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池田 太郎
医学部附属病院 食道胃腸外科
助教

研究者基本情報

■ 学位
  • 博士(医学), 神戸大学

研究活動情報

■ 論文
  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Masayuki Ando, Yutaka Sugita, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Esophageal squamous cell carcinoma (ESCC) and hepatic cirrhosis (HC) share major risk factors, including alcohol consumption and smoking. Consequently, patients with HC exhibit an elevated incidence of ESCC. Although HC is widely recognized to contribute to poor prognosis following esophagectomy for ESCC, the underlying mechanisms remain poorly understood. This study aimed to investigate the association between hepatic fibrosis evaluated using the fibrosis-4 (FIB-4) index and postoperative outcomes among patients with ESCC undergoing esophagectomy. METHODS: We retrospectively analyzed 461 patients with ESCC who underwent minimally invasive esophagectomy at Kobe University Hospital. Hepatic fibrosis was evaluated using the FIB-4 index, which estimates liver fibrosis based on routine blood test parameters. Patients were stratified into two groups: fibrosis-positive (FIB-4 > 2.67) and fibrosis-negative (FIB-4 ≤ 2.67). RESULTS: Among patients with cT1 tumors, overall survival (OS) did not differ significantly between the two groups. However, among those with ≥cT2 tumors, the fibrosis-positive group showed significantly worse OS than the fibrosis-negative group (P = 0.0148). Additionally, the fibrosis-positive group had a significantly higher incidence of poor response to preoperative chemotherapy (P = 0.0075). Postoperative serum albumin levels were markedly lower at 3, 6, and 12 months in the fibrosis-positive group (P = 0.015, 0.043, and 0.0066, respectively). While albumin levels recovered to baseline in the fibrosis-negative group within 12 months, no such recovery was observed in the fibrosis-positive group. CONCLUSIONS: Preoperative hepatic fibrosis is associated with poor response to preoperative chemotherapy and prolonged postoperative malnutrition, contributing to poorer long-term survival outcomes among patients with ESCC undergoing minimally invasive esophagectomy.
    2026年01月, Annals of surgical oncology, 33(1) (1), 444 - 452, 英語, 国際誌
    研究論文(学術雑誌)

  • Taro Ikeda, Shingo Kanaji, Naoki Urakawa, Hitoshi Harada, Yutaka Sugita, Masayuki Ando, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND/AIM: Previous studies demonstrated the safety of laparoscopic gastrectomy in patients with locally advanced gastric cancer. However, the feasibility of minimally invasive surgery (MIS) following neoadjuvant chemotherapy (NAC) for locally advanced gastric cancer remains unclear. To our knowledge, no previous study has conducted a comprehensive analysis that evaluated NAC and surgical approach simultaneously. This study aimed to assess the feasibility of MIS for locally advanced gastric cancer after NAC using a four-arm comparison. PATIENTS AND METHODS: This study retrospectively analyzed 174 patients who underwent gastrectomy at Kobe University Hospital between January 2011 and July 2024. The patients were categorized into four groups based on NAC and surgical approaches: No NAC/open surgery (n=63), no NAC/MIS (n=49), NAC/open surgery (n=20), and NAC/MIS (n=42). We compared surgical and survival outcomes among the four groups. RESULTS: Patients in the group treated with NAC/MIS experienced less blood loss, fewer transfusions, and a shorter hospital stay. Additionally, compared with the NAC/open (20%) and no NAC/MIS (6.1%) groups, the rate of severe postoperative complications (grade ≥III) was lowest in the group treated with NAC/MIS, with no incidence of pancreatic fistula. The R0 resection rate was highest (97.6%) in the group treated with NAC/MIS. Although 5-year relapse-free survival and overall survival were higher in the group treated with NAC/MIS, the differences were not statistically significant. CONCLUSION: This four-arm study suggests that minimally invasive surgery after NAC for locally advanced gastric cancer may be technically and oncologically safe.
    2025年12月, Anticancer research, 45(12) (12), 5557 - 5566, 英語, 国際誌
    研究論文(学術雑誌)

  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Daisuke Miyawaki, Ryohei Sasaki, Yoshihiro Kakeji
    PURPOSE: Esophagectomy and chemoradiotherapy (CRT) are the mainstays of treatment for esophageal squamous cell carcinoma (ESCC). Older patients often do not receive full standard treatment due to physiological limitations. This study aimed to assess the long-term prognosis of surgery or non-surgery treatment for older patients with resectable ESCC. METHODS: This retrospective study included 114 patients who underwent esophagectomy (surgery group) and 65 patients who underwent CRT/radiotherapy (RT) (non-surgery group) at Kobe University Hospital. Propensity score matching was performed to identify matched patients in each tumor stage, including those with cT1N0 ESCC and cT1N-positive or cT2/3N-any ESCC. For cT1N0 ESCC, each group (surgery and non-surgery) had 14 patients. For cT1N-positive or cT2/3N-any ESCC, each group had 34 patients. RESULTS: After propensity score matching, for patients with cT1N0, the overall survival (OS) of the surgery group was significantly better than that of the non-surgery groups (p = 0.016). For cT1N-positive or cT2/3N-any patients, no significant differences were observed in OS between the two groups (p = 0.85). Before matching, in patients with cT1N0 ESCC, those who underwent RT alone had worse OS than patients who underwent surgery or CRT (p = 0.0003). In patients with cT1N-positive or cT2/3N-any ESCC, those who underwent RT alone or surgery alone had worse OS than those who underwent neoadjuvant chemotherapy plus surgery or CRT (p = 0.023). CONCLUSIONS: Patients who could not receive chemotherapy had poor survival. An appropriate treatment strategy should be considered, taking into account their general condition, especially their ability to receive chemotherapy.
    2025年10月, Esophagus : official journal of the Japan Esophageal Society, 22(4) (4), 546 - 556, 英語, 国内誌
    研究論文(学術雑誌)

  • Hitoshi Harada, Shingo Kanaji, Moe Tsuboi, Saki Nakatani, Satoko Tabuchi, Ikuko Yamamoto, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Michiko Takahashi, Yoshihiro Kakeji
    BACKGROUND & AIMS: Oral nutritional supplements (ONS) administered after gastrectomies can prevent postoperative weight loss. However, the amount of additional energy to be added to energy requirements after gastrectomy is unclear. This study aimed to clarify dietary energy intake and its association with weight loss in postgastrectomy patients. METHODS: We performed a single-center, single-arm, open-label, non-randomized clinical trial. Fifty patients with gastric cancer who underwent distal or total gastrectomy were included in this study. Until 3 months postoperatively, the patients continuously consumed ONS and their intake was recorded. Additionally, the patients took photos of their regular diets. Hospital visits were made every 2 weeks to investigate calorie intake (from regular diet plus ONS), physical findings, and nutritional status. The primary endpoint was the percentage of body weight loss (%BWL) at 3 months after gastrectomy. RESULTS: Data were available for 45 patients. %BWL was 7.5 ± 5.1 % at 3 months postoperatively. The group with ONS intake <200 kcal/day tended to show a lower %BWL; however, this was not significant. No correlation was observed between ONS and regular dietary calorie intake. The required calorie intake was 1588 ± 157 kcal/day. Calorie intake from regular diet alone and from regular diet plus ONS were 1330 ± 280 and 1487 ± 300 kcal/day, respectively. The sufficient group, whose total calorie intake met the requirements, had significantly reduced body weight loss, compared with the insufficient group. CONCLUSIONS: After gastrectomy, regular diet alone often fails to meet nutritional requirements, and ONS supplementation may reduce %BWL at 3 months postoperatively by correcting energy deficits. This study was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR; UMIN000047451; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054111).
    2025年10月, Clinical nutrition ESPEN, 69, 449 - 457, 英語, 国際誌
    研究論文(学術雑誌)

  • Yasufumi Koterazawa, Hironobu Goto, Tomoaki Aoki, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Yasunori Otowa, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    BACKGROUND: Several studies have compared robot-assisted minimally invasive esophagectomy (RAMIE) with conventional minimally invasive surgery (C-MIE). However, the anatomical factors that may make certain patients more suitable for RAMIE remains unclear. This study compared the surgical outcomes of RAMIE with those of C-MIE in patients with narrow mediastinum and left-shifted esophagus. METHODS: Between January 2017 and December 2023, 260 patients with esophageal squamous cell carcinoma (ESCC) who underwent MIE (C-MIE or RAMIE) at Kobe University Hospital were included in the study. We developed a new index to assess the narrow mediastinum and left-shifted esophagus at the tracheal bifurcation level using computed tomography imaging. Cox proportional hazards regression analyses were performed to identify the prognostic factors. RESULTS: Patients with a narrow mediastinum and left-shifted esophagus had a higher incidence of recurrent laryngeal nerve (RLN) palsy and fewer lymph nodes dissections than other patients (p = 0.026 and p = 0.051, respectively). In the entire cohort, the operative time in the RAMIE group was longer than that in the C-MIE group (< 0.0001). No significant differences in other variables, including RLN palsy, were observed between the two groups. Among patients with narrow mediastinum and left-shifted esophagus, RAMIE was associated with longer operative time and fewer lymph nodes dissected from the left and right sides of the upper mediastinum compared to C-MIE (p < 0.0001, 0.0001, and 0.0001, respectively). Regarding the RLN palsy, there was no significant difference (p = 0.79). CONCLUSIONS: There are challenges in performing RAMIE in patients with a narrow mediastinal and left-shifted esophagus. Therefore, establishing an effective procedure for these patients is important.
    2025年07月, Surgical endoscopy, 39(7) (7), 4156 - 4165, 英語, 国際誌
    研究論文(学術雑誌)

  • Shingo Kanaji, Naoki Urakawa, Hitoshi Harada, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Ryuichiro Sawada, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Outcomes for advanced gastric cancer are improving with multidisciplinary treatment combining surgical resection and perioperative chemotherapy. In Asia, the standard of care for pathological Stage (pStage) II gastric cancer involves tegafur-gimeracil-oteracil potassium for 1 year postoperatively after gastrectomy with D2 lymph node dissection or capecitabine plus oxaliplatin for 6 months postoperatively. For pStage III gastric cancer, a combination of tegafur, gimeracil, and oteracil potassium combined with docetaxel remains the standard postoperative treatment. However, perioperative chemotherapy combined with surgery is being developed to further improve outcomes, similar to approaches in Europe. In addition, the perioperative use of molecularly targeted agents, such as trastuzumab, and immune checkpoint inhibitors, such as pembrolizumab, is expected to improve outcomes. Furthermore, improved chemotherapy outcomes have increased opportunities for surgical intervention in Stage IV gastric cancer, which was previously not indicated for surgery. In this article, we reviewed multidisciplinary treatments for Stage II-IV gastric cancer, combining surgery and chemotherapy.
    2025年07月, International journal of clinical oncology, 30(7) (7), 1268 - 1275, 英語, 国内誌
    研究論文(学術雑誌)

  • Ogawa S., Endo H., Yoshida M., Tsuru T., Itabashi M., Yamamoto H., Kakeji Y., Ueno H., Shirabe K., Hibi T., Taketomi A., Ikeda N., Mori M.
    Abstract Aim During the COVID‐19 pandemic, there were delays in transport of emergency cases to hospital by ambulance due to increased difficulties in obtaining hospital acceptance. The aim of this study was to examine if this had a negative effect on postoperative short‐term outcomes in patients with colorectal perforation. Methods The National Clinical Database (NCD) includes >95% of surgical cases in Japan. Postoperative 30‐day mortality, surgical mortality, and postoperative complications (Clavien–Dindo grade ≥3) were examined in 17 770 cases of colorectal perforation registered from 2019 to 2022 in the NCD. These outcomes were compared for cases with new COVID‐19 infection and emergency cases with difficulties in transport to hospital. Months were considered to have significantly high or low mortality or complication rates, if the 95% confidence interval (CI) of the standardized mortality (morbidity) ratio (SMR) did not contain 1. Results Postoperative 30‐day mortality occurred in 1826 cases (10.3%), surgical mortality in 2382 cases (13.4%), and postoperative complications in 5276 cases (29.7%). Significantly higher SMRs were found for 30‐day mortality in November 2020 (1.44 [95% CI: 1.07–1.89]) and February 2021 (1.54 [95% CI: 1.14–2.03]), and for postoperative complications in June 2020 (1.27 [95% CI: 1.07–1.50]). In 2022, there were marked increases in new COVID‐19 cases and in emergency cases with difficulties in transport to hospital, but no month had a significantly high SMR. Conclusions Emergency cases with difficulties in transport markedly increased during the COVID‐19 pandemic but had little effect on short‐term outcomes of colorectal perforation.
    Wiley, 2025年05月, Annals of Gastroenterological Surgery, 9(3) (3), 505 - 517
    研究論文(学術雑誌)

  • Yasufumi Koterazawa, Hironobu Goto, Tatsuya Kaneko, Yuki Azumi, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
    PURPOSE: Elderly patients with esophageal squamous cell carcinoma (ESCC) have more comorbidities than young patients do. Elderly smokers have a high mortality rate owing to physical dysfunction. This study aimed to identify risk factors for long-term outcomes after minimally invasive esophagectomy (MIE) in elderly patients with ESCC. METHODS: This study included 110 elderly patients (aged ≥ 75 years) with ESCC who underwent MIE at Kobe University Hospital. Multivariate Cox proportional hazards regression analyses were performed to identify risk factors, including the geriatric nutritional risk index (GNRI), Charlson comorbidity index, and elderly smoker status, defined as smoking at the age of 70 years. RESULTS: Multivariate analysis identified that elderly smokers, cT or cN status (≥ cT2 or cN-positive), and GNRI (≤ 92) were independent prognostic factors for overall survival (p = 0.026, 0.019, and 0.038, respectively). For patients with ≥ cT2 or cN-positive ESCC, elderly smokers or patients with GNRI (≤ 92) have significantly worse survival (p = 0.038). Elderly smokers were at risk of death from other diseases five years postoperatively (p = 0.016). CONCLUSIONS: Elderly smokers, cT2 or cN positivity, and low GNRI were risk factors for poor survival. Furthermore, for patients with ≥ cT2 or cN-positive ESCC, these risk factors were associated with poor survival.
    2025年05月, Surgery today, 55(5) (5), 659 - 667, 英語, 国内誌
    研究論文(学術雑誌)

  • Yuki Azumi, Naoki Urakawa, Shingo Kanaji, Hiroki Yokoo, Atsushi Shimada, Ryuichiro Sawada, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Hitoshi Harada, Yasunori Otowa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Overlap anastomosis is widely used in gastrointestinal reconstruction during minimally invasive gastrectomy. The entry hole of the anastomosis is typically closed with hand-sewn sutures because of concerns about stenosis. This study aimed to compare the efficacy of linear stapler (LS) closure with that of hand-sewn closure of the entry hole in overlap anastomosis. METHODS: We included 172 patients who underwent overlap anastomosis during laparoscopic or robot-assisted total gastrectomy (TG, Roux-en-Y) or distal gastrectomy (DG, Roux-en-Y/Billroth II) between February 2020 and September 2024. The patients were divided into two groups based on the method of entry hole closure: the suturing group (S group) and the LS group. Surgical outcomes were retrospectively analyzed. RESULTS: There were no significant differences in patient characteristics or tumor staging between the two groups. TG was performed in 46 and 17 patients in the S and LS groups, respectively, whereas DG was performed in 41 and 68 patients in the S and LS groups, respectively. In TG patients, there was no significant difference in operative time, but the esophageal-jejunal overlap anastomosis time was significantly shorter in the LS group (38.3 vs. 20.5 min, P < 0.001). The incidence of postoperative complications was similar in both groups, and no cases of stenosis were observed in the LS group. In DG patients, the operative time and gastric-jejunal overlap anastomosis time were significantly shorter in the LS group (294 min vs. 253 min, P = 0.002; 28.5 vs. 9.0 min, P < 0.001). The length of postoperative hospital stay was significantly shorter in the LS group (13 vs. 11 days, P = 0.01). CONCLUSION: Using an LS to close the entry hole in an overlapping anastomosis during minimally invasive gastrectomy can reduce the anastomosis time and may be a safe option without increasing the risk of stenosis.
    2025年05月, Surgical endoscopy, 39(5) (5), 3346 - 3353, 英語, 国際誌
    研究論文(学術雑誌)

  • Naoki Urakawa, Shingo Kanaji, Ryuichiro Sawada, Yasufumi Koterazawa, Taro Ikeda, Hitoshi Harada, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    BACKGROUND: Neoadjuvant chemotherapy is widely recognized as the established treatment for advanced gastric cancer. However, predicting its efficacy before surgery remains challenging. AIM: The present study aimed to evaluate the effectiveness of 18F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) as a predictor of treatment response to the S-1+Oxaliplatin regimen (SOX). METHODS AND RESULTS: Thirty patients who underwent gastrectomy following neoadjuvant SOX between January 2021 and July 2023 were included. Patients underwent FDG-PET pre- and postsurgery. The maximum standardized uptake value (SUVmax) from FDG-PET was examined in relation to histological tumor response and prognosis. SUVmax decreased significantly after chemotherapy in all patients (p < 0.001), especially in those with Grade 1a, 2, and 3 tumors (p < 0.05). SUV reduction increased stepwise with the histological response grade. Optimal cut-off values for the percentage decrease in SUVmax (ΔSUVmax) predictive of histologic efficacy were identified as 53% (area under curve 0.855, p = 0.0018) for Grade 1b or higher and 75% (area under curve 0.806, p = 0.0044) for Grade 2 or higher. Patients with ΔSUVmax > 50% had improved recurrence-free survival (p = 0.027). CONCLUSION: FDG-PET may be useful as a predictor of treatment response in neoadjuvant SOX therapy for gastric cancer. The determination of the optimal ΔSUVmax value may enhance the precision of histological tumor response prediction.
    2025年04月, Cancer reports (Hoboken, N.J.), 8(4) (4), e70190, 英語, 国際誌
    研究論文(学術雑誌)

  • RIKUYA TORIGOE, TARO OSHIKIRI, HIRONOBU GOTO, YASUHUMI KOTERAZAWA, RYUICHIRO SAWADA, TARO IKEDA, HITOSHI HARADA, NAOKI URAKAWA, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, TAKERU MATSUDA, YOSHIHIRO KAKEJI
    Anticancer Research USA Inc., 2024年12月, Anticancer Research, 44(12) (12), 5485 - 5493
    研究論文(学術雑誌)

  • Hiroki Yokoo, Shingo Kanaji, Taro Ikeda, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 101934 - 101934
    研究論文(学術雑誌)

  • Hironobu Goto, Taro Oshikiri, Yasufumi Koterazawa, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji
    Springer Science and Business Media LLC, 2024年09月, Esophagus, 22(1) (1), 59 - 67
    研究論文(学術雑誌)

  • Kazumasa Horie, Taro Oshikiri, Yu Kitamura, Masaki Shimizu, Yuta Yamazaki, Hiroki Sakamoto, Sonoko Ishida, Yasufumi Koterazawa, Taro Ikeda, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
    INTRODUCTION: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR-S). MATERIALS AND SURGICAL TECHNIQUE: A 75-year-old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection. DISCUSSION: TRGR-S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR-S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.
    2020年07月, Asian journal of endoscopic surgery, 13(3) (3), 461 - 464, 英語, 国内誌
    研究論文(学術雑誌)

  • Taro Ikeda, Michiru Nishita, Kyoka Hoshi, Takashi Honda, Yoshihiro Kakeji, Yasuhiro Minami
    Abstract Bone marrow‐derived mesenchymal stem or stromal cells (MSC) have been shown to be recruited to various types of tumor tissues, where they interact with tumor cells to promote their proliferation, survival, invasion and metastasis, depending on the type of the tumor. We have previously shown that Ror2 receptor tyrosine kinase and its ligand, Wnt5a, are expressed in MSC, and Wnt5a‐Ror2 signaling in MSC induces expression of CXCL16, which, in turn, promotes proliferation of co–cultured MKN45 gastric cancer cells via the CXCL16‐CXCR6 axis. However, it remains unclear how CXCL16 regulates proliferation of MKN45 cells. Here, we show that knockdown of CXCL16 in MSC by siRNA suppresses not only proliferation but also migration of co–cultured MKN45 cells. We also show that MSC‐derived CXCL16 or recombinant CXCL16 upregulates expression of Ror1 through activation of STAT3 in MKN45 cells, leading to promotion of proliferation and migration of MKN45 cells in vitro. Furthermore, co–injection of MSC with MKN45 cells in nude mice promoted tumor formation in a manner dependent on expression of Ror1 in MKN45 cells, and anti–CXCL16 neutralizing antibody suppressed tumor formation of MKN45 cells co–injected with MSC. These results suggest that CXCL16 produced through Ror2‐mediated signaling in MSC within the tumor microenvironment acts on MKN45 cells in a paracrine manner to activate the CXCR6‐STAT3 pathway, which, in turn, induces expression of Ror1 in MKN45 cells, thereby promoting tumor progression.
    Wiley, 2020年02月, Cancer Science, 111(4) (4), 1254 - 1265
    研究論文(学術雑誌)

  • Taro Ikeda, Shingo Kanaji, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji
    Objectives: Dissection of the No. 11p lymph nodes is technically challenging because of variations in anatomical landmarks. This study aimed to determine the accuracy and efficacy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography simulation. Methods: Laparoscopic gastrectomy with No. 11p lymph node dissection with preoperative simulation using three-dimensional computed tomography was performed in 24 patients at our institution from October 2016 to May 2018. Initially, preoperative three-dimensional computed tomography findings with operative videos in these 24 patients were compared. The dorsal landmark was defined as an anatomical structure behind the splenic artery on preoperative three-dimensional computed tomography and operative videos. The dorsal landmark of No. 11p lymph node was divided into four types: (1) splenic vein type, (2) splenic vein and pancreas type, (3) pancreas type, and (4) unclear type. Then, to investigate the efficacy of three-dimensional computed tomography, we compared the clinical and pathological features and surgical outcomes of nine patients who underwent preoperative three-dimensional computed tomography simulation (three-dimensional computed tomography group) and 23 patients who did not undergo three-dimensional computed tomography simulation from August 2014 to September 2016 (non-three-dimensional computed tomography group). All procedures were performed by one surgeon certified by the Endoscopic Surgical Skill Qualification System in Japan. Results: The concordance rate between three-dimensional computed tomography and operative videos of the dorsal landmark using three-dimensional computed tomography was 79% (19/24). The operative time of No. 11p lymph node dissection was significantly shorter in the three-dimensional computed tomography group than in the non-three-dimensional computed tomography group (7.7 versus 15.8 min, P = 0.044). Conclusion: The accuracy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography was extremely high. Preoperative simulation with three-dimensional computed tomography was useful in shortening the operative time of No. 11p lymph node dissection.
    SAGE Publications, 2020年01月, SAGE Open Medicine, 8, 205031212093691 - 205031212093691
    研究論文(学術雑誌)

  • 池田 太郎, 金治 新悟, 永田 真知子, 青木 丈明, 山本 将士, 掛地 吉弘
    (株)南江堂, 2019年06月, 外科, 81(7) (7), 716 - 720, 日本語

  • Tomoaki Aoki, Michiru Nishita, Junya Sonoda, Taro Ikeda, Yoshihiro Kakeji, Yasuhiro Minami
    Collective invasion is an important strategy of cancers of epithelial origin, including colorectal cancer (CRC), to infiltrate efficiently into local tissues as collective cell groups. Within the groups, cells at the invasive front, called leader cells, are highly polarized and motile, thereby providing the migratory traction that guides the follower cells. However, its underlying mechanisms remain unclear. We have previously shown that signaling emanating from the receptor tyrosine kinase Ror2 can promote invasion of human osteosarcoma cells and that intraflagellar transport 20 (IFT20) mediates its signaling to regulate Golgi structure and transport. Herein, we investigated the role of Ror2 and IFT20 in collective invasion of CRC cells, where Ror2 expression is either silenced or nonsilenced. We show by cell biological analyses that IFT20 promotes collective invasion of CRC cells, irrespective of expression and function of Ror2. Intraflagellar transport 20 is required for organization of Golgi‐associated, stabilized microtubules, oriented toward the direction of invasion in leader cells. Our results also indicate that IFT20 promotes reorientation of the Golgi apparatus toward the front side of leader cells. Live cell imaging of the microtubule plus‐end binding protein EB1 revealed that IFT20 is required for continuous polarized microtubule growth in leader cells. These results indicate that IFT20 plays an important role in collective invasion of CRC cells by regulating organization of Golgi‐associated, stabilized microtubules and Golgi polarity in leader cells.
    Wiley, 2019年02月, Cancer Science, 110(4) (4), 1306 - 1316
    研究論文(学術雑誌)

  • 【胃癌・食道癌のリンパ節郭清のすべて】食道癌に対する中下縦隔リンパ節郭清
    押切 太郎, 中村 哲, 池田 太郎, 後藤 裕信, 山本 将士, 金治 新悟, 鈴木 知志, 掛地 吉弘
    (株)へるす出版, 2017年01月, 消化器外科, 40(1) (1), 41 - 55, 日本語

■ MISC
  • 根治的胃切除を行った高齢胃癌患者における予後因子としての周術期Geriatric Nutritional Risk Indexの有用性
    原田仁, 金治新悟, 澤田隆一郎, 池田太郎, 小寺澤康文, 青木丈明, 裏川直樹, 後藤裕信, 長谷川寛, 山下公大, 松田武, 掛地吉弘
    2025年, 日本外科学会定期学術集会(Web), 125th

■ 講演・口頭発表等
  • 間葉系幹細胞由来のCXCL16は胃癌細胞においてSTAT3経路を介してRor1の発現を誘導し増殖と遊走を促進する
    池田 太郎、西田 満、瀧口 豪介、裏川 直樹、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、鈴木 知志、南 康博、掛地 吉弘
    第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議
    ポスター発表

  • 早期胃癌に対するESD後の追加外科切除症例の検討
    池田 太郎、金治 新悟、鈴木 知志、掛地 吉弘
    日本消化器病学会近畿支部第111回例会, 日本語, 神戸大学大学院医学研究科外科学講座食道胃腸外科学, 大阪, 日本国, 国内会議
    シンポジウム・ワークショップパネル(公募)

  • 間葉系間質細胞由来のCXCL16は胃癌細胞においてRor1の発現を誘導し増殖と遊走を促進する
    池田 太郎、西田 満、掛地 吉弘、南 康博
    第78回日本癌学会学術総会, 日本語, 京都大学大学院 生命科学研究科, 京都, 日本国, 国内会議
    ポスター発表

  • 胃癌に対する腹腔鏡下脾動脈近位側郭清における画像によるシミュレーションと左外側アプローチの有用性
    金治 新悟、鈴木 知志、池田 太郎、山本 将士、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、掛地 吉弘
    第74回日本消化器外科学会総会, 日本語, 東京慈恵会医科大学, 東京, 日本国, 国内会議
    口頭発表(一般)

  • The long-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patients
    Suzuki S, Ikeda T, Urakawa N, Kanaji S, Yamamoto M, Matsuda Y, Kakeji Y
    IGCC 2019 第13回国際胃癌学会議(13th INTERNATIONAL GASTRIC CANCER CONGRESS), 英語, University of Leipzig, Prague, チェコ共和国, 国際会議
    ポスター発表

  • 3D-CTを用いた脾動脈幹近位リンパ節背側境界の術前シミュレーションの有用性
    池田 太郎、金治 新悟、瀧口 豪介、高瀬 信尚、長谷川 寛、山本 将士、松田 佳子、松田 武、押切 太郎、中村 哲、鈴木 知志、掛地 吉弘
    第119回日本外科学会定期学術集会, 日本語, 一般社団法人日本外科学会, 大阪, 日本国, 国内会議
    その他

  • 腹腔鏡下胃癌手術における術前CTを用いた難易度予測
    池田 太郎、金治 新悟、後藤 裕信、大坪 大、山本 将士、松田 佳子、松田 武、押切 太郎、中村 哲、角 泰雄、鈴木 知志、藤野 泰宏、富永 正寛、掛地 吉弘
    第31回日本内視鏡外科学会総会, 日本語, 一般社団法人日本内視鏡外科学会, 福岡, 日本国, 国内会議
    口頭発表(一般)

  • 胸腔鏡下食道切除術に対する3D内視鏡の導入と治療成績
    中村 哲、小寺澤 康文、澤田 隆一郎、池田 太郎、渋谷 尚樹、青木 丈明、三浦 由紀子、原田 仁、中川 暁雄、西 将康、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、鈴木 知志、掛地 吉弘
    第118回日本外科学会定期学術集会, 日本語, 一般社団法人日本外科学会, 東京, 日本国, 国内会議
    その他

  • 当科における噴門部GISTの手術成績と治療戦略の検討
    池田 太郎、金治 新悟、長谷川 寛、山本 将士、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、角 泰雄、鈴木 知志、掛地 吉弘
    第14回日本消化管学会総会学術集会, 日本語, 一般社団法人日本消化管学会, 東京, 日本国, 国内会議
    シンポジウム・ワークショップパネル(公募)

  • 進行胃癌に対する腹腔鏡下膵上縁郭清
    金治 新悟、鈴木 知志、池田 太郎、山本 将士、長谷川 寛、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、中村 哲、掛地 吉弘
    第30回日本内視鏡外科学会総会, 日本語, 京都大学 医学部 消化管外科, 京都, 日本国, 国内会議
    シンポジウム・ワークショップパネル(公募)

  • 術前化学放射線療法を施行した局所進行肛門管癌に対して有茎腹直筋皮弁再建が有用であった1例
    池田 太郎、松田 武、福岡 英志、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、押切 太郎、中村 哲、角 泰雄、鈴木 知志、掛地 吉弘
    第200回近畿外科学会, 日本語, 京都府立医科大学 消化器外科, 京都, 日本国, 国内会議
    口頭発表(一般)

  • Prone position in thoracoscopic esophagectomy improves postoperative oxygenation and reduces pulmonary complications
    Ikeda T, Nakamura T, Otsubo D, Yamamoto M, Kanaji S, Imanishi T, Oshikiri T, Sumi Y, Suzuki S, Kutoda D, Kakeji Y
    40th World Congress of the International College of Surgeons/62nd Annual Congress of the International College of Surgeons Japan Section(第40回国際外科学会・第62回国際外科学会日本部会総会), 英語, 国際外科学会、第40回国際外科学会世界総会組織委員会、日本学術会議, 京都, 日本国, 国際会議
    シンポジウム・ワークショップパネル(公募)

  • 腹臥位食道癌手術における左上縦隔郭清の定型化
    池田 太郎、押切 太郎、中村 哲、古出 隆大、山本 将士、長谷川 寛、金治 新悟、松田 佳子、山下 公大、松田 武、角 泰雄、鈴木 知志、掛地 吉弘
    第29回近畿内視鏡外科研究会, 日本語, 関西医科大学 腎泌尿器外科学講座, 京都, 日本国, 国内会議
    シンポジウム・ワークショップパネル(公募)

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