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浦出 剛史医学部附属病院 肝胆膵外科助教
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■ 受賞- 2017年06月 第25回欧州内視鏡外科学会, ベストポスター賞, 3D Simulation and Intraoperative Ultrasonic Navigation for Laparoscopic Colorectal Surgery with Preservation of the Left Colic Artery
- 2014年12月 画論ザ・ベストイメージ2014東芝メディカルシステムズ, 特別賞, 術中超音波胆道造影が有用であった肝門部胆管癌の1例
- 2014年10月 第2回神緑会ヤングインベスティゲーターアワード, 最優秀賞, 術中超音波を駆使した新しい肝胆道手術ナビゲーション技術の開発
- PURPOSE: Surgeons' adaptability to robotic manipulation remains underexplored. This study evaluated the participants' first-touch robotic training skills using the hinotori surgical robot system and its simulator (hi-Sim) to assess adaptability. METHODS: We enrolled 11 robotic surgeons (RS), 13 laparoscopic surgeons (LS), and 15 novices (N). After tutorial and training, participants performed pegboard tasks, camera and clutch operations, energizing operations, and suture sponge tasks on hi-Sim. They also completed a suture ligation task using the hinotori surgical robot system on a suture simulator. Median scores and task completion times were compared. RESULTS: Pegboard task scores were 95.0%, 92.0%, and 91.5% for the RS, LS, and N groups, respectively, with differences between the RS group and LS and N groups. Camera and clutch operation scores were 93.1%, 49.7%, and 89.1%, respectively, showing differences between the RS group and LS and N groups. Energizing operation scores were 90.9%, 85.2%, and 95.0%, respectively, with a significant difference between the LS and N groups. Suture sponge task scores were 90.6%, 43.1%, and 46.2%, respectively, with differences between the RS group and LS and N groups. For the suture ligation task, completion times were 368 s, 666 s, and 1095 s, respectively, indicating differences among groups. Suture scores were 12, 10, and 7 points, respectively, with differences between the RS and N groups. CONCLUSION: First-touch simulator-based robotic skills were partially influenced by prior robotic surgical experience, while suturing skills were affected by overall surgical experience. Thus, robotic training programs should be tailored to individual adaptability.2024年11月, Langenbeck's archives of surgery, 409(1) (1), 332 - 332, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Systemic inflammation and altered metabolism are essential hallmarks of cancer. We hypothesized that the rapid turnover protein transthyretin (TTR) (half-life: 2-3 days), compared with the conventional marker albumin (21 days), better reflects the inflammatory/metabolic dynamics of pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant therapy (NAT) and is a useful prognostic marker. METHODS: Serum TTR and albumin levels were measured in 104 consecutive post-NAT PDAC patients before curative resection. The associations of preoperative TTR and albumin levels with overall survival (OS) after pancreatectomy were retrospectively analyzed. RESULTS: The mean (SD) TTR and albumin levels were 21.6 (6.4) mg/dL (normal range: ≥22.0 mg/dL) and 3.9 (0.55) g/dL. A low (<22.0 mg/dL) post-NAT TTR level was associated with an advanced tumor stage and higher CEA and CRP levels. Patients with low TTR levels showed significantly worse OS compared with normal levels (3-year OS 39 % vs. 54 %, P = 0.037), although albumin levels did not. We modified prognostic biomarkers of systemic inflammation/metabolism, such as GPS, PNI, and CONUT scores, using the serum TTR instead of albumin level and successfully showed that modified scores were better associated with OS compared with original scores using serum albumin level. CONCLUSIONS: Our data suggest that the TTR level is a promising prognostic biomarker for PDAC patients after NAT.2024年09月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 24(6) (6), 917 - 924, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The technical difficulties of laparoscopic liver resection (LLR) are greatly associated with the location of liver tumors. Since segment 8 (S8) contains a wide area, the difficulty of LLR for S8 tumors may vary depending on the location within the segment, such as the ventral (S8v) and dorsal (S8d) area, but the difference is unclear. METHODS: We retrospectively investigated 30 patients who underwent primary laparoscopic partial liver resection for liver tumors in S8 at Kobe University Hospital between January 2018 and June 2023. RESULTS: Thirteen and 17 patients underwent LLR for S8v and S8d, respectively. The operation time was significantly longer (S8v 203[135-259] vs. S8d 261[186-415] min, P = 0.002) and the amount of blood loss was significantly higher (10[10-150] vs. 10[10-200] mL, P = 0.034) in the S8d group than in the S8v group. No significant differences were observed in postoperative complications or postoperative length of hospital stay. Additionally, intraoperative findings revealed that the rate at which the case performed partial liver mobilization in the S8d group was higher (2[15.4%] vs. 8[47.1%], P = 0.060) and the median parenchymal transection time of the S8d group was longer (102[27-148] vs. 129[37-175] min, P = 0.097) than those in the S8v group, but there were no significant differences. CONCLUSION: The safety of LLR for the S8d was comparable to that of LLR for S8v, although LLR for S8d resulted in longer operative time and more blood loss. THE TRIAL REGISTRATION NUMBER: B230165 (approved at December 26, 2023).2024年08月, Langenbeck's archives of surgery, 409(1) (1), 243 - 243, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The impact of postoperative bile leak on the prognosis of patients with hepatocellular carcinoma who underwent liver resection is controversial. This study aimed to investigate the prognostic impact of bile leak for patients with hepatocellular carcinoma who underwent liver resection. METHODS: Patients with hepatocellular carcinoma who underwent liver resection between 2009 and 2019 at Kobe University Hospital and Hyogo Cancer Center were included. After propensity score matching between the bile leak and no bile leak groups, differences in 5-year recurrence-free and overall survival rates were evaluated using the Kaplan-Meier method. RESULTS: A total of 781 patients, including 43 with postoperative bile leak, were analyzed. In the matched cohort, 40 patients were included in each group. The 5-year recurrence-free survival rates after liver resection were 35% and 32% for the bile leak and no bile leak groups, respectively (P = 0.857). The 5-year overall survival rates were 44% and 54% for the bile leak and no bile leak groups, respectively (P = 0.216). CONCLUSION: Overall, bile leak may not have a profound negative impact on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.2024年07月, Langenbeck's archives of surgery, 409(1) (1), 233 - 233, 英語, 国際誌研究論文（学術雑誌）
- Tremelimumab plus durvalumab (Dur/Tre) is the first-line treatment for advanced hepatocellular carcinoma (HCC) worldwide. The present report describes the case of a 68-year-old man diagnosed with advanced HCC and a bile duct tumor thrombus (BDTT) who achieved a complete response to Dur/Tre therapy. The BDTT progressed to the bifurcation of the left and right hepatic ducts. Over time, both the tumors and BDTT progressively decreased in size, and a complete response was confirmed using the Response Evaluation Criteria in Solid Tumors (version 1.1.) 6 months after treatment administration. Subsequently, immune-related adverse events, including type 1 diabetes mellitus and diabetic ketoacidosis, emerged, leading to treatment discontinuation. The patient was undergoing outpatient follow-up in a drug-free state with no signs of recurrence 290 days after the initial administration of Dur/Tre. Although long-term and meticulous observations are required, the present findings could influence the choice of systemic chemotherapy for advanced HCC.2024年07月, Oncology letters, 28(1) (1), 332 - 332, 英語, 国際誌
- (一社)日本肝臓学会, 2024年05月, 肝臓, 65(5) (5), 256 - 257, 日本語急性肝不全患者に対する脳死肝移植待機中に腹直筋血腫を合併し管理に難渋した一例
- BACKGROUND/AIM: The treatment algorithm for systemic therapies for advanced hepatocellular carcinoma (HCC) has changed dramatically; however, the therapeutic landscape for sequential second-line or later-line treatments, including ramucirumab, remains controversial. This study aimed to investigate the role of ramucirumab for treating HCC. PATIENTS AND METHODS: We retrospectively analyzed data from 17 patients with advanced HCC who received ramucirumab, and 8 of them who received lenvatinib re-administration after ramucirumab treatment failure. RESULTS: The median overall survival of 17 patients treated with ramucirumab was 11.5 months. The median ratios of the 1-month post-treatment α-fetoprotein (AFP) levels and albumin-bilirubin (ALBI) scores to the pre-treatment AFP levels and ALBI scores following ramucirumab treatment were 0.880 and 0.965, respectively. The median ratios of the 1-month post-treatment AFP and ALBI levels to the pre-treatment levels were 1.587 and 0.970 for mALBI grade 1/2a, and 1.313 and 0.936 for mALBI grade 2b/3, respectively. Six of the eight patients who received lenvatinib rechallenge treatment exhibited a decrease in AFP levels one month post-lenvatinib treatment. Deterioration of liver function 3 months post-lenvatinib treatment was noted in five of the eight patients who received lenvatinib rechallenge treatment after ramucirumab. CONCLUSION: Ramucirumab may be equally useful in patients with unresectable HCC who have poor liver function or whose liver function is aggravated by other therapies. Rechallenge treatment with lenvatinib after ramucirumab may be a valid treatment option for HCC.2024年05月, Anticancer research, 44(5) (5), 2055 - 2061, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: This study aimed to evaluate the utility of the albumin-bilirubin grade for predicting the prognosis after repeat liver resection for patients with recurrent hepatocellular carcinoma. PATIENTS AND METHODS: Ninety patients with intrahepatic recurrent hepatocellular carcinoma who underwent repeat liver resection at our institution between 2005 and 2019 were retrospectively analyzed. Cox proportional-hazards regression models evaluated independent preoperative prognostic factors, including the albumin-bilirubin grade. Prognosis differences between patients with albumin-bilirubin grades 1 and 2 were analyzed using the Kaplan-Meier method. RESULTS: Cox proportional-hazards regression analysis revealed that albumin-bilirubin grade 2 (p=0.003) and early recurrence within one year from the initial surgery (p=0.001) were independently associated with poor recurrence-free survival, and albumin-bilirubin grade 2 (p=0.020) was independently associated with poor overall survival. The five-year recurrence-free (31% and 17%, respectively) and overall (86% and 60%, respectively) survival rates after repeat liver resection for patients with albumin-bilirubin grades 1 and 2 were significantly different between groups (both p=0.003). CONCLUSION: The albumin-bilirubin grade is useful for preoperatively predicting favorable survival rates after repeat liver resection for patients with recurrent hepatocellular carcinoma. Patients with an albumin-bilirubin grade 1 are better candidates for surgical treatment of recurrent hepatocellular carcinoma.2024年05月, Anticancer research, 44(5) (5), 2031 - 2038, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Drainage fluid amylase (DFA) is useful for predicting clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy (DP). However, difference in optimal cutoff value of DFA for predicting CR-POPF between open DP (ODP) and laparoscopic DP (LDP) has not been investigated. This study aimed to identify the optimal cutoff values of DFA for predicting CR-POPF after ODP and LDP. METHODS: Data for 294 patients (ODP, n = 127; LDP, n = 167) undergoing DP at Kobe University Hospital between 2010 and 2021 were reviewed. Propensity score matching was performed to minimize treatment selection bias. Receiver operating characteristic (ROC) analysis was performed to determine the optimal cutoff values of DFA for predicting CR-POPF for ODP and LDP. Logistic regression analysis for CR-POPF was performed to investigate the diagnostic value of DFA on postoperative day (POD) three with identified cutoff value. RESULTS: In the matched cohort, CR-POPF rates were 24.7% and 7.9% after ODP and LDP, respectively. DFA on POD one was significantly lower after ODP than after LDP (2263 U/L vs 4243 U/L, p < 0.001), while the difference was not significant on POD three (543 U/L vs 1221 U/L, p = 0.171). ROC analysis revealed that the optimal cutoff value of DFA on POD one and three for predicting CR-POPF were different between ODP and LDP (ODP, 3697 U/L on POD one, 1114 U/L on POD three; LDP, 10564 U/L on POD one, 6020 U/L on POD three). Multivariate analysis showed that DFA on POD three with identified cutoff value was the independent predictor for CR-POPF both for ODP and LDP. CONCLUSIONS: DFA on POD three is an independent predictor for CR-POPF after both ODP and LDP. However, the optimal cutoff value for it is significantly higher after LDP than after ODP. Optimal threshold of DFA for drain removal may be different between ODP and LDP.2024年03月, Surgical endoscopy, 38(5) (5), 2699 - 2708, 英語, 国際誌研究論文（学術雑誌）
- Spontaneous rupture of a primary hepatocellular carcinoma (HCC) is a frequently observed and fatal complication. However, the rupture of lymph node (LN) metastases from HCC is rare. A 79 year-old male with hepatitis B underwent three liver resections for HCC. Two years and 6 months after the last liver resection, enhanced computed tomography (CT) revealed a nodule with a diameter of 3 cm in the lower pole of the spleen. Splenic metastasis of HCC was suspected, and splenectomy was scheduled. During our hospital stay for a urinary tract infection before the scheduled operation, he complained of acute left-sided abdominal pain, and CT showed intra-abdominal hemorrhage due to rupture of the splenic tumor. Emergency splenectomy was performed, and the postoperative course was uneventful. Histopathological examination revealed a poorly differentiated HCC in the lower splenic pole lesion, which contained LN structures. The ruptured lesion was diagnosed as splenic hilar LN metastasis of HCC. Although laparoscopic partial liver resection was performed for intrahepatic recurrence, and atezolizumab plus bevacizumab therapy was administered for peritoneal metastases, the patient was alive 25 months after the splenectomy. Our case suggests that emergency surgery for LN metastatic rupture can achieve hemostasis and lead to improved survival outcomes.2024年02月, Clinical journal of gastroenterology, 17(3) (3), 557 - 562, 英語, 国内誌研究論文（学術雑誌）
- AIM: The IMbrave150 trial revealed that atezolizumab plus bevacizumab (AtezoBv) showed a higher objective response rate (ORR) in patients with advanced hepatocellular carcinoma (HCC). Although conversion therapy after AtezoBv has been recently reported, markers predictive of its efficacy, particularly radiological imaging markers, have not yet been identified. The present study focused on tumor morphological appearance on radiological imaging and evaluated whether it could be associated with AtezoBv efficacy. METHODS: Ninety-five intrahepatic lesions in 74 patients who were given AtezoBv for advanced HCC were recruited for evaluation. The lesions were divided into two groups, simple nodular (SN group) and non-simple nodular (non-SN group), based on the gross morphology on pretreatment imaging, and retrospectively evaluated for treatment response and other relevant clinical outcomes. RESULTS: Assessing the size of individual tumors after treatment, waterfall plots showed that tumor shrinkage in the non-SN group including 56 lesions was higher than that in the SN group comprising 39 lesions. The ORR was significantly higher in the non-SN group (39.3% vs. 15.4%, p = 0.012). Additionally, the median time to nodular progression was longer in the non-SN group (21.0 months vs. 8.1 months, p = 0.119) compared to the SN group. Six patients with non-SN lesions underwent sequential local therapy. CONCLUSIONS: Atezolizumab plus bevacizumab may show increased therapeutic efficacy in patients with tumors with a higher potential for aggressive oncological behavior, such as non-SN lesions. Treatment strategies focusing on conversion therapy may be crucial in patients with non-SN lesions.2024年02月, Hepatology research : the official journal of the Japan Society of Hepatology, 54(8) (8), 773 - 780, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Surgical resection is considered an effective cure for biliary tract cancer (BTC); however, the prognosis is unsatisfactory despite improved surgical techniques and perioperative management. The recurrence rate remains high even after curative resection. The efficacy of adjuvant chemotherapy in pancreatic and gastric cancers has been previously reported, and the feasibility of adjuvant therapy with S-1 has recently been reported in patients with resected BTC. We aimed to retrospectively investigate the effects of adjuvant chemotherapy with S-1 on resected advanced BTC. METHODS: We included data from 438 BTC patients who underwent resection between 2001 and 2020. After excluding patients with pTis-pT1 (n = 112) and other exclusion criteria, 266 patients were included in the analysis. RESULTS: After propensity score matching, 48 patients received S-1 adjuvant chemotherapy (S-1 group), and 48 patients received non-S1 adjuvant chemotherapy or underwent surgery alone (Non-S-1 group). The patients in the S-1 group had significantly better overall survival (OS) than those in the non-S-1 group (MST 51 vs 37 months, hazard ratio [HR]:.54, 95% confidence interval [CI]:.30-.98, P = .04). The S-1 group had a significantly better recurrence-free survival (RFS) than the non-S-1 group (94 vs 21 months, HR: .57, 95% CI: .33-.97, P = .03). Subgroup analyses for OS and RFS exhibited the benefits of S-1 in patients aged <75 years and in patients with primary sites of extrahepatic and perineural invasion and curability of R0. DISCUSSION: S-1 adjuvant therapy is promising for improving the postoperative survival of patients with resected advanced BTC, positive nerve invasion, and R0 resection.2024年01月, The American surgeon, 90(6) (6), 31348241227188 - 31348241227188, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Venous thromboembolism (VTE) is a potentially fatal complication of hepatectomy. The use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative bleeding. Therefore, we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after hepatectomy. AIM: To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after hepatectomy. METHODS: The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively analyzed. Patients were divided into two groups according to whether or not they developed VTE after hepatectomy, as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower extremities. Clinicopathological factors, including demographic data and perioperative D-dimer values, were compared between the two groups. Receiver operating characteristic curve analysis was performed to determine the D-dimer cutoff value. Univariate and multivariate analyses were performed using logistic regression analysis to identify significant predictors. RESULTS: In total, 234 patients who underwent hepatectomy were, of whom (5.6%) were diagnosed with VTE following hepatectomy. A comparison between the two groups showed significant differences in operative time (529 vs 403 min, P = 0.0274) and blood loss (530 vs 138 mL, P = 0.0067). The D-dimer levels on postoperative days (POD) 1, 3, 5, 7 were significantly higher in the VTE group than in the non-VTE group. In the multivariate analysis, intraoperative blood loss of > 275 mL [odds ratio (OR) = 5.32, 95% confidence interval (CI): 1.05-27.0, P = 0.044] and plasma D-dimer levels on POD 5 ≥ 21 μg/mL (OR = 10.1, 95%CI: 2.04-50.1, P = 0.0046) were independent risk factors for VTE after hepatectomy. CONCLUSION: Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the postoperative period.2024年01月, World journal of clinical cases, 12(2) (2), 276 - 284, 英語, 国際誌研究論文（学術雑誌）
- (株)北隆館, 2024年01月, BIO Clinica, 39(1) (1), 87 - 90, 日本語
- INTRODUCTION: The usefulness of gadolinium-ethoxybenzyl diethylenetriamine pentaacetate acid-enhanced magnetic resonance imaging (EOB-MRI) in assessing the functional future remnant liver volume (fFRLV) to predict post-hepatectomy liver failure (PHLF) has been previously reported. Herein, we evaluated the efficacy of this technique in patients with hepatocellular carcinoma (HCC) with a major portal vein tumor thrombus (PVTT). METHODS: This study included 21 patients with PVTT in the ipsilateral first-order branch (Vp3) and 30 patients with PVTT in the main trunk/contralateral branch (Vp4). To evaluate fFRLV, the signal intensity (SI) of the remnant liver was determined on T1-weighted images, using both conventional and newly developed methods. The fFRLV was calculated using the SI of the remnant liver and muscle, remnant liver volume, and body surface area. Preoperative factors predicting PHLF (≥grade B) in HCC patients with Vp3/4 PVTT were evaluated. RESULTS: In the Vp3 group, we found fFRLV area under the receiver-operating characteristic curves (AUCs) above 0.70 (AUC = 0.875, 0.750) using EOB-MRI results calculated using either the plot or whole method. None of the parameters in the Vp4 group had an AUC greater than 0.70. CONCLUSION: The fFRLV calculated by EOB-MRI using the whole method can be as useful as the conventional method in predicting PHLF (≥grade B) for HCC patients with Vp3 PVTT.2024年, Digestive surgery, 41(1) (1), 30 - 36, 英語, 国際誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2023年12月, 癌と化学療法, 50(13) (13), 1534 - 1536, 日本語
- (株)医薬情報研究所, 2023年11月, 新薬と臨牀, 72(11) (11), 955 - 955, 日本語
- An ischemia-reperfusion injury (IRI) results from a prolonged ischemic insult followed by the restoration of blood perfusion, being a common cause of morbidity and mortality, especially in liver transplantation. At the maximum of the potential damage, IRI is characterized by 2 main phases. The first is the ischemic phase, where the hypoxia and vascular stasis induces cell damage and the accumulation of damage-associated molecular patterns and cytokines. The second is the reperfusion phase, where the local sterile inflammatory response driven by innate immunity leads to a massive cell death and impaired liver functionality. The ischemic time becomes crucial in patients with underlying pathophysiological conditions. It is possible to compare this process to a shooting gun, where the loading trigger is the ischemia period and the firing shot is the reperfusion phase. In this optic, this article aims at reviewing the main ischemic events following the phases of the surgical timeline, considering the consequent reperfusion damage.2023年11月, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 29(11) (11), 1226 - 1233, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Postoperative cholangitis is a common complication of pancreaticoduodenectomy. Frequent cholangitis impairs patients' quality of life after pancreaticoduodenectomy. However, the risk factors for recurrence of cholangitis remain unclear. Hence, this retrospective study aimed to identify risk factors for recurrence of cholangitis after pancreaticoduodenectomy. METHODS: The medical records of patients who underwent pancreaticoduodenectomy between 2015 and 2019 in our institution were retrospectively reviewed. At least two episodes of cholangitis a year after pancreaticoduodenectomy were defined as 'recurrence of cholangitis' in the present study. Univariate and multivariate analyses were performed. RESULTS: The recurrence of cholangitis occurred in 40 of 207 patients (19.3%). Multivariate analysis revealed that internal stent (external, RR: 2.16, P = 0.026; none, RR: 4.76, P = 0.011), firm pancreas (RR: 2.61, P = 0.021), constipation (RR: 3.49, P = 0.008), and postoperative total bilirubin>1.7 mg/dL (RR: 2.94, P = 0.006) were risk factors of recurrence of cholangitis. Among patients with internal stents (n = 54), those with remnant stents beyond 5 months had more frequent recurrence of cholangitis (≥5 months, 75%; <5 months, 30%). CONCLUSIONS: Internal stents, firm pancreas, constipation, and postoperative high bilirubin levels are risk factors for cholangitis recurrence after pancreaticoduodenectomy. In addition, the long-term implantation of internal stents may trigger cholangitis recurrence.2023年10月, World journal of surgery, 47(10) (10), 2499 - 2506, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The Global Leadership Initiative on Malnutrition (GLIM), comprising several of the major global clinical nutrition societies, suggested the world's first criteria for diagnosis of the severity of malnutrition. However, the impact of the resulting diagnosis on patient outcomes for those with hepatocellular carcinoma (HCC) following liver resection (LR) has not been investigated. METHODS: A retrospective analysis of 293 patients with HCC who underwent LR between January 2011 and December 2018 was performed. We compared overall survival (OS) and recurrence-free survival (RFS) and evaluated prognostic factors after LR using Cox proportional hazards regression models. RESULTS: Preoperative patient nutritional status, n (%), was classified as follows: normal, 130 (44%), moderate malnutrition, 116 (40%), and severe malnutrition, 47 (16%). The median OS (129 vs. 43 months, p < 0.001) and median RFS (54 vs. 20 months, p = 0.001) were significantly greater in the normal group than in the severe malnutrition group. Multivariate analysis showed that severe malnutrition was a significant risk factor for OS (p = 0.006) and RFS (p = 0.010) after initial LR. CONCLUSION: Severe malnutrition, as diagnosed by the GLIM criteria, is a significant prognostic factor for survival and recurrence in patients with HCC after LR.2023年08月, HPB : the official journal of the International Hepato Pancreato Biliary Association, 25(12) (12), 1555 - 1565, 英語, 国際誌研究論文（学術雑誌）
- 2023年07月, Annals of surgical oncology, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Few reports have discussed the association between total tumor volume (TTV) and prognosis in patients with colorectal liver metastases (CRLM). The present study aimed to evaluate the usefulness of TTV for predicting recurrence-free survival and overall survival (OS) in patients receiving initial hepatic resection or chemotherapy, and to investigate the value of TTV as an indicator for optimal treatment selection for patients with CRLM. PATIENTS AND METHODS: This retrospective cohort study included patients with CRLM who underwent hepatic resection (n = 93) or chemotherapy (n = 78) at the Kobe University Hospital. TTV was measured using 3D construction software and computed tomography images. RESULTS: A TTV of 100 cm3 has been previously reported as a significant cut-off value for predicting OS of CRLM patients receiving initial hepatic resection. For patients receiving hepatic resection, the OS for those with a TTV ≥ 100 cm3 was significantly reduced compared with those with a TTV < 100 cm3. For patients receiving initial chemotherapy, there were no significant differences between the groups divided according to TTV cut-offs. Regarding OS of patients with TTV ≥ 100 cm3, there was no significant difference between hepatic resection and chemotherapy (p = 0.160). CONCLUSIONS: TTV can be a predictive factor of OS for hepatic resection, unlike for initial chemotherapy treatment. The lack of significant difference in OS for CRLM patients with TTV ≥ 100 cm3, regardless of initial treatment, suggests that chemotherapeutic intervention preceding hepatic resection may be indicated for such patients.2023年06月, Annals of surgical oncology, 30(11) (11), 6603 - 6610, 英語, 国際誌研究論文（学術雑誌）
- Transarterial chemoembolization (TACE) is performed for pancreatic neuroendocrine tumor (PanNEN) liver metastases; however, the safety and efficacy of TACE procedures, especially for patients who have undergone previous pancreatic surgery, have not been established. We reviewed 48 TACE procedures (1-6 procedures/patient) performed on 11 patients with PanNEN liver metastases, including 16 TACE procedures (4-6 procedures/patient) for 3 patients with a history of biliary-enteric anastomosis. The overall tumor objective response rate was 94%. The incidence of Clavien‒Dindo grade ≥ 2 complications was 1/16 (6%) and 1/32 (3%), and the median time to untreatable progression was 31 (14-41) and 27 (2-60) months among patients with and without a history of biliary-enteric anastomosis, respectively. Although validation is needed in future studies, our experiences have shown that TACE treatment is a viable treatment option for PanNEN liver metastases, even after biliary-enteric anastomosis with experienced teams and careful patient follow-up.2023年06月, Surgery today, 53(12) (12), 1396 - 1400, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Less intra-abdominal adhesions are expected following laparoscopic surgery. Although an initial laparoscopic approach for primary liver tumors may have advantages in patients who require repeat hepatectomies for recurrent liver tumors, this has not been sufficiently investigated. METHODS: Patients who underwent repeat hepatectomies for recurrent liver tumors at our hospital between 2010 and 2022 were retrospectively analyzed. Of 127 patients, 76 underwent laparoscopic repeat hepatectomy (LRH), of whom 34 patients initially underwent laparoscopic hepatectomy (L-LRH) and 42, open hepatectomy (O-LRH). Fifty-one patients underwent open hepatectomy as both the initial and second operation (O-ORH). We analyzed surgical outcomes between L-LRH and O-LRH groups and between L-LRH and O-ORH groups using propensity-matching analysis for each pattern. RESULTS: Twenty-one patients each were included in L-LRH and O-LRH propensity-matched cohorts. The L-LRH group had a lower rate of postoperative complications than the O-LRH group (0 vs 19%, P = 0.036). When we compared surgical outcomes between L-LRH and O-ORH groups in another matched cohort with 18 patients in each group, in addition to the lower rate of postoperative complications, the L-LRH group had additional favorable surgical outcomes including shorter operation time and lower blood loss volume than the O-ORH group (291 vs 368 min, P = 0.037 and 10 vs 485 mL, P < 0.0001). CONCLUSIONS: An initial laparoscopic approach would be favorable for patients undergoing repeat hepatectomies, as it leads to lower risk of postoperative complications. Compared with O-ORH, the advantage of the laparoscopic approach may be enhanced when it is repeatedly adopted.2023年06月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Recently, the Global Leadership Initiative on Malnutrition (GLIM), which includes the world's leading clinical nutrition societies, proposed the first global diagnostic criteria for malnutrition. However, the association between malnutrition diagnosed by the GLIM criteria and prognosis in patients with resected extrahepatic cholangiocarcinoma (ECC) remains unknown. This study aimed to investigate the predictive validity of the GLIM criteria for the prognosis of patients with resected ECC. PATIENTS AND METHODS: Between 2000 and 2020, 166 patients who underwent curative-intent resection for ECC were retrospectively analyzed. Prognostic significance of preoperative malnutrition diagnosed by the GLIM criteria was investigated using a multivariate Cox proportional hazards model. RESULTS: Eighty-five (51.2%) and 46 (27.7%) patients were diagnosed with moderate and severe malnutrition, respectively. Increased malnutrition severity tended to be correlated with increased lymph node metastasis rate (p-for-trend=0.0381). The severe malnutrition group had worse 1-, 3-, and 5-year overall survival rates than the normal (without malnutrition) group (82.2% vs. 91.2%, 45.6% vs. 65.1%, 29.3% vs. 61.5%, respectively, p=0.0159). In multivariate analysis, preoperative severe malnutrition was an independent predictor for poor prognosis (hazard ratio=1.68, 95% confidence interval=1.06-2.66, p=0.0282), along with intraoperative blood loss >1,000 ml, lymph node metastasis, perineural invasion, and curability. CONCLUSION: Severe preoperative malnutrition diagnosed by the GLIM criteria was associated with poor prognosis in patients who underwent curative-intent resection for ECC.2023年05月, Anticancer research, 43(5) (5), 2299 - 2308, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Post-transplantation weight control is important for long-term outcomes; however, few reports have examined postoperative weight change. This study aimed to identify perioperative factors contributing to post-transplantation weight change. METHODS: Twenty-nine patients who underwent liver transplantation between 2015 and 2019 with an overall survival of >3 years were analyzed. RESULTS: The median age, model for end-stage liver disease score, and preoperative body mass index (BMI) of the recipients were 57, 25, and 23.7, respectively. Although all but one recipient lost weight, the percentage of recipients who gained weight increased to 55% (1 month), 72% (6 months), and 83% (12 months). Among perioperative factors, recipient age ≤50 years and BMI ≤25 were identified as risk factors for weight gain within 12 months (P < .05), and patients with age ≤50 years or BMI ≤25 recipients gained weight more rapidly (P < .05). The recovery time of serum albumin level ≥4.0 mg/dL was not statistically different between the 2 groups. The weight change during the first 3 years after discharge was represented by an approximately straight line, with 18 and 11 recipients showing a positive and negative slope, respectively. Body mass index ≤23 was identified as a risk factor for a positive slope of weight gain (P <.05). CONCLUSIONS: Although postoperative weight gain implies recovery after transplantation, recipients with a lower preoperative BMI should strictly manage body weight as they may be at higher risk of rapid weight increase.2023年04月, Transplantation proceedings, 55(4) (4), 924 - 929, 英語, 国際誌研究論文（学術雑誌）
- Successful Management of Refractory Autoimmune Hemolytic Anemia with Cold Agglutinin Disease with Splenectomy: A Case Report with Review of Literature.BACKGROUND: Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia characterized by agglutination of red blood cells at temperatures below the normal core body temperature. In patients with CAD, splenectomy is not indicated because of its low therapeutic effect on hemolytic anemia induced by extravascular hemolysis. Herein, we report a case of refractory hemolytic anemia with CAD successfully managed with splenectomy. CLINICAL CASE: A 60-year-old man visited a municipal hospital with the chief complaint of fatigue. He was found to have hemolytic anemia and icterus with increased cold agglutination and was diagnosed with CAD. Malignant lymphoma was suspected as the underlying disease; however, no clear underlying disease was identified. Hemolytic anemia progressed during the subsequent winter seasons, and he was treated with temperature control, warming, and weekly blood transfusions. However, despite the blood transfusions, his hemoglobin level did not improve during the summer 2 years after diagnosis, and his previously observed splenomegaly had progressed. He was referred to our department, and a splenectomy was performed to diagnose any occult malignant lymphoma and improve the refractory hemolytic anemia. Because histopathological examination revealed no evidence of malignant lymphoma, a diagnosis of primary CAD was made. The hemolytic anemia improved, and no blood transfusion was required after splenectomy. CONCLUSIONS: Splenectomy significantly improved the patient's refractory hemolytic anemia due to primary CAD. Thus, it may be an effective treatment option in such cases, although further cases and studies are required to evaluate the effects of splenectomy.2023年01月, The Kobe journal of medical sciences, 68(1) (1), E30-E34, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Bile leakage is a major complication after liver transplantation and remains as a significant source of morbidity and mortality. In 2011, the International Study Group of Liver Surgery (ISGLS) defined bile leakage as a drain/serum bilirubin ratio ≥3. However, to our knowledge there is no literature assessing serum and drain bilirubin concentrations after liver transplantation. The aim of this study was to describe the natural postoperative changes in serum and drain fluid bilirubin concentrations in patients after liver transplantation. METHODS: We included 32 patients who underwent liver transplantation at Kobe University Hospital from January 2007 to December 2020. We enrolled 34 living donors who had no complications as the control group. RESULTS: The recipient serum total/direct bilirubin concentration were higher compared with the donors from postoperative day (POD) 1 to 5 with a statistical difference (P < .05). The recipient drain/serum total bilirubin ratio was lower than donors on POD 3 (0.89 ± 0.07 vs 1.53 ± 0.07: P < .0001), which was also confirmed by the recipient drain/serum direct bilirubin ratio (0.64 ± 0.10 vs 1.18 ± 0.09: P < .0001). On POD 3, the drain fluid volume (647.38 ± 89.47 vs 113.43 ± 86.8 mL: P < .001) and serum total bilirubin concentration (6.73 ± 0.61 vs 1.23 ± 0.60 mg/dL: P < .001) was higher in the recipients than in donors. Categorized in 2 groups, the higher drain fluid volume and bilirubin concentration recipients showed lower drain/serum total bilirubin ratio compared with the other group (P = .03) CONCLUSION: The drain/serum bilirubin ratio in the transplanted patients could be calculated lower compared with the hepatectomy patients because of high drain fluid volume and hyperbilirubinemia. Great care should be taken when assessing the bile leakage in liver transplant recipients using the ISGLS definition.2023年01月, Transplantation proceedings, 55(1) (1), 184 - 190, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Laparoscopic caudate lobe resection is a challenging procedure. Several researchers have reported the safety of laparoscopic liver resections;1.Transl Gastroenterol Hepatol. 1:56;2.Asian J Endosc Surg. 12:232-236;3.Ann Surg Oncol. 26:2980; however, a standardized procedure has not yet been established. Herein, we present a video showing laparoscopic Spiegel lobectomy in a patient with 6-cm hepatocellular carcinoma (HCC) using a novel approach. PATIENT AND METHODS: A 63-year-old man with a caudate lobe HCC was referred to our hospital. Computed tomography showed a 5 × 6 cm2 HCC located in the Spiegel lobe, which profoundly displaced the inferior vena cava (IVC) to the lower right side, and mobilization of the Spiegel lobe was considered difficult. To perform the dissection between the Siegel lobe and IVC safely, we performed parenchymal transection along the ventral side of the IVC initially. The Spiegel lobe was then dislocated to the left side of the IVC. We dissected the left lateral side of the IVC, including the proper hepatic vein draining the caudate lobe and the left IVC ligament with a safe operative field, and successfully removed the Spiegel lobe with large HCC. RESULTS: The operation time was 383 min. The blood loss was 10 mL. The patient was discharged on the seventh postoperative day without any complications. Histopathological examination revealed well-differentiated HCC with a negative surgical margin. CONCLUSIONS: Laparoscopic medial-to-lateral approach with initial parenchymal transection at the medial side of the Spiegel lobe followed by dissection of the left lateral side of the IVC is considered as a safe and effective procedure for large tumors in the Spiegel lobe.2023年01月, Annals of surgical oncology, 30(1) (1), 381 - 382, 英語, 国際誌研究論文（学術雑誌）
- 2023年01月, Annals of surgical oncology, 30(1) (1), 383 - 383, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: With the aging of the population in Japan, gallbladder cancer (GBC) in the elderly is increasing. However, the available clinical data are limited, and the optimal treatment is still controversial. The aim of this study was to evaluate the benefit of surgical resection in GBC patients ≥75 years of age. METHODS: A retrospective single center analysis of patients who had undergone surgical resection for GBC between 2000 and 2019 was carried out. Patients aged ≥75 years (elderly group, n = 24) or <75 years (younger group, n = 50) were compared. RESULTS: Both younger and elderly patients exhibited similar clinicopathological characteristics, but comorbidity in the latter was significantly greater, as was the frequency of less invasive surgery. Nonetheless, the incidence of postoperative complications was similar in elderly and younger patients. The proportion of patients receiving adjuvant chemotherapy was lower in the elderly. Overall survival of elderly and younger patients was not significantly different (65.0 vs 62.4% at 5 years, P = .600). In multivariate analysis, residual tumor status but not age was an independent prognostic factor. DISCUSSION: This study demonstrated that appropriate surgical treatment of elderly GBC patients was safe and effective, despite their having more comorbidities and lower rates of adjuvant chemotherapy than younger patients.2022年11月, The American surgeon, 89(12) (12), 31348221136570 - 31348221136570, 英語, 国際誌研究論文（学術雑誌）
- (株)医薬情報研究所, 2022年11月, 新薬と臨牀, 71(11) (11), 1234 - 1234, 日本語
- (株)医薬情報研究所, 2022年11月, 新薬と臨牀, 71(11) (11), 1234 - 1234, 日本語進行肝細胞癌におけるconversion surgeryの妥当性
- BACKGROUND: Anatomic liver resection (ALR) has been established to eliminate the tumor-bearing hepatic region with preservation of the remnant liver volume for liver malignancies. Recently, laparoscopic ALR has been widely applied; however, there are few reports on laparoscopic segmentectomy 2. This study aimed to present the standardization of laparoscopic segmentectomy 2 with surgical outcomes. METHODS: This study included seven patients who underwent pure laparoscopic segmentectomy 2 by the Glissonean approach from January 2020 to December 2021. Four of them had hepatocellular carcinoma, two had colorectal liver metastasis, and one had hepatic angiomyolipoma, which was preoperatively diagnosed with hepatocellular carcinoma. In all patients, preoperative three-dimensional (3D) simulation images from dynamic CT were reconstructed using a 3D workstation. The layer between the hepatic parenchyma and the Glissonean pedicle of segment 2 (G2) was dissected to encircle the root of G2. After clamping or ligation of the G2, 2.5 mg of indocyanine green was injected intravenously to identify the boundaries between segments 2 and 3 with a negative staining method under near-infrared light. Parenchymal transection was performed from the caudal side to the cranial side according to the demarcation on the liver surface, and the left hepatic vein was exposed on the cut surface if possible. RESULTS: The mean operative time for all patients was 281 min. The mean blood loss was 37 mL, and no transfusion was necessary. Estimated liver resection volumes significantly correlated with actual liver resection volumes (r = 0.61, P = 0.035). After the operation, one patient presented with asymptomatic deep venous and pulmonary thrombosis, which was treated with anticoagulant therapy. The mean length of hospital stay was 8.9 days. CONCLUSION: Laparoscopic segmentectomy 2 by the Glissonean approach is a feasible and safe procedure with the preservation of the nontumor-bearing segment 3 for liver tumors in segment 2.2022年11月, Surgical endoscopy, 36(11) (11), 8600 - 8606, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Atezolizumab plus bevacizumab and lenvatinib are the key drugs in the current systemic chemotherapeutic regimen for hepatocellular carcinoma (HCC). Studies have reported the potential effectiveness of lenvatinib introduction after an atezolizumab plus bevacizumab treatment; however, the therapeutic effectiveness of a lenvatinib rechallenge after an atezolizumab plus bevacizumab treatment remains unclear. PATIENTS AND METHODS: Thirteen consecutive patients who were rechallenged with lenvatinib after clinical failure following treatments with lenvatinib and atezolizumab plus bevacizumab were included. A comparative study was conducted on the duration and treatment efficacy of the first and second lenvatinib treatments and on the pre- and post-treatment liver function. RESULTS: The median ratios of the 1-month post-treatment alpha-fetoprotein (AFP) levels to the pretreatment AFP levels were 0.750 and 0.667 for the first and second lenvatinib treatments, respectively, without significant difference (p=0.9327). Meanwhile, the median ratios of the 1-month post-treatment albumin-bilirubin (ALBI) scores to the pretreatment ALBI scores were 1.063 and 0.827 for the first and second lenvatinib treatments, respectively, with significant difference (p=0.015). The median duration of the second lenvatinib treatment was significantly shorter than that of the first lenvatinib treatment [2.8 months (range=0.9-4.7 months) vs. 8.7 months (range=3.1-29.7 months)]. CONCLUSION: Lenvatinib re-administration after atezolizumab plus bevacizumab treatment can act as a double-edged sword, as it exerts an anti-tumor effect while being associated with potential liver function deterioration. However, this treatment sequence can be useful, and requires careful monitoring of the transitions in the liver function and the patient's performance status.2022年11月, Anticancer research, 42(11) (11), 5479 - 5486, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Resecting liver tumors located in Couinaud's segment VII is challenging; the efficacy and safety of laparoscopic liver resection for segment VII lesions compared to open liver resection remain unclear. METHODS: Medical records of 84 patients who underwent liver resection of segment VII at Kobe University Hospital and Hyogo Cancer Center between 2010 and 2021 were retrospectively analyzed. Surgical outcomes were compared between laparoscopic liver resection and open liver resection groups using propensity matching analysis. RESULTS: Thirty-one and 53 patients underwent laparoscopic liver resection and open liver resection, respectively. After propensity matching, 29 patients were included in each group. The laparoscopic liver resection group had a significantly longer operation time (407 vs. 305 min, P = 0.002), lower blood loss (100 vs. 230 mL, P = 0.004), and higher postoperative alanine aminotransferase levels (436 vs. 252 IU/L, P = 0.008) than the open liver resection group. In patients with liver cirrhosis, the proportion of patients with postoperative liver-specific complications was higher in the laparoscopic liver resection group than in the open liver resection group (57% vs 11%, P = 0.049), although there was no significant difference in postoperative liver-specific complication rates between the groups in patients without liver cirrhosis. CONCLUSIONS: For liver resection of segment VII, laparoscopic liver resection led to higher postoperative liver damage than open liver resection. Open liver resection may be better for patients with liver cirrhosis to avoid postoperative liver-specific complications. Laparoscopic liver resection could be an acceptable procedure for patients without liver cirrhosis, with some merits such as less blood loss.2022年11月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2274 - 2281, 英語, 国際誌研究論文（学術雑誌）
- Complete mesocolic excision (CME), which involves the adequate resection of the tumor-bearing colonic segment with "en bloc" removal of its mesocolon along embryological fascial planes is associated with superior oncological outcomes. However, CME presents a higher complication rate compared to non-CME resections due to a higher risk of vascular injury. Hyperspectral imaging (HSI) is a contrast-free optical imaging technology, which facilitates the quantitative imaging of physiological tissue parameters and the visualization of anatomical structures. This study evaluates the accuracy of HSI combined with deep learning (DL) to differentiate the colon and its mesenteric tissue from retroperitoneal tissue. In an animal study including 20 pig models, intraoperative hyperspectral images of the sigmoid colon, sigmoid mesentery, and retroperitoneum were recorded. A convolutional neural network (CNN) was trained to distinguish the two tissue classes using HSI data, validated with a leave-one-out cross-validation process. The overall recognition sensitivity of the tissues to be preserved (retroperitoneum) and the tissues to be resected (colon and mesentery) was 79.0 ± 21.0% and 86.0 ± 16.0%, respectively. Automatic classification based on HSI and CNNs is a promising tool to automatically, non-invasively, and objectively differentiate the colon and its mesentery from retroperitoneal tissue.2022年09月, Diagnostics (Basel, Switzerland), 12(9) (9), 英語, 国際誌研究論文（学術雑誌）
- Right-sided ligamentum teres (RSLT) is a rare congenital anomaly in which the fetal umbilical vein is connected to the right paramedian trunk of the portal vein. An 80-year-old woman underwent curative sigmoidectomy for sigmoid cancer 3 years prior to presentation. After 1 year, small solitary liver metastasis was noted in segment 4. Because the patient experienced recurrence of the same lesion after chemotherapy and radiofrequency ablation, she was referred to our hospital. CT revealed an anomaly of the liver with RSLT, classified as an independent posterior branch type. The tumor in the left paramedian section was located in the right umbilical portion (RUP), and BDTT was advanced to the common bile duct. Because the estimated future remnant liver volume was 35.2%, transileocecal portal vein embolization (PVE) for the portal branches from the RUP increased it to 43.5% in 3 weeks. Left trisectionectomy with extrahepatic bile duct resection and hepaticojejunostomy were performed. The patient was discharged on postoperative day 75. We successfully performed a left trisectionectomy after PVE in a patient with RSLT. Understanding the vascular and biliary anomalies of patients with RSLT is essential. When the future remnant liver is small, PVE can be considered for safe hepatectomy.Springer Science and Business Media LLC, 2022年09月, Clinical Journal of Gastroenterology, 15(6) (6), 1130 - 1135, 英語, 国内誌研究論文（学術雑誌）
- (一社)日本Acute Care Surgery学会, 2022年09月, Japanese Journal of Acute Care Surgery, 12(Suppl.) (Suppl.), 149 - 149, 日本語がん化学療法中の急性胆嚢炎症例の検討
- 2022年06月, Journal of the American College of Surgeons, 234(6) (6), 1262 - 1263, 英語, 国際誌研究論文（学術雑誌）
- 2022年05月, Journal of hepato-biliary-pancreatic sciences, 29(5) (5), e44-e45, 英語, 国内誌
- BACKGROUND: Optimal treatment strategies for advanced hepatocellular carcinoma (HCC) with macroscopic portal vein tumor thrombus (PVTT) remain controversial. Therefore, this study aimed to assess the impact and predictive factors of hepatectomy for HCC with macroscopic PVTT. METHODS: This study included 100 patients who presented with intraoperatively confirmed PVTT extending to the first portal branch (Vp3), main portal trunk, or opposite-side portal branch (Vp4) between June 2000 and December 2019. Their postoperative outcomes and predictive factors for survival were evaluated. RESULTS: Of the 100 patients, 37 (37%) and 63 (63%) had Vp3 and Vp4 PVTTs, respectively. Moreover, 42 (42%) and 58 (58%) patients underwent R0/1 and R2 hepatectomies, respectively. The median survival time (MST) of all patients with Vp3/4 PVTT was 14.5 months; the 1- and 3-year overall survival rates were 59.6 and 16.8%, respectively. The MSTs of patients with Vp3 and Vp4 PVTTs were 16.1 and 14.3 months, respectively (P = 0.7098). The MSTs of patients who underwent R0/1 and R2 hepatectomies were 14.3 and 14.9 months, respectively (P = 0.3831). All assessed tumor factors (including the Vp status [Vp3 or Vp4], type of resection [R0/1 or R2], intrahepatic maximal tumor size, intrahepatic tumor number, and the existence of extrahepatic metastasis) did not influence the overall survival significantly. CONCLUSIONS: Tumor factors, such as the presence of a Vp3/4 PVTT, have a strong impact on survival; however, other multiple tumor factors have a limited impact. Hepatectomy can be an effective treatment option for HCC with Vp3/4 PVTT, and its indications should be considered.2022年04月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(4) (4), 822 - 830, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma. METHODS: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019. The usefulness of the following inflammation-based scores as prognostic factor was investigated: Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), prognostic nutrition index (PNI), C-reactive protein to albumin ratio (CAR), controlling nutritional status (CONUT), and prognostic index (PI). RESULTS: A total of 169 patients were enrolled in this study. Of the nine scores, CAR and CONUT indicated prognostic value. Furthermore, multivariate analysis for overall survival revealed that high CAR (>0.23) was an independent prognostic factor (HR: 1.816, 95%CI: 1.135-2.906, p=0.0129), along with lymph node metastasis and curability. There was no difference in tumor staging and short-term outcomes between the low CAR (≤ 0.23) and high CAR groups. CONCLUSIONS: CAR was the most valuable prognostic score in patients with resected extrahepatic cholangiocarcinoma.2022年01月, Digestive surgery, 39(2-3) (2-3), 65 - 74, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The concept of minimally invasive anatomic liver resection (MIALR) is gaining popularity. However, specific technical skills need to be acquired to safely perform MIALR. The "Expert Consensus Meeting: Precision Anatomy for Minimally Invasive HBP Surgery (PAM-HBP Surgery Consensus)" was developed as a special program during the 32nd meeting of the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS). METHODS: Thirty-four international experts gathered online for the consensus. A Research Committee performed a comprehensive literature review, classifying studies according to the Scottish Intercollegiate Guidelines Network method. Based on the literature review and experts' opinions, tentative recommendations were drafted and circulated among experts using online Delphi Rounds. Finally, formulated recommendations were presented online in the Expert Consensus Meeting of the JSHBPS on February 23rd, 2021. The final recommendations were validated and finalized by the 2nd Delphi Round in May 2021. RESULTS: Seven clinical questions were selected, and 22 recommendations were formulated. All recommendations reached more than 85% consensus among experts at the final Delphi Round. CONCLUSIONS: The Expert Consensus Meeting for safely performing MIALR has presented a set of clinical guidelines based on available literature and experts' opinions. We expect these guidelines to have a favorable effect on the safe implementation and development of MIALR.2022年01月, Journal of hepato-biliary-pancreatic sciences, 29(1) (1), 16 - 32, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Although the number of minimally invasive liver resection (MILR) has been steadily increasing in many institutions, minimally invasive anatomic liver resection (MIALR) remains a complicated procedure that has not been standardized. We present the results of a survey among expert liver surgeons as a benchmark for standardizing MIALR. METHOD: We administered this survey to 34 expert liver surgeons who routinely perform MIALR. The survey contained questions on personal experience with liver resection, inflow/outflow control methods, and identification techniques of intersegmental/sectional planes (IPs). RESULTS: All 34 participants completed the survey; 24 experts (70%) had more than 11 years of experience with MILR, and over 80% of experts had performed over 100 open resections and MILRs each. Regarding the methods used for laparoscopic or robotic anatomic resection, the Glissonean approach (GA) was a more frequent procedure than the hilar approach (HA). Although hepatic veins were considered essential landmarks, the exposure methods varied. The top three techniques that the experts recommended for identifying IPs were creating a demarcation line, indocyanine green (ICG) negative staining method, and intraoperative ultrasound. CONCLUSION: MIALR remains a challenging procedure; however, a certain degree of consensus exists among expert liver surgeons.2022年01月, Journal of hepato-biliary-pancreatic sciences, 29(1) (1), 33 - 40, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: The Brisbane 2000 Terminology for Liver Anatomy and Resections, based on Couinaud's segments, did not address how to identify segmental borders and anatomic territories of less than one segment. Smaller anatomic resections including segmentectomies and subsegmentectomies, have not been well defined. The advent of minimally invasive liver resection has enhanced the possibilities of more precise resection due to a magnified view and reduced bleeding, and minimally invasive anatomic liver resection (MIALR) is becoming popular gradually. Therefore, there is a need for updating the Brisbane 2000 system, including anatomic segmentectomy or less. An online "Expert Consensus Meeting: Precision Anatomy for Minimally Invasive HBP Surgery (PAM-HBP Surgery Consensus)" was hosted on February 23, 2021. METHODS: The Steering Committee invited 34 international experts from around the world. The Expert Committee (EC) selected 12 questions and 2 future research topics in the terminology session. The EC created 7 tentative definitions and 5 recommendations based on the experts' opinions and the literature review performed by the Research Committee. Two Delphi Rounds finalized those definitions and recommendations. RESULTS: This paper presents 7 definitions and 5 recommendations regarding anatomic segmentectomy or less. In addition, two future research topics are discussed. CONCLUSIONS: The PAM-HBP Surgery Consensus has presented the Tokyo 2020 Terminology for Liver Anatomy and Resections. The terminology has added definitions of liver anatomy and resections that were not defined in the Brisbane 2000 system.2022年01月, Journal of hepato-biliary-pancreatic sciences, 29(1) (1), 6 - 15, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Although liver transplantation is widely accepted as the therapeutic strategy for end-stage liver failure, complication of hepatic venous outflow obstruction remains lethal. Currently, ensuring a single wide orifice in both the graft and recipient inferior vena cava has been proposed to avoid hepatic venous outflow obstruction with no theoretical concept. METHODS: We herein report a standardization technique for the reconstruction of the hepatic vein based on the causal analysis. RESULTS: During the put-in process, the graft must be positioned in contact with the recipient diaphragm and slightly pushed to the cranial direction to simulate the state after abdominal closure. Because there is no extra space between the graft and diaphragm, the graft could not rotate about the anastomotic site of the inferior vena cava toward the diaphragm after abdominal closure as the intestinal pressure increases, and accordingly hepatic venous outflow obstruction does not develop. CONCLUSIONS: With this concept, all transplant surgeons can successfully and easily perform hepatic vein reconstruction without total clamping of the inferior vena cava and without outflow block.2021年12月, Transplantation proceedings, 53(10) (10), 2934 - 2938, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Sarcopenia has been reported to be a significant prognostic factor in patients with hepatocellular carcinoma in recent years. This study aimed to clarify the prognostic significance of sarcopenia in advanced hepatocellular carcinoma treated with reductive hepatectomy. PATIENTS AND METHODS: We retrospectively analyzed 93 patients who underwent reductive hepatectomy for advanced hepatocellular carcinoma. RESULTS: Median survival time of the sarcopenia group (16.4 months) was significantly shorter than that of the non-sarcopenia group (20.4 months). The overall survival rates at 1, 3, and 5 years of the sarcopenia group were significantly lower than those of the non-sarcopenia group (57.9%, 8.6%, and 2.9% vs. 67.3%, 29.2%, and 15.7%, respectively; p=0.035). On multivariate analysis, sarcopenia was a significant risk factor of overall survival (hazard ratio=1.60, 95% confidence interval=1.00-2.56, p=0.049). CONCLUSION: Sarcopenia was a significant prognostic factor of survival after reductive hepatectomy in advanced hepatocellular carcinoma.2021年11月, Anticancer research, 41(11) (11), 5775 - 5783, 英語, 国際誌研究論文（学術雑誌）
- 2021年10月, Annals of surgery, 276(5) (5), e637-e638, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: While there is increasing evidence supporting the role of several first- and second-line treatment regimens for advanced hepatocellular carcinomas (HCC), the clinical relevance of rechallenge treatment with previously administered drugs, however, remains to be explored. PATIENTS AND METHODS: Five consecutive patients with advanced HCC who received lenvatinib rechallenge treatment after ramucirumab were assessed. RESULTS: All patients were clinically diagnosed with failure after ramucirumab treatment, and the frequencies of ramucirumab administration before lenvatinib re-administration ranged from 3 to 11. The alfa-fetoprotein level in four of five patients decreased 1 month after the lenvatinib rechallenge. Radiological findings via the modified Response Evaluation Criteria in Solid Tumors showed stable diseases in four patients and a partial response in one. CONCLUSION: Rechallenge treatment with lenvatinib after ramucirumab can be effective, and may be a treatment option for HCC in cases wherein the disease progressed after an initial response to lenvatinib treatment.2021年09月, Anticancer research, 41(9) (9), 4555 - 4562, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The critical view of safety (CVS) is poorly adopted in surgical practices although it is ubiquitously recommended to prevent major bile duct injuries during laparoscopic cholecystectomy (LC). This study aims to investigate whether performing a short intraoperative time out can improve CVS implementation. STUDY DESIGN: In this before versus after study, surgeons performing LCs at an academic center were invited to use a 5-second long time out to verify CVS before dividing the cystic duct (5-second rule). The primary aim was to compare the rate of CVS achievement for LCs performed in the year before versus the year after implementation of the 5-second rule. The CVS achievement rate was computed after exclusion of bailout procedures using a mediated video-based assessment made by two independent reviewers. Clinical outcomes, LC workflows, and postoperative reports were also compared. RESULTS: 343 of the 381 LCs performed between December 2017 and November 2019 (171 before and 172 after implementation of the 5-second rule) were analyzed. The 5-second rule was associated with a significantly increased rate of CVS achievement (15.9 vs. 44.1% before vs. after the 5-second rule, respectively; P<0.001). Significant differences were also observed with respect to the rate of bailout procedures (8.2 vs. 15.7%; P=0.04), the median [IQR] time to clip the cystic duct or artery (00:17:26 [00:11:48, 00:28:35] vs. 00:23:12 [00:14:29, 00:31:45] duration; P=0.007), and the rate of postoperative CVS reporting (1.3 vs. 28.8%; P<0.001). Postoperative morbidity was comparable (1.8 vs. 2.3%; P=0.68). CONCLUSION: Performing a short intraoperative time out was associated with an improved CVS achievement rate. Systematic intraoperative cognitive aids should be studied to sustain the uptake of guidelines.2021年07月, Journal of the American College of Surgeons, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To develop a computer vision platform to automatically locate critical events in surgical videos and provide short video clips documenting the critical view of safety (CVS) in laparoscopic cholecystectomy (LC). BACKGROUND: Intraoperative events are typically documented through operator-dictated reports that do not always translate the operative reality. Surgical videos provide complete information on surgical procedures, but the burden associated with storing and manually analyzing full-length videos has so far limited their effective use. METHODS: A computer vision platform named EndoDigest was developed and used to analyze LC videos. The mean absolute error (MAE) of the platform in automatically locating the manually annotated time of the cystic duct division in full-length videos was assessed. The relevance of the automatically extracted short video clips was evaluated by calculating the percentage of video clips in which the CVS was assessable by surgeons. RESULTS: 155 LC videos were analyzed: 55 of these videos were used to develop EndoDigest while the remaining 100 were used to test it. The time of the cystic duct division was automatically located with a MAE of 62.8 ± 130.4 seconds (1.95% of full-length video duration). CVS was assessable in 91% of the 2:30 minute long video clips automatically extracted from the considered test procedures. CONCLUSIONS: Deep learning models for workflow analysis can be used to reliably locate critical events in surgical videos and document CVS in LC. Further studies are needed to assess the clinical impact of surgical data science solutions for safer laparoscopic cholecystectomy.2021年07月, Annals of surgery, 274(1) (1), e93-e95, 英語, 国際誌研究論文（学術雑誌）
- Indication of Surgical Hepatectomy for the Patients of Hepatocellular Carcinoma with Inferior Vena Cava Tumor Thrombosis.The prognosis of hepatocellular carcinoma (HCC) presenting with inferior vena cava tumor thrombus (IVCTT) is extremely poor. The aim of this study was to reveal the postoperative course and to identify patients who have survived surgical hepatectomy among HCC patients with IVCTT. Between January 2006 and December 2018, 643 patients underwent surgical hepatectomy for HCC at Kobe University Hospital. Among them, 20 patients were categorized as Vv3 according to the Japanese staging system. We retrospectively collected detailed data on these patients. The statistical, clinical, and pathological data were recorded prospectively and analyzed retrospectively. The median survival time was 9.8 months. Among all patients, 11 (55%) achieved R0 resection, and only two survivors were from this group. The number of tumors (solitary vs. multiple; p=0.050) and pathological Vp (pVp0 vs. other; p=0.009) were identified as risk factors for overall survival in the univariate analysis. In the multivariate analysis, pathological Vp (pVp0 vs. other; p=0.037) was identified as a significant prognostic factor for survival. Pathological Vp affected overall survival among IVCTT patients; the median survival time was 53.7 months with pVp0, 10.2 months with pVp1, and 8.8 months with pVp2-4 (p=0.035). For patients with IVCTT, surgical hepatectomy should be indicated only for those who do not have portal vein invasion and could achieve R0 resection.2021年06月, The Kobe journal of medical sciences, 67(1) (1), E10-E17, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Clinical evaluation of the demarcation line separating ischemic from non-ischemic liver parenchyma may be challenging. Hyperspectral imaging (HSI) is a noninvasive imaging modality, which combines a camera with a spectroscope and allows quantitative imaging of tissue oxygenation. Our group developed a software to overlay HSI images onto the operative field, obtaining HSI-based enhanced reality (HYPER). The aim of the present study was to evaluate the accuracy of HYPER to identify the demarcation line after a left vascular inflow occlusion during an anatomical left hepatectomy. MATERIALS AND METHODS: In the porcine model (n = 3), the left branches of the hepatic pedicle were ligated. Before and after vascular occlusion, HSI images based on tissue oxygenation (StO2), obtained through the Near-Infrared index (NIR index), were regularly acquired and superimposed onto RGB video. The demarcation line was marked on the liver surface with electrocautery according to HYPER. Local lactates were measured on blood samples from the liver surface in both ischemic and perfused segments using a strip-based device. At the same areas, confocal endomicroscopy was performed. RESULTS: After ligation, HSI demonstrated a significantly lower oxygenation (NIR index) in the left medial lobe (LML) (0.27% ± 0.21) when compared to the right medial lobe (RML) (58.60% ± 12.08; p = 0.0015). Capillary lactates were significantly higher (3.07 mmol/L ± 0.84 vs. 1.33 ± 0.71 mmol/L; p = 0.0356) in the LML versus RML, respectively. Concordantly, confocal videos demonstrated the absence of blood flow in the LML and normal perfusion in the RML. CONCLUSIONS: HYPER has made it possible to correctly identify the demarcation line and quantify surface liver oxygenation. HYPER could be an intraoperative tool to guide perfusion-based demarcation line assessment and segmentation.2021年04月, Surgical endoscopy, 35(4) (4), 1844 - 1850, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: In this systematic review, we aimed to clarify the useful anatomic structures and assess available surgical techniques and strategies required to safely perform minimally invasive anatomic liver resection (MIALR), with a particular focus on the hepatic veins (HVs). METHODS: A systematic review was conducted using MEDLINE/PubMed for English articles and Ichushi databases for Japanese articles through September 2020. The quality assessment of the articles was performed in accordance with the Scottish Intercollegiate Guidelines Network (SIGN). RESULTS: A total of 3372 studies were obtained, and 59 were selected and reviewed. Due to the limited number of published comparative studies and case series, the degree of evidence from our review was low. Thirty-two articles examined the anatomic landmarks and crucial structures for approaching HVs. Regarding the direction of HV exposure, 32 articles focused on the techniques and advantages of exposing HVs from either the root or the periphery. Ten articles focused on the techniques to perform a segmentectomy 8 in particularly difficult cases of MIALR. In seven articles, bleeding control from HVs was also discussed. CONCLUSIONS: This review may help experts reach a consensus regarding the best approach to the management of hepatic veins during MIALR.2021年01月, Journal of hepato-biliary-pancreatic sciences, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was always associated with X-ray techniques. The aim of this study was to demonstrate the feasibility to navigate through the whole liver using an IVUSc, providing high-quality images and making it unnecessary to use ionizing radiation. METHODS: An ex vivo pig visceral block and an in vivo pig model were used in this study. The IVUS equipment was composed of an US system, and of an 8 French lateral firing IVUSc capable of producing 90-degree sector images in the longitudinal plane. After accessing the intravascular space with the IVUSc into the models, predetermined anatomical landmarks were visualized from the inferior vena cava and hepatic veins and corroborated. RESULTS: IVUS navigation was achieved in both models successfully. The entire navigation protocol took 87 and 48 min respectively, and 100% (21/21) and 96.15% (25/26) of the landmarks were correctly identified with the IVUSc alone in the ex vivo and in vivo models respectively. IVUS allowed to clearly visualize the vasculature beyond third-order branches of the hepatic and portal veins. CONCLUSIONS: A complete IVUS liver navigation is feasible using the IVUSc alone, making it unnecessary to use ionizing radiation. This approach provides high-definition and real-time images of the complex liver structure and offers a great potential for future clinical applications during diagnostic and therapeutic interventions.2021年01月, BMC gastroenterology, 21(1) (1), 24 - 24, 英語, 国際誌研究論文（学術雑誌）
- To reduce the risk of pancreatic fistula after pancreatectomy, a satisfactory blood flow at the pancreatic stump is considered crucial. Our group has developed and validated a real-time computational imaging analysis of tissue perfusion, using fluorescence imaging, the fluorescence-based enhanced reality (FLER). Hyperspectral imaging (HSI) is another emerging technology, which provides tissue-specific spectral signatures, allowing for perfusion quantification. Both imaging modalities were employed to estimate perfusion in a porcine model of partial pancreatic ischemia. Perfusion quantification was assessed using the metrics of both imaging modalities (slope of the time to reach maximum fluorescence intensity and tissue oxygen saturation (StO2), for FLER and HSI, respectively). We found that the HSI-StO2 and the FLER slope were statistically correlated using the Spearman analysis (R = 0.697; p = 0.013). Local capillary lactate values were statistically correlated to the HSI-StO2 and to the FLER slope (R = -0.88; p < 0.001 and R = -0.608; p = 0.0074). HSI-based and FLER-based lactate prediction models had statistically similar predictive abilities (p = 0.112). Both modalities are promising to assess real-time pancreatic perfusion. Clinical translation in human pancreatic surgery is currently underway.2021年01月, Diagnostics (Basel, Switzerland), 11(1) (1), 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To develop a deep learning model to automatically segment hepatocystic anatomy and assess the criteria defining the critical view of safety (CVS) in laparoscopic cholecystectomy (LC). BACKGROUND: Poor implementation and subjective interpretation of CVS contributes to the stable rates of bile duct injuries in LC. As CVS is assessed visually, this task can be automated by using computer vision, an area of artificial intelligence aimed at interpreting images. METHODS: Still images from LC videos were annotated with CVS criteria and hepatocystic anatomy segmentation. A deep neural network comprising a segmentation model to highlight hepatocystic anatomy and a classification model to predict CVS criteria achievement was trained and tested using 5-fold cross validation. Intersection over union, average precision, and balanced accuracy were computed to evaluate the model performance versus the annotated ground truth. RESULTS: A total of 2854 images from 201 LC videos were annotated and 402 images were further segmented. Mean intersection over union for segmentation was 66.6%. The model assessed the achievement of CVS criteria with a mean average precision and balanced accuracy of 71.9% and 71.4%, respectively. CONCLUSIONS: Deep learning algorithms can be trained to reliably segment hepatocystic anatomy and assess CVS criteria in still laparoscopic images. Surgical-technical partnerships should be encouraged to develop and evaluate deep learning models to improve surgical safety.2020年11月, Annals of surgery, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Three-dimensional (3-D) high-definition (HD) stereovision and two-dimensional (2-D) ultra-high-resolution (4K) monitors have recently become available for laparoscopic surgery. The aim of this study was to compare laparoscopic performance between inexperienced participants using 3-D/HD and 2-D/4K monitors and those using conventional 2-D/HD monitors. METHODS: The study enrolled 66 participants with no previous surgical experience or medical training. They were randomly divided into three equal groups, each using a different type of monitor (2-D/HD, 2-D/4K, or 3-D/HD), to perform three phantom tasks using a laparoscopic simulator: Task 1, touching markers on a non-flat surface; Task 2, bimanual peg transfer; and Task 3, passing a straight rod through a loop. Each task was performed three times. The performance scores (operative time, path length of the forceps, and technical errors) were compared for each monitor type and by age group (< 30 vs. > 30 years). RESULTS: For all three tasks, scores using the 3-D monitor were significantly better than those using either 2-D monitor, with no difference between the 2-D/4K and 2-D/HD monitors. Using the 2-D monitors, the performance of Task 3 by the participants > 30 years was worse than that by the younger participants; however, there was no difference between the age groups when using the 3-D monitor. CONCLUSION: Participants with no prior experience using a 3-D monitor showed better laparoscopic performance than those using 2-D monitors, even with 4K resolution. This improvement was more marked in older participants, suggesting a greater loss of depth perception in a 2-D environment.2020年11月, Surgical endoscopy, 34(11) (11), 5083 - 5091, 英語, 国際誌研究論文（学術雑誌）
- Anatomical liver resection (ALR) is the preferred oncological approach for the treatment of primary liver malignancies, such as hepatocellular carcinoma and intrahepatic cholangiocarcinoma. The demarcation line (DL) is formed by means of selective vascular occlusion and is used by surgeons to guide ALR. Emerging intraoperative technologies are playing a major role to enhance the surgeon's vision and ensure a precise oncologic surgery. In this article, a brief overview of modalities to assess the DL during ALRs is presented, from the established conventional techniques to future perspectives.2020年10月, Surgical innovation, 27(5) (5), 424 - 430, 英語, 国際誌研究論文（学術雑誌）
- 大道学館出版部, 2020年07月, 臨牀と研究, 97(7) (7), 894 - 896, 日本語
- BACKGROUND: In laparoscopic cholecystectomy (LC), achievement of the Critical View of Safety (CVS) is commonly advocated to prevent bile duct injuries (BDI). However, BDI rates remain stable, probably due to inconsistent application or a poor understanding of CVS as well as unreliable reporting. Objective video reporting could serve for quality auditing and help generate consistent datasets for deep learning models aimed at intraoperative assistance. In this study, we develop and test a method to report CVS using videos. METHOD: LC videos performed at our institution were retrieved and the video segments starting 60 s prior to the division of cystic structures were edited. Two independent reviewers assessed CVS using an adaptation of the doublet view 6-point scale and a novel binary method in which each criterion is considered either achieved or not. Feasibility to assess CVS in the edited video clips and inter-rater agreements were evaluated. RESULTS: CVS was attempted in 78 out of the 100 LC videos retrieved. CVS was assessable in 100% of the 60-s video clips. After mediation, CVS was achieved in 32/78(41.03%). Kappa scores of inter-rater agreements using the doublet view versus the binary assessment were as follows: 0.54 versus 0.75 for CVS achievement, 0.45 versus 0.62 for the dissection of the hepatocystic triangle, 0.36 versus 0.77 for the exposure of the lower part of the cystic plate, and 0.48 versus 0.79 for the 2 structures connected to the gallbladder. CONCLUSIONS: The present study is the first to formalize a reproducible method for objective video reporting of CVS in LC. Minute-long video clips provide information on CVS and binary assessment yields a higher inter-rater agreement than previously used methods. These results offer an easy-to-implement strategy for objective video reporting of CVS, which could be used for quality auditing, scientific communication, and development of deep learning models for intraoperative guidance.2020年06月, Surgical endoscopy, 34(6) (6), 2709 - 2714, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Anatomical liver resections guided by a demarcation line after portal staining or inflow clamping of the target area have been established as essential methods for curative treatment of hepatocellular carcinoma (HCC) and have subsequently been applied to other malignancies. However, laparoscopic anatomical liver resection (LALR) procedures are very difficult to reproduce, and the confirmation of demarcation of the hepatic segment on a monitor is also challenging. Recently, indocyanine green (ICG) fluorescence imaging has been used to identify hepatic tumors and segmental boundaries during hepatectomy. Herein, we describe LALR using ICG fluorescence imaging. METHODS: Three patients underwent pure LALR using ICG fluorescence imaging at our institute. One patient underwent anatomical partial liver resection for HCC, another underwent segmentectomy 3 for metastatic liver cancer, and the third underwent right anterior sectionectomy for HCC. To visualize hepatic perfusion and the demarcation line by negative staining using an optical imaging system, 2.5 mg ICG was injected intravenously during surgery following clamping or closure of the proximal Glissonean pedicles. RESULTS: For all three cases, ICG fluorescent imaging clearly delineated the demarcation lines and allowed identification of intersegmental planes to some extent because the tumor-bearing hepatic region became non-fluorescing parenchyma during parenchymal transection. This allowed surgeons to recognize the direction and guide the transection of the liver parenchyma when performing LALR. CONCLUSION: LALR using ICG fluorescence imaging is a feasible procedure for resection of the tumor-bearing hepatic region and facilitates visualization of the demarcation line and identification of the boundaries of the hepatic sections.2020年01月, Asian journal of surgery, 43(1) (1), 362 - 368, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The use of surgical metal clips is crucial for ligating vessels in various operations. The currently available metal clips have several drawbacks; they are permanent and interfere with imaging techniques such as computed tomography (CT) or magnetic resonance (MR) imaging and carry the potential risk of endo-clip migration. We recently developed a novel magnesium (Mg) alloy for biodegradable clips that reduces artifacts on CT imaging. This study aimed to examine the tolerance, biodegradability, and biocompatibility of the Mg alloy clips compared with those of standard titanium (Ti) clips in hepatectomy. METHODS: Thirty Wistar rats were divided into two groups based on the clip used (groups A and B). The vascular pedicle, including hepatic artery, portal vein, bile duct, and hepatic vein of the left lateral lobe, was ligated with the Ti clip in group A or the Mg alloy clip in group B, and then the left lateral lobe was removed. The rats were sacrificed at 1, 4, 12, 24, and 36 weeks after surgery. Clinical and histological evaluations were performed. Absorption rate was calculated by measuring the clip volume. RESULTS: Although the Mg alloy clips showed biodegradability over time, there were no significant differences in the serum concentration of Mg between the two groups. The remaining volume ratio of Mg alloy clips was 95.5, 94.3, 80.0, 36.2, and 16.7% at 1, 4, 12, 24, and 36 weeks, respectively. No side effects occurred. Most of the microscopic changes were similar in both groups. CONCLUSIONS: The new biodegradable Mg alloy clips are safe and feasible in vessel ligation for hepatectomy in a rat model and reduce artifacts in CT imaging compared with the standard Ti clips.2019年09月, BMC surgery, 19(1) (1), 130 - 130, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Hepatocellular adenoma (HCA) is a rare liver tumor that has the potential for rupture and malignant transformation. Here, we report a case of multiple hepatocellular adenomas (HCAs) that were treated by surgical resection. CASE PRESENTATION: An 18-year-old man was admitted to our hospital with proteinuria. His height was 176.5 cm, weight was 126 kg, and body mass index was 40 kg/m2. A liver tumor was incidentally found on abdominal ultrasonography. Contrast-enhanced computed tomography and gadoxetic acid-enhanced magnetic resonance imaging revealed three hepatic tumors that were 68 mm, 16 mm, and 9 mm in segments 3/4, 8, and 1, respectively. A percutaneous needle biopsy of the largest tumor was performed, the diagnosis of unclassified type HCA was made, and laparoscopic partial liver resection was performed of all three. The postoperative course was uneventful, and the patient was discharged 12 days later. An immunohistochemical examination revealed positivity for serum amyloid A protein, no decrease in fatty acid-binding protein, and negativity for β-catenin, glutamine synthetase, and cytokeratin 7. Therefore, these tumors were diagnosed as inflammatory type HCAs. CONCLUSIONS: We reported an extremely rare case of multiple resected HCAs in a young, obese Japanese man. Our findings suggest that HCA should be considered in the differential diagnosis of liver tumor in obese patients. Further studies that consider clinical and molecular risk factors are required to establish individualized treatment plans for HCA in obese patients.2019年08月, Surgical case reports, 5(1) (1), 131 - 131, 英語, 国際誌研究論文（学術雑誌）
- (株)北隆館, 2019年07月, BIO Clinica, 34(7) (7), 691 - 696, 日本語【肝炎・肝癌】肝細胞癌に対する外科治療の最前線
- Gallbladder metastasis from breast cancer, especially from ductal carcinoma, is rare. Herein, we report a rare case of gallbladder metastasis from ductal carcinoma of the breast that was diagnosed after laparoscopic cholecystectomy (LC) for acute cholecystitis. A 78-year-old woman presented with right upper abdominal tenderness and positive Murphy's sign during chemotherapy for advanced multiple metastases of the breast cancer. Abdominal ultrasonography and computed tomography showed a slightly thickened gallbladder wall and two calculi. After a diagnosis of acute calculous cholecystitis was established, LC was performed. Pathological examination revealed poorly differentiated adenocarcinoma infiltrating the submucosal and subserosal layer over the entire gallbladder, and a lymph node metastasis in the gallbladder neck. Immunohistochemical examination revealed that the tumor cells tested positive for estrogen receptor and negative for progesterone receptor, which was consistent with primary breast cancer. The patient was uneventfully discharged without abdominal pain 7 days later. Although she subsequently underwent several chemotherapies, she died 16 months later. In conclusion, gallbladder metastasis should be considered in patients with multiple metastatic breast cancer who present with signs or symptoms of cholecystitis. Moreover, LC should be considered to relieve the symptoms of cholecystitis for improved prognosis, even in a patient with multiple metastases.2019年02月, Clinical journal of gastroenterology, 12(1) (1), 52 - 56, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Many surgical techniques have been developed to treat inguinal hernia. In recent years, the laparoscopic transabdominal preperitoneal (TAPP) approach has been widely performed to repair inguinal hernia. Giant inguinal hernia (GIH) is an extremely rare disease that is a challenge for general surgeons. GIH appears when patients neglect the treatment for many years and it is defined as an inguinal hernia that extends below the midpoint of inner thigh in standing position. According to previous publications, the Lichtenstein tension-free hernioplasty is recommended to repair GIH. In this article, we describe consecutive four cases of GIH repaired via the TAPP approach. METHODS: From April 2015 to March 2017, 200 patients underwent hernioplasty against inguinal hernia at our hospital. Inguinal hernias were treated via the TAPP approach in principle. We performed hernioplasty via the TAPP approach in all 4 patients (2%) who met the definition of Type 1 GIH. Demographic information, maximum diameter of hernia sac, hernia orifice size, and surgical data were obtained. RESULTS: The mean operative time was 135 min. No intraoperative complications were encountered. All patients could walk from postoperative day 1 and were discharged home early, but they all had scrotal seromas. Three patients did not need puncture or drainage, but one of them required puncture. All seromas disappeared within 6 months. There was no recurrence in the 8- to 24-month follow-up. CONCLUSION: The TAPP approach is a feasible, safe therapeutic option that may reduce wound size and pain following surgical treatment of Type 1 GIH.2019年01月, Asian journal of surgery, 42(1) (1), 414 - 419, 英語, 国際誌研究論文（学術雑誌）
- (株)医薬情報研究所, 2018年12月, 新薬と臨牀, 67(12) (12), 1531 - 1531, 日本語
- Omental abscess due to a spilled gallstone is extremely rare after laparoscopic cholecystectomy. Herein, we report a 68-year-old man who presented with left upper abdominal pain after laparoscopic cholecystectomy for gangrenous cholecystitis. Seven months prior to admission, gallbladder perforation with spillage of pigment gallstones and bile occurred during laparoscopic cholecystectomy. The spilled gallstones were retrieved through vigorous peritoneal lavage. Abdominal computed tomography showed a 3 × 2.5 cm intra-abdominal heterogeneous mass, suspected to be an omental abscess, and ascites around the spleen. Exploratory laparoscopy revealed an inflammatory mass within the greater omentum. Laparoscopic partial omentectomy and abscess drainage were performed, and a small black pigment gallstone was unexpectedly found in the whitish abscess fluid. Abscess fluid culture results were positive for extended-spectrum β-lactamase-producing Escherichia coli and Streptococcus salivarius, which were previously detected in the gangrenous gallbladder abscess. The histopathological diagnosis was abscess in the greater omentum. Postoperative course was uneventful, and the patient was discharged 13 days later. In conclusion, we report a successful case of laparoscopic management of an omental abscess due to a spilled gallstone after LC. It is important to attempt to retrieve spilled gallstones during LC because they may occasionally result in serious complications.2018年10月, Clinical journal of gastroenterology, 11(5) (5), 433 - 436, 英語, 国内誌研究論文（学術雑誌）
- 2018年09月, Techniques in coloproctology, 22(9) (9), 703 - 708, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本内視鏡外科学会, 2018年07月, 日本内視鏡外科学会雑誌, 23(4) (4), 545 - 550, 日本語
- 日本臨床外科学会, 2018年03月, 日本臨床外科学会雑誌, 79(3) (3), 554 - 559, 日本語
- 2018年02月, Canadian journal of surgery. Journal canadien de chirurgie, 61(1) (1), E1, 英語, 国際誌Intraoperative ultrasonic cholangiography for biliary system identification.
- 日本臨床外科学会, 2017年06月, 日本臨床外科学会雑誌, 78(6) (6), 1326 - 1331, 日本語
- BACKGROUND: Operative clips used to ligate vessels in abdominal operation usually are made of titanium. They remain in the body permanently and form metallic artifacts in computed tomography images, which impair accurate diagnosis. Although biodegradable magnesium instruments have been developed in other fields, the physical properties necessary for operative clips differ from those of other instruments. We developed a biodegradable magnesium-zinc-calcium alloy clip with good biologic compatibility and enough clamping capability as an operative clip. In this study, we verified the safety and tolerability of this clip for use in canine cholecystectomy. METHODS: Nine female beagles were used. We performed cholecystectomy and ligated the cystic duct by magnesium alloy or titanium clips. The chronologic change of clips and artifact formation were compared at 1, 4, 12, 18, and 24 weeks postoperative by computed tomography. The animals were killed at the end of the observation period, and the clips were removed to evaluate their biodegradability. We also evaluated their effect on the living body by blood biochemistry data. RESULTS: The magnesium alloy clip formed much fewer artifacts than the titanium clip, and it was almost absorbed at 6 months postoperative. There were no postoperative complications and no elevation of constituent elements such as magnesium, calcium, and zinc during the observation period in both groups. CONCLUSION: The novel magnesium alloy clip demonstrated sufficient sealing capability for the cystic duct and proper biodegradability in canine models. The magnesium alloy clip revealed much fewer metallic artifacts in CT than the conventional titanium clip.2017年06月, Surgery, 161(6) (6), 1553 - 1560, 英語, 国際誌研究論文（学術雑誌）
- 2016年10月, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 22(10) (10), 1437 - 42, 英語, 国際誌
- 2016年05月, Journal of the American College of Surgeons, 222(5) (5), e31-8, 英語, 国際誌研究論文（学術雑誌）
- UNLABELLED: To develop a biodegradable clip, the equivalent plastic strain distribution during occlusion was evaluated by the finite element analysis (FEA) using the material data of pure Mg. Since the FEA suggested that a maximum plastic strain of 0.40 is required to allow the Mg clips, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed here by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Small gas cavity due to degradation was observed following implantation of the developed Mg-Zn-Ca clip by in vivo micro-CT. Histological analysis, minimal observed inflammation, and an only small decrease in the volume of the implanted Mg-Zn-Ca clip confirmed its excellent biocompatibility. FEA using the material data for ductile Mg-Zn-Ca also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy. These results suggest that the developed Mg-Zn-Ca alloy is a suitable material for biodegradable clips. STATEMENT OF SIGNIFICANCE: Since conventional magnesium alloys have not exhibited significant ductility for applying the occlusion of vessels, the alloying of magnesium with essential elements and the control of microstructure by hot extrusion and annealing were conducted. Mechanical characterization revealed that the Mg-Zn-Ca alloy obtained by double extrusion followed by annealing at 673K for 2h possessed a fracture strain over 0.40. The biocompatibility of the alloy was confirmed by investigating its degradation behavior and the response of extraperitoneal tissue around the Mg-Zn-Ca alloy. Finite element analysis using the material data for the ductile Mg-Zn-Ca alloy also showed that the clip could occlude the simulated vessel without fracture. In addition, the Mg-Zn-Ca alloy clip successfully occluded the renal vein. Microstructural observations using electron backscattering diffraction confirmed that dynamic recovery occurred during the later stage of plastic deformation of the ductile Mg-Zn-Ca alloy.2016年01月, Acta biomaterialia, 29, 468 - 476, 英語, 国際誌研究論文（学術雑誌）
- [Successful Multimodal Treatment for Aggressive Extrahepatic Metastatic Hepatocellular Carcinoma - A Case Report].A 38-year-old man underwent right hepatectomy for a huge hepatocellular carcinoma(HCC)in the right hepatic lobe. Four months later, recurrent and metastatic disease were observed in the remnant liver and right lung, respectively. We performed a hepatectomy for the recurrent lesion because transcatheter arterial chemoembolization (TACE) was not effective. After surgery, we initiated sorafenib treatment for the lung metastases. One year later, the lung metastases worsened and metastases were observed in the mediastinal lymph nodes, and both metastatic lesions were resected. Seven months later, para-aortic lymph nodal metastasis was observed and dissected. Three months later, metastasis to the supraclavicular lymph node was observed. We performed particle radiation therapy and a complete response was achieved. One year later, metastases in both lungs were observed and resected. Despite continued sorafenib administration throughout the clinical course, a metastasis to the left adrenal gland was observed. This lesion was extirpated because no other recurrent lesions were detected. At 4 years and 6 months after the first operation, no other recurrences have occurred. Currently, sorafenib is the initial drug of choice for HCC with extrahepatic metastases. It is possible to improve the prognosis of patients with HCC and extrahepatic metastases by applying surgical treatment during the course of sorafenib administration.2015年09月, Gan to kagaku ryoho. Cancer & chemotherapy, 42(9) (9), 1111 - 4, 日本語, 国内誌研究論文（学術雑誌）
- Identification and characterization of TMEM33 as a reticulon-binding protein.Endoplasmic reticulum (ER) is an organelle that has an elaborate and continuous membrane system composed of sheet-like cisternae and a network of interconnected tubules. The ER tubules are shaped by reticulons, a conserved ER membrane protein family. However, how the membrane-shaping activity is regulated remains to be elucidated. To understand the mode of action of reticulons, we isolated TMEM33, a conserved protein harboring three transmembrane domains, as a reticulon 4C-binding protein by affinity chromatography. In addition to reticulon 4C, TMEM33 binds to reticulon 1A, -2B, -3C and a reticulon homology domain-containing protein Arl6IP1. Exogenously expressed TMEM33 localizes at both the ER membrane and the nuclear envelope. Exogenously expressed TMEM33 co-localizes with exogenously expressed reticulon 4C well at the ER sheets and partially at the ER tubules. Exogenously expressed TMEM33 suppresses the exogenously expressed reticulon 4C-induced tubulation of ER. These results suggest that TMEM33 has a potency to suppress the membrane-shaping activity of reticulons, thereby regulating the tubular structure of ER.2014年11月, The Kobe journal of medical sciences, 60(3) (3), E57-65, 英語, 国内誌研究論文（学術雑誌）
- [A case of resection of a metastatic liver tumor that recurred after particle beam therapy].Recently, the indications for particle beam therapy have been expanded to include metastatic liver tumors. However, its adverse effects on the treated liver are unclear, and the possibility of local recurrence after treatment should not be ignored. A 65-year-old man with advanced rectal carcinoma underwent low anterior resection. Resectable metastatic liver tumors were detected after adjuvant chemotherapy; however, he opted to undergo particle beam therapy. Nine months after treatment, a local recurrence was detected around the treated area, and central bisegmentectomy of the liver was performed as a salvage operation. The operation was technically complicated owing to severe adhesions and inflammatory changes in the liver parenchyma around the treated area. Pathological examination revealed advanced liver fibrosis at the treated area, in contrast with normal parenchyma in the untreated area. Although the procedure requires advanced surgical techniques, salvage surgery is a feasible option for recurrent liver tumors after particle beam therapy.2014年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2071 - 3, 日本語, 国内誌研究論文（学術雑誌）
- [Long-term survival in a patient receiving multidisciplinary therapy for hepatocellular carcinoma with left iliac bone metastasis].The patient was a 79-year-old man diagnosed with a single 9.3-cm hepatocellular carcinoma (HCC) in the medial segment of the liver, and left iliac bone metastasis. Initially, the patient was treated with a hepatic arterial infusion of low-dose FP (cisplatin/5-fluorouracil) at another hospital. Here, the patient received particle therapy for the left iliac bone metastasis at a total dose of 52.8 Gy in 4 fractions. Subsequently, he underwent medial segmentectomy of the liver to treat the primary HCC. Eleven months later, the first intrahepatic recurrence occurred, and the tumor was treated with percutaneous radiofrequency ablation (RFA). A second intrahepatic recurrence was detected 39 months later, which was also treated with percutaneous RFA. The patient remains well, with no evidence of tumor recurrence.2014年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 41(12) (12), 2107 - 9, 日本語, 国内誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2014年11月, 癌と化学療法, 41(12) (12), 2071 - 2073, 日本語
- (株)癌と化学療法社, 2014年11月, 癌と化学療法, 41(12) (12), 2107 - 2109, 日本語
- 2014年02月, Journal of the American College of Surgeons, 218(2) (2), e43-50, 英語, 国際誌研究論文（学術雑誌）
- (株)南江堂, 2013年12月, 外科, 75(13) (13), 1503 - 1506, 日本語
- [Analysis of the safety and efficacy of percutaneous isolated hepatic perfusion after particle therapy for advanced hepatocellular carcinoma].Here, we report the efficacy of dual treatment with hepatic resection and percutaneous isolated hepatic perfusion (PIHP) for advanced hepatocellular carcinoma( HCC). Recently, we introduced treatment with combined particle therapy and PIHP for unresectable HCC in cases of insufficient liver function. The purpose of this study was to evaluate the safety and efficacy of PIHP for local control in the liver after particle therapy. From 2006 to 2013, 6 patients underwent particle therapy for the main lesion and subsequent PIHP for remnant liver lesions. Their mean age was 64 years, and the mean size of the main lesion was 6.2 cm (range, 2.0-10.8 cm). All patients had liver cirrhosis. After particle therapy, PIHP was performed by hepatic arterial infusion of 100 mg/m2 of doxorubicin and 30 mg/m2 of mitomycin C. With regard to side effects, neutropenia occurred in all patients but no serious hepatobiliary injury was observed. The response rate for PIHP was 50% (partial response: 3 and stable disease: 3). The mean overall survival time was 26.9 months after particle therapy. In conclusion, even after particle therapy, PIHP is a safe treatment and is associated with a good local control rate for remnant HCCs. Further accumulation of data is needed to evaluate the efficacy of this treatment strategy in terms of prognosis.2013年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 40(12) (12), 1681 - 3, 日本語, 国内誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2013年11月, 癌と化学療法, 40(12) (12), 1681 - 1683, 日本語
- (株)医学書院, 2013年04月, 臨床皮膚科, 67(4) (4), 362 - 366, 日本語
- [A case of bilobar multiple hepatocellular carcinoma in which complete remission was achieved by preoperative percutaneous isolated hepatic perfusion and subsequent hepatectomy].We report a case of bilobar multiple hepatocellular carcinoma (HCC) successfully treated by preoperative percutaneous isolated hepatic perfusion(PIHP) and subsequent hepatectomy. A 77-year-old man with elevated serum PIVKA-II level and hepatomas was referred to our hospital. Abdominal dynamic computed tomography and gadoxetate disodium-enhanced magnetic resonance imaging demonstrated advanced HCCs: 11 tumors with a maximum tumor size of 4.8 cm diameter in the right lobe, and 1 tumor of 3.6 cm diameter in the left lobe. Curative resection was impossible due to insufficient liver function and due to the locations of the tumors. Therefore, we performed preoperative PIHP in order to control the multiple HCCs in the right lobe. This resulted in normalization of serum PIVKA-II level and complete necrosis of all tumors in the right lobe, as observed on dynamic computed tomography after 4 weeks of PIHP. Then, at 7 weeks after PIHP, we performed extended left lobectomy for residual tumor in the left lobe. Finally, complete remission was thought to have been achieved. The patient is alive 6 months after PIHP, without recurrence.2012年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 39(12) (12), 1825 - 7, 日本語, 国内誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2012年11月, 癌と化学療法, 39(12) (12), 1825 - 1827, 日本語
- 2012年10月, HEPATOLOGY, 56, 518A - 519A, 英語Long-Term Outcomes and Prognostic Factors with Reductive Hepatectomy and Sequential Percutaneous Isolated Hepatic Perfusion for Multiple Bilobar Hepatocellular Carcinoma
- (株)協和企画, 2012年10月, 漢方医学, 36(4) (4), 303 - 307, 日本語
- (株)医学書院, 2012年09月, 臨床外科, 67(9) (9), 1192 - 1196, 日本語
- Eosinophilic gastroenteritis (EG) is an inflammation of the digestive tract that is characterized by eosinophilic infiltration. There are no specific symptoms, and are related to the layer in which eosinophilic infiltration is observed. A 69-year-old Japanese man presented to our hospital with a history of general malaise, diarrhea, and dysgeusia. Esophagogastroduodenoscopy showed reddish elevated lesions that were edematous all over the gastric mucosa. In addition, three tumors were also observed. The biopsies of the reddish elevated mucosa revealed eosinophilic infiltration and tubular adenocarcinoma from the tumors. Colonoscopy showed abnormal reddish elevated mucosa. The biopsies from the reddish elevated mucosa showed eosinophilic infiltration. From the abdominal contrast computed tomography scan, tumor stain was seen in the anterior wall of the gastric body. No ascites, intestinal wall thickening, or lymph node swelling were found. A slight elevation in the serum immunoglobulin E (IgE), 480 IU/ml, was found from the laboratory test results; other laboratory results were within normal limits including the number of peripheral eosinophils. No specific allergen was found from the multiple antigen simultaneous test and from the skin patch test. The parasitic immunodiagnosis was negative. He was diagnosed with EG associated with gastric cancer and underwent total gastrectomy, regional lymph node dissection with reconstruction by a Roux-en-Y method. He was prescribed prednisolone after the operation and showed a good clinical response. There are many case reports on EG, but none of them were associated with cancer. We encountered a case of EG associated with multiple gastric cancer; the patient underwent total gastrectomy.2012年06月, European journal of gastroenterology & hepatology, 24(6) (6), 727 - 30, 英語, 国際誌研究論文（学術雑誌）
- (株)南江堂, 2011年12月, 外科, 73(13) (13), 1503 - 1507, 日本語
- [A case report of intrahepatic cholangiocarcinoma diagnosed as lung cancer with liver metastasis treated with radiofrequency ablation].In December 2008, a 43-year-old male who had been pointed out a nodular shadow in the right upper field on a chest radiography was admitted to hospital. A 35 mm mass infiltrating to superior vena cava in the right upper lobe of the lung, and 32 mm mass in the liver at S7 were detected by CT. Pathological diagnosis of the liver tumor was adenocarcinoma. Under the diagnosis of lung carcinoma and liver metastasis, systemic chemotherapy was started from January 2009. Radiofrequency ablation (RFA) therapy was added for liver S7 mass in February, and radiation therapy was performed for lung mass in December. The lung lesion has markedly reduced, but the liver lesion recurred in October 2009, which continued to grow up to 80 mm until August 2010. He presented to our hospital with the diagnosis of liver metastasis of controlled primary lung cancer. In October, we performed right hepatectomy with diaphragma and right lung resection. The pathological diagnosis was intrahepatic cholangiocarcinoma. Multiple recurrences in remnant liver, lung and peritoneal metastasis were detected in January 2011. For intrahepatic cholangiocarcinoma, hepatectomy is the only established treatment, and RFA treatment remains controversial. Clinical diagnosis of multiple cancers should be decided with caution.2011年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 38(12) (12), 2030 - 2, 日本語, 国内誌研究論文（学術雑誌）
- [A case report of multiple advanced hepatocellular carcinomas treated by combination therapy with hepatectomy and particle therapy].We report a case of multiple advanced hepatocellular carcinomas (HCC) with bilobar distribution treated by combination therapy of hepatectomy and particle therapy (carbon ion therapy). A 73-year-old man who had been pointed out hepatic tumors on abdominal CT was referred to our hospital in February 2010. Advanced HCCs; 8 cm Vp3 and 6 cm in the left lobe, 4 cm in the posterior segment, and 1 .5 cm in the S8 area, were detected by abdominal dynamic CT and EOB-MRI etc. Curative resection was not applied due to insufficiency of liver function and unfavorable anatomical tumor locations. Accordingly we have developed a novel combination therapy of hepatectomy and particle therapy. First we performed left lobectomy in March 2010, followed by administration of particle therapy to the posterior segment for local control in May. Then, transcatheter arterial chemoembolization was administered 4 times for residual tumors. The patient survives for 15 months after the initial therapy with good local control.2011年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 38(12) (12), 2065 - 7, 日本語, 国内誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2011年11月, 癌と化学療法, 38(12) (12), 2030 - 2032, 日本語
- (株)癌と化学療法社, 2011年11月, 癌と化学療法, 38(12) (12), 2065 - 2067, 日本語
- 2011年10月, HEPATOLOGY, 54, 681A - 681A, 英語RENAL FUNCTION DETERIORATES AFTER LIVING DONOR LIVER TRANSPLANTATION; HOW TO PREDICT CHRONIC DYSFUNCTION?
- 2011年10月, HEPATOLOGY, 54, 1385A - 1386A, 英語PERCUTANEOUS ISOLATED HEPATIC PERFUSION (PIHP) FOR ADVANCED HEPATOCELLULAR CARCINOMA: TWO DECADES EXPERIENCE OF KOBE PROGRAM
- 日本皮膚科学会-大阪地方会・京滋地方会, 2011年04月, 皮膚の科学, 10(2) (2), 189 - 189, 日本語上腕に紫紅色結節を呈した転移性皮膚腫瘍の1例
- We report the intact surviving case of a newborn with a birth weight of 412 g delivered from an active systemic lupus erythematosus (SLE) mother with antiphospholipid syndrome. A review of the literature revealed that our infant is the lowest surviving birth weight in newborns from SLE mothers to date.2010年09月, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 23(9) (9), 1050 - 2, 英語, 国際誌研究論文（学術雑誌）
- APA/JPS/CAP/IAP 2024, 2024年12月, 英語, 国際会議Comprehensive analysis of altered lipid and amino acid metabolism in patients undergoing pancreatoduodenectomy口頭発表（一般）
- 第41回近畿肝移植検討会, 2024年12月, 日本語, 国内会議家族性βリポ蛋白血症による非代償性硬変に対し脳死肝移植を行った一例口頭発表（一般）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議胆嚢摘出既往のある再肝切除症例における腹腔鏡アプローチの有用性に関する検討口頭発表（一般）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議糖原病Ia型に併発した多発肝細胞癌線腫の1切除例口頭発表（一般）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議Fontan循環における腹腔鏡下肝切除術の経験口頭発表（一般）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議3Dシミュレーション画像は真のリアルタイムナビゲーションになっているか？シンポジウム・ワークショップパネル（公募）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議膵癌に対する腹腔鏡下膵体尾部切除術の短期・長期成績に関する検討シンポジウム・ワークショップパネル（公募）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議40歳肝胆膵外科医の腹腔鏡下膵切除の実際シンポジウム・ワークショップパネル（公募）
- 第37回日本内視鏡外科学会総会（JSES2024）, 2024年12月, 日本語, 国内会議ロボット支援下膵切除導入の経験とフィードバックシンポジウム・ワークショップパネル（公募）
- 第86回日本臨床外科学会総会, 2024年11月, 日本語, 国内会議進行肝細胞癌に対するアテゾリズマブ・ベバシズマブ併用療法によるcancer free/drug freeを目指した治療戦略シンポジウム・ワークショップパネル（公募）
- 第86回日本臨床外科学会総会, 2024年11月, 日本語, 国内会議腹腔鏡下肝切除技術認定取得への道シンポジウム・ワークショップパネル（公募）
- 第18回肝臓内視鏡外科研究会, 2024年11月, 日本語, 国内会議Clamp crushing法を駆使した腹腔鏡下肝切除シンポジウム・ワークショップパネル（公募）
- 第66回日本消化器病学会大会（JDDW2024）, 2024年10月, 日本語, 国内会議Postoperative complications assessed by the comprehensive complication index (CCI) are associated with early recurrence after curative resection for biliary tract cancerポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議Clinical Significance of Laparoscopic 0-mm Margin Liver Resection for Vascular in Patients with Hepatocellular Carcinomaポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議吸収性スペーサー併用粒子線治療後に局所再発した後腹膜平滑筋肉腫に対して2回目の吸収性スペーサー留置術および粒子線治療を行った1例ポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議左側門脈圧亢進症に対する門脈ステントの有用性についてポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議胆道癌術後S-1術後補助療法施行例におけるGLIM基準の予後因子としての有用性に関する検討ポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議胆道癌に対するS-1術後補助化学療法と術後早期再発との関連ポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議膵頭十二指腸切除術後の血中必須脂肪酸の推移およびPD後NAFLDとの関係ポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議進行肝細胞癌に対する薬物療法を中心とした集学的治療ポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議膵癌術後再発病変に対する外科的切除は予後延長に寄与するのかポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議主要脈管近接腫瘍に対する腹腔鏡下Parenchymal-sparing hepatectomyポスター発表
- 第22回日本消化器外科学会（JDDW2024）, 2024年10月, 日本語, 国内会議肝細胞癌症例における肝切除術後胆汁漏の予後への影響についての検討ポスター発表
- 第58回近畿肝癌談話会, 2024年10月, 日本語, 国内会議腫瘍学的切除可能性分類定義に基づいた肝切除・薬物療法成績の検討口頭発表（一般）
- ILLS2024, 2024年10月, 英語, 国際会議Laparoscopic anatomic liver resection of segment 7 guided by 3D simulation and ICG fluorescence imagingシンポジウム・ワークショップパネル（公募）
- 第60回日本移植学会総会, 2024年09月, 日本語, 国内会議家族性低βリポ蛋白血症に伴う非代償性肝硬変に対して脳死肝移植術を施行した1例ポスター発表
- 第60回日本移植学会総会, 2024年09月, 日本語, 国内会議肝移植後 MASLD 発症を予測する因子に関する観察研究ポスター発表
- 第60回日本移植学会総会, 2024年09月, 日本語, 国内会議当院における high MELD score 肝不全に対する肝移植の治療成績シンポジウム・ワークショップパネル（公募）
- 第47回日本膵・胆管合流異常研究会, 2024年09月, 日本語, 国内会議膵・胆管合流異常に合併した2型 IPNB に相当する胆嚢内乳頭状腫瘍の1例口頭発表（一般）
- ELSA2024, 2024年08月, 英語, 国際会議Optimal cutoff values of drain amylase for predicting pancreatic fistula are different between open and laparoscopic distal pancreatectomy口頭発表（一般）
- ELSA2024, 2024年08月, 英語, 国際会議The first-touch skills in robotic surgical training using a new Japanese surgical robot system and its simulatorシンポジウム・ワークショップパネル（公募）
- 第30回日本肝がん分子標的治療研究会, 2024年07月, 日本語, 国内会議デュルバルマブ・トレメリムマブ併用療法導入初期の治療成績から薬物療法の最適な se-quence を考える口頭発表（一般）
- 第55回日本膵臓学会大会, 2024年07月, 日本語, 国内会議局所進行切除不能膵癌に対するスペーサー留置術後の陽子線治療の成績と展望口頭発表（一般）
- 第55回日本膵臓学会大会, 2024年07月, 日本語, 国内会議膵癌に対する膵切除術における膵断端の癌遺残に関する検討シンポジウム・ワークショップパネル（公募）
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), 2024年07月, 日本語, 国際会議Textbook outcomes in initial liver resection for hepatocellular carcinoma: a study with malnutrition grade by the GLIM criteria.ポスター発表
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), 2024年07月, 日本語, 国際会議Clinical significance of hepatectomy for Hepatocellular Carcinoma Associated with Lymph Node and/or Distant Metastasesポスター発表
- The 14th Asia-Pacific Primary Liver Cancer Expert Meeting 2024 (APPLE), 2024年07月, 日本語, 国際会議Laparoscopic Liver Resection after Pancreaticoduodenectomyポスター発表
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議当科における吸収性スペーサー留置術 48 例の検討口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議GLIM 基準でみる肝細胞癌に対する肝切除の Textbook outcome口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議肝細胞癌における腹腔鏡下 SM0 肝切除の有用性に関する検討口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議切除後再発リスク分類と大腸癌肝転移の集学的治療戦略口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議インドシアニングリーンを用いた蛍光ガーゼの新規開発口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議肝細胞癌に対する幕内基準外肝右葉切除後における術後肝不全発症の危険因子の検討口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議術後難治性胆管狭窄症例に対する治療経験口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議当科における進行胆道癌に対する conversion surgery の経験口頭発表（一般）
- 第79回日本消化器外科学会総会, 2024年07月, 日本語, 国内会議胆嚢摘出術既往のある再肝切除症例における開腹，腹腔鏡アプローチの手術成績の比較口頭発表（一般）
- 第60回日本肝癌研究会, 2024年07月, 日本語, 国内会議進行肝細胞癌に対するアテゾリズマブ・ベバシズマブ療法による cancer free、 drug free を目指した治療戦略口頭発表（一般）
- 第60回日本肝癌研究会, 2024年07月, 日本語, 国内会議肝細胞癌における肝切除術後胆汁漏関連因子の予後への影響に関する検討口頭発表（一般）
- 第60回日本肝癌研究会, 2024年07月, 日本語, 国内会議当科における全腫瘍体積を用いた大腸癌肝転移の治療戦略シンポジウム・ワークショップパネル（公募）
- 第60回日本肝癌研究会, 2024年07月, 日本語, 国内会議腫瘍学的切除可能性分類定義に基づいた肝切除・薬物療法成績の検討シンポジウム・ワークショップパネル（公募）
- 第36回日本肝胆膵外科学会・学術集会, 2024年06月, 日本語, 国内会議Comparison of laparoscopic partial liver resection for the superior and the inferior areas of segment 4口頭発表（一般）
- 第36回日本肝胆膵外科学会・学術集会, 2024年06月, 日本語, 国内会議Efficacy of the bile leak test using contrast-enhanced intraoperative ultrasonic cholangiography in liver resection: A prospective study口頭発表（一般）
- 第36回日本肝胆膵外科学会・学術集会, 2024年06月, 日本語, 国内会議A Novel Navigation Technology for Liver Surgery Using Spectral Imaging口頭発表（一般）
- 第36回日本肝胆膵外科学会・学術集会, 2024年06月, 日本語, 国内会議Clinical significance of hepatectomy for hepatocellular carcinoma associated with lymph node and/ or distant metastasesシンポジウム・ワークショップパネル（公募）
- 第36回日本肝胆膵外科学会・学術集会, 2024年06月, 日本語, 国内会議Treatment outcomes of hepatectomy and systemic chemotherapy based on the oncological criteria of resectabilityシンポジウム・ワークショップパネル（公募）
- 第46回日本癌局所療法研究会, 2024年06月, 日本語, 国内会議腹腔鏡下膵頭十二指腸切除術で R0 手術となった胆管原発神経内分泌癌の1切除例口頭発表（一般）
- Computer Assisted Radiology and Surgery 38th International Congress and Exhibition(CARS2024 ), 2024年06月, 英語, 国際会議Surgical Robot Logs and Their Potential Towards Autonomous and Skill Transfer口頭発表（一般）
- 第60回日本肝臓学会総会, 2024年06月, 日本語, 国内会議デュルバルマブ・トレメリムマブ併用療法導入初期の治療成績口頭発表（一般）
- 第60回日本肝臓学会総会, 2024年06月, 日本語, 国内会議切除不能肝細胞癌に対するアテゾリズマブ/ベバシズマブ併用療法の治療効果と全腫瘍体積の関連性についての検討口頭発表（一般）
- 第60回日本肝臓学会総会, 2024年06月, 日本語, 国内会議肝切除後患者に対するアテゾリズマブ・ベバシズマブ併用療法の治療効果と安全性口頭発表（一般）
- 第60回日本肝臓学会総会, 2024年06月, 日本語, 国内会議腫瘍学的切除可能性分類定義に基づいた肝切除・薬物療法成績の検討口頭発表（一般）
- EAES2024, 2024年06月, 英語, 国内会議Laparoscopic SM0 liver resection for hepatocellular carcinoma adjacent to the hepatic hilumポスター発表
- 第42回日本肝移植学会学術集会, 2024年06月, 日本語, 国内会議当施設の脳死ドナー肝摘出手技習得における Cadaver Surgical Training の有用性シンポジウム・ワークショップパネル（公募）
- 第42回日本肝移植学会学術集会, 2024年06月, 日本語, 国内会議肝移植後の MASLD 発症を予測する因子に関する検討口頭発表（一般）
- 第42回日本肝移植学会学術集会, 2024年06月, 日本語, 国内会議当院の脳死肝移植における Japan Risk Index の検討口頭発表（一般）
- 日本蛍光ガイド手術研究会第7回学術集会, 2024年05月, 日本語, 国内会議ICGを用いた蛍光ガーゼの新規開発口頭発表（一般）
- 第110回日本消化器病学会総会, 2024年05月, 日本語, 国内会議大腸癌肝転移におけるRAS遺伝子情報と肝転移巣局在の関連性口頭発表（一般）
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議当科における吸収性スペーサー留置術 45 例の検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議胆道癌術後 S-1 術後補助療法施行例における GLIM 基準の予後因子としての有用性に関する検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議当院における肝 S8 背側/腹側領域に対する腹腔鏡下肝部分切除術の手術成績ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議胆道癌における再発時期と再発様式についての検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議進行肝細胞癌における腫瘍肉眼形態とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議肝切除における術中超音波胆道造影法を併用したリークテストの有用性ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議外科医が長く働き続けられるための当院での取り組みポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議肝門部胆管癌における術後肝不全・難治性腹水ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議大腸癌肝転移における切除後再発リスク分類と集学的治療戦略ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議肝細胞癌に対する肝右葉切除後における術後肝不全発症の危険因子の検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議肥満症例での肝 S7 切除における腹腔鏡下アプローチのメリットについてポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議高齢遠位胆管癌患者に対する高難度手術成績の検討ポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議進行胆道癌に対する Conversion surgeryポスター発表
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議胆道癌に対する膵頭十二指腸切除術における GLIM 基準低栄養が術後合併症へ与える影響の検討口頭発表（一般）
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議膵頭十二指腸切除術後外分泌不全に対する治療バイオマーカーの探索口頭発表（一般）
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議開腹および腹腔鏡下膵体尾部切除のドレーンアミラーゼ値による適切なドレーン管理の検討口頭発表（一般）
- 第124回日本外科学会定期学術集会, 2024年04月, 日本語, 国内会議肝細胞癌薬物療法における sequential 局所治療の位置づけシンポジウム・ワークショップパネル（公募）
- SAGES 2024, 2024年04月, 英語, 国際会議Robot log and its potential for autonomous robotic surgery and skill transferポスター発表
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), 2024年03月, 英語, 国際会議Utility of ALBI grade for predicting prognoses in patients who underwent repeat hepatectomyポスター発表
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), 2024年03月, 英語, 国際会議Multidisciplinary treatment strategy for macroscopic portal vein tumor thrombusポスター発表
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), 2024年03月, 英語, 国際会議Association between tumor morphology and efficacy of atezolizumab plus bevacizumab for advanced HCC口頭発表（一般）
- The 33rd Annual Meeting the Asian Pacific Association for the Study of the Liver (APASL2024), 2024年03月, 英語, 国際会議A comparative study of laparoscopic liver resection for the segment 4 superior and inferior area口頭発表（一般）
- 第51回近畿肝臓外科研究会, 2024年02月, 日本語, 国内会議主要脈管近接腫瘍に対する腹腔鏡下肝切除口頭発表（一般）
- 第20回関西肝臓外科医育成の会, 2024年02月, 日本語, 国内会議取得者から学ぶHow to get 高度技能医・技術認定医口頭発表（一般）
- 第56回制癌剤適応研究会, 2024年02月, 日本語, 国内会議GC+ デュルバルマブ療法が奏功し根治的肝切除術を施行し得た胆嚢癌術後肝転移再発の 1 例口頭発表（一般）
- 日本消化器病学会近畿支部第120回例会, 2024年01月, 日本語, 国内会議胆道再建既往の肝切除症例における術後感染性合併症口頭発表（一般）
- 日本消化器病学会近畿支部第120回例会, 2024年01月, 日本語, 国内会議GLIM基準低栄養は胆道癌に対する膵頭十二指腸切除術後合併症リスクを増加させる口頭発表（一般）
- 第40回近畿肝移植検討会, 2023年12月, 日本語, 国内会議「当院におけるアルコール性肝硬変に対する肝移植後再飲酒要因の検討」口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議師匠の背中を見て育つをデジタル化するシンポジウム・ワークショップパネル（公募）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議腹腔鏡下肝 S8 部分切除術における背側領域と腹側領域での手術成績比較口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議肝細胞癌に対する腹腔鏡下 SM0 resection の短期成績口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議手術支援ロボットのトレーニングにおける First touch でのロボット操作への順応性の評価口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議肝門部に近接する肝細胞癌に対する腹腔鏡下肝部分切除術口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議当科における肝 S1 病変に対する腹腔鏡手術の有効性と安全性の検討口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議肝臓外科におけるロボット支援化手術導入への悩み口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議ロボット支援下手術の拡大視野で得られた門脈輪状膵症例におけるSMA神経叢に関する知見シンポジウム・ワークショップパネル（公募）
- 第36回日本内視鏡外科学会総会, 2023年12月, 日本語, 国内会議司会（ミニオーラル205）その他
- 第45回日本肝臓学会西部会, 2023年12月, 日本語, 国内会議肝細胞癌再発に対してラムシルマブ長期投与が可能であった1例口頭発表（一般）
- 第45回日本肝臓学会西部会, 2023年12月, 日本語, 国内会議肝予備能不良な肝細胞癌に対して吸収性スペーサー留置後に陽子線治療を施行し腫瘍制御が得られた1例口頭発表（一般）
- 第17回肝臓内視鏡外科研究会, 2023年11月, 日本語, 国内会議腹腔鏡下肝 S8 部分切除術の手術手技の肝（キモ）～ S8 腹側・背側領域の比較を含めて～シンポジウム・ワークショップパネル（公募）
- 第85回日本臨床外科学会総会, 2023年11月, 日本語, 国内会議アテゾリズマブ＋ベバシズマブ併用療法によりコンバージョン手術を施行し得た切除不能肝 細胞癌の2例ポスター発表
- 第85回日本臨床外科学会総会, 2023年11月, 日本語, 国内会議吸収性スペーサー留置術35例の検討ポスター発表
- 第85回日本臨床外科学会総会, 2023年11月, 日本語, 国内会議肝細胞癌薬物療法を外科医が行う意義口頭発表（一般）
- 第85回日本臨床外科学会総会, 2023年11月, 日本語, 国内会議肝細胞癌薬物療法後コンバージョン治療の可能性シンポジウム・ワークショップパネル（公募）
- 第65回日本消化器病学会大会（JDDW2023), 2023年11月, 日本語, 国内会議胆道癌における再発時期と再発形式の検討ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議肝外胆管癌における術前骨格筋量減少の術後早期再発への影響ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議The feasibility of laparoscopic liver resection with 0-mm surgical margin for hepatocellular carcinomaポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議吸収性スペーサー留置術33例の検討ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議肝門部胆管癌術後の術後胆汁漏の検討ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議肝切除術後の門脈血栓症に対するエドキサバンの治療成績ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議胆管非拡張型膵・胆管合流異常に対する胆嚢摘出後に胆管径は変化するかポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議膵癌術後再発に対する治療戦略の現状と展望ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議ハイパースペクトルイメージングを用いた新たな肝臓手術ナビゲーション技術の開発ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議初回肝切除への腹腔鏡アプローチ適応による再肝切除時のメリットについてポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議当院における術後胆管狭窄症例に対する対応と検討ポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議根治を目指した肝細胞癌薬物療法と局所療法のコンビネーションポスター発表
- 第21回日本消化器外科学会大会（JDDW2023）, 2023年11月, 日本語, 国内会議肝外胆管癌切除後S-1補助化学療法例におけるGLIM基準の有用性に関する検討ポスター発表
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, 2023年11月, 英語, 国際会議Association between tumor morphology and efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinomaポスター発表
- 7th Kansai-Yeungnam HBP Surgeons Meeting, 2023年10月, 英語, 国際会議Risk Factors for Recurrence of Cholangitis After Pancreaticoduodenectomy and Comparison of Stents in Hepaticojejunostomyポスター発表
- 第59回日本移植学会総会, 2023年09月, 日本語, 国内会議肝移植後の経時的な体重変化を予測する因子についての観察研究ポスター発表
- 第59回日本移植学会総会, 2023年09月, 日本語, 国内会議脳死肝移植・肝グラフト採取術手技習得における Cadaver Surgical Training の有用性口頭発表（一般）
- 第59回日本移植学会総会, 2023年09月, 日本語, 国内会議次世代継承、肝移植のススメ口頭発表（一般）
- 第59回日本移植学会総会, 2023年09月, 日本語, 国内会議当施設における RTC 育成の現状と課題シンポジウム・ワークショップパネル（公募）
- 第59回日本胆道学会学術集会, 2023年09月, 日本語, 国内会議胆道癌術後補助化学療法施行例における早期再発のリスク因子の検討ポスター発表
- 第59回日本胆道学会学術集会, 2023年09月, 日本語, 国内会議当科で経験した無石性胆嚢炎症例の臨床像ポスター発表
- 第59回日本胆道学会学術集会, 2023年09月, 日本語, 国内会議胆道癌に対するS-1術後補助化学療法と再発時期の関連ポスター発表
- 4th World Congress of International Laparoscopic liver Society（ILLS2023）, 2023年09月, 英語, 国際会議A comparative study of laparo-scopic liver resection for the segment 8 dorsal and ventral area口頭発表（一般）
- 4th World Congress of International Laparoscopic liver Society（ILLS2023）, 2023年09月, 英語, 国際会議Short-term impact of laparoscopic liver resection with 0-mm surgical margin for HCC口頭発表（一般）
- 4th World Congress of International Laparoscopic liver Society（ILLS2023）, 2023年09月, 英語, 国際会議Acceptability of Laparoscopic Liver Resection of Segment I: A Retrospective Study口頭発表（一般）
- 4th World Congress of International Laparoscopic liver Society（ILLS2023）, 2023年09月, 英語, 国際会議Laparoscopic segmentectomy2 versus left lateral sectionecto-my for liver tumors in segment2口頭発表（一般）
- 45th ESPEN Congress, 2023年09月, 英語, 国際会議Impact of malnutrition diagnosed by the GLIM criteria on postoperative complications after pancreaticoduodenectomy for biliary tract cancerポスター発表
- 45th ESPEN Congress, 2023年09月, 英語, 国際会議Impact of malnutrition diagnosed by the GLIM criteria on outcome of elderly patients with hepatocellular carcinoma after liver resectionポスター発表
- 第46回日本膵・胆管合流異常研究会, 2023年09月, 日本語, 国内会議膵・胆管合流異常に発生した膵管内乳頭粘液性腺癌の1切除例口頭発表（一般）
- 第57回近畿肝癌談話会, 2023年08月, 日本語, 国内会議根治を目指した肝細胞癌薬物療法シークエンス口頭発表（一般）
- 第59回日本肝癌研究会, 2023年07月, 日本語, 国内会議根治を目指した肝細胞癌薬物療法シークエンス口頭発表（一般）
- 第59回日本肝癌研究会, 2023年07月, 日本語, 国内会議肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討シンポジウム・ワークショップパネル（公募）
- 第54回日本膵臓学会大会, 2023年07月, 日本語, 国内会議高齢者に対する膵全摘, 残膵全摘の短期・長期成績についてシンポジウム・ワークショップパネル（公募）
- 第78回日本消化器外科学会総会, 2023年07月, 日本語, 国際会議門脈腫瘍栓を伴う肝細胞癌患者における EOB-MRI を用いた機能的残肝容積測定による術後肝不全予測法口頭発表（一般）
- 第78回日本消化器外科学会総会, 2023年07月, 日本語, 国内会議肝細胞癌肝切除症例における術前サルコペニアが予後に与える影響口頭発表（一般）
- 第78回日本消化器外科学会総会, 2023年07月, 日本語, 国内会議肝細胞癌患者における肝切除後肝不全が中長期的肝機能と再発に与える影響口頭発表（一般）
- 第78回日本消化器外科学会総会, 2023年07月, 日本語, 国内会議内側アプローチによる腹腔鏡下 Spiegel 葉切除口頭発表（一般）
- 第78回日本消化器外科学会総会, 2023年07月, 日本語, 国内会議First touch でのロボット支援手術トレーニングスキルから考える手術教育口頭発表（一般）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議A study for infectious complication of hepatectomies in patients with preexisting bilioenteric anastomosisポスター発表
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Association between morphologic appearance in CT/MRI and efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinomaポスター発表
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Intracholecystic papillary neoplasm (ICPN) with pancreaticobiliary maljunction (PBM): Comparison with normal gallbladder cancer with PBMポスター発表
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Successful biliary drainage using hybrid EUS-BD for stricture of choledochojejunostomyポスター発表
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Intended destination for a board certified surgeon under 45口頭発表（一般）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Prognostic significance of malnutrition diagnosed by the GLIM criteria for resected extrahepatic cholangiocarcinoma: A single-center retrospective study口頭発表（一般）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議The optimal treatment strategy of therapeutic intervention using total tumor volume in patients with colorectal liver metastases口頭発表（一般）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Improvement in stapler pancreatic transection to reduce pancreatic fistula after laparoscopic distal pancreatectomy: twelve-year experience at a single high-volume center口頭発表（一般）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Anterior approach for open right hepatectomy for huge hepatocellular carcinomaシンポジウム・ワークショップパネル（公募）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Our surgical technique of vascular dissection and resection for locally advanced pancreatic cancerシンポジウム・ワークショップパネル（公募）
- 第35回日本肝胆膵外科学会学術集会, 2023年06月, 日本語, 国内会議Legitimacy of systemic chemotherapy for unresectable hepatocellular carcinoma aiming conversion hepatectomyシンポジウム・ワークショップパネル（公募）
- The 31st International Congress of the European Association for Endoscopic Surgery (EAES), 2023年06月, 英語, 国際会議Impact of Sarcopenia as a Prognostic Factor on Laparoscopic or Open Hepatectomy for Hepatocellular Carcinomaポスター発表
- The 31st International Congress of the European Association for Endoscopic Surgery (EAES), 2023年06月, 英語, 国際会議Laparoscopic Liver Resection after Pancreaticoduodenectomyポスター発表
- 第59回日本肝臓学会総会, 2023年06月, 日本語, 国内会議肝細胞癌肉眼分類とアテゾリズマブ・ベバシズマブ併用療法の治療効果に関する検討口頭発表（一般）
- 第59回日本肝臓学会総会, 2023年06月, 日本語, 国内会議切除不能肝内胆管癌に対する粒子線治療の成績口頭発表（一般）
- 第59回日本肝臓学会総会, 2023年06月, 日本語, 国内会議高度脈管侵襲陽性肝細胞癌に対する集学的治療口頭発表（一般）
- 第68回国際外科学会日本部会総会, 2023年06月, 日本語, 国内会議Investigation of the relationship between complications after pancreaticoduodenectomy for distal cholangiocarcinoma and malnutrition diagnosed by the GLIM criteria口頭発表（一般）
- 第45回日本癌局所療法研究会, 2023年06月, 日本語, 国内会議腹腔動脈狭窄を伴う十二指腸乳頭部癌に対し膵頭十二指腸切除術を施行した１例口頭発表（一般）
- 第41回日本肝移植学会学術集会, 2023年06月, 日本語, 国内会議脳死肝移植に初めて参加した経験から得られた移植医療に対する抱負口頭発表（一般）
- 第41回日本肝移植学会学術集会, 2023年06月, 日本語, 国内会議当科における MELD スコア制導入後の脳死肝移植希望登録患者に関する検討シンポジウム・ワークショップパネル（公募）
- 第41回日本肝移植学会学術集会, 2023年06月, 日本語, 国内会議COVID-19により変貌を遂げた急性肝不全に対する移植医療シンポジウム・ワークショップパネル（公募）
- ILTS2023, 2023年05月, 日本語, 国内会議The factors of predicting over-time weight increase after liver transplantationポスター発表
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会Under 40外科医が専門医取得の次に目指すもの
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会正確な局所解剖に基づいた肝細胞癌に対する合理的肝切除術とは 初回再発形式からみる表在性肝細胞癌に対する非系統的切除術の妥当性に関する検討
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会肝移植後長期成績向上のために,何が必要か
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会術前化学療法後に切除を施行したBR-A膵癌,UR-LA膵癌における早期再発risk因子の検討
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会ロボット支援下膵体尾部切除導入期に直面する技術的問題点
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会大腸癌肝転移における予後予測因子としての全腫瘍体積の有用性と,適切な化学療法導入時期に関する観察研究
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会治療成績から見た大腸癌肝転移における切除可能性分類と治療戦略
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会当科における吸収性スペーサー留置術22例の臨床経過
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会肝細胞癌切除症例におけるGLIM基準と予後の関連
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会右肝葉切除を施行した肝門部領域胆管癌の再考 左側からの切除の可能性
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会肝門部領域胆管癌に対する術前門脈塞栓術施行例の検討
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会肝外胆管癌切除後の早期再発予測におけるGLIM基準の有用性
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会肝外胆管癌切除後予後因子としてのGLIM基準の有用性に関する検討
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会十二指腸乳頭部癌におけるC-reactive protein to albumin ratio(CAR)の予後への影響
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会術前NLR値と胆嚢癌の予後との関連
- 日本外科学会定期学術集会抄録集, 2023年04月, 日本語, (一社)日本外科学会胆道癌における術後静脈血栓症と血漿Dダイマーの関連性の検討
- 肝臓, 2023年04月, 日本語, (一社)日本肝臓学会切除不能肝内胆管癌に対する粒子線治療の成績
- 兵庫県外科医会会誌, 2023年03月, 日本語, 兵庫県外科医会横隔膜腹腔側に発生したsolitary fibrous tumorの1例
- 兵庫県外科医会会誌, 2023年03月, 日本語, 兵庫県外科医会横隔膜腹腔側に発生したsolitary fibrous tumorの1例
- 日本消化器病学会雑誌, 2023年03月, 日本語, (一財)日本消化器病学会術前骨格筋量減少が肝外胆管癌切除後の長期予後に与える影響に関する観察研究
- 日本消化器病学会雑誌, 2023年03月, 日本語, (一財)日本消化器病学会食道胃静脈瘤に対するHassab手術が術後肝機能に与える影響についての検討
- 肝臓, 2022年10月, 日本語, (一社)日本肝臓学会初回再発形式からみる肝細胞癌の腫瘍位置と初回再発形式に関する検討
- 日本癌治療学会学術集会抄録集, 2022年10月, 英語, (一社)日本癌治療学会進行肝細胞がんに対する新しい治療戦略と集学的治療の明日 神戸大学における肝癌集学的治療の現状
- 第38回近畿肝移植検討会, 2021年12月, 日本語, 国内会議新型コロナ感染拡大が肝移植にもたらした影響と問題点口頭発表（一般）
- 第44回日本肝臓学会西部会, 2021年12月, 日本語, 国内会議肝移植後合併症に対する移植時年齢の及ぼす影響に関する検討口頭発表（一般）
- 第44回日本肝臓学会西部会, 2021年12月, 日本語, 国内会議高度進行肝細胞癌に対する減量切除症例におけるサルコペニアの影響について口頭発表（一般）
- 第44回日本肝臓学会西部会, 2021年12月, 日本語, 国内会議進行肝細胞癌に対するアテゾリズマブ・ベバシズマブ併用療法の検討口頭発表（一般）
- 第44回日本肝臓学会西部会, 2021年12月, 日本語, 国内会議肝移植患者におけるグラフトへの脂肪肝発症の現状と課題口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 2021年12月, 日本語, 国内会議Glissoneanアプローチを用いた腹腔鏡下肝S2亜区域切除口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 2021年12月, 日本語, 国内会議腹腔鏡下肝S7切除の手術成績の検討口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 2021年12月, 日本語, 国内会議尾状葉切除における手術手技の工夫シンポジウム・ワークショップパネル（公募）
- 第6回神戸肝胆膵外科ビデオクリニック, 2021年11月, 日本語, 国内会議【肝臓】口頭発表（一般）
- 第83回日本臨床外科学会総会, 2021年11月, 日本語, 国内会議肝切除術におけるDemarcation lineとIntersegmental planeナビゲーションシンポジウム・ワークショップパネル（公募）
- 第83回日本臨床外科学会総会, 2021年11月, 日本語, 国内会議コロナ禍において推進すべき肝移植医療の現状と課題シンポジウム・ワークショップパネル（指名）
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議大腸癌肝転移における予後予測因子としての全腫瘍体積の有用性に関する検討ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議腹部悪性腫瘍に対する粒子線治療適応拡大を可能とする新規素材吸収性スペーサーの開発と臨床応用ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議当院でのレンバチニブ治療症例の検討ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議膵癌術前治療が及ぼす骨格筋量変化と手術成績に関する検討ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議膵頭十二指腸切除後に孤立性門脈内再発をきたした膵神経内分泌腫瘍の1例ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議肝臓外科における術中ナビゲーションの現在から未来：術中超音波，ICG蛍光法から血管内超音波，ハイパースペクトルイメージングへシンポジウム・ワークショップパネル（公募）
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議肝細胞癌再発に対する肝切除後の再発リスク因子の検討ポスター発表
- 第19回消化器外科学会大会（JDDW2021）, 2021年11月, 日本語, 国内会議高齢者に対する胆嚢癌手術の検討ポスター発表
- 第57回日本胆道学会学術集会, 2021年10月, 日本語, 国内会議総胆管嚢腫に対する胆管切除術後に発症した胆管癌の１例口頭発表（一般）
- 第57回日本胆道学会学術集会, 2021年10月, 日本語, 国内会議胆道癌におけるSystematic inflammation-based scoresの意義口頭発表（一般）
- 第57回日本移植学会総会, 2021年09月, 日本語, 国内会議膵島移植の成績向上に向けて ー自家膵島移植の検討から見えてきたものー口頭発表（一般）
- 第57回日本移植学会総会, 2021年09月, 日本語, 国内会議移植医療における働き方改革の推進シンポジウム・ワークショップパネル（公募）
- 日本消化器病学会近畿支部第115回例会, 2021年09月, 日本語, 国内会議座長（Young Inverstigator session12)その他
- 第44回日本膵・胆管合流異常研究会, 2021年09月, 日本語, 国内会議総胆管嚢腫に対する嚢腫胆管切除術後の膵内胆管に発癌を認めた1例口頭発表（一般）
- 移植, 2021年09月, 日本語, (一社)日本移植学会膵島移植の成績向上に向けて 自家膵島移植の検討から見えてきたもの
- 胆道, 2021年08月, 日本語, 日本胆道学会総胆管嚢腫に対する胆管切除術後に発症した胆管癌の1例
- 第57回日本肝癌研究会, 2021年07月, 日本語, 国内会議術前検査施行後に自然退縮を来した肝細胞癌5例の手術経験口頭発表（一般）
- 第57回日本肝癌研究会, 2021年07月, 日本語, 国内会議術前サルコペニアと高度進行肝細胞癌に対する減量切除症例との関連について口頭発表（一般）
- 第57回日本肝癌研究会, 2021年07月, 日本語, 国内会議DAA 治療後肝癌に対する肝切除症例の検討口頭発表（一般）
- 第57回日本肝癌研究会, 2021年07月, 日本語, 国内会議肝細胞癌再発に対する腹腔鏡手術適応の予後への影響について口頭発表（一般）
- 第57回日本肝癌研究会, 2021年07月, 日本語, 国内会議高度進行肝細胞癌に対する集学的アプローチ口頭発表（一般）
- 第8回南大阪肝胆膵内視鏡外科研究会, 2021年07月, 日本語, 国内会議session1口頭発表（一般）
- 第76回日本消化器外科学会総会, 2021年07月, 日本語, 国内会議寒冷凝集素症による難治性溶血性貧血に対して脾摘術により治療効果を得た1例口頭発表（一般）
- 第76回日本消化器外科学会総会, 2021年07月, 日本語, 国内会議高度進行肝細胞癌に対する減量切除症例におけるサルコペニアの検討口頭発表（一般）
- 第76回日本消化器外科学会総会, 2021年07月, 日本語, 国内会議肝臓外科におけるDemarcation lineとIntersegmental/sectional plane口頭発表（一般）
- 第76回日本消化器外科学会総会, 2021年07月, 日本語, 国内会議肝S7病変に対する腹腔鏡手術適応の妥当性に関する検討口頭発表（一般）
- 第76回日本消化器外科学会総会, 2021年07月, 日本語, 国内会議高度進行肝細胞癌に対する減量切除術の有用性の検討口頭発表（一般）
- 第39回日本肝移植学会学術集会, 2021年06月, 日本語, 国内会議肝移植後の経時的な体重変化を予測する因子に関する検討口頭発表（一般）
- 第39回日本肝移植学会学術集会, 2021年06月, 日本語, 国内会議肝移植後長期生存を得られたレシピエントにおける年齢の及ぼす影響シンポジウム・ワークショップパネル（公募）
- 第47回日本急性肝不全研究会, 2021年06月, 日本語, 国内会議急性肝不全患者に対する脳死肝移植待機中に腹直筋血腫を合併し管理に難渋した一例口頭発表（一般）
- 第33回日本肝胆膵外科学会学術集会, 2021年06月, 英語, 国内会議Prognosis after total pancreatectomy and total remnant pancreatectomy for pancreatic cancer口頭発表（一般）
- 第33回日本肝胆膵外科学会学術集会, 2021年06月, 英語, 国内会議Demarcation line assessment in anatomical liver resectionシンポジウム・ワークショップパネル（公募）
- 第33回日本肝胆膵外科学会学術集会, 2021年06月, 英語, 国内会議Present status of outpatient clinic for transplant patientsシンポジウム・ワークショップパネル（公募）
- 第33回日本肝胆膵外科学会学術集会, 2021年06月, 英語, 国内会議Impact of hepatectomy for advanced hepatocellular carcinoma with major portal vein tumor thrombusシンポジウム・ワークショップパネル（公募）
- 第33回日本肝胆膵外科学会学術集会, 2021年06月, 英語, 国内会議Long term survival following resection for ampullary carcinomaシンポジウム・ワークショップパネル（公募）
- 第43回日本癌局所療法研究会, 2021年05月, 日本語, 国内会議腎細胞癌の異時性単発肝転移に対し分子標的薬治療後に腹腔鏡下肝切除術を施行した 1 例口頭発表（一般）
- 第43回日本癌局所療法研究会, 2021年05月, 日本語, 国内会議足底原発の未分化多形肉腫膵転移に対して腹腔鏡下尾側膵切除を行った一例口頭発表（一般）
- 第43回日本癌局所療法研究会, 2021年05月, 日本語, 国内会議腹腔鏡下膵体尾部切除後、needle tract seeding による胃壁再発をきたした膵癌の1例口頭発表（一般）
- 第43回日本癌局所療法研究会, 2021年05月, 日本語, 国内会議膵癌に対する亜全胃温存膵頭十二指腸切除術後の挙上空腸間膜再発に切除を施行した1例口頭発表（一般）
- 第121回日本外科学会定期学術集会, 2021年04月, 日本語, 国内会議膵管内乳頭粘液性癌に対する亜全胃温存膵頭十二指腸切除術後に細胆管癌を発症し，肝切除後胆汁瘻を合併した1例ポスター発表
- 第121回日本外科学会定期学術集会, 2021年04月, 日本語, 国内会議肝細胞癌再発に対する腹腔鏡下再肝切除適応の条件についての検討ポスター発表
- 第121回日本外科学会定期学術集会, 2021年04月, 日本語, 国内会議切除を企図し得るカテゴリとしての切除可能境界膵癌の再検討口頭発表（一般）
- 第121回日本外科学会定期学術集会, 2021年04月, 日本語, 国内会議高齢者に対する肝門部領域胆管癌手術の検討ポスター発表
- 第121回日本外科学会定期学術集会, 2021年04月, 日本語, 国内会議進行胆道癌に対する集学的治療とConversion Surgeryの意義ポスター発表
- 日本外科学会定期学術集会抄録集, 2021年04月, 日本語, (一社)日本外科学会膵管内乳頭粘液性癌に対する亜全胃温存膵頭十二指腸切除術後に細胆管癌を発症し、肝切除後胆汁瘻を合併した1例
- 第32回日本肝胆膵外科学会, 2021年02月, 日本語, 国内会議Hyperspectral imaging-based enhanced reality for liver resection口頭発表（一般）
- 日本消化器外科学会雑誌, 2015年10月, 日本語, (一社)日本消化器外科学会大腸癌肝転移に対する肝切除時期についての検討
- HEPATOLOGY, 2013年10月, 英語Dual Treatment; A Novel Strategy for Highly-Advanced Hepatocellular carcinoma
- HEPATOLOGY, 2013年10月, 英語Usefulness of 99mTc-GSA scintigraphy on preoperative evaluation of liver function for hepatectomy
- 日本消化器外科学会雑誌, 2013年10月, 日本語, (一社)日本消化器外科学会3cm、3個以下の肝細胞癌に対する肝切除、生体肝移植の治療成績
- 日本消化器外科学会雑誌, 2013年10月, 日本語, (一社)日本消化器外科学会腹部固形癌に対する粒子線とスペーサー外科手術を用いた治療限界の克服
- International Hepato-Pancreato Biliary Association- 現在
- The European Association of Endoscopic Surgery- 現在
- 日本臨床外科学会- 現在
- 日本癌治療学会- 現在
- 日本肝移植学会- 現在
- 日本移植学会- 現在
- 日本胆道学会- 現在
- 日本肝臓学会- 現在
- 日本内視鏡外科学会- 現在
- 日本肝胆膵外科学会- 現在
- 日本消化器病学会- 現在
- 日本消化器外科学会- 現在
- 日本外科学会- 現在
■ 共同研究・競争的資金等の研究課題
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日ビデオスペクトルカメラを用いた新規肝胆膵外科手術ナビゲーションシステムの研究開発
- 日本学術振興会, 科学研究費助成事業 若手研究, 若手研究, 神戸大学, 2021年04月01日 - 2023年03月31日ハイパースペクトルカメラを用いた次世代肝胆膵外科手術ナビゲーションシステムの確立
- 内視鏡医学研究振興財団, 内視鏡医学研究振興財団研究助成, 神戸大学大学院医学研究科外科学講座肝胆膵外科学分野, 2022年01月 - 2022年12月, 研究代表者ハイパースペクトルカメラを用いた腹腔鏡下肝切除ナビゲーション技術の開発