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田根 慎也医学部附属病院 呼吸器外科講師
研究活動情報
■ 受賞- 2023年05月 European Society of Thoracic Surgeon, ESTS-JACS Award
- 2014年06月 EUROPEAN SOCIETY OF THORACIC SURGEONS, ESTS-GRILLO AWARD, BEST INOVETIVE/EXPERIMENTAL ABSTRACT国際学会・会議・シンポジウム等の賞
- BACKGROUND: With the widespread adoption of immune checkpoint inhibitors (ICIs) for advanced non-small cell lung cancer (NSCLC), local recurrence after immunotherapy has become increasingly frequent. However, limited evidence is available regarding salvage surgery after ICI therapy. METHODS: A multi-institutional retrospective study (CReGYT-05 Immune Checkpoint Inhibitor-Salvage Study) was conducted across 14 centers in Japan, evaluating patients who underwent salvage surgery after ICI therapy between 2016 and 2023. Salvage surgery was classified as conversion surgery (downstaging from initially unresectable to resectable disease) or true salvage surgery (surgery for local recurrence or residual disease). The primary endpoints included perioperative outcomes, overall survival (OS), and recurrence-free survival (RFS). RESULTS: The study analyzed 32 patients. Radiologic response to ICI therapy showed complete response in 4 patients (12.5 %), partial response in 23 patients (71.9 %), and stable disease in 5 patients (15.6 %). Salvage procedures comprised true salvage surgery (n = 17, 53.1 %) and conversion surgery (n = 15, 46.9 %). Lobectomy was performed for 84.4 % of the patients. Perioperative complications occurred in eight (25.0 %) of the patients, with no perioperative mortality. Pathologic complete response was achieved for six (18.8 %) patients. The 3- and 5-year OS rates from the initial diagnosis were 86.9 % and 77.2 %, respectively. Conversion surgery demonstrated superior 3-year RFS compared with true salvage surgery (92.8 % vs 36.3 %; p = 0.010). Univariable analysis identified salvage type as a significant factor for RFS. CONCLUSIONS: Salvage surgery after ICI therapy can be safely performed and is associated with encouraging survival outcomes for carefully selected patients, particularly those undergoing conversion surgery.2026年02月, Annals of surgical oncology, 英語, 国際誌研究論文(学術雑誌)
- Elsevier BV, 2026年01月, JTO Clinical and Research Reports, 7(1) (1), 100930 - 100930研究論文(学術雑誌)
- BACKGROUND: This real-world study aimed to investigate feasibility and profile of adverse events (AEs) associated with neoadjuvant chemoimmunotherapy in patients with resectable non-small cell lung cancer (NSCLC) in the real-world. METHODS: We conducted a multicenter retrospective study using real-world data of patients with resectable stage II-III NSCLC treated with neoadjuvant chemoimmunotherapy with nivolumab between March 2023 and July 2024 at 29 Japanese institutions. The safety, AE profiles, and risk factors for grade 3 or higher AEs were evaluated. RESULTS: A total of 126 patients were analyzed. In the neoadjuvant phase, grade 3 or higher treatment-related AEs and immune-related AEs (irAEs) occurred in 36 (28.6%) and 12 (9.5%) patients, respectively. One patient (0.8%) died from a neoadjuvant treatment-related AE of cytokine storm and subsequent multi-organ failure. Definitive surgery after neoadjuvant treatment was performed in 114 patients (90.5%), with only one death within 90 days of surgery. Half of endocrine-related irAEs occurred in the postoperative phase. Among the demographic characteristics, a history of coronary artery disease (CAD) was a significant risk factor for grade 3 or higher treatment-related AEs (odds ratio [OR] = 16.556, [95% confidence interval [CI] = 1.698-161.479], P = 0.016) and irAEs (OR = 10.196, [95% CI = 1.193-87.166], P = 0.034). CONCLUSIONS: Real-world data from the era of neoadjuvant chemoimmunotherapy showed feasibility consistent with the results of randomized controlled trials. The incidence of grade 3 or higher AEs was not particularly high but was clinically significant, and a history of CAD may be a predictor.2025年10月, The Annals of thoracic surgery, 英語, 国際誌研究論文(学術雑誌)
- 2025年09月, Annals of surgical oncology, 32(9) (9), 6203 - 6204, 英語, 国際誌
- OBJECTIVES: Intimal sarcoma is a rare vascular malignancy with a poor prognosis and no established treatment. This study aimed to identify clinicopathological and transcriptomic factors associated with disease progression to uncover potential therapeutic targets. METHODS: Ten patients with surgically resected intimal sarcoma were included. Ribonucleic acid (RNA) sequencing was performed on formalin-fixed, paraffin-embedded tumour samples, of which 8 passed quality control. Patients were stratified by the median overall survival of 17 months. Differentially expressed genes (DEGs) were identified and analysed using Gene Ontology (GO), Enrichr, and Gene Set Enrichment Analysis (GSEA). Immunohistochemistry was used to validate selected protein expression. RESULTS: The primary tumour site was the pulmonary artery in 8 cases and the heart in 2 cases. The median survival was 17 months, with a 5-year survival rate of 13.3%. Twenty-eight DEGs (|logFC| > 2, P < 0.01) were identified, most of which were upregulated in poor-prognosis tumours. GO and Enrichr analyses revealed enrichment in ribosome-related processes, including cytoplasmic translation and ribosomal biogenesis. GSEA showed enrichment of MYC targets and oxidative phosphorylation; epithelial-mesenchymal transition was moderately enriched, and myogenesis was downregulated. Immunohistochemistry confirmed overexpression of RPS27 and RPL26 in poor-prognosis tumours. CONCLUSIONS: Transcriptomic analysis revealed upregulation of ribosome-related genes in aggressive intimal sarcoma. Aberrant protein synthesis may contribute to poor prognosis and represent a novel therapeutic vulnerability.2025年08月, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 67(8) (8), 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVE: We developed a novel, noninvasive, extended reality-aided marking procedure for tumor localization and aimed to evaluate its feasibility and safety for sublobar resection in minimally invasive surgery. METHODS: We prospectively evaluated the concordance rate between extended reality-aided marking and actual tumor localization for 20 patients who underwent sublobar resection, including wedge resection and segmentectomy. During sublobar resection, the augmented reality image of the 3-dimensional pulmonary anatomy and the tumor were overlaid onto the thoracoscopic monitor. This allowed the surgeons to observe the tumor location with the head-mounted mixed reality display during the surgery. Marking concordance was defined as the difference of 10 mm or less between the distances from the actual tumor margin and the identified marking point on the extended reality to the margin. RESULTS: We enrolled 11 patients who underwent wedge resection and 9 patients who underwent segmentectomy. For each case, the pulmonary anatomy and tumor were successfully overlaid onto the operative image. The median computed tomography tumor size was 13.5 mm (interquartile range, 10.7-21.7 mm). The extended reality-aided marking method accurately delineated 90% of cases (18 of 20). The median distance from the actual surgical margin was 18 mm (interquartile range, 11-23.5 mm). The median duration of surgery was 117 (interquartile range, 64-147) minutes, and the perioperative courses were uneventful for all cases except for paroxysmal atrial fibrillation in 1 patient. CONCLUSIONS: Our novel, noninvasive, extended reality-based marking method is safe and feasible for identifying tumor locations during sublobar resection.2025年08月, JTCVS techniques, 32, 157 - 162, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: This study examined the learning curve of segmentectomy using the "fused surgery" approach. METHODS: We retrospectively collected data from 100 patients who underwent segmentectomy via fused robot-assisted thoracoscopy at our institution between September 2020 and February 2024. The learning curve was evaluated using the cumulative sum of the operative times in all cases and was analyzed separately for simple and complex segmentectomies. RESULTS: After applying the cumulative sum method to all cases, we obtained a graph of the operative time that showed three well-differentiated phases: phase 1 (n = 23), the initial learning phase; phase 2 (n = 28), the increased competence phase; and phase 3 (n = 49), the highest skill phase. Comparing phases 1 and 2 with phase 3, we found significant differences in operative time (P < 0.001); however, no significant differences were observed in bleeding or rate of postoperative complications. We observed a significant reduction in operative time after 25 simple segmentectomies and 22 complex segmentectomies. CONCLUSIONS: The data suggested that the inflection point of the learning curve was achieved in 51 cases. Complex segmentectomy requires the same cases to achieve the same level of competence as simple segmentectomy.2025年06月, Surgery today, 55(6) (6), 823 - 829, 英語, 国内誌研究論文(学術雑誌)
- PURPOSE: This study evaluated the efficacy of ninjin'yoeito for alleviating postoperative symptoms after lung cancer surgery. METHODS: Overall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin'yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function. RESULTS: The mean change in the CFS score 8 weeks postoperatively was - 5.56 in the ninjin'yoeito group and - 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were - 5.60 and - 3.38 in the ninjin'yoeito and conventional groups, respectively, with a difference of - 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were - 340.5 mL in the ninjin'yoeito group and - 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin'yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040). CONCLUSION: The results of this study show that ninjin'yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.2025年05月, Surgery today, 55(5) (5), 693 - 704, 英語, 国内誌研究論文(学術雑誌)
- OBJECTIVE: High-grade neuroendocrine carcinoma (HGNEC) with dominant POU2F3 expression exhibits non-neuroendocrine features. However, clinical data regarding this subset of pulmonary HGNECs are scarce, and its clinical characteristics remain unclear. METHODS: Clinicopathological data from 109 patients who underwent surgery for HGNEC were collected and analyzed based on transcription factor expression. Patients were divided into a POU2F3-dominant group (HGNEC-P) and a non-dominant group (HGNEC-non-P) according to immunohistochemical analysis. The clinicopathological characteristics of the two groups were compared, and univariate and multivariate analyses were conducted to identify prognostic factors. RESULTS: The HGNEC-P group comprised 26 patients, while the HGNEC-non-P group comprised 83 patients. The HGNEC-P group showed significantly lower expression of carcinoembryonic antigen (CEA) (p < 0.001) and a lower rate of vascular invasion (p = 0.021) compared to the HGNEC-non-P group. In addition, the HGNEC-P group exhibited a unique tumor marker profile, with lower serum CEA and higher serum cytokeratin antigen (CYFRA) levels (p < 0.001 and p = 0.046, respectively). Complete resection was achieved in all HGNEC-P cases, whereas only 75.9% of HGNEC-non-P cases achieved complete resection. Multivariate analysis identified POU2F3 expression as an independent prognostic factor for recurrence-free survival (RFS) and disease-specific survival (DSS) (p = 0.037 and p = 0.038, respectively). In patients with pathological Stage I disease, the HGNEC-P group showed significantly better RFS (p = 0.010). CONCLUSIONS: POU2F3-dominant HGNEC is associated with distinct clinicopathological features and favorable prognosis, particularly in early-stage disease. These findings may support the identification of this subset and inform the development of more effective treatment strategies.2025年04月, Cureus, 17(4) (4), e82758, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: The underlying mechanism why segmentectomy has demonstrated the non-inferiority to lobectomy in several randomized trials remains unclear. Computed tomography (CT)-measured pulmonary artery (PA) enlargement reflects PA pressure and predicts the prognosis of certain respiratory diseases. We compared the preoperative and postoperative PA diameter to the ascending aorta diameter (PA/A) ratio, investigating its impact on right ventricular function in lung resection. METHODS: This retrospective study was conducted in patients with lower-lobe lung tumors who underwent anatomical lung resection between 2017 and 2022. The PA diameter at the bifurcation and the ascending aorta diameter at the same CT image slice were measured preoperatively and postoperatively. We calculated the enlargement of PA/A ratio (PA/A change) and compared lobectomy and segmentectomy. RESULTS: This analysis included 279 patients (235 with lobectomy and 44 with segmentectomy). The PA/A change was significantly greater in patients with lobectomy than segmentectomy (104% vs. 102%, P = 0.02). In the multivariable analysis, airflow obstruction (yes, P = 0.04) and the type of surgery (segmentectomy, P = 0.04) were independent prognostic factors for PA/A change. CONCLUSIONS: The PA/A change was greater in lobectomy than in segmentectomy. This change could reflect a burden on right ventricular function after lobectomy.2025年, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 31(1) (1), 英語, 国内誌研究論文(学術雑誌)
- Blood oozing from the access port due to breakage of the wound protector may obscure the surgical view during thoracoscopic surgery. Therefore, we developed a novel wound protector with honeycomb meshing that prevents its breakage by dispersing the force acting on the edge of the access port in six directions. This novel wound protector could reduce the likelihood of interruption during surgery due to blood oozing from the surface of the access port, contributing to surgical efficacy and safety.2025年, Asian journal of endoscopic surgery, 18(1) (1), e70150, 英語, 国内誌研究論文(学術雑誌)
- PURPOSE: Given that left upper lobe and right upper and middle lobes share a similar anatomy, segmentectomy, such as upper division and lingulectomy, should yield identical oncological clearance to left upper lobectomy. We compared the prognosis of segmentectomy with that of lobectomy for early stage non-small-cell lung cancer (NSCLC) in the left upper lobe. METHODS: We retrospectively examined 2115 patients who underwent segmentectomy or lobectomy for c-stage I (TNM 8th edition) NSCLC in the left upper lobe in 2010. We compared the oncological outcomes of segmentectomy (n = 483) and lobectomy (n = 483) using a propensity score matching analysis. RESULTS: The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were comparable, irrespective of c-stage IA or IB. Subset analyses according to radiological tumor findings showed that segmentectomy yielded oncological outcomes comparable to those of lobectomy for non-pure solid tumors. In cases where the solid tumor exceeded 20 mm, segmentectomy showed a recurrence-free survival inferior to that of lobectomy (p = 0.028), despite an equivalent overall survival (p = 0.38). CONCLUSION: Segmentectomy may be an acceptable alternative to lobectomy with regard to the overall survival of patients with c-stage I NSCLC in the left upper lobe.2024年10月, Surgery today, 54(10) (10), 1162 - 1172, 英語, 国内誌研究論文(学術雑誌)
- PURPOSE: Robotic-assisted thoracoscopic surgery (RATS) is a relatively new approach to lung cancer surgery. To promote the development of RATS procedures, we investigated the factors related to short-term postoperative outcomes. METHODS: We analyzed the records of patients who underwent RATS lobectomy for primary lung cancer at our institution between June, 2018 and January, 2023. The primary outcome was operative time, and the estimated value of surgery-related factors was calculated by linear regression analysis. The secondary outcome was surgical morbidity and the risk was assessed by logistic regression analysis. RESULTS: The study cohort comprised 238 patients. Left upper lobectomy had the longest mean operative time, followed by right upper lobectomy. Postoperative complications occurred in 13.0% of the patients. Multivariate analysis revealed that upper lobectomy, the number of staples used for interlobular fissures, and the number of cases experienced by the surgeon were significantly associated with a longer operative time. The only significant risk factor for postoperative complications was heavy smoking. CONCLUSION: Patients with well-lobulated middle or lower lobe lung cancer who are not heavy smokers are recommended for the introductory period of RATS lobectomy. Improving the procedures for upper lobectomy and dividing incomplete interlobular fissures will promote the further development of RATS.2024年08月, Surgery today, 54(8) (8), 874 - 881, 英語, 国内誌研究論文(学術雑誌)
- 2024年08月, Annals of surgical oncology, 31(8) (8), 4849 - 4850, 英語, 国際誌
- PURPOSE: To evaluate the safety and efficacy of new staple-line reinforcement (SLR) in pulmonary resection through a prospective study and to compare the results of this study with historical control data in an exploratory study. METHODS: The subjects of this study were 48 patients who underwent thoracoscopic lobectomy. The primary endpoint was air leakage from the staple line. The secondary endpoints were the location of air leakage, duration of air leakage, and postoperative pulmonary complications. RESULTS: The incidence of intraoperative air leakage from the staple line was 6.3%. Three patients had prolonged air leakage as a postoperative pulmonary complication. No malfunction was found in patients who underwent SLR with the stapling device. When compared with the historical group, the SLR group had a significantly lower incidence of air leakage from the staple line (6.3% vs. 28.5%, P < 0.001) and significantly shorter indwelling chest drainage time (P = 0.049) and length of hospital stay (P < 0.001). CONCLUSIONS: The use of SLR in pulmonary resection was safe and effective. When compared with conventional products, SLR could control intraoperative air leakage from the staple line and shorten time needed for indwelling chest drainage and the length of hospital stay.2024年07月, Surgery today, 54(7) (7), 779 - 786, 英語, 国内誌研究論文(学術雑誌)
- In the last decade, even thoracic surgery has seen an increase in the use of robotic surgical systems, and robot-assisted thoracic surgery (RATS) is considered one of the main issues. While RATS is associated with solo manipulative freedom and high-definition optical systems, several disadvantages, such as the lack of tactile sensation and difficult learning curves for the whole team, have been raised. Therefore, to overcome these issues, we developed a 'fusion surgery' approach combining a robotic procedure with manual maneuvers, where the table surgeon retracts the lung and staples the pulmonary vasculature and bronchus. Herein, we introduce our 'fusion surgery' procedure and elaborate on its advantage from technical and educational perspectives.2023年12月, General thoracic and cardiovascular surgery, 71(12) (12), 730 - 732, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Evidence for the effects of immunotherapy in non-small cell lung cancer (NSCLC) patients with distant organ metastasis is insufficient, and the predictive efficacy of established markers in tissue and blood is elusive. Our study aimed to determine the prognostic factors and develop a survival prognosis model for these patients. METHODS: A total of 100 advanced NSCLC patients with distant organ metastases, who received single or combination immune checkpoint inhibitors (ICIs) in Xijing Hospital between June 2018 and June 2021, were enrolled for retrospective analysis. The major clinicopathological parameters were collected, and associated survival outcomes were followed up by telephone or inpatient follow-up for nearly 3 years to assess prognoses. The survival prognosis model was established based on univariate and multivariate Cox regression analyses to determine the candidate prognostic factors. RESULTS: From the start of immunotherapy to the last follow-up, 77 patients progressed and 42 patients died, with a median follow-up of 18 months [95% confidence interval (CI): 15-19.9]. The median progression-free survival (PFS) and overall survival (OS) were 8 months (95% CI: 5.6-10.4) and 21 months (95% CI: 8.9-33.1), respectively. Multivariate Cox proportional hazards analysis showed Eastern Cooperative Oncology Group performance status (ECOG PS), body mass index (BMI), age-adjusted Charlson comorbidity index (ACCI), lactate dehydrogenase (LDH), and absolute neutrophil count (ANC) were correlated significantly with OS. Based on these five predictive factors, a nomogram and corresponding dynamic web page were constructed with a concordance index (C-index) of 0.81 and a 95% CI of 0.778-0.842. Additionally, the calibration plot and time-receiver operating characteristic (ROC) curve validated the precision of the model at 6-, 12-, and 18-month area under the curves (AUCs) reached 0.934, 0.829, and 0.846, respectively. According to the critical point of the model, patients were further divided into a high-risk total point score (TPS) >258, middle-risk (204< TPS ≤258), and low-risk group (TPS ≤204), and significant OS differences were observed among the three subgroups (median OS: 4.8 vs. 13.0 vs. 32.9 months). CONCLUSIONS: A feasible and practical model based on clinical characteristics has been developed to predict the prognosis of NSCLC patients with distant organ metastasis undergoing immunotherapy.2023年10月, Translational lung cancer research, 12(10) (10), 2040 - 2054, 英語, 国際誌研究論文(学術雑誌)
- 胸部外科領域における周術期管理の重要ポイント II.呼吸器領域 8.合併症を有する患者の周術期水分・栄養管理の留意点The strategy for the administration of fluid and nutrition management after lung resection is not unusual, as compared to the other ordinal surgeries. However, it should be kept in mind that relative reduction in right ventricular function could occur following lung resection due to increased pulmonary vascular resistance. The surgical trauma such as pulmonary arterial clamp and lymphadenectomy as well as the removal of the lung, and perioperative factors such as single lung ventilation, could also increase pulmonary vascular resistance, all of which could be related to acute lung injury. Regarding the fluid management, excessive fluid administration could cause pulmonary edema, decreased alveolar gas permeability, atelectasis, and hypoxia, while restrictive fluid management could induce complication related to hypoperfusion. Since these adverse effects are highly associated with the main causes of morbidity and mortality particularly in the compromised patients, a proper assessment and monitoring of fluid balance (fluid optimization) would be required. In addition, along with the increasing number of the elderly patients, particular concerns must be given to the patients with the sarcopenia or frailty. The appropriate nutritional support following lung surgery is necessary to reduce surgical morbidity and morbidity especially for the malnourished and elderly patients.2023年09月, 胸部外科, 76(10) (10), 870 - 873, 日本語, 国内誌
- The left upper lobe is one of the largest lobes of the lung; left upper segmentectomy is well established among thoracic surgeons. In uniportal left S1 + 2 segmentectomy, dissection of the vasculature, bronchus, and intersegmental plane can be performed anteriorly. Given that the fissureless technique is commonly used in uniportal video-assisted thoracoscopic surgery, S1 + 2 segmentectomy exhibits high affinity with the unidirectional approach. We have frequently performed left S1 + 2 segmentectomy for early non-small cell lung cancer located in the apical segment, since this procedure has the potential to preserve pulmonary function over tri-segmentectomy. Herein, we introduce our approach to uniportal left S1 + 2 segmentectomy as a minimally invasive alternative for preserving lung function.2023年07月, General thoracic and cardiovascular surgery, 71(7) (7), 432 - 435, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Identifying the preoperative risk factors for lymph node upstaging could contribute to the development of individualized perioperative treatment for patients with non-small cell lung cancer (NSCLC). The current study aimed to evaluate the risk factors for lymph node upstaging, including gene mutation and programmed death ligand-1 expression in patients with resectable NSCLC. METHODS: Data on the clinicopathological characteristics of patients who underwent lobectomy for clinical N0 NSCLC at our institution were collected. The clinicopathological findings of the pathological N0 and lymph node upstaging groups were then analyzed. Univariate and multivariate analyses were performed to examine the predictive factors for nodal upstaging. RESULTS: Of 291 patients, 40 had postoperative nodal upstaging (n = 25, N1; n = 15, N2). Large tumor size and high maximum standardized uptake value were significantly associated with nodal upstaging. The nodal upstaging group had a higher proportion of patients with solid adenocarcinoma and lymphatic, vascular, and pleural invasion than the pathological N0 group. Further, the nodal upstaging group had a higher proportion of patients with positive programmed death ligand-1 expression than the pathological N0 group. Univariate and multivariate analyses showed that tumor size and positive programmed death ligand-1 expression were associated with nodal upstaging. CONCLUSION: The appropriate therapeutic strategy including preoperative treatment and resection should be cautiously considered preoperatively in patients with clinical N0 NSCLC who have large tumors and positive programmed death ligand-1 expression.2023年06月, Thoracic cancer, 14(18) (18), 1774 - 1781, 英語, 国際誌研究論文(学術雑誌)
- (NPO)日本気管食道科学会, 2023年04月, 日本気管食道科学会会報, 74(2) (2), s28 - s28, 日本語気管切開にて気管神経鞘腫を摘出した1例
- BACKGROUND: The advantages of segmentectomy over lobectomy in sparing pulmonary function remain controversial. Lower lobe segmentectomy is divided into simple segmentectomy, such as segment 6; and complex segmentectomy that includes the basal segments. Here, we compared residual lung function after thoracoscopic segmentectomy versus lobectomy in the lower lobe using the three-dimensional computed tomography volumetric method. METHODS: Between January 2012 and October 2020, 67 patients who underwent thoracoscopic segmentectomy of the lower lobe were matched to 67 patients who underwent thoracoscopic lower lobectomy during the same period using propensity score matching analysis. The postoperative decrease in the rate of forced expiratory volume in 1 s was compared between methods. The regional forced expiratory volume in 1 s of the residual lobe rescued by segmentectomy was measured using volumetric and spirometric analyses and compared to lower lobectomy. The ratio of the actual to predicted postoperative forced expiratory volume in 1 s in the residual lobe was defined as the preservation rate. RESULTS: Of the 67 thoracoscopic segmentectomies, 43 were S6, seven were S8, three were S8 + 9, seven were S10, and seven were S9 + 10. The percentage of postoperative/preoperative forced expiratory volume in 1 s was significantly higher in the segmentectomy versus lobectomy group (90.7% vs. 85.7%, p = 0.001). The preservation rates after simple segmentectomy (n = 43) and complex segmentectomy (n = 24) did not differ significantly (82.2% vs. 80.2%, p = 0.709). CONCLUSIONS: Thoracoscopic lower lobe segmentectomy versus lobectomy preserves postoperative lung function. Even complex segmentectomy exhibited outcomes relevant to simple segmentectomy by sparing the residual lobe.2023年03月, Asian cardiovascular & thoracic annals, 31(3) (3), 229 - 237, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: The left upper lobe is one of the largest lobes in the lungs and is divided into two anatomical units: the upper division (segments 1+2 and segment 3) and lingula (segments 4 and 5). This anatomical classification is similar to that used for the right upper and middle lobes. Although bilobectomy is not recommended for right upper or middle lobe tumors close to the interlobar plane, lobectomy is often performed for tumors located close to the intersegmental plane in the left upper division. To aid in establishing trisegmentectomy as a standard treatment for clinical N0 non-small cell lung cancer (NSCLC) in the left upper lobe, we aimed to re-assess its feasibility based on oncological outcomes according to tumor location. METHODS: We retrospectively analyzed the data of patients with clinical N0 NSCLC in the left upper division who underwent left upper lobectomy or trisegmentectomy between April 2006 and December 2020. After propensity score matching, oncological outcomes were compared between the trisegmentectomy and lobectomy groups. To verify whether trisegmentectomy was indicated regardless of tumor distance from the intersegmental plane, we compared the recurrence-free survival (RFS) rates following trisegmentectomy between patients with tumors ≤20 and >20 mm from the intersegmental plane. RESULTS: After propensity score matching, 46 patients were included in each group. There was no significant difference in the 5-year RFS rate between the lobectomy and trisegmentectomy groups (75.5% vs. 84.0%, P=0.41). In the trisegmentectomy cohort, the 5-year RFS rate did not significantly differ according to tumor distance from the intersegmental plane (≤20 or >20 mm) measured using three-dimensional computed tomography (79.4% vs. 81.2%, P=0.69). Multivariate analysis indicated that tumor distance from the intersegmental plane was not a significant predictor of RFS (hazard ratio: 1.75, 95% confidence interval: 0.52-5.91, P=0.37). CONCLUSIONS: Our analysis suggests that oncological outcomes (i.e., RFS rates) following trisegmentectomy for clinical N0 NSCLC in the left upper division are not significantly inferior to those following lobectomy, even if the tumor is located close to the intersegmental plane.2022年12月, Journal of thoracic disease, 14(12) (12), 4614 - 4623, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Two methods are available to identify the intersegmental plane during segmentectomy: the inflation-deflation method, based on the ventilation area, and injection of indocyanine green, based on the pulmonary arterial distribution. However, whether the intersegmental plane created by these 2 methods matches remains unknown. Our goal was to identify the demarcation lines based on bronchial and arterial territories using 3-dimensional computed tomography-based volumetry. METHODS: We collected data from patients who underwent thoracoscopic segmentectomy in our hospital between April 2012 and May 2021. Three-dimensional images were reconstructed from the preoperative contrast-enhanced computed tomography data using the SYNAPSE VINCENT software program. The volume of the affected area and the distance of the tumour from the intersegmental plane were calculated based on each affected artery and bronchus. Each calculated volume was compared to each affected segment using a paired t-test. RESULTS: Of 195 patients, 114 underwent upper lobe segmentectomy, and 81 underwent lower lobe segmentectomy. In upper lobe segmentectomy, the affected arterial segmental volume was smaller than the bronchial volume (505.0 ml vs 539.4 ml, P < 0.001). In lower lobe segmentectomy, there was no significant difference between arterial and bronchial volumes (234.6 ml vs 236.9 ml, P = 0.607). The volume of the affected arterial segmental lung and the distance of the tumour from the intersegmental plane were significantly smaller than the bronchial volume in upper lobe segmentectomies. CONCLUSIONS: As per the results, the affected segmental volume delineated by the indocyanine green method would be underestimated in upper lobe segmentectomy.2022年11月, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 62(6) (6), 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: The efficacy of segmentectomy for inner small-sized non-small-cell lung cancer (NSCLC) remains unknown. We aimed to elucidate whether segmentectomy for inner small-sized NSCLC, defined using a novel 3-dimensional measuring method, yields feasible oncologic outcomes compared with segmentectomy for outer lesions. METHODS: We retrospectively analyzed patients with small-sized (<2 cm) cN0 NSCLC who underwent segmentectomy between January 2007 and December 2020. The tumor centrality ratio, which was measured by using 3-dimensional reconstruction software, was evaluated. The location of tumor origin was confirmed pathologically. Cases with a ratio <2:3 and >2:3 were allocated to the inner group and outer group, respectively. Oncologic outcomes were compared between the 2 groups. RESULTS: Our cohort was divided into the inner group (n = 75) and outer group (n = 127). The proximal distance from a tumor was >20 mm in all cases. The tumor centrality ratio was associated with the pathologic origin of a tumor. The rate of unforeseen positive lymph node metastasis was significantly higher in the inner group (P = .04). There were no significant differences in the 5-year recurrence-free survival (91% vs 87%, P = .67). Univariate analysis identified age, consolidation/tumor ratio, the presence of ground-glass opacity, and lymphovascular invasion, but not tumor centrality, as significant prognostic factors for recurrence-free survival. In the multivariate analysis, the presence of ground-glass opacity and lymphovascular invasion remained significant. CONCLUSIONS: Regarding oncologic outcomes, segmentectomy with a safety proximal distance could be feasible, even for inner small-sized NSCLC. Tumor invasiveness, not tumor centrality, may influence tumor recurrence.2022年11月, The Annals of thoracic surgery, 114(5) (5), 1918 - 1924, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Although segmentectomy is an acceptable alternative to lobectomy for peripheral small-sized non-small-cell lung cancer, the effectiveness of segmentectomy for inner lesions remains unknown. The aim of this study was to examine the feasibility of segmentectomy in comparison with lobectomy for inner lesions. METHODS: We retrospectively analysed 570 patients with small (≤2 cm) cN0 non-small-cell lung cancer who underwent segmentectomy or lobectomy between January 2007 and March 2021. We focused on patients with lesions located in the inner two-thirds, which were determined using three-dimensional computed tomography (n = 227). After propensity score matching analysis based on sex, age, pulmonary function, serum carcinoembryonic antigen level, radiographic tumour findings and tumour location, we compared the surgical and oncological outcomes in patients who underwent segmentectomy (n = 66) and lobectomy (n = 66). RESULTS: Postoperative mortality or morbidity did not differ significantly between the 2 groups. The 5-year recurrence-free and overall survival rates in the segmentectomy and lobectomy groups were 93.6% vs 84.1% and 95.8% vs 87.9%, respectively. The differences between 2 groups were not significant (P = 0.62 and P = 0.23, respectively). The 2 groups also showed no differences in loco-regional recurrence. Multivariable Cox regression analysis revealed that segmentectomy had a comparable impact on recurrence-free survival (hazard ratio, 0.61; 95% confidence interval, 0.17-2.03; P = 0.43). CONCLUSIONS: Segmentectomy for inner-located small-sized non-small-cell lung tumours could be an acceptable treatment in comparison with lobectomy.2022年09月, Interactive cardiovascular and thoracic surgery, 35(4) (4), 英語, 国際誌研究論文(学術雑誌)
- Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is among the most fatal postoperative complications of lung resection in patients with IPF. Non-small-cell lung cancer (NSCLC) with IPF exhibits basal segment dominance. Treatment options for these lesions include lobectomy or basal segment segmentectomies. However, these procedures potentially increase risks of AE due to surgical stress including prolonged operative time and loss of pulmonary function. Therefore, as an alternative to these procedures, we developed a simple and practical deep wedge resection technique for basal segments. Our technique is minimally invasive and quick and simple approach in patients with NSCLC and IPF.2022年04月, General thoracic and cardiovascular surgery, 70(4) (4), 413 - 415, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: The clinical and prognostic implications of anaplastic lymphoma kinase (ALK) status in resected lung cancers remain unclear. In this study we analyzed the prognostic and predictive significance of ALK-positive among patients with completely resected lung adenocarcinoma. METHODS: We retrospectively reviewed 197 patients with lung adenocarcinoma who underwent complete surgical resection and had been tested for their ALK status. We investigated the impact of an ALK-positive status on the recurrence-free survival (RFS) and overall survival (OS) and examined the predictive factors for an ALK-positive status. RESULTS: ALK positivity was noted in 36 (18%) out of 197 patients, and when limited to stage I patients, in 24 (19%) out of 124. In the pathological-stage I population, while the OS exhibited no significant difference between ALK-positive and ALK-negative patients (5-year OS rate, 81.2% vs. 89.8%, p = 0.226), the RFS of ALK-positive patients was significantly worse than that of ALK-negative patients (5-year RFS rate, 55.9% vs. 78.8%, p = 0.018). A multivariate analysis showed that ALK-positive status (hazard ratio [HR] 3.431, p = 0.009) was an independent prognostic factor for the RFS. Regarding the relationship between clinicopathological factors and an ALK-positive status, a high-grade histological subtype, including solid and micropapillary subtypes (odds ratio [OR] 5.464, p < 0.001), and never-smokers (OR 4.292, p = 0.018) were associated with ALK-positive. CONCLUSION: A high-grade histological subtype and never-smokers were associated with ALK positivity, and the RFS of ALK-positive patients was worse than that of ALK-negative patients among patients with completely resected stage I lung adenocarcinoma.2022年04月, Thoracic cancer, 13(8) (8), 1109 - 1116, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Through 3-dimensional lung volumetric and morphological analyses, we aimed to evaluate the difference in postoperative functional changes between upper and lower thoracoscopic lobectomy. METHODS: A total of 145 lung cancer patients who underwent thoracoscopic upper lobectomy (UL) were matched with 145 patients with lung cancer who underwent thoracoscopic lower lobectomy (LL) between April 2012 and December 2018, based on their sex, age, smoking history, operation side, and pulmonary function. Spirometry and computed tomography were performed before and 6 months after the operation. In addition, the postoperative pulmonary function, volume and morphological changes between the 2 groups were compared. RESULTS: The rate of postoperative decreased and the ratio of actual to predicted postoperative forced expiratory volume in 1 s were significantly higher after LL than after UL (P < 0.001 for both). The tendency above was similar irrespective of the resected side. The postoperative actual volumes of the ipsilateral residual lobe and contralateral lung were larger than the preoperatively measured volumes in each side lobectomy. Moreover, the increased change was particularly remarkable in the middle lobe after right LL. The change in the D-value, representing the structural complexity of the lung, was better maintained in the left lung after LL than after UL (P = 0.042). CONCLUSIONS: Pulmonary function after thoracoscopic LL was superior to that after UL because the upward displacement and the pulmonary reserves of the remaining lobe appeared more robust after LL.2022年02月, Interactive cardiovascular and thoracic surgery, 34(3) (3), 408 - 415, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: We investigated the influence of the preoperative haemoglobin A1c (HbA1c) value on the prognosis and pathology of patients with lung adenocarcinoma who underwent surgery. METHODS: We reviewed the medical records of 400 lung adenocarcinoma patients who underwent lobectomy with mediastinal lymph node dissection between 2009 and 2013 using a prospectively maintained database. We stratified 400 patients into 4 groups according to the preoperative HbA1c value as follows: HbA1c ≤ 5.9 (n = 296), 6.0 ≤ HbA1c ≤ 6.9 (n = 70), 7.0 ≤ HbA1c ≤ 7.9 (n = 21) and HbA1c ≥ 8.0 (n = 12). We compared the recurrence-free survival and overall survival (OS) among these 4 groups. Univariate and multivariate analyses were performed to identify the risk factors for recurrence. RESULTS: The median follow-up period was 61.2 months. On comparing the recurrence-free survival and OS rates among these 4 groups, we found that these rates among patients in the HbA1c ≥ 8.0 group were significantly poorer compared with the other 3 groups (5-year recurrence-free survival: HbA1c ≤ 5.9, 70.4%; 6.0 ≤ HbA1c ≤ 6.9, 69.7%; 7.0 ≤ HbA1c ≤ 7.9, 70.7%; ≥8.0 HbA1c, 18.8%; P = 0.002; and 5-year OS: HbA1c ≤ 5.9, 88.7%; 6.0 ≤ HbA1c ≤ 6.9, 80.6%; 7.0 ≤ HbA1c ≤ 7.9, 90.2%; ≥8.0 HbA1c, 66.7%; P = 0.046). Patients in the HbA1c ≥ 8.0 group had significantly more tumours with vascular invasion (P = 0.041) and experienced distant metastasis significantly more often (P = 0.028) than those with other values. A multivariate analysis revealed that preoperative HbA1c ≥ 8.0 [hazard ratio (HR) 2.33; P = 0.026] and lymph node metastasis (HR 3.94; P < 0.001) were significant independent prognostic factors for recurrence. CONCLUSIONS: Our results revealed that preoperative HbA1c ≥ 8.0 is associated to poor prognosis due to the occurrence of distant metastasis and we should carefully follow these patients after surgery. CLINICAL REGISTRATION NUMBER: Hyogo Cancer Center, G-57.2021年10月, Interactive cardiovascular and thoracic surgery, 33(4) (4), 534 - 540, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Despite significant advances in surgical techniques, including thoracoscopic approaches and perioperative care, the morbidity rate remains high after lung resection. This study focused on a low attenuation cluster analysis, which represented the size distribution of pulmonary emphysema and assessed its utility for predicting postoperative pulmonary complications after thoracoscopic lobectomy. METHODS: From April 2013 to September 2018, lung cancer patients who received spirometry and computed tomography (CT) before surgery and underwent thoracoscopic lobectomy were included. The cumulative size distribution of the low attenuation area (LAA, defined as ≤-950 Hounsfield unit on CT) clusters followed a power-law characterized by an exponent D-value, a measure of the complexity of the alveolar structure. D-value and LAA% (LAA/total lung volume) were calculated using preoperative 3-dimensional CT software. The relationship between pulmonary complications and patient characteristics, including D-value and LAA%, was investigated. RESULTS: Among 471 patients, there were 61 respiratory complication cases (12.9%). Receiver operation characteristic curve analysis revealed that the best predictive cut-off value of D-value and LAA% for pulmonary complications was 2.27 and 16.5, respectively, with an area under the curve of 0.72 and 0.58, respectively. D-value was significantly correlated with % forced expiratory volume in 1 s. Per univariate analysis, gender, smoking history, forced expiratory volume in 1 s/forced vital capacity, LAA% and D-value were risk factors for predicting postoperative pulmonary complications. In the multivariate analysis, D-value remained a significant predictive factor. CONCLUSION: Preoperative assessment of emphysema cluster analysis may represent the vulnerability of the operated lung and could be the novel predictor for pulmonary complications after thoracoscopic lobectomy.2021年09月, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 60(3) (3), 607 - 613, 英語, 国際誌研究論文(学術雑誌)
- Cellular cannibalism is a tumor activity where a cell is engulfed by another cell. This process promotes tumor cell survival under unfavorable conditions. The current report describes an extremely rare case of thrombocytopenia resulting from cellular cannibalism in a patient with bone marrow metastasis due to malignant pleural mesothelioma (MPM). A 77-year-old male presented with hemothorax and thrombocytopenia. He was diagnosed with MPM of the sarcomatoid cell type. However, his disease progressed rapidly and he died 11 days after admission. Bone marrow aspiration revealed metastatic MPM cells that had engulfed other blood cells. Accordingly, the observed thrombocytopenia was attributed to cellular cannibalism by metastatic MPM tumor cells. To the best of our knowledge, this is the first reported case of thrombocytopenia due to cellular cannibalism in a patient with this type of malignancy (MPM). The results suggested that although MPM rarely metastasizes to the bone marrow, bone marrow aspiration could be useful in such cases.2021年08月, Molecular and clinical oncology, 15(2) (2), 163 - 163, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Pleural invasion (pl) is strongly associated with the pleural lavage cytology (PLC) status. We analysed tumours with pl and evaluated the relationship between the PLC status and pl. METHODS: We retrospectively reviewed 428 surgically treated patients who had been diagnosed with non-small-cell lung cancer with pl and had their PLC status examined between 2000 and 2016. We investigated the influence of a PLC-positive status on the prognosis and searched for the factors predictive of a PLC-positive status. RESULTS: Seventy-eight (18%) patients were PLC positive. The recurrence-free survival of PLC-positive patients was significantly worse than that of PLC-negative patients in pl1 and pl2, but not in pl3 (5-year recurrence-free survival rate, PLC positive versus PLC negative: pl1, 22.0% vs 60.0%, P = 0.002; pl2, 30.4% vs 59.7%, P = 0.015; pl3, 50.0% vs 59.6%, P = 0.427). A multivariable analysis showed that the degree of pl (pl2-3 versus pl1) [odds ratio (OR) 5.34, P < 0.001] was an independent predictive factor for PLC positivity. Epidermal growth factor receptor (EGFR) mutation positivity (OR 5.48, P = 0.042) and carcinoembryonic antigen (CEA) ≥5 ng/ml (OR 3.78, P = 0.042) were associated with a PLC-positive status in patients with pl2-3. We found that the PLC-positive rate in patients with pl2-3 was 35.6%; however, if the tumour was EGFR mutation positive and had CEA ≥5 ng/ml, the PLC-positive rate increased to 77%. CONCLUSIONS: If a tumour was suspected of being pl2-3 and had EGFR mutation positivity and CEA ≥5 ng/ml, the PLC-positive rate was extremely high. CLINICAL TRIAL REGISTRATION NUMBER: Hyogo Cancer Center, G-138.2021年04月, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 59(4) (4), 791 - 798, 英語, 国際誌研究論文(学術雑誌)
- EWSR1-CREM gene fusions were recently discovered in several mesenchymal and epithelial tumors, including myxoid mesenchymal tumors of the central nervous system, rare cases of soft tissue clear cell sarcoma and angiomatoid fibrous histiocytoma, and hyalinizing clear cell carcinoma, which implicates the potential phenotypic diversities of tumors harboring an EWSR1-CREM fusion. We herein present an exceedingly indolent pulmonary mesenchymal tumor showing distinctive clinicopathological features. This tumor histologically displayed a small nest and alveolar pattern consisting of monomorphic clear cells intermingled with dilated anastomosing vasculature. Immunophenotypically, tumor cells were positive for vimentin and focally positive for synaptophysin, but negative for many immunohistochemical panels including keratins, EMA, desmin, mesothelial markers, melanotic markers, smooth muscle actin, inhibin and S-100 protein. Interestingly, RNA sequencing identified an in-frame EWSR1-CREM fusion, which was confirmed by subsequent real-time/reverse transcription polymerase chain reaction and fluorescence in situ hybridization assay. Clinical follow-up showed no evidence of recurrence and metastasis. Our pathological findings further expand the phenotypic spectrum of tumors associated with EWSR1-CREM fusions, implying the emergence of a possible novel tumor entity.2020年12月, Pathology international, 70(12) (12), 1020 - 1026, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: The mammalian Notch family ligands delta-like 3 (DLL3) is reported to be a potential therapeutic target for large cell neuroendocrine carcinomas (LCNEC). The effect of DLL3 expression on LCNEC prognosis has not yet been elucidated. METHODS: We reviewed the medical records of 70 LCNEC patients undergoing surgical resection between 2001 and 2015 using a prospectively maintained database. We performed immunohistochemistry for DLL3 and investigated the correlation between the sensitivity of LCNEC to platinum-based adjuvant chemotherapy. RESULTS: DLL3 expression was positive in 26 (37.1%) LCNEC patients. A total of 23 patients (32.9%) received platinum-based adjuvant chemotherapy. Among patients with DLL3 expression-positive tumors, no difference was found in the five-year overall survival (OS) or recurrence-free survival (RFS) between patients with and without adjuvant chemotherapy (surgery + chemotherapy vs. surgery alone, five-year OS: 58.3% vs. 35.7% P = 0.36, five-year RFS: 41.7% vs. 35.7% P = 0.74). In contrast, among patients with DLL3-negative tumors, significantly greater five-year OS and RFS rates were observed for patients with adjuvant chemotherapy than for those without it (surgery + chemotherapy vs. surgery alone: five-year OS: 90.0% vs. 26.9% P<0.01, five-year RFS: 80.0% vs. 21.7% P < 0.01). A multivariate analysis for the RFS revealed that adjuvant chemotherapy was a significant independent prognostic factor among patients with DLL3-negative tumors (hazard ratio [HR]: 0.05, 95% confidence interval [CI]: 0.01-0.41, P < 0.01), although it was not a factor among patients with DLL3-positive tumors (HR: 0.73, 95% CI: 0.23-2.27, P = 0.58). CONCLUSIONS: Our results revealed that DLL3 is a predictive marker of sensitivity to platinum-based adjuvant chemotherapy for LCNEC. KEY POINTS: SIGNIFICANT FINDINGS OF THE STUDY: DLL3 was a predictive marker of sensitivity to platinum-based adjuvant chemotherapy for LCNEC. Among patients with DLL3 expression-negative LCNEC, platinum-based adjuvant chemotherapy significantly improved the OS and RFS, although it did not do so among patients with DLL3 expression-positive LCNEC. WHAT THIS STUDY ADDS: Our results suggest that DLL3 expression-positive LCNEC may be better treated with other types of adjuvant chemotherapy, such as the anti-DLL3 therapies if these effects are confirmed by ongoing clinical research.2020年09月, Thoracic cancer, 11(9) (9), 2561 - 2569, 英語, 国際誌研究論文(学術雑誌)
- OBJECTIVES: Segmentectomies such as S1 + 2, S1 + 2+3 and S4 + 5 segmentectomy are used to treat patients with non-small-cell lung cancer (NSCLC) in the left upper lobe. However, the preservable lung volume and changes after such segmentectomies remain unknown. We compared the residual pulmonary function after thoracoscopic segmentectomy or lobectomy in the left upper lobe and examined the efficacy of S1 + 2 segmentectomy regarding postoperative pulmonary function. METHODS: Patients with left upper lobe NSCLC who underwent thoracoscopic segmentectomy or lobectomy were included. Spirometry and computed tomography were performed before and 6 months after resection, and the ipsilateral preserved lobe volume was calculated using 3-dimensional computer tomography. The percentage of postoperative/preoperative forced expiratory volume in 1 s and actual/predicted regional forced expiratory volume in 1 s (preservation rate) in the residual lobe were compared. RESULTS: Eighty-eight patients underwent lobectomy and 70 patients underwent segmentectomy (23 S1 + 2, 35 S1 + 2+3 and 12 S4 + 5 segmentectomies). The percentage of postoperative/preoperative forced expiratory volume in 1 s was 97 in S1 + 2, 82 in S1 + 2+3, 86 in S4 + 5 segmentectomy and 73 in left upper lobectomy, indicating that segmentectomy could be a meaningful approach to preserve pulmonary function. The preservation rate was 83% in S1 + 2 and 62% in S1 + 2+3 segmentectomy and was significantly higher in S1 + 2 than in S1 + 2+3 segmentectomy (P < 0.001). CONCLUSIONS: Postoperative pulmonary function and the preservable lung volume of the residual lobe after thoracoscopic S1 + 2 segmentectomy were well-preserved among other segmentectomies and lobectomy. Thoracoscopic S1 + 2 segmentectomy is a good alternative for preserving postoperative function.2020年09月, Interactive cardiovascular and thoracic surgery, 31(3) (3), 331 - 338, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Compromised microvasculature resulting from disrupted bronchial arterial circulation appears to trigger chronic lung allograft dysfunction. Maintaining the microvasculature throughout the transplant process could improve the long-term health of transplanted lungs. We recently developed a bronchial-arterial-circulation-sparing (BACS) lung preservation approach and tested whether this approach would decrease microvascular damage and improve allograft function. METHODS: The lungs of Lewis rats were procured using either the BACS approach, where the bronchial and pulmonary arteries were synchronously perfused; a conventional approach, where only the pulmonary artery was perfused; or a conventional approach with a prostaglandin flush. After 4 hours of cold ischemia, physiologic function and vascular tone of the grafts were evaluated during ex vivo lung perfusion (EVLP), and microvasculature damage was assessed using 2-photon microscopy analysis. Lung function was compared after transplant among the groups. RESULTS: After 4 hours of cold ischemia, the BACS group exhibited significantly higher adenosine triphosphate levels and lower expression of phosphorylated myosin light chain, which is essential for vascular smooth muscle contraction. On EVLP, the BACS and prostaglandin groups showed lower pulmonary vascular resistance and less arterial stiffness. BACS attenuated microvasculature damage in the lung grafts when compared with conventional preservation. After transplantation, the lungs preserved with the BACS approach exhibited significantly better graft function and lower expression of phosphorylated myosin light chain. CONCLUSIONS: Our data suggest that BACS lung preservation protects the dual circulation inherent to the lungs, facilitating robust microvasculature in lung grafts after transplantation, leading to better posttransplant outcomes.2020年03月, Transplantation, 104(3) (3), 490 - 499, 英語, 国際誌研究論文(学術雑誌)
- A pneumatocele is a cystic change of the lung that is caused by a check valve in the bronchiole due to infection, trauma and positive-pressure ventilation. We herein report a case of pneumatocele triggered by using of continuous positive airway pressure (CPAP) for sleep apnea syndrome (SAS) after pulmonary resection. A 69-year-old man underwent right upper lobectomy for lung cancer and developed interstitial pneumonia (IP) 10th postoperative day (POD). He was treated with steroid pulse therapy (solmedrol 500 mg × 3 days), and thereafter with oral steroid therapy (predonin 30mg/day). Well responded to the steroid therapy, IP was improved. However, he noticed bloody sputum 29th POD, and chest computed tomography showed a giant cystic lesion on the dorsal right lower lobe. We resected the cyst and the pathological findings revealed that the cystic lesion was pneumatocele, and CPAP was strongly suspected of triggering this disease.2020年, Respiratory medicine case reports, 30, 101119 - 101119, 英語, 国際誌研究論文(学術雑誌)
- Rhabdomyosarcoma is a well-known neoplasm in children that frequently occurs in the extremities, the head and neck region, and the genitourinary tract. To the best of our knowledge, pulmonary primary rhabdomyosarcoma in adults is exceedingly rare, and few resected cases have been reported. We report a case of pulmonary primary rhabdomyosarcoma that was surgically resected then treated with adjuvant chemotherapy (vincristine, actinomycin-D and cyclophosphamide). At 9 months after surgery, the patient is free from disease. Although the prognosis of rhabdomyosarcoma is unfavorable, surgical resection and adjuvant therapy could be a potential treatment strategy for pulmonary primary rhabdomyosarcoma.2019年12月, General thoracic and cardiovascular surgery, 67(12) (12), 1089 - 1092, 英語, 国内誌研究論文(学術雑誌)
- 左後縦隔原発傍神経節腫切除A 69-year-old man with hypertension was referred for an abnormal shadow detected on chest computed tomography(CT) at a medical checkup. Enhanced CT showed a highly enhanced posterior mediastinal tumor of 34×27 mm. Magnetic resonance imaging (MRI) revealed a low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Thus, a neurogenic tumor was suspected and the surgery was performed. The tumor was carefully dissected as it was hyper-vascular and hemorrhagic. Immediately after tumor resection, the patient's blood pressure rapidly decreased, and phenylephrine hydrochloride was needed to maintain the blood pressure. The pathological diagnosis was paraganglioma.2019年12月, 胸部外科, 72(13) (13), 1072 - 1075, 日本語, 国内誌
- BACKGROUND: Segmentectomy has shown a beneficial effect on preserving lung function after resection. However, the preservable lung volume and changes after thoracoscopic segmentectomy remain unknown. We compared the residual lung function after thoracoscopic segmentectomy and lobectomy, using a novel three-dimensional computed tomography-based volumetric method. METHODS: Seventy-four patients who received thoracoscopic segmentectomy were matched to the 74 patients who received thoracoscopic lobectomy. Spirometry and computed tomography were performed before and 6 months after resection, and the ipsilateral residual preserved and nonoperated lobe volume and the contralateral lung volume were calculated using three-dimensional computed tomography. The percentage of actual/predicted regional forced expiratory volume in 1 second (the preservation rate) in each lobe (measured by volumetry and spirometry) was compared with the extent of resection and procedural difficulty (typical or atypical segmentectomy). RESULTS: The postoperative lung function was significantly more well preserved in segmentectomy than in lobectomy. After segmentectomy and lobectomy, the regional forced expiratory volume in 1 second of the ipsilateral unaffected lobe was increased in comparison with the preoperative value, whereas that of the residual lobe rescued by segmentectomy was decreased. The preservation rates of the residual and unaffected lobes were inversely and positively correlated, respectively, with the extent of the resected segment. The preservation rates of the residual lobe after typical or atypical segmentectomy were not significantly different. CONCLUSIONS: Although the decrease in the actual lung function of the residual lobe was greater than predicted and increased with increasing extent of resection, segmentectomy preserved the whole lung function better than lobectomy.2019年11月, The Annals of thoracic surgery, 108(5) (5), 1543 - 1550, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Large-cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC) are categorized as high-grade neuroendocrine carcinoma (HGNEC). We analyzed the efficacy of perioperative chemotherapy for HGNEC and the prognostic factors. METHODS: We retrospectively reviewed the medical records of patients who underwent tumor resection and were diagnosed with HGNEC between January 2001 and December 2014. The overall survival (OS) was estimated by the Kaplan-Meier method. Propensity score matching was performed to compare the OS between the treatment groups. Multivariate analyses using a Cox proportional hazards model were performed to search for prognostic factors for HGNEC. RESULTS: We analyzed 146 HGNEC patients (LCNEC n=92, SCLC n=54) without synchronous multiple cancers, who underwent complete resection. Seventy patients (LCNEC n=31, SCLC n=32) received perioperative chemotherapy and all of them received a platinum-based anticancer drug. Perioperative chemotherapy significantly improved the 5-year OS rates of HGNEC patients (all stages: 74.5% vs. 34.7%, P<0.01, stage I: 88.5% vs. 40.0%, P<0.01). The efficacy of perioperative chemotherapy was similar between LCNEC and SCLC patients [LCNEC all stages: hazard ratio (HR) 0.27, P<0.01, LCNEC stage I: HR 0.27, P=0.01; SCLC all stages: HR 0.38, P=0.02, SCLC stage I: HR 0.34, P=0.06]. The survival benefit of perioperative chemotherapy for HGNEC patients was confirmed by propensity score matching analysis (HR 0.31, P<0.01). The multivariate analysis revealed that perioperative chemotherapy (HR 0.29, P<0.01), sublobar resection (HR 2.11, P=0.04), and lymph node metastasis (HR 3.34, P<0.01) were independently associated with survival. CONCLUSIONS: Surgical resection combined with perioperative chemotherapy was considered to be effective even for stage I HGNEC patients. Sublobar resection might increase the risk of death in HGNEC patients.2019年04月, Journal of thoracic disease, 11(4) (4), 1145 - 1154, 英語, 国際誌研究論文(学術雑誌)
- Chronic allograft dysfunction (CLAD) remains a major complication, causing the poor survival after lung transplantation (Tx). Although strenuous efforts have been made at preventing CLAD, surgical approaches for lung Tx have not been updated over the last 2 decades. The bronchial artery (BA), which supplies oxygenated blood to the airways and constitutes a functional microvasculature, has occasionally been revascularized during transplants, but this technique did not gain popularity and is not standard in current lung Tx protocols, despite the fact that a small number of studies have shown beneficial effects of BA revascularization on limiting CLAD. Also, recent basic and clinical evidence has demonstrated the relationship between microvasculature damage and CLAD. Thus, the protection of the bronchial circulation and microvasculature in lung grafts may be a key factor to overcome CLAD. This review revisits the history of BA revascularization, discusses the role of the bronchial circulation in lung Tx, and advocates for novel bronchial-arterial-circulation sparing approaches as a future direction for overcoming CLAD. Although there are some already published review articles summarizing the surgical techniques and their possible contribution to outcomes in lung Tx, to the best of our knowledge, this review is the first to elaborate on bronchial circulation that will contribute to prevent CLAD from both scientific and clinical perspectives: from bedside to bench to bedside, and beyond.2018年08月, Transplantation, 102(8) (8), 1240 - 1249, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: The role of the circulating leukocytes in lungs and their relationship with circulating proinflammatory cytokines during ischemia-reperfusion injury is not well understood. Using ex vivo lung perfusion (EVLP) to investigate the pathophysiology of isolated lungs, we aimed to identify a therapeutic target to optimize lung preservation leading to successful lung transplantation. METHODS: Rat heart-lung blocks were placed on EVLP for 4 hours with or without a leukocyte-depleting filter (LF). After EVLP, lung grafts were transplanted, and posttransplant outcomes were compared. RESULTS: Lung function was significantly better in lung grafts on EVLP with a LF than in lungs on EVLP without a LF. The interleukin (IL)-6 levels in the lung grafts and EVLP perfusate were also significantly lower after EVLP with a LF. Interestingly, IL-6 levels in the perfusate did not increase after the lungs were removed from the EVLP circuit, indicating that the cells trapped by the LF were not secreting IL-6. The trapped cells were analyzed with flow cytometry to detect apoptosis and pyroptosis; 26% were pyroptotic (Caspase-1-positive). After transplantation, there was better graft function and less inflammatory response if a LF was used or a caspase-1 inhibitor was administered during EVLP. CONCLUSIONS: Our data demonstrated that circulating leukocytes derived from donor lungs, and not circulating proinflammatory cytokines substantially impaired the quality of lung grafts through caspase-1-induced pyroptotic cell death during EVLP. Removing these cells with a LF and/or inhibiting pyroptosis of the cells can be a new therapeutic approach leading to long-term success after lung transplantation.2017年12月, Transplantation, 101(12) (12), 2841 - 2849, 英語, 国際誌研究論文(学術雑誌)
- 2017年07月, The Annals of thoracic surgery, 104(1) (1), 370 - 370, 英語, 国際誌
- Ex vivo lung perfusion (EVLP) promises to be a comprehensive platform for assessment, reconditioning, and preservation of donor lungs and has been dramatically changing the face of clinical lung transplantation. Besides its increasing role in lung transplantation, EVLP has also been recognized as a useful tool for translational research involving the lungs. Based on recent remarkable evidence and experience using EVLP in lung transplantation, there is growing interest in, and expectations for, the use of EVLP beyond the field of lung transplantation. By combining EVLP with advances in regenerative medicine, stem cell biology, and oncology, the evolving technology of EVLP has tremendous potential to advance pulmonary medicine and science. In this review, we revisit recent advances in EVLP technology and research and discuss the future translation of EVLP applications into life-changing medicine.2017年06月, Chest, 151(6) (6), 1220 - 1228, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Accumulating evidence supports an increasing role of ex vivo lung perfusion (EVLP) in clinical lung transplantation. However, EVLP has adverse effects on the quality of lung grafts, which have rarely been discussed. Careful optimization of current EVLP protocols might improve outcomes. This study examined effects of different levels of oxygenation of the perfusate circulated through the lungs during EVLP and the impact on post-transplant functional outcomes. METHODS: We compared results of 4 different oxygenation levels in the perfusate during EVLP: 6% oxygen (O2), 40% O2, 60% O2, and 100% O2. We evaluated lung function, compliance, and vascular resistance and levels of glucose and other markers in the perfusate. After EVLP, lung grafts were transplanted, and post-transplant outcomes were compared. RESULTS: Lungs perfused with 40% O2 on EVLP had the lowest glucose consumption compared with the other perfusates. Lungs treated with 40% O2 or 60% O2 exhibited significantly less inflammation, as indicated by reduced pro-inflammatory cytokine messenger RNA levels compared with lungs perfused with 6% O2 or 100% O2. Significantly more oxidative damage was noted after 4 hours of EVLP perfused with 100% O2. After transplantation, lungs perfused with 40% O2 during EVLP had the best post-transplant functional outcomes. CONCLUSIONS: Optimization of O2 levels in the perfusate during EVLP improved outcomes in this rat model. Deoxygenated perfusate, the current standard during EVLP, exhibited significantly more inflammation with compromised cellular metabolic activity and compromised post-transplant outcomes.2017年04月, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 36(4) (4), 466 - 474, 英語, 国際誌研究論文(学術雑誌)
- Psf3 is a prognostic biomarker in lung adenocarcinoma: a larger trial using tissue microarrays of 864 consecutive resections.OBJECTIVES: Partner of Sld five (Psf) 3 is a member of the evolutionarily conserved heterotetrameric complex GINS (Go-Ichi-Ni-San). We previously reported that Psf3 could serve as a biomarker of poor prognosis in lung adenocarcinoma. Here, we used tissue microarrays to analyse Psf3 expression in lung adenocarcinoma and investigated whether its expression is associated with survival outcomes. METHODS: The study included 864 consecutive patients with lung adenocarcinoma who underwent complete resection at Hyogo Cancer Center between January 2002 and December 2009. Tissue microarrays were prepared, and Psf3 was detected using mouse antihuman Psf3 primary monoclonal antibodies. The status of Psf3 expression was determined using these microarrays. RESULTS: Of the 864 patients, 375 had high-positive Psf3 expression and 489 had low-positive expression. Psf3 expression was significantly associated with age, sex, T factor, lymph node metastasis, stage and P factor. The 5-year disease-free survival (DFS) rate was significantly lower in patients with high-positive Psf3 expression than in those with low-positive expression, and Psf3 expression, sex, age, T factor and lymph node metastasis were identified as independent and significant prognostic determinants. Among patients with Stage I adenocarcinoma, the 5-year DFS rate was significantly lower in those with high-positive Psf3 expression than in those with low-positive expression, and Psf3 expression was the most powerful survival predictor. CONCLUSIONS: The present findings strengthened our previous data demonstrating that high Psf3 expression in primary lung adenocarcinoma plays an important role in disease progression and is a prognostic indicator, particularly in early-stage adenocarcinoma.2016年10月, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 50(4) (4), 758 - 764, 英語, 国際誌研究論文(学術雑誌)
- Disturbance of the surgical view during video-assisted thoracic surgery (VATS) as a result of blood oozing from the wound surface of the access port may lead to additional stress on surgeons and is difficult to prevent. We used a wound edge protector with oxidized regenerated cellulose (ORC) rings for the wound surfaces of the access ports and eliminated the problem. Furthermore, no hemostatic procedure was required for the wound surface before wound closure because the ORC rings completely stopped wound surface bleeding during the operation. ORC rings enhanced protection of the thoracoscopic port and the quality of VATS.2016年02月, The Annals of thoracic surgery, 101(2) (2), 786 - 8, 英語, 国際誌研究論文(学術雑誌)
- 2015年11月, Cancer Sci, 106(11) (11), 1625 - 34, 英語[査読有り]研究論文(学術雑誌)
- AIM: We examined the advantages of thoracoscopy over thoracotomy in terms of perioperative outcomes and toleration of adjuvant chemotherapy. METHODS: Between April 2010 and March 2013, 657 patients with non-small-cell lung cancer who underwent lobectomy were classified into thoracoscopy (308 patients) and thoracotomy (349 patients) groups and compared. RESULTS: The thoracoscopy group had less blood loss compared to the thoracotomy group (p < 0.001). When limiting the analysis to pathological stage I patients, the results were similar (p < 0.001). In addition, the difference in blood loss between the 2 groups was greater in patients with severe pleural adhesions. The postoperative morbidity of the thoracoscopy group was significantly less than that of the thoracotomy group (13.3% vs. 21.2%, p < 0.001), and this result was similar when analyzing the pathological stage I patients (12.6% vs. 20.6%, p = 0.001). A higher percentage of the thoracoscopy group received both the full planned course and dose of adjuvant chemotherapy compared to the thoracotomy group (84.2% vs. 65.8%, p = 0.032). CONCLUSIONS: These results indicate that totally thoracoscopic lobectomy is the more beneficial surgical approach with regard to the incidence of postoperative complications and toleration of adjuvant chemotherapy.2015年10月, Asian cardiovascular & thoracic annals, 23(8) (8), 950 - 7, 英語, 国際誌研究論文(学術雑誌)
- Ruptured thymoma causing a hemothorax: A case report.A thymoma is a neoplasm that arises from the epithelial cells of the thymus, and may cause various signs and symptoms dependent upon its local extent. A non-traumatic hemothorax is extremely rare. The present study reports the case of a 77-year-old female who presented with an acute onset of chest pain. Imaging procedures revealed a mass occupying the anterior mediastinum and left hemithorax, and a left pleural effusion. Progressive anemia was noted following admission. Left hemothorax due to rupture of the anterior mediastinal mass was suspected, and emergency surgery was performed. Hemorrhage was observed on the cut surface of the tumor. An analysis of frozen sections indicated a thymoma, and a thymo-partial thymectomy was subsequently performed to remove as much of the hematoma as possible. The patient was discharged on post-operative day 13 following an uneventful recovery. The present case suggests that in previously healthy individuals, sudden-onset dyspnea and chest pain co-occurring with an acute widening of the mediastinum observed on roentgenograph may be indicative of a ruptured thymoma.2015年09月, Oncology letters, 10(3) (3), 1810 - 1812, 英語, 国際誌研究論文(学術雑誌)
- (NPO)日本肺癌学会, 2015年08月, 肺癌, 55(4) (4), 317 - 317, 日本語肺炎症性偽腫瘍の1切除例
- 2015年07月, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 48(1) (1), 77 - 82, 英語[査読有り]研究論文(学術雑誌)
- Pleural lavage cytology as an independent prognostic factor in non-small-cell lung cancer patients with stage I disease and adenocarcinomaWe previously reported that cancer cells may be detected through pleural lavage cytology (PLC). In this study, we sought to re-examine the prognostic significance of the PLC status based on an extended dataset with an additional follow-up period. Pleural lavage following thoracotomy was cytologically examined in 1,317 consecutive patients who were diagnosed with NSCLC between 1987 and 2004 at the Thoracic Surgery Units of Kobe University Graduate School of Medicine and Hyogo Cancer Center. Among the investigated patients, 46 exhibited positive cytological findings. The prognosis of these patients was significantly worse compared to that of patients without positive PLC. Of the 844 pathological stage I patients, 18 had a positive PLC status and their prognosis was significantly worse compared to that of patients with stage I disease without positive PLC. In conclusion, positive PLC findings were associated with a poor prognosis and this finding was significant for patients with stage I disease. These results suggest the need for PLC status evaluation during staging and treatment planning in patients with NSCLC.2015年01月, Mol Clin Oncol, 3(1) (1), 244 - 248, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- 2014年09月, ONCOLOGY LETTERS, 8(3) (3), 1017 - 1024, 英語[査読有り]研究論文(学術雑誌)
- 2014年08月, 日本気胸・嚢胞性肺疾患学会雑誌, 14(2号) (2号), 162, 日本語胸腔鏡下自然気胸手術をより確実なものにするためのダブルレイヤー法の検討[査読有り]
- 2014年03月, 日本外科学会雑誌, 115(臨増2) (臨増2), 224, 日本語本邦におけるNET治療の実態 診療ガイドラインへの展開 肺神経内分泌癌に対する手術症例の臨床的検討[査読有り]
- 2014年03月, 日本外科学会雑誌, 115(臨増2) (臨増2), 435, 日本語NOS(not otherwise specified)の臨床的意義について[査読有り]
- 2014年03月, 日本外科学会雑誌, 115(臨増2) (臨増2), 639, 日本語高齢者非小細胞肺癌に対する外科治療成績[査読有り]
- 2013年12月, Interact Cardiovasc Thorac Surg, 17(6) (6), 974 - 80, 英語[査読有り]研究論文(学術雑誌)
- Nectin-like molecule-5 (Necl-5) is an immunoglobulin-like molecule that was originally identified as a poliovirus receptor and is often upregulated in cancer cells. It has been said that Necl-5 plays a role in not only cell-cell adhesion, but also cell migration, proliferation, and metastasis. In this study, we used a bronchioloalveolar carcinoma (BAC) cell line and fibroblasts to assess the expression of Necl-5 in the development of cancer-stroma communication by using an easy-to-prepare double-layered collagen gel hemisphere (DL-CGH) system that enables visualization of cell migration during invasion. The expression of Necl-5 was higher in BAC cells than in fibroblasts. This tendency didn't change even when the BAC cells were mixed with fibroblasts. To assess the role of Necl-5 in the invasive activity of the BAC cells, we knocked down its expression using RNA interference (RNAi). The invasion assay with DL-CGH revealed that inhibition of Necl-5 expression in the BAC cells was associated with suppressed invasiveness. In addition, Necl-5 knockdown inhibited the movement and proliferation of the BAC cells. Necl-5 expression in lung cancer cells is crucial for their invasiveness in the cancer-stromal interaction, suggesting that Necl-5 could be a favorable molecular target for the suppression of invasiveness in lung adenocarcinoma.2013年04月, Experimental and molecular pathology, 94(2) (2), 330 - 5, 英語, 国際誌研究論文(学術雑誌)
- 2013年01月, Lung Cancer, 79(1) (1), 77 - 82, 英語[査読有り]研究論文(学術雑誌)
- Ewing's sarcoma family tumors (ESFT), which include Ewing's sarcoma and primitive neuroectodermal tumors (PNET), have been reported to originate in a variety of sites, mostly in the extremities. Previous reports have shown ESFT originating in the thoracic region, such as chest wall and peripheral lung. We herein report the first case of the ESFT that originated in the main bronchus. Endobronchial snare resection was followed by five courses of chemotherapy (VDC-IE; including vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide) and sequential radiation. After the treatment, the patient's condition has improved, and he has remained disease-free for the past year.2012年11月, Thoracic cancer, 3(4) (4), 353 - 356, 英語, 国際誌研究論文(学術雑誌)
- 2012年10月, 肺癌, 52(5号) (5号), 810, 日本語ALK染色陽性肺腺癌の術前診断の可能性
- 2012年03月, 兵庫県医師会医学雑誌, 54(2号) (2号), 58, 日本語原発性肺癌の肺門部気管支血管周囲組織浸潤と再発、予後に関する検討
- 症例は34歳,男性.右頚部の腫脹,疼痛を主訴に受診したところ,右頚部から胸腔内におよび上縦隔を左側に圧排する巨大な腫瘍を指摘された.生検にてsolitary fibrous tumorが疑われ,手術目的に入院となった.手術は耳鼻咽喉科と共同にて施行した.modified hemi-clamshell incisionにてアプローチし,腫瘍摘出術および右鎖骨下動脈再建術を施行した.第5,7,8頚椎椎間孔周囲の腫瘍は神経温存のため不完全切除とした.病理組織診ではdesmoid tumorと診断された.腫瘍残存部には術後放射線療法を施行し,術後1年を経過した時点で再発を認めていない.The Japanese Association for Chest Surgery, 2011年11月, 日本呼吸器外科学会雑誌 = The journal of the Japanese Association for Chest Surgery, 25(7) (7), 732 - 735, 日本語
- (NPO)日本肺癌学会, 2011年10月, 肺癌, 51(5) (5), 543 - 543, 日本語術前3D-CT肺血管把握における320列Area detector CTの有用性に関する検討
- Angiosarcoma is a rare neoplasm, accounting for only 1%-2% of all sarcomas. It occurs most frequently in the skin and soft tissue and rarely in the thoracic region. To our knowledge, a mediastinal angiosarcoma is extremely rare. We report on the surgical resection of a rare case of giant epithelioid angiosarcoma originating in the anterior mediastinum, followed by six courses of adjuvant chemotherapy (doxorubicin + ifosfamide). The patient is alive and asymptomatic 1 year after surgery. As the prognosis for unresectable cases is generally dismal, surgical resection and adjuvant therapy can be an option for mediastinal angiosarcoma.2011年07月, General thoracic and cardiovascular surgery, 59(7) (7), 503 - 6, 英語, 国内誌研究論文(学術雑誌)
- (NPO)日本肺癌学会, 2011年04月, 肺癌, 51(2) (2), 147 - 148, 日本語空洞形成を呈したrhabdoid形質を伴う肺大細胞癌の1例
- Malignant pleural mesothelioma (MPM) has a poor prognosis and is a treatment resistant tumor, which is increasing in frequency throughout the world. The poor prognosis is due to the aggressive local invasiveness rather than distant metastasis. In this study, we established a cell line of malignant mesothelioma from a clinical specimen and assessed the relationship between the expression of MT1-MMP and the invasion ability of that line, as well as the cultured cells of several other lines, using the simple method that we created previously. We established a cell line from a clinical specimen from a patient with malignant mesothelioma. We assessed the invasive activities of MPM cells in an easy-to-prepare double-layered collagen gel hemisphere (DL-CGH) system that enabled us to visualize cell movements during invasion. To assess the role of MT1-MMP in the invasive activity of MPM cells, we knocked down its expression by RNA interference (RNAi). The invasion assay with DL-CGH revealed that a high expression of MT1-MMP in MPM cells was associated with aggressive invasive activity. The RNAi of MT1-MMP indicated that the expression of MT1-MMP might have a crucial role in the invasiveness of MPM cells. The MT1-MMP expression in MPM cells is related to their capacity for locally aggressive spreading into the pleura and the surrounding tissues, and MT1-MMP should be a suitable molecular target for the suppression of the invasiveness of MPM.2011年02月, Experimental and molecular pathology, 90(1) (1), 91 - 6, 英語, 国際誌研究論文(学術雑誌)
- 特定非営利活動法人 日本呼吸器内視鏡学会, 2011年, 気管支学, 33, S293, 日本語
- (NPO)日本肺癌学会, 2010年08月, 肺癌, 50(4) (4), 401 - 401, 日本語Stiff-Person症候群を合併した浸潤型胸腺腫の1切除例
- 日本気胸・嚢胞性肺疾患学会, 2025年08月, 日本気胸・嚢胞性肺疾患学会雑誌, 25(2) (2), 72 - 72, 日本語女性気胸の定義 当科における月経随伴性気胸に対する治療戦略
- (NPO)日本肺癌学会, 2025年06月, 肺癌, 65(3) (3), 210 - 210, 日本語
- (NPO)日本肺癌学会, 2025年06月, 肺癌, 65(3) (3), 211 - 212, 日本語
- (NPO)日本肺癌学会, 2025年06月, 肺癌, 65(3) (3), 215 - 215, 日本語
- (一社)日本呼吸器外科学会, 2025年05月, 日本呼吸器外科学会雑誌, 39(4) (4), 383 - 387, 日本語
- (一社)日本外科学会, 2025年04月, 日本外科学会定期学術集会抄録集, 125回, PD - 6, 日本語さらなる低侵襲を目指したロボット手術 ConsolerとBedside SurgeonによるUniportal fused RATS(Consoler and bedside surgeon fused Uniportal RATS)
- (一社)日本外科学会, 2025年04月, 日本外科学会定期学術集会抄録集, 125回, PS - 8, 日本語胸腔鏡手術における新しい創部プロテクターの開発
- (NPO)日本気管食道科学会, 2025年04月, 日本気管食道科学会会報, 76(2) (2), s38 - s38, 日本語結核性右主気管支狭窄に対しECMO下に狭窄部切除・再建を行った1例
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), PD1 - 2, 日本語低侵襲手術のゆく先 当科におけるhinotori手術導入の初期成績
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), O35 - 6, 日本語隣接臓器合併切除を伴う胸腺腫手術の治療成績の検討
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), O47 - 5, 日本語臨床病期I期solidな陰影の非小細胞肺癌 男女間で性質に違いがあるのか?
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), O49 - 2, 日本語Consoler and Bedside surgeon fused RATSにおける出血トラブルシューティング
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), O52 - 3, 日本語胸腔鏡手術における新しい創部プロテクターの開発
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), P1 - 4, 日本語局所進行肺癌に対するSalvage手術の検討
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), P8 - 10, 日本語切除可能臨床病期2-3期非小細胞肺癌に対する術前化学療法の有効性
- (一社)日本呼吸器外科学会, 2025年04月, 日本呼吸器外科学会雑誌, 39(3) (3), P25 - 4, 日本語敗血症性ショックを伴う重症有瘻性膿胸に対して集学的治療により救命し得た1例
- 2025年, 胸部外科, 78(1) (1)Reduced-port RATSの実際 2.単孔式RATS コンソーラーとbedside surgeonが協調して行う単孔式RATS
- 2025年, 日本ロボット外科学会学術集会プログラム・抄録集, 17thロボット支援下肺癌手術における右上縦隔郭清の有用性について
- 2025年, 日本呼吸器外科学会雑誌(Web), 39(4) (4)Transmanubrial approachにより安全に摘出できた異所性副甲状腺腫再発の1例
- 2025年, 日本胸腺研究会プログラム・抄録集(Web), 44th剣状突起下ロボット支援下胸腺摘出術における助手の役割
- 2025年, 関西胸部外科学会学術集会プログラム・抄録集, 68th巨大な嚢胞性前縦隔腫瘍に対する手術の工夫
- (株)南江堂, 2025年01月, 胸部外科, 78(1) (1), 39 - 43, 日本語
- (NPO)日本肺癌学会, 2024年12月, 肺癌, 64(7) (7), 958 - 958, 日本語
- (NPO)日本肺癌学会, 2024年12月, 肺癌, 64(7) (7), 958 - 958, 日本語
- (一社)日本胸部外科学会, 2024年11月, 日本胸部外科学会定期学術集会, 77回, LWS5 - 3, 日本語難治性気胸 難治性気胸に対する当科での手術戦略
- (一社)日本胸部外科学会, 2024年11月, 日本胸部外科学会定期学術集会, 77回, LDB1 - 1, 日本語胸壁悪性腫瘍の外科治療 胸壁浸潤肺癌に対する術前補助療法の有用性
- (NPO)日本肺癌学会, 2024年10月, 肺癌, 64(5) (5), 413 - 413, 日本語早期肺がんに対する外科治療 中枢発生肺癌に対する区域切除適応拡大は可能か? 発生部位からみた検討
- (NPO)日本肺癌学会, 2024年10月, 肺癌, 64(5) (5), 449 - 449, 日本語肺癌の周術期を対象とした人参養栄湯の並行群間比較試験
- (NPO)日本肺癌学会, 2024年10月, 肺癌, 64(5) (5), 483 - 483, 日本語AI(人工知能)を用いて測定した原発性肺癌の充実成分体積/腫瘍全体体積と予後の相関
- (NPO)日本肺癌学会, 2024年10月, 肺癌, 64(5) (5), 569 - 569, 日本語第一肋骨に発生したEwing肉腫に対しての一切除例
- 日本気胸・嚢胞性肺疾患学会, 2024年08月, 日本気胸・嚢胞性肺疾患学会雑誌, 24(2) (2), 72 - 72, 日本語若年者気胸 若年者自然気胸に対する当科の手術戦略
- (NPO)日本肺癌学会, 2024年06月, 肺癌, 64(3) (3), 240 - 241, 日本語
- (一社)日本外科学会, 2024年04月, 日本外科学会定期学術集会抄録集, 124回, SF - 3, 日本語呼吸器外科技術の継承におけるドライモデルとcadaver surgical trainingを応用した手術手技教育への取り組み
- (一社)日本外科学会, 2024年04月, 日本外科学会定期学術集会抄録集, 124回, PS - 5, 日本語肺動脈径から予測する肺切除術の右心負荷への影響について
- (一社)日本外科学会, 2024年04月, 日本外科学会定期学術集会抄録集, 124回, PS - 4, 日本語中枢発生肺癌は術後再発しやすいか? 発生部位からみた検討
- (NPO)日本気管食道科学会, 2024年04月, 日本気管食道科学会会報, 75(2) (2), s6 - s6, 日本語ロボット支援下肺葉切除術における短期成績関連因子についての検討
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), WS3 - 3, 日本語区域切除適応拡大の是非 腫瘍径21-30mm非小細胞肺癌の区域切除、葉切除の予後比較
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), PS5 - 7, 日本語Extended Reality技術を用いた肺の腫瘍位置同定についての探索的研究
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), O7 - 5, 日本語胸膜浸潤を伴う非小細胞肺癌における縮小手術の妥当性
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), O15 - 7, 日本語臨床病期NO非小細胞肺癌におけるリンパ節upstagingと遺伝子変異、PD-L1発現の検討
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), O25 - 3, 日本語原発性肺癌に対する胸腔鏡下とロボット支援下肺葉切除術における短期成績の比較
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), O27 - 1, 日本語ConsolerとTable SurgeonによるUniportal fused RATS
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), O63 - 5, 日本語肺切除術におけるインターシードの有用性
- (一社)日本呼吸器外科学会, 2024年04月, 日本呼吸器外科学会雑誌, 38(3) (3), MO1 - 8, 日本語術中IVRにて血流遮断を行いながら安全に切除できた先天性左内胸動脈・左下横隔膜動脈-肺動脈瘻の1例
- 2024年, 日本ロボット外科学会学術集会プログラム・抄録集, 16thロボット支援下複雑区域切除術の周術期成績~単純区域切除術との比較
- 2024年, 日本ロボット外科学会学術集会プログラム・抄録集, 16th当施設におけるRATS手術中のコンバージョンについて
- 2024年, 日本呼吸器外科学会総会(Web), 41st臨床病期N0非小細胞肺癌におけるリンパ節upstagingと遺伝子変異,PD-L1発現の検討
- 2024年, 日本胸腺研究会プログラム・抄録集(Web), 43rdロボット支援下手術で切除した胸腺MALTリンパ腫の1例
- 2024年, 肺癌(Web), 64(3) (3)高度肥満患者に対するロボット支援下胸腔鏡手術
- 2024年, 日本内視鏡外科学会総会(Web), 37thロボット支援下肺切除術における術中術後合併症の特徴とその改善策についての検討
- 2024年, 日本内視鏡外科学会総会(Web), 37th当科におけるロボット支援下複雑区域切除の実際
- 2024年, 日本内視鏡外科学会総会(Web), 37thロボット支援下肺区域切除術におけるラーニングカーブについての検討~当院における100例の検討から
- 2024年, 肺癌(Web), 64(7) (7)縦隔発生滑膜肉腫の1切除例
- 2024年, 関西胸部外科学会学術集会プログラム・抄録集, 67th (Web)切除不能EGFR陽性肺癌に対してオシメルチニブ治療後にサルベージ手術を行なった2症例
- 2024年, 関西胸部外科学会学術集会プログラム・抄録集, 67th (Web)ロボット支援下複雑区域切除術の周術期成績~当院における100例のロボット支援下区域切除術の経験から
- 2024年, 肺癌(Web), 64(7) (7)局所進行肺癌に対するSalvage手術の検討
- (一社)日本内視鏡外科学会, 2023年12月, 日本内視鏡外科学会雑誌, 28(7) (7), 2023 - 2023, 日本語肺癌に対するロボット支援手術の工夫とピットフォール ロボット支援下肺切除術における自動縫合器の使用法についての検討
- (一社)日本内視鏡外科学会, 2023年12月, 日本内視鏡外科学会雑誌, 28(7) (7), 2662 - 2662, 日本語肺癌手術におけるアプローチの選択-VATS,RATS,単孔式,それぞれの利点と欠点- 肺区域切除におけるロボット支援胸腔鏡手術の有用性
- (NPO)日本肺癌学会, 2023年10月, 肺癌, 63(6) (6), 897 - 897, 日本語
- (NPO)日本肺癌学会, 2023年10月, 肺癌, 63(5) (5), 374 - 374, 日本語グローバルスタンダードを目指した肺がん縮小手術開発の現状と課題 胸腔鏡下・ロボット支援下での肺癌縮小手術の現状と課題
- (NPO)日本肺癌学会, 2023年10月, 肺癌, 63(5) (5), 402 - 402, 日本語縮小手術のエビデンスを熟考する 左上葉肺癌臨床病期I期における区域切除の妥当性 第7次肺癌登録事業データベースを用いた研究
- (NPO)日本肺癌学会, 2023年10月, 肺癌, 63(5) (5), 481 - 481, 日本語肺動脈内膜肉腫に対し肺動脈内膜摘除術及び肺切除術を行った4例の検討
- (NPO)日本肺癌学会, 2023年10月, 肺癌, 63(5) (5), 566 - 566, 日本語ロボット支援下肺区域切除におけるステープリングの工夫
- (一社)日本胸部外科学会, 2023年10月, 日本胸部外科学会定期学術集会, 76回, LWS2 - 2, 日本語呼吸器外科学における医工連携 3DCT softwareの呼吸器外科学への応用
- (株)南江堂, 2023年09月, 胸部外科, 76(10) (10), 870 - 873, 日本語
- (一社)日本呼吸器内視鏡学会, 2023年09月, 気管支学, 45(5) (5), 358 - 358, 日本語高度肺気腫に合併した難治性気胸に集学的治療を行った1例
- (一社)日本集中治療医学会, 2023年06月, 日本集中治療医学会雑誌, 30(Suppl.1) (Suppl.1), S703 - S703, 日本語がん専門病院における呼吸ケアサポートチーム(RST)の活動評価
- (NPO)日本肺癌学会, 2023年06月, 肺癌, 63(3) (3), 255 - 255, 日本語
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), PD2 - 6, 日本語術後エアリークの予防と対策,難治性気胸の治療 当院で行なっている細気管支瘻を合併した難治性気胸に対するフィブリン糊・PGAシート充填術
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), O1 - 2, 日本語質の高いロボット支援下手術を教育していくにあたって Learning curveについての検討
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), O2 - 4, 日本語安全なロボット支援下胸腔鏡下手術の確立に向けて
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), O4 - 6, 日本語肺切除術の術式と右心負荷との関連 肺動脈径に焦点を当てて
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), O32 - 5, 日本語Polyglactin 910 and 2x polydioxanoneを用いたstaple-line補強材の肺切除における安全性・有効性評価
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), O50 - 3, 日本語安全な鏡視下手術・開胸手術の技術の両立を目指した教育法
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), P19 - 8, 日本語Transmanubrial approachにより摘出した異所性副甲状腺腫の1例
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), P30 - 6, 日本語CPRに伴う両側多発肋骨・肋軟骨骨折に対して有効であったPectus barを用いた胸郭固定術の1例
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), P92 - 7, 日本語前縦隔腫瘍に対する剣状突起下アプローチ法のロボット支援下手術の適応についての検討
- (一社)日本呼吸器外科学会, 2023年06月, 日本呼吸器外科学会雑誌, 37(3) (3), P100 - 3, 日本語uniportal VATSブラ切除術の若手術者修練における安全性
- (NPO)日本気管食道科学会, 2023年04月, 日本気管食道科学会会報, 74(2) (2), s83 - s83, 日本語右下葉肺癌CRT後に発生した異時性肺癌に対し胸腔鏡下右上葉切除を行った1例
- (一社)日本外科学会, 2023年04月, 日本外科学会定期学術集会抄録集, 123回, SF - 6, 日本語UFTによる術後補助化学療法中におけるCOVID-19ワクチンの効果と安全性に関する前向き観察研究
- (一社)日本外科学会, 2023年04月, 日本外科学会定期学術集会抄録集, 123回, DP - 6, 日本語ロボット支援下手術の利点を活かしたcomplex segmentectomy
- (一社)日本外科学会, 2023年04月, 日本外科学会定期学術集会抄録集, 123回, DP - 2, 日本語当大学における新たな開胸手術の教育・指導法
- 2023年, 肺癌(Web), 63(3) (3)間質性肺炎合併下葉肺癌に対して有用なDeep wedge resection technique
- 2023年, 肺癌(Web), 63(6) (6)ロボット支援下下葉複雑区域切除手技の定型化
- 2023年, 日本胸腺研究会プログラム・抄録集(Web), 42nd99mTcMIBI集積を認めた胸腺腫を合併した副甲状腺機能亢進症の1例
- 2023年, 関西胸部外科学会学術集会プログラム・抄録集, 66th巨大な胸腺上皮性腫瘍に対する術前治療についての検討
- 2023年, 関西胸部外科学会学術集会プログラム・抄録集, 66th自動縫合器による気管支切離の際のカテーテル合併切離症例の検討
- 2023年, 関西胸部外科学会学術集会プログラム・抄録集, 66th先天性気管支閉鎖症に対して外科的治療を行った2例
- (一社)日本内視鏡外科学会, 2022年12月, 日本内視鏡外科学会雑誌, 27(7) (7), 2225 - 2225, 日本語肺癌に対する低侵襲手術のエビデンス 原発性肺癌に対するロボット支援下手術のリンパ節郭清における意義についての検討
- (一社)日本内視鏡外科学会, 2022年12月, 日本内視鏡外科学会雑誌, 27(7) (7), 2691 - 2691, 日本語当院におけるロボット支援下縦隔腫瘍手術の適応についての検討
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 604 - 604, 日本語局所進行非小細胞肺癌に対するSalvage手術 Induction後手術との比較
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 615 - 615, 日本語肉腫型中皮腫に進展したmesothelioma in situの1例 MTAP lossおよびCDKN2Aホモ欠失と予後との関連
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 631 - 631, 日本語上葉発生・下葉発生非小細胞肺癌の予後の比較
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 742 - 742, 日本語末梢性肺腫瘤病変に対する肺部分切除におけるECHELON ENDOPATH Staple Line Reinforcementの使用経験
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 746 - 746, 日本語視神経脊髄炎スペクトラム障害を合併した胸腺非定型カルチノイドの1切除例
- (NPO)日本肺癌学会, 2022年11月, 肺癌, 62(6) (6), 763 - 763, 日本語転移した縦隔リンパ節が左上大静脈遺残に浸潤していた左上葉肺癌の一例
- (一社)日本胸部外科学会, 2022年10月, 日本胸部外科学会定期学術集会, 75回, LWS3 - 2, 日本語COPD合併肺癌の外科治療 術中リーク発生部位と手術成績
- (一社)日本胸部外科学会, 2022年10月, 日本胸部外科学会定期学術集会, 75回, LP7 - 1, 日本語難治性肺瘻に対するフィブリン糊・PGAシート充填術を行う際の工夫
- 日本気胸・嚢胞性肺疾患学会, 2022年08月, 日本気胸・嚢胞性肺疾患学会雑誌, 22(2) (2), 116 - 116, 日本語補強剤を用いた手術手技の工夫 若年気胸に対する最近の当科の治療戦略
- (一社)日本呼吸器外科学会, 2022年05月, 日本呼吸器外科学会雑誌, 36(Suppl.) (Suppl.), O77 - 6, 日本語3次元医用画像解析システムの肺区域切除への応用
- (一社)日本呼吸器外科学会, 2022年05月, 日本呼吸器外科学会雑誌, 36(Suppl.) (Suppl.), P28 - 1, 日本語肺動脈原発血管内膜肉腫の一切除例
- (一社)日本外科学会, 2022年04月, 日本外科学会定期学術集会抄録集, 122回, SF - 3, 日本語中枢発生小型肺癌に対する区域切除の妥当性 肺葉切除との比較
- (NPO)日本肺癌学会, 2021年10月, 肺癌, 61(6) (6), 510 - 510, 日本語
- (NPO)日本肺癌学会, 2021年10月, 肺癌, 61(6) (6), 711 - 711, 日本語間質性肺炎合併底区肺癌に対して行った有用な部分切除の方法(スリーポインテッドスター法)
- (一社)日本胸部外科学会, 2021年10月, 日本胸部外科学会定期学術集会, 74回, LOP4 - 3, 日本語中枢発生小型肺癌に対する区域切除の妥当性について
- (一社)日本呼吸器外科学会, 2021年05月, 日本呼吸器外科学会雑誌, 35(3) (3), RO2 - 3, 日本語VATSを用いた区域切除に関する、UniportalとMultiportalでのアプローチの比較(Uniportal vs Multiportal VATS segmentectomy)
- (一社)日本呼吸器外科学会, 2021年05月, 日本呼吸器外科学会雑誌, 35(3) (3), MO2 - 5, 日本語I期原発性肺腺癌における3D-volumetryから求めた糖代謝因子のoccult N2予測因子としての有用性
- (一社)日本呼吸器外科学会, 2021年05月, 日本呼吸器外科学会雑誌, 35(3) (3), MO57 - 7, 日本語左S1+2区域切除における3DCTを活用した区域容量解析 ICG静注法は正確に切除区域を反映するか?
- (一社)日本呼吸器外科学会, 2021年05月, 日本呼吸器外科学会雑誌, 35(3) (3), MO86 - 3, 日本語異時性多発肺癌に対する両側肺切除症例の検討
- (一社)日本呼吸器外科学会, 2021年05月, 日本呼吸器外科学会雑誌, 35(3) (3), MO97 - 4, 日本語外科的完全切除を施行したI期ALK陽性肺腺癌の臨床学的特徴
- (一社)日本外科学会, 2021年04月, 日本外科学会定期学術集会抄録集, 121回, SF - 5, 日本語胸腔鏡下上葉切除、下葉切除術後の呼吸機能変化
- (一社)日本内視鏡外科学会, 2021年03月, 日本内視鏡外科学会雑誌, 25(7) (7), WS6 - 2, 日本語胸腔鏡下手術において医工連携が果たす役割 3次元画像解析ソフトの呼吸器外科学への応用
- 2021年, 日本肺癌学会学術集会号(CD-ROM), 62nd癌オルガノイド培養の臨床応用に向けた当科の取り組み
- (NPO)日本肺癌学会, 2020年10月, 肺癌, 60(6) (6), 536 - 536, 日本語扁平上皮癌術後予後予測におけるFDG-PET視覚的評価の有用性
- (NPO)日本肺癌学会, 2020年10月, 肺癌, 60(6) (6), 549 - 549, 日本語85歳以上の超高齢者肺癌症例に対する手術の妥当性 周術期成績と予後の検討
- (NPO)日本肺癌学会, 2020年10月, 肺癌, 60(6) (6), 550 - 550, 日本語原発性肺腺癌occult N2症例に対するFDG-PETを用いた糖代謝因子の臨床的意義
- (一社)日本胸部外科学会, 2020年10月, 日本胸部外科学会定期学術集会, 73回, LPL4 - 2, 日本語胸腔鏡下左上葉切除、下葉切除術後の残存肺の変化
- (一社)日本胸部外科学会, 2020年10月, 日本胸部外科学会定期学術集会, 73回, LOO16 - 2, 日本語切除検体を用いた肺癌オルガノイド培養法の樹立
- (一社)日本外科学会, 2020年08月, 日本外科学会定期学術集会抄録集, 120回, SF - 6, 日本語3DCTクラスター肺気腫評価に基づく肺癌術後呼吸器合併症予測
- (一社)日本外科学会, 2020年08月, 日本外科学会定期学術集会抄録集, 120回, DP - 2, 日本語cN0左上葉肺癌に対するマージンを意識した左上区切除:左上葉切除との比較
- (一社)日本呼吸器外科学会, 2020年08月, 日本呼吸器外科学会雑誌, 34(3) (3), S - 1, 日本語肺移植から学ぶ呼吸器外科学 新しい肺保存法の開発、Ex Vivo Lung Perfusionの応用から紡ぐ呼吸器外科学の発展
- (一社)日本呼吸器外科学会, 2020年08月, 日本呼吸器外科学会雑誌, 34(3) (3), RO21 - 2, 日本語cN0左上葉肺癌に対するマージンを意識した左上区切除 左上葉切除との比較
- (一社)日本呼吸器外科学会, 2020年08月, 日本呼吸器外科学会雑誌, 34(3) (3), O7 - 1, 日本語病理学的胸膜浸潤を有する肺癌と洗浄胸水細胞診の関連についての検討
- (一社)日本呼吸器外科学会, 2020年08月, 日本呼吸器外科学会雑誌, 34(3) (3), O16 - 5, 日本語COPD合併肺癌手術症例において術後の気管支拡張吸入薬の継続により得られる効果
- (株)南江堂, 2019年12月, 胸部外科, 72(13) (13), 1072 - 1075, 日本語
- (一社)日本内視鏡外科学会, 2019年12月, 日本内視鏡外科学会雑誌, 24(7) (7), SF026 - 5, 日本語前縦隔腫瘍に対する剣状突起下アプローチの初期導入成績
- (一社)日本内視鏡外科学会, 2019年12月, 日本内視鏡外科学会雑誌, 24(7) (7), SF048 - 1, 日本語不全分葉例に対するThoracoscopic fissureless lobectomyの有用性
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 682 - 682, 日本語DLL3の発現は、LCNECに対する術後補助化学療法の効果の指標になる
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 697 - 697, 日本語EGFR陽性肺腺癌の切除例における画像所見の臨床的意義
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 713 - 713, 日本語胸腔鏡下上葉切除、下葉切除術後の呼吸機能変化
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 716 - 716, 日本語cN0左上葉肺癌に対する左上区切除の根治性について
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 746 - 746, 日本語第8版TNM分類に基づく肺腺癌pN0症例に対する術後補助化学療法の成績
- (NPO)日本肺癌学会, 2019年11月, 肺癌, 59(6) (6), 964 - 964, 日本語持続陽圧呼吸療法(CPAP)と間質性肺炎、ステロイド療法が誘因と考えられた肺癌術後肺気瘤の1切除例
- (NPO)日本肺癌学会, 2019年04月, 肺癌, 59(2) (2), 199 - 199, 日本語左後縦隔原発傍神経節腫の1切除例
- (一社)日本外科学会, 2019年04月, 日本外科学会定期学術集会抄録集, 119回, SF - 7, 日本語胸腔鏡下肺区域切除後の術後呼吸機能変化
- (一社)日本呼吸器外科学会, 2019年04月, 日本呼吸器外科学会雑誌, 33(3) (3), P59 - 7, 日本語80歳以上の高齢者非小細胞肺癌患者に対する縮小手術の検討
- (一社)日本呼吸器外科学会, 2019年04月, 日本呼吸器外科学会雑誌, 33(3) (3), P60 - 4, 日本語術前HbA1c値が、肺腺癌術後再発に与える影響
- (一社)日本呼吸器外科学会, 2019年04月, 日本呼吸器外科学会雑誌, 33(3) (3), P66 - 1, 日本語肺腺癌切除例における浸潤性粘液性腺癌の臨床的意義
- (一社)日本呼吸器外科学会, 2019年04月, 日本呼吸器外科学会雑誌, 33(3) (3), P105 - 4, 日本語胸腔鏡手術におけるICG蛍光法の使用経験
- 2019年, 日本胸部外科学会定期学術集会(Web), 72nd左上葉における胸腔鏡下肺区域切除術の肺機能温存効果について~胸腔鏡下左上葉切除術との比較
- 2019年, 肺癌(Web), 59(2) (2)左後縦隔原発傍神経節腫の1切除例
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), OS195 - 3, 日本語完全胸腔鏡下に施行したatypical segmentectomyの手術成績
- (一社)日本内視鏡外科学会, 2018年12月, 日本内視鏡外科学会雑誌, 23(7) (7), DP73 - 1, 日本語ICG蛍光を用いた肺癌センチネルリンパ節同定の可能性
- (NPO)日本肺癌学会, 2018年10月, 肺癌, 58(5) (5), 377 - 377, 日本語肺原発横紋筋肉腫の1切除例
- (NPO)日本肺癌学会, 2018年10月, 肺癌, 58(6) (6), 455 - 455, 日本語区域切除後の局所・遠隔転移の実際 再発形式を考慮した積極的区域切除後再発危険因子の解析
- (NPO)日本肺癌学会, 2018年10月, 肺癌, 58(6) (6), 573 - 573, 日本語病理病期I期高悪性度神経内分泌癌の臨床病理学的検討
- (NPO)日本肺癌学会, 2018年10月, 肺癌, 58(6) (6), 591 - 591, 日本語硬化型上皮内腺癌か微少浸潤性腺癌か迷う高分化腺癌の病理組織学的特徴
- (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回, S521 - S522, 日本語肺原発横紋筋肉腫の一例
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), PD2 - 2, 日本語末梢小型肺癌における区域切除後遠隔期の課題 積極的区域切除術後再発の特徴と問題点
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), PD3 - 6, 日本語IV期肺癌における呼吸器外科の役割は拡大しているか? 肺癌加療後の肺内転移に対する外科的治療成績
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), RO3 - 1, 日本語3D-CTによる胸腔鏡下肺区域切除術後の術後残存肺機能の検討
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), P68 - 4, 日本語画像上、肺悪性腫瘍の様相を呈した肺内Castleman病の一手術例
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), P79 - 4, 日本語開胸時胸腔内洗浄細胞診陽性例に対する術後補助化学療法の検討
- (一社)日本呼吸器外科学会, 2018年04月, 日本呼吸器外科学会雑誌, 32(3) (3), P86 - 5, 日本語転移性肺腫瘍切除における最適な術式の検討
- 2018年, 日本胸部外科学会定期学術集会(Web), 71stCT volumetry法を用いた胸腔鏡下肺区域切除術後の残存肺葉機能評価
- 2018年, 日本胸部外科学会定期学術集会(Web), 71st腺扁平上皮癌であることは予後不良因子か?
- 2018年, 肺癌(Web), 58(5) (5)肺原発横紋筋肉腫の1切除例
- (一社)日本外科学会, 2017年04月, 日本外科学会定期学術集会抄録集, 117回, PS - 6, 日本語早期肺腺癌におけるPsf3(GINS3)の発現の意義 組織マイクロアレイを用いたI期症例538例の検討
- 兵庫県外科医会, 2017年, 兵庫県外科医会会誌 = Journal of Hyogo Surgical Association, 51, 3 - 16, 日本語原発性肺癌に対する胸腔鏡下肺葉切除術の有用性に関する研究
- (NPO)日本気管食道科学会, 2016年04月, 日本気管食道科学会会報, 67(2) (2), s31 - s31, 日本語食道癌術後胃管壊死により胃管気管支瘻を来した1例
- (一社)日本外科学会, 2016年04月, 日本外科学会定期学術集会抄録集, 116回, PS - 1, 日本語肺腺癌におけるPsf3(GINS3)の発現の意義 組織マイクロアレイを用いた864例の症例検討
- (一社)日本外科学会, 2016年04月, 日本外科学会定期学術集会抄録集, 116回, OP - 3, 日本語肺癌におけるDNA Helicase蛋白複合体のバイオマーカーおよび分子標的としての有用性の検討
- (一社)日本呼吸器外科学会, 2016年04月, 日本呼吸器外科学会雑誌, 30(3) (3), P73 - 3, 日本語外傷性肺嚢胞に対して緊急手術を要した1例
- (NPO)日本肺癌学会, 2015年08月, 肺癌, 55(4) (4), 317 - 317, 日本語肺癌と鑑別を要した炎症性結節の1例
- 南江堂, 2015年07月, 胸部外科 = The Japanese journal of thoracic surgery, 68(7) (7), 546 - 549, 日本語症例 縦隔成熟奇形腫胸腔内穿破の1例
- (NPO)日本肺癌学会, 2015年02月, 肺癌(Web), 55(1) (1), 78(J‐STAGE) - 78, 日本語肺癌手術材料で腫瘍との鑑別が求められる粘液化生を認めた2例
- (NPO)日本肺癌学会, 2015年02月, 肺癌, 55(1) (1), 78 - 78, 日本語肺癌手術材料で腫瘍との鑑別が求められる粘液化生を認めた2例
- 2015年, 日本呼吸器外科学会総会(Web), 32nd肺切除後の脳梗塞に対し血栓回収療法を行い良好な経過を得た1例
- 2015年, 日本呼吸器外科学会総会(Web), 32nd第2癌を念頭においた第1癌に対する区域切除術の検討
- 2015年, 日本呼吸器外科学会総会(Web), 32nd胸腔鏡手術における血管損傷の危険因子の検討
- 2015年, 日本呼吸器外科学会総会(Web), 32nd抗NMDA受容体脳炎を伴った縦隔奇形腫の1手術例
- 2015年, 日本呼吸器外科学会総会(Web), 32nd肺腺癌におけるCHFR(Checkpoint protein with forkhead and ring finger domain)発現の意義
- 2015年, 日本気胸・嚢胞性肺疾患学会雑誌, 15(1) (1)自然気胸に対するx Gateの使用経験
- 2015年, 日本肺癌学会学術集会号, 56th血管肉腫の肺転移・小腸転移により両側気胸・小腸穿孔をきたした1例
- 2015年, 日本肺癌学会学術集会号, 56th骨軟部悪性腫瘍の肺転移切除例の検討
- 2015年, 日本肺癌学会学術集会号, 56th膜性腎症を契機に発見された肺癌に対し胸腔鏡下肺切除を行った1例
- 2015年, 日本肺癌学会学術集会号, 56thEndo GIA Radial Reloadを用いた胸腔鏡下肺部分切除術の工夫
- 2015年, 日本肺癌学会学術集会号, 56th右肺転移を伴う肺動脈巨大肉腫に対し二期的手術を行い良好な術後経過を得た1例
- 2015年, 日本呼吸器外科学会総会(Web), 32nd酸化セルロースシートの止血効果を利用した胸腔鏡手術の工夫
- 2015年, 肺癌(Web), 55(4) (4)肺癌と鑑別を要した炎症性結節の1例
- 2015年, 肺癌(Web), 55(4) (4)肺炎症性偽腫瘍の1切除例
- 2014年12月, ICUとCCU, 38(12号) (12号), 842 - 843, 日本語ICU・CCU あんな症例、こんな症例(第33回) 肺癌術後早期の脳梗塞に対し血栓回収療法を行い良好な経過を得た症例[査読有り]記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)
- 2014年12月, ONCOLOGY LETTERS, 8(6) (6), 2621 - 2623, 英語[査読有り]記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)
- (NPO)日本肺癌学会, 2014年08月, 肺癌, 54(4) (4), 235 - 235, 日本語神経線維腫症II型に伴った腫瘍破裂の1例
- (NPO)日本肺癌学会, 2014年08月, 肺癌, 54(4) (4), 243 - 243, 日本語腸型が疑われた肺腺癌の1例
- 2014年, 日本外科学会雑誌, 115高齢者非小細胞肺癌に対する外科治療成績
- 2014年, 日本気胸・嚢胞性肺疾患学会雑誌, 14(2) (2)von Willebrand’s Diseaseを基礎疾患にもつ血気胸手術の1例
- 2014年, 日本胸腺研究会プログラム・抄録集, 33rd血胸をきたした胸腺腫破裂の1例
- 2014年, 日本呼吸器外科学会総会(Web), 31stCTでの肺容積測定による術後肺機能評価
- 2014年, 日本気管食道科学会総会ならびに学術講演会プログラム・予稿集, 66th気道狭窄をきたした食道神経鞘腫の1例
- 2014年, 日本呼吸器外科学会総会(Web), 31st高齢者肺葉切除症例のearly outcomeについて
- 2014年, 日本呼吸器外科学会総会(Web), 31st完全鏡視下で肺葉切除後の気管支断端被覆術の工夫
- 2014年, 日本呼吸器外科学会総会(Web), 31st肺癌術後乾性咳嗽に対するトシル酸スプラタストの有用性の検討
- 2014年, 肺癌(Web), 54(2) (2)臍帯血移植前の消失しない肺浸潤影に対して胸腔鏡下肺葉切除を施行した1例
- オプトロニクス社, 2014年01月, Medical Photonics, (16号) (16号), 9 - 14, 日本語肺手術前の高解像度3D-CTによる肺血管同定の有用性[査読有り]記事・総説・解説・論説等(商業誌、新聞、ウェブメディア)
- 一般社団法人日本外科学会, 2013年03月05日, 日本外科学会雑誌, 114(2) (2), 543 - 543, 日本語PS-018-5 肺腺癌におけるPSF3発現の臨床的意義の検討(PS ポスターセッション,第113回日本外科学会定期学術集会)
- 一般社団法人日本外科学会, 2013年03月05日, 日本外科学会雑誌, 114(2) (2), 308 - 308, 日本語WS-9-1 肺腺癌浸潤におけるNecl-5の働きについての検討(WS ワークショップ,第113回日本外科学会定期学術集会)
- 2013年, 日本胸腺研究会プログラム・抄録集, 32ndMetaplastic thymoma切除の1例
- 2013年, 日本呼吸器外科学会総会(Web), 30thPsf3は肺腺癌における予後を判定する新しいバイオマーカーである
- 2013年, 日本外科学会雑誌, 114肺腺癌におけるPSF3発現の臨床的意義の検討
- 2013年, 日本呼吸器外科学会総会(Web), 30th胸腔鏡手術における不測の出血への対応
- 2013年, 日本呼吸器外科学会総会(Web), 30th肺腺癌浸潤におけるNecl-5発現の意義に関する臨床および実験的検討
- 2013年, 日本外科学会雑誌, 114肺腺癌浸潤におけるNecl-5の働きについての検討
- 2013年, 日本外科学会雑誌, 114肺腺癌における予後因子としてのnection-3の発現について
- 2013年, 日本呼吸器外科学会総会(Web), 30thVATS自然気胸手術をより確実なものにするための当科での工夫
- 2013年, 日本肺癌学会学術集会号, 54th高悪性度神経内分泌癌に対する手術症例の臨床的検討
- (NPO)日本肺癌学会, 2012年06月, 肺癌, 52(3) (3), 353 - 354, 日本語肺内転移やリンパ節転移との鑑別が困難であった扁平上皮腺上皮性混合型乳頭腫の1例
- 2012年, 肺癌, 52(5) (5)緊急手術を要した縦隔腫瘍の2例の検討
- 2012年, 日本呼吸器外科学会総会(Web), 29th鏡視下手術の視覚的利点を活かした肺門部からの鈍的剥離による肺区域切除術
- 2012年, 日本呼吸器外科学会総会(Web), 29th心大血管疾患を同時期に合併した原発性肺癌に対する外科治療例の検討
- 2012年, 日本呼吸器外科学会総会(Web), 29th肺腺癌のオーダーメード治療をめざした癌関連遺伝子発現異常の総合的解析
- 2012年, 日本呼吸器外科学会総会(Web), 29th胸壁浸潤非小細胞肺癌切除についての検討
- 2012年, 日本呼吸器外科学会総会(Web), 29th胸腔ドレーン創を離開させないための手技上の工夫
- 2012年, General Thoracic and Cardiovascular Surgery, 60(Supplement) (Supplement)肺区域切除術に対する320列CTに基づいた3DCTシミュレーションの有用性
- 一般社団法人日本外科学会, 2011年05月25日, 日本外科学会雑誌, 112(1) (1), 411 - 411, 日本語SF-061-3 肺腺癌における脱リン酸化酵素Wip1発現の臨床的意義の検討(SF-061 サージカルフォーラム(61)肺:基礎-1,第111回日本外科学会定期学術集会)
- 2011年, 肺癌, 51(5) (5)Pathological stage Iの大細胞神経内分泌癌(LCNEC)に対する術後補助化学療法の検討
- 2011年, 日本呼吸器外科学会雑誌, 25(3(Web)) (3(Web))完全胸腔鏡下手術における分葉不良例での葉間作成法
- 2011年, 日本呼吸器外科学会雑誌, 25(3(Web)) (3(Web))3D-CT血管把握に基づいた胸腔鏡下左S1+2区域切除
- 2011年, 日本気胸・嚢胞性肺疾患学会雑誌, 11(2) (2)HIV関連ニューモシスチス肺炎に併発した気胸に対して手術を施行した1例
- 2011年, 日本呼吸器外科学会雑誌, 25(3(Web)) (3(Web))肺腺癌におけるWip1発現とDNA damageの検討
- 2011年, 肺癌, 51(5) (5)鏡視下手術の視覚的利点を活かした肺区域切除術
- 2011年, 日本呼吸器外科学会雑誌, 25(3(Web)) (3(Web))肺悪性腫瘍手術における完全胸腔鏡下手術と胸腔鏡補助手術の使い分け
- 2011年, 日本呼吸器外科学会雑誌, 25(3(Web)) (3(Web))大細胞神経内分泌癌(LCNEC)に対する補助化学療法とchemo sensitivityに関する検討
- 2011年, General Thoracic and Cardiovascular Surgery, 59(Supplement) (Supplement)肺腺癌におけるγ-H2AX発現の臨床的意義の検討
- 2011年, General Thoracic and Cardiovascular Surgery, 59(Supplement) (Supplement)術前合併症を有する臨床IA期肺癌症例に対するSub-lobar Resectionの意義
- 2010年, 胸部外科, 63(1) (1)Pancoast型肺癌の手術 1.治療成績 肺尖部胸壁浸潤癌に対する外科治療
- 2010年, 日本呼吸器外科学会雑誌, 24(3) (3)肺癌検診と手術成績
- 2010年, 日本呼吸器外科学会雑誌, 24(3) (3)肺癌病期分類第7版改定案に基づいた原発性肺癌手術症例の検討
- 2010年, 肺癌, 50(5) (5)肺癌術後に指摘された肺悪性腫瘍に切除は有用か?
- 2010年, 日本臨床外科学会雑誌, 71腫瘍破裂により突然の胸痛をきたした縦隔奇形腫の1例
- 2010年, 日本呼吸器外科学会雑誌, 24(3) (3)Pathological stage IA非小細胞肺癌におけるCOPD症例の検討
- 2010年, 日本呼吸器外科学会雑誌, 24(3) (3)原発性肺腺癌におけるNecl-5の発現および予後との相関に関する検討
- 2010年, 肺癌, 50(5) (5)血管肉腫肺転移に続発した難治性気胸の1例
- 2010年, 肺癌, 50(1) (1)縦隔発生類上皮血管肉腫の1例
- 一般社団法人日本外科学会, 2009年02月25日, 日本外科学会雑誌, 110(2) (2), 532 - 532, 日本語HP-081-4 肺癌における予後因子の検討(肺(手術1),ハイブリッドポスター,第109回日本外科学会定期学術集会)
- 2009年, 日本呼吸器外科学会雑誌, 23(3) (3)新しい肺癌病期分類の妥当性の検証
- 2009年, 日本呼吸器外科学会雑誌, 23(3) (3)臨床病期IA肺癌に対する消極的縮小切除の検討
- 2009年, 日本呼吸器外科学会雑誌, 23(3) (3)原発性肺癌手術症例に対する術前気管支拡張剤(tiotropiumスピリーバ)投与の有効性に対する検討
- 2009年, 肺癌, 49(3) (3)ウロキナーゼの胸腔内注入が有効であった肺膨張不全の1例
- 2009年, 肺癌, 49(4) (4)胸壁発生myofibloblastic sarcomaの1例
- 2009年, 肺癌, 49(5) (5)CTおよびPET/CTともにc-stage IAと判定された原発性肺癌に対する病理学的検討~縮小手術の適応決定~
- 2009年, 肺癌, 49(5) (5)非小細胞肺癌術後化学療法としてのCBDCA+weekly PTXの第II相多施設共同試験~神戸呼吸器外科グループ~
- 2009年, 肺癌, 49(5) (5)病理病期I期の非小細胞癌における胸膜浸潤の検討
- 2009年, 日本呼吸器外科学会雑誌, 23(3) (3)PET/CTを用いた原発性肺癌における縦隔リンパ節転移の画像評価
- 2009年, 肺癌, 49(4) (4)原発不明縦隔リンパ節癌の2例
- 2009年, 日本呼吸器外科学会雑誌, 23(3) (3)胸腔内原発孤立性線維性腫瘍(Solitary Fibrous Tumor of the pleura;SFTP)外科切除症例についての検討
- 2008年, 日本呼吸器外科学会雑誌, 22(3) (3)肺転移後に未分化転化しG-CSF,GM-CSFを産生した甲状腺癌の1例
- 2008年, 日本呼吸器外科学会雑誌, 22(3) (3)非小細胞肺癌に対するWeekly Paclitaxel+Carboplatin療法に関する検討
- 2008年, 肺癌, 48(5) (5)非小細胞肺癌における胸腔内洗浄細胞診の有用性
- 2008年, 肺癌, 48(5) (5)PET/CTが治療効果判定に有用であった肺癌術後再発の1例
- 2008年, General Thoracic and Cardiovascular Surgery, 56(Supplement) (Supplement)大細胞神経内分泌癌に対する外科治療成績
- 2008年, General Thoracic and Cardiovascular Surgery, 56(Supplement) (Supplement)悪性胸膜中皮腫の外科治療:手術成績と今後の戦略
- 第66回日本気管食道科学会, 2014年11月, 日本語, 日本気管食道科学会, 高知, 国内会議気道狭窄をきたした食道神経鞘腫の1例[招待有り]口頭発表(一般)
- 第73回日本癌学会学術集会, 2014年09月, 日本語, 日本癌学会, 横浜, 国内会議非小細胞肺癌におけるPsf3の役割について[招待有り]口頭発表(一般)
- 第18回日本気胸・嚢胞性肺疾患学会総会, 2014年09月, 日本語, 日本気胸・嚢胞性肺疾患学会, 福岡, 国内会議von Willebrand’s diseaseを基礎疾患にもつ血気胸の1例[招待有り]口頭発表(一般)
- 第18回日本気胸・嚢胞性肺疾患学会総会, 2014年09月, 日本語, 日本気胸・嚢胞性肺疾患学会, 福岡, 国内会議胸腔鏡下自然気胸手術をより確実なものにするためのダブルレイヤー法の検討[招待有り]口頭発表(一般)
- 第100回日本肺癌学会関西支部会, 2014年06月, 日本語, 日本肺癌学会関西支部, 大阪, 国内会議神経線維腫症II型に伴った腫瘍破裂の1例[招待有り]口頭発表(一般)
- 第22回ヨーロッパ胸部外科学会, 2014年06月, 英語, ヨーロッパ胸部外科学会, フランクフルト, ドイツ, 国際会議The significant role of Necl-5 among patients with lung adenocarcinoma[招待有り]口頭発表(一般)
- ATS2014, 2014年05月, 英語, 米国胸部学会, サンフランシスコ, アメリカ, 国際会議Ruptured Thymoma With Homothorax:A Case Report[招待有り]ポスター発表
- 第31回日本呼吸器外科学会総会, 2014年05月, 日本語, 日本呼吸器外科学会, 東京, 国内会議高齢者肺葉切除症例early outcomeについて[招待有り]口頭発表(一般)
- 第31回日本呼吸器外科学会総会, 2014年05月, 日本語, 日本呼吸器外科学会, 東京, 国内会議完全鏡視下で肺葉切除後の気管支断端被覆術の工夫[招待有り]口頭発表(一般)
- 第31回日本呼吸器外科学会総会, 2014年05月, 日本語, 日本呼吸器外科学会, 東京, 国内会議肺癌術後乾性嗽に対するトシル酸スプラタストの有用性の検討[招待有り]口頭発表(一般)
- 第114回日本外科学会総会, 2014年04月, 日本語, 日本外科学会, 京都, 国内会議高齢者非小細胞肺癌に対する外科治療成績[招待有り]口頭発表(一般)
- 第114回日本外科学会総会, 2014年04月, 日本語, 日本外科学会, 京都, 国内会議神経内分泌がんに対する補助化学療法に関する報告[招待有り]口頭発表(一般)
- 第114回日本外科学会総会, 2014年04月, 日本語, 日本外科学会, 京都, 国内会議NOS(not otherwise specified)の臨床的意義[招待有り]口頭発表(一般)
- 第99回日本肺癌学会関西支部会, 2014年02月, 日本語, 日本肺癌学会関西支部, 姫路, 国内会議臍帯血移植前の消失しない肺浸潤影に対して胸腔鏡下肺葉切除を施行した一例[招待有り]口頭発表(一般)
- 第26回日本内視鏡学会, 2013年11月, 日本語, 日本内視鏡学会, 福岡, 国内会議完全鏡視下肺葉切除術における術後合併症、術後補助化学療法の忍容性について-開胸手術との比較[招待有り]口頭発表(一般)
- 第54回日本肺癌学会総会, 2013年11月, 日本語, 日本肺癌学会, 東京, 国内会議高齢者非小細胞肺癌に対する外科治療成績[招待有り]口頭発表(一般)
- 第54回日本肺癌学会総会, 2013年11月, 日本語, 日本肺癌学会, 東京, 国内会議高悪性度神経内分泌癌に対する手術症例の臨床的検討[招待有り]口頭発表(一般)
- 第26回日本内視鏡学会, 2013年11月, 日本語, 日本内視鏡学会, 福岡, 国内会議胸腔鏡下肺部分切除術のこだわりと工夫-Endo GIA Radial Reload[招待有り]口頭発表(一般)
- 第66回日本胸部外科定期学術集会, 2013年10月, 日本語, 日本胸部外科学会, 仙台, 国内会議転移性肺腫瘍に対する胸腔鏡手術の有用性の検討[招待有り]口頭発表(一般)
- 第66回日本胸部外科定期学術集会, 2013年10月, 日本語, 日本胸部外科学会, 仙台, 国内会議非小細胞肺癌切除例におけるNOS(not specific otherwise)の臨床的意義について[招待有り]口頭発表(一般)
- ECCO_ESMO_ESTRO2013, 2013年09月, 英語, ESMO, ブリュッセル, オランダ, 国際会議Pleural lavage cytology is a significant prognostic factor for stage I lung adenocarcinoma patients[招待有り]ポスター発表
- ESTS 2013, 2013年06月, 英語, ESTS, バーミンガム, イギリス, 国際会議The efficacy of 320-detector row computed tomography for the assessment of preoperative pulmonary vasculature of candidates for pulmonary segmentectomy[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議胸腔鏡手術における不測の出血への対応[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議肺腺癌浸潤におけるNecl-5発現の意義に関する臨床および実験的検討[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議The role of Necl-5 in the invasive activity of lung adenocarcinoma[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議Psf3は肺腺癌における予後を判定する新しいバイオマーカーである[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議VATS自然気胸手術をより確実なものにするための当科での工夫[招待有り]口頭発表(一般)
- 第30回日本呼吸器外科学会総会, 2013年05月, 日本語, 日本呼吸器外科学会, 名古屋, 国内会議厳選ビデオ 胸腔鏡手術における不測の出血時の対応[招待有り]口頭発表(一般)
- 第113回日本外科学会, 2013年04月, 日本語, 日本外科学会, 福岡, 国内会議がん細胞の浸潤転移機構の解明と治療への展開 肺腺癌浸潤におけるNecl-5の働きについての検討[招待有り]口頭発表(一般)
- 第113回日本外科学会, 2013年04月, 日本語, 日本外科学会, 福岡, 国内会議肺腺癌におけるPSF3発現の臨床的意義の検討[招待有り]口頭発表(一般)
- 第113回日本外科学会, 2013年04月, 日本語, 日本外科学会, 福岡, 国内会議肺腺癌における予後因子としてのNectin-3の発現について[招待有り]口頭発表(一般)
- 第113回日本外科学会, 2013年04月, 日本語, 日本外科学会, 福岡, 国内会議肺腺癌浸潤におけるNecl-5の働きについての検討[招待有り]口頭発表(一般)
- 第53回日本肺癌学会総会, 2012年11月, 日本語, 日本肺癌学会, 岡山, 国内会議ALK染色陽性肺腺癌の術前診断の可能性[招待有り]ポスター発表
- 日本学術振興会, 科学研究費助成事業, 若手研究(B), 神戸大学, 2014年04月01日 - 2016年03月31日Ex vivo lung perfusionを用いた新しい臓器保存法の確立肺移植における臓器保存は冷保存が一般的であるが、近年Ex vivo lung perfusion(EVLP)が臨床応用されている。我々は、これまでEVLPで重要視されていなかった気管支動脈にも還流液を流すシステム(Dual EVLPシステム)を考案し、その効果を検証した。その結果、①Airway Hypoxia の克服、②肺組織のmetabolism の改善により我々の方法が従来よりも良好な臓器保存法になる可能性が示唆された。
