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明石 昌也
大学院医学研究科 医科学専攻
教授

研究者基本情報

■ 学位
  • 博士（医学）, 神戸大学
■ 研究分野
  • ライフサイエンス / 外科系歯学

研究活動情報

■ 論文
  • Junya Kusumoto, Shungo Furudoi, Yumi Muraki, Moeka Warabi, Daisuke Takeda, Masaya Akashi
    INTRODUCTION: Diffuse sclerosing osteomyelitis (DSO) is a rare nonbacterial bone disease associated with recurrent pain and swelling, and its pathogenesis remains unknown. Despite the absence of an established treatment for DSO, bisphosphonates have recently been considered effective in managing this condition. However, the use of zoledronate is off-label, with limited reported cases. Therefore, this study aimed to investigate the effects of zoledronate on pain suppression in DSO. METHODS: This single-arm retrospective study evaluated adult patients diagnosed with mandibular DSO and treated with zoledronate. Patient demographics, pain suppression effect, recurrence, number of zoledronate administration, adverse reactions to zoledronate, and imaging findings were investigated. RESULTS: The study included 18 patients (median age of 59.5 years). Zoledronate effectively suppressed pain in all patients, with a median duration of effect onset of 1 day. Symptom recurrence was observed in 66.7% of patients, with a median time of 29 months from the first zoledronate administration to recurrence. Zoledronate was administered multiple times to 44.7% of patients. The median duration of response was 80 months for patients who experienced relief after a single administration of zoledronate compared to 32 months for those who received multiple administrations (p < 0.001). Adverse reactions, including flu-like symptoms, were observed in 72.2% of the patients, and no medication-related osteonecrosis of the jaw was observed during the follow-up period. CONCLUSIONS: Zoledronate is a relatively safe and effective treatment option for DSO of the mandible. Key Points • Zoledronate effectively suppresses pain in mandibular diffuse sclerosing osteomyelitis. • All condylar lesions recurred after zoledronate administration. • Patients with mandibular canal enlargement required multiple doses of zoledronate. • Adverse reactions to zoledronate administration were minor.
    2025年04月, Clinical rheumatology, 英語, 国際誌
    研究論文（学術雑誌）

  • Junya Kusumoto, Shungo Furudoi, Daisuke Takeda, Megumi Kishimoto, Masaya Akashi
    INTRODUCTION: Diffuse sclerosing osteomyelitis (DSO) is a non-bacterial osteomyelitis that occurs infrequently and is characterized by recurrent severe pain, swelling of the mandible, and trismus. To date, no effective treatment has been established. Bisphosphonates have been suggested as an efficacious treatment for DSO; however, no prospective studies have examined the effect of bisphosphonate treatment in adults with DSO. This study aims to evaluate the effect of zoledronate on pain suppression in patients with DSO. METHODS: This is a single-center, exploratory, single-arm, prospective interventional study. The participants will include eight patients with DSO of the mandible. The primary endpoint is the change in pain levels before and after zoledronate administration. The secondary endpoints are assessing the efficacy of the clinical course, imaging changes, and safety monitoring. Patients will be enrolled if they are deemed eligible following screening tests and will receive only one 4.0 mg intravenous dose of zoledronate within seven days of enrollment. Study participants will be followed up at one, four, 12, 24, and 48 weeks post-dose or at discontinuation after zoledronate administration. CONCLUSION: This study is the first prospective trial to evaluate the effect of administering a single dose of zoledronate on pain suppression in patients with DSO. We believe this study will lead to the conclusion that zoledronate is an effective treatment for DSO.
    2025年03月, Cureus, 17(3) (3), e80739, 英語, 国際誌
    研究論文（学術雑誌）

  • Kaito Uryu, Yasumasa Kakei, Sho Sendo, Ikuko Goto, Kengo Akashi, Keisuke Nishimum, Tatsuya Shirai, Junya Hirota, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Jun Saegusa, Masaya Akashi
    OBJECTIVES: The effects of systemic inflammation on the temporomandibular joint (TMJ) are poorly understood. This study aimed to establish a mouse model to study the effects of systemic inflammation on the TMJ. MATERIALS AND METHODS: SKG mice, a BALB/c strain with spontaneous onset of rheumatoid arthritis-like symptoms due to a spontaneous point mutation (W163C) in the gene encoding the SH2 domain of ZAP-70, were treated with zymosan (β-1,3-glucan). Synovitis, bone erosion, and cartilage damage in the TMJ were evaluated using established scores for animal models of inflammatory arthritis. Myeloperoxidase-positive areas and numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells were compared between naive and zymosan-treated SKG mice. Correlations between TMJ inflammation scores and clinical scores for extremities were also assessed. RESULTS: There were significant differences in TMJ inflammation scores, including synovitis, bone erosion, and cartilage damage, between naive and high-dose zymosan-treated mice. There were significant differences in myeloperoxidase-positive areas and numbers of TRAP-positive cells between naive and zymosan-treated mice. There were significant correlations between TMJ inflammation scores and clinical scores for extremities. CONCLUSIONS: Systemic administration of zymosan efficiently induces TMJ inflammation in SKG mice. Zymosan-treated SKG mice offer a useful tool to investigate the effects of systemic inflammation on the TMJ.
    2024年12月, Oral diseases, 英語, 国際誌
    研究論文（学術雑誌）

  • Eiji Iwata, Go Inokuchi, Masakazu Kawakami, Taiki Matsui, Junya Kusumoto, Akira Tachibana, Masaya Akashi
    In this study, we aimed to identify risk factors that predict the postoperative need for advanced or prolonged airway management in patients with severe odontogenic deep neck infections (DNIs). This retrospective case-control study included patients of both sexes aged ≥ 18 years who had undergone surgical drainage including debridement of necrotic tissues of odontogenic deep neck abscesses and necrotizing soft tissue infection under general anesthesia between April 2016 and September 2023 at a single center. The patients' characteristics, laboratory tests, and computed tomography (CT) findings were analyzed and compared between the difficult postoperative airway group, which required prolonged intubation or tracheostomy, and the short-term intubation group. Statistical significance was set at P < 0.05. Sixty-four patients required surgical drainage including debridement under general anesthesia. Of them, 7 (10.9%) patients were included in the difficult postoperative airway group. In addition to increased inflammatory markers, the presence of arytenoid edema among laryngeal edema and retro- and parapharyngeal space abscesses on preoperative CT images were identified as risk factors. The presence of pharyngeal space abscesses was significantly associated with laryngeal edema, and the intubation period was longer in patients with more elements relevant to these two factors. Thus, the presence of pharyngeal space abscesses and degree of laryngeal edema on preoperative CT images can be used to predict the complexity of postoperative airway management. Our results suggest that tracheostomy is preferable for patients with retropharyngeal space abscesses, and that patients with parapharyngeal space abscesses and laryngeal edema are desirable to undergo prolonged intubation.
    2024年12月, Odontology, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Dd診断力てすと 右下顎臼歯部の腫瘤
    筧 康正, 明石 昌也
    (株)デンタルダイヤモンド社, 2024年12月, DENTAL DIAMOND, 49(16) (16), 19 - 20, 日本語

  • Junya Kusumoto, Yumi Muraki, Akiko Sakakibara, Shungo Furudoi, Masaya Akashi
    BACKGROUND: Osteoradionecrosis of the jaw (ORN) is a late complication of radiation therapy. Radiation-induced fibrosis is the most likely mechanism for developing ORN, and statins are effective against radiation-induced fibrosis. However, no reports have indicated the direct effectiveness of statins in treating ORN. PURPOSE: This study aimed to measure the association between statin exposure and ORN disease resolution. STUDY DESIGN, SETTING, SAMPLE: This retrospective cohort study included patients with ORN diagnosed between January 2008 and December 2020 at the Hospital's Department of Oral and Maxillofacial Surgery. Patients who were immunocompromised or followed up for < 6 months were excluded. PREDICTOR VARIABLE: The predictor variable was statin exposure, which was defined as the use of statins for dyslipidemia. MAIN OUTCOME VARIABLE: The main outcome variable was ORN disease progression status (good prognosis). Patients who showed full recovery and improvement were included in the good prognosis group, and those who showed invariance and deterioration were included in the poor prognosis group. COVARIATES: We analyzed the clinicodemographic including the age of onset, sex, history of smoking, alcohol consumption, history of chemotherapy, tumor site, association with dental treatment, location (maxilla or mandible), the time to ORN onset from radiation therapy, and stage of ORN, and treatment characteristics including hyperbaric oxygen therapy, long-term macrolide administration, and sequestrectomy. ANALYSES: We analyzed the association between statin exposure or covariates and time to ORN improvement using bivariate and multivariate Cox regression. The significance level was set at P = .05. RESULTS: We analyzed 102 patients, and the improvement rate was 32.4%. The favorable prognostic factors were statin exposure (adjusted hazard ratio [HR], 3.71; 95% confidence interval [CI], 1.62 to 8.50; P = .002), onset in the maxilla (HR, 2.15; 95% CI, 1.02 to 4.55; P = .045), and stage 1 of ORN (HR, 2.65; 95% CI, 1.20 to 5.83; P = .016). CONCLUSION AND RELEVANCE: In this study, statin exposure, onset in the maxilla, and stage 1 of Lyons's classification were favorable prognostic factors for ORN. Although this study's findings were insufficient to recommend statin use for ORN, statins may be a novel and effective treatment for ORN.
    2024年12月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 82(12) (12), 1585 - 1595, 英語, 国際誌
    研究論文（学術雑誌）

  • Yumi Muraki, Atsushi Shioyasono, Mika Nishii, Daisuke Takeda, Junya Kusumoto, Masaya Akashi
    PURPOSE: This study was performed to investigate the association of dental dysplasia with childhood cancer. We examined the occurrence of agenesis, microdontia, and enamel changes of permanent teeth in pediatric cancer survivors. METHODS: Seventy-six patients with pediatric cancer and hematologic diseases were referred to our department for the first time from October 2005 to December 2019. Of these, 17 patients who presented for a checkup in our department fulfilled the study criteria and were analyzed. Clinical examinations and panoramic radiographs were performed to investigate dental dysplasia of permanent teeth. A total of 34 developmental abnormalities (18 missing teeth, 16 cases of microdontia) occurred in 5 patients. The patients' medical records were also analyzed to assess the relationships of specific types of dysplasia with the treatment duration and cumulative drug dose administered. RESULTS: All five pediatric cancer survivors had dental dysplasia; all five had tooth agenesis, and four had microdontia. All five patients were < 4 years of age and had undergone high-dose chemotherapy. CONCLUSION: In this study, childhood cancer survivors who received high-dose chemotherapy before age 4 years experienced the dental dysplasia, including tooth agenesis, microdontia. These findings highlight the need for careful dental monitoring and early intervention in pediatric patients undergoing high-dose chemotherapy. CLINICAL TRIAL NUMBER: This research was conducted in accordance with the Declaration of Helsinki and approved by the Medical Ethics Committee of the Medical University of Kobe (protocol code No. B230066, 1 September 2023).
    2024年11月, Oral and maxillofacial surgery, 29(1) (1), 9 - 9, 英語, 国際誌
    研究論文（学術雑誌）

  • Hiroaki Ohori, Eiji Iwata, Chihiro Ichikawa, Manabu Shigeoka, Yoshiaki Tadokoro, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi
    BACKGROUND: The pathological evaluation of cancellous bone at resection margins of mandibular osteoradionecrosis (ORN) has not been well elucidated. Here, we developed a unique classification system for evaluating the degree of bone marrow fibrosis, one of most common pathological features, in patients with mandibular ORN, based on which we investigated its relationship with treatment outcome. METHODS: This study included 15 patients who underwent mandibulectomy and free fibula osteocutaneous flap reconstruction. The extent of mandibulectomy was determined, with safety margins of approximately 10 mm from the apparent osteolytic areas on preoperative computed tomography image. Special staining was performed on thin sections from center of the osteolytic areas (medial area) and bilateral resection margins, and the degree of bone marrow fibrosis was evaluated and investigated its relationship with presence of bone union as a treatment outcome. RESULTS: The degree of bone marrow fibrosis of medial area was significantly higher than those of resection margins. Although most resection margins had collagen fibers which indicate severe fibrosis, all transferred fibula flaps achieved bone union. CONCLUSION: When mandibulectomy is performed with safety margins of approximately 10 mm from the apparent osteolytic areas, all transferred fibula flaps achieved bone union regardless of the degree of bone marrow fibrosis at resection margin. In other words, the association between severe bone marrow fibrosis at resection margins and treatment outcome was not seen. CLINICAL RELEVANCE: Setting safety margins of approximately 10 mm may achieve bone union, but further study is needed.
    2024年11月, Clinical oral investigations, 28(11) (11), 626 - 626, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 楠元 順哉, 片山 めぐみ, 村木 友美, 明石 昌也
    (一社)日本外科感染症学会, 2024年10月, 日本外科感染症学会雑誌, 21(1) (1), 198 - 198, 日本語

  • Eiji Iwata, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi
    PURPOSE: Mandibular wisdom teeth can occasionally cause infections, which can progress to severe deep neck infections (DNIs) including deep neck abscesses or necrotizing soft tissue infections, which are fatal. This study aimed to identify the radiographic characteristics of mandibular wisdom teeth that developed severe DNIs. METHODS: This study included patients who were admitted for the treatment of severe mandibular wisdom tooth infection between July 2012 and June 2024 at a single center. Patient characteristics, clinical data, and radiographic findings were analyzed and compared between the severe DNI group and mild DNI group including patients with cellulitis or superficial abscess. P < 0.05 was considered significant. RESULTS: Nineteen of 42 patients (45.2%) were included in the severe DNI group. The multivariate analysis showed that the highest odds ratio (OR) was for the presence of a radicular cyst (OR=17.7), followed by the presence of a dentigerous cyst (OR =14.5). The most common mandibular wisdom tooth with a dentigerous cyst in patients with severe DNIs was inverted according to Winter's classification and type IIIC in the Pell and Gregory classification. CONCLUSION: Radiographic characteristics associated with severe DNIs included the presence of radicular and dentigerous cysts in the mandibular wisdom teeth. Especially in dentigerous cysts, deeply impacted teeth should be taken attention.
    2024年10月, Cureus, 16(10) (10), e70791, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 下顎びまん性硬化性骨髄炎に対してゾレドロン酸は有効な治療薬となりうるか?
    楠元 順哉, 古土井 春吾, 村木 友美, 武田 大介, 明石 昌也
    (NPO)日本口腔科学会, 2024年09月, 日本口腔科学会雑誌, 73(2) (2), 195 - 195, 日本語

  • ヒト下歯槽神経のバリア制御に関連する分子の解析
    平岡 佑二郎, 松村 恵実, 筧 康正, 武田 大介, 重岡 学, 木本 明, 長谷川 巧実, 明石 昌也
    (NPO)日本口腔科学会, 2024年09月, 日本口腔科学会雑誌, 73(2) (2), 113 - 113, 日本語

  • 歯の喪失は65歳高齢者の早期要介護発生リスクと関係するか?
    筧 康正, 白井 達也, 長谷川 巧実, 明石 昌也
    (NPO)日本口腔科学会, 2024年09月, 日本口腔科学会雑誌, 73(2) (2), 216 - 216, 日本語

  • Eiji Iwata, Takumi Hasegawa, Hiroaki Ohori, Toshiya Oko, Tsutomu Minamikawa, Daisuke Miyai, Masaki Kobayashi, Naoki Takata, Shungo Furudoi, Junichiro Takeuchi, Kosuke Matsumoto, Akira Tachibana, Masaya Akashi
    PURPOSE: Medication-related osteonecrosis of the jaw (MRONJ) occasionally occurs following tooth extractions in cancer patients receiving denosumab (Dmab). However, there are currently no established guidelines for perioperative antibiotic administration during tooth extraction in these patients. The primary objective was to develop guidelines for the dose and frequency of antibiotics during tooth extraction by investigating the correlation between the current status of antibiotic administration and the development of MRONJ. METHODS: This study included 68 cancer patients receiving high-dose Dmab who had tooth extractions between 2012 and 2022 at 10 hospitals. The relationship between the way of perioperative antibiotic administration and the development of MRONJ was analyzed. A P-value < .05 was considered significant. RESULTS: There was considerable variability across hospitals and surgeons regarding the type, dosage, and duration of antibiotic administration. Amoxicillin (AMPC) was the most commonly used antibiotic. Focusing exclusively on teeth extracted under AMPC administration, MRONJ developed in 21 out of 123 teeth (17.0%). No significant relationship was found between the development of MRONJ and the dosage or duration of perioperative AMPC administration. CONCLUSION: Perioperative antibiotic administration alone may not be sufficient to prevent MRONJ. Therefore, a single preoperative dose is likely adequate for effective and appropriate AMPC administration. .
    2024年08月, Cureus, 16(8) (8), e67237, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Nobuhiro Yamakawa, Masaya Okura, Takumi Hasegawa, Mitsunobu Otsuru, Hironori Sakai, Eiji Hirai, Shin Rin, Shin-ichi Yamada, Souichi Yanamoto, Yusuke Yokota, Masahiro Umeda, Hiroshi Kurita, Michihiro Ueda, Masaya Akashi, Tadaaki Kirita
    Springer Science and Business Media LLC, 2024年05月, International Journal of Clinical Oncology, 29(8) (8), 1122 - 1132
    研究論文（学術雑誌）

  • 頸部膿瘍におけるドレナージ術後抜管困難症例の特徴
    岩田 英治, 楠元 順哉, 薄田 友理子, 橘 進彰, 明石 昌也
    (一社)日本有病者歯科医療学会, 2024年05月, 有病者歯科医療, 33(3) (3), 210 - 211, 日本語

  • 重症感染症と歯性感染症を再考する 重症歯性感染症のスクリーニングと起因菌を含めた重症化因子
    楠元 順哉, 明石 昌也
    (一社)日本口腔感染症学会, 2024年05月, 日本口腔感染症学会雑誌, 31(1) (1), 23 - 31, 日本語

  • Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin ichi Yamada, Hirokazu Nakahara
    2024年04月, Surgery (United States), 175(4) (4), 1128 - 1133
    研究論文（学術雑誌）

  • Taihei Yamguchi, Kazuyo Mori, Yuka Kojima, Takumi Hasegawa, Junya Hirota, Masaya Akashi, Sakiko Soutome, Masako Yoshimatsu, Hiroshi Nobuhara, Yasuhiro Matsugu, Shinichiro Kato, Yasuyuki Shibuya, Hiroshi Kurita, Shin-Ichi Yamada, Hirokazu Nakahara
    BACKGROUND: Pancreaticoduodenectomy has been associated with a high mortality rate and significant postoperative morbidity. Recently, perioperative oral care management has been reported to be effective in preventing postoperative pneumonia and surgical site infection. In this study, we examined the effect of perioperative oral care management in reducing complications after pancreaticoduodenectomy, including surgical site infection. METHODS: This retrospective multicenter study included 503 patients who underwent pancreaticoduodenectomy at 8 facilities between January 2014 and December 2016. Among these, 144 received perioperative oral management by dentists and dental hygienists (oral management group), whereas the remaining 359 did not (control group). The oral care management program included oral health instructions, removal of dental calculus, professional mechanical tooth cleaning, removal of tongue coating, denture cleaning, instructions for gargling, and tooth extraction. The participants were matched using propensity scores to reduce background bias. Various factors were examined for correlation with the development of complications. RESULTS: The incidence of organ/space surgical site infection was significantly lower in the oral management group than in the control group (8.0% vs 19.6%, P = .005). Multivariable logistic regression analysis revealed that hypertension and lack of perioperative oral management were independent risk factors for organ/space surgical site infection. Lack of perioperative oral management had an odds ratio of 2.847 (95% confidence interval 1.335-6.071, P = .007). CONCLUSION: Perioperative oral care management reduces the occurrence of surgical site infections after pancreaticoduodenectomy and should be recommended as a strategy to prevent infections in addition to antibiotic use.
    2024年04月, Surgery, 175(4) (4), 1128 - 1133, 英語, 国際誌
    研究論文（学術雑誌）

  • Yasumasa Kakei, Takeshi Ioroi, Keiko Miyakoda, Takahiro Ito, Masahiko Kashin, Tatsuya Shirai, Takumi Hasegawa, Toshiyasu Sakane, Ikuko Yano, Masaya Akashi
    Introduction In our previous work, we investigated the analgesic effects of ibuprofen gargle after mandibular third molar extractions. However, a subsequent detailed review of individual patient data revealed variations in postoperative pain reduction among patients. Consequently, the present study was designed to conduct post-hoc subanalyses that identified factors contributing to variation in the analgesic response to ibuprofen gargle after third molar extractions. Materials and methods This study involved thirty-five Japanese patients from a prior randomized, double-blind, placebo-controlled, crossover study, which focused on the analgesic effects of ibuprofen gargle after mandibular third molar extractions. Participants were categorized as responders (n = 13) and non-responders (n = 22) based on the within-subject difference (ibuprofen-placebo, IP) of visual analog scale (VAS) changes. Baseline characteristics were compared, along with variables, such as age, sex, the reason for extraction, extraction site, Pell Gregory (space and depth) classification, Winter's classification, surgeon's experience, and surgery time. Baseline characteristics predicting responder status were examined using multivariate logistic regression. Results In the univariate analysis, variables such as age, sex, and baseline VAS scores with p-values <0.2 were evaluated using a stepwise approach. This analysis identified age (per -10 years) with an odds ratio of 4.163 (95% confidence interval (CI): 1.170-31.952, p = 0.0233) and sex (female) with an odds ratio of 9.977 (95% CI: 1.336-208.256, p = 0.0213) as significant predictors of responder status. Conclusions In young and female patients, ibuprofen gargle decreased postoperative pain after mandibular third molar extractions.
    2024年04月, Cureus, 16(4) (4), e57516, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Kusumoto, Masaya Akashi, Hiroto Terashi, Shunsuke Sakakibara
    It is unclear whether normal human skin tissue or abnormal scarring are photoreceptive. Therefore, this study investigated photosensitivity in normal skin tissue and hypertrophic scars. The expression of opsins, which are photoreceptor proteins, in normal dermal fibroblasts (NDFs) and hypertrophic scar fibroblasts (HSFs) was examined. After exposure to blue light (BL), changes in the expression levels of αSMA and clock-related genes, specifically PER2 and BMAL1, were examined in both fibroblast types. Opsins were expressed in both fibroblast types, with OPN3 exhibiting the highest expression levels. After peripheral circadian rhythm disruption, BL induced rhythm formation in NDFs. In contrast, although HSFs showed changes in clock-related gene expression levels, no distinct rhythm formation was observed. The expression level of αSMA was significantly higher in HSFs and decreased to the same level as that in NDFs upon BL exposure. When OPN3 knocked-down HSFs were exposed to BL, the reduction in αSMA expression was inhibited. This study showed that BL exposure directly triggers peripheral circadian synchronization in NDFs but not in HSFs. OPN3-mediated BL exposure inhibited HSFs. Although the current results did not elucidate the relationship between peripheral circadian rhythms and hypertrophic scars, they show that BL can be applied for the prevention and treatment of hypertrophic scars and keloids.
    2024年02月, International journal of molecular sciences, 25(4) (4), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Kusumoto, Yuka Hayase, Yuriko Susukida, Takumi Sato, Akiko Sakakibara, Masaya Akashi
    2024年01月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, 36(1) (1), 58 - 63, 英語
    研究論文（学術雑誌）

  • Aki Sasaki, Daisuke Takeda, Hotaka Kawai, Yoshiaki Tadokoro, Aki Murakami, Nanae Yatagai, Satomi Arimoto, Hitoshi Nagatsuka, Masaya Akashi, Takumi Hasegawa
    Cancer cachexia causes skeletal muscle atrophy, impacting the treatment and prognosis of patients with advanced cancer, but no treatment has yet been established to control cancer cachexia. We demonstrated that transcutaneous application of carbon dioxide (CO2) could improve local blood flow and reduce skeletal muscle atrophy in a fracture model. However, the effects of transcutaneous application of CO2 in cancer-bearing conditions are not yet known. In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, the quadriceps were extracted, and muscle atrophy markers (muscle atrophy F-box protein (MAFbx), muscle RING-finger protein 1 (MuRF-1)) and uncoupling protein markers (uncoupling protein 2 (UCP2) and uncoupling protein 3 (UCP3)) were evaluated by real-time polymerase chain reaction and immunohistochemical staining, and CSA by hematoxylin and eosin staining. The CO2-treated group exhibited significant mRNA and protein expression inhibition of the four markers. Furthermore, immunohistochemical staining showed decreased MAFbx, MuRF-1, UCP2, and UCP3 in the CO2-treated group. In fact, the CSA in hematoxylin and eosin staining and the FFM revealed significant suppression of skeletal muscle atrophy in the CO2-treated group. We suggest that transcutaneous application of CO2 to skeletal muscle suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.
    2024年, PloS one, 19(4) (4), e0302194, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Sato, Yasumasa Kakei, Takumi Hasegawa, Masahiko Kashin, Shun Teraoka, Akinobu Yamaguchi, Ryohei Sasaki, Masaya Akashi
    Introduction: Head and neck squamous cell carcinoma (HNSCC) treatment includes surgery, radiotherapy, and immunotherapy with the aim of eradicating cancer cells without affecting normal tissues. HNSCC expresses epidermal growth factor receptor (EGFR) and cetuximab, an IgG1 monoclonal antibody targeting epidermal growth factor receptor, has been approved for the treatment of HNSCC. However, cetuximab has low reactivity and induces serious side effects. Gold nanoparticles (AuNPs) were reported to enhance the local antitumor effects of radiotherapy without damaging normal cells. Methods and Results: This study investigated the in vitro effects of single and combination therapy with AuNPs (1.0 nM), cetuximab (30 nM), and radiotherapy (4 Gy) on a human HNSCC cell line, HSC-3. Combination treatment of AuNPs + cetuximab + radiotherapy markedly reduced HSC-3 numbers and proliferation and enhanced apoptosis compared with single and double combination treatments. Furthermore, the in vivo combination treatment (AuNPs + cetuximab + radiotherapy) of a xenograft model of HSC-3 cells transplanted into nude mice (BALB/cAJcl-nu/nu) reduced the tumor volume compared with the controls. Scanning electron microscopy demonstrated the presence of AuNPs in tumor tissues and toxicity analysis indicated that AuNPs had no toxic effect on normal tissues. Conclusions: This study showed that AuNPs alone do not have a tumor-suppressing effect, but they sensitize tumors to radiotherapy and bind to cetuximab, leading to enhanced antitumor effects.
    MDPI AG, 2023年12月, Cancers, 15(23) (23), 5697 - 5697
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Satomi Arimoto, Izumi Saito, Nanae Yatagai, Aki Murakami, Aki Sasaki, Yoshiaki Tadokoro, Wakiko Tani, Kiyosumi Kagawa, Masaya Akashi
    PURPOSE: In this study, we prospectively investigated the relationship between bone marrow edema (BME) and odontogenic cysts and explored the possibility of using dual-energy computed tomography (DECT) as an auxiliary tool for the diagnosis of odontogenic cysts. METHODS: This cross-sectional study included 73 patients who underwent the DECT scan and surgery for odontogenic cysts or odontogenic tumors. The virtual noncalcium (VNCa) computed tomography (CT) values and CT values were measured at several sites. The predictor variable was diagnosis, and the other variables included age, sex, and sites. The primary outcome was VNCa CT value. Variables were tested using the chi-square test or the Kruskal-Wallis test. The VNCa CT and CT values were tested using the Scheffe test for multiple comparisons. All variables were analyzed as independent variables affecting the VNCa CT values around the lesion in the multiple regression analysis. RESULT: There were 35 men and 38 women. The mean patient age was 50.0 ± 19.5 years (range: 8-86). The VNCa CT values (- 6.2 ± 34.3) around the lesion in patients with RCs were significantly higher than those in patients with dentigerous cysts (- 44.4 ± 28.6) and odontogenic keratocysts (- 67.3 ± 19.5). In multiple regression analysis, the VNCa CT values around the lesion showed a significant positive correlation with histological results (regression coefficient: - 0.605, P < 0.001). CONCLUSION: The presence of BME is associated with radicular cysts, and DECT can be used as an auxiliary tool for radicular cyst diagnosis.
    2023年12月, Oral and maxillofacial surgery, 27(4) (4), 675 - 684, 英語, 国際誌
    研究論文（学術雑誌）

  • Yasumasa Kakei, Tatsuo Kagimura, Yasuji Yamamoto, Tohmi Osaki, Hiroyuki Kajita, Shinsuke Kojima, Hisatomo Kowa, Miyuki Kawabata, Takumi Hasegawa, Masaya Akashi, Yoji Nagai
    INTRODUCTION: The Kobe project, which utilizes prospective data from the national health insurance system, focuses on early detection and preventive strategies through the Frail Kenshin health check-up program. Previous research has underscored the correlation between tooth loss and the decline in physical and cognitive functions. In this study, using Kobe project data, we examined the link between remaining teeth and long-term care needs in individuals aged 64-65 years, with primary and secondary objectives involving various health parameters and quality of life. METHODS: We analyzed baseline data from a prospective study conducted alongside the Frail Check program for generally healthy individuals aged 64-65 years to examine the relationship between the number of remaining teeth and various health indicators. This study focused on citizens aged 64-65 years to identify those at risk of needing long-term care by the age of 65 years. RESULTS: Data from 1,530 participants were obtained, excluding eight individuals for specific reasons. At the end of the follow-up period, 41 (2.7%) individuals required support and 15 (1.0%) needed long-term care alone. The data revealed a significant association between the number of remaining teeth and the need for long-term care or support, as demonstrated by the Cochran-Armitage trend test (p<0.001). Although trends were noted for nutrition and total Cognitive Functional Instrument Self scores, they did not reach statistical significance. Additionally, a decrease in the number of remaining teeth was significantly associated with worse European Quality of Life Five Dimensions (EQ-5D-5L) visual analog scale scores, mobility, and regular activities (p<0.001). CONCLUSION: Tooth loss indicates the potential long-term care needs of older adults. Monitoring oral health is crucial for addressing care requirements.
    2023年12月, Cureus, 15(12) (12), e49851, 英語, 国際誌
    研究論文（学術雑誌）

  • Takeshi Ioroi, Yasumasa Kakei, Takahiro Ito, Tatsuya Shirai, Yutaro Okazaki, Takumi Hasegawa, Masaya Akashi, Ikuko Yano
    OBJECTIVE: This study was designed to evaluate the postoperative efficacy and safety of using an ibuprofen gargle as a pain management strategy for patients who have undergone mandibular third molar extraction. We also ensured that the quality of treatment was not compromised throughout the study. MATERIAL AND METHODS: Patients were randomized in a 1:1 ratio into two groups: the ibuprofen-placebo (IP) group and the placebo-ibuprofen (PI) group. On postoperative Day (POD) 1, the IP group initiated ibuprofen administration, while the PI group started taking placebo. On POD 2, the IP group switched to using placebo, whereas the PI group switched to ibuprofen. From PODs 3-5, both groups were prescribed ibuprofen gargle. The primary endpoint was within-subject visual analog scale (VAS) score before and 5 min after the first use of the ibuprofen or placebo gargle on PODs 1 and 2 (ΔVAS5_ibuprofen  - ΔVAS5_placebo ). The incidence and severity of adverse events were assessed using the Common Terminology Criteria for Adverse Events version 5.0 and a subjective rating scale. RESULTS: This study enrolled 40 patients. The within-subject VAS5 of the IP and PI groups were 1.25 ± 12.0 and -5.26 ± 8.93 mm, respectively. The treatment effect of ibuprofen gargle was -2.01 ± 10.62 mm (p = .246). None of the patients in each group presented with serious adverse events or clinically significant complications (including dry sockets) after extraction. Transient adverse events, such as throat tingling and oral discomfort (grade 1), were observed in each group. CONCLUSION: Ibuprofen gargle was safe but did not provide significant pain relief when used after mandibular third molar extraction.
    2023年11月, Clinical and experimental dental research, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Satomi Arimoro, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi
    OBJECTIVES: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive and/or antiangiogenic agents. As the treatment application for MRONJ is controversial, we aimed to identify the risk factors for poor prognosis and to help determine appropriate management. METHODS: This study included 119 patients. Relevant clinical data were obtained for all the patients. In computed tomography images, osteosclerosis, osteolysis, cortical perforation (buccal or lingual), periosteal reaction, and sequestration were evaluated. RESULTS: Multivariate analyses showed statistically significant associations between poor prognosis in patients with MRONJ and conservative treatment alone (hazard ratio [HR] 1.89), osteolysis (HR 4.67), and the absence of sequestration (HR 5.33). CONCLUSIONS: Conservative treatment alone without clear objectives needs to be avoided, and osteolytic change could be the criteria for surgical intervention. As the boundary between the lesion and vital bone is indistinct, we recommend extensive surgery in cases with unpredictable sequestration.
    2023年11月, Head & neck, 英語, 国際誌
    研究論文（学術雑誌）

  • Yoshiaki Tadokoro, Daisuke Takeda, Izumi Saito, Nanae Yatagai, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa
    BACKGROUND: Head and neck cancers that cause severe aesthetic and functional disorders normally metastasize to the cervical lymph nodes. Patients with cervical lymph node metastasis are undergoing neck dissection. Shoulder complaints are common after neck dissection, with patients reporting symptoms such as pain, weakness, shoulder droop, and disability. However, no safe and effective treatment is available for this condition at present. We will conduct a double-blinded, randomized controlled trial to evaluate the efficacy of carbon dioxide (CO2) paste in relieving pain in patients after neck dissection. OBJECTIVE: This will be the first clinical study to compare the efficacy of CO2 paste with placebo in relieving postoperative pain in patients who underwent neck dissection. METHODS: We will perform this trial at the Kobe University Hospital in Japan. Patients will be randomized 1:1 into the CO2 paste and control groups. Patients in the CO2 paste group will have the CO2 paste applied to the cervical surface skin for 10 minutes once per day for 14 consecutive days. The primary end point of the study is a change in the visual analog scale (VAS) scores of neck pain from baseline on day 1 (preapplication) to the end of drug application (day 15). Secondary end points include changes in the following parameters from baseline on day 1 to the end of drug application (day 15) or the study (day 29): neck pain VAS score (days 1-29), grip strength (days 1-15 and 1-29), VAS scores for subjective symptoms (the feeling of strangulation, numbness, swelling, and warmth in the neck and shoulder region) for days 1-15 and 1-29, whether the VAS score improved more than 30% (days 1-15), the arm abduction test (days 1-15 and 1-29), shoulder range of motion (abduction and flexion) for days 1-15 and 1-29, occurrence of skin disorders, and occurrence of serious side effects. Periodic monitoring will be conducted for participants during the trial. This study was approved by the certified review board of Kobe University. RESULTS: The intervention commenced in May 2021 and will continue until March 2024. The collected data will provide information on the efficacy of the CO2 paste treatment. The primary end point will be compared using the Wilcoxon test, with the 1-sided significance level set at 5%. Each evaluation item will be summarized. Secondary efficacy end points will be analyzed to provide additional insights into the primary analysis. Findings based on the treatment effects are expected to be submitted for publication in 2025. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of CO2 paste in relieving pain in patients after neck dissection. TRIAL REGISTRATION: Japan Registry of Clinical Trials (jRCT) identifier: jRCTs051210028; https://jrct.niph.go.jp/en-latest-detail/jRCTs051210028. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/50500.
    2023年11月, JMIR research protocols, 12, e50500, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 楠元 順哉, 明石 昌也
    (公社)日本口腔外科学会, 2023年11月, 日本口腔外科学会雑誌, 69(11) (11), 499 - 508, 日本語

  • Kazuki Shigenaga, Satomi Arimoto, Masahiro Kubo, Takumi Sato, Yujiro Hiraoka, Daisuke Takeda, Takumi Hasegawa, Kiyosumi Kagawa, Masaya Akashi
    INTRODUCTION: The present study developed an application using dual-energy computed tomography (DECT) focused on Cu for detecting medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: First, we performed two types of phantom studies using a Cu wire syringe and pig mandible with Cu wire to detect Cu on DECT. Second, DECT examinations of 44 patients with MRONJ were performed to compare lesion and normal bone sites using single-energy CT, DECT-virtual non-calcium (VNCa), and DECT-Cu applications. Quantitative analyses of VNCa CT and CT values were performed, and a cut-off value was calculated using receiver operating characteristic analysis. Third, we compared the Cu content in the MRONJ and normal bone groups using inductively coupled plasma atomic emission spectroscopy (ICP-AES). RESULTS: The material-specific differences in attenuation between the two different energies enabled the accurate separation of Cu from Ca in phantom studies. The sensitivity and specificity for single-energy CT, DECT-VNCa, and DECT-Cu applications were 97.7% and 2.3%, 86.4% and 81.8%, and 88.6% and 97.7%, respectively. Thus, VNCa CT values obtained on DECT-Cu application images showed the highest area under the curve value and maximal diagnostic efficacy in differentiating lesion sites from normal bone sites. On ICP-AES analyses, the Cu content was significantly higher in the MRONJ group than in the normal bone group. CONCLUSION: DECT-Cu application demonstrated better diagnostic performance in detecting MRONJ compared with single-energy CT or DECT-VNCa.
    2023年11月, Journal of bone and mineral metabolism, 41(6) (6), 865 - 876, 英語, 国内誌
    研究論文（学術雑誌）

  • 当科における口腔癌癌患者の下顎の広範囲顎骨支持型装置に際し口腔前庭拡張術を要した11例
    高木 ひかる, 筧 康正, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也
    (公社)日本顎顔面インプラント学会, 2023年11月, Japanese Journal of Maxillo Facial Implants, 22(3) (3), 242 - 242, 日本語

  • Junya Yamashita, Akira Kimoto, Shun Teraoka, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Manabu Shigeoka, Takumi Hasegawa, Masaya Akashi
    OBJECTIVE: Although benign, ameloblastoma is a locally aggressive lesion in some patients and the development of additional treatments is needed. Verteporfin (VP) is a photosensitizer exhibiting considerable photocytotoxicity in various tumor cells. We aimed to investigate the effects of verteporfin photodynamic therapy (VP PDT) on ameloblastoma. METHODS: Eighteen patients who underwent surgery for ameloblastoma were randomly selected. We performed an immunohistochemical assessment to investigate the expression of low-density lipoprotein receptor (LDLR) and Yes-associated protein (YAP), targets of VP, in human ameloblastoma tissues and cultured human ameloblastoma cell line (HAM1). The effect of VP PDT on cell proliferation and apoptosis in HAM1 was analyzed. RESULTS: The expression of LDLR and YAP were detected in human ameloblastoma tissues and HAM1. LDLR expression was significantly higher in patients who had previously undergone surgery than in patients who were receiving it for the first time. The cytotoxic effect of the combination of low-concentration VP administration and laser irradiation was comparable to high-concentration VP administration with and without laser irradiation. The addition of laser irradiation to VP administration significantly accelerated apoptotic bleb formation compared with VP administration alone. CONCLUSION: VP PDT has the potential to become an additional treatment for large-sized ameloblastoma.
    2023年10月, Oral diseases, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T. Hasegawa, N. Ueda, Si Yamada, S. Kato, E. Iwata, S. Hayashida, Y. Kojima, M. Shinohara, I. Tojo, H. Nakahara, T. Yamaguchi, T. Kirita, H. Kurita, Y. Shibuya, S. Soutome, M. Akashi
    2023年10月, Osteoporosis International, 34(10) (10), 1823 - 1825
    研究論文（学術雑誌）

  • Yusuke Yokota, Takumi Hasegawa, Nobuhiro Yamakawa, Shin Rin, Mitsunobu Otsuru, Shin-ichi Yamada, Eiji Hirai, Yuichi Ashikaga, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masahiro Umeda, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Souichi Yanamoto, Masaya Okura
    Elsevier BV, 2023年10月, Oral Oncology, 145, 106519 - 106519
    研究論文（学術雑誌）

  • Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi
    2023年09月, Journal of bone and mineral metabolism, 41(5) (5), 652 - 653, 英語, 国内誌

  • Takumi Hasegawa, Aya Matsuda, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi
    2023年09月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Aki Murakami, Daisuke Takeda, Junya Hirota, Izumi Saito, Rika Amano-Iga, Nanae Yatagai, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa
    Mitochondrial dysfunction and respiratory function changes have been consistently associated with the initiation and progression of cancer. The purpose of this study was to retrospectively investigate the expression of mitochondrial tumor-suppressor and DNA-repair proteins in patients with oral squamous cell carcinoma (OSCC) and to evaluate the relationship between their expression and prognosis. We enrolled 197 patients with OSCC who underwent surgical resection between August 2013 and October 2018. Clinical, pathological, and epidemiological data were retrospectively collected from hospital records. The expression of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), mitochondrial transcription factor A, mitochondrial tumor suppressor gene 1, silent information regulator 3, and 8-hydroxyguanine DNA glycosylase was investigated using immunochemistry. The 3-year disease-specific survival (DSS) rates of patients showing positive expression of all selected proteins were significantly higher than those of patients showing a lack of expression. Multivariate analysis revealed that the expression of PGC-1α (hazard ratio, 4.684) and vascular invasion (hazard ratio, 5.690) can predict the DSS rate (p < 0.001). Low PGC-1α expression and vascular invasion are potential clinically effective predictors of the prognosis of OSCC.
    2023年08月, Cancers, 15(16) (16), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi
    2023年07月, Scientific reports, 13(1) (1), 11216 - 11216, 英語, 国際誌

  • Akira Kimoto, Junya Yamashita, Hiroaki Ohori, Noriyuki Negi, Toshinori Sekitani, Hiroki Komori, Atsushi Shioyasono, Chizu Tateishi, Takumi Hasegawa, Masaya Akashi
    OBJECTIVE: This study aimed to reveal characteristic condylar movements in patients with jaw deformities. STUDY DESIGN: Thirty patients with jaw deformities before surgery were enrolled and instructed to chew a cookie during 4-dimensional computed tomography (4DCT). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT images was measured and compared among patients with different skeletal classes. Correlations between the condylar protrusion and cephalometric values were also determined. RESULTS: The distances of condylar protrusion during mastication were significantly greater in the skeletal class II group than in the skeletal class III group (P=0.0002). Significant correlations were found between the distances of condylar protrusion during mastication and the sella-nasion-B point angle (r=-0.442, P=0.015), A point-nasion-B point angle (r=0.516, P=0.004), sella-nasion plane to ramus plane angle (r=0.464, P=0.01), sella-nasion plane to occlusal plane angle (r=0.367, P=0.047), and condylion-gonion length (r=-0.366, P=0.048). CONCLUSION: Motion analysis with 4DCT images revealed that condylar movement in patients with retrognathism was larger than in patients with mandibular prognathism. Skeletal structure was therefore correlated with condylar movement during mastication.
    2023年07月, The Journal of craniofacial surgery, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • LRINEC scoreは薬剤関連顎骨壊死の合併症としての壊死性筋膜炎の予測に有用か?
    岩田 英治, 楠元 順哉, 薄田 友理子, 橘 進彰, 明石 昌也
    (一社)日本有病者歯科医療学会, 2023年07月, 有病者歯科医療, 32(4) (4), 191 - 192, 日本語

  • TruMatch Reconstruction Systemを用いて行った遊離腓骨皮弁による下顎再建の特徴
    蓮井 友統, 楠元 順哉, 早瀬 悠夏, 明石 昌也
    (NPO)日本口腔科学会, 2023年07月, 日本口腔科学会雑誌, 72(2) (2), 123 - 123, 日本語

  • OHATスコアは膿胸患者の3ヵ月時死亡リスク評価に有用である 傾向スコアマッチング法を用いた後ろ向き観察研究
    岩田 英治, 橘 進彰, 八谷 奈苗, 松井 太輝, 楠元 順哉, 長谷川 巧実, 明石 昌也
    (NPO)日本口腔科学会, 2023年07月, 日本口腔科学会雑誌, 72(2) (2), 158 - 158, 日本語

  • 経皮的炭酸ガスペーストによるラット筋損傷モデルにおける瘢痕化防止と筋再生促進効果
    廣田 純也, 長谷川 巧実, 伊賀 利香, 八谷 奈苗, 黒澤 泉, 武田 大介, 筧 康正, 木本 明, 明石 昌也
    (NPO)日本口腔科学会, 2023年07月, 日本口腔科学会雑誌, 72(2) (2), 166 - 166, 日本語

  • Masanori Nashi, Hiromitsu Kishimoto, Masaki Kobayashi, Akira Tachibana, Motoo Suematsu, Shigeyoshi Fujiwara, Yoshiyuki Ota, Susumu Hashitani, Takeshi Shibatsuji, Tetsuya Nishida, Kazuma Fujimura, Shungo Furudoi, Yoshiki Ishida, Shoichiro Ishii, Tsuyoshi Fujita, Soichi Iwai, Takashi Shigeta, Takeshi Harada, Daisuke Miyai, Daisuke Takeda, Masaya Akashi, Kazuma Noguchi, Toshihiko Takenobu
    2023年07月, JOURNAL OF DENTAL SCIENCES, 18(3) (3), 英語
    研究論文（学術雑誌）

  • Yujiro Hiraoka, Megumi Matsumura, Yasumasa Kakei, Daisuke Takeda, Manabu Shigeoka, Akira Kimoto, Takumi Hasegawa, Masaya Akashi
    Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.
    2023年06月, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 71(6) (6), 221554231182193 - 221554231182193, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Junya Kusumoto, Yuriko Susukida, Taiki Matsui, Naoki Takata, Takumi Hasegawa, Akira Tachibana, Masaya Akashi
    INTRODUCTION: Necrotizing fasciitis as a complication of medication-related osteonecrosis of the jaw (MRONJ), which we named "ONJ-NF", has been sometimes reported. This study aimed to investigate the usefulness of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score for predicting ONJ-NF. MATERIALS AND METHODS: We included patients with acute MRONJ who required hospitalization at a single institution from April 2013 to June 2022. They were divided into two groups: patients with ONJ-NF and those with severe cellulitis as a complication of MRONJ, which we named "ONJ-SC." LRINEC scores were compared between the groups and the cut-off value of the score was set by creating a receiver operating characteristic curve. RESULTS: Eight patients with ONJ-NF and 22 patients with ONJ-SC were included. The LRINEC score was significantly higher in patients with ONJ-NF (median: 8.0 points, range 6-10 points) than in those with ONJ-SC (median: 2.5 points, range 0-6 points). A LRINEC score of ≥ 6 points had a sensitivity of 100.0%, a specificity of 77.3%, and an area under the curve of 0.97. Among 6 parameters of LRINEC score, only C-reactive protein (CRP) and white blood cell count (WBC) had significant differences between two groups. Most of the patients with ONJ-NF were rescued by antibiotic therapy and surgical drainage including debridement of necrotic tissues, but unfortunately, one patient did not survive. CONCLUSION: Our results suggested that the LRINEC score may be a useful diagnostic tool to predict ONJ-NF but valuating only CRP and WBC may be sufficient particularly in patients with osteoporosis.
    2023年06月, Journal of bone and mineral metabolism, 英語, 国内誌
    研究論文（学術雑誌）

  • 埋伏歯の開窓牽引中に生じた頸部膿瘍の1例
    八谷 奈苗, 橘 進彰, 薄田 友理子, 船原 隆一郎, 岩田 英治, 松井 太輝, 楠元 順哉, 明石 昌也
    (一社)日本口腔感染症学会, 2023年05月, 日本口腔感染症学会雑誌, 30(1) (1), 68 - 69, 日本語

  • 船原 隆一郎, 古川 浩平, 松井 太輝, 長谷川 巧実, 梅田 正博, 明石 昌也
    (公社)日本口腔外科学会, 2023年05月, 日本口腔外科学会雑誌, 69(5) (5), 233 - 240, 日本語

  • 当科で新型コロナウイルス感染症に対してPCR検査を行った患者についての考察
    利川 誠将, 武田 大介, 長谷川 巧実, 明石 昌也
    (一社)日本口腔感染症学会, 2023年05月, 日本口腔感染症学会雑誌, 30(1) (1), 65 - 66, 日本語

  • 頭頸部粘膜悪性黒色腫に対する陽子線治療+adjuvant Nivolumab療法
    瓜生 開人, 出水 祐介, 窪田 光, 美馬 正幸, 福光 延吉, 今村 善宣, 明石 昌也, 副島 俊典
    (一社)日本頭頸部癌学会, 2023年05月, 頭頸部癌, 49(2) (2), 234 - 234, 日本語

  • ダプトマイシンの長期投与が奏功したMRSA感染を伴う放射線性下顎骨骨髄炎の1例
    西川 華子, 古土井 春吾, 伊賀 利香, 黒澤 泉, 筧 康正, 明石 昌也
    (一社)日本口腔感染症学会, 2023年05月, 日本口腔感染症学会雑誌, 30(1) (1), 60 - 60, 日本語

  • Junya Yamashita, Kazunobu Hashikawa, Yasumasa Kakei, Toshinori Sekitani, Masaya Akashi
    Implant-supported removable prostheses (ISrP) improve the quality of life, especially in patients who underwent mandibular reconstruction, but few studies have focused on the effect of ISrP in the fibular mandible on the function of the temporomandibular joint. The purpose of this pilot case series was to determine the usefulness of four-dimensional computed tomography (4DCT) images for the evaluation of differences in condylar movements with and without ISrP. Three patients who underwent ISrP following segmental mandibulectomy and free-flap reconstruction were evaluated. The participants were instructed to masticate a cookie during the 4DCT scan. The distance between the most anterior and posterior positions of the condyles on the sagittal view of the 4DCT images during the chewing of the cookies was measured and compared with and without ISrP. 4DCT revealed changes in the distances of condylar protrusion with and without wearing ISrP, but there were no obvious differences among the three patients. The 4DCT motion analysis was useful for the evaluation of the effect of wearing ISrP on condylar movements during mastication in patients with mandibular reconstruction and may become a useful objective evaluation method for the functional evaluation of ISrP.
    2023年05月, Cureus, 15(5) (5), e39419, 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • 歯科衛生士が口腔衛生管理を行った患者に対するCOVID-19発症状況について
    岡崎 葉菜, 武田 大介, 片山 めぐみ, 西井 美佳, 村木 友美, 長谷川 巧実, 明石 昌也
    (一社)日本口腔ケア学会, 2023年04月, 日本口腔ケア学会雑誌, 17(3) (3), 172 - 172, 日本語

  • COVID-19感染が契機と考えられたスティーブンスジョンソン症候群患者への口腔衛生管理の1例
    片山 めぐみ, 村木 友美, 岡崎 葉菜, 西井 美佳, 武田 大介, 長谷川 巧実, 明石 昌也
    (一社)日本口腔ケア学会, 2023年04月, 日本口腔ケア学会雑誌, 17(3) (3), 229 - 229, 日本語

  • Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi
    2023年04月, INTERNATIONAL WOUND JOURNAL, 20(4) (4), 1151 - 1159, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Hirota, Takumi Hasegawa, Atsuyuki Inui, Daisuke Takeda, Rika Amano-Iga, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Masaya Akashi
    In postoperative patients with head and neck cancer, scar tissue formation may interfere with the healing process, resulting in incomplete functional recovery and a reduced quality of life. Percutaneous application of carbon dioxide (CO2 ) has been reported to improve hypoxia, stimulate angiogenesis, and promote fracture repair and muscle damage. However, gaseous CO2 cannot be applied to the head and neck regions. Previously, we developed a paste that holds non-gaseous CO2 in a carrier and can be administered transdermally. Here, we investigated whether this paste could prevent excessive scarring and promote muscle regeneration using a bupivacaine-induced rat model of muscle injury. Forty-eight Sprague Dawley rats were randomly assigned to either a control group or a CO2 group. Both groups underwent surgery to induce muscle injury, but the control group received no treatment, whereas the CO2 group received the CO2 paste daily after surgery. Then, samples of the experimental sites were taken on days 3, 7, 14, and 21 post-surgery to examine the following: (1) inflammatory (interleukin [IL]-1β, IL-6), and transforming growth factor (TGF)-β and myogenic (MyoD and myogenin) gene expression by polymerase chain reaction, (2) muscle regeneration with haematoxylin and eosin staining, and (3) MyoD and myogenin protein expression using immunohistochemical staining. Rats in the CO2 group showed higher MyoD and myogenin expression and lower IL-1β, IL-6, and TGF-β expression than the control rats. In addition, treated rats showed evidence of accelerated muscle regeneration. Our study demonstrated that the CO2 paste prevents excessive scarring and accelerates muscle regeneration. This action may be exerted through the induction of an artificial Bohr effect, which leads to the upregulation of MyoD and myogenin, and the downregulation of IL-1β, IL-6, and TGF-β. The paste is inexpensive and non-invasive. Thus, it may be the treatment of choice for patients with muscle damage.
    2023年04月, International wound journal, 20(4) (4), 1151 - 1159, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroaki Ohori, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Masaya Akashi
    Osteoradionecrosis (ORN) often results in pathological fractures through progression. We aimed to identify the risk factors for pathological fracture in patients with mandibular ORN. Seventy-four patients with mandibular ORN were included in this retrospective study. We investigated various risk factors for pathological fracture in patients with mandibular ORN, including number of mandibular teeth with a poor prognosis each at initial evaluation before radiation therapy (RT) and when fracture occurred, and the proportion of antibiotic administration period in a follow-up duration after RT. The rate of occurrence of pathological fractures in patients with mandibular ORN was 25.7%. The median of duration between RT completion and fracture occurrence was 74.0 months. We found that pathological fracture was significantly associated with a larger number of mandibular teeth with a poor prognosis at initial evaluation before RT (P = 0.024) and when fracture occurred (P = 0.009). Especially, a larger number of mandibular teeth with P4 periodontitis, in other words severe periodontal status, was related to pathological fracture in both timings. The proportion of antibiotic administration period in a follow-up duration was also significant risk factor (P = 0.002). Multivariate analyses showed statistically significant associations between pathological fracture and a larger number of mandibular teeth with a poor prognosis when fracture occurred (hazard ratio 3.669). The patient with a larger number of mandibular teeth with P4 periodontitis may have a risk of not only occurrence of ORN but resulting in pathological fracture by accumulation of infection. Surgeons should consider extraction of those teeth regardless of before/after RT if necessary for infection control.
    2023年04月, Scientific reports, 13(1) (1), 5367 - 5367, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Yasumasa Kakei, Nobuhiro Yamakawa, Tadaaki Kirita, Masaya Okura, Tomofumi Naruse, Mitsunobu Otsuru, Shin-Ichi Yamada, Hiroshi Kurita, Eiji Hirai, Shin Rin, Michihiro Ueda, Masahiro Umeda, Masaya Akashi
    BACKGROUND: The purpose of this retrospective study was to investigate the prognosis of patients with oral cavity cancer with positive margin (PM) or close margin (CM) divided into pN- and pN+ groups. METHODS: The evaluated endpoints were local control and disease-specific survival (DSS) rates. RESULTS: Higher T classification, lymphovascular space invasion (LVSI), and older age were significant risk factors for DSS in the pN- groups. On the other hand, extranodal extension, multiple lymph node metastases, and LVSI were significant risk factors for DSS in the pN+ groups. Among the CM pN+ patients, no significant differences in the 3-year DSS were observed between the only surgery (51.9%) and adjuvant groups (53.2%). CONCLUSIONS: Higher T classification and LVSI are high-risk features more than PM or CM in the pN- groups for DSS. However, further prospective studies are needed to demonstrate the usefulness of adjuvant treatment in patients with PM or CM.
    2023年03月, Head & neck, 45(6) (6), 1418 - 1429, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yumi Kitahiro, Takeshi Ioroi, Yasumasa Kakei, Junya Yamashita, Akira Kimoto, Takumi Hasegawa, Asami Morioka, Kazuhiro Yamamoto, Masaya Akashi, Ikuko Yano
    Oral lichen planus (OLP) is a type of chronic and refractory stomatitis characterized by abnormal keratinization, which is often painful. There is no consensus regarding treatment options for OLP, particularly in the presence of pain. The current study protocol focuses on the short-term efficacy and long-term safety of an ibuprofen gargle for pain management in patients with OLP. Patients (n = 24) with painful OLP will be enrolled. During a crossover study period, patients in the ibuprofen–placebo (IP) group will receive an ibuprofen gargle (0.6%) on day 1, a placebo gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. Patients in the placebo–ibuprofen (PI) group will receive a placebo gargle on day 1, an ibuprofen gargle on day 2, and an ibuprofen gargle on days 3–5 at least once daily. The primary endpoint of the crossover study period is the change in pain level as measured by a visual analogue scale score from before gargle administration to 5 min after gargle administration on days 1 and 2. The primary endpoint of the long-term extension study is assessment of long-term safety. The results of this study may support existing evidence regarding the effectiveness of ibuprofen rinses in treating OLP.
    MDPI AG, 2023年01月, Methods and Protocols, 6(1) (1), 7 - 7
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiaki Tadokoro, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa
    Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumor microenvironment (TME). As CAFs promote tumor progression and hypoxia in the TME, regulating the conversion of normal fibroblasts (NFs) into CAFs is essential for improving the prognosis of patients with OSCC. We have previously reported the antitumor effects of transcutaneous carbon dioxide (CO2) application in OSCC. However, the effects of reducing hypoxia in the TME remain unclear. In this study, we investigated whether CO2 administration improves the TME by evaluating CAFs marker expression. Human OSCC cells (HSC-3) and normal human dermal fibroblasts (NHDF) were coinjected subcutaneously into the dorsal region of mice. CO2 gas was applied twice a week for 3 weeks. The tumors were harvested six times after transcutaneous CO2 application. The expression of CAFs markers (α-SMA, FAP, PDPN, and TGF-β) were evaluated by using real-time polymerase chain reaction and immunohistochemical staining. The expression of α-SMA, FAP, PDPN, and TGF-β was significantly increased over time after co-injection. In the CO2-treated group, tumor growth was significantly suppressed after treatment initiation. In addition, the mRNA expression of these markers was significantly inhibited. Furthermore, immunohistochemical staining revealed a significant decrease in the protein expression of all CAFs markers in the CO2-treated group. We confirmed that transcutaneous CO2 application suppressed CAFs marker expression and tumor growth in OSCC xenograft mouse model.
    2023年, PloS one, 18(8) (8), e0290357, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Teruaki Nishiuma, Suya Hori, Keiko Sugiura, Masato Taki, Shuntaro Tokunaga, Junya Kusumoto, Takumi Hasegawa, Akira Tachibana, Masaya Akashi
    BACKGROUND: Empyema is a life-threatening infection often caused by oral microbiota. To the best of our knowledge, no reports have investigated the association between the objective assessment of oral health and prognosis in patients with empyema. MATERIALS AND METHODS: A total of 63 patients with empyema who required hospitalization at a single institution were included in this retrospective study. We compared non-survivors and survivors to assess risk factors for death at three months, including the Renal, age, pus, infection, diet (RAPID) score, and Oral Health Assessment Tool (OHAT) score. Furthermore, to minimize the background bias of the OHAT high-score and low-score groups determined based on the cut-off value, we also analyzed the association between the OHAT score and death at 3 months using the propensity score matching method. RESULTS: The 3-month mortality rate was 20.6% (13 patients). Multivariate analysis showed that a RAPID score ≥5 points (odds ratio (OR) 8.74) and an OHAT score ≥7 points (OR 13.91) were significantly associated with death at 3 months. In the propensity score analysis, a significant association was found between a high OHAT score (≥7 points) and death at 3 months (P = 0.019). CONCLUSION: Our results indicated that oral health assessed using the OHAT score may be a potential independent prognostic factor in patients with empyema. Similar to the RAPID score, the OHAT score may become an important indicator for the treatment of empyema.
    2023年, PloS one, 18(3) (3), e0282191, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Kusumoto, Eiji Iwata, Wensu Huang, Naoki Takata, Akira Tachibana, Masaya Akashi
    BACKGROUND: Severe odontogenic infections in the head and neck region, especially necrotizing soft tissue infection (NSTI) and deep neck abscess, are potentially fatal due to their delayed diagnosis and treatment. Clinically, it is often difficult to distinguish NSTI and deep neck abscess in its early stage from cellulitis, and the decision to perform contrast-enhanced computed tomography imaging for detection is often a challenge. This retrospective case-control study aimed to examine the utility of routine blood tests as an adjunctive diagnostic tool for NSTI in the head and neck region and deep neck abscesses. METHODS: Patients with severe odontogenic infections in the head and neck region that required hospitalization were classified into four groups. At admission, hematologic and inflammatory parameters were calculated according to the blood test results. In addition, a decision tree analysis was performed to detect NSTI and deep neck abscesses. RESULTS: There were 271 patients, 45.4% in Group I (cellulitis), 22.5% in Group II (cellulitis with shallow abscess formation), 27.3% in Group III (deep neck abscess), and 4.8% in Group IV (NSTI). All hematologic and inflammatory parameters were higher in Groups III and IV. The Laboratory Risk Indicator for Necrotizing Fasciitis score, with a cut-off value of 6 and C-reactive protein (CRP) + the neutrophil-to-lymphocyte ratio (NLR), with a cut-off of 27, were remarkably useful for the exclusion diagnosis for Group IV. The decision tree analysis showed that the systemic immune-inflammation index (SII) of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 suggests Group III + IV and the classification accuracy was 89.3%. CONCLUSIONS: Hematologic and inflammatory parameters calculated using routine blood tests can be helpful as an adjunctive diagnostic tool in the early diagnosis of potentially fatal odontogenic infections. An SII of ≥ 282 or < 282 but with a CRP + NLR of ≥ 25 can be useful in the decision-making for performing contrast-enhanced computed tomography imaging.
    2022年12月, BMC infectious diseases, 22(1) (1), 931 - 931, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 梶原稜, 梶原稜, 山田慎一, 山田慎一, 長谷川巧実, 吉村仁志, 富原圭, 富原圭, 長谷川温, 菱田純代, 上田順宏, 岡本健二朗, 宮腰昌明, 北川善政, 近津大地, 太田嘉英, 渋谷恭之, 明石昌也, 梅田正博, 桐田忠昭, 野口誠, 栗田浩
    2022年11月, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34(6) (6), 734 - 739

  • 当科における口腔癌患者の広範囲顎骨支持型装置の成功率に関する後ろ向き観察研究
    早瀬 悠夏, 長谷川 巧実, 白井 達也, 平岡 佑二郎, 有本 智美, 武田 大介, 筧 康正, 木本 明, 明石 昌也
    (公社)日本顎顔面インプラント学会, 2022年11月, Japanese Journal of Maxillo Facial Implants, 21(3) (3), 237 - 237, 日本語

  • Kyoko Kurioka, Shin Rin, Mitsunobu Otsuru, Tomohumi Naruse, Takumi Hasegawa, Nobuhiro Yamakawa, Shin-Ichi Yamada, Eiji Hirai, Kozo Yamamoto, Michihiro Ueda, Tadaaki Kirita, Masaya Akashi, Hiroshi Kurita, Yoichi Ohiro, Masaya Okura
    The association between the pretreatment body mass index (BMI) and oral squamous cell carcinoma (SCC) outcomes is controversial. We aimed to examine the association between BMI and cause-specific mortality due to cancer of the oral cavity and patterns of failure that correlate with increased mortality. We enrolled 2,023 East Asian patients in this multicenter cohort study. We used the cumulative incidence competing risks method and the Fine-Gray model to analyze factors associated with cause-specific mortality, local recurrence, regional metastasis, and distant metastasis as first events. The median follow-up period was 62 mo. The 5-year cause-specific mortality for patients with underweight was 25.7%, which was significantly higher than that for patients with normal weight (12.7%, P < 0.0001). The multivariate model revealed that underweight was an independent risk factor for cause-specific mortality and regional metastasis (P < 0.05). Moreover, patients with underweight displayed a 51% and 55% increased risk of cause-specific mortality and regional metastasis, respectively, compared with their normal weight counterparts. Local recurrence was not associated with the BMI categories; however, the incidence of distant metastasis inversely decreased with BMI value. In summary, being underweight at diagnosis should be considered a high-risk mortality factor for oral SCC.
    2022年10月, Nutrition and cancer, 1 - 12, 英語, 国際誌
    研究論文（学術雑誌）

  • Shin-Ichi Yamada, Takumi Hasegawa, Nobuhiko Yoshimura, Yusuke Hakoyama, Tetsuya Nitta, Narihiro Hirahara, Hironori Miyamoto, Hitoshi Yoshimura, Nobuhiro Ueda, Yoshiko Yamamura, Hideki Okuyama, Atsushi Takizawa, Yoshitaka Nakanishi, Eiji Iwata, Daisuke Akita, Ryuichi Itoh, Kiriko Kubo, Seiji Kondo, Hironobu Hata, Yoshito Koyama, Youji Miyamoto, Hirokazu Nakahara, Masaya Akashi, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita
    Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient's background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040-1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333-3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050-2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079-6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574-4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction.
    2022年08月, Medicine, 101(32) (32), e29989, 英語, 国際誌
    研究論文（学術雑誌）

  • Manabu Shigeoka, Daisuke Takeda, Masaya Akashi
    2022年08月, CASE REPORTS IN DENTISTRY, 2022, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yuki Sakamoto, Mitsunobu Otsuru, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Masaya Okura, Nobuhiro Yamakawa, Tadaaki Kirita, Souichi Yanamoto, Masahiro Umeda, Yuka Kojima
    The prognosis of oral cancer that has metastasized to the contralateral cervical lymph nodes is poor, although the appropriate treatment method has not been established because of its rarity. A multicenter retrospective study on the treatment and prognosis of pN2c oral cancer patients was conducted. We investigated the treatment and prognosis of 62 pN2c patients out of 388 pN+ patients with oral squamous cell carcinomas. Statistical analysis was performed on the various factors with overall survival (OS) and disease specific survival (DSS). In multivariate cox regression analysis, advanced T stage was significantly correlated with poor OS (p = 0.011) and DSS (p = 0.023) of patients with pN2c neck. In pN2c patients, OS, DSS, and neck control was not different between those undergoing ipsilateral neck dissection initially and those undergoing bilateral neck dissection. Thus, contralateral elective neck dissection is not recommended. The most important risk factor for prognosis in pN2c oral cancer patients is advanced T stage. No evidence was found to recommend contralateral elective neck dissection in clinically N1/2b patients. Therefore, the indication for contralateral elective neck dissection in N1/2b patients should be carefully determined in consideration of individual conditions.
    2022年07月, International journal of environmental research and public health, 19(15) (15), 英語, 国際誌
    研究論文（学術雑誌）

  • Nanae Yatagai, Takumi Hasegawa, Katsusuke Kyotani, Tomohiro Noda, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi
    INTRODUCTION: Scarring and pain are postoperative complications in patients after head and neck cancer treatment; however, there is no effective treatment. These complications are affected by local blood flow disorders, and it is well known that the transcutaneous application of carbon dioxide (CO2) improves local blood flow. Previously, we have shown that the transcutaneous application of carbon dioxide causes absorption of CO2 and increase the oxygen (O2) pressure in the treated tissue; it is expected that the application of CO2 may reduce scarring and pain caused by cancer treatment. We newly introduced the CO2 paste as a new CO2 application method, which does not need to use CO2 gas directly. In this study, we aimed to apply of CO2 paste to healthy people and to investigate its usefulness, safety and feasibility by analysing the increase in blood flow and frequency of adverse events. METHODS: We applied carbon dioxide paste to skin over the sternocleidomastoid and gastrocnemius muscles of eight healthy volunteers. The changes in blood flow before and after the CO2 paste application using dynamic MRI, and changes in the vital signs were evaluated. RESULTS: In the neck area and middle layer of the lower leg, the signal intensity (SI) significantly increased 60 seconds after application. In the surface layer of the lower leg, the SI was significantly increased 60 and 300 seconds after paste application. Although mild heat was noted after the paste application, no obvious adverse events occurred. CONCLUSION: We demonstrated the increase in SI by dynamic MRI at the site of the carbon dioxide paste application, which indicates the paste application is effective in improving the blood flow.
    2022年07月, Medicine, 101(29) (29), e29511, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Kusumoto, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Masaya Akashi
    Wiley, 2022年07月, Microsurgery, 42(5) (5)
    研究論文（学術雑誌）

  • 当科における下顎骨びまん性硬化性骨髄炎症例に関する臨床的検討
    早瀬 悠夏, 楠元 順哉, 古土井 春吾, 武田 大介, 明石 昌也
    (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 81 - 81, 日本語

  • 放射線性顎骨壊死患者を対象とした予後とリスク因子に関する後ろ向き観察研究
    田所 慶誠, 長谷川 巧実, 佐藤 匠, 平岡 佑二郎, 有本 智美, 武田 大介, 楠元 順哉, 明石 昌也
    (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 137 - 137, 日本語

  • 緩和照射に関する臨床的検討
    松添 雄大, 南川 勉, 瓜生 開人, 棚倉 万紀子, 筧 康正, 長谷川 巧実, 明石 昌也
    (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 91 - 91, 日本語

  • 局所的炭酸ガス投与による口腔扁平上皮癌の腫瘍免疫抑制に対する改善効果
    八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 榊原 晶子, 明石 昌也
    (NPO)日本口腔科学会, 2022年07月, 日本口腔科学会雑誌, 71(2) (2), 110 - 110, 日本語

  • Yasumasa Kakei, Kazunobu Hashikawa, Kaito Uryu, Ryuichiro Funahara, Manabu Shigeoka, Masaya Akashi
    PURPOSE: Although the usefulness of polyglycolic acid (PGA) sheet for wound dressing has been recently reported, its histopathological effect on wound healing is not completely elucidated. This pilot study focused on the neo-epithelium formation and the remaining inflammation. METHODS: Full-thickness defects of 8 mm were created on the back of seven-week-old rats. Four rats were divided into the control (raw surface) group and the PGA group, in which the wounds were covered with a PGA sheet. The wounds were assessed on days seven and 12 after wound creation. The length of neo-epithelium on day seven was measured by referring to Masson's trichrome (MT) and α-smooth muscle actin (α-SMA) staining. The remaining inflammation on days seven and 12 was assessed with ionized calcium-binding adapter molecule 1 (Iba-1) staining. RESULTS: The average values of neo-epithelium length on day seven measured by referring to the borderline between MT staining and α-SMA expression were 959.2 μm in the control group and 582.2 μm in the PGA group. The number of Iba-1-positive cells on day 12 was significantly higher in the PGA group than in the control group. CONCLUSIONS: To assess the neo-epithelium length and the remaining inflammation, the α-SMA, MT, and Iba-1 staining may be appropriate.
    2022年07月, Cureus, 14(7) (7), e27209, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Satomi Arimoto, Takumi Hasegawa, Eiji Iwata, Daisuke Takeda, Masaya Akashi
    Mechanical stress induces a variety of biochemical and morphological reactions in bone cell biology. This study aimed to investigate appropriate pressures of osteogenesis on the biological responses of 3-dimensional cultured human mandibular fracture haematoma-derived cells by compressive loading. Six patients with mandibular fractures who underwent open reduction and internal fixation were included in the study. During the operation, fracture haematomas that formed fibrin clots were manually removed before irrigation. First, pressures were applied to human mandibular fracture haematoma-derived cell-seeded collagen sponges. The sponges were subjected to mechanical compression using loading equipment applied at no compression, 0.5, or 1 mm. Compressive loading was applied to the samples prior to compression for 0, 6, 12, or 24 hours. Collagen sponge samples were collected for quantification of mRNA using several parameters including alkaline phosphatase (ALP), osteopontin (OPN), osterix (OSX), runt-related gene 2 (RUNX2), protein level, and immunocytochemistry (anti-sclerostin). Among these the 0.5 mm compression group compared with the control and 1.0 mm compression groups upregulated mRNA expression of OPN and OSX after 24 hours. Additionally, compared with the control group, a significantly higher OSX gene expression was observed in both the 0.5 mm and 1.0 mm groups after 6, 12, and 24 hours of compression (p < 0.05). However, no significant differences were observed regarding ALP and RUNX2 expression. These results indicated increased stimulation of osteogenesis of the mandibular fracture-line gap in the 0.5 mm compression group compared with the control and 1.0 mm compression groups.
    2022年06月, The British journal of oral & maxillofacial surgery, 60(9) (9), 1216 - 1223, 英語, 国際誌
    研究論文（学術雑誌）

  • 放射線性下顎骨壊死の低体重患者に下顎骨区域切除を行った1例
    早瀬 悠夏, 楠元 順哉, 薄田 友理子, 佐藤 匠, 印南 勇祐, 明石 昌也
    (一社)日本口腔感染症学会, 2022年06月, 日本口腔感染症学会雑誌, 29(1) (1), 34 - 35, 日本語

  • Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi
    2022年06月, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19(11) (11), 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hirokazu Komatsu, Tatsuya Furukawa, Keisuke Iritani, Shun Tatehara, Miki Takahashi, Shinobu Iwaki, Yasumasa Kakei, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Masaya Akashi, Ken-Ichi Nibu
    OBJECTIVE: The blowing time ratio, which is the ratio of the blowing time when the nostrils are open and closed, is significantly correlated with velopharyngeal pressure, not only during speech but also during swallowing. This study aimed to further evaluate the usefulness of the blowing time ratio as a screening tool to evaluate the swallowing pressure of patients treated for oral and oropharyngeal cancers using high-resolution manometery (HRM). METHODS: Ten patients treated for oral or oropharyngeal cancer were recruited for this study. Swallowing pressures at the velopharynx, oropharynx, and upper esophageal sphincter (UES) were measured using HRM. Their correlations with the blowing time ratio were analyzed. RESULTS: The blowing time ratio was significantly correlated with the swallowing pressures of the oropharynx (CC = 0.815, p = 0.004) and the velopharynx (CC = 0.657, p = 0.039), but not of the UES. CONCLUSIONS: The present results further support our previous finding that the blowing time ratio is a useful screening tool to evaluate velopharyngeal and oropharyngeal swallowing pressures in patients treated for oral and oropharyngeal cancer.
    2022年06月, Auris, nasus, larynx, 49(3) (3), 477 - 483, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiaki Tadokoro, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Eiji Iwata, Izumi Saito, Junya Kusumoto, Masaya Akashi
    A standard treatment for osteoradionecrosis (ORN) has not yet been established because of the diversity. Therefore, identifying the risk factors for a poor prognosis is essential. This study retrospectively investigated the factors associated with the prognosis of ORN in 68 patients. Relevant clinical data of all patients were obtained. Of the patients, 16 who underwent extensive surgery underwent histopathological analysis. The necrotic changes of the anterior and posterior margins in the cortical and cancellous bones were investigated. Multivariate analyses showed statistically significant associations between poor prognosis in patients with ORN and high radiation dose (hazard ratio [HR] 1.15), orocutaneous fistula (HR 2.93), and absence of sequestration (HR 2.49). Histopathological analysis showed a viable anterior margin of the middle portion of the cortical bone for all recovered cases; in contrast, most cases (75%) with a poor prognosis showed necrotic changes. The anterior margin of the cancellous bone was viable and resilient to high irradiation, regardless of the prognosis. These results suggest that patients with orocutaneous fistula should receive early surgical intervention, even if the affected area is limited or asymptomatic. In extensive surgery, a sufficient safety margin of necrotic bone, particularly in the anterior region, is required to improve the prognosis.
    2022年05月, International journal of environmental research and public health, 19(11) (11), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yasumasa Kakei, Takeshi Ioroi, Takahiro Ito, Yutaro Okazaki, Takumi Hasegawa, Ikuko Yano, Masaya Akashi
    BACKGROUND: Extraction of mandibular third molars is one of the most commonly performed oral surgical procedures, and nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management. Oral NSAIDs are associated with adverse events such as gastrointestinal disorders, renal and hepatic dysfunction, and platelet dysfunction. Topical analgesics have been proposed as alternatives to oral and injectable medications to safely improve postoperative pain relief. We will conduct a single-center, placebo-controlled, double-blind, randomized crossover trial to assess the pain-relieving effect of an ibuprofen-containing gargle in patients undergoing extraction of mandibular third molars when compared with a placebo gargle. OBJECTIVE: This will be the first clinical study to compare the efficacy of an ibuprofen gargle with that of a placebo for relieving postoperative pain in addition to loxoprofen after mandibular third molar extraction. METHODS: This study will be performed at Kobe University Hospital. Participants (N=40) will be randomized equally to 1 of 2 groups. The ibuprofen-placebo group will receive an ibuprofen gargle on postoperative day (POD) 1 and a placebo gargle on POD 2. The placebo-ibuprofen group will receive a placebo gargle on POD 1 and an ibuprofen gargle on POD 2. Both groups will receive ibuprofen gargles on PODs 3-5 at least once daily. The primary objective is to estimate the within-subject difference on a visual analog scale (VAS) before and 5 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2. The secondary objectives are to estimate the within-subject differences in ΔVAS before and 15 minutes after using the ibuprofen or placebo gargle on PODs 1 and 2, ΔVAS before and 5 or 15 minutes after using the ibuprofen gargle on PODs 3-5, overall efficacy (self-completion, 5 scales) on PODs 1-5, daily frequency of use (ibuprofen or placebo gargle and analgesics) on PODs 1-7, and the occurrence of adverse events. RESULTS: The Certified Review Board of Kobe University approved the study. The intervention was implemented in May 2021. For the primary analysis, we will calculate the mean and SD of ΔVAS5 on PODs 1 and 2 and the within-study difference in ΔVAS5. The treatment effect will be estimated by dividing the mean ΔVAS5 in the within-subject difference by 2 and calculating the P value using an unpaired t test. For the secondary analysis, we will calculate the mean and SD of ΔVAS15 on PODs 1 and 2 and the within-study difference in ΔVAS15. The treatment effect will be estimated as in the primary analysis. CONCLUSIONS: This trial will provide exploratory evidence of the efficacy and safety of an ibuprofen gargle for pain reduction after mandibular third molar extraction. TRIAL REGISTRATION: Japan Registry of Clinical Trials jRCTs051210022; https://tinyurl.com/39ej23zu. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/35533.
    2022年05月, JMIR research protocols, 11(5) (5), e35533, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takayuki Kodama, Manabu Shigeoka, Mari Nishio, Yu-Ichiro Koma, Masaya Akashi, Hiroshi Yokozaki
    2022年05月, Oral diseases, 英語, 国際誌
    研究論文（学術雑誌）

  • Hiroshi Nobuhara, Yasuhiro Matsugu, Sakiko Soutome, Saki Hayashida, Takumi Hasegawa, Masaya Akashi, Shin-Ichi Yamada, Hiroshi Kurita, Hirokazu Nakahara, Miyuka Nakahara, Nobuhiro Ueda, Tadaaki Kirita, Tomohisa Nakamura, Yasuyuki Shibuya, Kazuyo Mori, Taihei Yamaguchi
    BACKGROUND: Surgical site infection is a common postoperative complication of colorectal cancer surgery, and surgical site infection increases medical costs, prolongs hospitalization, and worsens long-term prognosis. Perioperative oral care has been reported to be effective in preventing postoperative pneumonia, although there are only a few reports on its effectiveness in preventing surgical site infection. This study aimed to determine the role of perioperative oral care in surgical site infection prevention after colorectal cancer surgery. METHODS: In this study, 1,926 patients with colorectal cancer from 8 institutions were enrolled; 808 patients (oral care group) received perioperative oral care at the hospital's dental clinic, and 1,118 (control group) did not receive perioperative oral care. The data were matched by propensity score to reduce bias. Ultimately, a total of 1,480 patients were included in the analysis. RESULTS: The incidence of surgical site infection was significantly lower in the oral care group than in the control group (8.4% vs 15.7%, P < .001). Multivariate logistic regression analysis revealed 4 independent risk factors for surgical site infection: low albumin level, rectal cancer, blood loss, and lack of perioperative oral care. Lack of perioperative oral care had an odds ratio of 2.100 (95% confidence interval 1.510-2.930, P < .001). CONCLUSION: These results suggest that perioperative oral care can reduce the incidence of surgical site infection after colorectal cancer resection. Perioperative oral care may have an important role in the future perioperative management of colorectal cancer as a safe and effective method of surgical site infection prevention, although further validation in prospective studies is needed.
    2022年04月, Surgery, 172(2) (2), 530 - 536, 英語, 国際誌
    研究論文（学術雑誌）

  • 口腔粘膜炎に対するエピシル口腔溶液の効果や有効性について
    岡崎 葉菜, 武田 大介, 西井 美佳, 村川 智美, 片山 めぐみ, 澤田 麻衣子, 楠元 順哉, 明石 昌也
    (一社)日本口腔ケア学会, 2022年04月, 日本口腔ケア学会雑誌, 16(3) (3), 140 - 140, 日本語

  • 頭頸部がん放射線療法における口腔カンジダ症に対するミコナゾール貼付薬の有効性について
    西井 美佳, 楠元 順哉, 村川 智美, 岡崎 葉菜, 片山 めぐみ, 澤田 麻衣子, 武田 大介, 明石 昌也
    (一社)日本口腔ケア学会, 2022年04月, 日本口腔ケア学会雑誌, 16(3) (3), 141 - 141, 日本語

  • Junya Kusumoto, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Masaya Akashi
    BACKGROUND: Non-thrombotic skin paddle necrosis occasionally occurs during mandibular reconstructions with free fibula osteocutaneous flaps. The number of perforators, size of the skin paddle, and ischemia time of the flap are considered as causes of skin paddle necrosis. The importance of donor side selection has also been highlighted. This study aimed to investigate the leading cause of skin paddle necrosis and the optimal reconstructive procedure. METHODS: A total of 66 patients who underwent mandibular reconstruction using a free fibula osteocutaneous flap were retrospectively analyzed. Skin paddle necrosis, number of cutaneous perforators, size of the skin paddle, and ischemia time of the flap were investigated. An incorrect "laterality" was defined as a skin paddle (septum) covering the reconstruction plate. Donor-site morbidity was recorded. RESULTS: Skin paddle necrosis occurred in 15.2% of patients. An incorrect laterality was associated with a higher incidence of skin paddle necrosis (odds ratio, 22.0; 95% confidence interval, 2.5-195; p = .005). Donor-site morbidity was noted in 18.8% of the patients, without any significant difference in terms of the donor side with and without skin graft (p = .592). The postoperative activities of daily living were not affected. CONCLUSIONS: To prevent skin paddle necrosis, donor side selection is an important safety strategy during mandibular reconstruction with free fibula osteocutaneous flap. The postoperative activities of daily living were found to be little affected by differences in the donor side.
    2022年03月, Microsurgery, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Aki Sasaki, Izumi Saito, Satomi Arimoto, Nanae Yatagai, Yujiro Hiraoka, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi
    OBJECTIVES: This study aimed to retrospectively investigate the success and survival rates of dental implants used for dentomaxillary prostheses at our hospital and the risk factors associated with large bone defects. MATERIALS AND METHODS: A total of 138 external joint system implants used for dentomaxillary prostheses in 40 patients with large bone defects were included in this study. The alveolar bone at the site of implant insertion was evaluated using panoramic radiography and computed tomography. Various risk factors (demographic characteristics, dental status, and operative factors such as the employment of alveolar bone augmentation, the site, the length, and diameter of implants) for implant failure and complete implant loss were investigated using univariate and multivariate analyses. The associations between the variables and the success and survival rates of dental implants were analyzed using the multivariate Cox proportional hazard models. RESULTS: The 10-year overall success and survival rates were 81.3% and 88.4% in this study. Multivariable analysis showed that the male sex (HR 6.22), shorter implants (≤ 8.5 mm) (HR 5.21), and bone augmentation (HR 2.58) were independent predictors of success rate. Bone augmentation (HR 5.14) and narrow implants (≤ 3.3 mm) (HR 3.86) were independent predictors of the survival rate. CONCLUSION: Male sex, shorter or narrow implants, and bone augmentation were independent risk factors for dental implants used in dentomaxillary prostheses in patients with large bone defects. CLINICAL RELEVANCE: Clinicians should consider these risk factors and pay close attention to the management of these patients.
    2022年03月, Clinical oral investigations, 26(3) (3), 2743 - 2750, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Takumi Hasegawa, Ryo Kadoya, Yui Enomoto, Naoki Takata, Masaya Akashi
    PURPOSE: The purpose of this study was to investigate the risk factors associated with post-extraction persistent bleeding in patients on warfarin or direct-acting oral anticoagulants (DOACs) and the ability of risk scores to predict post-extraction bleeding. METHODS: Three hundred ninety-one patients taking warfarin or DOACs underwent tooth extractions. Various risk factors for post-extraction bleeding, including number of tooth extraction, with antiplatelet therapy, and risk scores, were investigated by univariate and multivariate analyses. A post-extraction bleeding was classified into grades 1-3. RESULTS: The incidence of post-extraction bleeding was 26.8% (77 out of 287 patients; grade 1: 63, grade 2:14) in patients taking warfarin, and 26.0% (27 out of 104 patients; grade 1: 20, grade 2:7) in patients taking warfarin DOACs. Multivariate analyses showed that multiple teeth extractions and HAS-BLED scores (above 3 points) in patients taking warfarin, and only multiple teeth extractions in patients taking DOAC, were significantly associated with post-extraction bleeding, respectively. CONCLUSION: Most of the post-extraction bleedings were grade 1, which can be stopped by eligibly pressing gauze by surgeons. If patients taking anticoagulants are scheduled to undergo multiple teeth extractions or their HAS-BLED score are above 3 points (if warfarin), we recommend informing patients risk of post-extraction bleeding before operation, taking carefully hemostasis, and instructing patients to bite down accurately on the gauze for longer than usual.
    2022年01月, Oral and maxillofacial surgery, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Manabu Shigeoka, Daisuke Takeda, Masaya Akashi
    Actinomycosis is usually a chronic infectious disease caused by Actinomyces species, which are anaerobic Gram-positive bacteria that normally colonize the human oral cavity and digestive and urogenital tracts. Although this lesion often occurs on soft tissue around the mandible, cases localized in the lip are very uncommon. We encountered a patient with actinomycosis in the lower lip. A 76-year-old woman with a 5-mm submucosal nodule of the lower lip was referred to our hospital from a dental clinic. The clinical diagnosis was a benign submucosal tumor. Total excision and histological examination were conducted. No oral antibiotic therapy was prescribed. The histological diagnosis was actinomycosis. The postoperative course was uneventful with no signs of recurrence during the 6 months after surgery.
    2022年, Case reports in dentistry, 2022, 6121315 - 6121315, 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • A Case of a Rare Branching Pattern in the Carotid Artery.
    Ayumi Sakai, Kazunobu Hashikawa, Akiko Sakakibara, Nobuyuki Murai, Tadashi Nomura, Masaya Akashi, Hiroto Terashi
    2022年, Eplasty, 22, ic1, 英語, 国際誌

  • 筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也
    (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, 日本語

  • 筧 康正, 永井 洋士, 長谷川 巧実, 明石 昌也
    (一社)日本口腔腫瘍学会, 2021年12月, 日本口腔腫瘍学会誌, 33(4) (4), 159 - 163, 日本語

  • 口腔癌術後の再建組織より採取した分層植皮により顎堤形成術を施行した1例
    重永 一輝, 有本 智美, 武田 大介, 木本 明, 長谷川 巧実, 明石 昌也
    (公社)日本顎顔面インプラント学会, 2021年11月, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 189 - 189, 日本語

  • 放射線下顎骨壊死に対する腓骨皮弁再建後にインプラントによる咬合回復を行った1例
    武田 大介, 有本 智美, 長谷川 巧実, 明石 昌也
    (公社)日本顎顔面インプラント学会, 2021年11月, Japanese Journal of Maxillo Facial Implants, 20(3) (3), 227 - 227, 日本語

  • Rika Amano-Iga, Takumi Hasegawa, Daisuke Takeda, Aki Murakami, Nanae Yatagai, Izumi Saito, Satomi Arimoto, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi
    INTRODUCTION:  Delayed wound healing after surgery lowers the long-term quality of a patient's life and leads to discomfort and pain. However, treatments for wound healing are often difficult and have not yet been fully established. In this study, we investigated the effect of a special paste that can be administered transdermally and holds a non-gaseous carbon dioxide (CO2) source in its carrier, which can be applied to the head and neck region for wound healing in a rat skin defect model. METHODS: Forty-eight Sprague Dawley rats were randomized into control and CO2 groups. We punched a 6.2-mm wound on the back of each rat. The control rats were left untreated, whereas rats in the CO2 group were treated with the CO2 paste every day after surgery. We evaluated wound healing 3, 7, 14, and 21 days after wounding by analyzing the diameter of the wound, gene expression of inflammatory markers vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β, hypoxia-inducible factor (HIF)-1α, interleukin (IL)-1β, and IL-6 using quantitative real-time polymerase chain reaction, hematoxylin and eosin, and immunohistochemical staining patterns. RESULTS: Rats in the CO2 group showed accelerated wound healing compared to those in the control group. Furthermore, VEGF and TGF-β were overexpressed, whereas HIF-1α, IL-1β, and IL-6 were downregulated in the rats treated with CO2. Immunohistochemical analysis also revealed similar patterns of expression. CONCLUSION: Taken together, the CO2 paste promoted wound healing by regulating the hypoxic environment, reducing inflammation, and accelerating angiogenesis.
    2021年11月, Cureus, 13(11) (11), e19518, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Sakiko Soutome, Souichi Yanamoto, Mika Nishii, Yuka Kojima, Takumi Hasegawa, Madoka Funahara, Masaya Akashi, Toshiyuki Saito, Masahiro Umeda
    2021年10月, Journal of Dental Sciences, 16(4) (4), 1241 - 1246
    研究論文（学術雑誌）

  • Sturge-Weber症候群に伴う口腔内化膿性肉芽腫の治療経験:術前塞栓療法と外科的切除の併用
    酒井 亜結美, 野村 正, 明石 昌也, 橋川 和信, 寺師 浩人
    (一社)日本形成外科学会, 2021年09月, 日本形成外科学会会誌, 41(9) (9), 522 - 527, 日本語

  • Akiko Sakakibara, Takumi Hasegawa, Daisuke Takeda, Junya Kusumoto, Shunsuke Sakakibara, Masaya Akashi
    Schwannomas commonly occur in the head and neck region as acoustic neuromas. Facial nerve schwannomas are rare and usually occur in the temporal region. A 57-year-old woman presented with a mass at the right mandibular margin. Magnetic resonance imaging revealed a schwannoma located immediately caudal to the mental foramen. We were initially uncertain whether it arose from the trigeminal nerve or the facial nerve. Excision was performed under general anesthesia. The mass was encapsulated and easily detached from the surrounding tissue. The nerve of origin was identified proximal to the tumor. A facial nerve origin was confirmed as the muscles supplied by the marginal mandibular branch of the facial nerve moved on nerve stimulation. Nerve fibers were not found distal to the tumor, possibly because they had been cut during excision. We believe that this is the first report of a schwannoma arising from the peripheral facial nerve.
    2021年07月, Journal of surgical case reports, 2021(7) (7), rjab299, 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • 榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也
    (公社)日本口腔外科学会, 2021年07月, 日本口腔外科学会雑誌, 67(7) (7), 447 - 451, 日本語

  • 皮膚充填材への感染により生じた頬部蜂窩織炎の1例
    榎本 由依, 橘 進彰, 格谷 僚, 岩田 英治, 高田 直樹, 明石 昌也
    (公社)日本口腔外科学会, 2021年07月, 日本口腔外科学会雑誌, 67(7) (7), 447 - 451, 日本語

  • Manabu Shigeoka, Yu-ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
    BackgroundCD163-positive macrophages contribute to the aggressiveness of oral squamous cell carcinoma. We showed in a previous report that CD163-positive macrophages infiltrated not only to the cancer nest but also to its surrounding epithelium, depending on the presence of stromal invasion in tongue carcinogenesis. However, the role of intraepithelial macrophages in tongue carcinogenesis remains unclear. In this study, we assessed the biological behavior of intraepithelial macrophages on their interaction with cancer cells. Materials and MethodsWe established the indirect coculture system (intraepithelial neoplasia model) and direct coculture system (invasive cancer model) of human monocytic leukemia cell line THP-1-derived CD163-positive macrophages with SCC25, a tongue squamous cell carcinoma (TSCC) cell line. Conditioned media (CM) harvested from these systems were analyzed using cytokine array and enzyme-linked immunosorbent assay and extracted a specific upregulated cytokine in CM from the direct coculture system (direct CM). The correlation of both this cytokine and its receptor with various clinicopathological factors were evaluated based on immunohistochemistry using clinical samples from 59 patients with TSCC. Moreover, the effect of this cytokine in direct CM on the phenotypic alterations of THP-1 was confirmed by real-time polymerase chain reaction, western blotting, immunofluorescence, and transwell migration assay. ResultsIt was shown that CCL20 was induced in the direct CM specifically. Interestingly, CCL20 was produced primarily in SCC25. The expression level of CCR6, which is a sole receptor of CCL20, was higher than the expression level of SCC25. Our immunohistochemical investigation showed that CCL20 and CCR6 expression was associated with lymphatic vessel invasion and the number of CD163-positive macrophages. Recombinant human CCL20 induced the CD163 expression and promoted migration of THP-1. We also confirmed that a neutralizing anti-CCL20 antibody blocked the induction of CD163 expression by direct CM in THP-1. Moreover, ERK1/2 phosphorylation was associated with the CCL20-driven induction of CD163 expression in THP-1. ConclusionsTongue cancer cell-derived CCL20 that was induced by interaction with macrophages promotes CD163 expression on macrophages.
    Frontiers Media SA, 2021年06月, Frontiers in Oncology, 11
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi
    Most head and neck lymphoepithelial carcinomas (LECs) arise in the nasopharynx and harbor Epstein-Barr virus (EBV). LEC is also a rare subtype of the oral squamous cell carcinoma (SCC). Morphologically, LEC is defined as resembling non-keratinizing nasopharyngeal carcinoma, undifferentiated subtype. The histological features and pathogenesis of oral LEC are not established. We describe a case of tongue LEC with histopathological diagnostic difficulties. A 72-year-old Japanese female presented with a whitish change on her left-side tongue. The diagnosis was atypical epithelium; neoplastic change could not be ruled out by a biopsy. Although the lesion was monitored at our hospital per her request, invasive carcinoma was detected 11 months later. Microscopically, conventional SCC was observed with the characteristic features as LEC confined to the deep part of the lesion. We briefly discuss this unusual histological finding and make a novel proposal for distinguishing oral LEC from LECs in other regions based on these histological findings.
    2021年06月, Diagnostics (Basel, Switzerland), 11(6) (6), 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • Daisuke Takeda, Manabu Shigeoka, Tenyu Sugano, Nanae Yatagai, Takumi Hasegawa, Masaya Akashi
    2021年06月, DIAGNOSTICS, 11(6) (6), 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T Hasegawa, N Ueda, S I Yamada, S Kato, E Iwata, S Hayashida, Y Kojima, M Shinohara, I Tojo, H Nakahara, T Yamaguchi, T Kirita, H Kurita, Y Shibuya, S Soutome, M Akashi
    Pre-existing inflammation, corticosteroid therapy, periapical periodontitis, longer duration of denosumab therapy, and female sex were significantly associated with an increased risk of denosumab-related osteonecrosis of the jaw after tooth extraction in patients with cancer on oncologic doses of denosumab. A short drug holiday did not protect against this complication. INTRODUCTION: This study retrospectively investigated the relationship between various risk factors, including brief discontinuation of denosumab, and development of denosumab-related osteonecrosis of the jaw (DRONJ) after tooth extraction in patients with cancer who were receiving oncologic doses of this agent. METHODS: Data were collected on demographic characteristics, duration of denosumab therapy, whether or not denosumab was discontinued before tooth extraction (drug holiday), duration of discontinuation, presence of pre-existing inflammation, and whether or not additional surgical procedures were performed. Risk factors for DRONJ after tooth extraction were evaluated by univariate and multivariate analyses. RESULTS: A total of 136 dental extractions were performed in 72 patients (31 men, 41 women) with cancer who were receiving oncologic doses of denosumab. Post-extraction DRONJ was diagnosed in 39 teeth (28.7%) in 25 patients. Tooth extraction was significantly associated with development of DRONJ only in patients with pre-existing inflammation (odds ratio [OR] 243.77), those on corticosteroid therapy (OR 73.50), those with periapical periodontitis (OR 14.13), those who had been taking oncologic doses of denosumab for a longer period (OR 4.69), and in women (OR 1.04). There was no significant difference in the occurrence of DRONJ between patients who had a drug holiday before tooth extraction and those who did not. CONCLUSIONS: These findings suggest that inflamed teeth should be extracted immediately in patients with cancer who are receiving oncologic doses of denosumab. Drug holidays have no significant impact on the risk of DRONJ.
    2021年05月, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Manabu Shigeoka, Yu-ichiro Koma, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
    <b><i>Background:</i></b> The mortality of oral squamous cell carcinoma (OSCC) has remained high for decades; therefore, methods for early detection of OSCC are warranted. However, in the oral cavity, various mucosal diseases may be encountered, including reactive lesions and oral potentially malignant disorders, and it is difficult to differentiate OSCC from these lesions based on both clinical and histopathological findings. It is well known that chronic inflammation contributes to oral cancer development. Macrophages are among the most common inflammatory cells in cancer stromal tissue and have various roles in cancer aggressiveness. Although the roles of macrophages in cancer development have attracted attention, only a few studies have linked macrophages to carcinogenesis, particularly, oral precancerous lesions. <b><i>Summary:</i></b> This review article consists of 3 parts: first, we summarize current knowledge on macrophages in human various epithelial precancerous lesions, excluding the oral cavity, to show the importance and gaps in knowledge regarding macrophages in carcinogenesis; second, we review published data related to the role of macrophages in oral carcinogenesis; finally, we present a novel view on oral carcinogenesis, focusing on crosstalk between epithelial cells and macrophages. <b><i>Key Messages:</i></b> The biological features of macrophages in oral carcinogenesis differ drastically depending on the anatomical compartment that they infiltrate. Focusing on the alteration of macrophage infiltrating compartment may serve as a useful novel approach for studying the role of the macrophages in oral carcinogenesis and for gaining further insight into cancer prevention and early detection.
    S. Karger AG, 2021年05月, Pathobiology, 1 - 11
    研究論文（学術雑誌）

  • 早期舌癌治療のパラダイムシフトへ向けて-医科歯科病理の知の融合- 早期舌扁平上皮癌における頸部後発転移の新たな予測因子
    山川 延宏, 桐田 忠昭, 梅田 正博, 柳本 惣一, 大鶴 光信, 大倉 正也, 相川 友直, 太田 嘉英, 栗田 浩, 山田 慎一, 明石 昌也, 長谷川 巧, 上田 倫弘
    (一社)日本頭頸部癌学会, 2021年05月, 頭頸部癌, 47(2) (2), 142 - 142, 日本語

  • 口腔・中咽頭癌放射線治療326例における重症口腔粘膜炎および口腔カンジダ症発症に関連する因子
    西井 美佳, 五月女 さき子, 岩田 英治, 長谷川 巧実, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也
    (一社)日本口腔ケア学会, 2021年04月, 日本口腔ケア学会雑誌, 15(3) (3), 145 - 145, 日本語

  • Junya Yamashita, Masaya Akashi, Daisuke Takeda, Junya Kusumoto, Takumi Hasegawa, Kazunobu Hashikawa
    2021年03月, Cureus, 13(3) (3), e13833, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P. Izawa, Takeshi Inoue, Yoshitada Sakai, Masaya Akashi, Ken ichi Hirata, Kenji Okada
    2021年03月, CJC Open, 3(3) (3), 276 - 284
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Takumi Hasegawa, Masaki Kobayashi, Akira Tachibana, Naoki Takata, Toshiya Oko, Daisuke Takeda, Yoshiki Ishida, Tsuyoshi Fujita, Ikuko Goto, Junichiro Takeuchi, Masaya Akashi
    PURPOSE: In maxillary wisdom tooth extraction, the necessity of CT is unknown. The purpose of this study was to investigate whether CT adding to orthopantomography is useful for predicting oroantral perforation during maxillary third molar extraction. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analyses. We analyzed those of all patients and the patients who underwent CT, respectively. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) and Archer classification were assessed using panoramic radiography. The number of roots and vertical relationship were assessed using CT. RESULTS: A total of 604 out of 3299 patients underwent CT adding to orthopantomography. In all cases, multivariate analyses except for CT findings showed that the RS classification type III/IV and the Archer classification Type B/C/D in panoramic findings were significantly correlated with oroantral perforation as radiological findings. In cases for which CT was performed, multivariate analyses showed that one root (OR 12.87) and the vertical relationship Type D (OR 5.63) in CT findings, besides the RS classification type III/IV (OR 4.47) in panoramic findings, were significantly related to oroantral perforation. CONCLUSION: The RS classification and the Archer classification in panoramic findings can predict the risk of oroantral perforation. The usefulness of CT adding to orthopantomography is limited. However, when the relationship between the upper wisdom tooth and maxillary sinus floor (RS classification) is unclear, to check whether the number of roots is one and the apex of one root is projecting into the maxillary sinus in CT findings, is useful for the prediction.
    2021年03月, Oral and maxillofacial surgery, 25(1) (1), 7 - 17, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Izumi Saito, Takumi Hasegawa, Yumiko Kawashita, Shinichiro Kato, Shin-Ichi Yamada, Yuka Kojima, Nobuhiro Ueda, Masahiro Umeda, Yasuyuki Shibuya, Hiroshi Kurita, Tadaaki Kirita, Masaya Akashi
    OBJECTIVE: Radiotherapy (RT) carries a substantial risk for the development of osteoradionecrosis (ORN) of the jaw. This study was performed to investigate the relationship between dental extractions after RT and the development of ORN. MATERIAL AND METHODS: Thirty-two patients with head and neck cancer who underwent tooth extraction after RT were investigated for correlations between the development of ORN and various factors. RESULTS: Postextraction ORN was diagnosed in 12 (12.1%) teeth of 9 patients. The RT dose against the site of tooth extraction was 62.0 and 37.4 Gy in the ORN and Non-ORN groups, respectively (p < .001). The duration from RT to tooth extraction was 41.2 and 28.2 months in the ORN and Non-ORN groups, respectively (p = .025). Tooth extraction was significantly associated with ORN in patients with a high RT dose against the site (odds ratio = 1.231) and a longer duration of time from RT (odds ratio = 1.084). CONCLUSIONS: Extraction of non-restorable teeth and those with a poor prognosis should not necessarily be postponed even when patients are undergoing RT. However, clinicians should pay special attention to postoperative management after tooth extraction in patients with a high RT dose and longer time from RT.
    2021年03月, Oral diseases, 28(4) (4), 1181 - 1187, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Erina Kobayashi, Rika Amano, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akira Kimoto, Akiko Sakakibara, Masaya Akashi
    2021年02月, JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 21(3) (3), 856 - 864, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masato Ogawa, Seimi Satomi-Kobayashi, Naofumi Yoshida, Yasunori Tsuboi, Kodai Komaki, Nagisa Nanba, Kazuhiro P Izawa, Yoshitada Sakai, Masaya Akashi, Ken-Ichi Hirata
    BACKGROUND: Oral health is important for maintaining general health and is associated with components of physical frailty among the elderly. Oral health problems are common in hospitalized patients; however, no reports on oral health problems pertain to patients with cardiovascular diseases (CVD). The present study aimed to evaluate the association between oral health and physical frailty in these patients. METHODS: In this retrospective cohort study, we included consecutive patients admitted for CVD to our hospital between May 2014 and December 2018. Physical frailty was assessed using the Short Physical Performance Battery (SPPB). Oral health characteristics, such as the number of remaining teeth, denture use, occlusal support, and periodontal status, were assessed. RESULTS: In our cohort (n = 457), 111 (24.3%) patients had physical frailty. Univariate linear regression showed that the number of teeth present and the prevalence of occlusal support were significantly lower in patients with than without physical frailty. Pearson correlation indicated that the number of teeth significantly correlated with the nutritional status (r = 0.27) and SPPB score (r = 0.24), grip strength (r = 0.33), and 6-minute walking distance (r = 0.26). Multiple linear regression analysis showed that the number of teeth was independently associated with physical frailty after adjusting for confounders. CONCLUSIONS: Oral health was closely associated with physical frailty, and nutritional status in patients with CVD; thus, it could be an important screening marker for early frailty symptoms and a predictor of future malnutrition risk.
    2021年02月, Journal of cardiology, 77(2) (2), 131 - 138, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Daisuke Takeda, Motofumi Tanaka, Rika Amano, Izumi Saito, Yasumasa Kakei, Akira Kimoto, Takumi Fukumoto, Masaya Akashi
    PURPOSE: This study retrospectively investigated relationships among risk factors and post-hepatectomy surgical site infection (SSI) and other complications in patients who underwent hepatectomy for hepatocellular carcinoma (HCC). METHODS: We included 334 patients who underwent hepatectomies for liver cancers between January 2011 and December 2015 in this study. We evaluated risk factors for SSI and other post-hepatectomy complication, including demographic factors, preoperative factors, and preoperative intervention including oral management, perioperative factors, and length of hospital stay, with univariate and multivariate analyses. The oral management intervention included self-care instructions, extraction of infected teeth, removal of dental plaques and calculus (scaling), professional mechanical teeth cleaning, removal of tongue coating, and cleaning of dentures. SSI was defined in accordance with the guideline issued by the Centers for Disease Control and Prevention; it included purulent discharge from any incision or organ space within 30 days postoperatively, with or without microbiological evidence. Complications of grade II or greater, according to the Clavien-Dindo classification, were regarded as postoperative complications. RESULTS: We found bacterial infection of ascites (Odds ratio (OR) = 13.72), lack of preoperative oral management intervention (OR = 10.17), and severe liver fibrosis (OR = 2.76) to be associated with SSI and severe liver fibrosis (OR = 2.28), hypoalbuminemia (OR = 2.02), blood transfusion (OR = 1.86), and longer operation time (OR = 1.80) to be associated with postoperative complications. CONCLUSIONS: Preoperative oral management may reduce the risk of SSI in patients with HCC who undergo hepatectomy.
    2021年02月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(2) (2), 653 - 659, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takumi Hasegawa, Nanae Yatagai, Tatsuya Furukawa, Emi Wakui, Izumi Saito, Daisuke Takeda, Yasumasa Kakei, Akiko Sakakibara, Ken-Ichi Nibu, Masaya Akashi
    BACKGROUND: This prospective study investigated the change of swallowing ability using the Swallowing Ability Scale System (SASS) and swallowing-related quality of life (QOL) by Performance Status Scale for Head and Neck Cancer patients (PSS-H&N). This study also investigated the risk factors for postoperative dysphagia in patients who received reconstructive surgery for oral cancer. SUBJECTS AND METHODS: This study included 64 patients (33 men and 31 women) who underwent radical surgery with neck dissection and reconstructive surgery for oral cancers between July 2014 and February 2018. We evaluated risk factors for poor swallowing ability after treatment, including demographic factors, preoperative factors and perioperative factors, with univariate and multivariate analyses. The change of swallowing ability by the SASS and swallowing-related QOL by PSS-H&N were evaluated prospectively prior to the initiation of surgery within 1 week and at 1 and 3 months after treatment. RESULTS: Advanced T stage (T3, 4) (odds ratio (OR) = 79.71), bilateral neck dissection (OR = 20.66) and the resection of unilateral or bilateral suprahyoid muscles (OR = 17.00) were associated with poor swallowing ability after treatment. The scores for time for food intake and Eating in Public were associated with decrease of QOL in the poor group. CONCLUSIONS: We propose that clinicians consider the risk factors identified in this study and pay close attention to the management of oral cancer patients with reconstructive surgery.
    2021年01月, Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 50(1) (1), 4 - 4, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Junya Kusumoto, Atsushi Uda, Takeshi Kimura, Shungo Furudoi, Ryosuke Yoshii, Megumi Matsumura, Takayuki Miyara, Masaya Akashi
    BACKGROUND: In Japan, oral third-generation cephalosporins with broad-spectrum activity are commonly prescribed in the practices of dentistry and oral surgery. However, there are few reports on the appropriate use of antibiotics in the field of oral surgery. This study aimed to evaluate the appropriateness of antibiotic use before and after an educational intervention in the Department of Oral and Maxillofacial Surgery, Kobe University Hospital. METHODS: The use of oral antibiotics was investigated among inpatients and outpatients before and after an educational intervention conducted by the antimicrobial stewardship team. Additionally, the frequency of surgical site infection after the surgical removal of an impacted third mandibular molar under general anesthesia and the prevalence of adverse effects of the prescribed antibiotics were comparatively evaluated between 2013 and 2018. RESULTS: After the educational intervention, a remarkable reduction was noted in the prescription of oral third-generation cephalosporins, but increased use of penicillins was noted among outpatients. There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population. Despite the change in the pattern of antibiotic prescription, inpatients who underwent mandibular third molar extraction between 2013 and 2018 did not show a significant increase in the prevalence of surgical site infections (6.2% vs. 1.8%, p = .336) and adverse effects of drugs (2.1% vs. 0%, p = .466). CONCLUSIONS: This study suggests that the judicious use of oral antibiotics is possible through conscious and habitual practice of appropriate antibiotic use. However, further investigation is required to develop measures for appropriate use of oral antibiotics.
    2021年01月, BMC oral health, 21(1) (1), 20 - 20, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-Ichi Nibu, Ryohei Sasaki
    BACKGROUND: To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose-volume histogram (DVH) parameters. METHODS: We retrospectively reviewed the medical records of 616 patients with HNSCC treated with curative-intent or postoperative radiation therapy (RT) during 2008-2018. Patient-related (age, sex, history of smoking or alcohol use, diabetes mellitus, performance status, pre-RT dental evaluation, pre- or post-RT tooth extraction), tumor-related (primary tumor site, T-stage, nodal status), and treatment-related (pre-RT surgery, pre-RT mandible surgery, induction or concurrent chemotherapy, RT technique) variables and DVH parameters (relative volumes of the jaw exposed to doses of 10 Gy-70 Gy [V10-70]) were investigated and compared between patients with and without ORNJ. The Mann-Whitney U test was used to compare RT dose parameters. Univariate and multivariate Cox regression analyses were used to assess factors associated with ORNJ development. Kaplan-Meier analyses were performed for cumulative ORNJ incidence estimation. RESULTS: Forty-six patients (7.5%) developed ORNJ. The median follow-up duration was 40 (range 3-145) months. The median time to ORNJ development was 27 (range 2-127) months. DVH analysis revealed that V30-V70 values were significantly higher in patients with than in those without ORNJ. In univariate analyses, primary tumor site, pre-RT mandible surgery, post-RT tooth extraction, and V60 > 14% were identified as important factors. In multivariate analyses, V60 > 14% (p = 0.0065) and primary tumor site (p = 0.0059) remained significant. The 3-year cumulative ORNJ incidence rates were 2.5% and 8.6% in patients with V60 ≤ 14% and > 14%, respectively (p < 0.0001), and 9.3% and 1.4% in patients with oropharyngeal or oral cancer and other cancers, respectively (p < 0.0001). CONCLUSIONS: V60 > 14% and oropharyngeal or oral cancer were found to be independent risk factors for ORNJ. These findings might be useful to minimize ORNJ incidence in HNSCC treated with curative RT.
    2021年01月, Radiation oncology (London, England), 16(1) (1), 1 - 1, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Daisuke Takeda, Kazunobu Hashikawa, Manabu Shigeoka, Maki Kanzawa, Nanae Yatagai, Satomi Arimoto, Junya Kusumoto, Takumi Hasegawa, Hiroto Terashi, Masaya Akashi
    Advanced mandibular osteoradionecrosis (ORN) sometimes requires extended resection (e.g., hemimandibulectomy). Bacterial infection contributes to ORN pathogenesis. To control infection and determine the extent of debridement required, an understanding of bacterial spread within sites of mandibular ORN is important. The current study used a histopathological approach to assess bacterial colonization in the mandibular condyle and elucidate possible paths of bacterial spread towards the mandibular condyle. Four hemimandibulectomy specimens were selected. Areas of bone destruction were macroscopically assessed and confirmed using hematoxylin and eosin staining. Bacterial presence within mandibular condyle was confirmed with Gram staining. Bone exposure was observed in the molar area in all specimens. Macroscopic bone destruction was apparent especially near the medial side of the cortical wall. Gram staining revealed bacterial colonization of the mandibular condyle in three of the four specimens. In conclusion, bacteria tended to spread posteriorly and through the medial side of the mandibular cortical wall. In patients with advanced ORN, the potential for bacterial colonization of the mandibular condyle should be considered during treatment.
    2021年, International journal of dentistry, 2021, 9998397 - 9998397, 英語, 国際誌
    研究論文（学術雑誌）

  • Nanae Yatagai, Takumi Hasegawa, Rika Amano, Izumi Saito, Satomi Arimoto, Daisuke Takeda, Yasumasa Kakei, Masaya Akashi
    INTRODUCTION: In recent years, the tumour immunosuppressive mechanism has attracted attention as a cause of tumour chemoresistance. Although chemoresistance and immunosuppression of tumours have been reported to be associated with a hypoxic environment, effective treatments to improve hypoxia in tumours have not yet been established. We have previously applied carbon dioxide (CO2) to squamous cell carcinoma and have shown that improvement in local oxygenation has an antitumour effect. However, the effects of local CO2 administration on tumour immunosuppression, chemoresistance, and combination with chemotherapy are unknown. In this study, we investigated the effects of local CO2 administration on squamous cell carcinoma and the effects of combined use with chemotherapy, focusing on the effects on tumour immunosuppressive factors. METHODS: Human oral squamous cell carcinoma (HSC-3) was transplanted subcutaneously into the back of a nude mouse, and CO2 and cisplatin were administered. After administration twice a week for a total of 4 times, tumours were collected and the expression of tumour immunosuppressive factors (PD-L1, PD-L2, and galectin-9) was evaluated using real-time polymerase chain reaction and immunostaining. RESULTS: Compared with the control group, a significant decrease in the mRNA expression of PD-L1 was observed in both, CO2-treated and combination groups. Similarly, the expression of PD-L2 and galectin-9 decreased in the CO2-treated and combination groups. Furthermore, immunostaining also showed a significant decrease in the protein expression of tumour immunosuppressive factors in the CO2-treated and combination groups. CONCLUSION: It was confirmed that the tumour immunosuppressive factors decreased due to local CO2 administration to the mouse model. CO2 administration has the potential to improve the hypoxic environment in tumours, and combined use with chemotherapy may also improve tumour immunosuppression.
    2021年, BioMed research international, 2021, 5568428 - 5568428, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Junya Kusumoto, Naoki Takata, Shungo Furudoi, Akira Tachibana, Masaya Akashi
    BACKGROUND: Necrotizing fasciitis (NF) is an acute and life-threatening soft-tissue infection however rarely seen in oro-cervical region. Therefore, the details of oro-cervical NF (OCNF) are not well known. The purpose of this study was to investigate the characteristics of OCNF by comparing it with severe cellulitis of oro-cervical region (OCSC) or NF of other body regions (e.g., limb, perineum, and trunk) (BNF), respectively. MATERIALS AND METHODS: At first, various risk factors for OCNF in oro-cervical severe infection (OCSI; composed of OCNF and OCSC), including neutrophil-to-lymphocyte ratio (NLR) and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, were investigated by univariate and multivariate analyses. Next, the differences between OCNF and BNF, including inflammatory markers and mortality, were investigated. RESULTS: In the present study, 14 out of 231 OCSI patients had OCNF. Multivariate analyses of OCSI patients showed that NLR ≥15.3 and LRINEC score ≥6 points were significantly related to OCNF. During the same period, 17 patients had BNF. The OCNF group had significantly higher inflammatory markers than the BNF group when diagnosis, but significantly lower clinical stages at the time and mortality as outcomes. CONCLUSION: We found that compared to BNF, OCNF can be detected at lower clinical stage by using indexes, such as NLR and LRINEC score, besides clinical findings, which may help contributing to patient's relief.
    2021年, PloS one, 16(12) (12), e0260740, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Ryuichiro Funahara, Sakiko Soutome, Madoka Funahara, Shoma Tsuda, Takumi Hasegawa, Masahiro Umeda, Masaya Akashi
    2021年, Supportive Care in Cancer
    研究論文（学術雑誌）

  • Wensu Huang, Masaya Akashi, Takuro Nishio, Noriyuki Negi, Akira Kimoto, Takumi Hasegawa
    INTRODUCTION: Elongated mandibular coronoid process is a rare condition defined as enlargement of the coronoid process. The only useful way to treat the mouth-opening limitation is resection of the elongated coronoid process. Four-dimensional CT (4DCT; three spatial dimensions plus time axis) is a novel imaging technique. Its usefulness of for evaluation of dynamic movements such as joint motion has been reported. Here, we show the potential usefulness of 4DCT evaluation in a patient with elongated mandibular coronoid process. CASE PRESENTATION: A 59-year-old female who suffered from mouth-opening difficulty and pressure during mouth opening was referred to our department. Elongation of the right coronoid process was evident in a panoramic X-ray image. The mandibular movement and temporal muscle motility before and after coronoidectomy in this patient on 4DCT could be evaluated. CONCLUSIONS: 4DCT is useful in the diagnosis and surgical outcome of elongated coronoid process.
    2020年12月, Oral and maxillofacial surgery, 24(4) (4), 515 - 520, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Eiji Iwata, Akira Tachibana, Junya Kusumoto, Naoki Takata, Takumi Hasegawa, Masaya Akashi
    BACKGROUND: Various antibiotics and analgesics have been reported to interact with warfarin. Reports that investigate the effects of medication taken for just a few days during tooth extraction on the prothrombin time-international normalized ratio are rare. METHODS: A total of 110 patients receiving long-term stable warfarin therapy underwent tooth extraction without interruption of warfarin treatment. INR values were measured 1 month before the tooth extraction, the day of the extraction, and 1 week after the extraction. We investigated the changes in INR values between the day of extraction and 1 week after extraction, as well as the various risk factors for increases in INR values. RESULTS: Before and after tooth extraction, the number of patients taking cefcapene pivoxil, amoxicillin, and azithromycin was 57, 36, and 8, respectively. Nine patients were administered ampicillin before tooth extraction and received amoxicillin after their tooth extraction. One week after tooth extraction, the INR values increased beyond the therapeutic range in 3 out of 110 patients (2.7%). The INR values before tooth extraction in these three patients were close to 3.0. The INR value increased by more than twice as much in 1 out of 110 patients (0.9%). CONCLUSION: Our results suggest that prophylactic antibiotic administration has little effect on INR values when patients on stable warfarin therapy undergo tooth extraction. Surgeons have to take attention if the patients whose INR values are close to 3.0 before their extraction.
    2020年11月, BMC oral health, 20(1) (1), 331 - 331, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例
    高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也
    (一社)日本口腔感染症学会, 2020年11月, 日本口腔感染症学会雑誌, 27(2) (2), 61 - 66, 日本語

  • 生体腎移植後患者に発症した歯性感染症によるガス壊疽の1例
    高田 直樹, 橘 進彰, 岩田 英治, 榎本 由依, 明石 昌也
    (一社)日本口腔感染症学会, 2020年11月, 日本口腔感染症学会雑誌, 27(2) (2), 61 - 66, 日本語

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代
    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, 日本語

  • Manabu Shigeoka, Satomi Arimoto, Masaya Akashi
    Background: Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining. Methods: JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation. Results: Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood endothelial cell-cell junctions. JCAD expression was more evident in microvessels and arteries in areas affected by inflammation. Conclusions: The localization of JCAD at endothelial cell-cell junctions was confirmed in human tissues. JCAD expression may be affected by pathological conditions.
    2020年10月, Heliyon, 6(10) (10), e05121, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Daiki Takahashi, Yusuke Demizu, Sung Chul Park, Yoshiro Matsuo, Nor Shazrina Sulaiman, Kazuki Terashima, Sunao Tokumaru, Masaya Akashi, Tomoaki Okimoto
    This study aimed to determine the maximum tolerance dose (MTD) and to estimate the recommended dose (RD) of concomitant S-1 with carbon-ion radiotherapy (RT) for sinonasal squamous cell carcinoma (SCC). Nine patients with sinonasal SCC received carbon-ion RT with escalating doses of S-1 according to phase I methods. Doses of 40, 60 and 80 mg/m2/day were administered twice daily in dose levels 1, 2 and 3, respectively, from days 1 to 14 and 22 to 35. Carbon-ion RT was administered at a dose of 70.4 Gy (relative biological effectiveness) in 32 fractions, 5 days a week. Two patients developed grade 3 acute dermatitis. However, none developed dose-limiting toxicities. Therefore, the MTD of S-1 could not be determined; the RD was estimated to be 80 mg/m2/day with concurrent carbon-ion RT. Partial response and stable disease were noted in 5 and 4 patients, respectively. The 2-year overall survival and local control rates were 56 and 74%, respectively. Overall, 2 patients developed ≥grade 3 late toxicities; among them, 1 patient developed grade 3 cataract and the other developed grade 4 cataract, optic nerve disorder and hearing impairment. To the best of our knowledge, this phase I study is the first clinical trial to evaluate concomitant S-1 with carbon-ion RT for sinonasal SCC. The MTD of S-1 could not be determined, and the RD was estimated to be 80 mg/m2/day. This study demonstrated a manageable safety profile for this combination. The observed outcomes may facilitate further evaluation of this novel therapy.
    2020年09月, Journal of radiation research, 61(5) (5), 733 - 739, 英語, 国際誌
    研究論文（学術雑誌）

  • 膵頭十二指腸切除術における周術期口腔機能管理の術後合併症予防効果
    山口 泰平, 高島 裕之, 森田 麻希, 渋谷 恭之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 兒島 由佳, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 森 和代, 於保 孝彦
    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 114 - 114, 日本語

  • 周術期口腔ケアによる胃癌術後合併症予防効果に関する臨床的検討
    高島 裕之, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 延原 浩, 長谷川 巧実, 明石 昌也, 上田 順宏, 下辻 寛子, 桐田 忠昭, 小西 尚晃, 中原 寛和, 山田 慎一, 栗田 浩, 山口 泰平, 森 和代, 渋谷 恭之
    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 123 - 123, 日本語

  • 口腔ケアのエビデンスを検証するためにはどのような研究をすればよいのか アカデミア臨床研究環境のこれまで 臨床研究法施行の背景
    筧 康正, 長谷川 巧実, 明石 昌也
    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 53 - 54, 日本語

  • 大腸癌術後合併症に対する周術期口腔機能管理の予防効果に関する多施設共同研究
    延原 浩, 五月女 さき子, 林田 咲, 村田 真穂, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 小西 尚晃, 中原 寛和, 上田 順宏, 下辻 寛子, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代
    (一社)日本口腔ケア学会, 2020年09月, 日本口腔ケア学会雑誌, 14(3) (3), 122 - 122, 日本語

  • Ryuichi Itoh, Shin ichi Yamada, Takumi Hasegawa, Nobuhiro Yamakawa, Yuya Denda, Hiroki Otagiri, Masaya Okura, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Yoshihide Ota, Masahiro Umeda, Hiroshi Kurita
    2020年09月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 32(5) (5), 356 - 359
    研究論文（学術雑誌）

  • Manabu Shigeoka, Yu-Ichiro Koma, Maki Kanzawa, Masaya Akashi, Hiroshi Yokozaki
    Oral lichenoid conditions (OLC), including oral lichen planus (OLP), oral lichenoid lesions and oral lichenoid dysplasia, differ in pathogenesis and biological malignancy. However, distinguishing them based on clinical or histological features is difficult. It is well known that CD163+ macrophages are associated with oral cancer aggressiveness. We recently demonstrated that CD163+ macrophages of noncancerous lesions infiltrate the stroma, not the intraepithelial area. In this report, we describe a case of OLC that was not detected as malignant by the first local biopsy. Furthermore, we evaluated the malignant potency of OLC by retrospectively comparing the histological findings between local biopsy and resected specimens focusing on CD163+ macrophages. A 72-year-old man with a white lesion in the unilateral buccal mucosa was diagnosed with OLP through the biopsy although invasive cancer was detected two years later. Intraepithelial CD163+ macrophages were found not only on the resected specimen but also biopsy. This is the first report to demonstrate that intraepithelial CD163+ macrophages may be noteworthy indicators to identify the malignant potency of OLC.
    MDPI AG, 2020年08月, Diagnostics (Basel, Switzerland), 10(9) (9), 624 - 624, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 全身麻酔導入時にロクロニウムによるアナフィラキシーをきたした1例
    高田 直樹, 橘 進彰, 高井 美玲, 榎本 由依, 岩田 英治, 黄 文蘇, 明石 昌也
    (一社)日本有病者歯科医療学会, 2020年08月, 有病者歯科医療, 29(3) (3), 75 - 80, 日本語

  • Takumi Sato, Junya Kusumoto, Daisuke Takeda, Megumi Kishimoto, Masahiko Kashin, Shungo Furudoi, Masaya Akashi
    OBJECTIVES: One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality of life (QOL). This study aimed to identify symptoms that negatively affect QOL in patients with unhealed MRONJ or ORN. STUDY DESIGN: This cross-sectional study included patients who were previously diagnosed with MRONJ or ORN and who underwent treatment at the Kobe University Hospital between June 2015 and February 2016. Patient QOL was measured by using the Oral Health Impact Profile (OHIP-14). The predictor variable was disease status (stage and healing). The outcome variable was OHIP-14. One-way analysis of variance and Tukey's test were performed. RESULTS: The study included 74 patients (37 men and 37 women; mean age 70 years). Although there was no significant difference between the OHIP-14 scores of unhealed MRONJ and ORN (stages 1-3) and those of healed ones, the "worsened sense of taste" resulted in significant differences among stages in patients with unhealed MRONJ (P = .027) and the "painful mouth aching" in patients with unhealed ORN (P = .041). CONCLUSIONS: Worsened sense of taste and pain negatively affected QOL in patients with unhealed MRONJ and ORN.
    2020年08月, Oral surgery, oral medicine, oral pathology and oral radiology, 130(2) (2), 175 - 180, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • S. Yanamoto, Y. Denda, Y. Ota, T. Hasegawa, M. Akashi, M. Okura, S. I. Yamada, H. Kurita, N. Yamakawa, T. Kirita, M. Ueda, M. Umeda
    2020年07月, International Journal of Oral and Maxillofacial Surgery, 49(7) (7), 848 - 853
    研究論文（学術雑誌）

  • Shin-Ichi Yamada, Takumi Hasegawa, Sakiko Soutome, Hitoshi Yoshimura, Masaaki Miyakoshi, Nobuhiro Ueda, Kenjiro Okamoto, Sumiyo Hishida, Satoshi Rokutanda, Hirokazu Nakahara, Shigeyuki Fujita, Masaya Akashi, Yoshimasa Kitagawa, Tadaaki Kirita, Yasuyuki Shibuya, Masahiro Umeda, Hiroshi Kurita
    Postoperative hemorrhage after tooth extraction is a critical and clinically important issue for clinicians and patients receiving anticoagulants. The purpose of the present study was to investigate the prevalence of and risk factors for postoperative hemorrhage after lower third molar extraction in Japanese patients receiving warfarin therapy. A total of 142 patients who underwent lower third molar extraction between January 2010 and December 2016 were included, and their medical records were retrospectively reviewed. The prevalence of and risk factors for postoperative hemorrhage were investigated. The prevalence of postoperative hemorrhage after lower third molar extraction was significantly higher in patients receiving warfarin than in healthy subjects (21.8% vs 0.7%, P < 0.001). The cutoff value for PT-INR was 2.11 based on a receiver-operating characteristic analysis. A multivariate analysis indicated that an elevated PT-INR value [hazard ratio (HR) 3.798, 95% confidence interval (CI) 1.400-10.467, P < 0.01], preoperative antibiotic administration (HR 4.434, 95% CI 1.591-14.775, P < 0.01), difficulties with intraoperative hemostasis (HR 16.298, 95% CI 2.986-110.677, P < 0.01), and higher serum creatinine levels (HR 7.465, 95% CI 1.616-39.576, P < 0.05) are significant predictors of postoperative hemorrhage after lower third molar extraction. Multivariate correlations were observed between risk factors including an elevated PT-INR value, preoperative antibiotic administration, and higher serum creatinine levels, and postoperative hemorrhage after lower third molar extraction in patients receiving warfarin therapy. Clinicians need to consider these risk factors for postoperative hemorrhage after the lower third molar extraction and monitor PT-INR in patients receiving warfarin therapy.
    2020年07月, Odontology, 108(3) (3), 462 - 469, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara, Masaya Akashi
    BACKGROUND: Prognostic biomarkers provide essential information about a patient's overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the process, such as prolonged time for analysis. In view of the need for convenient and non-invasive prognostic biomarkers for oral cancer, we aimed to investigate the prognostic values of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio in patient survival. We also aimed to explore the associations of these ratios with the clinicopathologic characteristics of Japanese oral squamous cell carcinoma patients. METHODS: This study was a non-randomized retrospective cohort study in a tertiary referral center. We included 433 patients (246 men, 187 women) who underwent radical surgery for oral cancers between January 2001 and December 2013. We evaluated various risk factors for poor prognosis including neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio with univariate and multivariate analyses. The disease-specific survival and overall survival rates of patients were compared among the factors and biomarkers. RESULTS: In multivariable Cox proportional hazards analysis, high neutrophil-to-lymphocyte ratio (hazard ratio 2.87, 95% confidence interval 1.59-5.19, P <  0.001), moderately or poorly differentiated histology (hazard ratio 2.37, 95% confidence interval 1.32-4.25, P <  0.001), and extranodal extension (hazard ratio 1.95, 95% confidence interval 1.13-3.35, P = 0.016) were independent predictors of disease-specific survival. High neutrophil-to-lymphocyte ratio (hazard ratio 2.30, 95% confidence interval 1.42-3.72, P <  0.001), moderately or poorly differentiated (hazard ratio 1.72, 95% confidence interval 1.07-2.76, P = 0.025), and extranodal extension (hazard ratio 1.79, 95% confidence interval 1.13-2.84, P = 0.013) were independent predictors of overall survival. CONCLUSIONS: Neutrophil-to-lymphocyte ratio might be a potential independent prognostic factor in Japanese oral squamous cell carcinoma patients.
    2020年06月, BMC cancer, 20(1) (1), 568 - 568, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shin-Ichi Yamada, Takumi Hasegawa, Kohei Okuyama, Nobuhiro Yamakawa, Masaya Okura, Masao Hashidume, Souichi Yanamoto, Masaya Akashi, Tadaaki Kirita, Masahiro Umeda, Hiroshi Kurita
    OBJECTIVES: The present study investigated the clinical significance of the G8 screening tool in elderly oral squamous cell carcinoma (OSCC) patients using a multicenter analysis. MATERIALS AND METHODS: The medical records of 438 primary OSCC patients aged 75 years and older were retrospectively reviewed. To examine the clinical significance of the G8 screening tool in elderly OSCC patients, self-reliance (SR) rates and prognostic factors were statistically analyzed. RESULTS: The mean score of the G8 screening tool was 10.9 ± 2.93. The SR cut-off value of the G8 score was 9.5 in a receiver operating characteristic curve analysis. Five-year overall survival rates were 40.1% in patients with a G8 score < 9.5 and 58.4% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year cancer-specific rates were 34.3% in patients with a G8 score < 9.5 and 55.7% in those with a G8 score ≥ 9.5 (p < 0.01). Five-year SR rates were 40.7% in patients with a G8 score < 9.5 and 55.3% in those with a G8 score ≥ 9.5 (p < 0.05). A multivariate analysis identified an advanced age (≥ 80 vs < 80; HR, 1.437; 95%CI, 1.181-1.843; p < 0.01), poorer ECOG-PS (2-4 vs 0-1; HR, 1.560; 95%CI, 1.14-2.106; p < 0.01), and standard treatment (non-standard therapy vs standard therapy; HR, 0.598; 95%CI, 0.405-0.910; p < 0.05) as significant independent prognostic factors for SR. A lower G8 score was associated with poorer SR (≥ 9.5 vs < 9.5; HR, 0.765; 95%CI, 0.575-1.034; p = 0.081). CONCLUSION: The clinical significance of the G8 score for elderly OSCC patients was demonstrated and its combination with ECOG-PS may be useful for assessing their prognoses.
    2020年06月, Clinical oral investigations, 24(6) (6), 1953 - 1961, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yasumasa Kakei, Hirokazu Komatsu, Tsutomu Minamikawa, Takumi Hasegawa, Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Ken-Ichi Nibu, Masaya Akashi
    BACKGROUND: No clear consensus has been reached on the indication of supraomohyoid neck dissection (SOHND) for clinically positive lymph-node metastasis. PATIENTS: Consecutive 100 patients with previously untreated oral cancer treated at Kobe University Hospital were included in this study. All patients were clinically staged as anyTN1M0 and underwent radical dissection of the primary site and level I-V neck dissection as the initial treatment. RESULTS: None of the 100 patients had pathological lymph-node metastasis (pLN) to level V. pLN to level IV was observed in two patients with tongue cancer in whom clinical lymph-node metastasis was preoperatively observed at level II. CONCLUSIONS: Level V may be excluded in the neck dissection for patients with N1 oral cancers. Level IV dissection should be considered in the patient with tongue cancer and clinical lymph-node metastasis at level II.
    2020年06月, International journal of clinical oncology, 25(6) (6), 1067 - 1071, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
    OBJECTIVE: Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163+ macrophages in oral carcinogenesis. Herein we sought to determine whether CD163+ macrophages in biopsy specimens of oral leukoplakia help identify the overall histological nature of the lesion. PATIENTS AND METHODS: Twenty-six patients with tongue leukoplakia who underwent a histological examination by both a preoperative local biopsy and consecutive total excision were enrolled. We evaluated clinicopathological factors and the expression of CD163+ macrophages based on a retrospective comparison of the histological diagnostic concordance between the biopsies and excisions. RESULTS: Seventeen patients (diagnostic-agreement group) were diagnosed with squamous intraepithelial lesion based on both the biopsy and the excision. Nine patients (diagnostic-discrepancy group) were diagnosed with invasive cancer by excision, although invasive cancer was not observed in their biopsy specimens. Compared to the diagnostic-agreement group, the diagnostic-discrepancy group had more tongue leukoplakia with non-homogenous or high numbers of intraepithelial CD163+ macrophages. CONCLUSION: The evaluation of intraepithelial CD163+ macrophages in local biopsy specimens from tongue leukoplakia patients is a promising tool for cancer screening.
    2020年04月, Oral diseases, 26(3) (3), 527 - 536, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Mika Nishii, Sakiko Soutome, Akiko Kawakita, Hirokazu Yutori, Eiji Iwata, Masaya Akashi, Takumi Hasegawa, Yuka Kojima, Madoka Funahara, Masahiro Umeda, Takahide Komori
    PURPOSE: The present retrospective multicenter study intended to investigate the factors associated with severe oral mucositis and candidiasis in patients undergoing radiotherapy for oral and oropharyngeal carcinomas. METHODS: A total of 326 patients who underwent radiotherapy for oral and oropharyngeal cancers were enrolled in the study. The patients' age, sex, body mass index, primary site, diabetes, serum albumin, creatinine, hemoglobin, leukocyte and lymphocyte, concurrent cisplatin or cetuximab, method of radiation, total radiation dose, feeding route, use of spacers, pilocarpine hydrochloride, and corticosteroid ointment were examined, and the associations of each variable with oral mucositis and candidiasis were analyzed by multivariate Cox regression analysis. RESULTS: Grade 3 oral mucositis occurred in 136 (41.7%) patients. Male sex, oropharyngeal cancer, low hemoglobin levels, low leukocytes or lymphocytes, concurrent cisplatin or cetuximab, and oral feeding were found to be significantly associated with a higher incidence of severe oral mucositis. Oral candidiasis occurred in 101 (31.0%) patients. Oropharyngeal cancer, low leukocyte count, and oral mucositis of grade 2 or higher were found to be significantly associated with a higher incidence of oral candidiasis. The use of a topical steroid ointment was not found to be a risk factor for oral candidiasis. CONCLUSIONS: The present retrospective study demonstrated that certain factors may predispose patients with oral and oropharyngeal cancers receiving radiotherapy to develop severe oral mucositis and oral candidiasis. A preventive strategy for severe oral mucositis needs to be established in the future for high-risk cases.
    2020年03月, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 28(3) (3), 1069 - 1075, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, Yoshihiro Kakeji
    BACKGROUND: Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health. OBJECTIVE: The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy. METHODS: This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years). RESULTS: The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22-2.87), in addition to clinical T stage and preoperative serum albumin. CONCLUSION: Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.
    2020年03月, Annals of surgical oncology, 27(3) (3), 683 - 690, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Manabu Shigeoka, Yu-Ichiro Koma, Takayuki Kodama, Mari Nishio, Masaya Akashi, Hiroshi Yokozaki
    Oral verruciform xanthoma (OVX) is an uncommon benign lesion that is characterized histologically by the accumulation of several foamy macrophages in the lamina propria papillae. The pathogenesis of OVX has not been completely elucidated, although the significance of macrophage polarization (M1, tumor suppression; and M2, tumor promotion) and the contribution of M2 macrophages to angiogenesis are well established. This study investigated the role of foamy macrophages in OVX, with a focus on angiogenesis. Four patients who underwent surgical excision or total excisional biopsy for OVXs were enrolled in this study. We evaluated the expression of the macrophage markers CD68 (broad) and CD163 (M2) and the CD34-positive microvessel density (MVD) of OVXs. The foamy macrophages of all patients exhibited positivity to CD68 and CD163. We evaluated the MVD and the expression of the vascular endothelial growth factor (VEGF) based on histological architecture. The MVD of all OVX cases was significantly higher than that of the corresponding normal epithelia. Interestingly, the MVD of verrucous-type OVX cases was higher than that of the other type. VEGF was expressed on foamy macrophages in all cases. Overall, the foamy macrophages expressing CD163 were associated with the morphogenesis of OVX through the process of angiogenesis by VEGF expression.
    2020年02月, Dentistry journal, 8(1) (1), 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masahiko Kashin, Yasumasa Kakei, Shun Teraoka, Takumi Hasegawa, Akinobu Yamaguchi, Takao Fukuoka, Ryohei Sasaki, Masaya Akashi
    Cetuximab, an epidermal growth factor receptor inhibitor (EI), is currently the only targeted molecular therapy used in combination with radiotherapy for head and neck squamous cell carcinoma (HNSCC). Gold nanoparticles (AuNPs) are expected to enhance radiotherapy effects in cancers. To investigate whether AuNPs combined with AG1478, an EI, enhanced irradiation effects on HNSCC cells, we first examined AG1478 adsorption on AuNP surfaces, using surface-enhanced Raman scattering, which indicated an adsorption equilibrium of AG1478 to AuNPs. We then used transmission electron microscopy to find internalization rates of AuNP alone and AuNP+AG1478; we found that intracellular uptake of AuNP alone and AuNP+AG1478 did not significantly differ. We compared cell numbers, proliferation, apoptosis, and migration between control cells and those treated with or without 60 nm AuNP (1.0 nM), AG1478 (0.5 μM), and irradiation (4 Gy). We found that AuNP+AG1478 inhibited proliferation more than AG1478 alone; the combination of irradiation+AuNP+AG1478 significantly reduced total cell numbers compared with the combination of irradiation+AuNP; AuNP+AG1478 increased apoptotic reaction to irradiation; the combinations of AuNP+AG1478 and irradiation+AuNP induced more apoptosis than AG1478+irradiation. Whereas AuNP+AG1478 enhanced cytotoxicity in human HNSCC cells by inhibiting proliferation, irradiation+AuNP enhanced cytotoxicity by inducing apoptosis.
    2020年, BioMed research international, 2020, 1281645 - 1281645, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Chizu Tateishi, Masaya Akashi, Shungo Furudoi, Takahide Komori
    OBJECTIVE: The present study investigated the effect of low-intensity pulsed ultrasound (LIPUS) on long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy (IVRO). STUDY DESIGN: Patients undergoing IVRO were randomly assigned to the LIPUS group (n = 12) or the control group (n = 9) after surgery. LIPUS treatments were applied daily to the cleavage space between bone fragments for 3 weeks. We observed 3-dimensional quantitative color mapping of the whole mandible created by computed tomography (CT) data at 1 month, 6 months, and 1 year postoperatively. On the basis of CT values, the color grades were classified as D1 to D5 by using the Misch criteria. We then calculated mean CT values and rated each color grade in different selection ranges. RESULTS: The mean CT values of the LIPUS group were significantly higher than those of the control group at 1 month, 6 months and 1 year postoperatively (P < .01). The color grades of the cleavage between bone fragments increased from D5 to D1 over time. CONCLUSIONS: Our results indicated that LIPUS promoted osseous healing after IVRO, thus improving bone density and offering clinical benefits.
    2019年12月, Oral surgery, oral medicine, oral pathology and oral radiology, 128(6) (6), 581 - 589, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 西井 美佳, 五月女 さき子, 長谷川 巧実, 柚鳥 宏和, 川北 晃子, 兒島 由佳, 船原 まどか, 梅田 正博, 明石 昌也, 古森 孝英
    (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31(3) (3), 111 - 116, 日本語
    [査読有り]

  • 兒島 由佳, 河岡 有美, 川下 由美子, 山田 慎一, 栗田 浩, 長谷川 巧実, 古森 孝英, 明石 昌也, 上田 順宏, 桐田 忠昭, 高島 裕之, 渋谷 恭之, 梅田 正博
    (一社)日本口腔腫瘍学会, 2019年09月, 日本口腔腫瘍学会誌, 31(3) (3), 117 - 120, 日本語

  • Yumi Muraki, Masaya Akashi, Yasuo Ejima, Takumi Hasegawa, Daisuke Miyawaki, Hirotaka Shinomiya, Mika Nishii, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    BACKGROUND: The purpose of this study was to investigate the effectiveness of dental intervention before and after radiation therapy (RT) for head and neck malignancy on prevention of osteoradionecrosis (ORN) of the jaws. METHODS: This is a single-arm prospective study according to intervention protocol of prophylactic dental extraction before RT and routine follow-up after RT. The primary endpoint was the occurrence of jawbone exposure during the first 2 years after RT. RESULTS: Sixty-seven patients were assessed. Before RT, 144 teeth among 39 patients (58%) were prophylactically extracted. The occurrence of transient jawbone exposure during the first 2 years after RT was 7%. Because those jawbone exposures healed with intervention after RT, no jawbone exposure was found at 2 years after RT. CONCLUSIONS: Dental intervention both before and after RT seemed to be important to prevent ORN development. Further studies in larger cohorts are necessary.
    2019年09月, Oral and maxillofacial surgery, 23(3) (3), 297 - 305, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori
    BACKGROUND AND OBJECTIVE: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. METHODS: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal-Wallis test, and Scheffe test were used in statistical analyses. RESULTS: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59-2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3-1.8, and ≥1.8. CONCLUSION: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.
    2019年07月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 72(7) (7), 1135 - 1141, 英語, 国際誌
    研究論文（学術雑誌）

  • Masaya Akashi, Kousuke Matsumoto, Daisuke Takeda, Junya Yamashita, Nanae Yatagai, Kazunobu Hashikawa, Takahide Komori
    Dental rehabilitation with osseointegrated implants in reconstructed mandibles is a common procedure, but the technique still requires improvement, especially in its reliability and technical simplification. We herein report dental rehabilitation of a free fibula-reconstructed mandible with scar contracture. A vestibuloplasty technique with application of a polyglycolic acid (PGA) sheet is described. The implants were inserted into a viable fibula flap with severe scar contracture of the overlying epithelium resulting from vascular instability in skin paddle. Only the fibula periosteum was sutured after implant insertion; exposed surfaces were covered with a combination of PGA sheet and fibrin sealant. The area with PGA sheet coverage gradually healed with moderate contracture. The epithelium around the almost implants became immobilized. The implant-supported removable partial denture with custom titanium bar was acceptable. Dental rehabilitation is possible for reconstructed mandibles with severe scar contracture. Application of a PGA sheet may be useful for vestibuloplasty in patients with reconstructed mandibles.
    2019年06月, Dentistry journal, 7(3) (3), 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Daisuke Takeda, Takumi Hasegawa, Izumi Saito, Satomi Arimoto, Masaya Akashi, Takahide Komori
    PURPOSE: Evaluation of the inner aspect of the maxillary sinus is important for the success of a sinus lift procedure. The most common surgical complication is perforation of the Schneiderian membrane, which is thought to occur because of the presence of maxillary sinus septa. Therefore, we retrospectively investigated the incidence and morphology of maxillary sinus septa using multiplanar reformatted computed tomographic (CT) images from dentate Japanese patients. METHODS: A total of 276 patients and 552 maxillary sinus segments were evaluated. The maxillary sinus septa were divided into four locations: forefront, anterior, middle, and posterior. The heights of the septa were measured at three sites from the deepest point of the sinus floor: lateral, mid-point, and medial. RESULTS: Sinus septa were identified in 191 of 552 (34.6%) maxillary sinus segments obtained from 111 of 276 (40.2%) patients. One unilateral septum was most commonly detected, and the sinus septa were most often located in the middle of the maxillary sinus. The average height of the identified septa was 8.69 ± 4.68 mm (mean ± standard deviation). CONCLUSION: Multiplanar reformatted CT images can identify maxillary sinus septa in any plane. The height of maxillary sinus septa in the dentate maxillae was higher than detected in previous studies. Appropriate treatment planning using CT images should be considered to prevent surgical complications.
    2019年06月, Oral and maxillofacial surgery, 23(2) (2), 233 - 237, 英語, 国際誌
    研究論文（学術雑誌）

  • Akiko Sakakibara, Junya Kusumoto, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Shungo Furudoi, Kazunobu Hashikawa, Takahide Komori
    OBJECTIVE:  Musculocutaneous flap reconstruction surgery is one of the standard procedures following head and neck cancer resection. However, no previous studies have classified flaps in terms of muscle and fat or examined them after long-term follow-up. The purpose of this study was to estimate the fat and muscle volume changes in musculocutaneous flaps during long-term follow-up. METHODS:  We conducted a retrospective analysis of 35 patients after musculocutaneous flap reconstruction. The total, fat, and muscle volumes of the musculocutaneous flaps were measured using 3-dimensional images. Changes in flap volumes over time (1 month, 1 year [POY1], and 5 years [POY5] postoperatively) were assessed. Flap persistence was calculated using flap volumes at 1 month after reconstruction for reference. RESULTS:  Flap persistence at POY5 was 42.0% in total, 64.1% in fat, and 25.4% in muscle. Muscle persistence was significantly decreased (p < 0.0001). In a multiple regression analysis, decreased body mass index (BMI) of ≥ 5% influenced fat persistence less than muscle persistence at POY1; however, there was no significant difference at POY5. Postoperative radiation therapy was associated with a significant decrease in total flap persistence at POY1 (p = 0.046) and POY5 (p = 0.0097). Muscle persistence significantly decreased at POY5 (p = 0.0108). Age significantly influenced muscle volume at POY1 (p = 0.0072). CONCLUSION:  Reconstruction flaps are well-preserved with high fat-to-muscle ratios. Recommendations for weight maintenance are necessary for patients less than 2 years after surgery due to the influence of BMI on fat persistence. Radiation therapy is necessary for some patients based on their disease state. Intensity-modulated radiation therapy can be offered to reduce scattering irradiation to normal tissues.
    2019年05月, Journal of reconstructive microsurgery, 35(4) (4), 235 - 243, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yumi Muraki, Takumi Hasegawa, Daisuke Takeda, Takeshi Ueha, Eiji Iwata, Izumi Saito, Rika Amano, Akiko Sakakibara, Masaya Akashi, Takahide Komori
    BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis. MATERIALS AND METHODS: iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated. RESULTS: No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients. CONCLUSION: In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.
    2019年03月, Anticancer research, 39(3) (3), 1205 - 1216, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Nagisa Nanba, Junya Kusumoto, Takahide Komori
    In brief, perioperative oral intervention consists of elimination of odontogenic foci and maintenance of oral hygiene in patients undergoing surgery. The importance of oral intervention before, during, and after medical treatments is well-known, especially in cancer patients, because odontogenic foci such as untreated deep dental caries or periodontitis can cause systemic infection in patients with myelosuppression resulting from chemotherapy. Although perioperative oral intervention is currently recommended for patients with cardiovascular disease, its efficacy in this population has not been established. This article consists of three sections: first, we review the current knowledge about the association between dental disease and cardiovascular disease to show the importance of oral hygiene maintenance and the risks of invasive dental procedures in patients with cardiovascular disease; second, we introduce pertinent, but limited evidence concerning the effect of oral care in preventing postoperative pneumonia; and finally, we present the optimal strategy for perioperative oral intervention in cardiovascular surgery patients.
    2019年02月, General thoracic and cardiovascular surgery, 67(2) (2), 197 - 202, 英語, 国内誌
    [査読有り][招待有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori
    PURPOSE: Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery. METHODS: A literature search was conducted using the MEDLINE database via PubMed. RESULTS: The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2-6 weeks postoperatively). CONCLUSIONS: Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.
    2018年12月, Oral and maxillofacial surgery, 22(4) (4), 369 - 378, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Satomi Arimoto, Takumi Hasegawa, Daisuke Takeda, Izumi Saito, Rika Amano, Masaya Akashi, Takahide Komori
    BACKGROUND/AIM: Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS: Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS: The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION: Podoplanin and LYVE-1 were strongly associated with LN metastasis.
    2018年11月, Anticancer research, 38(11) (11), 6157 - 6162, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Shun Teraoka, Yasumasa Kakei, Masaya Akashi, Eiji Iwata, Takumi Hasegawa, Daisuke Miyawaki, Ryohei Sasaki, Takahide Komori
    Enhancing the antitumor effect of radiation, while reducing damage to organs, is a significant challenge in radiation therapy for head and neck malignancies. One promising radiosensitizer is gold. The present study aimed to determine whether gold nanoparticles (AuNPs) have the potential to enhance the effects of X-ray irradiation on head and neck cancer cells. The human head and neck carcinoma cell line HSC-3 was used. Total cell number and the levels of cell proliferation and apoptosis were compared between control cells and cells treated with 5-nm AuNPs alone at four concentrations (0.1, 0.4, 1.0 and 10.0 nM), X-ray irradiation alone at three doses (2, 4 and 8 Gy), or a combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs. Analysis of variance and Tukey-Kramer testing were performed to compare the different groups. The total number of cells significantly decreased following 4 and 8 Gy X-ray irradiation, compared with in the control group (control vs. 4Gy, P=2.19×10-4; control vs. 8Gy, P=1.28×10-6). The combination of 4 Gy X-ray irradiation and 1.0 nM AuNPs significantly reduced the total number of cells compared with 4 Gy X-ray irradiation alone (P=2.95×10-4). Cell proliferation was not affected by AuNP treatment alone, 4 Gy X-ray irradiation alone or the combination of X-ray irradiation and AuNPs. The combination of 4 Gy irradiation and 1.0 nM AuNPs significantly increased the number of apoptotic cells compared with 4 Gy irradiation alone (P=0.0261). In conclusion, AuNPs combined with X-ray irradiation enhanced the cytotoxic effect on human head and neck cancer cells in vitro, through the induction of apoptosis, but not inhibition of cell proliferation.
    2018年11月, Biomedical reports, 9(5) (5), 415 - 420, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Izumi Saito, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Shunsuke Sakakibara, Yoshitada Sakai, Hiroto Terashi, Takahide Komori
    INTRODUCTION: Skin flap procedures are widely used to reconstruct skin and soft tissue defects. Skin flap necrosis is a serious postoperative complication. Many researchers have introduced pharmacological agents to improve flap ischemia in experimental studies. However, outcomes of these studies remain controversial. We previously demonstrated that transcutaneous CO2 application improves hypoxia in fracture repair. In this study, we hypothesized that improving hypoxia by transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis. We investigated whether transcutaneous CO2 application can increase the survival of random-pattern skin flaps. MATERIALS AND METHODS: Six-week-old male Sprague-Dawley rats were divided into two equal groups: the control group (n = 6) and CO2 group (n = 6). A random-pattern skin flap was constructed in these rats. Topical CO2 was applied using a hydrogel every day for 5 days in the CO2 group. The flap survival area was measured on postoperative days 1, 3, and 5. The vessel density and expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and hypoxia-inducible factor-1α (HIF-1α) were evaluated on postoperative day 5. RESULTS: A statistically significant difference was found in the percentage of the flap survival area between the two groups on postoperative days 3 and 5 (p < 0.05). Furthermore, the expression of VEGF and bFGF was significantly higher and that of HIF-1α was significantly lower in the CO2 than in the control group (p < 0.05). CONCLUSIONS: Transcutaneous CO2 application can improve the blood flow in skin flaps and increase angiogenesis, thus increasing the survival of random-pattern skin flaps.
    2018年11月, Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 71(11) (11), 1644 - 1651, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Kimikazu Yakushijin, Hiroshi Matsuoka, Takahide Komori
    PURPOSE: The purpose of this study was to measure the frequency and identify factors associated with delayed socket healing after dental extraction in patients undergoing myelosuppressive chemotherapy for hematologic malignancy. MATERIALS AND METHODS: This prospective cohort study focused on delayed healing after extraction in patients with hematologic malignancy. Sockets with delayed healing were defined as those with intense pain and bone exposure 1 week postoperatively. Patients with and without delayed socket healing were compared using the Fisher exact test and Mann-Whitney U test with some variables. Receiver operating characteristics curve analysis was conducted to define cutoff values for delayed healing. RESULTS: One hundred ninety-four dental extractions in 93 patients (median age, 64 yr; range, 20 to 85 yr) were analyzed. The incidence of delayed socket healing was 7.5% (7 of 93 patients). There was no postoperative bleeding. Older age, type of hematologic malignancy (acute leukemia), shorter time from dental extraction to initiation of chemotherapy, low platelet count or hemoglobin level, requirement for red blood cell concentrate or platelet transfusion, and use of an absorbable hemostatic agent were statistically associated with the occurrence of delayed socket healing. Platelet and hemoglobin cutoffs were 4.6 × 104/μL and 7.7 g/dL, respectively. CONCLUSIONS: Although dental extraction can be safely performed in patients undergoing myelosuppressive chemotherapy for hematologic malignancy, oral surgeons should understand the potential risk for delayed socket healing. When considering dental extraction, patients with hematologic malignancy and low hemoglobin or platelet levels should be informed about the possibility of delayed socket healing.
    2018年10月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76(10) (10), 2057 - 2065, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori
    Mosby Inc., 2018年09月, Oral surgery, oral medicine, oral pathology and oral radiology, 126(3) (3), 264 - 271, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Megumi Kishimoto, Masaya Akashi, Yasumasa Kakei, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Shungo Furudoi, Ryohei Sasaki, Takahide Komori
    BACKGROUND: A problematic complication after radiation therapy is lymphedema. Development of lymphedema is associated with an increase in lymphatic paracellular permeability. The current study investigated the effects of radiation on intercellular junctions and paracellular permeability in cultured human dermal lymphatic endothelial cells (HDLECs). METHODS AND RESULTS: Double immunofluorescence staining with vascular endothelial (VE)-cadherin and actin immediately after X-ray irradiation (5 or 20 Gy) was performed. Morphological changes induced by irradiation were assessed. Cell viability and paracellular permeability after irradiation were also evaluated. Broad junctions in which VE-cadherin was accumulated at cell-cell contacts and almost colocalized with actin were significantly decreased in a dose-dependent manner in confluent and sparse irradiated HDLECs. Irradiation shortened the width of VE-cadherin-positive areas at the cell-cell contacts. Actin filaments did not colocalize with VE-cadherin after 20 Gy irradiation. Although cell viability was not affected by irradiation, paracellular permeability significantly increased in a dose-dependent manner. CONCLUSIONS: A dose of 5 or 20 Gy irradiation in HDLECs does not affect cell viability, but changes VE-cadherin mediated intercellular junctions and actin structure, resulting in an increase of paracellular permeability. Further investigations on the regulatory proteins involved in radiation-induced changes, which were observed in the current study, may contribute to development of lymphedema therapy.
    2018年08月, Lymphatic research and biology, 16(4) (4), 390 - 396, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T. Hasegawa, S. I. Yamada, N. Ueda, S. Soutome, M. Funahara, M. Akashi, S. Furuno, H. Miyamoto, S. Hayashida, R. Amano, K. Mori, Y. Kojima, H. Kurita, T. Kirita, M. Umeda, Y. Shibuya, S. Fujita, T. Komori, Japanese Study Group of Cooperative Dentistry with Medicine (JCDM)
    Churchill Livingstone, 2018年06月, International Journal of Oral and Maxillofacial Surgery, 47(6) (6), 794 - 801, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 血管柄付遊離皮弁を用いた口腔癌の術後感染に関わる因子の検討
    梶 真人, 古土井 春吾, 岸本 恵美, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2018年06月, 日本口腔感染症学会雑誌, 25(1) (1), 14 - 19, 日本語
    [査読有り]

  • Michinori Maeda, Marina Hirose, Keinoshin Wada, Megumi Kishimoto, Masaya Akashi, Akira Kimoto, Takahide Komori, Yasuyuki Shibuya
    Elsevier Ltd, 2018年05月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 30(3) (3), 220 - 224, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Shun Teraoka, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Tsutomu Minamikawa, Kazunobu Hashikawa, Takahide Komori
    BACKGROUND: This study aimed to evaluate posttreatment soft-tissue changes in patients with oral cancer with computed tomography (CT). To accomplish that purpose, a scoring system was established, referring to the criteria of lower leg lymphedema (LE). METHODS AND RESULTS: One hundred and six necks in 95 patients who underwent oral oncologic surgery with neck dissection (ND) were analyzed retrospectively using routine follow-up CT images. A two-point scoring system to evaluate soft-tissue changes (so-called "LE score") was established as follows: Necks with a "honeycombing" appearance were assigned 1 point. Necks with "taller than wide" fat lobules were assigned 1 point. Necks with neither appearance were assigned 0 points. Comparisons between patients with LE score ≥1 and LE score = 0 at 6 months postoperatively were performed using the Fisher exact test for discrete variables and the Mann-Whitney U test for continuous variables. Univariate predictors associated with posttreatment changes (i.e., LE score ≥1 at 6 months postoperatively) were entered into a multivariate logistic regression analysis. Values of p < 0.05 were considered to indicate statistical significance. The occurrence of the posttreatment soft-tissue changes was 32%. Multivariate logistic regression analysis showed that postoperative radiation therapy (RT) and bilateral ND were potential risk factors of posttreatment soft-tissue changes on CT images. CONCLUSIONS: Sequential evaluation of "honeycombing" and the "taller than wide" appearances on routine follow-up CT revealed the persistence of posttreatment soft-tissue changes in patients who underwent oral cancer treatment, and those potential risk factors were postoperative RT and bilateral ND.
    2018年04月, Lymphatic research and biology, 16(2) (2), 147 - 153, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 榎本 由依, 明石 昌也, 平岡 佑二郎, 重岡 学, 南川 勉, 古森 孝英
    (公社)日本口腔外科学会, 2018年04月, 日本口腔外科学会雑誌, 64(4) (4), 213 - 218, 日本語
    [査読有り]

  • Masaya Akashi, Satoshi Wanifuchi, Eiji Iwata, Daisuke Takeda, Junya Kusumoto, Shungo Furudoi, Takahide Komori
    PURPOSE: The appearance of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) is similar, but clinically important differences between ORN and MRONJ exist. The aim of this study was to compare the clinical data between ORN and MRONJ and to reveal the critical differences between these diseases. METHODS: We retrospectively reviewed the epidemiological data, clinical findings, and treatment in 27 ORN and 61 MRONJ patients. Radiographic signs before the initiation of treatment were also assessed. RESULTS: The median age (P = 0.0474) and the ratio of female to male patients (P < 0.0001) were significantly higher in MRONJ patients. There were significantly more MRONJ patients who reported a history of pain when compared with ORN patients (P = 0.0263). As an aetiological factor, tooth extraction was significantly more relevant to MRONJ than ORN (P = 0.0352). When assessing the radiographic signs on computed tomographic images, periosteal reaction was found only in MRONJ patients (P = 0.0158). Minimal debridement was performed significantly more frequently for MRONJ (P = 0.0093), and by contrast, surgical resection was performed more frequently for ORN (P = 0.0002). CONCLUSIONS: Understanding the clinical and underlying pathological differences between ORN and MRONJ probably contributes to the selection of appropriate treatment for each patient.
    2018年03月, Oral and maxillofacial surgery, 22(1) (1), 59 - 63, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 岩田 英治, 古土井 春吾, 鰐渕 聡, 岸本 恵実, 明石 昌也, 古森 孝英
    (公社)日本口腔外科学会, 2018年02月, 日本口腔外科学会雑誌, 64(2) (2), 83 - 87, 日本語
    [査読有り]

  • Masaya Akashi, Takumi Hasegawa, Satoru Takahashi, Takahide Komori
    W.B. Saunders, 2018年02月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 76(2) (2), 304 - 313, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yumi Ohtsuki, Masaya Akashi, Kazunobu Hashikawa, Takahide Komori
    Elsevier Ltd, 2018年, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Megumi Kishimoto, Yasumasa Kakei, Kazunobu Hashikawa, Takahide Komori
    It was hypothesized that fluorodeoxyglucose (FDG) uptake on post-treatment follow-up positron emission tomography with computed tomography (PET CT; using PET CT to monitor and rule out recurrence and metastasis of head and neck carcinoma) would be useful for detecting and understanding the disease state of osteoradionecrosis (ORN) of the jaw. The present study included 14 patients who developed mandibular ORN following radiation therapy (RT) for head and neck cancer and underwent follow-up PET CT several times following RT. Areas exhibiting FDG uptake were retrospectively assessed on post-treatment follow-up PET CT images and were classified into three types: Spot type: Only spot accumulation of FDG; localized type: Accumulation of FDG restricted to within the bone resorption area; extensive type: Accumulation of FDG extending into surrounding soft tissue. PET classification at the time of clinical diagnosis of mandibular ORN in the 14 patients demonstrated the extensive type in 43%, localized type in 36% and spot type in 21%. An increased area of FDG uptake around the ORN was revealed retrospectively on post-treatment follow-up FDG PET-CT images in 50% of patients. Alterations in PET classification included spot type to localized type in 36% and localized type to extensive type in 14%. A significantly increased number of patients with extensive-type ORN (P=0.026) required surgery. Post-treatment follow-up FDG-PET CT may be useful for early detection and better understanding of ORN.
    2018年01月, Molecular and clinical oncology, 8(1) (1), 61 - 67, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • A Case Series of Fibro-Osseous Lesions of the Jaws.
    Masaya Akashi, Kenji Matsuo, Manabu Shigeoka, Yasumasa Kakei, Takumi Hasegawa, Akira Tachibana, Shungo Furudoi, Takahide Komori
    The aim of this case series was to reveal the difficulties in diagnosing fibro-osseous lesions with radiological and histopathological examinations and quantify the potential risk of infection to fibro-osseous legions. To analyze the concordance between radiological and histopathological diagnoses, this retrospective case series included patients who were clinically diagnosed with fibro-osseous lesions via radiological findings and excluded the patients who did not undergo histopathological examinations. This study also included the patients in whom histopathological results confirmed fibro-osseous legions when preoperative radiological diagnosis did not include fibro-osseous legions. Eleven patients (three men, eight women; median age 24.5 years, range 15-57 years) were enrolled. Although radiological diagnoses of fibrous dysplasia (FD) corresponded with histopathological diagnoses in seven patients, mismatches between radiological findings and histopathological results were found in three patients. In one patient, suspected diagnosis with radiological examinations was malignant lymphoma or FD. In two patients, the histopathological differentiation between FD and ossifying fibroma (OF) was difficult. One patient had lesion recurrence which was suspected to be OF with surgical findings and postoperative course after the initial surgery. In three patients, infections of FD were found. Preoperative diagnosis of OF with radiographic feature of unilocular radiolucency is difficult. In cases in which histopathological differentiation between FD and OF is difficult, operative findings should be used because OF is often found to be well-encapsulated and easily enucleated. Bone in FD showing mixed radiolucent-radiopaque may be vulnerable to infection.
    2017年12月, The Kobe journal of medical sciences, 63(3) (3), E73-E79 - 79, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yasumasa Kakei, Masaya Akashi, Masahiko Kashin, Sayaka Komori, Takahide Komori
    Elsevier Ltd, 2017年11月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(6) (6), 518 - 521, 英語
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori
    2017年11月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45(11) (11), 1778 - 1783, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masaya Akashi, Junya Kusumoto, Akiko Sakakibara, Kazunobu Hashikawa, Shungo Furudoi, Takahide Komori
    2017年10月, Surgical infections, 18(7) (7), 755 - 764, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tetsuya Hara, Tomoko Monguchi, Noriko Iwamoto, Masaya Akashi, Kenta Mori, Toshihiko Oshita, Mitsumasa Okano, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Yui Yamashita, Go Shioi, Mikio Furuse, Tatsuro Ishida, Ken-Ichi Hirata
    2017年09月, Arteriosclerosis, thrombosis, and vascular biology, 37(9) (9), 1667 - 1673, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 明石 昌也, 鰐渕 聡, 岩田 英治, 筧 康正, 長谷川 巧実, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2017年08月, Japanese Journal of Maxillo Facial Implants, 16(2) (2), 75 - 80, 日本語
    [査読有り]

  • Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori
    2017年08月, Experimental and therapeutic medicine, 14(2) (2), 953 - 960, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 頭頸部癌患者における化学放射線療法による口腔粘膜炎の重症度を予測する因子
    岸本 恵実, 古土井 春吾, 岩田 英治, 藤林 淳子, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24(1) (1), 9 - 13, 日本語
    [査読有り]

  • Izumi Saito, Takumi Hasegawa, Eiji Iwata, Natsuki Yonezawa, Satomi Arimoto, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori
    Elsevier Ltd, 2017年05月, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 29(3) (3), 217 - 221, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 肺癌術後肺合併症と周術期口腔機能管理の有用性
    岩田 英治, 長谷川 巧実, 西井 美佳, 明石 昌也, 古森 孝英
    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11(3) (3), 170 - 170, 日本語
    [査読有り]

  • Masaya Akashi, Kazuhiro Tanaka, Junya Kusumoto, Shungo Furudoi, Kohkichi Hosoda, Takahide Komori
    INTRODUCTION: Odontogenic foci can rarely cause intracranial infection. Hematogenous spread is considered to be the most important pathophysiological mechanism of intracranial infection of odontogenic origin. To investigate the oral origin of intracranial infections, oral surgeons should understand the underlying mechanisms by which oral bacteria spread to the central nervous system. However, there have been very few reports of intracranial infection resulting from odontogenic infection. CASE REPORTS: The authors report the cases of a 64-year-old man, a 68-year-old man, and a 64-year-old woman whose brain abscesses perhaps have arisen from odontogenic foci, because other sources of intracranial infection such as endocarditis and maxillary sinusitis were not found. Bacteriological examination of brain abscess specimens identified Staphylococcus aureus in case 1, Streptococcus constellatus, Fusobacterium nucleatum, and Parvimonas micra in case 2, and Lactobacillus catenaformis, Porphyromonas gingivalis, and F. nucleatum in case 3. All suspected causal teeth had no obvious signs of acute inflammation in all three cases. CONCLUSIONS: Oral surgeons should understand these characteristics of odontogenic brain abscess, in which the potentially causal odontogenic foci often lack acute symptoms. If other origins of infection are not found, it would be better to eliminate the potentially causal odontogenic foci for improvement of oral hygiene, however, the decision making criteria to eliminate suspected causal teeth is needed to be elucidated.
    2017年03月, Journal of maxillofacial and oral surgery, 16(1) (1), 58 - 64, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Meaning and Limitation of Cortical Bone Width Measurement with DentaScan in Medication-Related Osteonecrosis of the Jaws.
    Eiji Iwata, Masaya Akashi, Megumi Kishimoto, Junya Kusumoto, Takumi Hasegawa, Shungo Furudoi, Takahide Komori
    Kobe University School of Medicine, 2017年02月, The Kobe journal of medical sciences, 62(5) (5), E114-E119 - E119, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T. Hasegawa, S. Kawabata, D. Takeda, E. Iwata, I. Saito, S. Arimoto, A. Kimoto, M. Akashi, H. Suzuki, T. Komori
    Churchill Livingstone, 2017年02月, International Journal of Oral and Maxillofacial Surgery, 46(2) (2), 267 - 273, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori
    2017年, PloS one, 12(1) (1), e0169723, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori
    2017年01月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 45(1) (1), 145 - 149, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Megumi Kishimoto, Masaya Akashi, Kazuyuki Tsuji, Junya Kusumoto, Shungo Furudoi, Yasuyuki Shibuya, Yumiko Inui, Kimikazu Yakushijin, Shinichiro Kawamoto, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori
    2017年, PloS one, 12(7) (7), e0182021, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori
    2017年, BioMed research international, 2017, 3125842 - 3125842, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 高齢者の外傷歯に関する臨床的検討
    古土井 春吾, 可信 雅彦, 筧 康正, 松本 耕祐, 明石 昌也, 古森 孝英
    (一社)日本外傷歯学会, 2016年12月, 日本外傷歯学会雑誌, 12(1) (1), 53 - 59, 日本語

  • Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction.
    Satoshi Wanifuchi, Masaya Akashi, Yasuo Ejima, Hirotaka Shinomiya, Tsutomu Minamikawa, Shungo Furudoi, Naoki Otsuki, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
    PURPOSE: This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. METHODS: A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of ORN, relationship between tooth extraction and ORN occurrence, and time interval between tooth extraction and the initiation or end of RT. RESULTS: Twenty-one percent of ORN cases resulted from tooth extraction. The most common site of ORN (82 %) was the mandibular molar region. About half of ORN cases (49 %) occurred within 2 years after RT. All patients who received tooth extraction after RT developed ORN (100 %) independently of time interval between tooth extraction and the end of RT (median interval, 37.5 months; range, 27-120 months). In contrast, only 50 % of patients who received tooth extraction before RT developed ORN. There may have been an association between the irradiation field and the site of ORN development CONCLUSIONS: ORN occurrence due to tooth extraction was 21 %. Occurrence timing of ORN did not depend on time interval between tooth extraction and the end of RT. The irradiation field is certainly related to the site of ORN; therefore, prophylactic tooth extraction should be performed in consideration of the proposed radiation field and dose.
    2016年12月, Oral and maxillofacial surgery, 20(4) (4), 337 - 342, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori
    2016年10月, Implant dentistry, 25(5) (5), 715 - 9, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori
    Springer Verlag, 2016年09月, Oral and maxillofacial surgery, 20(3) (3), 233 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori
    2016年05月, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 44(5) (5), 637 - 41, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • 高端 大希, 明石 昌也, 高橋 佑輔, 辻 和志, 南川 勉, 古森 孝英
    (公社)日本口腔外科学会, 2016年04月, 日本口腔外科学会雑誌, 62(4) (4), 163 - 168, 日本語
    [査読有り]

  • A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy
    AkashiM, ShibuyaY, TakahashiY, KusumotoJ, SakakibaraA, HasegawaT, MinamikawaT, HashikawaK, KomoriT
    2016年, J Oral Maxillofac Surg Med Pathol, 28(2) (2), 111 - 117, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Tsutomu Minamikawa, Satoshi Usami, Takahide Komori
    2016年01月, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 74(1) (1), 212 - 7, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Yujiro Hiraoka, Takumi Hasegawa, Takahide Komori
    Bentham Science Publishers B.V., 2016年, The open dentistry journal, 10, 728 - 732, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • ロケーター・磁性バーアタッチメントによるインプラントオーバーデンチャー関連合併症
    有本 智美, 長谷川 巧実, 斉藤 泉, 岩田 英治, 武田 大介, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2015年11月, Japanese Journal of Maxillo Facial Implants, 14(3) (3), 261 - 261, 日本語

  • 岩田 英治, 明石 昌也, 後藤 育子, 古土井 春吾, 古森 孝英
    (一社)日本口腔診断学会, 2015年10月, 日本口腔診断学会雑誌, 28(3) (3), 208 - 212, 日本語
    [査読有り]

  • 楠元 順哉, 古土井 春吾, 榊原 晶子, 畑 みどり, 明石 昌也, 古森 孝英
    (公社)日本口腔外科学会, 2015年10月, 日本口腔外科学会雑誌, 61(10) (10), 505 - 512, 日本語
    [査読有り]

  • Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori
    2015年10月, IMPLANT DENTISTRY, 24(5) (5), 541 - 546, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takumi Hasegawa, Izumi Saito, Daisuke Takeda, Eiji Iwata, Natsuki Yonezawa, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori
    2015年09月, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 43(7) (7), 1094 - 1098, 英語
    [査読有り]
    研究論文（学術雑誌）

  • M. Akashi, K. Hashikawa, Y. Kakei, A. Sakakibara, T. Hasegawa, T. Minamikawa, T. Komori
    2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 942 - 947, 英語
    [査読有り]
    研究論文（学術雑誌）

  • S. Arimoto, T. Hasegawa, N. Okamoto, A. Shioyasono, C. Tateishi, M. Akashi, H. Suzuki, S. Furudoi, T. Komori
    2015年08月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(8) (8), 977 - 983, 英語
    [査読有り]
    研究論文（学術雑誌）

  • W. Huang, T. Hasegawa, Y. Imai, D. Takeda, M. Akashi, T. Komori
    2015年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(7) (7), 929 - 935, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉
    (一社)日本形成外科学会, 2015年06月, 日本形成外科学会会誌, 35(6) (6), 359 - 359, 日本語

  • Takumi Hasegawa, Makiko Tanakura, Daisuke Takeda, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori
    2015年06月, OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 152(6) (6), 1053 - 1060, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shunsuke Sakakibara, Hiroyuki Onishi, Kazunobu Hashikawa, Masaya Akashi, Akiko Sakakibara, Tadashi Nomura, Hiroto Terashi
    2015年05月, JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 31(4) (4), 305 - 312, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori
    2015年05月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 73(5) (5), 1003 - 1007, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 頸部郭清術後に中毒性巨大結腸症を併発した偽膜性腸炎を発症した1例
    岩田 英治, 古土井 春吾, 楠元 順哉, 明石 昌也, 後藤 育子, 古森 孝英
    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22(1) (1), 12 - 16, 日本語
    [査読有り]

  • 当院における心臓血管外科患者に対する周術期口腔機能管理
    藤 大補, 明石 昌也, 古土井 春吾, 西井 美佳, 後藤 育子, 古森 孝英
    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22(1) (1), 37 - 37, 日本語

  • 抗RANKLモノクローナル抗体(デノスマブ)投与患者に発症した顎骨壊死の1例
    岩田 英治, 明石 昌也, 長谷川 巧実, 古土井 春吾, 古森 孝英
    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22(1) (1), 41 - 42, 日本語

  • Masaya Akashi, Shungo Furudoi, Kazunobu Hashikawa, Akiko Sakakibara, Takumi Hasegawa, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori
    2015年04月, JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 44, 13, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T. Hasegawa, C. Tateishi, M. Asai, Y. Imai, N. Okamoto, A. Shioyasono, A. Kimoto, M. Akashi, H. Suzuki, S. Furudoi, T. Komori
    2015年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 349 - 355, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 重田 崇至, 南川 勉, 明石 昌也, 長谷川 巧実, 榊原 晶子, 松井 太輝, 筧 康正, 高橋 佑輔, 渋谷 恭之, 梅田 正博, 古森 孝英
    (一社)日本口腔腫瘍学会, 2015年03月, 日本口腔腫瘍学会誌, 27(1) (1), 1 - 6, 日本語
    [査読有り]

  • Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, T. Komori
    2015年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 44(3) (3), 412 - 416, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Clinical Study of 19 Cases Resulting in Dental Implant Removal.
    Hiroaki Suzuki, Daiki Takahashi, Kenji Matsuo, Akira Kimoto, Kousuke Matsumoto, Takumi Hasegawa, Masaya Akashi, Takahide Komori
    Kobe University School of Medicine, 2015年02月, The Kobe journal of medical sciences, 61(4) (4), E102-8 - E108, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • K. Tsuji, Y. Shibuya, M. Akashi, S. Furudoi, K. Yakushijin, S. Kawamoto, A. Okamura, H. Matsuoka, T. Komori
    2015年02月, JOURNAL OF DENTAL RESEARCH, 94(2) (2), 289 - 296, 英語
    研究論文（学術雑誌）

  • Masaya Akashi, Kazunobu Hashikawa, Akiko Sakakibara, Takahide Komori, Hiroto Terashi
    2015年01月, JOURNAL OF CRANIOFACIAL SURGERY, 26(1) (1), 48 - 51, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Spindle cell carcinoma of the oral cavity: The impact of chemotherapy on pulmonary metastatic tumor doubling time
    Takashi Shigeta, Tsutomu Minamikawa, Taiki Matsui, Yasumasa Kakei, Masaya Akashi, Takumi Hasegawa, Akiko Sakakibara, Yasuyuki Shibuya, Takahide Komori
    Kobe University School of Medicine, 2015年, Kobe Journal of Medical Sciences, 61(3) (3), E64 - E70, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Measurement of the Total Number of Bacteria in Saliva Using Quantitative Real-Time PCR During Treatment for Head and Neck Malignancy: A Series of Cases
    GotoI, FurudoiS, AkashiM, KomoriT
    2015年, Oral Health Dent Manag, 142(776) (776), 英語
    [査読有り]
    研究論文（学術雑誌）

  • Evaluation and comparison of CT values in bisphosphonate-related osteonecrosis of the jaw
    ImaiY, HasegawaT, TakedaD, KusumotoJ, AkashiM, LeeSY, FurudoiS, KomoriT
    2015年, J Oral Maxillofac Surg Med Pathol, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasumasa Kakei, Masaya Akashi, Takashi Shigeta, Takumi Hasegawa, Takahide Komori
    2014年09月, LYMPHATIC RESEARCH AND BIOLOGY, 12(3) (3), 136 - 143, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study
    Nishii M, Akashi M, Kakei Y, Hasegawa T, Minamikawa T, Furudoi S, Shibuya Y, Takahashi M, Otsuki N, Nibu K, Komori T
    2014年06月, Oral Health Dent Manag, 13(2) (2), 507 - 11, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori
    2014年04月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(4) (4), 387 - 392, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori
    2014年03月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43(3) (3), 367 - 372, 英語
    [査読有り]
    研究論文（学術雑誌）

  • T. Hasegawa, C. Tateishi, M. Asano, N. Takata, M. Akashi, T. Shigeta, S. Furudoi, Y. Shibuya, T. Komori
    2013年11月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(11) (11), 1454 - 1461, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Tadashi Nomura, Shunsuke Sakakibara, Akiko Sakakibara, Kazunobu Hashikawa
    2013年09月, MICROSURGERY, 33(6) (6), 454 - 459, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Yasuyuki Shibuya, Junya Kusumoto, Shungo Furudoi, Yumiko Inui, Kimikazu Yakushijin, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori
    2013年08月, BMC Oral Health, 13(1) (1), 41, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • T. Hasegawa, S. Ri, T. Shigeta, M. Akashi, Y. Imai, Y. Kakei, Y. Shibuya, T. Komori
    2013年07月, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42(7) (7), 843 - 851, 英語
    [査読有り]
    研究論文（学術雑誌）

  • がん切除後下顎骨再建における再建理論「CATコンセプト」 臨床症例における実践結果
    橋川 和信, 明石 昌也, 野村 正, 寺師 浩人
    (一社)日本頭頸部癌学会, 2013年05月, 頭頸部癌, 39(2) (2), 166 - 166, 日本語
    [査読有り]

  • Tomoko Sugawara, Noriko Iwamoto, Masaya Akashi, Taro Kojima, Junzo Hisatsune, Motoyuki Sugai, Mikio Furuse
    2013年04月, JOURNAL OF DERMATOLOGICAL SCIENCE, 70(1) (1), 12 - 18, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasuyuki Shibuya, Takumi Hasegawa, Masaya Akashi, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori
    2013年04月, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71(4) (4), 793 - 797, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yasumasa Kakei, Masaya Akashi, Hideki Komatsubara, Tsutomu Minamikawa, Takahide Komori
    2012年06月, HEAD & NECK ONCOLOGY, 4, 38, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Masaya Akashi, Tomohito Higashi, Sayuri Masuda, Takahide Komori, Mikio Furuse
    2011年09月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 413(2) (2), 224 - 229, 英語
    研究論文（学術雑誌）

  • Ken Yoshihara, Junichi Ikenouchi, Yasushi Izumi, Masaya Akashi, Shoichiro Tsukita, Mikio Furuse
    2011年02月, EXPERIMENTAL CELL RESEARCH, 317(4) (4), 413 - 422, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sayuri Masuda, Yukako Oda, Hiroyuki Sasaki, Junichi Ikenouchi, Tomohito Higashi, Masaya Akashi, Eiichiro Nishi, Mikio Furuse
    2011年02月, JOURNAL OF CELL SCIENCE, 124(4) (4), 548 - 555, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 明石 昌也, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英
    (公社)日本口腔外科学会, 2008年03月, 日本口腔外科学会雑誌, 54(3) (3), 210 - 213, 日本語
    [査読有り]

  • A clinical study of temporomandibular joint disorders -An analysis based on the Japanese subtype classification
    Yasuyuki Shibuya, Junichiro Takeuchi, Noriko Ikehata, Masaya Akashi, Tsuyoshi Fujita, Satoshi Yokoo, Masahiro Umeda, Takahide Komori
    2007年, Kobe Journal of Medical Sciences, 53(2) (2), 63 - 70, 英語
    [査読有り]
    研究論文（学術雑誌）

  • 明石 昌也, 李 進彰, 石田 佳毅, 中川 直美, 柳川 由美恵, 古森 孝英
    (NPO)日本口腔科学会, 2007年01月, 日本口腔科学会雑誌, 56(1) (1), 189 - 190, 日本語

  • 梅田 正博, 李 進彰, 石田 佳毅, 中川 直美, 明石 昌也, 大川 修司, 西松 成器, 南川 勉, 古森 孝英
    (一社)日本口腔腫瘍学会, 2006年03月, 日本口腔腫瘍学会誌, 18(1) (1), 1 - 5, 日本語
    [査読有り]

■ MISC
  • 頭頸部腺様嚢胞癌に対する陽子線治療の初期成績
    瓜生 開人, 出水 祐介, 岩下 和真, 福光 延吉, 明石 昌也, 副島 俊典
    (一社)日本頭頸部癌学会, 2024年05月, 頭頸部癌, 50(2) (2), 190 - 190, 日本語

  • 口腔扁平上皮癌に対するニボルマブの治療効果と好中球数・リンパ球数比に関する研究
    立浪秀剛, 冨原圭, 山田慎一, 池田篤司, 今上修一, 中井裕美, 黒原一人, 吉岡幸男, 長谷川巧実, 鳴瀬智史, 新山宗, 嶋根哲, 上田倫弘, 柳本惣市, 明石昌也, 梅田正博, 栗田浩, 宮崎晃亘, 新井直也, 野口誠
    2023年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st

  • LBC/新報告様式を基軸とした顎口腔擦過細胞診:判定精度と病院歯科における位置付け
    佐々木亜紀, 重岡学, 重岡学, 米田亜紀子, 米田亜紀子, 武田大介, 明石昌也
    2023年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 41st

  • 頭頸部粘膜悪性黒色腫に対する陽子線治療+adjuvant Nivolumab療法
    瓜生開人, 出水祐介, 窪田光, 美馬正幸, 福光延吉, 今村善宣, 明石昌也, 副島俊典
    2023年, 頭頸部癌, 49(2) (2)

  • 嗅神経芽細胞腫に対する陽子線を用いた術後照射 神戸陽子線センターにおける初期治療成績
    瓜生 開人, 出水 祐介, 美馬 正幸, 福光 延吉, 明石 昌也, 副島 俊典
    (一社)日本頭頸部癌学会, 2022年05月, 頭頸部癌, 48(2) (2), 239 - 239, 日本語

  • 口腔癌の入院加療中に介護保険申請が必要となった患者の検討
    武田大介, 長谷川巧実, 筧康正, 明石昌也
    2022年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th

  • 多施設後ろ向き試験による舌癌における手術断端近接症例の検討-Japan Oral Oncology Group(JOOG) study-
    大鶴光信, 長谷川巧実, 明石昌也, 山川延宏, 桐田忠昭, 大倉正也, 大倉正也, 山田慎一, 栗田浩, 平井英治, 山本晃三, 猪俣徹, 里見貴史, 齋藤寛一, 野村武史, 古川浩平, 鳴瀬智史, 柳本惣市, 梅田正博
    2022年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 40th

  • Satomi Arimoto, Manabu Shigeoka, Masaya Akashi
    Hindawi Limited, 2021年, Case Reports in Dentistry, 2021, 英語
    書評論文,書評,文献紹介等

  • 炭酸ガス経皮投与による腫瘍免疫抑制の改善効果
    八谷奈苗, 長谷川巧実, 武田大介, 齊藤泉, 有本智美, 筧康正, 榊原晶子, 明石昌也
    2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th

  • 病理組織学的にリンパ上皮癌と診断された舌癌の1例
    武田大介, 重岡学, 長谷川真子, 村上明希, 八谷奈苗, 長谷川巧実, 明石昌也
    2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th

  • 口腔癌における非制御症例の考察と今後の展望~大学病院での検討~
    長谷川巧実, 武田大介, 筧康正, 明石昌也
    2021年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 39th

  • 延原 浩, 五月女 さき子, 林田 咲, 梅田 正博, 長谷川 巧実, 明石 昌也, 山田 慎一, 栗田 浩, 中原 寛和, 上田 順宏, 桐田 忠昭, 中村 知寿, 渋谷 恭之, 山口 泰平, 森 和代
    (一社)日本外科感染症学会, 2020年10月, 日本外科感染症学会雑誌, 17(5) (5), 329 - 329, 日本語

  • 舌下神経麻痺を契機に発見された前立腺癌脳転移の1例
    佐々木 亜紀, 木本 明, 八谷 奈苗, 村上 明希, 明石 昌也
    (NPO)日本口腔科学会, 2020年09月, 日本口腔科学会雑誌, 69(3) (3), 245 - 245, 日本語

  • 舌に生じた腺扁平上皮癌の1例
    大堀 浩明, 筧 康正, 山下 淳也, 南川 勉, 明石 昌也
    (NPO)日本口腔科学会, 2020年09月, 日本口腔科学会雑誌, 69(3) (3), 248 - 248, 日本語

  • 顎骨壊死の病態機序解明
    明石 昌也
    (株)北隆館, 2020年07月, BIO Clinica, 35(7) (7), 680 - 683, 日本語

  • 頭頸部癌における免疫チェックポイント阻害薬後の救済化学療法についての後方視的検討
    小山 泰司, 清田 尚臣, 今村 善宣, 長谷 善明, 高倉 嗣丈, 蓼原 瞬, 入谷 啓介, 古川 竜也, 手島 直則, 四宮 弘隆, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一
    (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46(2) (2), 174 - 174, 日本語

  • 当院における頭頸部がんに対する高用量シスプラチン併用化学放射線療法による急性腎障害の後方視的検討
    高倉 嗣丈, 今村 善宣, 小山 泰司, 長谷 善明, 四宮 弘隆, 手島 直則, 古川 竜也, 入谷 啓介, 蓼原 瞬, 宮脇 大輔, 明石 昌也, 佐々木 良平, 丹生 健一, 清田 尚臣
    (一社)日本頭頸部癌学会, 2020年07月, 頭頸部癌, 46(2) (2), 185 - 185, 日本語

  • 嚢胞壁の一部に異所性胃粘膜を認めた甲状舌管嚢胞の1例
    小林 正樹, 森田 麻希, 中村 健人, 中村 知寿, 水谷 友美, 菱田 純代, 青木 尚史, 加藤 伸一郎, 明石 昌也, 渋谷 恭之
    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 87 - 87, 日本語

  • 原因検索に難渋した口底蜂窩織炎の1例
    岩田 英治, 橘 進彰, 格谷 僚, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也
    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 119 - 120, 日本語

  • 顎骨壊死を契機として切開排膿を要した咀嚼筋隙膿瘍の検討
    下間 祐輝, 武田 大介, 佐々木 亜紀, 小林 英里奈, 八橋 明子, 齋藤 泉, 楠元 順哉, 長谷川 巧実, 古土井 春吾, 明石 昌也
    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 121 - 121, 日本語

  • 当科で歯科介入を行った高用量骨吸収抑制薬使用患者におけるMRONJ発症とリスク因子についての検討
    廣田 純也, 長谷川 巧実, 武田 大介, 筧 康正, 楠元 順哉, 榊原 晶子, 木本 明, 明石 昌也
    (NPO)日本口腔科学会, 2020年07月, 日本口腔科学会雑誌, 69(2) (2), 153 - 153, 日本語

  • 神戸大学医学部付属病院歯科口腔外科における抗菌薬適正使用の現状
    吉位 亮助, 楠元 順哉, 松村 恵美, 古土井 春吾, 明石 昌也
    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27(1) (1), 36 - 37, 日本語

  • エピシル口腔用液による口腔粘膜炎の疼痛緩和についての検討
    松村 恵実, 西井 美佳, 楠元 順哉, 古土井 春吾, 明石 昌也
    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27(1) (1), 38 - 38, 日本語

  • 若年女性の頬部蜂窩織炎から肺化膿症にまで進展したMRSA菌血症の1例
    大橋 雄高, 南川 勉, 岩田 英治, 松村 恵美, 古土井 春吾, 明石 昌也
    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27(1) (1), 41 - 41, 日本語

  • 頬部の皮膚充填剤により生じた頬部蜂窩織炎の1例
    榎本 由依, 橘 進彰, 岩田 英治, 高田 直樹, 明石 昌也
    (一社)日本口腔感染症学会, 2020年07月, 日本口腔感染症学会雑誌, 27(1) (1), 44 - 44, 日本語

  • 症状の背景にあるもの
    明石 昌也
    (一社)兵庫県歯科医師会, 2020年06月, 歯界月報, (827) (827), 24 - 30, 日本語

  • 佐々木 崇良, 木本 明, 八谷 奈苗, 山下 淳也, 重岡 学, 明石 昌也
    (一社)日本レーザー歯学会, 2020年05月, 日本レーザー歯学会誌, 30(1) (1), 22 - 22, 日本語

  • アルツハイマー型認知症患者の口腔内に生じた孤立性形質細胞腫に対して放射線治療が奏功した1例
    棚倉万紀子, 武田大介, 三谷泉, 明石昌也
    2020年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th

  • 口腔外科手術周術期における抗血栓療法患者に対するヘパリンブリッジの有効性に関する多施設共同後ろ向き観察研究
    後藤弘一, 山田慎一, 長谷川巧実, 吉村仁志, 五月女さき子, 冨原圭, 長谷川温, 菱田純代, 上田順宏, 傳田祐也, 岡本健二郎, 明石昌也, 近津大地, 野口誠, 太田嘉英, 藤田茂之, 藤田茂之, 渋谷恭之, 桐田忠昭, 梅田正博, 栗田浩
    2020年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 38th

  • 大腸癌術後SSIに対する周術期口腔ケアの予防効果に関する多施設共同研究
    延原浩, 五月女さき子, 林田咲, 梅田正博, 長谷川巧実, 明石昌也, 山田慎一, 栗田浩, 中原寛和, 上田順宏, 桐田忠昭, 中村知寿, 渋谷恭之, 山口泰平, 森和代
    2020年, 日本外科感染症学会雑誌(Web), 17(5) (5)

  • 【「顎骨再建材料」】ポリ-L-乳酸
    明石 昌也
    (一社)日本歯科理工学会, 2020年01月, 日本歯科理工学会誌, 39(1) (1), 13 - 16, 日本語

  • 明日から役立つ!がん患者の口腔機能管理テクニック
    西井 美佳, 古土井 春吾, 松村 恵実, 楠元 順哉, 明石 昌也
    (一社)日本口腔感染症学会, 2020年01月, 日本口腔感染症学会雑誌, 26(2) (2), 68 - 73, 日本語

  • 岩田 英治, 橘 進彰, 高井 美玲, 榎本 由依, 楠元 順哉, 高田 直樹, 明石 昌也
    (一社)日本口腔腫瘍学会, 2019年12月, 日本口腔腫瘍学会誌, 31(4) (4), 203 - 206, 日本語

  • 重症心身障がい児(者)における口腔衛生状態の実態調査
    柴田 里紗, 明石 昌也, 小紫 香代, 玉村 宣尚
    国立病院総合医学会, 2019年11月, 国立病院総合医学会講演抄録集, 73回, P1 - 805, 日本語

  • 【「歯科用レーザーの現在」】軟組織に対する歯科用レーザーの活用
    木本 明, 明石 昌也, 古森 孝英
    (一社)日本歯科理工学会, 2019年09月, 日本歯科理工学会誌, 38(3) (3), 149 - 152, 日本語

  • 木本 明, 明石 昌也
    (NPO)日本レーザー医学会, 2019年09月, 日本レーザー医学会誌, 40(3) (3), 265 - 265, 日本語

  • 多剤耐性菌が検出された薬剤関連顎骨壊死患者の治療経験
    大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2019年06月, 日本口腔感染症学会雑誌, 26(1) (1), 43 - 43, 日本語

  • ゾレドロン酸の投与が奏効したび漫性硬化性下顎骨骨髄炎の1例
    佐藤 匠, 古土井 春吾, 大橋 雄高, 岸本 恵美, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2019年06月, 日本口腔感染症学会雑誌, 26(1) (1), 45 - 46, 日本語

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平
    (一社)日本頭頸部癌学会, 2019年05月, 頭頸部癌, 45(2) (2), 244 - 244, 日本語

  • 頭頸部癌に対する放射線治療後の放射線性顎骨壊死に関する検討
    窪田 光, 宮脇 大輔, 佐々木 香織, 妹尾 悟史, 井上 由子, 川口 弘毅, 西川 遼, 石原 武明, 吉田 賢史, 岸本 恵美, 明石 昌也, 佐々木 良平
    (一社)日本頭頸部癌学会, 2019年05月, 頭頸部癌, 45(2) (2), 244 - 244, 日本語

  • 口腔扁平上皮癌における人工多能性幹細胞関連因子の発現について
    武田大介, 長谷川巧実, 江崎友美, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th

  • 当科におけるUnusualな再発症例について
    筧康正, 南川勉, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 122, 日本語

  • 炭酸ガスを使用した効率的な低酸素環境改善による口腔癌の新規治療法の開発と治療抵抗性の改善効果
    長谷川巧実, 武田大介, 齋藤泉, 岩田英治, 筧康正, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 120, 日本語

  • 再建を伴う口腔癌の周術期静脈血栓塞栓症について
    筧康正, 明石昌也, 長谷川巧実, 南川勉, 古森孝英
    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 112, 日本語

  • 口腔癌におけるPET‐MRI~第二報~
    瓜生開人, 南川勉, 大橋雄高, 大橋雄高, 松田彩, 武田大介, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2019年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 37th, 156, 日本語

  • 古土井 春吾, 岩田 英治, 岸本 恵美, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2018年12月, 日本口腔感染症学会雑誌, 25(2) (2), 71 - 77, 日本語

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究
    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, 日本語

  • 当科におけるインプラント埋入症例と喪失リスク因子に関する後ろ向き観察研究
    長谷川 巧実, 武田 大介, 齋藤 泉, 有本 智美, 筧 康正, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2018年11月, Japanese Journal of Maxillo Facial Implants, 17(3) (3), 224 - 224, 日本語

  • Four-dimensional CT(4DCT)による咀嚼時の下顎頭前方滑走の解析
    関谷 俊範, 明石 昌也, 筧 康正, 根宜 典行, 西尾 卓郎, 星野 貴志, 櫻井 玲, 泉谷 信行, 日下 亜起子, 古森 孝英, 村上 卓道
    (公社)日本診療放射線技師会, 2018年09月, JART: 日本診療放射線技師会誌, 65(9) (9), 1011 - 1011, 日本語

  • 柴田 里紗, 明石 昌也, 玉村 宜尚
    日本重症心身障害学会, 2018年08月, 日本重症心身障害学会誌, 43(2) (2), 343 - 343, 日本語

  • 当院における過去10年間の外傷歯症例の臨床的検討 世代別の特徴に関する分析
    佐藤 匠, 古土井 春吾, 可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英
    (一社)日本外傷歯学会, 2018年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 18回, 48 - 48, 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討
    筧 康正, 南川 勉, 白井 達也, 大橋 雄高, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 103 - 103, 日本語

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討
    八谷 奈苗, 長谷川 巧実, 武田 大介, 筧 康正, 松井 太輝, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 117 - 117, 日本語

  • 膠原病を有する口腔癌症例の臨床的検討
    廣田 純也, 南川 勉, 松田 彩, 松井 太輝, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 121 - 121, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討
    松田 彩, 南川 勉, 白井 達也, 筧 康正, 松井 太輝, 長谷川 巧実, 榊原 晶子, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 112 - 112, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例
    香西 慎一, 松井 太輝, 筧 康正, 松田 彩, 明石 昌也, 長谷川 巧実, 南川 勉, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 113 - 113, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討
    大橋 雄高, 筧 康正, 松田 彩, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 110 - 110, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討
    白井 達也, 松井 太輝, 筧 康正, 大橋 雄高, 松田 彩, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英
    (NPO)日本口腔科学会, 2018年07月, 日本口腔科学会雑誌, 67(2) (2), 119 - 119, 日本語

  • 当科における過去10年間の血液培養検査に関する臨床的検討
    大橋 雄高, 古土井 春吾, 岸本 恵, 岩田 英治, 高橋 淳子, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2018年06月, 日本口腔感染症学会雑誌, 25(1) (1), 48 - 48, 日本語

  • 翼突下顎隙に及ぶ蜂窩織炎に付随した舌神経知覚鈍麻に対し星状神経節ブロックを施行した1例
    白井 達也, 明石 昌也, 岸本 恵実, 古森 孝英
    (NPO)日本口腔科学会, 2018年03月, 日本口腔科学会雑誌, 67(1) (1), 64 - 64, 日本語

  • 下顎智歯抜歯後の術後出血に関するリスク因子についての検討
    廣田純也, 長谷川巧実, 西條翔, 大山剛平, 武田大介, 明石昌也, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2)

  • 頸部郭清を伴う口腔癌術後合併症に関する臨床的検討
    八谷奈苗, 長谷川巧実, 武田大介, 筧康正, 松井太輝, 明石昌也, 南川勉, 古土井春吾, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 117(J‐STAGE), 日本語

  • 頸部リンパ節転移陽性口腔扁平上皮癌の予後因子におけるlymph node ratioの有用性に関する検討
    筧康正, 南川勉, 白井達也, 大橋雄高, 大橋雄高, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 103(J‐STAGE), 日本語

  • 膠原病を有する口腔癌症例の臨床的検討
    廣田純也, 南川勉, 松田彩, 松井太輝, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 121(J‐STAGE), 日本語

  • 放射線性下顎骨壊死の診断におけるfollow up PET‐CTの有用性
    鰐渕聡, 明石昌也, 平岡佑二郎, 武田大介, 筧康正, 松井太輝, 長谷川巧実, 南川勉, 古土井春吾, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 161, 日本語

  • 皮弁再建後の再発舌癌に対して救済手術を施行した2例
    大橋雄高, 松井太輝, 筧康正, 正井友里子, 松田彩, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 181, 日本語

  • 当科における口腔癌への緩和照射に関する臨床的検討
    松田彩, 南川勉, 白井達也, 筧康正, 松井太輝, 長谷川巧実, 榊原晶子, 明石昌也, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 112(J‐STAGE), 日本語

  • 超音波断層法による口腔癌頸部リンパ節転移の検討
    筧康正, 南川勉, 正井友里子, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 重田崇至, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 160, 日本語

  • 舌扁平上皮癌の原発巣再発例の検討
    松井太輝, 南川勉, 大橋雄高, 正井友里子, 松田彩, 筧康正, 長谷川巧実, 明石昌也, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 164, 日本語

  • 術後に気道閉塞を生じた口腔癌患者の3例
    香西慎一, 松井太輝, 筧康正, 松田彩, 明石昌也, 長谷川巧実, 南川勉, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 113(J‐STAGE), 日本語

  • 口腔癌術後病理minor risk症例の臨床的検討
    松田彩, 松井太輝, 正井友里子, 筧康正, 長谷川巧実, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 151, 日本語

  • 口腔癌術後に予定外に再度の全身麻酔による手術を要した症例の検討
    大橋雄高, 筧康正, 松田彩, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 110(J‐STAGE), 日本語

  • 口腔癌再建術後Recipient‐site infectionの定義に関する文献レビュー
    明石昌也, 筧康正, 武田大介, 松井太輝, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英
    2018年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 36th, 149, 日本語

  • 口腔癌原発巣手術における術中迅速診断の臨床的検討
    白井達也, 松井太輝, 筧康正, 大橋雄高, 大橋雄高, 松田彩, 長谷川巧実, 明石昌也, 南川勉, 古森孝英
    2018年, 日本口腔科学会雑誌(Web), 67(2) (2), 119(J‐STAGE), 日本語

  • 上顎部分切除後の顎義歯装着に関する皮弁再建・非再建群の比較
    可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英
    (一社)日本顎顔面補綴学会, 2017年12月, 顎顔面補綴, 40(2) (2), 55 - 55, 日本語

  • 移植腓骨へ埋入したインプラント体の周囲炎に対し炭酸ガスレーザーを適用した1例
    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 松本 耕佑, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2017年11月, Japanese Journal of Maxillo Facial Implants, 16(3) (3), 233 - 233, 日本語

  • CBCTを用いた実物大臓器立体モデル作製の基礎検討
    西尾 卓郎, 山本 慶彦, 福富 朗世, 宮本 昌宜, 香川 清澄, 根宜 典行, 日下 亜起子, 高橋 哲, 明石 昌也, 筧 康正
    (公社)日本診療放射線技師会, 2017年09月, JART: 日本診療放射線技師会誌, 64(9) (9), 1220 - 1220, 日本語

  • 後藤 佳代子, 柴田 里紗, 明石 昌也, 玉村 宣尚
    日本重症心身障害学会, 2017年08月, 日本重症心身障害学会誌, 42(2) (2), 257 - 257, 日本語

  • 顎口腔領域の重症感染症例の検討
    高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24(1) (1), 14 - 20, 日本語

  • スニチニブに関連して発症したと考えられる下顎骨壊死の1例
    岩田 英治, 古土井 春吾, 岸本 恵実, 藤林 淳子, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24(1) (1), 51 - 51, 日本語

  • 口腔癌術後に消化管穿孔を発症した1例
    高橋 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24(1) (1), 54 - 55, 日本語

  • 結節性硬化症患者に対する口腔衛生管理の現状 エベロリムスによる口内炎への対応
    西井 美佳, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2017年07月, 日本口腔感染症学会雑誌, 24(1) (1), 61 - 61, 日本語

  • 当院における顎骨骨髄炎外来の現状と役割
    岩田 英治, 古土井 春吾, 鰐渕 聡, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 192 - 192, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討
    松田 彩, 筧 康正, 正井 友里子, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 南川 勉, 古森 孝英
    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 113 - 113, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討
    正井 友里子, 南川 勉, 松田 彩, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, 日本語

  • 4DCTによる咀嚼時の下顎頭前方滑走の解析
    明石 昌也, 大槻 有美, 黄 文蘇, 筧 康正, 古森 孝英
    (一社)日本顎関節学会, 2017年07月, 日本顎関節学会雑誌, 29(Suppl.) (Suppl.), 92 - 92, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討
    筧 康正, 南川 勉, 正井 友里子, 松田 彩, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2017年07月, 日本口腔科学会雑誌, 66(2) (2), 114 - 114, 日本語

  • 両腋窩動脈狭窄症によりスティール症候群をきたし手指切断に至った透析患者の一例
    豊田 大祐, 加藤 敏輝, 芝田 圭佑, 齋藤 謙司, 花田 昌也, 明石 晋太郎
    (一社)日本透析医学会, 2017年05月, 日本透析医学会雑誌, 50(Suppl.1) (Suppl.1), 756 - 756, 日本語

  • CAT分類における下顎骨切除範囲別の咀嚼機能と口腔QOLの評価
    前田 道徳, 渋谷 恭之, 明石 昌也, 古森 孝英
    (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43(2) (2), 170 - 170, 日本語

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究
    明石 昌也, 楠元 順哉, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英
    (一社)日本頭頸部癌学会, 2017年05月, 頭頸部癌, 43(2) (2), 189 - 189, 日本語

  • 頭頸部癌化学放射線治療患者における口腔内細菌数と口腔粘膜水分量の解析
    西井 美佳, 筧 康正, 難波 渚, 澤田 麻衣子, 岩田 英治, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英
    (一社)日本口腔ケア学会, 2017年04月, 日本口腔ケア学会雑誌, 11(3) (3), 121 - 121, 日本語

  • チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例
    可信 雅彦, 明石 昌也, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2017年03月, 日本口腔科学会雑誌, 66(1) (1), 54 - 54, 日本語

  • 口腔癌放射線治療における新規併用療法の開発
    岩田英治, 長谷川巧実, 武田大介, 斎藤泉, 有本智美, 明石昌也, 南川勉, 古森孝英
    2017年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 35th

  • 神戸大学医学部附属病院における心臓血管外科患者に対する周術期口腔機能管理の現状
    藤 大補, 古土井 春吾, 明石 昌也, 西井 美佳, 古森 孝英
    (一社)日本口腔感染症学会, 2017年01月, 日本口腔感染症学会雑誌, 23(2) (2), 43 - 47, 日本語

  • 当科における予防的頸部郭清術に関する後ろ向き検討
    松田彩, 筧康正, 正井友里子, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 南川勉, 古森孝英
    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 181, 日本語

  • 口腔扁平上皮癌における術後早期(1年以内)の予後不良例に関する臨床的検討
    正井友里子, 南川勉, 松田彩, 米澤奈津季, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討
    筧康正, 南川勉, 正井友里子, 松田彩, 米澤奈津季, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2017年, 日本口腔科学会学術集会プログラム・抄録集, 71st, 183, 日本語

  • Risk factors associated with oroantral perforation during surgical removal of maxillary third molar teeth.
    Takumi Hasegawa, Akira Tachibana, Daisuke Takeda, Eiji Iwata, Satomi Arimoto, Akiko Sakakibara, Masaya Akashi, Takahide Komori
    PURPOSE: The relationship between radiographic findings and the occurrence of oroantral perforation is controversial. Few studies have quantitatively analyzed the risk factors contributing to oroantral perforation, and no study has reported multivariate analysis of the relationship(s) between these various factors. This retrospective study aims to fill this void. METHODS: Various risk factors for oroantral perforation during maxillary third molar extraction were investigated by univariate and multivariate analysis. The proximity of the roots to the maxillary sinus floor (root-sinus [RS] classification) was assessed using panoramic radiography and classified as types 1-5. The relationship between the maxillary second and third molars was classified according to a modified version of the Archer classification. The relative depth of the maxillary third molar in the bone was classified as class A-C, and its angulation relative to the long axis of the second molar was also recorded. RESULTS: Performance of an incision (OR 5.16), mesioangular tooth angulation (OR 6.05), and type 3 RS classification (i.e., significant superimposition of the roots of all posterior maxillary teeth with the sinus floor; OR 10.18) were all identified as risk factors with significant association to an outcome of oroantral perforation. CONCLUSION: To our knowledge, this is the first multivariate analysis of the risk factors for oroantral perforation during surgical extraction of the maxillary third molar. This RS classification may offer a new predictive parameter for estimating the risk of oroantral perforation.
    2016年12月, Oral and maxillofacial surgery, 20(4) (4), 369 - 375, 英語, 国際誌

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討
    片岡 侑嗣, 長谷川 巧実, 綿越 健太, 浅井 雅敏, 有本 智美, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 218 - 218, 日本語

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例
    山下 淳也, 鈴木 泰明, 筧 康正, 木本 明, 長谷川 巧実, 明石 昌也, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2016年11月, Japanese Journal of Maxillo Facial Implants, 15(3) (3), 207 - 207, 日本語

  • 放射線性顎骨壊死症例に対する画像診断を中心とした臨床的検討
    鰐渕 聡, 明石 昌也, 岩田 英治, 楠元 順哉, 松本 耕祐, 南川 勉, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 130 - 131, 日本語

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状
    平岡 佑二郎, 明石 昌也, 松本 耕祐, 榊原 晶子, 木本 明, 長谷川 巧実, 鈴木 泰明, 南川 勉, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 176 - 177, 日本語

  • 当科における歯性上顎洞炎の臨床的検討
    岩田 英治, 明石 昌也, 岸本 恵実, 藤林 淳子, 楠元 順哉, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 220 - 221, 日本語

  • 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討
    岸本 恵実, 古土井 春吾, 藤林 淳子, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2016年07月, 日本口腔感染症学会雑誌, 23(1) (1), 21 - 22, 日本語

  • 歯性感染症が原因となった脳膿瘍の2例
    藤林 淳子, 古土井 春吾, 岸本 恵実, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2016年07月, 日本口腔感染症学会雑誌, 23(1) (1), 25 - 26, 日本語

  • 脳神経外科術後の顎関節症の臨床的検討
    大槻 有美, 明石 昌也, 黄 文蘇, 古森 孝英
    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 111 - 111, 日本語

  • 顎関節に生じた滑膜骨軟骨腫症の1例
    黄 文蘇, 明石 昌也, 大槻 有美, 橘 進彰, 古森 孝英
    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 153 - 153, 日本語

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例
    中西 洋介, 松本 耕祐, 小守 紗也華, 長谷川 巧実, 明石 昌也, 柚鳥 宏和, 橘 進彰, 古森 孝英
    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 41 - 41, 日本語

  • 当科におけるFibro-osseous lesionsの臨床的検討
    松尾 健司, 明石 昌也, 筧 康正, 松本 耕祐, 長谷川 巧実, 南川 勉, 古土井 春吾, 橘 進彰, 古森 孝英
    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 127 - 128, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例
    筧 康正, 明石 昌也, 木本 明, 長谷川 巧実, 南川 勉, 古森 孝英
    (NPO)日本口腔科学会, 2016年07月, 日本口腔科学会雑誌, 65(2) (2), 214 - 214, 日本語

  • 当院における過去8年間の外傷歯患者の臨床統計的検討 顎骨骨折の有無と外傷歯の関係について
    可信 雅彦, 筧 康正, 明石 昌也, 古森 孝英
    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 29 - 29, 日本語

  • 全身麻酔挿管中に生じる歯牙損傷の後ろ向き調査
    小守 紗也華, 筧 康正, 明石 昌也, 古森 孝英
    (一社)日本外傷歯学会, 2016年07月, 日本外傷歯学会総会・学術大会プログラム・抄録集, 16回, 30 - 30, 日本語

  • 当科における顎関節症脱臼の臨床的検討
    大槻 有美, 明石 昌也, 黄 文蘇, 筧 康正, 古森 孝英
    (一社)日本顎関節学会, 2016年07月, 日本顎関節学会雑誌, 28(Suppl.) (Suppl.), 130 - 130, 日本語

  • 4D-CTによる下顎再建術後患者の咀嚼の観察
    明石 昌也, 橋川 和信, 渋谷 恭之, 寺師 浩人, 古森 孝英
    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 147 - 147, 日本語

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価
    明石 昌也, 橋川 和信, 鰐渕 聡, 楠元 順哉, 長谷川 巧実, 南川 勉, 寺師 浩人, 古森 孝英
    (一社)日本頭頸部癌学会, 2016年05月, 頭頸部癌, 42(2) (2), 147 - 147, 日本語

  • 有本 智美, 長谷川 巧実, 岡本 奈々, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英
    (NPO)日本顎変形症学会, 2016年05月, 日本顎変形症学会雑誌, 26(2) (2), 183 - 183, 日本語

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題
    難波 渚, 西井 美佳, 田村 恵利, 富田 和, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英
    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10(1) (1), 199 - 199, 日本語

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題
    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英
    (一社)日本口腔ケア学会, 2016年03月, 日本口腔ケア学会雑誌, 10(1) (1), 225 - 225, 日本語

  • 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例
    松尾 健司, 明石 昌也, 楠元 順也, 藤林 淳子, 渡邊 一博, 南川 勉, 橋川 和信, 古森 孝英
    (NPO)日本口腔科学会, 2016年03月, 日本口腔科学会雑誌, 65(1) (1), 69 - 69, 日本語

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進
    榊原晶子, 榊原俊介, 楠元順哉, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th

  • 当科におけるFibro‐osseous lesionsの臨床的検討
    松尾健司, 明石昌也, 筧康正, 松本耕祐, 長谷川巧実, 南川勉, 古土井春吾, 橘進彰, 古森孝英
    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 159, 日本語

  • 術前18F‐FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性
    米澤奈津季, 南川勉, 北島一宏, 高橋佑輔, 筧康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 231, 日本語

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討
    筧康正, 南川勉, 寺岡駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 234, 日本語

  • 口腔扁平上皮癌患者の遠位レベル(Level4,5)への頸部リンパ節転移が予後に与える影響
    定兼啓倫, 長谷川巧実, 渋谷恭之, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 明石昌也, 南川勉, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 221, 日本語

  • 局所的炭酸ガス投与による皮弁壊死抑制効果
    齊藤泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • 遺伝子解析により確定診断を得た頬粘膜MALTリンパ腫の1例
    筧康正, 明石昌也, 木本明, 長谷川巧実, 南川勉, 古森孝英
    2016年, 日本口腔科学会学術集会プログラム・抄録集, 70th, 286, 日本語

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性
    明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英
    2016年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 34th, 208, 日本語

  • Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo
    Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • 入院加療を要した口腔頸部の重症感染症例の検討
    藤林 淳子, 古土井 春吾, 畑 みどり, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2015年05月, 日本口腔感染症学会雑誌, 22(1) (1), 35 - 36, 日本語

  • 口腔扁平上皮癌臨床検体におけるミトコンドリア量について
    武田大介, 長谷川巧実, 今井佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd

  • Clinical investigation of vascular malformations of the oral region treated by multiple photocoagulation with an Nd:YAG laser
    Matsumoto Kousuke, Ono Masataka, Kitayama Midori, Akashi Masaya, Suzuki Hiroaki, Komori Takahide
    Japanese Stomatological Society, 2015年, Oral science in Japan, 63 - 65, 英語

  • Clinical analysis of the chronological change in bone mass following sinus floor elevation
    Suzuki Hiroaki, Matsumoto Kousuke, Enomoto Yui, Kakei Yasumasa, Kimoto Akira, Akashi Masaya, Komori Takahide
    Japanese Stomatological Society, 2015年, Oral science in Japan, 79 - 82, 英語

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討
    齊藤泉, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 295, 日本語

  • 当科における放射線性顎骨壊死に関する臨床的検討
    鰐渕聡, 明石昌也, 筧康正, 榊原晶子, 長谷川巧実, 南川勉, 古森孝英
    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 237, 日本語

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について
    棚倉万紀子, 長谷川巧実, 米澤奈津季, 武田大介, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 301, 日本語

  • 口腔癌原発巣におけるDual‐time‐point FDG PETの有用性に関する検討
    米澤奈津季, 南川勉, 高橋佑輔, 筧康正, 松井太輝, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    2015年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 33rd, 188, 日本語

  • 【全身疾患と抜歯-最新の知識による適切な対応-】全身疾患を有する患者の抜歯の際に注意すべき基本的事項
    古森 孝英, 明石 昌也, 鈴木 泰明, 榊原 晶子, 木本 明, 南川 勉, 長谷川 巧実, 古土井 春吾
    (株)第一歯科出版, 2015年01月, 歯科医療, 29(1) (1), 4 - 10, 日本語
    [招待有り]
    記事・総説・解説・論説等（学術雑誌）

  • 【全身疾患と抜歯-最新の知識による適切な対応-】循環器系疾患を有する患者の抜歯
    明石 昌也, 古森 孝英
    (株)第一歯科出版, 2015年01月, 歯科医療, 29(1) (1), 11 - 18, 日本語
    [招待有り]
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価
    楠元 順哉, 橋川 和信, 寺師 浩人, 明石 昌也, 榊原 晶子
    (一社)日本形成外科学会, 2014年11月, 日本形成外科学会会誌, 34(11) (11), 852 - 853, 日本語

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討
    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 128 - 128, 日本語

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った1例
    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 浅井 知子, 竹内 純一郎, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 144 - 144, 日本語

  • 当科におけるインプラント242例907本埋入に関する臨床的検討
    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 160 - 160, 日本語

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英
    (公社)日本顎顔面インプラント学会, 2014年11月, Japanese Journal of Maxillo Facial Implants, 13(3) (3), 166 - 166, 日本語

  • 再発胃癌切除後に生じた胸腹壁欠損に対する治療経験
    長谷川 泰子, 野村 正, 橋川 和信, 寺師 浩人, 明石 昌也, 前田 翔
    (一社)日本形成外科学会, 2014年11月, 日本形成外科学会会誌, 34(11) (11), 851 - 851, 日本語
    その他

  • Preformed Reconstruction plateで下顎再建を行った2症例
    竹内 惇平, 明石 昌也, 藤 大補, 高橋 佑輔, 古土井 春吾, 榊原 晶子, 南川 勉, 渋谷 恭之, 古森 孝英
    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63(4) (4), 350 - 350, 日本語

  • 放射線性口腔粘膜炎の重症度判定の客観性を高めるための方策
    川下 由美子, 林田 咲, 船原 まどか, 齋藤 俊行, 西井 美佳, 後藤 郁子, 明石 昌也, 古土井 春吾, 古森 孝英, 梅田 正博
    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63(4) (4), 358 - 358, 日本語

  • 造血器悪性腫瘍患者への歯科的介入に関する前向き検討
    辻 和志, 渋谷 恭之, 岸本 恵実, 明石 昌也, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63(4) (4), 376 - 376, 日本語

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性
    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英
    (NPO)日本口腔科学会, 2014年09月, 日本口腔科学会雑誌, 63(4) (4), 381 - 381, 日本語

  • ビスフォスフォネート関連顎骨壊死症例の転帰に影響する因子についての検討
    古土井 春吾, 楠元 順哉, 畑 みどり, 藤林 淳子, 梶 真人, 後藤 育子, 明石 昌也, 吉位 尚, 古森 孝英
    (一社)日本口腔感染症学会, 2014年06月, 日本口腔感染症学会雑誌, 21(1) (1), 2 - 7, 日本語

  • 当科における重症歯性感染症例の臨床的検討
    藤林 淳子, 古土井 春吾, 小松原 秀紀, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英
    (一社)日本口腔感染症学会, 2014年06月, 日本口腔感染症学会雑誌, 21(1) (1), 49 - 49, 日本語

  • 過去15年間の高齢口腔癌患者に関する臨床的検討
    米澤 奈津季, 南川 勉, 高橋 佑輔, 明石 昌也, 渋谷 恭之, 古森 孝英
    (一社)日本頭頸部癌学会, 2014年05月, 頭頸部癌, 40(2) (2), 158 - 158, 日本語

  • 口腔癌再建術後の感染性合併症 術後CRPのabnormal responseに注目して
    明石 昌也, 橋川 和信, 南川 勉, 渋谷 恭之, 古森 孝英
    (一社)日本頭頸部癌学会, 2014年05月, 頭頸部癌, 40(2) (2), 182 - 182, 日本語

  • 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建
    明石 昌也, 橋川 和信, 寺師 浩人
    (一社)日本形成外科学会, 2014年03月, 日本形成外科学会会誌, 34(3) (3), 238 - 238, 日本語

  • 岩田 英治, 古土井 春吾, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英
    (NPO)日本口腔科学会, 2014年03月, 日本口腔科学会雑誌, 63(2) (2), 246 - 246, 日本語

  • 辻 和志, 渋谷 恭之, 明石 昌也, 古土井 春吾, 古森 孝英
    (NPO)日本口腔科学会, 2014年01月, 日本口腔科学会雑誌, 63(1) (1), 65 - 66, 日本語

  • 口腔癌cN1症例に対する頸部郭清術の郭清範囲についての検討
    筧康正, 南川勉, 高橋佑輔, 松井太輝, 長谷川巧実, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英
    2014年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 32nd, 172, 日本語

  • 舌癌180例のリンパ節転移に関する検討~健側転移について~
    松井太輝, 重田崇至, 南川勉, 明石昌也, 高橋佑輔, 筧康正, 古土井春吾, 渋谷恭之, 古森孝英
    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 140, 日本語

  • 口腔扁平上皮癌術後局所再発症例に関する検討
    高橋佑輔, 南川勉, 筧康正, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 渋谷恭之, 古森孝英
    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 141, 日本語

  • 口腔扁平上皮癌T4症例に対する手術療法の治療成績
    筧康正, 南川勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英
    2013年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 31st, 144, 日本語

  • プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例
    明石 昌也, 橋川 和信, 田原 真也
    (一社)日本形成外科学会, 2012年09月, 日本形成外科学会会誌, 32(9) (9), 711 - 712, 日本語
    [査読有り]
    会議報告等

  • 骨髄移植後GVHD患者に発生した口腔扁平上皮癌の2例
    筧康正, 南川勉, 松井太輝, 榊原晶子, 明石昌也, 三浦真香, 重田崇至, 小松原秀紀, 渋谷恭之, 古森孝英
    2012年, 日本口腔腫瘍学会総会・学術大会プログラム・抄録集, 30th, 211, 日本語

  • 口腔扁平上皮癌に対する頸部郭清術施行205例の頸部転移様相
    松井 太輝, 重田 崇至, 高橋 英哲, 高橋 佑輔, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 99 - 99, 日本語

  • 口腔に発生した紡錘細胞癌における肺転移巣の倍加時間について
    重田 崇至, 南川 勉, 小松原 秀紀, 榊原 晶子, 明石 昌也, 高橋 英哲, 松井 太輝, 渋谷 恭之, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 191 - 191, 日本語

  • 顎口腔再建におけるフェーズコントラスト型CT Angiographyの有用性について
    明石 昌也, 橋川 和信, 南川 勉, 重田 崇至, 榊原 晶子, 古土井 春吾, 渋谷 恭之, 古森 孝英
    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 215 - 215, 日本語

  • 舌癌のstage I・II症例における臨床的検討について
    西村 裕貴, 重田 崇至, 高橋 佑輔, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 324 - 324, 日本語

  • 当科における口底扁平上皮癌手術症例の臨床病理学的検討
    筧 康正, 南川 勉, 松井 太輝, 高橋 英哲, 榊原 晶子, 明石 昌也, 重田 崇至, 渋谷 恭之, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2011年09月, 日本口腔外科学会雑誌, 57(Suppl.) (Suppl.), 200 - 200, 日本語

  • 口腔癌手術における嚥下改善手術に関する臨床的検討
    明石 昌也, 南川 勉, 高橋 英哲, 小國 晶子, 橋川 和信, 古土井 春吾, 渋谷 恭之, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2010年09月, 日本口腔外科学会雑誌, 56(Suppl.) (Suppl.), 140 - 140, 日本語

  • 外側舌リンパ節転移を認めた口底癌の1例
    木本 明, 南川 勉, 小林 正樹, 服部 真季, 明石 昌也, 澁谷 恭之, 横尾 聡, 梅田 正博, 古森 孝英
    (公社)日本口腔外科学会, 2007年06月, 日本口腔外科学会雑誌, 53(6) (6), 400 - 400, 日本語

  • 顎関節症患者の臨床統計的検討
    渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英
    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18(1) (1), 48 - 48, 日本語

  • 当科における顎関節症III a患者の臨床統計的検討
    竹内 純一郎, 渋谷 恭之, 池端 伯子, 藤田 剛史, 明石 昌也, 古森 孝英
    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18(1) (1), 48 - 48, 日本語

  • 当科における顎関節症I・II患者の臨床統計的検討
    池端 伯子, 渋谷 恭之, 竹内 純一郎, 明石 昌也, 藤田 剛史, 古森 孝英
    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18(1) (1), 80 - 80, 日本語

  • 当科における顎関節症III b型患者の臨床統計的検討
    藤田 剛史, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 明石 昌也, 古森 孝英
    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18(1) (1), 80 - 81, 日本語

  • 当科における顎関節症IV型患者の臨床統計的検討
    明石 昌也, 渋谷 恭之, 竹内 純一郎, 池端 伯子, 藤田 剛史, 古森 孝英
    (一社)日本顎関節学会, 2006年04月, 日本顎関節学会雑誌, 18(1) (1), 81 - 81, 日本語

■ 書籍等出版物
  • 改訂版日常の口腔外科 病診連携１ＳＭＡＲＴ＆ＳＭＯＯＴＨ / V-7 顎関節疾患治療の概要を知る
    古森孝英, 横尾聡, 古土井春吾, 綿谷早苗, 梅田正博, 渋谷恭之, 藤岡学, 立石千鶴, 南川勉, 松本耕祐, 榊原晶子, 鈴木泰明, 明石昌也
    その他, 永末書店, 2018年, 日本語
    教科書・概説・概論

  • Oral and Craniofacial Diseases and Disorders / Capter 2: Complications Following Radiation Therapy for Head and Neck Malignancy
    AkashiM, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaK, SeddikMH, SasakiR
    その他, Oxford University Press, 2018年, 英語
    学術書

  • OPEN ACCESS e Books: Oral and Craniofacial Disease and Disorders. / Oral complications following radiation theraphy for head anad neck malignancy
    AkashiM, KomoriT, MinamikawaT, HasegawaT, NishiiM, HashikawaH, SeddikMH, SasakiR
    その他, －, 2018年, 英語
    学術書

  • 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 味覚障害への対応
    明石昌也, 鄒天皓
    その他, 第一歯科出版, 2014年, 日本語
    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 腎障害患者への対応
    明石昌也, 大槻有美, 若林玲奈, 高橋英哲
    その他, 第一歯科出版, 2014年, 日本語
    一般書・啓蒙書

  • 新こんな患者さんが歯科に来たときは？全身疾患・口腔外科疾患に対する診療マニュアル / 三叉神経痛への対応
    明石昌也, 藤原健一, 高田直樹
    その他, 第一歯科出版, 2014年, 日本語
    一般書・啓蒙書

■ 講演・口頭発表等
  • 心血管外科手術周術期の口腔機能管理に関する臨床的検討
    難波渚, 明石昌也, 古森孝英, 桶本翔吾, 小槇 公大, 小川 真人, 坪井 康典, 小林 成美, 後竹 康子, 大北裕
    第3回日本心臓リハビリテーション学会近畿地方会, 2018年02月, 日本語, 日本心臓リハビリテーション学会, 神戸, 国内会議
    口頭発表（一般）

  • 下顎骨壊死における下歯槽神経障害の臨床病理学的検討
    平岡佑二郎, 明石昌也, 重岡学, 楠元順哉, 長谷川巧実, 古森孝英
    第62回日本口腔外科学会総会・学術大会, 2017年10月, 日本語, 京都, 国内会議
    口頭発表（一般）

  • FDG PET-CTは重症下顎放射線性顎骨壊死の切除範囲決定に有用か?．
    明石昌也, 橋川和信, 楠元順哉, 古土井春吾, 古森孝英
    第62回日本口腔外科学会総会・学術大会（京都）, 2017年10月, 日本語, 日本口腔外科学会, 京都, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 神経症状を伴った下顎放射線性顎骨壊死における下歯槽神経の病理組織学的研究．
    明石昌也, 楠元順哉, 長谷川巧実, 南川勉, 橋川和信, 古森孝英
    第41回日本頭頸部癌学会（京都）, 2017年06月, 日本語, 日本頭頸部癌学会, 京都, 国内会議
    口頭発表（一般）

  • 【シンポジウム2「頭頸部再建に残された課題－二次再建の挑戦と課題－」】重症下顎骨放射線骨髄炎に対する手術―デブリドマン範囲を病理組織学的検討結果から考察する―．
    橋川和信, 明石昌也, 楠元順哉, 野村正, 寺師浩人
    第60回日本形成外科学会総会・学術集会（大阪）, 2017年04月, 日本語, 日本形成外科学会, 大阪, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 4DCT EVALUATION OF CONDYLAR MOVEMEN IN PATIENTS UNDERWENT MANDIBULAR RECONSTRUCTION．
    Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Takumi Hasegawa, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori
    23nd International Conference on Oral and Maxillofacial Surgery（Hong Kong）, 2017年03月, 日本語, International Conference on Oral and Maxillofacial Surgery, Hong Kong, 海外, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌では外的刺激受容体（TRPVチャネル）の発現が亢進する．
    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川勉, 橋川和信, 古森孝英
    第35回口腔腫瘍学会（福岡）, 2017年01月, 日本語, 口腔腫瘍学会, 福岡, 国内会議
    口頭発表（一般）

  • 内視鏡支援下で上顎洞迷入インプラントの摘出後に骨造成術を行った1例
    山下淳也, 鈴木 泰明, 筧康正, 木本 明, 長谷川巧実, 明石昌也, 古森孝英
    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議
    ポスター発表

  • 当科におけるインプラント埋入症例と喪失リスクに関する臨床的検討
    片岡侑嗣, 長谷川巧実, 綿越健太, 浅井雅敏, 有本智美, 明石昌也, 鈴木 泰明, 古森孝英
    第20回日本顎顔面インプラント学会, 2016年12月, 日本語, 日本顎顔面インプラント学会, 東京, 国内会議
    ポスター発表

  • チタンミニプレートと固定用スクリューの関与が疑われた乾癬様皮疹の1例
    可信雅彦, 明石昌也, 古土井春吾, 古森孝英
    第28回口腔科学会近畿地方部会, 2016年12月, 日本語, 日本口腔科学会, 大阪, 国内会議
    口頭発表（一般）

  • 腓骨皮弁による下顎再建におけるミニプレートと再建用プレートの比較
    平岡佑二郎, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 放射線性顎骨壊死の病理組織学的検討
    鰐渕 聡, 明石昌也, 岩田英治, 筧 康正, 楠元順哉, 南川 勉, 古土井春吾, 橋川和信, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 頭頸部領域の蜂窩識炎に対する好中球/リンパ球比，血小板/リンパ球比の有用性の検討
    楠元順哉, 古土井春吾, 岸本惠実, 岩田英治, 明石昌也, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 頭頸部蜂窩織炎に対する好中球/リンパ球比，血小板/リンパ球比の有用性の検討
    楠元 順哉, 古土井 春吾, 岸本 恵実, 岩田 英治, 藤林 淳子, 明石 昌也, 古森 孝英
    第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議
    口頭発表（一般）

  • 当科における舌癌・口底癌手術症例の再建方法に関する検討
    綿越健太, 南川 勉, 米澤奈津季, 筧 康正, 長谷川巧実, 榊原晶子, 明石昌也, 古土井春吾, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 当科における心臓血管外科開胸手術患者に対する周術期口腔機能管理の臨床的検討
    難波 渚, 明石昌也, 西井美佳, 楠元順哉, 松本耕祐, 長谷川巧実, 古土井春吾, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 当科における口腔癌患者の口腔内細菌数の変化とSSIについて
    小守紗也華, 長谷川巧実, 西井美佳, 明石昌也, 古土井春吾, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 造血器悪性腫瘍患者に対する化学療法中の歯性感染症が原因の敗血症発症率
    岸本惠実, 明石昌也, 辻 和志, 楠元順哉, 古土井春吾, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 舌癌切除後の前腕皮弁再建における 切除検体サイズと皮弁サイズの 相関と機能の検討
    榊原 晶子, 楠元 順哉, 長谷川 巧実, 明石 昌也, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英
    第61回公益社団法人日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 公益社団法人日本口腔外科学会総会・学術大会, 千葉市, 国内会議
    口頭発表（一般）

  • 舌癌切除後の前腕皮弁再建における切除検体サイズと皮弁サイズの僧冠と機能の検討
    榊原晶子, 楠元順哉, 長谷川巧実, 明石昌也, 南川勉, 古土井春吾, 橋川和信, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 口腔癌放射線治療における有効な新規併用療法の探索
    岩田英治, 長谷川巧実, 武田大介, 斉藤 泉, 有本智美, 明石昌也, 南川 勉, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 口腔癌術後リンパ浮腫に関するCT解析
    寺岡 駿, 明石昌也, 筧 康正, 楠元順哉, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 局所的炭酸ガス投与による皮弁壊死抑制効果
    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果
    有本智美, 長谷川巧実, 齊藤 泉, 岩田英治, 武田大介, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 遠位レベル(Level IV,V)への頸部リンパ節転移を生じた口腔扁平上皮癌患者の予後に関する後ろ向き観察研究
    長谷川巧実, 南川 勉, 米澤奈津季, 高橋佑輔, 筧 康正, 榊原晶子, 明石昌也, 古森孝英
    第61回日本口腔外科学会総会・学術大会, 2016年11月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 口腔癌術後に消化管穿孔を発症した1例
    高橋淳子, 古土井春吾, 岸本恵美, 岩田英治, 楠元順哉, 梶 真人, 後藤育子, 明石昌也, 古森孝英
    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議
    口頭発表（一般）

  • 結節性硬化症患者に対する口腔衛生管理の現状ーエベロリムスによる口内炎への対応ー
    西井美佳, 古土井春吾, 岸本惠実, 岩田英治, 楠元順哉, 明石昌也, 古森孝英
    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議
    口頭発表（一般）

  • スニチニブに関連して発症したと考えられる下顎骨壊死の1例
    岩田英治, 古土井春吾, 岸本惠実, 高橋淳子, 楠元順哉, 後藤育子, 明石昌也, 古森孝英
    第25回日本口腔感染症学会総会・学術大会, 2016年10月, 日本語, 日本口腔感染症学会, 神戸, 国内会議
    口頭発表（一般）

  • Development of the new treatment of OSCC by local application of transcutaneous carbon dioxide
    Iwata E, Hasegawa T, Takeda D, Saito I, Arimoto S, Akashi M, Minamikawa T, Komori T
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw
    Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Megumi Kishimoto, Eiji Iwata, Yasumasa Kakei, Junya Kusumoto, Kousuke Matsumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Shungo Furudoi, Takahide Komori
    The 23th Congress of EACMFS, 2016年09月, 英語, Congress of EACMFS, London, イギリス, 国際会議
    口頭発表（一般）

  • Determination of resection margins by using a combination of CT, MRI, PET, and 3D model in osteoradionecrosis of the jaw
    Akashi M, Hashikawa K, Wanifuchi S, Kishimoto M, Iwata E, Kakei Y, Kusumoto J, Matsumoto K, Sakakibara A, Hasegawa T, Minamikawa T, Furudoi S, Komori T
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • Changes of cell junctions induced by EGFR inhibition in oral squamous cell carcinomas
    Kakei Y, Akashi M, Teraoka S, Hasegawa T, Komori T
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • A clinical study of injured patients treated with dental implants
    Suzuki H, Takeuchi J, Matsuo K, Kakei Y, Kimoto A, Hasegawa T, Akashi M, Chikazu D, Komori T
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS), 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • A clinical study of 12 implants resulting in implant removal
    Takahashi D, Suzuki H, Kakei Y, Hasegawa T, Akashi M, Minamikawa T, Takahide Komori
    The 23rd European Association for Cranio Maxillo-Facial Surgery (EACMFS),, 2016年09月, 日本語, UKレーザー歯学会, London, UK, 国際会議
    ポスター発表

  • 頬部に認めた孤立性線維性腫瘍の1例
    鰐渕 聡, 大槻有美, 後藤育子, 明石昌也, 鈴木泰明, 南川 勉, 古土井春吾, 古森孝英
    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 脳神経外科術後の顎関節症の臨床的検討
    大槻有美, 明石昌也, 黄文蘇, 筧康正, 古森孝英
    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議
    口頭発表（一般）

  • 当科における心臓血管外科周術期の口腔機能管理に関する実態と今後の課題
    難波 渚, 明石昌也, 冨田 和, 田村恵利, 澤田麻衣子, 西井美佳, 長谷川巧実, 古土井春吾, 古森孝英
    第32回兵庫県歯科医学大会, 2016年07月, 日本語, 兵庫県歯科医師会, 神戸, 国内会議
    口頭発表（一般）

  • 当科における顎関節脱臼の臨床的検討
    大槻有美, 明石昌也, 黄文蘇, 筧康正, 古森孝英
    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議
    ポスター発表

  • 当院における過去8年間の外傷歯患者の臨床統計的検討 ～顎骨骨折の有無と外傷歯の関係について～
    可信雅彦, 筧 康正, 小守紗也華, 明石昌也, 古土井春吾, 古森孝英
    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議
    口頭発表（一般）

  • 造血器悪性腫瘍に対する化学療法中のD-indexと口腔内感染性合併症との関連についての検討
    明石 昌也, 岸本 恵実, 辻 和志, 楠元 順哉, 薬師神 公和, 川本 晋一郎, 岡村 篤夫, 松岡 広, 古土井 春吾, 古森 孝英
    第14回日本臨床腫瘍学会, 2016年07月, 日本語, 日本臨床腫瘍学会, 神戸市, 国内会議
    口頭発表（一般）

  • 全身麻酔挿管中に生じる歯の損傷も後ろ向き調査
    小守紗也華, 筧 康正, 可信雅彦, 明石昌也, 古土井春吾, 古森孝英
    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議
    口頭発表（一般）

  • 顎関節に生じた滑膜骨軟骨腫症の1例
    黄文蘇, 明石昌也, 大槻有美, 橘進彰, 古森孝英
    第29回日本顎関節学会総会・学術大会, 2016年07月, 日本語, 日本顎関節学会, 箱根, 国内会議
    ポスター発表

  • 下顎歯肉癌の精査においてCowden症候群の合併が示唆された1例
    榎本由依, 明石昌也, 平岡佑二郎, 船原隆一郎, 南川 勉, 古森孝英
    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 下顎骨骨折の治療を行ったLennox-Gastaut症候群患児の1例
    中西洋介, 松本耕祐, 小守紗也華, 長谷川巧実, 明石昌也, 柚鳥宏和, 橘進彰, 古森孝英
    第16回日本外傷歯学会総会・学術大会, 2016年07月, 日本語, 日本外傷歯学会, 神戸, 国内会議
    口頭発表（一般）

  • 15歳女児に生じた舌扁平上皮癌の1例
    綿越健太, 南川勉, 寺岡 駿, 明石昌也, 古森孝英
    第47回日本口腔外科学会近畿支部学術集会, 2016年07月, 日本語, 日本口腔外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価
    明石昌也, 橋川和信, 鰐渕 聡, 楠元順哉, 長谷川巧実, 南川 勉, 寺師浩人, 古森孝英
    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議
    口頭発表（一般）

  • 歯科インプラント埋入のためのデンタルCTを用いた移植腓骨の形態評価
    明石 昌也, 橋川 和信, 鰐渕聡, 楠元 順哉, 長谷川巧実, 南川勉, 寺師 浩人, 古森 孝英
    第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議
    口頭発表（一般）

  • 下顎枝垂直骨切り術後の骨癒合に対する低出力超音波パルス(LIPUS)の効果
    有本智美, 長谷川巧実, 岡本奈那, 塩屋園敦, 立石千鶴, 明石昌也, 鈴木泰明, 古土井春吾, 古森孝英
    第26回日本顎変形症学会総会・学術大会, 2016年06月, 日本語, 日本顎変形症学会, 東京, 国内会議
    ポスター発表

  • 4D-CTによる下顎再建術後患者の咀嚼の観察
    明石昌也, 橋川和信, 渋谷恭之, 寺師浩人, 古森孝英
    第40回日本頭頸部癌学会総会・学術大会, 2016年06月, 日本語, 日本頭頸部癌学会, 埼玉, 国内会議
    口頭発表（一般）

  • 4D-CTによる下顎再建術後患者の咀嚼の観察
    明石 昌也, 橋川 和信, 渋谷恭之, 寺師 浩人, 古森 孝英
    第40回日本頭頸部癌学会, 2016年06月, 日本語, 日本頭頸部癌学会, さいたま市, 国内会議
    口頭発表（一般）

  • 放射線性顎骨鋭氏壊死症例に対する画像診断を中心とした臨床的検討
    鰐渕 聡, 明石昌也, 岩田英治, 楠元順哉, 松本耕佑, 南川 勉, 古土井春吾, 古森孝英
    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議
    口頭発表（一般）

  • 当科における埋伏智歯抜歯後神経系合併症に対する治療法の現状
    平岡佑二郎, 明石昌也, 松本耕祐, 榊原晶子, 木本 明, 長谷川巧実, 鈴木泰明, 南川勉, 古土井春吾, 古森孝英
    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議
    口頭発表（一般）

  • 当科における歯性上顎洞炎の臨床的検討
    岩田英治, 明石昌也, 岸本恵実, 藤林淳子, 楠元順哉, 古土井春吾, 古森孝英
    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議
    ポスター発表

  • 当科におけるFibro-osseous lesionsの臨床的検討
    松尾健司, 明石昌也, 筧 康正, 松本耕祐, 長谷川巧実, 南川 勉, 古土井春吾, 橘進彰, 古森孝英
    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議
    口頭発表（一般）

  • 中咽頭癌化学放射線治療患者における口腔衛生管理-強度変調放射線治療(IMRT)と従来型放射線治療(RT)の比較
    西井美佳, 筧 康正, 冨田 和, 難波 渚, 田村恵利, 澤田麻衣子, 明石昌也, 古土井春吾, 古森孝英
    第13回日本口腔ケア学会総会・学術大会, 2016年04月, 日本語, 日本口腔ケア学会, 千葉, 国内会議
    口頭発表（一般）

  • 遺伝子解析により確定診断を得たMALTリンパ腫の1例
    筧 康正, 明石昌也, 木本 明, 長谷川巧実, 南川 勉, 古森孝英
    第70回日本口腔科学会総会・学術大会, 2016年04月, 日本語, 日本口腔科学会, 福岡, 国内会議
    口頭発表（一般）

  • 腓骨皮弁採取部における一期縫縮と植皮の比較
    渡邊一博, 明石昌也, 楠本順哉, 松本耕祐, 木本 明, 榊原晶子, 長谷川巧実, 南川勉, 橋川和信, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 術前18F-FDG PET/CT撮影での口腔癌原発巣における定量評価の有用性
    米澤奈津季, 南川 勉, 北島一宏, 高橋佑輔, 筧 康正, 榊原晶子, 長谷川巧実, 明石昌也, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 口腔扁平上皮癌被膜外浸潤症例の臨床病理学的検討
    筧 康正, 南川 勉, 寺岡 駿, 米澤奈津季, 高橋佑輔, 長谷川巧実, 明石昌也, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 口腔扁平上皮癌患者の遠位レベル（level4,5）への頸部リンパ節転移が予後に与える影響
    定兼啓倫, 長谷川巧実, 渋谷恭之, 米澤奈津季, 武田大介, 高橋佑輔, 筧 康正, 明石昌也, 南川 勉, 古土井春吾, 橋川和信, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 口腔扁平上皮癌における外的刺激受容体（TRPVチャネル）の発現
    榊原 晶子, 榊原 俊介, 楠元 順哉, 武田 大介, 長谷川 巧実, 明石 昌也, 南川 勉, 橋川 和信, 古森 孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌における外的刺激受容体(TRPVチャネル)の発現亢進
    榊原晶子, 榊原俊介, 楠元順哉, 武田大介, 長谷川巧実, 明石昌也, 南川 勉, 橋川和信, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 局所的炭酸ガス投与による皮弁壊死抑制効果
    齊藤 泉, 長谷川巧実, 武田大介, 岩田英治, 有本智美, 筧康正, 高橋佑輔, 榊原晶子, 明石昌也, 南川勉, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性（ポスター発表）
    明石昌也, 筧 康正, 榊原晶子, 長谷川巧実, 南川 勉, 橋川和信, 古森孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会, 横浜, 国内会議
    ポスター発表

  • 移植腓骨と下顎骨の癒合における骨膜温存の重要性
    明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 橋川 和信, 古森 孝英
    第34回日本口腔腫瘍学会総会・学術大会, 2016年01月, 日本語, 日本口腔腫瘍学会総会・学術大会, 横浜市, 国内会議
    口頭発表（一般）

  • 再建プレート露出に対する二期再建術前PET/CTが膿瘍の検知に有用であった1例
    松尾 健司, 明石 昌也, 楠元 順哉, 藤林 淳子, 渡邊 一博, 南川 勉, 橋川 和信, 古森 孝英
    第27回NPO法人日本口腔科学会近畿地方部会．, 2015年11月, 日本語, 日本口腔外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 化学放射線療法による口腔粘膜炎の重症度を予測する因子についての検討
    岸本 恵実, 古土井 春吾, 藤林 淳子, 西井 美佳, 岩田 英治, 楠元 順哉, 梶 真人, 後藤 育子, 明石 昌也, 古森 孝英
    第24回日本口腔感染症学会総会．, 2015年11月, 日本語, 日本口腔感染症学会, 神奈川, 国内会議
    口頭発表（一般）

  • Targeted Disruption of JCAD/KIAA1462, a Coronary Artery Disease-associated Gene Product, Inhibits Angiogenic Processes in Vitro and in Vivo.
    Tetsuya Hara, Tomoko Monguchi, Masaya Akashi, Noriko Iwamoto, Kenta Mori, Ryuji Toh, Yasuhiro Irino, Masakazu Shinohara, Mikio Furuse, Tatsuro Ishida, Ken-ichi Hirata
    American Heart Association Scientic Session 2015., 2015年11月, 英語, American Heart Association, Orlando, USA, Background: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regul, 国際会議
    ポスター発表

  • 入院管理下で口腔外科小手術を施行した患者に関する臨床統計
    棚倉 万紀子, 筧 康正, 南川 勉, 高橋 佑輔, 米澤 奈津季, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 超音波断層法による口腔癌頸部リンパ節転移の検討
    筧 康正, 南川 勉, 棚倉 万紀子, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 進展例の放射線性顎骨壊死の外科的治療におけるPETの有用性.
    明石 昌也, 橋川 和信, 南川 勉, 古土井 春吾, 古森 孝英
    第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 三次元実態模型を用いた手術シミュレーションー当科における最近の使用経験
    鰐渕 聡, 明石 昌也, 橋川和信, 筧 康正, 松本 耕祐, 木本 明, 長谷川 巧実, 南川 勉, 古土井 春吾, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌における外的刺激受容体の発現
    榊原 晶子, 楠元 順哉, 明石 昌也, 南川 勉, 古森 孝英
    第60回日本口腔外科学会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 口腔癌原発巣の術前18F-FDG PET/CT撮影に関する検討
    米澤 奈津季, 南川 勉, 北島一宏, 高橋 佑輔, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 経皮的炭酸ガス投与による口腔癌上皮間葉移行の抑制効果
    岩田 英治, 長谷川 巧実, 武田 大介, 明石 昌也, 南川 勉, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • ロケーター・マグネット付きカスタムバーによるインプラントオーバーデンチャー関連合併症
    有本 智美, 長谷川 巧実, 斉藤 泉, 岩田 英治, 武田 大介, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英
    第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • Observation of Mastication in Patients Underwent Mandibular Reconstruction by 4D-CT with 320 Detector-Row Scanning : A Preliminary Report,
    Akashi M, Shibuya Y, Takahashi S, Hashikawa K, Hasegawa T, Kakei Y, Negi N, Sekitani T, Komori T
    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議
    口頭発表（一般）

  • Incidence of venousthromboembolism after oral surgery with simultaneous reconstruction,
    Kakei Y, Akashi M, Shigeta T, Takahashi Y, Mastui T, Sakakibara A, Hasegawa T, Minamikawa T, Komori T
    22nd International conference on oral and maxilofacial surgery,, 2015年10月, 英語, メルボルン, オーストラリア, 国際会議
    口頭発表（一般）

  • Evaluating the changes in the amount of bone augmentation after sinus lift using panoramic radiography: Comparison evaluations based on CT images．
    松尾 健司, 鈴木 泰明, 松本 耕祐, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 順一郎, 古森 孝英
    第60回日本口腔外科学会総会．, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • A novel strategy aimed at apoptosis via the mitochondrial pathway and improving hypoxia in oral squamous cell carcinoma.．
    武田 大介, 長谷川 巧実, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英
    第60回日本口腔外科学会総会, 2015年10月, 日本語, 日本口腔外科学会, 名古屋, 国内会議
    口頭発表（一般）

  • 当科における下顎の骨折線上の歯に関する臨床的検討
    北山 美登里, 鈴木 泰明, 小守 紗也華, 松本 耕祐, 明石 昌也, 古森 孝英
    第15回日本外傷歯学会，, 2015年07月, 日本語, 日本外傷歯学会, 福岡, 国内会議
    口頭発表（一般）

  • 混合歯列期の下顎骨骨折に対し非観血的整復治療を行った1例
    小守 紗也華, 松本 耕祐, 北山 美登里, 明石 昌也, 立石 千鶴, 鈴木 泰明, 古森 孝英
    第15回日本外傷歯学会，, 2015年07月, 日本語, 日本外傷歯学会, 福岡, 国内会議
    口頭発表（一般）

  • 当院における周術期口腔機能管理に関する実態調査と今後の課題
    田村 惠利, 西井 美佳, 冨田 和, 難波 渚, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英
    第12回日本口腔ケア学会総会・学術大会．, 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議
    口頭発表（一般）

  • 外科的矯正手術前後における顎関節症状および顎関節MRI画像の変化.
    定兼 啓倫, 長谷川 巧実, 有本 智美, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英
    第25回日本顎変形症学会総会．, 2015年06月, 日本語, 日本顎変形症学会, 東京, 国内会議
    口頭発表（一般）

  • Sequential evaluation of bone union of transferred fibula flaps in reconstructed mandibles.
    Akashi M, Hashikawa K, Kakei Y, Sakakibara A, Hasegawa T, Minamikawa T, Komori T
    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 2015年06月, 英語, 神戸, 国内会議
    口頭発表（一般）

  • Decreased mitochondrial copy numbers in oral squamous cell carcinoma.
    Takeda D, Hasegawa T, Sakakibara A, Akashi M, Minamikawa T, Komori T
    "The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan society for Head and Neck Cancer．, 2015年06月, 英語, 神戸, 国内会議
    口頭発表（一般）

  • -
    難波 渚, 西井 美佳, 冨田 和, 田村 恵利, 長谷川 巧実, 明石 昌也, 古土井 春吾, 古森 孝英
    第12回日本口腔ケア学会総会・学術大会．, 2015年06月, 日本語, 日本口腔ケア学会, 山口, 国内会議
    口頭発表（一般）

  • 下顎骨骨髄炎との鑑別が困難であった下顎歯肉悪性腫瘍の1例
    渡邊 一博, 古土井 春吾, 筧 康正, 明石 昌也, 南川 勉, 古森 孝英
    第46回日本口腔外科学会近畿支部学術集会．, 2015年03月, 日本語, 日本口腔外科学会, 神戸, 国内会議
    口頭発表（一般）

  • 移植非骨と下顎骨の骨癒合に関する経時的評価－パノラマX線とCT画像の比較－
    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉
    第109回関西形成外科学会地方会．, 2015年03月, 日本語, 関西形成外科学会, 京都, 国内会議
    口頭発表（一般）

  • 当科における頸部郭清術術後の頸部ドレーンに関する臨床的検討
    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    口頭発表（一般）

  • 当科における放射線性顎骨壊死に関する臨床的検討
    鰐渕 聡, 明石 昌也, 筧 康正, 榊原 晶子, 長谷川 巧実, 南川 勉, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    口頭発表（一般）

  • 当科における口腔扁平上皮癌遠隔転移例の臨床的検討とリスク因子について
    棚倉 万紀子, 長谷川 巧実, 米澤 奈津季, 武田 大介, 高橋 佑輔, 筧 康正, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌臨床検体におけるミトコンドリア量について
    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    ポスター発表

  • 口腔癌手術症例におけるmodified Glasgow Prognostic Score(mGPS)を用いた長期予後に関する検討
    平岡 佑二郎, 南川 勉, 米澤 奈津季, 高橋 佑輔, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    ポスター発表

  • 口腔癌原発巣におけるDual-time-point FDG PETの有用性
    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森 孝英
    第33回日本口腔腫瘍学会, 2015年01月, 日本語, 日本口腔腫瘍学会, 奈良, 国内会議
    口頭発表（一般）

  • 下顎枝垂直骨切り術後の近位骨片と下顎頭変化の評価
    有本 智美, 長谷川 巧実, 定兼 啓倫, 岡本 奈那, 塩屋園 敦, 立石 千鶴, 明石 昌也, 鈴木 泰明, 古土井 春吾, 古森 孝英
    第25回日本顎変形症学会総会．, 2015年01月, 日本語, 日本顎変形症学会, 東京, 国内会議
    口頭発表（一般）

  • 放射線治療後の甲状腺機能低下による低ナトリウム血症の1例
    村田 陽太郎, 長谷川 巧実, 八橋 明子, 明石 昌也, 南川 勉, 古土井 春吾, 古森 孝英
    第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議
    口頭発表（一般）

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    明石 昌也, 橋川 和信, 榊原 晶子, 楠元 順哉
    第108回関西形成外科学会学術集会, 2014年12月, 日本語, 関西形成外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 経口的ビタミンB12投与が著効したHUNTER舌炎の1例
    中田 和甫史, 若林 玲奈, 明石 昌也, 古森 孝英
    第26回日本口腔科学会近畿地方部会, 2014年12月, 日本語, 日本口腔科学会, 京都, 国内会議
    口頭発表（一般）

  • 当科における広範囲顎骨支持型インプラント補綴の臨床統計的検討
    今井 佑輔, 長谷川 巧実, 川畑 真哉, 武田 大介, 明石 昌也, 鈴木 泰明, 古森 孝英
    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議
    口頭発表（一般）

  • 当科におけるインプラント242例907本埋入に関する臨床的検討
    川畑 真哉, 長谷川 巧実, 今井 佑輔, 木本 明, 明石 昌也, 鈴木 泰明, 古森 孝英
    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議
    口頭発表（一般）

  • 著明な上顎洞粘膜肥厚を有する患者に洞底挙上術後インプラント治療を行った症例
    榎本 由依, 鈴木 泰明, 木本 明, 長谷川 巧実, 明石 昌也, 竹内 純一郎, 古森 孝英
    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議
    口頭発表（一般）

  • 小児の顔面多発骨折症例の経験
    大﨑 健夫, 川北 育子, 北野 豊明, 桒水流 健二, 明石 昌也
    第32回日本頭蓋顎顔面外科学会学術集会, 2014年11月, 日本語, 日本頭蓋顎顔面外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 歯科インプラント埋入のためのCT画像を用いた移植腓骨の形態評価
    明石 昌也, 渋谷 恭之, 鰐渕 聡, 木本 明, 長谷川 巧実, 鈴木 泰明, 古森 孝英
    第18回日本顎顔面インプラント学会学術大会, 2014年11月, 日本語, 日本顎顔面インプラント学会, 島根, 国内会議
    口頭発表（一般）

  • 入院加療を要した口腔頸部の重症感染症例の検討
    藤林 淳子, 古土井 春吾, 畑 みどり, 楠元 順哉, 後藤 育子, 明石 昌也, 古森 孝英
    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議
    口頭発表（一般）

  • 頭頸部領域における壊死性筋膜炎に対するLRINECスコアの有用性の検討
    楠元 順哉, 古土井 春吾, 明石 昌也, 榊原 晶子, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 当科における口腔癌患者の術後せん妄に関する臨床的検討
    齊藤 泉, 長谷川 巧実, 米澤 奈津季, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 明石 昌也, 南川 勉, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 当院における心臓血管外科患者における周術期口腔機能管理
    藤 大補, 明石 昌也, 古土井 春吾, 西井 美佳, 後藤 育子, 古森 孝英
    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議
    口頭発表（一般）

  • 低出力超音波パルスの下顎骨骨折血腫細胞のBMP発現における効果
    黄 文蘇, 長谷川 巧実, 今井 佑輔, 武田 大介, 明石 昌也, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 上顎部分切除後の遊離前腕皮弁再建群と非再建群の比較
    明石 昌也, 渋谷 恭之, 楠元 順哉, 榊原 晶子, 長谷川 巧実, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 抗RANKLモノクローナル抗体（デノスマブ）に発症した顎骨壊死の1例
    岩田 英治, 明石 昌也, 長谷川 巧実, 古土井 春吾, 古森 孝英
    第23回日本口腔感染症学会総会, 2014年10月, 日本語, 日本口腔感染症学会, 伊丹, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌N0症例への予防的頸部郭清の検討：T1-2とT3-4の比較
    八橋 明子, 南川 勉, 松井 太輝, 高橋 佑輔, 米澤 奈津季, 筧 康正, 榊原 晶子, 長谷川 巧実, 明石 昌也, 古森孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 口腔癌手術における輸血療法の現状
    米澤 奈津季, 南川 勉, 高橋 佑輔, 筧 康正, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷恭之, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 口腔癌に対する救済手術についての検討
    筧 康正, 南川 勉, 米澤 奈津季, 高橋 佑輔, 松井 太輝, 榊原 晶子, 長谷川 巧実, 明石 昌也, 渋谷 恭之, 古森孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • 局所的炭酸ガス投与による口腔癌新規治療法の開発
    武田 大介, 長谷川 巧実, 今井 佑輔, 榊原 晶子, 明石 昌也, 南川 勉, 渋谷 恭之, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 化学放射線療法中の中咽頭癌患者における口腔乾燥の経時的変化
    西井 美佳, 明石 昌也, 筧 康正, 長谷川 巧実, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • フェーズラグCT（pl-CTA）による顎骨周囲の脈管の評価
    榊原 晶子, 榊原 俊介, 長谷川 巧実, 明石 昌也
    第59回日本口腔外科学会総会・学術集会, 2014年10月, 日本語, 日本口腔外科学会, 幕張, 国内会議
    口頭発表（一般）

  • フェーズラグCTA（ｐｌ－CTA）による顎動静脈分岐の評価
    榊原 晶子, 榊原 俊介, 楠元 順哉, 長谷川 巧実, 明石 昌也, 鈴木 泰明, 南川 勉, 古土井 春吾, 橋川 和信, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

  • ビスフォスフォネート関連顎骨壊死症例のCT画像における臨床的検討
    岩田 英治, 明石 昌也, 楠元 順哉, 長谷川 巧実, 後藤 育子, 古土井 春吾, 古森 孝英
    第59回日本口腔外科学会総会, 2014年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    ポスター発表

  • 対側オトガイ部の知覚異常を初発症状としたびまん性大細胞型B細胞性リンパ腫の1例
    高端 大希, 明石 昌也, 高橋 佑輔, 辻 和志, 西尾 良介, 南川 勉, 古森 孝英
    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議
    口頭発表（一般）

  • 口腔癌再建術後の感染性合併症－術後CRPのabnormal responseに注目して－
    明石 昌也, 橋川 和信, 南川 勉, 渋谷 恭之, 古森 孝英
    第38回日本頭頸部癌学会, 2014年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議
    口頭発表（一般）

  • 顎関節部に限局する線維-骨性病変の1例
    八橋 明子, 渋谷 恭之, 後藤 育子, 明石 昌也, 松井 太輝, 古森 孝英
    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議
    口頭発表（一般）

  • 過去15年間の高齢口腔癌患者に関する臨床的検討
    米澤 奈津季, 南川 勉, 高橋 佑輔, 明石 昌也, 渋谷 恭之, 古森 孝英
    第38回日本頭頸部癌学会, 2014年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議
    口頭発表（一般）

  • 栄養・輸液サポートチームにおける歯科的介入について
    若林 玲奈, 渋谷 恭之, 今井 佑輔, 黒木 信祐, 後藤 育子, 明石 昌也, 古土井 春吾, 古森 孝英
    第45回日本口腔外科学会近畿地方会, 2014年06月, 日本語, 日本口腔外科学会, 奈良, 国内会議
    口頭発表（一般）

  • 造血気悪性腫瘍患者への歯科的介入に関する前向き検討
    辻 和志, 渋谷 恭之, 岸本 恵実, 棚倉 万紀子, 明石 昌也, 古土井 春吾, 古森 孝英
    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議
    口頭発表（一般）

  • 口腔内細菌数が放射線性口腔粘膜炎に及ぼす影響について
    後藤 育子, 古土井 春吾, 西井 美佳, 楠本 順哉, 梶 真人, 明石 昌也, 古森 孝英
    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議
    ポスター発表

  • 口腔癌再建術後の頸部感染評価目的でのCTの有用性
    明石 昌也, 古土井 春吾, 南川 勉, 木本 明, 榊原 晶子, 長谷川 巧実, 後藤 育子, 渋谷 恭之, 古森 孝英
    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議
    口頭発表（一般）

  • Preformed Reconstruction plateで下顎再建を行った2症例
    竹内 惇平, 古土井 春吾, 藤 大補, 高橋 佑輔, 明石 昌也, 榊原 晶子, 南川 勉, 渋谷 恭之, 古森 孝英
    第68回日本口腔科学会学術総会, 2014年05月, 日本語, 日本口腔科学会, 東京, 国内会議
    口頭発表（一般）

  • パネルディスカッション3. ビデオで伝えたい私の手順
    野村 正, 榊原 俊介, 高須 啓之, 明石 昌也, 橋川 和信, 田原 真也, 寺師 浩人
    第19回日本形成外科手術手技学会, 2014年02月, 日本語, 日本形成外科手術手技学会, 愛知, 国内会議
    公開講演，セミナー，チュートリアル，講習，講義等

  • 高齢口腔癌患者に関する臨床的検討
    米澤 奈津季, 南川 勉, 明石 昌也, 高橋 佑輔, 重田 崇至, 渋谷 恭之, 古森 孝英
    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議
    口頭発表（一般）

  • 口腔癌cN1症例に対する頸部郭清術の廓清範囲についての検討
    筧 康正, 南川 勉, 高橋 佑輔, 松井 太輝, 長谷川 巧実, 明石 昌也, 重田 崇至, 古土井 春吾, 渋谷 恭之, 古森 孝英
    第32回日本口腔腫瘍学会, 2014年01月, 日本語, 日本口腔腫瘍学会, 札幌, 国内会議
    口頭発表（一般）

  • 遊離腓骨皮弁移植におけるMR Angiographyによる下肢血管解剖の術前評価
    楠元 順哉, 橋川 和信, 明石 昌也, 榊原 晶子, 寺師 浩人
    第105回日本形成外科学会関西支部学術集会, 2013年12月, 日本語, 本形成外科学会, 大阪, 国内会議
    口頭発表（一般）

  • 口腔外に肉芽形成をきたしたビスフォスフォネート関連顎骨壊死の1例
    岩田英治, 古土井春吾, 楠元順哉, 後藤育子, 明石昌也, 古森孝英
    第25回日本口腔科学会近畿地方部会, 2013年12月, 日本語, 日本口腔科学会, 大阪, 国内会議
    口頭発表（一般）

  • 胃癌術後の腹壁再発切除術により生じた 胸腹壁欠損に対する治療経験
    長谷川 泰子, 野村 正, 明石 昌也, 前田 翔, 橋川 和信, 寺師 浩人
    第105回関西形成外科学会学術集会, 2013年12月, 日本語, 関西形成外科学会学術集会, 大阪市, 国内会議
    口頭発表（一般）

  • 片側性唇顎口蓋裂を伴う咬合不全に対し腓骨皮弁による骨再建とインプラント埋入術を行った成人男性の1例
    齊藤 泉, 渋谷恭之, 筧 康正, 明石昌也, 重田崇至, 古森孝英
    第17回顎顔面インプラント学会総会, 2013年11月, 日本語, 顎顔面インプラント学会, 東京, 国内会議
    口頭発表（一般）

  • 当科における重症性感染症例の臨床的検討
    藤林淳子, 古土井春吾, 小松原秀紀, 楠元順哉, 後藤育子, 明石昌也, 古森孝英
    第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議
    口頭発表（一般）

  • 呼吸サポートチームへの歯科介入がVAP予防に与える影響について
    後藤育子, 古土井春吾, 西井美佳, 四宮麻美, 楠元順哉, 梶 真人, 明石昌也, 渋谷恭之, 古森孝英
    第22回口腔感染症学会総会, 2013年11月, 日本語, 口腔感染症学会, 八王子, 国内会議
    口頭発表（一般）

  • 超高純度マグネシウムを用いて生体吸収性金属製骨接合プレートを作製する
    橋川 和信, 髙須 啓之, 明石 昌也, 寺師 浩人
    第31回日本頭蓋顎顔面外科学会学術集会, 2013年10月, 日本語, 日本頭蓋顎顔面外科学会学術集会, 名古屋市, 国内会議
    口頭発表（一般）

  • 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．
    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英
    第58回日本口腔外科学会総会・学術大会, 2013年10月, 日本語, 日本口腔外科学会総会・学術大会, 福岡市, 国内会議
    口頭発表（一般）

  • 口腔癌患者における胃瘻造設に関する検討―術中同時胃瘻造設について-
    米澤奈津季, 南川 勉, 明石昌也, 高橋佑輔, 長谷川巧実, 榊原晶子, 重田崇至, 渋谷恭之, 古森孝英
    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議
    口頭発表（一般）

  • 口腔癌における周術期静脈血栓塞栓症について
    筧 康正, 南川 勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英
    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議
    口頭発表（一般）

  • シスプラチン併用化学放射線療法の術後補助療法としての有効性に関する検討
    重田崇至, 南川 勉, 松井太輝, 明石昌也, 長谷川巧実, 高橋佑輔, 筧 康正, 渋谷恭之, 梅田正博, 古森孝英
    第58回日本口腔外科学会総会, 2013年10月, 日本語, 日本口腔外科学会, 福岡, 国内会議
    口頭発表（一般）

  • 再発口腔中咽頭癌に対する遊離皮弁再建に関する検討．
    明石 昌也, 橋川 和信, 寺師 浩人
    第40回日本マイクロサージャリー学会学術集会, 2013年09月, 日本語, 日本マイクロサージャリー学会学術集会, 盛岡市, 国内会議
    口頭発表（一般）

  • 再発口腔中咽頭癌に対する遊離皮弁再建における問題点-第2報-
    明石昌也, 橋川和信, 寺師浩人
    第40回日本マイクロサージェリー学会総会, 2013年09月, 日本語, 日本マイクロサージェリー学会, 岩手, 国内会議
    口頭発表（一般）

  • 舌半側切除後の遊離前腕皮弁再建症例における長期観察結果．
    明石 昌也, 橋川 和信, 榊原 晶子, 寺師 浩人
    第37回日本頭頸部癌学会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京都, 国内会議
    口頭発表（一般）

  • 再発口腔中咽頭癌に対する遊離皮弁再建における問題点
    明石 昌也, 橋川 和信, 寺師 浩人
    第37回日本頭頸部癌学会総会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京, 国内会議
    口頭発表（一般）

  • がん切除後下顎再建における再建理論「CATコンセプト」．
    橋川 和信, 明石 昌也, 野村 正, 寺師 浩人
    第37回日本頭頸部癌学会, 2013年06月, 日本語, 日本頭頸部癌学会, 東京都, 国内会議
    口頭発表（一般）

  • 造血器悪性腫瘍患者への歯科的介入に関する前向き検討
    辻 和志, 渋谷恭之, 明石昌也, 古土井春吾, 古森孝英
    第67回日本口腔科学会総会, 2013年05月, 日本語, 日本口腔科学会, 宇都宮, 国内会議
    口頭発表（一般）

  • 放射線誘発癌が疑われた口腔癌に対する遊離皮弁再建
    明石 昌也, 橋川 和信, 寺師 浩人
    第103回関西形成外科学会学術集会, 2013年03月, 日本語, 関西形成外科学会学術集会, 大阪市, 国内会議
    口頭発表（一般）

  • 舌癌180例のリンパ節転移に関する検討～健側転移について～
    松井太輝, 重田崇至, 南川 勉, 明石昌也, 高橋佑輔, 筧 康正, 古土井春吾, 渋谷恭之, 古森孝英
    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌術後局所再発症例に関する検討
    高橋佑輔, 南川 勉, 筧 康正, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 渋谷恭之, 古森孝英
    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議
    口頭発表（一般）

  • 口腔扁平上皮癌T4症例に対する手術療法の治療成績
    筧 康正, 南川 勉, 高橋佑輔, 松井太輝, 榊原晶子, 明石昌也, 重田崇至, 古土井春吾, 渋谷恭之, 古森孝英
    第31回日本口腔腫瘍学会総会, 2013年01月, 日本語, 日本口腔腫瘍学会, 東京, 国内会議
    口頭発表（一般）

  • Facial artery musculomucosal flapにより口腔上顎洞瘻孔を治療した1例
    明石 昌也, 橋川 和信, 大澤 沙由理, 寺師 浩人
    第30回日本頭蓋顎顔面外科学会学術集会, 2012年11月, 日本語, 日本頭蓋顎顔面外科学会, 豊中, 国内会議
    口頭発表（一般）

  • 遊離腓骨皮弁移植におけるMR Angiographyと超音波検査による下肢血管解剖の術前評価
    明石 昌也, 橋川 和信, 榊原 晶子, 長谷川 巧実, 重田 崇至, 南川 勉, 古土井 春吾, 渋谷 恭之, 古森 孝英
    第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議
    口頭発表（一般）

  • 下顎骨区域欠損に対する再建理論「CATコンセプト」の実践
    橋川 和信, 明石 昌也, 榊原 晶子
    第57回日本口腔外科学会総会・学術大会, 2012年10月, 日本語, 日本口腔外科学会, 横浜, 国内会議
    口頭発表（一般）

  • 外傷後に生じたclaw toe変形に対し長趾屈筋移行術を施行した1例
    髙須 啓之, 橋川 和信, 明石 昌也, 寺師 浩人
    第101回日本形成外科学会関西支部学術集会, 2012年07月, 日本語, 日本形成外科学会関西支部, 大阪, 国内会議
    口頭発表（一般）

  • 金属製再建プレートによる下顎骨再建後の合併症について－下顎骨硬性再建に関する一考察
    明石 昌也, 橋川 和信, 榊原 晶子, 榊原 俊介, 横尾 聡, 寺師 浩人, 田原 真也
    第55回日本形成外科学会総会・学術集会, 2012年04月, 日本語, 日本形成外科学会, 東京, 国内会議
    口頭発表（一般）

  • プレート破折後に遊離腓骨皮弁で下顎骨再建を行った1例
    明石 昌也, 橋川 和信, 田原 真也
    第99回日本形成外科学会 関西支部学術集会, 2011年12月, 日本語, 日本形成外科学会, 京都, 国内会議
    口頭発表（一般）

  • Protective immune response by intranasal immunization with split-virion influenza A vaccine with adjuvant and whole-viron influenza A vaccine
    Okamoto S, Matsuoka S, Yamada H, Gomi Y, Okuno Y, Akagi T, Akashi M, Mori Y, Yamanishi K
    Cell Symposia: Influenza - Translating basic insights, 2010年12月, 英語, Elsevier(Cell Press), Washington DC, アメリカ合衆国, 国際会議
    口頭発表（一般）

  • Impaired stratum corneum formation in claudin-1-deficient mice with defect in tight junction function
    Sugawara T, Akashi M, Yuki T, Nakagawa N, Sakai S, Sugiyama Y, Inoue S, Furuse M
    第35回日本研究皮膚科学会総会, 2010年12月, 英語, 日本研究皮膚科学会, 和歌山, 国内会議
    口頭発表（一般）

  • 口腔癌手術における嚥下改善手術に関する臨床的検討．
    明石 昌也, 南川 勉, 高橋英哲, 小國 晶子, 橋川 和信, 古土井 春吾, 渋谷 恭之, 梅田 正博, 古森孝英
    第55回日本口腔外科学会総会, 2010年10月, 日本語, 日本口腔外科学会, 千葉, 国内会議
    口頭発表（一般）

■ 共同研究・競争的資金等の研究課題
  • 好中球に着眼したシェーグレン症候群の新規病理分類提案と治療薬探索
    後藤 育子, 西村 啓佑, 重岡 学, 木本 明, 明石 昌也, 明石 健吾, 筧 康正
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日

  • 顎骨壊死に対する腐骨分離促進療法の探索
    明石 昌也, 重岡 学, 有本 智美, 木本 明, 長谷川 巧実, 筧 康正
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月01日 - 2026年03月31日

  • ミトコンドリアの正常化と癌関連線維芽細胞の再教育を目指した新規口腔癌治療法の開発
    長谷川 巧実, 榊原 晶子, 明石 昌也, 武田 大介
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2022年04月01日 - 2026年03月31日

  • 統合オミックス解析による口腔がん制御機構の解明と創薬標的の網羅的探索
    木本 明, 明石 昌也, 榎本 由依
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2021年04月01日 - 2024年03月31日
    口腔がんの大部分は扁平上皮癌であり、標準的治療は手術とされている。また、補助療法として放射線治療、化学療法が併用されることが多いが、進行がんに対しては予後が悪く、制御が可能であった場合でも患者自身のQOLを著しく低下させる。そのため、根治治療を目的としながらも、可能な限り機能を温存することも口腔がんにおいては重要である。現在、口腔がんに対する化学療法は、シスプラチン(CDDP)や5-FU、ドセタキセルが使用されている。しかし、進行がんを制御するまでは至っておらず、副作用も多い。本研究では、統合オミックス解析を行い、口腔がんに特異的な代謝経路を探索する。また、それに関わる代謝酵素のうち、がんの増殖の制御に関わるものを導き出し、その阻害剤の効果を検討することで、将来的な口腔がんの新たな治療薬の開発をめざす。 今年度は、まずヒト由来口腔がん細胞株（OSC-19、HSC-3）のガスクロマトグラフィー質量分析を実施した。また、口腔がん患者の血漿メタボローム解析を実施し、得られたデータを統計ソフトを用いて多変量解析することで、口腔がん患者に特異的な代謝物の変動を探索している。次に、ヒト由来口腔がん細胞株と血漿メタボローム解析の結果と比較することで、特に著明な変化を示す代謝経路の探索を開始している。今後は、これらに加え、口腔がん生体材料のメタボローム解析を実施することで、さらに口腔がん特異的な代謝経路を絞っていく予定である。

  • 食品基礎科学を応用した新規咀嚼機能評価法の開発とオーラルフレイルへの波及効果
    渋谷 恭之, 高岡 素子, 桐田 忠昭, 梅田 正博, 栗田 浩, 明石 昌也, 前田 道徳
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 名古屋市立大学, 2020年04月01日 - 2024年03月31日
    総義歯装着者や口腔外科等で顎骨切除した患者等に対して咀嚼機能を評価することは、総義歯の調整を行ったり、術後の経過を評価したり、術後の食事ケアの内容を決定したりするうえで極めて重要である。また、オーラルフレイルのある高齢者に提供する栄養学的に適切な食事メニューを決めるためにも、咀嚼機能の評価は必要である。従来の咀嚼機能評価としては、佐藤らの総義歯咀嚼能率判定表が良く用いられている。この判定法は、総義歯装着者に対して100種類の食品について咀嚼に関するアンケート調査を行った結果に基づき、各食品の咀嚼難易度を咀嚼指数を定めた表によって咀嚼機能が評価される。このため、各食材を用いることにより簡便に咀嚼機能を評価することができる。しかしながら、総義歯装着者に対するアンケートという主観的な調査方法に基づいているため客観性に乏しく、咀嚼難易度の判定基準が不明確であるという問題があった。また、食品の調理方法や形態についても定められておらず、曖昧であるという問題もあった。さらには、食生活の変化により、現代ではあまり食されていないという食品も多く含まれているという問題があった。そこで総義歯咀嚼能率判定表に示された数多くの食材について物理的特性を測定機器を用いて解析し、総義歯咀嚼能率判定表における咀嚼指数との相関関係を調べた。その結果、測定値から得られた５つのパラメータ（硬さ、粘着性、付着性、凝集性及び咀嚼性）のうち咀嚼性のみが咀嚼指数との間で有意な相関関係を示すことを見出した。さらに、咀嚼性を決定するパラメータのうち、硬さ及び凝集性の値によってクラスター分析を行ったところ、判定基準が明確で客観性を有するいくつかのクラスターに分類できることを明らかとなった。これを指標に試料となるグミを開発中である。

  • 生体適合性酸化チタンを用いた歯周病・口腔がん治療システムの構築
    荻野 千秋, 明石 昌也, 西村 勇哉, 筧 康正
    日本学術振興会, 科学研究費助成事業, 挑戦的研究(萌芽), 神戸大学, 2021年07月09日 - 2023年03月31日
    近年、口腔がんと口腔細菌叢（歯周病菌叢）との関連を示唆する科学的根拠が報告され、注目を集めている(Scientific Reports, 7, 11773 (2017)など)。本研究の目的は、口腔がん、および歯周病の原因となる歯周病菌叢に対して、同一手法で治療する方法を提案する。具体的には、我々が構築した「過酸化チタン粒子」(TiOx)の酸化力、およびその放射線照射法の適用性を適用・検証する事である。本研究の目的は、「過酸化チタン／放射線」照射法を、口腔がんや歯周病菌叢へと適用し、少ない放射線量においてもがん細胞、および細菌損傷に適用可能か検証を行う事である。この研究目的の遂行のために、以下に掲げる2つの項目について検討を行った。 [1] 植物成分でコーティングされた過酸化チタン粒子の開発：TiO2 NPs(石原産業)を元に、RutinG-TiOx NPsと、PAA-TiOx NPsにRutinGを添加したRutinG+PAA-TiOx NPsを作製した。各修飾粒子をUV-visとFT-IRによって、RuitnGのコーティングを確認した。PAA-TiOx NPsと比較したRutinG-TiOxの放射線増感効果の検証するために、H2O2の吸脱着量を化学蛍光法によって定量した。PAA-TiOx及びRutinG-TiOx NPsから219.8, 39.5 micro-mol/gのH2O2が脱着した。この結果より、RutinG-TiOxはPAA-TiOxほどではないがH2O2徐放性を持つことが示唆された。 [2] 過酸化チタン/放射線による治療：in vitroでの放射線増感効果を検証するためコロニーアッセイを行った。5Gyを照射した場合、RutinG-TiOx NPsにもPAA-TiOx NPsと同様に放射線増感効果を持つことが示された。

  • 血管・リンパ管新生に着眼した歯性感染症－顎骨骨髄炎移行メカニズム解明と治療法探索
    明石 昌也, 木本 明, 長谷川 巧実, 筧 康正
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2023年03月31日
    骨粗鬆症などに対し用いられる骨吸収抑制薬や、口腔癌に対し施行される放射線照射等の医療行為が素因となる顎骨骨髄炎は、近年患者数の増加に伴い顎口腔外科領域において最も新たな治療法開発が期待される難治性疾患の一つである。本研究の目的は、近年感染の進展にも関与していることが明らかとなりつつある血管・リンパ管新生をターゲットとし、歯性感染症－顎骨骨髄炎移行メカニズムを解明することである。 研究の端緒として、まず血管新生のマーカーとなりうる分子の検討を行なった。近年動脈硬化や高血圧、腫瘍の増大における病的な状態における血管新生に関与している可能性が示唆されている血管内皮細胞間接着複合体構成分子に注目した。この分子についてはマウスやヒト培養細胞を用いた研究はこれまでに行われてきたが、ヒトの組織内での発現や局在部位を確認した報告は稀少であった。当該年度の研究結果より、この分子がヒトの組織内でも特に非炎症部位の血管に比べ炎症部位の微小血管等に発現が強く、病的な血管のマーカーとなり得る可能性が示唆された。

  • 長谷川 巧実, 明石 昌也, 武田 大介
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2018年04月01日 - 2022年03月31日
    近年、局所的に炭酸ガスを効率的に吸収させることのできる炭酸ガス投与法を開発し、それを扁平上皮癌に応用した。その結果、腫瘍内の低酸素環境改善やミトコンドリア経路のアポトーシスの活性化によって癌の増殖抑制が起こることを発見した。さらに、上皮間葉移行(EMT)低下によるリンパ節転移の抑制がおこることを確認した。本研究の目的は、この局所的炭酸ガス投与を応用し、①腫瘍免疫抑制と治療抵抗性に対する改善効果と、②既存治療の副作用軽減効果を調査し、低リスク・低コストの新規口腔癌治療の開発を目指すことである。in vivoの研究において、5週齢のヌードマウス背部にHSC-3を皮下移植し、各治療法別(control群、RT群、CDDP群、CO2群、RT+CO2群、CDDP＋CO2群)に検討した。局所的炭酸ガス投与は、われわれが過去に報告した方法で行った。各群より腫瘍を採取し、RNAを回収し、Real-time PCR法で計測した。RT+CO2群で、RT群に比較し、腫瘍の増加抑制効果を認め、低酸素誘導因子(HIF-1α)の減少、アポトーシス関連因子(PARP, Caspase3, 8, 9)の増加、さらに活性酸素関連因子(ROMO-1)の増加を認めた。また、骨髄抑制の副作用はRT単独群で、もっとも増加し、RT＋CO2群である併用群ではむしろ改善傾向であった。また、抗癌剤(CDDP)との検討において、NF-kB、MDR1、CD44では、Control群に比較し、CDDP群では変化なく、CO2群やCDDP+CO2群において、減少していた。したがって、経皮的炭酸ガス投与は口腔扁平上皮癌に対し腫瘍内低酸素環境を改善し、抗癌剤(CDDP)および放射線治療と併用することで腫瘍縮小効果の増大が期待できることや副作用軽減効果があることが示唆された。腫瘍免疫抑制関連因子については現在検討中である。
    競争的資金

  • メタボローム解析を用いたARONJに対する新規LED治療の開発
    鈴木 泰明, 古森 孝英, 明石 昌也, 近津 大地, 木本 明
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2017年04月01日 - 2021年03月31日
    我が国で現在推奨されている骨吸収抑制薬関連顎骨壊死（Anti-resorptive agents-related osteonecrosis of the jaw: ARONJ）の治療は、科学的エビデンスに基づくものではなく、これまでの症例の集積と専門家の意見の集約にすぎない。国外では以前より「低反応レベルレーザー治療（Low reactive Level LaserTherapy: LLLT）」が適応され、文献での有用性がシステマティックに検証されている。日本口腔外科学会を含む関連6学会で更新された『ポジションペーパー2016』でも今後明らかにすべき検討課題とされ、我が国でもLLLT研究への積極的な取組みが急務である。このエビデンス獲得のため我々はメタボローム解析の適用を着想した。近年、LLLTはレーザー以外にLED等の光源も含め「低反応レベル光治療」として認知されつつあり、LED光のARONJに対する有効性を見出し、レーザーよりも安価で簡便なLEDによる新規のARONJ治療機器開発へつなげることを目指すべく本研究を開始した。 作年度までに、培養口腔内常在菌に対するLED照射効果の解析を行った。BRONJ発症への関与が報告されているレンサ球菌と放線菌を対象に、405、630、950nmの波長で照射を行い、LED照射群とLED非照射群（コントロール群）の生存細菌数を比較した。今年度は、BP 製剤を添加したヒト培養口腔扁平上皮細胞（HNOKｓ）と骨髄造血幹細胞（CD34+)に関して、LED光照射を行い、経時的な比較検討を行う予定であったが、予備実験の段階のため、解析に至っていない。今後、さらに条件を整えた上で進めていく予定である。

  • 古土井 春吾, 古森 孝英, 明石 昌也, 筧 康正
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2017年04月01日 - 2020年03月31日
    骨格筋機能的磁気共鳴画像(muscle functional Magnetic Resonance Image:mfMRI)の機能画像を用いて、健常被験者で安静時と咀嚼時の咀嚼筋について運動前後におけるT2値の変化(ΔT2)を測定したところ、咀嚼時の両側咬筋のΔT2上昇が確認された。咀嚼筋の形態的標準化が可能となった。続いて、口腔癌再建患者にmfMRIを応用すると、健側は術前と同様の形態と筋量が維持されており、咀嚼力は維持されていると考えられた。一方、患側は手術により切除されていることから、形態は変化して筋量は縮小しており、咀嚼力は低下していることが示唆された。
    競争的資金

  • 鈴木 泰明
    学術研究助成基金助成金／基盤研究(C), 2017年04月 - 2020年03月
    競争的資金

  • 明石 昌也
    日本学術振興会, 科学研究費助成事業 若手研究(B), 若手研究(B), 神戸大学, 2015年04月01日 - 2019年03月31日, 研究代表者
    癌の制御とリンパ管との関わりについて理解を深めるため、リンパ管内皮細胞に対する放射線照射の影響を、細胞間接着複合体の形態（morphology of cell junctions）や強度（integrity）、透過性（permeability）、直線性（linearity）を指標に評価した。その結果、放射線照射の影響によりリンパ管内皮細胞の変化が明らかとなり、癌のリンパ節転移や放射線照射後のリンパ浮腫等の合併症の発症メカニズムへの理解に寄与することが出来た。
    競争的資金

  • 明石 昌也
    日本学術振興会, 科学研究費助成事業 若手研究(B), 若手研究(B), 神戸大学, 2011年04月28日 - 2015年03月31日, 研究代表者
    リンパ管内皮細胞は正常な機能を維持するため細胞間結合により調節されている。本研究の目的の一つは、リンパ管内皮細胞の細胞間結合の特質性を明らかにこと、炎症性サイトカインTNF-αの細胞間結合に対する影響を解析することであった。 培養ヒト皮膚リンパ管内皮細胞（HDLEC）を密着結合マーカー、接着結合マーカー（VE-cadherin）で免疫染色し、TNF-α処理HDLECで同じ免疫染色と経内皮電気抵抗値を測定した。 その結果、野生型HDLECにおいて連続的・非連続的細胞間結合が混在していること、TNF-αは野生型における細胞間結合を変化させ、リンパ管内皮細胞のバリアに影響を与えていることが示唆された。
    競争的資金

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