研究活動情報

• Global Trends in the Value of Author Order Across Medical Publications: A Cross-Sectional Bibliometric Study

  Hidenori Hashimoto, Miwa Sekine, Yuji Nishizaki, David Aune, Atsushi Mizuno, Yasuhiro Homma, Yasuhiko Kiyama, Shoji Sanada, Shigeki Aoki

  2025年02月, CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 18(2) (2), 英語

  研究論文（学術雑誌）


• From Optional to Default ― Enhancing Article Viewership Through X (Formerly Twitter) Posting ―

  Atsushi Mizuno, Daisuke Yoneoka, Takuya Kishi, Kenya Kusunose, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Masataka Sata, Toshihisa Anzai, Koichi Node

  BACKGROUND: The influence of a change to a default X summary posting strategy on article viewership has not been investigated. METHODS AND RESULTS: We conducted a retrospective analysis of X-posting rates and journal viewership data for both the Circulation Journal and Circulation Reports from April 2022 to September 2023. Following protocol modifications in March 2023, there was a notable increase in the X-posting rate from 12.4% to 61.7%, along with an uptick in median access counts to article pages within 30 days, from 175 to 231.5. CONCLUSIONS: Trend analysis of journal viewership after a default X-posting strategy revealed an increase in viewer access.

  Japanese Circulation Society, 2024年08月, Circulation Reports, 6(9) (9), 389 - 394, 英語, 国内誌

  研究論文（学術雑誌）


• Impact of Tweet Content on the Number of Retweets ― “Tweet the Meeting 2022” ―

  Takahiro Suzuki, Atsushi Mizuno, Takuya Kishi, Jeffrey Rewley, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Koichi Node

  Background: Previous research has investigated the effectiveness of the "Tweet the Meeting" campaign, but the relationship between tweet content and the number of retweets has not been fully evaluated. Methods and Results: We analyzed the number of tweets and retweets during the Japanese Circulation Society's 2022 annual meeting. The ambassador group had significantly more session- and symposium-related tweets than the non-ambassador group (P<0.001), associated with the nubmer of retweets. Symposium-related tweets with figures generated more retweets than those without figures (mean [±SD] 3.47±3.31 vs. 2.48±1.94 retweets per tweet, respectively; P=0.001). Conclusions: The study revealed that official meeting-designated Twitter ambassadors disseminate more educational content than non-ambassadors, and generated more retweets.

  Japanese Circulation Society, 2023年06月, Circulation Reports, 5(7) (7), 306 - 310, 英語, 国内誌

  研究論文（学術雑誌）


• Understanding International Differences in Academic Author Order in General Medicine Publications.

  Miwa Sekine, Yasuhiko Kiyama, Rieko Ueda, David Aune, Shoji Sanada, Yuji Nishizaki

  OBJECTIVES: With increasing multinational research in general medicine, the lack of a standardized policy regarding the order of author bylines can create conflict and misunderstanding due to different practices worldwide. METHODS: We examined publicly available data from websites such as Journal Citation Reports and Web of Science, focusing on original articles published in the "Medicine, General, & Internal" category in 2020. Of 169 journals in the "Medicine, General, & Internal" category, we selected the ten countries with the highest number of publications and then examined the position of the corresponding author in the author byline as an indicator of the author in charge since corresponding authors are considered to have contributed the most. RESULTS: The top ten countries with the highest publications are the USA, China, Germany, England, Japan, France, Italy, Canada, India, and Australia. The results demonstrated that the percentage of the second author being the corresponding author was the highest in Japan compared to other countries. This percentage was 25 times higher in Japan than in the USA. CONCLUSIONS: Understanding international differences regarding author order would facilitate smoother collaboration.

  2023年, Juntendo Iji zasshi = Juntendo medical journal, 69(5) (5), 405 - 408, 英語, 国内誌

  研究論文（学術雑誌）


• A cross-sectional survey on principal investigators' clinical research knowledge in Japan.

  Miwa Sekine, Koshi Kataoka, Yuji Nishizaki, Kotone Matsuyama, Toshiaki Otsuka, Kensuke Sato, Mayumi Idei, Shoji Sanada

  Principal investigators (PIs) play a key role in clinical research, and must thus understand the role of clinical research support staff to conduct successful and appropriate clinical research. This study evaluates clinical research capabilities by examining the clinical research knowledge of PIs and clinical research support staff. The participants of this cross-sectional study were academic researchers and clinical research support staff from Japanese universities and research institutions. The participants comprised of 54 respondents, among whom 36 were PIs (physicians) and 18 were clinical research support staff. A self-administered electronic survey was created and evaluated by experts, with 50 knowledge items. Mann-Whitney U tests were used to determine the significance of the differences in knowledge between clinical research support staff and PIs. We compared the correct answer rate of clinical research support staff and PIs for each knowledge category and observed that the clinical research support staff scored significantly higher than the PIs in all aspects of clinical research knowledge sections, including total score. Our findings showed that PIs did not have the same amount of clinical research knowledge as the clinical research support staff. Clinical research knowledge is essential for investigators, especially PIs, to protect patients and promote medical breakthroughs. Thus, more accessible clinical research education and mandatory knowledge testing will allow PIs to lead successful clinical research and further the level of medical research in Japan.

  2022年11月, Clinical and translational science, 16(3) (3), 459 - 466, 英語, 国際誌

  研究論文（学術雑誌）


• Impact of Tweeting Summaries by the Japanese Circulation Society Official Account on Article Viewership ― Pilot Trial ―

  Atsushi Mizuno, Kenya Kusunose, Takuya Kishi, Jeffrey Rewley, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Daisuke Yoneoka, Masataka Sata, Toshihisa Anzai, Koichi Node

  BACKGROUND: The impact of promotional tweets from the official journal account (forCirculation JournalandCirculation Reports) on article viewership has not been thoroughly evaluated.Methods and Results:We retrospectively collected journal viewership data forCirculation JournalandCirculation Reportsfrom March 2021 to August 2021. We compared viewership between articles with (n=15) and without (n=250) tweets. After 1 : 4 propensity score matching (15 tweeted articles and 60 non-tweeted matched controls), journal viewership metrics within 7 days of the tweeting date (and the hypothetical tweeting date), was larger in tweeted articles than non-tweeted articles (median [interquartile range] Abstract page views 89 [60-104] vs. 18 [8-41]). CONCLUSIONS: This pilot study suggests a positive relationship between journal-posted promotional tweets and article viewership.

  Japanese Circulation Society, 2022年03月, Circulation Journal, 86(4) (4), 715 - 720, 英語, 国内誌

  研究論文（学術雑誌）


• The association between research funding status and clinical research papers' citation impact in Japan: A cross-sectional bibliometric study.

  Fumito Morisawa, Yuji Nishizaki, Patrick Devos, Naotake Yanagisawa, Kotone Matsuyama, Yasuhiro Homma, Rieko Ueda, Miwa Sekine, Hiroyuki Daida, Tohru Minamino, Shoji Sanada

  INTRODUCTION: Studies have not sufficiently clarified the differences in citation impact between funded and non-funded clinical research papers. Hence, this study seeks to evaluate the relation between research funding status and clinical research papers' citation impact in different research fields using multiple evaluation indices. METHODS: In this cross-sectional bibliometric study, clinical research papers published by core clinical research hospitals in Japan were compared retrospectively in terms of times cited (TC), category normalized citation impact (CNCI), citation percentile (CP), journal impact factor (JIF), the Software to Identify, Manage, and Analyze Scientific Publications (SIGAPS) category, and whether they were the funded clinical research. The association between research funding status or the SIGAPS category and CNCI ≥ 2 was analyzed using logistic regression analysis. RESULTS: 11 core clinical research hospitals published 553 clinical research papers, of which 120 were non-funded and 433 were funded (public institution-funded and industry-funded). The study found that funded clinical research papers (public institution-funded and industry-funded) had significantly higher TC, CNCI, CP, and JIF than non-funded ones [TC: 8 (3-17) vs. 14 (8-31), p < 0.001; CNCI: 0.53 (0.19-0.97) vs. 0.87 (0.45-1.85), p < 0.001; CP: 51.9 (24.48-70.42) vs. 66.7 (40.53-88.01), p < 0.001; JIF: 2.59 (1.90-3.84) vs. 2.93 (2.09-4.20) p = 0.008], while the proportion of A or B rank clinical research papers of the SIGAPS category was not significantly different between the two groups (30.0 vs. 34.9%, p = 0.318). In the logistic regression analysis, having a CNCI ≥ 2 was significantly associated with research funding (public institution-funded and industry-funded) and publication in A or B rank journals of the SIGAPS category [research funding: Estimate 2.169, 95% confidence interval (CI) 1.153-4.083, p = 0.016; SIGAPS category A/B: Estimate 6.126, 95% CI 3.889-9.651, p < 0.001]. CONCLUSION: Analysis via multiple indicators including CNCI and the SIGAPS category, which allows for a comparison of the papers' citation impact in different research fields, found a positive relation between research funding status and the citation impact of clinical research papers.

  2022年, Frontiers in medicine, 9, 978174 - 978174, 英語, 国際誌

  [査読有り]

  研究論文（学術雑誌）


• 多職種協調型ワークショップの成果物としてのプロトコル素案作成に関する考察

  大谷直由, 塩崎正幸, 久本佳奈, 水城忠貴, 荒木浩之, 田尻涼, 稲田実枝子, 肥田典子, 有田悦子, 松野康子, 真田昌爾

  The quality of clinical research design can be improved in a way by involving support-professional in charge of Quality Control (QC) and Quality Assurance (QA) since the initial stage of the research. The second way is to introduce the concept of Quality by Design (QbD) to propose research designs in view of the future and cooperate with researchers. Thus, in addition to strengthen the support function for the construction of research plan designs, each support-professional must collaborate with researchers since the early planning stage to formulate research plans, thereby ensuring the quality of the research process and deliverables. We participated in a multidisciplinary collaborative workshop. The purpose of this workshop was “creation of an efficient multi-professional collaborative educational program and development of an effective multi-professional collaborative clinical study workshop utilizing the linkage of occupation-specific and cross-cutting core competencies (Principal Investigator: Shoji Sanada)” in the “investigation and business summary of the multidisciplinary workshop” as the 2nd year of Reiwa Central Institutional Review Board Promotion project in Japan Agency for Medical Research and Development (AMED). We had brushed up the protocol synopsis in this multi-professional collaborative workshop, further revised it, and made a draft protocol with the workshop members. We expect that this study will help to build a multidisciplinary educational program in this project.

  一般社団法人 日本臨床薬理学会, 2021年12月, 臨床薬理, 52(6) (6), 165 - 173, 日本語

  [査読有り]


• The relationship between contributions of authors and author order.

  Rieko Ueda, Yuji Nishizaki, Yasuhiro Homma, Patrick Devos, Shoji Sanada

  2021年11月, Journal of general and family medicine, 22(6) (6), 361 - 362, 英語, 国内誌

  研究論文（学術雑誌）


• Relationship Between Official Twitter Ambassadors and the Number of Retweets in the Annual Congress - "Tweet the Meeting".

  Atsushi Mizuno, Jeffrey Rewley, Takuya Kishi, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Koichi Node

  Background: The relationship between Twitter ambassadors and retweets has not been fully evaluated for "tweet the meeting" activity. Methods and Results: We collected data on the number of tweets and retweets during the Japanese Circulation Society's (JCS) annual meetings in 2019, 2020, and 2021. After adjustment, JCS Twitter Ambassadors, selected by the JCS to increase the meeting's visibility, increased the total number of retweets by 9%. Conclusions: This is the first report on the numerical relationship between JCS Twitter Ambassadors and the total number of retweets during an annual congress. Original tweets by JCS Twitter Ambassadors increased the number of retweets, but retweets by influencers were more effective at stimulating social media engagement.

  2021年07月, Circulation reports, 3(7) (7), 414 - 418, 英語, 国内誌

  研究論文（学術雑誌）


• Performance Index for Types of Clinical Research Support Service Providers for Academic Research Organizations in Japan: A Cross-Sectional Survey.

  Keiko Ueda, Naoto Uemura, Kotone Matsuyama, Yuji Nishizaki, Nanae Tanemura, Kento Asano, Yuki Otsuka, Naotake Yanagisawa, Toshiaki Otsuka, Shinji Yasuno, Rieko Ueda, Yumiko Seo, Hironori Nakagami, Shoji Sanada

  2021年03月, Clinical and translational science, 14(2) (2), 745 - 755, 英語, 国際誌

  [査読有り]

  研究論文（学術雑誌）


• Cardiology Department Practices in the First Wave of the Coronavirus Disease Pandemic - A Nationwide Survey in Japan by the Japanese Circulation Society.

  Atsushi Mizuno, Chisa Matsumoto, Daisuke Yoneoka, Takuya Kishi, Mari Ishida, Shoji Sanada, Memori Fukuda, Yoshihiko Saito, Keiko Yamauchi-Takihara, Hiroyuki Tsutsui, Keiichi Fukuda, Issei Komuro, Koichi Node

  Background: From the early phase of the Coronavirus disease-2019 (COVID-19) pandemic, cardiologists have paid attention not only to COVID-19-associated cardiovascular sequelae, but also to treatment strategies for rescheduling non-urgent procedures. The chief objective of this study was to explore confirmed COVID-19 cardiology case experiences and departmental policies, and their regional heterogeneity in Japan. Methods and Results: We performed a retrospective analysis of a nationwide survey performed by the Japanese Circulation Society on April 13, 2020. The questionnaire included cardiology department experience with confirmed COVID-19 cases and restriction policies, and was sent to 1,360 certified cardiology training hospitals. Descriptive analysis and spatial autocorrelation analysis of each response were performed to reveal the heterogeneity of departmental policies. The response rate was 56.8% (773 replies). Only 16% of all responding hospitals experienced a COVID-19 cardiology case. High-risk procedures were restricted in more than one-fifth of hospitals, including transesophageal echocardiography (34.9%) and scheduled catheterization (39.5%). The presence of a cardiologist in the COVID-19 team, the number of board-certified cardiologists, any medical resource shortage and a state of emergency were positively correlated with any type of restriction. Conclusions: We found both low clinical case experiences with COVID-19 and restrictions of cardiovascular procedures during the first COVID-19 wave in Japan. Restrictions arising as a result of COVID-19 were affected by hospital- and country-level variables, such as a state of emergency.

  2021年02月, Circulation reports, 3(3) (3), 137 - 141, 英語, 国内誌

  研究論文（学術雑誌）


• Cardiology Department Policy in Japan After Coronavirus Disease-2019 (COVID-19) - Descriptive Summary of 2nd Nationwide Survey by the Japanese Circulation Society.

  Atsushi Mizuno, Chisa Matsumoto, Takuya Kishi, Mari Ishida, Shoji Sanada, Memori Fukuda, Issei Komuro, Kenichi Hirata, Koichi Node

  Background: Cardiovascular department restriction policies on procedures resulting from the COVID-19 pandemic have not been fully evaluated. Methods and Results: We performed a retrospective analysis of a nationwide survey performed by the Japanese Circulation Society in August 2020. The total response rate was 48.9% (651/1,331). The rate of restriction of cardiovascular procedures peaked in April. Exacerbations of heart failure due to hospital restrictions were noted in 43.8% of departments. Conclusions: Many departments restricted their cardiological procedures, and this rate changed according to the pandemic situation. The exacerbation of cardiovascular disease resulting from pandemic restrictions should not be ignored.

  2021年01月, Circulation reports, 3(2) (2), 100 - 104, 英語, 国内誌

  研究論文（学術雑誌）


• Factors Associated With the Acceleration of Patient Enrollment in Clinical Studies: A Cross-Sectional Study.

  Rieko Ueda, Yuji Nishizaki, Shuko Nojiri, Hiroshi Iwata, Katsumi Miyauchi, Kotone Matsuyama, Shoji Sanada, Tohru Minamino, Hiroyuki Daida

  Under-recruitment in clinical trials is an issue worldwide. If the number of patients enrolled is lower than expected, based on the required sample size, then the reliability of the study results and their validation tend to be impaired. The current study therefore evaluated factors associated with accelerating patient enrollment using data from an ongoing multicenter prospective cohort study. The researchers encouraged research institutions to accelerate patient enrollment via e-mail, newsletters, telephone calls, and site visits. We analyzed the relationship between several potential factors associated with acceleration of patient enrollment including site visits and patient enrollment in a real clinical study. Data were collected from 106 research institutions that participated in a multicenter prospective cohort study. Results showed that the following parameters differed in terms of patient enrollment and non-enrollment: urban area (47.2 vs. 67.6%, p = 0.04), clinical research coordinator (CRC) participation in data input to electronic data capture (EDC) (41.7 vs. 11.8%, p < 0.01), and site visit (38.9 vs. 11.8%, p < 0.01). A multivariate analysis revealed that patient enrollment was significantly associated with urban area (odds ratio [OR] 0.33, 95% confidence interval [CI] 0.12-0.86, p = 0.02), CRC participation in data input to EDC (OR 5.02; 95% CI 1.49-16.8; p < 0.01), and site visit (OR 4.54, 95% CI 1.31-15.7, p = 0.01). In conclusion, site visits and CRC participation in data input to EDC had a significant effect on patient enrollment promotion. Moreover, hospitals in rural areas were more effective in promoting patient enrollment than those in urban areas.

  2021年, Frontiers in pharmacology, 12, 753067 - 753067, 英語, 国際誌

  [査読有り]

  研究論文（学術雑誌）


• Recommendations for Maintaining the Cardiovascular Care System Under the Conditions of the COVID-19 Pandemic - 1st Edition, April 2020.

  Takuya Kishi, Atsushi Mizuno, Mari Ishida, Chisa Matsumoto, Memori Fukuda, Shoji Sanada, Naoya Itoh, Hideaki Oka, Koichi Node, Issei Komuro

  BACKGROUND: The Japanese Circulation Society proposes recommendations for all healthcare professionals involved in cardiovascular medicine to protect them from infection and ensure that seriously ill patients requiring urgent care receive proper treatment.Methods and Results:Patients are divided into "Positive or suspected coronavirus disease 2019 (COVID-19)" and "All others". Furthermore, tests and treatments are divided into emergency or standby. For each category, we propose recommendations. CONCLUSIONS: To maintain the cardiovascular care system, The Japanese Circulation Society recommends completely preventing nosocomial COVID-19 infections, ensuring adequate PPE necessary for healthcare personnel, and learning and implementing standard precautions.

  2020年10月, Circulation journal : official journal of the Japanese Circulation Society, 84(11) (11), 2023 - 2026, 英語, 国内誌

  [査読有り]

  研究論文（学術雑誌）


• Two-Year Experience in "Tweeting the Meeting" During the Scientific Sessions - Rapid Report From the Japanese Circulation Society.

  Atsushi Mizuno, Takuya Kishi, Chisa Matsumoto, Mari Ishida, Shoji Sanada, Memori Fukuda, Yuki Sahashi, Tadafumi Sugimoto, Miki Hirano, Yusuke Yoshikawa, Erika Yamamoto, Takeshi Kimura, Koichi Node

  Background: Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. The aim of this study is to reveal the twitter usage in the annual congress of the Japanese Cirsulation Society. Methods and Results: We compared the total number of tweets during the Japanese Circulation Society's annual meetings in 2019 and 2020. The total number of tweets increased from 7,587 in 2019 to 23,867 in 2020. Most tweets were retweets (>70%), and approximately half of Twitter users tweeted only once. Conclusions: Twitter usage during the Japanese Circulation Society's annual meeting increased from 2019 to 2020, and a large number of tweets were from Twitter ambassadors of the Japanese Circulation Society. However, further evaluation is needed, with future studies investigating the usefulness of this platform.

  2020年09月, Circulation reports, 2(11) (11), 691 - 694, 英語, 国内誌

  研究論文（学術雑誌）


• Differences in author ranking: Development of SIGAPS scoring system for Japanese version.

  Yuji Nishizaki, Yasuhiro Homma, Rieko Ueda, Patrick Devos, Shoji Sanada

  2020年09月, Journal of general and family medicine, 21(5) (5), 208 - 209, 英語, 国内誌

  [査読有り]

  研究論文（学術雑誌）


• Coronavirus Disease 2019 (COVID-19) Information for Cardiologists - Systematic Literature Review and Additional Analysis.

  Tadafumi Sugimoto, Atsushi Mizuno, Takuya Kishi, Naoya Ito, Chisa Matsumoto, Memori Fukuda, Nobuyuki Kagiyama, Tatsuhiro Shibata, Takashi Ohmori, Shogo Oishi, Jun Fuse, Keisuke Kida, Fujimi Kawai, Mari Ishida, Shoji Sanada, Issei Komuro, Koichi Node

  BACKGROUND: Despite the rapidly increasing attention being given to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, more commonly known as coronavirus disease 2019 (COVID-19), the relationship between cardiovascular disease and COVID-19 has not been fully described. METHODS AND RESULTS: A systematic review was undertaken to summarize the important aspects of COVID-19 for cardiologists. Protection both for patients and healthcare providers, indication for treatments, collaboration with other departments and hospitals, and regular update of information are essentials to front COVID-19 patients. CONCLUSIONS: Because the chief manifestations of COVID-19 infection are respiratory and acute respiratory distress syndrome, cardiologists do not see infected patients directly. Cardiologists need to be better prepared regarding standard disinfection procedures, and be aware of the indications for extracorporeal membrane oxygenation and its use in the critical care setting.

  2020年05月, Circulation journal : official journal of the Japanese Circulation Society, 84(6) (6), 1039 - 1043, 英語, 国内誌

  研究論文（学術雑誌）


• Joint Declaration on COVID-19 by the Japan Stroke and Japanese Circulation Societies.

  Takuya Kishi, Teruyuki Hirano, Atsushi Mizuno, Yoichiro Hashimoto, Chisa Matsumoto, Memori Fukuda, Shoji Sanada, Mari Ishida, Koichi Node, Susumu Miyamoto, Issei Komuro

  2020年05月, Circulation reports, 2(6) (6), 343 - 344, 英語, 国内誌

  研究論文（学術雑誌）


• Potential Role of Twitter at an Annual Congress in Japan - Narrative Literature Review of "Tweet the Meeting".

  Atsushi Mizuno, Takuya Kishi, Chisa Matsumoto, Fujimi Kawai, Mari Ishida, Shoji Sanada, Seiji Hokimoto, Yoshihiko Saito, Keiko Yamauchi-Takihara, Issei Komuro, Koichi Node

  Background: Twitter has become increasingly popular at annual medical congresses as a platform to communicate to attendees. In contrast, Twitter is not as frequently used in Japan as compared with other countries. Herein, we reviewed the literature and discuss the potential role and risks of "tweet the meeting" in Japan. Methods and Results: We performed a literature review to consider the recent trend of tweeting the meeting, including benefits and how to tweet, as well as potential risks. Upon officially deciding to tweet the meeting, a number of societies and professional organizations developed strategies to enhance the attendees' experience using multiple modalities and guides. Although there are several risks, we provide a concise guide to tweeting the meeting for the Japanese audience, which could be useful for understanding what should be done before and during a conference. Conclusions: The use of Twitter at medical congresses has many possibilities, and there are numerous potentials in many areas. We should discuss this in the light of the benefits for congress attendees in Japan.

  2019年09月, Circulation reports, 1(10) (10), 401 - 404, 英語, 国内誌

  研究論文（学術雑誌）


• 超高齢化・医療費膨張時代における循環器医療提供体制と医療政策のあり方 心血管系医療制度を改善するための急性心血管疾患の指標と転帰予測モデルの確立(Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System)

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, 英語

  [査読有り]


• 大阪大学医学部附属病院における臨床研究法への対応

  浅野 健人, 岩崎 幸司, 小林 万紀子, 真田 昌爾, 山本 洋一

  (株)臨床評価刊行会, 2019年02月, 臨床評価, 46(3-4) (3-4), 489 - 495, 日本語


• Importance of quality assessment in clinical research in Japan

  Rieko Ueda, Yuji Nishizaki, Yasuhiro Homma, Shoji Sanada, Toshiaki Otsuka, Shinji Yasuno, Kotone Matsuyama, Naotake Yanagisawa, Masashi Nagao, Kazutoshi Fujibayashi, Shuko Nojiri, Yumiko Seo, Natsumi Yamada, Patrick Devos, Hiroyuki Daida

  2019年, Frontiers in Pharmacology, 10

  [査読有り]

  研究論文（学術雑誌）


• Anti-HB-EGF Antibody-Mediated Delivery of siRNA to Atherosclerotic Lesions in Mice.

  Tsuchida S, Matsuzaki T, Yamato M, Okuda K, Fu HY, Araki R, Sanada S, Asanuma H, Asano Y, Asakura M, Hao H, Takashima S, Kitakaze M, Sakata Y, Mekada E, Minamino T

  2018年11月, International heart journal, 59(6) (6), 1425 - 1431

  [査読有り]


• Development of a novel one-step production system for injectable liposomes under GMP.

  Araki R, Matsuzaki T, Nakamura A, Nakatani D, Sanada S, Fu HY, Okuda K, Yamato M, Tsuchida S, Sakata Y, Minamino T

  2018年07月, Pharmaceutical development and technology, 23(6) (6), 602 - 607

  [査読有り]


• Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts

  Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze

  2017年12月, CARDIOVASCULAR DRUGS AND THERAPY, 31(5-6) (5-6), 501 - 510, 英語

  [査読有り]

  研究論文（学術雑誌）


• RNA Aptamer Binds Heparin-Binding Epidermal Growth Factor-Like Growth Factor with High Affinity and Specificity and Neutralizes Its Activity

  Masaki Yamato, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Keiji Okuda, Hai Ying Fu, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Hiroomi Torii, Kentaro Noi, Hirotsugu Ogi, Ryo Iwamoto, Eisuke Mekada, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

  2017年09月, INTERNATIONAL JOURNAL OF GERONTOLOGY, 11(3) (3), 191 - 196, 英語

  研究論文（学術雑誌）


• Ablation of IL-33 gene exacerbate myocardial remodeling in mice with heart failure induced by mechanical stress

  Punniyakoti T. Veeraveedu, Shoji Sanada, Keiji Okuda, Hai Ying Fu, Takashr Matsuzaki, Ryo Araki, Masaki Yamato, Koubun Yasuda, Yasushi Sakata, Tomohiro Yoshimoto, Tetsuo Minamino

  2017年08月, BIOCHEMICAL PHARMACOLOGY, 138, 73 - 80, 英語

  [査読有り]

  研究論文（学術雑誌）


• Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats

  Keiji Okuda, Hai Ying Fu, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Punniyakoti V. Thanikachalam, Tatsuya Fukuta, Tomohiro Asai, Masaki Yamato, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Haruo Hanawa, Hiroyuki Hao, Naoto Oku, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino

  2016年08月, PLOS ONE, 11(8) (8), e0160944, 英語

  [査読有り]

  研究論文（学術雑誌）


• Identification of the Mtus1 Splice Variant as a Novel Inhibitory Factor Against Cardiac Hypertrophy.

  Ito S, Asakura M, Liao Y, Min KD, Takahashi A, Shindo K, Yamazaki S, Tsukamoto O, Asanuma H, Mogi M, Horiuchi M, Asano Y, Sanada S, Minamino T, Takashima S, Mochizuki N, Kitakaze M

  2016年07月, Journal of the American Heart Association, 5(7) (7), 英語

  [査読有り]

  研究論文（学術雑誌）


• Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction

  Hai Ying Fu, Shoji Sanada, Takashi Matsuzaki, Yulin Liao, Keiji Okuda, Masaki Yamato, Shota Tsuchida, Ryo Araki, Yoshihiro Asano, Hiroshi Asanuma, Masanori Asakura, Brent A. French, Yasushi Sakata, Masafumi Kitakaze, Tetsuo Minamino

  2016年03月, CIRCULATION RESEARCH, 118(5) (5), 798 - 809, 英語

  [査読有り]

  研究論文（学術雑誌）


• Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO.

  Asanuma H, Sanada S, Asakura M, Asano Y, Kim J, Shinozaki Y, Mori H, Minamino T, Takashima S, Kitakaze M

  2014年08月, Hypertension research : official journal of the Japanese Society of Hypertension, 37(8) (8), 716 - 23, 英語

  [査読有り]

  研究論文（学術雑誌）


• Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice.

  Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M

  2013年05月, American journal of physiology. Heart and circulatory physiology, 304(10) (10), H1361 - 9

  [査読有り]


• Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model.

  Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T

  2013年04月, Cardiovascular drugs and therapy, 27(2) (2), 125 - 132

  [査読有り]


• イヌ心臓において新たに合成したラジカル含有ナノ粒子は一酸化窒素を介して虚血再灌流傷害後の心保護を増大させる(Novel Synthesized Radical-containing Nanoparticles Augment Cardioprotection after Ischemia-reperfusion Injury via Nitric Oxide in Canine Hearts)

  Yoshida Akemi, Asanuma Hiroshi, Sanada Shoji, Sasaki Hideyuki, Takahama Hiroyuki, Asakura Masanori, Minamino Tetsuo, Takashima Seiji, Mochizuki Naoki, Kitakaze Masafumi

  (一社)日本循環器学会, 2013年03月, Circulation Journal, 77(Suppl.I) (Suppl.I), 141 - 141, 英語


• Smoking Promotes Subclinical Atherosclerosis in Apparently Healthy Men-2-Year Ultrasonographic Follow-up -

  Shoji Sanada, Makoto Nishida, Kouki Ishii, Toshiki Moriyama, Issei Komuro, Keiko Yamauchi-Takihara

  2012年12月, CIRCULATION JOURNAL, 76(12) (12), 2884 - 2891, 英語

  [査読有り]

  研究論文（学術雑誌）


• H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs.

  Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M

  2012年06月, Cardiovascular drugs and therapy, 26(3) (3), 217 - 226

  [査読有り]


• 地域ベースの集団における左室拡張機能障害と左室肥大の有病率、およびそれらの関係(Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-based Population)

  Hasegawa Takuya, Asakura Masanori, Kanzaki Hideaki, Kim Jiyoong, Asanuma Hiroshi, Sanada Shoji, Funada Akira, Amaki Makoto, Takahama Hiroyuki, Kitakaze Masafumi

  (一社)日本循環器学会, 2012年03月, Circulation Journal, 76(Suppl.I) (Suppl.I), 2679 - 2679, 英語


• WEB調査票システムの構築と学生健診への導入

  明石美智子, 白根峰子, 大浜透, 市川昊平, 江原康生, 西田誠, 真田昌爾, 守山敏樹, 杉田義郎, 瀧原圭子

  (公社)全国大学保健管理協会, 2012年, Campus Health, 49(4) (4), 77 - 77, 日本語


• Repetitive transient phosphodiesterase-3 inhibition eliminates non-ischemic cardiac remodeling and failure

  Shoji Sanada, Hiroshi Asanuma, Tetsuo Minamino, Osamu Tsukamoto, Kenichiro Okada, Masafumi Kitakaze, Issei Komuro

  Bentham Science Publishers B.V., 2012年, Immunology, Endocrine and Metabolic Agents in Medicinal Chemistry, 12(2) (2), 130 - 136, 英語

  [査読有り]

  研究論文（学術雑誌）


• Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model.

  Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K

  2012年01月, Journal of cardiology, 59(1) (1), 91 - 96

  [査読有り]


• Costarring statins with ARBs: Going to be a smash hit?

  Shoji Sanada, Issei Komuro

  2011年, Circulation Journal, 75(3) (3), 540 - 541, 英語

  [査読有り]

  研究論文（学術雑誌）


• A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.

  Takahama H, Asanuma H, Sanada S, Fujita M, Sasaki H, Wakeno M, Kim J, Asakura M, Takashima S, Minamino T, Komamura K, Sugimachi M, Kitakaze M

  2010年11月, Basic research in cardiology, 105(6) (6), 787 - 794

  [査読有り]


• Isoform-specific Intermolecular Disulfide Bond Formation of Heterochromatin Protein 1 (HP1)

  Shuichiro Higo, Yoshihiro Asano, Hisakazu Kato, Satoru Yamazaki, Atsushi Nakano, Osamu Tsukamoto, Osamu Seguchi, Mitsutoshi Asai, Masanori Asakura, Hiroshi Asanuma, Shoji Sanada, Tetsuo Minamino, Issei Komuro, Masafumi Kitakaze, Seiji Takashima

  2010年10月, JOURNAL OF BIOLOGICAL CHEMISTRY, 285(41) (41), 31337 - 31347, 英語

  [査読有り]

  研究論文（学術雑誌）


• Ablation of C/EBP homologous protein attenuates ER-mediated apoptosis and cardiac dysfunction induced by pressure overload.

  Fu HY, Okada Ki, Liao Y, Tsukamoto O, Isomura T, Asai M, Sawada T, Okuda K, Asano Y, Sanada S, Asanuma H, Asakura M, Takashima S, Komuro I, Kitakaze M, Minamino T

  2010年08月, Circulation, 英語

  [査読有り]

  研究論文（学術雑誌）


• X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes

  Tamaki Sawada, Tetsuo Minamino, Hai Ying Fu, Mitsutoshi Asai, Keiji Okuda, Tadashi Isomura, Satoru Yamazaki, Yoshihiro Asano, Ken-ichiro Okada, Osamu Tsukamoto, Shoji Sanada, Hiroshi Asanuma, Masanori Asakura, Seiji Takashima, Masafumi Kitakaze, Issei Komuro

  2010年06月, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 48(6) (6), 1280 - 1289, 英語

  [査読有り]

  研究論文（学術雑誌）


• Identification of genes related to heart failure using global gene expression profiling of human failing myocardium

  Kyung-Duk Min, Masanori Asakura, Yulin Liao, Kenji Nakamaru, Hidetoshi Okazaki, Tomoko Takahashi, Kazunori Fujimoto, Shin Ito, Ayako Takahashi, Hiroshi Asanuma, Satoru Yamazaki, Tetsuo Minamino, Shoji Sanada, Osamu Seguchi, Atsushi Nakano, Yosuke Ando, Toshiaki Otsuka, Hidehiko Furukawa, Tadashi Isomura, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

  2010年02月, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(1) (1), 55 - 60, 英語

  [査読有り]

  研究論文（学術雑誌）


• Interleukin-33 Prevents Apoptosis and Improves Survival After Experimental Myocardial Infarction Through ST2 Signaling

  Kenjiro Seki, Shoji Sanada, Anastacia Y. Kudinova, Matthew L. Steinhauser, Vandna Handa, Joseph Gannon, Richard T. Lee

  2009年11月, CIRCULATION-HEART FAILURE, 2(6) (6), 684 - U211, 英語

  [査読有り]

  研究論文（学術雑誌）


• Metformin Prevents Progression of Heart Failure in Dogs Role of AMP-Activated Protein Kinase

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masakatsu Wakeno, Shin Ito, Akiko Ogai, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Masaru Sugimachi, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze

  2009年05月, CIRCULATION, 119(19) (19), 2568 - U74, 英語

  [査読有り]

  研究論文（学術雑誌）


• Cardiac Iodine-123 Metaiodobenzylguanidine Imaging Predicts Sudden Cardiac Death Independently of Left Ventricular Ejection Fraction in Patients With Chronic Heart Failure and Left Ventricular Systolic Dysfunction Results From a Comparative Study With Signal-Averaged Electrocardiogram, Heart Rate Variability, and QT Dispersion

  Shunsuke Tamaki, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yasumasa Tsukamoto, Masaharu Masuda, Keiji Okuda, Yusuke Iwasaki, Taku Yasui, Masatsugu Hori, Masatake Fukunami

  2009年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(5) (5), 426 - 435, 英語

  [査読有り]

  研究論文（学術雑誌）


• Sodium bicarbonate improves long-term clinical outcomes compared with sodium chloride in patients with chronic kidney disease undergoing an emergent coronary procedure

  Masaharu Masuda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Yuusuke Iwasaki, Taku Yasui, Masatake Fukunami

  2008年10月, CIRCULATION JOURNAL, 72(10) (10), 1610 - 1614, 英語

  [査読有り]

  研究論文（学術雑誌）


• Activation of ecto-5'-nucleotidase in the blood and hearts of patients with chronic heart failure.

  Fujita M, Asakura M, Sanada S, Funaya H, Tsukamoto O, Komamura K, Asanuma H, Taketani S, Isomura T, Nakamaru K, Furukawa H, Sawa Y, Hori M, Kitakaze M

  2008年06月, Journal of cardiac failure, 14(5) (5), 426 - 430

  [査読有り]


• Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.

  Sanada S, Asanuma H, Koretsune Y, Watanabe K, Nanto S, Awata N, Hoki N, Fukunami M, Kitakaze M, Hori M

  2007年10月, Hypertension research : official journal of the Japanese Society of Hypertension, 30(10) (10), 913 - 919

  [査読有り]


• IL-33 and ST2 comprise a critical biomechanically induced and card ioprotective signaling system

  Shoji Sanada, Daihiko Hakuno, Luke J. Higgins, Eric R. Schreiter, Andrew N. J. McKenzie, Richard T. Lee

  2007年06月, JOURNAL OF CLINICAL INVESTIGATION, 117(6) (6), 1538 - 1549, 英語

  [査読有り]

  研究論文（学術雑誌）


• S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.

  Asanuma H, Nakai K, Sanada S, Minamino T, Takashima S, Ogita H, Fujita M, Hirata A, Wakeno M, Takahama H, Kim J, Asakura M, Sakuma I, Kitabatake A, Hori M, Komamura K, Kitakaze M

  2007年, J Mol Cell Cardiol, 2007, 924 - 930, 英語

  [査読有り]

  研究論文（学術雑誌）


• The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.

  Tsukamoto O, Minamino T, Sanada S, Okada K, Hirata A, Fujita M, Shintani Y, Yulin L, Asano Y, Takashima S, Yamasaki S, Tomoike H, Hori M, Kitakaze M

  2006年04月, Cardiovasc Drugs Ther., 英語

  [査読有り]

  研究論文（学術雑誌）


• Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.

  Asanuma H, Minamino T, Ogai A, Kim J, Asakura M, Komamura K, Sanada S, Fujita M, Hirata A, Wakeno M, Tsukamoto O, Shinozaki Y, Myoishi M, Takashima S, Tomoike H, Kitakaze M

  2006年04月, J Mol Cell Cardiol., 英語

  [査読有り]

  研究論文（学術雑誌）


• Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts.

  Fujita M, Minamino T, Asanuma H, Sanada S, Hirata A, Wakeno M, Myoishi M, Okuda H, Ogai A, Okada K, Tsukamoto O, Koyama H, Hori M, Kitakaze M

  2005年07月, Hypertension (Dallas, Tex. : 1979), 46(1) (1), 113 - 117

  [査読有り]


• Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model

  Y Li, T Minamino, O Tsukamoto, T Yujiri, Y Shintani, K Okada, Y Nagamachi, M Fujita, A Hirata, S Sanada, H Asanuma, S Takashima, M Hori, GL Johnson, M Kitakaze

  2005年04月, CIRCULATION, 111(13) (13), 1672 - 1678, 英語

  [査読有り]

  研究論文（学術雑誌）


• Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the phosphatidylinositol-3 kinase-dependent pathway in canine hearts.

  Hirata A, Minamino T, Asanuma H, Sanada S, Fujita M, Tsukamoto O, Wakeno M, Myoishi M, Okada K, Koyama H, Komamura K, Takashima S, Shinozaki Y, Mori H, Tomoike H, Hori M, Kitakaze M

  2005年01月, Cardiovascular drugs and therapy, 19(1) (1), 33 - 40

  [査読有り]


• A calcium channel blocker amlodipine increases coronary blood flow via both adenosine- and NO-dependent mechanisms in ischemic hearts.

  Asanuma H, Minamino T, Sanada S, Ogita H, Kim J, Fujita M, Hirata A, Tsukamoto O, Ogai A, Node K, Hori M, Tomoike H, Kitakaze M

  2005年, J Mol Cell Cardiol, 39, 605 - 614, 英語

  [査読有り]

  研究論文（学術雑誌）


• Opening of Ca2+-activated K+ channels is involved in ischemic preconditioning in canine hearts.

  Shintani Y, Node K, Asanuma H, Sanada S, Takashima S, Asano Y, Liao Y, Fujita M, Hirata A, Shinozaki Y, Fukushima T, Nagamachi Y, Okuda H, Kim J, Tomoike H, Hori M, Kitakaze M

  2004年12月, Journal of molecular and cellular cardiology, 37(6) (6), 1213 - 1218

  [査読有り]


• Ischemic preconditioning: emerging evidence, controversy, and translational trials

  S Sanada, M Kitakaze

  2004年11月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 97(2) (2), 263 - 276, 英語

  [査読有り]


• Optimal Windows of Statin Use for Immediate Infarct-limitation: 5’-Nucleotidase as Another Downstream Molecule of Phosphatidylinositol-3 Kinase.

  Sanada S, Asanuma H, Minamino T, Node K, Takashima S, Okuda H, Shinozaki Y, Ogai A, Asano Y, Fujita M, Hirata A, Kim J, Mori H, Tomoike H, Kitamura S, Hori M, Kitakaze M

  2004年10月, Circulation, 110(15) (15), 2143 - 2149, 英語

  [査読有り]

  研究論文（学術雑誌）


• Are cardiotonic agents cardioprotective?

  Shoji Sanada, Masafumi Kitakaze

  2004年09月, Respiration and Circulation, 52(9) (9), 891 - 896, 日本語

  研究論文（学術雑誌）


• A Vasodilatory β-Blocker, Celiprolol, Inhibits Pressure Overload-induced Cardiac Hypertrophy and Prevents the Transition to Heart Failure via NO-dependent Mechanisms in Mice.

  Liao Y, Asakura M, Takashima S, Ogai A, Asano Y, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, Kitamura S, Tomoike H, Hori M, Kitakaze M

  2004年08月, Circulation, 110(6) (6), 692 - 699, 英語

  [査読有り]

  研究論文（学術雑誌）


• Protein kinase A as another mediator of ischemic preconditioning independent of protein kinase C

  S Sanada, H Asanuma, O Tsukamoto, T Minamino, K Node, S Takashima, T Fukushima, A Ogai, Y Shinozaki, M Fujita, A Hirata, H Okuda, H Shimokawa, H Tomoike, M Hori, M Kitakaze

  2004年07月, CIRCULATION, 110(1) (1), 51 - 57, 英語

  [査読有り]

  研究論文（学術雑誌）


• b-adrenoceptor blocker carvedilol provides cardioprotection via an adenosine-dependent mechanism in ischemic canine hearts

  H Asanuma, T Minamino, S Sanada, S Takashima, H Ogita, A Ogai, M Asakura, YL Liao, Y Asano, Y Shintani, J Kim, Y Shinozaki, H Mori, K Node, S Kitamura, H Tomoike, M Hori, M Kitakaze

  2004年06月, CIRCULATION, 109(22) (22), 2773 - 2779, 英語

  [査読有り]

  研究論文（学術雑誌）


• Lamr1 functional retroposon causes right ventricular dysplasia in mice

  Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, H Asanuma, S Sanada, J Kim, A Ogai, T Fukushima, Y Oikawa, Y Okazaki, Y Kaneda, M Sato, J Miyazaki, S Kitamura, H Tomoike, M Kitakaze, M Hori

  2004年02月, NATURE GENETICS, 36(2) (2), 123 - 130, 英語

  [査読有り]

  研究論文（学術雑誌）


• Raloxifene prevents cardiac hypertrophy and dysfunction in pressure-overloaded mice.

  Ogita H, Node K, Liao Y, Ishikura F, Beppu S, Asanuma H, Sanada S, Takashima S, Minamino T, Hori M, Kitakaze M

  2004年, Hypertension, 43, 237 - 242, 英語

  [査読有り]

  研究論文（学術雑誌）


• Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts.

  Asanuma H, Sanada S, Ogai A, Minamino T, Takashima S, Asakura M, Ogita H, Shinozaki Y, Mori H, Node K, Tomoike H, Hori M, Kitakaze M

  2004年, J Cardiovasc Pharmacol, 43, 574 - 579, 英語

  [査読有り]

  研究論文（学術雑誌）


• Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: Role of phosphatidylinositol 3-kinase/Akt pathway.

  Ogita H, Node K, Asanuma H, Sanada S, Kim J, Takashima S, Minamino T, Hori M, Kitakaze M

  2004年, J Cardiovasc Pharmacol, 43, 237 - 242, 英語

  [査読有り]

  研究論文（学術雑誌）


• Selective blockade of serotonin 5-HT2A receptor increases coronary blood flow via augmented cardiac nitric oxide release through 5-HT1B receptor in hypoperfused canine hearts.

  Fujita M, Minamino T, Sanada S, Asanuma H, Hirata A, Ogita H, Okada K, Tsukamoto O, Takashima S, Tomoike H, Node K, Hori M, Kitakaze M

  2004年, J Mol Cell Cardiol, 37, 1219 - 1223, 英語

  [査読有り]

  研究論文（学術雑誌）


• [The trend of research on the mechanism of reperfusion injury].

  Shoji Sanada, Masatsugu Hori, Koichi Node, Masafumi Kitakaze

  2003年04月, Nihon rinsho. Japanese journal of clinical medicine, 61 Suppl 4, 135 - 41, 日本語, 国内誌

  研究論文（学術雑誌）


• Long-acting Ca2+ blockers prevent myocardial remodeling induced by chronic no inhibition in rats.

  Sanada S, Node K, Minamino T, Takashima S, Ogai A, Asanuma H, Ogita H, Liao Y, Asakura M, Kim J, Hori M, Kitakaze M

  2003年, Hypertension, 41, 963 - 967, 英語

  [査読有り]

  研究論文（学術雑誌）


• Celiprolol increases coronary blood flow and reduces severity of myocardial ischemia via nitric oxide release.

  Asanuma H, Node K, Minamino T, Sanada S, Takashima S, Ueda Y, Sakata Y, Asakura M, Kim J, Ogita H, Tada M, Hori M, Kitakaze M

  2003年, J Cardiovasc Pharmacol, 41, 499 - 505, 英語

  [査読有り]

  研究論文（学術雑誌）


• Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts.

  Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M, Kitakaze M

  2003年, J Cardiovasc Pharmacol, 41, 964 - 969, 英語

  [査読有り]

  研究論文（学術雑誌）


• Canine DNA array as a potential tool for combining physiology and molecular biology.

  Asakura M, Takashima S, Asano Y, Honma T, Asanuma H, Sanada S, Shintani Y, Liao Y, Kim J, Ogita H, Node K, Minamino T, Yorikane R, Agai A, Kitamura S, Tomoike H, Hori M, Kitakaze M

  2003年, Circ J, 67, 788 - 792, 英語

  [査読有り]

  研究論文（学術雑誌）


• Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model.

  Liao Y, Takashima S, Asano Y, Asakura M, Ogai A, Shintani Y, Minamino T, Asanuma H, Sanada S, Kim J, Ogita H, Tomoike H, Hori M, Kitakaze M

  2003年, Circ Res, 93, 759 - 766, 英語

  [査読有り]

  研究論文（学術雑誌）


• Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart

  Hisakazu Ogita, Koichi Node, Hiroshi Asanuma, Shoji Sanada, Yulin Liao, Seiji Takashima, Masanori Asakura, Hidezo Mori, Yoshiro Shinozaki, Masatsugu Hori, Masafumi Kitakaze

  2002年09月, Journal of the American College of Cardiology, 40(5) (5), 998 - 1005, 英語

  [査読有り]

  研究論文（学術雑誌）


• Opening of ATP-sensitive Potassium Channel Attenuates Cardiac Remodeling Induced by Chronic Inhibition of Nitric Oxide Synthesis -Role of 70kDa S6 Kinase and Extracellular Signal-regulated Kinase－

  Sanada S, Node K, Asanuma H, Ogita H, Takashima S, Minamino T, Asakura M, Liao Y, Ogai A, Kim J, Hori M, Kitakaze M

  2002年09月, J Am Coll Cardiol., 40(5) (5), 991 - 997, 英語

  [査読有り]

  研究論文（学術雑誌）


• Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis - Role of 70-kDa S6 kinase and extracellular signal-regulated kinase

  S Sanada, K Node, H Asanuma, H Ogita, S Takashima, T Minamino, M Asakura, WL Liao, A Ogai, J Kim, M Hori, M Kitakaze

  2002年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 40(5) (5), 991 - 997, 英語

  [査読有り]

  研究論文（学術雑誌）


• Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium: Role of bradykinin

  Masafumi Kitakaze, Hiroshi Asanuma, Hiroharu Funaya, Koichi Node, Seiji Takashima, Shoji Sanada, Masanori Asakura, Hisakazu Ogita, Jiyoong Kim, Masatsugu Hori

  2002年07月, Journal of the American College of Cardiology, 40(1) (1), 162 - 166, 英語

  [査読有り]

  研究論文（学術雑誌）


• Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

  S Takashima, M Kitakaze, M Asakura, H Asanuma, S Sanada, F Tashiro, H Niwa, J Miyazaki, S Hirota, Y Kitamura, T Kitsukawa, H Fujisawa, M Klagsbrun, M Hori

  2002年03月, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99(6) (6), 3657 - 3662, 英語

  [査読有り]

  研究論文（学術雑誌）


• Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy

  M Asakura, M Kitakaze, S Takashima, Y Liao, F Ishikura, T Yoshinaka, H Ohmoto, K Node, K Yoshino, H Ishiguro, H Asanuma, S Sanada, Y Matsumura, H Takeda, S Beppu, M Tada, M Hori, S Higashiyama

  2002年01月, NATURE MEDICINE, 8(1) (1), 35 - 40, 英語

  [査読有り]

  研究論文（学術雑誌）


• [Amelioration of ischemia- and reperfusion-induced myocardial injury by the selective estrogen receptor modulator, raloxifene, in the canine heart].

  Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Asakura M, Kitakaze M, Hori M

  2002年01月, Journal of cardiology, 39(1) (1), 55 - 56

  [査読有り]


• Echocardiographic assessment of LV hypertrophy and function in aortic-banded mice: Necropsy validation.

  Liao Y, Ishikura F, Beppu S, Asakura M, Takashima S, Asanuma H, Sanada S, Kim J, Ogita H, Kuzuya T, Node K, Kitakaze M, Hori M

  2002年, Am J Physiol Heart Circ Physiol, 282, H1703-H1708, 英語

  [査読有り]

  研究論文（学術雑誌）


• Adenosine-induced cardiac gene expression of ischemic murine hearts revealed by cDNA array hybridization.

  Asakura M, Kitakaze M, Sakata Y, Asanuma H, Sanada S, Kim J, Ogita H, Liao Y, Node K, Takashima S, Tada M, Hori M

  2002年, Circ J, 66, 93 - 96, 英語

  [査読有り]

  研究論文（学術雑誌）


• Cardioprotective Effect Afforded by Transient Exposure to Phosphodiesterase-III Inhibitors. -The Role of Protein Kinase A and P38 Mitogen-activated Protein Kinase-

  Sanada S, Kitakaze M, Asanuma H, Papst PJ, Node K, Liao Y, Shinozaki Y, Ogita H, Takashima S, Sakata Y, Asakura M, Kuzuya T, Terada N, Mori H, Hori M

  2001年10月, Circulation, 104, 705 - 710, 英語

  [査読有り]

  研究論文（学術雑誌）


• Nifedipine limits infarct size via NO-dependent mechanisms in dogs.

  H Asanuma, M Kitakaze, H Funaya, S Takashima, T Minamino, K Node, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, T Kuzuya, M Tada, M Hori

  OBJECTIVES: Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that nifedipine increases cardiac NO levels in the ischemic canine hearts, suggesting that nifedipine may also have protective effects against ischemia and reperfusion injury, because the enhancement of NO production limits infarct size. We tested whether nifedipine limits infarct size via NO-dependent mechanisms. METHODS: In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed at 6 hours of reperfusion. Nifedipine of 3 or 6 microg/kg/min was infused into the bypass tube between 10 min prior to the onset of ischemia and 60 min of reperfusion. RESULTS: Neither systemic blood pressure nor heart rate changed during infusion of nifedipine. Infarct size was reduced by the administration of nifedipine (3 or 6 microg/kg/min) compared with the untreated condition (25.6+/-2.6 and 19.1+/-3.5 vs. 43.4+/-5.6%, respectively), which was completely blunted by L-NAME (45.0+/-3.6 and 45.4+/-4.2 vs. 47.9+/-3.9% in the nifedipine (3 or 6 microg/kg/min) with L-NAME groups vs. the L-NAME group). Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by nifedipine. The limitation of infarct size and the attenuation in myeloperoxidase actiivity were completely blunted by L-NAME. There were no significant differences in collateral blood flow at 45 min of ischemia between each group. CONCLUSIONS: We conclude that the Ca channel blocker, nifedipine, limits infarct size via NO-dependent mechanisms.

  2001年09月, Basic research in cardiology, 96(5) (5), 497 - 505, 英語, 国際誌

  研究論文（学術雑誌）


• Role of cellular acidosis in production of nitric oxide in canine ischemic myocardium

  M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Shinozaki, H Mori, H Sato, T Kuzuya, M Hori

  2001年09月, JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 33(9) (9), 1727 - 1737, 英語

  [査読有り]

  研究論文（学術雑誌）


• Role of Phasic Dynamism of P38 Mitogen-activated Protein Kinase Activation in the Ischemic Preconditioning on the Canine Heart.

  Sanada S, Kitakaze M, Papst PJ, Hatanaka K, Asanuma H, Aki T, Shinozaki Y, Ogita H, Node K, Takashima S, Asakura M, Kuzuya T, Mori H, Terada N, Yoshida Ki, Hori M

  2001年07月, Circ Res., 88, 175 - 180, 英語

  [査読有り]

  研究論文（学術雑誌）


• cDNA array hybridization reveals cardiac gene expression in acute ischemic murine hearts.

  Kitakaze M, Asakura M, Sakata Y, Asanuma H, Sanada S, Kuzuya T, Miyazaki J, Takashima S, Hori M

  2001年03月, Cardiovasc Drugs Ther, 15: 125-130, 英語

  研究論文（学術雑誌）


• Benidipine, a long-acting Ca channel blocker, limits infarct size via bradykinin- and NO-dependent mechanisms in canine hearts.

  H Asanuma, M Kitakaze, K Node, S Takashima, Y Sakata, M Asakura, S Sanada, Y Shinozaki, H Mori, M Tada, T Kuzuya, M Hori

  Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion injury via bradykinin- and NO-dependent mechanisms. We examined this possibility. In open chest dogs, the left anterior descending coronary artery was perfused with blood through a bypass tube and was occluded for 90 min followed by 6 hours of reperfusion. Infarct size was assessed by TTC staining at 6 hours of reperfusion. When benidipine doses of 50, 100, and 200 ng/kg/min were infused via the bypass tube between 10 min prior to the onset of ischemia and after 60 min of reperfusion, systemic blood pressure did not change significantly. Infarct size decreased with the administration of benidipine (50, 100, and 200 ng/kg/min) when compared to the untreated condition (24.8+/-2.5, 17.3+/-3.1, and 16.5+/-2.0 vs. 43.4+/-5.6%, respectively) associated with the increased release of NO and bradykinin in the coronary venous blood upon reperfusion. Myeloperoxidase activity of the myocardium increased after 6 hours of reperfusion, which was attenuated by benidipine. The limitation of infarct size and the increase in myeloperoxidase activity were completely blunted by either L-NAME or HOE140. There were no significant differences in collateral blood flow assessed by the microsphere method after 45 min of ischemia for any of the groups. Thus, we conclude that the Ca channel blocker, benidipine, limits infarct size via bradykinin- and NO-dependent mechanisms.

  2001年, Cardiovascular drugs and therapy, 15(3) (3), 225 - 31, 英語, 国際誌

  研究論文（学術雑誌）


• Role of mitochondrial and sarcolemmal KATP channels in ischemic preconditioning of the canine heart.

  Sanada S, Kitakaze M, Asanuma H, Harada K, Ogita H, Node K, Takashima S, Sakata Y, Asakura M, Shinozaki Y, Mori H, Kuzuya T, Hori M

  2001年, Am J Physiol Heart Circ Physiol, 280, H256-H263, 英語

  [査読有り]

  研究論文（学術雑誌）


• Differential subcellular actions of ACE inhibitors and AT1 receptor antagonists on cardiac remodeling induced by chronic inhibition of no synthesis in rats.

  Sanada S, Kitakaze M, Node K, Takashima S, Ogai A, Asanuma H, Sakata Y, Asakura M, Ogita H, Liao Y, Fukushima T, Yamada J, Minamino T, Kuzuya T, Hori M

  2001年, Hypertension, 38, 404 - 411, 英語

  [査読有り]

  研究論文（学術雑誌）


• 虚血プレコンディショニングの分子メカニズムの解明-細胞膜 ・ ミトコンドリアATP感受性K^+チャネル開口による相加的心筋梗塞サイズ縮小効果

  北風 政史, 真田 昌爾, 浅沼 博司, 野出 孝一, 南野 哲男, 高島 成二, 中篠 光章, 篠崎 芳郎, 盛 英三, 葛谷 恒彦, 堀 正二

  先行する短時間心筋虚血 (ischemic preconditioning) は, 長時間虚血により生じる心筋壊死サイズを縮小する.本研究では, 麻酔開胸イヌを用いそのメカニズムを検討した.その結果, 1) ischemic preconditioningによる心筋梗塞サイズ縮小効果には, アデノシン産生酵素活性化が関与する, 2) protein kinase C活性化に加えてATP感受性K⁺チャネル開口がアデノシン産生酵素活性化に関与する, 3) 細胞膜・ミトコンドリアに存在するATP感受性K⁺チヤネルが独立して相加的にischemic preconditioningに関与する, ことが明らかになった.以上の結果より, ischemic preconditioningによる心筋保護作用にはアデノシンーアデノシン産生酵素・protein kinase C・ATP感受性K⁺チャネル開口が連関している可能性が示された.

  The Japanese Society of Electrocardiology, 2000年03月, 心電図 = Electrocardiology, 20(2) (2), 103 - 111, 日本語


• Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs.

  Kitakaze M, Asanuma H, Takashima S, Minamino T, Ueda Y, Sakata Y, Asakura M, Sanada S, Kuzuya T, Hori M

  2000年02月, Circulation, 英語

  [査読有り]

  研究論文（学術雑誌）


• Dispersion of signal-averaged P wave duration on precordial body surface in patients with paroxysmal atrial fibrillation

  T. Yamada, M. Fukunami, T. Shimonagata, K. Kumagai, S. Sanada, H. Ogita, Y. Asano, M. Hori, N. Hoki

  1999年02月, European Heart Journal, 20(3) (3), 211 - 220, 英語

  [査読有り]

  研究論文（学術雑誌）


• Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide.

  Minamino T, Kitakaze M, Sanada S, Asanuama H, Kurotobi T, Koretsune Y, Fukunami M, Kuzuya T, Hoki N, Hori M

  1998年10月, Circulation, 33(2) (2), 103 - 104, 英語

  [査読有り]

  研究論文（学術雑誌）


• Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation - Role of nitric oxide

  T Minamino, M Kitakaze, S Sanada, H Asanuama, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori

  1998年10月, CIRCULATION, 98(17) (17), 1721 - 1727, 英語

  [査読有り]

  研究論文（学術雑誌）


• Prediction of the effectiveness of long-term beta blocker treatment for dilated cardiomyopathy by signal averaged electrocardiography.

  Yamada T, Fukunami M, Shimonagata T, Kumagai K, Kim J, Sanada S, Ogita H, Hori M, Hoki N

  1998年, Heart, 79, 256 - 261, 英語

  [査読有り]

  研究論文（学術雑誌）


• Prediction of transition to chronic atrial fibrillation in patients with paroxysmal atrial fibrillation by signal-averaged electrocardiography: a prospective study.

  Abe Y, Fukunami M, Yamada T, Ohmori M, Shimonagata T, Kumagai K, Kim J, Sanada S, Hori M, Hoki N

  1997年11月, Circulation, 96, 2612 - 2616, 英語

  [査読有り]

  研究論文（学術雑誌）


• Detection of patients with sick sinus syndrome by use of low amplitude potentials early in filtered P wave

  Takahisa Yamada, Masatake Fukunami, Kazuaki Kumagai, Yasushi Abe, Jiyoong Kim, Shoji Sanada, Masatsugu Hori, Takenobu Kamada, Noritake Hoki

  Elsevier USA, 1996年, Journal of the American College of Cardiology, 28(3) (3), 738 - 744, 英語

  [査読有り]

  研究論文（学術雑誌）

• 臨床研究法で定義される「研究開発計画支援担当者」および「調整管理実務担当者」のコア・コンピテンシー・モデルの開発に関する研究

  岩崎 幸司, 今野 浩一, 菊地 佳代子, 大塚 佑基, 松山 琴音, 秦 友美, 真田 昌爾

  ライフサイエンス出版(株), 2020年07月, 薬理と治療, 48(Suppl.1) (Suppl.1), s65 - s80, 日本語

  [査読有り]


• Establishment of Indicators and Outcome Prediction Model of Acute Cardiovascular Diseases to Improve Cardiovascular Medical Service System

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 添田 恒有, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 島村 和男, 土肥 智晴, 岡田 佳築, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, SY24 - 1, 英語


• わが国の循環器医療提供体制の課題と展望 望ましい体制を構築するための急性冠症候群および急性大動脈症候群の医療体制を示す指標を創造する試み(Efforts on Creating Index of Medical Service System for Acute Coronary Syndrome and Acute Aortic Syndrome to Construct Desirable System)

  坂田 泰史, 磯部 光章, 安田 聡, 宮本 恵宏, 西村 邦宏, 中村 文明, 斎藤 能彦, 今村 知明, 平山 篤志, 辻田 賢一, 中尾 浩一, 森野 禎浩, 上田 裕一, 高山 守正, 真田 昌爾, 彦惣 俊吾, 小室 一成

  (一社)日本循環器学会, 2018年03月, 日本循環器学会学術集会抄録集, 82回, SY11 - 4, 英語


• Quality by Designによる質の高い臨床研究実施計画書作成を志向するツール作成の試み

  松山 琴音, 松嶋 由紀子, 林 宏至, 真田 昌爾, 須崎 友紀, 長尾 典明, 小澤 郷司, 吉田 浩輔, 岩崎 幸司, 山本 学, 山口 拓洋, 上村 尚人

  (一社)日本臨床薬理学会, 2017年11月, 臨床薬理, 48(Suppl.) (Suppl.), S269 - S269, 日本語


• フェーズ1試験において健康男性に心電図上観察された食事性二相性T波変化に関する報告

  姚 香景, 中谷 大作, 真田 昌爾, 砂 真一郎, 川村 陽子, 玉井 克人, 山本 洋一, 竹原 徹郎, 名井 陽, 西田 幸二

  (一社)日本臨床薬理学会, 2016年10月, 臨床薬理, 47(Suppl.) (Suppl.), S301 - S301, 日本語


• Cardiac-specific Overexpression of ER Chaperone GRP78 Attenuates Doxorubicin-Induced Cardiac Dysfunction

  Haiying Fu, Takashi Matsuzaki, Shoji Sanada, Tetsuo Minamino

  2014年10月, JOURNAL OF CARDIAC FAILURE, 20(10) (10), S185 - S185, 英語

  研究発表ペーパー・要旨（国際会議）


• Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-Based Population

  Takuya Hasegawa, Masanori Asakura, Hideaki Kanzaki, Jiyoong Kim, Hiroshi Asanuma, Shoji Sanada, Akira Funada, Makoto Amaki, Hiroyuki Takahama, Takahiro Ohara, Toshihisa Anzai, Masafumi Kitakaze

  2012年11月, CIRCULATION, 126(21) (21), 英語

  研究発表ペーパー・要旨（国際会議）


• Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts

  A. Yoshida, S. Sanada, H. Asanuma, H. Sasaki, H. Takahama, M. Asakura, T. Yoshitomi, Y. Nagasaki, M. Kitakaze

  2012年08月, EUROPEAN HEART JOURNAL, 33, 957 - 957, 英語

  研究発表ペーパー・要旨（国際会議）


• The less embraces the greater in detecting multiple coronary artery disease

  Shoji Sanada, Masafumi Kitakaze, Issei Komuro

  2012年, Circulation Journal, 76(2) (2), 299 - 300, 英語

  書評論文,書評,文献紹介等


• Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

  Shoji Sanada, Issei Komuro, Masafumi Kitakaze

  2011年11月, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 301(5) (5), H1723 - H1741, 英語

  書評論文,書評,文献紹介等


• Inhaled hydrogen gas therapy reduced infarct size via mitochondrial KATP channels and mitochondrial permeability transition pore in a dog model of myocardial ischemia reperfusion injury

  A. Yoshida, H. Asanuma, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, N. Mochizuki, M. Kitakaze

  2011年08月, EUROPEAN HEART JOURNAL, 32, 577 - 577, 英語

  研究発表ペーパー・要旨（国際会議）


• Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model

  Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze

  2010年11月, CIRCULATION, 122(21) (21), 英語

  研究発表ペーパー・要旨（国際会議）


• Combined Renin-Angiotensin System-Inhibition Therapy - What Really Accounts for the Additive Benefits?

  Shoji Sanada, Masafumi Kitakaze

  2010年11月, CIRCULATION JOURNAL, 74(11) (11), 2288 - 2289, 英語

  その他


• Inhalation of hydrogen gas reduced infarct size following ischemia and reperfusion via mitochondrial KATP channels in canine hearts

  A. Yoshida, H. Asanuma, H. Sasaki, S. Sanada, S. Yamazaki, S. Takashima, T. Minamino, M. Asakura, M. Kitakaze

  2010年09月, EUROPEAN HEART JOURNAL, 31, 42 - 42, 英語

  研究発表ペーパー・要旨（国際会議）


• Cardiac I-123 Metaiodobenzylguanidine Imaging Provides Additional Prognostic Power to Seattle Heart Failure Model in Patients With Chronic Heart Failure: A 10-year Follow-up Comparative Study

  Yuki Kuramoto, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Koji Tanaka, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Takeshi Okada, Shunsuke Tamaki, Wayne C. Levy, Masatake Fukunami

  2009年11月, CIRCULATION, 120(18) (18), S861 - S861, 英語

  研究発表ペーパー・要旨（国際会議）


• 運動負荷によりST上昇を認めアセチルコリン負荷にて診断された運動誘発性冠攣縮性狭心症の1例

  安居 琢, 奥山 裕司, 山田 貴久, 森田 孝, 真田 昌爾, 古川 善郎, 増田 正晴, 岩崎 祐介, 上田 宏達, 岡田 健志, 川崎 真佐登, 福並 正剛

  (一社)日本循環器学会, 2009年04月, Circulation Journal, 73(Suppl.II) (Suppl.II), 944 - 944, 日本語


• 極端な1度AV blockのため両室ペーシング率が低下し心不全増悪に陥ったCRT-D植え込み後の拡張型心筋症の1例

  岡田 健志, 奥山 裕司, 古川 善郎, 森田 孝, 真田 昌爾, 増田 正晴, 岩崎 祐介, 安居 琢, 上田 宏達, 川崎 真佐登, 山田 貴久, 福並 正剛

  (一社)日本循環器学会, 2009年04月, Circulation Journal, 73(Suppl.II) (Suppl.II), 945 - 945, 日本語


• Oxidized Low-Density Lipoprotein Levels is a Good Predictor of the Response to Atorvastatin Therapy in Patients with Chronic Heart Failure

  Yamada Takahisa, Okuyama Yuji, Morita Takashi, Sanada Shoji, Furukawa Yoshio, Masuda Masaharu, Iwasaki Yusuke, Yasui Taku, Ueda Hiromichi, Okada Takeshi, Kawasaki Masato, Fukunami Masatake

  社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73(0) (0), 347 - 347, 英語

  研究発表ペーパー・要旨（全国大会，その他学術会議）


• The Optimal Antithrombotic Therapy for Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention With Stenting

  Yusuke Iwasaki, Masatake Fukunami, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Taku Yasui, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki

  2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A429 - A429, 英語

  研究発表ペーパー・要旨（国際会議）


• METFORMIN THERAPY IS ASSOCIATED WITH IMPROVED CARDIAC FUNCTION AND IMPROVED INSULIN RESISTANCE IN DOGS

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Shin Ito, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Kyongduk Min, Kazuo Komamura, Masaru Sugumachi, Naoki Mochizuki, Masafumi Kitakaze

  2009年, JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 316 - 316, 英語

  研究発表ペーパー・要旨（国際会議）


• ブルガダ症候群におけるP波加算平均心電図による心房性不整脈基質の検出

  古川 善郎, 奥山 裕司, 山田 貴久, 森田 孝, 真田 昌爾, 増田 正晴, 岩崎 祐介, 安居 琢, 上田 宏達, 岡田 健志, 川崎 真佐登, 福並 正剛

  (一社)日本不整脈心電学会, 2008年10月, 心電図, 28(5) (5), 474 - 474, 日本語

  記事・総説・解説・論説等（学術雑誌）


• Management of Hyperphosphatemia Is an Important Novel Therapeutic Target In Chronic Heart Failure

  Hiroshi Asanuma, Masanori Asakura, Jiyoong Kim, Hiroyuki Takahama, Hideyuk Sasaki, Shoji Sanada, Takahiro Ohara, Kyondoku Min, Shin Ito, Masashi Fujita, Yoshihiro Asano, Seiji Takashima, Tetsuo Minamino, Kazuo Komamura, Masafumi Kitakaze

  2008年10月, CIRCULATION, 118(18) (18), S433 - S434, 英語

  研究発表ペーパー・要旨（国際会議）


• The Effects of Anglotensin II Receptor Blockade on Atrial Late Potential in Paroxysmal Atrial Fibrillation Patients with Hypertension

  Takashi Morita, Takahisa Yamada, Yuji Okuyama, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasul, Hiromichi Ueda, Takeshi Okada, Masato Kawasaki, Masatake Fukunami

  2008年10月, CIRCULATION, 118(18) (18), S829 - S829, 英語

  研究発表ペーパー・要旨（国際会議）


• Usefulness of Cardiac I-123 Metalodobenzylguanidine Imaging for Predictor of Sudden Cardiac Death in Chronic Heart Failure Patients with Mild to Moderate Systolic Dysfunction : A 10-Year Follow up Study

  Hiromichi Ueda, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Takeshi Okada, Masato Kawasaki, Masataka Fukunami

  2008年10月, CIRCULATION, 118(18) (18), S1067 - S1067, 英語

  研究発表ペーパー・要旨（国際会議）


• Activation of Myocardial AMP-activated Protein Kinase by Metformin Prevents Progression of Heart Failure in Dogs; Involvement of eNOS Activation

  Hideyuki Sasaki, Hiroshi Asanuma, Masashi Fujita, Hiroyuki Takahama, Masanori Asakura, Jiyoong Kim, Tetsuo Minamino, Seiji Takashima, Shoji Sanada, Shin Ito, Kyungduk Min, Kazuo Komamura, Naoki Mochizuki, Masafumi Kitakaze

  2008年10月, CIRCULATION, 118(18) (18), S286 - S287, 英語

  研究発表ペーパー・要旨（国際会議）


• Clinical Significance of Serial Studies of Cardiac I-123 Metaiodobenzylguanidine Imaging for the Prediction of Sudden Death in Patients with Chronic Heart Failure

  Takeshi Okada, Takahisa Yamada, Yuji Okuyama, Takashi Morita, Shoji Sanada, Yoshio Furukawa, Masaharu Masuda, Yusuke Iwasaki, Taku Yasui, Hiromichi Ueda, Masato Kawasaki, Masatake Fukunami

  2008年10月, CIRCULATION, 118(18) (18), S1066 - S1067, 英語

  研究発表ペーパー・要旨（国際会議）


• Cardiac I-123 metaiodobenzylguanidine imaging predicts the risk of cardiac death in patients with chronic heart failure, irrespective of renal dysfunction. A prospective 10-year follow up study

  Yusuke Iwasaki, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Yoshio Furukawa, Shoji Sanada, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Taku Yasui, Masataka Fukunami

  2008年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A160 - A160, 英語

  研究発表ペーパー・要旨（国際会議）


• The combination of cardiac I-123 metaiodobenzylguanidine and subclinical hypothyroidism identifies patients with chronic heart failure at higher risk for poor outcome

  Taku Yesui, Takahisa Yamada, Yuji Okuyama, Takasi Morita, Shoji Sanada, Yoshio Furukawa, Yasumasa Tsukamoto, Keiji Okuda, Masaharu Masuda, Yusuke Iwasaki, Masatake Fukunami

  2008年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A172 - A172, 英語

  研究発表ペーパー・要旨（国際会議）


• Activation of A(1) adenosine receptors inhibits the adrenal aldosterone production and attenuates severity of heart failure

  Osamu Tsukamoto, Tetsuo Minamino, Shoji Sanada, Hidetoshi Okazaki, Ichiro Hisatome, Seiji Takashima, Yasunori Shintani, Yoshihiro Asano, Masafumi Kitakaze

  2006年10月, CIRCULATION, 114(18) (18), 440 - 440, 英語

  研究発表ペーパー・要旨（国際会議）


• Nongenomic effects of alclosterone on ischemic hearts via PKC-dependent pathways

  M Fujita, T Minamino, S Takashima, H Asanuma, S Sanada, A Hirata, M Wakeno, M Myoishi, H Okuda, M Hori, M Kitakaze, A Ogai

  2005年10月, CIRCULATION, 112(17) (17), U76 - U76, 英語

  研究発表ペーパー・要旨（国際会議）


• Erythropoietin enhances neovascularization of ischemic myocardium and improves left ventricular dysfunction after myocardial infarction in dogs

  A Hirata, T Minamino, H Asanuma, S Sanada, M Fujita, M Wakeno, Y Nagamachi, S Takashima, Y Asano, M Hori, M Kitakaze

  2005年10月, CIRCULATION, 112(17) (17), U255 - U255, 英語

  研究発表ペーパー・要旨（国際会議）


• Neovascularization by Erythropoietin Contributes to the Preservation of Left Ventricular Function after Coronary Artery Ligation in Conscious Beagle Dogs(Angiogenesis 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Hirata Akio, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Fujita Masashi, Wakeno Masakatsu, Myoishi Masafumi, Tsukamoto Osamu, Okada ken-ichiro, Komamura Kazuo, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2005年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 69, 493 - 494, 英語


• Nongenomic Deleterious Effects of Aldosterone on Ischemic Hearts via PKC-Dependent Pathway in Dogs(Coronary Circulation, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Fujita Masashi, Minamino Tetsuo, Asanuma Hiroshi, Sanada Shoji, Hirata Akio, Wakeno Masakatsu, Myoishi Masafumi, Okada Ken-ichiro, Tsukamoto Osamu, Okuda Hiroko, Tomoike Hitonobu, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2005年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 69, 468 - 468, 英語


• OJ-442 Gq-stimulation along with low activity of proteasome induces cardiac apoptosis : Potential mechanism of transition from hypertrophy to failure(Heart Failure, Basic 3 (M) : OJ54)(Oral Presentation (Japanese))

  Tsukamoto Osamu, Minamino Tetsuo, Takashima Seiji, Okada Kenichiro, Hirata Akio, Fujita Masashi, Shintani Yasunori, Asano Yoshihiro, Sanada Shoji, Asanuma Hiroshi, Ri Ken, Liao Yulin, Takashima Seiji, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2004年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 68, 337 - 337, 英語


• Active LBP/p40-Retropseudogene interacting with heterochromatin protein 1 causes right ventricular dysplasia

  Y Asano, S Takashima, M Asakura, Y Shintani, YL Liao, T Minamino, S Sanada, T Fukushma, M Hori, M Kitakaze

  2003年10月, CIRCULATION, 108(17) (17), 32 - 32, 英語

  研究発表ペーパー・要旨（国際会議）


• Protein kinase A-induced Rho-kinase inhibition as a novel mediator of ischemic preconditioning independent of protein kinase C

  S Sanada, H Asanuma, O Tsukamoto, S Takashima, Y Liao, T Fukushima, Y Okuda, Y Shinozaki, K Node

  2003年10月, CIRCULATION, 108(17) (17), 186 - 186, 英語

  研究発表ペーパー・要旨（国際会議）


• Selective estrogen receptor modulator raloxifene inhibits the cardiac hypertrophy and dysfunction due to aortic banding in mice

  H Ogita, K Node, H Asanuma, S Sanada, S Takashima, T Minamino, M Asakura, J Kim, Y Liao, Y Asano, Y Shintani, K Okada, M Fujita, A Hirata, O Tsukamoto, M Hori, M Kitakaze

  2003年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 41(6) (6), 228A - 228A, 英語

  研究発表ペーパー・要旨（国際会議）


• Preischemic Protein Kinase-A Activation Evokes Ischemic Preconditioning through Rho-Kinase Inhibition Independent of Protein Kinase-C : A Novel Mechanism

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Kim Jiyoong, Minamino Tetsuo, Takashima Seiji, Fukushima Tomi, Shinozaki Yoshiro, Asakura Masanori, Ogai Akiko, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2003年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 67, 87 - 87, 英語


• Preischemic Protein Kinase-A Activation Triggers Cardioprotection of Ischemic Preconditioning via the Inhibition of Rho-Kinase

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Shinozaki Yoshiro, Mori Hidezo, Shimokawa Hiroaki, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2003年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 67, 303 - 303, 英語


• ATP感受性カリウムチャネル開口が慢性一酸化窒素産生阻害ラットにおける心血管リモデリングを抑制する

  真田 昌爾, 野出 孝一, 浅沼 博司, 扇田 久和, 高島 成二, 南野 哲男, 朝倉 正紀, 堀 正二, 北風 政史

  2003年01月15日, Journal of cardiology, 41(1) (1), 43 - 44, 日本語


• Pravastatin selectively increases coronary blood flow during coronary hypoperfusion through the activation of nitric oxide synthesis in dogs

  S Sanada, H Asanuma, H Ogita, Y Shintani, YL Liao, T Minamino

  2002年11月, CIRCULATION, 106(19) (19), 13 - 13, 英語

  研究発表ペーパー・要旨（国際会議）


• イヌDNAマイクロアレイを用いた慢性心不全の循環生理・分子生物学的病態解析

  浅沼 博司, 朝倉 正紀, 野出 孝一, 高島 成二, 南野 哲男, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史

  (一社)日本心臓病学会, 2002年08月, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 150 - 150, 日本語


• Ca2+感受性K+チャネル開口薬(NS1619)の心筋虚血・再灌流障害抑制効果

  新谷 泰範, 野出 孝一, 浅沼 博司, 真田 昌爾, 扇田 久和, 高島 成二, 朝倉 正紀, 南野 哲男, 朝野 仁裕, 堀 正二, 北風 政史

  (一社)日本心臓病学会, 2002年08月, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 224 - 224, 日本語


• 虚血心におけるアンジオテンシン変換酵素阻害薬とアンジオテンシンII受容体拮抗薬の併用効果 冠血流増加,心筋収縮・代謝不全改善作用

  浅沼 博司, 野出 孝一, 高島 成二, 南野 哲男, 朝倉 正紀, 真田 昌爾, 扇田 久和, 朝野 仁裕, 新谷 泰範, 堀 正二, 北風 政史

  (一社)日本心臓病学会, 2002年08月, Journal of Cardiology, 40(Suppl.1) (Suppl.1), 383 - 383, 日本語


• 虚血プレコンディショニング現象におけるPKA活性化の意義 一過性p38MARK活性化の役割

  真田 昌爾, 北風 政史, 野出 孝一, 浅沼 博司, 扇田 久和, 新谷 泰範, 高島 成二, 南野 哲男, 朝倉 正紀, 朝野 仁裕

  日本適応医学会, 2002年06月, 適応医学, 6(1) (1), 25 - 25, 日本語


• A Role of Transient Preischemic Activation of Protein Kinase-A in Ischemic Preconditioning in Vivo : Involvement of p38 Mitogen-activated Protein Kinase

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Shintani Yasunori, Takashima Seiji, Asakura Masanori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2002年03月31日, Circulation journal : official journal of the Japanese Circulation Society, 66, 697 - 697, 英語


• Rho-kinase Inhibitiors Administered After the Onset of Reperfusion Limit Infarct Size : A Novel Strategy for Adjunctive Therapies Against Myocardial Infarction

  Sanada Shoji, Node Koichi, Asanuma Hiroshi, Ogita Hisakazu, Takashima Seiji, Asakura Masanori, Shintani Yasunori, Asano Yoshihiro, Minamino Tetsuo, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2002年03月31日, Circulation journal : official journal of the Japanese Circulation Society, 66, 699 - 699, 英語


• The Long-acting Calcium Channel Blockers Attenuate Cardiac Hypertrophy Induced by Chronic NO Inhibition : The Investigation of the Potential Subcellular Mechanisms

  Sanada Shoji, Node Koichi, Minamino Tetsuo, Takashima Seiji, Asakura Masanori, Asanuma Hiroshi, Ogita Hisakazu, Asano Yoshihiro, Shintani Yasunori, Hori Masatsugu, Kitakaze Masafumi

  社団法人日本循環器学会, 2002年03月31日, Circulation journal : official journal of the Japanese Circulation Society, 66, 442 - 442, 英語


• Amlodipine increases coronary blood flow and reduces the severity of myocardial ischemia in canine hearts: Roles of NO and adenosine

  R Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 324A - 324A, 英語

  研究発表ペーパー・要旨（国際会議）


• Selective serotonin 5HT(2A) receptor inhibition attenuates myocardial ischemia through the increase in nitric oxide production: The alternative role of 5HT(1B) receptor

  S Sanada, M Kitakaze, K Node, H Asanuma, H Ogita, S Takashima, M Asakura, T Minamino, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 292A - 292A, 英語

  研究発表ペーパー・要旨（国際会議）


• A new development of high fidelity canine DNA microarray: Application for the assessment of gene expressions of reversibly or irreversibly injured ischemic myocardium

  M Asakura, M Kitakaze, S Sanada, H Asanuma, S Takashima, T Minamino, K Node, H Ogita, Y Asano, Y Shintani, L Yulin, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 299A - 300A, 英語

  研究発表ペーパー・要旨（国際会議）


• ACE inhibitors and angiotensin II receptor antagonists independently but synergistically increase coronary blood flow and attenuates the severity of contractile and metabolic dysfunction in ischemic hearts

  M Kitakaze, K Node, S Takashima, T Minamino, H Asanuma, M Asakura, J Kim, S Sanada, H Ogita, Y Asano, Y Shintani, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 288A - 288A, 英語

  研究発表ペーパー・要旨（国際会議）


• The selective estrogen receptor modulator, raloxifene, improves the severity of myocardial ischemia in canine hearts

  H Ogita, M Kitakaze, K Node, S Takashima, H Asanuma, M Asakura, S Sanada, Y Asano, Y Shintani, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 442A - 443A, 英語

  研究発表ペーパー・要旨（国際会議）


• Inhibitory effects of the novel antagonist of both GP IIb/IIIa and vitronectin receptors on the formation of coronary thromboemboli caused by an inhibition of adenosine receptors during coronary hypoperfusion in dogs

  H Asanuma, M Kitakaze, K Node, S Sanada, H Ogita, S Takashima, M Asakura, T Minamino, M Tada, M Hori

  2002年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 39(5) (5), 300A - 300A, 英語

  研究発表ペーパー・要旨（国際会議）


• The selective estrogen receptor modulator, raloxifene, reduces infarct size and ventricular arrhythmias in canine hearts

  H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, YL Liao, S Takashima, M Asakura, H Mori, Y Shinozaki, M Hori

  2001年10月, CIRCULATION, 104(17) (17), 150 - 150, 英語

  研究発表ペーパー・要旨（国際会議）


• Difference in the subcellular actions of ACE inhibitors and AT1 blockers on attenuating cardiac hypertrophy induced by chronic inhibition of nitric oxide synthesis in vivo

  S Sanada, T Sata, Y Sakata, S Takashima

  2001年10月, CIRCULATION, 104(17) (17), 190 - 190, 英語

  研究発表ペーパー・要旨（国際会議）


• The dihydropyridine Ca channel blocker, nifedipine, limits infarct size via bradykinin- and NO-dependent mechanisms in dogs

  M Kitakaze, Y Shinozaki, H Mori, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, 英語

  研究発表ペーパー・要旨（国際会議）


• Ischemia-selective early increase in nitric oxide synthesis confer acute cardioprotection against myocardial infarction afforded by pravastatin

  S Sanada, M Kitakaze, H Asanuma, S Takashima, K Node, H Ogita, M Asakura, YL Liao, T Kuzuya, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 363A - 363A, 英語

  研究発表ペーパー・要旨（国際会議）


• Amelioration of ischemia- and reperfusion-induced myocardial injury by raloxifene: Roles of nitric oxide and the opening of calcium-activated potassium channels

  H Ogita, M Kitakaze, K Node, H Asanuma, S Sanada, S Takashima, M Asakura, YL Liao, Y Shinozaki, H Mori, T Kuzuya, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 362A - 363A, 英語

  研究発表ペーパー・要旨（国際会議）


• A novel inhibitory effect of adenosine on cardiac hypertrophy

  M Asakura, M Kitakaze, S Takashima, S Higashiyama, Y Sakata, H Asanuma, S Sanada, H Ogita, YL Liao, K Node, T Toyofuku, T Kuzuya, M Tada, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 272A - 272A, 英語

  研究発表ペーパー・要旨（国際会議）


• Nitric oxide attenuates angiotensin II-induced activation of p70 S6 kinase and protein synthesis in rat cardiomyocytes via cyclic GMP-dependent mechanisms

  M Kitakaze, H Asanuma, S Sanada, M Asakura, H Ogita, YL Liao, K Node, S Takashima, T Kuzuya, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 294A - 295A, 英語

  研究発表ペーパー・要旨（国際会議）


• Heparin-binding EGF-like growth factor (HB-EGF) plays a critical role in the EGFR transactivation after angiotensin II stimulation in vascular smooth muscle cells

  M Asakura, M Kitakaze, S Takashima, S Higashiyama, H Asanuma, S Sanada, Y Sakata, H Ogita, YL Liao, T Toyofuku, T Kuzuya, M Tada, M Hori

  2001年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 37(2) (2), 270A - 270A, 英語

  研究発表ペーパー・要旨（国際会議）


• K+チャネル開口薬ニコランジルのNo-reflow現象抑制効果及び心筋梗塞縮小効果の検討

  浅沼博司, 北風政史, 真田昌爾, 高島成二, 野出孝一, 朝倉正紀, 扇田久和, 坂田泰彦, 葛谷恒彦, 多田道彦, 堀正二

  2001年, Therapeutic Research, 22, 698 - 700, 日本語

  [招待有り]

  記事・総説・解説・論説等（学術雑誌）


• アデノシンと心筋保護—プレコンディショニングとの関わり

  真田昌爾, 北風政史, 浅沼博司, 南野哲男, 野出孝一, 高島成二, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二

  2001年, 日本臨床生理学会雑誌, 31, 73 - 78, 日本語

  [招待有り]

  記事・総説・解説・論説等（学術雑誌）


• ニコランジル長期投与によりNO欠乏による慢性心肥大が血圧非依存性に抑制される—KATPチャネル開口がp70S6KとERKに及ぼす影響

  真田昌爾, 北風政史, 南野哲男, 野出孝一, 浅沼博司, 坂田泰彦, 朝倉正紀, 扇田久和, 葛谷恒彦, 堀正二

  2001年, Therapeutic Research, 22, 708 - 711, 日本語

  [招待有り]

  記事・総説・解説・論説等（学術雑誌）


• MX68, a new derivative of methotrexate, limits infarct size via adenosine-dependent mechanisms in dogs

  H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  2000年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 370A - 370A, 英語

  研究発表ペーパー・要旨（国際会議）


• Carvedilol limits infarct size via adenosine-dependent mechanisms in dogs

  H Asanuma, M Kitakaze, S Sanada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  2000年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 350A - 350A, 英語

  研究発表ペーパー・要旨（国際会議）


• Transient exposure of nicotine attenuates the severity of canine myocardial stunning via alpha(1)-adrenergic receptor activation and augmentation of ecto 5 '-nucleotidase activity

  S Sanada, M Kitakaze, H Asanuma, H Ogita, K Harada, S Takashima, Y Sakata, M Asakura, T Kuzuya, M Hori

  2000年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 369A - 369A, 英語

  研究発表ペーパー・要旨（国際会議）


• The effects of ischemic preconditioning on adenosine deaminase and kinase activities in the canine heart

  M Kitakaze, H Asanuma, S Sanada, S Takashima, Y Ueda, Y Sakata, M Asakura, H Ogita, T Kuzuya, M Hori

  2000年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 35(2) (2), 401A - 401A, 英語

  研究発表ペーパー・要旨（国際会議）


• Protein tyrosine kinase is not involved in the infarct size-limiting effect of ischemic preconditioning in canine hearts

  Masafumi Kitakaze, Koichi Node, Hiroshi Asanuma, Seiji Takashima, Yasuhiko Sakata, Masanori Asakura, Shoji Sanada, Yoshiro Shinozaki, Hidezo Mori, Tsunehiko Kuzuya, Masatsugu Hori

  2000年, Circ Res, 87, 303 - 308


• 細胞膜／ミトコンドリアATP感受性K+チャネルは相加的に心筋梗塞サイズ縮小効果を発揮する—麻酔開胸犬での検討

  真田昌爾, 北風政史, 浅沼博司, 扇田久和, 葛谷恒彦, 篠崎芳郎, 盛英三, 堀正二

  2000年, Therapeutic Research, 21, 785 - 788, 日本語

  [招待有り]

  記事・総説・解説・論説等（学術雑誌）


• Both sarcolemmal and mitochondrial ATP-sensitive potassium channels synergistically mimic the infarct size-limiting effect of ischemic preconditioning in the canine heart

  S Sanada, S Takashima, K Harada, Y Shinozaki, H Mori, M Kitakaze

  1999年11月, CIRCULATION, 100(18) (18), 717 - 717, 英語

  研究発表ペーパー・要旨（国際会議）


• Transient exposure to nicotine mediates the infarct size-limiting effect via activation of ecto-5'-nucleotidase. Role of alpha(1)-adrenoceptor activation.

  H Asanuma, S Sanada, H Mori, Y Shinozaki, T Kuzuya

  1999年11月, CIRCULATION, 100(18) (18), 838 - 838, 英語

  研究発表ペーパー・要旨（国際会議）


• Inhibition of p38 mitogen-activated protein kinase blunts the infarct size-limiting effect of ischemic preconditioning in the in vivo canine heart

  S Sanada, S Takashima, Y Sakata, M Asakura, N Terada

  1999年11月, CIRCULATION, 100(18) (18), 492 - 492, 英語

  研究発表ペーパー・要旨（国際会議）


• Increased membrane and soluble P-selectin in atrial fibrillation - Response

  T Minamino, M Kitakaze, S Sanada, H Asanuma, T Kurotobi, Y Koretsune, M Fukunami, T Kuzuya, N Hoki, M Hori

  1999年10月, CIRCULATION, 100(17) (17), E86 - E87, 英語

  速報，短報，研究ノート等（学術雑誌）


• 48)心嚢液貯留, 甲状腺機能異常を認め, 血清中に高分子Immunogloblinの過剰発現をみた大動脈炎症候群の1例

  木村 泰之, 高島 成二, 真田 昌爾, 森田 孝, 辻村 英一郎, 坂田 泰史, 山本 一博, 佐藤 洋, 葛谷 恒彦, 桑原 敬介, 寶學 英隆, 松本 昌泰, 堀 正二

  社団法人日本循環器学会, 1999年08月20日, Japanese circulation journal, 63(2) (2), 762 - 762, 日本語


• ATP感受性K^+チャネル開口による心筋梗塞縮小効果:分子メカニズムの検討

  北風 政史, 真田 昌爾, 浅沼 博司, 野出 孝一, 南野 哲男, 高島 成二, 中條 光章, 盛 英三, 葛谷 恒彦, 堀 正二

  1999年03月25日, 心電図 = Electrocardiology, 19(2) (2), 161 - 169, 日本語


• Prediction of paroxysmal atrial fibrillation in patients with congestive heart failure by P wave signal-averaged EGG: A prospective study.

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年10月, CIRCULATION, 98(17) (17), 441 - 441, 英語

  研究発表ペーパー・要旨（国際会議）


• Anatomical basis of QT dispersion in patients with dilated cardiomyopathy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano

  1998年10月, CIRCULATION, 98(17) (17), 441 - 441, 英語

  研究発表ペーパー・要旨（国際会議）


• 0048 I-123MIBG心筋イメージングによる慢性心不全患者の予後評価 : 前向き研究

  扇田 久和, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 1998年02月28日, Japanese circulation journal, 62(0) (0), 日本語


• 0385 心不全悪化の指標としての体表面加算平均心電図P波持続時間の有用性

  朝野 仁裕, 福並 正剛, 下永田 剛, 熊谷 和明, 山田 貴久, 真田 昌爾, 扇田 久和, 伯耆 徳武

  社団法人日本循環器学会, 1998年02月28日, Japanese circulation journal, 62(0) (0), 日本語


• 0387 失神患者におけるatrial early potentialによる洞不全症候群の検出

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 1998年02月28日, Japanese circulation journal, 62(0) (0), 日本語


• P071 慢性心不全患者におけるP波加算平均心電図による発作性心房細動の発症予測 : prospective study

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 1998年02月28日, Japanese circulation journal, 62(0) (0), 日本語


• P633 P波加算平均心電図の体表面マッピングによる発作性心房細胞発作に対するPilsicainideの再発予防効果予測

  山田 貴久, 福並 正剛, 下永田 剛, 熊谷 和明, 真田 昌爾, 扇田 久和, 朝野 仁裕, 伯耆 徳武

  社団法人日本循環器学会, 1998年02月28日, Japanese circulation journal, 62(0) (0), 日本語


• Dobutamine induced late potentials are related to the residual myocardial viability after acute myocardial infarction with reperfusion therapy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 447A - 447A, 英語

  研究発表ペーパー・要旨（国際会議）


• Detection of patients at risk for paroxysmal atrial fibrillation improved by body surface mapping of P-wave signal-averaged ECG

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, 英語

  研究発表ペーパー・要旨（国際会議）


• Prediction of efficacy or pilsicainide to paroxysmal atrial fibrillation by body surface mapping of the P-wave signal-averaged ECG: A prospective study

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 47A - 47A, 英語

  研究発表ペーパー・要旨（国際会議）


• Apoptosis of myocardial cell is associated with the abnormal signal-averaged ECG in patients with idiopathic dilated cardiomyopathy

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, 英語

  研究発表ペーパー・要旨（国際会議）


• Prediction of the effectiveness of long-term beta-blocker therapy for dilated cardiomyopathy by signal-averaged electrocardiography: A prospective study

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, S Sanada, H Ogita, Y Asano, N Hoki

  1998年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2) (2), 266A - 266A, 英語

  研究発表ペーパー・要旨（国際会議）


• A prospective study to predict the transition from paroxysmal atrial fibrillation to chronic atrial fibrillation by signal-averaged electrocardiography

  H Ogita, M Fukunami, T Shimonagata, K Kumagai, T Yamada, J Kim, S Sanada, N Hoki

  1997年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91218 - 91218, 英語

  研究発表ペーパー・要旨（国際会議）


• Reproducibility and long-term change of the P wave-triggered signal-averaged ECG

  T Yamada, M Fukunami, T Shimonagata, K Kumagai, J Kim, S Sanada, H Ogita, N Hoki

  1997年02月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 29(2) (2), 91213 - 91213, 英語

  研究発表ペーパー・要旨（国際会議）


• 拡張型心筋症化した非虚血性心不全と重症心室性不整脈に対しβ遮断薬が有効であった一例

  真田昌爾, 福並正剛, 下永田剛, 熊谷和明, 山田貴久, 扇田久和, 朝野仁裕, 伯耆徳武

  1997年, 診療と新薬, 34, 1267 - 1269, 日本語

  [招待有り]

  速報，短報，研究ノート等（学術雑誌）

• 乳酸シャトル・情報伝達障害としての緑内障性視神経症の病態論の提唱と治療法の探索

  中村 誠, 坂本 麻里, 楠原 仙太郎, 目黒 明, 盛 崇太朗, 真田 昌爾

  日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 2024年04月01日 - 2027年03月31日


• 職種特異的・横断的コアコンピテンシーの連携を活かした効率的な多職種協調型教育プログラムの作成と効果的な多職種共同臨床研究ワークショップの開発

  真田昌爾, 吉田寿子, 新谷歩, 浅田隆太, 清水忍, 岩崎幸司, 山口拓洋, 高田宗典, 松嶋由紀子, 菊地加代子, 西崎祐史, 出居真由美, 南学, 氏原淳

  国立研究開発法人日本医療研究開発機構, 医療研究開発推進事業費補助金 中央IRB促進事業, 大阪市立大学医学部附属病院, 2020年04月 - 2021年03月, 研究代表者


• Ｇ蛋白共役受容体とToll様受容体の特異的分子共役による心不全難治性化機転の解明

  真田 昌爾, 南野 哲男, 肥後 修一朗, 朝野 仁裕, 塚本 蔵

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 2013年04月01日 - 2016年03月31日

  本研究では従来の薬剤治療で予後が改善しない慢性心不全にて、自然免疫を担うIL-33／ST2 が新しいストレス応答依存機序として重症化に関与するか検討した。 心筋細胞にストレス刺激を加えると心筋肥大・アポトーシスが増加したが、IL-33はGPCR刺激で活性化されるNF-kBとJNK/p38に選択性を持ち、ST2と共役してそれらを強く抑制した。IL-33遺伝子改変マウスの圧負荷心不全モデルでも、IL-33の修飾が心筋肥厚・肺水腫・心筋収縮低下・炎症細胞浸潤・Th1/Th2サイトカインの発現変化・心筋線維化・心筋肥大に相関していた。 よってIL-33が慢性心不全の新たな治療標的となり得ることが示された。


• 次世代エピゲノム解析および超微細構造解析を応用した難治性心不全発症機序の解明

  朝野 仁裕, 肥後 修一朗, 塚本 蔵, 南野 哲男, 加藤 久和, 扇田 久和, 真田 昌爾

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 2012年04月01日 - 2015年03月31日

  臨床検体保存システムから得たヒト重症不全心筋細胞の細胞核ヘテロクロマチンの超微細構造解析を行った。画像解析と心不全可逆性マーカーの病理指標開発のため、クロマチン超微細構造の画像解析法を確立した。電子顕微鏡によりクロマチン構造を計測する本方法は、極めて高い感度特異度を示すこと、心エコー計測値、心臓線維化等の従来指標とは相関を示さない新しい計測値であることがわかった。 また、心不全病態遺伝子発現解析のみならず、蛋白分離精製技術を用い生化学的機序の解明と心臓生体試料のクロマチン免疫沈降法を開発し、心不全特異的エンハンサー領域を新規同定するとともに生体イメージング可能な心不全モデルマウスを作成した。


• 低酸素誘導性小胞体酸化還元酵素Ｅｒｏ１の心血管リモデリングにおける役割解明

  南野 哲男, 肥後 修一朗, 羽尾 裕之, 朝野 仁裕, 真田 昌爾, 塚本 蔵

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 2012年04月01日 - 2015年03月31日

  低酸素状態は虚血性心疾患や動脈硬化などの循環器疾患の病態形成に深く関与する。本研究では、低酸素誘導性小胞体酸化還元酵素Ero1の心血管リモデリングにおける役割を明らかするため、Gene trap ESクローンを用いて、Ero1遺伝子欠失マウスを作製した。興味深いことに、ヒト腹部大動脈サンプルを用いた免疫組織学的検討の結果、同疾患部位においてEro1発現が上昇していることを見いだした。そこで、Ero1遺伝子欠失マウスにアンジオテンシンIIを持続投与したところ、腹部大動脈瘤が形成されることを見いだした。Ero1は腹部大動脈形成に重要な役割をはたしていることが示唆された。


• ブタ心筋梗塞、心不全モデルでの腎動脈周囲高周波焼灼術による心機能改善効果の検討

  中谷 大作, 真田 昌爾, 小室 一成

  日本学術振興会, 科学研究費助成事業, 基盤研究(C), 大阪大学, 2012年04月01日 - 2014年03月31日

  平成25年度の研究実施計画は、ブタ左右腎動脈内に焼灼を実施し、6か月後の腎動脈および腎動脈周囲の傷害の程度を腎動脈造影および病理学的に評価を行うことである。また、腎動脈周囲の交感神経の傷害の程度を生理的に評価するために昇圧反応の有無からアデノシン（一般名：アデノシン三リン酸二ナトリウム）の至適投与量および投与方法の検討を行うことである。 これらを評価、検討するために、2頭のブタ腎動脈に対して、麻酔下に心臓用の不整脈焼灼カテーテルを用いて1頭目右腎動脈に12時方向を６W1分間、左腎動脈に12時方向を４W1分間、2頭目右腎動脈6時方向４W1分間、左腎動脈6時方向６W1分間にそれぞれ焼灼を行った。2頭とも左右腎動脈の近位部と遠位部に焼灼を行った。左右両腎動脈にアデノシンの急速動脈投与および、アデノシンの持続投与を焼灼6か月後にそれぞれ実施した。すべての手技が終了後、ブタを安楽死させ、腎動脈を摘出し、長軸方向に切開し、焼灼部位周辺部を組織固定した。6か月後、腎動脈造影上、いずれの血管においても狭窄像を認めなかった。ブタを安楽死させた直後に採取した腎動脈において、マクロ像として焼灼部位が白く瘢痕化していた（n=1）。組織標本については現在、作成中のため、今後評価予定。アデノシン10mgをゆっくりまたは急速に腎動脈内投与したところ、10秒後に5秒程度の昇圧反応が観察された。この反応は5mg、20mgの急速腎動脈内投与でも観察された。40mgを腎動脈内に急速投与すると5秒後に昇圧反応が観察されたが、その後、徐脈が出現。心臓に同薬剤が到達したために生じたと考えられた。2頭目の豚ではすべての用量においても昇圧反応は観察されなかった。両腎動脈ともアデノシン１γの持続投与により8分後より７～10mmHg程度の昇圧が観察されたが、アデノシン投与中止後も血圧は低下しなかった。


• 劇症型心筋炎の画期的診断法・治療法の開発

  南野 哲男, 真田 昌爾, 松崎 高志

  日本学術振興会, 科学研究費助成事業, 挑戦的萌芽研究, 大阪大学, 2011年 - 2011年

  劇症型心筋炎を呈する自己免疫性心筋炎の平均生存期間は4-12カ月であり、極めて予後不良である。生存率改善のためには、早期診断による早期治療の開始や新たな治療法の確立が期待される。本事業では、心筋炎部位での血管透過性が亢進し、ナノサイズ粒子が心臓に集積することを見出した。次に、免疫抑制剤FK506単独と比較して、リポソーム化したFK506は、劇症型心筋炎ラットモデルにおいて、心機能低下を著明に抑制することに成功した。リポソーム化免疫抑制剤は劇症型心筋炎に対する有効な治療法になることが期待できる。