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裏川 直樹大学院医学研究科 医科学専攻助教
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■ 論文- Anticancer Research USA Inc., 2024年12月, Anticancer Research, 44(12) (12), 5485 - 5493研究論文（学術雑誌）
- Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 101934 - 101934研究論文（学術雑誌）
- Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007研究論文（学術雑誌）
- Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.Wiley, 2024年11月, World Journal of Surgery研究論文（学術雑誌）
- Abstract Developmental cyst is occasionally seen in children but are less common in adults. Complete removal of developmental cyst is necessary because there are risk of infection, squamous cell carcinoma, and recurrence due to incomplete resection. The best approach for resection of developmental cyst is still controversial. Although transsacral approach, open abdominal approach, or a combination of both have been often employed to date, reports of laparoscopic surgery have been appearing in recent years. We performed laparoscopic surgery for four patients with this disease: (i) 29‐year‐old woman with epidermoid cyst; (ii) 21‐year‐old woman with dermoid cyst; (iii) 55‐year‐old woman with epidermoid cyst; and (iv) 77‐year‐old woman with epidermoid cyst. No perioperative complications occurred and no recurrence has developed so far in any patients. Laparoscopic surgery can be considered as one of the optimal treatment options for developmental cyst.Wiley, 2024年11月, Asian Journal of Endoscopic Surgery, 18(1) (1)研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年09月, Surgery Today研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年09月, Esophagus, 22(1) (1), 59 - 67研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年06月, Surgery Today研究論文（学術雑誌）
- Abstract Background Herein, we report a case of gastric antrum cancer with multiple invasions to other organs that was completely cured with laparoscopic distal gastrectomy after preoperative chemotherapy in a patient with poor general condition. Case presentation An 80-year-old male patient was diagnosed with anemia during follow-up for cerebral lacunar infarction at another hospital. He was diagnosed with advanced-stage gastric antrum cancer and was referred to our hospital. On esophagogastroduodenoscopy, type 2 advanced-stage gastric cancer was detected at the greater curvature of the antrum, and the biopsy results revealed tubular adenocarcinoma. Contrast-enhanced computed tomography scan revealed multiple invasions to other organs, thick gastric wall with contrast effect, and superior mesenteric vein tumor thrombus. However, there was no evidence of distant metastasis on positron emission tomography/computed tomography scan. The clinical diagnosis was stage IVA gastric cancer. Pancreatoduodenectomy with portal vein resection could be important at this point. However, preoperative chemotherapy with S-1 and oxaliplatin was administered instead of performing extended surgery because the patient had poor general condition (performance status score of 3). The patient received three cycles of preoperative chemotherapy at the hospital along with rehabilitation and nutritional management with oral nutritional supplements. After treatment, the performance status score of the patient improved from 3 to 1. Furthermore, in terms of clinical therapeutic effect, the patient achieved partial response. Hence, laparoscopic distal gastrectomy with D2 lymph node dissection and partial transverse colectomy was performed. After surgery, the patient was admitted for oral intake on postoperative day 6 and was discharged on postoperative day 21. Based on the histopathological examination, gastric cancer had disappeared, and there were no evident malignant findings. Therefore, gastric cancer was classified as grade 3 according to the histological treatment efficacy criteria. The patient did not present with recurrence at 2 years after surgery. Conclusions By actively administering preoperative chemotherapy, minimally invasive radical surgery with maximum preservation of the surrounding organs can be performed for locally far advanced-stage gastric cancer in older patients with poor general condition.Springer Science and Business Media LLC, 2024年06月, Surgical Case Reports, 10(1) (1)研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年06月, Langenbeck's Archives of Surgery, 409(1) (1)研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年05月, Surgical Endoscopy, 38(7) (7), 3625 - 3635研究論文（学術雑誌）
- Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.Public Library of Science (PLoS), 2024年04月, PLOS ONE, 19(4) (4), e0299742 - e0299742研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2024年02月, Annals of Surgical Oncology, 31(6) (6), 4018 - 4018研究論文（学術雑誌）
- Background/Aim: The relationship between gastric cancer and oral health has been reported in several studies. This study aimed to determine the relationship between the postoperative prognosis of gastric cancer and oral health using preoperative tooth loss as a simple index. Patients and Methods: We conducted a single-center retrospective cohort study. Patients were divided into two groups according to the number of tooth losses. The survival curve was constructed using the Kaplan–Meier method. We also performed univariate and multivariate analyses of overall survival based on Cox proportional hazard regression to determine prognostic factors. Results: A total of 191 patients were divided into two groups: those with seven or more tooth losses and those with less than seven tooth losses. The three-year overall survival rate was 71.5% in the group with seven or more tooth losses and 87.0% in the group with less than seven tooth losses. The group with seven or more tooth losses had a significantly lower overall survival rate compared to the group with less than seven tooth losses (p=0.0014). However, in multivariate analysis, tooth loss was not identified as an independent prognostic factor whereas age, clinical T stage, CEA level, and serum albumin level were independent poor prognostic factors. Conclusion: Preoperative tooth loss was not a prognostic factor for gastric cancer after gastrectomy, but tooth loss may be a simple and useful method for evaluating frailty in patients.Anticancer Research USA Inc., 2024年01月, Cancer Diagnosis & Prognosis, 4(1) (1), 51 - 56研究論文（学術雑誌）
- Anticancer Research USA Inc., 2023年12月, Anticancer Research, 44(1) (1), 229 - 237研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2023年12月, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2023年12月, Surgery Today研究論文（学術雑誌）
- (株)癌と化学療法社, 2023年12月, 癌と化学療法, 50(13) (13), 1370 - 1373, 日本語
- (株)癌と化学療法社, 2023年12月, 癌と化学療法, 50(13) (13), 1374 - 1377, 日本語
- Anticancer Research USA Inc., 2023年11月, Anticancer Research, 43(12) (12), 5649 - 5656研究論文（学術雑誌）
- Abstract There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.Springer Science and Business Media LLC, 2023年10月, Scientific Reports, 13(1) (1)研究論文（学術雑誌）
- BACKGROUND/AIM: In pathology, the digitization of tissue slide images and the development of image analysis by deep learning have dramatically increased the amount of information obtainable from tissue slides. This advancement is anticipated to not only aid in pathological diagnosis, but also to enhance patient management. Deep learning-based image cytometry (DL-IC) is a technique that plays a pivotal role in this process, enabling cell identification and counting with precision. Accurate cell determination is essential when using this technique. Herein, we aimed to evaluate the performance of our DL-IC in cell identification. MATERIALS AND METHODS: Cu-Cyto, a DL-IC with a bit-pattern kernel-filtering algorithm designed to help avoid multi-counted cell determination, was developed and evaluated for performance using tumor tissue slide images with immunohistochemical staining (IHC). RESULTS: The performances of three versions of Cu-Cyto were evaluated according to their learning stages. In the early stage of learning, the F1 score for immunostained CD8+ T cells (0.343) was higher than the scores for non-immunostained cells [adenocarcinoma cells (0.040) and lymphocytes (0.002)]. As training and validation progressed, the F1 scores for all cells improved. In the latest stage of learning, the F1 scores for adenocarcinoma cells, lymphocytes, and CD8+ T cells were 0.589, 0.889, and 0.911, respectively. CONCLUSION: Cu-Cyto demonstrated good performance in cell determination. IHC can boost learning efficiencies in the early stages of learning. Its performance is expected to improve even further with continuous learning, and the DL-IC can contribute to the implementation of precision oncology.2023年08月, Anticancer research, 43(8) (8), 3755 - 3761, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In recent years, the proportion of patients diagnosed with CRC at younger ages has increased. The clinicopathological features and oncological outcomes in younger patients with CRC remain controversial. We aimed to analyze the clinicopathological features and oncological outcomes in younger patients with CRC. METHODS: We examined 980 patients who underwent surgery for primary colorectal adenocarcinoma between 2006 and 2020. Patients were divided into two cohorts: younger (< 40 years old) and older (≥ 40 years old). RESULTS: Of the 980 patients, 26 (2.7%) were under the age of 40 years. The younger group had more advanced disease (57.7% vs. 36.6%, p = 0.031) and more cases beyond the transverse colon (84.6% vs. 65.3%, p = 0.029) than the older group. Adjuvant chemotherapy was administered more frequently in the younger group (50% vs. 25.8%, p < 0.01). Relapse-free survival and overall survival were similar between the groups at all stages. Moreover, in stages II and III they were also comparable, regardless of the administration of adjuvant chemotherapy. CONCLUSIONS: Younger patients with CRC have a prognosis equivalent to that of older patients. Further studies are needed to establish the optimal treatment strategies for these patients.2023年07月, International journal of colorectal disease, 38(1) (1), 191 - 191, 英語, 国際誌研究論文（学術雑誌）
- 2023年07月, Annals of surgical oncology, 30(7) (7), 4056 - 4057, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Retrosternal reconstruction has lower risks for severe postoperative morbidities, such as gastro-tracheal fistula or esophageal hiatal hernia. We have previously reported the laparoscopic retrosternal route creation (LRRC) method, but its safety and efficacy remain unclear. METHODS: In total, 374 patients with esophageal carcinoma who underwent minimally invasive McKeown esophagectomy in the prone position between 2010 and 2021 were retrospectively reviewed. We performed a propensity score-matched analysis with the simple, nearest-neighbor method and no calipers to compare postoperative outcomes and reconstructed gastric conduit functionality between patients who underwent LRRC and counterparts who underwent posterior mediastinal reconstruction. RESULTS: After matching, 62 patients were included in the laparoscopic retrosternal group (LR group) or posterior mediastinal group (PM group). No significant differences were observed between the groups, apart from the number of robot-assisted surgeries, the extent of lymph node dissection, and the method of cervical anastomosis. There were no significant differences in the incidence of Clavien-Dindo grade ≥ 2 complications. Gastro-tracheal fistula (n = 1) and esophageal hiatal hernia (n = 2) occurred in the PM group but not in the LR group. There were no differences in the incidence of pulmonary embolism between the groups (5% vs. 5%). The postoperative anastomotic stenosis rate was similar (16% vs. 27%, p = 0.192). Endoscopic findings of reflux esophagitis (modified Los Angeles classification ≥ M) at 1 year after surgery were significantly better in the LR group (p = 0.037). CONCLUSIONS: LRRC for gastric conduit reconstruction is safe and valuable. It is associated with good reconstructed gastric conduit function.2023年07月, Annals of surgical oncology, 30(7) (7), 4044 - 4053, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: There are several concerns about oncological contamination and technical difficulty in the laparoscopic approach for locally advanced gastric cancer. We aimed to determine the safety and usefulness of laparoscopic gastrectomy for patients with advanced gastric cancer with tumor depth greater than serosal invasion. PATIENTS AND METHODS: Sixty-two laparoscopic and 82 laparotomy gastric cancer cases surgically diagnosed as serosal or other organ invasions intraoperatively between 2011 and 2021 were included. The laparoscopic and open gastrectomy results were compared by propensity score matching using stage, preoperative chemotherapy, curative resection, surgical technique, and age as explanatory variables and laparoscopy and open resection as outcome variables. RESULTS: No difference in median operative time (341 vs. 386 minutes, p=0.24) was observed, but median blood loss (0 vs. 510 ml, p<0.001) and blood transfusion requirement (9.5 vs. 43%, p<0.001) were lower in the laparoscopic group. No difference was observed between the two groups regarding complications. Furthermore, 3-year overall survival was also similar (43 vs. 42%, p=0.74). CONCLUSION: The laparoscopic surgery results are comparable to those of open surgery in treating gastric cancer with T4a or greater depth. In addition, it is minimally invasive with less blood loss, making it a standard approach.2023年07月, Anticancer research, 43(7) (7), 3145 - 3152, 英語, 国際誌研究論文（学術雑誌）
- 2023年06月, Annals of surgical oncology, 30(6) (6), 3803 - 3804, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Although transanal total mesorectal excision (TaTME) is a promising treatment for low rectal cancer, it is considered technically demanding, and the number of cases required to become proficient in TaTME remains unknown. The purpose of this study was to assess the TaTME learning curve based on the total mesorectal excision completion time. STUDY DESIGN: This retrospective analysis comprised 128 individuals who received TaTME between September 2016 and December 2021. The cumulative sum method was used to generate the learning curve. The duration of the procedure from the beginning to the end of the circumferential rendezvous was used to define the total mesorectal excision completion time. RESULTS: The learning curve consists of 3 phases: phase I (learning phase: cases 1 to 38), phase II (consolidation phase: cases 39 to 70), and phase III (maturing phase: cases 71 to 128). As the phases varied, both the overall operative time and total mesorectal excision completion time decreased considerably. Through the 3 phases of TaTME, intraoperative adverse events decreased, and in phase III, none occurred. Only 1 instance of local recurrence occurred during phase III, and none occurred during phase I or II. CONCLUSIONS: After 70 operations, the surgeon could join the mastery phase of TaTME based on the total mesorectal excision completion time. After the mastering phase began, there were no intraoperative negative occurrences. From the beginning, the oncological safety could be guaranteed.2023年05月, Journal of the American College of Surgeons, 236(5) (5), 1054 - 1063, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Narrow pelvis, tumor diameter, and obesity have been reported as clinical variables correlated with the difficulty of conventional laparoscopic low anterior resection (Lap-LAR). A two-team transanal total mesorectal excision (TaTME) approach where the transabdominal and TaTME are performed simultaneously might reduce the difficulty associated with these factors. This study aimed to clarify the factors associated with the longer time required for TME (TME time) in conventional Lap-LAR and a two-team approach for TaTME. METHODS: We analyzed 52 patients with rectal carcinoma treated with Lap-LAR and 35 patients treated with TaTME. We performed simple linear regression analysis to assess the association between TME time and bony pelvic size using 3D pelvimetry, longest tumor diameter, and body mass index (BMI). RESULTS: Linear regression analysis demonstrated a highly significant association between TME time and obstetric conjugate (R2 = 0.098, P = .024) and BMI (R2 = 0.307, P < .001) in the Lap-LAR group, while no significant association was observed in the TaTME group. Male patients, who had a narrower bony pelvis and higher BMI than female patients, had longer TME time than female patients in the Lap-LAR group (213 minutes vs 172 minutes, P = .021), while the TME time of male and female patients did not differ in the TaTME group (122 minutes vs 108 minutes, P = .451). The TME time in the TaTME group was significantly shorter than that in the Lap-LAR group (121 minutes vs 197 minutes, P < .001). CONCLUSION: A two-team TaTME approach provided a shorter TME time compared to conventional Lap-LAR, regardless of pelvic size and BMI.2023年04月, Asian journal of endoscopic surgery, 16(2) (2), 189 - 196, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Esophagectomy for esophageal carcinoma is associated with higher morbidity and mortality rates than other gastrointestinal surgeries. Smoking is an established risk factor for postoperative complications after esophagectomy. This study aimed retrospectively to investigate the impact of smoking status on short- and long-term outcomes for patients undergoing thoracoscopic esophagectomy in the prone position (TEP) for esophageal carcinoma. METHODS: In this study, 234 patients with esophageal carcinoma who underwent TEP between 2012 and 2020 were divided into two groups based on smoking status (current or non-current smokers and the Brinkman index) by patients' declarations. Postoperative complications (Clavien-Dindo classification grade ≥2), overall survival (OS), and disease-free survival (DFS) were compared between smoking statuses. RESULTS: The rates of postoperative complications did not differ significantly between the two groups (current smoker vs non-current smoker; Brinkman index ≥800 vs <800). The rate of postoperative pneumonia was higher in the combination group of current and higher Brinkman index (≥800) smokers than in the other group (25.0 % vs 11.8 %; P = 0.036). Multivariate analysis showed that smoking status was an independent risk factor for postoperative pneumonia (hazard ratio, 0.41; 95 % confidence interval, 0.18-0.93; P = 0.037). According to the long-term outcomes, no significant differences in OS and DFS were observed between the smoking statuses. CONCLUSIONS: The combination of current smoking and heavy smoking history is a risk factor for postoperative pneumonia in patients who have esophageal carcinoma treated with TEP, although no correlation was observed between the long-term outcomes and smoking status.2023年04月, Annals of surgical oncology, 30(4) (4), 2202 - 2211, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Laparoscopic surgery for low rectal cancer is often challenging. Transanal total mesorectal excision (TaTME) and robotic surgery have been introduced to overcome the technical difficulties in laparoscopic surgery and achieve more favorable outcomes. Hybrid robotic surgery, which combines TaTME with the abdominal robotic approach, incorporates the advantages of each of these surgical techniques and might achieve less invasive and safer surgery. This study evaluated the safety and feasibility of hybrid robotic surgery with TaTME (hybrid TaTME). METHODS: We retrospectively reviewed 162 TaTME cases performed at our department from September 2016 to May 2022. Among them, 92 cases of conventional TaTME and 30 of hybrid TaTME were eligible. We used propensity score matching analysis (PSM) to adjust for patients' characteristics and compared the short-term outcomes of the two treatment groups. RESULTS: Twenty-seven cases in each group were extracted using PSM. The operation time in hybrid TaTME was comparable to that in conventional TaTME. There was no significant difference in the postoperative hospital stay between the two groups. Other intra- and post-operative outcomes were also comparable between the two groups. Furthermore, no significant differences were observed between the two groups in the curative resection and recurrence rates. CONCLUSION: Hybrid TaTME for low rectal cancer was as favorable as conventional TaTME in producing satisfactory short-term outcomes. However, furthermore, larger-scale studies conducted over longer study periods are needed to evaluate the validity of the findings.2023年03月, Langenbeck's archives of surgery, 408(1) (1), 129 - 129, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to compare motions of the laparoscope tip during a laparoscopic task in a training box using a recent joystick-guided robotic scope holder to those manipulated by human scopists. We hypothesized that laparoscopic manipulation could be positively affected by robotic scope holders due to the elimination of unintentional movement. METHODS: Twelve surgeons participated as operators, and eight medical doctors participated in this study. Among the human scopists, five were trained surgeons and three were novices who had no experience with laparoscopic surgery. A validated laparoscopic task was used to evaluate the path length of the laparoscope tip using an optical position tracker and operative time. The operators performed the designated camera task under three different laparoscopic manipulations: using a joystick-guided robotic scope holder, expert human scopists, and novice scopists. RESULTS: The median path lengths (cm) of the laparoscopic tip were 94.0, 110.0, and 122.2 in the robotic scope holder, expert, and novice groups, respectively. The path lengths in the robotic scope holder group were significantly shorter than those in the other groups (P < .01). The median operative times (seconds) were 136.6, 66.4, and 62.3 in the robotic scope holder, expert, and novice groups, respectively. The operative time of the robotic scope holder group was significantly longer than that of the other groups (P < .001). CONCLUSION: A robotic scope holder can provide shorter camera movement owing to the stable holding and intentional scope manipulation by the operator, although it requires a longer operative time than a human assistant.2023年02月, Surgical innovation, 15533506231157039 - 15533506231157039, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Although lateral pelvic lymph node dissection (LLND) might be an effective approach for patients with rectal cancer with lateral lymph node metastasis, it is technically challenging because of the anatomical complexity and location of the deep pelvis. An assistance by transanal approach might be useful for a successful LLND. METHODS: From September 2016 to May 2021, 39 patients with low rectal cancer underwent transanal total mesorectal excision with LLND. Among them, 18 patients underwent LLND using a conventional laparoscopic approach alone, while the remaining 21 underwent LLND using both conventional and transanal approaches. Their clinical outcomes were retrospectively compared. RESULTS: The operation time for LLND on each side was significantly shorter in the transanal group (105 min vs. 54 min, P < 0.001). The intraoperative blood loss was also significantly less in the transanal group (40 g vs. 0 g, P = 0.031). The rate of overall postoperative complications ≥ grade II according to the Clavien-Dindo classification was significantly less in the transanal group (66.7% vs. 28.6%, odds ratio: 5.000, 95% confidence intervals: 1.313-19.047, P = 0.040). The number of harvested lateral lymph nodes in both groups was similar (8.5 vs. 8, P = 0.544). CONCLUSION: The transanal approach for LLND reduced operative time, blood loss, and morbidity compared with the conventional approach alone in a cohort of patients with rectal cancer.2023年02月, Surgical endoscopy, 37(2) (2), 1562 - 1568, 英語, 国際誌研究論文（学術雑誌）
- Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal cancer. This study aimed to investigate the association of Wnt/β-catenin signal activation with a pathological response to NACRT. The immunohistochemical expression of nuclear and membranous β-catenin was analyzed in biopsy samples obtained from 60 patients with locally advanced rectal cancer who received curative surgery following NACRT. The association of Wnt/β-catenin signal activation with their clinical outcomes was investigated. Notably, the body mass index of these patients was significantly higher in the low nuclear β-catenin expression group. Moreover, patients in the high nuclear β-catenin expression group tended to have more advanced disease and a higher rate of positive vascular invasion than those in the low expression group. Furthermore, the rate of good histological responses was significantly higher in the low nuclear β-catenin expression group (72% vs. 37.1%, p < 0.01). Overall, relapse-free survival tended to be better in patients with low nuclear/high membranous β-catenin expression (n = 9) than in other individuals (n = 51) (p = 0.093 and p = 0.214, respectively). Activation of the Wnt/β-catenin signal pathway represented by nuclear β-catenin accumulation was significantly associated with a poor response to NACRT in patients with rectal cancer. Analysis of nuclear β-catenin accumulation before starting treatment might help predict the therapeutic response to NACRT.2023年01月, Biomedicines, 11(1) (1), 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Neoadjuvant chemotherapy (NAC) for advanced gastric cancer (GC) and esophagogastric junction cancer (EGC) is expected to effectively control the tumor; however, histological tumor response and immune function markers as prognostic factors for NAC remain unknown. This study assessed the prognostic significance of histological response and immune function markers in patients undergoing NAC for GC and EGC. PATIENTS AND METHODS: Forty-two patients who underwent NAC followed by surgical resection for operable advanced GC or EGC from January 2007 to December 2019 were divided into two groups based on histological response. Overall survival (OS), tumor response, and immune function markers, such as the neutrophil/lymphocyte ratio (NLR), were the outcomes analyzed. RESULTS: The 5-year OS for Grade 2b-3 (n=10, responder group) according to the Japanese Gastric Cancer Classification was 72.0% with a favorable prognosis, compared with 33.3% for Grade 0-1a (n=18), and 46.8% for Grade 1b-2a (n=14) in the non-responder group. There was no significant difference in the background between the two groups regarding clinical status or immune function markers. In a multivariate analysis of immune function markers, the NLR value before NAC was significantly associated with prognosis (p=0.048). Patients with an NLR value <3.4 had a favorable OS (p=0.03). CONCLUSION: Histological response scores for Grade 2b or higher may help predict a favorable prognosis for patients undergoing NAC for advanced GC and EGC. The outcomes may be further improved by considering NLR values.2023年, In vivo (Athens, Greece), 37(1) (1), 378 - 384, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Rectal or anal canal adenocarcinoma with inguinal lymph node metastasis (ILNM) is rare and is associated with poor prognostic outcomes. This study aimed to elucidate the clinical significance of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for rectal or anal canal adenocarcinoma with clinically suspected ILNM. METHODS: This study enrolled 15 consecutive patients who underwent neoadjuvant therapy and curative resection for rectal or anal canal adenocarcinoma with clinically suspected ILNM between 2005 and 2019 at a single institution. Inguinal lymph node dissection was selectively performed on the side of suspected metastasis before neoadjuvant therapy. Short- and long-term outcomes were retrospectively reviewed. RESULTS: Out of the15 patients, 11 were treated with neoadjuvant chemoradiation, three with chemotherapy, and one with chemoradiation followed by chemotherapy. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) scans were performed after neoadjuvant therapy in 14 patients. Five patients had negative FDG accumulation in inguinal lymph nodes on FDG-PET scan, and their inguinal lymph nodes were also pathologically negative for metastasis. Of the nine patients who had positive FDG accumulation, four had pathologically positive inguinal lymph nodes. Seven patients (46.7%) had inguinal seroma postoperatively. Five-year-overall survival was 77.5%, and 5-year-relapse-free survival was 64.2%. No patient had a recurrence in the inguinal region. CONCLUSION: In patients with rectal or anal canal adenocarcinoma associated with clinical ILNM, radical resection with neoadjuvant therapy provides a good long-term survival.2022年12月, Langenbeck's archives of surgery, 408(1) (1), 2 - 2, 英語, 国際誌研究論文（学術雑誌）
- Obesity, a known risk factor for various types of cancer, reduces the number and function of cytotoxic immune cells in the tumor immune microenvironment (TIME). However, the impact of obesity on CD4+ T cells remains unclear. Therefore, this study aimed to clarify the impact of obesity on CD4+ T cells in the TIME. A tumor-bearing obese mouse model was established by feeding with 45% high-fat diet (HFD), followed by inoculation with a colon cancer cell line MC38. Tumor growth was significantly accelerated compared to that in mice fed a control diet. Tumor CD4+ T cells showed a significant reduction in number and an increased expression of programmed death-1 (PD-1), and decreased CD107a expression and cytokine such as IFN-γ and TNF-α production, indicating dysfunction. We further established CD4+ T cell-depleted HFD-fed model mice, which showed reduced tumor infiltration, increased PD-1 expression in CD8+ T cells, and obesity-induced acceleration of tumor growth in a CD4+ T cell-dependent manner. These findings suggest that the reduced number and dysfunction of CD4+ T cells due to obesity led to a decreased anti-tumor response of both CD4+ and CD8+ T cells to ultimately accelerate the progression of colorectal cancer. Our findings may elucidate the pathogenesis for poor outcomes of colorectal cancer associated with obesity.2022年12月, Cells, 12(1) (1), 英語, 国際誌研究論文（学術雑誌）
- (株)癌と化学療法社, 2022年12月, 癌と化学療法, 49(13) (13), 1711 - 1713, 日本語
- [A Case of Pathological Complete Response after Conversion Surgery for HER2-Positive Advanced Gastric Cancer with Multiple Distant Metastases].The patient is a 70's man. Esophagogastroduodenoscopy and contrast-enhanced CT scan of the abdomen revealed gastric cancer, 2 liver metastases, and peritoneal dissemination. He was diagnosed with unresectable advanced gastric cancer and received 5 courses of chemotherapy(CapeOX plus T-mab). The primary tumor size had reduced, and liver metastases and peritoneal dissemination were not detectable, so laparoscopic distal gastrectomy and partial hepatectomy were performed. Histopathological findings revealed no viable cancer cells in either the primary tumor or the hepatic resection site, and the histological response was Grade 3. The patient has been recurrence-free for 6 months since the surgery. Even in Stage Ⅳ gastric cancer with multiple distant metastases, long-term survival may be expected by conversion surgery after response to chemotherapy.2022年12月, Gan to kagaku ryoho. Cancer & chemotherapy, 49(13) (13), 1711 - 1713, 日本語, 国内誌研究論文（学術雑誌）
- PURPOSE: Despite the increasing incidence of adenocarcinoma of the esophagogastric junction, laparoscopic proximal gastrectomy with lower esophagectomy (PGLE) is not widely accepted owing to the lack of standardized reconstruction techniques. In this study, we developed a new reconstruction method named y-shaped overlap esophagogastric tube reconstruction, which reproduces an angle of His and a pseudo-fornix, to be used in laparoscopic transhiatal PGLE. This study aimed to determine the feasibility of this novel reconstruction method. METHODS: This retrospective study included the analysis of short- and mid-term surgical outcomes of 30 consecutive patients with Siewert type II esophagogastric junction adenocarcinoma who underwent laparoscopic PGLE with y-shaped overlap esophagogastric tube reconstruction from April 2015 to August 2020. A novel method was used to form a 6-cm pseudo-fornix and an angle of His using the distal esophagus and a long gastric tube. RESULTS: The median operation time was 369 min, and the median blood loss was 28 mL. The median follow-up period after surgery was 37 months. Although two patients experienced postoperative anastomotic leakage, none of the patients developed stenosis. One patient experienced moderate reflux symptoms, whereas four patients developed moderate reflux esophagitis based on the 1-year follow-up endoscopic examination; the condition of all patients could be efficiently controlled with medication. CONCLUSION: The short- and mid-term surgical outcomes of y-shaped overlap esophagogastric tube reconstruction reflected the feasibility of this simple technique and suggested its potential utility as a reconstruction alternative for Siewert type II tumors.2022年12月, Langenbeck's archives of surgery, 407(8) (8), 3915 - 3915, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Many patients with esophageal squamous cell carcinoma (ESCC) have obstructive ventilatory disorder (OVD), which is considered a risk factor for postoperative pneumonia. It has been reported that thoracoscopic esophagectomy in the prone position (TEP) is less invasive and is associated with fewer postoperative respiratory complications compared with open esophagectomy. This matched-cohort study aimed to elucidate the safety and oncologic outcomes of ESCC patients with OVD who undergo TEP. METHODS: In this matched-cohort study, 237 patients with ESCC who underwent TEP between 2010 and 2018 were divided into two groups based on forced expiratory volume in 1 s/forced vital capacity. Postoperative complications (Clavien-Dindo classification grade II or higher), overall survival (OS), and disease-free survival (DFS) were compared between the two groups. RESULTS: Based on their propensity scores, 75 patients with normal respiratory function (NRF) and 75 with OVD were selected. The rates of postoperative pneumonia were not significantly different between the two groups (NRF group vs OVD group: 18.7% vs 18.7%; P = 1.000). The rates of recurrent laryngeal nerve palsy and anastomotic leakage were also not significantly different (NRF group vs OVD group: 12.0% vs 18.7%, P = 0.365; 18.7% vs 18.7%, P = 1.000). The 5-year OS and DFS rates in the NRF vs OVD groups were 66.2% vs 54.9% and 63.5% vs 52.9%, respectively, with no significant differences (P = 0.421, 0.197). CONCLUSIONS: TEP can be safely performed on ESCC patients with OVD and can result in an oncological efficiency equal to that of the NRF group.2022年12月, Surgical endoscopy, 36(12) (12), 8834 - 8842, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Although survival in cases with early recurrence after curative resection of colorectal cancer has been persistently poor, the risk factors for early recurrence remain unknown. PATIENTS AND METHODS: A total of 1,043 patients with stage I-III colorectal cancer underwent curative resection at Kobe University Hospital between April 2007 and September 2020. Of these, 122 patients developed recurrence: 57 had early recurrence (<1 year after surgery) and 65 patients had late recurrence (≥1 year after surgery). The clinicopathological features were compared between the groups and the risk factors for early recurrence were analyzed. RESULTS: Overall survival both from the date of recurrence and from the date of surgery were significantly worse in the early recurrence group. The proportion of the patients with ≥100 g of intraoperative blood loss, blood transfusion, and postoperative complications were significantly higher in the early recurrence group. R0 resection was achieved more frequently in the late recurrence group. Multivariate analysis revealed that no adjuvant chemotherapy, elevated preoperative CA19-9, blood transfusion, and the occurrence of the postoperative complication were independent risk factors for early recurrence. CONCLUSION: Early recurrence after curative resection of colorectal cancer was associated with worse overall survival. Adjuvant chemotherapy might be beneficial for patients with risk factors of early recurrence to improve prognosis.2022年11月, Anticancer research, 42(11) (11), 5553 - 5559, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: No study has focused on the safety and feasibility of our previously developed open-window suturing technique to close mucosal defects on the pancreatic side after endoscopic submucosal dissection from the opened duodenal wall. This study aimed to evaluate the safety and usefulness of laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side of the duodenum. METHODS: This retrospective study included 61 consecutive patients who underwent surgery during August 2014-November 2021. After dissection when the tumor was on the pancreatic side, we sutured the mucosal defect from the opened duodenal wall. A preoperative endoscopic pancreatic stent was placed for tumors within 1 cm of the ampulla of Vater. The surgical outcomes were compared between tumors on the pancreatic and non-pancreatic sides. RESULTS: There were 27 and 34 patients with tumors on the pancreatic and non-pancreatic sides, respectively. The patient characteristics were similar. Preoperative pancreatic stents were placed in four patients in the pancreatic side group. The median operative time was significantly longer on the pancreatic side than in the non-pancreatic side group (241 vs. 209 min, P = 0.02). In one patient in the pancreatic side group, an intraoperative injury of the ampulla of Vater was successfully treated with intraoperative management. There were no significant differences in the incidence of postoperative grade II or higher complications between the groups. CONCLUSIONS: Laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side is safe and feasible.2022年11月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2266 - 2273, 英語, 国際誌研究論文（学術雑誌）
- 2022年10月, Annals of surgical oncology, 29(11) (11), 6867 - 6868, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Multidisciplinary treatment combining neoadjuvant treatment (NAT) and surgery has slightly improved the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Although various biomarkers targeting nutrition and inflammation are associated with cancer prognosis, most studies have focused on conditions prior to NAT. Developing real-time and sensitive biomarkers that monitor changes in systemic conditions during NAT is important. We established a novel nutritional and inflammatory index, represented as the albumin to derived neutrophil-to-lymphocyte ratio (Alb-dNLR), and calculated the change in Alb-dNLR (ΔAlb-dNLR) during neoadjuvant chemotherapy (nCT). In this study, we aimed to evaluate whether ΔAlb-dNLR is associated with prognosis in patients with ESCC. METHODS: We investigated 172 patients who underwent nCT before esophagectomy between April 2010 and March 2018. The dNLR was calculated as the ratio of neutrophil count to (white blood cell count - neutrophil count), Alb-dNLR was calculated by dividing the serum albumin level by the dNLR, and ΔAlb-dNLR was evaluated by dividing the post-Alb-dNLR by the pre-Alb-dNLR. Patients were divided into 'high' and 'low' groups according to the ΔAlb-dNLR. RESULTS: Thirty-nine patients (22.7%) had a low ΔAlb-dNLR (≤ 0.8), and the 5-year overall survival (OS) rates in patients with low and high ΔAlb-dNLR were 38.1% and 53.6%, respectively (p = 0.0072). Multivariate analyses demonstrated that estimated blood loss (p = 0.044), pathological T stage (p = 0.0005), pathological N stage (p = 0.017), and ΔAlb-dNLR (p = 0.005) were independent prognostic factors for OS. CONCLUSIONS: ΔAlb-dNLR is a useful prognostic factor for OS in patients with ESCC receiving nCT.2022年10月, Annals of surgical oncology, 29(11) (11), 6860 - 6866, 英語, 国際誌研究論文（学術雑誌）
- 2022年10月, Annals of surgical oncology, 29(11) (11), 6869 - 6870, 英語, 国際誌研究論文（学術雑誌）
- The risk factors for delayed gastric emptying (DGE) following gastrectomy are unclear. This study aimed to investigate the risk factors for DGE and the severity of DGE. We retrospectively evaluated 412 patients who underwent gastrectomy for gastric cancer between 2011 and 2019. The cases were classified into the DGE (n = 27) and non-DGE (n = 385) groups; the DGE group was further classified into two subgroups based on nasogastric tube insertion as an indicator of severity. For determining the relationship between resected stomach volume and DGE, we calculated the area of each surgical specimen using the ImageJ software. Female sex (odds ratio [OR] 2.55; 95% confidence interval [CI] 1.09-5.93; P = 0.03), diabetes (OR 2.38; 95% CI 1.02-5.57; P = 0.03), and distal gastric tumors (OR 2.61; 95% CI 1.10-6.19; P = 0.02) were identified as independent risk factors by multivariate analysis. The duration of hospital stay was longer in the DGE group than in the non-DGE group (29 vs. 15 days, P < 0.01). Overall, 24 cases of DGE (89%) were found in more than 1 week following surgery. No correlation was observed between clinical features and the severity of DGE. The resected area in the DGE group was significantly larger than that in the non-DGE group (198.0 vs. 173.9 cm2, P = 0.03). In conclusion, DGE was frequently observed in females and in patients with diabetes and distal gastric tumors. Most of the DGE cases occurred after 7-14 days of surgery, patients who are discharged early should be informed to seek hospitalization if they have symptoms caused by DGE.2022年09月, Scientific reports, 12(1) (1), 15903 - 15903, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor node metastasis (AJCC-TNM 8th) system adopted the newly separate post-neoadjuvant pathologic stage group (ypTNM). However, it is not compatible with the Japanese pathologic classification after neoadjuvant chemotherapy (JPN-CT-pTNM). The aim of this study is to clarify the subjects of the AJCC-ypTNM 8th and propose a unification of the AJCC and Japanese systems to create novel AJCC-CT-pTNM 8th. METHODS: Participants were 304 esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemotherapy followed by 3 stage esophagectomy between 2010 and 2019. Predictive probabilities of pN, pM in AJCC-ypTNM 8th and JPN-CT-pTNM 11th systems were evaluated to propose novel system. RESULTS: In training data from 234 patients, the overall survival rate was statistically better for ypStage IIIA than ypStage II (P = 0.040) resulting in staging inversion in AJCC-ypTNM 8th. Predictive probability of pathological N status in AJCC-ypTNM 8th (Akaike Information Criterion: AIC = 979.53) was superior to that in JPN-CT-pTNM 11th (AIC = 999.07). In AJCC-ypTNM 8th, 71% (15/21) of ypM1 diseases were supraclavicular lymph nodes (No. 104 L/N as regional in JPN-CT-pTNM 11th) metastases with considerably good prognosis. The predictive probability of the novel AJCC-CT-pTNM 8th [unification of ypStage II and IIIA, conversion of supraclavicular L/Ns metastases from ypM to ypN] (AIC = 1054.24) was superior to that of the existing AJCC-ypTNM 8th (AIC = 1070.74). The feasibility of novel system was validated using test data from 70 patients. CONCLUSIONS: Unification of the AJCC and Japanese systems yields a simpler and more precise predictive system after neoadjuvant chemotherapy.2022年08月, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(8) (8), 1760 - 1767, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Despite the increasing incidence of adenocarcinoma of the esophagogastric junction, laparoscopic proximal gastrectomy with lower esophagectomy (PGLE) is not widely accepted owing to the lack of standardized reconstruction techniques. In this study, we developed a new reconstruction method named y-shaped overlap esophagogastric tube reconstruction, which reproduces an angle of His and a pseudo-fornix, to be used in laparoscopic transhiatal PGLE. This study aimed to determine the feasibility of this novel reconstruction method. METHODS: This retrospective study included the analysis of short- and mid-term surgical outcomes of 30 consecutive patients with Siewert type II esophagogastric junction adenocarcinoma who underwent laparoscopic PGLE with y-shaped overlap esophagogastric tube reconstruction from April 2015 to August 2020. A novel method was used to form a 6-cm pseudo-fornix and an angle of His using the distal esophagus and a long gastric tube. RESULTS: The median operation time was 369 min, and the median blood loss was 28 mL. The median follow-up period after surgery was 37 months. Although two patients experienced postoperative anastomotic leakage, none of the patients developed stenosis. One patient experienced moderate reflux symptoms, whereas four patients developed moderate reflux esophagitis based on the 1-year follow-up endoscopic examination; the condition of all patients could be efficiently controlled with medication. CONCLUSION: The short- and mid-term surgical outcomes of y-shaped overlap esophagogastric tube reconstruction reflected the feasibility of this simple technique and suggested its potential utility as a reconstruction alternative for Siewert type II tumors.2022年08月, Langenbeck's archives of surgery, 407(5) (5), 1881 - 1890, 英語, 国際誌研究論文（学術雑誌）
- In recent years, the usefulness of neoadjuvant chemotherapy for resectable advanced gastric cancer, particularly stage III, has been reported. Preoperative staging is mainly determined by computed tomography (CT), and the usefulness of 18F-fluoro-2-deoxyglucose positron emission tomography/CT (FDG-PET/CT) for gastric cancer has been limited in usefulness. The study aimed to evaluate the usefulness of FDG-PET/CT in preoperative diagnosis of advanced gastric cancer. We retrospectively enrolled 113 patients with gastric cancer who underwent preoperative FDG-PET/CT. All patients underwent gastrectomy with lymph-node dissection. The maximum standardized uptake value (SUVmax) of the primary tumor (T-SUVmax) and lymph nodes (N-SUVmax) were measured for all patients. The cutoff values of T-SUVmax for pathological T3/4 from receiver operating characteristic analysis were 8.28 for differentiated and 4.32 for undifferentiated types. The T-SUVmax and N-SUVmax cutoff values for pathological lymph-node metastasis were 4.32 and 1.82, respectively. Multivariate analysis showed that T-SUVmax for differentiated types was a significant predictor of pathological T3/4, and N-SUVmax was a significant predictor of lymph-node metastasis. In conclusion, the SUVmax of FDG-PET/CT was a useful predictor of pathological T3/4 and lymph-node metastasis in gastric cancer. The diagnosis by preoperative FDG-PET/CT is promising to contribute a more accurate staging of gastric cancer than by CT scan alone.2022年07月, Scientific reports, 12(1) (1), 11370 - 11370, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Postoperative complications affect long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC). Although a comprehensive estimator can predict long-term prognosis, the Clavien-Dindo classification system, a widely used approach to evaluate complications, assesses each complication individually. We aimed to clarify the utility of the comprehensive complication index (CCI) on predicting the overall survival (OS) of patients with ESCC following minimally invasive esophagectomy (MIE). METHODS: This was a retrospective study of patients undergoing MIE for ESCC in the prone position between January 2011 and December 2018. Multivariate analyses using the Cox proportional hazards model were performed to determine independent risk factors for OS. RESULTS: The study cohort included 229 patients who were categorized into patients with CCI values of ≥ 33.7 (CCI high) and < 33.7 (CCI low) by receiver-operating characteristic (ROC) curve analysis. There were no significant differences between the two groups according to clinicopathological factors, such as sex, age, tumor location, tumor depth, lymph node metastasis, and neoadjuvant chemotherapy. The intraoperative transfusion rate in the CCI high group was significantly higher than in the CCI low group. The 5 year OS rate was significantly lower in the CCI high group than in the CCI low group (49.5% vs. 65.7%, p = 0.030). By multivariate analyses, age, tumor depth, lymph node metastasis, and the CCI were independent predictors of OS. CONCLUSIONS: Comprehensive assessment of postoperative complications using the CCI was useful in predicting OS of patients undergoing MIE for the ESCC.2022年07月, Esophagus : official journal of the Japan Esophageal Society, 19(3) (3), 410 - 416, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Technical difficulties are occasionally encountered when performing conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy in patients with a narrow thoracic cavity. Thoracic cavity-to-cage ratio is an indicator of thoracic cavity length. We hypothesized that the thoracic cavity-to-cage ratio could be a predictor of technical difficulties in conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy. METHODS: We evaluated 340 patients who underwent minimally invasive esophagectomy for esophageal squamous cell carcinoma between April 2010 and March 2021. Thoracic cavity-to-cage ratio was calculated as the diameter of the thoracic cavity to that of the thoracic cage at the brachiocephalic vein, tracheal bifurcation, and inferior right pulmonary vein levels. Moreover, thoracic cavity-to-cage ratio score, which is an indicator of the whole thoracic cavity length based on the thoracic cavity-to-cage ratio at the 3 levels, was defined. The thoracic procedure time was considered an indicator of surgical difficulty. RESULTS: We divided the patients into the conventional minimally invasive esophagectomy (n = 295) and robot-assisted minimally invasive esophagectomy (n = 45) groups. The patients in each group were divided into 2 cohorts according to median thoracic procedure time. Based on multivariate analysis, body mass index (P = .0007), clinical N stage (P = .0191), and thoracic cavity-to-cage ratio score (P = .0005) were independent factors for thoracic procedure time in the conventional minimally invasive esophagectomy group. Moreover, thoracic cavity-to-cage ratio at the tracheal bifurcation level (P = .0331) was the only independent factor for thoracic procedure time in the robot-assisted minimally invasive esophagectomy group. CONCLUSION: Thoracic cavity-to-cage ratio could be a predictor of technical difficulties in both conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy.2022年07月, Surgery, 172(1) (1), 145 - 149, 英語, 国際誌研究論文（学術雑誌）
- (株)南江堂, 2022年06月, 外科, 84(7) (7), 715 - 718, 日本語
- 2022年06月, Ann Surg Oncol, 29(6) (6), 3683ASO Visual Abstract: Actual Sarcopenia Reflects Poor Prognosis in Patients with Esophageal Cancer
- BACKGROUND: Minimally invasive esophagectomy (MIE) for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; however, the relationship between sarcopenia and the survival of esophageal cancer patients remains controversial. In this study, we aimed to develop a stratifying marker for sarcopenia to precisely predict patients' prognosis. METHODS: We retrospectively studied 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were preoperatively diagnosed with or without sarcopenia based on the Asian Working Group for Sarcopenia index. Creatinine levels and albumin as measures of skeletal muscle volume and nutritional status, respectively, were used to develop a marker to be used for stratifying sarcopenic patients based on prognosis. RESULTS: Of the 135 patients, 35 were diagnosed with sarcopenia and 100 were not. We combined the creatinine and albumin levels (Cr × Alb) as a stratifying marker for sarcopenia, and extracted sarcopenic patients with values below the Cr × Alb cut-off as the actual sarcopenic group. The 5-year overall survival (OS) rates of the actual and non-actual sarcopenic groups were 28.9% and 58.9%, respectively (p = 0.0005), and the 5-year disease-free survival rate of the actual sarcopenic group was 34.1%, and 62.8% (p = 0.0106) for the non-actual sarcopenic group. This stratified sarcopenia model was an independent prognostic factor and was superior to sarcopenia alone for OS. CONCLUSIONS: In patients undergoing MIE, preoperative measurement of Cr × Alb may be a prognostic stratification marker for patients with sarcopenia.2022年06月, Annals of surgical oncology, 29(6) (6), 3670 - 3681, 英語, 国際誌研究論文（学術雑誌）
- Although transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.2022年05月, Annals of surgical oncology, 29(5) (5), 3065 - 3065, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). PATIENTS AND METHODS: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). RESULTS: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR ≥169.6 had worse 5-year OS rates (31.1%) than those with a PLR <169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of ≥169.6 was an independent factor for poor prognosis. CONCLUSION: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.2022年05月, Anticancer research, 42(5) (5), 2775 - 2782, 英語, 国際誌研究論文（学術雑誌）
- 2022年05月, Surgical endoscopy, 36(5) (5), 3676 - 3676, 英語, 国際誌
- BACKGROUND: Whether surgical device usage in laparoscopic gastrectomy differs with respect to operator's skill levels is unknown. Further, device usage analysis using artificial intelligence has not been reported to date. Herein, we compared the patterns of surgical device usage during laparoscopic gastrectomy for gastric cancer among surgeons at different skill levels. The data of device usage was acquired from laparoscopic video recordings using an automated surgical-instrument detection system. METHODS: In total, 100 video recordings of infrapyloric lymphadenectomy and 33 of D2 suprapancreatic lymphadenectomy during laparoscopic gastrectomy for gastric cancer were analyzed in this retrospective study. The system's accuracy was evaluated by comparing the automatic and the manual usage time. Surgical device usage patterns were compared between qualified and nonqualified surgeons of The Japan Society for Endoscopic Surgery Endoscopic Surgical Skill Qualification System. RESULTS: For every device, the automatic detection time and manual detection time were consistent with each other. In infrapyloric lymphadenectomy, the usage time proportions of dissector forceps and clip applier were higher among nonqualified operators than among qualified operators (dissector, 5.1% vs. 2.3%, P < 0.001; clip applier, 1.6% vs. 1.3%, P < 0.01). In suprapancreatic lymphadenectomy, the usage time proportions of energy devices, clip applier, and grasper forceps were significantly different (energy devices, 59.6% vs. 50.6%, P < 0.001; clip applier, 1.4% vs. 0.9%, P < 0.001; only grasper forceps; 18.3% vs. 27.9%, P = 0.022). CONCLUSIONS: Quantitative analysis of laparoscopic device usage using the automated surgical device detection system showed that the patterns of device usage during laparoscopic gastrectomy differed depending on surgeons' skill levels. These differences could suggest how the qualified and nonqualified surgeons performed the procedures.2022年05月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(5) (5), 1006 - 1014, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Retrosternal reconstruction is associated with a lower risk of mediastinitis, gastro-tracheal fistula, and hiatal hernia. Historically, traumatic manual creation of the retrosternal tunnel has been performed using one's fist. We report a novel and atraumatic laparoscopic procedure to create the retrosternal route. METHODS: We have laparoscopically created the retrosternal route in 25 thoracoscopic, mediastinoscopic, or robot-assisted minimally invasive esophagectomies since August 2019. Specifically, a peritoneal incision is started at the dorsal side of the xiphoid process. Through a 12-mm port inserted slightly to the right of and superior to the umbilical camera port, we dissect loose connective tissues from the caudal to the cranial side using behind the sternum and inside the internal thoracic vessels as landmarks. The time required to create the route was calculated. Then, the cumulative sum (CUSUM) method and the simple moving average of five cases were used to evaluate the learning curve of this novel procedure. Operative outcomes were analyzed according to the learning curve results and also compared with 25 cases of postmediastinal reconstruction counterparts. RESULTS: Twenty-five patients were divided into the early group (six patients) and late group (19 patients) based on the peak of the CUSUM chart. The time required for route creation was 28.5 min (median) in the early and 15 min in the late group, indicating a significant difference (P = 0.038). The overall incidence of pleural injury was 20% (5 of 25 patients), with no significant difference between the groups. There was no significant difference in the incidence of perioperative complications. Also, there were no significant differences in perioperative complications or gastric conduit functions 1 year after surgery between the retrosternal and the postmediastinal reconstruction. CONCLUSION: Laparoscopic creation of a retrosternal route for gastric conduit reconstruction is safe and feasible and has a short learning curve.2022年04月, Surgical endoscopy, 36(4) (4), 2680 - 2687, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Recently, sarcopenia has been reported to be associated with poor postoperative outcomes in various cancers. However, its clinical significance for rectal cancer patients undergoing neoadjuvant chemoradiotherapy (NACRT) followed by surgery remains unknown. MATERIALS AND METHODS: This study included 46 patients with locally advanced rectal cancer who underwent curative surgery after NACRT. Sarcopenia was assessed by measuring the cross-sectional psoas muscle area (PA) at L3 and total bilateral psoas muscle volume (PV). Patients with a lower PV or PA value than the median were assigned to the sarcopenia group while others were assigned to the non-sarcopenia group. Clinical outcomes were then compared between groups. RESULTS: The sarcopenia group included 22 patients. The rate of overall postoperative complications did not differ between groups. Five-year relapse-free survival (RFS) was significantly lower in the sarcopenia group when sarcopenia was assessed by PV after NACRT (44.0% vs. 82.6%, P = 0.00494). In contrast, RFS did not differ between groups when sarcopenia was assessed by PA. Multivariable analysis identified PV after NACRT as the most significant risk factor for RFS (hazard ratio 4.00; 95% CI 1.27-12.66, P = 0.018). CONCLUSION: Sarcopenia assessed by total PV after NACRT may be an accurate and reliable predictor of poor oncological outcomes in rectal cancer patients.2022年04月, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(4) (4), 850 - 856, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Multidisciplinary treatment for esophageal squamous cell carcinoma (ESCC) has improved outcomes, but the prognosis for ESCC remains poor. Nutritional and inflammatory indicators are reported to be associated with cancer prognosis. The combination of albumin and the derived neutrophil-to-lymphocyte ratio (Alb-dNLR) score was established to measure the immune system and nutritional status. The authors hypothesized that the Alb-dNLR score could be a new reliable prognostic factor for ESCC patients. METHODS: The study evaluated 269 patients who underwent esophagectomy between April 2010 and March 2018, including 185 patients who received neoadjuvant chemotherapy. The Alb-dNLR score was calculated using serum albumin and the dNLR. The dNLR was calculated as neutrophils to (leukocyte-neutrophil count). The cutoff values of the albumin and dNLR for overall survival (OS) were determined using the receiver operating characteristic curve. Patients were divided into "high" and "low" groups according to the Alb-dNLR score. RESULTS: A high Alb-dNLR score was found in 61 cases (22.7%). The 5-year OS was 34% in the high Alb-dNLR group and 66.2% in the low Alb-dNLR group (p < 0.0001). The 5-year cause-specific survival (CSS) was 51.5% in the high Alb-dNLR group and 74.7% in the low Alb-dNLR group (p < 0.0001). Multivariate analyses demonstrated that the Alb-dNLR score was an independent prognostic factor for OS (hazard ratio [HR], 2.198; 95% confidence interval [CI], 1.460-3.263; p = 0.0002) and CSS (HR, 1.733; 95% CI, 1.035-2.835; p = 0.0371). CONCLUSIONS: The Alb-dNLR score is an extremely useful, easy-to-use parameter to predict OS and CSS for ESCC patients.2022年04月, Annals of surgical oncology, 29(4) (4), 2663 - 2671, 英語, 国際誌研究論文（学術雑誌）
- 2022年03月, Diseases of the colon and rectum, 65(3) (3), e175, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: This study aimed to examine the efficacy of surgical intervention after chemotherapy for stage IV gastric cancer and the predictors of survival after surgical intervention. PATIENTS AND METHODS: Forty-three gastric cancer patients who had only one type of incurable factor (e.g., para-aortic lymph node metastasis) and had undergone initial chemotherapy, underwent chemotherapy alone (CX group; n=25), palliative gastrectomy (PS group; n=8), and conversion surgery (CS group; n=10). Their therapeutic outcomes were compared. RESULTS: The CS group had significantly higher 2-year overall survival rates (80%) than the CX group (25%), whose prognosis was similar to that of the PS group (23%; p<0.001). Pathological complete response of para-aortic lymph node or peritoneal metastases was an independent predictor of survival after surgery, as was >6 months of chemotherapy. CONCLUSION: CS may improve the prognosis of patients with stage IV gastric cancer in whom chemotherapy can achieve pathological disappearance of the metastatic lesions.2022年03月, Anticancer research, 42(3) (3), 1541 - 1546, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Laparoscopic local resection for gastrointestinal stromal tumors (GISTs) near the esophagogastric junction (EGJ) increases the risk of injuring the EGJ. We investigated the safety of laparoscopic local resection for GISTs near the EGJ according to the distance from the EGJ to the tumor edge. METHODS: We retrospectively evaluated 40 patients who had undergone laparoscopic local resection for GISTs near the EGJ between January 2009 and December 2019. After excluding 1 patient who had undergone right colectomy at the same time, 39 patients were classified according to distance of the GIST from the EGJ in the Near group (0-2.0 cm; n = 16) and the Far group (2.1-5.0 cm; n = 23). RESULTS: We found no marked differences in the operation time, blood loss, length of postoperative hospital stay, or postoperative complication rate in the two groups. Anastomotic leakage occurred with a tumor located on the EGJ. Three tumors recurred in the Near group, and all of them were located on the EGJ. CONCLUSION: Except for GISTs located on the EGJ, laparoscopic local resection for GISTs near the EGJ can be performed safely with few postoperative complications and a low risk of recurrence.2022年03月, Surgery today, 52(3) (3), 395 - 400, 英語, 国内誌研究論文（学術雑誌）
- The maternal/uniparental inheritance of mitochondria is controlled by the selective elimination of paternal/uniparental mitochondria and digestion of their mitochondrial DNA (mtDNA). In isogamy, the selective digestion of mtDNA in uniparental mitochondria is initiated after mating and is completed prior to the elimination of mitochondria, but the molecular mechanism of the digestion of uniparental mtDNA remains unknown. In this study, we developed a semi-in vitro assay for DNase, wherein the digestion of mitochondrial nucleoids (mt-nucleoids) was microscopically observed using isolated mitochondria from Physarum polycephalum and the DNase involved in uniparental inheritance was characterized. When myxamoebae of AI35 and DP246 are crossed, mtDNA and mt-nucleoid from only the DP246 parent are digested. The digestion of mt-nucleoids was observed in zygotes 3 h after plating for mating. During the digestion of mt-nucleoids, mitochondrial membrane integrity was maintained. In the semi-in vitro assay, the digestion of mt-nucleoids was only observed in the presence of Mg2+ at pH 7.5-9.0. Moreover, such Mg2+-dependent DNase activity was specifically detected in mitochondria isolated from zygotes 3 h after plating for mating. Therefore, Mg2+-dependent DNase is potentially involved in uniparental inheritance. Our findings provide insights into the DNase involved in uniparental inheritance and its regulatory mechanism.2022年02月, Scientific reports, 12(1) (1), 2995 - 2995, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: This study aimed to identify prognostic factors for adenocarcinoma of the esophagogastric junction (AEG) in Siewert type II and characterize the population whose prognosis is expected to improve. PATIENTS AND METHODS: We retrospectively reviewed a database of 68 AEG type II patients who had undergone surgical curative resection without preoperative treatment. RESULTS: Although patients with pathological N0 (pN0) showed favorable 3-year disease-free survival (91%), patients with pN1-3 had poor outcomes (42%, 23%, and 10%). Multivariate analyses showed that the only independent prognostic factor was lymph node metastasis, and that tumor depth (cT3-4) and tumor size (≥4 cm) were correlated closely with lymph node metastasis. CONCLUSION: Surgical curative resection without preoperative treatment is insufficient to treat AEG type II with lymph node metastasis. Among AEG patients, those with the high-risk factors of preoperative tumor depth (T3-4) or/and size (≥4 cm) might need intensive multimodal treatment, including perioperative adjuvant chemotherapy.2022年02月, Anticancer research, 42(2) (2), 1051 - 1057, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: We conducted a prospective clinical control study to identify the best imaging technology among three-dimensional (3-D) high-definition (HD) stereovision and two-dimensional (2-D) ultra-high-resolution (4 K) technology and confirm their effects on surgical outcomes of laparoscopic gastrectomy for gastric cancer. METHODS: From April 2018 to August 2019, 50 patients were randomly classified into two groups based on the imaging technology (3-D/HD group = 25, 2-D/4 K = 25). After excluding eight patients based on laparoscopic findings, 42 patients were analyzed (3-D/HD group = 21, 2-D/4 K = 21). The primary endpoint was the operative time; the secondary endpoints were blood loss, postoperative infectious complications, and postoperative hospital stay. RESULTS: The patients' backgrounds were similar (sex, age, body mass index [BMI], stage, procedure, and extent of lymph node dissection). There were no significant differences in operative time (252 vs. 238 min, P = 0.70), total blood loss, postoperative infectious complications, and postoperative hospital stay between the two groups. However, video analysis of surgeries revealed a significantly shortened median operative time (18 vs. 25 min, P = 0.04) in the suturing step with 3-D/HD; the median number of camera cleaning procedures during suprapancreatic lymph node dissection was significantly lower with 2-D/4 K than with 3-D/HD (n = 4.4 vs. 2.8, P = 0.02). CONCLUSION: 3-D/HD and 2-D/4 K laparoscopic radical gastrectomies provide similar surgical outcomes. However, the 3-D monitor reduces suturing time during reconstruction, while the 4 K monitor reduces the number of camera cleaning procedures during lymphadenectomy. TRIAL REGISTRATION: Registered in the University Hospital Medical Information Network Clinical Trials Registry (identification number 000029227).2022年02月, Langenbeck's archives of surgery, 407(1) (1), 105 - 112, 英語, 国際誌研究論文（学術雑誌）
- 2022年01月, Annals of surgical oncology, 29(4) (4), 2672, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: The safety of gastrectomy for patients receiving antithrombotic agents remains unclear. This retrospective cohort study sought to compare outcomes between patients who did and did not receive antithrombotic agents. PATIENTS AND METHODS: This single-center retrospective cohort study included 548 patients who underwent gastrectomy for primary gastric adenocarcinoma from January 2011 to December 2019. The surgical outcomes were compared between two groups according to whether they received antithrombotic therapy (n=121) or not (n=427). RESULTS: Among the entire cohort, the patients in the antithrombotic therapy group were significantly older than those who did not receive this therapy and had significantly higher postoperative complication rates than those who did not (33.1% vs. 23.9%; p=0.046). However, after propensity score matching, no significant difference in the postoperative complication rate was observed between the two groups. CONCLUSION: Despite having a high risk for postoperative complications, patients receiving antithrombotic therapy can safely undergo gastric resection.2022年, Cancer diagnosis & prognosis, 2(2) (2), 210 - 215, 英語, 国際誌研究論文（学術雑誌）
- Situs inversus totalis (SIT) is a rare condition in which the internal organ's position is a mirror image of normal anatomy. Although several investigators reported laparoscopic surgery for colorectal cancer in patients with SIT, it is considered difficult even for an experienced surgeon because of the mirror position. We show a case report of laparoscopic sigmoidectomy with the splenic flexure mobilization (SFM) procedure in SIT. A 79-year-old woman with SIT was referred to our hospital for a locally advanced sigmoid cancer (cT3N1M0, cStageIIIB). We safely performed the laparoscopic sigmoidectomy with SFM, as shown in detail below. No postoperative complication occurred, and the patient is in good health with no recurrences 30 months after surgery, as of the writing this report. We propose three critical points; checking the CT angiography to understand the anatomy; using flip-horizontal video of "normal" laparoscopic sigmoidectomy to confirm an unfamiliar situation; adding the epigastric trocar to make SFM procedures safe and comfortable.2022年01月, Asian journal of endoscopic surgery, 15(1) (1), 168 - 171, 英語, 国内誌
- 2021年12月, Ann Surg Oncol, 28(Suppl 3) (Suppl 3), 455, 英語ASO Visual Abstract: IncidASO Visual Abstract: Incidence of Recurrent Laryngeal Nerve Palsy in Robot-Assisted Versus Conventional Minimally Invasive McKeown Esophagectomy in Prone Position: A Propensity Score-Matched Studyence of Recurrent Laryngeal Nerve Palsy in Robot-Assisted Versus Conventional Minimally Invasive McKeown Esophagectomy in Prone Position: A Propensity Score-Matched Study研究論文（学術雑誌）
- BACKGROUND: Despite the increasing utilization of transanal total mesorectal excision as a promising approach for low rectal cancer, the feasibility and safety of transperineal minimally invasive abdominoperineal resection (tp-APR) remain unclear. METHODS: In total, 25 patients who underwent tp-APR between April 2017 and May 2020 (tp-APR group) and 27 patients who underwent conventional laparoscopic APR between May 2009 and September 2016 (lap-APR group) for low rectal cancer were enrolled in this retrospective study. Clinical outcomes were compared between the groups before and after propensity score matching. The primary outcome was the incidence of the overall postoperative complications with Clavien-Dindo grade II or above. Standardized technique of tp-APR was also demonstrated. RESULTS: On comparison, operative time, intraoperative blood loss, and overall postoperative complications with Clavien-Dindo grade II or above were significantly less in the tp-APR group both before and after propensity score matching. The rates of urinary disturbance and perineal wound infection were significantly less in the tp-APR group after matching. Further, postoperative hospital stay was significantly shorter in the tp-APR group both before and after matching. However, pathological outcomes did not differ between the groups before and after matching. There has been no local recurrence in the tp-APR group with a median follow-up period of 18 months. CONCLUSION: Standardized tp-APR for low rectal cancer is feasible and seems superior to conventional laparoscopic APR in terms of short-term outcomes. Further larger-scale studies with a longer follow-up period are required to evaluate oncological outcomes.2021年12月, Surgical endoscopy, 35(12) (12), 7236 - 7245, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: One of the primary treatment for resectable advanced esophageal squamous cell cancer (ESCC) is neoadjuvant chemotherapy (NAC) followed by minimally invasive esophagectomy (MIE). Because the neutrophil-to-lymphocyte ratio (NLR) is a widely reported prognostic factor in several cancers, we investigated whether the preoperative NLR is a biomarker in ESCC patients treated with NAC and MIE. METHODS: In this study, we investigated 174 ESCC patients who underwent MIE from January 2010 to December 2015, including 121 patients who received NAC. The cutoff value of the NLR was analyzed using the receiver operating characteristic curve. Multivariate analyses were performed to clarify independent prognostic factors for overall survival (OS). RESULTS: The cutoff value of the NLR for OS in 121 patients who received NAC was 2.5 ng/ml, and the area under the curve was 0.63026 (p = 0.0127). The 5-year OS rate was 64% in those with an NLR <2.5 and 39% in those with an NLR ≥2.5. According to multivariate analysis, NLR ≥2.5, pathological T, pathological N, and intraoperative blood loss of >415 ml were independent poor prognostic factors. CONCLUSIONS: NLR is a biomarker of prognosis in ESCC patients who undergo MIE after NAC.2021年12月, Journal of surgical oncology, 124(7) (7), 1022 - 1030, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Although lateral pelvic lymph node dissection is considered as a treatment option for advanced rectal cancer, it is technically demanding. Recently, the transanal approach for total mesorectal excision has become increasingly used. In this Technical Note, we describe lateral pelvic lymph node dissection using a 2-team method that was assisted by the transanal approach. TECHNIQUE: First, the lateral pelvic area was entered from the anal side by dissection between the S4 sacral splanchnic nerve and levator ani muscle. Then, the fatty tissues including the obturator compartment and the distal part of the internal iliac compartment were separated from the inferior and superior vesical vessels and the bladder wall. Next, the fatty tissues were separated from the lateral pelvic wall. The obturator nerve was isolated and preserved, whereas the obturator vessels were resected at their peripheral end. Then, the fatty tissues were dissected from the bottom plane. Finally, the fatty tissues were dissected from the ventral bladder wall and were completely isolated from the obturator nerve in cooperation with the transabdominal team. RESULTS: The 2-team method shortened the operative time dramatically and decreased mental and physical burden on the operators during lateral dissection. Assistance with the transanal approach helped with a secure and effective dissection, especially of the most distal parts, such as around the internal pudendal and inferior vesical arteries, because substantial skill is required for the transabdominal approach alone. CONCLUSIONS: This procedure is useful for the safe and effective performance of lateral pelvic lymph node dissection for patients with rectal cancer.2021年12月, Diseases of the colon and rectum, 64(12) (12), e719-e724, 英語, 国際誌研究論文（学術雑誌）
- 2021年11月, Annals of surgical oncology, 28(12) (12), 7258 - 7258, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Esophagectomy with lymphadenectomy is the principal treatment for localized esophageal cancer. Conventional minimally invasive esophagectomy (C-MIE) in prone position has spread worldwide as it is less invasive. However, its efficacy remains controversial. Robot-assisted MIE (RAMIE) can have more advantages than C-MIE. Therefore, the current study aimed to validate whether RAMIE is associated with lower incidence of left recurrent laryngeal nerve (RLN) palsy compared with C-MIE in prone position. PATIENTS AND METHODS: In total, 404 patients with esophageal carcinoma underwent MIE (353 C-MIEs and 51 RAMIEs) in prone position at Kobe University between 2010 and 2020. Then, propensity score matching was performed, and results showed that 51 patients should be included in each group. Thereafter, the perioperative outcomes between the two groups were compared. RESULTS: The RAMIE group had a significantly longer operative time than the C-MIE group (P < 0.0001). However, the number of lymph nodes resected along the left RLN was similar in both groups. Moreover, the incidence of left RLN palsy was significantly lower in the RAMIE group than in the C-MIE [Clavien-Dindo classification grade II; 0 (0%) versus 32 (9%), P = 0.022 in entire cohort, and 0 (0%) versus 5 (10%), P = 0.022 in matched cohort. Esophagectomy Complications Consensus Group definitions type I; 8 (16%) versus 101 (29%), P = 0.041 in entire cohort and 8 (16%) versus 18 (35%) in matched cohort, P = 0.023]. CONCLUSION: RAMIE is superior to C-MIE in prone position in decreasing the incidence of left RLN palsy.2021年11月, Annals of surgical oncology, 28(12) (12), 7249 - 7257, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: There has been an increase in the percentage of elderly patients with colorectal cancer (CRC). However, few studies have reported the short- and long-term outcomes of laparoscopic surgery for elderly patients with CRC aged over 80 years. METHODS: This study included 529 patients who underwent laparoscopic resection for clinical stage 0-III CRC at Kobe University Hospital between January 2010 and December 2018. Propensity score matching (PSM) was used to create balanced cohorts of the elderly (aged ≥ 80, n = 113) and the non-elderly (aged < 80, n = 113). Their clinical outcomes were compared after PSM. RESULTS: After matching, carcinoembryonic antigen (CEA) level was higher in the non-elderly group, and adjuvant chemotherapy was less frequently employed in the elderly group. D3 dissection was performed more frequently and the number of the harvested lymph nodes tended to be larger in the non-elderly group. There was no significant difference in the rates of postoperative complications, reoperation within 30 days, and 30-day mortality between the groups. The 5-year relapse-free survival rate was not statistically different between the two groups (77.3% for the non-elderly vs. 62.7% for the elderly, p = 0.13). The multivariate analyses for the whole cohort showed that the factors of sex, tumor location, operation time, and conversion to open surgery, but not the age, were significant predictors of postoperative complications. CONCLUSION: Laparoscopic surgery for colorectal cancer patients aged over 80 years is technically and oncologically safe.2021年11月, International journal of colorectal disease, 36(11) (11), 2519 - 2528, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Lateral pelvic lymph node metastasis impairs the oncological outcomes of patients with rectal cancer. Although lateral pelvic lymph node dissection (LLND) might be an effective procedure for such patients, the associated risk factors for postoperative complications are unknown. PATIENTS AND METHODS: The operative outcomes of 21 patients undergoing unilateral LLND and 26 patients undergoing bilateral LLND for rectal cancer were compared. The risk factors for complications were evaluated using a logistic regression model. RESULTS: Univariate and multivariate analyses revealed that a longer operative time (≥480 min) was the most important risk factor for grade II or more postoperative complications according to the Clavien-Dindo classification (odds ratio=6.58; 95% confidence interval=1.35-32.1; p=0.020). A bilateral procedure was not a significant risk factor for postoperative complications. CONCLUSION: Surgeons should make efforts to shorten the operative time to reduce the risk of postoperative complications.2021年11月, Anticancer research, 41(11) (11), 5599 - 5604, 英語, 国際誌研究論文（学術雑誌）
- (株)医学書院, 2021年10月, 臨床外科, 76(10) (10), 1271 - 1280, 日本語
- Springer Science and Business Media LLC, 2021年10月, Annals of surgical oncology, 28(11) (11), 6339 - 6340, 英語, 国際誌研究論文（学術雑誌）
- 金原出版(株), 2021年10月, 手術, 75(11) (11), 1673 - 1677, 日本語
- BACKGROUND: Given the worldwide popularization of conventional minimally invasive esophagectomy (C-MIE), robot-assisted MIE (RAMIE) can be expected to provide a finer procedure. However, controversy remains regarding whether RAMIE is superior to C-MIE in preventing recurrent laryngeal nerve (RLN) palsy. Considering the shallow learning curve for RAMIE, a novel procedure for lymphadenectomy along the RLN during RAMIE is needed. METHODS: Based on a logical and simple understanding of the left upper mediastinum anatomy, the authors developed a novel "modified bascule method" for RAMIE that could simplify lymphadenectomy along the left RLN and prevent it from being touched and stretched. Between 2018 and 2020, 46 patients with esophageal carcinoma underwent RAMIE using this method at Kobe University. RESULTS: The modified bascule method was used to perform RAMIE for 29 men and 17 women with a median age of 67 years (range, 49-82 years). The median thoracoscopic procedure time was 438 min (range, 344-625 min), and the median console time was 351 min (range 273-518 min). The study harvested a median of 24 (range, 8-34) lymph nodes from the thoracic portion and 4 (range, 0-10) lymph nodes from along the left RLN. The mortality rate was 0%. Postoperative left RLN palsy classified as Clavien-Dindo (C-D) grade 1 or higher was observed for 9 patients (19%), whereas grade 2 or higher was not seen (0%). Pneumonia and anastomotic leakage rates higher than C-D grade 2 were respectively 13% and 19%. CONCLUSIONS: The novel modified bascule method for RAMIE can promote feasible lymphadenectomy along the left RLN even when performed during the learning period.2021年09月, Annals of surgical oncology, 28(9) (9), 4918 - 4927, 英語, 国際誌研究論文（学術雑誌）
- 金原出版(株), 2021年09月, 手術, 75(10) (10), 1519 - 1524, 日本語
- (株)自然科学社, 2021年09月, 医学と薬学, 78(10) (10), 1167 - 1173, 日本語
- BACKGROUND: Esophageal squamous cell cancer (ESCC) is one of the deadliest cancers in the world. Esophagectomy remains the principal treatment, and minimally invasive esophagectomy (MIE) has been performed worldwide. This study aimed to clarify whether the lymph node ratio (LNR), defined as the ratio of metastatic lymph nodes (LNs) to examined, is a prognostic factor for ESCC after MIE. METHODS: This study included 327 MIEs with the patient in the prone position at two institutions from 2010 to 2015. Cox proportional hazards regression analyses using clinicopathologic characteristics and the LNR were performed for the pN1 patients and the whole cohort. RESULTS: In the multivariate analysis for all stages, independent prognostic factors were depth of tumor invasion (P < 0.0001), LNR (P = 0.014), operative time (P = 0.003), and pneumonia (P = 0.012). In the analysis of the pN1 subgroup, the optimum LNR cutoff level for overall survival (OS) was 9 based on receiver operation characteristic analysis. The LNR was significantly associated with depth of tumor invasion (P = 0.004) and number of metastatic LNs (P < 0.0001). The OS curve for the group with an LNR of 9 or higher was significantly worse than for the group with an LNR lower than 9 (P < 0.001). Multivariate analyses demonstrated that the LNR is a unique independent prognostic factor for the pN1 subgroup (hazard ratio, 6.811; 95% confidence interval, 2.009-23.087; P = 0.002). CONCLUSIONS: The LNR is an independent prognostic factor in ESCC after MIE. Especially for patients with pN1 status, the LNR is more useful than the number of metastatic LNs for predicting survival outcome.2021年08月, Annals of surgical oncology, 28(8) (8), 4519 - 4528, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Cancer stem cells (CSCs) contribute to resistance against neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC). We conducted a retrospective observational study for the relationship between the expression levels of CSC markers in biopsy specimens prior to 5-fluorouracil plus cisplatin (FP)-NAC and the pathological responses. PATIENTS AND METHODS: We included 171 patients with ESCC who underwent the FP-NAC followed by radical resection. Biopsy specimens prior to the FP-NAC were obtained and immunochemically stained for CD44, CD133, and CD24. RESULTS: The biopsy specimens of the non-responders had the CD44high/CD24low expression at high levels, which was found as an independent predictor of not only FP-NAC resistance but also poor overall survival by multivariate analyses. CONCLUSION: CD44high/CD24low expression in the biopsy specimens prior to FP-NAC may be a predictor of FP-NAC resistance and poor prognosis of ESCC patients.2021年08月, Anticancer research, 41(8) (8), 4117 - 4126, 英語, 国際誌研究論文（学術雑誌）
- Aim: The outcomes of gastrectomy for gastric cancer in patients at each severity of chronic kidney disease (CKD) remain unknown. Methods: We retrospectively analyzed the outcomes of 560 patients who underwent distal or total gastrectomy for gastric cancer between 2009 and 2018. We classified the patients into four groups based on estimated glomerular filtration rate: stage 1/2 (normal to mild, n = 375), stage 3a (mild to moderate, n = 122), stage 3b (moderate to severe, n = 43), and stage 4/5 (severe to end-stage, n = 20) CKD. The relationship between CKD stage and the incidence of postoperative morbidity was analyzed. Results: CKD was a predictor of overall morbidity independent of age, gender, American Society of Anesthesiologists Performance Status, pulmonary comorbidity, extent of lymphadenectomy, and operation time in a multivariate analysis. The incidences of overall and severe morbidity were significantly increased with CKD progression (both P < .001). Compared to stage 1/2 CKD, the odds of overall morbidity were significantly elevated in stage 3a (odds ratio [OR] 1.87, P = .007), stage 3b (OR 3.86, P < .001), and stage 4/5 (OR 8.60, P < .001). The risk of procedure-related morbidity was strikingly increased in stage 3b (OR 2.93, P = .004). The risk of procedure-unrelated morbidity elevated markedly in stage 3a (OR 2.77, P = .001). A significant graded association between CKD progression and overall morbidity was also revealed in elderly patients (P = .001). Conclusions: The severity of CKD predicts the likelihood and type of morbidity after gastrectomy and can guide surgical decision-making for patients with gastric cancer.2021年07月, Annals of gastroenterological surgery, 5(4) (4), 519 - 527, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: Minimally invasive esophagectomy (MIE) has been increasingly used, but many reports have stated that recurrent laryngeal nerve (RLN) palsy after MIE is a major complication associated with postoperative pneumonia. Prevention of RLN palsy clearly has been a challenging task. The study aim was to determine if a three-dimensional (3-D) stereoscopic vision system can reduce the RLN palsy rate after MIE. METHODS: This was a retrospective study of MIE (McKeown esophagectomy) using a 3-D or 2-D stereoscopic vision system to treat 358 patients in the prone position between April 2010 and March 2019. The patients who underwent 3-D MIE (3-D group) or 2-D MIE (2-D group) were matched by using propensity score matching. After matching, the perioperative outcomes were compared between the groups. RESULTS: After propensity score matching, 154 patients were analyzed (77 patients, 3-D group; 77 patients, 2-D group). There were no significant differences in the patients' baseline characteristics in the matched cohort. There were no significant differences in the rates of pneumonia (Clavien-Dindo (C-D) grade ≥ II, 3-D vs. 2-D, 11 (14%) vs. 12 (16%)), anastomotic leakage (C-D grade ≥ II, 10 (13%) vs. 18 (23%)) and mortality. The rates of left RLN palsy (C-D grade ≥ IIIa, 1 (1.3%) vs. 7 (9.1%), P = 0.029), right RLN palsy (C-D grade ≥ I, 2 (3%) vs. 8 (10%), P = 0.049), comprehensive complication index (CCI®) (8.5 vs. 14.3, P = 0.011), and postoperative hospital stay period (median: 25 vs. 30 days, P = 0.034) were significantly lower in the 3-D group than in the 2-D group, respectively. CONCLUSIONS: In MIE, the 3-D viewing system was one of the factors that reduced postoperative morbidities such as the rates of each RLN palsy and CCI®, leading to shorter postoperative hospital stay.2021年05月, Langenbeck's archives of surgery, 406(3) (3), 631 - 639, 英語, 国際誌研究論文（学術雑誌）
- (株)へるす出版, 2021年05月, 消化器外科, 44(6) (6), 705 - 708, 日本語【消化器癌;診断と治療のすべて】消化器癌の診断・病期分類・治療・成績 胃癌 集学的治療
- Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon is unclear. cDNA microarray analysis indicates that the expression of chemokine (C-C motif) ligand 1 (CCL1) is up-regulated in peripheral blood monocyte-derived macrophages stimulated using conditioned media from ESCC cells (TAM-like macrophages). Here, we evaluated the role of CCL1 in ESCC progression. CCL1 was overexpressed in TAM-like macrophages, and CCR8, a CCL1 receptor, was expressed on ESCC cell surface. TAM-like macrophages significantly enhanced the motility of ESCC cells, and neutralizing antibodies against CCL1 or CCR8 suppressed this increased motility. Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa/mammalian target of rapamycin pathway. Phosphatidylinositol 3-kinase or Akt inhibitors, CCR8 silencing, and neutralizing antibody against CCR8 could significantly suppress these effects. The overexpression of CCL1 in stromal cells or CCR8 in ESCC cells was significantly associated with poor overall survival (P = 0.002 or P = 0.009, respectively) and disease-free survival (P = 0.009 or P = 0.047, respectively) in patients with ESCC. These results indicate that the interaction between stromal CCL1 and CCR8 on cancer cells promotes ESCC progression via the Akt/proline-rich Akt substrate of 40 kDa/mammalian target of rapamycin pathway, thereby providing novel therapeutic targets.2021年04月, The American journal of pathology, 191(4) (4), 686 - 703, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Given the worldwide popularization of conventional minimally invasive esophagectomy (C-MIE), robot-assisted MIE (RAMIE) can be expected to provide a finer procedure. However, controversy remains regarding whether RAMIE is superior to C-MIE in preventing recurrent laryngeal nerve (RLN) palsy. Considering the shallow learning curve for RAMIE, a novel procedure for lymphadenectomy along the RLN during RAMIE is needed. METHODS: Based on a logical and simple understanding of the left upper mediastinum anatomy, the authors developed a novel "modified bascule method" for RAMIE that could simplify lymphadenectomy along the left RLN and prevent it from being touched and stretched. Between 2018 and 2020, 46 patients with esophageal carcinoma underwent RAMIE using this method at Kobe University. RESULTS: The modified bascule method was used to perform RAMIE for 29 men and 17 women with a median age of 67 years (range, 49-82 years). The median thoracoscopic procedure time was 438 min (range, 344-625 min), and the median console time was 351 min (range 273-518 min). The study harvested a median of 24 (range, 8-34) lymph nodes from the thoracic portion and 4 (range, 0-10) lymph nodes from along the left RLN. The mortality rate was 0%. Postoperative left RLN palsy classified as Clavien-Dindo (C-D) grade 1 or higher was observed for 9 patients (19%), whereas grade 2 or higher was not seen (0%). Pneumonia and anastomotic leakage rates higher than C-D grade 2 were respectively 13% and 19%. CONCLUSIONS: The novel modified bascule method for RAMIE can promote feasible lymphadenectomy along the left RLN even when performed during the learning period.2021年03月, Annals of surgical oncology, 28(9) (9), 4918 - 4927, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: Laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS) has been developed to prevent duodenal leakage by reinforcing the endoscopic submucosal dissection site. However, there has been no prospective trial showing the feasibility of D-LECS. Herein, we conducted a single-arm confirmatory trial to evaluate the safety of D-LECS for non-ampullary superficial duodenal neoplasms. METHODS: This prospective single-center single-arm confirmatory trial analyzed patients with non-ampullary superficial duodenal neoplasms who underwent D-LECS. The primary endpoint was the incidence of any postoperative leakage occurring on the duodenal wall within 1 month postoperatively. The planned sample size was 20 patients, considering a threshold of 28% and one-sided alpha value of 5%. RESULTS: Between January 2015 and September 2018, 20 eligible patients were enrolled. Sixteen tumors were located in the second portion, three in the first portion, and one in the third portion of the duodenal region. The median operative time was 225 (134-361) min and the median blood loss was 0 (0-150) mL. Curative resection (R0) with negative margins was achieved in 19 cases. One case of postoperative leakage and one case of bleeding of grade 2 according to the Clavien-Dindo classification were observed in this series. The median duration of postoperative hospital stay was 9 (5-12) days. No local recurrence was observed in any patient during the median follow-up of 15.0 (12.0-38.0) months. CONCLUSIONS: This trial confirmed the safety and feasibility of D-LECS for non-ampullary superficial duodenal neoplasms with respect to the low incidence of postoperative duodenal leakage.2021年03月, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33(3) (3), 373 - 380, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: The safety of neoadjuvant chemoradiotherapy (NACRT) combined with total mesorectal excision (TME) and selective lateral pelvic lymph node dissection (LLND) is unclear in elderly patients with locally advanced rectal cancer (LARC). PATIENTS AND METHODS: Forty-two patients with LARC underwent TME and selective LLND following NACRT at Kobe University Hospital. The clinical outcomes were retrospectively compared between the elderly (aged ≥70 years, n=13) and non-elderly patients (aged <70, n=29). RESULTS: Twelve of the thirteen elderly patients could complete NACRT. Although the overall rate of postoperative complications did not differ between the groups, abdominal wound infection and deep vein thrombosis developed more frequently in the elderly group. The length of the postoperative hospital stay was similar. Three-year overall survival and 3-year relapse-free survival rates were similar between the groups. CONCLUSION: Selective LLND after NACRT is safe for elderly patients with LARC.2021年03月, Anticancer research, 41(3) (3), 1677 - 1682, 英語, 国際誌研究論文（学術雑誌）
- Tumor-associated macrophages (TAMs) promote tumor progression. The number of infiltrating TAMs is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC) patients; however, the mechanism underlying this phenomenon is unclear. Our previous cDNA microarray analysis had revealed that the expression of C-C motif chemokine ligand 1 (CCL1) is upregulated in peripheral blood monocyte (PBMo)-derived macrophages stimulated using conditioned media from ESCC cells (TAM-like macrophages). In this study, we evaluated the role of CCL1 in ESCC progression. We confirmed that CCL1 is overexpressed in TAM-like macrophages, and that C-C motif chemokine receptor 8 (CCR8), a CCL1 receptor, is expressed on ESCC cell surface. TAM-like macrophages significantly enhanced the motility of ESCC cells, and neutralizing antibodies against CCL1 or CCR8 suppressed this increased motility. Recombinant human CCL1 promoted ESCC cell motility via the Akt/proline-rich Akt substrate of 40 kDa (PRAS40)/mammalian target of rapamycin (mTOR) pathway. PI3K or Akt inhibitors, CCR8 silencing, and neutralizing antibody against CCR8 could significantly suppress these effects. The overexpression of CCL1 in stromal cells or CCR8 in ESCC cells was significantly associated with poor overall survival (P = 0.002 or 0.009) and disease-free survival (P = 0.009 or 0.047) in ESCC patients. These results indicated that the interaction between stromal CCL1 and CCR8 on cancer cells promotes ESCC progression via the Akt/PRAS40/mTOR pathway, providing novel therapeutic targets.2021年01月, The American journal of pathology, 191(4) (4), 686 - 703, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Esophageal squamous cell cancer (ESCC) is one of the deadliest cancers in the world. Esophagectomy remains the principal treatment, and minimally invasive esophagectomy (MIE) has been performed worldwide. This study aimed to clarify whether the lymph node ratio (LNR), defined as the ratio of metastatic lymph nodes (LNs) to examined, is a prognostic factor for ESCC after MIE. METHODS: This study included 327 MIEs with the patient in the prone position at two institutions from 2010 to 2015. Cox proportional hazards regression analyses using clinicopathologic characteristics and the LNR were performed for the pN1 patients and the whole cohort. RESULTS: In the multivariate analysis for all stages, independent prognostic factors were depth of tumor invasion (P < 0.0001), LNR (P = 0.014), operative time (P = 0.003), and pneumonia (P = 0.012). In the analysis of the pN1 subgroup, the optimum LNR cutoff level for overall survival (OS) was 9 based on receiver operation characteristic analysis. The LNR was significantly associated with depth of tumor invasion (P = 0.004) and number of metastatic LNs (P < 0.0001). The OS curve for the group with an LNR of 9 or higher was significantly worse than for the group with an LNR lower than 9 (P < 0.001). Multivariate analyses demonstrated that the LNR is a unique independent prognostic factor for the pN1 subgroup (hazard ratio, 6.811; 95% confidence interval, 2.009-23.087; P = 0.002). CONCLUSIONS: The LNR is an independent prognostic factor in ESCC after MIE. Especially for patients with pN1 status, the LNR is more useful than the number of metastatic LNs for predicting survival outcome.2021年01月, Annals of surgical oncology, 28(8) (8), 4519 - 4528, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND/AIM: Adenocarcinoma of the esophagogastric junction (AEG) is refractory even when curative resection is followed by adjuvant chemotherapy. This study evaluated the efficacy of neoadjuvant chemotherapy (NAC) using an oral fluoropyrimidine-platinum regimen for AEG. PATIENTS AND METHODS: Out of 35 patients with locally advanced AEG who underwent curative resection, 21 who underwent surgery first and 14 who received NAC were retrospectively compared in terms of survival. RESULTS: The NAC regimens comprised of S-1 or capecitabine plus oxaliplatin or cisplatin; trastuzumab was added to six borderline resectable cases. The downstaging rate was 50% and the pathological response rate including complete response (29%) was 50%. The three-year relapse-free survival in the NAC group was significantly superior than the surgery-first group (78% vs. 22%, p=0.011). The NAC group had a significantly longer median survival time than the surgery-first group (NR vs. 29 months, p=0.032). CONCLUSION: NAC using an oral fluoropyrimidine-platinum regimen may provide survival benefit in AEG.2021年, Cancer diagnosis & prognosis, 1(3) (3), 185 - 191, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study was conducted to determine whether establishing the proximal resection line using India ink tattooing can ensure safe resection margins during totally laparoscopic distal gastrectomy. METHODS: This retrospective study included 81 patients who underwent totally laparoscopic distal gastrectomy for gastric cancer on the lower two-thirds of the stomach. The proximal resection margins were analyzed with respect to the macroscopic type and clinical T stage, and the intraoperative appearance of the stain on the serosa was classified by reviewing surgical videos. RESULTS: R0 resection was performed in all patients. The rates of the intended margins were 89.2% in patients without a frozen section diagnosis and 84.2% in patients with differentiated type lesions who underwent a frozen section diagnosis; however, most patients with undifferentiated advanced lesions failed to achieve the intended resection margins. Intraoperative appearance revealed that 85.2% of patients had localized type stains, whereas 11.1% had widespread-type stains. CONCLUSIONS: Our procedure to determine the proximal resection line in totally laparoscopic distal gastrectomy is oncologically safe. However, careful observation of the resected specimen and a frozen section analysis should be performed for undifferentiated advanced lesions.2021年01月, Surgery today, 51(1) (1), 111 - 117, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Patients often experience severe weight loss after oesophagectomy. Enteral nutrition via a feeding jejunostomy tube (FT) is commonly practised. This study aimed to assess the effect of severe weight loss postoperatively and enteral nutrition via an FT on long-term prognosis after oesophagectomy. METHODS: This study analysed 317 patients who underwent minimally invasive oesophagectomy at Kobe University Hospital and Hyogo Cancer Center from 2010 to 2015. The patients' body weight was evaluated at 3 months postoperatively. They were organised into the severe weight loss (n = 65) and moderate weight loss (n = 252) groups. Furthermore, they were categorised into the FT group (184 patients who had an FT placed during oesophagectomy) and no-FT group (133 patients without FT). Patients (119 per group) matched for the FT and no-FT groups were identified via propensity score matching. RESULTS: The 5-year overall survival (OS) rate in the severe weight loss group was significantly lower (p = 0.024). In the multivariate analysis, tumour invasion depth (pT3-4), preoperative therapy and severe weight loss had a worse OS (hazard ratio = 1.89; 95% confidence interval = 1.12-3.17, hazard ratio = 2.11; 95% confidence interval = 1.25-3.54, hazard ratio = 1.82; 95% confidence interval = 1.02-3.524, respectively). No significant differences in the number of severe weight loss patients and OS were found between the FT and no-FT groups. CONCLUSION: Severe weight loss is significantly associated with poor OS. In addition, enteral nutrition via an FT did not improve the severe weight loss and OS.2020年12月, BMC gastroenterology, 20(1) (1), 407 - 407, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Minimally invasive esophagectomy (MIE) has been increasingly used, but many reports have stated that recurrent laryngeal nerve (RLN) palsy after MIE is a major complication associated with postoperative pneumonia. Prevention of RLN palsy clearly has been a challenging task. The study aim was to determine if a three-dimensional (3-D) stereoscopic vision system can reduce the RLN palsy rate after MIE. METHODS: This was a retrospective study of MIE (McKeown esophagectomy) using a 3-D or 2-D stereoscopic vision system to treat 358 patients in the prone position between April 2010 and March 2019. The patients who underwent 3-D MIE (3-D group) or 2-D MIE (2-D group) were matched by using propensity score matching. After matching, the perioperative outcomes were compared between the groups. RESULTS: After propensity score matching, 154 patients were analyzed (77 patients, 3-D group; 77 patients, 2-D group). There were no significant differences in the patients' baseline characteristics in the matched cohort. There were no significant differences in the rates of pneumonia (Clavien-Dindo (C-D) grade ≥ II, 3-D vs. 2-D, 11 (14%) vs. 12 (16%)), anastomotic leakage (C-D grade ≥ II, 10 (13%) vs. 18 (23%)) and mortality. The rates of left RLN palsy (C-D grade ≥ IIIa, 1 (1.3%) vs. 7 (9.1%), P = 0.029), right RLN palsy (C-D grade ≥ I, 2 (3%) vs. 8 (10%), P = 0.049), comprehensive complication index (CCI®) (8.5 vs. 14.3, P = 0.011), and postoperative hospital stay period (median: 25 vs. 30 days, P = 0.034) were significantly lower in the 3-D group than in the 2-D group, respectively. CONCLUSIONS: In MIE, the 3-D viewing system was one of the factors that reduced postoperative morbidities such as the rates of each RLN palsy and CCI®, leading to shorter postoperative hospital stay.2020年11月, Langenbeck's archives of surgery, 406(3) (3), 631 - 639, 英語, 国際誌研究論文（学術雑誌）
- The number of elderly patients with esophageal cancer has increased in recent years. The use of thoracoscopic esophagectomy has also increased, and its minimal invasiveness is believed to contribute to postoperative outcomes. However, the short- and long-term outcomes in elderly patients remain unclear. This study aimed to elucidate the safety and feasibility of minimally invasive esophagectomy in elderly patients. This retrospective study included 207 patients who underwent radical thoracoscopic esophagectomy for thoracic esophageal squamous cell carcinoma at Kobe University Hospital between 2005 and 2014. Patients were divided into non-elderly (<75 years) and elderly (≥75 years) groups. A propensity score matching analysis was performed for sex and clinical T and N stage, with a total of 29 matched pairs. General preoperative data, surgical procedures, intraoperative data, postoperative complications, in-hospital death, cancer-specific survival, and overall survival were compared between groups. The elderly group was characterized by lower preoperative serum albumin levels and higher American Society of Anesthesiologists grade. Intraoperative data and postoperative complications did not differ between the groups. The in-hospital death rate was 4% in the elderly group, which did not significantly differ from the non-elderly group. Cancer-specific survival was similar between the two groups. Although overall survival tended to be poor in the elderly group, it was not significantly worse than that of the non-elderly group. In conclusion, the short- and long-term outcomes of minimally invasive esophagectomy in elderly versus non-elderly patients were acceptable. Minimally invasive esophagectomy is a safe and feasible modality for elderly patients with appropriate indications.Oxford University Press (OUP), 2020年09月, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 34(3) (3), 英語, 国際誌研究論文（学術雑誌）
- Tumor-associated macrophages (TAMs) contribute to the progression and mortality of various malignancies. We reported that high numbers of infiltrating TAMs were significantly associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma (ESCC). In our previous investigation of TAMs' actions in ESCC, we compared gene expression profiles between peripheral blood monocyte (PBMo)-derived macrophages and TAM-like macrophages stimulated with conditioned media of ESCC cell lines. Among the upregulated genes in the TAM-like macrophages, we focused on CC chemokine ligand 3 (CCL3), which was reported to contribute to tumor progression in several malignancies. Herein, we observed that not only TAMs but also ESCC cell lines expressed CCL3. A CCL3 receptor, CC chemokine receptor 5 (CCR5) was expressed in the ESCC cell lines. Treating the ESCC cell lines with recombinant human (rh)CCL3 induced the phosphorylations of Akt and ERK, which were suppressed by CCR5 knockdown. Migration and invasion of ESCC cells were promoted by treatment with rhCCL3 and co-culture with TAMs. TAMs/rhCCL3-promoted cell migration and invasion were suppressed by inhibition of the CCL3-CCR5 axis, PI3K/Akt, and MEK/ERK pathways. Treatment with rhCCL3 upregulated MMP2 and VEGFA expressions in ESCC cell lines. Our immunohistochemical analysis of 68 resected ESCC cases showed that high expression of CCL3 and/or CCR5 in ESCC tissues was associated with poor prognosis. High CCR5 expression was associated with deeper invasion, presence of vascular invasion, higher pathological stage, higher numbers of infiltrating CD204+ TAMs, and higher microvascular density. High expression of both CCL3 and CCR5 was an independent prognostic factor for disease-free survival. These results suggest that CCL3 derived from both TAMs and cancer cells contributes to the progression and poor prognosis of ESCC by promoting cell migration and invasion via the binding of CCR5 and the phosphorylations of Akt and ERK. The CCL3-CCR5 axis could become the target of new therapies against ESCC.Springer Science and Business Media LLC, 2020年09月, Laboratory investigation; a journal of technical methods and pathology, 100(9) (9), 1140 - 1157, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- INTRODUCTION: Three-dimensional (3D) laparoscopic vision can improve depth perception. However, it is a question whether 3D vision can improve motion in the depth direction. The aim of this study was to compare the impact of 3D vision on forceps motion in the depth and horizontal directions. METHODS: All data were obtained from our previous two studies, where, in total, 40 novices and 20 moderately experienced surgeons participated. A simple phantom task was performed in a training box. The participants were randomly assigned to two groups. Specifically, one group performed the task five times initially under a two-dimensional (2D) system, and the other group started under a 3D system. Both groups then performed the same task five times under the alternative system. Performances were recorded by an optical position tracker. We separately evaluated forceps motion in the x-, y-, and z-axis directions. RESULTS: Compared with the findings for 2D vision, the forceps path lengths were significantly decreased among novices and moderately experienced surgeons in almost all tasks under 3D vision. In a comparison of the path length ratio (3D/2D) in each direction, larger reduction was observed for the depth direction among novices, whereas no significant directional difference was noted among moderately experienced surgeons. CONCLUSIONS: For novices, 3D laparoscopic vision improves depth perception and may give shorter forceps movement in the depth direction even for simple tasks.2020年07月, Asian journal of endoscopic surgery, 13(3) (3), 265 - 271, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- PURPOSE: Skeletal muscle loss after gastrectomy can worsen patients' quality of life and prognosis. Laparoscopic gastrectomy is less invasive than open gastrectomy and has become commonly performed. However, the degree of skeletal muscle loss after laparoscopic procedures remains unclear. We herein report the degree and risk factors of psoas muscle loss after laparoscopic gastrectomy for gastric cancer. METHODS: The total psoas area (TPA) on computed tomography of 50 consecutive patients who underwent laparoscopic total gastrectomy (LTG) and 167 consecutive patients who underwent laparoscopic distal gastrectomy (LDG) for gastric cancer was retrospectively evaluated at one postoperative year. The TPA loss was compared between LDG and LTG and univariate and multivariate analyses were performed to identify the risk factors for TPA loss > 10%. RESULTS: The median TPA decrease rate was 5.9% in the LDG group and 15.6% in the LTG group. LTG and postoperative respiratory complications were independent factors associated with a severe TPA loss of > 10%. In the LTG group, no independent factors were identified in a multivariate analysis. In the LDG group, postoperative complications were identified as an independent risk factor for TPA loss > 10%. CONCLUSIONS: Laparoscopic gastrectomy leads to postoperative TPA loss, especially in patients who underwent LTG and had postoperative respiratory complications. Postoperative complications after LDG were also a risk factor for TPA loss.2020年07月, Surgery today, 50(7) (7), 693 - 702, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: We report a rare case of gastrointestinal stromal tumors (GISTs) in Carney's triad, successfully treated using laparoscopic gastrectomy with lymph node dissection after chemotherapy. CASE PRESENTATION: A 21-year-old woman presented to our hospital for treatment of recurrent GISTs. The patient had been admitted for treatment 11 years prior, with black stools being the chief presenting complaint at that time. On examination at that time, multiple submucosal tumors in the pyloric antrum and multiple pulmonary tumors had been observed. She underwent open partial gastrectomy, and the diagnosis of GISTs was confirmed. She was administered tyrosine kinase inhibitors to treat lung metastases from 2 months after surgery. Due to the increasing size of the lung tumors, a right upper lobectomy was performed 9 years after the index gastric surgery. Histopathological examination of the lung specimen, in combination with re-examination of the gastric specimens, was indicative of incomplete-type Carney's triad. Eleven years after the index gastric surgery, multiple GISTs were observed in her entire stomach. Tumor biopsy revealed a succinate dehydrogenase deficiency, confirming the diagnosis of recurrent GISTs. For treatment, the patient underwent laparoscopic completion gastrectomy, with D1 plus lymph node dissection. CONCLUSION: This is a first case report of completion gastrectomy performed laparoscopically for the treatment of GISTs associated with incomplete-type Carney's triad. The recurrent GISTs developed over a protracted period of 11 years from the index gastric surgery to tumor recurrence.2020年05月, Surgical case reports, 6(1) (1), 112 - 112, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- OBJECTIVE: Laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS) has been developed to prevent duodenal leakage by reinforcing the endoscopic submucosal dissection site. However, there has been no prospective trial showing the feasibility of D-LECS. Herein, we conducted a single-arm confirmatory trial to evaluate the safety of D-LECS for non-ampullary superficial duodenal neoplasms. METHODS: This prospective single-center single-arm confirmatory trial analyzed patients with non-ampullary superficial duodenal neoplasms who underwent D-LECS. The primary endpoint was the incidence of any postoperative leakage occurring on the duodenal wall within 1 month postoperatively. The planned sample size was 20 patients, considering a threshold of 28% and one-sided alpha value of 5%. RESULTS: Between January 2015 and September 2018, 20 eligible patients were enrolled. Sixteen tumors were located in the second portion, three in the first portion, and one in the third portion of the duodenal region. The median operative time was 225 (134-361) min and the median blood loss was 0 (0-150) mL. Curative resection (R0) with negative margins was achieved in 19 cases. One case of postoperative leakage and one case of bleeding of grade 2 according to the Clavien-Dindo classification were observed in this series. The median duration of postoperative hospital stay was 9 (5-12) days. No local recurrence was observed in any patient during the median follow-up of 15.0 (12.0-38.0) months. CONCLUSIONS: This trial confirmed the safety and feasibility of D-LECS for non-ampullary superficial duodenal neoplasms with respect to the low incidence of postoperative duodenal leakage.2020年04月, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 33(3) (3), 373 - 380, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (株)メディカ出版, 2020年04月, 消化器ナーシング, 25(4) (4), 305 - 311, 日本語
- 金原出版(株), 2020年03月, 手術, 74(4) (4), 510 - 514, 日本語[査読有り]
- BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.2020年03月, Annals of surgical oncology, 27(3) (3), 683 - 690, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Objectives: Dissection of the No. 11p lymph nodes is technically challenging because of variations in anatomical landmarks. This study aimed to determine the accuracy and efficacy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography simulation. Methods: Laparoscopic gastrectomy with No. 11p lymph node dissection with preoperative simulation using three-dimensional computed tomography was performed in 24 patients at our institution from October 2016 to May 2018. Initially, preoperative three-dimensional computed tomography findings with operative videos in these 24 patients were compared. The dorsal landmark was defined as an anatomical structure behind the splenic artery on preoperative three-dimensional computed tomography and operative videos. The dorsal landmark of No. 11p lymph node was divided into four types: (1) splenic vein type, (2) splenic vein and pancreas type, (3) pancreas type, and (4) unclear type. Then, to investigate the efficacy of three-dimensional computed tomography, we compared the clinical and pathological features and surgical outcomes of nine patients who underwent preoperative three-dimensional computed tomography simulation (three-dimensional computed tomography group) and 23 patients who did not undergo three-dimensional computed tomography simulation from August 2014 to September 2016 (non-three-dimensional computed tomography group). All procedures were performed by one surgeon certified by the Endoscopic Surgical Skill Qualification System in Japan. Results: The concordance rate between three-dimensional computed tomography and operative videos of the dorsal landmark using three-dimensional computed tomography was 79% (19/24). The operative time of No. 11p lymph node dissection was significantly shorter in the three-dimensional computed tomography group than in the non-three-dimensional computed tomography group (7.7 versus 15.8 min, P = 0.044). Conclusion: The accuracy of predicting the dorsal landmark of No. 11p lymph node using three-dimensional computed tomography was extremely high. Preoperative simulation with three-dimensional computed tomography was useful in shortening the operative time of No. 11p lymph node dissection.2020年, SAGE open medicine, 8, 2050312120936918 - 2050312120936918, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年12月, 癌と化学療法, 46(13) (13), 2327 - 2329, 日本語, 国内誌虫垂腺癌術後に吻合部再発と診断された神経内分泌癌の1例(原著論文)[査読有り]研究論文（学術雑誌）
- (株)癌と化学療法社, 2019年04月, 癌と化学療法, 46(4) (4), 787 - 789, 日本語
- [A Case Report of Pancreatic Neuroendocrine Tumor Resected with the Preoperative Diagnosis of Gastrointestinal Stromal Tumor of the Jejunum].A 61-year-old man was examined for cervical pain and CT showed a 9 cm tumor to the third part of the duodenum and proximal jejunum. CT /MRI showed that the tumor was separated from the pancreas body. We scheduled a laparoscopic partial resection of the intestine with a suspected diagnosis of GIST of the intestine. The tumor was adhered to both the proximal jejunum and uncinate process of the pancreas. Therefore, we converted to an open surgery and resected part of the pancreas, duodenum, and proximal jejunum including the tumor. Histopathological examination showed the tumor capsule included the tissue of the pancreas and that the border between the intestine and the tumor was clear, suggesting that the origin of the tumor was the pancreas. We diagnosed the patient as having a grade 2 pancreatic neuroendocrine tumor based on the tumor growth pattern and immunohistochemistry findings. We examined the preoperative CT images retrospectively and found that the tumor had adhered to the uncinate process of the pancreas, which extends over the left side of the superior mesenteric artery. When GIST close to the proximal jejunum is suspected, the possibility of pancreatic neuroendocrine tumor should be considered.2019年04月, Gan to kagaku ryoho. Cancer & chemotherapy, 46(4) (4), 787 - 789, 日本語, 国内誌[査読有り]
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS110 - 6, 日本語当院における腹腔鏡下胃切除術定型化の検討
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), DP96 - 9, 日本語回腸導管傍ストマヘルニアに対して腹腔鏡下修復術(Sandwich法)を施行した1例
- 2017年11月, 手術, 71(12) (12), 1645 - 1649, 日本語手術手技 食道胃接合部癌に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と逆流防止を意識した偽fornix・His角形成を伴う食道胃管吻合法(解説)[査読有り]研究論文（学術雑誌）
- 2017年11月, Gan to kagaku ryoho. Cancer & chemotherapy, 44(12) (12), 1431 - 1433[Surgical Dissection for an Abdominal Para-Aortic Lymph Node Recurrence after Curative Resection for Early Gastric Cancer - Report of a Case].[査読有り]
- Impact Journals LLC, 2017年, Oncotarget, 8(62) (62), 106071 - 106088, 英語[査読有り]研究論文（学術雑誌）
- 2016年09月, CANCER LETTERS, 380(1) (1), 47 - 58, 英語[査読有り]研究論文（学術雑誌）
- 2016年02月, PATHOLOGY INTERNATIONAL, 66(2) (2), 83 - 93, 英語[査読有り]研究論文（学術雑誌）
- 2015年11月, 癌と化学療法, 42(12号) (12号), 2202 - 2204, 日本語クローン病長期寛解後に同時性多発大腸癌を発症した1例[査読有り]研究論文（学術雑誌）
- 2015年09月, INTERNATIONAL SURGERY, 100(9-10) (9-10), 1326 - 1331, 英語[査読有り]研究論文（学術雑誌）
- 2015年08月, 癌の臨床, 61(4) (4), 283 - 287, 日本語胃癌における機能温存手術[査読有り]研究論文（学術雑誌）
- 2015年06月, ONCOLOGY LETTERS, 9(6) (6), 2583 - 2585, 英語[査読有り]研究論文（学術雑誌）
- 2015年03月, CANCER MEDICINE, 4(3) (3), 437 - 446, 英語[査読有り]研究論文（学術雑誌）
- 2015年03月, Lab Invest., 95(5) (5), 491 - 503, 英語GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways[査読有り]研究論文（学術雑誌）
- 2015年01月, 医薬ジャーナル, 51(増刊) (増刊), 147 - 155, 日本語新薬展望2015 第III部 治療における最近の新薬の位置付け<薬効別> ～新薬の広場～ 消化器癌治療薬[査読有り]研究論文（学術雑誌）
- 2013年08月, CANCER SCIENCE, 104(8) (8), 1112 - 1119, 英語[査読有り]研究論文（学術雑誌）
- 医学書院, 2012年05月, 臨床外科, 67(5) (5), 727 - 731, 日本語両側卵巣転移を伴う妊娠併存S状結腸癌の1例
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 350 - 350, 日本語遠位直腸癌における術前放射線化学療法効果予測に関する解析[査読有り]
■ 講演・口頭発表等
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からのアプローチの有用性の検討シンポジウム・ワークショップパネル（公募）
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性についての検討口頭発表（一般）
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議切除困難な胃GISTに対する術前イマチニブによる補助療法の有用性に関する検討シンポジウム・ワークショップパネル（公募）
- 第96回日本胃癌学会総会, 英語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議The significance of conversion surgery following chemotherapy for clinical stage IV gastric cancer口頭発表（一般）
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議当院における進行胃癌に対するロボット支援下胃切除術の工夫口頭発表（一般）
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性シンポジウム・ワークショップパネル（公募）
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討口頭発表（一般）
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績シンポジウム・ワークショップパネル（公募）
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績；術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略口頭発表（一般）
- The 19th Annual Academic Surgical Congress, 英語, Annual Academic Surgical Congress, Washington, D.C., アメリカ合衆国, 国際会議Clinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRT口頭発表（一般）
- 第207回近畿外科学会, 日本語, 関西医科大学 外科学講座, 枚方市, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性についての検討口頭発表（一般）
- 第207回近畿外科学会, 日本語, 関西医科大学 外科学講座, 枚方市, 日本国, 国内会議リンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性口頭発表（一般）
- 第207回近畿外科学会, 日本語, 関西医科大学 外科学講座, 枚方市, 日本国, 国内会議十二指腸・小腸（研修医）その他
- 日本消化器病学会近畿支部第120回例会, 日本語, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, 日本国, 国内会議当院におけるTaTME併用大腸全摘術の手術成績シンポジウム・ワークショップパネル（公募）
- 第194回兵庫県外科医会学術集会, 日本語, 兵庫県外科医会, 神戸, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討口頭発表（一般）
- 第36回日本バイオセラピィ学会学術集会総会, 日本語, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, 日本国, 国内会議深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索口頭発表（一般）
- 第36回日本バイオセラピィ学会学術集会総会, 日本語, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, 日本国, 国内会議大腸癌腫瘍免疫微小環境における CD4＋T 細胞に与える肥満の影響口頭発表（一般）
- 第14回神戸栄養研究会, 日本語, 神戸大学医学部附属病院 栄養・輸液サポートチーム（NEST）・アボットジャパン合同会社, 神戸/Web, 日本国, 国内会議特別講演「減量・代謝改善手術にまつわる栄養管理と注意点」その他
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議安全な Collard 変法吻合を目指した変革と短期成績口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議ロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議ロボット支援胃切除術におけるリンパ節郭清時間の learning curve口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomy口頭発表（一般）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議経肛門アプローチ併用による２チーム側方郭清の手術手技と手術成績シンポジウム・ワークショップパネル（公募）
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議人間工学に基づく「鏡視下クロソイド・カーブ針」の開発口頭発表（一般）
- KOBEヘルニアセミナー, 日本語, コヴィディエンジャパン株式会社, 神戸/Web, 日本国, 国内会議閉会の辞その他
- KOBEヘルニアセミナー, 日本語, コヴィディエンジャパン株式会社, 神戸/Web, 日本国, 国内会議Liechtenstein 手技ハンズオンその他
- KOBEヘルニアセミナー, 日本語, コヴィディエンジャパン株式会社, 神戸/Web, 日本国, 国内会議特別講演「International Guidelinesを視野に～ Lichtenstein & TAPP ～」その他
- 第44回日本肥満学会・第41回日本肥満症治療学会学術集会, 日本語, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, 日本国, 国内会議当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討ポスター発表
- 第34回日本消化器癌発生学会総会, 日本語, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, 日本国, 国内会議深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索シンポジウム・ワークショップパネル（公募）
- 第34回日本消化器癌発生学会総会, 日本語, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, 日本国, 国内会議大腸癌手術前後における腸内細菌と代謝物の変化についての検討シンポジウム・ワークショップパネル（公募）
- 第34回日本消化器癌発生学会総会, 日本語, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, 日本国, 国内会議放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態シンポジウム・ワークショップパネル（公募）
- 第74回日本気管食道科学会総会ならびに学術講演会, 日本語, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, 日本国, 国内会議高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性口頭発表（一般）
- 第74回日本気管食道科学会総会ならびに学術講演会, 日本語, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, 日本国, 国内会議リンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性口頭発表（一般）
- 第3回兵庫胃ビデオカンファレンス, 日本語, コヴィディエンジャパン株式会社, 神戸, 日本国, 国内会議ビデオディスカッション「hinotori導入1例目の振り返り」その他
- 第26回腹腔鏡内視鏡合同手術研究会, 日本語, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討口頭発表（一般）
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, 英語, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, 日本国, 国際会議Clinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRTポスター発表
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, 英語, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, 日本国, 国際会議The advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resectionポスター発表
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議The significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resection口頭発表（一般）
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議Albumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinoma口頭発表（一般）
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議Clinical outcomes of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for metastasised low rectal cancer口頭発表（一般）
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議腹腔鏡下に切除し得た成人骨盤嚢胞性腫瘤の２例口頭発表（一般）
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議下部直腸癌に対するTaTMEの有用性とラーニングカーブシンポジウム・ワークショップパネル（公募）
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議リンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性シンポジウム・ワークショップパネル（公募）
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議当院におけるロボット支援下結腸切除術の導入 10例の経験シンポジウム・ワークショップパネル（公募）
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), 英語, The Korean Gastric Cancer Association, Seoul, 大韓民国, 国際会議The advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resection口頭発表（一般）
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), 英語, The Korean Gastric Cancer Association, Seoul, 大韓民国, 国際会議Efficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancer口頭発表（一般）
- 第2回～Anastomosis Master～, 日本語, ジョンソン・エンド・ジョンソン株式会社, 神戸, 日本国, 国内会議器械吻合におけるコツとピットフォールその他
- 第1回Hanshin-GI, 日本語, 大鵬薬品工業株式会社, 大阪/Web, 日本国, 国内会議胃癌術後補助化学療法の現状その他
- 第3回神戸ラパロ道場, 日本語, コヴィディエンジャパン株式会社, 神戸, 日本国, 国内会議上部セッションその他
- 第3回神戸ラパロ道場, 日本語, コヴィディエンジャパン株式会社, 神戸, 日本国, 国内会議第3回神戸ラパロ道場開催についてその他
- 第33回日本サイトメトリー学会学術集会, 日本語, 杏林大学大学院医学研究科 共同研究施設フロ−サイトメトリ−部門, Web, 日本国, 国内会議深層学習に基づくイメージサイトメトリーによる直腸癌の新規予後因子の探索ポスター発表
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議直腸癌の術前化学放射線療法への抵抗性における Wnt/β-catenin シグナル活性化の重要性口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議高齢胃癌患者への内視鏡治療後非治癒切除症例における予後因子の検討口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議当院における TaTME 併用大腸全摘術の手術成績の検討シンポジウム・ワークショップパネル（公募）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議術中診断にて漿膜浸潤以上の深達度であった進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討シンポジウム・ワークショップパネル（公募）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議当院における進行胃癌に対するロボット支援下胃切除術の短期治療成績の検討口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議ASA 分類 Class 3 以上の大腸癌患者に対する腹腔鏡手術と開腹手術の比較検討口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議高齢者食道癌患者に対する胸腔鏡下食道切除術口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議短期・長期成績からみた下部直腸癌に対するTaTME の有用性について口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議高齢者に対する胸腔鏡下食道切除後の経腸栄養は sarcopenia を予防できるか?口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議鼠経転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議十二指腸浸潤を伴う胃癌に対する胃切除術の安全性の検討口頭発表（一般）
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議ロボット支援下食道切除術の術者育成口頭発表（一般）
- 第99回大腸癌研究会学術集会, 日本語, 関西労災病院 外科, 尼崎, 日本国, 国内会議下部直腸癌に対するTaTMEの有用性とラーニングカーブ口頭発表（一般）
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議高齢者に対する腹臥位胸腔鏡下食道切除術ポスター発表
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議全周性かつ表層拡大食道癌症例の特徴と手術治療成績ポスター発表
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議食道胃接合部癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性シンポジウム・ワークショップパネル（公募）
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議短期・長期成績からみたロボット支援食道切除術のエビデンスシンポジウム・ワークショップパネル（公募）
- 第11回若手消化器外科腹腔鏡セミナー, 日本語, 神戸大学大学院医学研究科外科学講座 食道胃腸外科学分野・肝胆膵外科学分野, 神戸, 日本国, 国内会議基調講演1 腹腔鏡鼠径ヘルニア修復術のポイントその他
- 第44回癌免疫外科研究会, 日本語, 千葉大学大学院医学研究院 先端応用外科, 千葉, 日本国, 国内会議化学放射線治療による腫瘍微小環境の変化～深層学習に基づくイメージサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索～口頭発表（一般）
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, Yokohama, 日本国, 国内会議Neutrophil lymphocyte ratio and histological response correlate with prognosis of gastric cancer undergoing neoadjuvant chemotherapy口頭発表（一般）
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, Yokohama, 日本国, 国内会議Safety of laparoscopic gastrectomy for advanced gastric cancer with greater than serosal invasion depth口頭発表（一般）
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, Yokohama, 日本国, 国内会議The prognostic factors of early gastric cancer in elderly patients after non-curative endoscopic resection口頭発表（一般）
- 第193回兵庫県外科医会学術集会, 日本語, 兵庫県外科医会, 神戸, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績口頭発表（一般）
- 第66回関西胸部外科学会学術集会, 日本語, JCHO大阪病院, 大阪, 日本国, 国内会議高齢者食道癌患者に対する胸腔鏡下食道切除術シンポジウム・ワークショップパネル（公募）
- 第66回関西胸部外科学会学術集会, 日本語, JCHO大阪病院, 大阪, 日本国, 国内会議進行食道癌に対するロボット支援下食道切除シンポジウム・ワークショップパネル（公募）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議食道切除 ・ 胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチポスター発表
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議The mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT.口頭発表（一般）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討口頭発表（一般）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議大量の難治性乳び腹水を伴う直腸間膜リンパ管嚢腫破裂に対して手術加療を施行した 1 例その他
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議当院における TaTME 併用による大腸全摘術、 回腸嚢肛門吻合術の手術成績シンポジウム・ワークショップパネル（公募）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議高齢胃癌患者の内視鏡治療後非治癒切除症例における予後因子の検討シンポジウム・ワークショップパネル（公募）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議血行再建を伴う胸壁前有茎空腸再建術の有用性シンポジウム・ワークショップパネル（公募）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議膵臓側に位置する表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の工夫シンポジウム・ワークショップパネル（公募）
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議自律神経を意識した腹臥位胸腔鏡下食道切除術シンポジウム・ワークショップパネル（公募）
- 第45回日本癌局所療法研究会, 日本語, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, 日本国, 国内会議鼠径部転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績口頭発表（一般）
- 第45回日本癌局所療法研究会, 日本語, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, 日本国, 国内会議直腸癌の術前化学放射線療法への抵抗性における Wnt/ β -catenin シグナル活性化の重要性口頭発表（一般）
- 第21回日本ヘルニア学会学術集会, 日本語, 大阪府済生会吹田病院へルニアセンター, 大阪, 日本国, 国内会議一般演題（口演）34 手術術前併存疾患その他
- 第21回日本ヘルニア学会学術集会, 日本語, 大阪府済生会吹田病院へルニアセンター, 大阪, 日本国, 国内会議当科における全身合併症を伴う鼠径部ヘルニア手術の周術期管理の安全性の検討シンポジウム・ワークショップパネル（公募）
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績シンポジウム・ワークショップパネル（公募）
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議当院における経肛門的アプローチ併用による大腸全摘出の手術手技シンポジウム・ワークショップパネル（公募）
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議当院におけるロボット支援下胃切除術のメインデバイスの変遷シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議オープンソースの物体検出アルゴリズム YOLOv3 を用いた胸腔鏡下食道亜全摘術の手術動画解析シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績ポスター発表
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議食道切除後長期の腸瘻での栄養管理はサルコペニアを予防するシンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議AI 病理診断システムを用いた直腸癌の新規予後因子の探索シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議局所進行直腸癌術前療法における腫瘍内レジデントメモリー CD8+T 細胞の動態とその役割シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議Diversity からさらに未来へ～Diversity だけで十分ですか？ ～その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議経肛門アプローチによる側方郭清の標準化手術手技と手術成績シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議食道胃接合部癌に対する経裂孔的腹腔鏡下 y 字型食道胃管吻合の有用性シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討シンポジウム・ワークショップパネル（公募）
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議cStageIV 胃癌の conversion surgery における周術期化学療法の検討シンポジウム・ワークショップパネル（公募）
- 第206回近畿外科学会, 日本語, 兵庫医科大学 上部消化管外科, 大阪, 日本国, 国内会議若手 Surgeon が進化させるラパロ胃癌手術公開講演，セミナー，チュートリアル，講習，講義等
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討シンポジウム・ワークショップパネル（公募）
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性の検討ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議当院におけるCY1を伴う進行胃癌に対する集学的治療戦略ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議胃癌切除例におけるpoorly cohesive carcinomaの臨床病理学的特徴と予後に関する検討シンポジウム・ワークショップパネル（公募）
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議新規半消化態栄養剤を用いた胃癌術後経口栄養療法の安全性に関する検討ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議腹腔鏡下経裂孔アプローチにおける左横隔膜開放法による下縦隔郭清・再建の安全性に関する検討ポスター発表
- 第55回制癌剤適応研究会, 日本語, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, 日本国, 国内会議StageIV胃癌のconversion surgeryにおける周術期化学療法と予後の検討シンポジウム・ワークショップパネル（公募）
- The 18th Annual Academic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, アメリカ合衆国, 国内会議The mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT口頭発表（一般）
- The 18th Annual Academic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, アメリカ合衆国, 国内会議Risk factor for stricture after cervical triangular anastomosis in Minimally Invasive Esophagectomyその他
- 第19回日本消化管学会総会学術集会, 日本語, 日本医科大学消化器内科学・日本医科大学付属病院消化器・肝臓内科, 東京, 日本国, 国内会議胃癌・食道胃接合部癌の術前化学療法効果診断における組織学的効果判定および宿主免疫指標マーカーの有用性の検討シンポジウム・ワークショップパネル（公募）
- 第98回大腸癌研究会学術集会, 日本語, 順天堂大学大学院医学研究科・人体病理病態学, 東京, 日本国, 国内会議当院における若年者大腸癌手術症例の検討ポスター発表
- 日本消化器病学会近畿支部第118回例会, 日本語, 京都府立医科大学大学院医学研究科消化器外科学, 京都, 日本国, 国内会議一般演題5 腫瘍・その他その他
- 日本消化器病学会近畿支部第118回例会, 日本語, 京都府立医科大学大学院医学研究科消化器外科学, 京都, 日本国, 国内会議食道胃接合部腺癌に対する当科の治療戦略シンポジウム・ワークショップパネル（公募）
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), 英語, Fujita Health University Hospital International Medical Center, Nagoya/web, 日本国, 国内会議Hybrid abdominal robotic approach with TaTME for low rectal cancerシンポジウム・ワークショップパネル（公募）
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), 英語, Fujita Health University Hospital International Medical Center, Nagoya/web, 日本国, 国内会議Novel “Modified Bascule method” for lymphadenectomy along the left recurrent laryngeal nerve during robot-assisted minimally invasive esophagectomy口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議食道癌に対する腹臥位胸腔鏡下食道切除術の短期・長期成績口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議腫瘍深達度が漿膜浸潤以上の進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議直腸癌に対する Abdominal robotic approach 併用による Hybrid TaTME口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議Transanal アプローチ併用側方郭清の治療成績と安全に行うための工夫口頭発表（一般）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議当科における残胃癌に対する腹腔鏡下残胃全摘術の手術成績と予後の検討シンポジウム・ワークショップパネル（公募）
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議ロボット支援食道切除の短期成績 - 胸腔鏡手術との比較 -シンポジウム・ワークショップパネル（公募）
- 第26回日本バイオ治療法学会学術集会, 日本語, 徳島大学大学院社会産業理工学研究部生物資源産業学域, 大阪, 日本国, 国内会議AI 病理診断システムを用いた直腸癌の新規予後因子の探索口頭発表（一般）
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, 日本語, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座（第二内科）・大分大学医学部 消化器・小児外科学講座, 那覇, 日本国, 国内会議肥満が大腸癌腫瘍微小環境のCD4陽性T細胞に及ぼす影響口頭発表（一般）
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, 日本語, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座（第二内科）・大分大学医学部 消化器・小児外科学講座, 那覇, 日本国, 国内会議COVID19 感染下における腹腔鏡下スリーブ状胃切除術の導入と短期治療成績口頭発表（一般）
- 第35回日本バイオセラピィ学会学術集会総会, 日本語, 福島県立医科大学 消化管外科学講座, 福島, 日本国, 国内会議大腸癌の腫瘍免疫微小環境における CD4 陽性T細胞に与える肥満の影響口頭発表（一般）
- 第35回日本バイオセラピィ学会学術集会総会, 日本語, 福島県立医科大学 消化管外科学講座, 福島, 日本国, 国内会議放射線治療における腫瘍内 CD8+T細胞の動態シンポジウム・ワークショップパネル（公募）
- 第84回日本臨床外科学会総会, 日本語, 久留米大学医学部外科学講座, 福岡, 日本国, 国内会議周術期チーム医療による腹臥位胸腔鏡下食道切除術シンポジウム・ワークショップパネル（公募）
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議残胃癌に対する腹腔鏡下残胃全摘術の手術成績の検討シンポジウム・ワークショップパネル（公募）
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議幽門側胃切除後の残胃内容排出遅延に関する検討シンポジウム・ワークショップパネル（公募）
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表（一般）
- 第33回日本消化器癌発生学会総会, 日本語, 東京大学大学院医学系研究科消化管外科学, 東京/Web, 日本国, 国内会議大腸癌のおけるCD4陽性T細胞の抗腫瘍免疫に及ぼす肥満の影響シンポジウム・ワークショップパネル（公募）
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, 英語, Korean Surgical Society, Seoul, 大韓民国, 国内会議Laparoscopic Endoscopic Cooperative Surgery Using Openwindow Suturing Technique for Treating Non-ampullary Superficial Duodenal Neoplasms Located on the Pancreatic Side口頭発表（一般）
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, 英語, Korean Surgical Society, Seoul, 大韓民国, 国内会議Comparison of Laparoscopic Gastrectomy for Gastric Cancer with 3D and 2D Monitorsシンポジウム・ワークショップパネル（公募）
- JDDW2022(第30回日本消化器関連学会週間), 日本語, 一般社団法人 日本消化器関連学会機構（JDDW）, 福岡/Web, 日本国, 国内会議食道胃接合部に近接する胃消化管間質腫瘍に対する腹腔鏡下局所切除の安全性についての検討ポスター発表
- JDDW2022(第30回日本消化器関連学会週間), 日本語, 一般社団法人 日本消化器関連学会機構（JDDW）, 福岡/Web, 日本国, 国内会議オープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析ポスター発表
- JDDW2022(第30回日本消化器関連学会週間), 日本語, 一般社団法人 日本消化器関連学会機構（JDDW）, 福岡/Web, 日本国, 国内会議当院における食道胃接合部腺癌に対する治療戦略シンポジウム・ワークショップパネル（公募）
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表（一般）
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議cStageIV胃癌に対するconversion surgeryの手術成績と予後因子の検討シンポジウム・ワークショップパネル（公募）
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議鼠経リンパ節転移を伴う直腸癌に対する術前治療と選択的鼠経郭清の臨床的意義ポスター発表
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議術前化学療法における Alb/ dNLR の推移は食道癌の予後に関与するかポスター発表
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議直腸癌術前化学放射線療法の予後因子としての modified Glasgow Prognostic Score口頭発表（一般）
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議直腸癌術前化学放射線療法における AI を用いた腫瘍組織 CD8+T 細胞の評価方法の検討口頭発表（一般）
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議FDG-PET/CTによる進行胃癌の病理学的病期の術前予測の有用性ポスター発表
- 第75回日本胸部外科学会定期学術集会, 日本語, 東京大学医学部附属病院 呼吸器外科, 横浜/Web, 日本国, 国内会議腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較（LAP vs HALS）口頭発表（一般）
- 18th ISDE World Congress for Esophageal Diseases, 英語, International Society for Diseases of the Esophagus, Web, 日本国, 国内会議Comparison of Laparoscopic Surgeries With or Without Hand-Assisted Procedure in the Abdominal Phase of Thoracoscopic Esophagectomy in the Prone Positionポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, 日本国ロボット支援食道切除術の利点と課題ポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, 日本国Albumin-derived NLR score is a novel prognostic marker for esophageal squamous cell carcinomaポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, 日本国胸腔鏡下食道切除症例における栄養介入としての腸瘻チューブ留置期間の検討ポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, 日本国腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較（LAP vs HALS）口頭発表（一般）
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京/Web, 日本国低侵襲と合併症リスクの低減を目指した腹腔鏡下胸骨後経路作成の術後成績口頭発表（一般）
- ～Anastomosis Master～, 日本語, ジョンソン・エンド・ジョンソン株式会社, 神戸, 日本国器械吻合におけるコツとピットフォール公開講演，セミナー，チュートリアル，講習，講義等
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国, 国内会議当院における右側結腸癌に対する体腔内吻合の導入と治療成績口頭発表（一般）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国当院における右側結腸癌に対する対腔内吻合の導入と治療成績口頭発表（一般）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国Siewert Ⅱ型接合部癌に対する経裂孔的アプローチによる下縦隔リンパ節郭清シンポジウム・ワークショップパネル（公募）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国食道切除・胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチ口頭発表（一般）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国膵･十二指腸･横行結腸浸潤を伴う胃癌に対し術前化学療法奏効後に腹腔鏡下幽門側胃切除術を施行した一例口頭発表（一般）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国腹臥位胸腔鏡下食道切除における当科の郭清概念シンポジウム・ワークショップパネル（公募）
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 西宮, 日本国直腸癌手術におけるTaTMEの有用性シンポジウム・ワークショップパネル（公募）
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), 英語, The Korean Gastric Cancer Association, Korea, 大韓民国Preoperative Prediction of the Pathological Stage of Advanced Gastric Cancer by 18F-fluoro-2-deoxyglucose Positron Emission Tomography口頭発表（一般）
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), 英語, The Korean Gastric Cancer Association, Korea, 大韓民国Assessment of Risk Factors for Delayed Gastric Emptying After Distal Gastrectomy for Gastric Cancer口頭発表（一般）
- 第77回日本消化器外科学会総会, 英語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国Laparoscopic retrosternal route creation for gastric conduit - efficacy and outcomes 腹腔鏡による胸骨後経路作成の工夫と術後成績シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 英語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国Development of a new method for evaluation of rectal cancer after neoadjuvant chemoradiotherapy 直腸癌術前化学放射線療法における腫瘍組織CD8+T細胞の新たな評価方法の開発シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国術前サルコペニアの層別化による短期・長期リスク評価の有用性口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国胃癌におけるFDG-PET検査によるリンパ節SUVmax値を用いたリンパ節転移診断の有用性の検討口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国抗凝固療法中の患者に対する胃切除術の安全性について口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国胸腔鏡下食道切除症例における腸瘻チューブ留置による栄養介入とその意義シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国当院における右側結腸癌に対する体腔内吻合の手術手技と短期成績口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国cStageⅣ胃癌に対するconversion surgeryの治療成績シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国胃癌大弯側リンパ節郭清時に周囲リンパ節の郭清ラインとの連続性を意識した#4sb郭清手技の有用性シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国低肺機能患者に対する腹臥位胸腔鏡下食道切除術口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国直腸悪性腫瘍に対するHybrid手術の短期成績に関する後ろ向き研究口頭発表（一般）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国Siewert II型食道胃接合部癌に対する偽His角・穹窿部を付加したy字様Overlap食道胃管吻合の有用性シンポジウム・ワークショップパネル（公募）
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 横浜/Web, 日本国頭側アプローチによる腹腔鏡下結腸右半切除～術者経験を考慮した段階的導入と定型化～シンポジウム・ワークショップパネル（公募）
- 第2回神戸ラパロ道場, 日本語, コヴィディエンジャパン株式会社, Web, 日本国上部セッション公開講演，セミナー，チュートリアル，講習，講義等
- 第97回大腸癌研究会学術集会, 日本語, 埼玉医科大学総合医療センター 消化管・一般外科, 東京/Web, 日本国閉塞性大腸癌患者に対する腹腔鏡下手術の術前自己拡張型金属ステントの有用性口頭発表（一般）
- 第3回Trends＆Topics UGIS in Hyogo, 日本語, ジョンソン・エンド・ジョンソン株式会社, 神戸, 日本国食道胃接合部がん：これどうする？ 症例提示①公開講演，セミナー，チュートリアル，講習，講義等
- 第44回日本癌局所療法研究会, 日本語, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, 日本国遠隔転移を有するHER2陽性進行胃癌に対しConversion Surgeryを施行し奏効を得た1例口頭発表（一般）
- 第44回日本癌局所療法研究会, 日本語, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, 日本国食道癌に対するESD後の良性狭窄に対し食道バイパス手術によりQOL向上を得られた一例口頭発表（一般）
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 鳴門/Web, 日本国術前化学療法における Alb-dNLR ratioの推移は食道癌の予後に関与するかポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 鳴門/Web, 日本国大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響ポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 鳴門/Web, 日本国放射線治療における腫瘍内 CD8+T 細胞の動態シンポジウム・ワークショップパネル（公募）
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 鳴門/Web, 日本国cStageIV胃癌に対するconversion surgeryの予後の検討ポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 鳴門/Web, 日本国低侵襲治療を目指したロボット支援下胃切除術の導入と短期治療成績ポスター発表
- 第65回関西胸部外科学会学術集会, 日本語, 浜松医科大学 外科学第一講座, 浜松, 日本国食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチシンポジウム・ワークショップパネル（公募）
- AOS 2022（2nd International Congress of ASIAN ONCOLOGY SOCIETY), 英語, Asian Oncology Society, Korea, 大韓民国Thoracic cavity-to-cage ratio is a predictor of technical difficulties in minimally invasive esophagectomy口頭発表（一般）
- 第43回癌免疫外科研究会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, 日本国腫瘍抗原導入樹状細胞にiNKT細胞リガンドを付加したワクチンは、抗原特異的な抗腫瘍免疫を効果的に誘導するシンポジウム・ワークショップパネル（公募）
- 第43回癌免疫外科研究会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, 日本国放射線治療における腫瘍内CD8+T細胞の動態シンポジウム・ワークショップパネル（公募）
- 第76回手術手技研究会, 日本語, 佐賀大学医学部 一般・消化器外科, 佐賀/Web, 日本国腹腔鏡による胸骨後経路作成の工夫と短期成績シンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国術前化学療法におけるAlb/dNLRの推移は食道癌の予後に関与するかシンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国術前欠損歯数が胃癌予後に及ぼす影響についての検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国サルコペニアの層別化によるリスク評価の有用性ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国MIE施行症例における術前血小板リンパ球比の予後予測因子としての有用性シンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国当科における下部進行直腸癌に対する治療戦略シンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国高齢胃癌患者への内視鏡治療後非治癒切除症例における予後の検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国胃・食道胃接合部癌術前化学療法における予後予測因子の検討シンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国2チームによるTaTMEは狭骨盤や肥満による腹腔鏡下直腸癌手術の困難さを緩和するシンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国直腸癌術前化学放射線療法における腫瘍内レジデントメモリーCD8+T細胞の動態とその予後シンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国下部直腸癌に対するTaTMEと融合させたRobotic surgeryシンポジウム・ワークショップパネル（公募）
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本市/Web, 日本国ロボット支援食道切除におけるlearning curveと手技の工夫シンポジウム・ワークショップパネル（公募）
- 第94回日本胃癌学会総会, 英語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国The Signicance of Surgical Intervention Following Chemotherapy for Stage IV Gastric Cancer口頭発表（一般）
- 第94回日本胃癌学会総会, 英語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国Safety management of laparoscopic endoscopic cooperative surgery for duodenal tumorシンポジウム・ワークショップパネル（公募）
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, 日本国幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討シンポジウム・ワークショップパネル（公募）
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, 日本国抗血栓療法中の患者に対する胃癌手術の安全性の検討ポスター発表
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜/Web, 日本国da Vinci Harmonicによるロボット支援下幽門側胃切除術の時間短縮効果と短期治療成績の検討口頭発表（一般）
- 第14回日本ロボット外科学会学術集会, 日本語, 鹿児島大学医学部産科婦人科, Web, 日本国ロボット支援食道切除における反回神経麻痺低減の試みシンポジウム・ワークショップパネル（公募）
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, 日本国癌幹細胞マーカーは食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるシンポジウム・ワークショップパネル（公募）
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, 日本国大腸癌腹膜播種モデルにおける骨髄由来免疫抑制細胞の機能シンポジウム・ワークショップパネル（公募）
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web/誌上開催, 日本国術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義シンポジウム・ワークショップパネル（公募）
- 兵庫ヘルニアビデオカンファレンス, 日本語, コヴィディエンジャパン株式会社, Web, 日本国司会公開講演，セミナー，チュートリアル，講習，講義等
- 日本消化器病学会近畿支部第116回例会, 日本語, 兵庫医科大学 消化器内科学, 大阪/Web, 日本国Freshman Session5 食道・胃公開講演，セミナー，チュートリアル，講習，講義等
- 17th Annual Acasemic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, America, アメリカ合衆国Assessing The Risk Factors for Delayed Gastric Emptying after Distal Gastrectomy for Gastric Cancer口頭発表（一般）
- 第96回大腸癌研究会, 日本語, 帝京大学医学部外科学講座, 東京/Web, 日本国当科における経肛門アプローチ併用による側方リンパ節郭清の手術成績口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語低肺機能に対する腹臥位胸腔鏡下食道切除術口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道切除術においてenergy deviceが短期成績に及ぼす影響シンポジウム・ワークショップパネル（公募）
- 第34回日本内視鏡外科学会総会, 日本語左結腸動脈処理に着目した腹腔鏡下左側結腸癌手術口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語当院における右側結腸癌に対する体腔内吻合の導入と治療成績口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語腹腔鏡下胃切除症例における周術期抗血栓療法の安全性の検討口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語当院におけるロボット支援下幽門側胃切除術の手技定型化の確立と短期治療成績口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道手術による反回神経麻痺の軽減に関する試み口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語直腸癌手術におけるTransanal minimally invasive ISRの有用性と課題口頭発表（一般）
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道切除における至適剥離層シンポジウム・ワークショップパネル（公募）
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語直腸癌に対するAbdominal robotic approach併用によるHybrid TaTMEポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語大腸癌術後の早期再発のリスク因子ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語癌幹細胞マーカーは、食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語腫瘍抗原導入樹状細胞にα-GalCerを付加したワクチンベクターの抗腫瘍効果ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語当科におけるStageⅣ胃癌に対するconversion surgeryの治療成績ポスター発表
- 第30回日本コンピュータ外科学会大会, 日本語胸腔鏡下食道切除術における3D内視鏡システムは術後短期の改善に寄与する口頭発表（一般）
- 第30回日本コンピュータ外科学会大会, 日本語ロボット支援食道切除手術におけるlearning curve口頭発表（一般）
- 第30回日本コンピュータ外科学会大会, 日本語3D/HDおよび2D/4Kモニターが術者技術レベルごとの手術操作にもたらす影響口頭発表（一般）
- 第30回日本コンピュータ外科学会大会, 日本語3D‒CT を用いた骨盤計測と直腸癌手術時間との関連―通常の腹腔鏡下手術と Transanal Total Mesorectal Excision との違い―口頭発表（一般）
- 第83回日本臨床外科学会総会, 日本語一般示説 食道胃接合部癌その他
- 第72回日本気管食道科学会総会ならびに学術講演会, 日本語オープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析シンポジウム・ワークショップパネル（公募）
- 第72回日本気管食道科学会総会ならびに学術講演会, 日本語胸腔鏡下食道切除術における嚥下性肺炎の予防シンポジウム・ワークショップパネル（公募）
- 第51回胃外科・術後障害研究会, 日本語幽門側胃切除後の残胃内容排出遅延に関する検討シンポジウム・ワークショップパネル（公募）
- 第51回胃外科・術後障害研究会, 日本語高齢者胃癌術後の肺炎併発が長期予後へ与える影響の検討シンポジウム・ワークショップパネル（公募）
- 第22回腹腔鏡内視鏡合同研究会, 2021年11月, 日本語膵臓側に位置する表在性非乳頭部十二指腸に対する腹腔鏡内視鏡合同手術の工夫口頭発表（一般）
- 第59回日本癌治療学会学術集会, 日本語TaTMEを軸とした近未来の下部直腸癌手術シンポジウム・ワークショップパネル（公募）
- 日本外科代謝栄養学会第58回学術集会, 日本語胃癌手術症例における欠損歯が予後に及ぼす影響について口頭発表（一般）
- 日本外科代謝栄養学会第58回学術集会, 日本語食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発口頭発表（一般）
- 第27回外科侵襲とサイトカイン研究会, 2021年10月, 日本語大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響シンポジウム・ワークショップパネル（公募）
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), 英語Surgical techniques and potential of mediastinal lymphadenectomy in robotic surgery口頭発表（一般）
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), 英語Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer口頭発表（一般）
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), 英語Laparoscopic creation of retrosternal route for gastric conduit reconstruction; safe and feasible procedure口頭発表（一般）
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), 英語Prone Thoracoscopic Esophagectomy for Patients with Low Pulmonary Function
- 17th ISDE World Congress for Esophageal Diseases(ISDE2021), 英語A case of G-CSF(granulocyte-colony stimulating factor) producing esophageal cancer with enteroblastic differentiationポスター発表
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語ロボット支援食道切除術の短期成績と learning curve口頭発表（一般）
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語腹臥位胸腔鏡下食道切除術における上縦隔郭清手技の工夫と定型化口頭発表（一般）
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語当院における腹腔鏡下胃切除を安全に行うためのちょっとした工夫シンポジウム・ワークショップパネル（公募）
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語直腸癌手術における Robotic TaTME の可能性シンポジウム・ワークショップパネル（公募）
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語当科におけるロボット支援食道手術の課題と可能性シンポジウム・ワークショップパネル（公募）
- 第75回日本食道学会学術集会Laparoscopic retrosternal route creation; short-term postoperative outcomesポスター発表
- 第75回日本食道学会学術集会Safety and validity of thoracoscopic esophagectomy for elderly patientsシンポジウム・ワークショップパネル（公募）
- 第75回日本食道学会学術集会Established upper mediastinum lymphadenectomy in prone MIE improves outcomes口頭発表（一般）
- 第75回日本食道学会学術集会Validity of lymphadenectomy for No.106recL estimated by Efficacy Index口頭発表（一般）
- 第30回消化器疾患病態治療研究会, 日本語直腸癌術後縫合不全は長期予後を悪化させるのか?マウスモデルと臨床研究で得られた結果からの考察口頭発表（一般）
- 第30回日本がん転移学会学術集会・総会, 日本語FDG-PET検査によるリンパ節SUVmax値を用いた胃癌リンパ節転移診断の有用性の検討ポスター発表
- 第30回日本がん転移学会学術集会・総会, 日本語StageIV切除不能胃癌に対する外科治療シンポジウム・ワークショップパネル（公募）
- 第30回日本がん転移学会学術集会・総会, 日本語大腸癌腹膜播種モデルにおけるPMN-MDSCの役割ポスター発表
- 第2回Trends & Topics UGIS in Hyogo, 2021年07月, 日本語肥満手術その他
- 第76回日本消化器外科学会総会, 日本語飽和食塩溶液固定法を用いたCadaver Surgical Trainingの有用性シンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会, 日本語腹腔鏡による胸骨後経路作成の工夫と短期成績口頭発表（一般）
- 第76回日本消化器外科学会総会, 日本語食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発と臨床的意義口頭発表（一般）
- 第76回日本消化器外科学会総会, 日本語至適術前治療選択のためのバイオマーカーの重要性口頭発表（一般）
- 第76回日本消化器外科学会総会, 日本語当院における胃・食道胃接合部癌に対する術前化学療法の治療成績の検討シンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会, 日本語taTMEを安全に行うための工夫と手術成績，そして今後の展望シンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会Potential of robotic surgery surpassing conventional thoracoscopic esophagectomyシンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会Simple and reliable transhiatal laparoscopic reconstruction for Siewert type II tumorシンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会Established upper mediastinum lymphadenectomy in prone MIE improves outcomesシンポジウム・ワークショップパネル（公募）
- 第76回日本消化器外科学会総会Short-Term Outcomes of Robot-Assisted Minimally invasive esophagectomyシンポジウム・ワークショップパネル（公募）
- 第31回日本サイトメトリー学会学術集会, 日本語放射線治療における腫瘍内CD8⁺T細胞の動態口頭発表（一般）
- 第31回日本サイトメトリー学会学術集会, 日本語大腸癌腹膜播腫モデルにおける骨髄由来免疫抑制細胞の機能口頭発表（一般）
- 第46回日本外科系連合学会学術集会, 日本語Abdominal robotic approach 併用によるHybrid taTMEの安全性シンポジウム・ワークショップパネル（公募）
- 第46回日本外科系連合学会学術集会, 日本語当院におけるロボット支援下幽門側胃切除術の短期治療成績と定型化に向けた取り組みシンポジウム・ワークショップパネル（公募）
- 第46回日本外科系連合学会学術集会, 日本語食道癌術後患者においてcomprehensive complication indexが予後に及ぼす影響シンポジウム・ワークショップパネル（公募）
- 神戸ラパロ道場KickOff, 2021年06月, 日本語神戸ラパロ道場開催について公開講演，セミナー，チュートリアル，講習，講義等
- 第43回日本癌局所療法研究会, 2021年05月, 日本語右水腎症を伴う進行直腸癌に対し術前化学療法を施行し、病理学的完全奏功を得た1例口頭発表（一般）
- 第75回手術手技研究会, 日本語食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチ口頭発表（一般）
- 第75回手術手技研究会, 日本語taTMEの手術成績と手技の工夫ポスター発表
- 第75回手術手技研究会, 日本語十二指腸乳頭に近接する表在型腫瘍に対する乳頭損傷予防として膵管ステントを用いた腫瘍切除術式の検討ポスター発表
- 第121回日本外科学会定期学術集会, 日本語低肺機能食道癌患者に対する腹臥位胸腔鏡下食道切除術の安全性シンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語高齢者の胃癌ESD後追加外科切除に関する検討ポスター発表
- 第121回日本外科学会定期学術集会, 日本語当科におけるcStageIV胃癌に対するconversion surgeryの治療成績ポスター発表
- 第121回日本外科学会定期学術集会, 日本語FDG-PET検査によるリンパ節SUVmax値を用いた胃癌リンパ節転移診断の有用性の検討シンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語直腸癌NACRT症例におけるサルコペニアの影響シンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語食道癌におけるcomprehensive complication indexと長期予後の関係シンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語リンパ節転移比率はMinimally invasive esophagectomy（MIE）を施行した食道扁平上皮癌患者の独立予後因子であるシンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての好中球-リンパ球比の意義ポスター発表
- 第121回日本外科学会定期学術集会, 日本語当科における胃腺癌・食道胃接合部腺癌に対する術前化学療法の治療成績ポスター発表
- 第121回日本外科学会定期学術集会, 日本語最新内視鏡システムが腹腔鏡下胃癌手術にもたらすものシンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語大腸癌腹膜播腫モデルにおける PD-L1 耐性とその克服シンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語直腸癌におけるtransperineal minimally invasive APRの有用性：手術成績と定型化についてシンポジウム・ワークショップパネル（公募）
- 第121回日本外科学会定期学術集会, 日本語当科で行っている胸管温存，反回神経非遊離のen-bloc 縦隔郭清シンポジウム・ワークショップパネル（公募）
- 第33回日本内視鏡外科学会総会, 日本語, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, 日本国, 国内会議Computer-based video analysis of device usage in laparoscopic gastrectomy.シンポジウム・ワークショップパネル（公募）
- 第33回日本内視鏡外科学会総会, 日本語, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, 日本国, 国内会議Prone thoracoscopic esophagectomy for patients with low respiratory function口頭発表（一般）
- 第33回日本内視鏡外科学会総会, 日本語, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, 日本国, 国内会議Robot-assisted gastrectomy: short-term outcomes and procedural standardization at a single hospital口頭発表（一般）
- 第33回日本内視鏡外科学会総会, 日本語, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, 日本国, 国内会議Transanal vs. laparoscopic TME for low rectal cancer: clinical outcomes and technical tipsシンポジウム・ワークショップパネル（公募）
- 第33回日本内視鏡外科学会総会, 日本語, 大分大学医学部消化器・小児外科学講座, 横浜/web開催, 日本国, 国内会議Which surgical position is beneficial for thoracoscopic esophagectmoy?-Prone or lateral position-ポスター発表
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議抗血栓療法中の患者に対する胃癌手術の安全性の検討口頭発表（一般）
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議当院におけるロボット支援下幽門側胃切除術の短期治療成績と定型化に向けた取り組み口頭発表（一般）
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議高齢者に対する胃癌ESD後追加手術シンポジウム・ワークショップパネル（公募）
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議高齢進行胃・接合部癌患者に対する術前化学療法の安全性と有用性の検討シンポジウム・ワークショップパネル（公募）
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議術前化学療法を行いpCRを得られた6症例の検討ポスター発表
- 第93回日本胃癌学会総会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学, web開催, 日本国, 国内会議高齢者の胃癌に対する胃切除範囲の予後に及ぼす影響口頭発表（一般）
- 日本消化器病学会近畿支部第114回例会, 2021年02月, 日本語Freshman Session2 胃その他
- 第17回日本消化管学会総会学術集会, 日本語術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての好中球-リンパ球比の意義シンポジウム・ワークショップパネル（公募）
- 第8回日本神経内分泌腫瘍研究会学術集会, 日本語, 横浜市立大学大学院医学研究科 がん総合医科学, web開催, 日本国, 国内会議胃原発混合神経内分泌非神経内分泌腫瘍(MiNEN)の全エクソームシークエンスによる解析口頭発表（一般）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議Standardization of upper mediastinal lymphadenectomy in prone thoracoscopic esophagectomy（腹臥位胸腔鏡下食道切除術における上縦隔郭清の定型化）シンポジウム・ワークショップパネル（公募）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議Comparison of 3D and 4K for laparoscopic gastrectomy for gastric cancer（腹腔鏡下胃癌手術の手術成績に関する内視鏡画像システム（3Ｄvs4Ｋ）のランダム化比較試験）シンポジウム・ワークショップパネル（公募）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議Surgical outcomes and technical tips of transanal total mesorectal excision for low rectal cancer （下部直腸癌に対するtaTMEの手術成績（vs. lap TME）と安全に行うための工夫）シンポジウム・ワークショップパネル（公募）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議Standardization of the robotic esophagectomy based on standardized minimally invasive esophagectomy（胸腔鏡手術との互換性から考えるロボット支援下食道切除術への移行と定型化）シンポジウム・ワークショップパネル（公募）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議高齢食道癌患者に対する胸腔鏡下手術の有用性シンポジウム・ワークショップパネル（公募）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議当院におけるロボット支援下胃切除術の短期治療成績と定型化に向けた取り組み口頭発表（一般）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議胃癌ESD後の追加外科切除に関する検討口頭発表（一般）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議局所進行胃癌に対する術前化学療法著効症例において術後補助化学療法は省略可能か口頭発表（一般）
- 第75回日本消化器外科学会総会, 日本語, 和歌山県立医科大学外科学第2講座, 和歌山/Web開催, 日本国, 国内会議高度進行胃癌に対するConversion surgeryの検討シンポジウム・ワークショップパネル（公募）
- 第74回日本食道学会学術集会, 日本語, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, 日本国, 国内会議Established upper mediastinum lymphadenectomy in prone MIE improves outcomesシンポジウム・ワークショップパネル（公募）
- 第74回日本食道学会学術集会, 日本語, 徳島大学大学院医歯薬学研究部 胸部・内分泌・腫瘍外科学分野, 徳島/Web開催, 日本国, 国内会議Feasibility of lymphadenectomy with thoracic duct preservation in esophageal SCCシンポジウム・ワークショップパネル（公募）
- 第24回バイオ治療法研究会学術集会, 日本語, 福岡大学医学部産科婦人科学講座、福岡がん総合クリニック, web開催, 日本国, 国内会議食道癌術前化学療法の効果予測因子における癌幹細胞マーカーの有用性に関する検討口頭発表（一般）
- 第24回バイオ治療法研究会学術集会, 日本語, 福岡大学医学部産科婦人科学講座、福岡がん総合クリニック, web開催, 日本国, 国内会議腹膜播種における腹腔内MDSCの役割口頭発表（一般）
- 第33回日本外科感染症学会総会学術集会, 日本語, 防衛医科大学校 外科学講座, web開催, 日本国, 国内会議高齢者胃癌切除後の肺炎併発による長期予後への影響の検討シンポジウム・ワークショップパネル（公募）
- 第31回日本消化器癌発生学会総会, 日本語, 大阪市立大学大学院医学研究科 消化器外科, web開催, 日本国, 国内会議直腸癌に対するTa-TME併用直腸切除術の手術手技と手術成績シンポジウム・ワークショップパネル（公募）
- 第31回日本消化器癌発生学会総会, 日本語, 大阪市立大学大学院医学研究科 消化器外科, web開催, 日本国, 国内会議鼠経リンパ節転移陽性直腸癌に対する治療戦略口頭発表（一般）
- 第31回日本消化器癌発生学会総会, 日本語, 大阪市立大学大学院医学研究科 消化器外科, web開催, 日本国, 国内会議大腸癌腹膜播種の病勢に骨髄由来免疫抑制細胞が及ぼす影響とその治療応用シンポジウム・ワークショップパネル（公募）
- 第31回日本消化器癌発生学会総会, 日本語, 大阪市立大学大学院医学研究科 消化器外科, web開催, 日本国, 国内会議放射線治療は、腫瘍内CD8+T細胞の増加とサイトカイン産生を増強し、抗腫瘍効果に寄与するシンポジウム・ワークショップパネル（公募）
- 第31回日本消化器癌発生学会総会, 日本語, 大阪市立大学大学院医学研究科 消化器外科, web開催, 日本国, 国内会議当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討シンポジウム・ワークショップパネル（公募）
- 第50回胃外科・術後障害研究会, 日本語, 帝京大学医学部外科学講座, web開催, 日本国, 国内会議当科における胃癌および食道胃接合部癌に対する術前化学療法の治療成績シンポジウム・ワークショップパネル（公募）
- JDDW2020（第28回日本消化器関連学会週間）, 日本語, 一般社団法人日本消化器関連学会機構, 神戸/web開催, 日本国, 国内会議完全腹腔鏡下幽門側胃切除における点墨による胃切離線決定法の有用性ポスター発表
- JDDW2020（第28回日本消化器関連学会週間）, 日本語, 一般社団法人日本消化器関連学会機構, 神戸/web開催, 日本国, 国内会議食道胃接合部癌Siewert2型におけるリンパ節転移の予後への影響ポスター発表
- JDDW2020（第28回日本消化器関連学会週間）, 日本語, 一般社団法人日本消化器関連学会機構, 神戸/web開催, 日本国, 国内会議低肺機能に対する腹臥位胸腔鏡下食道切除術ポスター発表
- JDDW2020（第28回日本消化器関連学会週間）, 日本語, 一般社団法人日本消化器関連学会機構, 神戸/web開催, 日本国, 国内会議StageⅣ胃癌に対するconversion surgeryポスター発表
- JDDW2020（第28回日本消化器関連学会週間）, 日本語, 一般社団法人日本消化器関連学会機構, 神戸/web開催, 日本国, 国内会議十二指腸乳頭に近接する表在型腫瘍に対する乳頭損傷予防として膵管ステントを用いた腫瘍切除術式の検討ポスター発表
- 第73回日本胸部外科学会定期学術集会, 日本語, 名古屋大学大学院医学系研究科 心臓外科学, web開催, 日本国, 国内会議飽和食塩溶液固定法を用いた腹臥位胸腔鏡下食道切除術のCadaver Surgical Trainingシンポジウム・ワークショップパネル（公募）
- 第79回日本癌学会学術総会, 日本語, 広島大学大学院医系化学研究科 分子病理学, 広島, 日本国, 国内会議放射線治療は新たに浸潤するCD8+T細胞を増強し、腫瘍内CD8+T細胞の増加と抗腫瘍効果に寄与する。ポスター発表
- 第203回近畿外科学会, 日本語, 大阪市立大学大学院医学研究科 消化器外科、乳腺・内分泌外科学, webおよび誌上開催, 日本国, 国内会議Killian-Jamieson 憩室内に発生した食道癌の一例口頭発表（一般）
- 第203回近畿外科学会, 日本語, 大阪市立大学大学院医学研究科 消化器外科、乳腺・内分泌外科学, webおよび誌上開催, 日本国, 国内会議Ta-TME併用による腹会陰式直腸切断術の手術手技と手術成績口頭発表（一般）
- 第33回近畿内視鏡外科研究会, 日本語, 大阪市立大学大学院 医学研究科 消化器外科学 乳腺・内分泌外科学, web開催, 日本国, 国内会議低肺機能食道患者に対する腹臥位胸腔鏡下食道切除術口頭発表（一般）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道癌手術における術前の歯牙欠損と術後の予後との関係ポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議胸部食道癌術後にsevereな体重減少を認める症例は予後不良であり、周術期に短期的な経腸栄養を行っても改善しないポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議間葉系幹細胞由来のCXCL16は胃癌細胞においてSTAT3経路を介してRor1の発現を誘導し増殖と遊走を促進するポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道亜全摘術の再建経路選択におけるICG蛍光観察法の有用性ポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議オープンソースの物体検出アルゴリズムを用いた腹腔鏡下胃癌手術ビデオにおける手術器具自動認識システムの開発と利用シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道癌手術における術後合併症予測因子及び長期予後予測因子としてのSurgical Apgar Scoreの有用性ポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道胃接合部癌 Siewert2 型におけるリンパ節転移の予後への影響シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議当院における腹腔鏡下胃全摘術の安全性と有用性ポスター発表
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術～腫瘍局在に応じた外科手技の工夫と治療成績～シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議術後腹膜炎が転移を促進させる-マウス腹膜炎モデルにおける肺転移への影響シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議「外側先行剥離」による新しいTaTME手技シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議ロボット支援手術における上縦隔郭清手技とその可能性シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道癌に対する胸腔鏡下手術の治療成績シンポジウム・ワークショップパネル（公募）
- 第120回日本外科学会定期学術集会, 日本語, 慶応義塾大学医学部外科学教室, web開催, 日本国, 国内会議食道胃接合部腺癌に対する術前補助化学療法の検討ポスター発表
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議Preoperative endoscopic tattooing using India ink for totally laparoscopic distal gastrectomy口頭発表（一般）
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議Conversion surgery following chemotherapy for Stage Ⅳ gastric cancerポスター発表
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議リンパ節転移を伴う早期胃癌の予後に関する検討口頭発表（一般）
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議抗血栓療法中患者に対する胃切除術における周術期抗血栓療法の検討ポスター発表
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議高齢者局所進行胃癌に対する術前化学療法の有効性と安全性口頭発表（一般）
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議SiewertⅡ型食道胃接合部癌に対する偽His角・fornix形成食道胃管再建ポスター発表
- 第92回日本胃癌学会総会, 日本語, 国立がん研究センター 先端医療開発センター, web開催, 日本国, 国内会議食道胃接合部腺癌に対する術前補助化学療法の有用性口頭発表（一般）
- 第41回癌免疫外科研究会, 日本語, 大阪大学大学院医学系研究科 臨床腫瘍免疫学, 大阪, 日本国, 国内会議腹膜播種の病勢に腹腔内骨髄由来抑制細胞が及ぼす影響と、治療標的としての可能性口頭発表（一般）
- 第41回癌免疫外科研究会, 日本語, 大阪大学大学院医学系研究科 臨床腫瘍免疫学, 大阪, 日本国, 国内会議NKT細胞ワクチンベクターの抗原特異的T細胞の活性化口頭発表（一般）
- AACR Annual Meeting 2020, 英語, web開催, 国際会議Radiationtherapy for tumors enhances newly-infiltrating CD8⁺T cells and contributes to the increase of intratumor CD8⁺T cells and anti-tumor effects.ポスター発表
- 15th ANNUAL ACADEMIC SURGICAL CONGRESS, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Florida, アメリカ合衆国, 国際会議Influence of Lymphatic Metastasis on the Recurrence of Adenocarcinoma of the Esophagogastric Junction口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議ミラーイメージの克服についての工夫と検討、左右差について口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議完全腹腔鏡下幽門側胃切除術における点墨による病変マーキングの有用性口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議ASA class 3,4 のhigh risk 大腸癌患者における腹腔鏡手術の有用性口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議低肺機能に対する腹臥位胸腔鏡下食道切除術シンポジウム・ワークショップパネル（公募）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議腹腔鏡下噴門側胃切除後の食道胃管再建に関する検討口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議評価型外科縫合シミュレーターを活用した研修医・専攻医に対する腹腔鏡縫合結紮トレーニング口頭発表（一般）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議ロボット支援Minimally invasive esophagectomy の可能性シンポジウム・ワークショップパネル（公募）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議腹腔鏡下結腸右半切除D3郭清における頭側アプローチの有用性シンポジウム・ワークショップパネル（公募）
- 第32回日本内視鏡外科学会総会, 日本語, 東海大学医学部消化器外科, 横浜, 日本国, 国内会議外側先行剥離によるTa-TME の標準化シンポジウム・ワークショップパネル（公募）
- 7th FACO Academic Conference, 英語, Chinese Society of Clinical Oncology, Shanghai, 中華人民共和国, 国際会議When should esophagectomy be performed to non-curative superficial esophageal cancer after endoscopic resection?ポスター発表
- 7th FACO Academic Conference, 英語, Chinese Society of Clinical Oncology, Shanghai, 中華人民共和国, 国際会議Safety of preoperative chemotherapy for elderly gastric cancer patientsポスター発表
- 第81回日本臨床外科学会総会, 日本語, 高知大学外科学講座外科１, 高知, 日本国, 国内会議その他のヘルニア2その他
- 第30回日本消化器癌発生学会総会, 日本語, 一般社団法人 日本消化器癌発生学会, 横浜, 日本国, 国内会議食道扁平上皮癌術前化学療法によるPD-L1発現とCD8陽性腫瘍浸潤リンパ球の誘導シンポジウム・ワークショップパネル（公募）
- 第30回日本消化器癌発生学会総会, 日本語, 一般社団法人 日本消化器癌発生学会, 横浜, 日本国, 国内会議腹膜播種における腹腔内腫瘍免疫微小環境の解析シンポジウム・ワークショップパネル（公募）
- 第49回胃外科・術後障害研究会, 日本語, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, 国内会議完全腹腔鏡下幽門側胃切除術における点墨による病変マーキングの有用性ポスター発表
- 第49回胃外科・術後障害研究会, 日本語, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, 日本国, 国内会議早期胃癌に対するESD後追加外科切除例の検討シンポジウム・ワークショップパネル（公募）
- 第49回胃外科・術後障害研究会, 日本語, 鹿児島大学大学院 消化器・乳腺甲状腺外科学, 鹿児島, 日本国, 国内会議食道胃接合部に近接するGISTに対する噴門機能を温存した腹腔鏡下局所切除の安全性に関する検討シンポジウム・ワークショップパネル（公募）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議歯牙欠損は食道癌術後の予後を悪化させる口頭発表（一般）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議食道扁平上皮癌術前化学療法によるPD-L1発現とCD8陽性腫瘍浸潤リンパ球の誘導口頭発表（一般）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績シンポジウム・ワークショップパネル（公募）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議局所進行胃癌に対するneoadjuvant cheterapyとしてのSOX療法の安全性ポスター発表
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議抗血栓薬内服患者に対する胃切除術における周術期抗血栓療法の検討シンポジウム・ワークショップパネル（公募）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議食道癌手術治療に対するエノキサパリンによる静脈血栓塞栓症予防ポスター発表
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議鼠径リンパ節転移を伴う直腸癌に対する術前化学放射線療法口頭発表（一般）
- 第57回日本癌治療学会学術集会, 日本語, 岐阜大学大学院医学系研究科 脳腫瘍制御学講座 腫瘍外科学分野, 福岡, 日本国, 国内会議StageⅣ胃癌に対するconversion surgeryの検討口頭発表（一般）
- 日本消化器病学会近畿支部第111回例会, 日本語, 神戸大学大学院医学研究科外科学講座食道胃腸外科学, 大阪, 日本国, 国内会議腹腔鏡下に切除し得た副腎腫瘤を合併した家族性大腸ポリポーシスの１例口頭発表（一般）
- 日本消化器病学会近畿支部第111回例会, 日本語, 神戸大学大学院医学研究科外科学講座食道胃腸外科学, 大阪, 日本国, 国内会議胸腔鏡下核出術を施行した食道神経鞘腫の一例口頭発表（一般）
- 第202回近畿外科学会, 日本語, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, 日本国, 国内会議完全内臓逆位を伴うＳ状結腸癌に対して腹腔鏡下Ｓ状結腸切除を施行した一例口頭発表（一般）
- 第202回近畿外科学会, 日本語, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, 日本国, 国内会議炎症による反復性幽門狭窄をきたした胃異所性膵に対して腹腔鏡下幽門側胃切除術を行った1例口頭発表（一般）
- 第202回近畿外科学会, 日本語, 大阪大学大学院医学系研究科 外科学講座 消化器外科学, 大阪, 日本国, 国内会議大動脈十二指腸瘻の治療経験口頭発表（一般）
- 日本・モンゴル国際消化器がんシンポジウム, 英語, Ulaanbaatar, モンゴル国, 国際会議Safety and effectiveness of laparoscopic colorectomy for elderly patients: A propensity-score matching analysis口頭発表（一般）
- 日本・モンゴル国際消化器がんシンポジウム, 英語, Ulaanbaatar, モンゴル国, 国際会議Transanal total mesorectal excision (ta TME) for rectal cancer by two-surgeon team.口頭発表（一般）
- 日本・モンゴル国際消化器がんシンポジウム, 英語, Ulaanbaatar, モンゴル国, 国際会議Laparoscopic surgery for gastric GIST口頭発表（一般）
- 第91回大腸癌研究会, 日本語, がん・感染症センター 都立駒込病院 外科, 東京, 日本国, 国際会議当院における大腸NETの手術治療成績ポスター発表
- 第26回外科侵襲とサイトカイン研究会, 日本語, 神戸大学大学院医学研究科外科系講座 災害・救急医学分野, 神戸, 日本国, 国内会議術後腹膜炎が肺転移の予後に及ぼす影響とその免疫学的検討シンポジウム・ワークショップパネル（公募）
- 第44回日本外科系連合学会学術集会, 日本語, 金沢医科大学 一般・消化器外科学, 金沢, 日本国, 国内会議高齢者の胃癌切除におけるCONUT scoreによるフレイル判定の有用性シンポジウム・ワークショップパネル（公募）
- IGCC 2019 第13回国際胃癌学会議（13th INTERNATIONAL GASTRIC CANCER CONGRESS), 英語, Prague, チェコ共和国, 国際会議Impact of Lymphatic Metastasis for the Recurrence of Adenocarcinoma of the Esophagogastric Junctionポスター発表
- IGCC 2019 第13回国際胃癌学会議（13th INTERNATIONAL GASTRIC CANCER CONGRESS), 英語, Prague, チェコ共和国, 国際会議The long-term impact of postoperative pneumonia after curative gastrectomy for elderly gastric cancer patientsポスター発表
- 第117回日本外科学会定期学術集会, 2017年04月, 日本語, 国内会議食道胃接合部癌Siewert II型に対する下縦隔立体構造を意識した腹腔鏡下リンパ節郭清と逆流防止を意識した偽His角・fornix形成を伴う食道胃管吻合法ポスター発表
- 第87回日本胃癌学会総会, 2016年03月, 日本語, 国内会議食道胃接合部腺癌におけるリンパ節転移分布および再発形式からみた縦隔リンパ節郭清範囲の検討口頭発表（一般）
- 第48回胃病態機能研究会, 2016年02月, 日本語, 国内会議当院における食道胃接合部癌に対する治療戦略口頭発表（一般）
- 第73回日本癌学会学術集会, 2014年09月, 英語, 国内会議食道癌における腫瘍関連マクロファージや腫瘍細胞から分泌される増殖分化因子GDF15の臨床病理学的検討ポスター発表
- 第68回日本消化器外科学会総会, 2013年07月, 日本語, 国内会議食道胃接合部癌に対する外科治療の検討シンポジウム・ワークショップパネル（公募）
- 第113回日本外科学会, 2013年04月, 日本語, 国内会議食道癌に対する腹腔鏡補助下胃管再建術の治療成績口頭発表（一般）