研究活動情報

• Clinicopathological characteristics of neural epidermal growth factor-like 1 protein-associated membranous glomerulonephritis.

  Toshiki Hyodo, Shigeo Hara, Shunsuke Goto, Hideki Fujii, Shinichi Nishi, Akihiro Yoshimoto, Tomoo Itoh

  Neural epidermal growth factor-like 1 protein (NELL1) is the second most common target antigen in membranous glomerulonephritis (MGN). However, data regarding the clinicopathological characteristics of NELL1-associated MGN are limited owing to its low prevalence. This study examined the prevalence and clinicopathological characteristics of NELL1-associated MGN in a Japanese cohort. Additionally, we compared the clinicopathological features of NELL1-positive MGN, phospholipase A2 receptor 1 (PLA2R1)-positive MGN, and MGN negative for all three antigens (NELL1, PLA2R1, and thrombospondin type-1 domain-containing 7A). Among 257 consecutive patients pathologically diagnosed with MGN at two centers in Japan, 24 (9.3%) were immunohistochemically positive for NELL1. Clinically, patients with NELL1-positive MGN were significantly older (p < 0.001) and had a higher frequency of bucillamine use (vs PLA2R1-positive MGN, p < 0.01). Histologically, NELL1-positive MGN exhibited significantly lower detection of spikes and crater formation (p < 0.001), higher prevalence of segmental spike distribution (vs PLA2R1-positive MGN: p < 0.001), and higher prevalence of stage I cases on electron microscopy (p < 0.01). There were no significant differences in the prognoses among the three groups. The characteristic histological feature of segmental distribution in NELL1-positive MGN may be related to bucillamine use and the early phase of the disease. Further investigations with larger numbers of patients may offer further insight into the prognosis of patients with NELL1-positive MGN.

  2024年09月, Virchows Archiv : an international journal of pathology, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Immunohistological analysis reveals IgG1-dominant immunophenotype of tubulointerstitial nephritis unassociated with IgG4-related diseases.

  Toshiki Hyodo, Shigeo Hara, Shunsuke Goto, Hideki Fujii, Shinichi Nishi, Tomoko Horinouchi, Kandai Nozu, Norishige Yoshikawa, Akihiro Yoshimoto, Tomoo Itoh

  PURPOSE: Tubulointerstitial nephritis (TIN) has various etiologies, including IgG4-related disease (IgG4-RD), autoimmune diseases, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), and others. IgG4-positive plasma cell infiltration can occasionally be found in TIN unrelated to IgG4-RD. Therefore, there may be problems with usage of IgG4 immunostaining to differentiate between TIN with and TIN without IgG4-RD. This study aimed to compare the proportion of plasma cells that are positive for each IgG subclass and to clarify the predominant IgG subclass trends and clinical characteristics associated with IgG4-RD and non-IgG4-related interstitial nephritis. METHODS: The study enrolled 44 cases of TIN: 6 of IgG4-RD, 8 of autoimmune disease, 9 of AAV, and 21 of unknown disease group. In addition to clinical characteristics, IgG subclass composition of interstitial plasma cells was evaluated among 4 groups by immunohistochemistry. RESULTS: IgG1 was the predominant IgG subclass in TIN unrelated to IgG4-RD. In the IgG4-RD group, the IgG subclass rate was high in both IgG1 and IgG4. The rate of average IgG4-positive cells was significantly lower in the autoimmune disease group and unknown disease group compared with the IgG4-RD group. CONCLUSION: The present study revealed IgG1-dominant immune profiles of TIN unrelated to IgG4-RD. Further investigation is required to elucidate the clinicopathological differences between IgG1-dominant and IgG4-dominant groups in IgG4-RD.

  2024年02月, International urology and nephrology, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Association of CD4-positive cell infiltration with response to vedolizumab in patients with ulcerative colitis.

  Haruka Miyazaki, Namiko Hoshi, Tsukasa Ishida, Chiharu Nishioka, Sachiko Ouchi, Daisuke Shirasaka, Tomoo Yoshie, Yoshinori Munetomo, Yoshio Sakamoto, Tatsuya Osuga, Saori Matsui, Toshiki Hyodo, Tamami Denda, Daisuke Watanabe, Makoto Ooi, Yuzo Kodama

  Not all patients with ulcerative colitis (UC) respond initially to treatment with biologic agents, and predicting their efficacy prior to treatment is difficult. Vedolizumab, a humanized monoclonal antibody against alpha 4 beta 7 (α4β7) integrin, suppresses immune cell migration by blocking the interaction between α4β7 integrin and mucosal addressin cell adhesion molecule 1. Reports about histological features that predict vedolizumab efficacy are scarce. So, we examined the association between histological features and vedolizumab efficacy. This was a multicenter, retrospective study of patients with UC treated with vedolizumab. Biopsy specimens taken from the colonic mucosa prior to vedolizumab induction were used, and the areas positively stained for CD4, CD68, and CD45 were calculated. Clinical and histological features were compared between those with and without remission at week 22, and the factors associated with clinical outcomes were identified. We enrolled 42 patients. Patients with a high CD4+ infiltration showed a better response to vedolizumab [odds ratio (OR) = 1.44, P = 0.014]. The concomitant use of corticosteroids and high Mayo scores had a negative association with the vedolizumab response (OR = 0.11, P = 0.008 and OR = 0.50, P = 0.009, respectively). Histological evaluation for CD4+ cell infiltration may be helpful in selecting patients who can benefit from vedolizumab.

  2023年11月, Scientific reports, 13(1) (1), 20262 - 20262, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Renal cell carcinoma in the contralateral kidney with TFE3 gene translocation following chemotherapy for childhood nephroblastoma: A case report and literature review.

  Shunsuke Fujisawa, Junya Furukawa, Takuto Hara, Keiske Okada, Kouji Chiba, Yuzo Nakano, Toshiki Hyodo, Yoji Nagashima, Masato Fujisawa

  KEY CLINICAL MESSAGE: Renal cell carcinoma as a secondary malignant neoplasm is relatively rare; however, the possibility of secondary renal cell carcinoma following chemoradiotherapy for childhood nephroblastoma should be considered. ABSTRACT: The occurrence of secondary renal cell carcinoma (RCC) following chemoradiotherapy for nephroblastoma is relatively rare, especially in microphthalmia transcription factor family translocation renal cell carcinoma. A 13-year-old Japanese male was referred to our department for treatment of a right kidney mass. The patient had undergone open left nephrectomy and adjuvant chemotherapy for nephroblastoma, 12 years before. Diagnostic imaging revealed a tumor in the right kidney and a lesion suspected to be metastasis in the left eighth rib. Chromophobe RCC or translocation RCC was suspected from the imaging pattern. TNM classification was cT1aN0M1, and the clinical stage was IV. Partial nephrectomy by robot-assisted surgery for the right renal tumor and resection of the left eighth rib were performed. Pathologically, the renal tumor was diagnosed as translocation RCC, and the rib lesion demonstrated no evidence of malignancy. We are currently undergoing imaging follow-up and the patient has been recurrence-free for 15 months. In this study, we present a rare case of secondary translocation RCC after successful treatment of nephroblastoma.

  2023年11月, Clinical case reports, 11(11) (11), e8128, 英語, 国際誌

  神戸大学リポジトリ（Kernel）へのリンク


• COVID-19感染を契機にネフローゼ症候群を発症し,膜性増殖性糸球体腎炎(MGPN)と診断された1例

  黒野 博義, 渡邉 健太郎, 坂本 和雄, 河野 圭志, 後藤 俊介, 兵頭 俊紀, 藤井 秀毅

  (一社)日本腎臓学会, 2023年09月, 日本腎臓学会誌, 65(6-W) (6-W), 771 - 771, 日本語


• Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report.

  Takafumi Watanabe, Seitetsu Yoon, Kohei Yamakawa, Toshiki Hyodo, Kenta Izaki, Hirofumi Okada, Yutaka Shirakawa, Chikara Ebisutani, Yoshio Sakamoto, Shigeya Hirohata

  BACKGROUND Various neoplasms, including neuroendocrine neoplasms (NENs), can arise from the presacral space. Most presacral lesions are detected due to symptoms arising from tumor growth. However, diagnosing small, asymptomatic presacral tumors is challenging because of their unique location. CASE REPORT A 63-year-old woman with chronic hepatitis C underwent follow-up after achieving a sustained virological response. Abdominal ultrasonography revealed multiple new hyperechoic masses in the liver. Physical and laboratory examinations, including tumor marker analysis, yielded unremarkable results. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated metastatic liver tumors but failed to identify the primary site of these lesions. The hepatic mass was biopsied, leading to a diagnosis of grade 2 neuroendocrine tumor. 111In-pentetreotide somatostatin receptor scintigraphy revealed significant radiotracer accumulation in multiple hepatic masses, several bones, and a small presacral space lesion. Pathological examination of the presacral lesion confirmed a grade 2 neuroendocrine tumor, similar to the hepatic mass. Review of a CT scan performed 4 years earlier indicated a small cyst-like lesion in the presacral space suspected of being a developmental cyst; however, the presence of cystic components was not confirmed pathologically. The patient was diagnosed with a primary presacral neuroendocrine tumor, which might have originated from a developmental cyst, with multiple liver metastases. Chemotherapy with everolimus was initiated, and the clinical course has been uneventful. CONCLUSIONS We report a rare neuroendocrine tumor arising from the presacral space with multiple liver metastases. The presacral space should be examined when a NEN with an unknown primary site is found.

  2023年07月, The American journal of case reports, 24, e939614, 英語, 国際誌

  研究論文（学術雑誌）


• Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy.

  Takuto Hara, Tomoaki Terakawa, Toshiki Hyodo, Naoe Jinbo, Yuzo Nakano, Masato Fujisawa

  A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4.

  2021年11月, Urology case reports, 39, 101800 - 101800, 英語, 国際誌

  神戸大学リポジトリ（Kernel）へのリンク


• 播種性クリプトコッカス症を含む日和見感染症の原因と考えられたACTH産生下垂体腺腫を解剖にて同定しえた一例

  菅野 天裕, 神澤 真紀, 兵頭 俊紀, 近藤 武史, 三好 園子, 尾下 寿彦, 穂積 かおり, 神田 知紀, 福岡 秀規, 伊藤 智雄, 横崎 宏

  (株)文光堂, 2021年06月, 病理と臨床, 39(6) (6), 611 - 616, 日本語


• Pancreatic metastasis of renal cell carcinoma filling into the duct of Santorini.

  Yasutaka Yamada, Arata Sakai, Shohei Abe, Masanori Gonda, Takashi Kobayashi, Atsuhiro Masuda, Hideyuki Shiomi, Sachiyo Shirakawa, Hirochika Toyama, Toshiki Hyodo, Maki Kanzawa, Tomoo Itoh, Yuzo Kodama

  A 78-year-old man who underwent right nephrectomy for renal cell carcinoma (RCC) 18 years ago visited our hospital complaining of abdominal pain. Imaging revealed that the pancreatic head tumor obstructed the Santorini duct. We suspected a pancreatic intraductal tumor, such as an intraductal tubulopapillary neoplasm or intraductal papillary mucinous neoplasm. Thus, the patient underwent subtotal stomach-preserving pancreaticoduodenectomy. Pathological findings confirmed the diagnosis of metastatic RCC. Herein, we report a case of pancreatic metastasis of an RCC that presented with a tumor in the pancreatic duct.

  2021年06月, Clinical journal of gastroenterology, 14(3) (3), 905 - 909, 英語, 国内誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• An Incidental Diagnosis of Microscopic Renal Angiomyolipoma Completely Excised on Renal Biopsy: A Case Report.

  Toshiki Hyodo, Keiji Kono, Shinichi Nishi, Tomoo Itoh, Shigeo Hara

  BACKGROUND Microscopic tumor foci have been detected incidentally on renal biopsy, including renal cell carcinoma and renomedullary interstitial cell tumor (medullary fibroma). A report is presented of a case of an incidental finding of microscopic renal angiomyolipoma that was diagnosed and completely excised on core needle biopsy. CASE REPORT A 44-year-old woman was referred to our hospital for evaluation of persistent mild proteinuria. Three years previously, she was diagnosed with Cushing's syndrome associated with a right adrenal cortical adenoma, which was successfully treated with unilateral adrenalectomy. At the time of surgery, abdominal computed tomography (CT) showed no renal lesions. During the present admission, a renal biopsy was performed that showed minimal changes in the renal glomeruli and interstitium. Immunofluorescence showed weakly positive staining for IgM in the glomeruli and no dense deposits. A microscopic focus of a predominantly spindle-cell tumor was found in the corticomedullary region. Immunohistochemistry showed positive immunostaining for HMB-45, Melan-A, and alpha-smooth muscle actin (ASMA), which supported a diagnosis of angiomyolipoma. Abdominal ultrasound at one-year follow-up showed no evidence of residual renal tumor. CONCLUSIONS To our knowledge, this is the first reported case of a completely excised incidental microscopic renal angiomyolipoma. This case demonstrated that even when imaging findings are normal, renal biopsy may detect microscopic foci of primary renal tumors.

  2020年03月, The American journal of case reports, 21, e921353, 英語, 国際誌


• Clinicopathological characteristics of thrombospondin type 1 domain-containing 7A-associated membranous nephropathy.

  Shigeo Hara, Takahiro Tsuji, Yuichiro Fukasawa, Satoshi Hisano, Satoshi Morito, Toshiki Hyodo, Shunsuke Goto, Shinichi Nishi, Akihiro Yoshimoto, Tomoo Itoh

  Thrombospondin type 1 domain-containing 7A (THSD7A) is a recently identified target antigen of idiopathic membranous nephropathy (iMN). The clinicopathological characteristics of THSD7A-associated MN are poorly characterised due to low prevalence among MN patients. Among 469 consecutive cases of pathologically confirmed MN diagnosed at four centres in Japan, 14 cases were confirmed positive for THSD7A by immunohistochemistry (3.0%). The prevalence of THSD7A-associated MN tended to be higher in northern Japan. Most cases demonstrated nephrotic-range proteinuria (12/14 cases, 86%). In two patients, cancer was detected at the time of renal biopsy (small-cell carcinoma of the lung and prostatic adenocarcinoma with neuroendocrine differentiation). Both tumours were negative for THSD7A. Four patients had concurrent or previous incidence of allergic diseases, including one patient with Kimura's disease. Pathological analysis of kidney biopsy tissue revealed slight mesangial cell proliferation in three cases and spike formation in one case. Immunofluorescence studies demonstrated that IgG subclass was mainly IgG4-dominant/codominant (12/13, 92% cases), while the case with prostatic cancer had an IgG2-dominant distribution. The immunostaining profile for components of the lectin complement pathways was not significant in three cases including two patients with malignancy. One case was dual positive for THSD7A and PLA2R. Of 10 cases with known clinical follow-up data, 6 demonstrated reduced serum creatinine and 8 presented reduced proteinuria. In summary, although the major IgG phenotype was usually IgG4-dominant/codominant, clinical background was otherwise heterogeneous. Further investigation of regional differences in THSD7A-associated MN prevalence may reveal genetic and environmental risk factor and associated pathogenic mechanisms.

  2019年06月, Virchows Archiv : an international journal of pathology, 474(6) (6), 735 - 743, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• A case of membranous nephropathy characterized by atypical distribution of phospholipase A2 receptor .

  Toshiki Hyodo, Kei Saito, Keiji Kono, Shinichi Nishi, Tomoo Itoh, Shigeo Hara

  A 77-year-old man was referred to our hospital with persistent proteinuria and progressive lower leg edema. Past history was unremarkable except for hypertension. Autoimmune diseases, infections, and malignancies were excluded based on clinical and laboratory test results. Renal biopsy specimens showed membranous nephropathy with segmental distribution of spikes and bubbling appearance. Double contour formation in glomerular tufts was also observed. There were no proliferative changes in the glomeruli. Interstitial fibrosis and tubular atrophy were moderate, and no interstitial inflammation was observed. Arteries showed moderate sclerotic changes with hyalinosis. Immunohistochemical analysis revealed no thrombospondin type 1 domain-containing 7A reactivity. Immunofluorescence staining showed segmental granular positivity of IgG on glomerular tufts and focal staining of IgG on the tubular basement membranes. IgG deposits (subclass distribution: IgG1, 2+; IgG2, -; IgG3, 1+; IgG4, 2+) and phospholipase A2 receptor type 1 (PLA2R1) immunoreactivity showed similar distributions in both glomeruli and renal tubular basement membranes. Electron microscopy revealed subendothelial edema in partially collapsed glomerulus. No subepithelial dense deposits were observed in the glomeruli under an electron microscope. This is the first documented case of membranous nephropathy (MN) with segmental distribution of PLA2R1 in the glomeruli and focal PLA2R1 positivity in renal tubular basement membranes. Our findings extend the pathological presentation of PLA2R1-associated MN. Future studies are required to examine the mechanistic insights of these atypical histopathological features.
.

  2019年02月, Clinical nephrology, 91(2) (2), 114 - 119, 英語, 国際誌

  研究論文（学術雑誌）


• Chromophobe renal cell carcinoma with sarcomatoid differentiation containing various heterologous components.

  Toshiki Hyodo, Maki Kanzawa, Shigeo Hara, Kosuke Takahashi, Satoshi Ogawa, Junya Furukawa, Masato Fujisawa, Anna Kobayashi, Naoto Kuroda, Tomoo Itoh

  Renal cell carcinoma (RCC) occasionally has sarcomatoid differentiation and rarely contains heterologous components. We report a case of chromophobe RCC with sarcomatoid differentiation that had various heterologous components including a unique lipomatous area. The patient was an 83-year-old woman with a palpable mass in the left lower abdomen. Grossly, the tumor was 14 cm in diameter and had yellowish-to-whitish color with focal necrosis and hemorrhage. Histologically, the tumor was composed of an eosinophilic subtype of chromophobe RCC with sarcomatoid differentiation including mainly chondrosarcoma, some osteosarcoma and a lipomatous area. The heterologous components of sarcomatoid RCC are usually osteosarcoma or chondrosarcoma, and sarcomatoid RCC with multiple heterologous components is extremely rare.

  2018年09月, Pathology international, 68(9) (9), 524 - 529, 英語, 国際誌

  研究論文（学術雑誌）


• Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma

  Yasuko Hyogo, Naomi Kiyota, Naoki Otsuki, Shunsuke Goto, Yoshinori Imamura, Naoko Chayahara, Masanori Toyoda, Ken-ichi Nibu, Toshiki Hyodo, Shigeo Hara, Hiroo Masuoka, Toshihiko Kasahara, Yasuhiro Ito, Akihiro Miya, Mitsuyoshi Hirokawa, Akira Miyauchi, Hironobu Minami

  Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. In particular, proteinuria is thought to result from vascular endothelial damage and podocytopathy in glomeruli, and the development of thrombotic microangiopathy (TMA) has been reported for VEGF inhibitors. We encountered a patient with RAI-refractory (RR) papillary thyroid carcinoma (PTC) who developed proteinuria and renal dysfunction due to lenvatinib. Renal biopsy demonstrated that these changes were caused by TMA. To our knowledge, this is the first reported case of TMA due to lenvatinib in a Japanese patient with RR-PTC. A 70-year-old woman developed proteinuria, renal impairment and hypertension while receiving lenvatinib for RR-PTC. Her proteinuria and renal damage continued to worsen despite dose reductions and dose interruptions. Renal biopsy was consistent with the chronic type of TMA. These findings indicate that TMA is a possible cause of proteinuria due to lenvatinib, as has been reported for the VEGF inhibitors. (C) 2018 The Author(s) Published by S. Karger AG, Basel

  KARGER, 2018年, CASE REPORTS IN ONCOLOGY, 11(3) (3), 735 - 741, 英語

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク

• COVID-19感染を契機にネフローゼ症候群を発症し,膜性増殖性糸球体腎炎(MGPN)と診断された1例

  黒野 博義, 渡邉 健太郎, 坂本 和雄, 河野 圭志, 後藤 俊介, 兵頭 俊紀, 藤井 秀毅

  (一社)日本腎臓学会, 2023年09月, 日本腎臓学会誌, 65(6-W) (6-W), 771 - 771, 日本語


• COVID-19契機に非典型的溶血性尿毒症症候群(aHUS)を発症し維持透析に至った若年者の一例

  山本 真有佳, 天野 典彦, 兵頭 俊紀, 藤本 昌代, 小川 啓子, 加藤 陽子

  (一社)日本腎臓学会, 2023年09月, 日本腎臓学会誌, 65(6-W) (6-W), 773 - 773, 日本語


• 【病理診断クイックリファレンス 2023】(第9章)腎(非腫瘍) ループス腎炎

  兵頭 俊紀, 原 重雄

  (株)文光堂, 2023年04月, 病理と臨床, 41(臨増) (臨増), 133 - 133, 日本語


• 【病理診断クイックリファレンス 2023】(第9章)腎(非腫瘍) Alport症候群

  兵頭 俊紀, 原 重雄

  (株)文光堂, 2023年04月, 病理と臨床, 41(臨増) (臨増), 134 - 134, 日本語


• Renal medullary angiitis4例の臨床病理学的検討

  佐賀 信之, 兵頭 俊紀, 平社 亜沙子, 吉本 明弘, 西 愼一, 原 重雄, 伊藤 智雄

  (一社)日本病理学会, 2022年03月, 日本病理学会会誌, 111(1) (1), 213 - 214, 日本語


• 微小変化型ネフローゼ症候にみられるIgG dustingの検討

  山口 貴子, 兵頭 俊紀, 高橋 加奈, 西野 彰悟, 清水 祐里, 山下 大祐, 原 重雄

  (一社)日本病理学会, 2022年03月, 日本病理学会会誌, 111(1) (1), 338 - 338, 日本語


• 尿細管間質性腎炎55例の免疫組織化学染色を用いたIgG subclass検討

  兵頭 俊紀, 原 重雄, 後藤 俊介, 藤井 秀毅, 西 愼一, 野津 寛大, 吉川 徳茂, 吉本 明弘, 伊藤 智雄

  (一社)日本病理学会, 2022年03月, 日本病理学会会誌, 111(1) (1), 338 - 338, 日本語


• 母指指動脈の切断,吻合による再建が必要であった母指筋周皮腫の一例

  柏木瞭一郎, 野村正, 丸口勇人, 橋川和信, 寺師浩人, 兵頭俊紀

  2022年, 日本形成外科学会会誌, 42(4) (4)


• 難治性重症ネフローゼ症候群に対し免疫抑制療法と血漿交換により完全寛解に至ったSLEの一例

  川崎創, 金井大輔, 藤井秀毅, 渡邉健太郎, 河野圭志, 後藤俊介, 兵頭俊紀, 原重雄, 西慎一

  2021年, 日本腎臓学会誌(Web), 63(6-W) (6-W)


• Medullary angiitisと診断した腎膿瘍疑い症例

  安積陽也, 渡邉健太郎, 岡本英久, 横山直己, 兵頭俊紀, 石村武志, 原重雄, 河野圭志, 後藤俊介, 藤井秀毅, 西慎一

  2021年, 日本腎臓学会誌(Web), 63(6-W) (6-W)


• マクロクイズ 第144回

  兵頭俊紀, 黒田直人

  2021年, 病理と臨床, 39(4) (4)


• PTU服用開始9年後にANCA関連血管炎を発症した一例

  藤井 ゲンキ, 大西 諒子, 石田 育大, 前田 岳志, 樫谷 悠也, 芳村 魁, 稲山 由布子, 上田 真莉子, 石井 佳子, 中村 幸子, 日野 泰久, 兵頭 俊紀, 藤本 昌代, 飯田 啓二

  (一社)日本内分泌学会, 2020年10月, 日本内分泌学会雑誌, 96(2) (2), 513 - 513, 日本語


• Oligomeganephronia9例の臨床病理学的検討

  兵頭 俊紀, 西 愼一, 吉川 徳茂, 野津 寛大, 飯島 一誠, 原 重雄, 伊藤 智雄

  (一社)日本病理学会, 2020年03月, 日本病理学会会誌, 109(1) (1), 437 - 437, 日本語


• 肝細胞癌治療経過中に肝原発の神経内分泌癌を併発した症例

  戎谷 力, 尹 聖哲, 兵頭 俊紀, 渡部 貴文, 岡田 寛史, 白川 裕, さか本 喜雄, 廣畑 成也

  症例は68歳女性。XX-18年にC型肝硬変を指摘され保存的に治療されていた。XX-3年に肝細胞癌(hepatocellular carcinoma;HCC)を認め、合計3回のtransarterial chemoembolism;TACE、さらに腫瘍再発・門脈侵襲に対して放射線治療を施行。しかし治療反応性は乏しく腫瘍は急激に転移・増大した。XX年2月食道静脈瘤破裂による失血で死亡。病理解剖にてHCCは壊死しており、残存する腫瘍はすべて神経内分泌癌(neuroendocrine carcinoma;NEC)であった。治療を繰り返すうちにHCCがNECに転化、併存するようになったと思われる。既報告例ではfirst treatmentでHCCとNECの共存例ばかりであるが、本症例のように治療の経過中にHCCにNECが合併する症例はない。貴重な症例と考え報告する。(著者抄録)

  (一社)日本肝臓学会, 2020年03月, 肝臓, 61(3) (3), 122 - 128, 日本語


• Basedow病治療中にANCA関連血管炎を発症し,血管炎の病理所見を得た高齢女性の一例

  藤井研己, 大西諒子, 石田育大, 前田岳志, 樫谷悠也, 芳村魁, 稲山由布子, 上田真莉子, 石井佳子, 中村幸子, 日野泰久, 兵頭俊紀, 藤本昌代, 飯田啓二

  2020年, 日本内分泌学会雑誌, 96(4 (Web)) (4 (Web))


• 感染後糸球体腎炎を契機に発症した高齢者微小変化型ネフローゼ症候群のステロイド治療完全寛解症例

  加藤陽子, 渡邉美季, 小川啓子, 藤本昌代, 兵頭俊紀, 仲谷慎也, 武曽恵理, 石村栄治

  2020年, 日本腎臓学会誌(Web), 62(6) (6)


• Fabry病遺伝子変異と腎病理像 E66Q変異はFabry病か否か?

  兵頭 俊紀, 原 重雄, 藤井 秀毅, 西 愼一, 伊藤 智雄

  (一社)日本病理学会, 2019年04月, 日本病理学会会誌, 108(1) (1), 405 - 405, 日本語


• 痩せ型糖尿病と筋力低下から診断に至ったクッシング症候群の1例

  木戸希, 清家雅子, 大町侑香, 樫谷悠也, 稲山由布子, 立花真莉子, 伊藤潤, 中村幸子, 日野泰久, 田中宏和, 兵頭俊紀, 飯田啓二

  2019年, 日本内分泌学会雑誌, 95(1) (1)


• 腸間膜に発生した悪性末梢神経鞘腫の1例

  小林大悟, 木下知恵子, 伊崎健太, 酒井英郎, 高瀬至郎, 兵頭俊紀, 藤本昌代, 村上卓道

  2019年, 日本医学放射線学会秋季臨床大会抄録集, 55th


• 急速に健忘,意欲低下が進行した鞍上部血管腫の1例

  大町侑香, 伊藤潤, 木戸希, 樫谷悠也, 稲山由布子, 立花真莉子, 清家雅子, 中村幸子, 日野泰久, 相原英夫, 兵頭俊紀, 飯田啓二

  2019年, 日本内分泌学会雑誌, 95(1) (1)


• ゲフィチニブで治療中に急速進行性糸球体腎炎の経過を辿った肺がん患者の1例

  大西啓右, 西島陽子, 祖父江理, 串田吉生, 南野哲男, 兵頭俊紀

  2019年, 日本腎臓学会誌, 61(3) (3)


• 結晶様構造物を伴う近位尿細管障害像をきたした多発性骨髄腫の一例

  兵頭 俊紀, 原 重雄, 山本 侑毅, 藤田 直志, 北村 謙

  (一社)日本病理学会, 2018年04月, 日本病理学会会誌, 107(1) (1), 448 - 448, 日本語


• 皮膚筋炎の診断から発見に至った甲状腺乳頭癌の1例

  中村幸子, 大町侑香, 木戸希, 樫谷悠也, 稲山由布子, 立花真莉子, 伊藤潤, 清家雅子, 日野泰久, 兵頭俊紀, 飯田啓二

  2018年, 日本内分泌学会雑誌, 94(4 (Web)) (4 (Web))


• 乳癌の卵巣転移と原発性卵巣癌の鑑別が困難であった1症例

  佐古田洋子, 小林貴代, 石田泰, 藤本昌代, 兵頭俊紀, 田代敬

  2018年, 日本乳癌学会学術総会プログラム・抄録集, 26th


• 肝細胞癌治療経過中に神経内分泌癌を合併したC型肝硬変の一剖検例

  戎谷力, 尹聖哲, 渡部貴文, 岡田寛史, 白川裕, さか本喜雄, 廣畑成也, 兵頭俊紀

  2018年, 肝臓, 59(Supplement 3) (Supplement 3)

• 病理診断クイックリファレンス 2023/ 「病理と臨床」編集委員会編

  「病理と臨床」編集委員会, 大橋,健一

  文光堂, 2023年04月, 日本語


• 腎

  大橋, 健一(病理学), 小池, 淳樹, 冨田, 茂樹, 原, 重雄

  文光堂, 2022年11月, 日本語, ISBN: 9784830604881