that it could be a treatment option for platinum-sensitive tumors.2020年, Case reports in obstetrics and gynecology, 2020, 9106390 - 9106390, 英語, 国際誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2019年10月, 産婦人科の進歩, 71(4) (4), 419 - 419, 日本語当院における子宮頸癌に対するベバシズマブの使用経験
- (一社)日本産科婦人科内視鏡学会, 2019年08月, 日本産科婦人科内視鏡学会雑誌, 35(Suppl.I) (Suppl.I), 281 - 281, 日本語
- OBJECTIVE: Our purposes of this study were to characterize a group of bulky cervical cancer patients who underwent a nerve sparing radical hysterectomy (NSRH) with or without neoadjuvant chemotherapy (NAC), to compare surgical outcomes and the preservation of bladder function, and to compare prognoses. RESULTS: Fifty-three patients had NSRH without NAC (Group A), and 33 patients had NSRH after NAC (Group B). With regard to prognostic factors, there was only a significant difference between both groups with regard to lymph node metastasis (15% vs 42%, P = 0.01). Moreover, bladder function in Group B patients improved to the same extent as the preoperative rate three months postoperatively. These data were similar to the results in Group A. With regard to overall survival, the 5-year survival rate was 98.1% (95% confidence interval (CI) 87.8-99.7) in Group A and 86.7% (95% CI 71.7-96.7) in Group B (P > 0.1). METHODS: We retrospectively identified 86 patients with cervical cancer who underwent NSRH at Osaka Medical College from May 2009 to November 2016. NAC was performed via balloon occluded arterial infusion. We extracted data on the patient's stage of progress, tumor volume, histological subtype, bleeding volume, urodynamic study results, and postoperative complications. The data were divided into two groups - those patients who received NAC and those who did not - and then compared. CONCLUSIONS: According to our analysis, NSRH surgery after NAC via balloon occluded arterial infusion brings beneficial results to patients with bulky IB2 to IIB cervical cancers.2019年08月, Oncotarget, 10(50) (50), 5207 - 5216, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, 日本語卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, 日本語卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 476 - 476, 日本語子宮頸がんに対する放射線治療後不全骨折発症のリスクについての検討
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 525 - 525, 日本語トラベクテジンの長期投与が可能であった平滑筋肉腫の二例
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, 日本語妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討
- 「産婦人科の進歩」編集室, 2019年05月, 産婦人科の進歩, 71(2) (2), 67 - 73, 日本語
- 「産婦人科の進歩」編集室, 2019年05月, 産婦人科の進歩, 71(2) (2), 230 - 230, 日本語
- (公社)日本産科婦人科学会, 2019年02月, 日本産科婦人科学会雑誌, 71(臨増) (臨増), S - 354, 日本語当院における稀少部位子宮内膜症10例の検討
- (公社)日本産科婦人科学会, 2019年02月, 日本産科婦人科学会雑誌, 71(臨増) (臨増), S - 352, 日本語子宮内膜症関連卵巣癌の病態解明を目的とした遺伝子発現解析
- (公社)日本産科婦人科学会, 2019年02月, 日本産科婦人科学会雑誌, 71(臨増) (臨増), S - 675, 日本語当科におけるがん治療後トータルヘルスケアの取り組み ホルモン補充療法の更年期症状への効果
- Matrix metalloproteinase-9 (MMP9) has been recognized to be an important factor in cancer invasion and metastasis. In contrast, decorin has been revealed to inhibit primary tumor development. The aim of the present study was to investigate the function of MMP9 and decorin in cervical cancer. Three experiments were performed to analyze the function of MMP9 and decorin in the invasion of cervical cancer by: i) Analyzing the expression of MMP9 and decorin by immunohistochemistry in 100 cervical specimens; ii) determining the concentration of decorin by an enzyme-linked immunosorbent assay (ELISA) using the human squamous cervical cancer cell line CaSki and human endometrial stromal cell line CRL4003 and iii) evaluating the invasion ability of CaSki cells in a cervical invasion model by an invasion assay. Immunohistochemistry revealed that MMP9 was overexpressed in microinvasive carcinoma (100.0%) but was less strongly expressed in normal or pre-malignant squamous epithelium (0-41.9%). In contrast, the activity of decorin in stroma adjacent to neoplastic cells was lower in microinvasive carcinoma (9.1%) compared with in normal or pre-malignant lesions (74.2-100.0%). An ELISA revealed that MMP9 released from CaSki cells resolved the decorin released from CRL4003 cells. An invasion assay demonstrated that the invasive ability of CaSki cells was suppressed by an MMP inhibitor, and decorin was released from CRL4003 cells. These data suggested that decorin prevented the invasion of malignant cells in uterine cervical cancer; however, MMP9 promotes cell invasion by destroying decorin.2019年01月, Oncol Lett, 17(1) (1), 1306 - 1312, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Ovarian granulosa cell tumors (GCTs) are divided into adult GCT (AGCT) and juvenile GCT (JGCT). The AGCT is more common type, conversely, less than 5% of tumors are the JGCT and occur in mainly premenarchal girls and in women younger than 30 years. Although JGCT have different histologic features compared to AGCT, the two types have similar imaging features because they have similar gross appearance. Therefore, it is difficult to distinguish two types by radiologic findings. In addition, it has not been described about the growth rate of JGCTs in past literatures. The aims of this report were to describe a case of rapidly growing JGCT arising in adult with difficulty in diagnosing and to review the literatures. CASE PRESENTATION: A 38-year-old woman, presented with abdominal distension and frequent urination, was found to have a pelvic mass measuring approximately 12 cm on ultrasonography. On magnetic resonance imaging (MRI), right ovarian multiloculated cystic mass accompanied with hemorrhagic foci was demonstrated. Although the presumptive diagnosis of GCT was made based on MR findings, the intraoperative differential diagnoses included GCT, yolk sac tumor or malignant mucinous tumor due to cytologic atypia and lack of the typical findings for AGCT such as nuclear grooves and Call-Exner bodies. As a result, abdominal simple total hysterectomy, bilateral oophoro-salpingectomy, partial omentectomy and appendectomy were performed. Moreover, she had a history of laparoscopic uterine myomectomy about one year before, and during that surgery bilateral ovaries were found to be macrospically normal. Therefore, it was suspected the tumor became enlarged within the short period of time. CONCLUSIONS: Even though it is difficult to distinguish two types of GCT by imaging findings, in some cases without typical findings for AGCT pathologically, MRI could provide useful information in accurately diagnosing JGCT. Moreover, in this case, the tumor growth rate seemed to be rapid regardless of its borderline malignant potential. It may be related with nuclear atypia and high mitotic rate of the tumor.2018年12月, J Ovarian Res, 11(1) (1), 100 - 100, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVE: We report a balloon-occluded arterial infusion therapy with an original four-lumen double-balloon catheter (4L-DB) which allows for the efficient injection of an anticancer agent at a high concentration to the target spot for patients with locally advanced uterine cervical cancer. METHODS: One hundred and forty-three patients with locally advanced cervical cancer treated with neoadjuvant intra-arterial chemotherapy (NAIAC) or a primary radical hysterectomy (PRH) were retrospectively assessed. The patients in the NAIAC group received irinotecan 70 mg/m2 intravenously on day 1 and 8 and cisplatin 70 mg/m2 intra-arterially using the 4L-DB on day 2 of a 21-day course, and two courses were performed in principle. The radical hysterectomy was performed within 6 weeks after NAIAC. RESULTS: Ninety-four patients were treated with NAIAC, and 49 patients undertook a PRH. The response rate of NAIAC on MRI was 92.6%. Fourteen patients (14.6%) had no evidence of cancer cells on pathologic diagnoses. The NAIAC group had a longer disease-free survival than the PRH group (p=0.02); however, the overall survival was not significantly different. The relative risk (RR) for recurrence was higher in patients with lymph node metastasis (RR, 4.31; 95% CI, 2.23-8.43) and lower in those who underwent NAIAC (RR, 0.30; 95% CI, 0.14-0.68). CONCLUSION: Our results with NAIAC using the 4L-DB catheter in locally advanced cervical cancer indicates beneficial effects on primary lesions and improves disease-free survival.2018年12月, Oncotarget, 9(102) (102), 37766 - 37776, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- A 33-year-old woman, gravida two para one, at 31 weeks of gestational age experienced sudden onset of left lower quadrant pain and underwent unenhanced pelvic MRI. On fast imaging employing steady state precession (FIESTA) sequence images, a marked difference was observed in the diameters of the right and left ovarian veins. The right ovarian vein was torturous and dilated, measuring 35 mm in diameter, while the left ovarian vein was thin and linear, measuring 7 mm in diameter. The left ovary showed no apparent swelling or hemorrhage, but was suspected to have been shifted anteriorly. The patient underwent explorative laparotomy and was found to have left ovarian torsion. A difference in diameter of the ovarian veins, with thinning of the twisted side and compensatory dilatation of the contralateral side for drainage of increased uterine blood flow, may be a useful imaging sign for the diagnosis of ovarian torsion during pregnancy.2018年12月, Radiol Case Rep, 14(3) (3), 324 - 327, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Nature Publishing Group, 2018年12月, Scientific Reports, 8(1) (1), 8872 - 8872, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Objective: The histological tumor grade is a strong predictor of nodal metastasis in endometrial cancer; as such, an accurate pre- or intraoperative diagnosis is important for performing lymphadenectomy. Methods: Ninety-one patients with endometrioid endometrial cancer were imaged on DW-MRI with the apparent diffusion coefficient (ADC) calculated and a frozen section (FS) diagnosis made before and at hysterectomy. The diagnostic accuracy for predicting the tumor grade for diffusion weighted magnetic resonance inaging (DW-MRI) and the FS diagnosis compared to the ultimate histologic status was analyzed. Results: Among 91 patients with endometrioid endometrial cancer, high-grade (endometrioid G3) tumors had lower ADC values than low-grade (endometrioid G1/2) tumors. The cut-off of the mean ADCmean values for predicting high-grade tumors resulted in 743×10-6 mm2/sec according to the receiver operating characteristic curve. The true positive rates of ADC values and FSs for the prediction of high-grade tumors did not differ to a statistically significant extent (73.3% vs. 66.7%, p=0.7), however, the true negative rate of ADC values for the prediction of low-grade tumors was significantly lower than that of the FSs (64.5% vs. 98.7%, p=0.01). The kappa statistics of ADC values and FSs were 0.23 and 0.73, respectively. Of note, all five patients with high-grade tumors for whom intraoperative FSs indicated low-grade tumors were predicted to have high-grade tumors on preoperative DW-MRI. Conclusion: A FS diagnosis is more suitable for predicting high-grade tumors than DW-MRI; however, physicians should pay close attention to tumors with low ADC values on preoperative DW-MRI.2018年11月, Oncotarget, 9(93) (93), 36575 - 36584, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本女性医学学会, 2018年10月, 日本女性医学学会雑誌, 26(Suppl.) (Suppl.), 119 - 119, 日本語内臓脂肪と子宮体癌の臨床病理学的特徴の関係
- According to the sentinel node biopsy (SNB), systematic pelvic lymph node dissection (PLND) may not be needed for patients with early-stage endometrial cancer. On the other hand, imaging technology including fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) has been developing worldwide. The aim of this study was to evaluate the combined diagnostic accuracy of FDG PET/CT and SNB in the prediction of pelvic lymph node metastasis in endometrial cancer patients.One hundred twenty-one patients with endometrial cancer underwent FDG PET/CT before hysterectomy and received SNB followed by systematic PLND. Univariate and multivariate analyses were performed to compare the diagnostic accuracy of FDG PET/CT and SNB in the prediction of pelvic node metastasis to the ultimate histologic status.FDG PET/CT had lower sensitivity (36.8% versus 57.9%, P = .1) and a higher specificity (96.4% versus 84.8%, P < .01) than SNB. The kappa statistics of FDG PET/CT and SNB were 0.37 (95% CI, 0.15-0.59) and 0.72 (95% CI, 0.53-0.90), respectively. The sensitivity of SNB was significantly higher than that of FDG PET/CT in all hemi-pelvises (HPs) in which the short axis of the largest metastatic lymph node was <5 mm in diameter (72.7% versus 18.2%, P = .01). In contrast, the sensitivity of FDG PET/CT was higher than that of SNB in all HPs in which the short axis of the largest metastatic lymph node was ≥5 mm in diameter (62.5% versus 37.5%, P = .2); however, the difference was not statistically significant. When the combined diagnosis of FDG PET/CT and SNB was made, the sensitivity and specificity were 84.2% and 82.1%, respectively.SNB was more useful for detecting lymph node metastasis than FDG PET/CT, especially in patients with small metastatic lymph nodes. The combined diagnosis of FDG PET/CT and SNB improves the sensitivity; PET-positive nodes should be dissected regardless of SNB status and HPs in which SNB was not detected should be dissected systematically regardless of FDG PET/CT status.2018年09月, Medicine (Baltimore), 97(38) (38), e - 12522, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 金原出版(株), 2018年09月, 産婦人科の実際, 67(9号) (9号), 1047 - 1051, 日本語[査読有り]研究論文（学術雑誌）
- (一社)日本産科婦人科内視鏡学会, 2018年08月, 日本産科婦人科内視鏡学会雑誌, 34(Suppl.I) (Suppl.I), 239 - 239, 日本語
- (一社)日本産科婦人科内視鏡学会, 2018年08月, 日本産科婦人科内視鏡学会雑誌, 34(Suppl.I) (Suppl.I), 185 - 185, 日本語
- BACKGROUND: It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other types being exceptionally rare. We report an extremely rare case of ovarian clear cell carcinoma arising from ovarian mature cystic teratoma. CASE PRESENTATION: The case was a 71-year-old woman with abdominal distention. Ultrasonography and magnetic resonance imaging showed a huge mass in her abdominal cavity. Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed FDG uptake not only in the pelvic tumor but also in the hepatic nodule, thus suggesting metastases. We performed a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and an omentectomy. The pathological diagnosis showed clear cell carcinoma of the right ovary which arose from the MCT with malignant transformation pT2aNXM1. Although the patient underwent chemotherapy, she died after 17 months. CONCLUSION: This case is histologically characteristic of the proof of transition from simple squamous epithelium via simple glandular epithelium to papillary change with atypia. This is the first case report of unaccompanied clear cell carcinoma arising from MCT reported in English literatures.2018年08月, J Ovarian Res, 11(1) (1), e - 74, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年07月, 日本臨床細胞学会雑誌, 57(4号) (4号), 213 - 216, 日本語尿細胞診が発見の契機となった膀胱内に発生した尖圭コンジローマの1例[査読有り]研究論文（学術雑誌）
- 2018年07月, 臨床婦人科産科, 72(7号) (7号), 721 - 725, 日本語重症妊娠悪阻からWernicke脳症とRefeeding症候群を発症した1例[査読有り]研究論文（学術雑誌）
- 2018年06月, 大阪母性衛生学会雑誌, 54(1号) (1号), 134 - 138, 日本語超緊急帝王切開術(グレードA)の院内システム構築後の課題 ワーキンググループ発足と病棟内での取り組み[査読有り]研究論文（学術雑誌）
- 2018年05月, 産婦人科の進歩, 70(2号) (2号), 89 - 96, 日本語卵巣悪性腫瘍合併妊娠の1例[査読有り]研究論文（学術雑誌）
- W.B. Saunders Ltd, 2018年05月, Placenta, 65, 1 - 6, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Impact Journals LLC, 2018年04月, Oncotarget, 9(32) (32), 22769 - 22784, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: In Japan, the rate of cervical cancer screening is remarkably low, especially among women in their twenties and thirties, when cervical cancer is now increasing dramatically. The aim of this study was to test whether a modified government reminder for 20-year-old women to engage in cervical cancer screening, acting through maternal education and by asking for a maternal recommendation to the daughter to receive the screening, could increase their participation rate. METHODS: In two Japanese cities, 20-year-old girls who had not received their first cervical cancer screening before October of fiscal year 2014 were randomized into two study arms. One group of 1,274 received only a personalized daughter-directed reminder leaflet for cervical cancer screening. In the second group of 1,274, the daughters and their mothers received a combination package containing the same reminder leaflet as did the first group, plus an additional informational leaflet for the mother, which requested that the mother recommend that her daughter undergo cervical cancer screening. The subsequent post-reminder screening rates of these two study arms were compared. RESULTS: The cervical cancer screening rate of 20-year-old women whose mothers received the information leaflet was significantly higher than that for women who received only a leaflet for themselves (11% vs 9%, P = 0.0049). CONCLUSIONS: An intervention with mothers, by sending them a cervical cancer information leaflet with a request that they recommend that their daughter receive cervical cancer screening, significantly improved their daughters' screening rate.2018年03月, Journal of epidemiology, 28(3) (3), 156 - 160, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年02月, 日本産科婦人科学会雑誌, 70(2) (2), 846, 日本語妊娠中子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会)報告
- 2018年02月, 日本産科婦人科学会雑誌, 70(2) (2), 846, 日本語分娩後1年以内の子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会)報告
- Systematic pelvic lymph node resection may not be needed for patients with cervical cancer, especially in the early stage, if the pre- or intraoperative diagnosis of lymph node status is correct. The aim of this study was to evaluate the diagnostic accuracy of pelvic lymph node metastasis for fluorodeoxyglucose-positron emission tomography/computed tomography (FDG PET/CT) and sentinel node biopsy (SNB) of cervical cancer patients.Forty-eight patients with cervical cancer were imaged with FDG PET/CT before radical hysterectomy and underwent an SNB followed by systematic pelvic lymph node dissection. The diagnostic accuracy for predicting pelvic node metastases for FDG PET/CT and SNB compared with the ultimate histologic status was analyzed.Among 96 hemi-pelvises (HPs) in 48 patients, pelvic lymph node metastases were obtained in 12 HPs. The sensitivity of pelvic node metastases for FDG PET/CT and SNB was 8.3% and 75.0%, respectively. The specificity for FDG PET/CT and SNB was 97.6% and 94.0%, respectively. The negative predictive value for FDG-PET/CT and SNB was 88.2% and 100%, respectively.SNB is more suitable for detecting pelvic node metastases than FDG PET/CT. The omission of systematic pelvic lymphadenectomy should be considered based on the findings of SNB, not FDG PET/CT.2018年, Medicine (Baltimore), 97(16) (16), e - 0410, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- In Japan, the trend for cervical cancer at younger ages has been increasing. As a countermeasure, the HPV vaccine was introduced as a routine vaccination in April 2013. However, the Ministry of Health, Labour and Welfare (MHLW) announced a "Suspension of its active inoculation recommendation for HPV vaccine" in June 2013. In 2016, 32 months after that suspension, we conducted survey via Internet and compared the results with our previous ones conducted at 9 and 23 months after suspension (in 2014 and 2015, respectively). We examined the 'time-dependent change' of the 'intention of mothers to inoculate their daughters with the HPV vaccine' in terms of efficacy of external decision-making support. 17.5% of mothers in the first survey replied that they would inoculate their daughters under the current circumstances, 12.1% in the second survey, and 6.7% in the third, showing a consistent decrease in willingness over time (p = 0.03, p < 0.01). If the government recommendation were to be reintroduced, 22.5% of mothers in the first survey replied they would inoculate their daughters, 21.0% in the second survey, which indicated no significant difference (p = 0.65) over the first interval; however, this was significantly decreased to 12.2% in the third survey (p < 0.01). Our study revealed that the intention to inoculate their daughters has been declining among Japanese mothers over time triggered by the suspension.2018年, Human vaccines & immunotherapeutics, 14(10) (10), 2497 - 2502, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: The examination of a sentinel lymph node (SLN), where lymph node metastasis first occurs, may be advocated as an alternative staging technique. The aim of this study was to evaluate the feasibility and detection rates of an SLN biopsy in patients with endometrial cancer. STUDY DESIGN: Two hundred and eleven patients with endometrial cancer underwent an SLN biopsy at hysterectomy using three kinds of tracers including 99m-technetium-labeled tin colloid (99mTc), indigo carmine and indocyanine green. Factors related to the side-specific detection rate, sensitivity and false negative rate were analyzed. RESULTS: The detection rates of the SLN biopsy using 99mTc, indigo carmine and indocyanine green were 77.9, 17.0 and 73.4%, respectively. The detection rate was lower in elderly patients (≥60 years) (67.9 vs 89.2%, p < 0.01), patients with >50% myometrial invasion (68.3 vs 85.2%, p < 0.01), patients with high-grade tumors (69.5 vs 84.9%, p < 0.01) and patients who underwent laparotomy (71.2 vs 84.9%, p < 0.01). There were no significant differences in body mass index. The sensitivity was not significantly different in any factor. However, the false negative rate was higher in patients with > 50% myometrial invasion (11.5 vs 1.2%, p < 0.01), high-grade tumors (13.3 vs 0.8%, p < 0.01) and who underwent laparotomy (12.2 vs 0.4%, p < 0.01). CONCLUSION: Patients who underwent laparoscopy with < 50% myometrial invasion and low-grade tumors not only have higher detection rates, but also have lower false negative rates. These patients may avoid systemic lymphadenectomy according to the status of the SLN biopsy.2018年, Int J Clin Oncol, 23(2) (2), 305 - 313, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- INTRODUCTION: The aim of this study was to investigate the effect of laparoscopic endometriotic cystectomy and vaporization on ovarian reserve. METHODS: We prospectively analyzed the serum level of anti-Mullerian hormone (AMH) in 62 patients at four different time points- preoperatively and at 1 month, 6 months, and 1 year postoperatively. Among the 62 cases, a bilateral cystectomy was performed in 10, bilateral vaporization in 16, a unilateral cystectomy in 24, and unilateral vaporization in 12. RESULTS: The rate of AMH decline after unilateral cystectomy or bilateral cystectomy was higher than that after unilateral vaporization or bilateral vaporization. Age and bilaterality were associated with an AMH decline at 1 month, and age alone was associated with an AMH decline at 1 year. Moreover, being older than 38 years of age and having a revised American Society for Reproductive Medicine score >80 were independent risk factors for the non-recovery of AMH. CONCLUSION: The rate of AMH decline after laparoscopic endometriotic vaporization is significantly lower than that after cystectomy. Both methods, however, have the potential to lower ovarian reserve, especially in cases of severe endometriosis or in patients older than 38 years of age.2018年, Asian J Endosc Surg, 11(1) (1), 23 - 29, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (一社)日本女性医学学会, 2017年10月, 日本女性医学学会雑誌, 25(Suppl.) (Suppl.), 167 - 167, 日本語卵巣癌患者における子宮内膜症癌化と脂質代謝の検討
- OBJECTIVE: In Japan, the possible adverse events upon HPV vaccination was widely reported in the media. MHLW announced the suspension of aggressively encouraging HPV vaccination in 2013, and inoculation rate has sharply declined. The aim of the present study was estimation of future cervical cancer risk. METHODS: The latest data on vaccination rate at each age in Sakai City were first investigated. The rate of experiencing sexual intercourse at the age of 12, 13, 14, 15, 16, 17 and throughout lifetime is assumed to be 0%, 1%, 2%, 5%, 15%, 25%, and 85% respectively. The cervical cancer risk was regarded to be proportional to the relative risk of HPV infection over the lifetime. The risk in those born in 1993 whom HPV vaccination was not available yet for was defined to be 1.0000. RESULTS: The cumulative vaccination rates were 65.8% in those born in 1994, 72.7% in 1995, 72.8% in 1996, 75.7% in 1997, 75.0% in 1998, 66.8% in 1999, 4.1% in 2000, 1.5% in 2001, 0.1% in 2002, and 0.1% in 2003. The relative cervical cancer risk in those born in 1994-1999 was reduced to 0.56-0.70, however, the rate in those born in 2000-2003 was 0.98-1.0, almost the same risk as before introduction of the vaccine. DISCUSSION: The cumulative initial vaccination rates were different by the year of birth. It is confirmed that the risk of future cervical cancer differs in accordance with the year of birth. For these females, cervical cancer screening should be recommended more strongly.2017年07月, Human vaccines & immunotherapeutics, 13(7) (7), 1700 - 1704, 英語, 国際誌研究論文（学術雑誌）
- 2017年07月, MEDICINE, 96(27) (27), e7502, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The degree of peritoneal dissemination and chemotherapy-resistant tumors is related to the prognosis in patients with advanced-stage ovarian cancer. The epithelial-mesenchymal-transition (EMT) is a multifaceted pathological program that endows cancer cells with the ability to invade and disseminate. CD24 is frequently overexpressed in various human cancers and is correlated with a poor prognosis. We herein examined the functions of CD24 in human ovarian cancer cell lines and evaluated how it contributes to the molecular mechanism underlying the regeneration of cancer stem-like cells (CSCs) through the EMT mechanism in ovarian carcinoma. We demonstrated that CD24 was expressed in 70.1% of primary ovarian carcinoma tissues, which were obtained from 174 patients, and that the expression of CD24 was an independent predictor of survival in patients with ovarian cancer. The expression of CD24 has been found to be correlated with the FIGO stage, presence of peritoneal and lymph node metastasis. CD24 induces the EMT phenomenon, which is involved in cell invasion, the highly proliferative phenotype, colony formation and which is associated with cisplatin resistance and the properties of CSCs, via the activation of PI3K/Akt, NF-κB and ERK in Caov-3 cisplatin-resistant cell lines. CD24-positive ovarian carcinomas have been shown to have a greater potential for intra-abdominal tumor cell dissemination in in vivo models. Our findings suggest that CD24 induced the EMT phenomenon in ovarian cancer, and that CD24 amplified cell growth-related intracellular signaling via the PI3K/Akt and MAPK pathways by affecting the EMT signal pathways. We believe that CD24 is a key molecule of metastatic progression in the EMT phenomenon and a promising therapeutic target for advanced ovarian cancer.2017年06月, Oncology reports, 37(6) (6), 3189 - 3200, 英語, 国際誌研究論文（学術雑誌）
- Mary Ann Liebert Inc., 2017年06月, Journal of Gynecologic Surgery, 33(3) (3), 105 - 110, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- AIM: The aim of this study was to investigate whether FOXO1 and FOXO3 mRNA expression in granulosa cells is the cause of unexplained infertility. METHODS: Thirty-one patients aged <40 years (13 with unexplained infertility and 18 with male partner infertility as a control group) whose serum anti-Müllerian hormone level was >0.5 ng/μL were enrolled in the study. All patients underwent oocyte retrieval under a short protocol from June 2012 to October 2013. Real-time PCR was carried out using mRNA extracted from granulosa cells retrieved from mature follicles. We compared FOXO1 and FOXO3 mRNA expression ratios in granulosa cells between the unexplained infertility group and the male infertility group. The relation between FOXO1 and FOXO3 mRNA expression ratios in granulosa cells and assisted reproduction technology clinical outcome was also examined. RESULTS: FOXO3 mRNA expression ratio was significantly lower in the unexplained infertility group than in the male infertility group. Moreover, FOXO3 mRNA expression ratio showed a positive correlation with both the number of retrieved oocytes and serum anti-Müllerian hormone level. A positive correlation was also identified between FOXO1 mRNA expression and total dose of hMG. As well, the number of retrieved oocytes in the unexplained infertility group was statistically lower than that in the male infertility group. CONCLUSION: A lower FOXO3 mRNA expression in granulosa cells leads to poor oocyte development in patients with unexplained infertility undergoing controlled ovarian stimulation for in vitro fertilization-embryo transfer.2017年06月, The journal of obstetrics and gynaecology research, 43(6) (6), 1021 - 1028, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Our objective was to determine the feasibility and detection rates and clarify the most effective combination of injected tracer types for sentinel lymph node (SLN) mapping in uterine cervical cancer in patients who have undergone laparoscopic surgery or neoadjuvant chemotherapy (NAC). METHODS: A total of 119 patients with cervical cancer underwent SLN biopsy at radical hysterectomy using three types of tracers. The various factors related to side-specific detection rate, sensitivity, and false negative (FN) rate were analyzed. RESULTS: The SLN detection rates using 99m-technetium ((99m)Tc)-tin colloid, indigo carmine, and indocyanine green (ICG) were 85.8%, 20.2%, and 61.6%, respectively. The patients with ≥2-cm-diameter tumors and those who received NAC had lower detection rates than those with <2-cm-diameter tumors (75.7% vs. 91.5%, p<0.01) and those who did not receive NAC (67.9% vs. 86.3%, p<0.01), respectively. Laparoscopic procedures had a higher detection rate than laparotomy (100.0% vs. 77.1%, p<0.01). No factors significantly affected the sensitivity; however, the patients with ≥2-cm-diameter tumors (86.0% vs. 1.4%, p<0.01), NAC (19.4% vs. 2.2%, p<0.01), and those who underwent laparotomy (7.4% vs. 0%, p<0.01) had an unfavorable FN rate. CONCLUSION: Among the examined tracers, (99m)Tc had the highest detection of SLN mapping in patients with uterine cervical cancer. Patients with local advanced cervical cancer with/without NAC treatment might be unsuited for SLN mapping. SLN mapping is feasible and results in an excellent detection rate in patients with <2-cm-diameter cervical cancer. Laparoscopic surgery is the best procedure for SLN detection in patients with early-stage disease.2017年03月, Journal of gynecologic oncology, 28(2) (2), e13, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本産科婦人科学会, 2017年02月, 日本産科婦人科学会雑誌, 69(2) (2), 664 - 664, 日本語Micro RNA-22を介した子宮頸癌の分子標的治療への応用
- BACKGROUND: PD-0332991, the selective cyclin-dependent kinase 4/6 inhibitor palbociclib, causes cell cycle arrest by inhibiting phosphorylation of retinoblastoma (Rb) protein. The aim of this study was to evaluate the therapeutic potential of PD-0332991 in endometrial cancer. METHODS AND FINDINGS: Four human endometrial cancer cell lines, ECC, HEC1A, HEC108 and TEN, were treated with PD-0332991 and their function was evaluated. In vivo, the therapeutic efficacy was evaluated in a model of subcutaneous endometrial cancer. An immunohistochemical analysis was performed in 337 endometrial cancer specimens. A proliferation assay revealed that 2 of the 4 cell lines that expressed Rb were sensitive to PD-0332991 with an IC50 of 0.65 μM (HEC1A) and 0.58 μM (HEC108), respectively. Both cell lines had G0/G1 cell cycle arrest after treatment with PD-0332991 according to flow cytometry. In vivo, PD-0332991 had antitumoral efficacy with a reduction in the activity of Ki67 and phosphorylation of Rb. Immunohistochemical analyses revealed that the positive rate of Rb was 67.7%, however, there was no significant relationship between the expression levels of Rb and the tumor grade. CONCLUSIONS: PD-0332991 had therapeutic potential against endometrial cancer cell lines expressing Rb protein. Our immunohistochemical analysis revealed that approximately 70% of patients with endometrial cancer might have therapeutic indications for PD-0332991. Of note, the tumor grade had no impact on the indications for treatment.2017年, PloS one, 12(5) (5), e0177019, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2017年, 産婦人科の進歩, 69(2) (2), 145 - 150, 日本語
結核性腹膜炎は特異的な臨床所見に乏しく，肺病変を有しない症例を半数で認める．今回，腹腔鏡下手術により結核性腹膜炎の診断に至った症例を経験したので報告する．症例は66歳，5経妊3経産で，腹部膨満感と持続する微熱を主訴に受診した．血液検査で炎症反応とCA125値の著明な上昇を認め，画像検査で大量の腹水貯留と腹膜肥厚，さらに大網に播種病巣を認めた．咳嗽や血痰などの肺結核症状は認めず，喀痰および腹水穿刺の細菌培養検査で結核菌は陰性であった．以上の結果より，癌性腹膜炎との鑑別診断のために腹腔鏡手術を施行した．腹水から異型細胞を認めなかったが，腹水中の結核菌培養陽性とadenosine deaminase（ADA）が89 U/l と高値であった．病理検査では乾酪壊死巣を伴う類上皮細胞性肉芽腫を認め，結核性腹膜炎の確定診断に至り，抗結核薬投与を開始した．腹水貯留による腹部膨満感を生じる症例には，卵巣悪性腫瘍をはじめとした骨盤内悪性腫瘍や，肝疾患，感染症などが鑑別診断に挙げられる．特異的な臨床所見に乏しい本症例は，診断的腹腔鏡下手術が有用であった．〔産婦の進歩69（2）：145-150，2017（平成29年5月）〕
- 近畿産科婦人科学会, 2017年, 産婦人科の進歩, 69(4) (4), 355 - 359, 日本語
腹膜妊娠は異所性妊娠のなかで1％以下の頻度であり，比較的稀な疾患である．腹膜妊娠は大量出血を起こす可能性があるが，術前の診断は困難であることが多い．今回，われわれは異所性妊娠の破裂疑いで腹腔鏡下手術を施行し，術中に膀胱子宮窩腹膜への原発性腹膜妊娠と診断し腹腔鏡下に治療し得た症例を経験したので報告する．症例は29歳1経妊1経産．血中hCG高値（40907 mIU/ml）のため近医より精査加療目的に当科を紹介受診予定であったが，腹痛を認めたため当院救急外来を受診した．診察所見では腹膜刺激症状を認めた．超音波で子宮内に胎嚢を認めず，腹腔内出血，子宮体下部前面に約18.6 mmの胎児様像を認めた．また血中hCG値は5742 mIU/mlまで低下していた．異所性妊娠破裂疑いとして同日に緊急腹腔鏡下手術を施行した．腹腔内所見で多量の血液貯留を認めた．両側卵巣・卵管には異常所見を認めず，左円靭帯から膀胱子宮窩腹膜の部位に凝血塊を伴った胎嚢を認めたため周囲腹膜を含めて摘出した．摘出部位を病理組織に提出したところ，絨毛組織を認め異所性妊娠と矛盾しない結果であった．術後経過は良好であり術後6日目で退院した．その後，外来管理で血中hCG値の陰性化を確認した．〔産婦の進歩69（4）：355-359，2017（平成29年10月）〕
- Aim: To investigate which risk factors contribute to a lower oocyte retrieval ratio in women who are receiving controlled ovarian hyperstimulation. Methods: The authors retrospectively analyzed 329 in vitro fertilization (IVF) cycles under controlled ovarian hyperstimulation by using a gonadotropin-releasing hormone antagonist or agonist at Osaka Medical College, Japan. The patients were classified into five groups: advanced age, male infertility, severe endometriosis, tubal infertility, and unexplained infertility. The primary outcomes were the patients' age, oocyte retrieval ratio, serum basal follicle-stimulating hormone, total dose of gonadotropin, and the clinical outcome. A secondary outcome was the stepwise multivariate logistic regression analysis to assess the factors associated with the failure of oocyte retrieval. Results: The oocyte retrieval ratio declined significantly with the patient's age. The ratio of endometriosis in unsuccessful cases was significantly higher than that in successful cycles. Advanced age and endometriosis were the factors that were significantly associated with a lowered oocyte retrieval rate. Conclusion: Advanced age and endometriosis are high-risk factors that contribute to oocyte retrieval failure in infertile patients who are receiving IVF treatment.2017年01月, Reproductive medicine and biology, 16(1) (1), 40 - 44, 英語, 国内誌研究論文（学術雑誌）
- AIM: In Japan, the rate of routine cervical cancer screening is quite low, and the incidence of cervical cancer has recently been increasing. Our objective was to investigate ways to effectively influence parental willingness to recommend that their 20-year-old daughters undergo cervical cancer screening. METHODS: We targeted parents whose 20-year-old daughters were living with them. In fiscal year 2013, as usual, the daughter received a reminder postcard several months after they had received a free coupon for cervical cancer screening. In fiscal year 2014, the targeted parents received a cervical cancer information leaflet, as well as a cartoon about cervical cancer to show to their daughters, with a request that they recommend to their daughter that she undergo cervical cancer screening. The subsequent screening rates for fiscal years 2013 and 2014 were compared. RESULTS: The cervical cancer screening rate of 20-year-old women whose parents received the information packet in fiscal year 2014 was significantly higher than for the women who, in fiscal year 2013, received only a simple reminder postcard (P < 0.001). As a result, the total screening rate for 20-year-old women for the whole of the 2014 fiscal year was significantly increased over 2013 (P < 0.001). CONCLUSION: For the first time, we have shown that the parents of 20-year-old daughters can be motivated to recommend that their daughters receive their first cervical cancer screening. This was achieved by sending a cervical cancer information leaflet and a cartoon about cervical cancer for these parents to show to their daughters. This method was significantly effective for improving cervical cancer screening rates.2016年12月, The journal of obstetrics and gynaecology research, 42(12) (12), 1802 - 1807, 英語, 国際誌研究論文（学術雑誌）
- Bone marrow-derived endothelial progenitor cells (EPCs) have been shown to contribute to not only angiogenesis in ischemic tissue but also neovascularization in uterine endometrium formation. Reduced neovascularization and elevation of serum soluble Flt1, a functional blockage of VEGF, in the development of placenta is thought to be one of the major causes of repeated miscarriages in gestation. We then examined whether transfusion of VEGF-expressing extrinsic EPCs prevented frequent miscarriage via its promotional effect on neovascularization with a VEGFeNOS signaling pathway in a mouse miscarriage model. The results showed that systemic EPC transfusion significantly reduced the rate of miscarriage, and EPCs were frequently observed in the miscarriage placenta. In contrast, only a few EPCs were detected in the placenta of normal gestation. The vascular pattern was irregular, and vessel size was small in the miscarriage placenta compared with that of normal gestation. The placental vascular pattern in miscarriage tended to be normalized with increased vessel size up to a similar level as normal gestation by EPC recruitment. For the mechanistic insight, since soluble Flt1 inhibits EPC functions, it was suggested that the increased soluble Flt1 could suppress the recruited EPC functional activity in the miscarriage placenta. In vitro experiments by soluble Flt1 treatment in cultured EPCs suggested that the vascular abnormality could be partly due to the inhibition of eNOS expression by the increased amounts of soluble Flt1. These findings from animal experiments indicated that autologous EPC therapy may be a novel therapy to prevent miscarriage in high-risk pregnancies, such as preeclampsia.2016年12月, Cell transplantation, 25(12) (12), 2187 - 2197, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Mothers' attitudes in Japan regarding cervical cancer screening correlates with intention to recommend cervical cancer screening for daughters.BACKGROUND: Cervical cancer and its precancerous lesions caused by human papilloma virus (HPV) are steadily increasing in women in Japan. In comparison with women in other resource-rich countries, young women in Japan have a dismally low screening rate for cervical cancer. Our preliminary research has shown that 20-year-old women in Japan usually ask their mothers for advice regarding their initial cervical cancer screening. The objective of our current research is to determine the social factors among mothers in Japan that are causing them to give advice to their daughters regarding the HPV vaccine and cervical cancer screening. METHODS: The survey's targets were mothers who had 20-year-old daughters. We recruited respondents from the roster of a commercial internet survey panel. We analyzed for correlations between a mother's knowledge concerning cervical cancer, her recent cancer screening history, and the advice she gave to her daughter regarding cervical cancer screening. RESULTS: We obtained 618 valid answers to the survey. Compared with mothers who did not get screening, mothers who had cervical cancer screening had significantly more knowledge about cervical cancer and its screening (p < 0.05). The daughters of mothers with recent screening had received HPV vaccination more often than those of mothers without recent screening (p = 0.018). Mothers with recent screening histories tended more often to encourage their daughters to have cervical cancer screening (p < 0.05). When mothers were properly educated concerning cervical cancer and its screening, they were significantly more likely than before to recommend that their daughters have it (p < 0.0001). CONCLUSIONS: In young Japanese women, given the important role their mothers have in their lives, it is probable that we could improve their cervical cancer screening rate significantly by giving their mothers better medical information, and a chance to experience cervical cancer screening for themselves.2016年10月, International journal of clinical oncology, 21(5) (5), 962 - 968, 英語, 国内誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2016年10月, 産婦人科の進歩, 68(4) (4), 492 - 492, 日本語リンパ浮腫に対する術前リンパシンチグラフィーの有用性について
- Development of an efficient strategy to improve HPV immunization coverage in Japan.BACKGROUND: In Japan, new HPV immunizations have dropped dramatically after repeated adverse media reports and a June 2013 temporary suspension of the government's recommendation for the vaccine. The aim of the present study was to develop an efficient strategy to improve HPV immunization coverage across Japan. METHODS: We conducted an internet survey in Japan of mothers of 12-16 year-old girls who were unvaccinated as of May, 2015. The goal was to gather behavioral information from the mothers to develop a strategy for improving Japanese HPV immunization coverage. RESULTS: Valid survey answers were obtained from 2060 mothers. The survey found that a hypothetical restart of a governmental recommendation for the vaccine would induce 4.1 % of all the mothers surveyed to be more likely to encourage vaccination of their daughters, without any other preconditions. This initial result would be followed by a moderate spread of vaccinations to these daughters' close friends and acquaintances, hypothetically resulting in a total vaccination rate of 21.0 % of the targeted age-eligible girls. As a second critical step for improving vaccinations, an educational information sheet integrating the concepts of behavioral economics for changing behaviors was found to be significantly effective for persuading mothers with poorer decision-making facilities, who would otherwise prefer to wait to first see the vaccination of other girls of the same age as their daughter. CONCLUSIONS: Following what we foresee as the inevitable restart of the Japanese government's recommendation for receiving the HPV vaccine, we expect to first see vaccinations occurring in a very small group of girls, the daughters of the most willing mothers, which will be roughly 4 % of those eligible for government paid vaccinations. This will be followed by the spread of vaccinations outward through these girls' circle of friends and acquaintances, and, finally, to the daughters of the most skeptical mothers, those who would await the return of new vaccine safety results from a large group of similarly-aged girls. As a critical step in improving HPV vaccine coverage in Japan, an educational information sheet that integrates the concepts of behavioral economics for changing behaviors can be employed to persuade mothers with poor decision-making facilities.2016年09月, BMC public health, 16(1) (1), 1013 - 1013, 英語, 国際誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2016年08月, 産婦人科の進歩, 68(3) (3), 350 - 353, 日本語
- (公社)日本婦人科腫瘍学会, 2016年06月, 日本婦人科腫瘍学会雑誌, 34(3) (3), 431 - 431, 日本語子宮体癌に対する腹腔鏡下傍大動脈リンパ節郭清の有用性に関する多施設共同研究
- Sertoli-Leydig細胞腫は性索間質性腫瘍に属する．非常にまれな腫瘍で全卵巣腫瘍の0.2～0.6%を占める．好発年齢は比較的若年の25歳前後で，30歳以下が75%を占めるのに対して，閉経後は10%に過ぎない．今回われわれは閉経後，男性化徴候を示したSertoli細胞腫の症例を経験したので報告する．症例は67歳，未経妊，子宮内膜症，痛風，高血圧症，C型肝炎の既往がある．腹部膨満感を主訴として前医を受診した．子宮頸部細胞診はNILMで異常なかったが，年齢に比して，表層～中層細胞優位な細胞像であった．骨盤MRI画像上，充実部を主体とした嚢胞成分を含む長径約25cm大の巨大骨盤内腫瘍を認めた．子宮は正常であったが内膜肥厚を認め，血中エストラジオール163.6 pg/ml，テストステロン5.6 ng/mlと高値であった．以上からホルモン産生卵巣腫瘍を疑い，腹式単純子宮全摘出術，両側付属器摘出術，大網部分切除術を施行した．病理組織標本では，腫瘍は嚢胞を有する右卵巣由来の充実性腫瘍であり，Sertoli細胞が胞巣状，索状に配列していた．核分裂像は1-2/10HPFと少なかった．腫瘍細胞はα-vimentin，PgRが陽性で，EMA（epithelial membrane antigens），CEA，AE1/AE3，CK7，CK20，CD30，AFP，ERが陰性，MIB-1は約1%が陽性であった．明らかなLeydig細胞は認められなかった．以上から右卵巣腫瘍，Sertoli細胞腫（中分化型：境界悪性腫瘍），pT1a NX M0 FIGO stage 1A期と診断した．血中のエストラジオール，テストステロンは術後速やかに陰性化した．術後補助療法なしで1年10カ月経過観察中であるが現在再発徴候なく経過中である．〔産婦の進歩68（1）：36-41，2016（平成28年2月）〕近畿産科婦人科学会, 2016年, 産婦人科の進歩, 68(1) (1), 36 - 41, 日本語
- Intestinal obstruction in pregnancy is rare and is mainly caused by prior pelvic surgery. We herein report a case of intestinal obstruction in a pregnant female with a history of laparoscopic myomectomy, who presented with hypogastric pain, abdominal distension, and vomiting at 26 weeks of gestation. A simple intestinal obstruction was diagnosed by MRI. Conservative treatments, including intravenous hyperalimentation and the placement of an ileus tube, were provided and her abdominal symptoms improved for 14 days. After restarting oral intake, she had no abdominal symptoms. She gave birth to a 2,146 g female infant by caesarean section at 37 weeks and 1 day of gestation. Although an area of cicatrization, which was thought to have been the starting point of the occlusion that caused the intestinal obstruction, was found, the excision of the small intestine was not necessary. Her postoperative course was uneventful. Intestinal obstruction requires a prompt diagnosis and aggressive intervention may be necessary to minimize the morbidity and mortality associated with this rare complication of pregnancy. MRI can be safely used during pregnancy to diagnose intestinal obstruction and intravenous hyperalimentation may improve the maternal and fetal prognoses.2016年, Case reports in obstetrics and gynecology, 2016, 8704035 - 8704035, 英語, 国際誌研究論文（学術雑誌）
- CD24, a small heavily glycosylated mucin-like glycosyl-phosphatidylinositol-anchored cell surface protein, plays an important role in the carcinogenesis of various human malignancies. However, its function in cervical cancer remains unclear. The aim of the present study was to evaluate the expression of CD24 clinicopathologically and to analyze its functional behavior biologically in cervical cancer. A total of 117 uterine cervical cancer tumors were immunohistochemically analyzed using a CD24 monoclonal antibody on paraffin blocks. We also examined whether CD24 enhanced the invasive activity or the Akt, ERK, NF-κB and MMP activity in a uterine cervical cancer cell line (CaSki) by a western blot analysis. The patients with enhanced CD24 expression had a higher rate of advanced clinical stage (50 vs. 16.5%, p<0.01), lymph node metastasis (34.6 vs. 14.3%) and lymphovascular involvement (65.4 vs. 20.4%, p=0.01), and a poor overall and disease-free survival (5-year survival rate: 62 vs. 86%, p=0.03). CD24 overexpression in CaSki cells resulted in activation of Cell Signaling proteins, including Akt, ERK, NF-κB and MMP-9. An invasion assay showed that CD24 overexpression in CaSki cells led to increased invasion ability. The CD24 overexpression also increased mRNA expression of Slug but not Snail. Moreover, the CD24 overexpression also decreased expression of E-cadherin and increased N-cadherin protein levels. Increased expression of CD24 may be associated with tumor progression and prognosis in patients with uterine cervical cancer. CD24 expression may therefore be used not only as a prognostic marker in uterine cervical cancer, but also as a target for the development of new therapeutic approaches.2015年11月, Oncology reports, 34(5) (5), 2282 - 8, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: A current working model for the metastatic process of ovarian carcinoma suggests that cancer cells are shed from the ovarian tumor into the peritoneal cavity and attach to the layer of mesothelial cells that line the inner surface of the peritoneum, and several studies suggest that hepatocyte growth factor (HGF) plays an important role in the dissemination of ovarian cancer. Our objectives were to evaluate the HGF expression of ovarian cancer using clinical data and assess the effect of HGF secreted from human ovarian cancer cells to human mesothelial cells. METHODS: HGF expression was immunohistochemically evaluated in 165 epithelial ovarian cancer patients arranged as tissue microarrays. HGF expression in four ovarian cancer cell lines was evaluated by using semi-quantitative polymerase chain reaction, Western blotting and enzyme-linked immunosorbent assay. The effect of ovarian cancer cell derived HGF to the human mesothelial cells was assessed by using morphologic analysis, Western blotting and cell invasion assay. The effect of HGF on ovarian cancer metastasis was assessed by using in vivo experimental model. RESULTS: The clinical data showed a significantly high correlation between the HGF expression and the cancer stage. The in vivo and in vitro experimental models revealed that HGF secreted by ovarian cancer cells induces the mesothelial-to-mesenchymal transition and stimulates the invasion of mesothelial cells. Furthermore, manipulating the HGF activity affected the degree of dissemination and ascite formation. CONCLUSIONS: We demonstrated that HGF secreted by ovarian cancer cells plays an important role in cancer peritoneal implantation.2015年11月, Gynecologic oncology, 139(2) (2), 345 - 54, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT₃ receptor with/without aprepitant in patients with gynecological cancer treated with the TC (paclitaxel and carboplatin) regimen of MEC. METHODS: We enrolled 38 patients diagnosed with gynecologic cancer and scheduled to receive the TC regimen. The patients were randomly assigned to receive a 5-HT₃ receptor antagonist, either palonosetron in the first cycle followed by granisetron in the second cycle or vice versa. In the third cycle, all patients received a combination of the 5-HT₃ receptor and dexamethasone with/without aprepitant. RESULTS: When three drugs were administered, palonosetron consistently produced an equivalent complete response (CR) rate to granisetron in the acute phase (89.5% vs. 86.8%, p=0.87) and delayed phase (60.5% vs. 65.8%, p=0.79). With regard to the change in dietary intake, palonosetron exhibited similar efficacy to granisetron in the acute phase (92.1% vs. 89.4%, p=0.19) and delayed phase (65.7% vs. 68.4%, p=0.14). However, in the delayed phase, the addition of aprepitant therapy with a 5-HT₃ receptor antagonist and dexamethasone produced a higher CR rate than a 5-HT₃ receptor antagonist with dexamethasone (93.3% vs. 47.8%, p<0.001) and allowed the patients to maintain a higher level of dietary intake (93.3% vs. 56.5%, p<0.001). CONCLUSION: The addition of aprepitant therapy was more effective than the control therapy of a 5-HT₃ receptor antagonist, and dexamethasone in gynecological cancer patients treated with the TC regimen.2015年10月, Journal of gynecologic oncology, 26(4) (4), 311 - 9, 英語, 国際誌研究論文（学術雑誌）
- Purpose: To investigate the effect of moderate to severe endometriosis on mRNA expression of growth differentiation factor-9 (GDF-9) in the granulosa cells of mature follicles. Methods: Follicular fluid (FF) was obtained from 13 patients with moderate to severe endometriosis and 11 without endometriosis, as a control group, and GDF-9 protein levels in both were assayed by western blotting. mRNA expression by GDF-9 and LH receptor (LHR) in granulosa cells obtained from all patients in the study were investigated by StepOne Real-Time PCR. Results: Although GDF-9 in FF from patients with endometriosis was no different from that of controls, GDF-9 mRNA expression in granulosa cells of patients with endometriosis was statistically significantly lower than for the control group. The number of oocytes and high-quality embryos was positively correlated with GDF-9 mRNA expression in controls but not in patients with endometriosis Moreover, a negative correlation was identified between GDF-9 mRNA expression and serum estrogen and progesterone levels in the control group, whereas no correlation was observed for the endometriosis group. Conclusions: Moderate to severe endometriosis can significantly reduce GDF-9 mRNA expression in the granulosa cells of patients with the disease compared with those without, thus causing poor oocyte maturation and lower embryo quality.2015年10月, Reproductive medicine and biology, 14(4) (4), 179 - 184, 英語, 国内誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2015年10月, 産婦人科の進歩, 67(4) (4), 522 - 522, 日本語卵巣チョコレート嚢胞の術後再発
- Endometrial cancer is the most prevalent gynecologic cancer in the Western world, and the number of advanced chemotherapy-resistant cancers is increasing with the absolute increase in patients. The development of resistance to chemotherapeutic drugs by cancer cells represents a major challenge in the clinical cure of advanced and metastatic cancers. CD24 has been reported to be a marker for a poor prognosis in several tumors, and we herein examined the functions of CD24 in human endometrioid adenocarcinoma cell lines and evaluated how it contributes to cancer drug resistance. We demonstrated that CD24 was responsible for the recruitment of phosphorylated Met to the lipid raft domain of the cell membrane, resulting in amplification of the Met signaling cascade, ultimately leading endometrial cancer cells to express higher levels of ATP-binding cassette (ABC) transporters. Our findings suggest that CD24-mediated amplification of the Met cascade may contribute to the drug resistance of endometrial cancer.2015年10月, Molecular cancer therapeutics, 14(10) (10), 2353 - 63, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本臨床細胞学会, 2015年10月, 日本臨床細胞学会雑誌, 54(Suppl.2) (Suppl.2), 565 - 565, 日本語卵巣ブレンナー腫瘍を細胞診で診断し得た1例
- BACKGROUND: The ovarian cellular fibrous tumor with mitotic figure >4 per 10 high power field without moderate to severe atypia is defined as mitotically active cellular fibroma according to the 2014 World Health Organization classification. As this category is new and rare now, we described here a case of MACF and reviewed the literature. CASE: We present a case of mitotically active cellular fibroma of the ovary with 10-year history that was treated with laparoscopic surgery. METHODS: We reviewed the relevant literature using PubMed search system and analyzed the previous cases. RESULTS: To date, only 5 cases of mitotically active cellular fibroma have been reported. Our patient is the first case of mitotically active cellular fibroma of the ovary treated with laparoscopic surgery. CONCLUSION: MACF of the ovary is a newly defined category and few cases have been reported, while prognostic factors have also not yet been fully characterized. Long-term clinical follow-up is necessary.2015年10月, Journal of ovarian research, 8, 65 - 65, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Although we previously demonstrated that paclitaxel and carboplatin chemotherapy (TCchem) is associated with vascular toxicities, the underlying mechanisms remain unclear. Cisplatin is known to inhibit PPARα following microvascular damage to the kidneys. The primary aim of this study was to evaluate whether TCchem induces vascular endothelial dysfunction via systemic PPARα deficiency. In addition, human umbilical vein endothelial cells (HUVECs) were used to elucidate the mechanisms responsible for TCchem-induced vascular toxicities. METHODS: This study enrolled 45 gynecological cancer patients with normal lipid profiles who underwent surgical treatment followed by TCchem. The elevated triglyceride (TG) group included patients (n = 19) who exhibited hypertriglyceridemia during TCchem, and the stable TG group (n = 15) included patients with a normal TG level. Eleven patients exhibiting hypertriglyceridemia during TCchem were administered bezafibrate (fibrate group). Endothelial dysfunction was evaluated based on flow-mediated dilation (FMD) values and serum pentraxin-3 levels measured before TCchem and immediately after the final TCchem. HUVECs were used to elucidate the biological mechanisms underlying the endothelial dysfunction induced by TCchem. RESULTS: The administration of TCchem induced hypertriglyceridemia in 66 percent of the participants, and bezafibrate reduced the serum TG levels. Meanwhile, the decrease in flow-mediated dilatation (%FMD) induced by TCchem improved following treatment with bezafibrate. The serum pentraxin-3 level increased rapidly after TCchem and decreased following bezafibrate treatment. An in vitro examination demonstrated TCchem attenuated nitric oxide production and PPARα activity in HUVECs, which was partially improved by treatment with bezafibrate. CONCLUSION: Bezafibrate prevents endothelial dysfunction induced by TCchem via TG-dependent and TG-independent mechanisms.2015年08月, International journal of clinical oncology, 20(4) (4), 829 - 38, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Administration of the human papillomavirus (HPV) vaccine decreased dramatically in Japan after extensive news of adverse vaccine events and suspension of the governmental recommendation for the vaccine. In this study, we investigated the knowledge and acceptance of vaccinated adolescents concerning cervical cancer, cancer screening and the HPV vaccine. Furthermore, we analyzed whether and by how much the news affected acceptance of the vaccination. METHODS: This study was conducted as a part of Osaka Clinical resEArch of HPV vacciNe (OCEAN) study. A questionnaire was distributed to 2,777 study registrants. RESULTS: The response rate was 38%. The recognition rate of the news of the vaccine's adverse events was 80%; it was 68% for awareness of the government's announcement of the suspension of its recommendation for the vaccine. Among those who had a chance to hear or see the negative news during their vaccination period, 46 (60%) continued vaccination while knowing of the news, 22 (29%) discontinued vaccination, and 9 (11%) continued vaccination without an awareness of the news. Reports of the vaccine's adverse events were the main reason for not continuing the vaccination series. Those who consulted doctors after hearing the adverse news were significantly more likely to continue their vaccinations than those who did not. CONCLUSIONS: Our results should help in understanding the need for a strong promotion of vaccine usage and cancer screening after future retraction of the recommendation suspension. This may apply to other countries with an unsatisfactory rate of HPV vaccination due to fears of adverse vaccine events.2015年06月, International journal of clinical oncology, 20(3) (3), 549 - 55, 英語, 国内誌研究論文（学術雑誌）
- The pathogenesis of endometriosis, a chronic painful gynecological disease characterized by the presence of endometrial tissue located outside of the uterus and often adhering to the peritoneum, is known to be estrogen dependent. However, the precise pathophysiology of endometriosis remains elusive. Recent studies indicate that the epithelial-to-mesenchymal transition (EMT) of human endometrial cells is important for the progression of endometriosis, and another previous study has implicated hepatocyte growth factor (HGF) in endometriosis progression. The aim of the present study was to examine the role of estradiol in the regulation of HGF production and progression of peritoneal endometriosis, focusing on the interactions between the peritoneum and endometriotic cells. Consequently, estradiol was found to promote the proliferation, invasion, and migration of immortalized human endometrial epithelial cells (hEECs) via HGF upregulation, and the estradiol-induced direct binding of estrogen receptor-α to the HGF promoter was confirmed on a chromatin immunoprecipitation (ChIP) assay. Estradiol also induced the EMT in hEECs by promoting HGF production. Furthermore, human mesothelial cells underwent the mesothelial-to-mesenchymal transition (MMT) during culture with estradiol-stimulated hEEC conditioned medium. Importantly, estradiol itself did not induce the MMT, and the estradiol-stimulated hEEC-conditioned medium in the presence of HGF antibodies reversed the MMT process. These results, which were obtained using immortalized hEECs, indicate that estradiol-induced HGF production may play a crucial role in the peritoneal implantation of human endometriotic cells by exerting proliferative and invasive effects via the EMT in hEECs and promoting the MMT in mesothelial cells.2015年06月, American journal of physiology. Endocrinology and metabolism, 308(11) (11), E950-9, 英語, 国際誌研究論文（学術雑誌）
- 2015年06月, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 25(5) (5), 879 - 883, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本臨床細胞学会, 2015年04月, 日本臨床細胞学会雑誌, 54(Suppl.1) (Suppl.1), 311 - 311, 日本語卵巣粘液性境界悪性腫瘍(内頸部様)の1例
- OBJECTIVE: The aim of this study was to estimate the incidence, etiology, and outcomes of genitofemoral neuropathy after pelvic lymphadenectomy (PLD) for uterine corpus cancer. MATERIALS AND METHODS: The medical records of women who underwent PLD for uterine corpus cancer between June 2001 and June 2013 were reviewed. Information regarding neuropathy was directly reported by each subject. RESULTS: Thirty-two of 300 patients undergoing PLD during the defined period experienced postoperative neuropathy due to genitofemoral nerve injury, for an incidence of 10.7%. The patients treated with PLD with para-aortic lymphadenectomy (PALD) exhibited a lower rate of genitofemoral neuropathy than those treated without PALD (4.3% vs 13.5%, P = 0.01). The laparoscopy group displayed a higher rate of genitofemoral neuropathy than the laparotomy group (19.1% vs 9.1%, P = 0.04). A total of 81.3% of the patients experienced a full recovery, with a medium time to resolution of 6 months (3-12 months). The administration of adjuvant chemotherapy, including paclitaxel, did not extend the time to recovery. CONCLUSIONS: Neuropathy resulting from genitofemoral nerve injury is not infrequent; however, most of the patients recover completely. In this study, the use of laparoscopic procedures increased the incidence of genitofemoral neuropathy, whereas that of PALD did not.2015年03月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 25(3) (3), 533 - 6, 英語, 国際誌研究論文（学術雑誌）
- Gastric-type adenocarcinoma (GAS) of the uterine cervix is a recently defined subtype of mucinous adenocarcinoma. GAS is proposed to include minimal deviation adenocarcinoma (MDA) as a very well-differentiated form and has been suggested to arise from lobular endocervical glandular hyperplasia (LEGH). We report the magnetic resonance imaging (MRI) findings of a GAS associated with LEGH. On MRI, the LEGH component was detected as multiple cystic lesions arranged in a "cosmos pattern", while the GAS was depicted as a predominantly solid lesion containing obvious adenocarcinoma and MDA components, which appeared as mass-like and infiltrative components, respectively. The GAS exhibited tiny cysts on three-dimensional T2-weighted images, high intensity on diffusion-weighted images mostly due to T2 shine-through effect according to apparent diffusion coefficient (ADC) map, and reticular enhancement on dynamic contrast-enhanced MRI, which reflected numerous dilated glandular structures of the tumor. Low ADC was only observed at the deepest invasion front of the obvious adenocarcinoma component. Our case suggests that the MRI features of GAS vary depending on the tumor's histological components, and it is important to be aware of these imaging features when evaluating LEGH on MRI.2015年03月, Abdominal imaging, 40(3) (3), 459 - 65, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本産科婦人科学会, 2015年02月, 日本産科婦人科学会雑誌, 67(2) (2), 499 - 499, 日本語
- 2015年02月, CANCER BIOLOGY & THERAPY, 16(2) (2), 325 - 335, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 巨大卵巣腫瘍は総重量が10～20kg以上，または体重比20%以上と定義されているが，巨大卵巣腫瘍が茎捻転をするのは2.9%とまれである．今回われわれは，腫瘍径34cmで腫瘍内容液が13kgの卵巣嚢腫の茎捻転症例を経験したので報告する．症例は26歳の未経妊でBMIは43kg/m2であった．既往歴に特記事項はなかった．3日前より認める下腹部痛を主訴に前医を受診し巨大腫瘍を指摘され，精査加療目的に当科紹介となった．当科初診時，呼吸困難を自覚しており，季肋部に達する巨大腫瘤を触知し，左下腹部に軽度のブルンベルグサインを認めた．超音波断層法で長径32cmの単房性嚢胞性腫瘤を認め，急性腹症，巨大卵巣嚢腫の診断にて緊急入院となった．血中腫瘍マーカーはCA125のみが41.9U/mlと軽度高値であった．造影CT検査所見は34×31×27cmの腫瘤であり，嚢胞壁に造影効果はみられないことより左卵巣腫瘍の茎捻転と診断した．そのため，入院同日に緊急腹腔鏡下左付属器摘出術を施行した．嚢腫は紫藍色であり，左付属器は反時計回りに540度捻転していた．腫瘍内容液量は13590ml であった．術中腹水細胞診は陰性で術中迅速組織診は漿液性腺腫であり，最終病理組織診断結果も同様であった．術後経過は良好で術後5日目に軽快退院となった．〔産婦の進歩67（2）：95-100，2015（平成27年5月）〕近畿産科婦人科学会, 2015年, 産婦人科の進歩, 67(2) (2), 95 - 100, 日本語
- 近畿産科婦人科学会, 2015年, 産婦人科の進歩, 67(3) (3), 340 - 343, 日本語
- 子宮腺筋症は卵巣子宮内膜症からの癌化と同様，類内膜腺癌や漿液性腺癌，明細胞腺癌などの前駆体となる可能性があり，1987年にRollyがケースレポートを報告して以来，今まで44例報告されている．しかし，その病態やメカニズムについては未知である．今回，われわれは子宮腺筋症の癌化と考えられた8症例を後方視的に検討し，臨床的特徴および診断における問題点について検討した．2005年1月から2014年9月までに大阪医科大学附属病院で施行した子宮体癌症例497例を対象とした．子宮腺筋症の癌化と診断したのは8症例（1.6%）であった．年齢の中央値は53歳であり，通常の子宮体癌症例（中央値59歳）と差異はなかった（p=0.42）．主訴は8例中6例が不正出血であった．組織型は全例が類内膜腺癌であり，進行期はIA期：6例，IB期：1例，IIIc期：1例であった．筋層浸潤は1/2未満が7例，1/2以上が1例であり，全子宮体癌症例と同等（p=0.10）であった．術前内膜組織診の正診率は75%であり，2例においては分化度のup gradeを認めた．術中迅速病理診断を行った7症例における組織像の正診率は100%であった．筋層浸潤に関しては術前MRIにおける正診率は88%で1例が過大評価であった．また術中迅速病理診断を行った7症例における筋層浸潤の正診率は100%であった．8症例全例が無病生存中である（観察期間：14～92カ月）．子宮腺筋症由来の子宮体癌はまれであり，今回の検討では通常の内膜癌と比較して臨床的特徴はみられなかった．腺筋症の癌化では内膜病変を認めないこともあり術前診断が困難な場合がある．また今回の8症例は筋層浸潤の有無にかかわらず全例無病生存であり予後は良かったが，今後は子宮深部に腺筋症の癌化を認めた場合に，通常の内膜癌と同等に取り扱うべきかどうかは症例を集積したうえでの検討が望まれる．〔産婦の進歩67（3）：247-253，2015（平成27年8月）〕近畿産科婦人科学会, 2015年, 産婦人科の進歩, 67(3) (3), 247 - 253, 日本語
- We present the computed tomography (CT) and magnetic resonance (MR) imaging findings of a 71-year-old woman with a cardiac extension of intravenous leiomyoma (IVL) that arose from the uterus, extended to the inferior vena cava (IVC), and reached the right ventricle through the right ovarian vein. Radiologic-pathologic correlation showed that the intravascular cord-like mass originating from the IVC and extending to the right ventricle was composed of degenerated smooth muscle cells with a number of large vessels that were regarded as arteries; moreover, the arteries within the cord-like mass appeared to be looping internally. Given the disappearance of the right ovarian venous wall around the IVL pathologically, extracting the tumor from the ovarian vein during an operation is considered to be impossible retrospectively. Also it was difficult to identify even the intravenous extension of the uterine leiomyoma histopathologically. Therefore, contrast-enhanced CT, in particular arterial phase imaging, provided important information that revealed the mass, range, and path of the lesion, ensuring that an appropriate operative plan could be drawn up and the tumor completely excised.2015年, Case reports in obstetrics and gynecology, 2015, 576743 - 576743, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- A 48-year-old woman was referred to the cardiology department due to a large mobile mass in the right ventricle. The patient had undergone radical hysterectomy and bilateral salpingo-oophorectomy for a uterine squamous cell carcinoma approximately 3.5 years before. In order to protect the patient from circulatory collapse, the intracardiac mass was resected surgically. A diagnosis of cardiac metastasis of the uterine cervical squamous cell carcinoma was confirmed histologically. Herein we discuss the possible therapeutic approach to and prognosis of this rare condition by reviewing 24 papers on intracardiac uterine cancer metastasis published in the past 10 years.2014年12月, Journal of cardiology cases, 10(6) (6), 221 - 225, 英語, 国内誌
. 研究論文（学術雑誌） - 2014年11月, JOURNAL OF ENDOCRINOLOGY, 223(2) (2), 203 - 216, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVE: Menopause is defined as the permanent cessation of menses. Although previous studies demonstrated a slight production of androgens and estrogens by postmenopausal ovaries, the impact of hormone production on lipid metabolism is still uncertain. The aim of this study was to evaluate whether the postmenopausal ovary is hormonally active and whether hormone status contributes to lipid metabolism. METHODS: This was a prospective study of 87 women who were treated for gynecological diseases (29% had cervical cancer, 49% had endometrial cancer, 7% had fibroid tumors, and 15% had cervical intraepithelial neoplasia). They were categorized as early postmenopausal (n = 40; mean [SD], 56.8 [3.8] y) or late postmenopausal (n = 47; mean [SD], 66.6 [5.7] y) women. Serum specimens were collected from the peripheral and ovarian veins of participants undergoing bilateral oophorectomy. Sex steroid hormone levels and lipid profiles were determined. RESULTS: Statistically significant differences in estradiol (E2) and testosterone were seen between the ovarian samples and the peripheral samples in all groups. E2 and estrone obtained from ovarian venous samples gradually decreased with age in postmenopausal women. There was a significant correlation between ovarian E2 and high-density lipoprotein cholesterol levels and the low-density lipoprotein-to-high-density lipoprotein ratio. However, there was no correlation between peripheral E2 levels and any of the lipid parameters examined. CONCLUSIONS: Although this study investigates women with gynecological diseases, the postmenopausal ovary is hormonally active, and the E2 produced by postmenopausal ovaries may therefore contribute to the maintenance of lipid metabolism.2014年10月, Menopause (New York, N.Y.), 21(10) (10), 1129 - 35, 英語, 国際誌研究論文（学術雑誌）
- 「産婦人科の進歩」編集室, 2014年10月, 産婦人科の進歩, 66(4) (4), 490 - 490, 日本語体外受精治療における化学的流産周期の検討
- OBJECTIVE: Type 1 endometrial cancer (EC) is typically sex hormone sensitive; however, most women diagnosed with EC have already gone through menopause. Several studies have reported that the postmenopausal ovary is hormonally active, and estradiol (E2) production from the ovaries persists for as much as 10 years beyond menopause. The aim of this study was to evaluate whether sex steroid production from the ovaries contributes to the pathogenesis of type 1 EC. MATERIALS AND METHODS: This was a prospective study of 53 women treated for EC (28 cases of type 1 disease and 25 cases of type 2 disease). Serum specimens were collected from the peripheral and ovarian veins of participants undergoing bilateral oophorectomy. The sex steroid hormone levels and hormonal milieu on cervical cytology were evaluated as maturation value (MV). In addition, the degree of stromal hyperplasia of the ovary was evaluated histologically. RESULTS: Although the E2 levels of the peripheral veins did not show any significant differences [8.2 (5.1-12.4) vs 7.4 (5.1-11.7) pg/mL, respectively; P < 0.05], the patients with type 1 EC had a higher E2 level in the ovarian vein than those with type 2 EC [25 (13.8-42.5) vs 15 (10.0-23.0) pg/mL, respectively; P < 0.05]. There were also no significant differences in the rate of moderate to marked hyperplasia of the ovarian stroma between the groups; however, the thickness of the ovarian cortex demonstrated a correlation with the ovarian E2 level. In addition, the MV displayed a strong correlation with the ovarian E2 level, but not the peripheral E2 level. CONCLUSIONS: The postmenopausal ovary is hormonally active, especially in patients with type 1 EC. The degree of ovarian stromal hyperplasia may (at least in part) contribute to the progression of type 1 EC, and MV may predict the level of E2 production from the ovaries in postmenopausal women.2014年10月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 24(8) (8), 1455 - 60, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature of this process is the downregulation of the E-cadherin expression, which is primarily controlled by Snail-related zinc-finger transcription factors. The aim of this study was to evaluate the prognostic impact of the expression of EMT-related proteins (E-cadherin and Snail) in patients with ovarian cancer. METHODS: An immunohistochemical analysis was conducted using tissue microarray samples of 174 primary tumors and 34 metastases of ovarian carcinoma, and the relationships between the protein expression, clinicopathological features and outcomes were investigated. RESULTS: A reduced E-cadherin expression was observed in 36.8% of the primary tumors and 30.4%, 35.7%, 37.7% and 52.7% of the stage I, II, III and IV tumors, respectively. The nuclear expression of Snail was positive in 33.9% of the primary tumors. The rate of an EMT-positive status, as represented by both a reduced E-cadherin expression and a nuclear expression of Snail, was significantly higher in the patients with peritoneal dissemination than in those without (p < 0.05). The EMT status was significantly associated with both the progression-free survival and overall survival (p <0.01). A multivariate analysis showed an EMT-positive status to be a significant predictor of both the progression-free survival (p < 0.05) and overall survival (P < 0.01). CONCLUSIONS: These data indicate that the EMT status is significantly associated with peritoneal metastasis and both the progression-free survival and overall survival in patients with ovarian cancer. Therefore, clarifying and controlling EMT signaling is a promising approach to molecular targeted therapy for ovarian cancer.2014年07月, Journal of ovarian research, 7, 76 - 76, 英語, 国際誌研究論文（学術雑誌）
- AIM: The aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa. MATERIAL AND METHODS: We retrospectively reviewed the medical records of all patients diagnosed with placenta previa admitted to our hospital. Two consecutive periods were compared. During period B, 59 patients underwent the local injection of a vasopressin solution (4 U in 20 mL of saline) into the placental implantation site after placental delivery. During period A, 50 patients underwent cesarean section without vasopressin injection, and were analyzed as a control group. The estimated blood loss was recorded, as were the complications during surgery. In addition, the expression of the vasopressin V1α receptor in uterine smooth muscle was evaluated by immunohistochemistry. RESULTS: The mean estimated blood loss was significantly lower in the vasopressin group than in the control group. There were no statistically significant differences with surgical complications. The vasopressin V1α receptor was highly expressed in smooth muscle cells in the lower segment of the uterine body, whereas the immunoreactivity for the oxytocin receptor was faint in the lower segment. CONCLUSION: The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity.2014年05月, The journal of obstetrics and gynaecology research, 40(5) (5), 1249 - 56, 英語, 国際誌研究論文（学術雑誌）
- AIM: To examine the associations between the pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) with pregnancy outcomes in Japanese women. METHODS: The medical records of 1883 Japanese women who delivered singleton infants from January 2010 to January 2013 at Osaka-Minami Medical Center were retrospectively reviewed. We use the BMI classification which the World Health Organization defined for Asian populations and the GWG classified based on the current 2009 Institute of Medicine (IOM) recommendations. The odds ratio (OR) of each of the groups for the different pregnancy outcomes were compared to the recommended group using a logistic regression analysis adjusted by age, gestational weeks, parity, weight gain, mode of delivery, pregnancy induced hypertension (PIH) and gestational diabetes mellitus. RESULTS: Women who were obese (BMI, ≥25 kg/m(2) ) and overweight (BMI, 23-24.9 kg/m(2) ) had a higher rate of developing PIH (adjusted OR, 6.68 and 3.21 [95% confidence interval [CI], 3.31-13.3 and 1.29-7.24]). In contrast, GWG exhibited a correlation with the weight of the infant. The inadequate GWG group had a higher rate of small-for-gestational age (SGA) infants (adjusted OR, 1.72 [95% CI, 1.22-2.46]). The rate of emergency cesarean section was not significantly different between the groups. CONCLUSION: A pre-pregnancy BMI less than 23 kg/m(2) is desirable to prevent Japanese women from developing PIH. GWG within the IOM recommendations also reduced the risk of PIH and SGA.2014年05月, The journal of obstetrics and gynaecology research, 40(5) (5), 1296 - 303, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Gemcitabine (2', 2' -difluorodeoxycytidine) is one of many nonplatinum drugs that exhibit activity in recurrent, platinum-resistant ovarian cancer. However, the molecular mechanisms by which Gemcitabine treatment inhibits the proliferation of platinum-resistant ovarian cancer cells still remain unclear. We investigated whether Gemcitabine increases the efficacy of Cisplatin in platinum-resistant ovarian cancer models in vitro and in vivo. METHODS: We used Cisplatin-resistant Caov-3 cells, A2780CP cells and Cisplatin-sensitive A2780 cells to examine the sensitivity of the cell viability of Cisplatin and Gemcitabine using a 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay and the sensitivity of the invasive activity of Cisplatin and Gemcitabine using an invasion assay with Matrigel. We examined the Akt kinase activity and matrix metalloproteinase 9 (MMP9) expression following Cisplatin and Gemcitabine treatment using a Western blot analysis and the mRNA expression of vascular endothelial growth factor (VEGF) using semi-quantitative RT-PCR. Moreover, we evaluated the effects of Cisplatin and Gemcitabine on the intra-abdominal dissemination of ovarian cancer in vivo. RESULTS: Gemcitabine significantly inhibited Cisplatin-induced Akt activation in the Caov-3 and A2780CP cells, but not in the A2780 cells. In the presence of Gemcitabine, Cisplatin-induced growth inhibition and apoptosis were significantly enhanced in the Caov-3 and A2780CP cells. Co-treatment with Cisplatin and Gemcitabine almost completely inhibited invasion of both types of cells through the Matrigel; however, neither Cisplatin nor Gemcitabine alone inhibited the invasion of both types of cells. Gemcitabine inhibited not only the Cisplatin-induced activation of Akt, but also the MMP9 and mRNA expression of VEGF. Moreover, treatment with Gemcitabine increased the efficacy of Cisplatin-induced growth inhibition of the intra-abdominal dissemination and production of ascites in the athymic nude mice inoculated with Caov-3 cells. CONCLUSIONS: We herein demonstrated that Gemcitabine inhibits the Akt kinase activity and angiogenetic activity following treatment with Cisplatin in platinum-resistant ovarian cancer cells. These results provide a rationale for using Gemcitabine in clinical regimens containing molecular targeting agents against platinum-resistant ovarian cancers.2014年04月, Journal of ovarian research, 7, 38 - 38, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: We performed TaqMan genotyping assays of anti-Mullerian hormone (AMH) and anti-Mullerian hormone receptor type II (AMHRII) single nucleotide polymorphisms (SNPs) in order to investigate how their frequency and distribution affect infertility treatment outcome. METHODS: Eighty Japanese women (advanced age: n = 51, endometriosis: n = 18, male infertility as a control: n = 11) who undertook ART were included in the study, and all couples underwent a full infertility investigation protocol. In order to investigate the natural distribution of SNPs, a naturally pregnant group of 28 subjects was recruited from among women who conceived naturally and subsequently delivered in our department. Genomic DNA was extracted from peripheral blood and genotyping was conducted by TaqMan genotyping assay. The relationship of AMH and AMHRII SNPs and treatment outcome in infertile women. Comparison of allele and genotype frequencies of infertile patients with naturally pregnant women. RESULTS: AMHRII -482 A>G homozygote mutation was complicated with ISV 5-6 C>T homozygote mutation and showed a significantly lower oocyte retrieval rate compared with a wild type. Two of 3 cases of AMHRII -482 A>G homozygote mutation were poor responders, and the distribution and frequency of each allele of naturally pregnant women showed no statistical difference compared with infertile women. CONCLUSIONS: This study revealed the possible involvement of AMHRII -482 A>G polymorphism on the malfunction of follicular development in Japanese women.2014年02月, Journal of assisted reproduction and genetics, 31(2) (2), 163 - 8, 英語, 国際誌研究論文（学術雑誌）
- AIM: This is the first report to determine the feasibility and safety of total laparoscopic modified radical hysterectomy (TLMRH) in the treatment of presumed stage I endometrial cancer. METHODS: This was a retrospective study of 132 consecutive patients who underwent surgery for early endometrial cancer. Thirty-nine patients underwent TLMRH and bilateral salpingo-oophorectomy (BSO), and 93 had a total abdominal extrafascial hysterectomy and BSO. Lymphadenectomy was performed in 87 patients. The groups were compared for epidemiological and clinical characteristics, surgical outcomes, hospital stay, lymph nodes harvested, and intraoperative and postoperative complications. RESULTS: The patients in the TLMRH group had less blood loss (42.9 ± 76.3 vs 236.8 ± 186.6 mL, P < 0.0001), a similar number of lymph nodes removed (32.3 ± 13.1 vs 28.0 ± 11.9, P = 0.15), less need for analgesia and a shorter hospital stay (9.3 ± 2.5 vs 14.6 ± 12.6 days, P = 0.009) but longer operations (321.1 ± 65.9 vs 262.6 ± 75.0 min, P < 0.0001) than those treated by laparotomy. In our study, we had no conversions from laparoscopy to laparotomy. No major complications occurred in the TLMRH group. The patients who underwent TLMRH had less intense postoperative pain than patients treated by laparotomy. The median length of vaginal cuff removed was 12.0 ± 4.1 mm in the TLMRH group, and was 5.6 ± 6.6 mm in the laparotomy group (P < 0.0001). No patients demonstrated recurrence in either of the groups after a median follow-up of 48.5 months (range, 1-84). CONCLUSION: TLMRH is a safe and reliable alternative to open surgery in the management of early endometrial carcinoma, with a significantly reduced hospital stay and complications.2014年02月, The journal of obstetrics and gynaecology research, 40(2) (2), 570 - 5, 英語, 国際誌研究論文（学術雑誌）
- STUDY OBJECTIVE: To evaluate how endometriotic cystectomy and vaporization affect ovarian reserve after conservative surgery. DESIGN: Prospective study (Canadian Task Force classification II-1). SETTING: Hokusetsu General Hospital. PATIENTS: Ninety-nine women who underwent conservative surgery to treat endometriotic cysts from June 2011 to July 2013. INTERVENTIONS: Vaporization with bipolar current was performed in nulligravid women, and cystectomy in those who had a child. In women with endometriotic cysts, bilateral cystectomy was performed in 28, bilateral vaporization in 15, unilateral cystectomy in 40, and unilateral vaporization in 16. In all patients, preoperative and postoperative serum anti-müllerian hormone (AMH) and follicle-stimulating hormone (FSH) concentrations at the early proliferative phase were assayed, and the change in concentrations was evaluated for each operation. MEASUREMENT AND MAIN RESULTS: In the bilateral cystectomy group, the mean (SD) postoperative FSH concentration (19.3 [21.8] IU/mL) was statistically higher than the preoperative concentration (9.0 [6.2] IU/mL) (p < .01). AMH significantly declined after all operations to treat endometriotic cysts, and the rate of decline in the AMH concentration was >50% compared with preoperative concentrations. CONCLUSION: Whether endometriotic cysts are unilateral or bilateral, both cystectomy and vaporization using bipolar current can lower ovarian reserve. Therefore, it is necessary to develop more effective surgical procedures to prevent ovarian damage.2014年, Journal of minimally invasive gynecology, 21(5) (5), 804 - 10, 英語, 国際誌研究論文（学術雑誌）
- Although endometriosis is suspected to be a cause of premature ovarian insufficiency (POI), the mechanism(s) underlying this process have not been elucidated. Recently, androgens were shown to promote oocyte maturation and to play a role in folliculogenesis. In addition, several reports have documented low testosterone levels in the follicular fluid obtained from endometriosis patients. We therefore examined whether the low levels of serum testosterone are associated with the apoptosis of granulosa cells in follicles obtained from endometriosis patients. Serum samples were collected from 46 patients with endometriosis and from 62 patients without endometriosis who received assisted reproductive therapy. Specimens of the ovaries obtained from 10 patients with endometrioma were collected using laparoscopy. The mean serum testosterone concentration in the patients with endometriosis was significantly lower than that observed in the patients without endometriosis. Furthermore, high expression of a pro-apoptotic Bcl-2 member, BimEL, in the follicles was found to be associated with a low serum testosterone level. We clarified the underlying mechanisms using a basic approach employing human immortalized granulosa cells derived from a primary human granulosa cell tumor, the COV434 cell line. The in vitro examination demonstrated that testosterone inhibited apoptosis induced by sex steroids depletion via the PI3K/Akt-FoxO3a pathway in the COV434 cells. In conclusion, we elucidated the mechanism underlying the anti-apoptotic effects of testosterone on granulosa cells, and found that a low-testosterone status is a potentially important step in the development of premature ovarian insufficiency in patients with endometriosis.2014年, PloS one, 9(12) (12), e115618, 英語, 国際誌研究論文（学術雑誌）
- 子宮内膜症の発生頻度は性成熟女性の約10%とされる．一方，子宮内膜症にはさまざまな合併症（骨盤痛や不妊症，付属器腫瘍など）が起こるが，近年子宮内膜症性嚢胞から約0.7%に卵巣癌が発生することが知られている．今回われわれは，経過観察中に臨床的，病理組織学的に子宮内膜症性嚢胞から発生したと考えられた卵巣癌4症例を経験したので，その臨床経過や特徴を報告する．症例は38歳から48歳（平均値43.3歳）．2例は子宮内膜症と診断されてから10年以上の経過観察期間があった．1例は診断から約1カ月の間に充実性部分の出現を認めた．腫瘍径は8cmから20cmで，術前の腫瘍マーカーはCA125 56.9～313 U/ml，CA19-9 99～174 U/mlであった．全例画像所見から悪性を指摘された．MRI画像ではT2強調画像で低信号を呈する充実部分の出現と同部位の造影効果の増強を認め，内容液はT1強調画像で等～低信号，T2 強調画像で高信号を呈していた．全例で卵巣癌根治術を施行，術後病理組織の結果は類内膜腺癌2例，明細胞腺癌2例であった．進行期は1A期，1C期，2C期，3C期であり，1A期を除いた症例で術後補助療法としてTC療法を施行した．現在平均50カ月経過観察しているが，全例再発徴候なく経過良好である．今回経験した4症例から，子宮内膜症性卵巣嚢胞の癌化におけるMRI検査での腫瘍内容液の性状の変化，壁在結節の存在が重要な所見であった．また1カ月という短期間に充実部が出現した症例や1年ごとの画像検査を施行していても進行卵巣癌で発見される症例も存在することから，内膜症性卵巣嚢胞にも急な変化を示すものがあることを念頭に置いた管理が必要であると考えられた．〔産婦の進歩66（2）:155-162，2014 （平成26年5月）〕近畿産科婦人科学会, 2014年, 産婦人科の進歩, 66(2) (2), 155 - 162, 日本語
- OBJECTIVES: To introduce a safe and reliable method for the management of peripheral vessels around the uterine artery during abdominal radical hysterectomy or abdominal radical trachelectomy. STUDY DESIGN: From 2007 to 2011, 102 patients with invasive cervical cancer underwent an abdominal radical hysterectomy. In 48 operations in 2007-2009, we performed the conventional radical hysterectomy, in which we ligated and cut the uterine arteries at their origin, and we divided the anterior leaf of the vesico-uterine ligament by blindly inserting scissors into the ureteral tunnel, pushing the ureter laterally from the cervix. In 54 operations in 2009-2011, we pulled up the origin and the bifurcation of the uterine artery using vessel tape, skeletonized the uterine artery and directly divided the superficial uterine vein, superior vesical vein and ureteric branch of the uterine artery. We also performed four radical trachelectomies using the two point pull-up method. We investigated whether this method was useful for the management of peripheral vessels around the uterine artery. RESULTS: The mean total blood loss in the two point pull-up method group (485 ± 270 ml) was significantly lower than that in the conventional surgery group (686 ± 554 ml) (p<0.05). The mean length of the operation in the two point pull-up method group (481 ± 53 min) was not significantly different from the conventional surgery group (497 ± 74 min) (p=0.111). The mean number of dissected lymph nodes in the two point pull-up method group (37.2 ± 11.6) was not significantly different from that in the conventional method group (34.4 ± 10.2) (p=0.096). The overall survival and progression-free survival were also not substantially different between the two groups. In the radical trachelectomy, the mean blood loss was 377.5 ± 185.6 ml and the mean duration of surgery was 520.0 ± 48.5 min using the two point pull-up method. We were able to preserve both uterine arteries without accidental injury or disruptive bleeding. All four patients were menstruating normally as of the last examination. CONCLUSIONS: The two point pull-up method enabled us to reduce intraoperative blood loss without increasing other complications during abdominal radical hysterectomy or abdominal radical trachelectomy.2013年10月, European journal of obstetrics, gynecology, and reproductive biology, 170(2) (2), 544 - 9, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Examination of the mitochondrial mRNA expression in granulosa cells from an unspecified population of infertile patients to evaluate whether recombinant follicle stimulating hormone (recFSH) is more effective in producing higher quality embryo rates compared with human menopausal gonadotropin (hMG). METHOD: Thirty-nine patients who underwent the in vitro fertilization and embryo transfer program were retrospectively examined. Patients were administered recFSH (n = 18) or hMG (n = 20) in a long protocol where GnRH agonist was used. Granulosa cells were obtained during oocyte retrieval and examined for mitochondria mRNA expression ratio against GAPDH. Expressions of mitochondria mRNA were evaluated by real-time PCR analysis. RESULTS: The high-quality embryo rate in the hMG cycle was higher than in the recFSH cycle, and the total dose of hMG showed a positive correlation with the expression level of mitochondrial genes in granulosa cells. Moreover, mitochondria mRNA expression was higher in the hMG cycle than in the recFSH cycle. CONCLUSIONS: Compared with recFSH, hMG induces a higher mitochondrial gene expression ratio in granulosa cells at the time of oocyte retrieval and, therefore, may lead to higher quality embryo rates.2013年07月, Reproductive medicine and biology, 12(3) (3), 99 - 104, 英語, 国内誌研究論文（学術雑誌）
- AIM: The aim of this study was to evaluate the effect of our novel technique on the prevention of postoperative ileus in patients undergoing systematic para-aortic lymphadenectomy (PALN). MATERIAL AND METHODS: PALN was performed in 135 gynecological cancer patients (67 with ovarian cancer, 58 with endometrial cancer, 8 with serous surface papillary adenocarcinoma (SSPC) and 2 with fallopian tube cancer) between 2006 and 2011. To prevent postoperative ileus, we performed our novel technique wherein the small bowel and colon are released from pressure and soaked in 2 L of physiological saline for 1 min every 20 min during the lymphadenectomy. We indicated our novel PALN technique and retrospectively analyzed the outcomes of the surgical procedure in terms of the surgical data, and postoperative incidence of gastrointestinal dysfunction in patients with gynecological malignancies. RESULTS: The mean blood loss was 641.2 ± 800.3 mL in the PALN group and 313.9 ± 278.9 mL in the pelvic lymphadenectomy (PLN) without PALN group (P < 0.0001). There was no difference in the first passage of flatus between the PALN group and the PLN group (1.8 ± 0.7 days vs 1.6 ± 0.7 days). The mean time to tolerance of a regular diet was significantly longer in the PALN group than in the PLN group (P < 0.0001), whereas the incidence of vomiting was similar in both groups. Surprisingly, there were no cases of postoperative ileus in either group. CONCLUSION: Our novel technique is a safe and effective way to prevent the incidence and decrease the severity of postoperative ileus after PALN for gynecological malignancies.2013年04月, The journal of obstetrics and gynaecology research, 39(4) (4), 849 - 54, 英語, 国際誌研究論文（学術雑誌）
- AIM: The purpose of this study was to compare the intraoperative and postoperative parameters among the three approaches used to treat large uterine myomas: laparoscopic assisted vaginal hysterectomy (LAVH), total laparoscopic hysterectomy (TLH) and abdominal hysterectomy, and to evaluate the selection criteria for laparoscopic hysterectomy as determined by magnetic resonance imaging. MATERIAL AND METHODS: The medical records of 155 patients who underwent a hysterectomy between January 2007 and April 2010 were examined. We also compared the indications and outcomes of LAVH and TLH for myomas larger than 7 cm. RESULTS: Patients who underwent LAVH or TLH had a lower average intraoperative blood loss, less intense postoperative pain, and shorter hospital stays than patients in the TAH group, although the length of the operations in the laparoscopic groups were significantly longer. To evaluate the selection criteria for the large sized myomas, we compared the LAVH and TLH groups for the myomas larger than 7 cm. The greatest uterine transverse diameters and the weight of the uteri were not significantly different between the LAVH and TLH groups (94.7 ± 20.8 and 83.1 ± 17.6 mm, 371.6 ± 160.3 and 286.7 ± 158.0 g, respectively). The average intraoperative blood loss in the TLH group was significantly lower than that in the LAVH (121.3 ± 111.2 vs 379.3 ± 222.4 g, P < 0.001). CONCLUSION: Our data suggest that TLH is a better procedure for treating a large uterus no larger than 10 cm in its greatest transverse diameter. The preoperative total length of myoma nodules determined by MRI is a useful preoperative indicator of the uterine weight.2013年04月, The journal of obstetrics and gynaecology research, 39(4) (4), 814 - 9, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Although surgical menopause may increase the risks of osteoporosis, few studies have investigated the influence of chemotherapy and radiation therapy. The aim of this study is to evaluate the effects of treatments for gynecological malignancies on bone mineral density (BMD). METHODS: This study enrolled 35 premenopausal women (15 ovarian cancers (OCs), 9 endometrial cancers (ECs), and 11 cervical cancers (CCs)) who underwent surgical treatment that included bilateral oophorectomy with or without adjuvant platinum-based chemotherapy in OC and EC patients, or concurrent chemo-radiation therapy (CCRT) in CC patients according to the established protocols at the Osaka Medical College Hospital between 2006 and 2008. The BMD of the lumbar spine (L1-L4) was measured by dual-energy X-ray absorptiometry, and urine cross-linked telopeptides of type I collagen (NTx) and bone alkaline phosphatase (BAP) were assessed for evaluation of bone resorption and bone formation respectively. These assessments were performed at baseline and 12 months after treatment. RESULTS: Although the serum BAP was significantly increased only in the CC group, a rapid increase in the bone resorption marker urinary NTx was observed in all groups. The BMD, 12 months after CCRT was significantly decreased in the CC group at 91.9±5.9% (P<0.05 in comparison to the baseline). CONCLUSION: This research suggests that anticancer therapies for premenopausal women with gynecological malignancies increase bone resorption and may reduce BMD, particularly in CC patients who have received CCRT. Therefore, gynecologic cancer survivors should be educated about these potential risks and complications.2013年03月, Endocrine connections, 2(1) (1), 11 - 7, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature of this process is the downregulation of E-cadherin expression, which is mainly controlled by Snail-related zinc-finger transcription factors (Snail and Slug). The aim of this study was to evaluate the prognostic impact of EMT-related protein (E-cadherin, Snail and Slug) expression in endometrial cancer. METHODS: An immunohistochemical analysis was conducted using tissue microarray samples of 354 primary tumors and 30 metastases of endometrial carcinomas, and the relationship between protein expression, clinicopathological features and outcomes were investigated. RESULTS: Reduced E-cadherin was seen in 39.8% of primary tumors. Reduced E-cadherin was seen in 19.5%, 40.8% and 72.7% of G₁, G₂ and G₃ endometrioid adenocarcinomas, respectively. The nuclear expression of Snail and Slug were positive in 16.9% and 3.7% of primary tumors, respectively. EMT status, which was represented by both reduced E-cadherin and nuclear expression of Snail, was significantly associated with histological type, FIGO stage, myometrial invasion, positive peritoneal cytology and patient survival (p < 0.01). There was no difference in the rates of EMT status between the primary tumors and metastases. A multivariate analysis showed that EMT-positive status was a significant predictor for both the progression-free survival and overall survival (p < 0.01). CONCLUSIONS: These data indicate that EMT status has a prognostic impact in endometrial cancer. Therefore, the clarification and control of EMT signaling is a promising molecular targeting therapy in endometrial cancer.2013年01月, Cancer biology & therapy, 14(1) (1), 13 - 9, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: GPR30 is a seven-transmembrane G protein-coupled estrogen receptor that regulates endometrial cellular responses to estrogen. GPR30 is often highly expressed in cancer cells from aggressive tumors. The aim of this study was to evaluate the expression patterns of GPR30 in endometriosis during medical treatment. PATIENTS: A total of 38 females, 28 patients with endometriosis and 10 patients with leiomyoma who underwent laparoscopic surgery were included this study. INTERVENTION: Eutopic endometrial tissue sampling from women without endometriosis and ectopic endometrial tissue sampling from women with endometriosis. MAIN OUTCOME MEASURE: A quantitative real-time polymerase chain reaction analysis of the mRNA expression in eutopic and ectopic endometrial tissues with or without GnRH agonist treatment. The expression of GPR30 was confirmed by immunohistochemistry. RESULTS: There was an increased level of GPR30 mRNA in eutopic endometrium during the proliferative phase, whereas higher expression was observed in the ectopic endometrium during the secretory phase. Increased GPR30 mRNA was observed in ectopic endometrium in comparison to eutopic endometrium. GnRH agonist treatment before laparoscopic surgery decreased GPR30 mRNA in ectopic endometrium. The immunohistochemical analysis also revealed that GPR30 was strongly expressed in epithelial cells in ectopic endometrium, whereas GnRH agonist treatment decreased the GPR30 expression. CONCLUSION: High levels of GPR30 expression can play an important role in the progression of endometriosis.2013年, Endocrine research, 38(4) (4), 223 - 31, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIMS: To compare the perinatal outcomes after laparoscopic myomectomy (LM) versus abdominal myomectomy (AM). METHODS: The medical records of 105 Japanese females who delivered after myomectomy from 2004 to 2012 at Osaka Medical College were reviewed retrospectively. RESULTS: Of the 105 females who delivered after myomectomy, 48 had undergone LM and 57 had undergone AM. There were no significant differences in the perinatal outcomes including the rates of emergency cesarean sections, preterm deliveries, placental abnormalities, pregnancy-induced hypertension, low Apgar score, non-reassuring fetal heart rate patterns, and intrauterine fetal death. No significant difference was observed in the incidence of post-partum hemorrhage. There was no uterine rupture in either group. 15 (31%) of the females who had LM were candidates for transvaginal delivery, and 14 delivered vaginally (93% success rate). In contrast, 20 (35%) of the females who had AM were candidates for transvaginal delivery, and 19 delivered vaginally (95% success rate). CONCLUSION: There were no significant differences in the perinatal outcomes between the females who had LM and AM. Moreover, both groups had a high rate of successful transvaginal delivery after selecting the appropriate candidates.2013年, Gynecologic and obstetric investigation, 76(4) (4), 203 - 8, 英語, 国際誌研究論文（学術雑誌）
- Primary carcinoma of the vermiform appendix is a rare disease with few clinical symptoms. Accordingly, preoperative diagnosis of appendiceal cancer is challenging because of the lack of specific symptoms. We herein report a case of appendicular adenocarcinoma found unexpectedly during laparoscopic surgery in a 69-year-old Japanese female patient diagnosed with serous papillary adenocarcinoma, in order to determine whether optimal cytoreduction could successfully be achieved at the time of primary surgery. We performed diagnostic laparoscopic surgery in order to make a correct diagnosis based on the histological tissue. The vermiform appendix was found to contain a tumor measuring 1.5 cm wide and 4.5 cm long. Laparoscopic appendectomy, partial omentectomy, and partial resection of the lesion in the peritoneum were performed. The histological diagnosis was mucinous adenocarcinoma of the vermiform appendix, and the stage was T4NxM1. The patient received adjuvant chemotherapy with mFOLFOX 6 (5FU, leucovorin, and oxaliplatin). She achieved stable disease and was alive with disease eleven months after surgery. We therefore recommend that gynecologists should not rule out the possibility of appendiceal cancer, even in cases with preoperative findings similar to those of serous papillary adenocarcinoma of the peritoneum with peritoneal disseminated tumors.2013年, Case reports in obstetrics and gynecology, 2013, 248917 - 248917, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2013年, 産婦人科の進歩, 65(4) (4), 461 - 464, 日本語
- BACKGROUND: Mature cystic teratomas (MCTs) are the most common germ cell tumors of the ovary. Malignant tranformation occurs in 1-2% of these neoplasms. Although most of the malignancies arising from MCTs are squamous cell carcinomas, adenocarcinoma of the gastrointestinal type is extremery rare. We herein present a case of adenocarcinoma of the intestinal type arising from a MCT. CASE: A 49-year-old female underwent surgery for a left ovarian tumor. The histology of the cyst walls revealed a MCT with a few hair shafts and a squamous layer, while another part of the tumor showed adenocarcinoma of the intestinal type. Five years after surgery, she is alive without disease.2012年12月, Journal of ovarian research, 5(1) (1), 41 - 41, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen receptor that functions alongside traditional estrogen receptors to regulate the cellular responses to estrogen. Recent studies suggest that GPR30 expression is associated with a poor prognosis, and that this is due to the GPR30-mediated transactivation of the EGFR in breast cancer. However, the biological contribution of GPR30 in ovarian cancer remains unclear. The purpose of this study was to elucidate the relationships between GPR30 expression and the clinicopathological findings, and to determine how the signaling cascade influences the prognosis of ovarian cancer. METHODS: The expression levels of GPR30, EGFR, ERα, and ERβ were analyzed using an immunohistochemical analysis, and their correlations with the clinicopathological features were examined in 10 patients with borderline malignant tumors and 152 patients with epithelial ovarian cancer. We also examined whether GPR30 signaling activates the EGFR-Akt pathway in an ovarian cancer cell line (Caov-3) by a Western blotting analysis. RESULTS: The GPR30 expression in ovarian carcinomas was significantly higher than that in borderline malignancies (p=0.0016), and was not associated with the expression of the EGFR, ERα, or ERβ. The expression of GPR30 in clear cell carcinomas was significantly lower than that in other subtypes of cancer (P <; 0.001). The expression of both GPR30 and EGFR was significantly associated with a poor prognosis in terms of the progression-free survival rate. The phosphorylation of the EGFR and Akt could be significantly enhanced by G1 (p <; 0.05) and inhibited by a Src family kinase inhibitor. CONCLUSION: The expression of both GPR30 and EGFR is associated with a poor outcome in ovarian cancer, and GPR30 increases the phosphorylation of Akt via the EGFR in ovarian cancer cells. The regulation of GPR30 might be a potentially useful new therapeutic target in ovarian cancer.2012年11月, Journal of ovarian research, 5(1) (1), 35 - 35, 英語, 国際誌研究論文（学術雑誌）
- 2012年06月, Nihon rinsho. Japanese journal of clinical medicine, 70 Suppl 4, 109 - 13, 日本語, 国内誌[Management of cervical intraepithelial neoplasia].研究論文（学術雑誌）
- 近畿産科婦人科学会, 2012年, 産婦人科の進歩, 64(3) (3), 364 - 366, 日本語
- 腹腔鏡下子宮内膜症手術後に再発する骨盤痛に対してジエノゲストを長期投与した1例を経験したので報告する．症例は，初診時38歳（現在46歳）の2経妊，1経産の女性で，月経期および月経周辺期の骨盤痛を訴えて来院した．低用量ピル（low dose estrogen progestin，以下，LEPと略す）等の内服でも疼痛が持続し，また両側卵巣にチョコレート嚢胞を認めたので腹腔鏡下手術を行い子宮内膜症のrevised american society for reproductive medicine （r-ASRM） stage IVと診断した．同時に両側付属器周囲癒着剥離術，両側チョコレート嚢胞摘出術，ダグラス窩癒着剥離術，子宮筋腫核出術を施行し，術後2年間にわたり再びLEPを投与したが，しだいに疼痛が増強したためジエノゲスト2mg/日を22週の休薬期間を挟んで56週と81週の合計137週にわたり長期投与し，疼痛はほぼ軽快した．治療中，軽度のめまいと少量の不正出血以外に明らかな有害事象は認められなかった．ジエノゲストは子宮内膜症の術後に行う薬物療法の有望な選択肢であり，長期にわたって有効かつ安全に使用できる可能性がある．〔産婦の進歩64（1）：41-48，2012（平成24年2月）〕近畿産科婦人科学会, 2012年, 産婦人科の進歩, 64(1) (1), 41 - 48, 日本語
- Interstitial pregnancy, which is a rare form of tubal ectopic pregnancy, can grow larger than those within the fallopian tube because the surrounding myometrium is more expandable than the tube; many cases are advanced and treated with surgical resection or a large amount of methotrexate (MTX). This report presents a case of an advanced interstitial pregnancy treated with systemic MTX and laparoscopic local MTX injection combined with transcervical aspiration of the gestational sac. A 27-year-old nulliparous female presented with an interstitial pregnancy. Serum human chorionic gonadotropin (hCG) level was 90000 IU/L. MTX was given systemically (50 mg/m(2) i.m.) and the gestational sac was aspirated transcervically under laparoscopic guidance followed by local injection of 25 mg MTX. The patient received a total of only 95 mg MTX. The gestational sac disappeared and serum hCG became undetectable. The patient became pregnant spontaneously six months later, and delivered a live 2482-g infant in good condition by planned cesarean section at 36 weeks and 3 days of gestation. No defect of the myometrium was seen during the surgery. This therapy may be effective for interstitial pregnancy and can be performed safely with laparoscopy.2011年09月, The journal of obstetrics and gynaecology research, 37(9) (9), 1250 - 4, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本婦人科腫瘍学会, 2011年06月, 日本婦人科腫瘍学会雑誌, 29(3) (3), 583 - 583, 日本語子宮体癌における筋層浸潤の予後への影響とリンパ節郭清の意義
- 「産婦人科の進歩」編集室, 2011年05月, 産婦人科の進歩, 63(2) (2), 241 - 241, 日本語
- OBJECTIVE: To evaluate how endometriosis affects the expression of estrogen and progesterone receptors mRNA in granulosa cells. DESIGN: Prospective study. SETTING: IVF-ET program at Osaka Medical College. PATIENT(S): Eighteen patients with revised American Fertility Society stage IV endometriosis and 23 patients with tubal infertility without endometriosis. INTERVENTION(S): Granulosa cells obtained from patients with endometriosis were examined for estrogen (ER-β, ER-α) and progesterone (PR-A, PR-B) receptor mRNA expression ratio against GAPDH. MAIN OUTCOME MEASURE(S): Hormonal environment and clinical outcome were investigated. Expression of ER and PR mRNA were evaluated by StepOne real-time polymerase chain reaction (PCR) analysis. RESULT(S): Total hMG/FSH levels were statistically higher in patients with endometriosis; however, high-quality embryo rates and pregnancy rates were lower in patients with endometriosis than in patients with tubal infertility. Expression of PR-A and ER-α in patients with endometriosis was statistically higher than in patients with tubal infertility. The expression of PRs and ERs in patients with tubal infertility showed a positive correlation; however, it was not identified in the endometriosis group. CONCLUSION(S): The higher PR-A and ER-α gene expression in granulosa cells in patients with endometriosis, compared with patients with tubal infertility, might be a leading cause of ovarian dysfunction due to endometriosis.2011年03月, Fertility and sterility, 95(3) (3), 889 - 94, 英語, 国際誌研究論文（学術雑誌）
- Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer.OBJECTIVES: We herein assessed the influence of Epidermal Growth Factor Receptor (EGFR) gene mutations on EGFR expression levels, downstream mediators such as Akt or ERK, and overall survival in patients with ovarian cancer. STUDY DESIGN: EGFR mutation status was analyzed by direct sequencing in 102 Japanese ovarian cancer patients. The EGFR expression, phosphorylated Akt (pAkt), and phosphorylated ERK (pERK) were determined by immunohistochemistry. RESULTS: Twenty-nine EGFR gene mutations were detected in 24 of 102 patinets (23.5%). EGFR mutations were observed in 27.9% (19/68) in serous adenocarcinomas, 15.0% (3/20) in clear cell adenocarcinomas, and 66.7% (2/3) in mucinous adenocarcinomas, while no mutations were observed in endometrioid adenocarcinomas (0/11). Protein expression of EGFR, pAkt, and pERK were detected in 47 (46.1%), 49 (48%), and 17 (16.7%) of patients, respectively. EGFR gene mutations, EGFR and pERK expression were not associated with a poor prognosis. In a multivariate analysis, a High pAkt expression was found to be a significant predictor for both the progression free survival (p=0.017) and overall survival (P=0.025). CONCLUSION: EGFR gene mutations were frequently observed in not only non-small-cell lung cancer (NSCLC), but also in ovarian cancer in Japanese patients. the selective EGFR inhibitor Gefitinib might therefore offer some benefit in patients with EGFR mutations in ovarian cancer. Our results indicate that the Akt, but not necessarily EGFR, is one of the most important target in the response of the platinum-based chemotherapy and prognosis for ovarian cancer patients.2011年01月, Cancer biology & therapy, 11(1) (1), 50 - 7, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2011年, 産婦人科の進歩, 63(3) (3), 356 - 358, 日本語
- OBJECTIVE: To report a case of mature cystic teratoma of the fallopian tube. DESIGN: Case report. SETTING: Medical college-affiliated hospital. PATIENT(S): A 31-year-old woman, gravida 0, visited our outpatient clinic with infertility. Hysterosalpingography (HSG) showed a swollen right fallopian tube whose patency was not confirmed. INTERVENTION(S): Laparoscopic right salpingectomy was perfomed for a solid-appearing mass ∼2 × 1.5 cm in diameter in the ampullary region. Histopathologic examination showed components from each germ cell layer; therefore, the diagnosis of a mature cystic teratoma of the right fallopian tube was confirmed. The patient became pregnant with IVF-ET and gave birth to a baby boy. CONCLUSION(S): In cases where hydrosalpinx is suspected, a careful assessment by either HSG or laparoscopy is necessary at the time of infertility examination.2010年12月, Fertility and sterility, 94(7) (7), 2708 - 9, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Topotecan, a novel topoisomerase-1 inhibitor, is a drug that appears to be effective against platinum-resistant ovarian cancers. However, the molecular mechanisms by which Topotecan treatment inhibits cancer cell proliferation are unclear. We investigated whether Topotecan increases the efficacy of Cisplatin in platinum-resistant ovarian cancer models in vitro and in vivo. METHODS: We used Cisplatin-resistant Caov-3 cells and Cisplatin-sensitive A2780 cells. We examined the effect of Cisplatin and Topotecan on the cell viability of Caov-3 and A2780 cells by MTS assay. We examined the Akt kinase activity, VEGF and HIF-1α expression after Cisplatin and Topotecan by a Western blot analysis. Moreover, we also evaluated the effects of Cisplatin and Topotecan on the intraabdominal dissemination of ovarian cancer in vivo. RESULTS: Topotecan significantly inhibited Cisplatin-induced Akt activation in Caov-3 cells, but not in A2780 cells. In the presence of Topotecan, Cisplatin-induced growth inhibition and apoptosis were significantly enhanced in Caov-3 cells. Topotecan inhibited not only Cisplatin-induced Akt activation but also VEGF and HIF-1α expression. Moreover, treatment with Topotecan increased the efficacy of Cisplatin-induced growth inhibition in the intraabdominal dissemination and production of ascites in athymic nude mice inoculated with Caov-3 cells. CONCLUSION: We herein demonstrated that Topotecan inhibits Akt kinase activity and VEGF transcriptional activation after Cisplatin treatment in platinum-resistant ovarian cancers. We clarified how Topotecan enhanced the clinical activity in the platinum-resistant ovarian cancer. These results provide a rationale for using Topotecan in clinical regimens aimed at molecular targeting agents in platinum-resistant ovarian cancers.2010年12月, Cancer biology & therapy, 10(11) (11), 1137 - 46, 英語, 国際誌研究論文（学術雑誌）
- 2010年08月, MOLECULAR CANCER THERAPEUTICS, 9(8) (8), 2411 - 2422, 英語, 国際誌研究論文（学術雑誌）
- During human pregnancy, trophoblasts play an important role in embryo implantation and placental development. Cytotrophoblast cells invade the uterine spiral arteries and differentiate into extravillous trophoblasts, resulting in the remodeling of the uterine vessels and fetoplacental vasculature. During early pregnancy, a physiologically hypoxic environment induces the production of angiogenic factors, such as vascular endothelial growth factor (VEGF), which are suggested to locally control the vascular remodeling. Endoglin, a cell-surface coreceptor for transforming growth factor-beta1, is highly expressed in endothelial cells and syncytiotrophoblasts, and can be associated with endothelial nitric oxide synthase and vascular homeostasis. Several studies have recently suggested that some pregnancy-related complications, such as preeclampsia, have their origins early in pregnancy as a result of abnormalities in implantation and placental development. Although angiogenic factors are recognized as key molecules in placental development, little is known about the mechanism(s) of their regulation in trophoblasts. In this study, we elucidated the mechanisms underlying the regulation of VEGF and endoglin production under hypoxic conditions in the trophoblast-derived cell line, BeWo. We evaluated the role of the AKT-MTOR cascade and ERK kinase in the expression of VEGF and endoglin in response to hypoxia using various kinase inhibitors and small interfering RNA targeted against hypoxia-inducible factor (HIF)-1alpha (listed as HIF1A in Hugo Database). Our results suggest that both the phosphatidylinositol 3-kinase-AKT-MTOR-HIF-1alpha and ERK-HIF-1alpha signaling pathways are crucial for increasing VEGF and endoglin expression in response to hypoxia in BeWo cells.2010年07月, The Journal of endocrinology, 206(1) (1), 131 - 40, 英語, 国際誌研究論文（学術雑誌）
- Relationship between ABCF2 expression and response to chemotherapy or prognosis in clear cell adenocarcinoma of the ovary.OBJECTIVES: The purpose of this study was to evaluate the association of ABCF2 (adenosine triphosphate-binding cassette superfamily F2) protein expression with response to chemotherapy and prognosis in patients with clear cell adenocarcinoma (CCC) of the ovary. METHODS: One hundred sixty-five patients with CCC were studied, and cytoplasmic ABCF2 expression was detected by immunohistochemical staining. All patients underwent platinum-based primary chemotherapy followed by primary surgery. RESULTS: Adenosine triphosphate-binding cassette superfamily F2 expression was detected in 118 (71.5%) of 165 patients and was not related to age or clinical stage. The response rate to chemotherapy in 38 patients with measurable disease was 47.3% (18/38). The response rate tended to be higher in patients without ABCF2 expression than in those with ABCF2 expression; however, this difference was not significant (66.7% vs 34.8%, P = 0.096). There was no significant difference in overall survival between ABCF2-positive and ABCF2-negative cases (median survival time, 1175 vs 1257 days; P = 0.24). CONCLUSIONS: Adenosine triphosphate-binding cassette superfamily F2 protein was highly expressed in CCC of the ovary, but expression was not related to age, clinical stage, chemoresponse, or prognosis.2010年07月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 20(5) (5), 794 - 7, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: Epithelial ovarian cancer (EOC) can be classified into 5 major histological types. Among them, clear cell adenocarcinoma (CCC) has a poor response to chemotherapy and poor prognosis compared with other histological types. Previously, we reported that the hypoxia-inducible protein 2 (HIG2) gene might be a new biomarker for CCCs, based on its expression profile. In this study, we generated a polyclonal antiserum to HIG2 to explore the use of HIG2 as a predictive biomarker in EOC. In addition, HIG2 expression was evaluated in uterine endometrial and renal CCCs. METHODS: Hypoxia-inducible protein 2 expression was analyzed by immunohistochemistry in formalin-fixed surgical samples from 254 EOC, 17 endometrial, and 29 renal CCC patients. RESULTS: Hypoxia-inducible protein 2 is expressed in 175 of 254 ovarian cancer cases. Cytoplasmic HIG2 expression is significantly more frequent in ovarian CCC (83.1%) than in serous (54.9%, P = 0.0001), mucinous (40%, P = 0.00002), or endometrioid (58.1%, P = 0.003) adenocarcinoma. The chemoresponse rate was higher in 24 ovarian CCC patients with cytoplasmic HIG2 expression than in 6 CCC patients without HIG2 expression (62.5% [15/24] vs 0% [0/6], P = 0.02). In contrast, there was no relationship between nuclear HIG2 expression and chemoresponse. Cytoplasmic and nuclear HIG2 expressions are significantly more frequent in ovarian and uterine than renal CCC (P = 0.04). CONCLUSIONS: Hypoxia-inducible protein 2 may be used as a marker for early detection of ovarian CCCs or for prediction of response to chemotherapy, but HIG2 expression does not predict survival of patients with CCC.2010年02月, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 20(2) (2), 220 - 6, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2010年, 産婦人科の進歩, 62(1) (1), 32 - 34, 日本語
- 近畿産科婦人科学会, 2010年, 産婦人科の進歩, 62(3) (3), 255 - 257, 日本語
- OBJECTIVE: To report a case of successful pregnancy after conservative surgery for stage 1A endometrial cancer. DESIGN: Case report. SETTING: University hospital. PATIENT(S): A 33-year-old woman who was diagnosed with stage IA endometrial cancer. INTERVENTION(S): Conservative surgery and chemotherapy. MAIN OUTCOME MEASURE(S): Clinical outcome. RESULT(S): After administering medroxyprogesterone acetate (MPA) for 6 weeks, hysterofiberscopy showed that the restricted lesions still remained. A partial resection of the lesions was therefore performed. The patient delivered a girl by cesarean section after the surgery. CONCLUSION(S): Conservative surgery after MPA treatment may be a new treatment option for patients who wish to preserve their fertility.2009年03月, Fertility and sterility, 91(3) (3), 936.e13-5, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To report a case of a methotrexate (MTX)-resistant heterotopic interstitial pregnancy in which dactinomycin was necessary as a second-line chemotherapy. DESIGN: Case report. SETTING: Medical college-affiliated hospital. PATIENT(S): A 39-year-old woman with vaginal bleeding after the transfer of two thawed 8-cell embryos. INTERVENTION(S): MTX 50 mg/m(2) was given to the patient to treat a concomitant pregnancy in which an interstitial pregnancy and an intrauterine blighted ovum were identified. However, the patient's hCG level rose despite two MTX administrations. As a result, dactinomycin was then administered as a second-line chemotherapy. The patient's serum hCG level declined to a normal range after two administrations of dactinomycin. CONCLUSION(S): Dactinomycin could be an alternative in cases for which MTX is not effective and persistently high hCG levels exist.2009年03月, Fertility and sterility, 91(3) (3), 929.e13-5, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: We report the therapeutic potential, longterm survival, and toxicity of neoadjuvant intraarterial chemotherapy (NAIC) using an original four-lumen double-balloon (4L-DB) catheter followed by radical hysterectomy and/or radiotherapy in patients with locally advanced cervical cancer. METHODS: Sixty patients with stage IIB-IVA cervical squamous cell cancer were treated with NAIC which included cisplatin (60-70 mg/m(2), day 1), mitomycin-C (10-20 mg/m(2), day 1), and pirarubicin hydrochloride (THP; 10-20 mg/m(2), day 1) for two courses every 21 days. RESULTS: The median follow up among surviving patients was 93.7 months. Among 60 eligible patients, 22 had a complete response (CR; 36.7%) including 12 with a pathologic CR (20.0%). Thirty-six patients had a partial response (60.0%), and stable disease was observed in only 2 patients (3.3%). Moreover, we found that the platinum concentration in the cervix was correlated with the clinical response (P < 0.001). The 10-year progression-free survival (PFS) and 10-year survival were 90.9% and 90.9%, respectively, in patients with stage IIB disease and 66.0% and 70.7%, respectively, in patients with stage III disease. Leukopenia occurred in 86.7% of patients, but it was not very severe (grade 3, 4 in 13.3% of patients). CONCLUSION: Our results with NAIC using the 4L-DB catheter in locally advanced cervical cancer demonstrate that a high platinum concentration has beneficial effects on primary lesions and improves long-term progression-free and overall survival.2009年02月, International journal of clinical oncology, 14(1) (1), 56 - 62, 英語, 国内誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2009年, 産婦人科の進歩, 61(1) (1), 17 - 20, 日本語
- 近畿産科婦人科学会, 2009年, 産婦人科の進歩, 61(1) (1), 61 - 64, 日本語
- 近畿産科婦人科学会, 2008年, 産婦人科の進歩, 60(2) (2), 105 - 107, 日本語
- Mitochondrial gene expression in granulosa cells of severe endometriosis with in vitro fertilization and embryo transfer.The expression of mitochondrial genes in granulosa cells was quantitated by real-time polymerase chain reaction. The expression ratio of mitochondrial genes in granulosa cells of patients with severe endometriosis showed no statistically significant difference compared with cases of tubal infertility without endometriosis.2007年12月, Fertility and sterility, 88(6) (6), 1703 - 5, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2007年, 産婦人科の進歩, 59(4) (4), 287 - 289, 日本語
- 近畿産科婦人科学会, 2007年, 産婦人科の進歩, 59(2) (2), 153 - 155, 日本語
- 近畿産科婦人科学会, 2007年, 産婦人科の進歩, 59(1) (1), 20 - 22, 日本語
- 近畿産科婦人科学会, 2007年, 産婦人科の進歩, 59(2) (2), 92 - 94, 日本語
- Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer.OBJECTIVE: To determine the association of human papillomavirus (HPV) infection with the expression of dihydrodiol dehydrogenase (DDH) in uterine cervical cancer (UCC). METHODS: In situ hybridization (ISH) and immunohistochemistry were applied to examine pathological specimens of 145 patients with UCC. RESULTS: By ISH, HPV16/18 DNA was detected in 108 (74.5%) UCC cases. DDH expression determined by immunohistochemistry was detected in 81 (75%) lesions among 108 HPV-positive cases. In contrast, of 37 HPV-negative cases, DDH was only detected in 16 (43.2%) of the lesions. A significant correlation was found between DDH expression and the presence of HPV (P < 0.001), FIGO stage (P = 0.004), lymph node involvement (P < 0.001), as well as patients' survival (P = 0.002). In vitro, DDH expression was also found closely associated with HPV infection, and DDH content was proportional to cell sensitivity for cisplatin and doxorubicin. CONCLUSIONS: HPV infection provokes local inflammation, which can then induce DDH expression and drug resistance in UCC. The detailed biological relationship among HPV infection, expression of DDH and drug resistance, however, remains to be clarified.2006年08月, Gynecologic oncology, 102(2) (2), 173 - 81, 英語, 国際誌研究論文（学術雑誌）
- Transcriptional expression of survivin and its splice variants in endometriosis.Survivin is a novel inhibitor of apoptosis (IAP), and the two splice variants of survivin (survivin-2B and survivin-EX3) have been identified. Gene expression levels of survivin, survivin-2B and survivin-EX3 in 56 ectopic (16 peritoneal red and 16 peritoneal black lesions and 24 ovarian endometriomata) and 13 eutopic endometrial tissues surgically obtained from 42 women with endometriosis (group A) were compared with those in 16 control eutopic endometrium from 16 women without endometriosis (group B) by quantitative RT-PCR analysis. Survivin mRNA expression levels in ectopic endometriotic tissues were significantly higher than those in eutopic endometrium of groups A and B over the whole cycle. Red peritoneal lesions had higher gene expression levels of survivin than black lesions. In contrast, all tissue samples examined showed relatively lower gene expression levels of survivin-2B and survivin-EX3. No cyclic variation was found in survivin and the two splice variants, both in ectopic and in eutopic endometrium. Although there was no significant difference in the ratio of survivin-2B/survivin between ectopic and eutopic endometrium, the ratio of survivin-EX3/survivin in peritoneal endometriotic lesions was significantly higher than that of eutopic endometrium of groups A and B. These results suggest that survivin and survivin-EX3 may be closely linked to escape from apoptosis and the development of endometriosis.2006年06月, Molecular human reproduction, 12(6) (6), 383 - 8, 英語, 国際誌研究論文（学術雑誌）
- Diagnostic and therapeutic laser conization for cervical intraepithelial neoplasia.OBJECTIVE: The clinical efficacy of conservative treatment using Nd-YAG laser technique for cervical intraepithelial neoplasia (CIN) was evaluated in a large series of CIN patients based on the long-term follow-up results. METHODS: We have treated 2107 women preoperatively diagnosed as having CIN by Nd-YAG contact laser conization with vaporization of the base. Their postoperative histologic findings and clinical outcomes were evaluated. RESULTS: The cone specimen was reported as showing that 1956 (92.8%) of 2107 cases had no CIN or CIN 1-3 and 151 (7.2%) cases had invasive diseases. 1956 cases without invasive diseases were followed up for 16 to 252 months. Incomplete excision occurred in 230 (12.3%) of 1874 patients with CIN lesion in the cone specimen, but failure rate (persistence or recurrence) was only 1.2%. 192 (83.5%) of 230 postoperative CIN patients with positive surgical margins showed no abnormal cytology or colposcopy during follow-up period. Preoperative underdiagnosis of biopsy results compared with cytologic or colposcopic findings elevated the risk for incomplete excision and failure rate. CONCLUSION: The combination of laser excision and vaporization of the base was useful to detect unexpected invasive disease and revealed excellent therapeutic effects for CIN. Preoperative cytologic or colposcopic findings should be taken into account for the conservative treatment of CIN.2006年04月, Gynecologic oncology, 101(1) (1), 143 - 6, 英語, 国際誌研究論文（学術雑誌）
- Germline polymorphism of p53 codon 72 in gynecological cancer.OBJECTIVE: To investigate the biological significance of single nucleotide polymorphism at codon 72 of the p53 gene in the development of gynecological cancer. METHODS: p53 codon 72 polymorphism was examined in a total of 354 blood samples from 95 normal, 83 cervical, 108 endometrial and 68 ovarian cancer cases using polymerase chain reaction and restriction fragment length polymorphism techniques. RESULTS: When p53 codon 72 genotype was classified into two subgroups of Arg/Arg and Arg/Pro + Pro/Pro, the Arg/Arg genotype was associated with an increased risk for the development of endometrial cancer (OR = 1.86, 95% CI = 1.06 to 3.26) compared with the Arg/Pro + Pro/Pro genotype (P = 0.0301). The Arg allele also increased the risk of endometrial cancer (OR = 1.42, 95% CI = 0.93 to 1.52) compared with the Pro allele, but no statistical difference was found (P = 0.1031). There was no significant difference in the genotype or allele prevalence between control subjects and cervical or ovarian cancer patients. CONCLUSION: Homozygous Arg at codon 72 of the p53 gene may be a risk factor for developing endometrial cancer in a Japanese population.2006年01月, Gynecologic oncology, 100(1) (1), 173 - 8, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2006年, 産婦人科の進歩, 58(4) (4), 388 - 392, 日本語
- 子宮頸部すりガラス細胞癌（glassy cell carcinoma : GCC）は全頸癌の 1～2 %とまれであり，放射線療法や化学療法に対して抵抗性を示すことから予後不良とされている．今回われわれは動注化学療法後に根治手術を行い，放射線化学療法を追加して予後良好であったGCCIIIb期の1例を経験したので報告する．症例は37歳の未妊婦で不正性器出血を主訴に近医を受診し，頸癌の疑いで当科紹介となった．初診時，子宮腟部はカリフラワー状の易出血性腫瘤により占拠されており，右傍結合織に骨盤壁に達する抵抗が触知された．頸部擦過細胞診はクラスV，生検組織診でGCCが検出された．GCCIIIb期との診断で，動注化学療法（CDDP:100mg + MMC:20mg + THP:20mg + 5-FU:500mg）2コースを行ったところ，腫瘍の著明な縮小がみられたため，広汎性子宮全摘出術，両側付属器摘出術および骨盤リンパ節郭清術を施行した．追加治療として全身化学療法（CDDP:20mg + 5-FU:300mg 5日連続投与）3コースを併用して全骨盤照射50.4 Gyを施行した．治療終了後4年が経過しているが，現在まで再発徴候は認められない．術前動注化学療法，根治手術，術後放射線化学療法からなる集学的治療はGCCの予後向上に役立つ可能性がある．〔産婦の進歩58（4）：351-355，2006（平成18年11月）〕近畿産科婦人科学会, 2006年, 産婦人科の進歩, 58(4) (4), 351 - 355, 日本語
- Transcriptional expression of the genes implicated in angiogenesis and tumor invasion in cervical carcinomas.OBJECTIVE: Co-expression patterns of the genes implicated in angiogenesis and tumor invasion in cervical carcinoma cells were investigated together with invasive activity of tumor cells. Transcript levels of those genes were also compared between tumor cells and normal cervical tissues. METHODS: Real-time quantitative RT-PCR analysis was conducted on selected 11 genes (total VEGF-A, VEGF(121), VEGF(165), VEGF(189), VEGF-B, C and D, bFGF, dThdPase, MMP-2 and uPA) using 11 cervical carcinoma cell lines and 14 normal cervical tissues. Protein expression of VEGF-C and MMP-2 and invasive activity of tumor cells were evaluated for each cell line by sandwich ELISA and haptoinvasion assay, respectively. RESULTS: Gene co-expression analysis revealed the significant correlation between angiogenic factors and proteinases in malignant but not in normal cervical samples. Gene or protein expression levels of VEGF-C and MMP-2 were well correlated with the number of invaded tumor cells. VEGF-A splicing variants were increased in malignant compared to normal cervical samples but not associated with the invasive activity of the cells. CONCLUSION: VEGF-C and MMP-2 were closely related to invasive phenotype of tumor cells, whereas VEGF-A isoforms were considered to be involved in cervical carcinogenesis.2005年09月, Gynecologic oncology, 98(3) (3), 453 - 61, 英語, 国際誌研究論文（学術雑誌）
- Fas gene promoter -670 polymorphism (A/G) is associated with cervical carcinogenesis.OBJECTIVE: To investigate the biological significance of single nucleotide polymorphism (SNP) at Fas gene promoter in cervical carcinogenesis. METHODS: SNP at -670 of Fas gene promoter (A/G) together with human papillomavirus (HPV) types were examined in a total of 279 cervical smear samples and 8 human cervical squamous carcinoma cell lines using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) techniques. RESULTS: 49 patients with high-grade squamous intraepithelial lesion (HSIL) had higher frequency of high-risk HPV and GA + GG genotype than 167 with low-grade SIL (LSIL) and 63 controls. G allele frequency was also higher in HSIL than in LSIL and controls. There was an increased OR (6.00; CI, 1.32-27.37; P = 0.021) for GA + GG genotype in HSIL cases compared to controls among 96 patients with high-risk HPV. 7 of 8 cervical carcinoma cell lines also showed GA or GG genotype. CONCLUSION: Fas gene promoter -670 polymorphism (A/G) may be closely associated with cervical carcinogenesis in a Japanese population.2005年07月, Gynecologic oncology, 98(1) (1), 129 - 33, 英語, 国際誌研究論文（学術雑誌）
- Vascular endothelial growth factor-C expression and invasive phenotype in ovarian carcinomas.PURPOSE: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype in ovarian carcinomas. EXPERIMENTAL DESIGN: Gene and protein expression levels of VEGF-C in 10 ovarian carcinoma cell lines were correlated with invasive activity of the cells. The correlation between immunohistochemical expression of VEGF-C and tumor aggressiveness in 73 ovarian carcinomas was also examined with respect to clinicopathologic features and patient outcome. RESULTS: VEGF-C gene and protein expression differed remarkably among the cell lines, and there was a statistical correlation among VEGF-C expression, in vitro invasive activity, and matrix metalloproteinase-2 (MMP-2) gene expression and its activity. Anti-VEGF-C and anti-MMP-2 antibodies inhibited the invasive activity of tumor cells. VEGF-C expression in clinical tissue samples was well correlated with clinical stages, retroperitoneal lymph node metastasis, MMP-2 expression, angiogenesis, lymphangiogenesis, and low apoptotic index (AI). The patients whose tumors had strong VEGF-C expression and low AI underwent a poorer prognosis than did those with weak VEGF-C expression and high AI. CONCLUSION: VEGF-C expression is closely related to invasive phenotype and affects the patient's survival in ovarian carcinomas.2005年05月, Clinical cancer research : an official journal of the American Association for Cancer Research, 11(9) (9), 3225 - 32, 英語, 国際誌研究論文（学術雑誌）
- Glutathione-S-transferase and p53 polymorphisms in cervical carcinogenesis.OBJECTIVE: To investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 polymorphisms in cervical carcinogenesis. METHODS: GSTM1, GSTT1 and p53 codon 72 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 198 cervical smear samples using multiplex polymerase chain reaction (PCR) and PCR restriction fragment length polymorphism (RFLP) techniques. RESULTS: Forty-two patients with high-grade squamous intraepithelial lesion (HSIL) had higher frequency of high-risk HPV and null GSTT1 genotype than 102 with low-grade SIL (LSIL) and 54 controls. Thirty-one patients with HSIL had also statistically higher frequency of null GSTT1 genotype than 28 with LSIL among 69 patients with high-risk HPV. There was no statistical difference in p53 Arg, Arg/Pro and Pro genotypes between SILs and controls with or without high-risk HPV. CONCLUSION: GSTT1 null genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population. The p53 codon 72 polymorphism is unlikely to be related to HPV status and the onset of cervical cancer.2005年03月, Gynecologic oncology, 96(3) (3), 736 - 40, 英語, 国際誌研究論文（学術雑誌）
- Tumor angiogenesis and molecular target therapy in ovarian carcinomas.Growth of solid tumors depends on angiogenesis, the process by which new blood vessels develop from the endothelium of a pre-existing vasculature. Tumors promote angiogenesis by secreting various angiogeneic factors, and newly formed blood vessels induce tumor cell proliferation and invasiveness. Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. The degree of angiogenesis of ovarian carcinomas may directly influence the clinical course of the disease. Although a growing body of evidence indicates that angiogenic intensity may play a prognostic role in gynecological malignancies including ovarian carcinomas, the related biological mechanisms remain to be further elucidated. In this review, we describe current knowledge pertaining to mechanisms and regulation of angiogenesis in ovarian carcinomas with special reference to our recent research results.2005年03月, Human cell, 18(1) (1), 1 - 16, 英語, 国内誌研究論文（学術雑誌）
- Vascular endothelial growth factor A and C gene expression in endometriosis.Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle (P <0.01) and increased in the secretory phase. VEGF-A gene expression in peritoneal endometriotic lesion was statistically higher than that in normal peritoneum (P <0.01) and similar to that in eutopic endometrium of group 2. In contrast, gene expression levels of VEGF-C were relatively lower than those of VEGF-A in each lesion, and no cyclic variation was found. VEGF-A and C mRNA expression levels were significantly higher in ovarian endometriomas >6 cm in size than in those <6 cm in size. Immunohistochemical expression of VEGF-A and C was detected in the cytoplasm of glandular epithelial and stromal cells of ovarian endometrioma. These results suggest that endometriosis may arise from eutopic endometrium with higher levels of angiogenic activity possibly induced by VEGF-A in women with endometriosis. Moreover, VEGF-C as well as VEGF-A may be involved in the pathogenesis of ovarian endometrioma.2004年11月, Human pathology, 35(11) (11), 1369 - 75, 英語, 国際誌研究論文（学術雑誌）
- Conservative excisional laser conization for early invasive cervical cancer.OBJECTIVE: To investigate the possibility of conservative excisional laser conization for early invasive cervical cancer. METHODS: Four hundred one women with early invasive squamous cell cancer were treated by laser conization and semiradical or radical hysterectomy with pelvic lymphadenectomy. Their histologic findings and clinical outcomes were evaluated retrospectively. RESULTS: Two hundred Ia1 cases without confluent invasion or vessel permeation receiving only laser therapy had no recurrent disease. There was no lymph node metastasis in 123 Ia1 and 24 Ia2 cases with stromal invasion of under 4 mm in depth regardless of confluent invasion and vessel permeation. However, lymph node metastasis was detected in 1 of 13 Ia2 cases with stromal invasion of over 4 mm in depth and in 5 of 41 Ib1 cases. All of these six cases had vessel permeation in the resected specimens. CONCLUSION: Conservative excisional laser conization may be possible for stage Ia cervical cancer with stromal invasion of under 4 mm in depth. However, the risk of lymph node metastasis should be still considered for those lesions with vessel permeation.2004年10月, Gynecologic oncology, 95(1) (1), 231 - 4, 英語, 国際誌研究論文（学術雑誌）
- 2004年10月, Nihon rinsho. Japanese journal of clinical medicine, 62 Suppl 10, 88 - 92, 日本語, 国内誌[Management of dysplasia of the uterine cervix].研究論文（学術雑誌）
- 近畿産科婦人科学会, 2004年, 産婦人科の進歩, 56(3) (3), 318 - 321, 日本語
- 近畿産科婦人科学会, 2004年, 産婦人科の進歩, 56(3) (3), 310 - 310, 日本語
- Glutathione S-transferase GSTM1, GSTT1 and p53 codon 72 polymorphisms in human tumor cells.The genes of the glutathione S-transferase (GST) family encode enzymes that appear to be critical in cellular protection against the cytotoxic effects, whereas p53 is a tumor suppressor gene. Despite a large number of studies on germline polymorphisms of GSTM1, GSTT1 and p53 genes, there have been very few reports on genotyping of these genes in human malignant tumor cells. In this study, we investigated GSTM1, GSTT1 and p53 codon 72 polymorphisms in a variety of human tumor cell lines originating from different organs to clarify tissue-specific polymorphic frequency of these genes in human solid tumors. The GSTM1 and GSTT1 genetic polymorphisms were evaluated using multiplex PCR techniques and PCR-RFLP analysis was conducted to identify p53 codon 72 genotypes. Gene expression of GSTM1 or GSTT1 was detected by RT-PCR in the cells with respective present genotype for each. Polymorphisms of p53 codon 72 detected by PCR-RFLP were also confirmed using SSCP and sequence analyses. GSTM1 and GSTT1 genotypes were various in 104 cell lines examined. Null GSTM1 genotype was dominant in small cell lung, kidney and ovarian carcinoma cells, whereas null GSTT1 genotype was dominant in cervical and endometrial carcinoma cells. GSTM1 and GSTT1 genotypes in ovarian carcinoma cells were quite similar to those in small cell lung carcinoma cells. Polymorphic frequency of p53 codon 72 was also various among the cells, however, the Pro allele was found in only 1 of 6 kidney, 14 cervical and 4 endometrial carcinoma cell lines. There was a significant difference in GSTM1 and p53 genotypes between 34 small cell and 24 non small cell lung carcinoma cells (P < 0.01). Combined study on the distribution of GSTM1, GSTT1 and p53 genotypes revealed that null GSTM1 genotype was associated with the Arg allele of p53 codon 72 in 58 lung carcinoma cells and null GSTT1 genotype was associated with the Pro/Pro homozygote in 104 tumor cell lines examined. This is the first study examining GSTM1, GSTT1 and p53 codon 72 polymorphisms in a variety of human solid tumor cells and suggesting that polymorphic frequency of these genes may be tissue- and organ-specific. The molecular interaction between GST gene defects and p53 codon 72 genotype in the development of human malignant tumors should be further investigated.2003年12月, Human cell, 16(4) (4), 241 - 51, 英語, 国内誌研究論文（学術雑誌）
- Homeobox gene expression and mutation in cervical carcinoma cells.An association between deregulation of homeobox (HOX) gene expression and oncogenic transformation has been recently reported in human tumors. In this study, we investigated HOX gene expression and mutation in cervical carcinoma cells. Using reverse transcription-PCR, 11 human cervical carcinoma cell lines and 14 normal cervical tissue samples were examined for mRNA expression of the 39 class I HOX genes. DNA samples from 11 cell lines were tested for mutations in exons 1 and 2 of the HOXA10 and A13 genes using overlapping primer pairs which also cover intron 1 of these genes. HOXA1, B2, B4, C5, C10 and D13 genes were expressed in 8, 7, 9, 9, 9 and 11 of 11 cervical carcinoma cell lines, respectively, but not in any of the normal cervical tissues. HOXA9, A11, A13, B5, C4, D3 and D9 genes were expressed in all cell lines and normal tissues. In contrast, 13 of 39 HOX genes were silent in all materials examined. Single-strand conformational polymorphism and sequence analysis revealed a C insertion after base 1042 and/or a G to C substitution at base 1113 in intron 1 of the HOXA13 gene in 4 of 11 cell lines, however, neither deletions nor mutations were detected in exons 1 and 2 of the HOX A10 and A13 genes. Our data suggest that the expression of HOXA1, B2, B4, C5, C10 and D13 genes might be involved in the process leading to the transformation of normal cervical cells.2003年05月, Cancer science, 94(5) (5), 437 - 41, 英語, 国際誌研究論文（学術雑誌）
- 近畿産科婦人科学会, 2003年, 産婦人科の進歩, 55(1) (1), 33 - 35, 日本語
- Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin-6 in granulosa cells from patients undergoing controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer.OBJECTIVE: To evaluate how endometriosis affects expression of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) in granulosa cells. DESIGN: Prospective study. SETTING: IVF-ET program at Osaka Medical College. PATIENT(S): Seventeen patients with revised American Fertility Society stage IV endometriosis and 17 patients with tubal infertility and no endometriosis. INTERVENTION(S): Granulosa cells obtained at oocyte retrieval were examined for VEGF and IL-6 gene expression. MAIN OUTCOME MEASURE(S): Serum E(2) and P levels at hCG administration, number of oocytes, fertilization rate, high-quality embryo rate, and pregnancy rate, and expression of VEGF and IL-6 genes. RESULT(S): Total hMG and FSH levels were statistically significantly higher in patients with endometriosis; however, the number of retrieved oocytes and the fertilization rate were lower compared with patients with tubal infertility. Serum E(2) levels and expression of VEGF in patients with tubal infertility were statistically significantly higher than those in patients with endometriosis. Interleukin-6 gene expression did not differ between the groups. CONCLUSION(S): In severe endometriosis, lower VEGF gene expression in granulosa cells may adversely affect oocyte development and maturation.2002年10月, Fertility and sterility, 78(4) (4), 865 - 71, 英語, 国際誌研究論文（学術雑誌）
- Survivin gene expression in endometriosis.Survivin is a novel inhibitor of apoptosis and is expressed during fetal development and in cancer tissues, but its expression has not been reported in normal adult tissues or benign diseases. We investigated survivin gene and protein expression in a tumor-like benign disease, endometriosis, and correlated them with apoptosis and invasive phenotype of endometriotic tissues. Gene expression levels of survivin, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1 (MT1)-MMP in 63 pigmented or nonpigmented endometriotic tissues surgically obtained from 35 women with endometriosis were compared with those in normal eutopic endometrium obtained from 12 women without endometriosis. Survivin, MMP-2, MMP-9, and MT1-MMP mRNA expression levels in clinically aggressive pigmented lesions were significantly higher than those in normal eutopic endometrium, and survivin gene expression in pigmented lesions was also higher than that in nonpigmented lesions (P < 0.05). There was a close correlation between survivin and MMP-2, MMP-9, or MT1-MMP gene expression levels in 63 endometriotic tissues examined (P < 0.01). Apoptotic cells detected by the dUTP nick-end labeling were rare in 11 ovarian endometriotic tissues, which showed positive immunohistochemical expression for survivin and MMPs. Our findings suggest that up-regulation of survivin and MMPs may cooperatively contribute to survival and invasion of endometriosis.2002年07月, The Journal of clinical endocrinology and metabolism, 87(7) (7), 3452 - 9, 英語, 国際誌研究論文（学術雑誌）
- Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas.The correlation between vascular endothelial growth factor (VEGF)-C gene expression and in vitro invasive activity and matrix metalloproteinase (MMP)-2 or 9 gene expression and proteolytic activity in 11 cervical carcinoma cell lines, was investigated. Immunohistochemical expression of VEGF-C in 52 cervical carcinoma tissues was also correlated with tumor aggressiveness with respect to clinicopathologic features, tumor vascularity, MMP-2 expression and patient outcome. Expression of VEGF-C mRNA differed remarkably among the cell lines and there was a statistical correlation between VEGF-C gene expression and the number of invaded tumor cells (p = 0.0009) and MMP-2 gene expression and activity (p < 0.05). Anti-VEGF-C antibody inhibited the invasive and proteolytic activity of tumor cells in a concentration-dependent manner. VEGF-C or MMP-2 expression in clinical tissue samples was well correlated with depth of myometrial invasion, endometrial invasion, pelvic lymphnode metastasis and tumor vascularity (p < 0.05) and there was a close relation between VEGF-C and MMP-2 expression (p < 0.0001) in cervical carcinomas. Overall survival rates for 14 patients with strong VEGF-C staining tumors were lower than those for 38 patients with weak VEGF-C staining tumors (p = 0.0132) and VEGF-C tissue status emerged as an independent prognostic parameter (p = 0.0232). These results suggest that VEGF-C expression is closely related to invasion phenotype and affects the patient's survival in cervical carcinomas.2002年03月, International journal of cancer, 98(3) (3), 335 - 43, 英語, 国際誌研究論文（学術雑誌）
- 2025年, 画像診断, 45(2) (2)エキスパートをめざす産婦人科の画像診断 Case-based review 1 卵巣・卵管・腹膜 6 妊娠中に判明した非常に稀な卵巣腫瘍の一例
- 2025年, 産婦人科の進歩, 77(2) (2)子宮頸部から後腹膜に進展した子宮腺筋腫の1例
- 2025年, 産婦人科の進歩, 77(2) (2)7日間以上待機的に管理した癒着胎盤7症例の臨床経過
- 2025年, 産婦人科の進歩, 77(2) (2)Targeted maintenance tocolysisの試み
- 2025年, 産婦人科の進歩, 77(2) (2)子宮頸がんを契機に発症した肺高血圧症の1例
- 2025年, 産婦人科の進歩, 77(2) (2)妊娠初期に周期性四肢麻痺を発症した重症妊娠悪阻の1例
- 2025年, 日本女性医学学会雑誌, 32(3) (3)Rectovesical ligamentを有する重複子宮に対して腹腔鏡下子宮全摘術を施行した1例
- 2025年, 産婦人科の実際, 74(2) (2)産婦人科にかかわる医用技術の新たな進歩 II 手術支援ロボットの開発 わが国で進むロボット開発
- 2025年, 産科と婦人科, 92低侵襲手術の実際とコツ B.子宮 7 子宮体がん,子宮頸がん/腹腔鏡下手術・ロボット支援下手術
- 2025年, 超音波医学 Supplement, 52常位胎盤に対する癒着胎盤予測法確立に向けたリスク因子の抽出
- 2024年, 日本遺伝カウンセリング学会誌, 45(2) (2)NIPT判定保留後にステージIVの乳がんが判明した1例
- 2024年, 日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web), 66th腎移植後の婦人科がんリスクに関する後方視的研究
- 2024年, 日本婦人科腫瘍学会雑誌(Web), 42(2) (2)卵巣癌に対する内視鏡手術の現状と今後
- 2024年, 日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web), 66th妊娠中に診断された低異型度漿液性癌の1例
- 2024年, 産科と婦人科, 91(11) (11)再発・転移をきたした婦人科がんの治療-標準治療を超えた挑戦-【IV.外陰がん】11.腫瘍切除後の局所再発治療の現状-再手術か放射線治療の選択-
- 2024年, 産婦人科の進歩, 76(4) (4)神戸大学における子宮体癌IA期に対する内視鏡手術治療成績と再発例の検討
- 2024年, 産婦人科の進歩, 76(4) (4)前置胎盤帝王切開プロトコルを用いた専攻医への手術指導の効果
- 2024年, 産婦人科の進歩, 76(4) (4)hinotoriを用いたロボット支援下子宮体癌手術の手術成績
- 2024年, 産婦人科の進歩, 76(4) (4)後屈妊娠子宮嵌頓症の術前計画にMRI検査が有用であった1例
- 2024年, 日本婦人科ロボット手術学会プログラム・抄録集(Web), 12thhinotoriを用いたhybrid robotic assisted surgeryによる手術教育
- 2024年, 産婦人科の実際, 73(10) (10)多職種連携による婦人科がん治療の実践 リハビリテーションの婦人科がん治療における実際と連携
- 2024年, 日本産婦人科感染症学会学術講演会プログラム・抄録集, 40th (CD-ROM)梅毒合併妊娠に対するベンジルペニシリンベンザチン筋注製剤の使用経験
- 2024年, 日本癌学会学術総会抄録集(Web), 83rd腫瘍関連マクロファージとの相互作用によって誘導されるYKL40/integrinβ4経路は卵巣癌の進展に寄与する
- 2024年, 日本内視鏡外科学会総会(Web), 37th卵巣癌におけるロボット手術の可能性
- 2024年, 日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集, 42nd-32nd分娩前常位癒着胎盤予測法の確立に向けたリスク因子の抽出
- 2024年, 日本産科婦人科内視鏡学会学術講演会(Web), 64th国産手術支援ロボットhinotoriの治療成績と安全性
- 2024年, 日本産科婦人科内視鏡学会学術講演会(Web), 64th子宮悪性腫瘍を有する肥満症例に対するロボット支援手術の有用性
- 2024年, 日本産科婦人科内視鏡学会学術講演会(Web), 64th結節性硬化症を背景として腹腔鏡手術を行い,PEComaを含む子宮体癌と卵巣境界悪性腫瘍と診断された一例
- 2024年, 日本産科婦人科内視鏡学会学術講演会(Web), 64thCSTの概要と展望
- 2024年, 日本周産期・新生児医学会雑誌(Web), 60(3) (3)慢性胎盤早期剥離12例の妊娠予後および児予後の後方視的検討
- 2024年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 25th結節性硬化症を背景とした,PEComaを含む子宮体癌と卵巣境界悪性腫瘍と診断された一例
- 2024年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 25th術前MRIと術後病理の深部筋層浸潤診断が乖離し,腫瘍の急速増大がその原因と推定された子宮類内膜癌の1例
- 2024年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 25th帝王切開時の子宮切開位置決定に術前MRI検査が有用であった後屈妊娠子宮嵌頓症の一例
- 2024年, 日本女性骨盤底医学会プログラム・抄録集(CD-ROM), 26thRuge術後sigmoid neovagina prolapseの1例
- (一社)日本遺伝カウンセリング学会, 2023年06月, 日本遺伝カウンセリング学会誌, 44(2) (2), 156 - 156, 日本語
- 2023年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 24th妊娠中に判明した,非常に稀な悪性卵巣甲状腺腫(低分化癌)の1例
- 2023年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 24th腎細胞癌術後4年目に卵巣転移を来した1例
- 2023年, 映像情報Medical, 55(9) (9)婦人科疾患の診断・治療 卵巣癌の手術療法について
- 2023年, 日本婦人科ロボット手術学会プログラム・抄録集(Web), 11th国産手術支援ロボットhinotoriの臨床導入に向けて
- 2023年, 日本婦人科ロボット手術学会プログラム・抄録集(Web), 11th婦人科領域におけるhinotoriの幕開け
- 2022年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 23rd脂肪平滑筋腫との鑑別が困難であった,骨盤内血管筋脂肪腫の1例
- 「産婦人科の進歩」編集室, 2021年10月, 産婦人科の進歩, 73(4) (4), 500 - 500, 日本語胎児発育不全児の予後不良に関連する因子の検討
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P163 - P163, 日本語非初感染母体から出生した重篤な症候性先天性サイトメガロウイルス感染症児の一例
- (一社)日本周産期・新生児医学会, 2021年06月, 日本周産期・新生児医学会雑誌, 57(Suppl.) (Suppl.), P177 - P177, 日本語胎児治療と新生児治療の併用は先天性サイトメガロウイルス感染症児の予後を改善する
- 2021年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 42nd子宮内膜症を合併した子宮奇形に対し,腹腔鏡下手術を施行した2例
- 2021年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 42nd安全な婦人科鏡視下手術を行うために
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd妊娠中の画像診断で胎児共存奇胎と鑑別困難であった間葉系異形成胎盤の一例
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd50歳代女性に生じ術前診断が困難であった卵巣卵黄嚢腫瘍の一例
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd血管内へ浸潤再発したdeep soft tissue leiomyomaの1例
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd非交通性副角子宮に対し腹腔鏡下摘出術を施行し,腺筋症の診断に至った一例
- 2021年, 日本産科婦人科内視鏡学会学術講演会(Web), 61st経腟回収困難な巨大子宮筋腫に対する下腹部小開腹ハイブリッド手術の有用性
- 2021年, 日本産科婦人科内視鏡学会学術講演会(Web), 61stTrousseau症候群を契機に判明した原発不明癌に対して腹腔鏡下腫瘍生検術を施行した一例
- 2021年, 日本産科婦人科内視鏡学会学術講演会(Web), 61st完全型アンドロゲン不応症に対して腹腔鏡下性腺摘除術を施行した1例
- 2021年, 日本産科婦人科内視鏡学会学術講演会(Web), 61st定型化された腹腔鏡術式はロボット支援下子宮悪性腫瘍手術でも有用か
- 2021年, 日本産科婦人科内視鏡学会学術講演会(Web), 61st75歳以上の高齢者に対する鏡視下手術の検討
- 「産婦人科の進歩」編集室, 2019年10月, 産婦人科の進歩, 71(4) (4), 419 - 419, 日本語当院における子宮頸癌に対するベバシズマブの使用経験
- 金原出版(株), 2019年10月, 産婦人科の実際, 68(11) (11), 1359 - 1364, 日本語【迫り来る2020:新規保険収載へのロードマップと適正運用】外保連 腹腔鏡下傍大動脈リンパ節郭清術
- (株)メジカルビュー社, 2019年08月, 産婦人科手術, (30) (30), 162 - 162, 日本語当院での腹腔鏡下・ロボット支援下広汎子宮全摘術と開腹広汎子宮全摘術の比較検討
- (株)メジカルビュー社, 2019年08月, 産婦人科手術, (30) (30), 167 - 167, 日本語当院における腹腔鏡下子宮体癌手術の治療成績
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 451 - 451, 日本語卵巣癌初回治療におけるdose-dense TC療法とTC+bevacizumab併用療法の比較
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 457 - 457, 日本語卵巣癌・腹膜癌の術前化学療法時の診断において、腹腔鏡下生検と体腔液Cell block法の比較検討
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 476 - 476, 日本語子宮頸がんに対する放射線治療後不全骨折発症のリスクについての検討
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 525 - 525, 日本語トラベクテジンの長期投与が可能であった平滑筋肉腫の二例
- (公社)日本婦人科腫瘍学会, 2019年06月, 日本婦人科腫瘍学会雑誌, 37(3) (3), 530 - 530, 日本語妊孕性温存手術を施行したI期の卵巣上皮性境界悪性腫瘍の予後に関する検討
- 「産婦人科の進歩」編集室, 2019年05月, 産婦人科の進歩, 71(2) (2), 230 - 230, 日本語当院で経験した腹膜原発癌肉腫の2例
- 2019年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 40th肝臓内膜症の1例
- 2019年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th筋腫分娩様の所見を呈し,術前診断が困難であった子宮平滑筋肉腫の1例
- 2019年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th卵巣腫瘍と鑑別を要した肝細胞癌の骨盤内播種
- 2019年, 産婦人科の進歩, 71(1) (1)卵巣境界悪性腫瘍合併妊娠に対し腹腔鏡併用下に手術を施行した2例
- 2019年, 臨床婦人科産科, 73(12) (12)子宮体がんにおける腹腔鏡下傍大動脈リンパ節郭清
- 2019年, 日本産科婦人科学会雑誌, 71上皮性卵巣境界悪性腫瘍および卵巣癌118例におけるFDG-PET/CTのSUV max値の検討
- 2019年, 日本産科婦人科学会雑誌, 71プラチナ感受性再発卵巣癌に対するベバシズマブの有用性
- 2019年, 日本産科婦人科学会雑誌, 71子宮頸癌における18F-FDG PET/CTの有用性
- 2019年, 日本産科婦人科学会雑誌, 71当院での腹腔鏡下広汎子宮全摘出術と開腹広汎子宮全摘出術の排尿障害の検討
- 2019年, 日本産科婦人科学会雑誌, 71子宮内膜癌・子宮内膜異型増殖症に対するMPA療法の再投与について
- 2018年12月, 産婦人科の実際, 67(13号) (13号), 1735 - 1739, 日本語【外科解剖学から解き明かす広汎子宮全摘出術】 子宮がんにおけるセンチネルリンパ節記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年10月, ペリネイタルケア, 37(10号) (10号), 949 - 951, 日本語【妊婦のやせ・肥満 保健指導と分娩管理 リスクと予防法をエビデンスで解説】 やせ・肥満妊婦の分娩管理のポイント 現場で安心してお産に臨むには[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年10月, 産婦人科の実際, 67(11号) (11号), 1330 - 1337, 日本語【On Fleek 産婦人科手術】低侵襲手術 悪性 腹腔鏡下骨盤リンパ節郭清手術[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本生殖医学会, 2018年08月, 日本生殖医学会雑誌, 63(3) (3), 397 - 397, 日本語当院におけるMPA療法後の不妊治療についての検討
- 2018年07月, 医学のあゆみ, 266(1号) (1号), 57 - 62, 日本語【婦人科がん-研究・臨床の新展開】 子宮体癌 子宮体癌 手術療法のあらたな展開[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年05月, オペナーシング, (2018臨時増刊) (2018臨時増刊), 181 - 191, 日本語【産科・婦人科の手術看護パーフェクトマニュアル】(第2章)実践編 術式別の術中看護マニュアル 広汎子宮全摘出術(腹腔鏡)[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年05月, 日本医事新報, (4906号) (4906号), 31 - 33, 日本語【今、話題になっていること-婦人科編】 婦人科悪性腫瘍に対する鏡視下手術[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年03月, 産婦人科の実際, 67(3号) (3号), 335 - 340, 日本語臨床経験 45歳以上の超高齢妊娠における周産期予後についての検討[査読有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2018年03月, 日本臨床, 76(増刊2 婦人科がん) (増刊2 婦人科がん), 429 - 436, 日本語【婦人科がん(第2版)-最新の研究動向-】 子宮体がん 子宮体癌の治療 腹腔鏡下手術(傍大動脈リンパ節郭清を含めて)[招待有り]記事・総説・解説・論説等（学術雑誌）
- 2018年03月, 産婦人科の実際, 67(3号) (3号), 275 - 280, 日本語【エキスパートの内視鏡手術-コツとピットフォールI】 子宮体がん 腹腔鏡下子宮体がん手術[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (公社)日本産科婦人科学会, 2018年02月, 日本産科婦人科学会雑誌, 70(2) (2), 808 - 808, 日本語妊娠高血圧腎症妊婦における血管内皮機能異常と治療による改善効果の検討
- (公社)日本産科婦人科学会, 2018年02月, 日本産科婦人科学会雑誌, 70(2) (2), 940 - 940, 日本語当院におけるMPA療法後の妊娠についての検討
- 2018年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 39th子宮腺筋症に対するSequential療法の検討
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)卵巣境界悪性腫瘍・悪性腫瘍合併妊娠に対する腹腔鏡下手術の検討
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)高齢婦人科癌患者に対するweekly TC療法の安全性の検討
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)進行・再発子宮頸癌におけるBevacizumab併用療法の有用性について
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)中隔子宮を伴う不育症に対する子宮鏡下子宮中隔切除術の検討
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)子宮体癌の骨盤リンパ節転移の予測においてのPET-CTとセンチネルリンパ節生検の有用性の比較
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)70歳以上の高齢者における腹腔鏡下手術の安全性の検討
- 2018年, 日本産科婦人科学会雑誌, 70(2) (2)早期子宮頸癌患者に対するリンパ節転移の診断には,FDG PET/CTとセンチネルリンパ節生検術のどちらが有用か?
- 2018年, 産婦人科の進歩, 70(4) (4)当院におけるHBOC診療体制の現況
- 2018年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 19th子宮頸癌における18F-FDG PET-CTの有用性
- 2018年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 19th上皮性卵巣境界悪性腫瘍および卵巣癌におけるFDG-PET/CTのSUV max値の検討
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)凍結融解胚移植後,妊娠初期の大量腹水貯留を認め,診断に苦慮した進行胃癌の1例
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)胎児診断に至り,予後良好であったKlippel-Trenaunay-Weber症候群の2例
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)First trimesterにおける鼻骨欠損・鼻骨低形成の評価について
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)当院における出生前診断を受ける妊婦と家族の心理的支援システムの構築
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)産後に血栓性微小血管症をきたしたSLE合併妊娠の1例
- 2018年, 日本周産期・新生児医学会雑誌, 54(2) (2)当院におけるTrial of labor after cesarean delivery(TOLAC)の検討
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)当院における腹腔鏡下子宮体癌手術の治療成績
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)腹腔鏡手術を施行した妊娠合併未熟奇形腫の一例-当院の未熟奇形腫後方視的検討を加えて-
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)腹膜透析中の子宮内膜増殖症患者に対して腹腔鏡下子宮全摘出術を施行した一例
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)当院における腹腔鏡下広汎子宮全摘出術と開腹広汎子宮全摘出術の検討
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)腹腔鏡下手術を施行した卵巣境界悪性腫瘍の予後の検討
- 2018年, 日本癌治療学会学術集会(Web), 56thプラチナ感受性再発卵巣癌へのベバシズマブの有用性とプラチナフリー期間への関与
- 2018年, 日本内視鏡外科学会雑誌, 23(7 (CD-ROM)) (7 (CD-ROM))腹腔鏡下婦人科悪性腫瘍におけるセンチネルリンパ節ナビゲーション手術~ICGの有用性とこれから~
- 2018年, 日本内視鏡外科学会雑誌, 23(7 (CD-ROM)) (7 (CD-ROM))子宮体癌に対する腹腔鏡下手術適応拡大とさらなる低侵襲化を目指して
- 2018年, 産婦人科手術, (29) (29)腹式広汎子宮頸部摘出術後妊娠3例に対する帝王切開術
- 2018年, 産婦人科の実際, 67(3) (3)エキスパートの内視鏡手術-コツとピットフォール I 子宮体がん 腹腔鏡下子宮体がん手術
- 2018年, 産婦人科の進歩, 70(2) (2)境界悪性Brenner腫瘍の1例
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)当院での子宮内膜症性嚢胞に対する腹腔鏡下手術後の再発予防について
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)第一助手を育てれば,術者が育つ
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)非交通性副角子宮を伴う単角子宮に対し腹腔鏡補助下副角子宮摘出術を行った1例
- 2018年, 日本内視鏡外科学会雑誌, 23(7 (CD-ROM)) (7 (CD-ROM))当科で行っている腹腔鏡下神経温存広汎子宮全摘出術の実際
- 2018年, 日本産科婦人科内視鏡学会雑誌, 34(Supplement 1) (Supplement 1)再発悪性腫瘍に対して,腹腔鏡下手術で腫瘍摘出しえた2例
- 2018年, 産婦人科の進歩, 70(2) (2)13歳で手術を要した子宮筋腫の1例
- 2018年, 産婦人科手術, (29) (29)当科における妊娠中子宮頸部円錐切除症例の後方視的検討
- (一社)日本生殖医学会, 2017年10月, 日本生殖医学会雑誌, 62(4) (4), 412 - 412, 日本語卵管留水腫に対する腹腔鏡下卵管切除術(ストリップ法)前後の卵巣機能と術後妊娠率
- (一社)日本生殖医学会, 2017年10月, 日本生殖医学会雑誌, 62(4) (4), 469 - 469, 日本語卵巣機能低下不妊患者に対する経皮テストステロン剤の有用性の検討
- (一社)日本生殖医学会, 2017年10月, 日本生殖医学会雑誌, 62(4) (4), 478 - 478, 日本語当院における腹式広汎子宮頸部摘出術後の妊娠についての検討
- 医学書院, 2017年09月, 臨床婦人科産科, 71(9) (9), 836 - 845, 日本語血液凝固異常症 : 第Ⅻ因子・プロテインS欠乏症を含めて (今月の臨床 着床不全・流産をいかに防ぐか : PGS時代の不妊・不育症診療ストラテジー) -- (母体・子宮側因子による流産・不育症)
- (一社)日本産科婦人科内視鏡学会, 2017年08月, 日本産科婦人科内視鏡学会雑誌, 33(Suppl.I) (Suppl.I), 945 - 945, 日本語卵管留水腫に対する腹腔鏡下卵管切除術(ストリップ法)前後の卵巣機能と術後妊娠率
- 日本エンドメトリオーシス学会, 2017年07月, 日本エンドメトリオーシス学会会誌, 38, 104 - 104, 日本語卵巣予備能からみたチョコレート嚢胞への至適アプローチ AMHからみた子宮内膜症性嚢胞内壁焼灼術の有用性の検討
- (公社)日本婦人科腫瘍学会, 2017年06月, 日本婦人科腫瘍学会雑誌, 35(3) (3), 434 - 434, 日本語子宮体癌2018年版・子宮頸癌2017年版 (第2章)【初回治療】に関して
- メディカ出版, 2017年05月, Perinatal care = ペリネイタルケア, 36(5) (5), 486 - 489, 日本語3分でわかる 周産期医療キーワード2017(第15回)妊娠初期胎児超音波検査
- 医学書院, 2017年04月, 臨床婦人科産科, 71(3) (3), 336 - 343, 日本語腹腔鏡下手術 (今月の臨床 婦人科がん低侵襲治療の現状と展望) -- (子宮体がん)
- 日本婦人科腫瘍学会, 2017年04月, 日本婦人科腫瘍学会雑誌, 35(2) (2), 96 - 103, 日本語腹腔鏡下子宮体がん手術の普及に向けて (第58回日本婦人科腫瘍学会学術講演会記録) -- (シンポジウム 婦人科悪性腫瘍鏡視下手術の展望 : 教育,普及)
- (公社)日本産科婦人科学会, 2017年02月, 日本産科婦人科学会雑誌, 69(2) (2), 699 - 699, 日本語子宮内膜症性嚢胞内壁焼灼術におけるバイポーラ鉗子およびアルゴンプラズマコアギュレータの卵巣機能への影響
- (公社)日本産科婦人科学会, 2017年02月, 日本産科婦人科学会雑誌, 69(2) (2), 848 - 848, 日本語凍結融解胚移植における血中エストラジオール値と子宮内膜厚の関連についての検討
- (公社)日本産科婦人科学会, 2017年02月, 日本産科婦人科学会雑誌, 69(2) (2), 979 - 979, 日本語卵巣予備能評価として血清テストステロン基礎値は選択肢となりうるか
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)転移性卵巣腫瘍における外科的治療の有用性について
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)当科における再発卵巣癌に対するBevacizumab併用療法の使用経験
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)子宮内膜癌・子宮内膜異型増殖症に対するMPA療法の治療成績
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)生活習慣病からみた子宮体がんの臨床病理学的特徴
- 2017年, 産婦人科の進歩, 69(2) (2)卵巣悪性腫瘍合併妊娠の1例
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)腹腔鏡下子宮体癌手術において,腹腔内播種のため開腹移行例の検討
- 2017年, 産婦人科の進歩, 69(2) (2)娩出困難な稽留流産に対しTCRを施行した1例
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)子宮頸部癌肉腫の癌腫成分が神経内分泌腫瘍であった非常に稀な1例
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)子宮頸癌で卵巣温存はどこまで可能か
- 2017年, 臨床婦人科産科, 71(4) (4)産婦人科画像診断トレーニング この所見をどう読むか?悪性腫瘍 症例:卵巣がん 2)婦人科腫瘍におけるセンチネルリンパ節生検の可能性
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)2,347例のFirst trimester screeningにおける静脈管走行異常8例の検討
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)出生後に先天性気管閉鎖症と診断した1例
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)社会的ハイリスク妊産婦の検討大学病院における里親制度の支援について
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)社会的ハイリスク妊産婦の支援システム~精神疾患合併妊産褥婦を中心に~
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)原発性アルドステロン症合併妊娠の一例
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)前置胎盤のMRIにおける子宮下節の占有面積率と帝王切開時出血量の予測について
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)子宮頸癌における骨盤リンパ節転移の術前術中診断:PET-CTおよびsentinel node biopsyの有用性
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)子宮体がんに対する腹腔鏡下傍大動脈リンパ節郭清の有用性
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)子宮頸部初期病変(CIN)のHPV型と病変進展リスクについて
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)子宮頸がんに対する腹腔鏡下広汎子宮全摘出術の妥当性の検討
- 2017年, 産婦人科の進歩, 69(4) (4)当科で子宮頸部細胞診で「AGC」と判定された症例について
- 2017年, 日本女性医学学会雑誌, 25肥満子宮体がんに対する腹腔鏡下手術の検討
- 2017年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 18th婦人科悪性腫瘍でのリンパ節転移の診断における術前PET-CTの有用性
- 2017年, 日本臨床細胞学会雑誌(Web), 56神経内分泌腫瘍成分を伴う子宮頸部癌肉腫の1例
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(2) (2)嚢胞性子宮腺筋腫に対し子宮鏡下摘出術を施行した一例
- 2017年, 日本癌治療学会学術集会(Web), 55th局所進行子宮頸癌に対する術前動注化学療法
- 2017年, 日本癌治療学会学術集会(Web), 55th婦人科癌における高齢者へのweekly TC療法の安全性と有用性についての検討
- 2017年, 産婦人科手術, (28) (28)ハイリスク症例への対応/肥満症例への対応-腹腔鏡下手術-肥満子宮体がんに対する腹腔鏡下手術の安全性評価の検討
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)当科における婦人科悪性腫瘍術後のリンパ浮腫発症リスク因子
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))子宮内避妊具の抜去における子宮鏡の有用性の検討
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))腹腔鏡手術後に臍部周囲より動脈性に出血し緊急再手術となった1症例
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))センチネルリンパ節マッピングによるリンパ流を意識した骨盤リンパ節郭清術
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))進行卵巣癌,腹膜癌に対して診断目的で行った腹腔鏡下手術の検討
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))当院での大型子宮に対する腹腔鏡下子宮全摘出術の工夫
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))Mayer-Rokitansky-Kuster-Hauser(MRKH)症候群に対して腹腔鏡補助下McIndoe法を施行した3例
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))術前に診断が困難であった腹腔内播種病巣のため,腹腔鏡手術から開腹術移行症例の検討
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)難治性卵巣癌モデルマウスに対するCD24を標的とした高分子ミセルを用いた新規治療
- 2017年, 日本周産期・新生児医学会雑誌, 53(2) (2)当院におけるPPHに対する子宮動脈塞栓術とBakriバルーン使用例の検討
- 2017年, 日本臨床細胞学会雑誌(Web), 56子宮体がんに対する腹腔鏡下手術における腹水細胞診
- 2017年, 日本産科婦人科内視鏡学会雑誌, 33(Supplement 1 (Web)) (Supplement 1 (Web))卵巣境界悪性腫瘍に対する腹腔鏡下手術の検討
- 2017年, 日本内視鏡外科学会雑誌, 22(7 (CD-ROM)) (7 (CD-ROM))腹腔鏡下婦人科悪性腫瘍手術における安全な視野展開と操作のコツ
- 2017年, 日本臨床細胞学会雑誌(Web), 56鎖骨上窩リンパ節に再発を来した卵巣境界悪性腫瘍の1例
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)子宮頸癌および子宮体癌におけるPET-CTとセンチネルリンパ節生検の有用性について
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)転移性卵巣腫瘍における臨床的特徴と予後不良因子について
- 2017年, 日本婦人科腫瘍学会雑誌, 35(3) (3)術前化学療法施行後の進行卵巣癌症例に対する後腹膜リンパ節郭清の意義
- 2017年, 日本産科婦人科学会雑誌, 69(2) (2)Seromucinous borderline tumor(SMBT)の術前診断の精度について
- 2017年, 婦人科がんバイオマーカー研究会学術集会プログラム・抄録集, 5th子宮内膜癌における選択的サイクリン依存性キナーゼ(CDK)4/6阻害剤palbociclib(PD-0332991)の有効性
- (一社)日本生殖医学会, 2016年10月, 日本生殖医学会雑誌, 61(4) (4), 409 - 409, 日本語子宮内膜症性嚢胞蒸散術後の卵巣抗ミュラー管ホルモン値、卵巣血流は術後再発予測因子となり得るか?
- (一社)日本生殖医学会, 2016年10月, 日本生殖医学会雑誌, 61(4) (4), 465 - 465, 日本語凍結融解胚移植における内膜の厚さと血中エストラジオール値測定の臨床的意義について
- 2016年10月, PLACENTA, 46, 104 - 104, 英語RECOMBINANT HUMAN THROMBOMODULIN IMPROVES MATERNAL AND FETAL CONDITIONS IN MOUSE MODEL OF RECURRENT MISCARRIAGE研究発表ペーパー・要旨（国際会議）
- (一社)日本IVF学会, 2016年09月, 日本IVF学会誌, 19(2) (2), 77 - 77, 日本語原因不明不妊とFOXO遺伝子との関係について
- (一社)日本産科婦人科内視鏡学会, 2016年08月, 日本産科婦人科内視鏡学会雑誌, 32(Suppl.I) (Suppl.I), 111 - 111, 日本語
- (一社)日本産科婦人科内視鏡学会, 2016年08月, 日本産科婦人科内視鏡学会雑誌, 32(Suppl.I) (Suppl.I), 116 - 116, 日本語
- 医学書院, 2016年05月, 臨床婦人科産科, 70(5) (5), 433 - 438, 日本語婦人科腫瘍におけるセンチネルリンパ節生検の可能性
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 930 - 930, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 931 - 931, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 940 - 940, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 790 - 790, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 942 - 942, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 619 - 619, 日本語
- (公社)日本産科婦人科学会, 2016年02月, 日本産科婦人科学会雑誌, 68(2) (2), 793 - 793, 日本語
- 金原出版, 2016年02月, 産婦人科の実際, 65(2) (2), 125 - 131, 日本語腹腔鏡下子宮体がん手術の適応と限界 (特集 婦人科腹腔鏡手術の適応と限界を考える)
- 2016年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 37th子宮内膜症性嚢胞に対する手術療法の術前後の卵巣予備能,卵巣血流と再発の検討
- 2016年, 産婦人科の進歩, 68(2) (2)扁平上皮癌の成分を有する卵巣癌肉腫の1例
- 2016年, 産婦人科の進歩, 68(2) (2)術前に卵巣腫瘍と鑑別診断が困難であった末梢神経鞘腫の1例
- 2016年, 産婦人科の進歩, 68(2) (2)直腸および子宮体部に浸潤したダグラス窩原発扁平上皮癌の1例
- 2016年, 産婦人科の進歩, 68(3) (3)当科における再発卵巣癌に対するベバシズマブ併用化学療法の検討
- 2016年, 日本臨床細胞学会雑誌(Web), 55癌性腹膜炎との鑑別を要した悪性腹膜中皮腫の一例
- 2016年, 日本臨床細胞学会雑誌(Web), 55進行卵巣癌・腹膜癌のNAC症例における,腹水細胞診と腹腔鏡下生検の有用性について
- 2016年, 日本臨床細胞学会雑誌(Web), 55子宮癌における捺印細胞診を用いたセンチネルリンパ節術中迅速診断
- 2016年, 日本周産期・新生児医学会雑誌, 52(2) (2)当院における社会的リスク妊婦の検討
- 2016年, 日本周産期・新生児医学会雑誌, 52(2) (2)妊娠初期胎児1,521例における三尖弁逆流の意義について
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)診断目的で行った腹腔鏡下生検術の検討
- 2016年, 日本臨床細胞学会雑誌(Web), 55捺印細胞診で推定し得た卵巣癌肉腫の1例
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)卵巣成熟嚢胞性奇形腫の悪性転化により明細胞癌を発症した一例
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)腹腔鏡下手術により,術中および術後に卵巣境界悪性腫瘍と診断された症例の検討
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)子宮頸癌術後再発リスク群に対する術後補助化学療法の有用性についての検討
- 2016年, 日本周産期・新生児医学会雑誌, 52(2) (2)当院における産科危機的出血の救急受け入れ体制の試み
- 2016年, 日本臨床細胞学会雑誌(Web), 55子宮頸部初期病変の細胞診・組織診不一致症例の解析
- 2016年, 日本癌治療学会学術集会(Web), 54th当院でベバシズマブを投与した再発卵巣癌,卵管癌,腹膜癌症例の安全性と有効性の検討
- 2016年, 日本癌治療学会学術集会(Web), 54th子宮体癌におけるセンチネルリンパ節生検
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)腹腔鏡下子宮体癌手術における合併症とその対応
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)腹腔鏡下に診断,治療し得た腹膜妊娠の一例
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)「婦人科内視鏡手術における安全担保」ガイドラインからみた安全担保
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)子宮筋腫に対する筋腫核出術を併用した腹腔鏡下単純子宮全摘出術の検討
- 2016年, 日本内視鏡外科学会雑誌, 21(7 (CD-ROM)) (7 (CD-ROM))子宮頸がんに対する腹腔鏡下神経温存根治的子宮全摘出術
- 2016年, 日本内視鏡外科学会雑誌, 21(7 (CD-ROM)) (7 (CD-ROM))子宮癌のセンチネルリンパ節生検
- 2016年, 婦人科がんバイオマーカー研究会学術集会プログラム・抄録集, 4th子宮頸癌におけるCD24の機能解析
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)腹腔鏡下手術中に膀胱鏡検査を行うことで尿路損傷を把握できた1症例
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)子宮癌におけるセンチネルリンパ節生検
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)子宮頸部初期病変円錐切除後の再発症例の後方視的検討
- 2016年, 産婦人科手術, (27) (27)再発卵巣境界悪性腫瘍に対し骨盤内除臓術を施行した1例
- 2016年, 日本癌治療学会学術集会(Web), 54th子宮頸部初期病変円錐切除後の再発症例の後方視的検討
- 2016年, 日本婦人科腫瘍学会雑誌, 34(3) (3)腹腔鏡下子宮体がん手術の普及に向けて
- 2016年, 日本周産期・新生児医学会雑誌, 52(2) (2)子宮筋腫摘出後妊娠における周産期予後の検討
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)嚢胞性子宮腺筋腫に対し子宮鏡下摘出術を施行した一例
- 2016年, 日本産科婦人科内視鏡学会雑誌, 32(Supplement 1) (Supplement 1)抗NMDA受容体脳炎を合併し,緊急腹腔鏡下手術を行った卵巣未熟奇形腫の1例
- 2016年, 日本内視鏡外科学会雑誌, 21(7 (CD-ROM)) (7 (CD-ROM))適応と限界を考慮した腹腔鏡下子宮体がん手術術式
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 698 - 698, 日本語P2-31-10 子宮頸癌4B期の孤立性リンパ節転移は層別化因子となりうるか(Group31 子宮頸癌・治療2・合併症・予後因子,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 700 - 700, 日本語P2-32-4 進行,再発子宮頸癌に対するシスプラチン・イリノテカン併用療法の有用性に関する検討(Group32 子宮頸癌・治療3・化学療法・再建,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 896 - 896, 日本語P3-27-3 当院における腹腔鏡下子宮体癌手術の治療成績(Group92 子宮体部腫瘍・腹腔鏡手術1,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 867 - 867, 日本語P3-16-7 進行卵巣癌での腹腔内生検における細胞表面マーカーCD24の発現の意義(Group 81 卵巣腫瘍・バイオマーカー,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 596 - 596, 日本語MW3-1 子宮内膜癌におけるpalbociclib(PD-0332991)の機能解析(ミニワークショップ3 子宮体部腫瘍,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- 日本産科婦人科学会, 2016年, 日本産科婦人科學會雜誌, 68(2) (2), 632 - 632, 日本語P2-5-8 子宮内膜癌に対するforetinibの抗腫瘍効果についての検討(Group5 子宮体部腫瘍・基礎,一般演題,公益社団法人日本産科婦人科学会第68回学術講演会)
- メディカ出版, 2016年01月, ペリネイタルケア, 35(1) (1), 61 - 71, 日本語出生前診断におけるエコーの役割 (特集 週数別 エコーのみかたコツとワザ : いつ診る?どこ診る?どう伝える?)
- 医学書院, 2015年11月, 臨床婦人科産科, 69(11) (11), 1066 - 1072, 日本語卵巣癌 (今月の臨床 婦人科腹腔鏡手術の進歩と"落とし穴") -- (腹腔鏡手術のピットフォール)
- 診断と治療社, 2015年11月, 産科と婦人科, 82(11) (11), 1242 - 1247, 日本語子宮体癌に対する腹腔鏡下手術 (特集 婦人科腹腔鏡手術の最前線)
- 医学書院, 2015年09月, 臨床婦人科産科, 69(9) (9), 820 - 825, 日本語微小浸潤癌への円錐切除術 (今月の臨床 がん妊孕性温存治療の適応と注意点 : 腫瘍学と生殖医学の接点) -- (婦人科腫瘍学 : 子宮頸癌)
- 「産婦人科の進歩」編集室, 2015年05月, 産婦人科の進歩, 67(2) (2), 212 - 212, 日本語
- 金原出版, 2015年05月, 産婦人科の実際, 64(5) (5), 635 - 641, 日本語子宮内膜癌における腹腔鏡下手術 (特集 子宮内膜癌治療の最前線) -- (子宮内膜癌に対する手術療法)
- 医学書院, 2015年04月, 臨床婦人科産科, 69(3) (3), 313 - 319, 日本語早産に対する黄体ホルモン療法の展望 (今月の臨床 早産の予知・予防の新たな展開) -- (早産の予防)
- (公社)日本産科婦人科学会, 2015年02月, 日本産科婦人科学会雑誌, 67(2) (2), 752 - 752, 日本語
- (公社)日本産科婦人科学会, 2015年02月, 日本産科婦人科学会雑誌, 67(2) (2), 898 - 898, 日本語
- (公社)日本産科婦人科学会, 2015年02月, 日本産科婦人科学会雑誌, 67(2) (2), 731 - 731, 日本語
- 2015年, 日本エンドメトリオーシス学会学術講演会プログラム・抄録集, 36th卵巣予備能を考慮した子宮内膜症性嚢胞に対する手術療法の選択
- 2015年, 日本産科婦人科学会雑誌, 67(2) (2)当院における顆粒膜細胞腫症例の検討
- 2015年, 産婦人科の進歩, 67(2) (2)腹腔鏡下生検にて診断した原発不明血管肉腫の1例
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)腹腔鏡下広汎子宮全摘術
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)腹腔鏡下生検にて診断した原発不明血管肉腫の1例
- 2015年, 日本婦人科腫瘍学会雑誌, 33(3) (3)子宮体がん 早期例の腹腔鏡から進行例にかけての手術の実際
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)術前早期子宮体癌に対し腹腔鏡下準広汎子宮全摘術を施行することで,傍腟結合織への転移の診断が可能であった1例
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)卵管間質部妊娠に対し,腹腔鏡下手術が有用であった3例
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)モルセレーターを使用しない腹腔鏡下子宮筋腫核出術
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)保険適応となった腹腔鏡下子宮体がん手術の現状と今後
- 2015年, 日本婦人科腫瘍学会雑誌, 33(3) (3)子宮体癌臍転移Sister Mary Joseph’s noduleの2例
- 2015年, 日本婦人科腫瘍学会雑誌, 33(3) (3)術前動注化学療法を施行した局所進行子宮頸癌に対する術後補助療法に関する検討
- 2015年, 日本臨床細胞学会雑誌(Web), 54内膜細胞診が診断に有用であったタモキシフェン内服後に子宮癌肉腫を発症した2例
- 2015年, 日本臨床細胞学会雑誌(Web), 54分葉状内頸部腺過形成(LEGH)との共存がみられた子宮頸部腺癌の1例
- 2015年, 産婦人科の進歩, 67(4) (4)当院における再発卵巣癌に対するアバスチン併用化学療法の検討
- 2015年, 産婦人科手術, (26) (26)骨盤リンパ節郭清における陰部大腿皮神経損傷
- 2015年, 日本癌治療学会学術集会(Web), 53rd予後不良な子宮体癌に関する組織型からの検討
- 2015年, 日本癌治療学会学術集会(Web), 53rd再発,進行子宮頸癌に対するシスプラチン・イリノテカン併用療法に関する検討
- 2015年, 日本婦人科腫瘍学会雑誌, 33(3) (3)子宮癌に対するセンチネルリンパ節生検
- 2015年, 日本臨床細胞学会雑誌(Web), 54子宮癌のセンチネルリンパ節術中診断における迅速捺印細胞診の有用性
- 2015年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 16th子宮体癌の筋層浸潤評価における,術前MRI検査と術中迅速病理診断の有用性
- 2015年, 日本産科婦人科内視鏡学会雑誌, 31(Supplement 1) (Supplement 1)腹腔鏡下手術により診断が可能であった子宮奇形の1例
- 2015年, 日本抗加齢医学会総会プログラム・抄録集, 15th内膜症における低テストステロン環境の卵胞顆粒膜細胞に対する影響
- 2015年, 産婦人科手術, (26) (26)子宮頸がんに対する腹腔鏡下広汎子宮全摘出術
- 2015年, 産婦人科手術, (26) (26)早期子宮体癌に対する腹腔鏡下手術についての検討
- 2015年, 産婦人科の進歩, 67(2) (2)遺残子宮内膜症から発生したと考えられる癌肉腫の1例
- 2015年, 日本内視鏡外科学会雑誌, 20(7 (CD-ROM)) (7 (CD-ROM))先進医療に基づく子宮頸癌に対する腹腔鏡下広汎子宮全摘術の導入
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 884 - 884, 日本語P3-27-1 卵巣予備能を考慮した子宮内膜症性嚢胞に対する手術療法の選択(Group129 子宮内膜症1 薬物療法,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 909 - 909, 日本語P3-35-10 当院における19年間のTrial of labor after cesarean deliveryの管理について(Group137 子宮破裂 TOLAC,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 561 - 561, 日本語P1-12-1 子宮頸部筋腫に対する腹腔鏡下子宮全摘術(Group12 腹腔鏡下手術1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 933 - 933, 日本語P3-43-6 抗リン脂質抗体陽性妊婦13例の検討(Group145 合併症妊娠8,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 931 - 931, 日本語P3-43-2 当院における膠原病合併妊娠の周産期予後の検討(Group145 合併症妊娠8,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 936 - 936, 日本語P3-44-9 帝王切開術後におけるVTE発症予防について : 低分子ヘパリン(エノキサパリン)の導入(Group146 合併症妊娠9,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 734 - 734, 日本語P2-33-5 体外受精治療における化学的流産周期の予測・早期診断(Group 74 生殖補助医療3 妊娠予後,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 764 - 764, 日本語P2-44-7 有経子宮頸癌女性に対する治療の骨密度への影響とエストロゲン補充による改善効果(Group 85 更年期2 治療,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 839 - 839, 日本語P3-9-4 子宮内膜癌・子宮内膜異型増殖症に対するMPA療法後の再発率について(Group 111 子宮体部腫瘍 治療3 ホルモン療法,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 842 - 842, 日本語P3-10-6 肥満子宮体がんに対しては腹腔鏡下手術と開腹手術のどちらがよいか?(Group 112 子宮体部腫瘍 治療4 腹腔鏡手術,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 826 - 826, 日本語P3-4-1 術前化学療法施行した子宮頸癌に対する術後補助療法に関する検討(Group 106 子宮頸部腫瘍 治療1,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 527 - 527, 日本語NW-18-2 手術適応外とされる18trisomy症候群に合併した心室中隔欠損症に対する外科治療介入の臨床像(ミニワークショップ18 胎児異常の諸問題,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 669 - 669, 日本語P2-8-2 子宮内膜癌における卵巣静脈中エストラジオール濃度(Group49 子宮体部腫瘍 症例検討,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 699 - 699, 日本語P2-18-8 当院における穎粒膜細胞腫症例の検討(Group 59 卵巣腫瘍 症例検討1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 856 - 856, 日本語P3-15-9 術前化学療法によりpathological CRを得た進行卵巣癌症例7例の後方視的検討(Group 117 卵巣腫瘍 診断2,一般演題,第67回学術講演会)
- 日本産科婦人科学会, 2015年, 日本産科婦人科學會雜誌, 67(2) (2), 874 - 874, 日本語P3-23-4 腹腔鏡と子宮鏡による同時手術を必要とした症例の検討(Group 125 子宮鏡,一般演題,第67回学術講演会)
- (一社)日本生殖医学会, 2014年10月, 日本生殖医学会雑誌, 59(4) (4), 375 - 375, 日本語血清テストステロン値は卵巣予備能の指標として有用である
- (一社)日本生殖医学会, 2014年10月, 日本生殖医学会雑誌, 59(4) (4), 436 - 436, 日本語子宮内膜症における低テストステロン環境の顆粒膜細胞に対する影響の検討
- 医学書院, 2014年07月, 臨床婦人科産科, 68(7) (7), 628 - 634, 日本語腹腔鏡下骨盤リンパ節郭清手術 (今月の臨床 あなたにもできる 最先端の婦人科手術)
- (公社)日本産科婦人科学会, 2014年02月, 日本産科婦人科学会雑誌, 66(2) (2), 845 - 845, 日本語
- 2014年, 日本ワクチン学会学術集会プログラム・抄録集, 18th子宮頸がん予防ワクチンの副反応報道・厚労省積極的勧奨一時中止後の再普及に向けて~インターネット調査から見えてきたもの~
- 2014年, 産婦人科の進歩, 66(2) (2)閉経後Sertoli細胞腫の1例
- 2014年, 日本産科婦人科内視鏡学会雑誌, 30(Supplement 1) (Supplement 1)腹腔鏡下子宮全摘術における術式の工夫~筋腫核出術併用の有効性~
- 2014年, 日本臨床細胞学会雑誌, 53子宮頸部明細胞腺癌の1例
- 2014年, 日本婦人科腫瘍学会雑誌, 32(3) (3)子宮内膜癌は閉経後においても卵巣の影響をうけているか
- 2014年, 日本産科婦人科内視鏡学会雑誌, 30(Supplement 1) (Supplement 1)腹腔鏡下神経温存広汎子宮全摘術
- 2014年, 日本臨床細胞学会雑誌, 53閉経後Sertoli細胞腫の1例
- 2014年, 日本婦人科腫瘍学会雑誌, 32(3) (3)子宮頸癌術後再発リスク群に対する術後補助化学療法の検討
- 2014年, 産婦人科手術, (25) (25)産科領域手術の進歩/妊娠中の腹腔鏡下手術 妊娠中の卵巣腫瘍に対する腹腔鏡下手術
- 2014年, 日本産科婦人科内視鏡学会雑誌, 30(Supplement 1) (Supplement 1)子宮体がんに対する腹腔鏡下手術の現状と今後の展開
- 2014年, 日本婦人科腫瘍学会雑誌, 32(3) (3)子宮体癌の病理学的悪性度から見た拡散強調画像の有用性の検討
- 2014年, 産婦人科の進歩, 66(3) (3)妊娠中の子宮頸部円錐切除術の留置点について
- 2014年, 日本癌治療学会学術集会(CD-ROM), 52nd所進行子宮頸癌に対するfour-lumen double-balloon catheterを用いた術前動注化学療法
- 2014年, 日本抗加齢医学会総会プログラム・抄録集, 14th抗癌剤誘発性の早発卵巣機能不全に対するテストステロンの予防効果-基礎的検討-
- 2014年, 日本癌治療学会学術集会(CD-ROM), 52nd子宮体がんにおけるセンチネルリンパ節生検
- 2014年, 日本婦人科腫瘍学会雑誌, 32(3) (3)子宮頚部横紋筋肉腫の一例
- 2014年, 日本産科婦人科栄養・代謝研究会誌, 20(1) (1)性腺ホルモン供給源としての閉経後卵巣~閉経女性の健康に与える光と影~
- 2014年, 日本内視鏡外科学会雑誌, 19(7) (7)早期子宮体癌に対する腹腔鏡下準広汎子宮全摘術
- 2014年, 日本産科婦人科内視鏡学会雑誌, 30(Supplement 1) (Supplement 1)当科における子宮体癌腹腔鏡下手術とその工夫
- 2014年, 日本臨床細胞学会雑誌, 53子宮頸部横紋筋肉腫(ブドウ状肉腫)の一例
- 2014年, 産婦人科手術, (25) (25)早期子宮体癌に対する腹腔鏡下手術
- 2014年, 日本産科婦人科内視鏡学会雑誌, 30(Supplement 1) (Supplement 1)卵巣線維腫に対する腹腔鏡下手術の有用性について
- 2014年, 日本臨床細胞学会雑誌, 53子宮体部類内膜腺癌術後に発生した腟癌肉腫の1例
- 2014年, 産婦人科の進歩, 66(2) (2)右房内に伸展した血管内子宮筋腫の1例
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 732 - 732, 日本語P2-51-7 子宮頸癌術後再発リスク群に対する術後補助化学療法の検討(Group 89 子宮頸部腫瘍・治療1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 740 - 740, 日本語P2-54-7 卵巣癌におけるCD24の発現意義と機能解析について(Group 92 卵巣腫瘍・基礎3,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 455 - 455, 日本語MW-15-1 ヒト子宮筋腫組織皮下移植マウスモデルにおける腫瘍発育の多様性に関する検討(ミニワークショップ15 子宮筋腫・基礎と臨床,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 495 - 495, 日本語P1-9-6 Uterine smooth muscle tumor of uncertain malignant potential(STUMP)7例の臨床病理学的検討(Group 9 子宮体部腫瘍・症例2,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 502 - 502, 日本語P1-11-7 妊娠中のCIN症例の管理について(Group 11 CIN・その他・診断・治療1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 520 - 520, 日本語P1-19-4 子宮頸癌および子宮体癌に対するセンチネルリンパ節生検(Group 19 悪性腫瘍全般・診断2,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 371 - 371, 日本語1. 妊娠中の婦人科良性・悪性腫瘍 : 検診,診断,治療(クリニカルカンファレンス3-Subspecialtyを越えて(周産期・腫瘍)-,生涯研修プログラム,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 341 - 342, 日本語3. 難治性卵巣癌の浸潤・転移に関わる分子をターゲットとした新規治療法の開発(難治性卵巣癌の克服を目指して,シンポジウム2(腫瘍),公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 610 - 610, 日本語P2-10-3 婦人科悪性腫瘍手術周術期管理におけるCK値の意義(Group48 悪性腫瘍全般・治療3,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 602 - 602, 日本語P2-7-3 腹腔鏡下子宮全摘術における術式の工夫 : 筋腫核出術併用の有効性(Group45 腹腔鏡下手術2,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 605 - 605, 日本語P2-8-2 婦人科悪性腫瘍に対するTC療法が及ぼす動脈硬化への影響とその予防について(Group46 悪性腫瘍全般・治療1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 690 - 690, 日本語P2-39-5 習慣性流産および胎児発育不全におけるAnnexinA5の発現の免疫組織学的検討(Group 77 不育症・流産,一般演題,第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 838 - 838, 日本語P3-27-5 子宮内膜症性嚢胞の内壁焼灼術は卵巣予備能の低下を回避できるか?(Group 124 子宮内膜症・臨床3,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 905 - 905, 日本語P3-52-9 初回完全摘出手術が困難である進行卵巣癌に対する腹腔鏡下手術の検討(Group 149 卵巣腫瘍・治療4,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 898 - 898, 日本語P3-50-4 卵巣粘液性腫瘍の術前正診率の向上を目指して(Group 147 卵巣腫瘍・診断1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 483 - 483, 日本語P1-5-7 子宮内膜症におけるドパミンD1,D2受容体の検討(Group 5 子宮内膜症・基礎1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(2) (2), 474 - 474, 日本語P1-3-3 不妊患者における子宮鏡下切除術の有用性(Group 3 不妊症1,一般演題,公益社団法人日本産科婦人科学会第66回学術講演会)
- 日本産科婦人科学会, 2014年, 日本産科婦人科學會雜誌, 66(9) (9), 2089 - 2093, 日本語1. 妊娠中の婦人科良性腫瘍・悪性腫瘍 : 検診,診断,治療(クリニカルカンファレンス3-Subspecialtyを越えて(周産期・腫瘍)-,生涯研修プログラム,第66回日本産科婦人科学会学術講演会講演要旨)
- 金原出版, 2013年09月, 産婦人科の実際, 62(9) (9), 1195 - 1200, 日本語子宮体がんとSERM (特集 ホルモン依存性悪性腫瘍 : 特徴と対処を考える) -- (子宮体がん)
- 医学書院, 2013年05月, 臨床婦人科産科, 67(5) (5), 491 - 496, 日本語子宮体がんに対する腹腔鏡下手術 (今月の臨床 子宮体がん診療アップデート) -- (治療のトピックス)
- 2013年, 日本臨床細胞学会雑誌, 52腹腔鏡下生検で腹水細胞診陽性であった虫垂癌の一例
- 2013年, 日本産科婦人科内視鏡学会雑誌, 29(Supplement 1) (Supplement 1)茎捻転による急性腹症を伴った腫瘍内容液が13kgの巨大卵巣嚢腫の一例
- 2013年, 日本癌治療学会学術集会(CD-ROM), 51st婦人科癌における中等度催吐性化学療法TC療法に対する制吐剤3剤併用療法の効果検討
- 2013年, 日本癌治療学会学術集会(CD-ROM), 51st若年子宮内膜癌・子宮内膜異型増殖症に対するMPA療法の治療成績
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)MRIで卵巣粘液性境界悪性腫瘍は診断できるか?
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)婦人科癌における中等度催吐性化学療法TC療法に対する制吐剤3剤併用療法の効果検討
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)若年子宮内膜癌・子宮内膜異型増殖症に対するMPA療法の治療成績
- 2013年, 日本臨床細胞学会雑誌, 52卵巣小細胞癌の1例
- 2013年, 産婦人科の実際, 62(12) (12)プロメテウス 婦人科がん最新医療 子宮体がん 4.子宮体がんの手術療法(1)腹腔鏡下手術
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)早期子宮体癌に対する腹腔鏡下手術
- 2013年, 産婦人科の進歩, 65(4) (4)妊娠中の子宮頸部円錐切除術の留置点について
- 2013年, 日本癌治療学会学術集会(CD-ROM), 51st当院における転移性卵巣腫瘍切除症例の検討
- 2013年, 産婦人科の進歩, 65(2) (2)タモキシフェン内服後に発症した子宮癌肉腫の1例
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)白金製剤耐性卵巣癌におけるAktをターゲットとした分子標的薬としてのGemcitabineの機能解析
- 2013年, 産婦人科手術, (24) (24)先進医療に基づく腹腔鏡下子宮体癌手術
- 2013年, 日本婦人科腫瘍学会雑誌, 31(3) (3)抗癌剤が及ぼす動脈硬化進展メカニズムの解析とフィブラートによる予防効果に関する検討
- 2013年, 日本産科婦人科内視鏡学会雑誌, 29(Supplement 1) (Supplement 1)先進医療制度で始まった子宮体がんに対する腹腔鏡下手術
- 2013年, 日本癌治療学会学術集会(CD-ROM), 51st子宮頸癌におけるCD24の発現意義
- 金原出版, 2013年01月, 産婦人科の実際, 62(1) (1), 45 - 50, 日本語子宮体がんに対する腹腔鏡下手術 (特集 婦人科がん手術の最前線) -- (子宮体がん)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 533 - 533, 日本語P1-1-7 婦人科悪性腫瘍に対する抗癌剤治療が動脈硬化へ及ぼす影響とフィブラートの予防効果について(Group 1 悪性腫瘍全般・基礎,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 861 - 861, 日本語P3-2-5 卵巣癌における膜型エストロゲン受容体GPR30を介した転移メカニズムの解析(Group 107 卵巣腫瘍・基礎2,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 871 - 871, 日本語P3-5-10 白金製剤耐性卵巣癌におけるAktをターゲットとした分子標的薬としてのGemcitabineの機能解析(Group 110 卵巣腫瘍・基礎5,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 866 - 866, 日本語P3-4-3 卵巣癌におけるEMT現象の意義(Group 109 卵巣腫瘍・基礎4,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 861 - 861, 日本語P3-2-4 上皮間葉転換(EMT)を介した浸潤・転移の制御を目指して : CD24の機能解析(Group 107 卵巣腫瘍・基礎2,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 877 - 877, 日本語P3-8-1 卵巣腫瘍合併妊娠に対する妊娠時腹腔鏡下手術の検討(Group 113 卵巣腫瘍・腹腔鏡手術,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 958 - 958, 日本語P3-35-1 子宮内膜症および卵巣嚢腫に対する各種細径腹腔鏡下手術の有用性(Group 140 腹腔鏡下手術3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 962 - 962, 日本語P3-36-7 MRIで卵巣粘液性境界悪性腫瘍は診断できるか?(Group 141 卵巣腫瘍・診断,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 699 - 699, 日本語P2-2-6 CINから初期子宮頸癌合併妊娠の管理について(Group 54 CIN・その他・診断・治療2,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 588 - 588, 日本語P1-22-3 早期子宮体癌に対する腹腔鏡手術(Group 22 子宮体部腫瘍・治療5,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本産科婦人科学会, 2013年, 日本産科婦人科學會雜誌, 65(2) (2), 607 - 607, 日本語P1-29-4 当科における子宮内膜症に対する腹腔鏡下手術成績(Group 29 子宮内膜症・臨床4,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)
- 日本生殖免疫学会, 2012年11月, Reproductive Immunology and Biology, 27(1-2) (1-2), 61 - 61, 英語生殖免疫の立場から不妊症、不育症を議論する 子宮内膜症症例の黄体化顆粒膜細胞におけるアンドロゲン受容体とFSH受容体発現のエピジェネティック変化の検討(Expression and epigenetic change of the AR and FSHR genes in the granulosa cells of endometriosis patients)
- (一社)日本癌治療学会, 2012年10月, 日本癌治療学会誌, 47(3) (3), 1783 - 1783, 日本語動注化学療後の神経温存広汎子宮全摘術における排尿機能の評価
- (公社)日本産科婦人科学会, 2012年02月, 日本産科婦人科学会雑誌, 64(2) (2), 546 - 546, 日本語
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)骨盤内腫瘍に対する術前診断に苦慮し,腹腔鏡下手術で完全摘出術を行った尿膜管癌の1例
- 2012年, 日本癌治療学会学術集会(CD-ROM), 50th妊娠中のCINから初期子宮頸癌の診断と治療
- 2012年, 産婦人科の進歩, 64(3) (3)進行卵巣癌NAC前の診断における腹腔鏡下手術の有用性について
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)腹腔鏡下手術で治療し得た腹膜妊娠の1例
- 2012年, 日本婦人科腫瘍学会雑誌, 30(3) (3)子宮頚部初期がんはどう治療するか
- 2012年, 日本婦人科腫瘍学会雑誌, 30(3) (3)子宮頸部初期病変治療後のピットフォール
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)術前に卵巣腫瘍と診断した脂肪成分を含む稀な充実性腫瘍の2例
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)血漿hCG低値の異所性妊娠に対して腹腔鏡下手術を施行した1例
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)当科における卵巣境界悪性腫瘍に対する腹腔鏡手術の経験
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)EBMに基づく子宮体がんに対する腹腔鏡下手術
- 2012年, 日本産科婦人科内視鏡学会雑誌, 28(1) (1)腹腔鏡下及び腹式筋腫核出後分娩の比較検討
- 2012年, 日本婦人科腫瘍学会雑誌, 30(3) (3)卵巣癌におけるエストロゲン受容体GPR30の上皮間葉転換(EMT)への関与
- 2012年, 日本婦人科腫瘍学会雑誌, 30(4) (4)婦人科癌の浸潤転移におけるEMT(Epithelial Mesenchymal Transition)の意義とEMT制御をターゲットとした新規治療の基礎的研究
- 2012年, 日本婦人科腫瘍学会雑誌, 30(3) (3)白金製剤耐性卵巣癌におけるAkt,ERKをターゲットとした分子標的薬としてのGemcitabineの機能解析
- 2012年, 日本癌治療学会学術集会(CD-ROM), 50th卵巣癌の播種転移はEMT現象を反映する
- 日本評論社, 2012年, からだの科学, (274) (274), 29 - 33, 日本語0期子宮頸がんの治療 (婦人科がんの最新医学) -- (子宮頸がんの最新医学)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 453 - 453, 日本語P1-11-8 婦人科悪性腫瘍手術及び術後化学療法の動脈硬化に及ぼす影響についての検討(Group11 婦人科腫瘍全般・症例3,一般演題,第64回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 454 - 454, 日本語P1-11-11 有経女性の婦人科悪性腫瘍治療の骨密度に及ぽす影響について(Group11 婦人科腫瘍全般・症例3,一般演題,第64回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 598 - 598, 日本語P2-3-4 白金製剤耐性卵巣癌におけるAktをターゲットとした分子標的薬としてのGemcitabineの機能解析(Group59 卵巣腫瘍・基礎3,一般演題)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 595 - 595, 日本語P2-2-8 卵巣癌におけるEMT現象の指標となるE-cadherin,snail,slugの発現意義(Group58 卵巣腫瘍・基礎2,一般演題)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 663 - 663, 日本語P2-22-2 閉経後女性における卵巣機能とウィミンズヘルス(Group78 更年期・老年期1,一般演題)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 626 - 626, 日本語P2-11-2 傍大動脈リンパ節郭清におけるナビゲーションシステムを用いた卵巣動脈温存術とその応用(Group67 卵巣腫瘍・診断・予後1,一般演題)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 779 - 779, 日本語P3-7-8 安全な広汎子宮全摘出術を目指した術式の開発 : 子宮動脈2点pull up法(Group119 子宮頸部腫瘍・治療3)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 804 - 804, 日本語P3-15-1 当院における子宮悪性腫瘍手術における腹腔鏡下手術(Group127 婦人科腫瘍・手術3)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 436 - 436, 日本語P1-7-1 子宮腺筋症癌化5症例における臨床病理学的検討(Group7 子宮体部腫瘍・診断・予後3,一般演題,第64回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 440 - 440, 日本語P1-8-4 子宮内膜癌のスクリーニング検査としての子宮鏡検査の有用性(Group8 子宮体部腫瘍・診断・治療1,一般演題,第64回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2012年, 日本産科婦人科學會雜誌, 64(2) (2), 420 - 420, 日本語P1-2-8 子宮体癌におけるEMTのマーカーとしてのCD24の有用性(Group2 子宮体部腫瘍・基礎2,一般演題,第64回日本産科婦人科学会学術講演会)
- 医学書院, 2011年10月, 臨床婦人科産科, 65(10) (10), 1239 - 1242, 日本語子宮頸部微小浸潤癌の治療戦略 (今月の臨床 子宮頸癌--予防と妊孕性温存のための治療戦略) -- (妊孕性温存のための治療戦略)
- 2011年, 日本臨床細胞学会雑誌, 50S状結腸癌の膣断端転移における細胞学的所見
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 773 - 773, 日本語P2-13-14 進行子宮頸癌患者に対する術前化学療法(neoadjuvant chemotherapy:NAC)の治療成績(Group94 子宮頸部腫瘍・治療5,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 784 - 784, 日本語P2-14-16 エストロゲン受容体GPR30の子宮内膜癌における制御機構の解明(Group97 子宮体部悪性腫瘍・基礎1,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 768 - 768, 日本語P2-12-24 当科での骨盤神経温存広汎子宮全摘術の妥当性とurodynamics studyによる排尿機能の評価(Group92 子宮頸部腫瘍・治療4,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 795 - 795, 日本語P2-15-18 子宮体癌においてEMT(上皮間葉転換)は予後因子となりえるか?(Group100 子宮体部悪性腫瘍・診断・予後,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 801 - 801, 日本語P2-16-11 子宮体癌における脈管侵襲と臨床病理学的因子の検討(Group103 子宮体部悪性腫瘍・診断・手術2,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 837 - 837, 日本語P2-20-23 卵巣癌におけるエストロゲン受容体GPR30およびER・PRの発現と臨床病理学的意義(Group114 悪性卵巣腫瘍・基礎4,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 842 - 842, 日本語P2-21-10 転移性卵巣粘液性腺癌の術前・術中診断のポイント : 2症例からの考察(Group115 悪性卵巣腫瘍・症例1,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 842 - 842, 日本語P2-21-9 子宮内膜性嚢胞癌化を示唆する画像所見の変化について : 3症例からの考察(Group115 悪性卵巣腫瘍・症例1,一般演題,第63回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2011年, 日本産科婦人科學會雜誌, 63(2) (2), 877 - 877, 日本語P2-24-26 婦人科悪性腫瘍における傍大動脈リンパ節郭清術の必要性と安全性(Group126 婦人科悪性腫瘍・手術合併症2,一般演題,第63回日本産科婦人科学会学術講演会)
- (一社)日本癌治療学会, 2010年09月, 日本癌治療学会誌, 45(2) (2), 1043 - 1043, 日本語神経温存広汎子宮全摘術における排尿機能の評価
- (公社)日本婦人科腫瘍学会, 2010年06月, 日本婦人科腫瘍学会雑誌, 28(3) (3), 279 - 279, 日本語卵巣がん治療ガイドライン2010年版について 卵巣がん治療ガイドライン 上皮性悪性卵巣腫瘍(概論・卵巣癌の治療・手術療法)
- 診断と治療社, 2010年03月, 産科と婦人科, 77(3) (3), 328 - 330, 日本語産婦人科教室 私たちの教室紹介(SERIES 3)大阪医科大学産婦人科学教室
- 2010年, 日本産科婦人科内視鏡学会雑誌, 26(1) (1)若年性卵巣腫瘍茎捻転の1例
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 436 - 436, 日本語P1-263 婦人科悪性腫瘍手術における傍大動脈リンパ節郭清は合併症を増加させるか?(Group32 婦人科腫瘍その他2,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 693 - 693, 日本語P3-207 卵巣癌における抗癌剤感受性に基づいた新規molecular markerとしてのNFκBの意義(Group124 卵巣腫瘍9,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 672 - 672, 日本語P3-143 婦人科悪性腫瘍に対して深部静脈血栓症(DVT)・肺血栓塞栓症(PE)のスクリーニング検査は必要か : 致死性PEを防ぐために(Group116 婦人科腫瘍血栓症2,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 420 - 420, 日本語P1-216 卵巣癌におけるGPR30とEGFRの免疫組織化学的検討(Group26 卵巣腫瘍2,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 419 - 419, 日本語P1-211 卵巣癌におけるEGFR遺伝子変異とその下流シグナル分子の発現解析(Group26 卵巣腫瘍2,一般演題,第62回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2010年, 日本産科婦人科學會雜誌, 62(2) (2), 516 - 516, 日本語P2-156 子宮頸癌術後治療におけるCCRTの合併症と抗癌化学療法の可能性について(Group63 子宮頸部悪性腫瘍4,一般演題,第62回日本産科婦人科学会学術講演会)
- 医学書院, 2009年12月, 臨床婦人科産科, 63(12) (12), 1486 - 1489, 日本語子宮頸部微小浸潤扁平上皮癌の子宮温存の適応と限界 (特集 QOLを考慮した婦人科がん治療) -- (妊孕能温存)
- 日本臨床社, 2009年08月, 日本臨床, 67, 210 - 214, 日本語頸部腫瘍 子宮頸部微小浸潤癌 (子宮疾患・子宮内膜症の臨床--基礎・臨床研究のアップデート) -- (腫瘍性疾患)
- 2009年, 日本産科婦人科内視鏡学会雑誌, 25(1) (1)エストロゲン・プロゲステロン合剤内服後に生じた子宮内外同時妊娠の1例
- 2009年, 日本産科婦人科内視鏡学会雑誌, 25(1) (1)経頚管的吸引法とMTXにより治療した子宮間質部妊娠の1例
- 日本産科婦人科学会, 2009年, 日本産科婦人科學會雜誌, 61(2) (2), 701 - 701, 日本語P3-100 CTよるリンパ節転移の画像診断の有用性(Group88 画像診断,一般演題,第61回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2009年, 日本産科婦人科學會雜誌, 61(2) (2), 676 - 676, 日本語P3-27 当科における子宮内膜間質肉腫症例の検討(Group79 子宮体部悪性腫瘍8,一般演題,第61回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2009年, 日本産科婦人科學會雜誌, 61(2) (2), 459 - 459, 日本語P1-39 子宮内膜癌に対するmedroxyprogesterone acetate(MPA)の作用機序(Group6 子宮体部悪性腫瘍4,一般演題,第61回日本産科婦人科学会学術講演会)
- 2008年12月, CLINICAL CANCER RESEARCH, 14(23) (23), 7781 - 7789, 英語, 国際誌
- 医学書院, 2008年10月, 臨床婦人科産科, 62(10) (10), 1332 - 1337, 日本語卵巣癌における抗癌剤耐性の克服 (今月の臨床 卵巣癌診療の最新情報) -- (卵巣癌治療の将来展望)
- 特定非営利活動法人日本臨床細胞学会, 2008年09月22日, 日本臨床細胞学会雑誌, 47(2) (2), 553 - 553, 日本語P-147 子宮体部原発神経内分泌腫瘍の1例(子宮体部(6),グローバル時代の細胞診,第47回日本臨床細胞学会秋期大会)
- 特定非営利活動法人日本臨床細胞学会, 2008年09月22日, 日本臨床細胞学会雑誌, 47(2) (2), 549 - 549, 日本語P-140 子宮体部癌肉腫の1症例(子宮体部(4),グローバル時代の細胞診,第47回日本臨床細胞学会秋期大会)
- 金原出版, 2008年09月, 産婦人科の実際, 57(9) (9), 1411 - 1419, 日本語産婦人科医が行う乳がん検診 (特集 婦人科がんの検診--その効果と問題点)
- 医学書院, 2008年04月, 臨床婦人科産科, 62(4) (4), 643 - 649, 日本語卵巣癌における分子標的治療の展望は? (今月の臨床 産婦人科臨床の難題を解く--私はこうしている) -- (婦人科癌治療 卵巣癌)
- 2008年, 産婦人科の進歩, 60(4) (4)腹壁子宮内膜症の一症例
- 日本産科婦人科学会, 2008年, 日本産科婦人科學會雜誌, 60(2) (2), 619 - 619, 日本語P2-17 局所進行子宮頸がん患者に対する術前化学療法CPT-11 iv/CDDP BOAI第II相試験(Group36 子宮頸部悪性腫瘍6,一般演題,第60回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2008年, 日本産科婦人科學會雜誌, 60(2) (2), 694 - 694, 日本語P2-242 Topoisomerase 1 inhibitorであるtopotecanのCDDP耐性解除機構(Group62 感染症3,一般演題,第60回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2008年, 日本産科婦人科學會雜誌, 60(2) (2), 563 - 563, 日本語P1-201 topoisomerase I inhibitorであるtopotecanはin vivoにおいてCDDP耐性を解除するか?(Group23 卵巣腫瘍1,一般演題,第60回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2008年, 日本産科婦人科學會雜誌, 60(2) (2), 769 - 769, 日本語P3-116 大動脈周囲リンパ節郭清術の合併症軽減に向けた工夫(Group80 卵巣腫瘍8,一般演題,第60回日本産科婦人科学会学術講演会)
- 特定非営利活動法人日本臨床細胞学会, 2007年09月22日, 日本臨床細胞学会雑誌, 46(2) (2), 541 - 541, 日本語260 短期間で進行した子宮体部明細胞腺癌の一症例(子宮体部2(9),一般演題,第46回日本臨床細胞学会秋期大会)
- 医学書院, 2007年02月, 臨床婦人科産科, 61(2) (2), 112 - 117, 日本語子宮体癌とSERM (今月の臨床 子宮体癌の最新知見--専門医のために)
- 日本産科婦人科学会, 2007年, 日本産科婦人科學會雜誌, 59(2) (2), 379 - 379, 日本語P1-91 局所進行子宮頸がん患者に対する術前化学療法CPT-11 iv/CDDP BOAI第II相試験(Group7 子宮頸部腫瘍7,一般演題,第59回日本産科婦人科学会学術講演会)
- 日本産科婦人科学会, 2007年, 日本産科婦人科學會雜誌, 59(2) (2), 589 - 589, 日本語P2-76 定期的子宮鏡検査で管理した子宮内膜癌と子宮内膜異型増殖症に対するMPA療法(Group111 子宮体部腫瘍10,一般演題,第59回日本産科婦人科学会学術講演会)
- (一社)日本癌治療学会, 2006年09月, 日本癌治療学会誌, 41(2) (2), 464 - 464, 日本語卵巣癌に対するDocetaxel+CBDCA(DJ)療法とweekly Paclitaxel+CBDCA(TJ)療法のRandomized Phase II study
- 第31回日本内視鏡外科学会, 2018年12月, 日本語, 福岡, 国内会議腹腔鏡下婦人科悪性腫瘍におけるセンチネルリンパ節ナビゲーション手術シンポジウム・ワークショップパネル（公募）
- 第31回日本内視鏡外科学会, 2018年12月, 日本語, 福岡, 国内会議当科で行っている腹腔鏡下神経温存広汎子宮全摘出術の実際シンポジウム・ワークショップパネル（公募）
- 第31回日本内視鏡外科学会, 2018年12月, 日本語, 福岡, 国内会議子宮体癌に対する腹腔鏡下手術適応拡大とさらなる低侵襲化を目指してシンポジウム・ワークショップパネル（公募）
- 第139回近畿産科婦人科学会総会ならびに学術集会, 2018年10月, 日本語, 大阪, 国内会議当院におけるHBOC診療体制の現況口頭発表（一般）
- 第56回日本癌治療学会, 2018年10月, 日本語, 横浜, 国内会議プラチナ感受性再発卵巣癌へのベバシズマブの有用性とプラチナフリー期間への関与口頭発表（一般）
- 第60回日本婦人科腫瘍学会, 2018年09月, 日本語, 京都, 国内会議腹腔鏡下子宮体癌手術の現状と展望シンポジウム・ワークショップパネル（公募）
- 第60回日本婦人科腫瘍学会, 2018年09月, 日本語, 京都, 国内会議化学療法無効の子宮内膜間質肉腫（high grade）に対してパゾパニブが効果を示した1 例口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議腹膜透析中の子宮内膜増殖症患者に対して腹腔鏡下子宮全摘出術を施行した一例口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議腹腔鏡手術を施行した妊娠合併未熟奇形腫の一例 －当院の未熟奇形腫後方視的検討を加えて口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議腹腔鏡下手術を施行した卵巣境界悪性腫瘍の予後の検討口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議腹腔鏡下手術で診断された卵巣原発偽粘液腫の1例口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議当院における腹腔鏡下子宮体癌手術の治療成績口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議当院における腹腔鏡下広汎子宮全摘出術と開腹広汎子宮全摘出術の検討口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議当院での子宮内膜症性嚢胞に対する腹腔鏡下手術後の再発予防について口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議第一助手を育てれば、術者が育つ口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議子宮内膜症合併不妊症における腹腔鏡下手術についての検討口頭発表（一般）
- 第58回日本産科婦人科内視鏡学会, 2018年08月, 日本語, 島根, 国内会議再発悪性腫瘍に対して、腹腔鏡下手術で腫瘍摘出しえた2例口頭発表（一般）
- 第138回近畿産科婦人科学会総会ならびに学術集会, 2018年06月, 日本語, 大阪, 国内会議境界悪性Brenner腫瘍の1例口頭発表（一般）
- 第138回近畿産科婦人科学会総会ならびに学術集会, 2018年06月, 日本語, 大阪, 国内会議13歳で手術を要した子宮筋腫の1例口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議卵巣境界悪性腫瘍・悪性腫瘍合併妊娠に対する腹腔鏡下手術の検討口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議分娩後1年以内の子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会）報告口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議腹腔鏡下婦人科悪性腫瘍におけるアドスプレーの有用性公開講演，セミナー，チュートリアル，講習，講義等
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議妊娠中子宮頸部円錐切除症例の後方視的解析 子宮頸部円錐切除術の実態調査に関する小委員会(婦人科腫瘍委員会）報告口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議早期子宮頸癌患者に対するリンパ節転移の診断には、FDG PET/CTとセンチネルリンパ節生検術のどちらが有用か？口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議進行・再発子宮頸癌における Bevacizumab 併用療法の有用性について口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議子宮内膜症合併卵巣がんと脂質異常症は関連しているか？口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議子宮体癌の骨盤リンパ節転移の予測においてのPET-CTとセンチネルリンパ節生検の有用性の比較口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議佐々木浩、丸岡 寛、大瀧瑠璃、飯藤宰士、越田裕一郎、中村真由美、太田沙緒里、穀内香奈、多賀紗也香、寺田信一、寺井義人、大道正英口頭発表（一般）
- 第70回日本産科婦人科学会, 2018年05月, 英語, 仙台, 国内会議Neoadjuvant intraarterial chemotherapy using an original four-lumen doubleballoon catheter for locally advanced uterine cervical cancer公開講演，セミナー，チュートリアル，講習，講義等
- 第70回日本産科婦人科学会, 2018年05月, 日本語, 仙台, 国内会議70歳以上の高齢者における腹腔鏡下手術の安全性の検討口頭発表（一般）
- 2017年度 腹腔鏡下子宮悪性腫瘍手術セミナー, 2018年02月, 日本語, 大阪, 国内会議膀胱、尿管損傷を回避するために我々が気を付けること ビデオを見ながら口頭発表（一般）
- 2017年度 腹腔鏡下子宮悪性腫瘍手術セミナー, 2018年02月, 日本語, 大阪, 国内会議婦人科腫瘍医が目指す腹腔鏡下手術公開講演，セミナー，チュートリアル，講習，講義等
- 第39回日本エンドメトリオーシス学会学術講演会, 2018年01月, 日本語, 京都, 国内会議子宮腺筋症に対するSequential療法の検討口頭発表（一般）