研究活動情報

• 2025年07月 神戸大学医学部放射線科同門会, 優秀論文賞, Differentiating multiple sclerosis and neuromyelitis optica spectrum disorders through pontine trigeminal nerve lesions: A comparative MRI study

• Intracranial solitary fibrous tumor with multiloculated cystic change: A case report.

  Yasuyuki Kojita, Tomonori Kanda, Shiho Yokoo, Tomoka Kanai, Hiroaki Sanada, Mari Idei, Hiroaki Nagashima, Naoe Jimbo, Takeaki Ishihara, Kazunari Ishii, Takamichi Murakami

  Intracranial solitary fibrous tumor (SFT) is a mesenchymal neoplasm that typically appears as a solid mass, whereas cases with predominantly cystic change are extremely uncommon. We report a case of intracranial SFT presenting as a cystic lesion. A 67-year-old woman presented with progressive memory impairment and gait instability over a 6-month period. CT and MRI revealed a mass located along the falx cerebri, composed predominantly of cystic components. The patient underwent surgical tumor resection, and histopathological examination confirmed the diagnosis of SFT, CNS WHO grade 2. Postoperative radiotherapy was administered, and no evidence of recurrence was observed during a 2-year follow-up period. Because SFT is an aggressive tumor with a high risk of recurrence and distant metastasis, accurate diagnosis is essential for appropriate treatment planning and postoperative surveillance. Therefore, SFT should be included in the differential diagnosis of intracranial tumors with cystic morphology.

  2026年11月, Radiology case reports, 21(11) (11), 5431 - 5435, 英語, 国際誌

  研究論文（学術雑誌）


• Regional differences in 18F-flutemetamol accumulation between amyloid-positive and -negative brains using high-resolution dedicated head PET scanner.

  Yasuyuki Kojita, Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Atsushi K Kono, Kazushi Hanada, Kazumasa Saigoh, Mamoru Hashimoto, Takashi Kato, Akinori Nakamura

  OBJECTIVE: To investigate regional 18F-flutemetamol accumulation differences between amyloid-positive (Aβ⁺) and amyloid-negative (Aβ⁻) brains, particularly in cerebral white matter, using a dedicated head PET (dhPET) scanner. METHODS: This retrospective study included 38 consecutive participants who underwent ¹⁸F-flutemetamol PET using a high-resolution dhPET scanner (SET-5002, Shimadzu). Participants were classified as Aβ⁺ or Aβ⁻ based on cortical uptake patterns. Voxels of interest were anatomically defined using OpenMAP-T1, an MRI-based automated brain parcellation software, and merged into 33 regions for SUVR calculation. SUVRs were calculated using the Centiloid whole cerebellar VOIs as the reference region. Group comparisons were assessed using two-way repeated-measures ANOVA, followed by Mann-Whitney U tests with false discovery rate correction. Age and MMSE were compared using nonparametric tests, and gender using Fisher's exact test. RESULTS: The Aβ⁺ (n = 25) and Aβ⁻ (n = 13) groups did not differ in age, gender, or MMSE. ANOVA revealed significant effects of group, VOI, and group×VOI interaction (all p < 0.001). After FDR correction, SUVRs were significantly higher in the Aβ⁺ group across widespread cortical gray matter, cerebral white matter, and subcortical structures, as well as in the choroid plexus and cerebellar gray matter (all q < 0.05). No significant differences were observed in cerebellar white matter, cerebellar peduncle, or brainstem regions. CONCLUSION: High-resolution dhPET revealed significantly higher SUVRs in Aβ⁺ compared with Aβ⁻ subjects in supratentorial structures, including cerebral white matter, and in cerebellar gray matter.

  2026年08月, Annals of nuclear medicine, 英語, 国内誌

  研究論文（学術雑誌）


• Stage-specific regional distribution of amyloid and tau deposition across the Alzheimer's disease continuum revealed by tau-to-amyloid ratio imaging.

  Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Yasuyuki Kojita, Atsushi Kono, Hayato Kaida, Takashi Nihashi, Keita Sakurai, Takashi Kato, Akinori Nakamura

  BACKGROUND: Amyloid-β and tau deposition follow distinct spatial and temporal trajectories across the Alzheimer's disease (AD) continuum. Amyloid accumulation occurs early in the disease course, whereas tau pathology is more closely associated with neurodegeneration and clinical progression. Characterizing stage-specific regional divergence between amyloid and tau deposition may refine biomarker-based disease staging and improve prognostic assessment. METHODS: We analyzed participants from the BATON study who underwent amyloid PET with 18F-flutemetamol, tau PET with 18F-MK-6240, and 3D MRI within a three-month interval. Participants were classified into cognitively normal amyloid-negative controls (CNA, n = 101) and the AD continuum (n = 102), comprising preclinical AD (PCA, n = 47), mild cognitive impairment due to AD (MCA, n = 24), and AD dementia (ADD, n = 31). Standardized uptake value ratios (SUVRs) were calculated using the Centiloid and CenTauR frameworks, and voxel-wise tau-to-amyloid ratio (TAR) images were generated. Voxel-wise and region-of-interest analyses were performed to compare regional patterns of amyloid deposition, tau accumulation, and TAR across disease stages. RESULTS: Amyloid deposition was already widespread at the PCA stage, involving the frontal, posterior cingulate/precuneus, and temporal cortices. In contrast, tau deposition in PCA was largely confined to the medial temporal lobe. With progression to MCA and ADD, tau burden increased substantially and extended to the lateral temporal, parietal, and frontal cortices. TAR analysis demonstrated high values in the medial temporal cortex at the PCA stage, followed by decreasing TAR in frontal regions during MCA and a tau-dominant neocortical pattern in ADD. CONCLUSIONS: Amyloid and tau exhibit distinct and stage-dependent regional dissociation across the AD continuum. TAR imaging effectively captures this divergence, reflecting early medial temporal tau predominance and subsequent neocortical tau expansion. These findings support the utility of integrated amyloid-tau PET metrics for refined disease staging and longitudinal therapeutic monitoring.

  2026年05月, European journal of nuclear medicine and molecular imaging, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Off-target binding of 18F-MK-6240 tau PET imaging demonstrated by high spatial resolution dedicated brain PET scanner.

  Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Atsushi Kono, Kenji Ishii, Takashi Kato, Akinori Nakamura

  2026年02月, Annals of nuclear medicine, 英語, 国内誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Development and evaluation of a deep learning-assisted diagnostic support system for radiographer preliminary clinical evaluation of intracranial hemorrhage.

  Kazuma Tsukamoto, Mizuho Nishio, Ryo Kurosaki, Yasuyuki Kojita, Hidetoshi Matsuo, Munenobu Nogami, Kazuki Ishikawa, Ryosuke Hatano, Yuka Shimo, Yuki Komon, Yuya Ueki, Izumi Imaoka, Kazuyuki Ohmura, Kazuya Matsuo, Toshiaki Akashi, Shigeki Aoki, Akiko Kusaka, Takamichi Murakami, Yoshihiro Muragaki

  BACKGROUND: Intracranial hemorrhage is life-threatening and requires prompt and accurate diagnosis. Non-contrast head computed tomography is the standard first-line examination, but detecting small hemorrhages and classifying multiple subtypes require substantial expertise. Workforce shortages and increasing diagnostic workloads, especially in emergency settings, further challenge timely decision-making. Artificial intelligence (AI)-assisted interpretation has shown promise for improving accuracy and efficiency. This retrospective study evaluated the effect of AI assistance on the diagnostic performance of radiologic technologists (RTs). METHODS: We analyzed the data for 100 non-contrast head computed tomography examinations (50 positive and 50 negative for hemorrhage) obtained from the Japan Medical Image Database. The interpretations of the five RTs (5-12 years of experience) with and without AI assistance were compared with those of two radiologists. The detection targets were intraparenchymal, intraventricular, subarachnoid, subdural, epidural, and any hemorrhages. We calculated the Area Under the Receiver Operating Characteristic Curve (AUC), accuracy, sensitivity, and specificity. The differences in the AUC for the AI-assisted and unassisted readings were tested using the DeLong method with Bonferroni correction. RESULTS: Significant AUC improvements were observed for five of the 30 reader-task comparisons (17%) after Bonferroni correction. These improvements were all related to intraventricular (p = 0.0001 to 0.0071) and subdural (p = 0.0022 to 0.0071) hemorrhages. CONCLUSION: AI assistance significantly improved RT detection of challenging subtypes such as intraventricular and subdural hemorrhages. However, it did not improve the diagnostic accuracy for detecting any hemorrhage overall (p = 0.0689 to 0.9669). AI can strengthen the role of RTs within task-sharing models and help stabilize preliminary assessments, especially in emergency care and resource-constrained environments.

  2026年, PeerJ, 14, e21414, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Diffuse midline glioma, H3K27-altered, mimicking central neurocytoma on MRI: A case report.

  Yasuyuki Kojita, Tomonori Kanda, Shiho Yokoo, Kazuki Yasuda, Tokinosuke Miyazaki, Feiya Zeng, Naoe Jimbo, Takashi Sasayama, Takamichi Murakami

  Diffuse midline glioma (DMG), H3K27-altered, is an aggressive central nervous system tumor that usually arises in midline structures such as the pons, thalamus, or spinal cord. We present a rare case of intraventricular DMG, H3K27-altered in a 35-year-old woman. MRI showed a soap-bubble appearance, initially suggestive of central neurocytoma, but histopathological and immunohistochemical analyses confirmed the final diagnosis of DMG, H3K27-altered. This is the first reported intraventricular DMG, H3K27-altered with a soap-bubble appearance, underscoring the importance of including this tumor in the differential diagnosis of intraventricular masses.

  2026年01月, Radiology case reports, 21(1) (1), 333 - 338, 英語, 国際誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Clinical and Imaging Features of Syphilis from Head to Toe.

  Shintaro Kano, Akitoshi Inoue, Sota Masuoka, Yashant Aswani, Ayman H Gaballah, Moto Nakaya, Naohiro Sudo, Yasuyuki Kojita, Tomonori Kanda, Kumiko Ando, Taisuke Harada, Mitsuru Matsuki, Osamu Abe, Manabu Minami

  Syphilis, a bacterial infection caused by Treponema pallidum, is resurging globally. It is classified as acquired or congenital syphilis. Acquired syphilis progresses through primary, secondary, and tertiary stages. Pathologically, acquired syphilis is characterized by vasculopathy, perivascular infiltrates in syphilitic lesions, and reactive lymphadenopathy. Primary and secondary syphilis frequently manifest with cutaneous and mucosal lesions accompanied by extensive lymphadenopathy at the initial sites of sexual contact, such as the genitalia, oropharynx, and anorectum. These manifestations may mimic malignancies. Tertiary syphilis encompasses cardiovascular syphilis, late neurosyphilis, and gummas, each manifesting distinct imaging characteristics. Most acquired cases are suspected on the basis of dermatologic signs and patient history and are confirmed serologically. Imaging findings alone may not be diagnostic and can overlap with those of other infectious, inflammatory, or neoplastic conditions, necessitating clinical correlation and laboratory testing. However, in patients with atypical clinical presentations, imaging has an important role in providing valuable diagnostic clues and guiding appropriate clinical treatment. The incidence of congenital syphilis is also increasing in parallel with the overall increase in syphilis infections. A comprehensive understanding of the diverse imaging manifestations in multiple organ systems is vital for radiologists to accurately diagnose and guide appropriate management in the era of resurgent syphilis. The authors provide an overview of acquired and congenital syphilis, detailing the epidemiologic and pathophysiologic characteristics, diagnostic approaches, clinical courses, and imaging features. ©RSNA, 2025 Supplemental material is available for this article.

  2025年06月, Radiographics : a review publication of the Radiological Society of North America, Inc, 45(6) (6), e240170, 英語, 国際誌

  研究論文（学術雑誌）


• Evaluation of amyloid PET positivity using machine learning on 18F-FDG PET images.

  Takahiro Yamada, Yuichi Kimura, Shogo Watanabe, Aya Watanabe, Misa Honda, Takashi Nagaoka, Mitsutaka Nemoto, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Minoru Yamada, SungWoon Im, Atsushi Kono, Kazunari Ishii

  BACKGROUND: Since the approval of disease-modifying drugs for Alzheimer's disease, the demand for amyloid positron emission tomography (PET) scans, which are crucial for determining treatment eligibility, is expected to increase significantly. We thus investigated the ability of an algorithm to predict amyloid accumulation from 18F-fluorodeoxyglucose (FDG)-PET images for use in amyloid PET screening. METHODS: We analyzed the images of 194 subjects with cognitive disorders who had undergone brain FDG-PET, amyloid PET using Pittsburgh compound-B (11C-PiB), and MRI scans at Kindai University Hospital between 2011 and 2018. Among them, 108 subjects showed positive amyloid accumulation; the other 86 did not. For the 108 positive cases, the input values were the region of interest-based calculated from the automatic anatomical labeling template, which divides the brain into 120 regions, and applied to the anatomically standardized FDG-PET images of each subject. We then used a support vector machine (SVM) machine learning algorithm and conducted a tenfold cross-validation to assess the algorithm's accuracy for predicting amyloid accumulation from FDG-PET images. RESULTS: We observed 81.5% accuracy, 78.5% sensitivity, 84.6% specificity, and an area under the curve (AUC) of 0.846 during training. The validation results for the trained model revealed 85.9% accuracy, 88.4% sensitivity, 81.0% specificity, and an AUC of 0.918. CONCLUSION: These results indicate that the performance of our algorithm to predict amyloid accumulation from 18FDG-PET images is adequate for use in amyloid PET scan screenings.

  2025年05月, Japanese journal of radiology, 英語, 国内誌

  研究論文（学術雑誌）


• Extensive brainstem lesions in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A case report.

  Yasuyuki Kojita, Nonoka Okada, Mayumi Hirakawa, Kanako Fujii, Takao Satou, Kazunari Ishii

  Myelin oligodendrocyte glycoprotein antibody-associated disease is a group of central nervous system demyelinating disorders caused by autoantibodies. While myelin oligodendrocyte glycoprotein antibody-associated disease typically presents as optic neuritis and myelitis in adults, this case report details a patient with brainstem lesions. A 45-year-old male presented with episodes of vertigo, nystagmus, and diplopia in left lateral gaze, which had persisted for 2 months, accompanied by headache. Computed tomography showed hyperdensity extending from the left side of the pons to the middle cerebellar peduncle. Magnetic resonance imaging revealed lesions exhibiting heterogeneous diffusion restriction, with enhancement that included granular and linear patterns. 18F-fluorodeoxyglucose positron emission tomography demonstrated increased uptake in these lesions. Following further evaluation, myelin oligodendrocyte glycoprotein antibody-associated disease was diagnosed. Treatment with high-dose corticosteroids initially alleviated symptoms, but symptoms flared upon reduction of the steroids. This case underscores the importance of considering myelin oligodendrocyte glycoprotein antibody-associated disease in the differential diagnosis of brainstem lesions and discusses distinguishing imaging features from similar conditions.

  2024年12月, Radiology case reports, 19(12) (12), 5589 - 5594, 英語, 国際誌

  研究論文（学術雑誌）


• Regional differences in glucose metabolic decline and tau deposition in the Alzheimer's continuum brain.

  Kazunari Ishii, Takahiro Yamada, Kohei Hanaoka, Hayato Kaida, Yasuyuki Kojita, Atsushi Kono, Kazushi Hanada, Kazumasa Saigoh, Shizuka Sakuta, Mamoru Hashimoto, Takashi Kato, Akinori Nakamura

  BACKGROUND: Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, leading to neurofibrillary tangles. A biomarker-based diagnostic method called the ATN system categorizes AD pathology into amyloid-β (A), tau (T), and neurodegeneration (N). The relationship between regional tau deposition and reduced glucose metabolism in the preclinical AD stage is not well understood. OBJECTIVE: We presented voxel-by-voxel metabolic/tau deposition ratio (MTR) images to investigate the effects of tau deposition on metabolism in AD brains on a stage-by-stage basis. METHODS: We selected 174 subjects who underwent 3D-MRI, FDG-PET, amyloid PET, and tau PET scans. MTR images were created by normalizing FDG-PET toMK6240 PET images. Voxel-wise comparisons among 63 cognitively normal amyloid-negative (CNA) subjects, 49 subjects with AD dementia (ADD), 23 subjects with mild cognitive impairment due to AD (MCA), and 39 preclinical AD (PRC) subjects were conducted. RESULTS: There was reduced glucose metabolism in ADD and MCA groups compared to CNA, predominantly in parietotemporal areas. Tau deposition was observed in wider areas in ADD and restricted to the medial temporal lobes in MCA. MTR exhibited significant reductions in broader regions in ADD and MCA, indicating simultaneous glucose metabolism decrease and tau deposition. At the MCA and PRC stages, glucose metabolism impairment and tau deposition were shown in separate regions by FDG PET and tau PET, respectively, while MTR images showed impairment in both regions. CONCLUSIONS: Our findings suggest that MTR imaging provides insights into AD pathophysiology by simultaneously assessing glucose metabolism and tau deposition. In the early stage of the AD continuum (MCA and PRC), metabolic decline and tau deposition occur independently in different brain regions.

  2024年11月, Journal of Alzheimer's disease : JAD, 102(1) (1), 228 - 236, 英語, 国際誌

  研究論文（学術雑誌）


• Neuromyelitis optica spectrum disorder mimicking cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with symmetrical lesions in the temporal poles and external capsules on MRI.

  Yasuyuki Kojita, Atsushi K Kono, Takahiro Yamada, Minoru Yamada, Sung-Woon Im, Takenori Kozuka, Hayato Kaida, Motoi Kuwahara, Yoshitaka Nagai, Kazunari Ishii

  Symmetrical lesions in the temporal poles and external capsules on brain MRI are known as radiological markers of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL); however, similar imaging findings have also been reported in neuromyelitis optica spectrum disorder (NMOSD), and this study investigated the frequency of such findings. The study included 55 NMOSD patients who met the 2015 international NMO diagnosis panel (IPND) criteria and were positive for aquaporin-4 antibodies (AQP4-Ab). Images were evaluated based on the consensus of two neuroradiologists, and brain lesions were detected in 33 patients, of whom 2 (6%) had symmetrical lesions in both the temporal poles and external capsules, and 1 (3%) had symmetrical lesions confined to the external capsules. Therefore, when symmetrical lesions in the temporal poles and external capsules are observed on MRI, NMOSD should be considered in the differential diagnosis.

  2024年08月, Neuroradiology, 英語, 国際誌

  研究論文（学術雑誌）


• Predicting the O'Kelly-Marotta scale score after flow-diverter stent placement using silent MRA.

  Aki Miyazaki, Mizuho Nishio, Atsushi Fujita, Masaaki Kohta, Yasuyuki Kojita, Shintaro Horii, Takashi Sasayama, Takamichi Murakami

  PURPOSE: Flow-diverter (FD) stents were developed to treat aneurysms that are difficult to treat with conventional coiling or surgery. This study aimed to compare usefulness of Silent MRA and TOF (time of flight) -MRA in patients with aneurysms after FD placement. MATERIALS AND METHODS: We retrospectively collected images from 22 patients with 23 internal carotid artery aneurysms treated with FD. Two radiologists conducted MRA and DSA experiments. In the first reading experiment, the radiologists evaluated the aneurysm filling by employing Silent MRA and TOF-MRA and utilizing the modified O'Kelly-Marotta (OKM) scale, a four-class classification system for aneurysms after FD placement. We then calculated the agreement between the modified OKM scale on MRA and the original OKM scale on DSA. In the second reading experiment, the radiologists rated blood flow within the FD using a five-point scale. RESULTS: The weighted kappa value of the OKM scale between DSA and TOF-MRA was 0.436 (moderate agreement), and that between DSA and Silent MRA was 0.943 (almost perfect agreement). The accuracies for the four-class classification were 0.435 and 0.870 for TOF-MRA and Silent MRA, respectively. The mean score of blood flow within FD for TOF-MRA was 2.43 ± 0.90 and that for Silent MRA was 3.04 ± 1.02 (P < 0.001). CONCLUSION: Silent MRA showed a higher degree of agreement than TOF-MRA in aneurysm filling with DSA. In addition, Silent MRA was significantly superior to TOF-MRA in depicting blood flow within the FD. Therefore, Silent MRA is clinically useful for the follow-up of patients after FD placement.

  2024年08月, Japanese journal of radiology, 英語, 国内誌

  研究論文（学術雑誌）

  神戸大学リポジトリ（Kernel）へのリンク


• Differentiating multiple sclerosis and neuromyelitis optica spectrum disorders through pontine trigeminal nerve lesions: A comparative MRI study.

  Yasuyuki Kojita, Atsushi K Kono, Takahiro Yamada, Minoru Yamada, Sung-Woon Im, Takenori Kozuka, Hayato Kaida, Motoi Kuwahara, Yoshitaka Nagai, Kazunari Ishii

  PURPOSE: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are two major demyelinating diseases affecting the central nervous system (CNS). The objective of this study is to evaluate the prevalence of pontine trigeminal nerve lesions in patients diagnosed with MS and NMOSD using MRI. METHODS: This retrospective study included patients diagnosed with MS or NMOSD between July 2018 and July 2023. MS patients were clinically diagnosed using the 2017 McDonald criteria, while NMOSD patients were those who met the 2015 International Panel for NMO Diagnosis (IPND) criteria and were positive for Aquaporin-4 Antibody (AQP4-Ab). RESULTS: The study included a total of 90 patients, with 45 diagnosed with MS and another 45 with NMOSD. Pontine trigeminal nerve lesions were observed in both MS and NMOSD, but were more prevalent in MS patients (20 % vs. 2 %, p = 0.008). Root entry zone (REZ) lesions were found in 4 of 45 MS patients, accounting for 9 % (95 % CI: 3 %-17 %), and were absent in the NMOSD group; however, there was no significant difference between the two groups (p = 0.12). Of the MS patients with pontine trigeminal nerve lesions, 6 out of 9 (63 %; 95 % CI, 36 %-98 %) exhibited bilateral lesions, which was significantly more prevalent compared to the NMOSD group (13 % vs. 0 %, p = 0.03). CONCLUSIONS: The presence of pontine trigeminal nerve lesions, particularly when bilateral, are significantly more prevalent in MS patients than in those with NMOSD, suggesting their utility as a distinctive marker and potential diagnostic indicator specifically for MS.

  2024年07月, European journal of radiology, 178, 111597 - 111597, 英語, 国際誌

  研究論文（学術雑誌）


• Solitary Fibrous Tumor With an Acute Subdural Hematoma: A Case Report and Review of the Literature.

  Tomoya Ohsaka, Yasuyuki Kojita, Atsushi Urase, Ayumi Hirayama, Minoru Yamada, Sung-Woon Im, Atsushi K Kono, Yasuhiro Sanada, Takaaki Chikugo, Noboru Tanigawa, Kazunari Ishii

  Solitary fibrous tumor (SFT) is a rare interstitial tumor that originates from various soft tissues, and SFTs occurring within the cranium are extremely rare. While intracranial SFTs with cerebral hemorrhage or subarachnoid hemorrhage have been reported, there have been no reports of intracranial SFTs causing subdural hematoma. In this case, we report on an intracranial SFT accompanied by a subdural hematoma. A 29-year-old female was emergently transported due to the sudden onset of persistent headache and vomiting that began the night before. CT and MRI imaging revealed a hemorrhagic tumor under the tentorium and an acute subdural hematoma extending along the tentorium. The excised tumor was diagnosed as an SFT through histopathological examination. After undergoing radiation therapy, no recurrence has been observed. This is the first case report of an SFT accompanied by a subdural hematoma, and it is vital to recognize that SFTs can be associated with subdural hematomas for proper diagnosis and treatment planning.

  2024年04月, Cureus, 16(4) (4), e58271, 英語, 国際誌


• 頭部・乳房専用PETが有用であった中枢神経系原発悪性リンパ腫の一例

  甲斐田勇人, 甲斐田勇人, 花岡宏平, 山田穣, 山田穣, 任誠雲, 山田誉大, 小路田泰之, 吉岡宏真, 奥田武司, 石井一成, 石井一成

  2024年, 核医学(Web), 61(1) (1)


• Deep learning model for predicting gestational age after the first trimester using fetal MRI.

  Yasuyuki Kojita, Hidetoshi Matsuo, Tomonori Kanda, Mizuho Nishio, Keitaro Sofue, Munenobu Nogami, Atsushi K Kono, Masatoshi Hori, Takamichi Murakami

  OBJECTIVES: To evaluate a deep learning model for predicting gestational age from fetal brain MRI acquired after the first trimester in comparison to biparietal diameter (BPD). MATERIALS AND METHODS: Our Institutional Review Board approved this retrospective study, and a total of 184 T2-weighted MRI acquisitions from 184 fetuses (mean gestational age: 29.4 weeks) who underwent MRI between January 2014 and June 2019 were included. The reference standard gestational age was based on the last menstruation and ultrasonography measurements in the first trimester. The deep learning model was trained with T2-weighted images from 126 training cases and 29 validation cases. The remaining 29 cases were used as test data, with fetal age estimated by both the model and BPD measurement. The relationship between the estimated gestational age and the reference standard was evaluated with Lin's concordance correlation coefficient (ρc) and a Bland-Altman plot. The ρc was assessed with McBride's definition. RESULTS: The ρc of the model prediction was substantial (ρc = 0.964), but the ρc of the BPD prediction was moderate (ρc = 0.920). Both the model and BPD predictions had greater differences from the reference standard at increasing gestational age. However, the upper limit of the model's prediction (2.45 weeks) was significantly shorter than that of BPD (5.62 weeks). CONCLUSIONS: Deep learning can accurately predict gestational age from fetal brain MR acquired after the first trimester. KEY POINTS: • The prediction of gestational age using ultrasound is accurate in the first trimester but becomes inaccurate as gestational age increases. • Deep learning can accurately predict gestational age from fetal brain MRI acquired in the second and third trimester. • Prediction of gestational age by deep learning may have benefits for prenatal care in pregnancies that are underserved during the first trimester.

  2021年06月, European radiology, 31(6) (6), 3775 - 3782, 英語, 国際誌

  研究論文（学術雑誌）


• 遺伝性出血性毛細血管拡張症に脳静脈血栓症を合併した1例

  杉山朋加, 小路田泰之, 神田知紀, 横尾紫穂, 宮崎亜樹, 松尾秀俊, 村上卓道

  2021年, 臨床放射線, 66(9) (9)


• Diagnostic accuracy of deep-learning with anomaly detection for a small amount of imbalanced data: discriminating malignant parotid tumors in MRI.

  Hidetoshi Matsuo, Mizuho Nishio, Tomonori Kanda, Yasuyuki Kojita, Atsushi K Kono, Masatoshi Hori, Masanori Teshima, Naoki Otsuki, Ken-Ichi Nibu, Takamichi Murakami

  We hypothesized that, in discrimination between benign and malignant parotid gland tumors, high diagnostic accuracy could be obtained with a small amount of imbalanced data when anomaly detection (AD) was combined with deep leaning (DL) model and the L2-constrained softmax loss. The purpose of this study was to evaluate whether the proposed method was more accurate than other commonly used DL or AD methods. Magnetic resonance (MR) images of 245 parotid tumors (22.5% malignant) were retrospectively collected. We evaluated the diagnostic accuracy of the proposed method (VGG16-based DL and AD) and that of classification models using conventional DL and AD methods. A radiologist also evaluated the MR images. ROC and precision-recall (PR) analyses were performed, and the area under the curve (AUC) was calculated. In terms of diagnostic performance, the VGG16-based model with the L2-constrained softmax loss and AD (local outlier factor) outperformed conventional DL and AD methods and a radiologist (ROC-AUC = 0.86 and PR-ROC = 0.77). The proposed method could discriminate between benign and malignant parotid tumors in MR images even when only a small amount of data with imbalanced distribution is available.

  2020年11月, Scientific reports, 10(1) (1), 19388 - 19388, 英語, 国際誌

  研究論文（学術雑誌）


• Intracranial myxoid mesenchymal tumor with EWSR1-CREB1 gene fusion: a case report and literature review.

  Masato Komatsu, Akihiko Yoshida, Kazuhiro Tanaka, Kazuya Matsuo, Takashi Sasayama, Yasuyuki Kojita, Tomonori Kanda, Yoshinori Kodama, Tomoo Itoh, Takanori Hirose

  Intracranial myxoid mesenchymal tumors harboring EWSR1 fusions with CREB transcriptional factor gene families were recently described in several case reports and a few case series and this tumor closely resembles the myxoid variant of angiomatoid fibrous histiocytoma. We herein present an intracranial mesenchymal myxoid tumor arising in the third ventricle of a middle-aged woman. The tumor displayed prominent myxoid features consisting of mildly atypical oval to round cells, arranged in reticular and cord-like structures, with starburst-like amianthoid fibers, whereas it lacked pseudoangiomatoid spaces, pseudocapsules and lymphoid cuffing. Immunophenotypically, tumor cells were positive for EMA, desmin, and ALK (focal). EWSR1 and CREB1 rearrangements were identified using FISH assay. The proliferation index was low. It is currently uncertain whether these myxoid tumors represent a variant of angiomatoid fibrous histiocytoma or a novel tumor entity.

  2020年04月, Brain tumor pathology, 37(2) (2), 76 - 80, 英語, 国内誌

  研究論文（学術雑誌）


• 反復する腹痛と嘔吐で発症した左傍十二指腸ヘルニア-症例報告と本邦小児例の文献レビュー-

  合田由香利, 山口善道, 大片祐一, 會田洋輔, 尾藤祐子, 小路田泰之, 桑田陽一郎, 松原康策

  2020年, 日本小児救急医学会雑誌, 19(2) (2)

• ここが知りたい! 画像診断2024年12月号特集｢ビギナーからエキスパートまでの認知症画像診断｣

  櫻井 圭太, 金田 大太, 小路田 泰之, 石井 一成, 池辺 洋平, 工藤 與亮

  学研メディカル秀潤社, 2025年04月25日, 画像診断, 45(6) (6), 598 - 601


• 【ビギナーからエキスパートまでの認知症画像診断】アミロイドPETでどう迫る?

  小路田 泰之, 石井 一成

  (株)Gakken, 2024年11月, 画像診断, 44(14) (14), 1417 - 1426, 日本語


• 眼窩内蜂巣状軟部肉腫の1例

  廣田 功平, 神田 知紀, 小路田 泰之, 村上 卓道

  (公社)日本医学放射線学会, 2024年09月, 日本医学放射線学会秋季臨床大会抄録集, 60回, S491 - S491, 日本語


• 【画像検査を使いこなす-放射線科医からの贈り物】(第III部)各疾患の画像診断 中枢神経 水頭症

  小路田 泰之, 石井 一成

  (公社)日本医師会, 2024年06月, 日本医師会雑誌, 153(特別1) (特別1), S206 - S207, 日本語


• 【画像診断ガイドラインの使い方-トレーニングと症例集-】脳神経領域のポイント アルツハイマー病

  小路田 泰之, 石井 一成

  (株)メジカルビュー社, 2023年12月, 臨床画像, 39(12) (12), 1338 - 1339, 日本語


• 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】Multinodular and vacuolating neuronal tumor(MVNT)

  小路田 泰之

  (株)Gakken, 2023年08月, 画像診断, 43(10) (10), 1005 - 1008, 日本語


• 【WHO脳腫瘍分類 第5版 徹底解説 Case-based review】Cribriform neuroepithelial tumor(CRINET)

  小路田 泰之

  (株)Gakken, 2023年08月, 画像診断, 43(10) (10), 1018 - 1019, 日本語


• 特集 ビギナーのための頭部画像診断 -Q＆Aアプローチ- 2023 検査の基本-適応･撮像法- 造影MRIの適応や副作用について教えてください.

  小路田 泰之, 神田 知紀, 松尾 秀俊

  学研メディカル秀潤社, 2022年12月25日, 画像診断, 43(1) (1), 12 - 13, 日本語


• 特集 画像でみかける偶発的所見のマネジメント2022 ─あなたならどう書く?─ 1 頭部 両側淡蒼球のT1強調像高信号

  小路田 泰之, 神田 知紀, 松尾 秀俊

  学研メディカル秀潤社, 2022年10月31日, 画像診断, 42(11) (11), A12 - A13, 日本語


• 抗Ma2抗体陽性の傍腫瘍性辺縁系脳炎の1例

  横尾 紫穂, 宮崎 亜樹, 神田 知紀, 小路田 泰之, 村上 卓道

  (公社)日本医学放射線学会, 2021年08月, 日本医学放射線学会秋季臨床大会抄録集, 57回, S391 - S391, 日本語


• 【時系列から学ぶ中枢神経疾患の画像診断-MR Retroscopy-】天幕上(大脳) B.大脳白質 大脳白質病変 そのFLAIR高信号は本当に慢性虚血性変化?

  小路田 泰之, 神田 知紀, 松尾 秀俊

  (株)学研メディカル秀潤社, 2020年08月, 画像診断, 40(10) (10), 1056 - 1059, 日本語


• 気管内挿管後に舌壊死を来した1例

  浦瀬 靖代, 神田 知紀, 小路田 泰之, 上野 嘉子, 祖父江 慶太郎, 前田 隆樹, 野上 宗伸, 村上 卓道

  (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語


• 画像診断における造影剤の使い方 MRIにおけるガドリニウム造影剤の使い方

  神田 知紀, 小路田 泰之

  (株)篠原出版新社, 2019年06月, 乳癌の臨床, 34(3) (3), 245 - 249, 日本語


• 卵巣腫瘍と鑑別を要した肝細胞癌の骨盤内播種

  峯凪り, 小路田泰之, 神田知紀, 浦瀬靖代, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 寺井義人, 山田秀人, 原重雄, 村上卓道

  2019年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th

• CT診断一問一答 : 研修医が最初の1か月で知るべき基礎知識

  村上, 卓道, 神田, 知紀

  Gakken, 2023年10月, 日本語, ISBN: 9784055200530

• 多発性硬化症の診断はどう変わったかー2024年改訂McDonald診断基準とCVS・PRLー

  小路田泰之

  MS診療に役立つMRI新指標の実践, 2026年08月

  [招待有り]


• Comparison of SUVR between amyloid-positive and amyloid-negative groups using high-resolution dedicated head PET with 18F-flutemetamol

  Y. Kojita, K. Ishii, T. Yamada, K. Hanaoka, H. Kaida, T. Kanda, A. Kono, T. Murakami

  European Congress of Radiology 2026, 2026年03月

  ポスター発表


• 嚢胞変性を伴った頭蓋内孤立性線維性腫瘍（solitary fibrous tumor; SFT）の１例

  小路田泰之, 横尾紫穂, 神田知紀, 村上卓道

  第55回 日本神経放射線学会, 2026年02月


• 初回画像では病変の指摘が困難であった80代女性の一例

  小路田泰之, 神田知紀

  第25回MR Retroscopy勉強会, 2025年10月


• 脊椎・脊髄の12疾患：画像所見とその鑑別

  第52回 播淡画像診断研究会, 2025年07月

  [招待有り]


• 感染性心内膜炎の画像診断

  小野有美, 橋村宏美, 小路田泰之, 神田知紀, 高橋宏明, 岡田健次, 村上卓道

  第84回日本医学放射線学会総会, 2025年04月


• Kenney-Caffey症候群2型の1例

  小路田泰之, 神田知紀, 村上卓道

  第54回日本神経放射線学会, 2025年02月

  口頭発表（一般）


• 眼窩内蜂巣状軟部肉腫の一例

  廣田功平, 小路田泰之, 神田知紀, 村上卓道

  第37回 頭頸部放射線研究会, 2024年10月


• 脊髄病変を形成したhistiocytic sarcomaの一例

  廣田功平, 曽菲比, 菅野天祐, 井上純子, 小路田泰之, 神田知紀, 野上宗伸, 村上卓道

  第338回 日本医学放射線学会 関西地方会, 2024年10月


• 非典型な画像所見を呈した視神経脊髄炎スペクトラム障害（NMOSD）の1例

  小路田 泰之, 石井 一成

  第53回日本神経放射線学会


• 最近のびまん性神経膠腫の分類

  小路田 泰之

  第22回近畿放射線医学フォーラム, 2023年10月, 日本語

  口頭発表（一般）


• X連鎖性副腎白質ジストロフィのMR画像所見

  小路田泰之, 神田知紀, 村上卓道

  第51回日本神経放射線学会, 2022年02月, 日本語


• 抗Ma抗体陽性の傍腫瘍性辺縁系脳炎の1例

  横尾紫穂, 宮崎亜樹, 神田知紀, 小路田泰之, 村上卓道

  第57回日本医学放射線学会秋季臨床大会, 2021年09月, 日本語


• 耳管軟骨から生じたと考えられる軟骨系腫瘍の1例

  神田知紀, 神澤真紀, 宮崎亜樹, 小路田泰之, 村上卓道

  第57回日本医学放射線学会秋季臨床大会, 2021年09月, 日本語


• 脊髄に発生したdiffuse midline glioma, H3K27M-mutantの3例

  小路田泰之, 神田知紀, 上野嘉子, 西尾瑞穂, 河野淳, 祖父江慶太郎, 野上宗伸, 前田隆樹, 堀雅敏, 村上卓道

  第50回日本神経放射線学会, 2021年02月, 日本語

  ポスター発表


• 中咽頭腫瘍として発症したGiant cell tumor of tendon sheath

  小路田泰之, 神田知紀, 村上卓道

  第56回日本医学放射線学会秋季臨床大会, 2020年09月, 日本語


• 胎児MRIの頭部画像を用いたディープラーニングによる胎児の週数予測

  小路田泰之, 松尾秀俊, 神田知紀, 西尾瑞穂, 河野淳, 祖父江慶太郎, 野上宗伸, 村上卓道

  第49回日本神経放射線学会, 2020年03月, 日本語

  ポスター発表


• 気管内挿管後に舌壊死を来した1例

  浦瀬靖代, 神田知紀, 小路田泰之, 上野嘉子, 祖父江慶太郎, 前田隆樹, 野上宗伸, 村上卓道

  第55回日本医学放射線学会秋期臨床大会, 2019年10月, 日本語