研究活動情報

• Prognostic Impact of Squamous Cell Carcinoma Antigen During Neoadjuvant Chemotherapy for Patients With Esophageal Squamous Cell Carcinoma Treated With Minimally Invasive Esophagectomy

  RIKUYA TORIGOE, TARO OSHIKIRI, HIRONOBU GOTO, YASUHUMI KOTERAZAWA, RYUICHIRO SAWADA, TARO IKEDA, HITOSHI HARADA, NAOKI URAKAWA, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, TAKERU MATSUDA, YOSHIHIRO KAKEJI

  Anticancer Research USA Inc., 2024年12月, Anticancer Research, 44(12) (12), 5485 - 5493


• Surgical Technique and Safety of Gastrectomy for Gastric Cancer with Duodenal Invasion, Including Minimally Invasive Approach

  Hiroki Yokoo, Shingo Kanaji, Taro Ikeda, Yasufumi Koterazawa, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji

  Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 101934 - 101934


• The totally mechanical Collard technique for cervical esophagogastric anastomosis reduces anastomotic stricture compared with triangular anastomosis in minimally invasive esophagectomy with gastric conduit reconstruction through the retrosternal route: a propensity score-matched study

  Hironobu Goto, Taro Oshikiri, Yasufumi Koterazawa, Ryuichiro Sawada, Taro Ikeda, Hitoshi Harada, Naoki Urakawa, Hiroshi Hasegawa, Shingo Kanaji, Kimihiro Yamashita, Takeru Matsuda, Yoshihiro Kakeji

  Springer Science and Business Media LLC, 2024年09月, Esophagus, 22(1) (1), 59 - 67


• Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer.

  Kazumasa Horie, Taro Oshikiri, Yu Kitamura, Masaki Shimizu, Yuta Yamazaki, Hiroki Sakamoto, Sonoko Ishida, Yasufumi Koterazawa, Taro Ikeda, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji

  INTRODUCTION: Recent advances in the treatment for esophageal cancer have improved the prognosis after esophagectomy, but they have led to an increased incidence of gastric tube cancer. In most patients who underwent retrosternal reconstruction, median sternotomy is performed; it is associated with a risk of postoperative bleeding and osteomyelitis, and pain often negatively affects respiration. Here, we report the first case of thoracoscopic retrosternal gastric conduit resection in the supine position (TRGR-S). MATERIALS AND SURGICAL TECHNIQUE: A 75-year-old male patient was placed in the supine position. Four ports were placed in the left chest wall. The gastric tube was separated from the epicardium, sternum, and left brachiocephalic vein. Because of adhesions between the gastric tube and the right pleura, combined resection of the right pleura was performed. The dorsal side of the gastric tube was dissected before the ventral side, enabling the gastric tube to be suspended from the back of the sternum and, thus, making it easier to expose the surgical field. Next, pedicled jejunal reconstruction via the presternal route was performed. There were no postoperative complications. The pathological diagnosis was signet ring cell carcinoma (pT1b, pN0, M0, pStage I), indicating R0 resection. DISCUSSION: TRGR-S does not require sternotomy, reducing the risk of postoperative bleeding and osteomyelitis. In the presence of adhesions, TRGR-S is safe and provides a good surgical view. It is also reliable procedure for resection of retrosternal gastric tube cancer, and it is ergonomic for surgeons.

  2020年07月, Asian journal of endoscopic surgery, 13(3) (3), 461 - 464


• Mesenchymal stem cell‐derived CXCL16 promotes progression of gastric cancer cells by STAT3‐mediated expression of Ror1

  Taro Ikeda, Michiru Nishita, Kyoka Hoshi, Takashi Honda, Yoshihiro Kakeji, Yasuhiro Minami

  Abstract Bone marrow‐derived mesenchymal stem or stromal cells (MSC) have been shown to be recruited to various types of tumor tissues, where they interact with tumor cells to promote their proliferation, survival, invasion and metastasis, depending on the type of the tumor. We have previously shown that Ror2 receptor tyrosine kinase and its ligand, Wnt5a, are expressed in MSC, and Wnt5a‐Ror2 signaling in MSC induces expression of CXCL16, which, in turn, promotes proliferation of co–cultured MKN45 gastric cancer cells via the CXCL16‐CXCR6 axis. However, it remains unclear how CXCL16 regulates proliferation of MKN45 cells. Here, we show that knockdown of CXCL16 in MSC by siRNA suppresses not only proliferation but also migration of co–cultured MKN45 cells. We also show that MSC‐derived CXCL16 or recombinant CXCL16 upregulates expression of Ror1 through activation of STAT3 in MKN45 cells, leading to promotion of proliferation and migration of MKN45 cells in vitro. Furthermore, co–injection of MSC with MKN45 cells in nude mice promoted tumor formation in a manner dependent on expression of Ror1 in MKN45 cells, and anti–CXCL16 neutralizing antibody suppressed tumor formation of MKN45 cells co–injected with MSC. These results suggest that CXCL16 produced through Ror2‐mediated signaling in MSC within the tumor microenvironment acts on MKN45 cells in a paracrine manner to activate the CXCR6‐STAT3 pathway, which, in turn, induces expression of Ror1 in MKN45 cells, thereby promoting tumor progression.

  Wiley, 2020年02月, Cancer Science, 111(4) (4), 1254 - 1265


• Significance of prediction of the dorsal landmark using three-dimensional computed tomography during laparoscopic lymph node dissection along the proximal splenic artery in gastric cancer

  Taro Ikeda, Shingo Kanaji, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Satoshi Suzuki, Yoshihiro Kakeji

  SAGE Publications, 2020年01月, SAGE Open Medicine, 8, 205031212093691 - 205031212093691


• 【消化管術後合併症-発症要因と対応】胃術後食物停滞の発症要因,予防対策と対応

  池田 太郎, 金治 新悟, 永田 真知子, 青木 丈明, 山本 将士, 掛地 吉弘

  (株)南江堂, 2019年06月, 外科, 81(7) (7), 716 - 720


• Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi‐associated microtubules

  Tomoaki Aoki, Michiru Nishita, Junya Sonoda, Taro Ikeda, Yoshihiro Kakeji, Yasuhiro Minami

  Collective invasion is an important strategy of cancers of epithelial origin, including colorectal cancer (CRC), to infiltrate efficiently into local tissues as collective cell groups. Within the groups, cells at the invasive front, called leader cells, are highly polarized and motile, thereby providing the migratory traction that guides the follower cells. However, its underlying mechanisms remain unclear. We have previously shown that signaling emanating from the receptor tyrosine kinase Ror2 can promote invasion of human osteosarcoma cells and that intraflagellar transport 20 (IFT20) mediates its signaling to regulate Golgi structure and transport. Herein, we investigated the role of Ror2 and IFT20 in collective invasion of CRC cells, where Ror2 expression is either silenced or nonsilenced. We show by cell biological analyses that IFT20 promotes collective invasion of CRC cells, irrespective of expression and function of Ror2. Intraflagellar transport 20 is required for organization of Golgi‐associated, stabilized microtubules, oriented toward the direction of invasion in leader cells. Our results also indicate that IFT20 promotes reorientation of the Golgi apparatus toward the front side of leader cells. Live cell imaging of the microtubule plus‐end binding protein EB1 revealed that IFT20 is required for continuous polarized microtubule growth in leader cells. These results indicate that IFT20 plays an important role in collective invasion of CRC cells by regulating organization of Golgi‐associated, stabilized microtubules and Golgi polarity in leader cells.

  Wiley, 2019年02月, Cancer Science, 110(4) (4), 1306 - 1316


• 【胃癌・食道癌のリンパ節郭清のすべて】食道癌に対する中下縦隔リンパ節郭清

  押切 太郎, 中村 哲, 池田 太郎, 後藤 裕信, 山本 将士, 金治 新悟, 鈴木 知志, 掛地 吉弘

  (株)へるす出版, 2017年01月, 消化器外科, 40(1) (1), 41 - 55

• 間葉系幹細胞由来のCXCL16は胃癌細胞においてSTAT3経路を介してRor1の発現を誘導し増殖と遊走を促進する

  池田 太郎、西田 満、瀧口 豪介、裏川 直樹、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、鈴木 知志、南 康博、掛地 吉弘

  第120回日本外科学会定期学術集会, 慶応義塾大学医学部外科学教室, web開催


• 早期胃癌に対するESD後の追加外科切除症例の検討

  池田 太郎、金治 新悟、鈴木 知志、掛地 吉弘

  日本消化器病学会近畿支部第111回例会, 神戸大学大学院医学研究科外科学講座食道胃腸外科学, 大阪


• 間葉系間質細胞由来のCXCL16は胃癌細胞においてRor1の発現を誘導し増殖と遊走を促進する

  池田 太郎、西田 満、掛地 吉弘、南 康博

  第78回日本癌学会学術総会, 京都大学大学院 生命科学研究科, 京都


• 胃癌に対する腹腔鏡下脾動脈近位側郭清における画像によるシミュレーションと左外側アプローチの有用性

  金治 新悟、鈴木 知志、池田 太郎、山本 将士、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、掛地 吉弘

  第74回日本消化器外科学会総会, 東京慈恵会医科大学, 東京


• The long-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patients

  Suzuki S, Ikeda T, Urakawa N, Kanaji S, Yamamoto M, Matsuda Y, Kakeji Y

  IGCC 2019 第13回国際胃癌学会議（13th INTERNATIONAL GASTRIC CANCER CONGRESS), University of Leipzig, Prague


• 3D-CTを用いた脾動脈幹近位リンパ節背側境界の術前シミュレーションの有用性

  池田 太郎、金治 新悟、瀧口 豪介、高瀬 信尚、長谷川 寛、山本 将士、松田 佳子、松田 武、押切 太郎、中村 哲、鈴木 知志、掛地 吉弘

  第119回日本外科学会定期学術集会, 一般社団法人日本外科学会, 大阪


• 腹腔鏡下胃癌手術における術前CTを用いた難易度予測

  池田 太郎、金治 新悟、後藤 裕信、大坪 大、山本 将士、松田 佳子、松田 武、押切 太郎、中村 哲、角 泰雄、鈴木 知志、藤野 泰宏、富永 正寛、掛地 吉弘

  第31回日本内視鏡外科学会総会, 一般社団法人日本内視鏡外科学会, 福岡


• 胸腔鏡下食道切除術に対する３Ｄ内視鏡の導入と治療成績

  中村 哲、小寺澤 康文、澤田 隆一郎、池田 太郎、渋谷 尚樹、青木 丈明、三浦 由紀子、原田 仁、中川 暁雄、西 将康、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、鈴木 知志、掛地 吉弘

  第118回日本外科学会定期学術集会, 一般社団法人日本外科学会, 東京


• 当科における噴門部GISTの手術成績と治療戦略の検討

  池田 太郎、金治 新悟、長谷川 寛、山本 将士、松田 佳子、山下 公大、松田 武、押切 太郎、中村 哲、角 泰雄、鈴木 知志、掛地 吉弘

  第14回日本消化管学会総会学術集会, 一般社団法人日本消化管学会, 東京


• 進行胃癌に対する腹腔鏡下膵上縁郭清

  金治 新悟、鈴木 知志、池田 太郎、山本 将士、長谷川 寛、松田 佳子、山下 公大、松田 武、押切 太郎、角 泰雄、中村 哲、掛地 吉弘

  第30回日本内視鏡外科学会総会, 京都大学 医学部 消化管外科, 京都


• 術前化学放射線療法を施行した局所進行肛門管癌に対して有茎腹直筋皮弁再建が有用であった１例

  池田 太郎、松田 武、福岡 英志、長谷川 寛、山本 将士、金治 新悟、松田 佳子、山下 公大、押切 太郎、中村 哲、角 泰雄、鈴木 知志、掛地 吉弘

  第200回近畿外科学会, 京都府立医科大学 消化器外科, 京都


• Prone position in thoracoscopic esophagectomy improves postoperative oxygenation and reduces pulmonary complications

  Ikeda T, Nakamura T, Otsubo D, Yamamoto M, Kanaji S, Imanishi T, Oshikiri T, Sumi Y, Suzuki S, Kutoda D, Kakeji Y

  40th World Congress of the International College of Surgeons/62nd Annual Congress of the International College of Surgeons Japan Section(第40回国際外科学会・第62回国際外科学会日本部会総会), 国際外科学会、第４０回国際外科学会世界総会組織委員会、日本学術会議, 京都


• 腹臥位食道癌手術における左上縦隔郭清の定型化

  池田 太郎、押切 太郎、中村 哲、古出 隆大、山本 将士、長谷川 寛、金治 新悟、松田 佳子、山下 公大、松田 武、角 泰雄、鈴木 知志、掛地 吉弘

  第29回近畿内視鏡外科研究会, 関西医科大学 腎泌尿器外科学講座, 京都