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小林 隆医学部附属病院 消化器内科助教
研究活動情報
■ 受賞- 2018年09月 日本分子腫瘍マーカー研究会, 奨励賞, 血中アポリポ蛋白A2アイソフォーム測定による膵がん検診の可能性
- 2013年05月 American Gastroenterological Association, Poster of distinction, Poster presentation国際学会・会議・シンポジウム等の賞
- 2025年05月, Pancreatology研究論文（学術雑誌）
- OBJECTIVES: Covered self-expandable metal stents are commonly used for unresectable malignant distal biliary obstruction. Partially covered self-expandable metal stents have uncovered sections at both ends; however, their anti-migration effect remains unclear. The objective of this study was to evaluate that effect by comparing such stents with fully covered self-expandable metal stents for patients with unresectable malignant distal biliary obstruction. METHODS: This was a multicenter, retrospective comparative study of partially covered stents with fully covered stents for unresectable malignant distal biliary obstruction. Stent migration, recurrent biliary obstruction, and the time to recurrent biliary obstruction were compared between them. RESULTS: Thirty-nine patients with partially covered stents were included and compared with 42 patients with fully covered stents. The partially covered group had a significantly lower stent migration rate (3% vs. 36%; p < 0.001). The recurrent biliary obstruction rate was significantly lower in the partially covered group (21% vs. 43%; p = 0.036). The non-recurrent biliary obstruction rate at 6 months was 90% and 68% in the partially and fully covered groups, respectively. The time to recurrent biliary obstruction was significantly longer in the partially covered group (Gray's test, p = 0.016). Only partially covered stent placement was significantly associated with a lower risk of stent migration (subdistribution hazard ratio = 0.077; 95% confidence interval = 0.01-0.60; p = 0.014) in the multivariable analysis. CONCLUSIONS: The anti-migration effect of partially covered self-expandable metal stents was associated with a reduced recurrence of biliary obstruction and prolonged time to such obstruction.2025年04月, DEN open, 5(1) (1), e70100, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Focal pancreatic parenchymal atrophy (FPPA) and upstream pancreatic atrophy (UPA) may indicate the presence of early pancreatic cancer. In early pancreatic cancer, the tumor occasionally spreads laterally along the main pancreatic duct, presenting challenges in determining the extent of surgical resection. This study aimed to investigate the association of pancreatic atrophy pattern and intraductal cancer extension. METHODS: Thirty-two patients with early-stage pancreatic cancer who underwent surgery at five participating centers were enrolled. Pancreatic atrophy was defined as the narrowing of parenchyma compared to the surrounding parenchyma and was classified as either FPPA (partial atrophy surrounding the pancreatic duct stenosis) or UPA (global atrophy caudal to the site of duct stenosis). Intraductal cancer extension was defined as an extension exceeding 10 mm. RESULTS: Preoperative computed tomography revealed FPPA, UPA, and no parenchymal atrophy in 13, 13, and 6 patients. Cases with FPPA or UPA showed significantly longer cancer extensions than those without atrophy (P = 0.005 and P = 0.03, respectively). Intraductal cancer extension was present in all but one case of FPPA. 69% (9/13) of the cases with UPA showed intraductal cancer extension, whereas cases without atrophy showed no intraductal cancer extension. Importantly, two patients with FPPA or UPA showed positive resection margins during surgery and three patients with FPPA or UPA showed recurrence in the remnant pancreas. CONCLUSIONS: The presence of FPPA and UPA indicates lateral cancer extension in early-stage pancreatic cancer. Preoperative assessment of the pancreatic parenchyma may provide valuable insights for determining the extent of surgical resection.2024年12月, Journal of gastroenterology, 59(12) (12), 1133 - 1142, 英語, 国内誌研究論文（学術雑誌）
- (一社)日本癌学会, 2024年09月, 日本癌学会総会記事, 83回, J - 2054, 英語膵癌の腫瘍免疫・予後に関連する腫瘍内細菌叢の探索(Association of Intratumoral Microbiome with Tumor Immunity and Prognosis in Human Pancreatic Cancer)
- Background Pancreatic duct (PD) disruption can occasionally be attributed to pancreatic cancer. Therapeutic interventions for PD disruption due to pancreatic cancer and their influence on pancreatic cancer prognosis remain unclear. This study investigated the therapeutic modalities and prognostic implications of PD disruption in pancreatic cancer. Methods This retrospective study included 15 patients with PD disruption concomitant with pancreatic cancer between April 2011 and March 2023. As an endoscopic intervention for PD disruption, endoscopic pancreatic stenting (EPS) or endoscopic ultrasonography-guided pancreatic fluid collection drainage (EUS-PFD) was performed. Technical success was defined as stent placement and clinical success was defined as an improvement in PD disruption. Results Of the 15 cases of PD disruption, two involved only pancreatic juice leakage without symptoms, four involved pancreatic pseudocyst (PPC) without infection, and nine involved PPC with infection. Four patients underwent EPS, nine underwent EUS-PFD, and two underwent lumen-apposing metal stent placement. All patients achieved both technical and clinical success without complications. The clinical stage of pancreatic cancer ranged from carcinoma in situ to the metastatic phase. For the treatment of pancreatic cancer, five patients underwent surgical resection, and eight underwent chemotherapy. There was no obvious recurrence of peritoneal sowing. The median overall survival from the diagnosis of pancreatic cancer in the resected and non-resected cases was 74 and 9.6 months, respectively. Conclusion Endoscopic intervention was effective in all cases of PD disruption due to pancreatic cancer. Furthermore, even in cases of pancreatic cancer after PD disruption, survival rates were similar to those in cases without PD disruption and were achieved through surgical resection or chemotherapy.2024年08月, Cureus, 16(8) (8), e67482, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本膵臓学会, 2024年07月, 膵臓, 39(3) (3), A199 - A199, 日本語
- (一社)日本膵臓学会, 2024年07月, 膵臓, 39(3) (3), A206 - A206, 日本語
- (一社)日本膵臓学会, 2024年07月, 膵臓, 39(3) (3), A336 - A336, 日本語
- BACKGROUND: Focal parenchymal atrophy and main pancreatic duct (MPD) dilatation have been identified as early signs of pancreatic ductal adenocarcinoma. However, limited evidence exists regarding their temporal progression due to previous study limitations with restricted case numbers. OBJECTIVE: To ascertain a more precise frequency assessment of suspicious pancreatic ductal adenocarcinoma findings as well as delineate the temporal progression of them. METHODS: A multicenter retrospective study was conducted on patients diagnosed with pancreatic ductal adenocarcinoma between 2015 and 2021. We included patients who had undergone at least one computed tomography (CT) scan ≥6 months before diagnosing pancreatic ductal adenocarcinoma. The temporal progression of suspicious pancreatic ductal adenocarcinoma findings on CT was investigated. RESULTS: Out of 1832 patients diagnosed with pancreatic ductal adenocarcinoma, 320 had a previous CT before their diagnosis. Suspicious pancreatic ductal adenocarcinoma findings were detected in 153 cases (47.8%), with focal parenchymal atrophy (26.6%) being the most common followed by MPD dilatation (11.3%). Focal parenchymal atrophy was the earliest detectable sign among all suspicious findings and became visible on average 2.7 years before diagnosis, and the next most common, MPD dilatation, 1.1 years before diagnosis. Other findings, such as retention cysts, were less frequent and appeared around 1 year before diagnosis. Focal parenchymal atrophy followed by MPD dilatation was observed in 10 patients but not in reverse order. Focal parenchymal atrophy was more frequently detected in the pancreatic body/tail. No significant relationship was found between the pathological pancreatic ductal adenocarcinoma differentiation or tumor stage and the time course of the CT findings. All cases of focal parenchymal atrophy progressed just prior to diagnosis, and the atrophic area was occupied by tumor at diagnosis. Main pancreatic duct dilatation continued to progress until diagnosis. CONCLUSION: This large-scale study revealed that the temporal progression of focal parenchymal atrophy is the earliest detectable sign indicating pancreatic ductal adenocarcinoma. These results provide crucial insights for early pancreatic ductal adenocarcinoma detection.2024年03月, United European gastroenterology journal, 英語, 国際誌研究論文（学術雑誌）
- (一財)日本消化器病学会, 2024年03月, 日本消化器病学会雑誌, 121(臨増総会) (臨増総会), A81 - A81, 日本語
- (一財)日本消化器病学会, 2024年03月, 日本消化器病学会雑誌, 121(臨増総会) (臨増総会), A187 - A187, 日本語
- (一財)日本消化器病学会, 2024年03月, 日本消化器病学会雑誌, 121(臨増総会) (臨増総会), A431 - A431, 日本語
- 2024年02月, Journal of gastroenterology
Background
Immune checkpoint inhibitor-related pancreatic injury (ICI-PI) is a rare occurrence, which has not been reported in detail. We conducted a retrospective multicenter study to determine the clinical characteristics, risk factors, and treatment of ICI-PI.Methods
We reviewed the medical records of patients who received ICIs for malignant tumors between April 2014 and April 2019 at 16 participating hospitals. Patients with elevated pancreatic enzymes or pancreatitis were identified and classified using the Common terminology Criteria for Adverse Events (CTCAE) ver.5.0). The number of patients with pancreatic enzyme elevation was determined and those with pancreatic enzyme elevation of ≥ grade 3 according to CTCAE ver.5.0, or pancreatitis underwent detailed analysis for ICI-PI.Results
The study enrolled 1069 patients. Nineteen patients (1.8%) had ICI-PI, 5 (0.5%) of whom also had pancreatitis. Four patients had mild pancreatitis, whereas 1 patient had severe pancreatitis, culminating in death. Steroid therapy was administered to 7 of 19 patients, which led to ICI-PI improvement in 5 patients. On the other hand, ICI-PI improved in 9 of 12 patients who were not administered steroid therapy. Six of the 14 patients with ICI-PI improvement were rechallenged with ICI, and ICI-PI relapse occurred in only 1 patient (16.7%), which improved with ICI discontinuation and steroid therapy.Conclusions
ICI-PI is a rare occurrence, with a low incidence of pancreatitis, which followed a very serious course in one patient. Although the benefit of steroid therapy for ICI-PI is unclear, ICI rechallenge is acceptable after improvement of ICI-PI without pancreatitis.研究論文（学術雑誌） - BACKGROUND: The impact of extended steroid administration on patients with autoimmune pancreatitis after a 3-year maintenance period remains poorly understood. This study analyzed the advantage and disadvantage of continuing steroid therapy beyond 3 years. METHODS: In this retrospective multicenter study across 17 institutions, patients who successfully completed 3 years of maintenance therapy without experiencing relapse were categorized into two groups: the maintenance therapy discontinuation group, who discontinued steroid therapy after the initial 3-year period, and maintenance therapy continuation group, who continued steroid therapy beyond 3 years. The cumulative relapse rate after 3 years of maintenance therapy was the primary outcome. Relapse predictors were compared using the Gray test for cumulative relapse incidence by specific factor. RESULTS: Of 211 patients, 105 experienced no relapse during the 3-year maintenance therapy and were divided into two groups: 69 in the maintenance therapy discontinuation group and 36 in the maintenance therapy continuation group. The relapse rate was lower in the maintenance therapy continuation group than in the maintenance therapy discontinuation group (P = 0.035). Predictors of relapse after 3 years included cessation of maintenance therapy (hazard ratio [HR] = 3.76; 95 % confidence interval [CI] = 1.07-13.3, P = 0.040) and renal involvement (HR = 2.88; 95 % CI = 1.04-7.99, P = 0.042). The maintenance therapy continuation group showed a significantly higher prevalence of macrovascular complications, compared with the maintenance therapy discontinuation group (P = 0.005). CONCLUSIONS: Cessation of steroid maintenance therapy and renal involvement were predictors of relapse after 3 years of maintenance therapy. However, the long-term use of steroids may increase the risk of macrovascular complications.2024年01月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Recent evidence suggests that the presence of microbiome within human pancreatic ductal adenocarcinoma (PDAC) tissue potentially influences cancer progression and prognosis. However, the significance of tumor-resident microbiome remains unclear. We aimed to elucidate the impact of intratumoral bacteria on the pathophysiology and prognosis of human PDAC. METHODS: The presence of intratumoral bacteria was assessed in 162 surgically resected PDACs using quantitative polymerase chain reaction (qPCR) and in situ hybridization (ISH) targeting 16S rRNA. The intratumoral microbiome was explored by 16S metagenome sequencing using DNA extracted from formalin-fixed paraffin-embedded tissues. The profile of intratumoral bacteria was compared with clinical information, pathological findings including tumor-infiltrating T cells, tumor-associated macrophage, fibrosis, and alterations in four main driver genes (KRAS, TP53, CDKN2A/p16, SMAD4) in tumor genomes. RESULTS: The presence of intratumoral bacteria was confirmed in 52 tumors (32%) using both qPCR and ISH. The 16S metagenome sequencing revealed characteristic bacterial profiles within these tumors, including phyla such as Proteobacteria and Firmicutes. Comparison of bacterial profiles between cases with good and poor prognosis revealed a significant positive correlation between a shorter survival time and the presence of anaerobic bacteria such as Bacteroides, Lactobacillus, and Peptoniphilus. The abundance of these bacteria was correlated with a decrease in the number of tumor-infiltrating T cells positive for CD4, CD8, and CD45RO. CONCLUSIONS: Intratumoral infection of anaerobic bacteria such as Bacteroides, Lactobacillus, and Peptoniphilus is correlated with the suppressed anti-PDAC immunity and poor prognosis.2024年01月, Journal of gastroenterology, 英語, 国内誌研究論文（学術雑誌）
- 日本消化器病学会-近畿支部, 2024年01月, 日本消化器病学会近畿支部例会プログラム・抄録集, 120回, 70 - 70, 日本語
- 2024年01月, Journal of medical ultrasonics (2001), 51(1) (1), 143 - 144, 英語, 国内誌研究論文（学術雑誌）
- 日本消化器内視鏡学会-近畿支部, 2023年11月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 111回, 109 - 109, 日本語経口胆道鏡が有用であった胆嚢管癌の一例
- OBJECTIVES: Aging is associated with a high prevalence of pancreatic cysts and intraductal papillary mucinous neoplasms (IPMNs). Metabolic syndrome (MS) may increase the risk of neoplasms, including those that develop in the pancreas. However, the influence of factors associated with MS on the development of IPMN remains unclear. METHODS: A total of 9363 patients who underwent abdominal ultrasound examinations between April 2012 and May 2013 were included in this study. Multivariate logistic regression analysis was performed to identify factors associated with the presence of IPMN by age. RESULTS: Pancreatic cysts were detected in 198 of 9363 patients, of whom 129 were found to have IPMNs. The presence of IPMN significantly correlated with age (10-year increments; odds ratio, 2.73; 95% CI, 2.28-3.29; P < 0.001). High body mass index, history of smoking, hyperlipidemia, hypertension, and MS were associated with a higher prevalence of IPMN with advancing age. In multivariate analysis, the presence of IPMN was more frequent in elderly patients with MS (odds ratio, 3.14; 95% CI, 3.14-6.72; P = 0.003). CONCLUSIONS: The present study suggests that the incidence of IPMN increases with age and is accelerated in the presence of MS.2023年10月, Pancreas, 英語, 国際誌研究論文（学術雑誌）
- Intraductal papillary mucinous neoplasm (IPMN) is a premalignant lesion of the pancreas that can occasionally manifest as recurrent acute pancreatitis. In this report, we discuss a unique case of a 49-year-old woman who presented with recurrent acute pancreatitis of an unknown cause for several years. Workup using peroral pancreatoscopy eventually showed main-duct IPMN with high-grade dysplasia as the obscure cause of recurrent acute pancreatitis. This case report highlights the clinical course of main-duct IPMN and the evolving role of peroral pancreatoscopy in patients with recurrent acute pancreatitis.2023年10月, ACG case reports journal, 10(10) (10), e01165, 英語, 国際誌
- (一社)日本癌学会, 2023年09月, 日本癌学会総会記事, 82回, 1929 - 1929, 英語膵癌の腫瘍間質膠原線維量と分子病理学的特徴、腫瘍免疫、予後との関連性(Association of Tumor-Stromal Collagen Quantity in PDAC with Molecular Pathology, Tumor Immunity, and Prognosis)
- Pancreatic cancer primarily arises from microscopic precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and acinar-to-ductal metaplasia (ADM). However, no established method exists for predicting pancreatic precancerous conditions. Endoscopic ultrasonography (EUS) can detect changes in pancreatic parenchymal histology, including fibrosis. This study aimed to elucidate the relationship between pancreatic parenchymal EUS findings and microscopic precancerous lesions. We retrospectively analyzed 114 patients with pancreatobiliary tumors resected between 2010 and 2020 and evaluated the association between pancreatic parenchymal EUS findings and the number of PanIN, ADM, and pancreatic duct gland (PDG). Of the 114 patients, 33 (29.0%), 55 (48.2%), and 26 (22.8%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. Multivariate analyses revealed that abnormal EUS findings were significantly associated with the frequency of PanIN (hyperechoic foci/stranding without lobularity: OR [95% CI] = 2.7 [1.0-7.3], with lobularity: 6.5 [1.9-22.5], Ptrend = 0.01) and ADM (hyperechoic foci/stranding without lobularity: 3.1 [1.1-8.2], with lobularity: 9.7 [2.6-36.3], Ptrend = 0.003) but not with PDG (hyperechoic foci/stranding without lobularity: 2.2 [0.8-5.8], with lobularity: 3.2 [1.0-10.2], Ptrend = 0.12). We observed a trend toward a significantly higher number of precancerous lesions in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. Pancreatic parenchymal EUS findings were associated with the increased frequency of PanIN and ADM. Lobularity may help predict the increased number of precancerous lesions.2023年07月, Scientific reports, 13(1) (1), 12052 - 12052, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Abundant collagen deposition is a hallmark of pancreatic ductal adenocarcinomas (PDACs). This study clarified the interactive relationship between tumor-stromal collagen, molecular and immune characteristics, and tumor pr ogression in human PDAC. METHODS: We performed a comprehensive examination using an integrative molecular pathological epidemiology database on 169 cases with resected PDAC . The amount of tumor-stromal collagen was quantified through digital imaging analysis for Elastica van Gieson-stained whole-section tumor slides. We analyzed the association of tumor-stromal collagen with gene alterations (KRAS, TP53, CDKN2A/p16, and SMAD4), immune parameters (CD4+ tumor-infiltrating lymphocytes [TILs], CD8+ TILs, FOXP3+ TILs, and tertiary lymphoid structures), and patient prognosis. RESULTS: Low amounts of tumor-stromal collagen were associated with poor differentiation (multivariable OR = 3.82, 95%CI = 1.41-12.2, P = 0.008) and CDKN2A/p16 alteration (OR [95%CI] = 2.06 [1.08-4.02], P = 0.03). Tumors with low collagen levels had shorter overall survival (HR [95%CI] = 2.38 [1.59-3.56], P < 0.0001). In the S-1 and gemcitabine (GEM) treatment groups, low tumor-stromal collagen was linked to poor prognosis of patients with PDAC (S-1 group: multivariable HR [95%CI] = 2.76 [1.36-5.79], P = 0.005; GEM group: multivariate HR [95%CI] = 2.91 [1.34-6.71], P = 0.007). Additionally, low amounts of tumor-stromal collagen were also linked to low levels of CD4+ TILs (P = 0.046), CD8+ TILs (P = 0.09), and tertiary lymphoid structures (P = 0.001). CONCLUSIONS: Tumor-stromal collagen deposition may play a crucial role in modulating tumor-immune microenvironment and determining response to adjuvant chemotherapy and patient survival outcomes.2023年07月, Journal of gastroenterology, 英語, 国内誌研究論文（学術雑誌）
- 2023年07月, Clinical endoscopy
Background/aims
Endoscopic self-expandable metal stent (SEMS) placement is currently the standard technique for treating unresectable malignant distal biliary obstructions (MDBO). Therefore, covered SEMS with longer stent patency and fewer migrations are required. This study aimed to assess the clinical performance of a novel, fully covered SEMS for unresectable MDBO.Methods
This was a multicenter single-arm prospective study. The primary outcome was a non-obstruction rate at 6 months. The secondary outcomes were overall survival (OS), recurrent biliary obstruction (RBO), time to RBO (TRBO), technical and clinical success, and adverse events.Results
A total of 73 patients were enrolled in this study. The non-obstruction rate at 6 months was 61%. The median OS and TRBO were 233 and 216 days, respectively. The technical and clinical success rates were 100% and 97%, respectively. Furthermore, the rate of occurrence of RBO and adverse events was 49% and 21%, respectively. The length of bile duct stenosis (<2.2 cm) was the only significant risk factor for stent migration.Conclusions
The non-obstruction rate of a novel fully covered SEMS for MDBO is comparable to that reported earlier but shorter than expected. Short bile duct stenosis is a significant risk factor for stent migration.研究論文（学術雑誌） - (一社)日本膵臓学会, 2023年07月, 膵臓, 38(3) (3), A369 - A369, 日本語
- 2023年06月, Annals of surgical oncology, 英語, 国際誌研究論文（学術雑誌）
- A 75-year-old Japanese woman visited a hospital with a stomachache. The patient was diagnosed with localized mild acute pancreatitis. Blood tests revealed elevated serum IgG4 levels. Contrast-enhanced computed tomography showed a hypovascular mass, 3 cm in size, in the pancreatic body with dilation of the upstream duct. Additionally, it showed another tumorous lesion of 10 mm in size in the anterior wall of the stomach, and endoscopic examination confirmed a submucosal tumor (SMT) sized 10 mm in the anterior wall of the stomach. Endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB) of the pancreas revealed an adenocarcinoma concomitant with marked IgG4-positive cell infiltration. Hence, distal pancreatectomy with local gastrectomy was performed, and the final diagnosis was concluded as pancreatic ductal adenocarcinoma (PDAC) complicated by IgG4-related diseases (IgG4-RD) in the pancreas and stomach. IgG4-RD of the digestive tract is exceedingly rare. The correlation between PDAC and autoimmune pancreatitis or malignancy and IgG4-RD is controversial. However, the clinical course and histopathological examination, in this case, provide valuable suggestive findings for further discussion.2023年05月, Clinical journal of gastroenterology, 英語, 国内誌研究論文（学術雑誌）
- BACKGROUND: Sarcopenia, defined as a loss of skeletal muscle mass and quality, is found in 30-65% of patients with pancreatic ductal adenocarcinoma (PDAC) at diagnosis, and is a poor prognostic factor. However, it is yet to be evaluated why sarcopenia is associated with poor prognosis. Therefore, this study elucidated the tumor characteristics of PDAC with sarcopenia, including driver gene alterations and tumor microenvironment. PATIENTS AND METHODS: We retrospectively analyzed 162 patients with PDAC who underwent pancreatic surgery between 2008 and 2017. We defined sarcopenia by measuring the skeletal muscle mass at the L3 level using preoperative computed tomography images and evaluated driver gene alteration (KRAS, TP53, CDKN2A/p16, and SMAD4) and tumor immune (CD4+, CD8+, and FOXP3+) and fibrosis status (stromal collagen). RESULTS: In localized-stage PDAC (stage ≤ IIa), overall survival (OS) and recurrence-free survival were significantly shorter in the sarcopenia group than in the non-sarcopenia group (2-year OS 89.7% versus 59.1%, P = 0.03; 2-year RFS 74.9% versus 50.0%, P = 0.02). Multivariate analysis revealed that sarcopenia was an independent poor prognostic factor in localized-stage PDAC. Additionally, tumor-infiltrating CD8+ T cells in the sarcopenia group were significantly less than in the non-sarcopenia group (P = 0.02). However, no difference was observed in driver gene alteration and fib.rotic status. These findings were not observed in advanced-stage PDAC (stage ≥ IIb). CONCLUSIONS: Sarcopenia was associated with a worse prognosis and decreased tumor-infiltrating CD8+ T cells in localized-stage PDAC. Sarcopenia may worsen a patient's prognosis by suppressing local tumor immunity.2023年05月, Annals of surgical oncology, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Tertiary lymphoid structure (TLS) reflects an intense immune response against cancer, which correlates with favorable patient survival. However, the association of TLS with tumor-infiltrating lymphocytes (TILs) and clinical outcomes has not been investigated comprehensively in pancreatic ductal adenocarcinoma (PDAC). METHODS: We utilized an integrative molecular pathological epidemiology database on 162 cases with resected PDAC, and examined TLS in relation to levels of TILs, patient survival, and treatment response. In whole-section slides, we assessed the formation of TLS and conducted immunohistochemistry for tumor-infiltrating T cells (CD4, CD8, CD45RO, and FOXP3). As confounding factors, we assessed alterations of four main driver genes (KRAS, TP53, CDKN2A [p16], and SMAD4) using next-generation sequencing and immunohistochemistry, and tumor CD274 (PD-L1) expression assessed by immunohistochemistry. RESULTS: TLSs were found in 112 patients with PDAC (69.1%). TLS was associated with high levels of CD4+ TILs (multivariable odds ratio [OR], 3.50; 95% confidence interval [CI] 1.65-7.80; P = 0.0002), CD8+ TILs (multivariable OR, 11.0; 95% CI 4.57-29.7, P < 0.0001) and CD45RO+ TILs (multivariable OR, 2.65; 95% CI 1.25-5.80, P = 0.01), but not with levels of FOXP3+ TILs. TLS was associated with longer pancreatic cancer-specific survival (multivariable hazard ratio, 0.37; 95% CI 0.25-0.56, P < 0.0001) and favorable outcomes of adjuvant S-1-treatment. TLS was not associated with driver gene alterations but tumor CD274 negative expression. CONCLUSIONS: Our comprehensive data supports the surrogacy of TLS for vigorous anti-tumor immune response characterized by high levels of helper and cytotoxic T cells and their prognostic role.2023年01月, Journal of gastroenterology, 英語, 国内誌研究論文（学術雑誌）
- When the etiology of pancreatitis cannot be determined despite sufficient investigation, recurrence and progression to chronic pancreatitis often involve genetic mutations. Herein, we describe a case of recurrent pancreatitis with the IVS3+2T>C mutation in the serine protease inhibitor Kazal type 1 (SPINK1) gene that progressed to chronic pancreatitis in only 3 years. A 35-year-old man was referred to our hospital, where he was diagnosed with mild pancreatitis and was treated conservatively. However, the patient experienced recurrent episodes of pancreatitis, which progressed to become chronic pancreatitis with a pancreatic calcification 1 year later. After 3 years, the patient developed pancreatic duct stenosis and required a pancreatic duct stent placement. Regarding the cause of chronic pancreatitis, alcohol abuse was ruled out based on history taking. Considering the course of treatment, autoimmune pancreatitis and obstructive pancreatitis, such as pancreatic divisum, were also ruled out. Finally, a germline genetic test was performed to determine the etiology of pancreatitis, which revealed the IVS3+2T>C mutation in SPINK1. This case shows the importance of genetic testing in patients with idiopathic pancreatitis to determine their etiology and is a rare incident that can report the progression of the disease from acute to chronic pancreatitis.2023年, Case reports in gastroenterology, 17(1) (1), 49 - 55, 英語, 国際誌
- 医学図書出版(株), 2022年11月, 胆と膵, 43(特別号) (特別号), 1385 - 1390, 日本語
- BACKGROUND AND AIM: Endoscopic ultrasonography (EUS) findings of the pancreatic parenchyma, such as hyperechoic foci/stranding and lobularity, may be associated with the severity of chronic pancreatitis (CP). However, the correlation between parenchymal EUS findings and histology remains unclear. We designed a large-scale retrospective study analyzing over 200 surgical specimens to elucidate the association between parenchymal EUS findings and histological features. METHODS: Clinical data of 221 patients with pancreatobiliary tumors who underwent preoperative EUS and pancreatic surgery between January 2010 and November 2020 were reviewed to investigate the association between parenchymal EUS findings and histological features at the pancreatic body. None of these patients met the definition of CP. RESULTS: Of the 221 patients, 87 (39.4%), 89 (40.2%), and 45 (20.4%) had normal EUS findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity, respectively. In the multivariate analyses, parenchymal EUS findings significantly correlated with histological CP findings of fibrosis, inflammation, and atrophy (hyperechoic foci/stranding without lobularity vs hyperechoic foci/stranding with lobularity, odds ratio [95% confidence interval]: 4.1 [2.2-7.9] vs 31.3 [9.3-105.6], Ptrend < 0.001; 3.9 [1.9-8.2] vs 21.8 [8.0-59.4], Ptrend < 0.001; and 4.0 [2.0-7.8] vs 22.9 [7.0-74.5], Ptrend < 0.001, respectively). Further, a trend toward higher histological grade was observed in the following order: normal findings, hyperechoic foci/stranding without lobularity, and hyperechoic foci/stranding with lobularity. CONCLUSIONS: Endoscopic ultrasonography findings of the pancreatic parenchyma may be associated with the histological conditions in CP, such as pancreatic fibrosis, inflammation, and atrophy. Lobularity reflects more severe histological conditions than does hyperechoic foci/stranding.2022年10月, Journal of gastroenterology and hepatology, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: A step-up approach is recommended as a new treatment algorithm for pancreatic fluid collections (PFCs). However, determining which patients with PFCs require a step-up approach after endoscopic ultrasound-guided transmural drainage (EUS-TD) is unclear. If the need for a step-up approach could be predicted, it could be performed early for relevant patients. We aimed to identify PFC-related predictive factors for a step-up approach after EUS-TD. METHODS: This retrospective cohort study included consecutive patients who had undergone EUS-TD for PFCs from January 2008 to May 2020. Multivariable logistic regression analyses were performed to investigate PFC factors related to requiring a step-up approach. A step-up approach was performed for patients who did not respond clinically to EUS-TD. RESULTS: We enrolled 81 patients, of whom 25 (30.9%) required a step-up approach. In multivariate logistic regression analysis, the pre-EUS-TD number of PFC-occupied regions ≥ 3 (multivariate odds ratio [OR] 16.2, 95% confidence interval [CI] 2.68-97.6, P = 0.002), the post-EUS-TD PFC-remaining percentage ≥ 35% (multivariate OR 19.9, 95% CI 2.91-136.1, P = 0.002), and a positive sponge sign, which is a distinctive computed tomography finding in the early stage after EUS-TD (multivariate OR 6.26, 95% CI 1.33-29.3, P = 0.020), were independent predictive factors associated with requiring a step-up approach for PFCs. CONCLUSION: Pre-EUS-TD PFC-occupied regions, post-EUS-TD PFC-remaining percentage, and a positive sponge sign were predictors of the need for a step-up approach. Patients with PFC with these findings should be offered a step-up approach whereas conservative treatment is recommended for patients without these findings. CLINICAL REGISTRATION NUMBER: UMIN 000030898.2022年09月, Surgical endoscopy, 英語, 国際誌研究論文（学術雑誌）
- 2022年09月, SCIENTIFIC REPORTS, 12(1) (1), 英語研究論文（学術雑誌）
- 2022年09月, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 英語研究論文（学術雑誌）
- 医学図書出版(株), 2022年08月, 胆と膵, 43(8) (8), 751 - 757, 日本語
- 医学図書出版(株), 2022年08月, 胆と膵, 43(8) (8), 751 - 757, 日本語
- BACKGROUND: Secondary sclerosing cholangitis, characterized by biliary obstruction, can be caused by drugs such as immune checkpoint inhibitors (ICIs). While there a few reports of sclerosing cholangitis after immune checkpoint inhibitor administration, no case has been reported after discontinuation of such drugs. CASE SUMMARY: A 68-year-old man who underwent chemotherapy for lung adenocarcinoma with bone metastasis presented with abdominal pain and fever 4 mo after the final administration of pembrolizumab. Computed tomography revealed thickening of the gallbladder wall and dilatation of the common bile duct. Endoscopic retro-grade cholangiopancreatography revealed an irregularly narrowed intrahepatic bile duct. Biopsy of the bile duct demonstrated that CD8+ T cells were predominant over CD4+ T cells. Liver biopsy showed dominant infiltration of CD8+ T in the portal tract, but onion-skin lesions were not observed. The patient was diagnosed with immune-related sclerosing cholangitis induced by pembrolizumab. Administration of methylprednisolone and endoscopic nasobiliary drainage were performed, but the cholangiography and laboratory test findings did not improve. No further treatment was administered due to disease progression, and the patient was referred for palliative care. CONCLUSION: Immune-related sclerosing cholangitis may have a late onset, and such cases occurring after discontinuation of ICIs should be carefully managed.2022年07月, World journal of gastroenterology, 28(28) (28), 3732 - 3738, 英語, 国際誌
- 日本消化器内視鏡学会-近畿支部, 2022年06月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 108回, 85 - 85, 日本語胆管空腸吻合部狭窄に対して直視型EUSを用いて再建腸管からの胆管空腸瘻孔形成術に成功した1例
- 日本消化器内視鏡学会-近畿支部, 2022年06月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 108回, 64 - 64, 日本語「胆膵内視鏡診断の現況と展望」 胆道癌の術前診断における経口胆道鏡の役割
- 日本消化器内視鏡学会-近畿支部, 2022年06月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 108回, 85 - 85, 日本語胆管空腸吻合部狭窄に対して直視型EUSを用いて再建腸管からの胆管空腸瘻孔形成術に成功した1例
- BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN) is defined as PDAC occurring apart from IPMN. This study comprehensively investigated the molecular biologic characteristics of PDAC concomitant with IPMN in major genetic alterations, tumor microenvironment, and prognosis by contrast with those of conventional PDAC. METHODS: The study retrospectively reviewed the data of 158 surgically resected PDAC patients. The driver gene alteration status (KRAS, TP53, CDKN2A, SMAD4, and GNAS) together with the immune and fibrotic status in tumor was evaluated. The prognosis of PDAC concomitant with IPMN and that of conventional PDAC also were compared. RESULTS: No statistically significant difference was found between PDAC concomitant with IPMN and conventional PDAC in the alteration frequency analysis of the major driver genes and the immune and fibrotic status in the tumor microenvironment. Overall survival and disease-free survival between patients who had PDAC concomitant with IPMN and those who had conventional PDAC did not show statistically significant differences in propensity-matched subjects. Furthermore, the co-existence of IPMN was not a poor prognostic factor in the multivariable-adjusted Cox proportional hazards model (hazard ratio, 0.95; 95 % confidence interval, 0.51-1.78). CONCLUSIONS: In this study, PDAC concomitant with IPMN had tumor characteristics similar to those of conventional PDAC in terms of the major driver gene alterations, tumor microenvironment, and prognosis.2022年05月, Annals of surgical oncology, 29(8) (8), 4924 - 4934, 英語, 国際誌研究論文（学術雑誌）
- 2022年05月, Annals of surgical oncology, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本消化器内視鏡学会, 2022年04月, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 810 - 810, 日本語悪性輸入脚狭窄に対する内視鏡的ステント留置術の検討
- (一社)日本消化器内視鏡学会, 2022年04月, Gastroenterological Endoscopy, 64(Suppl.1) (Suppl.1), 810 - 810, 日本語悪性輸入脚狭窄に対する内視鏡的ステント留置術の検討
- Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions of pancreatic cancer. An accurate serum biomarker, which allows earlier identification of asymptomatic individuals with high-risk for developing cancer, is of urgent need. Apolipoprotein A2-isoforms (apoA2-i) have previously been identified as biomarkers in pancreatic cancer. This study investigates a potential clinical application of the serum apoA2-i for risk stratification of IPMN and associated cancer. The concentrations of apoA2-i were retrospectively determined in 523 patient sera specimen, composed of 305 IPMNs with preinvasive lesions with different grades of dysplasia and invasive cancer, 140 pancreatic ductal adenocarcinoma, 78 with other cystic lesions and healthy controls cohorts, using an apoA2-i enzyme-linked immunosorbent assay kit. The diagnostic performance of serum apoA2-i was assessed and compared to routine clinical marker CA 19-9. ApoA2-i levels were significantly reduced in all IPMN samples regardless of stage compared to healthy controls. Receiver operating characteristic curve analysis of IPMNs with high-grade dysplasia and IPMN with associated carcinoma revealed the area under curve (AUC) of 0.91 and >0.94, respectively. The respective sensitivities were 70% and 83% with a specificity of 95%, and significantly higher than the gold standard biomarker CA 19-9. AUC values of apoA2-i for detecting IPMN-associated carcinoma of colloid and ductal subtypes were 0.990 and 0.885, respectively. ApoA2-i has the potential to early detect the risk of malignancy of patients with IPMN. The serological apoA2-i test in combination with imaging modalities could help improve the diagnosis of IPMN malignancy. Further validation in larger and independent international cohort studies is needed.2022年03月, International journal of cancer, 150(5) (5), 881 - 894, 英語, 国際誌研究論文（学術雑誌）
- 日本消化器病学会-近畿支部, 2022年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 116回, 60 - 60, 日本語膵癌診療の進歩と今後の展望 膵癌の腫瘍内線維化の予後における意義
- 日本消化器内視鏡学会-近畿支部, 2021年12月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 54 - 54, 日本語難治性胆膵疾患に対する内視鏡診療の取り組み 当院における膵癌に対する術前診断法の現状と課題
- 日本消化器内視鏡学会-近畿支部, 2021年12月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 89 - 89, 日本語合流部結石による胆嚢結腸瘻の一例
- 日本消化器内視鏡学会-近畿支部, 2021年12月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 107回, 93 - 93, 日本語膵臓に多発結節を認めEUS-FNAで診断し得たAIDS関連バーキットリンパ腫の一例
- The Korean Society of Gastrointestinal Endoscopy, 2021年11月, Clinical Endoscopy, 54(6) (6), 810 - 817研究論文（学術雑誌）
- (一財)日本消化器病学会, 2021年10月, 日本消化器病学会雑誌, 118(臨増大会) (臨増大会), A630 - A630, 日本語
- (株)東京医学社, 2021年09月, 消化器内視鏡, 33(9) (9), 1467 - 1475, 日本語
- 日本消化器病学会-近畿支部, 2021年09月, 日本消化器病学会近畿支部例会プログラム・抄録集, 115回, 91 - 91, 日本語自己免疫性膵炎を背景とした膵頭部に肺癌転移を来した一例
- (一社)日本癌学会, 2021年09月, 日本癌学会総会記事, 80回, [J14 - 5], 英語膵外分泌機能を評価し膵がんリスク集団を層別化する血液バイオマーカー開発
- (一社)日本膵臓学会, 2021年08月, 膵臓, 36(3) (3), A209 - A209, 日本語IgG4関連疾患up-to-date:病態、診断、治療の最新知見 当院における自己免疫性膵炎の長期予後と悪性腫瘍の発症および再燃リスク因子の検討
- (一社)日本膵臓学会, 2021年08月, 膵臓, 36(3) (3), A236 - A236, 日本語膵炎・膵癌のbench to bed:病態解明から新規治療法開発に向けて 急性膵炎におけるPLCεを介した炎症制御機構の解明
- (一社)日本胆道学会, 2021年08月, 胆道, 35(3) (3), 505 - 505, 日本語
- Afferent loop obstruction (ALO) is defined as duodenal or jejunal mechanical obstruction at the proximal anastomosis site of a gastrojejunostomy. With advances in chemotherapy, the incidence of malignant ALO is increasing. Malignant ALO can be complicated by ischemia, gangrenous bowel, pancreatitis, and ascending cholangitis. Moreover, the general condition of patients with recurrent cancer is often poor. Therefore, accurate and rapid diagnosis and minimally invasive treatments are required. However, no review articles on the diagnosis and treatment of malignant ALO have been published. Through literature searching, we reviewed related articles published between 1959 and 2020 in the PubMed database. Herein, we present recent advances in the diagnosis and treatment of malignant ALO and describe future perspectives. Endoscopic transluminal self-expandable metal stent (SEMS) placement is considered the standard treatment for malignant ALO, as this procedure is well established and less invasive. However, with the development of interventional endoscopic ultrasound (EUS) in recent years, the usefulness of EUS-guided gastrojejunostomy has been reported. Moreover, through indirect comparison, this approach has been reported to be superior to transluminal SEMS placement. It is expected that a safer and less invasive treatment method will be established through the continued advancement and innovation of interventional endoscopy techniques.2021年07月, World journal of gastrointestinal oncology, 13(7) (7), 684 - 692, 英語, 国際誌研究論文（学術雑誌）
- 日本消化器内視鏡学会-近畿支部, 2021年07月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 106回, 88 - 88, 日本語肝外門脈閉塞で形成されたCavernous transformationを合併した遠位胆管癌の一例
- (株)アークメディア, 2021年06月, 肝胆膵, 82(6) (6), 787 - 790, 日本語【分枝型IPMNの長期予後と進展様式】IPMNの長期予後 High risk stigmata非切除例の予後
- (株)アークメディア, 2021年06月, 肝胆膵, 82(6) (6), 797 - 802, 日本語【分枝型IPMNの長期予後と進展様式】IPMN由来癌と併存癌 IPMN併存癌の特徴 予後、遺伝子異常など通常型膵癌と比較して
- A 78-year-old man who underwent right nephrectomy for renal cell carcinoma (RCC) 18 years ago visited our hospital complaining of abdominal pain. Imaging revealed that the pancreatic head tumor obstructed the Santorini duct. We suspected a pancreatic intraductal tumor, such as an intraductal tubulopapillary neoplasm or intraductal papillary mucinous neoplasm. Thus, the patient underwent subtotal stomach-preserving pancreaticoduodenectomy. Pathological findings confirmed the diagnosis of metastatic RCC. Herein, we report a case of pancreatic metastasis of an RCC that presented with a tumor in the pancreatic duct.2021年06月, Clinical journal of gastroenterology, 14(3) (3), 905 - 909, 英語, 国内誌研究論文（学術雑誌）
- Highlight Atalla and colleagues present a novel dumbbell-shaped fully covered self-expandable metal stent which, with its anti-migration property and relatively lower cost, is a feasible and cost-effective option as an alternative to lumen-apposing metal stents for endoscopic ultrasound-guided transduodenal gallbladder drainage for acute cholecystitis in patients who are ineligible for surgery.2021年05月, Journal of hepato-biliary-pancreatic sciences, 28(5) (5), e19-e20, 英語, 国内誌研究論文（学術雑誌）
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 892 - 892, 日本語胆道出血に対する内視鏡治療の現状と課題 特に肝細胞癌からの胆道出血に関して
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 907 - 907, 日本語EUS-hepaticogastrostomyにおけるトラブルを未然に回避するためのダブルガイドワイヤー法
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 980 - 980, 日本語内視鏡的乳頭切除術を行った早期十二指腸乳頭部腫瘍の予後に関する検討
- 医学図書出版(株), 2021年04月, 胆と膵, 42(4) (4), 285 - 292, 日本語
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 892 - 892, 日本語胆道出血に対する内視鏡治療の現状と課題 特に肝細胞癌からの胆道出血に関して
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 907 - 907, 日本語EUS-hepaticogastrostomyにおけるトラブルを未然に回避するためのダブルガイドワイヤー法
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 976 - 976, 日本語乳酸リンゲル液の投与によるERCP後膵炎発症予防効果の検討
- (一社)日本消化器内視鏡学会, 2021年04月, Gastroenterological Endoscopy, 63(Suppl.1) (Suppl.1), 980 - 980, 日本語内視鏡的乳頭切除術を行った早期十二指腸乳頭部腫瘍の予後に関する検討
- (株)東京医学社, 2021年03月, 消化器内視鏡, 33(3) (3), 635 - 641, 日本語
- (一財)日本消化器病学会, 2021年03月, 日本消化器病学会雑誌, 118(臨増総会) (臨増総会), A323 - A323, 日本語治療困難胆管結石に対する電気衝撃波結石破砕術(EHL)の当院における現状と治療成績の検討
- 日本消化器病学会-近畿支部, 2021年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 114回, 59 - 59, 日本語膵管内腫瘍様の形態を呈した腎癌膵臓転移症例の一例
- 日本消化器病学会-近畿支部, 2021年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 114回, 59 - 59, 日本語膵管内腫瘍様の形態を呈した腎癌膵臓転移症例の一例
- Drug-induced pancreatitis is often mild to moderate in severity, but severe and even fatal cases can occur. Here, we report a 74-year-old woman undergoing chemotherapy for recurrent renal cell carcinoma, who presented with abdominal pain after administration of pazopanib following nivolumab and was diagnosed with severe acute pancreatitis. Administration of methylprednisolone and conservative treatment were initiated, but clinical findings and laboratory tests rapidly worsened. When she died, an autopsy was performed. The autopsy findings suggested the possibility of pancreatitis as immune-related adverse events. To the best of our knowledge, no fatal cases of acute pancreatitis due to nivolumab or pazopanib have been reported. We considered that the effects of nivolumab were sustained in the pancreas, and pazopanib administration might have worsened the toxicity.2021年01月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 21(1) (1), 21 - 24, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with acute pancreatitis (AP) in some cases, however its causes have not been fully elucidated. We investigated the association of the incidence of AP with epithelial subtypes and pancreatic volume in IPMN. METHODS: This retrospective study included 182 consecutive surgically resected IPMN patients between January 2000 and December 2018. The relationship between the incidence of AP and epithelial subtypes of IPMN and pancreatic volume was investigated. Epithelial subtypes of IPMN were classified into gastric (G type: N = 116), intestinal (I type: N = 49), pancreatobiliary (PB type: N = 14), and oncocytic types (O type: N = 3). Pancreatic volume of the contrast-enhanced computed tomography scan was measured using Ziostation2 software. Histological pancreatic parenchymal atrophy was also evaluated. RESULTS: AP occurred more frequently in I-types (I-type vs. G-type, 22.4% [11/49] vs 3.4% [4/116], P = 0.003) and PB-types (PB type vs. G-type, 35.7% [5/14] vs. 3.4% [4/116], P = 0.007) in comparison with G-types, which constituted the majority of the resected IPMNs. AP occurred more frequently in I-type patients with high pancreatic volumes (I-type with high pancreatic volume vs. I-type with low pancreatic volume, 37.0% [10/27] vs. 4.7% [1/21], P = 0.02). However, histological atrophy did not show an additional influence on the association between the incidence of AP and epithelial subtypes. The elevation of serum pancreatic enzymes was not significantly related to epithelial subtypes. CONCLUSION: Epithelial subtypes and the degree of pancreatic volume may be closely associated with the incidence of AP in IPMN.2021年01月, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 21(1) (1), 138 - 143, 英語, 国際誌研究論文（学術雑誌）
- Japanese Society of Internal Medicine, 2021年, Internal Medicine, 60(4) (4), 653 - 654, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- (株)メディカルレビュー社, 2020年12月, 胆膵Oncology Forum, 1(1) (1), 15 - 19, 日本語
- 日本消化器内視鏡学会-近畿支部, 2020年12月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 105回, 62 - 62, 日本語縦隔内膵仮性嚢胞に対し内視鏡的ドレナージが奏功した1例
- BACKGROUND: Surgical resection of intraductal papillary mucinous neoplasm (IPMN) is strongly recommended for patients exhibiting high-risk stigmata (HRS). However, determining surgical indications for elderly patients with comorbidities is challenging, as clinical outcomes are not well characterized. This multicenter observational study elucidated the clinical outcomes of patients with IPMN exhibiting HRS who did not undergo surgery. METHODS: This study enrolled 101 IPMN patients exhibiting HRS with follow-up observations at 11 hospitals in Japan (2011-2016). The median observation period was 37 months (maximum: 86 months). Primary outcomes were estimated 5-year overall survival (OS) and disease-specific survival (DSS). Survival was also stratified based on HRS features. RESULTS: Of 101 patients, 32 (31.7%) had the main pancreatic duct (MPD) measuring ≥ 10 mm and 80 (79.2%) had mural nodules measuring ≥ 5 mm. The estimated 5-year OS and DSS were 74% and 91%, respectively. In the stratified analysis, the co-presence of MPD ≥ 10 mm and mural nodules ≥ 5 mm or mural nodule ≥ 10 mm were related to worse 5-year DSS (MPD ≥ 10 mm and mural nodules ≥ 5 mm vs other characteristics: 60% vs 95%, log-rank test: p = 0.049; mural nodules ≥ 10 mm vs < 10 mm: 77% vs 95%, log-rank test: p = 0.003). CONCLUSIONS: The estimated 5-year DSS of conservatively managed IPMN patients with mural nodules and main duct dilation was 91%. Only IPMN patients with plural HRS or large nodule formation might have an increased mortality risk. This is an important insight that can help facilitate appropriate clinical decision-making, especially in the elderly or high-surgical risk IPMN patients.2020年10月, Journal of gastroenterology, 56(3) (3), 285 - 292, 英語, 国内誌研究論文（学術雑誌）
- (一社)日本癌治療学会, 2020年10月, 日本癌治療学会学術集会抄録集, 58回, WS27 - 1, 英語膵がんの治療戦略 ApoA2-isoforms血液バイオマーカースクリーニングによる膵がんリスク層別化
- (一社)日本癌学会, 2020年10月, 日本癌学会総会記事, 79回, OE15 - 4, 英語メタボローム解析による食道がんに対する化学放射線療法の効果予測マーカーの同定
- 日本消化器病学会-近畿支部, 2020年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 113回, 84 - 84, 日本語胆嚢癌との鑑別が困難であったIgG4関連硬化性胆嚢炎の一例
- 日本消化器病学会-近畿支部, 2020年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 113回, 84 - 84, 日本語胆嚢癌との鑑別が困難であったIgG4関連硬化性胆嚢炎の一例
- Apolipoprotein A2-ATQ/AT (apoA2-ATQ/AT) has been identified as a minimally invasive biomarker for detecting pancreatic cancer (PC) and high-risk (HR) individuals for PC. To establish an efficient enrichment strategy for HR, we carried out a plasma apoA2-ATQ/AT level-based prospective screening study among the general population. The subjects for the screening study were recruited at six medical check-up facilities in Japan between October 2015 and January 2017. We evaluated the positive predictive value (PPV) of the plasma apoA2-ATQ/AT level of ≤35 μg/mL for detecting PC and HR. Furthermore, we prospectively confirmed its diagnostic accuracy with another post-diagnosis population in a cross-sectional study. We enrolled 5120 subjects in experimental screening, with 84 subjects (1.3%) showing positive results for apoA2-ATQ/AT. Pancreatic abnormalities were recognized in 26 of the 84 subjects from imaging examinations. Pancreatic abnormalities detected included 1 PC and 15 HR abnormalities, such as cystic lesions including intraductal papillary mucinous neoplasm. The PPV of apoA2-ATQ/AT for detecting PC and HR was 33.3%. Moreover, a combination study with another cross-sectional study revealed that the area under the curve for apoA2-ATQ/AT to distinguish PC from healthy controls was 0.903. ApoA2-ATQ/AT has the potential to enrich PC and HR by increasing the diagnostic probability before imaging examinations.MDPI AG, 2020年09月, Cancers, 12(9) (9), 2625 - 2625, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- A 60-year-old male visited a previous hospital with upper abdominal pain. He was diagnosed with localized mild acute pancreatitis. Three months later, abdominal contrast-enhanced computed tomography showed focal parenchymal atrophy of the pancreas with distal pancreatic duct dilation. No obvious solid mass could be found at the site of the pancreatic duct stenosis on imaging examinations. Endoscopic retrograde pancreatography showed focal mild stenosis with distal pancreatic duct dilation in the tail of the pancreas. Carcinoma in situ of the pancreas was strongly suspected, especially based on the presence of focal atrophy of the pancreas around the site of stenosis of the main pancreatic duct and the distal pancreatic duct dilation. Laparoscopic distal pancreatectomy was performed. Histologically, high-grade pancreatic intraepithelial neoplasia was found in the epithelium of the stenotic main pancreatic duct and its branches. This case suggests that localized acute pancreatitis and focal atrophy of the pancreas with distal dilation of the pancreatic duct could be important clinical manifestations of pancreatic carcinoma in situ.Springer Science and Business Media LLC, 2020年08月, Clinical Journal of Gastroenterology, 13(6) (6), 1338 - 1342, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Wiley, 2020年08月, JGH Open, 4(4) (4), 677 - 683, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- In this study, we assessed a series of our cases in which endoscopic self-expandable metal stents (SEMSs) were used to treat malignant afferent loop obstruction (ALO) that arose after pancreaticoduodenectomy (PD). We retrospectively examined the records of 7 patients who underwent endoscopic SEMS placement for malignant ALO following PD. Clinical success was achieved in all cases. The median procedure time was 30 min (range, 15-50 min). There were no cases of stent occlusion, and no procedure-related adverse events were encountered. All patients died of their primary disease, and the median overall survival period was 155 days (range, 96-374 days). A re-intervention involving endoscopic ultrasound-guided hepaticogastrostomy combined with antegrade stenting was performed for obstructive jaundice and acute cholangitis in 1 case. In conclusion, endoscopic SEMS placement may be an effective and safe treatment for malignant ALO that arises after PD.The Korean Society of Gastrointestinal Endoscopy, 2020年07月, Clinical Endoscopy, 53(4) (4), 491 - 496, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本膵臓学会, 2020年07月, 膵臓, 35(3) (3), A202 - A202, 日本語
- (一社)日本膵臓学会, 2020年07月, 膵臓, 35(3) (3), A448 - A448, 日本語
- (一社)日本膵臓学会, 2020年07月, 膵臓, 35(3) (3), A150 - A150, 日本語
- (一社)日本膵臓学会, 2020年07月, 膵臓, 35(3) (3), A195 - A195, 日本語
- (一社)日本膵臓学会, 2020年07月, 膵臓, 35(3) (3), A316 - A316, 日本語
- (一財)日本消化器病学会, 2020年07月, 日本消化器病学会雑誌, 117(臨増総会) (臨増総会), A342 - A342, 日本語
- (一財)日本消化器病学会, 2020年07月, 日本消化器病学会雑誌, 117(臨増総会) (臨増総会), A391 - A391, 日本語
- Aim: The aim of this study was to identify whether metabolite biomarker candidates for pancreatic cancer (PC) could aid detection of intraductal papillary mucinous neoplasms (IPMN), recognized as high-risk factors for PC. Materials & methods: The 12 metabolite biomarker candidates, which were found to be useful to detect PC in our previous study, were evaluated for plasma samples from patients with PC (n = 44) or IPMN (n = 24) or healthy volunteers (n = 46). Results: Regarding the performance of individual biomarkers of PC and PC high-risk IPMN, lysine exhibited the best performance (sensitivity: 67.8%; specificity: 86.9%). The multiple logistic regression analysis-based detection model displayed high sensitivity and specificity values of 92.5 and 90.6%, respectively. Conclusion: Metabolite biomarker candidates for PC are useful for detecting high-risk IPMN, which can progress to PC.Future Medicine Ltd, 2020年07月, Biomarkers in Medicine, 14(11) (11), 1009 - 1020, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The purpose of the present study was to assess the differences between the human serum and plasma proteomes, and the stability of human plasma proteins under different storage conditions following blood collection, by means of SWATH-MS analysis. When we compared plasma and serum prepared immediately after blood sampling, 95.5% of 176 quantified proteins differed by less than 1.5-fold. When we compared plasma samples prepared by centrifugation after storage of blood at room temperature for 0, 15 or 30 min, or under refrigeration at 0-5 °C for 1, 4 or 8 h, no protein showed a significant change (q < 0.05) that amounted to 1.5-fold or more, except hemoglobins. Those proteins were greatly increased in a single sample at 8 h, probably due to hemolysis. Comparison of data from the same samples indicates that the blood proteome is more stable than the blood metabolome. The present results suggest that most components of the proteome are essentially the same in plasma and serum, and are stable under the storage conditions examined in the present study. However, it may be important to pay attention to the extent of coagulation, and levels of platelet and hemolysis-related proteins. SIGNIFICANCE: Pre-analytical processing and storage conditions after blood collection are expected to influence the blood proteome. Therefore, we investigated differences in the proteome between human serum and plasma, as well as the stability of human plasma proteins under different storage conditions: at room temperature for 0-30 min, or at 0-5 °C for 1-8 h, which may reflect the clinical situation of blood collection. Proteomics analysis with SWATH-MS identified 342 proteins, and 176 proteins quantified with two or more unique peptides were compared. The levels of most components of the proteome were similar in plasma and serum, and were stable under the storage conditions examined. However, it is necessary to consider the possibility of coagulation, as this affects the levels of platelet and hemolysis-related proteins. Interestingly, the blood proteome appears to be more stable than the blood metabolome, based on previously reported metabolomics data with same samples. These data will be helpful in designing protocols for blood sampling and for blood biomarker discovery and validation.Elsevier BV, 2020年07月, Journal of Proteomics, 223, 103824 - 103824, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Georg Thieme Verlag KG, 2020年06月, Endoscopy, 53(2) (2), E52-E53, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 日本消化器内視鏡学会-近畿支部, 2020年06月, 日本消化器内視鏡学会近畿支部例会プログラム・抄録集, 104回, 74 - 74, 日本語急性膵炎を契機に診断した膵上皮内癌の一例
- A 60-year-old female was admitted to hospital with a continuous fever, a decreased appetite, and abdominal pain. Laboratory tests showed an elevated peripheral leukocyte count (13,800/μl) and increased C-reactive protein (19.1 mg/dl) and carbohydrate antigen 19-9 (4057 U/ml) levels. Abdominal contrast-enhanced computed tomography showed multiple bulky hypovascular nodules in the liver, swelling of the paraaortic lymph nodes, and a hypovascular mass (diameter 3.0 cm) in the pancreatic body. The serum concentrations of granulocyte colony-stimulating factor (G-CSF) and interleukin-6 were 172 pg/μl and 541 pg/µl, respectively. Liver biopsy specimens revealed an adenosquamous carcinoma, which was positively immunostained for G-CSF. We diagnosed the patient with G-CSF-producing pancreatic cancer with multiple metastases. Four courses of gemcitabine with dexamethasone and one course of nab-paclitaxel and gemcitabine were administered. Although the pancreatic tumor and paraaortic lymph node metastases decreased in size, the liver metastases continued to grow. The patient died 4 months after the diagnosis of pancreatic cancer. An autopsy resulted in the tumor being diagnosed as poorly differentiated adenosquamous pancreatic carcinoma, which was histopathologically G-CSF-positive. Although G-CSF-producing pancreatic adenosquamous carcinomas are extremely rare, they have been encountered more frequently in recent years. In such cases, chemotherapy combined with dexamethasone might be effective at temporarily improving the patient's condition.Springer Science and Business Media LLC, 2020年06月, Clinical Journal of Gastroenterology, 13(3) (3), 448 - 454, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- In Japan, Kombu (Laminaria japonica), which is a type of seaweed, is considered to be a foodstuff with health-promoting benefits, and Japanese people actively incorporate Kombu into their diets. Previously, we reported that the frequent intake of Kombu reduced the serum triglyceride levels of subjects with abnormally high serum triglyceride levels. In the current human study, we performed metabolomic analysis of serum lipids, and then the molecular species profiles of phosphatidylcholines (PC), phosphatidylethanolamines (PE), lysophosphatidylcholines (LPC), lysophosphatidylethanolamines (LPE), and free fatty acids (FFA) were evaluated. As a result, it was found that there were no marked differences between the lipid profiles obtained before and after the intake of Kombu for 4 wk in all subjects. In the subjects with abnormal serum triglyceride levels, the intake of Kombu improved the subjects' molecular species profiles in terms of their serum levels of the diacyl and acyl forms of PC, PE, LPC, and LPE, and FFA. Furthermore, the intake of Kombu also tended to increase the serum levels of both the plasmanyl and plasmenyl forms of PC and PE in these subjects. The lipid alterations observed in our study might be related to the functionality of Kombu. Furthermore, it is important to evaluate the quality of lipids as well as the quantity of lipids in various types of research, including food functionality studies.Center for Academic Publications Japan, 2020年04月, Journal of Nutritional Science and Vitaminology, 66(2) (2), 185 - 190, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Wiley, 2020年04月, Journal of Gastroenterology and Hepatology, 35(10) (10), 1667 - 1667[査読有り]研究論文（学術雑誌）
- A 66-year-old Japanese man was referred to our hospital with multiple giant liver cysts. The cysts had already been detected as multiple 3-cm cysts with small nodules at another hospital 12 years prior to this presentation. The cysts were diagnosed as an intraductal papillary neoplasms of the bile duct (IPNB) occupying the right lobe of the liver. Extended right lobectomy was performed. Based on the pathological findings, the tumor was diagnosed to be an oncocytic-type IPNB with minimal invasion. This experience suggests that the progression of IPNBs occur relatively slowly. The present case might provide important information for understanding the natural history of IPNBs.Japanese Society of Internal Medicine, 2020年, Internal Medicine, 59(22) (22), 2879 - 2883, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2019年11月, FOOD SCIENCE AND TECHNOLOGY RESEARCH, 25(6) (6), 827 - 834, 英語研究論文（学術雑誌）
- Georg Thieme Verlag KG, 2019年11月, Endoscopy, 51(11) (11), E327 - E328[査読有り]研究論文（学術雑誌）
- Georg Thieme Verlag KG, 2019年10月, Endoscopy, 51(10) (10), E303 - E304[査読有り]研究論文（学術雑誌）
- (一社)日本癌学会, 2019年09月, 日本癌学会総会記事, 78回, SS - 4, 英語がん研究における女性研究者(第6回) 血液中分岐鎖アミノ酸濃度と膵臓がん罹患の関連について コホート内症例対照研究(Women scientists in cancer research Association between plasma levels of branched-chain amino acid and risk of pancreatic cancer in a large cohort)
- Wiley, 2019年09月, Journal of Gastroenterology and Hepatology, 34(9) (9), 1648 - 1655[査読有り]研究論文（学術雑誌）
- Wiley, 2019年08月, Journal of Gastroenterology and Hepatology, 34(8) (8), 1274 - 1274[査読有り]研究論文（学術雑誌）
- Informa UK Limited, 2019年07月, Expert review of molecular diagnostics, 19(8) (8), 651 - 654[査読有り]研究論文（学術雑誌）
- Eosinophilic cholangitis (EC) is an uncommon, benign, self-limiting disease, which typically causes bile duct stricture with eosinophil infiltration. We report the case of a 70-year-old woman who presented with abdominal pain diagnosed with EC after treatment for eosinophilic esophagitis. All previous reported cases of EC had bile duct stricture seen on magnetic resonance cholangiopancreatography or cholangiogram during endoscopic retrograde cholangiopancreatography, but only wall thickness of the common bile duct was noted in our case. Although rare, EC should be considered when wall thickening of the bile duct is observed, even without stricture.Ovid Technologies (Wolters Kluwer Health), 2019年06月, ACG Case Reports Journal, 6(6) (6), e00099 - e00099, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Elsevier {BV}, 2019年04月, Pancreatology, 19(3) (3), 424 - 428[査読有り]研究論文（学術雑誌）
- BACKGROUND: Endoscopic papillectomy (EP) for benign ampullary neoplasms could be a less-invasive alternative to pancreatoduodenectomy (PD). There are some problems and limitations with EP. The post-EP resection margins of ampullary tumors are often positive or uncertain because of the burning effect of EP. The clinical outcomes of resected margin positive or uncertain cases after EP remain unknown. AIM: To investigate the clinical outcomes of resected margin positive or uncertain cases after EP. METHODS: Between January 2007 and October 2018, all patients with ampullary tumors who underwent EP at Kobe University Hospital were included in this study. The indications for EP were as follows: adenoma, as determined by preoperative endoscopic biopsy, without bile/pancreatic duct extension, according to endoscopic ultrasound or intraductal ultrasound. The clinical outcomes of resected margin positive or uncertain cases after EP were retrospectively investigated. RESULTS: Of the 45 patients, 29 were male, and 16 were female. The mean age of the patients was 65 years old. Forty-one patients (89.5%) underwent en bloc resection, and 4 patients (10.5%) underwent piecemeal resection. After EP, 33 tumors were histopathologically diagnosed as adenoma, and 12 were diagnosed as adenocarcinoma. The resected margins were positive or uncertain in 24 patients (53.3%). Of these cases, 15 and 9 were diagnosed as adenoma and adenocarcinoma, respectively. Follow-up observation was selected for all adenomas and 5 adenocarcinomas. In the remaining 4 adenocarcinoma cases, additional PD was performed. Additional PD was performed in 4 cases, and residual carcinoma was found after the additional PD in 1 of these cases. In the follow-up period, local tumor recurrence was detected in 3 cases. Two of these cases involved primary EP-diagnosed adenoma. The recurrent tumors were also adenomas detected by biopsy. The remaining case involved primary EP-diagnosed adenocarcinoma. The recurrent tumor was also an adenocarcinoma. All of the recurrent tumors were successfully treated with argon plasma coagulation (APC). There was no local or lymph node recurrence after the APC. The post-APC follow-up periods lasted for 57.1 to 133.8 mo. No ampullary tumor-related deaths occurred in all patients. CONCLUSION: Resected margin positive or uncertain cases after EP could be managed by endoscopic treatment including APC, even in cases of adenocarcinoma. EP could become an effective less-invasive first-line treatment for early stage ampullary tumors.Baishideng Publishing Group Inc., 2019年03月, World Journal of Gastroenterology, 25(11) (11), 1387 - 1397, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: IgG4-related disease involves various organs including the pituitary and pancreas. The prevalence of IgG4-related hypophysitis is relatively rare compared with IgG4-related pancreatitis (autoimmune pancreatitis). Although several cases demonstrating both autoimmune pancreatitis and hypophysitis have been reported, the prevalence of IgG4-related hypophysitis in patients with autoimmune pancreatitis remains unknown. This study aimed at screening for IgG4-related hypophysitis to accurately determine its prevalence in patients with autoimmune pancreatitis. METHODS: In this cohort study, we screened IgG4-related hypophysitis via pituitary magnetic resonance imaging (MRI) and endocrinological examination in 27 patients who were undergoing follow-up for autoimmune pancreatitis at Kobe University Hospital between 2014 and 2018. RESULTS: Among 27 patients with autoimmune pancreatitis, 5 patients exhibited morphological abnormalities in the pituitary (18.5%). Among them, one patient (3.7%) met the criteria for hypophysitis with an enlarged pituitary and stalk concomitant with hypopituitarism. After glucocorticoid treatment, the enlarged pituitary shrank and became empty sella during the clinical course. Four patients (14.8%) revealed empty sella without obvious pituitary dysfunction. Four of 5 patients with morphological pituitary abnormalities showed multiple organ involvement in addition to pancreatic and pituitary involvement. Accordingly, multiple organ involvement was more prevalent in patients with morphological pituitary abnormalities (80%) compared to those without (48%). CONCLUSIONS: Although a large-scale study is necessary to validate these results, these data suggest that the prevalence of hypophysitis in patients with autoimmune pancreatitis may be underestimated. Based on our findings, we recommend screening for hypophysitis, especially in patients with multiple organ involvement.Springer Science and Business Media LLC, 2019年02月, Pituitary, 22(1) (1), 54 - 61, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年, The Kobe journal of medical sciences[査読有り]研究論文（学術雑誌）
- Blood tests, which are used to evaluate health status, are relatively non-invasive and provide a great deal of health-related information. Blood is usually collected using a standard venous blood sampling protocol, but it is possible to collect blood from a subject's fingertip, and previous studies have investigated whether fingertip-derived blood can be used for various blood tests. In this study, the proteomes and metabolomes of venous and fingertip plasma were analyzed using non-targeted proteomics and metabolomics, respectively. In proteomics, the levels of 523 proteins were compared between venous and fingertip plasma. The correlation coefficient (r) for the relationship between protein levels of venous and fingertip plasma was 0.9999. Some proteins had high fingertip to venous plasma level ratios (finger:venous ratios), whereas others had low finger:venous ratios, and the mean±standard deviation (SD) finger:venous ratio was 0.994 ± 0.304. In metabolomics, 40, 33, and 216 cationic metabolites, anionic metabolites, and lipids, respectively, were detected in venous plasma, and the equivalent figures for fingertip plasma were 40, 35, and 216, respectively. Regarding the correlations between metabolite levels in venous and fingertip plasma, the correlation coefficients (r) for cationic metabolites, anionic metabolites, and lipids were 0.9952, 0.9699, and 0.9980, respectively. The mean±SD finger:venous ratio was 1.19 ± 0.584 for cationic metabolites, 1.23 ± 0.548 for anionic metabolites, and 1.00 ± 0.245 for lipids. Our study suggests that it might be possible to use fingertip plasma to measure plasma protein and metabolite levels, and will contribute to development of a fingertip blood sampling procedure for measuring blood biomarker levels.Elsevier BV, 2019年01月, Talanta, 192, 182 - 188, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND/AIM: Neoadjuvant chemoradiotherapy has side-effects that adversely affect patients' quality of life. The aim of this study was to identify serum metabolite biomarkers that might be used to predict the side-effects of neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: Metabolomic analysis of serum samples from 26 patients with ESCC that were collected before neoadjuvant chemoradiotherapy was performed. The metabolites associated with hematological toxicity or nephrotoxicity were evaluated. RESULTS: Serum levels of glutaric acid, glucuronic acid, and cystine were significantly higher in hematological toxicity, and phosphatidylcholines and phosphatidylethanolamines exhibited a tendency to be higher in those with hematological toxicity. The serum level of pyruvic acid was significantly lower in nephrotoxicity, and lysophosphatidylcholines and lysophosphatidylethanolamines tended to be lower in those with nephrotoxicity. CONCLUSION: Our study found that serum levels of some metabolites differed significantly between patients with and without hematological or renal side-effects. These metabolites may be useful biomarkers for predicting hematological toxicity or nephrotoxicity after neoadjuvant chemoradiotherapy for ESCC.International Institute of Anticancer Research, 2019年01月, Anticancer Research, 39(1) (1), 519 - 526, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- The survival times of patients with advanced colorectal cancer (CRC) have increased due to the introduction of chemotherapy involving irinotecan and cetuximab. However, further studies are required on the effective pretreatment methods for identifying patients with CRC who would respond to particular treatments. The aim of the present study was to identify biomarkers for predicting the efficacy of chemotherapy for CRC. A total of 123 serum samples were collected from 31 patients with CRC just prior to each of the first four rounds of chemotherapy. Serum metabolome analysis was performed using a multiplatform metabolomics system, and univariate Cox regression hazards analysis of the time to disease progression was conducted. Octanoic acid and 1,5-anhydro-D-glucitol were identified as biomarker candidates. In addition, the serum level of octanoic acid was indicated to be significantly associated with the time to disease progression (hazard ratio, 3.3; 95% confidence interval, 1.099-11.840; P=0.033). The serum levels of fatty acids, in particular polyunsaturated fatty acids, tended to be downregulated in the partial response group. The findings of the present study suggest that the serum level of octanoic acid may serve as a useful predictor for the prognosis of CRC.Spandidos Publications, 2018年11月, Oncology Letters, 17(1) (1), 831 - 842, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND & AIMS: A marker is needed to identify individuals at risk for pancreatic cancer. Increases in branched-chain amino acids (BCAAs) have been associated with pancreatic cancer. We performed a prospective case-control study to study the association between plasma BCAA levels and risk of pancreatic cancer in a large cohort. METHODS: We conducted a nested case-control study selected from 30,239 eligible participants 40-69 years old within the Japan Public Health Center-based prospective study. Over 16.4 years, 170 newly diagnosed pancreatic cancer cases were identified. Each case was matched to 2 controls by age, gender, geographic area, and fasting time at blood collection. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for pancreatic cancer were calculated using conditional logistic regression models with adjustment for potential confounding factors. RESULTS: Increased plasma BCAA levels at baseline were associated with an increased risk of pancreatic cancer. Compared with the lowest quartile of BCAA levels, the OR in the highest quartile was 2.43 (95% CI 1.21-4.90), and the OR per 1 SD increase in BCAA levels was 1.32 (95% CI 1.05-1.67). The association was especially strong for cases with blood samples collected at least 10 years before cancer diagnosis (OR per SD 1.60, 95% CI 1.10-2.32) compared with those detected less than 10 years before diagnosis (OR per SD 1.16, 95% CI 0.86-1.57). CONCLUSIONS: In an analysis of data from the Japan Public Health Center-based prospective study, we found an association between increased plasma BCAA level and increased risk of pancreatic cancer-particularly when the increase in BCAAs was observed at least 10 years before diagnosis. These findings add to the growing body of evidence for the association between BCAA levels and pancreatic cancer risk.Elsevier BV, 2018年11月, Gastroenterology, 155(5) (5), 1474 - 1482.e1, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本医用マススペクトル学会, 2018年08月, JSBMS Letters, 43(Suppl.) (Suppl.), 71 - 71, 日本語
- AIM: To identify the serum metabolomics signature that is correlated with the chemoradiosensitivity of esophageal squamous cell carcinoma (ESCC). MATERIALS & METHODS: Untargeted and targeted metabolomics analysis of serum samples from 26 ESCC patients, which were collected before the neoadjuvant chemoradiotherapy, was performed. RESULTS: On receiving the results of untargeted metabolomics analysis, we performed the targeted metabolomics analysis of the six metabolites (arabitol, betaine, glycine, L-serine, L-arginine and L-aspartate). The serum levels of the four metabolites (arabitol, glycine, L-serine and L-arginine) were significantly lower in the patients who achieved pathological complete response with neoadjuvant chemoradiotherapy compared with the patients who did not achieve pathological complete response (p = 0.0086, 0.0345, 0.0106 and 0.0373, respectively). CONCLUSION: The serum levels of metabolites might be useful for predicting the chemoradiosensitivity of ESCC patients.Future Medicine Ltd, 2018年08月, Biomarkers in Medicine, 12(8) (8), 827 - 840, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Georg Thieme Verlag KG, 2018年08月, Endoscopy, 50(08) (08), E229 - E230, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年06月, Pancreatology, 18(4) (4), 399 - 406, 英語[査読有り]研究論文（学術雑誌）
- Discovery of a high-risk group for pancreatic cancer is important for prevention of pancreatic cancer. The present study was conducted as a nested case-control study including 170 pancreatic cancer cases and 340 matched controls of our population-based cohort study involving 30 239 subjects who answered a baseline questionnaire and supplied blood samples. Twelve targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were calculated using conditional logistic regression models. Statistically significant P-value was defined as P < .05. Increasing 1,5-anhydro-d-glucitol (1,5-AG) levels were associated with a decreasing trend in pancreatic cancer risk (OR of quartile 4 [Q4], 0.50; 95% CI, 0.27-0.93; P = .02). Increasing methionine levels were also associated with an increasing trend of pancreatic cancer risk (OR of Q4, 1.79; 95% CI, 0.94-3.40: P = .03). Additional adjustment for potential confounders attenuated the observed associations of 1,5-AG and methionine (P for trend = .06 and .07, respectively). Comparing subjects diagnosed in the first 0-6 years, higher levels of 1,5-AG, asparagine, tyrosine and uric acid showed a decreasing trend for pancreatic cancer risk (P for trend = .04, .04, .04 and .02, respectively), even after adjustment for potential confounders. We found that the 12 target metabolites were not associated with pancreatic cancer risk. However, metabolic changes in the subjects diagnosed in the first 0-6 years showed a similar tendency to our previous reports. These results might suggest that these metabolites are useful for early detection but not for prediction of pancreatic cancer.Wiley, 2018年05月, Cancer Science, 109(5) (5), 1672 - 1681, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Recently, the use of metabolomic analysis of human serum and plasma for biomarker discovery and disease diagnosis in clinical studies has been increasing. The feasibility of using a metabolite biomarker for disease diagnosis is strongly dependent on the metabolite's stability during pre-analytical blood processing procedures, such as serum or plasma sampling and sample storage prior to centrifugation. However, the influence of blood processing procedures on the stability of metabolites has not been fully characterized. In the present study, we compared the levels of metabolites in matched human serum and plasma samples using gas chromatography coupled with mass spectrometry and liquid chromatography coupled with mass spectrometry. In addition, we evaluated the changes in plasma metabolite levels induced by storage at room temperature or at a cold temperature prior to centrifugation. As a result, it was found that 76 metabolites exhibited significant differences between their serum and plasma levels. Furthermore, the pre-centrifugation storage conditions significantly affected the plasma levels of 45 metabolites. These results highlight the importance of blood processing procedures during metabolome analysis, which should be considered during biomarker discovery and the subsequent use of biomarkers for disease diagnosis.Elsevier BV, 2018年05月, Journal of Bioscience and Bioengineering, 125(5) (5), 613 - 618, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年03月, Biochemical and Biophysical Research Communications, 497(3) (3), 903 - 907, 英語[査読有り]研究論文（学術雑誌）
- 2018年01月, Pancreatology, 18(1) (1), 54 - 60, 英語[査読有り]研究論文（学術雑誌）
- 日本胆道学会, 2017年12月, 胆道, 31(5) (5), 793 - 801, 日本語
- 日本膵臓学会, 2017年10月, 膵臓, 32(5) (5), 829 - 835, 日本語
- (一社)日本医用マススペクトル学会, 2017年08月, JSBMS Letters, 42(Suppl.) (Suppl.), 95 - 95, 日本語
- BACKGROUND: This study was designed to identify novel links between lipid species and disease progression in non-alcoholic fatty liver disease (NAFLD). METHODS: We analyzed lipid species in the liver and plasma of db/db mice fed a choline-deficient l-amino acid-defined, high-fat diet (CDAHFD) using liquid chromatography/mass spectrometry (LC/MS). An in vitro experiment was performed using HepG2 cells stimulated with recombinant human TNFα or IL1β. The expression of steatosis-, inflammation-, and fibrosis-related genes were analyzed. Plasma samples from NAFLD patients were also analyzed by LC/MS. RESULTS: The CDAHFD-fed db/db mice with hepatic steatosis, inflammation, mild fibrosis, obesity, and hypercholesterolemia displayed significantly higher hepatic and plasma levels of free adrenic acid (p < 0.05). The accumulated adrenic acid in the CDAHFD-fed db/db mice was associated with increased expression of ELOVL2 and 5, and the suppression of the acyl-CoA oxidase 1 gene during peroxisomal β-oxidation. The pretreatment of HepG2 cells with adrenic acid enhanced their cytokine-induced cytokines and chemokines mRNA expression. In NAFLD patients, the group with the highest ALT levels exhibited higher plasma adrenic acid concentrations than the other ALT groups (p-value for trend <0.001). CONCLUSION: Data obtained demonstrated that adrenic acid accumulation contributes to disease progression in NAFLD.Elsevier BV, 2017年06月, Archives of Biochemistry and Biophysics, 623-624, 64 - 75, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- RATIONALE: The analytical stability and throughput of biomarker assays based on dried serum spots (DSS) are strongly dependent on the extraction process and determination method. In the present study, an on-line system based on supercritical fluid extraction-supercritical fluid chromatography coupled with tandem mass spectrometry (SFE-SFC/MS/MS) was established for analyzing the levels of disease biomarkers in DSS. METHODS: The chromatographic conditions were investigated using the ODS-EP, diol, and SIL-100A columns. Then, we optimized the SFE-SFC/MS/MS method using the diol column, focusing on candidate biomarkers of oral, colorectal, and pancreatic cancer that were identified using liquid chromatography (LC)/MS/MS. RESULTS: By using this system, four hydrophilic metabolites and 17 hydrophobic metabolites were simultaneously detected within 15 min. In an experiment involving clinical samples, PC 16:0-18:2/16:1-18:1 exhibited 93.8% sensitivity and 64.3% specificity, whereas PC 17:1-18:1/17:0-18:2 showed 81.3% sensitivity and 92.9% specificity for detecting oral cancer. In addition, assessments of the creatine levels demonstrated 92.3% sensitivity and 78.6% specificity for detecting colorectal cancer. CONCLUSIONS: The results of this study indicate that our method has great potential for clinical diagnosis and would be suitable for large-scale screening. Copyright © 2017 John Wiley & Sons, Ltd.Wiley, 2017年05月, Rapid Communications in Mass Spectrometry, 31(10) (10), 886 - 894, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: To improve prognosis of pancreatic cancer (PC) patients, the discovery of more reliable biomarkers for the early detection is desired. METHODS: Blood samples were collected by 2 independent groups. The 1st set was included 55 early PC and 58 healthy volunteers (HV), and the 2nd set was included 16 PC and 16HV. The 16 targeted metabolites were quantitatively analyzed by gas chromatography/tandem mass spectrometry together with their corresponding stable isotopes. In the 1st set, the levels of these metabolites were evaluated, and diagnostic models were constructed via multivariate logistic regression analysis, leading to validation using the 2nd set. RESULTS: In the 1st set, model X consisting of 4 candidates based on our previous report possessed higher sensitivity (74.1%) than carbohydrate antigen 19-9 (CA19-9). Model Y, consisting of 2 metabolites newly selected from 16 metabolites via stepwise method possessed higher sensitivity (70.4%) than CA19-9. Furthermore, combining model Y with CA19-9 increased its sensitivity (90.7%) and specificity (89.5%). In the 2nd set, combining model Y with CA19-9 displayed high sensitivity (81.3%) and specificity (93.8%). In particular, it displayed very high sensitivity (100%) for resectable PC. CONCLUSIONS: Quantitative analysis confirmed that metabolomics-based diagnostic methods are useful for detecting PC early.Elsevier BV, 2017年05月, Clinica Chimica Acta, 468, 98 - 104, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Ovid Technologies (Wolters Kluwer Health), 2017年04月, Pancreas, 46(4) (4), 582 - 588, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- In developed countries, the number of patients with colorectal cancer has been increasing, and colorectal cancer is one of the most common causes of cancer death. To improve the quality of life of colorectal cancer patients, it is necessary to establish novel screening methods that would allow early detection of colorectal cancer. We performed metabolome analysis of a plasma sample set from 282 stage 0/I/II colorectal cancer patients and 291 healthy volunteers using gas chromatography/triple-quadrupole mass spectrometry in an attempt to identify metabolite biomarkers of stage 0/I/II colorectal cancer. The colorectal cancer patients included patients with stage 0 (N=79), I (N=80), and II (N=123) in whom invasion and metastasis were absent. Our analytical system detected 64 metabolites in the plasma samples, and the levels of 29 metabolites differed significantly (Bonferroni-corrected p=0.000781) between the patients and healthy volunteers. Based on these results, a multiple logistic regression analysis of various metabolite biomarkers was carried out, and a stage 0/I/II colorectal cancer prediction model was established. The area under the curve, sensitivity, and specificity values of this model for detecting stage 0/I/II colorectal cancer were 0.996, 99.3%, and 93.8%, respectively. The model's sensitivity and specificity values for each disease stage were >90%, and surprisingly, its sensitivity for stage 0, specificity for stage 0, and sensitivity for stage II disease were all 100%. Our predictive model can aid early detection of colorectal cancer and has potential as a novel screening test for cases of colorectal cancer that do not involve lymph node or distant metastasis.Impact Journals, LLC, 2017年03月, Oncotarget, 8(10) (10), 17115 - 17126, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- S. Karger AG, 2017年, Oncology, 93(1) (1), 61 - 68, 英語[査読有り]研究論文（学術雑誌）
- 2017年, Kobe Journal of Medical Sciences, 63(1) (1)History of post-endoscopic retrograde cholangiopancreatography pancreatitis and acute pancreatitis as risk factors for post-ERCP pancreatitis[査読有り]研究論文（学術雑誌）
- 2017年01月, Pancreatology, 17(1) (1), 123 - 129, 英語[査読有り]研究論文（学術雑誌）
- 2016年09月, Pancreatology, 16(5) (5), 893 - 899, 英語[査読有り]研究論文（学術雑誌）
- AIM: To examine a novel screening method for pancreatic cancer involving gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry-based metabolomics analysis. MATERIALS & METHODS: Sera from pancreatic cancer patients (n = 59) and healthy volunteers (n = 59) were allocated to the training set or validation set. Serum metabolome analysis was carried out using our multiplatform metabolomics system. A diagnostic model was constructed using a two-phase screening method that was newly advocated. RESULTS: When the training set was used, the constructed diagnostic model exhibited high sensitivity (100%) and specificity (80%) for pancreatic cancer. When the validation set was used, the model displayed high sensitivity (84.1%) and specificity (84.1%). CONCLUSION: We successfully developed a diagnostic model for pancreatic cancer using a multiplatform serum metabolomics system.Future Medicine Ltd, 2016年06月, Biomarkers in Medicine, 10(6) (6), 577 - 586, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2016年, Metabolomics, 12(4) (4)[査読有り]研究論文（学術雑誌）
- 日本膵臓学会, 2015年05月, 膵臓, 30(3) (3), 443 - 443, 日本語
- Springer Science and Business Media LLC, 2015年04月, Clinical Journal of Gastroenterology, 8(2) (2), 103 - 107, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- PURPOSE: Cancer cachexia is a multifactorial syndrome characterized by progressive loss of weight and muscle atrophy. Using metabolomics, we investigated serum markers and their intra-day variation in advanced pancreatic cancer patients with cachexia. METHODS: Patients were enrolled in two groups: those with or without cachexia. Blood samples collected at 6:30 AM, 11:30 AM, 4:30 PM, and 9:30 PM were analyzed using metabolomics, and serum levels of IL-6, TNF-α, and leptin were measured and compared between the two groups. Intra-day variation was then evaluated. RESULTS: Twenty-one patients were enrolled in total. In the cachexia group (n = 9), median body weight loss rate over 6 months was greater, performance status was poorer, and anorexia was more severe than in the non-cachexia group (n = 12). Each metabolites level showed substantial intra-day variation, and some of them displayed significant differences between the two groups. Levels of paraxanthine remained markedly lower in the cohort with cachexia at all measurement points. Besides, median IL-6 and TNF-α levels appeared higher and leptin concentration appeared lower in the cachexia group, albeit without statistical significance. CONCLUSION: Some metabolites and some serological marker levels were affected by cancer cachexia. Although paraxanthine levels were consistently lower in patients with cachexia, we identified that many metabolites indicated large intra- and inter-day variation and that it might be necessary to pay attention to intra-day variation in metabolomics research.Public Library of Science (PLoS), 2014年11月, PLoS ONE, 9(11) (11), e113259 - e113259, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本消化器内視鏡学会, 2014年09月, Gastroenterological Endoscopy, 56(Suppl.2) (Suppl.2), 3052 - 3052, 日本語膵腫瘤性病変における造影ハーモニックEUSの有用性
- (一社)日本消化器内視鏡学会, 2014年09月, Gastroenterological Endoscopy, 56(Suppl.2) (Suppl.2), 3056 - 3056, 日本語膵頭十二指腸切除術後の悪性輸入脚狭窄に対する内視鏡的消化管金属ステント治療の有用性
- 日本胆道学会, 2014年08月, 胆道, 28(3) (3), 516 - 516, 日本語
- 日本膵臓学会, 2014年06月, 膵臓, 29(3) (3), 465 - 465, 日本語
- 日本膵臓学会, 2014年06月, 膵臓, 29(3) (3), 565 - 565, 日本語
- 日本膵臓学会, 2014年06月, 膵臓, 29(3) (3), 579 - 579, 日本語
- (一社)日本消化器内視鏡学会, 2014年04月, Gastroenterological Endoscopy, 56(Suppl.1) (Suppl.1), 1303 - 1303, 日本語当院での総胆管結石治療におけるEPLBD法の現状と問題点
- 2013年10月, Cancer Epidemiology Biomarkers & Prevention, 22(10) (10), 1922 - 1922, 英語[査読有り]研究論文（学術雑誌）
- American Association for Cancer Research (AACR), 2013年04月, Cancer Epidemiology Biomarkers & Prevention, 22(4) (4), 571 - 579, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一財)日本消化器病学会, 2013年02月, 日本消化器病学会雑誌, 110(臨増総会) (臨増総会), A211 - A211, 日本語APC遺伝子変異が大腸癌の代謝プロファイルに与える影響についての検討
- 2013年, Head and Neck Oncology, 5(4) (4), 40, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: To improve the quality of life of colorectal cancer patients, it is important to establish new screening methods for early diagnosis of colorectal cancer. METHODOLOGY/PRINCIPAL FINDINGS: We performed serum metabolome analysis using gas-chromatography/mass-spectrometry (GC/MS). First, the accuracy of our GC/MS-based serum metabolomic analytical method was evaluated by calculating the RSD% values of serum levels of various metabolites. Second, the intra-day (morning, daytime, and night) and inter-day (among 3 days) variances of serum metabolite levels were examined. Then, serum metabolite levels were compared between colorectal cancer patients (N = 60; N = 12 for each stage from 0 to 4) and age- and sex-matched healthy volunteers (N = 60) as a training set. The metabolites whose levels displayed significant changes were subjected to multiple logistic regression analysis using the stepwise variable selection method, and a colorectal cancer prediction model was established. The prediction model was composed of 2-hydroxybutyrate, aspartic acid, kynurenine, and cystamine, and its AUC, sensitivity, specificity, and accuracy were 0.9097, 85.0%, 85.0%, and 85.0%, respectively, according to the training set data. In contrast, the sensitivity, specificity, and accuracy of CEA were 35.0%, 96.7%, and 65.8%, respectively, and those of CA19-9 were 16.7%, 100%, and 58.3%, respectively. The validity of the prediction model was confirmed using colorectal cancer patients (N = 59) and healthy volunteers (N = 63) as a validation set. At the validation set, the sensitivity, specificity, and accuracy of the prediction model were 83.1%, 81.0%, and 82.0%, respectively, and these values were almost the same as those obtained with the training set. In addition, the model displayed high sensitivity for detecting stage 0-2 colorectal cancer (82.8%). CONCLUSIONS/SIGNIFICANCE: Our prediction model established via GC/MS-based serum metabolomic analysis is valuable for early detection of colorectal cancer and has the potential to become a novel screening test for colorectal cancer.Public Library of Science (PLoS), 2012年07月, PLoS ONE, 7(7) (7), e40459 - e40459, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Novel and effective drugs against acute pancreatitis are required. Therefore, we examined the changes in the metabolite levels in the serum and pancreatic tissue of mice with cerulein- and arginine-induced pancreatitis using gas-chromatography/mass-spectrometry (GC/MS) and investigated whether these alterations affected the severity of acute pancreatitis. In the cerulein-induced pancreatitis model, 93 and 129 metabolites were detected in the serum and pancreatic tissue, respectively. In the L-arginine-induced acute pancreatitis model, 120 and 133 metabolites were detected in the serum and pancreatic tissue, respectively. Among the metabolites, the concentrations of tricarboxylic acid (TCA) cycle intermediates and amino acids were altered in pancreatitis, and in pancreatic tissue, the levels of the intermediates involved in the initial part of the TCA cycle were increased and those of the intermediates involved in the latter part of the TCA cycle were decreased. Some metabolites exhibited similar changes in both pancreatitis mouse models, e.g., the levels of glutamic acid and O-phosphoethanolamine were significantly decreased in the pancreatic tissue. Supplementation with glutamic acid and O-phosphoethanolamine attenuated the severity of cerulein-induced acute pancreatitis. Our results suggest that GC/MS-based metabolomics is capable of accurately representing the status of acute pancreatitis, leading to the discovery of therapeutic agents for pancreatitis.Elsevier BV, 2012年06月, Archives of Biochemistry and Biophysics, 522(2) (2), 107 - 120, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- AIMS: Several screening methods have been applied for the early diagnosis of colorectal cancer, but most colorectal cancer patients are not diagnosed at a localized stage. In order to find novel biomarkers for the diagnosis of colorectal cancer, profiling of the serum levels of fatty acids, which are the main components of fats and are important factors for human metabolism, was performed using the sera of colorectal cancer patients. MATERIALS & METHODS: A total of 42 colorectal cancer patients and eight healthy volunteers participated in this study. The serum levels of fatty acids, including free fatty acids and esterified fatty acids, were evaluated by gas chromatography/mass spectrometry. Then, partial least squares discriminant analysis was performed on the basis of the serum fatty acids detected by gas chromatography/mass spectrometry. RESULTS: The serum levels of the nine fatty acids exhibited distinct differences between the colorectal cancer patients and healthy volunteers: the levels of four fatty acids were higher in the colorectal cancer patients than the healthy volunteers, and those of the other five fatty acids were lower. These changes were also observed at a very early clinical stage. Furthermore, the levels of very-long-chain fatty acids had a tendency to be increased in the sera of the colorectal cancer patients. CONCLUSIONS: The pathogenesis of colorectal cancer leads to changes in the composition of serum fatty acids including free fatty acids and esterified fatty acids. These results suggest that serum fatty acid profiling may be used as a novel diagnostic tool for early-stage colorectal cancer.Future Medicine Ltd, 2011年08月, Biomarkers in Medicine, 5(4) (4), 451 - 460, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2022年02月, CANCER SCIENCE, 113, 英語Stratification of high-risk individuals for pancreatic cancer by a plasma biomarker reflecting exocrine function研究発表ペーパー・要旨（国際会議）
- 2021年02月, CANCER SCIENCE, 112, 520 - 520, 英語Identification of Serum Biomarkers to Predict the Therapeutic-effects of Neo-CRT for Esophageal Cancer by Metabolomics研究発表ペーパー・要旨（国際会議）
- John Wiley and Sons Inc, 2021年, Journal of Gastroenterology and Hepatology (Australia), 英語書評論文,書評,文献紹介等
- 2021年, 胆と膵, 42(8) (8)膵癌,膵炎の病態解明と新規治療開発にむけた研究の最前線 膵癌のメタボローム解析によるバイオマーカーと新規治療の開発
- 2021年, 超音波医学 Supplement, 48良性胆膵疾患に対するInterventional EUSの検討
- 2021年, 日本消化器病学会雑誌(Web), 118治療困難胆管結石に対する電気衝撃波結石破砕術(EHL)の当院における現状と治療成績の検討
- 医学図書出版(株), 2020年04月, 胆と膵, 41(4) (4), 387 - 391, 日本語
- (株)東京医学社, 2020年03月, 消化器内視鏡, 32(3) (3), 385 - 390, 日本語
- 医学図書出版(株), 2020年03月, 胆と膵, 41(3) (3), 301 - 305, 日本語
- 2020年, 膵臓(Web), 35(3) (3)High risk stigmataを有するIPMN経過観察症例の予後からみたガイドラインの検証
- 2020年, 膵臓(Web), 35(3) (3)特異な画像を呈した膵神経内分泌癌の1例
- 2020年, 膵臓(Web), 35(3) (3)膵癌の予後におけるTLS(Tertiary lymphoid structure)の意義
- 2020年, 膵臓(Web), 35(3) (3)膵切除例を用いた早期慢性膵炎のEUS所見と背景膵の病理所見との対比
- 2020年, 膵臓(Web), 35(3) (3)IPMN併存膵癌とIPMN非併存膵癌の分子病理学的特徴と予後の相違
- 2020年, 日本消化器病学会雑誌(Web), 117肝門部領域胆管癌の術前診断におけるSpyGlassDSの有用性
- 2020年, 日本消化器病学会雑誌(Web), 117膵癌早期発見に向けての取り組み-当院における膵癌患者の診断前過去CT画像の検討-
- (株)東京医学社, 2019年11月, 消化器内視鏡, 31(11) (11), 1694 - 1699, 日本語
- (一財)日本消化器病学会, 2019年11月, 日本消化器病学会雑誌, 116(臨増大会) (臨増大会), A572 - A572, 日本語
- (株)東京医学社, 2019年11月, 消化器内視鏡, 31(11) (11), 1694 - 1699, 日本語【結石除去を極める】膵石 膵石除去における乳頭処置とその実際
- 日本消化器病学会-近畿支部, 2019年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 78 - 78, 日本語膵管内乳頭粘液性腺癌との鑑別が困難であった自己免疫性膵炎の1例
- 日本消化器病学会-近畿支部, 2019年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 89 - 89, 日本語正中弓状靱帯症候群に脾動脈瘤と膵体部腫瘤を合併した例
- 日本胆道学会, 2019年10月, 胆道, 33(3) (3), 528 - 528, 日本語
- 日本胆道学会, 2019年10月, 胆道, 33(3) (3), 585 - 585, 日本語
- 日本胆道学会, 2019年10月, 胆道, 33(3) (3), 644 - 644, 日本語
- 日本消化器病学会-近畿支部, 2019年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 78 - 78, 日本語膵管内乳頭粘液性腺癌との鑑別が困難であった自己免疫性膵炎の1例
- 日本消化器病学会-近畿支部, 2019年10月, 日本消化器病学会近畿支部例会プログラム・抄録集, 111回, 89 - 89, 日本語正中弓状靱帯症候群に脾動脈瘤と膵体部腫瘤を合併した例
- (一社)日本医用マススペクトル学会, 2019年08月, JSBMS Letters, 44(Suppl.) (Suppl.), 55 - 55, 日本語
- (NPO)日本高齢消化器病学会, 2019年07月, 日本高齢消化器病学会誌, 22(1) (1), 52 - 52, 日本語高齢者におけるERCP後膵炎のリスク解析
- 日本膵臓学会, 2019年06月, 膵臓, 34(3) (3), A49 - A50, 日本語
- 日本膵臓学会, 2019年06月, 膵臓, 34(3) (3), A166 - A167, 日本語
- 日本膵臓学会, 2019年06月, 膵臓, 34(3) (3), A209 - A210, 日本語
- 日本膵臓学会, 2019年06月, 膵臓, 34(3) (3), A303 - A303, 日本語
- (一社)日本消化器内視鏡学会, 2019年05月, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 901 - 901, 日本語悪性輸入脚狭窄に対する内視鏡的金属ステント留置術の検討
- (一社)日本消化器内視鏡学会, 2019年05月, Gastroenterological Endoscopy, 61(Suppl.1) (Suppl.1), 923 - 923, 日本語十二指腸乳頭部腫瘍に対する内視鏡的乳頭切除術(EP)後の病理学的評価と予後の検討
- (一財)日本消化器病学会, 2019年03月, 日本消化器病学会雑誌, 116(臨増総会) (臨増総会), A218 - A218, 日本語
- 日本消化器病学会-近畿支部, 2019年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 110回, 82 - 82, 日本語異所性膵を伴うHamartomatous inverted polypにより胃通過障害を来した一例
- 日本消化器病学会-近畿支部, 2019年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 110回, 90 - 90, 日本語術前に癌の確定診断困難であったT1a膵癌の1例
- 日本消化器病学会-近畿支部, 2019年02月, 日本消化器病学会近畿支部例会プログラム・抄録集, 110回, 113 - 113, 日本語Walled off necrosisに対して経皮的ドレナージ術を施行6年後に結腸皮膚瘻を形成した一例
- 2019年, 膵臓(Web), 34(3) (3)自己免疫性膵炎における造影CT平衡層のCT値によるステロイド治療後の膵萎縮の予測
- 2019年, 膵臓(Web), 34(3) (3)IPMN術後の残膵再発に関与する因子の検討-糖尿病の新規発症及び増悪の関連性-
- 2019年, 膵臓(Web), 34(3) (3)死亡の転帰となった薬剤性重症急性膵炎の一例
- 2019年, 日本消化器画像診断研究会プログラム・抄録集, 71st主膵管内に充満した粘液産生に乏しいpancreato-biliary type IPMNの1例
- 2019年, Gastroenterological Endoscopy (Web), 61(Supplement1) (Supplement1)十二指腸乳頭部腫瘍に対する内視鏡的乳頭切除術(EP)後の病理学的評価と予後の検討
- 2019年, 胆道(Web), 33(3) (3)胃および十二指腸球部に瘻孔を形成し,上部消化管内視鏡で胆管内を観察し得たIPNBと考えられる胆道腫瘍の一例
- 2019年, 胆道(Web), 33(3) (3)12年の経過観察ののち外科手術を行ったIntraductal papillary neoplasm of the bile duct(IPNB)の1例
- 2019年, 胆道(Web), 33(3) (3)抗PD-1抗体Pembrolizumabの免疫関連有害事象と考えられる胆管炎の1例
- 2019年, 膵臓(Web), 34(3) (3)膵石症に対する内視鏡治療を軸とした治療戦略
- 2019年, Gastroenterological Endoscopy (Web), 61(Supplement1) (Supplement1)悪性輸入脚狭窄に対する内視鏡的金属ステント留置術の検討
- 日本分子腫瘍マーカー研究会, 2019年01月, 日本分子腫瘍マーカー研究会誌, 34, 59 - 60, 日本語
- 科学評論社, 2018年12月, 消化器・肝臓内科 = Gastroenterology & hepatology / 消化器・肝臓内科編集委員会 編, 4(6) (6), 492 - 498, 日本語Peri-pancreatic fluid collection drainageにおける偶発症予防と対処—The management of adverse event for peri-pancreatic fluid collection drainage—特集 Interventional EUSの偶発症予防と対処
- (有)科学評論社, 2018年12月, 消化器・肝臓内科, 4(6) (6), 492 - 498, 日本語
- 2018年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 119 - 119, 英語Clinical utility of endoscopic therapy for bile leak associated with posthepatobiliary surgery研究発表ペーパー・要旨（国際会議）
- 2018年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 194 - 194, 英語Significance of pancreatic calcification on preoperative CT image of intraductal papillary mucinous neoplasm研究発表ペーパー・要旨（国際会議）
- 2018年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 33, 537 - 537, 英語The risk and benefit of preoperative pancreatic juice cytology under ERCP in patients with IPMNs研究発表ペーパー・要旨（国際会議）
- (株)アークメディア, 2018年11月, 肝・胆・膵, 77(5) (5), 957 - 963, 日本語
- 医学図書出版(株), 2018年11月, 胆と膵, 39(臨増特大) (臨増特大), 1179 - 1186, 日本語
- 日本分子腫瘍マーカー研究会, 2018年09月, 日本分子腫瘍マーカー研究会プログラム・講演抄録, 38回, 76 - 77, 日本語血中アポリポ蛋白A2アイソフォーム測定による膵がん検診の可能性
- 日本胆道学会, 2018年08月, 胆道, 32(3) (3), 422 - 422, 日本語
- 日本胆道学会, 2018年08月, 胆道, 32(3) (3), 490 - 490, 日本語
- (有)科学評論社, 2018年06月, 消化器・肝臓内科, 3(6) (6), 585 - 591, 日本語【重症急性膵炎とその合併症に対するマネジメント】Disconnected pancreatic duct syndromeの病態と治療
- 日本膵臓学会, 2018年05月, 膵臓, 33(3) (3), 336 - 336, 日本語
- 日本膵臓学会, 2018年05月, 膵臓, 33(3) (3), 413 - 413, 日本語
- 日本膵臓学会, 2018年05月, 膵臓, 33(3) (3), 580 - 580, 日本語
- (一社)日本消化器内視鏡学会, 2018年04月, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 670 - 670, 日本語IPMN診療におけるERCP下膵液細胞診の意義
- (一社)日本消化器内視鏡学会, 2018年04月, Gastroenterological Endoscopy, 60(Suppl.1) (Suppl.1), 842 - 842, 日本語自己免疫性膵炎に合併した胆管病変に対する内視鏡的胆道ドレナージ術の必要性
- (一財)日本消化器病学会, 2018年03月, 日本消化器病学会雑誌, 115(臨増総会) (臨増総会), A118 - A118, 日本語膵臓癌の新規スクリーニング法の開発と有効性の比較(IPMNを含む) 血液メタボロミクスによる膵がんスクリーニング法の開発記事・総説・解説・論説等（学術雑誌）
- 2018年01月, CANCER SCIENCE, 109, 704 - 704, 英語Potential usefulness of ApoA2 isoforms for screening and risk stratification of pancreatic cancer研究発表ペーパー・要旨（国際会議）
- (有)科学評論社, 2017年12月, 消化器・肝臓内科, 2(6) (6), 596 - 603, 日本語【膵疾患に対する内視鏡治療の新展開】膵頭十二指腸切除術後の膵管空腸吻合部狭窄に対するInterventional EUS記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 医学図書出版(株), 2017年10月, 胆と膵, 38(臨増特大) (臨増特大), 1021 - 1028, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)東京医学社, 2017年10月, 消化器内視鏡, 29(10) (10), 1910 - 1915, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 医学図書出版(株), 2017年10月, 胆と膵, 38(10) (10), 1221 - 1226, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本消化器内視鏡学会, 2017年09月, Gastroenterological Endoscopy, 59(Suppl.2) (Suppl.2), 2140 - 2140, 日本語内視鏡的乳頭切除術後に診断された早期十二指腸乳頭部癌の予後
- (一社)日本消化器内視鏡学会, 2017年09月, Gastroenterological Endoscopy, 59(Suppl.2) (Suppl.2), 2182 - 2182, 日本語IPMN由来浸潤癌および併存膵癌におけるEUS背景膵所見の有用性
- (有)科学評論社, 2017年09月, 消化器・肝臓内科, 2(3) (3), 282 - 293, 日本語【Interventional EUSの最新情報-適応、手技、デバイス-】Pancreatic fluid collection(膵・膵周囲液体貯留)に対するInterventional EUS記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 日本胆道学会, 2017年08月, 胆道, 31(3) (3), 502 - 502, 日本語
- 日本胆道学会, 2017年08月, 胆道, 31(3) (3), 509 - 509, 日本語
- 日本胆道学会, 2017年08月, 胆道, 31(3) (3), 610 - 610, 日本語
- 日本膵臓学会, 2017年05月, 膵臓, 32(3) (3), 374 - 374, 日本語
- 日本膵臓学会, 2017年05月, 膵臓, 32(3) (3), 414 - 414, 日本語
- 医学図書出版(株), 2016年11月, 胆と膵, 37(臨増特大) (臨増特大), 1121 - 1129, 日本語
- 2016年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 233 - 233, 英語New method of sphincter of Oddi manometry and therapeutic effect of EST in patients with sphincter of Oddi disorder研究発表ペーパー・要旨（国際会議）
- (株)日本メディカルセンター, 2016年11月, 臨床消化器内科, 31(13) (13), 1749 - 1754, 日本語記事・総説・解説・論説等（学術雑誌）
- (株)アークメディア, 2016年10月, 肝・胆・膵, 73(4) (4), 541 - 550, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本消化器内視鏡学会, 2016年04月, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 615 - 615, 日本語悪性輸入脚狭窄に対する内視鏡的消化管金属ステント留置術の検討
- (一社)日本消化器内視鏡学会, 2016年04月, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 706 - 706, 日本語乳頭部病変の深達度診断にEUSとIDUSはいずれも必要なのか 当院における乳頭部病変の深達度診断に関する検討
- (一社)日本消化器内視鏡学会, 2016年04月, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 707 - 707, 日本語造影ハーモニックEUSを用いた膵の小腫瘤性病変の診断
- (一社)日本消化器内視鏡学会, 2016年04月, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 715 - 715, 日本語PEP高リスク群へのERCPでは何に留意すべきか 膵炎既往群における手技側因子の解析
- (一社)日本消化器内視鏡学会, 2016年04月, Gastroenterological Endoscopy, 58(Suppl.1) (Suppl.1), 774 - 774, 日本語当院における80歳以上の高齢者におけるERCP後膵炎のリスク解析
- (一財)日本消化器病学会, 2016年03月, 日本消化器病学会雑誌, 113(臨増総会) (臨増総会), A279 - A279, 日本語背景膵萎縮変化がIPMNの悪性予測因子となる-IPMNにおける膵実質評価(EUS)の有用性
- (株)メディカルドゥ, 2015年11月, 遺伝子医学MOOK, (29) (29), 89 - 93, 日本語【オミックスで加速するがんバイオマーカー研究の最新動向 リスク評価、早期診断、治療効果・予後予測を可能にする新しいバイオマーカー】(第1章)オミックス解析技術 最近のオミックス解析技術の進歩 メタボローム記事・総説・解説・論説等（学術雑誌）
- (一財)日本消化器病学会, 2015年09月, 日本消化器病学会雑誌, 112(臨増大会) (臨増大会), A774 - A774, 日本語疾患メタボロミクスの現状と将来 血清メタボロミクスによる早期大腸がんスクリーニングシステムの開発
- 日本胆道学会, 2015年08月, 胆道, 29(3) (3), 656 - 656, 日本語
- 日本膵臓学会, 2015年05月, 膵臓, 30(3) (3), 412 - 412, 日本語
- 日本膵臓学会, 2015年05月, 膵臓, 30(3) (3), 529 - 529, 日本語
- (株)医学書院, 2015年05月, 臨床検査, 59(5) (5), 405 - 410, 日本語記事・総説・解説・論説等（学術雑誌）
- (一社)日本消化器内視鏡学会, 2015年04月, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 742 - 742, 日本語膵腫瘤性病変の診断における造影ハーモニックEUSの有用性
- (一社)日本消化器内視鏡学会, 2015年04月, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 762 - 762, 日本語肝門部胆管癌に対する術前胆道ドレナージ中の急性胆管炎の現状と対策
- (一社)日本消化器内視鏡学会, 2015年04月, Gastroenterological Endoscopy, 57(Suppl.1) (Suppl.1), 769 - 769, 日本語選択的胆道挿管困難例に対するUneven Double Lumen Cannulaを用いた新しいアプローチ
- (公社)日本超音波医学会, 2015年04月, 超音波医学, 42(Suppl.) (Suppl.), S433 - S433, 日本語造影超音波は肝腫瘍以外の消化器疾患に必要か? 小膵癌の診断における造影ハーモニックEUSの臨床的有用性
- (公社)日本超音波医学会, 2015年03月, 超音波医学, 42(2) (2), 271 - 271, 日本語膵に腫瘤を形成した髄外性形質細胞腫の一例
- (一財)日本消化器病学会, 2015年03月, 日本消化器病学会雑誌, 112(臨増総会) (臨増総会), A379 - A379, 日本語ガイドワイヤー型圧モニターを用いた十二指腸乳頭括約筋圧測定
- (株)先端医学社, 2015年02月, G.I.Research, 23(1) (1), 46 - 51, 日本語記事・総説・解説・論説等（学術雑誌）
- 2015年, 日本消化器画像診断研究会プログラム・抄録集, 63rd多発肝転移をきたした膵Solid Pseudopapillary Neoplasmの1切除例
- 2014年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, 43 - 43, 英語Effectiveness of self-expandable metal stent for afferent loop obstruction caused by cancer recurrence after pancreaticoduodenectomy研究発表ペーパー・要旨（国際会議）
- (一社)日本医用マススペクトル学会, 2014年09月, JSBMS Letters, 39(Suppl.) (Suppl.), 66 - 66, 日本語GCMSを用いた心不全バイオマーカー探索
- (一財)日本消化器病学会, 2014年09月, 日本消化器病学会雑誌, 111(臨増大会) (臨増大会), A803 - A803, 日本語微小膵癌発見のための検査・診断法 血清メタボローム解析による膵癌スクリーニング法の有用性
- (一財)日本消化器病学会, 2014年09月, 日本消化器病学会雑誌, 111(臨増大会) (臨増大会), A942 - A942, 日本語胆管外病変のないIgG4関連硬化性胆管炎に対する肝生検の有用性の検討
- {MDPI} {AG}, 2014年07月07日, Metabolites, 4(3) (3), 547 - 571, 英語[査読有り]
- (一社)日本癌治療学会, 2014年06月, 日本癌治療学会誌, 49(2) (2), 429 - 430, 日本語バイオマーカー研究の最前線 血清メタボロミクスによる新規バイオマーカーの開発
- (一財)日本消化器病学会, 2014年03月, 日本消化器病学会雑誌, 111(臨増総会) (臨増総会), A228 - A228, 日本語消化管再建後胆膵疾患症例に対するダブルバルーン内視鏡によるアプローチの現状と課題
- (株)アークメディア, 2014年03月, 肝・胆・膵, 68(3) (3), 409 - 413, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)ニュー・サイエンス社, 2014年03月, 細胞, 46(3) (3), 107 - 110, 日本語記事・総説・解説・論説等（学術雑誌）
- (株)東京医学社, 2014年02月, 消化器内視鏡, 26(2) (2), 280 - 288, 日本語記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2014年, Bios, 19(2) (2), 7 - 8, 日本語（Key Word）メタボローム解析による消化器がんのバイオマーカー探索記事・総説・解説・論説等（学術雑誌）
- (株)先端医学社, 2013年12月, G.I.Research, 21(6) (6), 569 - 573, 日本語記事・総説・解説・論説等（学術雑誌）
- 日本癌学会, 2013年10月, 日本癌学会総会記事, 72回, 58 - 58, 英語バイオマーカー研究の進展 血清メタボロミクスによる膵がんスクリーニング(Recent Advance in Cancer Biomarker Research Serum metabolomics as a screening method for pancreatic cancer)
- (一社)日本医用マススペクトル学会, 2013年08月, JSBMS Letters, 38(Suppl.) (Suppl.), 73 - 73, 日本語血清メタボローム解析を用いた新規膵がん診断法の開発
- 2013年05月, GASTROENTEROLOGY, 144(5) (5), S657 - S657, 英語Serum Metabolomics As the Diagnostic Application for Early Diagnosis of Pancreatic Cancer研究発表ペーパー・要旨（国際会議）
- (一財)日本消化器病学会, 2013年02月, 日本消化器病学会雑誌, 110(臨増総会) (臨増総会), A299 - A299, 日本語メタボロミクスを用いた膵炎治療薬の探索記事・総説・解説・論説等（その他）
- (一財)日本消化器病学会, 2013年02月, 日本消化器病学会雑誌, 110(臨増総会) (臨増総会), A74 - A74, 日本語消化器疾患における新規分子マーカー ガスクロマトグラフィー質量分析を用いた血清メタボロミクスによる新規大腸がん診断システムの開発会議報告等
- 島津評論編集部 ; 1940-, 2013年, 島津評論, 70(3) (3), 117 - 121, 日本語ガスクロマトグラフィ質量分析を用いた血清メタボロミクスによる膵がんバイオマーカー探索
- (一社)日本癌治療学会, 2011年09月, 日本癌治療学会誌, 46(2) (2), 638 - 638, 日本語StageII/III進行食道癌患者における化学放射線療法の長期予後予測遺伝子型について
- (一社)日本消化器内視鏡学会, 2011年03月, Gastroenterological Endoscopy, 53(Suppl.1) (Suppl.1), 924 - 924, 日本語Flush knifeを用いた乳頭プレカット手技
- (一財)日本消化器病学会, 2011年03月, 日本消化器病学会雑誌, 108(臨増総会) (臨増総会), A219 - A219, 日本語血清メタボロミクスを用いた膵がん新規診断法の開発
- 医学図書出版, 2020年04月胆と膵 【10mm以下膵癌の診断に挑む】膵癌早期発見をめざしたバイオマーカー探索と検診への展望(解説/特集)
- 医学図書出版, 2020年03月胆と膵【内視鏡下採取検体を用いた膵疾患バイオマーカー探索】EUS-FNA(膵液を含む)を用いたメタボローム解析の展望
- その他, 日本メディカルセンター, 2016年12月, 日本語臨牀消化器内科 / 生物学的マーカーによる早期の膵癌の診断学術書
- その他, アークメディア, 2014年03月, 日本語肝胆膵 / メタボローム解析による膵がんバイオマーカー探索一般書・啓蒙書
- その他, 先端医学社, 2013年12月, 日本語G.I.Research / 質量分析による消化器疾患バイオマーカーの同定一般書・啓蒙書
- その他, 島津製作所, 2013年03月, 日本語島津評論 / ガスクロマトグラフィ質量分析を用いた血清メタボロミクスによる膵がんバイオマーカー探索その他
- 25th United European Gastroenterology Week (UEGW2017), 2017年11月, 英語, United European Gastroenterology Week, Barcelona, Spain, 国際会議Validation of serum/plasma metabolomic biomarkers against pancreatic cancer by quantitative targeted GC/MS/MSポスター発表
- UEGW 2017, 2017年11月, 英語, Organizing committee of the 2017 United European gastroenterology Week, バルセロナ, スペイン, 国際会議The predictor’s factor of step up approach using EUS-guided transmural drainage for walled-off necrosisポスター発表
- 第53回日本胆道学会学術集会, 2017年09月, 日本語, 日本胆道学会, 山形, 国内会議切除企図肝門部胆道癌に対する術前胆道ドレナージの検討口頭発表（一般）
- 第53回日本胆道学会学術集会, 2017年09月, 日本語, 日本胆道学会, 山形, 国内会議十二指腸乳頭部腫瘍に対する内視鏡的乳頭切除術の成績口頭発表（一般）
- 第42回日本医用マススペクトル学会年会, 2017年09月, 日本語, 日本医用マススペクトル学会, 千代田区, 国内会議脂質分析による非アルコール性脂肪性肝炎病態関連因子の同定ポスター発表
- APDW2017, 2017年09月, 英語, Organizing committee of the 2017 Asia pacific Digestive Week, 香港, 中国, 国際会議Validation of Rome IV criteria for sphincter of Oddi disorder and therapeutic effect of endoscopic sphincterotomy by using the new method of sphincter of Oddi manometryポスター発表
- SFC Asia 2017, 2017年07月, 英語, Green Chemistry Group, Osaka, Japan, 国際会議The Use of Online SFE-SFC/MS/MS to Analyze Disease Biomarkers in Dried Serum Spots.ポスター発表
- 第98回日本消化器内視鏡学会近畿地方会, 2017年06月, 日本語, 日本消化器病学会, 神戸, 国内会議内視鏡的十二指腸乳頭切除術の偶発症に対する予防とトラブルシューティングシンポジウム・ワークショップパネル（公募）
- 第98回日本消化器内視鏡学会近畿支部, 2017年06月, 日本語, 神戸大学, 神戸, 国内会議総胆管に逸脱した多発性胆嚢腫瘍の一例口頭発表（一般）
- 第95回日本消化器内視鏡学会近畿支部例会, 2015年11月, 日本語, 日本内視鏡学会, 大阪, 国内会議肝門部胆管癌に対する術前胆道ドレナージにおけるインサイドステントの検討シンポジウム・ワークショップパネル（公募）
- 第23回日本消化器関連学会週間, 2015年10月, 日本語, Japan Digestive Discase Week, 東京, 国内会議血清メタボロミクスによる早期大腸がんスクリーニングシステムの開発口頭発表（一般）
- JDDW2015 第57回日本消化器病学会大会, 2015年10月, 日本語, 日本消化器病学会, 東京, 国内会議血清メタボロミクスによる早期大腸がんスクリーニングシステムの開発シンポジウム・ワークショップパネル（公募）
- 日本消化器画像診断研究会, 2015年09月, 日本語, 日本消化器画像診断研究会, 鎌倉, 国内会議多発肝転移をきたした膵Solid Pseudopapillary Neoplasmの1切除例口頭発表（一般）
- 第51回日本胆道学会学術集会, 2015年09月, 日本語, 日本胆道学会, 宇都宮, 国内会議肝門部胆管癌に対する術前胆道ドレナージの検討ポスター発表
- 第46回日本膵臓学会大会, 2015年06月, 日本語, 日本膵臓学会, 名古屋, 国内会議多発肝転移を伴ったSolid-pseudopapillary neoplasm(SPN)の1例ポスター発表
- 第46回日本膵臓学会大会, 2015年06月, 日本語, 日本膵臓学会, 名古屋, 国内会議小膵腫瘤性病変の診断における造影ハーモニックEUSの有用性口頭発表（一般）
- 第46回日本膵臓学会大会, 2015年06月, 日本語, 日本膵臓学会, 名古屋, 国内会議MCNとの鑑別が困難であった膵内副脾に発生したepidermoid cystの一例ポスター発表
- 第89回日本消化器内視鏡学会総会, 2015年05月, 日本語, 日本内視鏡学会, 名古屋, 国内会議膵腫瘤性病変の診断における造影ハーモニックEUSの有用性口頭発表（一般）
- 第89回日本消化器内視鏡学会総会, 2015年05月, 日本語, 日本内視鏡学会, 名古屋, 国内会議選択的胆道挿管困難例に対するUneven Double Lumen Cannulaを用いた新しいアプローチ口頭発表（一般）
- 日本超音波医学会第88回学術集会, 2015年05月, 日本語, 日本超音波医学会, 東京, 国内会議小膵癌の診断における造影ハーモニックEUSの臨床的有用性シンポジウム・ワークショップパネル（公募）
- 第89回日本消化器内視鏡学会総会, 2015年05月, 日本語, 日本内視鏡学会, 名古屋, 国内会議肝門部胆管癌に対する術前胆道ドレナージ中の急性胆管炎の現状と対策口頭発表（一般）
- 第101回日本消化器病学会総会, 2015年04月, 日本語, 日本消化器病学会, 仙台, 国内会議ガイドワイヤー型圧モニターを用いた十二指腸乳頭括約筋圧測定口頭発表（一般）
- メディカルジャパン2015大阪, 2015年02月, 日本語, リード エグジビション ジャパン株式会社, 大阪, 国内会議微量の血液からのメタボロミクスによる疾患診断公開講演，セミナー，チュートリアル，講習，講義等
- 日本超音波医学会第41回関西地方会学術集会, 2014年11月, 日本語, 日本超音波医学会, 京都, 国内会議膵に腫瘤を形成した髄外性形質細胞腫の一例口頭発表（一般）
- Asian Pacific Digestive Disease Week 2014, 2014年11月, 英語, APDW Federation, Bali, Indonesia, 国際会議Effectiveness of self-expandable metal stent for afferent loop obstruction caused by cancer recurrence after pancreatico-duodenectomy口頭発表（一般）
- 第88回日本消化器内視鏡学会総会, 2014年10月, 日本語, 日本消化器内視鏡学会, 神戸, 国内会議膵頭十二指腸切除術後の悪性輸入脚狭窄に対する内視鏡的消化管金属ステント治療の有用性ポスター発表
- 第88回日本消化器内視鏡学会総会, 2014年10月, 日本語, 日本消化器内視鏡学会, 神戸, 国内会議膵腫瘤性病変における造影ハーモニックEUSの有用性ポスター発表
- JDDW 2014, 2014年10月, 日本語, 日本消化器学会関連機構, 福岡, 国内会議膵腫瘤性病変における造影ハーモニックEUSの有用性ポスター発表
- 第56回日本消化器病学会大会, 2014年10月, 日本語, 日本消化器病学会, 神戸, 国内会議胆管外病変のないIgG4関連硬化性胆管炎に対する肝生検の有用性の検討ポスター発表
- 第56回日本消化器病学会大会, 2014年10月, 日本語, 日本消化器病学会, 神戸, 国内会議血清メタボローム解析による膵癌スクリーニング法の有用性シンポジウム・ワークショップパネル（公募）
- 第61回日本消化器画像診断研究会, 2014年09月, 日本語, 日本消化器画像診断研究会, 奈良, 国内会議重症急性膵炎を契機に発見された膵管内腫瘍の1例口頭発表（一般）
- 第50回日本胆道学会学術集会, 2014年09月, 日本語, 日本胆道学会, 東京, 国内会議管状乳頭状増殖を呈した粘液低産生IPNBの1例ポスター発表
- 第52回日本癌治療学会学術集会, 2014年08月, 日本語, 日本癌治療学会, 横浜, 国内会議血清メタボロミクスによる新規バイオマーカーの開発[招待有り]シンポジウム・ワークショップパネル（指名）
- 第45回日本膵臓学会大会, 2014年07月, 日本語, 日本膵臓学会, 福岡, 国内会議膵腫瘍の診断における造影EUSの有用性[招待有り]口頭発表（招待・特別）
- 第45回日本膵臓学会大会, 2014年07月, 日本語, 日本膵臓学会, 北九州, 国内会議早期膵癌診断における造影ハーモニックEUSの有用性口頭発表（一般）
- 第45回日本膵臓学会大会, 2014年07月, 日本語, 日本膵臓学会, 北九州, 国内会議血清メタボロミクスによる膵癌スクリーニング法の検討口頭発表（一般）
- 第45回日本膵臓学会大会, 2014年07月, 日本語, 日本膵臓学会, 北九州, 国内会議Walled off necrosisに対するEUSガイド下治療口頭発表（一般）
- 第45回日本膵臓学会大会, 2014年07月, 日本語, 日本膵臓学会, 小倉, 国内会議Walled-off necrosis(WON)に対するEUSガイド下治療口頭発表（一般）
- 第87回日本消化器内視鏡学会総会, 2014年05月, 日本語, 日本消化器内視鏡学会, 福岡, 国内会議当院におけるEST+EPLBDの現状と問題点ポスター発表
- 第87回日本消化器内視鏡学会総会, 2014年05月, 日本語, 日本消化器内視鏡学会, 福岡, 国内会議当院での総胆管結石治療におけるEPLBD法の現状と問題点ポスター発表
- 第100回日本消化器病学会総会, 2014年04月, 日本語, 日本消化器病学会, 東京, 国内会議消化管再建後胆膵疾患症例に対するダブルバルーン内視鏡によるアプローチの現状と課題口頭発表（一般）
- JDDW2013, 2013年10月, 日本語, 日本消化器病学会、日本消化器内視鏡学会, 東京, 国内会議内視鏡的乳頭切除術翌日のsecond lookは有用か？ポスター発表
- 第72回日本癌学会総会, 2013年10月, 英語, 日本癌学会, 横浜, Background: To improve the prognosis of pancreatic cancer patients, more sensitive screening method are needed. We applied serum metabolomics as a diagnostic method for pancreatic cancer. Methods: Sera from pancreatic cancer patients (PC), healthy volunteers (HV), and chronic pancreatitis patients (CP) were collected at multiple institutions. The PC and HV were randomly allocat, 国内会議Serum metabolomics as a screening method for pancreatic cancerシンポジウム・ワークショップパネル（公募）
- 日本消化器病学会近畿支部第99回例会, 2013年09月, 日本語, 日本消化器病学会, 大阪, 国内会議膵石による主膵管拡張を伴う慢性膵炎に発生した分枝型IPMCの1例その他
- 日本消化器病学会近畿支部第99回例会, 2013年09月, 日本語, 日本消化器病学会近畿支部, 大阪, 国内会議膵腫瘍の診断における造影EUSの有用性シンポジウム・ワークショップパネル（公募）
- 第24回消化器癌発生学会総会, 2013年09月, 日本語, 日本消化器癌発生学会, 金沢, 背景：膵がん患者の予後を改善するためには、早期の膵がんに対しても精度が高い血清診断法が必要である。我々は、膵がんの診断における血清メタボロミクスの有用性について検討した。方法：膵がん患者（PC）、健常者（HV）、および、慢性膵炎患者（CP）の血清を多施設から収集した。PCとHVは無作為に学習セットと検証セットに割り当てた。全てのCPは検証セットに当てた。学習セットと検証セットのそれぞれにおいて、対象者の血清代謝物を、ガスクロマトグラフ質量分析計を用いた解析システムによって分析した。学習セット解析においては、多重ロジスティック回帰分析を用いて膵がんの診断予測式を構築し、その感度、特異度を評価した。さらに、検証セット解析においては、構築した診断予測式の感度と特異度を、従来の腫瘍マーカーと比較することで検証した。結果：PC43例、HV42例からなる学習セッ, 国内会議血清メタボロミクスによる膵がんに対する新たな診断的アプローチシンポジウム・ワークショップパネル（公募）
- 第38回日本医用マススペクトル学会年会, 2013年09月, 日本語, 日本医用マススペクトル学会, 神戸, 【目的】膵がんは非常に進行が早く、患者の多くは治癒が見込めない転移・浸潤を伴う段階へ進行した状態で発見される。現在、用いられている検査方法では早期の膵がんを効率よく発見することはできず、また、偽陽性が問題となる場合も多い。よって、より正確かつ効率的に早期の膵がんを発見する手法が強く求められている。そこで我々は、膵がんの診断における血清メタボロミクスの有用性について検討した。【方法】膵がん患者（PC）、健常者（HV）、および、慢性膵炎患者（CP）について、それぞれ85例、83例、23例の血清を多施設から収集した。そのうち、PC43例と、これに年齢と性別を適合させたHV42例を抽出し、学習セットに割り当てた。残りPC42例、HV41例、CP23例を検証セットに割り当てた。学習セットと検証セットのそれぞれにおいて、対象者の血清代謝物を、ガスクロマトグラフ質, 国内会議血清メタボローム解析を用いた新規膵がん診断法の開発ポスター発表
- the 12th Human Proteome Organization Congress, 2013年09月, 英語, Human Proteome Organization, Yokohama, Japan, Background: To improve the prognosis of pancreatic cancer patients, more sensitive serum screening methods with high accuracy are needed. We applied serum metabolomics as a diagnostic tool for pancreatic cancer.Methods: Sera from pancreatic cancer patients (PC), healthy volunteers (HV), and chronic pancreatitis patients (CP) were collected at multiple institutions. The PC and H, 国際会議Serum metabolomics-based screening method for pancreatic cancerポスター発表
- AGA-DDW2013, 2013年05月, 英語, American Gastroenterological Association, Orland, FL, USA, Background: Pancreatic cancer is characterized by rapid tumor progression and early metastasis. Although the only curative treatment is surgical resection, there is no efficient diagnostic method for early detection of it at resectable stage.Purpose: To develop more efficient diagnostic method for pancreatic cancer, we used serum metabolomics as the novel diagnostic application, 国際会議Serum metabolomics as the diagnostic application for early diagnosis of pancreatic cancerポスター発表
- 第99回日本消化器病学会総会, 2013年03月, 日本語, 日本消化器病学会, 鹿児島, 国内会議メタボロミクスを用いた膵炎治療薬の探索口頭発表（一般）
- 第99回日本消化器病学会総会, 2013年03月, 日本語, 日本消化器病学会, 鹿児島, 国内会議ガスクロマトグラフィー質量分析を用いた血清メタボロミクスによる新規大腸がん診断システムの開発シンポジウム・ワークショップパネル（公募）
- The 2nd JSGE International Topic Conference, 2013年03月, 英語, JSGE, 鹿児島, Background: To improve the prognosis of pancreatic cancer patients, more accurate serum diagnostic methods which could discriminate cancer from chronic inflammation are required. We used serum metabolomics as a diagnostic method for pancreatic cancer.Methods: Sera from pancreatic cancer patients (PC), healthy volunteers (HV), and chronic pancreatitis patients (CP) were collecte, 国際会議A Serum Metabolomic Analysis-based Diagnostic Approach to Pancreatic Cancer and Chronic Pancreatitisポスター発表
- 第99回日本消化器病学会総会, 2013年03月, 日本語, 日本消化器病学会, 鹿児島, 国内会議APC遺伝子変異が大腸癌の代謝プロファイルに与える影響についての検討口頭発表（一般）
- 第58回日本臨床検査医学会学術集会, 2011年11月, 日本語, 岡山, 国内会議リウマトイド因子(RF)標準化のガイドライン（日本臨床検査標準化協議会JCCLS認証）口頭発表（一般）
- 第49回日本癌治療学会学術集会, 2011年10月, 日本語, 日本癌治療学会, 名古屋, 国内会議StageII/III進行食道癌患者における化学放射線療法の長期予後予測遺伝子型について口頭発表（一般）
- 9th International Congress on Coronary Artery Disease, 2011年10月, 英語, Venice, Italy, 国際会議CORONARY SPASM INJURES CORONARY LESIONS OF WHHLMI RABBITS.ポスター発表
- 第95回日本消化器病学会近畿支部例会, 2011年08月, 日本語, 日本消化器病学会, 大阪, 国内会議膵管ブラシ細胞診が診断に有用であった分枝型IPMC由来微小浸潤癌の一例口頭発表（一般）
- 日本消化器病学会近畿支部 第95回例会, 2011年08月, 日本語, 日本消化器病学会, 大阪, 国内会議膵管ブラシ細胞診が診断に有効であった分枝型IPMC由来微小浸潤癌の一例口頭発表（一般）
- 第95回日本消化器病学会近畿支部例会, 2011年08月, 日本語, 日本消化器病学会, 大阪, 国内会議超音波内視鏡下穿刺吸引生検(EUS-FNAB)にて診断し得た十二指腸原発悪性リンパ腫の1例口頭発表（一般）
- 第95回日本消化器病学会近畿支部例会, 2011年08月, 日本語, 日本消化器病学会, 大阪, 国内会議経乳頭的ドレナージ術が奏功した胃切除後の巨大膵仮性嚢胞の2例口頭発表（一般）
- 第81回日本消化器内視鏡学会総会, 2011年08月, 日本語, 日本消化器内視鏡学会, 名古屋, 国内会議Flush knifeを用いた乳頭プレカット手技口頭発表（一般）
- The 43rd Annual Scientific Meeting of the Japanese Atherosclerosis Society., 2011年07月, 日本語, 日本動脈硬化学会, 札幌, 国内会議Developement of an Animal Model for coronary spastic anginaポスター発表
- 4th International Rabbit Biotechnology Meeting, 2011年06月, 英語, Agricultural Biotechnology Center, Hungary, Budapest, Humgary, 国際会議WHHLMI Rabbits with Coronary Lesions are a good Animal Model for Coronary Spastic Anginaポスター発表
- 第97回日本消化器病学会総会, 2011年05月, 日本語, 日本消化器病学会, 東京, 国内会議血清メタボロミクスを用いた 膵がん新規診断法の開発口頭発表（一般）
- 第21回国際臨床化学臨床検査医学会, 2011年05月, 英語, ベルリン, ドイツ, 国際会議Harmonization of Cutoff Value for Rheumatoid Factor (RF) as 15 Iu/Ml at Positive in 5% of Healthy Subjects.ポスター発表