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林 申也大学院医学研究科 医科学専攻講師
研究活動情報
■ 受賞- 2019年03月 日本軟骨代謝学会, 日本軟骨代謝学会賞, サイクリンディペンデントキナーゼインヒビター1欠損マウスは炎症の 増悪を伴い変形性関節症が進行する
- 2015年11月 日本バイオマテリアル学会, Journal of Materials chemistry B賞, エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する国内学会・会議・シンポジウム等の賞
- Cancer stem cells (CSCs) have been implicated as critical mediators in the progression, chemoresistance and metastatic capabilities of diverse malignancies, including osteosarcoma (OS). The authors have succeeded in generating CSC‑like cells (MG‑OKS) from the OS cell line MG‑63 by transducing defined factors. A significant increase in small proline‑rich protein 1A (SPRR1A) expression, a cross‑linked envelope protein in keratinocytes, was observed in MG‑OKS cells. Therefore, SPRR1A could be involved in tumor initiation, growth and poor OS progression. However, its specific role in OS remains unclear. The present study aimed to evaluate the role of SPRR1A in OS both in vitro and in vivo using MG‑OKS cells. Three experimental groups were established: MG‑OKS cells transfected with SPRR1A small interfering (si)RNA (siMG‑OKS), untransfected MG‑OKS cells and MG‑OKS cells transfected with scrambled siRNA (scMG‑OKS) as controls. SPRR1A expression, morphological changes, cell proliferation and migration were assessed in these groups. RNA sequencing was performed to examine the genetic changes caused by SPRR1A suppression. To evaluate tumorigenicity in vivo, cells from each group were subcutaneously transplanted into the backs of nude mice. Tumor volume and Ki‑67 expression were assessed and compared among the three groups at four weeks post‑transplantation. The siMG‑OKS group exhibited altered cell morphology, reduced cell proliferation and decreased migratory abilities in vitro. RNA sequencing revealed suppression of genes involved in cell adhesion in the siMG‑OKS group. Furthermore, the in vivo tumorigenicity of siMG‑OKS was lower than that of the other two experimental groups. These findings suggest that SPRR1A is one of the key cell adhesion‑related molecules involved in OS progression, potentially serving as a therapeutic target for this refractory tumor. However, further research is needed to fully elucidate the mechanisms by which SPRR1A influences OS pathogenesis and to explore its clinical potential.2025年02月, Oncology reports, 53(2) (2), 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: This study aimed to evaluate differences in the pattern of fixation with a rectangular tapered short stem (Fitmore stem) due to proximal femoral medullary cavity morphology based on periprosthetic bone mineral density (BMD) and radiological findings. MATERIALS AND METHODS: We analyzed 105 consecutive patients (Dorr type A, 18; Dorr type B, 66; Dorr type C, 21) who underwent total hip arthroplasty using a Fitmore stem. Periprosthetic BMD was measured using dual-energy X-ray absorptiometry from 1 to 24 months postoperatively and radiological analysis was performed. Clinical outcomes were evaluated using the Harris hip score (HHS) and the University of California Los Angeles (UCLA) activity score preoperatively and 24 months postoperatively. RESULTS: At 24 months postoperatively, Dorr type C had significantly decreased BMD changes in Gruen zones 2, 6, and 7 compared to Dorr types A and B, and conversely, significantly increased BMD changes in zone 4 (p < 0.05). Dorr type C had significantly greater subsidence than the other types (p < 0.01) and significantly higher cortical hypertrophy in zone 3 (p < 0.01). Stress shielding was not significantly different between Dorr types. The preoperative and postoperative HHS and UCLA activity scores showed no significant differences between the Dorr types. CONCLUSIONS: In Dorr type C, BMD significantly decreased in the proximal femur with a rectangular tapered short stem, suggesting that the stem was fixed at the distal part. Careful observation of this prosthesis over time is needed in patients with Dorr type C.2024年08月, Archives of orthopaedic and trauma surgery, 144(8) (8), 3857 - 3864, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Bone maintenance after total hip arthroplasty (THA) is important for implant success. This study aimed to investigate the relationship between patient characteristics and periprosthetic bone maintenance after THA for better implant selection. MATERIALS AND METHODS: This retrospective cohort study enrolled 112 consecutive patients who underwent THA using full hydroxyapatite (HA) compaction with short (n = 55) or short-tapered wedge (n = 61) stems. Periprosthetic bone mineral density (BMD) was compared between the two groups after propensity score matching, and the relationship between periprosthetic BMD changes and patient background was analyzed. RESULTS: Both groups showed similar periprosthetic BMD changes after adjusting for patient background using propensity score matching. Canal flare index > 3.7 in patients that underwent THA using tapered-wedge stem (odds ratio (OR), 3.2; 95% confidence interval (CI), 1.3-7.9, p = 0.013) and baseline zone 1 BMD > 0.65 in patients that received with short HA compaction stems (OR, 430.0; 95% CI 1.3-1420, p = 0.040) were associated with proximal periprosthetic bone maintenance after THA. CONCLUSION: Considering their predictive value, canal flare index and zone 1 BMD assessment might be useful strategies for implant selection during THA.2024年05月, Archives of orthopaedic and trauma surgery, 英語, 国際誌研究論文（学術雑誌）
- The alignment philosophy in total knee arthroplasty (TKA) has tended to shift from the gold standard of mechanically aligned technique to personalized alignment, such as the kinematically aligned (KA) technique. However, the influences of different surgical techniques on lower limb alignment relative to the ground are not fully investigated. This study investigated the influence of the ankle and hindlimb alignment change after mechanically aligned TKA and KA-TKA. The varus osteoarthritic patients who underwent TKAs were divided into a mechanically aligned TKA group (group M, n = 50) and a KA-TKA group (group K, n = 50). Radiographic parameters (hip-knee-calcaneus [HKC] angle, hip-knee-ankle [HKA] angle, talar tilt angle [TTA], and tibiocalcaneal angle [TCA]) were investigated using full-length standing radiographs. The deviation angle (ΔTA; angle between the tibial mechanical axis [TMA] and the ground tibial mechanical axis [gTMA]) and the change of ΔTA (cΔTA) were also assessed. These parameters were compared between the two groups, along with the correlation between the preoperative HKA angle and other parameters. ΔTA, TTA, and TCA showed no differences between the groups pre- and postoperatively, and no significant changes were observed postoperatively. The preoperative HKA angle showed a significant negative correlation with cΔTA in both groups (group M: r = -0.33, p = 0.02; group K: r = -0.29, p = 0.04) although no correlation was observed the with preoperative TTA and TCA. Despite no change in ΔTA after surgery, the preoperative varus deformity was associated with a change in the deviation between gTMA and TMA after surgery. A severely varus knee may be inappropriate for ground KA-TKA.2024年05月, The journal of knee surgery, 37(6) (6), 409 - 415, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The indication for unicompartmental knee arthroplasty (UKA) has been extended to cases with some degree of preoperative knee flexion contracture recently. The purpose of this study was to clarify the effect of flexion contracture on component angles. MATERIALS AND METHODS: Thirty-five fixed-bearing UKAs using the spacer block technique with preoperative flexion contracture (Group FC) and 35 UKAs using the same technique without preoperative flexion contracture (Group NC) were included. Using radiographs, the coronal femoral component angle, coronal tibial component angle, sagittal femoral component angle, and sagittal tibial component angle were determined. Also, extension and flexion angles of the knee as well as coronal Hip-Knee-Ankle (HKA) angles in long-leg standing radiographs were measured. The data about the thickness of the selected insert were also collected. The above results were compared between the two groups. RESULTS: The femoral component tended to be placed in a more varus and flexed position in Group FC, while no significant difference was found about the tibial component angles. While there was no significant difference in pre- and postoperative knee flexion angles between the two groups, flexion contracture remained postoperatively in Group FC. Preoperative HKA angle was greater in Group FC while the difference was no longer significant postoperatively. Regarding the thickness of the selected insert, thicker inserts tended to be used in Group FC. CONCLUSIONS: In fixed-bearing UKA with the spacer block technique, the femoral component tended to be placed in a flexed and varus position in the knees with preoperative flexion contracture.2024年05月, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 34(4) (4), 2185 - 2191, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Correct cup placement in total hip arthroplasty (THA) for patients with developmental dysplasia of the hip (DDH) is considerably difficult. This study aimed to analyze the orientation accuracy of cup insertion during THA using a portable navigation system in patients with DDH. MATERIALS AND METHODS: In this retrospective cohort study, we analyzed data from 64 patients who underwent THA using infrared stereo camera-matching portable navigation. Patients underwent THA via the anterolateral approach in the lateral decubitus position. Navigation records for intraoperative cup angles, postoperative cup angles measured on computed tomography (CT) images, and cup angle measurement differences were measured and compared between patients with non-DDH/mild DDH and severe DDH. Furthermore, the predictive factors for outliers of accurate acetabular cup placement were analyzed. RESULTS: The average measurement absolute abduction differences (postoperative CT-navigation record) were 3.9 ± 3.5° (severe DDH) and 3.3 ± 2.6° (non-DDH/ mild DDH), and the anteversion differences were 4.7 ± 3.4° (severe DDH) and 2.3 ± 2.1° (non-DDH/ mild DDH). The anteversion difference was different between the two groups. Multivariate analysis showed that the navigation difference (absolute difference in anteversion between postoperative CT and navigation records of > 5°) was significantly associated with severe DDH (odds ratio [OR]: 3.3; p = 0.049, 95% confidence interval [CI]: 1.0-11.1) and posterior pelvic tilt (OR: 1.1; p = 0.042, 95% CI: 1.0-1.27). CONCLUSIONS: In patients with severe DDH, it is important to pay close attention during THA using portable navigation. However, the average difference was < 5º even in patients with severe DDH, and the accuracy may be acceptable in a clinical setting when the cost is considered.2024年05月, Archives of orthopaedic and trauma surgery, 144(5) (5), 2429 - 2435, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Only a few reports have been published so far on factors that predict postoperative coronal alignment after unicompartmental knee arthroplasty (UKA). The purpose of this study is to clarify the relationship between the arithmetic hip-knee-ankle angle (aHKA) and postoperative coronal alignment after medial fixed-bearing UKA. METHODS: One hundred and one consecutive patients (125 knees) who underwent medial fixed-bearing UKA were assessed. Pre- and postoperative coronal HKA angles, lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), and the thickness of the tibial and femoral bone cut were measured. aHKA was calculated as 180° - LDFA + MPTA. Correlations between postoperative HKA angle and aHKA, LDFA, and MPTA were investigated by single regression analysis. After the patients were divided into three groups according to the postoperative HKA angle, i.e., HKA angle > 180°, 175° < HKA angle ≤ 180°, and HKA angle ≤ 175°, aHKA, LDFA, MPTA, preoperative HKA angle, and the thickness of the distal femoral as well as tibial bone cut were compared among the three groups. RESULTS: aHKA and MPTA were positively correlated with postoperative HKA angle, while no correlation was found between postoperative HKA angle and LDFA. Among the three groups classified by postoperative HKA angle, significant differences were found in aHKA, MPTA, and preoperative HKA angle, while no significant difference was found in LDFA and the amount of distal femoral and tibial osteotomies. CONCLUSIONS: aHKA was correlated with postoperative HKA angle after medial fixed-bearing UKA, which was probably due to the influence of MPTA.2024年04月, International orthopaedics, 48(4) (4), 889 - 897, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Total knee arthroplasty (TKA) for Charcot arthropathy of the knee is considered controversial because of its higher complication rate compared with that of TKA for osteoarthritis. In this study, we investigated the clinical outcomes, survival rates, and complications of primary TKA for Charcot arthropathy. METHODS: We conducted a retrospective analysis of nine patients (12 knees) with Charcot arthropathy who underwent TKA. The mean age of the patients was 63.9 ± 9.4 years (range, 52-83 years). The most frequent causative disease was diabetes mellitus (three patients). Patients' clinical outcomes, including the 2011 Knee Society Score and the range of motion, were compared between preoperative and the most recent postoperative data. The 5- and 10-year survival rates for aseptic revision, revision due to infection, and complications were examined. The mean follow-up period was 7.3 ± 3.9 years (range, 3-14 years). RESULTS: The 2011 Knee Society Score and the knee flexion angle significantly improved after TKA surgery (P < 0.05). The 5-year survival rates for aseptic revision, revision due to infection, and complications were 100%, 91.7%, and 83.3%, respectively; the 10-year survival rates for these parameters were the same. One patient underwent revision for insert replacement due to periprosthetic infection, and the other patient had varus/valgus instability due to soft tissue loosening. CONCLUSIONS: The mid- to long-term results of TKA for Charcot arthropathy were generally favorable. Our findings indicate that TKA may be a viable treatment option for Charcot arthropathy.2024年03月, Indian journal of orthopaedics, 58(3) (3), 308 - 315, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Synovial hyperplasia caused by rheumatoid arthritis (RA), an autoimmune inflammatory disease, leads to the destruction of the articular cartilage and bone. A member of the tumor necrosis factor superfamily, Lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) has been shown to correlate with the pathogenesis of RA. METHODS: We used cDNA microarray analysis to compare the expression of genes in rheumatoid fibroblast-like synoviocytes with and without LIGHT stimulation. RESULTS: Significant changes in gene expression (P-values < 0.05 and fold change ≥ 2.0) were associated mainly with biological function categories of glycoprotein, glycosylation site as N-linked, plasma membrane part, integral to plasma membrane, intrinsic to plasma membrane, signal, plasma membrane, signal peptide, alternative splicing, and topological domain as extracellular. CONCLUSIONS: Our results indicate that LIGHT may regulate the expression in RA-FLS of genes which are important in the differentiation of several cell types and in cellular functions.2024年02月, Molecular biology reports, 51(1) (1), 356 - 356, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The relationship between the severity of preoperative varus deformity and the amount of its correction in unicompartmental knee arthroplasty (UKA) as well as the thickness of the insert has not been well known. METHODS: One hundred and three patients who underwent medial fixed-bearing UKA with the use of the spacer block method were assessed. After the component gap in extension was measured using a UKA tensor, the pre-osteotomy gap was calculated from the thickness of the bone cuts. The relationship between the preoperative hip-knee-ankle (HKA) angle as well as the pre-osteotomy gap and the amount of change in HKA angle were analysed. Also, preoperative HKA angle and the thickness of the bone cuts were compared among groups by the insert thickness. RESULTS: The mean preoperative HKA angle was 7.7 ± 3.1° varus. Patients with more varus deformity and those with a wider pre-osteotomy gap showed a more valgus change in HKA angle. As for the thickness of the insert, the preoperative HKA angle of the patients with the thinnest insert was significantly smaller (less varus) than that of those with the thicker insert while no statistically significant difference was found among the insert groups regarding the amount of the bone cuts. CONCLUSIONS: The severity of the preoperative varus deformity as well as the intraoperative pre-osteotomy gap related to the amount of change in HKA angle. As thick inserts tended to be used in severe varus knees, the tibial bone cut can be reduced in such cases.2024年01月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29(1) (1), 183 - 187, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVE: Krüppel-like zinc finger transcription factors (KLFs) play diverse roles in mammalian cell differentiation and development. In this study, we investigated the function of KLF15 in the progression of osteoarthritis (OA). METHODS: 0Destabilization of the medial meniscus (DMM) surgery was performed in 10-week-old male wild-type control (WT) mice and cartilage-specific KLF15 knockout (KO) mice. Histological analysis, immunohistochemistry, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining were performed. Morphological changes were measured using microcomputed tomography. Six mice from each group were analyzed (total number of mice analyzed: 60). In vitro, immunofluorescence, quantitative reverse transcription-polymerase chain reaction, and western blot analyses were performed. RESULTS: KLF15 KO DMM mice exhibited significant cartilage degradation compared to WT mice. According to the Osteoarthritis Research Society International cartilage OA-histopathology scoring system, the mean sum score in KLF15 KO mice was significantly higher than that in WT mice at 8 weeks after surgery. Immunohistochemistry results revealed KLF15 KO mice exhibited reduced peroxisome proliferator-activated receptor gamma (PPARγ) expression, increased pIKKα/β, a disintegrin-like and metalloproteinase with thrombospondin motifs (ADAMTS) 5, and Matrix metalloproteinases (MMP13) expression, and reduced Forkhead box O (FOXO1) and Light chain 3B (LC3B) expression. Inhibition of PPARγ phosphorylation accelerated the effects of interleukin (IL) 1β-treatment in both KLF15 KO and WT chondrocytes, and activation of PPARγ expression canceled the IL1β-induced catabolic effects. CONCLUSION: Our results indicated that the OA phenotype of KLF15 KO DMM mice was influenced by reduced PPARγ expression, including enhanced pIKKα/β, ADAMTS5, and MMP13 expression, reduced autophagy, and increased apoptosis. KLF15 regulation may constitute a possible therapeutic strategy for the treating OA.2024年01月, Osteoarthritis and cartilage, 32(1) (1), 28 - 40, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Currently, studies on adipose-derived stromal vascular fraction (SVF) cells are attracting increasing attention because they have the potential to differentiate into a subset of cell types, such as bone marrow-derived mesenchymal stromal cells (MSCs), and are easier to harvest than MSCs, thus making them easier to apply clinically. This study evaluated the short-term clinical outcomes of SVF cell therapy for hip osteoarthritis (OA). METHODS: Forty-two patients were enrolled in this study; these patients received a single injection comprising an average of 3.8 (standard deviation [SD], ±1.3) × 107 SVF cells into the hip joint. All patients were followed-up for at least 6 months. The mean age of the patients was 60.2 years (SD, ±9.4 years). Kellgren-Lawrence (KL) grades II, III, and IV based on radiography were 13, 13, and 16 patients, respectively. SVF cells were obtained from the subcutaneous fat of the abdomen or breech using a Celution® 800/CRS system. The average cell viability of SVF cells was 90.8% (SD, ±2.8%). Clinical assessments were performed using the Harris Hip Score (HHS), Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) score, and visual analog scale (VAS) score to evaluate pain. Images were evaluated using radiography, and T2 mapping values were obtained using a 1.5-T magnetic resonance imaging system. These clinical and imaging assessments were followed from preoperatively to 6 months postoperatively. RESULTS: The HHS, JHEQ score, and VAS score improved significantly from 22.5 (SD, ±16.6), 26.6 (SD, ±11.3), and 75.5 (SD, ±15.8) preoperatively to 46.8 (SD, ±27.2), 39.4 (SD, ±19.7), and 46.5 (SD, ±27.9), respectively, at 6 months postoperatively. KL grade II showed significant improvement in clinical outcome from preoperative to postoperative, while KL grade IV showed slight or little improvement. The center edge angle, acetabular head index on the radiographs, and T2 mapping values did not change significantly from preoperatively to 6 months postoperatively. CONCLUSIONS: SVF cell injection in the hip joint showed good short-term clinical efficacy for reducing hip OA symptoms. SVF cell therapy is thus an innovative and effective treatment for hip OA.2023年12月, Regenerative therapy, 24, 94 - 102, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: The aim of this study is to compare the accuracy of acetabular cup positioning between the accelerometer-based navigation system and the augmented reality-based navigation system during THA in the supine position. MATERIALS AND METHODS: This retrospective study included 66 patients (70 hips) who underwent THA using two types of portable navigation system, Hip Align or AR-Hip, in the spine position. The absolute difference between the intraoperative navigation record and postoperative measurement using computed tomography data was evaluated. Preoperative clinical factors that decreased the accuracy of cup positioning by ≥ 3° were analyzed via multiple logistic regression analyses. RESULTS: The average absolute error of inclination was 2.8 ± 2.6° in Hip Align and 2.7 ± 1.8° in AR-Hip, and absolute anteversion error was 2.5 ± 2.0° in Hip Align and 2.6 ± 2.2° in AR-Hip, and there was no significantly different between the two navigation systems. There was a significant association between the absolute measurement error (≥ 3°) of cup inclination and patients' BMI in the Hip Align group [odds ratio (OR) 1.350; 95% confidence interval (CI) 1.035-1.760; p = 0.027], but not in the AR-Hip group. CONCLUSIONS: The accuracy of the acetabular cup positioning between the Hip Align and AR-Hip showed no difference during THA in the spine position. The high BMI could have negative influence on the accuracy of cup positioning in THA using Hip Align, thus AR-Hip could be designable for obesity patients.2023年12月, Archives of orthopaedic and trauma surgery, 143(12) (12), 7229 - 7235, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND Distal femoral and proximal tibial fractures often lead to nonunion and post-traumatic osteoarthritis, and total knee arthroplasty (TKA) has emerged as an effective alternative for older patients. This report includes 3 cases of successful TKA treatment. The cases involve a 42-year-old man and a 62-year-old man with Hoffa coronal fractures of the distal femur, and a 50-year-old man with a proximal tibial fracture. These patients underwent multiple osteosynthesis procedures before receiving TKA. CASE REPORT Case 1: A 42-year-old man with a displaced Hoffa's fracture had persistent knee pain. Nonunion post-initial fixation led to reoperation with iliac bone grafting and plate fixation. TKA using a Posterior Stabilized (PS)-type implant resulted in improved motion and function after 3 years. Case 2: A 62-year-old man suffered lateral condyle and ligament injuries from a displaced Hoffa's fracture. Despite plate fixation, dislocation occurred, requiring conversion. TKA with long-stem hinge-type implant, using augmentation block, led to enhanced stability and outcomes at 2 years. Case 3: A 50-year-old man's tibial nonunion, treated with plate fixation, resulted in infection and bone fusion. TKA using a constrained PS-type implant insert addressed the lateral tibial adhesions via iliotibial band (ITB) release and treated severe tibial plateau damage. Positive results were seen at 1 year. CONCLUSIONS The challenges of pseudarthrosis, like bone defects and compromised tissue, highlight the need for precise implant selection based on evaluations of bone quality, defects, knee stability, and hyperextension, rather than resorting to overly-constrained implants.2023年11月, The American journal of case reports, 24, e941187, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The load-bearing pattern of periprosthetic bone may differ between patients who underwent simultaneous bilateral and unilateral total hip arthroplasty (THA). We investigated the differences in periprosthetic bone remodeling after simultaneous bilateral total hip arthroplasty and unilateral total hip arthroplasty. METHODS: This retrospective cohort study enrolled 154 consecutive patients undergoing THA using full hydroxyapatite (HA) compaction short stems. Patient characteristics including age, body mass index, University of California Los Angeles (UCLA) activity score, and bone shape of the proximal femur were adjusted by propensity score matching. Subsequently, periprosthetic bone mineral density changes were compared between simultaneous bilateral and unilateral THA. RESULTS: We found that bone mineral density loss in the simultaneous bilateral THA group was significantly higher in zones 6 and 7 at 24 months after THA (zone 6, p = 0.019; zone 7, p = 0.041). Periprosthetic bone mineral density loss was not associated with clinical factors, including age, body mass index, and daily activity. Additionally, we demonstrated that periprosthetic bone mineral density loss was higher in zones 1, 4, 6, and 7 of patients with a normal hip on the contralateral side after unilateral THA (zone 1, p = 0.041; zone 4, p = 0.041; zone 6, p = 0.037; zone7, p = 0.019). CONCLUSIONS: The postoperative periprosthetic bone remodeling was lower in patients who underwent simultaneous bilateral THA than in those who underwent unilateral THA, even though patient characteristics were adjusted by propensity matching. Further observation of periprosthetic bone mineral density loss is needed to clarify the differences between the groups.2023年11月, International orthopaedics, 47(11) (11), 2767 - 2772, 英語, 国際誌研究論文（学術雑誌）
- Charcot arthropathy is a rapidly progressive and destructive form of arthropathy caused by various neurological diseases. Total hip arthroplasty (THA) is usually contraindicated in patients with Charcot arthropathy; however, recent studies have reported good results following THA in this patient population. Herein, we report a case of Charcot arthropathy secondary to syphilis in a patient who was successfully treated with constrained THA, a new type of THA. A 56-year-old man was injured in a car accident, and a displaced acetabular fracture was revealed three weeks later. He was treated conservatively but soon developed greater displacement of the fracture and femoral head destruction. The patient was referred to our hospital for further treatment. The patient had pelvic pseudarthrosis secondary to Charcot arthropathy at the time of the first visit to our hospital. First, THA was performed with the acetabular reconstruction of the deficient bone. However, the acetabular implant was displaced one week postoperatively. THA revision was performed using a constrained cup. Postoperatively, the patient exhibited good hip stability without dislocation. However, displacement of the acetabular cup occurred one year after the second surgery. We performed a re-revision of THA using a new type of constrained cup that offers a high level of constraint to maintain range of motion (ROM) and prevent dislocations. The patient was able to walk with a T-cane one year postoperatively. Herein, we report a difficult case of revision THA in a patient with Charcot arthropathy concomitant with syphilis. THA is usually contraindicated in patients with Charcot arthropathy; however, we propose that THA using constrained cups that offer a wider ROM may be a useful therapeutic strategy for the treatment of Charcot arthropathy.2023年11月, Cureus, 15(11) (11), e48295, 英語, 国際誌
- The stromal-vascular fraction (SVF), comprising heterogeneous cell populations and adipose-derived stromal cells (ADSCs), has therapeutic potential against osteoarthritis (OA); however, the underlying mechanism remains elusive. This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit SVF on rabbit chondrocytes. Rabbit SVF and ADSCs were autografted into knees at OA onset. The SVF (1 × 105) and low-dose ADSCs (lADSC; 1 × 104) groups adjusted for their stromal cell content were compared. Animals were euthanized 8 and 12 weeks after OA onset for macroscopic and histological analyses of OA progression and synovitis. Immunohistochemical and real-time polymerase chain reaction assessments were conducted. In vitro, immune-fluorescent double staining was performed for SVF to stain macrophages with F4/80, CD86(M1), and CD163(M2). OA progression was markedly suppressed, and synovitis was reduced in the SVF groups (OARSI histological score 8 W: 6.8 ± 0.75 vs. 3.8 ± 0.75, p = 0.001; 12 W: 8.8 ± 0.4 vs. 5.4 ± 0.49, p = 0.0002). The SVF groups had higher expression of collagen II and SOX9 in cartilage and TGF-β and IL-10 in the synovium, lower expression of MMP-13, and lower macrophage M1/M2 ratio than the lADSC groups. Immunofluorescent double staining revealed a markedly higher number of M2 than that of M1 macrophages in the SVF. The therapeutic effects of SVF on chondrocytes were superior than those of lADSCs, with enhanced anabolic and inhibited catabolic factors. Heterogeneous cells, mainly M2 macrophages in the SVF, enhanced growth factor secretion and chondrocyte-protective cytokines, thus benefiting chondrocytes and knee joint homeostasis. Overall, the SVF is a safe, relatively simple, and a useful treatment option for OA.2023年10月, Stem cell reviews and reports, 19(7) (7), 2407 - 2419, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Assessment of the conventional mechanical axis (MA) (hip-to-talus axis) is reported to result in constitutional varus in the native knee. However, the ground MA (hip-to-calcaneus axis), which is the line from the hip center to the bottom of the calcaneus, passes through the center of the knee joint in the native knee and is a possible alternative target for total knee arthroplasty (TKA) assessments. Therefore, this study aimed to present a "ground kinematically aligned (KA)-TKA." In this technique, the femoral component is placed on the cylindrical axis using the calipered technique and the tibial component is placed to give a neutral ground MA. Radiographical investigation was used to determine whether physiological alignment can be individually achieved with ground KA-TKA; this was compared with that of a tibia-restricted modified KA-TKA, referring to conventional MA (hip-to-talus axis) results. METHODS: As the primary endpoint, this prospective cohort study compared the ground MA ratios of the knee joints in 40 ground KA-TKAs (G group: Coronal Plain Alignment of the Knee (CPAK) 28 type I, 7 II, 1 IV, and 4 V) with those of the preceding 60 modified KA-TKAs (M group: CPAK 46 type I, 12 II, and 2 V) performed for patients with varus osteoarthritis (OA). The number of outliers differing over ± 5% from the neutral were compared between groups using the χ2-test. The Hip-knee-ankle (HKA) angle, coronal femoral/tibial component alignment (FCA/TCA), and joint line orientation angle (JLOA) were compared between the groups using non-paired t-tests. Statistical significance was set at p < 0.05. RESULTS: The G group had a higher ratio of the ground MA passing through the knee center than the M group did; outliers differing over ± 5% from the neutral of the ground MA were 2/40 cases in the G group and 20/60 cases in the M group, which was a significant difference (p = 0.001). The HKA angle, FCA/TCA, and JLOA were not significantly different between the groups. CONCLUSIONS: Targeting the ground MA in KA-TKA for patients with varus OA was feasible and has the potential to provide a physiological alignment more similar to the native knee in TKA than other kinematic alignment techniques. LEVEL OF EVIDENCE: Level III.2023年09月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(9) (9), 3880 - 3888, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to evaluate kinematically aligned total knee arthroplasty (KA-TKA) targeting the neutral ground mechanical axis (MA) (hip-to-calcaneus axis), the line from the hip centre to the bottom of the calcaneus, (ground KA-TKA) in terms of its comparison with tibia-restricted modified KA-TKA (modified KA-TKA). METHODS: This retrospective cohort study included 106 consecutive patients who underwent unilateral KA-TKA for varus osteoarthritis (OA) (60 modified KA-TKAs and 46 ground KA-TKAs). After 1:1 propensity score matching, 60 patients (30 pairs) were matched between the groups with comparable demographic data. The hip-knee-ankle (HKA) angle, coronal femoral component alignment (FCA), and coronal tibial component alignment (TCA) were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance, was also compared between the groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score, were compared between groups. RESULTS: The HKA angle and FCA/TCA were not significantly different between groups. Whereas the varus/valgus balance showed no significant differences between groups, smaller joint component gaps were found throughout the range of motion in the ground KA-TKA group than in the modified KA-TKA group. Despite no difference in clinical scores between groups, a significantly deeper postoperative flexion angle was achieved in the ground KA-TKA group than in the modified KA-TKA group (p < 0.05). CONCLUSION: Targeting neutral ground MA in KA-TKA for patients with varus OA has the potential to provide a better flexion angle with stable intraoperative soft tissue balance.2023年09月, International orthopaedics, 47(9) (9), 2215 - 2223, 英語, 国際誌研究論文（学術雑誌）
- The number of advanced-age patients with spinal metastases is rising. This study was performed to clarify the characteristics and surgical outcomes of spinal metastases in advanced-age patients. We prospectively analyzed 216 patients with spinal metastases from 2015 to 2020 and divided them into three age groups: <70 years (n = 119), 70-79 years (n = 73), and ≥80 years (n = 24). Although there were no significant intergroup differences in preoperative characteristics and surgery-related factors except for age, patients aged ≥80 years tended to have a worse performance status (PS), Barthel index, and EuroQol-5 dimension (EQ-5D) before and after surgery than the other two groups. Although the median PS, mean Barthel index and mean EQ-5D greatly improved postoperatively in each group, the median PS and mean Barthel index at 6 months and the mean EQ-5D at 1 month postoperatively were significantly poorer in the ≥80-year group than the 70-79-year group. The rates of postoperative complications and re-deterioration of the EQ-5D were significantly higher in the oldest group than in the other two groups. Although surgery for spinal metastases improved the PS, Barthel index, and EQ-5D regardless of age, clinicians should be aware of the poorer outcomes and higher complication rates in advanced-age patients.2023年07月, Journal of clinical medicine, 12(14) (14), 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to examine the prosthetic orientations, limb alignment, intraoperative soft tissue balance, and early clinical outcomes associated with the use of the relatively new handheld robot technique compared to those associated with the use of the conventional alignment guide for bi-cruciate stabilized total knee arthroplasty (TKA). METHODS: This retrospective cohort study compared the prosthetic orientation and limb alignment of 35 patients who underwent TKA using robotic assistance (robot group) with those of patients who underwent TKA using a conventional alignment guide (control group). The coronal femoral component alignment (FCA), coronal tibial component alignment (TCA), and the hip-knee-ankle (HKA) angle were compared between groups. Intraoperative soft tissue balance, including the joint component gap and varus/valgus balance assessed by an offset-type tensor, were also compared between groups. One year postoperatively, the clinical outcomes, including the range of motion and 2011 Knee Society Score (KSS), were compared between groups. RESULTS: The HKA angle and FCA were 0.1° varus and 0.1° varus, respectively, in the robot group and 1.3° varus and 1.3° varus, respectively, in the control group. The difference in the HKA angle and the FCA, but not the TCA, between groups was statistically significant (p < 0.05). The intraoperative soft tissue balance showed more stable joint component gaps and varus/valgus balances throughout the range of motion in the robot group than in the control group. Clinical outcomes of the robot group showed superior 2011 KSS subscales compared to those of the control group. CONCLUSION: The accuracy of the implantations and stable soft tissue balance in the robot group were superior to those of the control group. The robot group also had superior patient-reported scores for early clinical outcomes.2023年06月, International orthopaedics, 47(6) (6), 1473 - 1480, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND Periprosthetic joint infection is a difficult complication, especially in patients with rheumatoid arthritis. Life-threatening septic shock due to periprosthetic joint infection caused by group G streptococcus is rare, and there have been few reports about its treatment. We describe a successful case of sudden onset septic shock due to group G Streptococcus infection after revision total knee arthroplasty. CASE REPORT A 61-year-old woman with rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs for about 12 years presented with acute right knee pain and shock 6 months after revision total knee arthroplasty. Periprosthetic joint infection caused by group G Streptococcus was diagnosed. She was admitted to the Intensive Care Unit, treated with respiratory support and dialysis, and underwent irrigation, debridement, and polyethylene liner exchange as the first surgery. At 9 days after the first surgery, she underwent the second surgery, consisting of implant removal and antibiotic spacer placement due to failure. It took approximately 7 weeks to normalize the levels of systemic markers of inflammation with intravenous antibiotics and then oral antibiotics for further 12 weeks, but re-revision total knee arthroplasty was successfully performed 1.5 years later. At a 1-year follow-up from the final surgery, she was able to walk with a cane and had no symptoms of infection. CONCLUSIONS In such cases with sudden onset of septic shock due to periprosthetic joint infection, appropriate and prompt surgical treatment should be performed to save the infected limb as well as the patient's life.2023年04月, The American journal of case reports, 24, e938905, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: The Masquelet technique is a relatively new method for large bone defect treatment. In this technique, grafted bone tissue is used, and after the cement is removed, the induced membrane (IM; that form around the cement spacers placed in the bone defect region) is thought to play an important role in promoting bone formation. On the other hand, low-intensity pulsed ultrasound (LIPUS) is known to promote fracture healing and angiogenesis through mechanical stimulation. This study aimed to investigate the in vitro effects of LIPUS on the osteogenic differentiation of human induced membrane-derived cells (IMCs). METHODS: Seven patients who had been treated using the Masquelet technique were enrolled. The IM was harvested during the second stage of the technique. IMCs were isolated, cultured in growth medium, and then divided into two groups: (1) control group, IMCs cultured in osteogenic medium without LIPUS, and (2) LIPUS group, IMCs cultured in osteogenic medium with LIPUS treatment. Adherent cells from the IM samples were harvested after the first passage and evaluated for cell surface protein expression using immunostaining. A cell proliferation assay was used to count the number of IMCs using a hemocytometer. Osteogenic differentiation capability was assessed using an alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and real-time reverse transcription-polymerase chain reaction. RESULTS: Cell surface antigen profiling revealed that the IMCs contained cells positive for the mesenchymal stem cell-related markers CD73, CD90, and CD105. No significant difference in cell numbers was found between the control and LIPUS groups. The ALP activity of IMCs in the LIPUS group was significantly higher than that in the control group on days 7 and 14. Alizarin red S staining intensity was significantly higher in the LIPUS group than in the control group on day 21. Runx2 and VEGF expression was significantly upregulated on days 7 and 14, respectively, compared with levels in the control group. CONCLUSION: We demonstrated the significant effect of LIPUS on the osteogenic differentiation of human IMCs. This study indicates that LIPUS can be used as an additional tool for the enhancement of the healing process of the Masquelet technique.2023年04月, Injury, 英語, 国際誌研究論文（学術雑誌）
- 2023年04月, 別冊整形外科, (83) (83), 139 - 142, 日本語
- (公社)日本整形外科学会, 2023年03月, 日本整形外科学会雑誌, 97(2) (2), S113 - S113, 日本語
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 526 - 526, 日本語疫学1:RA/関節型JIAの治療 高齢関節リウマチ患者における疾患活動性の年次変化に関する検討 関西多施設共同研究ANSWER Cohort study
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 551 - 551, 日本語JAK阻害薬-2 JAK阻害薬4剤の有効性比較と有効性に影響を与える因子の探索 関西多施設ANSWERコホートによる解析
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 603 - 603, 日本語生物学的製剤 IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 708 - 708, 日本語JAK阻害薬-7 多剤耐性マーカーMDR1遺伝子がJAK阻害薬の治療効果に与える影響について
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 774 - 774, 日本語IL-6刺激下でのJAK阻害剤の血管新生抑制効果の比較検討
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, 日本語RA患者由来線維芽細胞様滑膜細胞へのIL-6・TNFα刺激に対するJAK阻害剤の炎症抑制効果の比較検討
- (一社)日本リウマチ学会, 2023年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 67回, 873 - 873, 日本語軟骨細胞へのIL-6刺激に対するJAK阻害剤の効果
- Background: Symptomatic spinal metastasis (SSM) decreases the activities of daily living (ADL) and quality of life of cancer patients. However, the risk factors for SSM onset remain unclear. This prospective cohort study aimed to statistically analyze the significant risk factors. Methods: From 2016 to 2018, 210 consecutive patients with spinal metastases were prospectively registered. Patients with SSM at the first consultation and those who were unable to be followed-up owing to poor general condition were excluded. The demographic factors (age, sex, primary cancer, performance status, and ADL), clinical factors (radiation therapy, chemotherapy, molecularly targeted drugs, and bone-modifying agents (BMAs)), and Spinal Neoplastic Instability Score (SINS) were evaluated. Multivariate analysis was performed to identify the risk factors for SSM onset. Furthermore, the threshold was calculated from the receiver operating characteristic curve using the Youden index. Results: Thirty-nine patients who presented with SSM at the first consultation and 43 patients who were unable to be followed-up owing to poor general condition were excluded. Finally, 128 asymptomatic patients were included. Thirty-seven patients (28.9%) developed SSM during the follow-up period. The total SINS (OR: 1.739; 95% CI: 1.345-2.250) was identified as the most significant factor. The cut-off value of the SINS was 9.5 (sensitivity: 67.6%; specificity: 83.5%). Twenty-five (62.5%) of the forty patients with a SINS ≥ 10 developed SSM within a mean of 5.5 months (95% CI: 1.17-9.83). Furthermore, all patients with a SINS ≥ 13 developed SSM (n = 5) within a mean of 1.37 months (95% CI: 0.0-3.01). Conclusions: This study identified the significant risk factors for SSM onset and the threshold of the SINS. If long-term survival is expected, patients with a SINS ≥ 10 should be considered for intervention to prevent SSM.2023年02月, Cancers, 15(4) (4), 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION AND IMPORTANCE: Knee osteoarthritis with femoral and/or tibial extra-articular deformities makes total knee arthroplasty (TKA) technically difficult to perform, especially using intramedullary-based instrumentation systems. The Athena Knee 3-dimensional (3-D) image matching software is effective for TKA with an extra-articular deformity, especially in case of using a long-stem prosthesis or not available computer-assisted navigation systems. CASE PRESENTATION: A 79-year-old woman presented with right knee pain secondary to a progressive valgus deformity and gait disturbance. She had experienced a supracondylar femoral fracture fifteen years ago, and a tibial shaft fracture ten years ago on the same side; both of fractures were treated surgically. She had a severe valgus knee deformity and extra-articular deformity of femur and tibia, and valgus stress test detected medial knee instability. The range of motion was 0° in extension and 75° in flexion. Severe medial knee laxity compelled us to use a constrained and long-stem prosthesis, resulting in the use of an intramedullary guided system. The 3-D software system helped us to determine the amount of bone to cut as well as the appropriate entry points for the intramedullary rods and mechanical axis restoration. At two years after surgery, knee range of motion improved to 90° in flexion, and walking ability had also advanced from the use of two crutches to that of a T cane. CONCLUSION: The 3-D image matching software system for preoperative planning was useful for TKA with extra-articular deformity, especially in the case of a long-stem prosthesis without using a navigation system.2023年02月, International journal of surgery case reports, 103, 107853 - 107853, 英語, 国際誌
- Ewing sarcoma (ES) is an aggressive primary malignant bone tumor that predominantly affects children and young adults. Multimodal treatment approaches have markedly improved the survival of patients with localized ES. However, local recurrence and distant metastasis following curative therapies remain a main concern for patients with ES. Recent studies have suggested that slow‑cycling cells (SCCs) are associated with tumor progression, local recurrence and distant metastasis in various types of cancers. According to the results of these studies, it was hypothesized that SCCs may play a critical role in tumor progression, chemoresistance and local/distal recurrence in patients with ES. The present study applied a label‑retaining system using carboxyfluorescein diacetate succinimidyl ester (CFSE) to identify and isolate SCCs in ES cell lines. In addition, the properties of SCCs, including sphere formation ability, cell cycle distribution and chemoresistance, in comparison with non‑SCCs were investigated. RNA sequencing also revealed several upregulated genes in SCCs as compared with non‑SCCs; the identified genes not only inhibited cell cycle progression, but also promoted the malignant properties of SCCs. On the whole, the present study successfully identified SCCs in ES cells through a label‑retaining system using CFSE. Moreover, to the best of our knowledge, the present study is the first to describe the characteristic properties of SCCs in ES. The findings of this study, if confirmed, may prove to be useful in elucidating the underlying molecular mechanisms and identifying effective therapeutic targets for ES.2022年11月, International journal of oncology, 61(5) (5), 英語, 国際誌研究論文（学術雑誌）
- ABSTRACT Hepatitis B virus (HBV) infection can cause arthritis, but it is rarely reported. In the current report, we present a case of chronic polyarthritis in a patient with untreated HBV infection. A 63-year-old woman suffering from polyarthritis in her fingers visited our institution. She had experienced exacerbations and remissions of polyarthritis for more than 20 years. She had been diagnosed with rheumatoid arthritis and had been treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and nonsteroidal anti-inflammatory drugs by her primary care doctor, but the csDMARDs were discontinued at the request of the patient 10 years before the first visit to our hospital. The blood test showed negative for rheumatoid factor and anticyclic citrullinated peptides antibody but positive for hepatitis B surface antigen. Hepatitis B surface antigen and HBV-Deoxyribo Nucleic Acid (DNA) were increased to 312.6 (IU/ml) and 4.6 (log copies/ml), respectively. Based on the results of abdominal computed tomography and echography, she was diagnosed with liver cirrhosis. Treatment for HBV infection was begun with oral tenofovir at 25 mg/day. The polyarthritis in her fingers gradually disappeared and has not relapsed for 6 months after the initiation of treatment for HBV infection. When polyarthritis is diagnosed, the possibility that chronic HBV infection can be one of the causes of polyarthritis should be considered.Oxford University Press (OUP), 2022年10月, Modern Rheumatology Case Reports, 7(1) (1), 320 - 323研究論文（学術雑誌）
- Abstract The aim of the study is to explore and compare the differences in trochlear shape and knee anatomy between four types of prostheses and preoperative native knee matched with preoperative computed tomography (CT). Thirty patients were scheduled for primary kinematically aligned total knee arthroplasty (TKA) for varus knee osteoarthritis at our hospital and the region between their pelvis to ankle joint was simulated using a CT-based three-dimensional planning software. The axial plane containing the transepicondylar axis was set as Slice A, and the 10-mm distal plane from Slice A was set as Slice B. The distances to the deepest trochlear groove between the native knee and each prosthesis and the medial and lateral facet heights were compared among the four groups. The deepest femoral trochlear groove of the prostheses was located 1.6 to 3.0 mm more medial than that of the native knee, and in the Persona group, it was significantly more medial than in the e-motion or Triathlon groups on both Slices A and B. The native knee and the medial and lateral facet heights of the four prostheses on both Slices A and B were significantly lower than those of preoperative native knees when femoral prostheses were set in the kinematically aligned (KA)-TKA position. The deepest point of the trochlear groove of the Persona group was the most medial among the four prostheses studied, and the deepest points differed depending on the prosthesis design in KA-TKA. Thus, surgeons should carefully select the type of prostheses used in KA-TKA.Georg Thieme Verlag KG, 2022年09月, The Journal of Knee Surgery, 36(13) (13), 1316 - 1322研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2022年09月, Archives of Orthopaedic and Trauma Surgery, 143(6) (6), 3621 - 3627研究論文（学術雑誌）
- 2022年09月, Rheumatology: Current Research, 12(5) (5), 1000312, 英語[査読有り]研究論文（学術雑誌）
- The adipose-derived stromal vascular fraction (SVF) is composed of a heterogeneous mix of adipose-derived stem cells (ADSCs), macrophages, pericytes, fibroblasts, blood, and other cells. Previous studies have found that the paracrine effects of SVF cells may be therapeutic, but their role in osteoarthritis treatment remains unclear. This study aimed to investigate the therapeutic effect of SVF cells on chondrocytes. Chondrocytes were seeded on culture plates alone (control) or cocultured with SVF or ADSCs on cell culture inserts. After 48 h of coculture, chondrocyte collagen II, tissue inhibitors of metalloproteinases-3 (TIMP-3), and matrix metalloproteinases-13 (MMP-13) messenger RNA (mRNA) expression levels were evaluated using reverse-transcription polymerase chain reaction, and the transforming growth factor-β (TGF-β) levels in the supernatant were measured using ELISA. Immunohistochemical staining and flow cytometry were used to evaluate the macrophages in the SVF. These macrophages were characterized according to phenotype using the F4/80, CD86, and CD163 markers. To determine whether the Smad2/3 signaling pathways were involved, the chondrocytes were pre-treated with a Smad2/3 phosphorylation inhibitor and stimulated with the SVF, and then Smad2/3 phosphorylation levels were analyzed using western blot. The mRNA expression levels of various paracrine factors and chondrocyte pellet size were also assessed. Collagen II and TIMP-3 expression were higher in the SVF group than in the ADSC group and controls, while MMP-13 expression was the highest in the ADSC group and the lowest in the controls. TGF-β levels in the SVF group were also elevated. Immunohistochemical staining and flow cytometry revealed that the macrophages in the SVF were of the anti-inflammatory phenotype. Western blot analysis showed that the SVF increased Smad2/3 phosphorylation, while Smad2/3 inhibitors decreased phosphorylation. Smad2/3 inhibitors also reduced the expression of various other paracrine factors and decreased chondrocyte pellet size. These findings suggested that the paracrine effect of heterogeneous cells, such as anti-inflammatory macrophages, in the SVF partly supports chondrocyte regeneration through TGF-β-induced Smad2/3 phosphorylation.2022年09月, Journal of cellular physiology, 237(9) (9), 3627 - 3639, 英語, 国際誌研究論文（学術雑誌）
- Abstract Introduction Kinematically aligned total knee arthroplasty (KA-TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. One of the advantages of KA-TKA is reported to be an easy acquisition of intraoperative soft-tissue balance without excessive medial release for varus osteoarthritis. However, we hypothesized that the prosthesis type affects intraoperative soft-tissue balance even in the KA-TKA. The present study aimed to compare intraoperative soft-tissue balance and clinical outcomes of KA-TKAs using single-radius (SR) or multiradius (MR) prostheses. Materials and Methods Consecutive 70 cruciate-retaining modified KA-TKAs (31 SR and 39 MR) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative soft-tissue balance including joint component gap and varus/valgus balance was measured with femoral component placement and patellofemoral joint reduction throughout the range of motion using offset-type tensor and compared between the two groups. Two years postoperatively, the range of motion and 2011 Knee Society Scores were compared between the two groups. Results and Conclusion Joint component gaps showed no significant differences between the two groups from 0 to 30 degrees of flexion. However, during 60 to 120 degrees of flexion, joint component gaps of SR group showed significantly larger values than those of MR group (p < 0.05). There were no significant differences in varus/valgus balance throughout the range of motion between the two groups. The postoperative clinical outcomes showed no significant differences between the two groups. Interpretation Despite no difference in clinical outcomes, joint component gap showed different patterns due to the prosthesis type in modified KA-TKAs.Georg Thieme Verlag KG, 2022年07月, The Journal of Knee Surgery, 36(10) (10), 1013 - 1019研究論文（学術雑誌）
- Abstract The purpose of this study was to determine whether the transplantation of human cells from a non‐reattached injured anterior cruciate ligament (ACL) remnant could enhance tendon‐bone healing. Human ACL remnant tissue was classified into two groups based on the morphologic pattern as per Crain's classification: (1) non‐reattachment group (Crain Ⅳ) and (2) reattachment group (Crain Ⅰ–Ⅲ). Seventy‐five 10‐week‐old immunodeficient rats underwent ACL reconstruction followed by intracapsular administration of one of the following: (1) ACL‐derived cells from the non‐reattached remnant (non‐reattachment group) (n = 5), (2) ACL‐derived cells from the reattached tissue (reattachment group) (n = 5), or (3) phosphate‐buffered saline (PBS) only (PBS group) (n = 5). Histological (Weeks 2, 4, and 8), immunohistochemical (Week 2), radiographic (Weeks 0, 2, 4, and 8), and biomechanical (Week 8) assessments were performed. Histological evaluation showed high and early healing, induction of endochondral ossification‐like integration, and mature bone ingrowth at Week 4 in the non‐reattachment group. Microcomputed tomography at Week 4 showed that the tibial bone tunnels in the non‐reattachment group were significantly reduced compared to those in the reattachment and PBS groups. Moreover, biomechanical testing showed that ultimate load‐to‐failure in the non‐reattachment group tended to be larger than that in the reattachment group, though not statistically significant. The enhanced healing potential in the non‐reattachment group was explained by the increase in intrinsic angiogenesis/osteogenesis. In the subacute phase, the ACL‐derived cells with the non‐reattached morphologic pattern showed greater and earlier tendon bone healing compared with the cells obtained from the reattached morphologic pattern.Wiley, 2022年06月, Journal of Orthopaedic Research, 41(3) (3), 500 - 510研究論文（学術雑誌）
- BACKGROUND: This study aimed to compare the bone resection thickness, rate of minimal thickness insert usage, and postoperative range of motion (ROM) between robotic and navigated total knee arthroplasty (TKA). METHODS: Fifty consecutive posterior-stabilised (PS) robotic TKA and 50 case-controlled PS navigated TKA were enroled. Bone resection thickness, rate of minimal thickness insert usage, and postoperative flexion contracture over 5° were statistically compared. RESULTS: The tibial bone resection thickness was significantly thinner in robotic TKA. The insert thickness was significantly lower, and the rate of minimal thickness insert usage was significantly higher in robotic TKA. The ROM at 3 months postoperatively and the rate of postoperative flexion contracture were comparable between the two groups. CONCLUSION: Robotic TKA can reduce the tibial bone resection thickness and increase the rate of minimal thickness insert usage without increasing postoperative flexion contracture as compared with navigated TKA.2022年06月, The international journal of medical robotics + computer assisted surgery : MRCAS, 18(3) (3), e2370, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND Acute arterial occlusion after total knee arthroplasty (TKA) is a rare but occasionally limb-threatening complication. Successful outcomes of surgical treatment for acute arterial occlusion after TKA have been frequently reported in the literature; however, few reports have described conservative treatment. This case report describes the successful conservative treatment of popliteal artery occlusion after TKA. CASE REPORT We report 2 cases of popliteal artery occlusion after TKA that were managed with conservative treatment. In Case 1, a 68-year-old woman presented with a weak dorsalis pedis pulse in the foot and weakness to dorsiflexion of the toe on the operative side immediately after TKA. The operative lower extremity arterial ultrasonography and computed tomography angiography demonstrated the popliteal artery occlusion. In Case 2, a 79-year-old woman presented a cold right foot and lack of popliteal and dorsalis pedis pulse in the operated extremity immediately after TKA, and Doppler ultrasound did not reveal a flow for the dorsalis pedis artery. In both patients, urgent angiographies showed popliteal artery occlusion, and blood flow was observable in the anterior tibial, peroneal, and foot arteries collateral perfusion. Thus, conservative treatments were chosen, and anticoagulant and vasodilator therapies were undergone in both patients. At 6 months after surgery, they were able to walk without intermittent claudication. CONCLUSIONS Conservative treatment can be a good option for popliteal artery occlusion after TKA in cases of rich collateral circulation.2022年04月, The American journal of case reports, 23, e936295, 英語, 国際誌研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2022年04月, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 143 - 143, 日本語脂肪組織由来間質血管細胞群の軟骨細胞への作用機序の検討
- (一社)中部日本整形外科災害外科学会, 2022年04月, 中部日本整形外科災害外科学会雑誌, 65(春季学会) (春季学会), 158 - 158, 日本語大腿骨近位髄腔形状と人工骨頭置換術後のステム周囲の骨密度変化の関係について 多施設共同前向き観察研究
- BACKGROUND: To improve implant survival through accelerated early bone remodeling during total hip arthroplasty (THA), hydroxyapatite (HA) is widely used as a bioactive coating, which is believed to enhance initial fixation by osseointegration. We aimed to investigate the relationship between stem insertion alignment and postoperative bone mineral density (BMD) changes in patients with full hydroxyapatite-coated (HA) compaction short stem and short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 115 consecutive patients (115 joints) undergoing THA using the full HA compaction short (n = 59) and short tapered-wedge (n = 56) stems. Stem alignment, including anteversion, valgus, and anterior tilt were measured by a three-dimensional template using computed tomography data. Post-operative peri-prosthetic BMD was measured by dual-energy X-ray absorptiometry. The relationship between stem alignment and BMD changes in the stems was analyzed. RESULTS: Patterns of peri-prosthetic BMD changes were similar in both groups. Stem insertion alignments of anteversion, valgus, and anterior tilt were different between the two stem types. Stem alignment of valgus and anterior tilt did not affect peri-prosthetic BMD in either of the stem type. An absolute anteversion difference between stem anteversion and original canal anteversion caused significant peri-prosthetic BMD loss in Gruen zones one and seven in the tapered-wedge stem. However, stem alignment of absolute anteversion difference did not affect BMD changes in the HA compaction stem. CONCLUSIONS: Peri-prosthetic bone remodeling remained unaffected by stem alignment after THA with the new short full HA compaction stem.2022年03月, Journal of orthopaedic surgery and research, 17(1) (1), 131 - 131, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本整形外科学会, 2022年03月, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, 日本語
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 341 - 341, 日本語リウマチ性疾患のヒト免疫研究 N-アセチルガラクトサミン転移酵素12(GalNAc-T12)の軟骨細胞への影響の検討
- (公社)日本整形外科学会, 2022年03月, 日本整形外科学会雑誌, 96(2) (2), S233 - S233, 日本語
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 341 - 341, 日本語リウマチ性疾患のヒト免疫研究 N-アセチルガラクトサミン転移酵素12(GalNAc-T12)の軟骨細胞への影響の検討
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 568 - 568, 日本語関節リウマチ患者における痛み受容チャネルTRPA1ミスセンス変異と疾患活動性との関連
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 570 - 570, 日本語多剤耐性因子MDR1発現がJAK阻害薬治療効果に与える影響の検討
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 588 - 588, 日本語IL-6阻害薬は骨びらんによる関節破壊の進行を優位に抑制する
- (一社)日本リウマチ学会, 2022年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 66回, 615 - 615, 日本語RA患者由来滑膜線維芽細胞へのIL-6刺激に対するJAK阻害剤の効果の比較検討
- (公社)日本整形外科学会, 2022年03月, 日本整形外科学会雑誌, 96(3) (3), S699 - S699, 日本語
- PURPOSE: To evaluate the relationship between morphological differences in labral tears and clinical features of the hip joint in patients who underwent hip arthroscopy. MATERIALS AND METHODS: We retrospectively analyzed data from patients who underwent arthroscopic surgery for the treatment of labral tears. Hip labral tears were morphologically classified as longitudinal peripheral tears (group L), radial fibrillated tears (group FI), radial flaps (group FL), and an unstable labrum (group U). Radiographically, the center-edge angle, acetabular roof obliquity, vertical-center-anterior angle, alpha angle, femoral head-neck offset ratio, and crossover sign were evaluated and compared among the groups. The relationship between labral morphology and these radiographic findings, as well as clinical findings, such as age, gender, preoperative range of hip motion, and the clinical outcomes using modified Harris Hip Score (mHHS) were also examined. RESULTS: This study included fifty patients. Groups L and FI were often observed in late middle-aged patients with relatively shallow acetabular coverage. Group FL tears were frequently observed in young males with radiographic features, such as femoroacetabular impingement (FAI), compared to the other groups. Group U comprised mostly young females with relatively shallow acetabular coverage compared to the other groups. For the postoperative mHHS, group FL showed the best score among all groups, with a significant difference between groups FL and FI (p = 0.034). CONCLUSIONS: Our study revealed that morphologically, different labral tears were associated with different clinical features and radiological findings. Especially, our study can provide predictive findings for hip arthroscopists that younger males with FAI show better clinical outcomes when compared to middle-aged females with shallow acetabulum, which is indicative of degenerative hip labral tears. LEVEL OF EVIDENCE: IV case series.2022年02月, Indian journal of orthopaedics, 56(2) (2), 295 - 302, 英語, 国際誌研究論文（学術雑誌）
- The use of induced pluripotent stem cells (iPSCs) shows potential in bone regenerative strategies. In this study, we investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) can lead to successful bone regeneration in nude mice with bone defects. Two human iPSC clones (201B7 and 454E2) were used. After generating iMSCs, chondrogenic differentiation was achieved by three-dimensional pellet culture. Thereafter, a 2-mm defect was created in the radius of nude mice, and chondrogenically differentiated iMSC pellets were transplanted in the defect. Microcomputed tomography imaging was performed 8 weeks posttransplantation to assess bone regeneration. All (100%) radii in the 201B7 cell-derived pellet transplantation group and 7 of 10 (70%) radii in the 454E2 cell-derived pellet transplantation group showed bone union. In contrast, 2 of 11 radii (18%) in the control group showed bone union. Thus, the experimental groups showed significantly higher bone union rates than the control group (p < 0.05). Histological analysis 2 weeks postimplantation in the experimental groups revealed hypertrophic chondrocytes within grafted iMSC pellets and the formation of woven bone around them. This hypertrophic chondrocyte transitioning to newly formed bone suggests that the cartilaginous template can trigger endochondral bone ossification (ECO). Four weeks postimplantation, the cartilage template was reduced in size; newly formed woven bone was predominant in the defect site. New vessels were surrounded by a matrix of woven bone, and hypertrophic chondrocytes transitioning to newly formed bone indicated the progression of ECO. Eight weeks postimplantation, the pellets were completely resorbed and replaced by bone; complete bone union was observed. Dense mature bone developed with evidence of lamellar-like bone formation. Collectively, our results suggest that using iMSC-based cartilage grafts recapitulating the morphogenetic process of ECO in the context of embryonic skeletogenesis is a promising strategy for repairing large bone defects. Impact statement We investigated whether implantation of chondrogenically differentiated iPSC-derived mesenchymal stem cells (iMSCs) could lead to the successful regeneration of bone defects in vivo. We implanted two different clones of human induced pluripotent stem cells into a radial bone defect model. Eleven of 11 (100%) and 7 of 10 (70%) radii in the 201B7 and 454E2 cell-derived pellet transplantation groups, respectively, showed bone union, which were significantly higher than those in the control group [only 2 of 11 radii (18%)]. Overall, our results support the use of iMSC-based cartilage grafts recapitulating the morphogenetic process of endochondral bone ossification for repairing large bone defects.2022年02月, Tissue engineering. Part A, 28(3-4) (3-4), 184 - 195, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Femoroacetabular impingement (FAI) after periacetabular osteotomy (PAO) may be affected by both anterior acetabular coverage and femoral head shape. This study aimed to radiographically evaluate the relationship of the combination of acetabular coverage and femoral head shape with the occurrence of FAI after curved PAO. METHODS: In this study, 76 hip joints from patients with symptomatic developmental dysplasia of the hip underwent curved PAO. The relationship between the combined postoperative anterior center-edge and alpha angles (ie, the combination angle) and the occurrence of postoperative FAI was evaluated. Clinical factors and the preoperative and postoperative 3-dimensional center-edge angles, acetabular versions, femoral versions, radiographic alpha angles of the femoral head, and the combination angle were measured and compared to clinical outcomes. RESULTS: The modified Harris Hip Scores, University of California, Los Angeles activity scores, and acetabular coverage angles were significantly improved following curved PAO. Receiver operator characteristic curve analysis demonstrated that the combination angle over 108° may be a predictive factor for the occurrence of FAI after curved PAO. Multivariate analysis demonstrated that an age <40 years (odds ratio 6.6, 95% confidence interval 1.2-36.4, P = .037) and a combination angle <108° (odds ratio 9.2, 95% confidence interval 1.7-50.0, P = .010) were significantly associated with modified Harris Hip Scores ≧90 points. CONCLUSION: A combination angle >108° may be a predictive factor for the occurrence of FAI after curved PAO and impaired clinical outcomes. To avoid postoperative FAI, we propose that osteochondroplasty of the femoral head should be performed for patients with preoperative combination angles >90°.2022年02月, The Journal of arthroplasty, 37(2) (2), 219 - 225, 英語, 国際誌研究論文（学術雑誌）
- Recently, reamer-irrigator-aspirator (RIA) systems have been increasingly used to harvest autologous bone grafts. RIA graft materials contain bone marrow, which provides a viable source to derive large numbers of mesenchymal stem cells. Low-intensity pulsed ultrasound (LIPUS) significantly accelerates the differentiation of stem cells derived from bone marrow. This in vitro study investigated the effect of LIPUS on the osteogenic activity and differentiation of RIA graft-derived cells. A small amount of RIA graft was obtained from seven patients. After the cells derived from RIA grafts were cultured, they were divided into two groups: the LIPUS and control groups. LIPUS was applied once daily for 20 min (1.5 MHz, pulse duration: 200 µs, pulse repetition rate: 1 kHz, spatial average-temporal average intensity: 30 mW/cm2). Alkaline phosphatase activity (113.4% and 130.1% on days 7 and 14), expression of osteoblast-related genes (ALP, Runx2) and mineralization (135.2% on day 21) of the RIA graft-derived cells were significantly higher in the LIPUS group than in the control group. However, LIPUS did not affect the cell proliferation of RIA graft-derived cells. This study indicates that LIPUS may enhance the healing of non-union and critical bone defects treated by autologous bone grafting using the RIA system.2022年02月, Ultrasound in medicine & biology, 48(2) (2), 313 - 322, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: To investigate the cell types that undergo apoptosis in TNF-α inhibitor (TNFI)- and IL-6 inhibitor (IL-6I)-treated synovia of RA patients, and to observe and compare histological changes in them. METHODS: Synovial tissue was collected during total knee arthroplasty from 20 RA patients who were divided into three groups based on RA treatment received: conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs, control group), TNFI, or IL-6I. Tissue samples were subjected to haematoxylin and eosin staining, terminal deoxynucleotidyl transferase fluorescein-deoxyuridine triphosphate nick end labelling (TUNEL), immuno-histochemistry (IHC) and immunofluorescence staining for, respectively, histopathological assessment, apoptosis detection and IHC evaluation and scoring. RESULTS: TUNEL-positive cells were detected surrounding the discoid fibrosis unique to the TNFI group, while those in the IL-6I group were distributed widely, especially surrounding the blood vessels. IHC revealed that in TNFI-treated tissue, CD86- and CD80-positive cells were detected only in the lining and sublining layer, while CD163- and CD206-positive cells were detected more broadly; in the IL-6I-treated tissue, all four were detected widely but their levels were lower than in the control group. Immunofluorescence also revealed macrophages mainly were the apoptotic cells in the lining and sublining layers of TNFI group. TUNEL Expression levels of CD20- and CD3-positive cells were remarkably lower in the IL-6I group, compared with the control and TNFI groups. CONCLUSIONS: TNFIs and IL-6Is target different action sites and synovial cell types, resulting in histopathological features of synovium distinct from one another.2022年01月, Clinical and experimental rheumatology, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Changes in bone mineral density (BMD) around the fully hydroxyapatite (HA)-coated compaction broached and triple-tapered stem, namely, Polarstem, after total hip arthroplasty (THA) are currently unknown. Therefore, the aims of this study were to investigate clinical outcomes of Polarstem, mainly postoperative temporal changes in BMD around the stem for 2 years, and to compare them with those of HA-coated and non-HA-coated tapered-wedge stems. METHODS: This retrospective cohort study enrolled 100 consecutive patients who underwent THA using Polarstem (n = 38), HA-coated Anthology (n = 31), and non-HA-coated Anthology (n = 31). BMD was evaluated using dual-energy X-ray absorptiometry in seven regions according to the Gruen zones. Postoperatively, BMD around the stem was assessed within 2 months (baseline BMD) and at 6, 12, and 24 months. A change in BMD was defined as the value calculated by dividing each postoperative BMD value at 6, 12, and 24 months by the baseline BMD value. Changes in BMD and radiographic parameters such as stress shielding and spot welds were compared among the three stems. RESULTS: The incidence rate of stress shielding in the Polarstem group was significantly lower than those in the other two groups (p = 0.007). The change in BMD in Zone 7 of Polarstem was significantly more than that of the other two groups at 12 and 24 months postoperatively (p = 0.030 and p = 0.009, respectively). CONCLUSION: Polarstem, a fully HA-coated compaction broached and triple-tapered stem, maintained BMD around the femoral calcar until 2 years postoperatively and could reduce the risk of stress shielding compared with tapered-wedge stems.2022年01月, Archives of orthopaedic and trauma surgery, 142(12) (12), 4087 - 4093, 英語, 国際誌研究論文（学術雑誌）
- The aim of this simulation study was to evaluate the relationship of elements of anterior acetabular coverage and femoral head-neck shape with the occurrence of postoperative anterior impingement after curved periacetabular osteotomy (PAO). Sixty-two patients with symptomatic developmental dysplasia of the hip who had undergone curved PAO were selected. The likelihood of developing postoperative anterior impingement was explored through simulations of the range of motion by collision detection of the pelvis and femur. Postoperative anterior impingement was defined as impingement that occurred during postoperative bone flexion <105° or postoperative internal rotation <20° at 90° flexion. The three-dimensional center-edge (CE) angles, acetabular and femoral versions, radiographic alpha angles of the femoral head, combination angles of anterior CE and alpha angles, and combined anteversions of acetabular and femoral versions were compared between patients with postoperative anterior impingement and nonimpingement. A receiver operator characteristic (ROC) analysis was conducted to determine thresholds of the examined radiographic parameters and calculate their accuracy for predicting postoperative anterior impingement. A multivariate analysis was performed to test whether combined anteversion, anterior CE angle, and combination angle are associated with excellent modified Harris Hip Scores (mHHSs). ROC analysis demonstrated a combination angle ≥108° was predictive of the occurrence of postoperative anterior impingement after curved PAO, which can lead to impaired clinical outcomes. Conversely, a combination angle <108° was significantly associated with mHHS ≥ 90 points. To avoid postoperative anterior impingement, osteochondroplasty of the femoral head or anterior CE angle control should be performed for patients with preoperative combination angles ≥90°.2022年01月, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Induced membrane (IM) is the key component of Masquelet reconstruction surgery for the treatment of bone defects. IM is formed around the cement spacer and is known to secrete growth factors and osteoinductive factors. However, there is limited evidence available concerning the presence of osteoinductive factors in IM. This study aimed to investigate the existence of bone morphogenetic proteins (BMPs) in IM harvested from patients during the treatment of bone defects using the Masquelet technique. METHODS: This study involved six patients whose bone defects had been treated using the Masquelet technique. The affected sites were the femur (n = 3) and the tibia (n = 3). During the second-stage surgery, 1 cm2 pieces of IM were harvested. Histological sections of IM were immunostained with anti-BMP-4, 6, 7, and 9 antibodies. Human bone tissue served as the positive control. RESULTS: The presence of BMP-4, 6, 7, and 9 was observed in all IM samples. Further, immunolocalization of BMP-4, 6, 7, and 9 was observed in blood vessels and fibroblasts in all IM samples. Immunolocalization of BMP-4, 6, 7, and 9 was also observed in bone tissue within the IM in one sample, in which osteogenesis inside the IM was observed. CONCLUSIONS: This study showed that osteoinductive factors BMP-4, 6, 7, and 9 were present in the IM harvested from patients, providing evidence indicating that the Masquelet technique effectively contributes to healing large bone defects. Therefore, it may be possible for surgeons to omit the addition of BMPs to bone grafts, given the endogenous secretion of BMPs from the IM.2022年01月, Journal of orthopaedic surgery and research, 17(1) (1), 29 - 29, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: It is generally believed that contraction of the soft tissue structures on the medial side may occur in the knee with severe varus deformity. However, the relationship between the severity of varus deformity of the knee and the intraoperative soft tissue balance in unicompartmental knee arthroplasty (UKA) has not been well reported thus far. METHODS: One hundred and three consecutive medial UKAs were enrolled. After the femoral trial prosthesis was placed, the component gap was measured at 10° (extension) and 120° (flexion) of flexion using a UKA tensor. The pre-osteotomy gap was then calculated from the thickness of the bone cut. Paired Student's t-test was used to compare the component gap, as well as the pre-osteotomy gap, in extension and those in flexion. The relationship between the preoperative Hip-Knee-Ankle (HKA) angle and the pre-osteotomy gap was analysed using Pearson's correlation coefficient and simple linear regression analysis. RESULTS: The component gap in extension was significantly smaller than that in flexion while the pre-osteotomy gap in extension was significantly wider than that in flexion. There was a positive correlation between the severity of varus deformation in preoperative knee and the pre-osteotomy gap in extension, while there was no correlation between the preoperative HKA angle and the pre-osteotomy gap in flexion. CONCLUSIONS: The tension of the medial tightness does not correlate with the degree of preoperative varus deformity in UKA.2021年10月, The Knee, 32, 90 - 96, 英語, 国際誌研究論文（学術雑誌）
- AIMS: This study aimed to evaluate the accuracy of implant placement with robotic-arm assisted total hip arthroplasty (THA) in patients with developmental dysplasia of the hip (DDH). METHODS: The study analyzed a consecutive series of 69 patients who underwent robotic-arm assisted THA between September 2018 and December 2019. Of these, 30 patients had DDH and were classified according to the Crowe type. Acetabular component alignment and 3D positions were measured using pre- and postoperative CT data. The absolute differences of cup alignment and 3D position were compared between DDH and non-DDH patients. Moreover, these differences were analyzed in relation to the severity of DDH. The discrepancy of leg length and combined offset compared with contralateral hip were measured. RESULTS: The mean values of absolute differences (postoperative CT-preoperative plan) were 1.7° (standard deviation (SD) 2.0) (inclination) and 2.5° (SD 2.1°) (anteversion) in DDH patients, and no significant differences were found between non-DDH and DDH patients. The mean absolute differences for 3D cup position were 1.1 mm (SD 1.0) (coronal plane) and 1.2 mm (SD 2.1) (axial plane) in DDH patients, and no significant differences were found between two groups. No significant difference was found either in cup alignment between postoperative CT and navigation record after cup screws or in the severity of DDH. Excellent restoration of leg length and combined offset were achieved in both groups. CONCLUSION: We demonstrated that robotic-assisted THA may achieve precise cup positioning in DDH patients, and may be useful in those with severe DDH. Cite this article: Bone Joint Res 2021;10(10):629-638.2021年10月, Bone & joint research, 10(10) (10), 629 - 638, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Lateral compartment osteoarthritis progression (LOP) is a major complication after Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study aimed to identify the association between tibiofemoral subluxation (TFS) and LOP after OUKA. Patients whose TFS was uncorrectable according to preoperative stress radiographs were hypothesised to develop residual TFS even after surgery, and thought to be more likely to develop LOP. METHODS: The study included 201 patients who underwent medial OUKA. Fifteen patients showed increases in LOP of at least two Kellgren-Lawrence grades after surgery [progression (P) group], while the others had no progression (N group, n = 186). TFS was measured on preoperative full leg weight-bearing radiographs, valgus stress radiographs and postoperative plain radiographs. Valgus stress radiographs were obtained using a firm manual valgus force with the knee flexed at 20°. Leg alignment, Oxford knee score (OKS), and revision rates were assessed. RESULTS: The P group had significantly higher TFS values on preoperative valgus stress (6.8° ± 2.2° vs. 4.5° ± 2.0°; P < 0.001) and postoperative radiographs (6.6° ± 2.3° vs. 4.6° ± 2.9°; P < 0.001) than the N group. Patients with postoperative residual TFS and postoperative valgus alignment were more likely to have LOP, but 9 of the 15 LOP patients did not show postoperative valgus alignment. The P group had significantly poorer postoperative OKS (33.0 ± 10.2 vs. 37.4 ± 6.5, P = 0.017) and a higher rate of revision (6/15 vs 6/186; odds ratio = 19.16; 95% CI = 4.98-76.05, P < 0.001). CONCLUSION: OA progression in the lateral compartment after medial OUKA might be associated with postoperative residual TFS, but does not always coexist with postoperative valgus alignment. Preoperative assessment of TFS with valgus stress could be a potential predictor of postoperative residual TFS and LOP. LEVEL OF EVIDENCE: Level III.2021年09月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(9) (9), 3236 - 3243, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: The presence of tibiofemoral subluxation (TFS) in patients with unicompartmental arthritis, a potential contraindication to unicompartmental knee arthroplasty (UKA), remains controversial and is not commonly discussed. This study aimed to determine the predictability of postoperative TFS before surgery and the effect of TFS on clinical outcomes after fixed-bearing UKA. MATERIALS AND METHODS: In total, 70 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA from January 2015 to January 2017 were included. The preoperative TFS was assessed using plain anteroposterior and valgus stress radiographs. The patients were classified into three groups as follows: group A (acceptable TFS, n = 36) comprising patients with preoperative TFS less than 5.0 mm; group C (correctable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm but corrected to less than 5.0 mm under valgus stress; and group U (uncorrectable TFS, n = 17) comprising patients with preoperative TFS of more than 5.0 mm under valgus stress. Patient-derived clinical scores were assessed with the 2011 Knee Society Score preoperatively and 2 years postoperatively. The results were compared among the three groups using analysis of variance. RESULTS: Group U showed significantly higher postoperative TFS than groups A and C. Improvements in "symptoms" and "patient satisfaction" scores 2 years after surgery were significantly higher in groups A and C than in group U. CONCLUSION: Preoperative assessment of TFS under valgus stress could be a predictor of postoperative TFS. Furthermore, preoperative uncorrectable TFS could increase pain and decrease patient satisfaction 2 years after undergoing fixed-bearing UKA.2021年09月, Archives of orthopaedic and trauma surgery, 英語, 国際誌研究論文（学術雑誌）
- Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissues leads to the formation of pannus that invades the joint cartilage and bone, resulting in joint destruction. Fas ligand (FasL), which is a member of the tumor necrosis factor superfamily, contributes to the pathogenesis of autoimmune diseases, including RA. The current study attempted to identify genes whose expressions in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by FasL, using cDNA microarray. A total of four individual lines of primary cultured RA-FLS were incubated either with recombinant human FasL protein or PBS as an unstimulated control for 12 h. Gene expression was detected using a microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by Fas and investigated the functions of the genes that were regulated. Among the genes in this profile, the mRNA expression changes of the following genes were indicated to be of note using RT-qPCR: Dual specificity phosphatase 6, epiregulin, interleukin 11, angiopoietin-like 7, protein inhibitor of activated STAT 2 and growth differentiation factor 5. These genes may affect the pathogenesis of RA by affecting apoptosis, proliferation, cytokine production, cytokine-induced inflammation, intracellular signaling, angiogenesis, bone destruction and chondrogenesis. To the best of our knowledge, the current study is the first study to reveal the expression profile of genes in RA-FLS regulated by FasL. The data demonstrated that FasL may regulate the expression of a number of key molecules in RA-FLS, thus affecting RA pathogenesis. Further studies of the genes detected may improve the understanding of RA pathogenesis and provide novel treatment targets for RA.2021年09月, Experimental and therapeutic medicine, 22(3) (3), 1000 - 1000, 英語, 国際誌研究論文（学術雑誌）
- Outcomes of total knee replacement with the use of a NexGen MIS Tibial Component (Mini-keel) : a systematic review.NexGen MIS Tibial Component (Mini-keel) is a tibial component specially developed for minimally invasive surgery in total knee replacement (TKR), and the size limitations of its design and the modular system could affect tibial fixation strength, however, this has not been precisely evaluated thus far. This study aimed to systematically review the literature describing the outcome following TKR with the use of a Mini-keel. Electronic searches of databases were undertaken in July 2019 by two experienced orthopaedic surgeons according to the PRISMA guidelines for literature describing the outcomes of TKR with the use of a Mini-keel. Quality of studies was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. The initial search found a total of 623 studies from all the databases. Seven studies met all the inclusion criteria and were eligible for critical appraisal and quality assessment. In total, 2,198 cases were included in the systematic review. Thirty-five revision cases due to aseptic loosening were found from the systematic review. Two studies were negative about using a Mini-keel and three studies were positive about it, while the other two studies did not judge the quality of a Mini-keel. There have been conflicting conclusions among studies for the use of a Mini-keel. There remains a paucity of prospective cohort studies between TKRs with the use of a Mini-keel and those with the use of a conventional implant, which makes it difficult to determine the usefulness and reliability of this implant.2021年09月, Acta orthopaedica Belgica, 87(3) (3), 469 - 478, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: We aimed to investigate the differences in peri-prosthetic bone remodelling between the full hydroxyapatite (HA)-collared compaction short stem and the short tapered-wedge stem. METHODS: This retrospective cohort study enrolled 159 consecutive patients (159 joints) undergoing total hip arthroplasty (THA) using the full HA compaction short (n = 64) and short tapered-wedge (n = 95) stems. Body mass index (BMI), peri-prosthetic bone mineral density (BMD), and clinical factors, including the Japanese Orthopaedic Association score and the University of California Los Angeles (UCLA) activity score were assessed and compared. RESULTS: Stem related complications were seen in three cases. Both groups showed similar peri-prosthetic BMD changes. Peri-prosthetic BMD was almost maintained in the distal femur and Gruen zone 6 with both type of stems, but significant BMD loss was found in zones 1 and 7 in both groups and in zone 2 of the full HA compaction stem group. No significant correlations were found between the proximal femoral BMD changes and the age, BMI, and UCLA score in both the full HA compaction and tapered-wedge stem groups. Femoral bone shape affected the peri-prosthetic BMD changes in the tapered-wedge stem group but not in the full HA compaction group. The stem collar of the full HA compaction stem did not affect peri-prosthetic BMD, but unique bone remodelling in the calcar region was observed in 27.6% cases. A significant difference in the peri-prosthetic BMD changes at Gruen zone 2 was found in patients with or without thigh pain. CONCLUSION: Peri-prosthetic bone remodelling remained unaffected by clinical and radiographic factors after THA with the new short full HA compaction stem. Therefore, this new stem may be useful in a variety of cases.2021年08月, Archives of orthopaedic and trauma surgery, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本整形外科学会, 2021年08月, 日本整形外科学会雑誌, 95(8) (8), S1732 - S1732, 日本語人工知能モデルによる関節リウマチへの生物学的製剤治療効果の予測
- We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we determined the mechanism underlying the effect of p21 in synovial and cartilage tissues in RA. The knee joints of p21-knockout (p21-/-) (n = 16) and wild type C57BL/6 (p21+/+) mice (n = 16) served as in vivo models of collagen antibody-induced arthritis (CAIA). Arthritis severity was evaluated by immunological and histological analyses. The response of p21 small-interfering RNA (siRNA)-treated human RA FLSs (n = 5 per group) to interleukin (IL)-1β stimulation was determined in vitro. Arthritis scores were higher in p21-/- mice than in p21+/+ mice. More severe synovitis, earlier loss of Safranin-O staining, and cartilage destruction were observed in p21-/- mice compared to p21+/+ mice. p21-/- mice expressed higher levels of IL-1β, TNF-α, F4/80, CD86, p-IKKα/β, and matrix metalloproteinases (MMPs) in cartilage and synovial tissues via IL-1β-induced NF-kB signaling. IL-1β stimulation significantly increased IL-6, IL-8, and MMP expression, and enhanced IKKα/β and IκBα phosphorylation in human FLSs. p21-deficient CAIA mice are susceptible to RA phenotype alterations, including joint cartilage destruction and severe synovitis. Therefore, p21 may have a regulatory role in inflammatory cytokine production including IL-1β, IL-6, and TNF-α.2021年06月, Scientific reports, 11(1) (1), 12516 - 12516, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The relationship between the femoral component design in total knee arthroplasty (TKA) and the patellofemoral contact force, as well as the soft tissue balance, has not been well reported thus far. METHODS: Twenty-eight mobile-bearing posterior-stabilized (PS) TKAs using the traditional model (PFC Sigma) and 27 mobile-bearing PS TKAs using the latest model (Attune) were included. Surgeries were performed using the measured resection technique assisted with the computed tomography (CT)-based free-hand navigation system. After all the trial components were placed, patellar contact forces on the medial and lateral sides were measured using two uniaxial ultrathin force transducers with the knee at 0°, 10°, 30°, 60°, 90°, 120°, and 135° of flexion. The joint component gap and the varus ligament balance of the femorotibial joint were also measured. The non-paired Student's t-test was conducted to compare the values of the two groups. RESULTS: The medial patellar contact force was significantly lower for Attune group than for PFC Sigma group at 120° of knee flexion (P = 0.0058). The lateral patellar contact force was also significantly lower for Attune group than PFC Sigma group at 120° and 135° of knee flexion (P = 0.0068 and P = 0.036). The joint component gap, as well as the varus ligament balance, showed no statistically significant difference between the two groups. CONCLUSIONS: Reduced thickness and width of the anterior flange of the femoral component in the Attune may play a role in low patellar contact force.2021年06月, The Knee, 30, 1 - 8, 英語, 国際誌研究論文（学術雑誌）
- Introduction: The concept of anatomic restoration has garnered considerable interest in the form of kinematically aligned total knee arthroplasty (KA-TKA). KA-TKAs have been reported to reproduce natural alignment and kinematics. However, few randomized controlled trials (RCTs) have compared the biomechanical outcomes and the long-term clinical outcomes of KA-TKA with those of mechanically aligned TKA (MA-TKA). We aim to investigate the long-term clinical and biomechanical effects of KA-TKA and to determine whether KA-TKA or MA-TKA is more appropriate for primary TKA. Methods: This trial will compare clinical and biomechanical outcomes of KA-TKA to those of MA-TKA. Two hundred patients will be enrolled in the RCT and randomized into KA-TKA or MA-TKA groups. Both the groups will be evaluated 1 week before the operation, on the day of the operation, 6 months after the operation, and 1, 5, and 10 years after the operation. The primary outcome is the difference between preoperative and 1-year postoperative functional activity scores of the 2011 Knee Society Score (2011 KSS) in both groups as well as the differences between the scores of both groups. The secondary outcomes will include differences in symptom, satisfaction, and expectation scores of the 2011 KSS, intraoperative kinematics evaluation, postoperative clinical outcomes and complications, pre- and postoperative gait analyses and radiograph evaluations between both KA-TKA and MA-TKA.2021年06月, Contemporary clinical trials communications, 22, 100775 - 100775, 英語, 国際誌研究論文（学術雑誌）
- Lower extremity alignment is very important after total knee arthroplasty (TKA). This study aimed to compare the plantar pressure distribution while walking and the overall limb alignment, including the hindfoot, between kinematically (KA) and mechanically aligned (MA) TKA. The plantar pressure distribution was investigated using a pressure plate during walking and one-leg standing among four groups: patients one year after KA-TKA (KA group; n = 25), patients one year after MA-TKA (MA group, n = 25), patients with osteoarthritis (OA) undergoing non-surgical care (OA group, n = 25), and healthy controls (Healthy group; n = 25). Conventional and true mechanical axes (the line from the femoral head to the lowest point of the calcaneus) were evaluated on unipedal standing long-leg radiographs in the KA, MA, and OA groups. Results were compared using analysis of variance. The OA group showed a lateral loading pattern in the mid- and rearfoot, while the MA group showed a medial rearfoot loading pattern during walking. On the contrary, the KA and Healthy groups showed an almost equal pressure distribution between the medial and lateral rearfoot. Moreover, although both mechanical axes in the KA group passed through the knee more medially, a more neutral alignment was achieved in the true mechanical axis compared to that in the MA group. KA-TKA results in more neutral weight-bearing through the true mechanical axis and allows patients to walk while maintaining medial and lateral rearfoot pressure more evenly than MA-TKA.2021年05月, Journal of biomechanics, 120, 110379 - 110379, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The aim of this study was to evaluate the association between labral length and radiographic parameters of lateral and anterior acetabular coverage and the femoro-epiphyseal acetabular roof (FEAR) index in patients with developmental dysplasia of the hip (DDH). METHODS: We retrospectively analyzed data from patients with DDH who visited our hip joint clinic for the first time due to hip symptoms. DDH presence was defined as a lateral center-edge angle (LCEA) of ≤25°. The labral lengths on the anterior and lateral sides were measured on central axial and central coronal slices of T1-weighted magnetic resonance imaging, respectively. The Pearson correlation coefficients (r) and simple linear regression analyses were performed to determine the association of the lateral and anterior labral lengths with the radiographic parameters, including the LCEA, acetabular roof obliquity, FEAR index, anterior wall index, and vertical center anterior angle. RESULTS: This study included 88 patients, with a mean age of 39.6 ± 11.8 years. There were 65 women and 23 men. The lateral and anterior labral lengths correlated with all parameters of dysplasia. Specifically, the lateral labral length had a strong positive correlation with the FEAR index (R = 0.65, P < .001). The anterior labral length had a strong negative correlation with the anterior wall index (R = -0.66, P < .001). CONCLUSIONS: The lateral labral length had a strong positive correlation with the FEAR index. Furthermore, the anterior labral length had a correlation with the anterior dysplasia. LEVEL OF EVIDENCE: Level III, retrospective cross-sectional study.2021年05月, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: A reamer irrigator aspirator (RIA) can be used to harvest substantial amounts of autologous bone and debride the intramedullary canal. Clinical experience using reamer irrigator aspirators in Japan is very limited. The applicability of the reamer irrigator aspirator head with a minimum diameter of 12 mm for Japanese people is often questioned as the Japanese are smaller than Americans and Europeans. There are no reports of complications in Japanese patients. This study aimed to retrospectively review clinical cases and describe reamer irrigator aspirator use in Japanese patients. METHODS: All patients for whom a reamer irrigator aspirator was used during surgery at our hospital between January 2014 and September 2018 were included. The patients' clinical and radiographic data were retrospectively reviewed. RESULTS: Data of 40 patients (42 cases) were collected. The reamer irrigator aspirator was used for bone graft harvesting in 32 cases, intramedullary debridement and irrigation in 9 cases, and reaming for exchange nailing in 1 case. The diameter of the reamer irrigator aspirator reamer head was 12 mm in 22 cases (53.7%), 12.5 mm in 4 cases (9.8%), 13 mm in 9 cases (22.0%), 13.5 mm in 1 case (2.4%), 14.0 mm in 1 case (2.4%), 14.5 mm in 1 case (2.4%), and 15 mm in 4 cases (9.8%). Mean intraoperative bleeding volume was 1158.6 mL (range, 100-3800 mL). We experienced no difficulty inserting the reamer irrigator aspirator into the intramedullary canals and no cases of insertion-related intraoperative fracture. Five cortical perforations (11.9%) were observed on postoperative computed tomography scans, although no patient was symptomatic. One case (2.4%) of postoperative femur fracture occurred. CONCLUSIONS: Reamer irrigator aspirators can be used in Japanese patients. Smaller reamer head sizes were mainly used in our experience. We should manage complications as in previous reports from Western countries.2021年05月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 26(3) (3), 459 - 465, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: The aim of this study was to systematically review the existing literature comparing the postoperative outcomes after following hip arthroscopy in obese and non-obese patients. METHODS: Studies comparing the outcomes following hip arthroscopy of obese and non-obese patients were systematically identified via a computer-assisted literature search of Pubmed (Medline), EMBASE, and Cochrane Library using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Studies comparing the outcome of hip arthroscopy in different body mass index (BMI) groups were included. Data including patient-reported outcome measures (PROMs), revision arthroscopy rate, conversion rate to total hip arthroplasty (THA), and complications were collected. The methodological index for non-randomized studies (MINORS) and Newcastle-Ottawa Scale (NOS) were used to assess the quality of each study quality. The effect of heterogeneity was quantified by calculating the I2 value. RESULTS: A total of eight studies were finally included in the qualitative analysis, and three studies of high quality involving 373 hips were included in the quantitative assessment. All the studies defined obesity as a BMI of ≥ 30 kg/m2. The modified Harris Hip Score and the Non-Arthritic Hip Score were 5.1 (95% CI 1.1-9.1) and 9.0 (95% CI 5.0-13.1) points lower, respectively, in the obese group than in the non-obese group. The pooled odds ratios were 1.2 (95% CI 0.5-2.7) for revision arthroscopy, 2.4 (95% CI 1.3-4.6) for conversion to THA, and 3.2 (95% CI 1.2-8.6 for complications in favor of the non-obese group. The heterogeneity was low in all outcome assessments (I2 0-18%). CONCLUSION: Obese patients had significantly lower PROMs than non-obese patients following hip arthroscopic surgery, and the THA conversion and complication rates were 2.4 times and 3.2 times higher, respectively. Understanding the effect of obesity on hip arthroscopy will allow appropriate surgical indications for surgery to be further refined and help obese patients to understand their individual risk profile. LEVEL OF EVIDENCE: Systematic review of Level III-IV studies, Level IV.2021年05月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(5) (5), 1483 - 1493, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Rich vascularity of the induced membrane (IM) is important for Masquelet reconstruction surgery. The factors affecting IM vascularity are not completely understood. This study aimed to investigate these factors using histological samples of human IMs. METHODS: We retrospectively evaluated 36 patients whose bone defects were treated using the Masquelet technique. Two clinical pathologists analyzed histological sections of IM pieces (1 cm2). The number of blood vessels per 1 mm2 was counted and compared among men and women, femur or tibia, with and without free flap surgery, antibiotic impregnation to the cement, osteogenesis inside the membrane, smoking, and diabetes mellitus. The number of blood vessels within the same patient was compared among different time points. Correlation analysis was performed among blood vessel numbers and patient age, duration of cement spacer placement, and histological grading scales (inflammation, foreign body reaction, and fibrosis). RESULTS: IM formation with rich vascularity and some inflammation, foreign body reaction, and fibrosis were histologically confirmed in all patients. We found 37.4 ± 19.1 blood vessels per 1 mm2. The number of blood vessels was significantly lower in patients with than in those without free flap surgery; it was higher in patients with osteogenesis inside the IM. No significant correlations were found in any of the analyses. CONCLUSION: Sex, patient age, smoking, diabetes mellitus, femur or tibia, duration of cement spacer placement, and antibiotic impregnation to the cement did not affect IM vascularization. IM vascularization was reduced in patients with than in those without free flap surgery.2021年04月, Journal of orthopaedic surgery and research, 16(1) (1), 248 - 248, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Tibial plateau fractures are serious complications of Oxford mobile-bearing unicompartmental knee arthroplasty (OUKA). This study examined where the fracture lines arises and evaluated the keel-cortex distances (KCDs) using three-dimensional computed tomography (3D-CT) and the effects of technical error (assessed by tibial component positions) and proximal tibial morphology on the KCDs. METHODS: This retrospective study included 217 OUKAs with cementless tibial components. Fifteen patients had tibial fractures after surgery. Anterior and posterior KCDs and fracture line origins were assessed using 3D-CT postoperatively. Proximal tibial morphology was assessed using the medial eminence line (MEL), which runs parallel to the tibial axis and passes through the tip of the medial intercondylar eminence of the tibia on long-leg anteroposterior radiograph. Knees had overhanging medial tibial condyle if the MEL passed medially to the medial tibial cortex. KCDs were compared between patients with/without fractures. Tibial component positions were evaluated, considering effects of tibial morphologies and component positions on fracture prevalence and KCDs. RESULTS: Fracture lines were found between the keel and posterior cortex in 12/15 patients. Posterior KCDs were significantly shorter in patients with fractures than in patients without (2.7 ± 1.6 mm vs 5.2 ± 1.7 mm, P < 0.001). Patients with medial overhanging condyles were more likely to have fracture (10/51 vs 5/166, P < 0.001) and had significantly shorter posterior KCD than those without (3.6 ± 1.5 mm vs 5.5 ± 1.8 mm, P < 0.001). Patients with tibial component that was set too medial, low, and valgus had higher rates of fracture than those without (7/39 vs 8/178, P = 0.008). Medial (r = 0.30, P < 0.001), low (r = -0.33, P < 0.001), and valgus implantations (r = 0.35, P < 0.001) of tibial components were related to shorter posterior KCDs. CONCLUSION: Short posterior KCD after OUKA is a risk factor for postoperative tibial fracture. Patients with either malposition of the tibial component (too medial, low, and valgus) and/or a medial overhanging condyle exhibit a shorter distance of posterior KCD and higher rate of fracture. LEVEL OF EVIDENCE: Level III.2021年04月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 30(4) (4), 1220 - 1230, 英語, 国際誌研究論文（学術雑誌）
- This study aimed to investigate the accuracy of cup placement and determine the predictive risk factors for inaccurate cup positioning in robot-assisted total hip arthroplasty (THA). We retrospectively analyzed 115 patients who underwent robot-assisted THA between August 2018 and November 2019. Acetabular cup alignment and three-dimensional (3D) position were measured using pre- or postoperative computed tomography (CT) data. Absolute differences in cup inclination, anteversion, and 3D position were assessed, and their relation to preoperative factors was evaluated. The average measurement of the absolute differences was 1.8° ± 2.0° (inclination) and 1.9° ± 2.3° (anteversion). The average absolute difference in the 3D cup position was 1.1 ± 1.2 mm (coronal plane) and 0.9 ± 1.0 mm (axial plane). Multivariate analysis revealed that a posterior pelvic tilt [odds ratio (OR, 1.1; 95% confidence interval (CI), 1.00-1.23] and anterior surgical approach (OR, 5.1; 95% CI, 1.69-15.38) were predictive factors for inaccurate cup positioning with robot-assisted THA. This is the first study to demonstrate the predictive risk factors (posterior pelvic tilt and anterior surgical approach) for inaccurate cup position in robot-assisted THA.2021年04月, Scientific reports, 11(1) (1), 7578 - 7578, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: This study compared the early clinical recovery of total hip arthroplasty (THA) using computer navigation systems (nTHA) and robotic arm-assisted THA (rTHA). METHODS: Thirty prospective subjects who underwent rTHA were clinically compared to 30 subjects who underwent nTHA. Clinical data (surgical time, intraoperative blood loss, pain severity, number of days to independent walking, and Harris Hip Score (HHS) at discharge), and radiographic parameters (inclination and anteversion angles) were statistically compared between the two groups. RESULTS: Follow-up times were 24.3 ± 6.0 and 27.0 ± 7.0 days in the rTHA and nTHA groups, respectively. The surgical time (135.1 ± 13.9 min vs. 146.2 ± 12.8 min, p = 0.002), number of days to independent walking (7.2 ± 2.0 vs. 11.5 ± 3.0 days, p < 0.001), and postoperative pain using a numeric rating scale on postoperative days 7, 10,, and 14 (1.4 ± 0.9 vs. 2.2 ± 1.2, p = 0.005; 1.0 ± 0.8 vs. 1.8 ± 1.1, p = 0.002; 0.3 ± 0.5 vs. 1.1 ± 0.9, p < 0.001; respectively) were significantly reduced in the rTHA group compared to the nTHA group. The rTHA group showed a significantly higher postoperative HHS compared to the nTHA group (85.3 ± .3.2 vs. 81.0 ± 8.5, p = 0.014). No statistically significant difference was observed in radiographic parameters between the groups; however, the incidence of intraoperative target angle changes was significantly lower in the rTHA group than in the nTHA group (0/30 subjects [0%] vs. 11/30 subjects [36.7%], p < 0.001). CONCLUSION: The surgical time, postoperative pain, and number of days to independent walking were significantly shorter, and the HHS at discharge was significantly higher in the rTHA group than in the nTHA group. Thus, compared to the nTHA group, the rTHA group showed improved early clinical recovery.2021年03月, BMC musculoskeletal disorders, 22(1) (1), 314 - 314, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2021年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 65回, 701 - 701, 日本語生物学的製剤を使用中の関節リウマチ患者における単純ヘルペスおよび帯状疱疹ヘルペスの発症リスクを予測する新規バイオマーカーの同定
- Rheumatoid arthritis (RA) is a common chronic autoimmune disease leading to joint destruction. The aim of the present study was to identify the genomic factors predictive of susceptibility to joint destruction in patients with RA by performing a genome-wide association study of genetic variants, including single nucleotide polymorphisms (SNPs). The study sample included 228 patients with a diagnosis of RA in the past 5 years. Patients were classified into rapid (total Sharp score/years of RA, ≥50) and slow (total Sharp score/years of RA, <50) joint destruction groups for analysis. The association between the genome-wide SNP analysis and joint destruction was evaluated. The following SNPs were strongly associated with rapid radiographic joint destruction: rs2295926 (P<1x10-7), belonging to the N-acetylgalactosaminyltransferase 12 (GALNT12) gene and rs11958855 (P<1x10-6), belonging to the KCNN2 gene (associated with the potassium calcium-activated channel subfamily). The identification of genetic predictors of rapid joint destruction in RA (GALNT12 and KCNN2) may provide information regarding potential therapeutic targets, and this information may be used to assist in the management RA disease progression, thereby improving the functional outcomes for patients.2021年03月, Biomedical reports, 14(3) (3), 31 - 31, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Novel therapeutic strategies for the healing of nonunion, which has serious effects on the quality of life of patients, are needed. We evaluated the therapeutic effect of local transplantation of human stromal vascular fraction (SVF) cells on fracture healing in a rat non-healing fracture model and compared the effects between freshly isolated (F) and cryopreserved (C)-SVFs. METHODS: Non-healing fracture model was induced in the femur of female immunodeficient rats (F344/N Jcl rnu/rnu) with cauterizing periosteum. Immediately after the creation of non-healing fracture, rats received local transplantation of F and C-SVFs suspended in phosphate-buffered saline (PBS) or the same volume of PBS without cells using the same scaffold as a control group. During 8 weeks post-surgery, radiologic, histological, immunohistochemical, and biomechanical analyses were performed to evaluate fracture healing. The comparison of radiological results was performed with a chi-square test, and the multiple comparisons of immunohistochemical, histological, and biomechanical results among groups were made using a one-way analysis of variance. A probability value of 0.05 was considered to denote statistical significance. RESULTS: At week 8, in 60% of animals receiving F-SVF cells and in 50% of animals receiving C-SVF cells, the fracture radiologically healed with bone union whereas nonunion was observed in the control group. The healing potential was also confirmed by histological and biomechanical assessments. One of the mechanisms underlying healing involving intrinsic angiogenesis/osteogenesis was enhanced in F- and C-SVF groups compared with that in the control group. Human cell-derived vasculogenesis/osteogenesis, which was also confirmed in an in vitro differentiation assay, was also enhanced in the F- and C-SVF groups compared with that in the control groups and could be another mechanism for healing. CONCLUSIONS: SVF cells can enhance bone healing and cryopreserved cells have almost equal potential as fresh cells. SVF cells can be used for improving nonunion bone fracture healing as an alternative to other mesenchymal stem cells and the effect of SVF cells can be maintained under cryopreservation.2021年02月, Stem cell research & therapy, 12(1) (1), 110 - 110, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to compare the intraoperative kinematics, especially for mid-flexion femorotibial anteroposterior (AP) stability, between newly developed medial congruent (MC) inserts and cruciate-retaining (CR) inserts in navigated cruciate-retaining total knee arthroplasty (CR-TKA). METHODS: Thirty consecutive patients with varus osteoarthritis undergoing CR-TKA using an image-free navigation system were enrolled. AP kinematics, the AP translation under manual maximum stress to the knee joint at 45° flexion, rotational kinematics, and varus-valgus laxity were evaluated using a navigation system and statistically compared between the MC and CR inserts. RESULTS: AP kinematic analysis showed that the femoral position with the CR insert was significantly anterior at a maximum extension to 45° flexion compared with the MC insert (p < 0.05). The amount of AP translation at 45° flexion with the MC insert was significantly smaller than that with the CR insert (p < 0.05). Rotational kinematics found that the tibial position at maximum extension was significantly externally rotated with the MC inserts than with the CR inserts. Varus-valgus laxity was comparable between the MC and CR inserts. CONCLUSION: The current results showed that greater mid-flexion AP stability was achieved with the MC inserts than with the CR inserts in CR-TKA. Intraoperative kinematics with the MC inserts more closely resembled those with preoperative conditions in CR-TKA. LEVEL OF EVIDENCE: III, prospective comparative study.2021年02月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29(2) (2), 467 - 473, 英語, 国際誌研究論文（学術雑誌）
- Background: The aim of this study was to investigate the use of pre-operative templating for bipolar hip arthroplasty (BHA) for displaced femoral neck fracture using multiplanar reconstruction (MPR) of computed tomography (CT) images. Methods: Nineteen patients who underwent BHA were enrolled in this study. For pre- and post-operative evaluation, a CT scan was performed from the pelvis to the knee joints. MPR of the CT image was done using software to measure the femoral head cup diameter, offset, stem size, length of the modular neck, distance from the neck osteotomy, and femoral anteversion. We compared these parameters pre- and post-operatively. Results: Both the femoral head cup diameter and length of the modular neck were found to be significantly different between pre- and post-operative measurements, although the differences were minor. Other parameters, including the femoral offset, were not significantly different between the pre- and post-operative measurements. The size of the femoral stem, cup diameter, and length of the modular neck were consistent with the planned size and accurate (within ±1 size) in more than 84% cases. Conclusion: Our pre-operative templating approach for BHA using MPR of CT has potential clinical utility as a complementary tool for pre-operative planning using three-dimensional templating software. Moreover, this technique could be feasible in most hospitals without additional expenditure.2021年02月, Journal of clinical orthopaedics and trauma, 13, 1 - 8, 英語, 国際誌研究論文（学術雑誌）
- Tumor-induced osteomalacia (TIO) is a rare skeletal disease caused by hypersecretion of fibroblast growth factor 23 (FGF-23) from neoplasms of mesenchymal origin; patients with TIO present with insufficiency fractures, progressive bone pain, and delayed fracture unions. Herein, we report the case of a 48-year-old man with an insufficiency fracture in his left femoral neck associated with TIO. The causative tumor located in the patient's maxillary sinus had been resected; however, complete resection was impossible due to the location of the tumor. Therefore, the patient's osteomalacia persisted, and he experienced a left femoral neck fracture in the absence of severe trauma. Because delayed fracture union was anticipated in this patient, we performed an internal fixation using an implant with a lateral plate for angular stability and multiple screws for rotational stability. Although fracture union took 15 months, the patient's postoperative course was uneventful, and he could walk without any symptoms or assistance at his most recent follow-up 30 months after surgery. In TIO, hypersecretion of FGF-23 leads to increased renal excretion of phosphorus, increased bone resorption of calcium and phosphorus, decreased osteoblastic bone mineralization, and decreased gastrointestinal absorption of calcium and phosphorus, leading to insufficiency fractures and delayed fracture unions. Diagnosis of TIO is often delayed due to its rarity and vague symptoms. Total resection of the causative tumor is the optimal treatment; however, in cases wherein complete tumor resection is impossible, drug therapy may be insufficient, and the underlying TIO pathology, including bone fragility, may persist. Early diagnosis of TIO is important for preventing insufficiency fractures; however, when fractures are unavoidable, the surgical treatment of femoral neck fractures in patients with osteomalacia should account for a longer time frame for complete fracture union and therefore utilize implants with sufficient stability.2021年, Case reports in orthopedics, 2021, 6668006 - 6668006, 英語, 国際誌
- Kinematically aligned total knee arthroplasty (TKA) has gained interest for achieving more favorable clinical outcomes than mechanically aligned TKA. The present study aimed to compare the clinical outcomes of kinematically aligned TKAs using single-radius (SR) or multi-radius (MR) prostheses. Sixty modified kinematically aligned cruciate-retaining TKAs (30 SR and 30 MR type prostheses) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative and postoperative patellar tracking were compared between the two groups. Trochlea shape was also compared between the prostheses and preoperative native anatomy using three-dimensional simulation software. Total 2 years postoperatively, the range of motion and 2011 Knee Society Scores (KSS) were compared between the two groups. There were no differences in patellar maltracking including patellar lateral shift and tilt between the two groups; however, the ratio of intraoperative lateral retinacular release for adjusting patellar tracking was significantly higher in the MR group than in the SR group. Lateral and medial facet heights in both prostheses were understuffed compared with native knee anatomy, while the deepest point of the trochlear groove was significantly more medial in the MR group. The postoperative clinical outcomes showed no significant differences between the two groups. In conclusion, modified kinematically aligned TKAs using a SR or MR prosthesis showed no significant differences in clinical outcomes or patellar tracking when appropriate lateral retinacular release was performed.2020年12月, The journal of knee surgery, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: This study aimed to examine the accuracy of the HipAlign® accelerometer-based portable navigation system by measuring the intraoperative leg length change of patients who underwent total hip arthroplasty (THA) and comparing the measured leg length discrepancy (LLD) determined by the navigation system and a freehand technique. METHODS: A total of 61 patients who underwent THA using the anterolateral approach in the supine position were included in this study and divided into two groups: those who underwent THA with navigation (Group N; N = 31) and with the freehand technique (Group F; N = 30). Statistical analyses were performed to compare the intraoperative leg length change, pre- and post-LLD, absolute values of post-LLD, and the number of patients with the postoperative LLD within 10 mm and 5 mm between the two groups. Additionally, we examined the correlation between the leg length change obtained through intraoperative navigation and measured from the radiographs. Moreover, to evaluate the navigation accuracy, we examined the correlation between the absolute error of leg length change and cup orientation. RESULTS: The postoperative LLD was significantly lower and the number of patients with the postoperative LLD within 5 mm was significantly higher in Group N, compared with Group F. Additionally, the amount of leg length change measured intraoperatively by the navigation system was strongly correlated with the values obtained by the postoperative radiographic measurement with a small absolute error and minimal wasted time. Moreover, a significant positive correlation was found between the absolute error of the leg length change and that of the cup inclination. CONCLUSIONS: Our study demonstrates that the accelerometer-based portable navigation system is useful for the intraoperative adjustment of leg length discrepancy during THA for patients in the supine position, as it provides good accuracy and minimizes required time for use.2020年12月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 27(1) (1), 169 - 175, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: The occurrence of thigh pain following cementless total hip arthroplasty (THA) may be dependent on multiple factors, which may differ with design of the prosthesis. Thus, this study aimed to investigate the frequency of thigh pain following cementless THA using a short, tapered-wedge stem to identify risk factors for thigh pain. METHODS: This retrospective cohort study analysed 222 joints of patients who underwent THA with a short, tapered-wedge stem. Thigh pain was evaluated using a questionnaire during each follow-up visit, and the clinical and radiographic assessments were compared. RESULTS: Thigh pain occurred in 37 patients (16.7%) during the follow-up period. The pain started two to 24 months after THA. Multivariate analysis demonstrated that higher University of California, Los Angeles, activity rating (odds ratio 7.2; 95% confidence interval (CI) 3.0-17.2); Dorr type C femoral bone shape (odds ratio 1.5; 95% CI 1.1-2.0); and stem tip-cortical bone contact (odds ratio 8.2; 95% CI 2.3-29.4) were significant risk factors of thigh pain following THA. Post-operatively, cortical hypertrophy at Gruen zone 4 was significantly found in patients with thigh pain (p value = 0.032). CONCLUSION: Risk factors of pain following THA with short, tapered-wedge stem were high activity level, Dorr type C femoral bone shape, and stem tip contacting the distal bone surface. Moreover, post-operative cortical hypertrophy at the distal stem tip significantly increased the incidence of thigh pain. Therefore, we must pay attention to the aforementioned factors to avoid post-operative thigh pain when using a short, tapered-wedge stem.2020年12月, International orthopaedics, 44(12) (12), 2553 - 2558, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The effect of increased tibial slope on the bearing movement and clinical results in mobile-bearing unicompartmental knee arthroplasty has not been well discussed. We aimed to clarify the extent of in vivo sagittal bearing movement and bearing overhang using fluoroscopy and their relationship with the tibial posterior slopes and clinical results. METHODS: This retrospective study included 40 patients who underwent Oxford unicompartmental knee arthroplasty for anteromedial osteoarthritis or osteonecrosis of the knee. Intraoperative posterior translation and posterior overhang of the bearing were assessed during flexion. The tibial posterior slopes were evaluated before and 2 weeks after surgery, and its increment was recorded. Clinical evaluations were also performed preoperatively and at 2 years postoperatively (maximum flexion angle, Oxford Knee Score). Single linear regression analysis was performed to assess the correlation between the tibial posterior slopes and the posterior translation and the posterior overhang and determine if these could affect the clinical outcomes. FINDINGS: The average posterior translation was 10.7 ± 4.3 mm, and posterior overhang of the mobile bearing was found in 35% of overall patients. They were associated with increased tibial slope as well as poorer improvement in Oxford Knee Score at 2 years postoperatively. INTERPRETATION: In Oxford unicompartmental knee arthroplasty, mobile bearing can probably move posteriorly beyond the posterior margin of the tibial component during flexion when the tibial posterior slope increases more than the original magnitude. Additionally, the posterior translation and posterior overhang closely correlated with the poorer improvement in Oxford Knee Score at 2 years postoperatively.2020年12月, Clinical biomechanics (Bristol, Avon), 80, 105148 - 105148, 英語, 国際誌研究論文（学術雑誌）
- INTRODUCTION: Diabetes mellitus (DM) negatively affects fracture repair by inhibiting endochondral ossification, chondrogenesis, callus formation, and angiogenesis. We previously reported that transcutaneous CO2 application accelerates fracture repair by promoting endochondral ossification and angiogenesis. The present study aimed to determine whether CO2 treatment would promote fracture repair in cases with type I DM. RESEARCH DESIGN AND METHODS: A closed femoral shaft fracture was induced in female rats with streptozotocin-induced type I DM. CO2 treatment was performed five times a week for the CO2 group. Sham treatment, where CO2 was replaced with air, was performed for the control group. Radiographic, histologic, genetic, and biomechanical measurements were taken at several time points. RESULTS: Radiographic assessment demonstrated that fracture repair was induced in the CO2 group. Histologically, accelerated endochondral ossification and capillary formation were observed in the CO2 group. Immunohistochemical assessment indicated that early postfracture proliferation of chondrocytes in callus was enhanced in the CO2 group. Genetic assessment results suggested that cartilage and bone formation, angiogenesis, and vasodilation were upregulated in the CO2 group. Biomechanical assessment revealed enhanced mechanical strength in the CO2 group. CONCLUSIONS: Our findings suggest that CO2 treatment accelerates fracture repair in type I DM rats. CO2 treatment could be an effective strategy for delayed fracture repair due to DM.2020年12月, BMJ open diabetes research & care, 8(2) (2), 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: The direct relationship between clinical outcomes and femoral component positioning relative to a tibial insert remains unknown. We determined whether the femoral component position relative to the tibial insert could affect clinical outcomes after fixed-bearing unicompartmental knee arthroplasty (UKA). METHODS: The femoral component position relative to the tibial insert of 66 patients with anteromedial osteoarthritis and osteonecrosis of the knee who underwent fixed-bearing UKA was assessed at 2 weeks postoperatively. We classified patients according to the contact point of the femoral component with the tibial component: group M (medial), 18 knees; group C (central), 30 knees; and group L (lateral), 18 knees. Patient-derived clinical scores using the 2011 Knee Society Score were also assessed preoperatively and at 2 years postoperatively and compared among the 3 groups using the analysis of variance. RESULTS: The average 2-year postoperative "symptom" and "patient satisfaction" scores based on the 2011 Knee Society Score were significantly higher in group C than in group M or group L. CONCLUSION: Central implantation of the femoral component relative to the tibial insert plays an important role in decreasing pain and could result in better patient satisfaction after fixed-bearing UKA at 2 years postoperatively. Surgeons should set the femoral component at the center relative to the tibial insert for better patient satisfaction and higher active knee flexion after fixed-bearing UKA.2020年11月, The Journal of arthroplasty, 35(11) (11), 3108 - 3116, 英語, 国際誌研究論文（学術雑誌）
- The relationship between patellofemoral joint (PFJ) degeneration and clinical outcomes following lateral unicompartmental knee arthroplasty (UKA) has not been well described thus far. This study aimed to investigate the relationship between the preoperative PFJ condition and postoperative outcomes and the changes in lower-limb and PFJ alignment after lateral UKA. This was a retrospective study including 54 patients (mean age 72.9 years) who underwent lateral UKA for isolated lateral knee osteoarthritis at our institution between March 2013 and January 2019. The Oxford Knee Score (OKS), the Knee Society Score-Knee (KSSK), and Knee Society Score-Function (KSSF), the degree of degeneration, tilting angle and lateral shift of the PFJ, and the hip-knee-ankle angle (HKA) were evaluated pre- and postoperatively. The average follow-up period was 2.8 (range 1-6.1) years. There was a significant improvement in the OKS, KSSK, and KSSF after lateral UKA. Preoperative degeneration of the PFJ did not correlate with the recovery of clinical scores. The degeneration, tilting angle, and lateral shift of the PFJ did not significantly progress following lateral UKA. The HKA was improved after lateral UKA, and there was no correlation between the HKA change and PFJ condition. Postoperative severe valgus knee alignment was associated with a greater tilting angle. Preoperative degeneration of the PFJ did not have a negative impact on postoperative outcomes, and no short-term changes in the degeneration, tilting angle, and lateral shift of the PFJ were observed. Correction of knee-joint alignment did not have a negative impact on the condition of the PFJ.2020年10月, The journal of knee surgery, 35(7) (7), 810 - 815, 英語, 国際誌研究論文（学術雑誌）
- Treatment of rheumatoid arthritis (RA) is aimed at long-term remission and inhibition of joint destruction by different biologic drugs. However, the choice of a particular biologic agent based on individual cases of RA remains unestablished. Interleukin-6 (IL-6) inhibitor and tumor necrosis factor (TNF) inhibitor are common biologics used for the treatment of RA. This study aimed to investigate predictive factors for effective selection of tocilizumab (IL-6 inhibitor) and etanercept (TNF inhibitor) in patients with RA. This is a retrospective cohort study. The 196 patients analyzed in this study were divided into four groups: tocilizumab treatment as the first biologic group (TCZ first, 42 patients), tocilizumab as second/ third biologic group (TCZ second, 34 patients), etanercept as the first biologic group (ETN first, 103 patients) and etanercept as second/third group (ETN second, 17 patients). Visual analog scale (VAS), clinical disease activity index (CDAI), and modified health assessment questionnaire (mHAQ) scores at the initiation of biologic treatment and after 6 months of tocilizumab and etanercept therapy were measured and compared to clinical parameters and radiographical parameters among the four groups. CRP, MMP-3, VAS, CDAI, and HAQ were improved after 6 months of treatment in all groups. Improvement of clinical outcomes was correlated with CRP value, duration of RA, and Sharp scores at the initiation of treatment. Multivariate analysis demonstrated improvement in CDAI was significantly associated with the yearly progression of erosion according to the Sharp score in TCZ first group (OR, 1.5; 95% CI, 1.03-2.07) and was negatively associated with the duration of RA (OR, 0.49; 95% CI, 0.29-0.86) at the initiation of treatment with ETN first group. We identified the predictive factors for effective selection of tocilizumab and etanercept treatment and established the effectiveness of tocilizumab for the patients with rapid progressive joint erosion and etanercept for the early administration from diagnosis of RA.2020年10月, Scientific reports, 10(1) (1), 16645 - 16645, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The aim of this study was to examine and evaluate the factors associated with changes in limb alignment 10 years after total knee arthroplasty (TKA). The hypothesis was that bone morphology and immediate postoperative alignment could be correlated with long-term post-operative alignment changes following TKA. METHODS: This study retrospectively analysed 136 consecutive primary TKA cases for varus deformity, performed from 2006 to 2008, that could be followed for at least 10 years postoperatively. Anteroposterior long-leg weight-bearing radiographs were obtained within 1 month and at least 10 years after surgery. The hip-knee-ankle (HKA) angle immediately after surgery was compared with that 10 years later; factors correlating with the change in HKA angle (δHKA) were evaluated. RESULTS: The mean HKA angles were significantly different between immediate and long-term postoperative assessments (0.1° ± 1.9° vs. 1.2° ± 2.9°, p < 0.001). Furthermore, a significant difference was observed in the outlier ratio (> 3° deviation from the 0° of HKA angle) (10% vs. 24%, p = 0.002). δHKA strongly correlated with a higher preoperative tibial plateau tip-to-proximal tibial shaft (TPTPS) angle, higher postoperative HKA angle, lateral distal femoral angle, and lower postoperative medial proximal tibial angle. CONCLUSION: Varus deformity in the proximal part of the tibia, immediate postoperative varus alignment, and varus position of the femoral and tibial components may lead to varus progression in limb alignment in the long term, even 10 years after TKA; the surgeon should, therefore, weigh the risks of leaving a varus alignment during surgery. Moreover, if the preoperative TPTPS angle is high, the alignment may become varus after TKA, even in patients who have acquired neutral alignment. LEVEL OF EVIDENCE: IV.2020年10月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(10) (10), 3287 - 3293, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To evaluate the association of labral length with acetabular morphology and clinical symptoms. METHODS: Patients treated at our hip joint clinic between January 2015 and December 2018 were retrospectively enrolled in the study. Our sample included patients who received a diagnosis of one or more of the following: hip labral tear, femoroacetabular impingement (FAI), and developmental dysplasia of the hip. Patients with osteoarthritis and/or osteonecrosis were excluded. Bilateral labral length was measured as the distance from the acetabular rim to the edge of the labrum at the level of the central coronal T1-weighted magnetic resonance imaging scan cross-referenced to the axial plane (3- to 9-o'clock position). The lateral center-edge angle (LCEA) and acetabular roof obliquity (ARO) were evaluated with plain radiographs. An LCEA of 25° or less was defined as developmental dysplasia of the hip, whereas a positive crossover sign in the presence of an LCEA of 30° or greater, an LCEA greater than 40°, or acetabular inclination lower 0° was defined as pincer FAI. An alpha angle greater than 50° or head-neck offset lower 8 mm was considered cam FAI. The severity of hip symptoms was evaluated bilaterally using the Japanese Orthopaedic Association pain scale, on which hips scoring full points (i.e., a perfect score) were defined as asymptomatic whereas hips with all other scores were considered symptomatic. We used simple linear regression to examine the correlations of labral length with the LCEA and ARO. Labral length was also compared according to patient hip symptom status using the Mann-Whitney U test. RESULTS: The study included 102 patients (14 with bilateral symptoms and 88 with unilateral symptoms). Labral length was strongly correlated with the LCEA (r = -0.612, P < .001) and ARO (r = 0.635, P < .001). Additionally, patients with symptomatic hips had significantly larger labra (9.5 ± 3.0 mm) than those with asymptomatic hips (7.9 ± 2.1 mm, P = .004). CONCLUSIONS: Acetabular labral length is significantly greater in dysplastic, irregularly congruent, symptomatic hips. LEVEL OF EVIDENCE: Level Ⅳ, retrospective cross-sectional study.2020年09月, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 36(9) (9), 2446 - 2453, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: We hypothesized that preoperative pelvic morphology may affect postoperative anterior coverage and postoperative clinical range of motion (ROM) leading to postoperative pincer type femoroacetabular impingement (FAI). The aim of this study was to evaluate the relationships between preoperative bone morphology and postoperative ROMs to prevent postoperative FAI after periacetabular osteotomy. METHODS: Sixty-eight patients (71 hips) with hip dysplasia participated in this study and underwent curved PAO. The acetabular fragment was usually moved only by lateral rotation of the acetabulum, without intraoperative anterior or posterior rotation. The pre- and postoperative three-dimensional center-edge (CE) angles were measured and compared to the postoperative ROM. RESULTS: Preoperative medial anterior CE angle was significantly associated with postoperative anterior CE angle, and the correlation coefficient of medial anterior CE and postoperative anterior CE was higher than the coefficient of preoperative anterior CE and postoperative anterior CE (preoperative anterior CE, rr = 0.27, p = 0.020; preoperative medial anterior CE, rr = 0.54, p < 0.001). Femoral anteversion correlated with postoperative internal rotation angle at 90° flexion (r = 0.32, p = 0.021). In multiple linear regressions, postoperative internal rotation angle at 90° flexion angle was significantly affected by both medial CE angle through the medial one fourth of femoral head and femoral anteversion. CONCLUSIONS: Preoperative medial anterior acetabular coverage was associated with postoperative anterior acetabular coverage. Further, the combination with preoperative medial anterior acetabular coverage and femoral anteversion can predict postoperative internal rotation at 90° flexion. Therefore, the direction of acetabular reorientation should be carefully considered when the patients have high preoperative medial anterior CE angle and small femoral anteversion.2020年08月, Journal of orthopaedic surgery and research, 15(1) (1), 312 - 312, 英語, 国際誌研究論文（学術雑誌）
- BackgroundDistraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2therapy on distraction osteogenesis has been reported.Questions/purposesWe aimed to investigate the effect of transcutaneous CO2during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF)-1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy?MethodsForty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2on the operated leg using a CO2absorption-enhancing hydrogel was performed five times per week in the CO2group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus.ResultsRadiographs showed higher pixel values in the distracted area in the CO2group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm2[95% CI 1.26 to 2.92 mm2] versus 5.10 ± 3.91 mm2[95% CI 2.68 to 7.52 mm2]; p = 0.011). More newly formed bone was observed in the CO2group than the control group at Week 4 (68.31 ± 16.32 mm2[95% CI 58.19 to 78.44 mm2] versus 96.26 ± 19.37 mm2[95% CI 84.25 to 108.26 mm2]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55/mm2[95% CI 232.58 to 340.49] versus 410.24 ± 55.29/mm2[95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm2[95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm2[95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42/mm2[95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm2[95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP-2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2group than in the control group (BMP-2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP-7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92).ConclusionTranscutaneous application of CO2accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification.Clinical RelevanceThe use of the transcutaneous application of CO2may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2in the local tissue is required before it can be used in future clinical practice.2020年08月, Clinical Orthopaedics and Related Research, 478(8) (8), 1922 - 1935研究論文（学術雑誌）
- The aim of this study was to evaluate the relationship between the correction of radiographic parameters and clinical range of motion (ROM) after periacetabular osteotomy (PAO). Sixty-nine patients with hip dysplasia were enrolled and underwent curved PAO. The pre- and post-operative 3D center-edge (CE) angles, total anteversion (acetabular and femoral anteversion), and radiographic acetabular roof angle were measured and compared with the post-operative ROM. The aim of surgery was to rotate the central acetabular fragment laterally without anterior or posterior rotation. Multiple linear regression analysis demonstrated that post-operative internal rotation at 90° flexion was significantly associated with the post-operative Tönnis sourcil angle (rr = 0.31, P = 0.02) and that the post-operative ROM of flexion and internal rotation at 90° flexion were significantly associated with the anterior CE (flex; rr = -0.44, P = 0.001, internal rotation at 90° flexion; rr = -0.44, P < 0.001). However, we found no association between the lateral CE, femoral anteversion, or total anteversion and the post-operative ROM. We demonstrated that the overcorrection of the acetabular roof angle or anterior CE angle may cause a decrease in the range of motion after curved PAO. Therefore, surgeons need to be careful during surgery to prevent the overcorrection of the weight-bearing area and anterior acetabular coverage of the acetabular fragment to avoid femoroacetabular impingement after PAO.2020年08月, Journal of hip preservation surgery, 7(3) (3), 583 - 590, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Our previous studies of rats have reported that the transcutaneous application of CO2 accelerates fracture repair and bone-defect healing in rats by promoting angiogenesis, blood flow, and endochondral ossification. This therapy may also accelerate bone generation during distraction osteogenesis, but, to our knowledge, no study investigating CO2 therapy on distraction osteogenesis has been reported. QUESTIONS/PURPOSES: We aimed to investigate the effect of transcutaneous CO2 during distraction osteogenesis in rabbits, which are the most suitable animal as a distraction osteogenesis model for a lengthener in terms of limb size. We asked: Does transcutaneous CO2 during distraction osteogenesis alter (1) radiographic bone density in the distraction gap during healing; (2) callus parameters, including callus bone mineral content, volumetric bone mineral density, and bone volume fraction; (3) the newly formed bone area, cartilage area, and angiogenesis, as well as the expression of interleukin-6 (IL-6), BMP-2, BMP-7, hypoxia-inducible factor (HIF) -1α, and vascular endothelial growth factor (VEGF); and (4) three-point bend biomechanical strength, stiffness, and energy? METHODS: Forty 24-week-old female New Zealand white rabbits were used according to a research protocol approved by our institutional ethical committee. A distraction osteogenesis rabbit tibia model was created as previously described. Briefly, an external lengthener was applied to the right tibia, and a transverse osteotomy was performed at the mid-shaft. The osteotomy stumps were connected by adjusting the fixator to make no gap. After a 7-day latency phase, distraction was continued at 1 mm per day for 10 days. Beginning the day after the osteotomy, a 20-minute transcutaneous application of CO2 on the operated leg using a CO2 absorption-enhancing hydrogel was performed five times per week in the CO2 group (n = 20). Sham treatment with air was administered in the control group (n = 20). Animals were euthanized immediately after the distraction period (n = 10), 2 weeks (n = 10), and 4 weeks (n = 20) after completion of distraction. We performed bone density quantification on the plain radiographs to evaluate consolidation in the distraction gap with image analyzing software. Callus parameters were measured with micro-CT to assess callus microstructure. The newly formed bone area and cartilage area were measured histologically with safranin O/fast green staining to assess the progress of ossification. We also performed immunohistochemical staining of endothelial cells with fluorescein-labeled isolectin B4 and examined capillary density to evaluate angiogenesis. Gene expressions in newly generated callus were analyzed by real-time polymerase chain reaction. Biomechanical strength, stiffness, and energy were determined from a three-point bend test to assess the mechanical strength of the callus. RESULTS: Radiographs showed higher pixel values in the distracted area in the CO2 group than the control group at Week 4 of the consolidation phase (0.98 ± 0.11 [95% confidence interval 0.89 to 1.06] versus 1.19 ± 0.23 [95% CI 1.05 to 1.34]; p = 0.013). Micro-CT demonstrated that bone volume fraction in the CO2 group was higher than that in the control group at Week 4 (5.56 ± 3.21 % [95% CI 4.32 to 6.12 %] versus 11.90 ± 3.33 % [95% CI 9.63 to 14.25 %]; p = 0.035). There were no differences in any other parameters (that is, callus bone mineral content at Weeks 2 and 4; volumetric bone mineral density at Weeks 2 and 4; bone volume fraction at Week 2). At Week 2, rabbits in the CO2 group had a larger cartilage area compared with those in the control group (2.09 ± 1.34 mm [95% CI 1.26 to 2.92 mm] versus 5.10 ± 3.91 mm [95% CI 2.68 to 7.52 mm]; p = 0.011). More newly formed bone was observed in the CO2 group than the control group at Week 4 (68.31 ± 16.32 mm [95% CI 58.19 to 78.44 mm] versus 96.26 ± 19.37 mm [95% CI 84.25 to 108.26 mm]; p < 0.001). There were no differences in any other parameters (cartilage area at Weeks 0 and 4; newly formed bone area at Weeks 0 and 2). Immunohistochemical isolectin B4 staining showed greater capillary densities in rabbits in the CO2 group than the control group in the distraction area at Week 0 and surrounding tissue at Weeks 0 and 2 (distraction area at Week 0, 286.54 ± 61.55 /mm [95% CI 232.58 to 340.49] versus 410.24 ± 55.29 /mm [95% CI 361.78 to 458.71]; p < 0.001; surrounding tissue at Week 0 395.09 ± 68.16/mm [95% CI 335.34 to 454.83] versus 589.75 ± 174.42/mm [95% CI 436.86 to 742.64]; p = 0.003; at Week 2 271.22 ± 169.42 /mm [95% CI 122.71 to 419.73] versus 508.46 ± 49.06/mm [95% CI 465.45 to 551.47]; p < 0.001 respectively). There was no difference in the distraction area at Week 2. The expressions of BMP -2 at Week 2, HIF1-α at Week 2 and VEGF at Week 0 and 2 were greater in the CO2 group than in the control group (BMP -2 at Week 2 3.84 ± 0.83 fold [95% CI 3.11 to 4.58] versus 7.32 ± 1.63 fold [95% CI 5.88 to 8.75]; p < 0.001; HIF1-α at Week 2, 10.49 ± 2.93 fold [95% CI 7.91 to 13.06] versus 20.74 ± 11.01 fold [95% CI 11.09 to 30.40]; p < 0.001; VEGF at Week 0 4.80 ± 1.56 fold [95% CI 3.43 to 6.18] versus 11.36 ± 4.82 fold [95% CI 7.13 to 15.59]; p < 0.001; at Week 2 31.52 ± 8.26 fold [95% CI 24.27 to 38.76] versus 51.05 ± 15.52 fold [95% CI 37.44 to 64.66]; p = 0.034, respectively). There were no differences in any other parameters (BMP-2 at Week 0 and 4; BMP -7 at Weeks 0, 2 and 4; HIF-1α at Weeks 0 and 4; IL-6 at Weeks 0, 2 and 4; VEGF at Week 4). In the biomechanical assessment, ultimate stress and failure energy were greater in the CO2 group than in the control group at Week 4 (ultimate stress 259.96 ± 74.33 N [95% CI 167.66 to 352.25] versus 422.45 ± 99.32 N [95% CI 299.13 to 545.77]; p < 0.001, failure energy 311.32 ± 99.01 Nmm [95% CI 188.37 to 434.25] versus 954.97 ± 484.39 Nmm [95% CI 353.51 to 1556.42]; p = 0.003, respectively). There was no difference in stiffness (216.77 ± 143.39 N/mm [95% CI 38.73 to 394.81] versus 223.68 ± 122.17 N/mm [95% CI 71.99 to 375.37]; p = 0.92). CONCLUSION: Transcutaneous application of CO2 accelerated bone generation in a distraction osteogenesis model of rabbit tibias. As demonstrated in previous studies, CO2 treatment might affect bone regeneration in distraction osteogenesis by promoting angiogenesis, blood flow, and endochondral ossification. CLINICAL RELEVANCE: The use of the transcutaneous application of CO2 may open new possibilities for shortening healing time in patients with distraction osteogenesis. However, a deeper insight into the mechanism of CO2 in the local tissue is required before it can be used in future clinical practice.2020年08月, Clinical orthopaedics and related research, 478(8) (8), 1922 - 1935, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVES: Synovial fluids of rheumatoid arthritis (RA) patients commonly contain high concentrations of soluble CD14 (sCD14). To investigate its potential role in RA pathogenesis, we tested whether sCD14 binding transmits a signal to fibroblast-like synoviocytes from RA patients (RA-FLS). METHODS: The induction of pro-inflammatory cytokines, chemokines, and mediators by sCD14 stimulation of RA-FLS was quantified by real-time PCR and ELISA. Cell proliferation was assessed by the BrdU assay. LPS-RS, a Toll-like receptor 4 (TLR-4) antagonist, was used to block TLR-4 signaling. RESULTS: Soluble CD14 induced the expression of IL-6 mRNA and secretion of the protein. The expression of other pro-inflammatory cytokines and mediators, such as TNF-α, IL-8, intercellular adhesion molecule-1 (ICAM-1), MMP-3, and RANK ligand (RANKL), was also induced by sCD14. In addition, sCD14 stimulation promoted RA-FLS proliferation. LPS-RS abolished IL-6, IL-8, and ICAM-1 mRNA induction by sCD14 in RA-FLS. On the other hand, TNF-α and IL-17A increased TLR-4 expression by RA-FLS and amplified their sCD14-induced IL-6 expression. CONCLUSIONS: Soluble CD14 transmits inflammatory signals to RA-FLS via TLR-4. The effects of sCD14 may be augmented in inflammatory milieu. Our results suggest that sCD14 is involved in the pathogenesis of RA and may be a novel therapeutic target.2020年07月, Cells, 9(7) (7), 英語, 国際誌研究論文（学術雑誌）
- Background: Few studies have investigated the relationships between preoperative or intraoperative patient factors and postoperative quality of life (QOL) after revision total hip arthroplasty (THA). The aim of our study was to identify the predictors of QOL after revision THA for aseptic loosening. Materials and Methods: Fifty-one patients who underwent revision THA for aseptic loosening were included in the present study. Preoperative hip function was evaluated using the Japanese Orthopaedic Association (JOA) score. The patients' QOL after surgery was evaluated with EuroQol 5D (EQ-5D) assessment at the end of the 2-year follow-up. The patients were then divided into two groups: good QOL (score ≥ 0.6) and poor QOL (score < 0.6). Predictive factors (i.e., age, BMI, preoperative JOA score, and the degree of acetabular bone defect according to the Paprosky classification) were compared between both QOL groups. Furthermore, multiple linear regression was performed to assess independent factors affecting the QOL. Results: Significant differences between the good and poor QOL groups were identified for BMI, walking ability, and severity of acetabular bone defect (BMI: 21.5 ± 2.9 vs. 24.1 ± 4.3, P = 0.0331; walking ability: 11.5 ± 5.0 vs. 5.5 ± 4.9, P = 0.0058; acetabular bone defect: 44.4% vs. 81.0%, P = 0.0103). The walking ability independently affected the EQ-5D utility score. Conclusions: The present study indicates that a higher BMI, lower walking ability, and more severe acetabular bone defect are predictors of lower QOL after revision THA for aseptic loosening. In particular, the walking ability was the only independent factor. Thus, surgeons should pay attention to the postoperative management of patients with these risk factors.2020年07月, Indian journal of orthopaedics, 54(4) (4), 463 - 468, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: This study aimed to compare tibial rotation and patellar contact force between mobile- and fixed-bearing total knee arthroplasty from extension to flexion by using a navigation system and patellar contact force sensor on the same patients' knees. METHODS: Thirty-one consecutive patients who had undergone a primary posterior stabilized total knee arthroplasty were included. Patellar contact forces on the medial and lateral sides were measured at each flexion angle, and tibial rotation was assessed during 30-90°, and 90-120° knee flexion. The patellar contact force and tibial rotation were measured twice with the mobile- and fixed-platform trial components and compared between the two groups. FINDINGS: The patellar contact force was significantly lower with mobile than with fixed-bearing total knee arthroplasty on the medial side at 120° flexion (P = .0138) and lateral side at 60°, 90°, and 120° flexion (P = .0346, P = .0127, and P = .0376). There were no significant differences in tibial rotation between the mobile- and fixed-bearing inserts during both 30-90° and 90-120° knee flexion. INTERPRETATION: Patellar contact force was significantly lower, especially on the lateral side in mobile than in fixed-bearing total knee arthroplasty, whereas no significant difference in tibial internal rotation was found between the two inserts. Mobile-bearing inserts might reduce the patellar contact force by the bearing rotation, rather than natural tibial rotation during posterior stabilized total knee arthroplasty.2020年06月, Clinical biomechanics (Bristol, Avon), 76, 105022 - 105022, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: This study investigated whether the preoperative response to intra-articular injections is associated with intra-articular pathological findings and arthroscopy outcomes. METHODS: This study included 49 patients who underwent arthroscopic hip surgery for femoroacetabular impingement and labral tear after receiving preoperative hip joint injections. The response to anaesthetic injections was categorized as poor (0-50%) or good (51-100%). With respect to anatomical indices, we evaluated the lateral centre-edge angle (LCEA), acetabular roof obliquity (ARO), vertical-centre-anterior angle (VCA), and the alpha angle (on a lateral view). We evaluated the association between these indices (including the types of hip labral tears and cartilage damage) and the effectiveness of intra-articular injections. RESULTS: The study included 22 men and 27 women, and the mean age of patients was 36.4 years. No statistically significant association was observed between the response to preoperative anaesthetic hip joint injections and patient demographics (age, sex) and anatomical indices (LCEA, ARO, VCA, and alpha angle) (p > 0.05). All patients showed labral damage; however, labral tear classification or cartilage damage was not significantly associated with the effectiveness of joint injections. At the 1-year post-operative follow-up, patients with a good response to anaesthetic hip joint injections showed a significantly better outcome than patients with a poor response to these injections (p < 0.01). CONCLUSION: The response to preoperative anaesthetic hip joint injections may indicate the presence of intra-articular pathology. Furthermore, this association may have predictive value in determining post-operative outcomes following hip arthroscopy.2020年05月, European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 30(4) (4), 737 - 742, 英語, 国際誌研究論文（学術雑誌）
- Articular cartilage tissue has a poor healing potential, and when subjected to traumatic damage this tissue undergoes cartilage degeneration and osteoarthritis. The association between the regulation of cell cycle checkpoints and tissue regeneration has been previously investigated, and p21 was initially identified as a potent inhibitor of cell cycle progression. However, the effects of p21 defects on damaged tissue remain controversial. Therefore, the aim of the present study was to evaluate the effects of p21 deficiency on cartilage repair. A mouse model of articular cartilage repair was generated by inducing a patellar groove scratch in 8‑week‑old p21‑knockout (KO) mice and C57Bl/6 wild‑type (WT) mice. Mice were sacrificed at 4 and 8 weeks post‑surgery. The present study also investigated the effect of p21 deficiency on cartilage differentiation in ATDC5 cells in vitro. Safranin O staining results indicated that cartilage repair initially occurred in p21 KO mice. In addition, immunohistochemical analysis demonstrated that p21 KO upregulated proliferating cell nuclear antigen and increased cell proliferation. However, type II collagen and Sox9 expression levels remained unchanged in p21 KO and WT mice. Moreover, it was identified that p21 downregulation did not affect Sox9 and type II collagen expression levels in vitro. Furthermore, p21 deficiency promoted healing of articular cartilage damage, which was associated with cell proliferation in vivo, and increased chondrocyte proliferation but not differentiation in vitro. Therefore, the present results suggested that p21 does not affect Sox9 or type II collagen expression levels during cartilage differentiation in the repair of cartilage defects.2020年05月, Molecular medicine reports, 21(5) (5), 2236 - 2242, 英語, 国際誌研究論文（学術雑誌）
- Eicosapentanoic acid (EPA) is an antioxidant and omega-3 polyunsaturated fatty acid that reduces inflammatory cytokine production. Gelatin hydrogel can be used as a carrier of a physiologically active substance that release it gradually for an average of ~3 weeks. Therefore, this study aimed to clarify the effect of EPA-incorporating gelatin hydrogels on osteoarthritis (OA) progression in vivo. Ten-week-old male C57BL/6J mice were randomly divided into six groups (n = 6): Sham, destabilization of the medial meniscus (DMM), Corn: DMM + 2 µL corn oil, EPA injection alone (EPA-I): DMM + 2 µL corn oil + 125 μg/μL EPA, Gel: DMM + gelatin hydrogels, and EPA-G: DMM + 125 μg/μL EPA-incorporating gelatin hydrogels. The mice were euthanized at 8 weeks after DMM or Sham surgery, and subjected to histological evaluation. Matrix-metalloproteinases-3 (MMP-3), MMP-13, interleukin-1β (IL-1β), p-IKK α/β, CD86, and CD163 protein expression in the synovial cartilage was detected by immunohistochemical staining. F4/80 expression was also assessed using the F4/80 score of macrophage. Histological score was significantly lower in EPA-G than in EPA-I. MMP-3-, MMP-13-, IL-1β-, and p-IKK α/β-positive cell ratio was significantly lower in EPA-G than in EPA-I. However, CD86- and CD163-positive cell ratio was not significantly different between EPA-I and EPA-G. The average-sum F4/80 score of macrophage in EPA-G was significantly lower than that in EPA-I. EPA-incorporating gelatin hydrogels were shown to prevent OA progression in vivo more effectively than EPA injection alone. Our results suggested that intra-articular administration of controlled-release EPA can be a new therapeutic approach for treating OA.2020年04月, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(10) (10), 2157 - 2169, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Total hip arthroplasty (THA) is a useful treatment for pain relief and functional improvement. THA indications now include younger, more active patients, with improved implant design and bearing materials. We aimed to investigate daily activity level and return to work after THA, about which limited information is available. Moreover, differences in patient background and clinical parameters including size of femoral head and surgical approach were evaluated. METHODS: A multicentre survey was carried out in patients below 60 years, undergoing THA between 2007 and 2012, at least 1 year after surgery. Primary THA patients with osteoarthritis, avascular necrosis, rheumatoid arthritis, hip dysplasia, and no history of postoperative complications were included. The questionnaire included daily activity and occupation levels before and after surgery. University of California, Los Angeles (UCLA) activity score and occupational classification index were defined, and statistical analysis was performed. RESULTS: The mean preoperative UCLA score in 204 patients was 4.55 which improved to 6.17 after surgery. Pre- as well as postoperative UCLA scores in males were significantly higher than that in females. No differences were observed in other parameters. Return to work rate in males was 94.4%; significantly higher than that in females (52.3%). Younger patients with large head THA were more likely to return to work. CONCLUSIONS: Most patients showed improved activity levels. Satisfaction levels were higher in young males with large femoral head size. Patients with a higher preoperative work level are expected to have a higher return to work rate.2020年03月, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020911911 - 1120700020911911, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: The aim of this study was to evaluate the relationship between acetabular 3-dimensional (3D) alignment reorientation and clinical range of motion (ROM) after periacetabular osteotomy (PAO). METHODS: 50 patients (58 hips) with hip dysplasia participated in the study and underwent curved PAO. The pre- and postoperative 3D centre-edge (CE) angles and femoral anteversion were measured and compared with clinical outcomes, including postoperative ROM. RESULTS: The correlation between pre- and postoperative acetabular coverage and postoperative ROM was evaluated. Postoperative abduction and internal rotation ROM were significantly associated with postoperative lateral CE angles (abduction; p < 0.001, internal rotation; p = 0.028); flexion and internal rotation ROM was significantly associated with postoperative anterior CE angles (flexion; p < 0.001, internal rotation; p = 0.028). Femoral anteversion was negatively correlated with postoperative abduction (p = 0.017) and external rotation (p = 0.047) ROM. CONCLUSION: Postoperative anterior acetabular coverage may affect internal rotation ROM more than the lateral coverage. Therefore, the direction of acetabular reorientation should be carefully determined according to 3D alignment during PAO.2020年03月, Hip international : the journal of clinical and experimental research on hip pathology and therapy, 31(5) (5), 1120700020910370 - 1120700020910370, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本整形外科学会, 2020年03月, 日本整形外科学会雑誌, 94(3) (3), S1089 - S1089, 日本語
- (公社)日本整形外科学会, 2020年03月, 日本整形外科学会雑誌, 94(3) (3), S1089 - S1089, 日本語特発性大腿骨頭壊死症に対するTHA・大腿骨骨切り術における経時的QOL調査[査読有り]
- A 14-year-old girl experienced acute left buttock pain during a sprint. At the local hospital, she was diagnosed with an avulsion fracture of the left ischial tuberosity. She was kept for observation for about 10 months; however, the buttock pain persisted, and the bone fragments did not unite. She was referred to our hospital approximately 11 months after the injury. Plain radiography revealed an increased transposition of the bone fragment, from 12 mm immediately after the injury to 23 mm. Twelve months after the injury, she underwent osteosynthesis using two cannulated cancellous screws and three suture anchors. Following postoperative rehabilitation, the power in her left hamstring recovered, and she was able to run at full speed and returned to athletics 9 months after the surgery. The operative indications for avulsion fractures of the ischial tuberosity are unclear. Careful follow-up is required as the rate of nonunion after conservative treatment tends to be high. This needs to be identified in order to provide timely treatment that allows for early return to sport. Although she had significant chronic pain and muscle weakness, the surgery successfully treated the fracture, and her muscle power recovered, leading to her return to sports.2020年, Case reports in orthopedics, 2020, 8531648 - 8531648, 英語, 国際誌
- INTRODUCTION: Surgical site infection is one of the most severe complications of surgical treatments. However, the optimal procedure to prevent such infections remains uninvestigated. Ultraviolet radiation C (UVC) with a short wavelength has a high bactericidal effect; however, it is cytotoxic. Nonetheless, given that UVC with a wavelength of 222 nm reaches only the stratum corneum, it does not affect the skin cells. This study aimed to investigate the safety of 222-nm UVC irradiation and to examine its skin sterilization effect in healthy volunteers. METHODS: This trial was conducted on 20 healthy volunteers. The back of the subject was irradiated with 222-nm UVC at 50-500 mJ/cm2, and the induced erythema (redness of skin) was evaluated. Subsequently, the back was irradiated with a maximum amount of UVC not causing erythema, and the skin swabs before and after the irradiation were cultured. The number of colonies formed after 24 hours was measured. In addition, cyclobutene pyrimidine dimer (CPD) as an indicator of DNA damage was measured using skin tissues of the nonirradiated and irradiated regions. RESULTS: All subjects experienced no erythema at all doses. The back of the subject was irradiated at 500 mJ/cm2, and the number of bacterial colonies in the skin swab culture was significantly decreased by 222-nm UVC irradiation. The CPD amount produced in the irradiated region was slightly but significantly higher than that of the non-irradiated region. CONCLUSION: A 222-nm UVC at 500 mJ/cm2 was a safe irradiation dose and possessed bactericidal effects. In the future, 222-nm UVC irradiation is expected to contribute to the prevention of perioperative infection.2020年, PloS one, 15(8) (8), e0235948, 英語, 国際誌研究論文（学術雑誌）
- Curved periacetabular osteotomy (CPO) is used for the treatment of dysplastic hips. Previous studies have reported satisfying outcomes and low rate of severe complications associated with this procedure; however, no case of postoperative sciatic nerve palsy has been reported. In this study, we describe a case of postoperative sciatic nerve palsy following CPO due to nerve strangulation by scar tissue without direct injury. A female patient had severe buttock pain and posterior leg numbness after she underwent left-side CPO. Postoperative magnetic resonance imaging showed that the sciatic nerve was strangulated by the surrounding soft tissue. There was no bone fragment, active infection, bone necrosis, tumor, or spine disease. Therefore, we diagnosed nerve palsy by soft tissue strangulation, and revision surgery was indicated. During revision surgery, the sciatic nerve was observed to be strangulated by the scarring soft tissue, and the nerve had no mobility. After detachment, the pain and numbness disappeared. Direct injury of the sciatic nerve should not be caused by CPO; however, there is a possibility of postoperative sciatic nerve palsy due to the scarring soft tissue. Early diagnosis and appropriate treatment are important for optimal postoperative clinical outcomes.2020年, Case reports in orthopedics, 2020, 8569285 - 8569285, 英語, 国際誌
- Several studies have reported better clinical outcomes following kinematically aligned total knee arthroplasty (KA-TKA) than mechanically aligned TKA. Consistent reproduction of a KA-TKA is aided by accurate tibial bone resections using computer navigation systems. This study compares an accelerometer-based portable navigation system with a conventional navigation system on tibial bone resection and clinical outcomes in KA-TKA. This study included 60 knees of patients who underwent primary KA-TKA between May 2015 and September 2017. They were randomly assigned to the OrthoPilot and iASSIST groups. A tibial bone cut was performed with 3 degree varus and 7 degree posterior slope in relation to the mechanical axis in all cases. The tibial component angle (TCA) and posterior slope angle (PSA) were evaluated by postoperative radiography, and those that deviated more than 2 degree were set as outliers. The clinical outcomes were the knee range of motion (ROM) and 2011 Knee Society Score (KSS) evaluated at 1 year postoperation. The groups were compared in terms of the TCA, PSA, number of outliers, ROM, and 2011 KSS (p < 0.05). No significant difference was observed between the groups in terms of the mean TCA, PSA, number of outliers, ROM, and categories of the 2011 KSS (objective knee indicators, symptoms, satisfaction, expectations, and functional activities). Although tibial bone cuts were performed with 3 degree varus and 7 degree posterior slope, no significant difference was observed between the OrthoPilot and iASSIST groups in terms of the accuracy of cuts or postoperative clinical result. The iASSIST was found to be a simple and useful navigation system for KA-TKA.2019年12月, The journal of knee surgery, 34(8) (8), 870 - 876, 英語, 国際誌研究論文（学術雑誌）
- Since a hindfoot alignment is not included in the conventional mechanical axis (hip-ankle [HA] line), a mechanical axis including the calcaneus (hip-calcaneus [HC] line) has recently attracted attention as an alternative weight-bearing line. However, there are few reports on unicompartmental knee arthroplasty (UKA) regarding the HC line. Therefore, this study aimed to compare postoperative alignments after UKA between the HA line and the HC line. Postoperatively, HC radiographs were taken in 88 consecutive patients who underwent medial UKA. The hip-knee-ankle (HKA) and hip-knee-calcaneus (HKC) angles were compared in the same patient. Regarding tibial inclination, the conventional tibial component-ankle (TCA) angle was compared with reference to the HC line (tibial component-calcaneus [TCC] angle). The mean postoperative HKA and HKC angles were 2.8 ± 2.7 and 2.0 ± 2.5 degree, respectively. The mean postoperative TCA and TCC angles were 87.7 ± 2.1 and 88.5 ± 2.1 degree, respectively. There were significant differences between the two groups in both lower limb alignment and tibial component angle. The present study indicated that the HKC and the TCC angles significantly decreased the varus alignment by approximately 1 degree compared with the HKA and TCA angles. Neutral in the HA line corresponds to valgus in reference to the HC line, which may result in overcorrection. Surgeons should consider evaluating the HC line in place of the HA line, which may affect preoperative planning and postoperative outcome during UKA. This is a Level II, diagnostic study.2019年12月, The journal of knee surgery, 34(9) (9), 930 - 935, 英語, 国際誌研究論文（学術雑誌）
- BACKGROUND: Rad is the prototypic member of a subfamily of Ras-related small G-proteins and is highly expressed in the skeletal muscle of patients with type II diabetes. Our previous microarray analysis suggested that Rad may mediate fracture nonunion development. Thus, the present study used rat experimental models to investigate and compare the gene and protein expression patterns of both Rad and Rem1, another RGK subfamily member, in nonunions and standard healing fractures. METHODS: Standard healing fractures and nonunions (produced via periosteal cauterization at the fracture site) were created in the femurs of 3-month-old male Sprague-Dawley rats. At post-fracture days 7, 14, 21, and 28, the fracture callus and fibrous tissue from the standard healing fractures and nonunions, respectively, were harvested and screened (via real-time PCR) for Rad and Rem1 expression. The immunolocalization of both encoded proteins was analyzed at post-fracture days 14 and 21. At the same time points, hematoxylin and eosin staining was performed to identify the detailed tissue structures. RESULTS: Results of real-time PCR analysis showed that Rad expression increased significantly in the nonunions, compared to that in the standard healing fractures, at post-fracture days 14, 21, and 28. Conversely, immunohistochemical analysis revealed the immunolocalization of Rad to be similar to that of Rem1 in both fracture types at post-fracture days 14 and 21. CONCLUSIONS: Rad may mediate nonunion development, and thus, may be a promising therapeutic target to treat these injuries.2019年12月, BMC musculoskeletal disorders, 20(1) (1), 602 - 602, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年12月, Annals of translational medicine, 7(Suppl 8) (Suppl 8), S286, 英語, 国際誌
- BACKGROUND: Carbon dioxide therapy has been reported to be effective in treating certain cardiac diseases and skin problems. Although a previous study suggested that transcutaneous carbon dioxide application accelerated fracture repair in association with promotion of angiogenesis, blood flow, and endochondral ossification, the influence of the duration of carbon dioxide application on fracture repair is unknown. The aim of this study was to investigate the effect of the duration of transcutaneous carbon dioxide application on rat fracture repair. METHODS: A closed femoral shaft fracture was created in each rat. Animals were randomly divided into four groups: the control group; 1w-CO2 group, postoperative carbon dioxide treatment for 1 week; 2w-CO2 group, postoperative carbon dioxide treatment for 2 weeks; 3w-CO2 group, postoperative carbon dioxide treatment for 3 weeks. Transcutaneous carbon dioxide application was performed five times a week in the carbon dioxide groups. Sham treatment, where the carbon dioxide was replaced with air, was performed for the control group. Radiographic, histological, and biomechanical assessments were performed at 3 weeks after fracture. RESULTS: The fracture union rate was significantly higher in the 3w-CO2 group than in the control group (p < 0.05). Histological assessment revealed promotion of endochondral ossification in the 3w-CO2 group than in the control group. In the biomechanical assessment, all evaluation items related to bone strength were significantly higher in the 3w-CO2 group than in the control group (p < 0.05). CONCLUSIONS: The present study, conducted using an animal model, demonstrated that continuous carbon dioxide application throughout the process of fracture repair was effective in enhancing fracture healing.2019年10月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(5) (5), 886 - 891, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: Accurate orientation of acetabular and femoral components is important during total hip arthroplasty (THA). In recent years, several navigation systems have been developed. However, these navigation systems for THA are unpopular worldwide because of their high cost. We assessed the orientation accuracy of cups inserted using a disposable accelerometer-based portable navigation system for THAs. METHODS: This was a prospective cohort study. We analyzed 63 hips with navigation prospectively and 30 hips without navigation retrospectively as historical control. The patients underwent THA via the mini anterolateral approach in the supine position using an accelerometer-based portable navigation system. We compared the preoperative target angles, intraoperative cup angles using navigation records, postoperative angles using postoperative CT data, measurement errors of cup angles, and clinical parameters such as sex, treated side, age at surgery, and body mass index (BMI). RESULTS: The average absolute error (postoperative CT-navigation record) was 2.7 ± 2.1° (inclination) and 2.7 ± 1.8° (anteversion), and the absolute error (postoperative CT-preoperative target angle) was 2.6 ± 1.9° (inclination) and 2.7 ± 2.2° (anteversion). The absolute error between postoperative CT and target angle with navigation was significantly lower than the error without navigation (inclination; p = 0.025, anteversion; p = 0.005). Cup malalignment (absolute difference of inclination or anteversion between postoperative CT and preoperative target angle of over 5°) was significantly associated with BMI value (OR: 1.3, 95% CI: 1.1-1.7). The absolute measurement error of cup inclination and anteversion was significantly correlated with patients' BMI (inclination error: correlation coefficient = 0.53, p < 0.001, anteversion error: correlation coefficient = 0.58, p < 0.001). CONCLUSIONS: The clinical accuracy of accelerometer-based portable navigation is precise for the orientation of cup placement, although accurate cup placement was affected by high BMI. This is the first study to report the accuracy of accelerometer-based portable navigation for THA in the supine position.2019年10月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(4) (4), 612 - 617, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 膝窩動脈閉塞症は、塞栓子が末梢動脈を突然閉塞し組織虚血に陥る塞栓症と、慢性閉塞性病変に内膜損傷やアテローム性プラークの破綻などが加わって発症する血栓症に大別され、慢性虚血による側副血行路が既に発達している血栓症では比較的緩徐な経過をとることが多いとされている。今回、TKA後に発症した膝窩動脈閉塞症を2例経験し、いずれも側副血行路が発達しており、足背動脈の触知も可能であっため保存的治療を選択し、良好な経過が得られたので報告した。(一社)中部日本整形外科災害外科学会, 2019年09月, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 803 - 804, 日本語
- 症例1は74歳女で、2年前にCharcot-Marie-Tooth病(CMT)と診断され、右膝の不安定性により立位保持困難となり当科を受診した。右膝関節に高度な外反変形と著明な内側不安定性を認め、ROMは-5〜130°、FTAは150°であった。CMTに伴うCharcot関節の診断で拘束型TKA(Rotating Hinge Knee)を行い、術後1年でROMは0〜110°、FTAは176°に改善し、立位保持可能となった。症例2は90歳女で、6年前に四肢遠位の筋力低下が出現し、CMTと診断された。左膝関節に高度な外反変形と著明な内側不安定性を認め、当科受診した。ROMは0〜100°、FTAは137°であった。CMTに伴うCharcot関節の診断で拘束型TKA(Rotating Hinge Knee)を行い、術後1年でFTAは175°に改善し、シルバーカー歩行可能となった。(一社)中部日本整形外科災害外科学会, 2019年09月, 中部日本整形外科災害外科学会雑誌, 62(5) (5), 805 - 806, 日本語
- Background: Data of vitamin D sufficiency in Asian patients with osteoporotic fragility hip fractures are limited. This study aimed to obtain data from the Japanese population. Methods: Patients aged 60 years or older with hip fractures were prospectively enrolled. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured. Levels were compared between patients receiving and not receiving treatment for osteoporosis, those with and without previous contralateral hip fractures, and those with femoral neck versus trochanteric fractures. Sex-based differences were also assessed. The serum levels in patients younger than 60 years with extremity fractures were assessed, and differences between elderly and younger patients were evaluated. The individual correlation between 25(OH)D levels and the ultraviolet (UV) index and age was analyzed in elderly patients with hip fractures. Results: The data of 360 patients (aged 84.7 +/- 8.2 years), comprising 80 men and 280 women, were analyzed. The mean 25(OH)D level was 16.5 +/- 7.2 ng/mL. The prevalence of vitamin D insufficiency (25(OH)D <30 ng/mL) and deficiency (25(OH)D <20 ng/mL) was 93.9% and 71.7%, respectively. A significant difference was noted in the prevalence of vitamin D deficiency between patients with and without previous contralateral hip fractures. Age and 25(OH)D levels were found to be correlated, with no correlation between the UV index and the 25(OH)D levels. The 25(OH)D level in the younger population (n = 123) was 20.7 +/- 8.6 ng/mL, which was significantly higher than that of the elderly. Conclusion: Perennial vitamin D insufficiency is prevalent in elderly Japanese patients with hip fractures.SAGE PUBLICATIONS LTD, 2019年09月, Journal of orthopaedic surgery (Hong Kong), 27(3) (3), 2309499019877517, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND: Soft-tissue balance is an important element for the success of total knee arthroplasty; however, the influence of intraoperative soft-tissue balance on knee kinematics in posterior-stabilized-total knee arthroplasty remains unknown. We investigated whether intraoperative soft-tissue balance could influence knee kinematics and flexion angle after posterior-stabilized-total knee arthroplasty. METHODS: This study included 30 patients with knee osteoarthritis and varus alignment who underwent posterior-stabilized total knee arthroplasty; intraoperative soft-tissue balance parameters, such as varus ligament balance and joint component gap, were assessed by an offset-type tensor at knee flexion angles of 0°, 10°, 30°, 60°, 90°, 120°, and 135°. Medial and lateral compartment gaps were calculated. The amount of tibial internal rotation was determined between 60° and 135° flexion by the navigation system. Simple linear regression analysis was used to analyze the effects of intraoperative soft-tissue balance on tibial internal rotation. Linear regression analysis was used to assess correlation between tibial internal rotation and postoperative knee flexion angle. FINDINGS: Medial compartment gaps at 60° (r = -0.57, P < 0.05) and 90° (r = -0.60, P < 0.05) of flexion were significantly negatively correlated with tibial internal rotation. Moreover, tibial internal rotation showed a significant correlation with the 2-year postoperative knee flexion angle (r = 0.50, P < 0.05) and improvement in knee flexion angle (r = 0.61, P < 0.05). INTERPRETATION: Thus, smaller medial compartment gaps at 60° and 90° of flexion play an important role in achieving medial pivot motion with tibial internal rotation; moreover, tibial internal rotation provides a better flexion angle after posterior-stabilized total knee arthroplasty.2019年08月, Clinical biomechanics (Bristol, Avon), 68, 16 - 22, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: This study aimed to examine the accuracy of tibial implant alignment using an accelerometer-based portable navigation system in unicompartmental knee arthroplasty (UKA). METHODS: This retrospective matched case-control study reviewed 51 UKAs performed using an accelerometer-based portable navigation system, matched with 51 UKAs performed using conventional extramedullary rods. Coronal alignment and posterior slope of the tibial implant were measured on postoperative radiographs, and differences from preoperative planning were examined. Outliers and accuracy of tibial implant alignment were compared between the portable navigation and conventional groups using Fisher's exact test and Mann-Whitney U test, respectively. RESULTS: In the portable navigation group, 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. In the conventional group, 76.5% and 88.2% of the implants were within 3.0° of both target coronal and sagittal implant alignment. Statistical analysis revealed that outliers of coronal and sagittal alignment were significantly less in the portable navigation group than in the conventional group (P < 0.05). In addition, the absolute value difference between postoperative measurement and preoperative planning of both coronal and sagittal alignment was significantly smaller in the portable navigation group than in the conventional group (P < 0.05). CONCLUSION: The portable navigation system improved the accuracy of tibial implant alignment in UKA. We found that 100% of the implants were aligned within 3.0° of both target coronal and sagittal implant alignment. The portable navigation system decreased the outliers of tibial coronal and sagittal alignment. LEVEL OF EVIDENCE: Retrospective case-control study, Level III.2019年08月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2917 - 2923, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissue leads to the formation of pannus, which invades joint cartilage and bone resulting in joint destruction. Tumor necrosis factor-like ligand 1A (TL1A), a member of the tumor necrosis factor superfamily (TNFSF15), contributes to the pathogenesis of autoimmune diseases, including RA. In the present study, a cDNA microarray was used to search for genes whose expression in rheumatoid fibroblast-like synoviocytes (RA-FLS) were regulated by TL1A. Four individual lines of primary cultured RA-FLS were incubated either with recombinant human TL1A protein or phosphate-buffered saline, as an unstimulated control, for 12 h. Gene expression was then detected through the microarray assay. The results revealed the expression profiles of genes in RA-FLS regulated by TL1A. The present study also demonstrated the functions of those genes whose expression in RA-FLS was regulated by TL1A. Among the genes in this profile, the present study focused on the following genes: Spectrin repeat-containing nuclear envelope 1, Fc receptor-like 2, PYD (pyrin domain)-containing 1, cell division cycle 45 homolog, signal transducer and activator of transcription 5B, and interferon regulatory factor 4. These genes may affect the pathogenesis of RA, including proliferation, regulation of B cells and T cells, inflammation, and cytokine processing. The present study revealed for the first time, to the best of our knowledge, the expression profile of genes in RA-FLS regulated by TL1A. The data indicate that TL1A may regulate the gene expression of various key molecules in RA-FLS, thus affecting the pathogenesis of RA. Further investigations of the genes detected in the current profiles may provide a deeper understanding of the pathogenesis and a novel target for the treatment of RA.2019年07月, Biomedical reports, 1(1) (1), 1 - 5, 英語, 国際誌[査読有り]
- PURPOSE: To investigate the correlation between intraoperative tibiofemoral anteroposterior changes at 90° of flexion and postoperative maximum flexion angles in navigated cruciate-substituting TKA. The hypothesis of this study was that intraoperative tibiofemoral anteroposterior changes at 90° of flexion indirectly reflect posterior cruciate ligament (PCL) function and associate with postoperative maximum flexion angles. METHODS: Fifty-five consecutive patients with varus osteoarthritis treated with primary TKA were retrospectively analysed. All patients received the same type of implant, placed with an image-free navigation system. The PCL was retained, and cruciate-substituting inserts were used in all cases. The mean follow-up was 44 ± 8 months. The preoperative and postoperative kinematics were measured intraoperatively with a navigation system, and the preoperative and postoperative tibiofemoral anteroposterior positions at 90° of flexion were determined. The correlation between intraoperative anteroposterior position changes and postoperative maximum flexion angles was investigated. The correlation between the change of anteroposterior position and tibiofemoral rotational angles was also assessed. RESULTS: The intraoperative anteroposterior position change was -1.7 ± 3.4 mm (a positive value indicates tibial posterior shift). Flexion angle improvement was negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.17, p < 0.005). Postoperative maximum flexion angles were also negatively correlated with intraoperative change of tibiofemoral anteroposterior position (R2 = 0.09, p < 0.05). The postoperative amount of tibial internal rotation was positively correlated with the preoperative amount (R2 = 0.60, p < 0.0001); however, the intraoperative anteroposterior position change was not correlated with the postoperative amount of tibial internal rotation (n.s.). CONCLUSION: A navigation system may be able to indirectly evaluate PCL function and predict the postoperative flexion angles in cruciate-substituting TKA. Intraoperative posterior movement of the tibia at 90° of flexion predicts worse postoperative flexion angles in cruciate-substituting TKA. LEVEL OF EVIDENCE: Level 3, retrospective comparative study.2019年07月, Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 28(9) (9), 2816 - 2822, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUNDS: There are very few reports on pelvic movement during total hip arthroplasty (THA) in the supine position. We investigated intraoperative pelvic motion in the sagittal and axial planes to determine if preoperative clinical factors, including body mass index (BMI) affect intraoperative pelvic motion. METHODS: Fifty-three patients with osteoarthritis undergoing THA in the supine position were included. Clinical factors, such as age, BMI, and pelvic tilt were assessed preoperatively. Intraoperative pelvic motion in the axial and sagittal planes was assessed using a portable navigation system. We assessed the change in pelvic tilt from registration to cup implantation as the pelvic tilt change; positive values indicated anterior pelvic tilt. We measured the values and absolute values of changes in axial rotation from registration to cup implantation to determine the axial rotation angle. The effects of patient factors on pelvic motion (pelvic tilt change and axial rotation angle) were analyzed using a Spearman's correlation analysis. RESULTS: Preoperative pelvic tilt was negatively correlated with pelvic tilt change (r = -0.57, p < 0.05) and the absolute axial rotation angle (r = -0.57, p < 0.05). BMI and absolute axial rotation angle were negatively correlated (r = -0.54, p < 0.05). Age was not correlated with change in the pelvic tilt and the axial rotation angle. CONCLUSIONS: Preoperative pelvic tilt and BMI are important factors to determine intraoperative pelvic motion in patients who undergo THA in the supine position. This can help surgeons to preoperatively identify patients with a higher risk of intraoperative pelvic motion.2019年06月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25(3) (3), 446 - 451, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- Recently, kinematically aligned total knee arthroplasty has been found to achieve better clinical outcomes than mechanically aligned TKA. Despite the good clinical outcomes that are reported at short- to mid-term follow-up, intraoperative variables that are associated with a better outcome have not been measured. Therefore, this study was conducted to compare intraoperative kinematics/soft tissue balance and the clinical outcomes of patients who underwent modified kinematically (restricted tibial cut) or mechanically aligned total knee arthroplasty. Sixty cruciate-retaining total knee arthroplasties (30 modified kinematically [3-degree varus and 7-degree posterior slope in tibial cut] and 30 mechanically aligned) were performed in patients with varus-type osteoarthritis using a navigation system. Intraoperative kinematics assessed by the navigation system and soft tissue balance assessed by an offset-type tensor were compared between the groups. One year postoperatively, the range of motion and 2011 Knee Society scores were compared between the groups. Kinematic assessment exhibited that tibial internal rotation during flexion was significantly maintained in the kinematic compared with the mechanical group (p < 0.05). Varus/valgus ligament balance at 90 and 120 degrees of flexion significantly maintained lateral laxity in the kinematic compared with the mechanical group (p < 0.05). Improvement of flexion angles, functional activity scores, and patient satisfaction were significantly better in the kinematic than in the mechanical group (p < 0.05). Modified kinematically aligned cruciate-retaining total knee arthroplasty maintained more tibial internal rotation and lateral laxity during flexion than mechanically aligned total knee arthroplasty; thus, the former may result in better clinical outcomes.2019年05月, The journal of knee surgery, 33(8) (8), 777 - 784, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Purpose: To assess the accuracy of cup orientation and learning curve of the disposable accelerometer-based portable navigation system for total hip arthroplasty (THA) in the supine position. Methods: A total of 75 patients who underwent THA through the anterolateral supine approach (ALS) with an accelerometer-based portable navigation system for the supine position (HipAlign®) between July 2017 and October 2018 were analyzed in this study. We compared the intraoperative cup angles using navigation records with the postoperative angles using postoperative computed tomography (CT) data. All patients were categorized into the following groups according to the course of three discrete, sequential operative time periods: 1–25 (initial group), 26–50 (intermediate group), and 51–75 (recent group). We compared the accuracy of cup inclination and anteversion among the three groups. The time required for navigation and the operative time of all patients were measured. Results: The average absolute error in measurement (postoperative CT-navigation record) was 2.6° ± 2.7° (inclination) and 2.8° ± 2.7° (anteversion). There were no significant differences among the three groups. The average time required for navigation and the operative time were 365.1 ± 90.3 s and 76.1 ± 1.6 min, respectively. The required time for HipAlign® navigation and operative time were constant in most patients, except for those of the initial five cases. Conclusion: The accelerometer-based portable navigation system provides good accuracy of cup orientation, has a short learning curve, and requires a minimal surgical time for THA in supine position.2019年05月, Journal of orthopaedic surgery (Hong Kong), 27(2) (2), 2309499019848871[査読有り]研究論文（学術雑誌）
- 2019年05月, JBMR Plus., 3(7) (7), 10191 - 10191, 英語Denosumab Treatment Improved Health-Related Quality of Life in Osteoporosis: A Prospective Cohort Study.[査読有り]研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 427 - 427, 日本語関節リウマチの病因・病態-1 関節リウマチの発症年齢に関与する遺伝子の探索[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 517 - 517, 日本語関節リウマチの治療評価と予測-3 ゲノムワイドSNP解析によるトシリズマブの治療有効性と二次無効の予測[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 603 - 603, 日本語FasLはリウマチ滑膜線維芽細胞における様々な遺伝子の発現を制御する[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 605 - 605, 日本語TNF阻害薬による関節リウマチ滑膜組織の組織学的変化の検討[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 618 - 618, 日本語RA患者における関節破壊の特徴によるトシリズマブ有効性の検討[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 682 - 682, 日本語多施設コホートを用いたイグラチモドの治療継続率[査読有り]
- (一社)日本リウマチ学会, 2019年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 63回, 742 - 742, 日本語親子間の遺伝的差異を利用した関節リウマチ感受性遺伝子の探索[査読有り]
- (公社)日本整形外科学会, 2019年03月, 日本整形外科学会雑誌, 93(2) (2), S407 - S407, 日本語関節リウマチ診療におけるトータルマネージメントの意義と重要性 関節リウマチ患者のトータルマネージメントの将来 リハビリテーション科のリウマチセンターへの参画[査読有り]
- Although the definition of atypical femoral fracture (AFF) excludes periprosthetic femoral fracture (PFF), the number of reports about PFF with characteristics of AFF is increasing. We present the case of such a fracture in this report. An 87-year-old woman who underwent bipolar hip arthroplasty for a femoral neck fracture 38 months prior reported left thigh pain with no history of trauma. Radiographs showed a simple transverse fracture at the level of the stem distal end with features of AFF: periosteal thickening of the lateral cortex, a medial spike, and a noncomminuted fracture. She presented other features resembling AFF: history of bisphosphonate use, prodromal symptoms, no associated trauma, and lateral bowing of the contralateral femur. The fracture showed nonunion after the initial osteosynthesis, and a revision surgery of the arthroplasty and osteosynthesis was performed. Nine months after the surgery, bony union was achieved and she regained the ability to walk. It is supposed that the fracture was influenced by a stress force related to implants and lateral bowing concentrating on the fracture site as a mechanical factor in addition to bisphosphonates as a biological factor. It would be important to recognize that AFF could occur at the peri-implant location, and early detection and treatment are essential.2019年, Case reports in orthopedics, 2019, 1275369 - 1275369, 英語, 国際誌[査読有り]
- Coagulation factor XIII (FXIII) is the final enzyme in the coagulation cascade and plays an important role in catalyzing the intermolecular cross-linking of fibrin polymers. FXIII deficiency is a rare disorder that presents with recurrent soft tissue bleeding. In this case report, we describe a patient with recurrent hematomas, following a revision total hip arthroplasty (THA). A 50-year-old female patient with no past history of bleeding and with a normal perioperative coagulation profile presented with recurrent hip joint hematomas. Her plasma FXIII activity showed a slight decrease (69%). Therefore, the patient was diagnosed with an acquired deficiency and was administered FXIII to correct it. The bleeding did not recur once the FXIII activity had returned to a normal level (76%). At 2 months after the second evacuation procedure, the patient was discharged from the hospital in an ambulatory state. There has been no recurrence of a hematoma since. We managed a rare case of acquired FXIII deficiency, which highlighted that a patient can present with an acquired bleeding disorder despite having a normal coagulation profile. An acquired FXIII deficiency should be suspected in patients with inexplicable, sudden-onset bleeding, as early diagnosis and treatment are important to prevent life-threatening complications.2019年, Case reports in orthopedics, 2019, 4038963 - 4038963, 英語, 国際誌[査読有り]
- Introduction: Osteogenesis imperfecta (OI) is a heritable disorder of connective tissue. Due to poor bone quality, patients with OI develop bone fracture and subsequent non-union at high rates. We report the rare case of humeral shaft non-union successfully treated by a locking plate used formandibular bone in a patient with OI. Case Report: A 26-year-old man with Type III OI and a history of corrective osteotomy with Kirschner wire fixation of his right humerus at the age of 8 years developed gradually increasing pain in his humerus. He sustained humeral shaft non-union due to a broken Kirschner wire used in the previous operation and was referred to our hospital. He underwent internal fixation using an elastic nail with an iliac bone graft. However, 2 years after the operation, bony union was not achieved due to elastic nail breakage, and he complained of pain and activity limitation. He underwent re-operation for the humeral non-union using a locking plate to achieve rigid fixation. Because his humeral shaft was extremely narrow with severe deformity, we used a locking plate for the mandibular bone, which was contoured to fit the medial side of the humeral shaft. Bony union was achieved, the pain was relieved, and the patient returned to his pre-injury activity with no symptoms.4years after the operation, a new fracture line was found in radiographs of the distal part of the non-union. Bony union was achieved by conservative treatment. At present, the function has recovered. Conclusion: Humeral non-union in this patient with OI was successfully treated by a mandible locking plate. Although the optimal fixation device for fractures or non-unions in patients with OI has not yet been established, this plate could be a good treatment option for narrow and severely deformed bone.2019年, Journal of orthopaedic case reports, 9(3) (3), 19 - 21, 英語, 国際誌[査読有り]
- 関節リウマチ患者に対するTNF阻害薬の10年を超える治療継続率の比較目的:日本では2003年にインフリキシマブ(IFX)が、2005年にエタネルセプト(ETN)が、2008年にアダリムマブ(ADA)がRA治療に適応となった。また、ADAは2003年より治験によるRA治療が行われている。今回、我々はこれら3剤の10年以上の治療継続率を評価したので報告する。対象・方法:2007年以前に松原メイフラワー病院にてIFX、ETN、ADAを開始し、10年以上の経過観察が可能であったRA患者を対象とした。IFXは111例に投与され、そのうち10年以上の観察が可能であった95例を対象とした。ETNは119例中95例、ADAは27例中24例を対象とした。各製剤の継続率をKaplan-Meier生存曲線を用いて検討した。結果:Kaplan-Meier生存曲線にて、3剤の継続率に統計学的有意差は認めなかった。治療開始後12年時の治療継続率はIFXで10.5%、ETNで22.1%、ADAで8.3%であった。IFXの治療継続率にはIFX開始時のDAS28(CRP)が、ETNの治療継続率には発症時年齢がそれぞれ負の相関を認めた。寛解による中止の割合はADAで最も高かった。結論:今回の検討では、3剤の継続率に統計学的有意差を認めなかったが、10年以上の継続率はETNで最も高く、ADAで最も低かった。(著者抄録)(一社)日本臨床リウマチ学会, 2018年12月, 臨床リウマチ, 30(4) (4), 269 - 275, 日本語[査読有り]
- BACKGROUND: The relationship between postoperative limb alignment and clinical outcomes in primary total knee arthroplasty (TKA) is well reported, but the instruments used to evaluate clinical outcomes of TKA are mainly scoring systems from the physician's viewpoint, not patient-reported outcomes. The purpose of this study was to investigate retrospectively the relationship between postoperative limb alignment and patient-reported clinical outcomes using the 2011 Knee Society Knee Scoring System (2011 KSS). METHODS: The present study included 155 knees of patients (median age, 74 years) who underwent primary TKA for varus osteoarthritis, with a mean follow-up period of 46 months. The subjects were divided into three groups based on postoperative limb alignment and femoral and tibial component positioning angle (varus, neutral, and valgus). The 2011 KSS scores were compared among the groups. RESULTS: For limb alignment, the postoperative objective knee indicator score was significantly lower in the valgus group than in the varus and neutral groups, whereas no significant differences were observed in any subjective categories of the 2011 KSS. However, for the femoral component angle, functional activity scores were significantly lower in the valgus group than in the varus and neutral groups. CONCLUSIONS: The subjective patient-reported score was not affected by the postoperative limb alignment. However, the valgus femoral component angle resulted in lower subjective functional scores. For clinical relevance, postoperative valgus positioning of femoral component should be avoided from patient-reported functional aspects during TKA.2018年12月, J Orthop Sci, 24(4) (4), 668 - 673, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年12月, J Bone Miner Res, 33(12) (12), 2242 - 2242, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: This study aimed to determine the correlation between the change in joint line height calculated from the resected bone and insert thickness during surgery and the change in limb alignment following unicompartmental knee arthroplasty (UKA). It was hypothesized that joint line elevation is correlated with the change in limb alignment. METHODS: A total of 74 consecutive patients diagnosed with either isolated medial compartmental osteoarthritis (38 patients) or spontaneous osteonecrosis of the knee (36 patients) were included. The thickness of the proximal tibial and distal femoral bony cuts was measured during surgery; using these values, the medial joint line elevation of the tibia (MJLET) and medial joint line reduction of the femur (MJLRF) were defined. The correlation between the amount of change in the hip-knee-ankle (HKA) angle before and after surgery (δHKA) and the thickness of the tibial insert (TI), MJLET, or MJLRF were evaluated. RESULTS: The mean values of δHKA, TI, MJLET, and MJLRF were 5.0° ± 2.6°, 8.5 ± 0.8, 4.4 ± 1.3, and 0.0 ± 1.1 mm, respectively. The δHKA had a significant, but weak-positive correlation with the TI (P = 0.02), and moderate-positive correlation with MJLET (P < 0.001). However, no correlation was observed between δHKA and MJLRF. CONCLUSIONS: The MJLET measured during surgery had a significant moderate-positive correlation with the change in limb alignment following medial UKA. For clinical relevance, the surgeon can predict postoperative limb alignment after UKA by considering, intraoperatively, both the insert thickness and the depth of resection at the proximal tibia thus minimizing technical error to obtain an optimal alignment after UKA. LEVEL OF EVIDENCE: Diagnostic study, level II.2018年11月, Knee Surg Sports Traumatol Arthrosc, 26(11) (11), 3468 - 3473, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: The aim of study is to evaluate the accuracy of a navigation system during curved peri-acetabular osteotomy (CPO). METHODS: Forty-seven patients (53 hips) with hip dysplasia were enrolled and underwent CPO with or without navigation during surgery. Clinical and radiographical evaluations were performed and compared between the navigation group and non-navigation group, post-operatively. RESULTS: The clinical outcomes were not significantly different between the navigation and non-navigation groups. Furthermore, post-operative reorientation of the acetabular fragment was similar between the navigation and non-navigation groups. However, the discrepancy between the pre-operative planning line and post-operative osteotomy line was significantly improved in the navigation group compared with that in the non-navigation group (p < 0.05). Further, the complication rate was significantly improved in the navigation group (p < 0.001). CONCLUSION: The accuracy of the osteotomy's position was significantly improved by using the navigation. Therefore, the use of navigation during peri-acetabular osteotomy can avoid complications.2018年11月, Int Orthop, 42(11) (11), 2555 - 2561, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- BACKGROUND: This study aimed to determine the appropriate administration duration of edoxaban 15 mg (a factor Xa inhibitor) for the prevention of deep vein thrombosis (DVT) after total knee arthroplasty (TKA). METHODS: Our study comprised 202 patients who underwent TKA (excluding bilateral TKA) at our institution between 2014 and 2015. The subjects received edoxaban 15 mg daily for 1 (n = 93) or 2 (n = 109) weeks; group assignment was random. B-mode ultrasonography was performed 7 and 14 days post-TKA for the detection of DVT. We compared the incidence of DVT between the groups and examined for side effects. RESULTS: The demographic data of the patients in the 1- and 2-week administration groups were similar at baseline. DVT incidence did not differ significantly between the groups at 1 week post-TKA. However, it was significantly lower in the 2-week administration group (n = 0) than in the 1-week administration group (n = 7; p = 0.004) at 2 weeks post-DVT. Neither group exhibited symptomatic DVT. A total of six patients withdrew during the study period because of hepatic dysfunction. CONCLUSIONS: Our results show that the administration of edoxaban 15 mg is more effective in preventing DVT after TKA when administered for 2 weeks than for 1 week.2018年11月, J Orthop Sci, 23(6) (6), 1005 - 1010, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- 2018年10月, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 英語, 国内誌[査読有り]研究論文（学術雑誌）
- The role of uncultured adipose-derived stromal cells for osteoarthritis treatment remains unclear despite sporadic reports supporting their use in clinical settings. This study aimed to evaluate the therapeutic effects of autologous uncultured adipose-derived stromal cell transplantation in a rabbit osteoarthritis model. Uncultured adipose-derived stromal cells isolated from rabbits were administered via intra-articular injection into the knees after osteoarthritis onset. Animals were sacrificed at 8 and 12 weeks after osteoarthritis onset to compare the macroscopic, histological, and immunohistochemical characteristics between the uncultured adipose-derived stromal cell and control groups. Co-culture assay was also performed. The chondrocytes isolated from the model were co-cultured with adipose-derived stromal cells. The cell viability of chondrocytes and expression of chondrocyte-specific genes in the co-culture (uncultured adipose-derived stromal cell) group were compared with the mono-culture (control; chondrocytes only) group. In macroscopic and histological analyses, the uncultured adipose-derived stromal cell group showed less damage to the cartilage surface than the control group at 8 and 12 weeks after osteoarthritis onset. In immunohistochemical and co-culture assay, the uncultured adipose-derived stromal cell group showed higher expression of collagen type II and SRY box-9 and lower expression of matrix metalloproteinase-13 than the control group. The cell viability of chondrocytes in the uncultured adipose-derived stromal cell group was higher than that in the control group. Intra-articular autologous uncultured adipose-derived stromal cell transplantation inhibited the progression of cartilage degeneration in a rabbit osteoarthritis model by regulating chondrocyte viability and secreting chondrocyte-protecting cytokines or growth factors, which promote anabolic factors and inhibit catabolic factors. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1376-1386, 2019.2018年10月, J Orthop Res, 37(6) (6), 1376 - 1386, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2018年09月, 中部日本整形外科災害外科学会雑誌, 61(秋季学会) (秋季学会), 134 - 134, 日本語関節リウマチの生物製剤治療におけるSNPアルゴリズムの有用性[査読有り]
- Recent advances in surgical tools such as navigation systems have contributed to accurate implantation in total knee arthroplasty. Although several navigation systems have been developed, reports regarding which navigation system has better accuracy are few. Therefore, this study aimed to compare the accuracy of postoperative coronal alignment among 3 navigation systems. A total of 90 knee prostheses were implanted for 90 patients with osteoarthritis. Thirty patients were enrolled in each of the following 3 navigation groups: Stryker Navigation System II (computed tomography-free navigation; Stryker, Mahwah, New Jersey); OrthoPilot version 4.2 navigation system (computed tomography-free navigation; B. Braun Aesculap, Tuttlingen, Germany); and VectorVision navigation system (computed tomography-based navigation system; BrainLAB, Munich, Germany). Thirty consecutive total knee arthroplasties performed via the conventional method without navigation were selected as a control group for comparison with the navigation groups. Postoperative coronal mechanical axis and femoral and tibial coronal component angles were compared among the groups using long-leg standing radiographs for the rate of outliers beyond 3°. No differences were observed in the mean femoral and tibial component angles among the navigation and conventional groups. However, the proportion of outliers beyond 3° was higher in the conventional group than in the 3 navigation groups. No significant differences in the outlying values were found among the 3 navigation groups. These 3 navigation systems achieved equally accurate coronal mechanical alignment with fewer outliers. The navigation systems exhibited more precise implantation than the conventional method. [Orthopedics. 2018; 41(5):e621-e628.].2018年09月, Orthopedics, 41(5) (5), e621 - e628, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年09月, Int J Mol Med, 42(3) (3), 1548 - 1558, 英語Downregulation of aquaporin 9 decreases catabolic factor expression through nuclear factor-κB signaling in chondrocytes[査読有り]研究論文（学術雑誌）
- (公社)日本整形外科学会, 2018年08月, 日本整形外科学会雑誌, 92(8) (8), S1985 - S1985, 日本語関節リウマチ滑膜細胞におけるdecoy receptor 3によるcadherin 2発現誘導の検討[査読有り]
- 2018年08月, Hip Joint, 44(1号) (1号), 13 - 17, 日本語術前評価から考える股関節唇縫合術の適応と手術手技[査読有り]研究論文（学術雑誌）
- PURPOSE: Quality-of-life (QOL) assessments in patients with osteonecrosis of the femoral head (ONFH) have rarely been reported. This multicentre study aimed to elucidate the relationship between disease severity, including necrotic lesion type and radiological staging, and QOL, as well as between patients' characteristics and QOL. METHODS: Two hundred seventy-four patients with ONFH (108 females, 166 males; median age, 46 years) were asked to complete self-assessment QOL questionnaires including the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire, Oxford Hip Score, and SF-12v2. RESULTS: Patients with large necrotic lesion type or collapsed ONFH had low QOL scores. Among patients with non-collapsed lesions, patients with alcohol-associated ONFH had lower QOL scores than those with steroid-associated ONFH, those with bilateral ONFH had lower mental scores, and male patients had worse social condition scores. Among patients with collapsed lesions, middle-aged patients exhibited lower mental QOL, and a strong correlation was observed between social activity and mental health. CONCLUSION: Collapsed ONFH was associated with low QOL scores. Among patients with non-collapsed lesions, alcohol-associated ONFH, bilateral disease, and male sex were linked to low QOL scores.2018年07月, International orthopaedics, 42(7) (7), 1517 - 1525, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Background: The Summit cementless stem has been used as a device to occupy the proximal medullary canal space in total hip arthroplasty (THA). The purpose of this study was to evaluate the mid-term clinical and radiographic results of the Summit stem and the differences in the results as a function of medullary cavity shape. Methods: This study analyzed the 90 consecutive patients who underwent THA by using the Summit cementless stem. The minimum clinical and radiographic follow-up period for the patients was 5 years (mean, 5.5 years range, 5.0–7.1 years). The radiographic and Harris hip scores (HHS) were evaluated across the three Dorr type classifications of femoral bone. Results: The postoperative HHSs were significantly higher than the preoperative HHS scores (p < 0.05). No significant differences in preoperative and postoperative HHSs were found among the three Dorr types. Stress shielding was observed in 58 hips. Spot welds and cortical hypertrophy were observed in various zones in 53 and 11 hips, respectively. No significant difference in the number of occurrences of cortical hypertrophy was found among the three Dorr types. However, the number of occurrences of severe stress shielding in Dorr type C was higher than that in Dorr type B. The number of occurrences of spot welds in Dorr type C was lower than that in both Dorr types A and B. Conclusions: Mid-term clinical results were good regardless of the medullary cavity shape. However, severe stress shielding in Dorr type C was more frequently than that in Dorr type B. Therefore, attention should be paid to the types of medullary cavity shapes for Summit stem use.Elsevier, 2018年07月, Journal of Orthopaedic Science, 23(4) (4), 671 - 675, 英語[査読有り]研究論文（学術雑誌）
- 2018年06月, Genetics, 209(2) (2), 367 - 380, 英語Development and Function of the Drosophila Tracheal System[査読有り]研究論文（学術雑誌）
- Background: Prevalence of developmental hip dysplasia is high in Japan. Exercise therapy has been proven effective to treat certain aspects of hip osteoarthritis. Moreover, therapy provided via digital video discs (DVDs) and websites allows patients to exercise in the comfort of their own homes. However, no studies have evaluated the effectiveness of visual instructions in patients with hip disorders. Objective: This study aimed to compare the effectiveness of exercise therapy administered via DVD and that administered via a website. Methods: We developed a six-step progressive exercise therapy program for patients with hip osteoarthritis, which included three kinds each of open kinetic chain and closed kinetic chain exercises. Once the program was developed, exercise DVDs were produced. In addition to the six-step exercise program, our website was enabled to count the number of exercises performed by each patient and was accessible via the Internet at any time. Patients with hip osteoarthritis for whom surgery was not advised were enrolled by one university hospital in the Kansai area in Japan. Clinical symptoms and hip function were quantified using the Japanese Orthopedic Association Hip Disease Evaluation Questionnaire (JHEQ) and the Oxford Hip Score (OHS). Quality of life was measured using the SF-8 Health Survey, and self-efficacy for continued exercise was measured using the General Self-Efficacy Scale (GSES). Questionnaires were completed preintervention and after 6 months. Results: At 6-month follow-up, 10 DVD users (1 male, 9 female mean age 51.3, SD 16.1 years) and 18 website users (2 male, 16 female mean age 52.4, SD 10.4 years) were reachable. The change in each parameter could not be confirmed a significant improvement. However, most items tended to reflect overall improvement during the 6 months of intervention (P=.05-.94 paired t test). Regarding effect size, we considered a small effect to be greater than 0.2. Little effect was observed for JHEQ pain, SF-8 physical component summary (PCS), and SF-8 mental component summary in the DVD group, as well as OHS, SF-8 (PCS), and GSES in the website group. Conclusions: When comparing the effectiveness of exercise therapy between our DVD and website, we found that although both groups tended to improve in physical function, only the website group showed tendency of enhanced self-efficacy.Journal of Medical Internet Research, 2018年05月, Journal of Medical Internet Research, 20(5) (5), 英語[査読有り]研究論文（学術雑誌）
- Background: Vascular CD34+ cells in anterior cruciate ligament (ACL) tissues have a potential for high proliferation and multilineage differentiation, which can accelerate tendon-bone healing after ACL reconstruction. To predict outcomes of ACL reconstruction with remnant preservation or ruptured tissue incorporation, patient characteristics should be considered. However, the influence of ACL remnant morphologic pattern on healing potential remains unknown. Hypothesis: The healing potential of ACL remnants could differ among their morphologic patterns. Study Design: Descriptive laboratory study. Methods: ACL remnant tissues were harvested from patients aged < 35 years who received primary ACL reconstruction within 3 months after injury. The tissues were evaluated according to the Crain classification (4 patterns). The patterns were divided into 2 groups: the reattachment group (Crain I-III) and the nonreattachment group (Crain IV). ACL remnant cells were characterized via fluorescence-activated cell sorting. The potential for proliferation and multilineage differentiation was assessed and compared between the groups. Results: The ratio of CD34+ cells was significantly higher in the nonreattachment group than in the reattachment group. In early passages, the nonreattachment group had a significantly higher expansion potential than the reattachment group. In the evaluation of osteogenic and endothelial differentiation potential, the nonreattachment group showed a higher potential in immunohistochemical/histochemical staining and quantitative real-time polymerase chain reaction analysis as compared with the reattachment group. Conclusion: In the subacute phase, ACL remnant tissue of the nonreattachment group possibly has a higher healing potential than that of the reattachment group. Clinical Relevance: If healing potential differs among the morphologic patterns of ACL remnants, surgeons may expect the healing potential when preserving remnants.SAGE Publications Inc., 2018年05月, American Journal of Sports Medicine, 46(6) (6), 1382 - 1388, 英語[査読有り]研究論文（学術雑誌）
- 2018年05月, JMIR Rehabil Assist Technol, 5(1) (1), e10, 英語Exercise Therapy Interventions in Patients With Hip Osteoarthritis:Comparison of the Effects of DVD and Website-Based Interventions[査読有り]研究論文（学術雑誌）
- Inflammation serves an important role in the progression of osteoarthritis (OA), and IL-1β may act as a catabolic factor on cartilage, reducing the synthesis of primary cartilage components type II collagen and aggrecan. Aquaporin 1 (AQP1) is a 28-kDa water channel formed of six transmembrane domains on the cell membrane. AQP1 is highly expressed in the anus, gallbladder and liver, and is moderately expressed in the hippocampus, ependymal cells of the central nervous system and articular cartilage. It was hypothesized that AQP1 may be highly expressed in OA cartilage and that it may increase the expression of catabolic factors during inflammatory OA progression. Therefore, the present-study evaluated AQP1 functions in human OA articular chondrocytes. Primary chondrocytes were isolated from human hip and knee cartilage tissues, cultured and transfected with AQP1-specific small interfering RNA with or without-subsequent IL-1β treatment. In vitro explant culture from hip cartilages were also prepared. Reverse transcription-polymerase chain reaction (RT-PCR) was performed to assess the expression of AQP genes in human articular cartilage, AQP1 immunohistochemistry of the cartilages and explant culture, as well as RT-quantitative PCR, western blotting and immunocytochemistry/immunofluorescence of OA chondrocytes to evaluate the expression of AQP1, and catabolic and anabolic factors. RT-PCR results demonstrated that AQP0, 1, 3, 7, 9, and 11 were expressed in OA chondrocytes. Immunohistochemistry revealed that AQP1 was highly expressed in the superficial to middle zones of OA articular cartilages. Additionally, AQP1 mRNA was significantly higher in OA cartilage and IL-1β treatment-significantly increased AQP1 expression in hip explant cartilage. Furthermore, AQP1 downregulation decreased a disintegrin and metalloprotease with thrombospondin motifs (ADAMTS)-4 expression in OA chondrocytes, though it did not affect other associated genes. Immunofluorescence showed that AQP1 and ADAMTS-4 were co-localized. These findings indicated that AQP1 depletion may decrease ADAMTS-4 expression in human OA chondrocytes. Therefore, regulating AQP1 expression may be a strategy to suppress catabolic factors during OA progression.Spandidos Publications, 2018年04月, Mol Med Rep, 17(4) (4), 4874 - 4882, 英語[査読有り]研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2018年03月, 中部日本整形外科災害外科学会雑誌, 61(春季学会) (春季学会), 331 - 331, 日本語RA患者においてデノスマブによる骨粗鬆症治療は患者QOLを改善する[査読有り]
- (一社)日本リウマチ学会, 2018年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 477 - 477, 日本語関節リウマチの病因・病態1 関節リウマチ滑膜細胞におけるCadherin 2の発現はDecoy receptor 3により誘導される[査読有り]
- (一社)日本リウマチ学会, 2018年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 498 - 498, 日本語関節リウマチの病因・病態2 関節リウマチ患者における関節破壊進行の予測はSNPs解析で可能である 多施設コホート研究[査読有り]
- (一社)日本リウマチ学会, 2018年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 569 - 569, 日本語関節リウマチの治療12:病理・病態・バイオマーカー 生物学的製剤治療中のRA患者における単純ヘルペスおよび帯状疱疹ヘルペス発症に関わる遺伝子多型性の検討[査読有り]
- (一社)日本リウマチ学会, 2018年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 62回, 790 - 790, 日本語生物学的製剤の治療継続率の比較 追跡期間10年を超える症例を対象とする[査読有り]
- 2018年03月, International Orthopaedic, doi: 10.1007/s00264-018-3897-8, 英語Quality of life of patients with osteonecrosis of the femoral head: a multicentre study.[査読有り]研究論文（学術雑誌）
- OBJECTIVES: Decoy receptor 3 (DcR3) competitively binds to Fas ligand, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT) and TNF-like ligand 1A (TL1A), thereby preventing their effects. Using a microarray assay, we previously newly identified centrosomal protein 70 kDa (CEP70) as one of the genes whose expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA-FLS) is reduced by DcR3. Here, we investigated the significance of DcR3 regulation of CEP70 for RA-FLS. METHODS: Synovial samples were obtained from RA patients who had never been treated with biologics and from osteoarthritis (OA) patients. CEP70 mRNA expression was quantified using RT-qPCR analysis. CEP70 protein expression was assessed using immunohistochemical and western blot analyses. RESULTS: CEP70 was expressed predominantly in the superficial lining layer in RA synovial tissue. CEP70 expression was dose-dependently downregulated by DcR3-Fc in RA-FLS but was not downregulated in OA-FLS. TL1A antibody prevented the DcR3-Fc inhibitory effects on CEP70 expression in RA-FLS. CONCLUSIONS: These results indicated that DcR3 reduces CEP70 expression in RA-FLS by binding to membrane-bound TL1A and may suppress RA-FLS proliferation. The reduction in CEP70 expression by DcR3/TL1A signaling may control the hyperplasia of RA synovium.2018年03月, Mod Rheumatol., 28(2) (2), 287 - 292, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Background: Deep vein thrombosis (DVT) is one of the main complications following total knee arthroplasty (TKA). In this study, oral administration of 15 mg edoxaban (a factor Xa inhibitor) once daily for 14 days efficiently prevented the incidence of DVT. Our hypothesis was that prothrombin time-international normalized ratio (PT-INR) on the third postoperative day could predict the incidence of DVT following TKA. Methods: In this study, 286 subjects were enrolled and divided into two groups according to the presence or absence of DVT. Several variables [age, body mass index, postoperative D-dimer level, PT-INR, and functional recovery findings (standing)] were analysed to determine the predictors of DVT, and for DVT diagnosis, ultrasonography was performed for seven days after surgery. Results: The PT-INR levels were significantly higher in the group that did not develop DVT (p = 0.01). Further analysis with logistic regression analysis and receiver operating characteristic curve was performed. The PT-INR on the third postoperative day was an independent factor of the incidence of DVT (odds ratio 0.210 p = 0.035). The cut-off PT-INR was calculated to be 1.425. Conclusion: PT-INR level is a useful marker in determining whether 15 mg edoxaban administration can prevent DVT after TKA. It is suggested that increment of edoxaban to control PT-INR over the cut-off point might prevent the incidence of DVT.Springer-Verlag France, 2018年01月, European Journal of Orthopaedic Surgery and Traumatology, 28(1) (1), 103 - 108, 英語[査読有り]研究論文（学術雑誌）
- Consecutive Bilateral Hip Arthroscopy for Symptomatic Bilateral Femoroacetabular Impingement in an Elite Rugby player: A Case ReportWe report a case of concurrent bilateral hip arthroscopy for symptomatic bilateral femoroacetabular impingement (FAI) performed under the single anesthesia on an elite rugby player. A 27-year-old rugby player who played for a top league had bilateral hip joint pain. Physical examination revealed bilateral tenderness in the anterior area of the hips, with positive impingement signs. Based on the findings of hip radiography and magnetic resonance imaging, the patient's symptoms were diagnosed as bilateral FAI with hip labral tears. Bilateral hip arthroscopy under the single anesthesia was performed due to refractory symptoms. He returned to regular rugby games without any symptoms in either hip. Bilateral hip arthroscopic surgery under the single anesthesia should be an effective treatment for typical and symptomatic FAI, even in elite athletes.MEDICAL ASSOC NIPPON MEDICAL SCH, 2017年12月, JOURNAL OF NIPPON MEDICAL SCHOOL, 84(6) (6), 280 - 285, 英語[査読有り]研究論文（学術雑誌）
- 2017年12月, 日本人工関節学会誌, 47, 643 - 644, 日本語Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討[査読有り]研究論文（その他学術会議資料等）
- Arthroscopic Debridement of a Talar Cyst and Bone Grafting with the Osteochondral Autograft Transfer System A Case ReportSimple bone cysts compose approximately 3% of all primary bone tumors and most commonly occur in the metaphyseal regions of the proximal humerus and femur. The percentage of the talus with suspected bone tumors is reported to be 0.003%. Therefore, talar cysts are rare but sometimes present as aggressive lesions, and they can affect any of the tarsal bones. Recently, an arthroscopic approach to these lesions has been developed that is less invasive than conventional open surgery. In the present case study, we profile a 65-year-old female patient who received arthroscopic debridement of a bone cyst from the medial aspect of the talus with the osteochondral autograft transfer system (OATS). By using the OATS core harvester, we penetrated into the tumor. After the cylindrical bone plug was pulled out, the tumor was removed and artificial bone granules were firmly packed into the cavity with intralesional arthroscopy. Then, the cylindrical bone plug previously harvested by OATS was implanted at the site with careful precision. This intervention resulted in a relative restoration of talar dome anatomy and ultimately restored the patient to activity with minimal discomfort. Therefore, arthroscopic debridement with OATS has the potential to be a useful option in dealing with debilitating osteochondral cystic lesions.AMER PODIATRIC MED ASSOC, 2017年11月, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 107(6) (6), 541 - 547, 英語[査読有り]研究論文（学術雑誌）
- PURPOSE: The purpose of this study was to examine the relationship between medial tibial joint line elevation and the improvement of range of motion (ROM) in unicompartmental knee arthroplasty (UKA). The hypothesis was that limited elevation of tibial joint line will improve knee range of motion in UKA. METHODS: Forty-six consecutive medial UKAs were enrolled in this study. Medial tibial joint line elevation was defined as the polyethylene insert and tibial tray thickness minus the tibial osteotomy and sawblade thickness. Positive values indicated an elevation of the tibial joint line. A component gap between the femoral trial prosthesis and the medial tibial osteotomy surface was also examined. Joint loosening was also calculated based on the joint component gap minus insert and tibial tray thickness. The correlation of the medial tibial joint line elevation with joint looseness and postoperative range of motion were analyzed. RESULTS: The mean medial tibial joint line elevation was 4.9 ± 1.1 mm. The medial tibial joint line elevation reduced the improvement of knee extension (R = - 0.43, p < 0.01). The medial tibial joint line elevation was also correlated with reduced loosening of the joint knee extension (R = - 0.42, p < 0.01). This, in turn, resulted in limited improvement of the knee extension angle. Moreover, joint line elevation under 5 mm significantly improved knee extension angle compared to joint line elevation over 5 mm. CONCLUSIONS: The medial joint line elevation of the tibia in UKA reduced the improvement of knee extension angle, due to a reduced joint looseness at knee extension. A tibial joint line elevation greater than 5 mm in UKA should be avoided to prevent postoperative flexion contracture. For the clinical relevance, this study clarified that the medial joint line of the tibia is an important factor to prevent postoperative flexion contracture in UKA. LEVEL OF EVIDENCE: II.2017年11月, Knee Surg Sports Traumatol Arthrosc, 26(6) (6), 1737 - 1742, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Background: Several recent reports define the line from the centre of the femoral head to the lowest point of the calcaneus. The purpose of this study was to comparatively examine the usefulness of the hip-calcaneus (HC) line and hip-ankle (HA) line for the evaluation of lower-limb alignment in healthy individuals and in patients with osteoarthritis (OA). Methods: Participants included 34 healthy individuals (mean age, 26.4 years) and 34 patients with OA (mean age, 74.2 years). Frontal radiographs of the entire lower limb were taken in single- and double-leg stances. For each group, the hip-knee-ankle (HKA) and hip-kneecalcaneus (HKC) angles were assessed and compared within and between stances. In addition, the HA line and HC line were assessed as the passing line in the knee, and were similarly compared. Results: Significant differences between the HKA and HKC angles, and between the HA line and HC line were observed in both groups during both stances. In addition, significant stance-related differences in the HKA and HKC angles, HA line, and HC line were found in the OA group, but not in the healthy group. Conclusions: Our results suggest that the HC line of the lower limb differs from the HA line. Furthermore, single- and double-leg stances should also be considered, especially in patients with OA. These considerations may affect preoperative planning for high tibial osteotomies and INA. (C) 2017 Elsevier B.V. All rights reserved.ELSEVIER SCIENCE BV, 2017年10月, KNEE, 24(5) (5), 1146 - 1152, 英語[査読有り]研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2017年09月, 中部日本整形外科災害外科学会雑誌, 60(秋季学会) (秋季学会), 123 - 123, 日本語Decoy receptor 3は関節リウマチ滑膜細胞におけるCentrosomal protein 70kDaの発現を抑制する[査読有り]
- 2017年09月, J Orthop Surg (Hong Kong), 25(3) (3), 2309499017739478, 英語Stem anteversion mismatch to the anatomical anteversion causes loss of periprosthetic bone density after THA[査読有り]研究論文（学術雑誌）
- Background: The present study aimed to identify the risk factors associated with revision total hip arthroplasty (THA) failure using a Kerboull-type (KT) plate. Methods: We analyzed 77 revision THAs using cemented acetabular components with a KT plate for aseptic loosening between May 2000 and March 2012. We examined the association of bone graft type, acetabular bone defects, age at the time of surgery, preoperative Japanese Orthopaedic Association (JOA) score, postoperative JOA hip score, and body mass index, with radiographic failure as the outcome. Results: The 7.4-year radiographic failure survival rate was 81.6%. The survival rate was significantly different between the beta-tricalcium phosphate (beta-TCP) group and the bulk allograft group (p = 0.019). The survival curves were also significantly different between the beta-TCP group and bulk allograft group (p = 0.036). American Academy of Orthopaedic Surgeons type IV was significantly associated with radiographic failure (odds ratio [OR]: 15.5, 95% confidence interval [CI]: 1.4-175.4; p = 0.032). Conclusions: The midterm outcomes of revision THA indicate that type of bone graft and bone defect size may affect radiographic survival rate when using a KT plate.BIOMED CENTRAL LTD, 2017年09月, BMC MUSCULOSKELETAL DISORDERS, 18(1) (1), 382, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本整形外科学会, 2017年08月, 日本整形外科学会雑誌, 91(8) (8), S1874 - S1874, 日本語前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響
- 2017年08月, Hip Joint, 43(1号) (1号), 238 - 242, 日本語再置換術後日常活動性に影響する因子の検討[査読有り]研究論文（学術雑誌）
- Although appropriate soft tissue balancing is well recognized as essential procedure in total knee arthroplasty (TKA), poor relationship between intraoperative soft tissue balance and physician-reported clinical outcomes was reported. Since physician-derived scores are reported to be poorly related to patient-reported scores, patient-derived outcome scales have received a great deal of attention and have become increasingly important. Thus, it should be clarified whether intraoperative soft tissue balance influences patient-reported clinical outcomes. Therefore, the purpose of this study was to investigate the relationship between intraoperative soft tissue balance and patient-reported clinical outcomes in TKA. A total of 35 TKAs were performed in patients with varus-type osteoarthritis, using the tibia first technique with a navigation system. Soft tissue balance (joint component gap and varus/valgus ligament balance) with femoral component placement and temporarily repaired patellofemoral joint were intraoperatively assessed with an offset-type tensor under 40 lb of joint distraction force. Measurements were performed at 0, 10, 30, 60, 90, and 120 degrees of knee flexion. Subjective clinical outcomes were assessed using the 2011 Knee Society score, which consists of objective knee indicators, patient satisfaction, patient expectations, and functional activities at the minimum 1-year follow-up. The relationship between each parameter in soft tissue balance and subjection clinical score was assessed using a simple linear regression model. Objective knee indicators, especially patient-reported symptoms, showed positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. Patient satisfaction and expectations also exhibited positive correlations with joint component gap difference of 90 to 0 and 120 to 0 degrees. There were no correlations among any parameters of soft tissue balance and functional activities. The other parameters, including varus/valgus ligament balance, showed no statistical correlations with clinical scores. In conclusion, intraoperative soft tissue balance influenced the postoperative clinical outcomes, where a relatively loose flexion gap resulted in higher scores for the parameters of pain, patient satisfaction, and patient expectations.2017年07月, J Knee Surg, 31(6) (6), 573 - 579, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Background We identified preoperative predictors and size of acetabular bone defects for poor return to daily activity after revision total hip arthroplasty. Methods Our analysis was based on outcomes of 140 cases of revision total hip arthroplasty, performed for any reason between May 2001 and March 2013. The Japanese Orthopaedic Association (JOA) score and body mass index (BMI) measured preoperatively, and the University of California Los Angeles (UCLA) activity score and JOA score measured at the 2-year follow-up were evaluated. Acetabular bone defects were classified according to the American Academy of Orthopaedic Surgeons grading system, with further classification of the location and severity of each acetabular bone defect. We compared preoperative clinical factors and postoperative clinical outcomes statistically. Results We found a significant association between the number of revision surgeries and worse postoperative JOA scores and UCLA activity scores. There were significant differences in postoperative JOA scores and UCLA activity scores between patients with partial and global acetabular bone defects. Conclusion Multiple revision surgeries and the size of the acetabular bone defect were predictors of both poorer clinical outcome and greater restriction in postoperative daily activities. Closer attention to the postoperative management of patients with a lower preoperative status is warranted.Churchill Livingstone Inc., 2017年05月, Journal of Arthroplasty, 32(5) (5), 1606 - 1611, 英語[査読有り]研究論文（学術雑誌）
- Osteoarthritis (OA) is a multifactorial disease, and recent data suggested that cell cycle–related proteins play a role in OA pathology. Cyclin-dependent kinase (CDK) inhibitor 1 (p21) regulates activation of other CDKs, and recently, we reported that p21 deficiency induced susceptibility to OA induced by destabilization of the medial meniscus (DMM) surgery through STAT3-signaling activation. However, the mechanisms associated with why p21 deficiency led to susceptibility to OA by the STAT3 pathway remain unknown. Therefore, we focused on joint inflammation to determine the mechanisms associated with p21 function during in vitro and in vivo OA progression. p21-knockout (p21−/−) mice were used to develop an in vivo OA model, and C57BL/6 (p21+/+) mice with the same background as the p21−/− mice were used as controls. Morphogenic changes were measured using micro-CT, IL-1β serum levels were detected by ELISA, and histological or immunohistological analyses were performed. Our results indicated that p21-deficient DMM-model mice exhibited significant subchondral bone destruction and cartilage degradation compared with wild-type mice. Immunohistochemistry results revealed p21−/− mice susceptibility to OA changes accompanied by macrophage infiltration and enhanced MMP-3 and MMP-13 expression through IL-1β-induced NF-κB signaling. p21−/− mice also showed subchondral bone destruction according to micro-CT analysis, and cathepsin K staining revealed increased numbers of osteoclasts. Furthermore, p21−/− mice displayed increased serum IL-1β levels, and isolated chondrocytes from p21−/− mice indicated elevated MMP-3 and MMP-13 expression with phosphorylation of IκB kinase complex in response to IL-1β stimulation, whereas treatment with a specific p-IκB kinase inhibitor attenuated MMP-3 and MMP-13 expression. Our results indicated that p21-deficient DMM mice were susceptible to alterations in OA phenotype, including enhanced osteoclast expression, macrophage infiltration, and MMP expression through IL-1β-induced NF-κB signaling, suggesting that p21 regulation may constitute a possible therapeutic strategy for OA treatment. © 2017 American Society for Bone and Mineral Research.John Wiley and Sons Inc., 2017年05月, Journal of Bone and Mineral Research, 32(5) (5), 991 - 1001, 英語[査読有り]研究論文（学術雑誌）
- This study investigated the mechanical properties of a new rectangular compaction blade and compared this blade with other types of nail. Three types of nail were tested: the Magnum lag screw (Robert Reid Inc, Tokyo, Japan), proximal femoral nail, and Magnum Fid blade (Robert Reid Inc). The nails were inserted into solid rigid polyurethane foam, and the torsional moments were loaded with an Instron testing machine (Instron, Kanagawa, Japan). The force curve was recorded, and the average maximum torque was calculated from this curve. A simulation study was performed with finite element models to determine the mechanism underlying differences in rotational stability. Mechanical testing showed that the new compaction blade had stronger resistance against rotational force than the helical blade and lag screw implants. Finite element analysis also showed that the new compaction blade had stronger resistance to migration of the polyurethane foam cylinder than the other implant types. In addition, the new compaction blade had strong rotational stability. This implant should be useful for the treatment of unstable trochanteric fracture in patients with osteoporosis.Slack Incorporated, 2017年05月, Orthopedics, 40(3) (3), e491 - e494, 英語[査読有り]研究論文（学術雑誌）
- Aims The aim of this study was to compare the post-operative radiographic and clinical outcomes between kinematically and mechanically aligned total knee arthroplasties (TKAs). Patients and Methods A total of 60 TKAs (30 kinematically and 30 mechanically aligned) were performed in 60 patients with varus osteoarthritis of the knee using a navigation system. The angles of orientation of the joint line in relation to the floor, the conventional and true mechanical axis (tMA) (the line from the centre of the hip to the lowest point of the calcaneus) were compared, one year post-operatively, on single-leg and double-leg standing long leg radiographs between the groups. The range of movement and 2011 Knee Society Scores were also compared between the groups at that time. Results The angles of orientation of the joint line in the kinematic group changed from slight varus on double-leg standing to slight valgus with single-leg standing. The mechanical axes in the kinematic group passed through a neutral position of the knee in the true condition when the calcaneus was considered. The post-operative angles of flexion and functional activity scores were significantly better in the kinematic than in the mechanical group (p < 0.003 and 0.03, respectively). Conclusion A kinematically aligned TKA results in a joint line which has a more parallel orientation in relation to the floor during single- and double-leg standing, and more neutral weight-bearing in tMA than a mechanically aligned TKA.BRITISH EDITORIAL SOC BONE JOINT SURGERY, 2017年05月, BONE & JOINT JOURNAL, 99-B(5) (5), 640 - 646, 英語[査読有り]研究論文（学術雑誌）
- AME Publishing Company, 2017年05月, Annals of Translational Medicine, 5(Suppl 1) (Suppl 1), S10, 英語[査読有り]研究論文（学術雑誌）
- Risk factors for late deep infection after total hip arthroplasty in patients with rheumatoid arthritisObjective: Postoperative infections, a serious complication of orthopedic surgery, occur 2-4 times more frequently in patients with rheumatoid arthritis (RA) without adjustment for medication. Some studies have demonstrated a similar risk of postoperative infection following orthopedic surgery regardless of whether patients underwent tumor necrosis factor-alpha (TNF) inhibitor therapy; however, other studies have reported a higher risk with TNF inhibitor use. However, few reports have focused on the correlation between TNF inhibitor use and postoperative late infection. Therefore, we investigated the correlation between TNF inhibitor therapy and serious postoperative late infection in patients with RA who underwent total hip arthroplasty (THA). Methods: Ninety-nine patients with RA who were enrolled in our institution's and Konan Kakogawa Hospital's THA registry between January 2003 and December 2012 were eligible to participate. Data collected included clinical parameters and medications, including biological drugs, disease-modifying antirheumatic drugs, and glucocorticoids. Logistic regression analysis was performed to examine the association between clinical parameters, medications, and the development of postoperative late infection. Results: One risk factor was identified in the multivariate analysis. TNF inhibitor therapy was found to be significantly associated with the development of late infection after THA (biological drugs: OR: 9.5, 95% CI: 1.0-88.8; TNF inhibitor: OR: 11.7, 95% CI: 1.2-109.7). Conclusion: Biological drug therapy, especially TNF inhibitors, may be associated with an increased rate of late deep infection after THA. When the use of TNF inhibitor therapy is considered, rheumatologists must be attentive to patients after THA.PUBLISAUDE-EDICOES MEDICAS LDA, 2017年04月, ACTA REUMATOLOGICA PORTUGUESA, 42(2) (2), 150 - 154, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2017年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 589 - 589, 日本語リウマチ性疾患の基礎研究/サイトカイン・ケモカイン リウマチ滑膜の低ミトコンドリア生合成は滑膜増殖を亢進させ関節破壊の誘導に寄与する[査読有り]
- (一社)日本リウマチ学会, 2017年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 61回, 719 - 719, 日本語FasLによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討[査読有り]
- 当院で2014〜2015年に変形性足関節症に対して片側人工足関節全置換術を施行された患者21例を対象とし、術前と術後3ヵ月時に身体機能の測定を行い比較検討した。測定項目は「足関節背屈ROM」「足関節底屈ROM」「安静時痛(VAS)」「歩行時痛(VAS)」「最大歩行速度」「ストライド長」「ケイデンス」「JSSFスコア」とした。検討の結果、術前に比べて術後3ヵ月時には「足関節底屈ROM」を除く全ての項目で平均値の有意な改善が認められた。国立大学リハビリテーション療法士協議会, 2017年03月, 国立大学リハビリテーション療法士学術大会誌, 38回(38回) (38回), 44 - 48, 日本語[査読有り]研究論文（その他学術会議資料等）
- Permanent patellar dislocation with tibiofemoral joint osteoarthritis is a relatively rare condition. To treat this condition, total knee arthroplasty with proximal or distal realignment of the extensor mechanism has been reported. We report a challenging case of an 80-year-old woman diagnosed with permanent patellar dislocation with tibiofemoral joint osteoarthritis treated by a mobile bearing total knee arthroplasty utilizing navigation system. Lateral retinaculum release was performed to improve patellar tracking; other proximal or distal realignment of the extensor mechanism was not necessary. Postoperative radiographs show stable patellar tracking and recurrent patellar dislocation was not observed. This clinical case indicates that the implant's precise alignment and rotation during total knee arthroplasty could settle anatomical abnormalities of permanent patellar dislocation and the mobile bearing insert could contribute to stabilizing patellar tracking.2017年, Case Rep Orthop, 2017, 1230412 - 1230412, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本理学療法士協会, 2016年10月, 理学療法学, 43(Suppl.2) (Suppl.2), P - 2, 日本語人工股関節全置換術後感染患者の機能的予後 人工関節温存術・二期的再置換術を施行した5症例の検討
- (公社)日本理学療法士協会, 2016年10月, 理学療法学, 43(Suppl.2) (Suppl.2), O - 2, 日本語人工足関節全置換術患者における術前後の身体機能の変化 術後の最大歩行速度に関連する因子の検討
- 2016年09月, 日本骨粗鬆症学会雑誌, 2(Suppl.1) (Suppl.1), 222, 日本語人工股関節置換術後のステム周囲の骨密度は術後の活動性と相関する研究論文（その他学術会議資料等）
- 2016年09月, 中部日本整形外科災害外科学会雑誌, 59(秋季学会) (秋季学会), 237, 日本語Summit stem使用症例の中期成績研究論文（その他学術会議資料等）
- 2016年08月, 日本整形外科スポーツ医学会雑誌, 36(4号) (4号), 329, 日本語足関節外側靱帯損傷に対する治療戦略 新鮮足関節外側靱帯損傷に対する治療の第1選択は保存療法である研究論文（その他学術会議資料等）
- 2016年08月, 日本整形外科学会雑誌, 90(8号) (8号), S1768, 日本語正常ヒト関節軟骨細胞におけるAQP9の検討[査読有り]研究論文（その他学術会議資料等）
- (公社)日本整形外科学会, 2016年08月, 日本整形外科学会雑誌, 90(8) (8), S1421 - S1421, 日本語[査読有り]研究論文（その他学術会議資料等）
- 2016年08月, 日本整形外科学会雑誌, 90(8号) (8号), S1470, 日本語エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する[査読有り]研究論文（その他学術会議資料等）
- 2016年06月, The Japanese Journal of Rehabilitation Medicine, (JARM2016) (JARM2016), I46, 日本語関節リウマチ患者の骨粗鬆症に対する抗RANKL抗体製剤デノスマブの使用経験[査読有り]研究論文（その他学術会議資料等）
- Aims: The present study aimed to evaluate periprosthetic bone mineral density (BMD) changes around a cementless short tapered-wedge stem used for total hip arthroplasty (THA) and to determine the correlation between BMD changes and stem alignment after THA. Methods: The study included 21 patients (21 joints) who underwent THA with a TriLock stem. At baseline and 6, 12, 18, and 24 months postoperatively, the BMDs in the 7 Gruen zones were evaluated using dual-energy X-ray absorptiometry. BMD changes and stem alignment, that is, anteversion, varus, and anterior tilt, were correlated. Results: Minimal BMD changes were found in the distal femur (Gruen zones 3, 4, and 5), but significant BMD loss was noted in zone 7. BMD loss was also noted in zone 1 at 6 and 12 months postoperatively, but it recovered after 18 months. No correlation was found between BMD changes and anterior tilt. However, significant negative correlations were found between BMD changes and anteversion. Furthermore, significant negative correlations were found between BMD changes and varus in Gruen zone 1, while positive correlations were found between BMD changes and varus in Gruen zone 7. Conclusions: We demonstrated that periprosthetic BMD was well maintained in the proximal femur after THA with a short tapered-wedge stem and that stem anteversion affects periprosthetic BMD after THA.Wichtig Publishing Srl, 2016年05月, HIP International, 26(3) (3), 260 - 264, 英語[査読有り]研究論文（学術雑誌）
- The purpose of the present study was to: (1) investigate the variation of both acetabular and femoral component version in a large series of consecutive primary THA patients, and (2) to better define the associations of acetabular and femoral component alignment and clinical factors with subsequent hip dislocation in those patients. We analyzed CT scans of 1,555 consecutive primary THAs and measured version of the components. We also documented the frequency and direction of subsequent dislocation as well as femoral head size, posterior tissue repair, any history of previous hip surgery, and gender. The dislocation rate after THA was 3.22 %. The dislocation risk was 1.9 times higher if cup anteversion was not between 10A degrees and 30A degrees. Compared to hips that did not dislocate, those that experienced anterior dislocation had a significantly greater combined anteversion; those that dislocated posteriorly had a significantly smaller combined anteversion. Hips with previous rotational acetabular osteotomy or head size smaller than 28 mm correlated with an increased dislocation rate. The dislocation risk could be higher if cup anteversion was not between 10A degrees and 30A degrees. Greater combined anteversion could be a risk factor of anterior dislocation, and posterior dislocation could be more common in smaller combined anteversion.SPRINGER, 2016年04月, INTERNATIONAL ORTHOPAEDICS, 40(4) (4), 697 - 702, 英語[査読有り]研究論文（学術雑誌）
- Decoy receptor 3 (DcR3) competitively binds to three ligands, Fas ligand, lymphotoxin‑related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells and tumor necrosis factor‑like ligand 1A (TL1A), to prevent their effects. Recent studies have suggested that DcR3 directly affects cells as a ligand. Using a microarray assay, our group newly identified interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3. The present study demonstrated that IL‑12B mRNA expression was upregulated by DcR3‑Fc in RA‑FLS in a dose‑dependent manner, but not in OA‑FLS. IL‑12B p40 protein in RA‑FLS was increased when stimulated with DcR3‑Fc. Pre‑treatment with anti‑TL1A antibody suppressed the upregulation of IL‑12B mRNA in RA‑FLS stimulated with DcR3‑Fc. DcR3 mRNA expression in RA‑FLS was induced by IL‑23, but not by IL‑12. These results indicated that DcR3 may increase IL‑12 or IL‑23 by inducing IL‑12B p40 expression via membrane‑bound TL1A on RA‑FLS and that IL‑23 reciprocally induces DcR3 expression in RA‑FLS. DcR3 and IL‑23 may interact in a feedback loop that aggravates local inflammation in patients with RA.2016年04月, Molecular medicine reports, 13(4) (4), 3647 - 52, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2016年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 489 - 489, 日本語ミトコンドリア生合成の亢進はコラーゲン誘導性関節炎(CIA)マウスの関節破壊を抑制する[査読有り]
- (一社)日本リウマチ学会, 2016年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 626 - 626, 日本語関節リウマチ滑膜細胞において、decoy receptor 3はcentrosomal protein 70kDaの発現を抑制する[査読有り]
- Surgical Management of Irreducible Dislocation of the Peroneus Longus Tendon A Case ReportPeroneal tendon dislocation is often overlooked because the mechanism of injury is similar to that of lateral ligament sprains and the frequency of the disease is low. Therefore, it is difficult to treat peroneal tendon dislocation when diagnosed in the chronic state. Furthermore, because irreducible peroneal tendon dislocation has multiple causes, treatment is much harder. Herein, we present a rare case of irreducible dislocation caused by a complex pathogenesis. Surgical treatment yielded good results. Orthopedic surgeons should be aware of this issue and consider it in the preoperative simulation.AMER PODIATRIC MED ASSOC, 2016年03月, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 106(2) (2), 121 - 127, 英語[査読有り]研究論文（学術雑誌）
- 2016年03月, 日本整形外科学会雑誌, 90(3号) (3号), S947, 日本語人工足関節置換術前の変形性足関節症の病期は術後の成績に影響があるか[査読有り]研究論文（その他学術会議資料等）
- 2016年03月, 日本整形外科学会雑誌, 90(3号) (3号), S485, 日本語股関節鏡視下手術の適応と限界 単純X線学的指標から考察する股関節鏡視下手術の適応と限界研究論文（その他学術会議資料等）
- (一社)日本リウマチ学会, 2016年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 60回, 471 - 471, 日本語関節リウマチの病因・病態 リウマチ滑膜線維芽細胞におけるLIGHTによる遺伝子発現誘導の検討研究論文（その他学術会議資料等）
- 2016年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集 60回, 373, 日本語関節リウマチの手術 下肢 関節リウマチ患者に対する人工股関節全置換術後遅発性感染を引き起こす因子の検討[査読有り]研究論文（その他学術会議資料等）
- Objectives: To evaluate periprosthetic bone mineral density (BMD) changes around a cementless short tapered-wedge stem and determine correlations between BMD changes and various clinical factors, including daily activity, after total hip arthroplasty (THA) with a tapered-wedge stem. Methods: 65 patients underwent THA with a TriLock BPS stem. At baseline and at 6, 12, and 24 months post-operatively the BMD of the 7 Gruen zones were evaluated using dual-energy x-ray absorptiometry. Correlations were determined between BMD changes and clinical factors, including the Harris Hip Score, body mass index, University of California at Los Angeles (UCLA) activity rating score, age at surgery, and initial spine BMD. Radiographic parameters, including the proximal femoral geometry (Dorr Classification), canal filling ratio, canal flare index, and calcar-to-canal ratio were also assessed. Results: Minimal BMD changes were noted in the distal femur. However, significant BMD loss was noted in zone 7 at each time point. BMD loss was also noted in zone 1 at 6 and 12 months postoperatively, but BMD recovered after 18 months. Significant positive correlations were noted between BMD changes and the UCLA activity score in zones 1, 6, and 7. Additionally, negative correlations were noted between BMD changes and the preoperative lumbar BMD in zones 2 and 3. No correlations were noted between BMD changes and the radiographic parameters. Periprosthetic BMD was was virtually unchanged in the proximal femur, especially Gruen zone 1. Conclusions: Daily activity may reflect improvements in periprosthetic bone quality after THA; however, the use of this tapered-wedge stem is not recommended in patients with poor bone quality.WICHTIG PUBLISHING, 2016年03月, HIP INTERNATIONAL, 26(2) (2), 169 - 174, 英語[査読有り]研究論文（学術雑誌）
- 【はじめに，目的】近年，人工足関節全置換術（TAA）は，重度な変形性足関節症や関節リウマチにより高度に破壊された足関節に対する治療法として，選択施行されている。TAAの長期予後として，優れた除痛効果と関節可動域（ROM）の温存ならび改善に優れると報告されている。しかし，TAA術前から術後早期に身体機能変化について検討したものは見当たらない。また，術後の最大歩行速度（MWS）の低下は，手段的日常生活動作の低下や転倒のリスク因子であると報告されている。しかし，TAA術後のMWSに関連する因子についての報告はない。そこで，本研究の目的は，TAA術前と術後3ヶ月の身体機能の変化を比較検討するとともに，術後のMWSに関連する因子について検討することとした。【方法】対象は，2014年4月～2015年7月の期間に当院整形外科にて，TAAを施行された13名13足（男性3名，女性10名，年齢75.6±6.0歳）とした。13足のうち，変形性足関節症が12足，関節リウマチが1足であった。測定項目として，以下の項目を術前と術後3ヶ月で測定した。（1）他動ROM：足関節背屈および底屈のROMを測定した。（2）疼痛：歩行時の足関節の痛みについてVisual analog scale（以下VAS）を用いて数値化した。（3）歩行速度：10m歩行路の歩行時間を測定し，MWS（m/分）を算出した。統計解析として，術前と術後3ヶ月の各測定項目についてPaired t-testを用いて比較した。また術後3ヶ月において，MWSと背屈ROM，底屈ROM，VASの関連についてPearsonの相関分析を用いて検討した。すべての統計解析にはJMPver11.0を用い，有意水準は5%とした。【結果】背屈ROMは術前3.5±4.3°から術後7.3±3.9と有意に改善したが，底屈ROMは31.5±8.3から30.7±10.0°と有意な変化を示さなかった。また，VASは69.8±18.6から37.0.±20.7，MWSは54.4±20.0m/分から69.6±18.4m/分と有意な改善を認めた。術後3ヶ月において，MWSと背屈ROM（r=0.71），底屈ROM（r=0.56），VAS（r=0.56）とそれぞれ有意な相関関係が認められた。【結論】TAA術後3ヶ月では，術前に比べ背屈ROM，歩行時のVAS，MWSに有意な改善を認めた。術後3ヶ月におけるMWSに関連する因子として，背屈ROM，底屈ROM，VASに関連があることが示唆された。公益社団法人 日本理学療法士協会, 2016年, 理学療法学Supplement, 2015, 14 - 14, 日本語
- 【目的】人工股関節全置換術後感染（以下PJI）は長期治療を要する深刻な合併症である。PJIの鎮静化には抗菌薬治療と病巣掻爬・再置換等の外科的治療が必要であり，侵襲性の強い治療となる。近年，インプラントや抗菌薬の改良が進み，PJIの予防や診断，治療方法等に関する報告が散見される。一方で，PJI患者に対する理学療法や機能的予後に関して報告されたものは少ない。そこで本研究の目的は，当院にてPJI治療を施行し，自宅退院可能であった症例について検討することとした。【方法】対象は2012年4月～2015年10月当院にてPJIに対する治療をうけて自宅退院した10例10股のうち，永続的抜去術を施行された4例4股，PJI発症前より歩行困難であった1例を除外した5例5股（男性1例，女性4例：平均年齢69歳）とした。電子診療録より，PJI治療方法・最終人工股関節全置換術（以下THA）からPJI発症までの期間・基礎疾患・免荷期間・在院日数・発症前および退院時の歩行様式を後方視的に採取し検討した。【結果】人工股関節温存術（病巣掻爬＋抗菌薬治療）3例，二期的再置換術（人工関節抜去＋抗菌薬治療→再置換）2例であった。PJI発症までの期間は，3ヶ月以内の早期感染3例，1年以上の遅延感染2例，基礎疾患は関節リウマチ（以下RA）3例であった。全例において，発症前・退院時の歩行様式に変化なく退院可能であった。以下に6例の要約を示す。＜症例1，2＞順に76歳・85歳女性。基礎疾患にRAあり。PJI発症は順に術後4年・1か月半。温存術施行。2例ともに杖歩行で自宅退院。在院日数56日・67日であった。＜症例3＞33歳男性。特発性大腿骨頭壊死に対しTHA施行。術後1ヶ月でPJI発症し温存術施行。杖歩行で自宅退院。在院日数30日であった。＜症例4＞74歳女性。基礎疾患にRAあり。THA術後4年半で初回PJI発症，温存術で軽快するも1年半後に再燃，二期的再置換術施行。免荷期間61日。再置換術後3日より全荷重で歩行練習開始。術後21日で杖歩行自立，術後34日で自宅退院。在院日数96日であった。＜症例5＞77歳女性。基礎疾患なし。変形性股関節症に対し他院でTHA施行。術後13日でPJI発症。温存術で鎮静化せず当院転院，二期的再置換術施行。免荷期間101日。再置換術後3日より全荷重で歩行練習開始。術後35日で杖歩行自立，術後44日で自宅退院。PJI発症からの在院日数167日であった。【結論】本研究の結果より，PJIに対する温存術・二期的再置換術施行患者において，PJI治療後歩行様式が維持できる可能性が示唆された。温存術と異なり，長期免荷期間を要する二期的再置換術患者においては，免荷期間中の機能維持が理学療法の課題であると考えられる。今後は，PJIの外科的治療や免荷による下肢機能への影響を明らかにし，PJI患者に対するより効果的な理学療法の検討が望ましい。本研究結果は，今後増加すると予測されるPJI患者に対する理学療法への一助となると考えられる。公益社団法人 日本理学療法士協会, 2016年, 理学療法学Supplement, 2015, 134 - 134, 日本語
- Background: Femoroacetabular impingement (FAI) has been reported as a cause of hip pain in young patients and is suggested as the trigger for hip osteoarthritis (OA). The goal of this study was to quantify the metabolic profiles of articular tissues (cartilage, synovium, and labrum) harvested from patients with FAI and with end-stage OA. In addition, we sought to investigate the development of secondary OA in hips with FAI. Methods: Tissue samples were obtained from thirty hips undergoing arthroscopic surgery for FAI with or without labral tear and thirty hips undergoing total hip arthroplasty for OA. Quantitative real-time polymerase chain reaction (PCR) was performed to determine the gene expression of inflammatory cytokines and metabolic (anabolic and catabolic) enzymes. The differences in gene expression in articular tissues from the patients with FAI were also evaluated on the basis of clinical parameters (age range and alpha angle). Results: Themessenger RNA (mRNA) expression of the inflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-8 and of matrix metalloproteinase (MMP)-3 (a catabolic gene) in both the synovium and the labrum, and the expression of collagen type I alpha 1 (an anabolic gene) in the labrum, was higher in the samples from hips with OA than in those from hips with FAI (p < 0.05). In cartilage, however, the mRNA expression of the inflammatory cytokines and the catabolic genes MMP-13 and ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs-4) was higher in the FAI samples compared with the OA samples (p < 0.01). When the expression of inflammatory cytokines was evaluated among the three types of tissues within each disease group, the expression levels were the highest in cartilage within the FAI samples (p < 0.01). In FAI cartilage, we found higher gene expression of aggrecan (ACAN) and ADAMTS-4 in the samples from patients with larger alpha angles (>= 60 degrees) (p < 0.01). Conclusions: Our results indicate that the metabolic conditions of articular cartilage in FAI and OA are different and that the expression of genes associated with inflammation is greater in the articular cartilage of patients with FAI compared with the synovium and the labrum. The metabolic changes were heightened by mechanical impingement.JOURNAL BONE JOINT SURGERY, 2016年01月, JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 98(2) (2), 135 - 141, 英語[査読有り]研究論文（学術雑誌）
- 2015年11月, 日本バイオマテリアル学会大会予稿集 37回, 333, 日本語エイコサペンタエン酸は軟骨細胞の変性と変形性関節症の進行を抑制する[査読有り]研究論文（その他学術会議資料等）
- Introduction: Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle-related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle progression. However, it has been proposed that p21 is a regulator of transcription factor activity. In this study, we evaluated the role of p21 in response to biomechanical stress. Methods: Human chondrocytes were treated with p21-specific small interfering RNA (siRNA), and cyclic tensile strain was introduced in the presence or absence of a signal transducer and activator of transcription 3 (STAT3)-specific inhibitor. Further, we developed an in vivo OA model in a p21-knockout background for in vivo experiments. Results: The expression of matrix metalloproteinase (MMP13) mRNA increased in response to cyclic tensile strain following transfection with p21 siRNA, whereas the expression of aggrecan was decreased. Phospho-STAT3 and MMP-13 protein levels increased following downregulation of p21, and this was reversed by treatment with a STAT3 inhibitor. p21-deficient mice were susceptible to OA, and this was associated with increased STAT3 phosphorylation, elevated MMP-13 expression, and elevation of synovial inflammation. The expression of p21 mRNA was decreased and phosphorylation of STAT3 was elevated in human OA chondrocytes. Conclusions: The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therapeutic strategy for the treatment of OA.BIOMED CENTRAL LTD, 2015年11月, ARTHRITIS RESEARCH & THERAPY, 17, 314, 英語[査読有り]研究論文（学術雑誌）
- Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast‑like synoviocytes (RA‑FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate‑limiting enzyme in serotonin synthesis. The aim of the present study was to determine the specificity of the effects of DcR3 on TPH1 in RA‑FLS, and therefore determine whether DcR3 had the potential to modulate the pathogenesis of RA. The present study also aimed to compare the effects of DcR3 and inflammatory cytokines on the expression of TPH1 in RA‑FLS and osteoarthritis (OA)‑FLS. Primary cultured RA‑ or OA‑FLS were incubated with 1.0 µg/ml DcR3‑Fc protein or 1.0 µg/ml control immunoglobulin G (IgG)1 for 12 h, or with 1.0 ng/ml tumor necrosis factor (TNF)α, 1.0 ng/ml interleukin (IL)‑1β or serum‑free Opti‑MEM only, for 24 h. The relative mRNA expression levels of TPH1 were subsequently quantified using reverse transcription‑polymerase chain reaction. The expression of serotonin in RA or OA synovial tissue was detected using immunohistochemistry. The mRNA expression of TPH1 was observed in both RA‑ and OA‑FLS and was significantly decreased following treatment with DcR3 in the RA‑FLS, however, not in the OA‑FLS. The mRNA expression of TPH1 was significantly decreased following treatment with TNFα or IL‑1β in both the RA‑ and OA‑FLS. The expression of serotonin in the multi‑layered lining synovial cells of RA and the outer layer lining synovial cells of OA was detected using immunohistochemistry. The present study is the first, to the best of our knowledge, to demonstrate that the expression of TPH1 in FLS is downregulated by inflammatory cytokines, and that DcR3 suppressed the expression of TPH1 in RA‑FLS in a disease‑specific manner. These results suggested that synovial serotonin may be involved in the pathogenesis of RA, and that TPH1 and DcR3 may be potential therapeutic targets for the treatment of RA.2015年10月, Molecular medicine reports, 12(4) (4), 5191 - 6, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- In this article, we report two rheumatoid arthritis (RA) patients who developed rare, late onset infection after total hip arthroplasty (THA) following etanercept therapy. First patient was a 74-year-old female with RA. Treatment with etanercept was initiated three years after THA, and infection involving THA was observed two months after the initiation of etanercept. Patient was successfully treated by open debridement. Second patient was a 62-year-old female with RA. THA was performed, and infection involving THA was observed four years after the initiation of etanercept. This patient was also successfully treated by open debridement. However, when etanercept was reinitiated two years after open debridement, infection reoccurred. Immediately, open debridement was performed, prosthesis was removed, and antibiotic-impregnated, cement spacer was inserted. THA was repeated two months after open debridement. Late onset infection developing after THA following etanercept therapy in RA indicates that tumor necrosis factor-alpha blockers should be carefully administered in patients who have undergone THA.Turkish League Against Rheumatism (TLAR), 2015年09月, Archives of Rheumatology, 30(2) (2), 168 - 171, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本整形外科学会, 2015年09月, 日本整形外科学会雑誌, 89(8) (8), S1599 - S1599, 日本語TL1Aによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討[査読有り]研究論文（その他学術会議資料等）
- 2015年09月, 日本整形外科学会雑誌, 89(8号) (8号), S1535, 日本語p21欠損は炎症による変形性関節症を加速させる[査読有り]研究論文（その他学術会議資料等）
- 2015年09月, 日本整形外科学会雑誌, 89(8号) (8号), S1503, 日本語P21遺伝子はマウス筋損傷モデルにおいて細胞増殖および筋分化を調節する[査読有り]研究論文（その他学術会議資料等）
- 2015年08月, Osteoporosis Japan, 23(Suppl.1) (Suppl.1), 269, 日本語抗RANKL抗体製剤デノスマブ治療における骨粗鬆症患者の骨代謝マーカーおよびQOLの検討[査読有り]研究論文（その他学術会議資料等）
- 2015年07月, 日本骨代謝学会学術集会プログラム抄録集, (33回) (33回), 220, 日本語抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる[査読有り]研究論文（その他学術会議資料等）
- 2015年06月, JOSKAS, 40(4号) (4号), 131, 日本語足部インピンジメント症候群 AAIS、PAIS以外の足部インピンジメント症候群に対する足部内視鏡手術[査読有り]研究論文（その他学術会議資料等）
- Springer Tokyo, 2015年05月, Journal of Orthopaedic Science, 20(3) (3), 551 - 554, 英語[査読有り]研究論文（学術雑誌）
- 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S254, 日本語様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例研究論文（その他学術会議資料等）
- 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, 日本語抗RANKL抗体製剤デノスマブは骨粗鬆症患者のQOLを向上させる研究論文（その他学術会議資料等）
- 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S208, 日本語筋損傷後の治癒過程におけるp21の役割研究論文（その他学術会議資料等）
- 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S225, 日本語デノスマブによる骨粗鬆症治療の治療効果研究論文（その他学術会議資料等）
- 2015年05月, The Japanese Journal of Rehabilitation Medicine, 52(Suppl.) (Suppl.), S370, 日本語Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討研究論文（その他学術会議資料等）
- The potential relationship between cell cycle checkpoint control and tissue regeneration has been indicated. Despite considerable research being focused on the relationship between p21 and myogenesis, p21 function in skeletal muscle regeneration remains unclear. To clarify this, muscle injury model was recreated by intramuscular injection of bupivacaine hydrochloride in the soleus of p21 knockout (KO) mice and wild type (WT) mice. The mice were sacrificed at 3, 14, and 28 days post-operation. The results of hematoxylin-eosin staining and immunofluorescence of muscle membrane indicated that muscle regeneration was delayed in p21 KO mice. Cyclin D1 mRNA expression and both Ki-67 and PCNA immunohistochemistry suggested that p21 deficiency increased cell cycle and muscle cell proliferation. F4/80 immunohistochemistry also suggested the increase of immune response in p21 KO mice. On the other hand, both the mRNA expression and western blot analysis of MyoD, myogenin, and Pax7 indicated that muscular differentiation was delayed in p21KO mice. Considering these results, we confirmed that muscle injury causes an increase in cell proliferation. However, muscle differentiation in p21 KO mice was inhibited due to the low expression of muscular synthesis genes, leading to a delay in the muscular regeneration. Thus, we conclude that p21 plays an important role in the in vivo healing process in muscular injury.PUBLIC LIBRARY SCIENCE, 2015年05月, PLOS ONE, 10(5) (5), e0125765, 英語[査読有り]研究論文（学術雑誌）
- Background: Minimally invasive surgical approaches are widely used for total hip arthroplasty (THA). However, potential problems related to a reduced visual field during surgery, such as implant malposition, neurovascular injury, and poor implant fixation, have been reported. In these situations, a shorter stem is easier to insert in the femoral canal. To evaluate the accuracy of shorter stem orientation, we focused on the accuracy of stem orientation especially in short tapered wedge stems and evaluated the contribution factors of stem malalignment during mini-invasive total hip arthroplasty. Methods: One hundred ten hips that underwent THA with a Summit stem (58 hips) (DePuy, Warsaw, IN) as straight stem and TriLock stem (52 hips) (DePuy) as tapered wedge stem were enrolled in this study. For preoperative and postoperative evaluation, a CT scan of the pelvis and knee joint was obtained and was transferred to 3D template software. We compared the alignment of preoperative plan for stem anteversion/ valgus/anterior tilt angles and postoperative stem alignment, and the absolute error was defined as the surgical error. To clarify the factors contributing to the malalignment or surgical error, we evaluated postoperative stem alignment and several associated factors. Further, we compared the clinical parameters between two types of stems for analysis of the influence of stem type differences. Results: The mean absolute value of the alignment error (postoperative stem alignment-preoperative planning alignment) was not changed in the short tapered wedge and straight stems. Sex, age at operation, or original canal anteversion did not affect the accuracy of stem alignment. However, high body mass index (BMI) affected the accuracy of stem alignment. Clinical outcomes were not changed by the difference of stem types. Conclusion: The postoperative alignment of short tapered wedge stem was accurate, same as the straight stem during mini-invasive THA, but we need to pay attention when using this in obese patients.BIOMED CENTRAL LTD, 2015年04月, Journal of Orthopaedic Surgery and Research, 10, 52, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2015年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 59回, 480 - 480, 日本語Centrosomal protein 70kDaはdecoy receptor 3により関節リウマチ滑膜細胞に特異的に発現が抑制される[査読有り]
- (一社)日本リウマチ学会, 2015年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 59回, 480 - 480, 日本語TL1Aによるリウマチ滑膜線維芽細胞における遺伝子発現誘導の検討[査読有り]研究論文（その他学術会議資料等）
- (一社)日本リウマチ学会, 2015年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 59回, 479 - 479, 日本語RA滑膜細胞のミトコンドリア活性化は細胞増殖とMMP-3/RANKLの分泌を抑制する[査読有り]研究論文（その他学術会議資料等）
- Eicosapentaenoic acid (EPA) is an antioxidant and n-3 polyunsaturated fatty acid that reduces the production of inflammatory cytokines. We evaluated the role of EPA in chondrocyte apoptosis and degeneration. Normal human chondrocytes were treated with EPA and sodium nitroprusside (SNP). Expression of metalloproteinases (MMPs) was detected by real-time polymerase chain reaction (PCR) and that of apoptosis-related proteins was detected by western blotting. Chondrocyte apoptosis was detected by flow cytometry. C57BL/6J mice were used for the detection of MMP expression by immunohistochemistry and for investigation of chondrocyte apoptosis. EPA inhibited SNP-induced chondrocyte apoptosis, caspase 3 and poly(ADP-ribose) polymerase cleavage, phosphorylation of p38 MAPK and p53, and expression of MMP3 and MMP13. Intra-articular injection of EPA prevented the progression of osteoarthritis (OA) by inhibiting MMP13 expression and chondrocyte apoptosis. EPA treatment can control oxidative stress-induced OA progression, and thus may be a new approach for OA therapy. (c) 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:???-???, 2015.WILEY-BLACKWELL, 2015年03月, JOURNAL OF ORTHOPAEDIC RESEARCH, 33(3) (3), 359 - 365, 英語[査読有り]研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2015年03月, 中部日本整形外科災害外科学会雑誌, 58(春季学会) (春季学会), 178 - 178, 日本語DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する[査読有り]研究論文（その他学術会議資料等）
- Endochondral ossification at the growth plate is regulated by a number of factors and hormones. The cyclin-dependent kinase inhibitor p21 has been identified as a cell cycle regulator and its expression has been reported to be essential for endochondral ossification in vitro. However, to the best of our knowledge, the function of p21 in endochondral ossification has not been evaluated in vivo. Therefore, the aim of this study was to investigate the function of p21 in embryonic endochondral ossification in vivo. Wild-type (WT) and p21 knockout (KO) pregnant heterozygous mice were sacrificed on embryonic days E13.5, E15.5 and E18.5. Sagittal histological sections of the forearms of the embryos were collected and stained with Safranin 0 and 5-bromo-2'-deoxyuridine (BrdU). Additionally, the expression levels of cyclin D1, type II collagen, type X collagen, Sox9, and p16 were examined using immunohistochemistry, and the expression levels of p27 were examined using immunofluorescence. Safranin 0 staining revealed no structural change between the cartilage tissues of the WT and p21KO mice at any time point. Type II collagen was expressed ubiquitously, while type X collagen was only expressed in the hypertrophic zone of the cartilage tissues. No differences in the levels of Sox9 expression were observed between the two groups at any time point. The levels of cyclin D1 expression and BrdU uptake were higher in the E13.5 cartilage tissue compared with those observed in the embryonic cartilage tissue at subsequent time points. Expression of p16 and p27 was ubiquitous throughout the tissue sections. These results indicate that p21 may not be essential for embryonic endochondral ossification in articular cartilage of mice and that other signaling networks may compensate for p21 deletion.SPANDIDOS PUBL LTD, 2015年03月, MOLECULAR MEDICINE REPORTS, 11(3) (3), 1601 - 1608, 英語[査読有り]研究論文（学術雑誌）
- In this article, we report two rheumatoid arthritis (RA) patients who developed rare, late onset infection after total hip arthroplasty (THA) following etanercept therapy. First patient was a 74-year-old female with RA. Treatment with etanercept was initiated three years after THA, and infection involving THA was observed two months after the initiation of etanercept. Patient was successfully treated by open debridement. Second patient was a 62-year-old female with RA. THA was performed, and infection involving THA was observed four years after the initiation of etanercept. This patient was also successfully treated by open debridement. However, when etanercept was reinitiated two years after open debridement, infection reoccurred. Immediately, open debridement was performed, prosthesis was removed, and antibiotic-impregnated, cement spacer was inserted. THA was repeated two months after open debridement. Late onset infection developing after THA following etanercept therapy in RA indicates that tumor necrosis factor-alpha blockers should be carefully administered in patients who have undergone THA.TURKISH LEAGUE AGAINST RHEUMATISM, 2015年, ARCHIVES OF RHEUMATOLOGY, 30(2) (2), 168 - 171, 英語[査読有り]研究論文（学術雑誌）
- Surgical Management of the Peroneus Quartus Muscle for Bilateral Ankle Pain A Case ReportThe peroneus quartus muscle is an accessory muscle seen in the lateral compartment of the lower leg. Although the peroneus quartus muscle is asymptomatic in general, it sometimes becomes pathologic. We present the rare case of bilateral ankle pain with crepitation caused by the peroneus quartus muscle. Magnetic resonance imaging should be considered to assist with diagnosing this condition. Foot and ankle surgeons should consider it in the preoperative differential diagnosis when patients present with posterior ankle pain.AMER PODIATRIC MED ASSOC, 2015年01月, JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 105(1) (1), 85 - 91, 英語[査読有り]研究論文（学術雑誌）
- 2015年, Hip Joint, 4, 125 - 127, 日本語painDETECT による股関節疾患患者の神経障害性疼痛の実態調査研究論文（学術雑誌）
- Background: In daily clinical practice, it is essential to properly evaluate the postoperative sliding distance of various femoral head fixation devices (HFD) for trochanteric fractures. Although it is necessary to develop an accurate and reproducible method that is unaffected by inconsistent postoperative limb position on radiography, few studies have examined which method is optimal. Therefore, the purpose of this study is to prospectively compare the accuracy and reproducibility of our four original methods in the measurement of sliding distance of the HFD. Methods: Radiographs of plastic simulated bone implanted with Japanese proximal femoral nail antirotation were taken in five limb postures: neutral, flexion, minute internal rotation, greater external rotation, and flexion with external rotation. Orthopedic surgeons performed five measurements of the sliding distance of the HFD in each of the flowing four methods: nail axis reference (NAR), modified NAR, inner edge reference, and nail tip reference. We also assessed two clinical cases by using these methods and evaluated the intraclass correlation coefficients. Results: The measured values were consistent in the NAR method regardless of limb posture, with an even smaller error when using the modified NAR method. The standard deviation (SD) was high in the nail tip reference method and extremely low in the modified NAR method. In the two clinical cases, the SD was the lowest in the modified NAR method, similar to the results using plastic simulated bone. The intraclass correlation coefficients showed the highest value in the modified NAR method. Conclusions: We conclude that the modified NAR method should be the most recommended based on its accuracy, reproducibility, and usefulness.Korean Orthopaedic Association, 2015年, CiOS Clinics in Orthopedic Surgery, 7(2) (2), 152 - 157, 英語[査読有り]研究論文（学術雑誌）
- 2014年08月, 日本整形外科学会雑誌, 88(8号) (8号), S1576, 日本語筋損傷後の治癒過程におけるp21の役割[査読有り]研究論文（その他学術会議資料等）
- Purpose Femoroacetabular impingement is a new disease concept for hip disorders in young adults suggested as a major cause of primary hip osteoarthritis in Western countries. However, significant controversy exists regarding the prevalence and contribution of impingement deformities to osteoarthritis in Japan, owing to the higher prevalence of developmental dysplasia of the hip. Therefore, the aims of this study were to: (1) determine the prevalence of structural abnormalities associated with hip disorders in patients undergoing total hip replacement and (2) analyse the contribution of impingement deformities to osteoarthritis. Methods We analysed 250 patients from two different medical centres who underwent primary total hip replacement except those which were due to femoral head necrosis, posttraumatic osteoarthritis and systemic inflammatory disease. The average patient age at surgery was 64 years (range, 40-89 years), with 35 men and 215 women. Results Radiographic abnormality related to developmental dysplasia of the hip was associated with the majority of osteoarthritic hips (62 %). Hips with femoroacetabular impingement deformities were present within the cases categorized as unknown etiology. Cam impingement deformity was present in 22 % of unknown aetiology cases when cases with reactive osteophytes were excluded from all cam deformity cases (pistol grip deformity and aspherical femoral heads). Conclusions The prevalence of femoroacetabular impingement within primary osteoarthritis cases and gender predominance of impingement deformities are relatively similar to those reported previously in Western populations. This finding indicates that femoroacetabular impingement deformities are associated with osteoarthritis in the Japanese population, although it has a lower frequency among all hip failure patients.SPRINGER, 2014年08月, INTERNATIONAL ORTHOPAEDICS, 38(8) (8), 1609 - 1614, 英語[査読有り]研究論文（学術雑誌）
- 2014年07月, JOSKAS, 39(4号) (4号), 307, 日本語変形性足関節症の治療戦略:現状と未来 人工足関節置換術の現状と未来[査読有り]研究論文（その他学術会議資料等）
- Purpose The use of screws can enhance immediate cup fixation, but the influence of screw insertion on cup position has not previously been measured. The purpose of this study was to quantitatively evaluate the effect of intra-operative screw fixation on acetabular component alignment that has been inserted with the use of a navigation system. Methods We used a navigation system to measure cup alignment at the time of press-fit and after screw fixation in 144 hips undergoing total hip arthroplasty. We also compared those findings with factors measured from postoperative radiographs. Results The mean intra-operative change of cup position was 1.78 degrees for inclination and 1.81 degrees for anteversion. The intraoperative change of anteversion correlated with the number of screws. The intra-operative change of inclination also correlated with medial hip centre. Conclusion The insertion of screws can induce changes in cup alignment, especially when multiple screws are used or if a more medial hip centre is required for rigid acetabular fixation.SPRINGER, 2014年06月, INTERNATIONAL ORTHOPAEDICS, 38(6) (6), 1155 - 1158, 英語[査読有り]研究論文（学術雑誌）
- 2014年05月, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, 日本語有症性の両側第4腓骨筋腱に対する治療経験[査読有り]研究論文（その他学術会議資料等）
- 2014年05月, 理学療法学, 41(大会特別号2) (大会特別号2), 0125, 日本語ディシジョンツリー分析を用いた人工股関節全置換術後在院日数予測モデルの構築(第2報)[査読有り]研究論文（その他学術会議資料等）
- 2014年05月, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S305, 日本語G2ステム使用症例の短中期成績[査読有り]研究論文（その他学術会議資料等）
- Purpose The purposes of the present study were (1) to investigate the variation and accuracy of both acetabular and femoral component version on the axial computed tomographic (CT) images, and (2) to better define the associations between the components version and clinical factors. Methods We investigated acetabular and femoral component orientation in 1,411 primary total hip arthroplasties that had been performed without computer-assisted navigation. Version of the acetabular and femoral components was measured on the axial CT images. Results The component version was significantly greater than the native version in both acetabular and femoral version. There was a significant correlation between the stem and native femoral versions, but not between the acetabular component and native acetabular versions. Conclusion This study identifies several features that might help analyse the effect of pre-operative native acetabular and femoral version on the variation of component alignment.SPRINGER, 2014年05月, INTERNATIONAL ORTHOPAEDICS, 38(5) (5), 941 - 946, 英語[査読有り]研究論文（学術雑誌）
- 2014年05月, 中部日本整形外科災害外科学会雑誌, 57(3号) (3号), 677 - 678, 日本語Adverse reactions to metal debrisにより臼蓋コンポーネント周囲に巨大な骨欠損を生じた1例[査読有り]研究論文（その他学術会議資料等）
- 2014年03月, 日本整形外科学会雑誌, 88(2号) (2号), S417, 日本語足部インピンジメント症候群の診断と治療 足関節以外の足部インピンジメント症候群に対する足部内視鏡手術[査読有り]研究論文（その他学術会議資料等）
- 2014年03月, 日本整形外科学会雑誌, 88(2号) (2号), S476, 日本語青壮年期の股関節痛への対応 Femoroacetabular impingementに対する画像診断[査読有り]研究論文（その他学術会議資料等）
- 2014年03月, 日本整形外科学会雑誌, 88(2号) (2号), S463, 日本語人工股関節再置換術の創意工夫 Kerboull型プレートを用いた人工股関節再置換術の術後成績[査読有り]研究論文（その他学術会議資料等）
- 2014年03月, 日本整形外科学会雑誌, 88(2号) (2号), S473, 日本語人工股関節を適切な位置に設置するための術前・術後の評価 CT based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置精度における検討研究論文（その他学術会議資料等）
- (一社)日本リウマチ学会, 2014年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 58回, 674 - 674, 日本語IL-12Bはdecoy receptor 3により関節リウマチ滑膜細胞に特異的に発現誘導される[査読有り]研究論文（その他学術会議資料等）
- (一社)日本リウマチ学会, 2014年03月, 日本リウマチ学会総会・学術集会プログラム・抄録集, 58回, 674 - 674, 日本語DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する[査読有り]研究論文（その他学術会議資料等）
- Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) was identified as an important tumor suppressor gene. PTEN functions as a negative regulator of phosphoinositol-3-kinase (PI3K)-Akt and MEK/ERK signaling. The PI3K-Akt pathway is critical for cell survival, differentiation, and matrix synthesis. Oxidative stress is considered a critical factor in the onset and progression of osteoarthritis (OA). Therefore, we investigated the function of PTEN in OA chondrocytes under oxidative stress. Chondrocytes were treated with insulin-like growth factor-1 (IGF-1) and/or tert-butyl hydroperoxide (tBHP), which causes oxidative stress. The expression levels of type2 collagen (Col2a1) and aggrecan were analyzed by real-time PCR, and phosphorylation of Akt and ERK1/2 was analyzed by Western blotting. Chondrocytes were treated with PTEN-specific small interfering RNA (siRNA), as well as IGF-1 and/or tBHP. PTEN and IGF-1 expressions in OA chondrocytes were increased. The downregulation of PTEN expression increased the expression levels of Col2a1 and aggrecan, and increased proteoglycan synthesis under oxidative stress. Oxidative stress decreased the phosphorylation of Akt and increased that of ERK1/2. The downregulation of PTEN expression increased Akt phosphorylation, but did not increase that of ERK 1/2. Our results suggest that PTEN regulates matrix synthesis via the PI3K-Akt pathway under oxidative stress. (c) 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:231-237, 2014.WILEY-BLACKWELL, 2014年02月, JOURNAL OF ORTHOPAEDIC RESEARCH, 32(2) (2), 231 - 237, 英語[査読有り]研究論文（学術雑誌）
- Kashin-Beck disease (KBD) is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature therefore, KBD involves skeletal deformity and often results in osteoarthritis. Deficiency of selenium, high humic acid levels in water, and fungi on storage gains are considered the cause of KBD. The most frequently involved joints are ankles, knees, wrists, and elbows and symptoms are pain and limited motions of those joints. The main treatments for KBD are rehabilitation and osteotomy to correct the deformities because preventive treatment has not been established. In this report, we present a case of ankle osteoarthritis due to KBD and first describe arthroscopic ankle arthrodesis for treating osteoarthritis of KBD.Hindawi Limited, 2014年, Case Reports in Medicine, 2014, 931278, 英語[査読有り]研究論文（学術雑誌）
- Flexible hinge silicone implant with or without titanium grommets for arthroplasty of the first metatarsophalangeal jointPurpose. To review outcomes of 37 patients who underwent arthroplasty of the first metatarsophalangeal joint using flexible hinge silicone implants with or without titanium grommets. Methods. 36 women and one man (63 feet) underwent arthroplasty of the first metatarsophalangeal joint for rheumatoid arthritis (RA) using Swanson flexible hinge silicone toe implants with or without titanium grommets. 20 women (35 feet) aged 31 to 72 (mean, 52) years with Steinbrocker grade II (n=4), grade III (n=6), and grade IV (n=10) RA of the feet were treated with the implant without grommets, whereas 16 women and one man (28 feet) aged 48 to 73 (mean, 60) years with Steinbrocker grade III (n=4) and grade IV (n=13) RA of the feet were treated with the implant with grommets. Pain levels were self-rated. Degenerative changes and the presence of osteophytes or deformity were recorded, as were breakage or deformation of the implants, radiolucencies around the implant, implant loosening, silicone-induced synovitis, and sclerosis around the implant. Results. All patients reported pain relief from severe to mild or moderate. Respectively for the feet with and without grommets, the rates of implant deformation were 25% and 63% (p=0.031), whereas the rates of moderate-to-severe radiolucencies (>2 mm) were 4% and 34% (p =0.004). Sclerosis developed around the implant in all feet. Conclusion. Titanium grommets appear to protect the implant and improve clinical outcomes.HONG KONG ACAD MEDICINE PRESS, 2014年, JOURNAL OF ORTHOPAEDIC SURGERY, 22(1) (1), 42 - 45, 英語[査読有り]研究論文（学術雑誌）
- 2013年10月, 日本足の外科学会雑誌, 34(2号) (2号), S278, 日本語距骨に骨軟骨腫を生じた一例研究論文（その他学術会議資料等）
- 2013年10月, 日本足の外科学会雑誌, 34(2号) (2号), S326, 日本語カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例研究論文（その他学術会議資料等）
- 2013年10月, 日本足の外科学会雑誌, 34(2号) (2号), S187, 日本語TNK人工足関節置換術後の足関節可動域についての検討研究論文（その他学術会議資料等）
- Decoy receptor 3 (DcR3), a member of the tumor necrosis factor (TNF) receptor (TNFR) superfamily, lacks the transmembrane domain of conventional TNFRs in order to be a secreted protein. DcR3 competitively binds and inhibits members of the TNF family, including Fas ligand (FasL), LIGHT and TNF-like ligand 1A (TL1A). We previously reported that TNFα-induced DcR3 overexpression in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) protects cells from Fas-induced apoptosis. Previous studies have suggested that DcR3 acting as a ligand directly induces the differentiation of macrophages into osteoclasts. Furthermore, we reported that DcR3 induces very late antigen-4 (VLA--4) expression in THP-1 macrophages, inhibiting cycloheximide-induced apoptosis and that DcR3 binds to membrane-bound TL1A expressed on RA-FLS, resulting in the negative regulation of cell proliferation induced by inflammatory cytokines. In the current study, we used cDNA microarray to search for genes in RA-FLS whose expression was regulated by the ligation of DcR3. The experiments revealed the expression profiles of genes in RA-FLS regulated by DcR3. The profiles showed that among the 100 genes most significantly regulated by DcR3, 45 were upregulated and 55 were downregulated. The upregulated genes were associated with protein complex assembly, cell motility, regulation of transcription, cellular protein catabolic processes, cell membrane, nucleotide binding and glycosylation. The downregulated genes were associated with transcription regulator activity, RNA biosynthetic processes, cytoskeleton, zinc finger region, protein complex assembly, phosphate metabolic processes, mitochondrion, ion transport, nucleotide binding and cell fractionation. Further study of the genes detected in the current study may provide insight into the pathogenesis and treatment of rheumatoid arthritis by DcR3-TL1A signaling.2013年10月, International journal of molecular medicine, 32(4) (4), 910 - 6, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- Most of computer-assisted planning systems need to determine the anatomical axis based on the anterior pelvic plane (APP). We analysed that our new system is more reproducible for determination of APP than previous methods. A pelvic model bone and two subjects suffering from hip osteoarthritis were evaluated. Multidetector-row computed tomography (MDCT) images were scanned with various rotations by MDCT scanner. The pelvic rotation was calibrated using silhouette images. APP was determined by an optimisation technique. The values of variation of APP caused by pelvic rotation were analysed with statistical analysis. APP determination with calibration and optimisation was most reproducible.The values of variance of APP were within 0.05 degrees in model bone and 0.2 degrees even in patient pelvis. Furthermore, the values of variance of APP with calibration/optimisation were significantly lower in comparison without calibration/optimisation. Both calibration and optimisation are actually required for determination of APP. This system could contribute to the evaluation of hip joint kinematics and computer-assisted surgery.TAYLOR & FRANCIS LTD, 2013年09月, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 16(9) (9), 937 - 942, 英語[査読有り]研究論文（学術雑誌）
- (一社)中部日本整形外科災害外科学会, 2013年09月, 中部日本整形外科災害外科学会雑誌, 56(秋季学会) (秋季学会), 152 - 152, 日本語全身静脈血サンプリングが診断に有用であった右手関節軟部腫瘍による腫瘍性骨軟化症の1例研究論文（その他学術会議資料等）
- 2013年08月, International Journal of Orthopaedic and Trauma Nursing, 17(3) (3), 168, 英語研究論文（学術雑誌）
- 2013年08月, 日本整形外科学会雑誌, 87(8号) (8号), S1321, 日本語ヒト軟骨細胞においてPTENは酸化ストレス下に基質の産生を調整する研究論文（その他学術会議資料等）
- 2013年08月, 日本整形外科学会雑誌, 87(8号) (8号), S1322, 日本語エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する研究論文（その他学術会議資料等）
- Purpose: Implant dislocations are often caused by implant or bone impingement, and less impingement is critical to prevent dislocations. The aim of this study was to clarify the effect of the femoral offset in avoiding component or bony impingement after total hip arthroplasty (THA). Methods: Seventy-eight patients underwent THA with a Pinnacle cup and Summit stem (DePuy). Intraoperative kinematic analysis was performed with a navigation system, which was used to obtain intraoperative range of motion (ROM) measurements during trial insertion of stems of two different offset lengths with the same head size. Further, ROM was also measured after actual component insertion. Results: Maximal ROM was independent of the femoral offset of the stem in each patient. However, the range of external rotation was significantly greater in patients with a greater femoral offset. Conclusions: The Summit stem has enough offset length to avoid implant/bone impingement, even when the standard offset stem is used. Nevertheless, selection of the offset stem should be performed carefully to prevent offset complications. © 2013 Springer-Verlag Berlin Heidelberg.2013年07月, International Orthopaedics, 37(7) (7), 1233 - 1237, 英語[査読有り]研究論文（学術雑誌）
- 2013年06月, JOSKAS, 38(4号) (4号), 218, 日本語カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例研究論文（その他学術会議資料等）
- 2013年06月, JOSKAS, 38(4号) (4号), 422, 日本語Femoroacetabular Impingementにおける関節軟骨に対するT1rho MRIの診断意義[査読有り]研究論文（その他学術会議資料等）
- Purpose: Accurate orientation of acetabular and femoral components are important during THA. However, no study has assessed the use of the CT-based fluoro-matched navigation system during THA. Therefore, we have evaluated the accuracy of stem orientation by CT-based fluoro-matched navigation. Methods: The accuracy of stem orientation by CT-based fluoro-matched navigation was assessed by postoperative CT data. Furthermore, we compared the postoperative stem orientation with the intraoperative registration errors. Results: The average antetorsion error of the stem (navigation records - postoperative CT) was -0.5 ± 5.2. The stem valgus error was 0.4 ± 2.7. The accuracy of the navigation record for the orientation of the stem valgus was dependent on the intraoperative registration errors. Conclusions: The clinical accuracy of CT-based fluoro-matched navigation is adequate for stem alignment orientation, and the intraoperative verification of registration errors is valuable for checking the accuracy of stem orientation by navigation. © 2013 Springer-Verlag Berlin Heidelberg.2013年06月, International Orthopaedics, 37(6) (6), 1063 - 1068, 英語[査読有り]研究論文（学術雑誌）
- This study evaluated the effectiveness of using video information as a tool in postoperative total hip arthroplasty (THA) patients to help regain their daily activity after discharge. In order to assess patients' activities of daily living after discharge from hospital, we asked their families to take video footage of their activities using a video camera and to send us the video. We investigated a new postoperative educational intervention in which healthcare professionals provided education and instructions to the patients on the basis of the video footage. Patients were assigned randomly to either an intervention group (2 men, 9 women mean age, 60.7±9.4 years) or a control group (3 men, 10 women mean age, 59.5±13.8 years). Four self-reported questionnaires were used to compare the intervention and control groups: the Oxford hip score, a pain scale, a survey of exercise self-efficacy and the SF-8 health survey. There was a significant improvement in Oxford hip score, exercise self-efficacy and SF-8 physical component summary in the intervention group compared to the control group. This suggests that our educational intervention with video information method improved self-efficacy and activities of daily living in THA patients. © 2013 Elsevier Ltd.2013年05月, International Journal of Orthopaedic and Trauma Nursing, 17(2) (2), 91 - 98, 英語[査読有り]研究論文（学術雑誌）
- Hip range of motion (ROM) may be an important preoperative variable, however, measurement of hip ROM can be affected by various factors. V The purposes of this study were to compare conventional preoperative ROM measurements with those measurements obtained under general anaesthesia, and to better define the associations between preoperative hip ROM, and demographic, functional, and diagnostic variables. Conventional preoperative hip ROM and ROM under general anaesthesia were prospectively measured in 471 hips. Harris pain score, the Crowe classification, and the diagnosis were also investigated. The hip ROM in all directions under general anaesthesia was significantly greater than conventional preoperative hip ROM. There were correlations between conventional preoperative hip ROM and the Harris hip pain score. Hip ROM with Crowe type I deformity under anaesthesia was significantly greater than in hips with type II, III or IV. ROM under anaesthesia of osteonecrosis hips was significantly greater than osteoarthritis and dislocated hips Conventional preoperative ROM in men was greater in flexion and external rotation compared to women. Internal rotation motion in women in both conventional preoperative ROM and ROM under anaesthesia was greater than in men. Hip pain, Crowe classification and diagnosis could influence preoperative hip ROM. Measurement of hip ROM under general anaesthesia could better reflect true ROM compared to measurement without anaesthesia.WICHTIG EDITORE, 2013年05月, HIP INTERNATIONAL, 23(3) (3), 298 - 302, 英語[査読有り]研究論文（学術雑誌）
- 2013年03月, 日本整形外科学会雑誌, 87(2号) (2号), S226, 日本語変形性股関節症に対するChiari骨盤骨切り術の長期成績[査読有り]研究論文（その他学術会議資料等）
- 2013年03月, 日本整形外科学会雑誌, 87(2号) (2号), S427, 日本語人工股関節置換術後でのエドキサバン投与の有用性と安全性[査読有り]研究論文（その他学術会議資料等）
- RESULTS: Of the 16 hips treated with a transverse subtrochanteric shortening femoral osteotomy, 2, 2, and 12 were Crowe types II, III, and IV, respectively. In these 16 hips, hip flexion was high in 10 (mean, 86º) and low in 6 (mean, 36º). Leg-length change was significantly greater in the high than low flexion groups (31 vs. 13 mm, p< 0.01). In the 76 hips without osteotomy, hip flexion was high in 54 (mean, 85º) and low in 22 (mean, 40º). Leg-length change was significantly greater in the high than low flexion groups (25 vs. 19 mm, p=0.016). Preoperative hip flexion under general anaesthesia correlated with leg-length change in hips with osteotomy (r=0.850, p=0.0002) and without osteotomy (r=0.267, p=0.019). CONCLUSION: Preoperative hip flexion measured under general anaesthesia may predict leg-length change after THA. PURPOSE: To measure preoperative hip flexion under general anaesthesia in patients with developmental dysplasia of the hip and analyse its correlation with leg-length change. METHODS: 79 women and 6 men aged 27 to 82 (mean, 59) years underwent 92 total hip arthroplasties for severe developmental dysplasia of the hip of Crowe types II (n=60), III (n=17), and IV (n=15). All such patients had severe pain and/or considerable difficulty in walking and performing daily activities. 16 of the hips were treated with transverse subtrochanteric shortening osteotomy, whereas the remaining 76 had no femoral osteotomy. Preoperative passive hip flexion was measured under general anaesthesia with a goniometer by a single investigator. Its mean value in patients with Crowe type-III deformity was 60.3º. Therefore, > 60º of flexion was defined as high. Postoperative leg-length change was measured radiographically. The distraction of the greater trochanter was equal to the leg-length change in patients treated without femoral osteotomy, whereas leg-length change was calculated by subtracting the amount of resection of the femur from the distraction of the greater trochanter in patients treated with femoral osteotomy.2012年12月, Journal of orthopaedic surgery (Hong Kong), 20(3) (3), 327 - 330, 英語研究論文（学術雑誌）
- Purpose Several studies have reported a risk of dislocation in obese patients after total hip arthroplasty. In this study, we evaluated the interaction between obesity and dislocation by kinematic analysis using a navigation system. Methods The intraoperative range of motion (ROM) and postoperative impingement-free ROM were measured in 38 patients, and we compared the impingement-free ROM in obese and non obese patients. Results The postoperatively simulated ROM was similar in the obese and non obese groups. The intraoperative ROM was smaller in the obese group. The difference values between the intraoperative ROM and postoperatively simulated ROM were larger in the obese group. These results indicate that obese patients have less ROM following primary total hip arthroplasty even when the implant positioning is performed correctly. Conclusions Dislocations are multifactorial problems including soft tissue impingement. Therefore, the risk of dislocation caused by soft tissue impingement in obese patients may be increased.SPRINGER, 2012年12月, INTERNATIONAL ORTHOPAEDICS, 36(12) (12), 2419 - 2423, 英語[査読有り]研究論文（学術雑誌）
- Objective: The p53 tumor-suppressor protein p53R2 is activated in response to various stressors that act on cell signaling. When DNA is damaged, phosphorylation of p53 at its Ser 15 residue induces p53R2 production. The role of p53R2 in chondrocytes remains poorly understood. In this study, we evaluated in chondrocytes, p53R2 expression and its regulation in response to mechanical stress. Furthermore, we investigated the function of p53R2 in relation to mechanotransduction. Methods: Osteoarthritis (OA) cartilage obtained from total knee replacements and normal cartilage obtained from femoral neck fractures was used to measure p53R2 expression by using immunohistochemistry, western blotting, and real-time polymerase chain reaction (PCR). The OA chondrocytes were subjected to a high magnitude of cyclical tensile strain by using an FX-2000 Flexercell system. Next, sulfated glycosaminoglycan (sGAG) production was quantified in these cells. Protein expression of p53R2, and phosphorylation of Akt, p38MAPK, ERK1/2, and JNK was also detected using western blotting. Moreover, Akt phosphorylation was detected after transfecting the cells with p53R2-specific small interfering RNA (siRNA). Results: Expression of p53R2 was significantly increased in OA chondrocytes and in chondrocytes after applying 5% tensile strain to the cells. However. Akt phosphorylation was down-regulated in OA chondrocytes after the strain, and was up-regulated after transfection of p53R2. sGAG protein as well as collagen type II and aggrecan mRNA was increased following transfection of p53R2-specific siRNA after 5% tensile strain. Conclusions: p53R2 could regulate matrix synthesis via Akt phosphorylation during chondrocyte mechanotransduction. Down-regulation of p53R2 may be a new therapeutic approach in OA therapy. (C) 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.ELSEVIER SCI LTD, 2012年12月, OSTEOARTHRITIS AND CARTILAGE, 20(12) (12), 1603 - 1609, 英語[査読有り]研究論文（学術雑誌）
- Total hip arthroplasty (THA) is a well established treatment for arthrosis of the hip, however many problems remain which have not yet been resolved, including component loosening and infection. Therefore, surgeons hesitate to perform THA in younger patients showing early signs of the disease. Intertrochanteric varus osteotomy was developed for osteoarthrosis with coxa valga. This procedure has been commonly used in patients with dysplastic hips. However, femoral head coverage is not sufficiently improved by this procedure. In order to overcome the disadvantages of this procedure, since 1972 we performed intertrochanteric varus osteotomy simultaneously combined with acetabuloplasty for the treatment of osteoarthrosis secondary to dysplasia. Between 1969 and 1994, we performed 104 intertrochanteric varus osteotomies for prearthrosis and early stage arthrosis of the hip due to acetabular dysplasia in 84 patients. In this study, we reviewed these patients clinically and radiographically, over 15 years. The intertrochanteric varus osteotomy alone was employed in 38 hips (varus group). Combined intertrochanteric varus osteotomy and acetabuloplasty was employed in 63 hips (combined group). The average Harris hip score at the latest follow-up in the combined group significantly higher than that in the 'varus' group. Postoperative centre-edge angle and age at operation were correlated with the Harris hip score at the most recent follow-up. The results of the present study indicate that this combined intertrochanteric varus osteotomy and acetabuloplasty for dysplastic hip should be considered in young patients when the disease is at an early stage.WICHTIG EDITORE, 2012年11月, HIP INTERNATIONAL, 22(6) (6), 628 - 632, 英語[査読有り]研究論文（学術雑誌）
- 金原出版, 2012年10月, 整形・災害外科, 55(11号) (11号), 1355 - 1364, 日本語【骨・関節のバイオメカニクス-最近の進歩】 人工股関節動作解析を目的としたイメージマッチングと骨盤座標系の自動決定法[査読有り]研究論文（学術雑誌）
- 2012年08月, 日本整形外科学会雑誌, 86(8号) (8号), S1219, 日本語軟骨細胞におけるAktのリン酸化はメカニカルストレスで生じるp53R2により制御される[査読有り]研究論文（その他学術会議資料等）
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1110 - S1110, 日本語関節リウマチ滑膜細胞におけるDcR3による遺伝子発現誘導の検討[査読有り]研究論文（その他学術会議資料等）
- 2012年08月, 日本整形外科学会雑誌, 86(8号) (8号), S1332, 日本語ヒト軟骨細胞においてPTENはtype II collagenの発現を制御する[査読有り]研究論文（その他学術会議資料等）
- Periprosthetic bone loss around the femoral stem is frequently found after total hip arthroplasty. We have shown that periprosthetic bone mineral density (BMD) loss using the triple tapered stem is consistently much less in comparison with the straight type component. In this study, we compared periprosthetic BMD change with clinical factors. Postoperative dual-energy X-ray absorptiometry was evaluated at follow-up. BMD was determined based on seven Gruen zones. We further compared BMD with clinical examination: body mass index (BMI), age, Harris hip score (HHS) or University of California at Los Angeles (UCLA) activity rating score. Periprosthetic BMD loss of the triple tapered stem was maintained. Especially, BMD in Gruen zone 1 which was maintained at 96% in comparison with the straight tapered stem. We compared the BMD change with clinical factors. There is no correlation between BMD and BMI, age or HHS. However, we found significant correlation between BMD and UCLA activity rating score in Gruen zones 1 and 2 of the triple tapered stem. Further, the correlation coefficient was increased at 48 months in comparison with 24 months. The cementless triple tapered stem maintains periprosthetic bone mineral density. Activity may reflect improving periprosthetic bone quality after THA using a triple tapered stem.SPRINGER, 2012年06月, INTERNATIONAL ORTHOPAEDICS, 36(6) (6), 1137 - 1142, 英語[査読有り]研究論文（学術雑誌）
- Primary total hip arthroplasties were performed in 70 hips for the treatment of Crowe type IV developmental dysplasia of the hip. The patients were subdivided into 2 groups with or without iliofemoral osteoarthritis. Leg length change was measured radiographically. Preoperative hip motion was reviewed from medical records and defined as either higher or lower motion groups. The leg length change in patients without iliofemoral osteoarthritis was significantly greater than that in patients with iliofemoral osteoarthritis, and the higher hip motion group had greater leg length change in total hip arthroplasty than the lower motion group. The current study identifies several features that might help predict leg length change during the preoperative planning of total hip arthroplasty for Crowe type IV developmental hip dysplasia.CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS, 2012年06月, JOURNAL OF ARTHROPLASTY, 27(6) (6), 1019 - 1022, 英語[査読有り]研究論文（学術雑誌）
- 2012年05月, 中部日本整形外科災害外科学会雑誌, 55(3号) (3号), 669 - 670, 日本語両側THA後、両側恥骨・腸骨にinsufficiency fractureを呈した1例研究論文（その他学術会議資料等）
- 2012年04月, 理学療法学, 39(Suppl.2) (Suppl.2), 0912, 日本語人工股関節全置換術後患者はいつまで杖を使用するべきか 体幹加速度リサージュ波形用いた歩行解析[査読有り]研究論文（その他学術会議資料等）
- 2012年03月, 日本整形外科学会雑誌, 86(3号) (3号), S353, 日本語Kerboull型プレートを用いた人工股関節再置換術の術後成績[査読有り]研究論文（その他学術会議資料等）
- Insufficiency fracture is of the stress fractures and is caused by repetitive stress on fragile bone. Insufficiency fractures of pubic rami are rare occurrences in association with total hip arthroplasty (THA). Postoperative stress fractures occur due to increase of patients activity following years of disability. The physician should consider the possibility of a pelvic insufficiency fracture in patients with RA after THA, if the patients present with groin pain. We demonstrate here the first case of bilateral insufficiency fracture of pubic rami and iliac bone following THA. © Copyright 2012 Shinya Hayashi et al.Hindawi Limited, 2012年, Case Reports in Medicine, 2012, 170736, 英語[査読有り]研究論文（学術雑誌）
- Fibroblast growth factor 23 (FGF23) was recently identified as an important factor involved in the development of hypophosphatemic rickets and osteomalacia. We experienced a rare case of acute prosthesis migration after hemihip arthroplasty due to FGF23-induced tumor. The patient underwent femoral head replacement because of femoral neck fracture, but prosthesis migration was occurred at 1 week after operation. The patient took various examinations, and FGF23-induced tumor was found in his right wrist. The tumor was resected, and he underwent total hip arthroplasty 8 month later. Finally, he was able to obtain free gait without pain.2012年, Case reports in medicine, 2012, 503956 - 503956, 英語, 国際誌[査読有り]研究論文（大学，研究機関等紀要）
- 2012年01月, 日本骨・関節感染症学会雑誌, 25, 96 - 99, 日本語人工骨頭置換術後感染に伴う後腹膜膿瘍の1例[査読有り]研究論文（学術雑誌）
- Predicting leg-length change after total hip arthroplasty by measuring preoperative hip flexion under general anaesthesiaPurpose. To measure preoperative hip flexion under general anaesthesia in patients with developmental dysplasia of the hip and analyse its correlation with leg-length change. Methods. 79 women and 6 men aged 27 to 82 (mean, 59) years underwent 92 total hip arthroplasties for severe developmental dysplasia of the hip of Crowe types II (n=60), III (n=17), and IV (n=15). All such patients had severe pain and/or considerable difficulty in walking and performing daily activities. 16 of the hips were treated with transverse subtrochanteric shortening osteotomy, whereas the remaining 76 had no femoral osteotomy. Preoperative passive hip flexion was measured under general anaesthesia with a goniometer by a single investigator. Its mean value in patients with Crowe type-III deformity was 60.3 degrees. Therefore, >60 degrees of flexion was defined as high. Postoperative leg-length change was measured radiographically. The distraction of the greater trochanter was equal to the leg-length change in patients treated without femoral osteotomy, whereas leg-length change was calculated by subtracting the amount of resection of the femur from the distraction of the greater trochanter in patients treated with femoral osteotomy. Results. Of the 16 hips treated with a transverse subtrochanteric shortening femoral osteotomy, 2, 2, and 12 were Crowe types II, III, and IV, respectively. In these 16 hips, hip flexion was high in 10 (mean, 86 degrees) and low in 6 (mean, 36 degrees). Leg-length change was significantly greater in the high than low flexion groups (31 vs. 13 mm, p<0.01). In the 76 hips without osteotomy, hip flexion was high in 54 (mean, 85 degrees) and low in 22 (mean, 40 degrees). Leg-length change was significantly greater in the high than low flexion groups (25 vs. 19 mm, p=0.016). Preoperative hip flexion under general anaesthesia correlated with leg-length change in hips with osteotomy (r=0.850, p=0.0002) and without osteotomy (r=0.267, p=0.019). Conclusion. Preoperative hip flexion measured under general anaesthesia may predict leg-length change after THA.HONG KONG ACAD MEDICINE PRESS, 2012年, JOURNAL OF ORTHOPAEDIC SURGERY, 20(3) (3), 327 - 330, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本関節病学会, 2011年10月, 日本関節病学会誌, 30(3) (3), 414 - 414, 日本語両手同時撮像用架台と心臓用コイル用いた手部造影MRIのRA診断への有用性の検討[査読有り]
- Rationale: Despite preclinical success in regenerating and revascularizing the infarcted heart using angiogenic growth factors or bone marrow (BM) cells, recent clinical trials have revealed less benefit from these therapies than expected. Objective: We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a VEGF-related angiogenic growth factor, with progenitor-mobilizing activity. Methods and Results: Myocardial PlGF gene therapy improves cardiac performance after myocardial infarction, by inducing cardiac repair and reparative myoangiogenesis, via upregulation of paracrine anti-apoptotic and angiogenic factors. In addition, PlGF therapy stimulated Sca-1 +/Lin - (SL) BM progenitor proliferation, enhanced their mobilization into peripheral blood, and promoted their recruitment into the peri-infarct borders. Moreover, PlGF enhanced endothelial progenitor colony formation of BM-derived SL cells, and induced a phenotypic switch of BM-SL cells, recruited in the infarct, to the endothelial, smooth muscle and cardiomyocyte lineage. Conclusions: Such pleiotropic effects of PlGF on cardiac repair and regeneration offer novel opportunities in the treatment of ischemic heart disease. © 2011 Iwasaki et al.2011年09月, PLoS ONE, 6(9) (9), e24872, 英語[査読有り]研究論文（学術雑誌）
- Decoy receptor 3 (DcR3), a member of the tumour necrosis factor receptor (TNFR) superfamily, lacks the transmembrane domain of conventional TNFRs in order to be a secreted protein. DcR3 competitively binds and inhibits members of the TNF family, including Fas ligand (FasL), LIGHT and TL1A. We previously reported that TNF alpha-induced DcR3 overexpression in rheumatoid synovial fibroblasts (RA-FLS) protects the cells from Fas-induced apoptosis and that DcR3 induces VLA-4 expression in THP-1 macrophages to inhibit cycloheximide-induced apoptosis. Meanwhile, recent studies have suggested that DcR3 acting as a ligand directly induces the differentiation of macrophages to osteoclasts. Therefore, in the present study, we analyzed the direct effects of DcR3 as a ligand in RA-FLS. The experiments showed that DcR3 binds to TL1A expressed in RA-FLS resulting in the negative regulation of cell proliferation induced by inflammatory cytokines. DcR3-TL1A signalling may be involved in the pathogenesis of rheumatoid arthritis (RA).SPANDIDOS PUBL LTD, 2011年09月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 28(3) (3), 423 - 427, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本整形外科学会, 2011年08月, 日本整形外科学会雑誌, 85(8) (8), S1297 - S1297, 日本語関節リウマチ滑膜細胞におけるTL1AとDcR3の発現に関する検討[査読有り]
- Introduction: Decoy receptor 3 (DcR3), a soluble receptor belonging to the tumor necrosis factor (TNF) receptor superfamily, competitively binds and inhibits the TNF family including Fas-ligand (Fas-L), lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T-cells (LIGHT) and TNF-like ligand 1A (TL1A). In this study, we investigated the functions of DcR3 on osteoarthritis (OA) chondrocytes. Methods: Expressions of DcR3 in chondrocytes were measured by realtime Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR). Expression of DcR3 in sera and joint fluids was measured by enzyme-linked immunosorbent assay (ELISA). Chondrocytes were incubated with DcR3-Fc chimera protein (DcR3-Fc) before induction of apoptosis by Fas-L and apoptosis was detected with terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labelling labeling (TUNEL) staining and Western blotting of caspase 8 and poly (ADP-ribose) polymerase (PARP). Chondrocytes were incubated with DcR3-Fc and the proliferation was analyzed by 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST) assay. Phosphorylation of Extracellular Signal-Regulated Kinase (ERK), P38 mitogen-activated protein kinase (MAPK) and Jun N-terminal Kinase (JNK) in chondrocytes was measured by Western blotting after incubation with DcR3-Fc, Mitogen-activated protein kinase kinase (MEK1/2) inhibitor, or P38 MAPK inhibitor. Chondrocytes were treated with DcR3-Fc after pre-incubation with blocking antibody of Fas-L, LIGHT and TL1A, and proliferation or phosphorylation of ERK was analyzed. Results: DcR3 was expressed in OA and normal chondrocytes. DcR3-Fc protects chondrocytes from Fas-induced apoptosis. DcR3-Fc increased chondrocytes proliferation and induced the phosphorylation of ERK specifically. DcR3-induced chondrocytes proliferation was inhibited by pre-incubation of PD098059 or blocking Fas-L antibody. DcR3 increased chondrocytes proliferation in OA chondrocytes, but did not in normal. Conclusion: DcR3 regulates the proliferation of OA chondrocytes via ERK signaling and Fas-induced apoptosis. (C) 2011 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.ELSEVIER SCI LTD, 2011年07月, OSTEOARTHRITIS AND CARTILAGE, 19(7) (7), 903 - 910, 英語[査読有り]研究論文（学術雑誌）
- (一社)日本リウマチ学会, 2011年06月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 426 - 426, 日本語関節リウマチの関節外病変 Fスケールを用いた関節リウマチ患者の胃食道逆流症(GERD)に関する検討[査読有り]
- (一社)日本リウマチ学会, 2011年06月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 490 - 490, 日本語DcR3はTL1Aを介してサイトカインによるリウマチ滑膜細胞の増殖を抑制する[査読有り]
- (一社)日本リウマチ学会, 2011年06月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 55回・20回, 491 - 491, 日本語関節リウマチ滑膜細胞におけるTL1AとDcR3の発現に関する検討[査読有り]
- 金原出版(株), 2011年05月, 整形・災害外科, 54(6) (6), 672 - 673, 日本語分子レベルからみた整形外科疾患(シリーズVIII) DcR3と関節リウマチ[査読有り]
- Periprosthetic bone loss is a well documented phenomenon after cementless total hip arthroplasty. We compared the bone mineral density (BMD) in 33 patients using the three dimension taper shape stem and 13 patients with a straight component with a distal taper. Postoperative follow-up was evaluated by dual-energy X-ray absorptiometry. BMD was recorded in seven Gruen zones. BMD was correlated with clinical examination, Harris Hip Score (HHS), Body Mass Index (BMI) and age. Clinical assessment took place at 12 months post operation. Periprosthetic BMD loss using the three dimensional straight tapered stem was consistently much less in comparison with the straight type component with a distal tapered design stem. BMD in Gruen zone 1 was maintained. There was no correlation between periprosthetic bone mineral density and clinical factors. © 2011 Wichtig Editore.2011年03月, HIP International, 21(2) (2), 163 - 167, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本整形外科学会, 2011年03月, 日本整形外科学会雑誌, 85(3) (3), S746 - S746, 日本語両手同時撮影コイルを用いたMRIによる関節リウマチ滑膜炎の定量化の検討[査読有り]
- Activation of p38 MAPK has been associated with a stress response and with apoptotic processes. However, the function of p38 MAPK in chondrocytes is not clearly understood. In this study, we analyzed the expression of p38 MAPK in chondrocytes and investigated the function of p38 MAPK in response to heat stress and mechanical stress. Chondrocytes were isolated from human cartilage and cultured. Expression of p38 and phosphorylated p38 in cartilage of patients with osteoarthritis (OA) was compared to those in normal cartilage by immunohistochemistry and Western blotting. Human knee chondrocytes were exposed to heat stress or mechanical stress. Normal knee chondrocytes were pre-treated with SB203580 or p38 small interfering RNA (siRNA) before induction of heat stress or mechanical stress. Chondrocyte apoptosis was detected by TUNEL staining and Western blotting of cleaved caspases. OA and normal chondrocytes expressed p38; however, OA chondrocytes showed much higher phosphorylated p38 compared to normal chondrocytes. Heat stress or mechanical stress induced apoptosis and increased phosphorylated p38 in normal chondrocytes. The TUNEL positive cells and expression levels of phosphorylated p38 in response to stress decreased when chondrocytes were incubated with SB203580 or transfected with siRNA against p38. In conclusion, we have demonstrated that heat stress or mechanical stress increased chondrocyte apoptosis via phosphorylation of p38. Stress-induced chondrocyte apoptosis decreased due to inhibition of p38 MAPK activation. In contrast, the phosphorylation of p38 MAPK increased in OA chondrocytes. Our results show that down-regulation of p38 MAPK activation inhibits chondrocyte death induced by heat stress or mechanical stress.SPANDIDOS PUBL LTD, 2011年03月, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 27(3) (3), 329 - 335, 英語[査読有り]研究論文（学術雑誌）
- We present a rare case of avulsion-fracture of the anterior superior iliac spine with meralgia paresthetica in a 16-year-old male basketball player. He had sensory disturbance affecting his left lateral thigh 10 days after the injury. Tinel's sign was elicited on percussing the avulsed bony fragment of the anterior superior iliac spine. He underwent open reduction and internal fixation. The lateral femoral cutaneous nerve was noted to be entrapped by one third of the avulsed bony fragment. That fragment was removed, and the remaining portion was reduced and fixed with 2 screws. At week 6, the patient had returned to basketball playing without pain. At week 8, sensory distribution in the left lateral thigh had returned to normal.2011年, Journal of orthopaedic surgery (Hong Kong), 19(3) (3), 384 - 385, 英語研究論文（学術雑誌）
- Introduction. Osteoarthritis of the talonavicular joint caused by inflammatory, degenerative, and post-traumatic arthritis has been commonly described, and isolated arthrodesis for talonavicular joint has usually been performed for such conditions. However, arthritis accompanied by pseudarthrosis of the navicular bone is an extremely rare case, and to the best of our knowledge, isolated arthrodesis for this situation has not been previously described in any published reports. Case presentation. The patient was a 39-year-old Japanese man. He had complained of pain in his left middle foot since a fall from his motorcycle six months previously. Radiographs and computed tomography (CT) scans revealed pseudarthrosis of the navicular bone. MRI indicated mild arthritic change in the talonavicular joint and avascular necrosis of the navicular bone. We performed an isolated arthrodesis of the talonavicular joint with two 6.5 mm cancellous screws. One year after the operation, radiographical bone union had been obtained, and the patient reported no pain and complete satisfaction with the result. Conclusions: Isolated talonavicular arthrodesis is one of the effective procedures for the treatment of traumatic talonavicular arthritis with pseudarthrosis of the navicular bone both in providing pain relief and functional improvement. © 2011 Kanzaki et al licensee BioMed Central Ltd.2011年, Journal of Medical Case Reports, 5, 英語[査読有り]研究論文（学術雑誌）
- Neurovascular injury during total hip revision arthroplasty is rare, but potentially catastrophic. We report two patients requiring revision total hip arthroplasty with intrapelvic screw tips located close to the iliac artery. The screw tips were separated from artery by a retroperitoneal exposure prior to revision surgery. Assessment of screw position by computed tomography (CT) is important prior to revision total hip arthroplasty.SAGE PUBLICATIONS LTD, 2011年01月, HIP INTERNATIONAL, 21(1) (1), 125 - 127, 英語[査読有り]研究論文（学術雑誌）
- The therapeutic potential of hematopoietic stem cells/endothelial progenitor cells (HSCs/EPCs) for fracture healing has been demonstrated with evidence for enhanced vasculogenesis/angiogenesis and osteogenesis at the site of fracture. The adaptor protein Lnk has recently been identified as an essential inhibitor of stem cell factor (SCF)-cKit signaling during stem cell self-renewal, and Lnk-deficient mice demonstrate enhanced hematopoietic reconstitution. In this study, we investigated whether the loss of Lnk signaling enhances the regenerative response during fracture healing. Radiological and histological examination showed accelerated fracture healing and remodeling in Lnk-deficient mice compared with wild-type mice. Molecular, physiological, and morphological approaches showed that vasculogenesis/angiogenesis and osteogenesis were promoted in Lnk-deficient mice by the mobilization and recruitment of HSCs/EPCs via activation of the SCF-cKit signaling pathway in the perifracture zone, which established a favorable environment for bone healing and remodeling. In addition, osteoblasts (OBs) from Lnk-deficient mice had a greater potential for terminal differentiation in response to SCF-cKit signaling in vitro. These findings suggest that inhibition of Lnk may have therapeutic potential by promoting an environment conducive to vasculogenesis/angiogenesis and osteogenesis and by facilitating OB terminal differentiation, leading to enhanced fracture healing.ROCKEFELLER UNIV PRESS, 2010年09月, JOURNAL OF EXPERIMENTAL MEDICINE, 207(10) (10), 2207 - 2223, 英語[査読有り]研究論文（学術雑誌）
- Retroperitoneal abscess following infected bipolar hemiarthroplasty diagnosed by metallosis: A case reportWe present a patient with the rare association of a retroperitoneal abscess and infected bipolar hemiarthroplasty diagnosed by metallosis in the abscess preoperatively. T1 and T2 weighted magnetic resonance images revealed a very low signal area, suggesting the presence of particulate metal in the abscess. Critical interpretation of imaging may be useful in such cases. 2010 Wichtig Editore.2010年07月, HIP International, 20(3) (3), 338 - 339, 英語[査読有り]研究論文（学術雑誌）
- Decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor (TNFR) superfamily, is a soluble receptor that binds to the TNF family including Fas ligand (Fas-L), LIGHT, and TL1A. DcR3 is mostly expressed in tumor cells and competitively inhibits the TNF family. We previously demonstrated that overexpressed DcR3 in rheumatoid synovial cells protects the cells from apoptosis in vitro. The objective of the study was to investigate DcR3 expression in serum and joint fluids of patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and to analyze the correlations with disease activities and TNFα expression. Sera and joint fluids were collected from patients with RA and OA. Expression of DcR3 in sera and joint fluids was measured by ELISA. The concentration of DcR3 in sera and joint fluids of RA patients was significantly higher than that in sera and joint fluids of OA patients. A correlation between serum DcR3 concentration and disease activity was not observed, but the serum DcR3 concentration was strongly correlated with the TNFα concentration. DcR3 was highly expressed in serum and joint fluids of RA patients. © 2009 Japan College of Rheumatology.2010年02月, Modern Rheumatology, 20(1) (1), 63 - 68, 英語[査読有り]研究論文（学術雑誌）
- In order to analyze the function of DcR3 for the regulation of cell adhesion and apoptosis in macrophages, we investigated the expression of decoy receptor 3 (DcR3) in THP-1 monocytes/macrophages. DcR3 was expressed in THP-1 and increased by phorbol 12-myristate 13-acetate (PMA). The formation of macrophage aggregates was observed when THP-1 cells were differentiated by PMA or stimulated with DcR3-Fc. Undifferentiated THP-1 cells were also induced to form aggregates by DcR3-Fc. The expression of integrin α4 was significantly increased by DcR3-Fc. CHX-induced apoptosis in THP-1 was inhibited by DcR3-Fc, of which inhibition against CHX-induced apoptosis and aggregate formation were ameliorated by anti-VLA4 antibody. DcR3 may play a significant role in macrophages not only by a decoy receptor but also by increasing α4 integrin. © 2009 Elsevier Inc. All rights reserved.2009年11月, Biochemical and Biophysical Research Communications, 389(4) (4), 593 - 598, 英語[査読有り]研究論文（学術雑誌）
- Objective. SIRT1 is known to inhibit apoptosis and to promote survival of various types of cells. However, the roles of SIRT1 in apoptosis of human chondrocytes have never been reported. We undertook this study to investigate the relationship of SIRT1 to apoptosis of human chondrocytes, which is a characteristic feature of osteoarthritis (OA). Methods. The expression of SIRT1 in human chondrocytes was examined by reverse transcription-polymerase chain reaction, immunoblotting, and immunohistology of human cartilage samples. The expression of SIRT1 under catabolic, mechanical, and nutritional stresses was investigated by immunoblotting. To examine the effect of SIRT1 on apoptosis, SIRT1 was inhibited by small interfering RNA (siRNA) and activated by resveratrol during nitric oxide (NO)-induced apoptosis. TUNEL staining and immunoblotting of cleaved poly(ADP-ribose) polymerase (PAR-P) were performed to detect apoptosis. To examine the mechanisms of apoptosis, we used immunoblotting to determine the levels of cleaved caspases and mitochondria-related apoptotic signaling proteins, Bax and Bcl-2, in the mitochondrial fraction. Results. SIRT1 expression was confirmed in human chondrocytes and human cartilage samples. All catabolic, mechanical, and nutritional stresses inhibited SIRT1 expression. SIRT1 inhibition by siRNA for SIRT1 increased the percentage of TUNEL-positive cells and increased the amounts of cleaved PARP and cleaved caspases 3 and 9 induced by NO. In contrast, treatment with resveratrol decreased the percentage of TUNEL-positive cells and decreased the amounts of cleaved PARP and cleaved caspases 3 and 9 induced by NO. Furthermore, in the mitochondrial fraction, SIRT1 inhibition by siRNA for SIRT1 increased the amount of Bax but reduced the amount of Bcl-2, while resveratrol reduced the amount of Bax but increased the amount of Bcl-2. Conclusion. These results indicate that SIRT1 regulates apoptosis in human chondrocytes through the modulation of mitochondria-related apoptotic signals. Further research on SIRT1 might contribute to resolving the pathogenesis of OA.WILEY, 2009年09月, ARTHRITIS AND RHEUMATISM, 60(9) (9), 2731 - 2740, 英語[査読有り]研究論文（学術雑誌）
- Objective. Chondrocyte apoptosis plays an important role in cartilage degeneration in osteoarthritis (OA), and mechanical injury to cartilage induces chondrocyte apoptosis. In response to DNA damage, p53 expression is up-regulated, transcription activity is increased, and apoptosis signals are initiated. The p53-regulated apoptosis-inducing protein 1 (p53AIP-1) is one of the p53-regulated genes, and is activated in response to DNA damage. This study was undertaken to analyze p53 function after induction of apoptosis by shear strain in chondrocytes. Methods. OA cartilage samples were obtained from subjects undergoing total knee replacement surgery, and normal cartilage samples were obtained from subjects undergoing surgery for femoral neck fracture. Chondrocytes were isolated from human cartilage and cultured. Expression of p53 and p53AIP in chondrocytes was detected by reverse transcriptase-polymerase chain reaction and Western blotting. Shear strain was introduced in normal human knee chondrocytes. To explore p53 function, normal human knee chondrocytes were pretreated with pifithrin-alpha or p53 small interfering RNA (siRNA) before induction of shear strain. Chondrocyte apoptosis was detected by expression of cleaved caspase 9 with Western blotting and TUNEL staining. Expression of p53 and p53AIP-1 was analyzed by Western blotting. Results. OA and normal chondrocytes expressed p53. OA chondrocytes showed much higher expression of p53 and p53AIP-1 than did normal chondrocytes. TUNEL-positive cells and expression of p53, p53AIP-1, and cleaved caspase 9 were increased by shear strain, but chondrocyte apoptosis was suppressed after pretreatment with pifithrin-alpha or p53 siRNA. Conclusion. Our findings indicate that p53 and p53AIP-1 play important roles in human chondrocyte apoptosis. Down-regulation of p53 expression prevents cartilage from undergoing apoptosis introduced by shear strain.WILEY-LISS, 2009年08月, ARTHRITIS AND RHEUMATISM, 60(8) (8), 2340 - 2349, 英語[査読有り]研究論文（学術雑誌）
- Objective: With the proper safety procedures, we investigated the possibility of reducing the infusion time of infliximab (INFX) in patients with rheumatoid arthritis (RA) to 1 hour to decrease the burden of infusion on patients.日本関節病学会, 2009年, 日本関節病学会誌, 28(4) (4), 515 - 519, 英語
Methods: In patients with RA treated at least 5 times with 2-hour infusion of INFX without adverse infusion reactions, the infusion time was reduced to 90 min. Only in patients successfully treated with 90-min infusion of INFX without infusion reactions at least twice was the infusion time further reduced to 1 hour.
Results: Thirty patients (26 females & 4 males, mean age: 49.1±15.6 years, history of RA: 8.2±8.8 years) were treated with 2-hour INFX infusion. Five of the 30 showed various infusion reactions, whereas 25 of the 30 were treated successfully without infusion reactions 12.4±6.5 times. Twenty-two of the 25 patients were subsequently treated with 90-min infusion 3.4±2.5 times and only 1 patient showed a mild infusion reaction. Seventeen of the 21 were then treated with 1-hour infusion 6.1±4.1 times and only 1 patient showed a very mild infusion reaction. The infusion reaction occurring when the infusion time was reduced to 90 min was treated with the administration of antihistamine and acetaminophen, and the infusion of INFX was completed with a decreased 2-hour infusion rate. In the case of the patient who had an infusion reaction associated with the 1-hour infusion, the reaction was very mild and it was successfully treated immediately by simply slowing down the infusion rate to 2 hours.
Conclusion: The infusion time of INFX can be safely reduced by up to 1 hour without severe adverse effects in patients with RA who have been successfully treated at least 5 times with a 2-hour INFX infusion rate without infusion reactions. - Background. The most common failure of total joint replacement is aseptic loosening in association with osteolysis. Previous reports have shown that prostaglandin E-2 (PGE(2)) secreted from macrophages that phagocytosed wear debris induced periprosthetic osteolysis. Many clinical studies have reported that bisphosphonate therapy reduced periprosthetic bone loss and loosening of the implants after total joint replacements. Bisphosphonates are synthetic compounds with the ability to decrease bone resorption. In addition, some bisphosphonates have been reported to have anti-inflammatory effects by reducing the secretion of pro-inflammatory cytokines. However, the mechanism of bisphosphonates that reduces periprosthetic bone resorption remains unclear. The purpose of this study was to investigate one of the mechanisms by which etidronate (EHDP) inhibits periprosthetic bone resorption. Methods. Macrophage-like RAW 264.7 cells were treated with EHDP at concentrations of 0.001, 0.01, 0.1, 1, 10, and 100 mu M together with the titanium particles at a concentration of 1 mg/ml. After a 24-h culture period, total mRNA was isolated and reverse transcription-polymerase chain reaction (RT-PCR) was done to examine the expression of cyclooxygenase-2 (COX-2). The supernatants were also collected and production of PGE(2), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were quantified using an enzyme-linked immunosorbent assay (ELISA). Results. Analyses showed that COX-2 expression and PGE(2) production were suppressed by EHDP in a dose-dependent manner. By 100 mu M of EHDP, PGE(2) production of the cells was suppressed approximately to the level of the nonstimulated cells. Production of IL-1 beta, IL-6, and TNF-alpha in the supernatant was also suppressed by EHDP. Conclusions. The blockage effect of pro-inflammatory cytokines is a possible etidronate mechanism that reduces bone resorption around implants.SPRINGER TOKYO, 2007年11月, JOURNAL OF ORTHOPAEDIC SCIENCE, 12(6) (6), 568 - 577, 英語[査読有り]研究論文（学術雑誌）
- BACKGROUND - Therapeutic effect of stem cell transplantation (SCTx) for myocardial neovascularization has been evaluated by histological capillary density in small animals. However, it has been technically difficult to obtain imaging evidence of collateral formation by conventional angiography. METHODS AND RESULTS - Peripheral blood CD34+ and CD34- cells were isolated from patients with critical limb ischemia. PBS, CD34- cells, or CD34+ cells were intramyocardially transplanted after ligating LAD of nude rats. Coronary angiography of ex vivo beating hearts 5 and 28 days after the treatment was performed using the third generation synchrotron radiation microangiography (SRM), which has potential to visualize vessels as small as 20 μm in diameter. The SRM was performed pre and post sodium nitroprusside (SNP) to examine vascular physiology at each time point. Diameter of most collateral vessels was 20 to 120 μm, apparently invisible size in conventional angiography. Rentrop scores at day 28 pre and post SNP were significantly greater in CD34+ cell group than other groups (P< 0.01). To quantify the extent of collateral formation, angiographic microvessel density (AMVD) in the occluded LAD area was analyzed. AMVD on day 28 post SNP, not pre SNP, was significantly augmented in CD34+ cell group than other groups (P< 0.05). AMVD post SNP closely correlated with histological capillary density (R=0.82, P< 0.0001). CONCLUSIONS - The SRM, capable of visualizing microvessels, may be useful for morphometric and physiological evaluation of coronary collateral formation by SCTx. The novel imaging system may be an essential tool in future preclinical/translational research of stem cell biology. © 2007 American Heart Association, Inc.2007年06月, Arteriosclerosis, Thrombosis, and Vascular Biology, 27(6) (6), 1326 - 1333, 英語[査読有り]研究論文（学術雑誌）
- Objective. Decoy receptor 3 (DcR3), a newly identified member of the tumor necrosis factor receptor (TNFR) superfamily, is a soluble receptor that binds to members of the TNF family, including FasL, LIGHT, and TNF-like molecule 1A. DcR3 is mostly expressed in tumor cells, and it competitively inhibits binding of TNF to TNFRs. The present study was undertaken to investigate DcR3 expression in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), and to analyze the effects of DcR3 on Fas-induced apoptosis in RA FLS. Methods. Expression of DcR3 in FLS was measured by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. FLS were incubated with DcR3-Fc chimera protein or transfected with DcR3 small interfering RNA (siRNA) using the lipofection method, before induction of apoptosis. Apoptosis induced by Fas in FLS was detected with TUNEL staining and Western blotting of caspase 8 and poly(ADP-ribose) polymerase. Finally, FLS were incubated with TNFα prior to Fas-induced apoptosis, expression of DcR3 was analyzed by quantitative RT-PCR, and apoptosis was measured. Results. DcR3 was expressed in both RA FLS and OA FLS. DcR3-Fc protein inhibited Fas-induced apoptosis in FLS. Down-regulation of DcR3 in FLS by siRNA increased Fas-induced apoptosis. TNFα increased DcR3 expression and inhibited Fas-induced apoptosis in RA FLS, but not in OA FLS. Conclusion. DcR3 expressed in RA FLS is increased by TNFα and protects the cells against Fas-induced apoptosis. These findings indicate that DcR3 may be a possible therapeutic target in RA. © 2007, American College of Rheumatology.2007年04月, Arthritis and Rheumatism, 56(4) (4), 1067 - 1075, 英語[査読有り]研究論文（学術雑誌）
- Failures in fracture healing are mainly caused by a lack of vascularization. Adult human circulating CD34(+) cells, an endothelial/hematopoietic progenitor-enriched cell population, have been reported to differentiate into osteoblasts in vitro; however, the therapeutic potential of CD34(+) cells for fracture healing is still unclear. Therefore, we performed a series of experiments to test our hypothesis that functional fracture healing is supported by vasculogenesis and osteogenesis via regenerative plasticity of CD34(+) cells. Peripheral blood CD34(+) cells, isolated from total mononuclear cells of adult human volunteers, showed gene expression of osteocalcin in 4 of 20 freshly isolated cells by single cell reverse transcriptase-polymerase chain reaction analysis. Phosphate-buffered saline, mononuclear cells, or CD34(+) cells were intravenously transplanted after producing nonhealing femoral fractures in nude rats. Reverse transcriptase-polymerase chain reaction and immunohistochemical staining at the peri-fracture site demonstrated molecular and histological expression of human-specific markers for endothelial cells and osteoblasts at week 2. Functional bone healing assessed by biomechanical as well as radiological and histological examinations was significantly enhanced by CD34(+) cell transplantation compared with the other groups. Our data suggest circulating human CD34(+) cells have therapeutic potential to promote an environment conducive to neovascularization and osteogenesis in damaged skeletal tissue, allowing the complete healing of fractures.ELSEVIER SCIENCE INC, 2006年10月, AMERICAN JOURNAL OF PATHOLOGY, 169(4) (4), 1440 - 1457, 英語[査読有り]研究論文（学術雑誌）
- 2006年09月, ARTHRITIS AND RHEUMATISM, 54(9) (9), S812Angiopoietin-1 acts onto alpha 5 beta 1 integrin (VLA-5) to activate MAP kinases in rheumatoid synovial cells.[査読有り]
- 2006年03月, 日本リウマチ学会総会・学術集会抄録集, pp.176-176, 日本語関節リウマチの臨床 リウマチ性疾患患者の不安と抑鬱状態の評価研究論文（国際会議プロシーディングス）
- 2006年03月, 日本リウマチ学会総会・学術集会抄録集, pp.106-106, 日本語関節リウマチの治療 メトトレキサートとレフルノミド 当科におけるレフルノミドの使用成績と,中止後の治療方法の検討研究論文（国際会議プロシーディングス）
- 2006年03月, 日本リウマチ学会総会・学術集会抄録集, pp.194-194, 日本語滑膜増殖と制御 関節リウマチ滑膜細胞におけるdecoy receptor 3の機能解析研究論文（国際会議プロシーディングス）
- (一社)日本リウマチ学会, 2005年04月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 49回・14回, 233 - 233, 日本語関節リウマチ滑膜細胞発現Death Receptor 3(DR3)の機能解析
- (一社)日本リウマチ学会, 2005年04月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 49回・14回, 234 - 234, 日本語関節リウマチ滑膜細胞におけるDcR3発現の解析
- Pseudarthrosis, often associated with neurofibromatosis, usually is present at birth or is the result of pathologic fracture. We present a rare case of a 29-month-old patient with acquired pseudarthrosis in radiographically normal bone. Copyright © 2005 by the American Society for Surgery of the Hand.2005年01月, Journal of Hand Surgery, 30(1) (1), 168 - 171, 英語[査読有り]研究論文（学術雑誌）
- 2005年01月, 日本肘関節学会雑誌, 12巻, 1号, pp. S56-S56, 日本語上腕動脈の血栓除去術を必要とした小児上腕骨顆上骨折の1例研究論文（国際会議プロシーディングス）
- 2000年08月, Kaibogaku zasshi. Journal of anatomy, 75(4) (4), 377 - 380[Morphological basis of periodontal nerve endings].[査読有り]
- 1999年, Clinical and Experimental Allergy, 29(12) (12), 1593 - 1596, 英語[査読有り]研究論文（学術雑誌）
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2TRAに対するJAK阻害薬治療による低疾患活動性達成に関連する因子の解析
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2TRAに対するJAK阻害薬の有効性に関するX線学的評価の比較~トファシチニブ対バリシチニブ~
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2T RA患者に対するバリシチニブの有効性に関してのX線学的検討~non-D2T RA患者との比較~
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2T RA患者とnon-D2T RA患者のBaricitinib導入初期の疾患活動性の比較
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2T RA患者に対するJAK阻害薬(TOF,BAR)の有効性に関してのX線学的検討~non-D2T RA患者との比較~
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2T RA患者のb/tsDMARDs導入初期の疾患活動性の特徴~non-D2T RA患者との比較~
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2TRAに対するトファシチニブとバリシチニブの臨床成績
- 2023年, 日本臨床リウマチ学会プログラム・抄録集, 38thD2T RA患者に対するJAC阻害薬(Tofacitinib)の治療効果について
- 2023年, 日本整形外科学会雑誌, 97(2) (2)発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討
- 2022年, 日本股関節学会学術集会プログラム・抄録集, 49th発育性股関節形成不全と無症候性股関節の放射線画像における骨形態の比較検討
- This study observed anterior coverage extent after lateral rotation of the acetabulum, without anterior or posterior rotation, during curved periacetabular osteotomy by three-dimensional simulation, and determined if preoperative pelvic morphology affects postoperative anterior coverage and range of motion. Thirty patients scheduled for consecutive primary curved periacetabular osteotomy for developmental hip dysplasia at our hospital between 2016 and 2017 were included. Virtual acetabular osteotomies were performed to achieve a postoperative lateral center-edge angle of 30°. We measured anterior center-edge angles before curved periacetabular osteotomy through the medial one-third and one-quarter of the femoral head as an index reflecting the pelvic morphology medial to the femoral head center. The range of motion simulation was performed after virtual curved periacetabular osteotomy. Single linear regression analysis was performed to examine correlations between preoperative pelvic morphology parameters and anterior center-edge angles after virtual osteotomy. Furthermore, linear regression analysis was used to assess correlations between center-edge angles and simulated range of motions (P < .05). Anterior center-edge angle after virtual osteotomy was more strongly correlated with the anterior center-edge angle through the medial one-third (r = .92, P < .0001) and one-quarter (r = .84, P < .0001) of the femoral head. Flexion angle and internal rotation at 90° flexion showed significant correlations with anterior center-edge angle through the medial one-third (r = -.62, P = .0003; r = -.57, P = .001) and one-quarter (r = -.60, P = .0005; r = -.55, P = .002) of the femoral head and anterior center-edge angle after virtual osteotomy (r = -.67, P = .0005; r = -.62, P = .0003). Measuring preoperative parameters reflecting pelvic morphology enables surgeons to predict postoperative anterior coverage and range of motion in curved periacetabular osteotomy cases.2020年02月08日, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 38(9) (9), 2031 - 2039, 英語, 国際誌
- 2020年, 日本リウマチ学会総会・学術集会プログラム・抄録集, 64th (CD-ROM)多剤耐性因子MDR1発現に対するJAK阻害薬の影響の検討
- 2020年, 日本リウマチ学会総会・学術集会プログラム・抄録集, 64th (CD-ROM)関節リウマチの高齢発症に関与する遺伝子の探索
- (公社)日本整形外科学会, 2019年09月, 日本整形外科学会雑誌, 93(8) (8), S1753 - S1753, 日本語脂肪由来幹細胞の難治性骨折に対する治癒促進効果
- (公社)日本整形外科学会, 2019年09月, 日本整形外科学会雑誌, 93(8) (8), S1829 - S1829, 日本語巨細胞性動脈炎におけるMMP-9の役割
- (公社)日本整形外科学会, 2019年09月, 日本整形外科学会雑誌, 93(8) (8), S1954 - S1954, 日本語エイコサペンタエン酸含有ゼラチンハイドロゲルは変形性関節症進行を抑制する
- 2019年, 日本臨床リウマチ学会プログラム・抄録集, 34th関節リウマチ患者に対するイグラチモドの治療継続率
- (株)ライフメディコム, 2018年10月, カレントテラピー, 36(10号) (10号), 970 - 979, 日本語【骨粗鬆症診療の真の目的は何か?!-脆弱性骨折の予防と診療の最前線】 脆弱性骨折の連鎖 ケーススタディから学ぶ[査読有り]記事・総説・解説・論説等（学術雑誌）
- WILEY, 2017年10月, ARTHRITIS & RHEUMATOLOGY, 69, 英語Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium研究発表ペーパー・要旨（国際会議）
- WILEY, 2017年10月, ARTHRITIS & RHEUMATOLOGY, 69, 英語Decoy Receptor 3 up-Regulates Cadherin 2 in Rheumatoid Synovial Fibroblasts研究発表ペーパー・要旨（国際会議）
- 2017年02月, 関節外科, 36(2号) (2号), 124 - 130, 日本語【FAI(大腿骨寛骨臼インピンジメント)の最新知見】 FAIに関する基礎的研究の最新知見[招待有り]記事・総説・解説・論説等（学術雑誌）
- SPRINGER LONDON LTD, 2016年11月, OSTEOPOROSIS INTERNATIONAL, 27, S784 - S784, 英語EVALUATION OF BONE METABOLISM AND QOL IN PATIENTS WITH OSTEOPOROSIS AFTER TREATMENT WITH THE ANTI-RANKL ANTIBODY DENOSUMAB研究発表ペーパー・要旨（国際会議）
- BMJ PUBLISHING GROUP, 2016年06月, ANNALS OF THE RHEUMATIC DISEASES, 75, 922 - 922, 英語研究発表ペーパー・要旨（国際会議）
- 2016年05月, Orthopaedics, 29(5号) (5号), 25 - 33, 日本語【復帰を早めるスポーツ損傷低侵襲手術テクニック】 ＜下肢＞股関節唇損傷に対する関節鏡視下手術記事・総説・解説・論説等（その他）
- ELSEVIER SCI LTD, 2016年04月, OSTEOARTHRITIS AND CARTILAGE, 24, S386 - S387, 英語P21 DEFICIENCY IS SUSCEPTIBLE TO OSTEOARTHRITIS WITH INFLAMMATION研究発表ペーパー・要旨（国際会議）
- SPRINGER LONDON LTD, 2016年04月, OSTEOPOROSIS INTERNATIONAL, 27, S126 - S127, 英語EVALUATION OF BONE METABOLISM MARKERS AND QOL IN PATIENTS WITH OSTEOPOROSIS AFTER TREATMENT WITH THE ANTI-RANKL ANTIBODY DENOSUMAB研究発表ペーパー・要旨（国際会議）
- 2016年04月, 別冊整形外科, (69号) (69号), 147 - 151, 日本語【足関節・足部疾患の最新治療】 疾患各論 足関節症 変形性足関節症 人工足関節全置換術 変形性足関節症・関節リウマチに対する人工足関節全置換術[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 金原出版, 2016年01月, 整形・災害外科, 59(1) (1), 35 - 42, 日本語チェンジャブルネック (特集 最近の人工股関節合併症とその対策)
- BMJ PUBLISHING GROUP, 2015年06月, ANNALS OF THE RHEUMATIC DISEASES, 74, 167 - 167, 英語研究発表ペーパー・要旨（国際会議）
- 2015年03月, 日本整形外科学会雑誌, 89(3号) (3号), S695, 日本語人工足関節置換術において術前可動域は術後可動域に影響を与えるか[査読有り]会議報告等
- WILEY-BLACKWELL, 2014年10月, ARTHRITIS & RHEUMATOLOGY, 66, S1073 - S1073, 英語Centrosomal Protein 70kDa Is Down-Regulated By Decoy Receptor 3 in Specifically Rheumatoid Synovial Fibroblasts.研究発表ペーパー・要旨（国際会議）
- 日本RAのリハビリ研究会, 2014年06月, 日本RAのリハビリ研究会誌, 28(1) (1), 46 - 48, 日本語関節リウマチ患者に対する人工股関節全置換術後在院日数予測モデルの逸脱要因 : ディシジョンツリー分析を用いた検討
- 2014年05月, The Japanese Journal of Rehabilitation Medicine, 51(Suppl.) (Suppl.), S308, 日本語距骨に骨軟骨腫を生じた一例[査読有り]会議報告等
- ELSEVIER SCI LTD, 2014年04月, OSTEOARTHRITIS AND CARTILAGE, 22, S432 - S433, 英語REMOTE ASSESSMENTS AND INSTRUCTIONS FOR HOME-REHABILITATION VIA CUSTOM-MADE WEBSITE IN PATIENTS WITH HIP AND KNEE OSTEOARTHRITIS, A PRELIMINARY REPORT研究発表ペーパー・要旨（国際会議）
- 2014年04月, 日本臨床, 72(増刊3 最新関節リウマチ学) (増刊3 最新関節リウマチ学), 68 - 72, 日本語【最新関節リウマチ学-寛解・治癒を目指した研究と最新治療-】 関節リウマチの発症要因と発症メカニズム 発症メカニズム DcR3による遺伝子発現誘導[招待有り]記事・総説・解説・論説等（学術雑誌）
- 2014年, 日本股関節学会学術集会プログラム・抄録集, 41st, 250, 日本語FAIの分子生物学的特徴
- WILEY-BLACKWELL, 2013年10月, ARTHRITIS AND RHEUMATISM, 65, S582 - S582, 英語Decoy Receptor 3 Regulates the Expression of Tryptophan Hydroxylase TPH1 in Rheumatoid Synovial Fibroblasts研究発表ペーパー・要旨（国際会議）
- (公社)日本整形外科学会, 2013年08月, 日本整形外科学会雑誌, 87(8) (8), S1416 - S1416, 日本語DcR3は関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1の発現を制御する会議報告等
- (公社)日本整形外科学会, 2013年08月, 日本整形外科学会雑誌, 87(8) (8), S1423 - S1423, 日本語DcR3による関節リウマチ滑膜細胞におけるIL-12Bp40発現誘導の検討会議報告等
- ELSEVIER SCI LTD, 2013年04月, OSTEOARTHRITIS AND CARTILAGE, 21, S132 - S133, 英語PTEN REGULATES THE EXPRESSIONS OF TYPEII COLLAGEN AND AGGRECAN UNDER OXIDATIVE STRESS IN HUMAN CHONDROCYTES研究発表ペーパー・要旨（国際会議）
- ELSEVIER SCI LTD, 2013年04月, OSTEOARTHRITIS AND CARTILAGE, 21, S36 - S37, 英語OXIDATIVE STRESS INDUCED CHONDROCYTES APOPTOSIS WERE INHIBITED BY EICOSAPENTAENOIC ACID研究発表ペーパー・要旨（国際会議）
- ELSEVIER SCI LTD, 2013年04月, OSTEOARTHRITIS AND CARTILAGE, 21, S46 - S47, 英語P21 REGULATES MMP-13 EXPRESSION THROUGH STAT3 SIGNALING IN CHONDROCYTES研究発表ペーパー・要旨（国際会議）
- (一社)日本リウマチ学会, 2013年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 57回・22回, 327 - 327, 日本語関節リウマチの病因・病態 関節リウマチ滑膜細胞におけるDcR3によるIL-12B p40発現誘導の検討会議報告等
- (一社)日本リウマチ学会, 2013年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 57回・22回, 418 - 418, 日本語関節リウマチの治療 生物学的製剤(TNF阻害薬) インフリキシマブ時間短縮投与の忍容性 6年間の経験[査読有り]会議報告等
- (一社)日本リウマチ学会, 2013年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 57回・22回, 442 - 442, 日本語リハビリテーション 楽器を用いたリウマチ患者に対する音楽療法に関する検討[査読有り]会議報告等
- (一社)日本リウマチ学会, 2013年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 57回・22回, 556 - 556, 日本語DcR3は関節リウマチ滑膜線維芽細胞においてトリプトファン水酸化酵素TPH1の発現を制御する会議報告等
- (公社)日本整形外科学会, 2012年08月, 日本整形外科学会雑誌, 86(8) (8), S1367 - S1367, 日本語関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素TPH1発現の検討[査読有り]会議報告等
- ELSEVIER SCI LTD, 2012年04月, OSTEOARTHRITIS AND CARTILAGE, 20, S149 - S150, 英語THE EXPRESSIONS OF TYPEII COLLAGEN IS REGULATED BY PTEN IN HUMAN CHODROCYTES.研究発表ペーパー・要旨（国際会議）
- (一社)日本リウマチ学会, 2012年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 56回・21回, 550 - 550, 日本語関節リウマチ滑膜線維芽細胞におけるトリプトファン水酸化酵素発現の検討[査読有り]会議報告等
- (一社)日本リウマチ学会, 2012年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 56回・21回, 338 - 338, 日本語関節リウマチの病因・病態(1) 関節リウマチ滑膜細胞におけるDcR3による遺伝子発現誘導の検討[査読有り]会議報告等
- (一社)日本リウマチ学会, 2012年03月, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 56回・21回, 403 - 403, 日本語関節リウマチの関節外病変(1) 関節リウマチ患者の胃食道逆流症(GERD)に関する検討[査読有り]会議報告等
- 南江堂, 2011年12月, 整形外科, 62(13) (13), 1388 - 1390, 日本語臨床室 上前腸骨棘裂離骨折に合併した外側大腿皮神経麻痺の1例
- ELSEVIER SCI LTD, 2011年09月, OSTEOARTHRITIS AND CARTILAGE, 19, S108 - S108, 英語MECHANICAL STRESS INCREASED P21(CIP1)EXPRESSION IN CHONDROCYTES研究発表ペーパー・要旨（国際会議）
- ELSEVIER SCI LTD, 2011年09月, OSTEOARTHRITIS AND CARTILAGE, 19, S114 - S114, 英語THE EXPRESSION OF TYPE2 COLLAGEN IS REGULATED BY PTEN IN CHONDROCYTES研究発表ペーパー・要旨（国際会議）
- 2011年05月31日, 日本足の外科学会雑誌 = The journal of the Japanese Society for Surgery of the Foot, 32(2) (2), 194 - 197, 日本語舟状骨偽関節に伴う変形性距舟関節症の一例
- W B SAUNDERS CO LTD, 2010年10月, OSTEOARTHRITIS AND CARTILAGE, 18, S123 - S124, 英語INVOLVEMENT OF P38 MAP KINASE PHOSPHORYLATION IN CHONDROCYTES APOPTOSIS INDUCED BY HEAT STRESS研究発表ペーパー・要旨（国際会議）
- Expression of DcR3 in bone and soft tissue tumorsDecoy receptor 3 (DcR3) is considered to play an important role in inhibiting Fas-mediated apoptosis. DcR3 binds to FasL, LIGHT and TL1A. DcR3 competes with Fas in binding to FasL and inhibits Fas-mediated apoptosis. DcR3 is overexpressed in colon adenocarcinoma, pancreas adenocarcinoma and neuroblastoma. There is no data available about DcR3 expression in bone and soft tissue tumors. Therefore to analyze the expression of DcR3 in bone and soft tissue tumors, we used 38 malignant bone and soft tissue samples and 12 benign bone and soft tissue samples, and 7 malignant bone and soft tissue cell lines. RT-PCR showed that DcR3 mRNA was highly expressed in malignant bone and soft tissue tumor samples (92%), and benign tumor samples (100%). Real time PCR showed that the ratio of mRNA expression of DcR3 to Fas in malignant tumors was statistically higher than in benign tumors. mRNA expression of DcR3 was correlated with the grade of malignancy. Western blotting showed that DcR3 protein was expressed in osteosarcoma and malignant fibrous histiocytoma (MFH) cell lines as well as DcR3 mRNA. These results suggest that DcR3 may play an important role in inhibiting Fas-mediated apoptosis in bone and soft tissue tumors as well as in other cancers.2009年, Cancer Therapy, 7(ISSUE A) (ISSUE A), 43 - 48[査読有り]
- 2008年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 348, 日本語リウマチ滑膜線維芽細胞に対するDcR3の直接的作用の検討
- 2008年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 360, 日本語関節リウマチ患者に対するインフリキシマブ時間短縮投与の試み
- 2008年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 52nd-17th, 315, 日本語マクロファージ系細胞におけるデコイレセプターDcR3の機能解析
- 2007年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 263, 日本語Angiopoietin‐1は滑膜細胞上のVLA‐5(α5β1インテグリン)を介してシグナル伝達する
- 2007年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 378, 日本語関節リウマチ患者における血清中DcR3濃度の解析‐健常者との比較
- 2007年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 317, 日本語関節リウマチ滑膜線維芽細胞におけるDEC‐205の発現
- 2007年, 日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 51st-16th, 378, 日本語マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討
- BMJ PUBLISHING GROUP, 2005年07月, ANNALS OF THE RHEUMATIC DISEASES, 64, 128 - 128, 英語Death receptor 3 is specially expressed in rheumatoid synovium and TL1A, a physiological ligand for DR3, efficiently induces apoptosis in rheumatoid synovial fibroblasts研究発表ペーパー・要旨（国際会議）
■ 講演・口頭発表等
- 第47回日本股関節学会学術集会脱臼性股関節症に対するロボット支援THAのソケット設置精度検証口頭発表（一般）
- 第93回日本整形外科学会学術集会寛骨臼回転骨切り術において臼蓋傾斜の過度な補正は術後可動域に強く影響するポスター発表
- 第50回日本人工関節学会, 2020年02月, 日本語HA カラードショートステムの術後ステム周囲骨反応変化とステムアライメントとの 関係口頭発表（一般）
- 第46回日本股関節学会学術集会, 2019年10月, 日本語HAカラードショートステムの術後ステム周囲骨反応変化-他のステムと比較して[招待有り]口頭発表（招待・特別）
- 第46回日本股関節学会学術集会, 2019年10月, 日本語寛骨臼回転骨切り術において臼蓋傾斜の補正は前方被覆及び術後可動域に強く影響する口頭発表（一般）
- The 32nd International Society for Technology in Arthroplasty, 2019年10月, 英語Postoperative Excessive Anterior Acetabular Coverage Is Associated With Decrease in Range of Motion After Periacetabular Osteotomy口頭発表（一般）
- 第63回リウマチ学会総会・学術集会, 2019年04月, 日本語RA患者における関節破壊の特徴によるトシリズマブ有効性の検討ポスター発表
- 第32回日本軟骨代謝学会, 2019年03月, 日本語, 日本軟骨代謝学会, 大阪, 国内会議骨膜パッチを用いない自家培養軟骨細胞移植 ー治験の経験からーシンポジウム・ワークショップパネル（指名）
- 第32回日本軟骨代謝学会, 2019年03月, 日本語, 日本軟骨代謝学会, 大阪, 国内会議サイクリンディペンデントキナーゼインヒビター１欠損マウスは炎症の増悪を伴い変形性関節症が進行する[招待有り]口頭発表（招待・特別）
- AAOS annual meeting 2019, 2019年03月, 英語, American Academy of Orthopaedic Surgeons, Las Vegas, 国際会議Postoperative excessive anterior acetabular coverage is associated with decrease in range of motion after periacetabular osteotomyポスター発表
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議単顆型人工膝関節置換術の術後患者満足度に影響を及ぼす因子の検討ポスター発表
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議前外側アプローチでの人工股関節全置換術における腸骨大腿靱帯および恥骨大腿靱帯温存の試み口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議仰臥位THAの術中の骨盤安定性に影響する因子の検討口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議仰臥位THAにおけるポータブルナビゲーションの精度評価とラーニングカーブ口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議セメントレストリプルテーパー型カーブドショートステム周囲の術後2年の骨密度変化口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議TriLock stem使用症例の中期成績口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議TKA後10年の下肢alignment変化とその変化に関連する因子の検討口頭発表（一般）
- The 65th Annual Meeting of Orthopaedic Research Society, 2019年02月, 英語, Orthopaedic Research Society, Austin, 国際会議Therapeutic effects of adipose derived regenerative cells for fracture healing using rat unhealing fracture model.ポスター発表
- The 65th Annual Meeting of Orthopaedic Research Society, 2019年02月, 英語, Orthopaedic Research Society, Austin, 国際会議The Influence of Gelatin Hydrogel Including EicosapentaenoicAcid on the Osteoarthritis Progression in Vivoポスター発表
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議Robotic-arm assisted THAの初期精度評価口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議POLARステム使用THAにおける術前計画と使用サイズの差異口頭発表（一般）
- The 65th Annual Meeting of Orthopaedic Research Society, 2019年02月, 英語, Orthopaedic Research Society, Austin, 国際会議Influence of Adipose-derived Regenerative Cells for the Treatment of Osteoarthritis of the Kneeポスター発表
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議Anthologyステムを用いた人工股関節全置換術の短期成績口頭発表（一般）
- 第49回日本人工関節学会, 2019年02月, 日本語, 日本人工関節学会, 東京, 国内会議Anthology Hip SystemのHAコーティング有無での検討口頭発表（一般）
- 第33回日本臨床リウマチ学会, 2018年11月, 日本語, 日本臨床リウマチ学会, 東京, 国内会議関節リウマチ患者に対する追跡期間10年を超えるTNF阻害薬の治療継続率口頭発表（一般）
- 第66回神戸整形外科セミナー, 2018年11月, 日本語, 神戸整形外科セミナー, 神戸, 国内会議関節リウマチにおける、周術期感染症対策[招待有り]口頭発表（招待・特別）
- 第46回日本関節病学会, 2018年11月, 日本語, 日本関節病学会, 岡山, 国内会議簡易ナビゲーションシステムを用いたキネマティックアライメントTKAにおける脛骨骨切り精度と術後臨床成績の検討口頭発表（一般）
- 日本臨床バイオメカニクス学会, 2018年11月, 日本語, 日本臨床バイオメカニクス学会, 秋田, 国内会議いかに評価するか：臨床所見からシンポジウム・ワークショップパネル（公募）
- 第46回日本関節病学会, 2018年11月, 日本語, 日本関節病学会, 岡山, 国内会議TKA後深部感染に対する治療戦略シンポジウム・ワークショップパネル（公募）
- 日本臨床バイオメカニクス学会, 2018年11月, 日本語, 日本臨床バイオメカニクス学会, 秋田, 国内会議PS型TKAにおける術中軟部組織バランスが膝関節キネマティクスと術後屈曲角度に及ぼす影響口頭発表（一般）
- 第33回日本整形外科学会基礎学術集会, 2018年10月, 日本語, 日本整形外科学会, 奈良, 国内会議軟骨細胞においてNF-κBを介してのAQP9の抑制による異化因子の減弱ポスター発表
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議特発性大腿骨頭壊死症診療ガイドライン 保存治療シンポジウム・ワークショップパネル（公募）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議特発性大腿骨頭壊死症患者における術前術後の性別によるQOLの特徴口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議特発性大腿骨頭壊死症患者における術前後の経時的QOL評価口頭発表（一般）
- 第131回中部日本整形外科災害外科学会・学術集会, 2018年10月, 日本語, 中部日本整形外科災害外科学会, 岡山, 国内会議人工膝関節置換術後における深部感染74症例の治療成績：感染時期とメチシリン耐性菌感染の影響ポスター発表
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議人工股関節全置換術後における術式別の下肢筋力推移と歩行能力の関係性口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議人工股関節全置換術における骨盤側方傾斜角と下肢筋力回復との関係性口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議術前の股関節内局所麻酔注射の効果と股関節鏡術中所見や術後成績の予見性について口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議手術加療に至った股関節唇損傷・FAI症例の特徴とは?口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議仰臥位THAの術中の骨盤安定性に影響する因子の検討口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議仰臥位THAにおけるポータブルナビゲーションの精度評価口頭発表（一般）
- 第131回中部日本整形外科災害外科学会・学術集会, 2018年10月, 日本語, 中部日本整形外科災害外科学会, 岡山, 国内会議仰臥位THAにおけるポータブルナビゲーションの精度に及ぼすBMIの影響口頭発表（一般）
- 第33回日本整形外科学会基礎学術集会, 2018年10月, 日本語, 日本整形外科学会, 奈良, 国内会議関節リウマチ滑膜細胞におけるdecoy receptor 3によるcadherin 2発現誘導の検討ポスター発表
- 第131回中部日本整形外科災害外科学会・学術集会, 2018年10月, 日本語, 中部日本整形外科災害外科学会, 岡山, 国内会議関節リウマチの生物製剤治療におけるSNPアルゴリズムの有用性口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議寛骨臼回転骨切り術後の可動域は移動骨片の前方被覆量に影響される口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議セメントステムを使用した人工股関節全置換術後におけるステムアライメントとステム周囲の骨密度の関係口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議TriLock stem使用症例の中期成績口頭発表（一般）
- 39th SICOT Orthopaedic World Congress, 2018年10月, 英語, International Society of Orthopaedic Surgery and Traumatology, Montreal, 国際会議Trearment results of 74 deep infections after total knee arthroplasty : effects of infection timing and methicillin-resistant bacteriaポスター発表
- Annual meeting of International Society for Hip Arthroscopy 2018, 2018年10月, 英語, International Society for Hip Arthroscopy, Melbourne, 国際会議The predictive value of preoperative anesthetic hip joint injection for intra-articular pathology and hip arthroscopy outcomesポスター発表
- 39th SICOT Orthopaedic World Congress, 2018年10月, 英語, International Society of Orthopaedic Surgery and Traumatology, Montreal, 国際会議The influence of limb alignment and prosthetic orientation of patient-derived clinical outcome in total knee arthroplastyポスター発表
- 39th SICOT Orthopaedic World Congress, 2018年10月, 英語, International Society of Orthopaedic Surgery and Traumatology, Montreal, 国際会議The Evaluation of lower limb alignment with HIP-TO-CALCANEUS rasiograph after unicompartmental knee arthroplastyポスター発表
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議S-ROM stemを用いた人工股関節置換術における合併症の検討口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議Spherical Periacetabular Osteotomy(SPO)の短期成績口頭発表（一般）
- Annual meeting of International Society for Hip Arthroscopy 2018, 2018年10月, 英語, International Society for Hip Arthroscopy, Melbourne, 国際会議Relationship of morphology of hip labral tear to the clinical findings before and after hip arthroscopy口頭発表（一般）
- Annual meeting of International Society for Hip Arthroscopy 2018, 2018年10月, 英語, International Society for Hip Arthroscopy, Melbourne, 国際会議Relationship between labral tear confirmed by hip arthroscopy and preoperative imaging findingポスター発表
- The 62nd Annual Congress of the Korean Orthopaedic Association, 2018年10月, 英語, The Korean Orthopaedic Association, Seoul, 国際会議Modified kinematically aligned total knee arthroplasty.[招待有り]シンポジウム・ワークショップパネル（指名）
- 39th SICOT Orthopaedic World Congress, 2018年10月, 英語, International Society of Orthopaedic Surgery and Traumatology, Montreal, 国際会議Lessons learned from navigation- The Japanese experience[招待有り]シンポジウム・ワークショップパネル（指名）
- 第６回神緑会ヤングインベスティゲーターアワード, 2018年10月, 日本語, 神緑会, 神戸, 国内会議Decoy Receptor 3 down-regulates Centrosomal Protein 70kDa in Specifically Rheumatoid Synovial Fibroblastsポスター発表
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議Anthologyステムを用いた人工股関節全置換術の短期成績口頭発表（一般）
- 第45回日本股関節学会学術集会, 2018年10月, 日本語, 日本股関節学会学術集会, 名古屋, 国内会議Anthology Hip SystemのHAコーティング有無での検討口頭発表（一般）
- 20th Asia Pacific League of Associations for Rheumatology Congress, 2018年09月, 英語, Asia Pacific League of Associations for Rheumatology, Kaohsiung, 国際会議N-cadherin is up-regulated by Decoy Receptor 3 in Rheumatoid Synovial Fibroblastsポスター発表
- ASBMR 2018 Annual Meeting, 2018年09月, 英語, The American Society for Bone and Mineral Research, Montreal, 国際会議Denosumab treatment improves health related quality of life in patients with osteoporosisポスター発表
- 第10回日本関節鏡・膝・スポーツ整形外科学会, 2018年06月, 英語, 日本関節鏡・膝・スポーツ整形外科学会, 福岡, 国内会議The influence of intraoperative soft tissue balance on clinical outcomes especially in patient satisfaction.シンポジウム・ワークショップパネル（指名）
- Annual European Congress of Rheumalotogy - EULAR 2018, 2018年06月, 英語, European League against Rheumatic Diseases, Amsterdam, 国際会議Comparison of the retention rate of biological DMARDs ~ the data from patients with RA who were followed up for over 10 yearsポスター発表
- 第91回日本整形外科学会学術集会, 2018年05月, 日本語, 日本整形外科学会, 神戸, 国内会議骨盤骨切り術におけるnavigationの有効性ポスター発表
- 第62回リウマチ学会総会・学術集会, 2018年04月, 日本語, 日本リウマチ学会, 東京, 国内会議生物学的製剤治療中のRA患者における単純ヘルペスおよび帯状疱疹ヘルペス発症に関わる遺伝子多型性の検討シンポジウム・ワークショップパネル（公募）
- 第62回リウマチ学会総会・学術集会, 2018年04月, 日本語, 日本リウマチ学会, 東京, 国内会議生物学的製剤の治療継続率の比較-追跡期間10年を超える症例を対象とする-ポスター発表
- 第62回リウマチ学会総会・学術集会, 2018年04月, 日本語, 日本リウマチ学会, 東京, 国内会議関節リウマチ患者における関節破壊進行の予測はSNPｓ解析で可能である-多施設コホート研究-シンポジウム・ワークショップパネル（公募）
- 第62回リウマチ学会総会・学術集会, 2018年04月, 日本語, 日本リウマチ学会, 東京, 国内会議関節リウマチ滑膜細胞におけるCadherin 2の発現はDecoy receptor 3により誘導されるシンポジウム・ワークショップパネル（公募）
- 第130回中部日本整形外科災害外科学会・学術集会, 2018年04月, 日本語, 中部日本整形外科災害外科学会, 松山, 国内会議ウサギ関節症モデルにおける脂肪由来再生幹細胞自家移植の治療効果についての検討口頭発表（一般）
- 第130回中部日本整形外科災害外科学会・学術集会, 2018年04月, 日本語, 中部日本整形外科災害外科学会, 松山, 国内会議RA患者においてデノスマブによる骨粗鬆症治療は患者QOLを改善するポスター発表
- The 64th Annual Meeting of the Orthopaedic Research Society, 2018年03月, 英語, The Orthopaedic Research Society, New Orleans, USA, 国際会議Therapeutic effects of autologous adipose derived regenerative cells for osteoarthritis in an experimental rabbit modelポスター発表
- The 64th Annual Meeting of the Orthopaedic Research Society, 2018年03月, 英語, The Orthopaedic Research Society, New Orleans, USA, 国際会議The Influence of Gelatin Hydrogel Including Eicosapentaenoic Acid on the Osteoarthritis Progression in Vivo口頭発表（一般）
- The 64th Annual Meeting of the Orthopaedic Research Society, 2018年03月, 英語, The Orthopaedic Research Society, New Orleans, USA, 国際会議The effect of transcutaneous application of carbon dioxide on postoperative pain relief after total knee arthroplastyポスター発表
- The 64th Annual Meeting of the Orthopaedic Research Society, 2018年03月, 英語, The Orthopaedic Research Society, New Orleans, USA, 国際会議Intraoperative soft tissue balance/kinematics and clinical evaluation of kinematically versus mechanically aligned total knee arthroplasty口頭発表（一般）
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議単顆型人工膝関節置換術における脛骨implant orientation angleの検討口頭発表（一般）
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議人工膝関節全置換術後における深部感染74症例の治療成績 感染時期とメチシリン耐性菌感染の影響口頭発表（一般）
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議ステム前捻角を過度にコントロールすると術後大腿骨近位の骨密度が低下するポスター発表
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議キネマティックアライメント法によるTKAの機種間による相違ポスター発表
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議UKAにおける脛骨後方傾斜角度の術中評価は正解か?ポスター発表
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議Taper wedge型ステム2機種におけるレントゲン評価の比較口頭発表（一般）
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議Revision THA後のADL・QOL・満足度に影響する術前因子についての検討口頭発表（一般）
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議Bi-cruciate stablized TKAにおける術中kinematicsと患者立脚型評価ポスター発表
- 第48回日本人工関節学会, 2018年02月, 日本語, 日本人工関節学会, 東京, 国内会議Anterolateral-supine approachによる人工股関節全置換術における白蓋カップ設置の正確性とリスク因子口頭発表（一般）
- 第45回日本関節病学会, 2017年11月, 日本語, 日本関節病学会, 東京, 国内会議キネマティックアライメント法によるTKAの術中軟部組織バランス・キネマティクス評価口頭発表（一般）
- 第44回日本臨床バイオメカニクス学会, 2017年11月, 日本語, 日本臨床バイオメカニクス学会, 松山, 国内会議キネマティックアライメント法によるTKAの術中軟部組織バランス・キネマティクス評価口頭発表（一般）
- 第44回日本臨床バイオメカニクス学会, 2017年11月, 日本語, 日本臨床バイオメカニクス学会, 松山, 国内会議mobile-bearing TKA とfixed-bearing TKAの大腿脛骨間回旋角度と膝蓋大腿関節圧の比較検討口頭発表（一般）
- 第45回日本関節病学会, 2017年11月, 日本語, 日本関節病学会, 東京, 国内会議HIP-to calcaneus radiographによる単顆型人工膝関節置換術術後下肢アライメント評価口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議特発性大腿骨頭壊死症患者の就業の実態とQOLの特徴口頭発表（一般）
- 第44回日本股関節学会, 2017年10月, 日本語, 国内会議特発性大腿骨頭壊死症患者の就業の実態とQOLの特徴口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議特発性大腿骨頭壊死症の病期・病型分類とQOLの関係口頭発表（一般）
- 第44回日本股関節学会, 2017年10月, 日本語, 国内会議特発性大腿骨頭壊死症の病期・病型分類とQOLの関係口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議大腿骨髄腔形状とstem周囲の骨密度の変化および影響を与える因子ポスター発表
- 第32回日本整形外科学会基礎学術集会, 2017年10月, 日本語, 日本整形外科学会, 沖縄, 国内会議前十字靱帯損傷後の遺残組織の形態の差異が治癒特性に与える影響ポスター発表
- 第32回日本整形外科学会基礎学術集会, 2017年10月, 日本語, 日本整形外科学会, 沖縄, 国内会議正常ヒト関節軟骨細胞におけるAQP9の機能解析口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議人工股関節全置換術（THA)術後にポリエチレンライナーの脱転を認めた1例口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議人工股関節全置換術における骨盤側方傾斜角とQOLの関係性口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議術前評価から考える股関節唇縫合術の適応と手術手技シンポジウム・ワークショップパネル（公募）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議骨盤骨切り術におけるナビゲーション使用による精度評価口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議寛骨臼側骨欠損に対しKTプレートと塊状同種骨を使用した人工股関節置換術の短期成績口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議エクセターショートステムの使用経験口頭発表（一般）
- 第129回中部日本整形外科災害外科学会・学術集会, 2017年10月, 日本語, 中部日本整形外科災害外科学会, 富山, 国内会議TKAにおける術後アライメントと患者立脚型臨床成績との関連性口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議Taper wedge型ステム2機種におけるレントゲン評価の比較口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議Summit stem使用症例の中期成績口頭発表（一般）
- 第32回日本整形外科学会基礎学術集会, 2017年10月, 日本語, 日本整形外科学会, 沖縄, 国内会議OA軟骨における、アクアポリン1の発現および機能解析ポスター発表
- 19th Asia Pacific League of Associations for Rheumatology Congress, 2017年10月, 英語, Dobai, UAE, 国際会議Nitric Oxide Accelerates Cell Proliferation by Preventing BIK Expression in Rheumatoid Arthritis Synoviumポスター発表
- 第129回中部日本整形外科災害外科学会・学術集会, 2017年10月, 日本語, 中部日本整形外科災害外科学会, 富山, 国内会議Decoy receptor 3は関節リウマチ滑膜細胞におけるCentrosomal protein70kDaの発現を抑制する口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議Anterolateral-supine approachによる人工股関節全置換術における臼蓋コンポーネント設置の正確性とリスク因子口頭発表（一般）
- 第44回日本股関節学会学術集会, 2017年10月, 日本語, 日本股関節学会, 東京, 国内会議ALSアプローチにおけるステム操作時に前捻角をより正確に挿入するための検討口頭発表（一般）
- 第9回日本関節鏡・膝・スポーツ整形外科学会, 2017年06月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 札幌, 国内会議FAIに対する股関節鏡視下手術の適応と実際シンポジウム・ワークショップパネル（公募）
- 17th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, 2017年06月, 英語, Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery, Aachen, Germany, 国際会議Changing Anatomic Version Causes Loss of Peri-Prosthetic Bone Density After THA口頭発表（一般）
- 第90回日本整形外科学会学術集会, 2017年05月, 日本語, 日本整形外科学会, 仙台, 国内会議単顆型人工膝関節置換術におけるhip-knee-cal-caneus angleによる下肢アライメント評価ポスター発表
- 第90回日本整形外科学会学術集会, 2017年05月, 日本語, 日本整形外科学会, 仙台, 国内会議再置換術後の日常活動性に影響する術前因子の検討ポスター発表
- 第128回中部日本整形外科災害外科学会・学術集会, 2017年04月, 日本語, 中部日本整形外科災害外科学会, 神戸, 国内会議術後の陳旧性膝蓋腱断裂と関節不安定性に対しre-revision TKAにBardmeshによる伸展機構再建を併用した1例口頭発表（一般）
- 第61回日本リウマチ学会, 2017年04月, 日本語, 福岡, 国内会議リウマチ滑膜の低ミトコンドリア生合成は滑膜増殖を亢進させ関節破壊の誘導に寄与する口頭発表（一般）
- 第128回中部日本整形外科災害外科学会・学術集会, 2017年04月, 日本語, 中部日本整形外科災害外科学会, 神戸, 国内会議TKAにおける目指すべきアライメントとは?公開講演，セミナー，チュートリアル，講習，講義等
- 第11回日本CAOS研究会, 2017年03月, 日本語, 日本CAOS研究会, 新潟, 国内会議過度な前捻コントロールは術後ストレスシールディングを引き起こす口頭発表（一般）
- 第11回日本CAOS研究会, 2017年03月, 日本語, 日本CAOS研究会, 新潟, 国内会議ナビゲーションシステムを使用したキネマティックアライメント法によるTKAの臨床成績口頭発表（一般）
- 第30回日本軟骨代謝学会, 2017年03月, 日本語, 日本軟骨代謝学会, 京都, 国内会議The study of AQP9 in the normal human articular chondrocytes.口頭発表（一般）
- 第30回日本軟骨代謝学会, 2017年03月, 日本語, 日本軟骨代謝学会, 京都, 国内会議OA 軟骨において、アクアポリン1はMAPK 経路を介してADAMTS-4 の発現を調節している口頭発表（一般）
- The Orthopaedic Research Society 2017 Annual Meeting, 2017年03月, 英語, Orthopaedic Research Society, サンディエゴ, アメリカ合衆国, 国際会議Enhancement of mitochondrial biogenesis inhibits cell proliferation by inducing internal apoptosis of rheumatoid arthritis fibroblast-like synovial cell and joint destruction of an arthritis model miceポスター発表
- The 63rd Annual Meeting of the Orthopaedic Research Society, 2017年03月, 英語, The Orthopaedic Research Society, San Diego, USA, 国際会議Cyclin-dependent kinase inhibitor-1 deficiency increases susceptibility to osteoarthritis with inflammationポスター発表
- 第11回日本CAOS研究会, 2017年03月, 日本語, 日本CAOS研究会, 新潟, 国内会議CT-free navigation systemを使用したTKAの患者立脚型中期臨床成績口頭発表（一般）
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議同一術者による短外旋筋群温存ALSアプローチにおけるステムの違いが前捻角に与える影響口頭発表（一般）
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議人工膝関節全置換術における異なるtensor systemでの術中軟部組織バランスの比較ポスター発表
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議再置換術後日常活動性に影響する因子口頭発表（一般）
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議ステム周囲のX線学的骨萎縮評価と骨密度との関連性ポスター発表
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議キネマティックアライメント法によるTKAのX線評価と臨床成績口頭発表（一般）
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Tri-Lock BPS stem使用症例における髄腔形状と成績の関係ポスター発表
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Tapered Wedge型ステムにおけるHAコーティングが早期固着に与える影響ポスター発表
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Hip-knee-calcaneus angleによる単顆型人工膝関節置換術術後下肢アライメント評価口頭発表（一般）
- 第47回日本人工関節学会, 2017年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Anthology Hip SystemのDEXAによる術後2年の骨密度変化の検討ポスター発表
- 第6回DDS再生医療研究会, 2016年12月, 日本語, DDS再生医療研究会, 神戸, 国内会議エイコサペンタエン酸徐放ゲルは変形性関節症の進行を抑制する口頭発表（一般）
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議人工股関節全置換術後のstem周囲の骨密度に影響を与える因子の検討ポスター発表
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議再置換術後の日常活動性に影響する因子の検討口頭発表（一般）
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議股関節唇損傷形態から考察する股関節鏡視下手術の適応その他
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議ステム周囲のX線学的骨萎縮評価と骨密度との関連性ポスター発表
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議インプラント形状の違いによる骨頭部の回旋抑制性に与える影響口頭発表（一般）
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議SMFショートステムの設置アライメントと使用経験ポスター発表
- 第43回日本股関節学会, 2016年11月, 日本語, 日本股関節学会, 大阪, 国内会議Anthology stemにおける術後短期のステム周囲骨密度の検討～HAコーティングの効果について～ポスター発表
- 第17回日本骨粗鬆症学会, 2016年10月, 日本語, 日本骨粗鬆症学会, 仙台, 国内会議人工股関節置換術後のステム周囲の骨密度は術後の活動性と相関する口頭発表（一般）
- 第3回アニュアルコースレクチャー, 2016年10月, 日本語, 日本リウマチ学会, 東京, 国内会議リウマチ滑膜細胞のアポトーシス抵抗性とミトコンドリア機能ポスター発表
- 第31回日本整形外科学会基礎学術集会, 2016年10月, 日本語, 日本整形外科学会, 福岡, 国内会議ミトコンドリア生合成亢進がリウマチ滑膜の細胞増殖と関節破壊に与える影響口頭発表（一般）
- 第31回日本整形外科学会基礎学術集会, 2016年10月, 日本語, 日本整形外科学会, 福岡, 国内会議エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制する口頭発表（一般）
- 第31回日本整形外科学会基礎, 2016年10月, 日本語, 日本整形外科学会, 福岡, 国内会議The study of AQP9 in the normal human articular chondrocytes.ポスター発表
- 29th Annual Congress of the International Society for Technology in Arthroplasty, 2016年10月, 英語, International Society for Technology in Arthroplasty, Boston, USA, 国際会議Excessive Stem Version Control Causes Stress Shielding After Total Hip Arthroplasty.ポスター発表
- 第12回日本股関節鏡研究会, 2016年09月, 日本語, 日本股関節鏡研究会, 浜松, 国内会議股関節に生じたpigmented villonodular synovitis（PVNS）に対し股関節鏡を用いて治療を行った一例口頭発表（一般）
- The 8th International Society for Hip Arthroscopy Annual Scientific Meeting, 2016年09月, 英語, International Society for Hip Arthroscopy, San Francisco , USA, 国際会議The Pathology of hip labrum and chondrolabral junction varies with radiographic parameters.口頭発表（一般）
- 第8回日本関節鏡・膝・スポーツ整形外科学会, 2016年07月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 福岡, 国内会議大腿骨頭離断性骨軟骨炎に対してRAO、骨軟骨柱移植術を施行したアメリカンフットボール選手の1例.口頭発表（一般）
- 第37回日本炎症・再生学会, 2016年06月, 日本語, 日本炎症・再生学会, 京都, 国内会議エイコサペンタエン酸は軟骨細胞の変性と変形性関節症の進行を抑制するポスター発表
- 第89回日本整形外科学会学術総会, 2016年05月, 日本語, 日本整形外科学会学術総会, 横浜, 国内会議単純X線像における股関節鏡視下手術の適応と限界その他
- 第89回日本整形外科学会学術総会, 2016年05月, 日本語, 日本整形外科学会, 横浜, 国内会議術前の変形性足関節症の病期は人工足関節置換術後の成績に影響があるか?ポスター発表
- 第60回日本リウマチ学会学術集会, 2016年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議ミトコンドリア生合成の亢進はコラーゲン誘導性関節炎(CIA)マウスの関節破壊を抑制するポスター発表
- 第46回日本人工関節学会, 2016年02月, 日本語, 日本人工関節学会, 大阪, 国内会議運動量と腰椎骨密度はステム周囲骨密度と相関するポスター発表
- Orthopaedic Research Society 62nd Annual Meeting 2016, 2016年02月, 英語, Orthopaedic Reserch Society, Orlando, USA, 国際会議The aquaporin1 water channel expression in human articular chondrocytesis related with inflammationポスター発表
- 第46回日本人工関節学会, 2016年02月, 日本語, 日本人工関節学会, 大阪, 国内会議Summit stem使用症例の中期成績ポスター発表
- 第29回日本軟骨代謝学会, 2016年02月, 日本語, 日本軟骨代謝学会, 広島, 国内会議p21欠損は炎症による変形性関節症を加速させる口頭発表（一般）
- Orthopaedic Research Society 62nd Annual Meeting 2016, 2016年02月, 英語, Orthopaedic Reserch Society, Orlando, USA, 国際会議p21 deficiency is susceptible to osteoarthritis with inflammation口頭発表（一般）
- 第29回日本軟骨代謝学会, 2016年02月, 日本語, 日本軟骨代謝学会, 広島, 国内会議Aquaporin1 water channel expression in human articular chondrocytesポスター発表
- 第46回日本人工関節学会, 2016年02月, 日本語, 人工関節学会, 大阪, 国内会議Anthology Hip SystemのDEXAによる術後骨密度変化の検討ポスター発表
- 第37回日本バイオマテリアル学会大会, 2015年11月, 日本語, 日本バイオマテリアル学会, 京都, 国内会議エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞の変性、アポトーシスを抑制するポスター発表
- 第42回日本股関節学会, 2015年10月, 日本語, 国内会議股関節疾患のQOL評価の活用法, 各種スコアの比較口頭発表（招待・特別）
- 第2回JCRベーシックリサーチカンファレンス, 2015年10月, 日本語, 日本リウマチ学会, 東京, 国内会議関節リウマチ滑膜細胞のミトコンドリア機能低下は関節破壊を促進させるポスター発表
- 第42回日本股関節学会学術集会, 2015年10月, 日本語, 日本股関節学会, 大阪, 国内会議運動量と腰椎骨密度はステム周囲骨密度と相関する口頭発表（一般）
- 第42回日本股関節学会学術集会, 2015年10月, 日本語, 日本股関節学会, 大阪, 国内会議ステム前稔アライメントは術後ステム周囲骨密度に影響する口頭発表（一般）
- 第30回日本整形外科学会基礎学術集会, 2015年10月, 日本語, 日本整形外科学会, 富山, 国内会議p21欠損は炎症による変形性関節症を加速させるポスター発表
- 第42回日本股関節学会学術集会, 2015年10月, 日本語, 日本股関節学会, 大阪, 国内会議Kerboull型プレートを用いた人工股関節再置換術の術後成績に影響する因子の検討口頭発表（一般）
- The 28th Annual Congress of International Society for Technology in Arthroplasty., 2015年09月, 日本語, The International Society for Technology in Arthroplasty, Vienna, Austria, 国際会議Risk Factor for Failure of Revision Total Hip Arthroplasty Using a Kerboull-Type Acetabular Reinforcement Device.口頭発表（一般）
- The 28th Annual Congress of International Society for Technology in Arthroplasty., 2015年09月, 日本語, The International Society for Technology in Arthroplasty, Vienna, Austria, 国際会議Daily Activity and Initial Spine Bone Mineral Density Are Associated With Periprosthetic Bone Mineral Density After Total Hip Arthroplasty With a Tapered-Wedge Stem.口頭発表（一般）
- 第7回日本関節鏡・膝・スポーツ整形外科学会, 2015年06月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 札幌, 国内会議距骨外側突起骨折後及び腓骨外果骨折後の遺残変形に対する足部内視鏡手術口頭発表（一般）
- The 16th Annual European Congress of Rheumatology, 2015年06月, 英語, The European League Against Rheumatism, Rome, Italy, 国際会議p21 deficiency was susceptible to osteoarthritis with inflammation.口頭発表（一般）
- 第7回日本関節鏡・膝・スポーツ整形外科学会, 2015年06月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 札幌, 国内会議AAIS、PAIS以外の足部インピンジメント症候群に対する足部内視鏡施術シンポジウム・ワークショップパネル（公募）
- 第52回日本リハビリテーション医学会学術集会, 2015年05月, 日本語, 日本リハビリテーション医学会, 新潟, 国内会議Ｔｒｉ-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討ポスター発表
- 第52回日本リハビリテーション医学会学術集会, 2015年05月, 日本語, 日本リハビリテーション医学会, 新潟, 国内会議様々な病態が重なり整復不能となった長腓骨筋腱脱臼の1例ポスター発表
- 第52回日本リハビリテーション医学会学術集会, 2015年05月, 日本語, 日本リハビリテーション医学会, 新潟, 国内会議筋損傷後の治癒過程におけるｐ21の役割口頭発表（一般）
- 第52回日本リハビリテーション医学会学術集会, 2015年05月, 日本語, 日本リハビリテーション医学会, 新潟, 国内会議デノスマブによる骨粗鬆症の治療効果口頭発表（一般）
- 2016 Annual Meeting of the Asia-Pacific Knee, Arthroscopy and Sports Medicine Society, 2015年05月, 日本語, Ｔhe Asia-Pacific Knee, Arthroscopy and Sports Medicine Society, 台北, 台湾, 国際会議Endoscopic Treatment for deformity after lateral talar process fractureポスター発表
- 第59回日本リウマチ学会総会・学術集会, 2015年04月, 日本語, 日本リウマチ学会, 名古屋, 国内会議RA滑膜細胞のミトコンドリア活性化は細胞増殖とMMP-3/RANKLの分泌を抑制するポスター発表
- 第19回兵庫股関節研究会プログラム, 2015年03月, 日本語, 兵庫股関節研究会, 神戸, 国内会議Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討口頭発表（一般）
- 第28回日本軟骨代謝学会, 2015年03月, 日本語, 日本軟骨代謝学会, 東京, 国内会議p21欠損は炎症による変形性関節症を加速させる口頭発表（一般）
- The 61th Annual Meeting of the Orthopaedic Research Society, 2015年03月, 英語, Orthopaedic Research Society, Las Vegas, USA, 国際会議p21 Deficiency Impaired The Regeneration of Skeletal Muscleポスター発表
- The 61th Annual Meeting of the Orthopaedic Research Society, 2015年03月, 英語, Orthopaedic Research Society, Las Vegas, USA, 国際会議Oxidative Stress-induced ApoptosisAnd Matrix Loss Of Chondrocytes IsInhibited By Eicosapentaenoic Acid口頭発表（一般）
- The 61th Annual Meeting of the Orthopaedic Research Society, 2015年03月, 英語, Orthopaedic Research Society, Las Vegas, USA, 国際会議Molecular Characteristics Proving FemoroacetabularImpingement As The Precursor To Hip Osteoarthritisポスター発表
- 2015 Annual Meeting of the Orthopaedic Research Society, 2015年03月, 英語, The Orthopaedic Research Sosiety, Las Vegas, USA, 国際会議Centrosomal Protein 70kda Is Down-regulatedBy Decoy Receptor 3 In Specifically RheumatoidSynovial Fibroblastsポスター発表
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議大腿骨側ステムのアライメントはステムデザインにより影響を受けるないポスター発表
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議人工足関節置換術において術前可動域は術後可動域に影響を与えるか?口頭発表（一般）
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討ポスター発表
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議THAにおける手術進入路の違いが術後可動域に与える影響口頭発表（一般）
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議Summit stem使用症例の4年成績ポスター発表
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議Kerboull型プレートを用いた人工股関節再置換術の術後成績口頭発表（一般）
- 第45回日本人工関節学会, 2015年02月, 日本語, 日本人工関節学会, 福岡, 国内会議60才未満に対する人工股関節全置換術後のADLと職場復帰についてポスター発表
- 第41回日本臨床バイオメカニクス学会, 2014年11月, 日本語, 日本臨床バイオメカニクス学会, 奈良, 国内会議MDCT画像を用いたTHAカップ設置角度計測法と再現性評価口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議大腿骨側ステムのアライメントはステムデザインにより影響を受ける口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議若年者に対するTHA前後の骨盤アライメントが下肢筋発揮効率に影響を与えた1症例口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 国内会議在宅患者の運動継続支援へのICTの有効活用―運動療法webでの双方向的なコメント分析―口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議股関節唇損傷症例におけるX線学的指標・臨床所見・関節軟骨損傷の関連口頭発表（一般）
- 第29回日本整形外科学会基礎学術集会, 2014年10月, 日本語, 日本整形外科学会, 鹿児島, 国内会議筋損傷後の治癒過程におけるp21の役割口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議Tri-Lock Bone Preservation StemのDEXAによる術後骨密度変化の検討口頭発表（一般）
- The 11th Congress of European Hip Society, 2014年10月, 英語, European Hip Society, Stockholm, Sweden, 国際会議The diagnostic potential of biochemical MRI for articular cartilage damage of femoroacetabular impingement.ポスター発表
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議THAにおける手術進入路は術後可動域に影響するか-同一術者による後方と前側方、前方アプローチの比較-口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議THAにおける手術進入路はインプラント設置角度に影響するか-同一術者による後方と前側方アプローチの比較-口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議Summit stem使用症例の4年成績口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 国内会議painDETECTによる股関節疾患患者の神経障害性疼痛の実態調査ポスター発表
- The 11th Congress of European Hip Society, 2014年10月, 英語, European Hip Society, Stockholm, Sweden, 国際会議Molecular characteristic of the tissues from hips with femoroacetabular impingement.ポスター発表
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議Kerboull型プレートを用いた人工股関節再置換術の術後成績口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議FAIの分子生物学的特徴口頭発表（一般）
- 第41回日本股関節学会学術集会, 2014年10月, 日本語, 日本股関節学会, 東京, 国内会議3Dテンプレートソフトを用いたエクセターステムの設置評価口頭発表（一般）
- 第6回日本関節鏡・膝・スポーツ整形外科学会, 2014年07月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 広島, 国内会議人工足関節置換術の現状と未来[招待有り]シンポジウム・ワークショップパネル（指名）
- 第51回日本リハビリテーション医学会学術集会, 2014年06月, 日本語, 日本リハビリテーション医学会, 名古屋, 国内会議有症性の両側第4腓骨筋腱に対する治療経験ポスター発表
- 第51回日本リハビリテーション医学会学術集会, 2014年06月, 日本語, 日本リハビリテーション医学会, 名古屋, 国内会議距骨に骨軟骨腫を生じた一例ポスター発表
- 第51回日本リハビリテーション医学会学術集会, 2014年06月, 日本語, 日本リハビリテーション医学会, 名古屋, 国内会議G2ステム使用症例の短中期成績ポスター発表
- 14th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, 2014年06月, 英語, International Society for Computer Assisted Orthopaedic Surgery, Milano, Italy, 国際会議Accuracy of three-dimensional preoperative templating in total hip arthroplasty using navigation.ポスター発表
- 14th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, 2014年06月, 英語, International Society for Computer Assisted Orthopaedic Surgery, Milano, Italy, 国際会議Accuracy of stem alignment is affected by stem design and surgical approach.ポスター発表
- 第87回日本整形外科学会学術集会, 2014年05月, 日本語, 日本整形外科学会, 神戸, 国内会議足関節以外の足部インピンジメント症候群に対する足部内視鏡手術口頭発表（一般）
- 第49回日本理学療法学術大会, 2014年05月, 日本語, 日本理学療法士協会, 横浜, 国内会議ディシジョンツリー分析を用いた人工股関節全置換術後在院日数予測モデルの構築(第2報)口頭発表（一般）
- 第87回日本整形外科学会学術総会, 2014年05月, 日本語, 日本整形外科学会, 神戸, 国内会議Kerboull型プレートを用いた人工股関節再置換術の術後成績シンポジウム・ワークショップパネル（公募）
- 第87回日本整形外科学会学術集会, 2014年05月, 日本語, 日本整形外科学会, 神戸, 国内会議Femoroacetabular impingementに対する画像診断口頭発表（一般）
- OARSI, 2014年04月, 日本語, 国際会議Remote assessments and instructions for home-rehabilitation via custom-made website in patients with hip and knee osteoarthritis; A preliminary report. World congress on osteoarthritisポスター発表
- The 60th Annual Meeting of Orthopaedic Research Society, 2014年03月, 英語, Orthopaedic Research Society, New Orleans, USA, 国際会議PTEN Regulates Matrix Synthesis in Adult HumanChondrocytes under Oxidative Stressポスター発表
- The 60th Annual Meeting of Orthopaedic Research Society, 2014年03月, 英語, Orthopaedic Research Society, New Orleans, USA, 国際会議P21 Regulates Mmp-13 Expression Through Stat3 Signaling In Chondrocytesポスター発表
- The 60th Annual Meeting of Orthopaedic Research Society, 2014年03月, 英語, Orthopaedic Research Society, New Orleans, USA, 国際会議Cyclin-dependent Kinase Inhibitor, P21 Is Not Essential For Endochondral Ossificationポスター発表
- 第87回日本整形外科学会学術総会, 2014年03月, 日本語, 日本整形外科学会, 神戸, 国内会議CT-based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置精度における検討口頭発表（一般）
- 第8回日本CAOS研究会, 2014年03月, 日本語, 日本CAOS研究会, 横浜, 国内会議3Dテンプレートによる術前予定ステムサイズと術中選択サイズの検討口頭発表（一般）
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Ｇ2ステム使用症例の短中期成績ポスター発表
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議ＡＲＭＤにより臼蓋コンポーネント周囲に巨大な骨欠損を生じた1例ポスター発表
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議手術アプローチの違いによるTHA術後可動域における検討口頭発表（一般）
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議高位脱臼股に対するセメントレス人工股関節全置換術の臨床成績ポスター発表
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議アルミセラミック骨頭の破損をきたしたセラミック人工股関節の1例ポスター発表
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議TNK人工足関節置換術後の足関節可動域についての検討口頭発表（一般）
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議RA患者におけるＴＨＡ術後の遅発性感染の要因－生物学製剤はリスクファクターになりうるか－口頭発表（一般）
- 第44回日本人工関節学会, 2014年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議3Ｄテンプレートによる術前予定ステムサイズと術中選択サイズの検討口頭発表（一般）
- The Asian Pacific Hip Arthroscopy Meeting 2014., 2014年01月, 英語, The Asian Pacific Hip Arthroscopy Meeting, 北九州, 国際会議The diagnostic potential of biochemical MRI for articular cartilage damage of femoroacetabular impingement.口頭発表（一般）
- The Asia Pacific Hip Arthroscopy Meeting 2014, 2014年01月, 英語, The Asia Pacific Hip Arthroscopy, 北九州, 国際会議Molecular characteristic of the tissues from hips with femoroacetabular impingement口頭発表（一般）
- 第40回日本股関節学会学術集会, 2013年11月, 日本語, 日本股関節学会, 広島, 国内会議ＲＡ患者におけるＴＨＡ術後の遅発性感染の要因-生物学製剤はリスクファクターになりうるのか口頭発表（一般）
- 第40回日本股関節学会学術集会, 2013年11月, 日本語, 日本股関節学会, 広島, 国内会議人工股関節置換術後患者の公共交通機関利用の不安と困難について口頭発表（一般）
- 第40回日本股関節学会学術集会, 2013年11月, 日本語, 日本股関節学会, 広島, 国内会議summit使用症例の短期成績口頭発表（一般）
- The 5th Scientific Meeting of Asian Federation of Foot and Ankle Surgeons, 2013年11月, 英語, The Asian Federation of Foot and Ankle Surgeons, 香港, 中国, 国際会議Fixation of osteochondral lesions of the talus using bone pegs: a report of two casesポスター発表
- 第40回日本股関節学会学術集会, 2013年11月, 日本語, 日本股関節学会, 広島, 国内会議3Ｄテンプレートソフトを用いたZweymuller型ステムの固定様式の検討口頭発表（一般）
- 第38回日本足の外科学会・学術集会, 2013年10月, 日本語, 日本足の外科学会, 仙台, 国内会議距骨に骨軟骨腫を生じた一例ポスター発表
- 第28回日本RAのリハビリ研究会学術集会, 2013年10月, 日本語, 日本RAのリハビリ研究会, 神戸, 決定木分析を用いてTHA患者の検討を行い、ＲＡ患者における逸脱要因を検討した, 国内会議関節リウマチ患者に対する人工股関節全置換術後在院日数予測モデルの逸脱要因～ディシジョンツリー分析を用いた検討～口頭発表（一般）
- 第28回日本整形外科学会基礎学術集会, 2013年10月, 日本語, 日本整形外科学会基礎学術集会, 千葉, 国内会議ヒト軟骨細胞においてPTENは酸化ストレス下に基質の産生を調整する口頭発表（一般）
- 第38回日本足の外科学会・学術集会, 2013年10月, 日本語, 日本足の外科学会, 仙台, 国内会議カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例ポスター発表
- 第28回日本整形外科学会基礎学術集会, 2013年10月, 日本語, 日本整形外科学会基礎学術集会, 千葉, 国内会議エイコサペンタエン酸はストレス依存性の軟骨細胞の変性、アポトーシスを抑制する口頭発表（一般）
- 第38回日本足の外科学会学術集会, 2013年10月, 日本語, 日本足の外科学会, 仙台, 国内会議TNK人工足関節置換術後の足関節可動域についての検討口頭発表（一般）
- The Annual Meeting of 2013 International Society for Technology in Arthroplasty, 2013年10月, 英語, The International Society for Technology in Arthroplasty, Palm Beach, USA, 国際会議Excessive femoral offset does not affect the range of motion after total hip arthroplastyポスター発表
- The Annual Meeting of 2013 International Society for Hip Arthroscopy, 2013年10月, 英語, The International Society for Hip Arthroscopy, Munich, Deutschland, 国際会議Detection of articular cartilage damage with T1 rho MRI on FAI patientsポスター発表
- The 11th world Congress of the International Cartilage Repair Society, 2013年09月, 英語, The International Cartilage Repair Society, Izmir, Republic of Turkey, 国際会議Fixation of osteochondral lesions of the talus using bone pegs: a report of two casesポスター発表
- 第5回 日本関節鏡・膝・スポーツ整形外科学会（JOSKAS）, 2013年06月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 札幌, 国内会議カシンベック病に伴う変形性足関節症に対し鏡視下足関節固定術をおこなった症例ポスター発表
- 第5回 日本関節鏡・膝・スポーツ整形外科学会, 2013年06月, 日本語, 日本関節鏡・膝・スポーツ整形外科学会, 札幌, 国内会議Femoroacetabular Impingementにおける関節軟骨に対するT1rho MRIの診断意義口頭発表（一般）
- 第86回日本整形外科学会学術総会, 2013年05月, 日本語, 日本整形外科学会, 広島, 国内会議変形性股関節症に対するChiari骨盤骨切り術の長期成績口頭発表（一般）
- 第86回日本整形外科学会, 2013年05月, 日本語, 日本整形外科学会, 広島, 国内会議人工股関節術後でのエドキサバン投与の有効性と安全性ポスター発表
- The 2013 Annual meeting of osteoarthritis research international, 2013年04月, 英語, osteoarthritis research international, Philadelphia, USA, 国際会議PTEN regulates the expressions of typeII collagen and aggrecan under oxidative stress in human chondrocytesポスター発表
- The Annual Meeting of 2013 Osteoarthritis Research Society International, 2013年04月, 英語, The Osteoarthritis Research Society International, Philadelphia, USA, 国際会議p21 regulates MMP-13 expression via STAT3 signaling in chondrocytes.口頭発表（一般）
- The 2013 Annual meeting of osteoarthritis research international, 2013年04月, 英語, osteoarthritis research international, Philadelphia, USA, 国際会議Eicosapentaenoic acid reduced chondrocytes apoptosis by oxidative stress口頭発表（一般）
- 第26回日本軟骨代謝学会, 2013年03月, 日本語, 日本軟骨代謝学会, 大阪, エイコサペンタエン酸は、軟骨細胞変性、アポトーシスを抑制し、変形性関節症治療に有用である可能性がある, 国内会議エイコサペンタエン酸は酸化ストレス依存性の軟骨細胞のアポトーシス口頭発表（一般）
- 第43回日本人工関節学会, 2013年02月, 日本語, 日本人工関節学会, 京都, 人工股関節全置換術症例におけるエドキサバンのDVT予防効果を報告した。, 国内会議人工股関節置換術後患者におけるエドキサバン投与の有用性と安全性口頭発表（一般）
- 第43回日本人工関節学会, 2013年02月, 日本語, 日本人工関節学会, 京都, 運動誘発電位モニタリングを併用した人工股関節再置換術を検討した, 国内会議運動誘発電位モニタリングを併用した人工股関節再置換術ポスター発表
- 第26回軟骨代謝学会, 2013年02月, 日本語, 軟骨代謝学会, 大阪, PTENはメカニカルストレス存在下に軟骨基質産生を調節する。, 国内会議ヒト軟骨細胞においてPTENは酸化ストレス下でII型コラーゲンとアグリカンの発現を調整する口頭発表（一般）
- 第43回日本人工関節学会, 2013年02月, 日本語, 日本人工関節学会, 京都, CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度, 国内会議CT based fluoroscopic matching navigation systemを使用したTHAの大腿骨コンポーネント設置角度の精度分析口頭発表（一般）
- 59th Annual Meeting of the Orthopaedic Research Society, 2013年01月, 英語, OrthopaedicResearch Society, San Antonio, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, 国際会議p21 regulates MMP-13 expression via STAT3signaling in chondrocytesポスター発表
- 59th Annual Meeting of the Orthopaedic Research Society, 2013年01月, 英語, Orthopaedic Research Society, San Antonio, p53R2はメカニカルストレス存在下でAKTを介して基質産生を調節する。, 国際会議AKT Phosphrylation in Human Chondrocytes is Regulatedby P53R2 In Response to Mechanical Stressポスター発表
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 変形性股関節症患者の運動療法介入前後におけるHealth related quality of life 評価, 国内会議変形性股関節症患者の運動療法介入前後におけるHealth related quality of life 評価～メンタルヘルスに着目して～ポスター発表
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 変形性股関節症患者の運動療法介入におけるセルフエフィカシーの変化を検討した, 国内会議変形性股関節症患者の運動療法介入におけるセルフエフィカシーの変化口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 肥満とインプラントインピンジメントとの関係, 国内会議肥満とインプラントインピンジメントとの関係口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 前・初期股関節症に対するChiari骨盤骨切り術の術後成績を検討した。, 国内会議前・初期股関節症に対するChiari骨盤骨切り術の術後成績口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 人工股関節全置換術症例におけるエドキサバンのDVT予防効果を報告した。, 国内会議人工股関節置換術後でのエドキサバン投与の有用性と安全性口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 人工股関節全置換術症例におけるレントゲン学的FAIの存在頻度を検討した。, 国内会議人工股関節全置換術症例におけるレントゲン学的FAIの存在口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 人工股関節の可動域に対する大腿骨オフセットの影響を検討した。, 国内会議人工股関節の可動域に対する大腿骨オフセットの影響口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, 新しい股関節評価を検討した。, 国内会議股関節評価はどう変わるのか[招待有り]シンポジウム・ワークショップパネル（指名）
- 第39回日本股関節学会, 2012年12月, 日本語, 日本股関節学会, 新潟, スクリュー固定によるカップの変化を検討, 国内会議ナビゲーションを用いたTHAセメントレスソケットのスクリュー固定前後での角度変化口頭発表（一般）
- 第39回日本股関節学会学術集会, 2012年12月, 日本語, 日本股関節学会学術集会, 新潟, CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度, 国内会議CT based fluoroscopic matching navigation system を使用したTHAの大腿骨コンポーネント設置角度口頭発表（一般）
- 第27回日本整形外科学会 基礎学術集会, 2012年10月, 日本語, 日本整形外科学会, 名古屋, PTENはメカニカルストレス存在下に軟骨基質産生を調節する。, 国内会議ヒト軟骨細胞においてPTENはtype II collagenの発現を制御するポスター発表
- 25th Annual Meeting of International Society for Technology in Arthroplasy, 2012年10月, 英語, Annual Meeting of International Society for Technology in Arthroplasy, シドニー, スクリュー固定によるカップの変化を検討, 国際会議Evaluation of acetabular component alignment change during screw fixation using navigation systemポスター発表
- 12th Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, 2012年06月, 英語, Annual Meeting of International Society for Computer Assisted Orthopaedic Surgery, ソウル, スクリュー固定によるカップの変化を検討, 国際会議Evaluation of acetabular component alignment change during screw fixation using navigation system口頭発表（一般）
- 第85回日本整形外科学会学術総会, 2012年05月, 日本語, 日本整形外科学会, 京都, Kerboull型プレートを用いた人工股関節再置換術の術後を検討した。, 国内会議Kerboull型プレートを用いた人工股関節再置換術の術後口頭発表（一般）
- 第56回日本リウマチ学会, 2012年04月, 日本語, 京都, 国内会議関節リウマチ患者の胃食道逆流症(GERD)に関する検討口頭発表（一般）
- 第56回日本リウマチ学会, 2012年04月, 日本語, 京都, 国内会議リウマチ患者における音楽療法の有用性の検討口頭発表（一般）
- Annual meeting of osteoarthritis research international, 2012年04月, 英語, Annual meeting of osteoarthritis research international, バルセロナ, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, 国際会議p21 regulates MMP-13 expression and decreased aggrecan expression via STAT3/ SDF-1 pathway.ポスター発表
- Osteoarthritis Research Society International, 2012年04月, 英語, 国際会議Clinical trial of step-up exercise therapy using DVD for patients with hip osteoarthritis.口頭発表（一般）
- 第25回日本軟骨代謝学会, 2012年03月, 日本語, 日本軟骨代謝学会, 名古屋, 国内会議軟骨細胞におけるAktのリン酸化はメカニカルストレスで生じるp53R2により制御される口頭発表（一般）
- 第26回日本軟骨代謝学会, 2012年03月, 日本語, 日本軟骨代謝学会, 名古屋, 国内会議メカニカルストレス応答性にp21cip1はMMP13の発現を調節するその他
- 第25回日本軟骨代謝学会, 2012年03月, 日本語, 日本軟骨代謝学会, 名古屋, メカニカルストレス応答性にp21cip1はMMP13の発現を調節する, 国内会議メカニカルストレス応答性にp21cip1はMMP13の発現を調節する口頭発表（一般）
- 第25回日本軟骨代謝学会, 2012年03月, 日本語, 日本軟骨代謝学会, 名古屋, 国内会議ヒト軟骨細胞においてPTENはtype II collagenの発現を調整する口頭発表（一般）
- 第42回日本人工関節学会, 2012年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議ナビゲーションを用いたTHAセメントレスソケットの角度計測の精度評価と臨床評価口頭発表（一般）
- 第42回日本人工関節学会, 2012年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議トリプルテーパーステム使用THAの術後ステム周囲骨密度と活動性との相関.口頭発表（一般）
- 第42回日本人工関節学会, 2012年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議Hybrid型人工股関節全置換術の10年以上の成績（大腿骨側セメンティング手技の影響の検討）口頭発表（一般）
- 2011 Annual Meeting of the Orthopaedic Research Society, 2012年02月, 英語, the Orthopaedic Research Society, サンフランシスコ, アメリカ, 国際会議Expression of p53R2 in chondrocytes is regulated by mechanical stress.ポスター発表
- 第38回日本臨床バイオメカニクス学会, 2011年11月, 日本語, 日本臨床バイオメカニクス学会, 神戸, 国内会議人工股関節イメージマッチングとその課題その他
- 2011 World Congress on Osteoarthritis, 2011年11月, 英語, Osteoarthritis reseand Society International, サンディエゴ, アメリカ, 国際会議Mechanical stress increased p21cip1 expression in chondrocytesポスター発表
- 2011 World Congress on Osteoarthritis, 2011年11月, 英語, Osteoarthritis reseand Society International, サンディエゴ, アメリカ, 国際会議Expression of p53R2 in chondrocytes is regulated by mechanical stressポスター発表
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議末期股関節症に対するChiari骨盤骨切り術の治療成績その他
- 第26回日本整形外科学会基礎学術集会, 2011年10月, 日本語, 日本整形外科学会, 群馬, 国内会議軟骨細胞におけるp53R2の発現はメカニカルストレスにより制御されるポスター発表
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議骨盤3次元CT画像を用いた骨盤座標系の自動決定法の検証口頭発表（一般）
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議一側偏心性寛骨臼回転骨切り術後、9ヶ月に対側同手術を施行された患者における歩容変化ポスター発表
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議ナビゲーションを用いたTHAセメントレスソケットのスクリュー固定前後での角度変化の評価口頭発表（一般）
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議RA股関節に対するSupport ringを用いた人工股関節置換術の成績その他
- 第38回日本股関節学会, 2011年10月, 日本語, 日本股関節学会, 鹿児島, 国内会議G2ステム使用THAの術後ステム周囲骨密度と活動性との相関口頭発表（一般）
- 第36回日本足の外科学会, 2011年09月, 日本語, 日本足の外科学会, 奈良, 国内会議Tibialis spastic varus foot without tarsal coalition: a report of two cases口頭発表（一般）
- 第5回日本CAOS研究会, 2011年09月, 日本語, 大阪市立大学, 大阪, 国内会議MDCT画像を用いた骨盤座標系の自動決定法口頭発表（一般）
- At the 24th Annual Meeting of International Society for Technology in Arthroplasy, 2011年09月, 英語, International Society for Technology in Arthroplasy, ブルージュ, ベルギー, 国際会議Leg length change in total hip arthroplasty with subtrochanteric femoral shortening osteotomy for Crowe type IV developmental hip dysplasia口頭発表（一般）
- 第84回日本整形外科学会学術総会, 2011年05月, 日本語, 日本整形外科学会, 横浜, 国内会議前初期股関節症に対する大腿骨転子間内反骨切り術の長期成績口頭発表（一般）
- 第84回日本整形外科学会学術総会, 2011年05月, 日本語, 日本整形外科学会, 横浜, 国内会議G2 stem 使用後THAではstem周囲の骨密度が温存される口頭発表（一般）
- 第116回中部日本整形災害外科学会, 2011年04月, 日本語, 中部日本整形災害外科学会, 高知, 国内会議人工股関節全置換術後にフォンダパリヌクスを使用した症例の検討～1.5mgと2.5mgについての前向き調査～口頭発表（一般）
- 第30回整形外科バイオマテリアル研究会, 2010年12月, 日本語, 整形外科バイオマテリアル研究会, 京都, 国内会議大腿骨頭径による人工股関節全置換術の術後成績の違い口頭発表（一般）
- 第38回日本関節病学会, 2010年11月, 日本語, 日本関節病学会, 京都, 国内会議metal on metal型人工股関節全置換術における短期成績-口頭発表（一般）
- 第37回日本股関節学会, 2010年10月, 日本語, 日本股関節学会, 福岡, 国内会議人工股関節全置換術後にフォンダパリヌクスを使用した症例の検討～1.5mgと2.5mgについての前向き調査～口頭発表（一般）
- 第37回日本股関節学会, 2010年10月, 日本語, 日本股関節学会, 福岡, 国内会議後方アプローチによるTHA術後の脱臼とその方向は予測可能か?―CT画像を用いたソケットとステムの設置角度の検討―シンポジウム・ワークショップパネル（公募）
- 第25回日本整形外科学会基礎学術集会, 2010年10月, 日本語, 日本整形外科学会, 京都, 国内会議温熱ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与口頭発表（一般）
- 第37回日本股関節学会, 2010年10月, 日本語, 日本股関節学会, 福岡, 国内会議タナ形成術を併用した大腿骨転子間内反骨切り術の長期成績口頭発表（一般）
- 第25回日本整形外科学会基礎学術集会, 2010年10月, 日本語, 日本整形外科学会, 京都, 国内会議p53R2の発現はメカニカルストレスにより制御される－OA治療への可能性ポスター発表
- 第37回日本股関節学会, 2010年10月, 日本語, 日本股関節学会, 福岡, 国内会議metal on metal型人工股関節全置換術における経時的成績-ADLとROM-ポスター発表
- 7th Combined meeting of the orthopaedic research societies, 2010年10月, 英語, 日本整形外科学会, 京都, 国際会議Involvement of p38 MAP kinase phosphorylation in chondrocyte apoptosis induced by heat stress.ポスター発表
- 第37回日本股関節学会, 2010年10月, 日本語, 日本股関節学会, 福岡, 国内会議G2 stem 使用THA後のstem周囲の骨密度変化口頭発表（一般）
- 2010 World congress on osteoarthritis, 2010年09月, 英語, 世界変形性関節症学会, ブリュッセル, ベルギー, 国際会議p53R2 in chondrocytes is up-regulated by mechanical stressポスター発表
- 2010 World congress on osteoarthritis, 2010年09月, 英語, 世界変形性関節症学会, ブリュッセル, ベルギー, 国際会議Involvement of p38 MAP kinase phosphorylation in chondrocytes apoptosis induced by heat stressポスター発表
- 第35回日本足の外科学会学術集会, 2010年06月, 日本語, 日本足の外科学会, 奈良, 国内会議足舟状骨偽関節に伴う距舟関節症の1例ポスター発表
- 第83回日本整形外科学会学術総会, 2010年05月, 日本語, 日本整形外科学会, 東京, 国内会議前初期股関節症に対する臼蓋形成術の成績口頭発表（一般）
- 第23回日本軟骨代謝学会, 2010年04月, 日本語, 日本軟骨代謝学会, 鹿児島, 国内会議温熱ストレスによる軟骨細胞アポトーシスにおけるp38のリン酸化の関与口頭発表（一般）
- 第23回日本軟骨代謝学会, 2010年04月, 日本語, 日本軟骨代謝学会, 鹿児島, 国内会議p53R2の発現はメカニカルストレスにより制御される－OA治療への可能性口頭発表（一般）
- 2010 AAOS Annual meeting., 2010年03月, 英語, AAOS Annual meeting., ニューオリンズ, アメリカ, 国際会議Long term results of intertrochanteric varus osteotomy for the dysplastic hipポスター発表
- 56th Annual Meeting of the Orthopaedic Research Society, 2010年03月, 英語, Orthopaedic Research Society, ニューオリンズ, アメリカ, 国際会議Autocrine Motility Factor Regulates the Cell Survival in Human Chondrocytesポスター発表
- 第40回日本人工関節学会, 2010年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議人工股関節全置換術時の大腿骨の引き下げ量は予測可能か?シンポジウム・ワークショップパネル（公募）
- 第40回日本人工関節学会, 2010年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議人工股関節全置換術後にフォンダパリニクス（1.5mg/2.5mg）を使用した症例の検討〜D-ダイマーを指標として〜口頭発表（一般）
- 第40回日本人工関節学会, 2010年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議metal on metal型人工股関節全置換術における短期成績-大腿骨頭径による比較-ポスター発表
- 第36回日本股関節学会, 2009年10月, 日本語, 日本股関節学会, 京都, 国内会議変形性股関節症に対する臼蓋形成術後の10年以上の成績口頭発表（一般）
- 第113回中部日本整形外科災害外科学会学術集会, 2009年10月, 日本語, 中部日本整形外科災害外科学会, 神戸, 国内会議前初期股関節症に対する内反骨切り術の長期成績口頭発表（一般）
- 第36回日本股関節学会, 2009年10月, 日本語, 日本股関節学会, 京都, 国内会議人工股関節全置換術後にフォンダパリニクスを使用した症例の検討―D-ダイマーを指標として口頭発表（一般）
- 第113回中部日本整形外科災害外科学会学術集会, 2009年10月, 日本語, 中部日本整形外科災害外科学会, 神戸, 国内会議人工股関節全置換術後にフォンダパリニクスを使用した症例の検討―D-ダイマーを指標として口頭発表（一般）
- 第22回日本軟骨代謝学会, 2009年03月, 日本語, 日本軟骨代謝学会, 名古屋, 国内会議軟骨細胞における温熱刺激によるp53 経路を介したアポトーシスポスター発表
- 第22回日本軟骨代謝学会, 2009年03月, 日本語, 日本軟骨代謝学会, 名古屋, 国内会議ヒト正常軟骨細胞におけるAMF のアポトーシス制御口頭発表（一般）
- 55th Annual Meeting of the Orthopaedic Research Society, 2009年02月, 英語, Orthopaedic Research Society, ラスベガス, アメリカ, 国際会議Overexpression of Autocrine motility factor induces the resistance against apoptosis in human chondrocytesポスター発表
- 第23回日本整形外科学会基礎学術集会, 2008年10月, 日本語, 日本整形外科学会, 京都, 国内会議長寿因子SIRT１はヒト軟骨細胞のアポトーシスを抑制する口頭発表（一般）
- 第23回日本整形外科学会基礎学術集会, 2008年10月, 日本語, 日本整形外科学会, 京都, 国内会議引っ張り刺激によるヒト軟骨細胞のアポトーシスとp53の関連口頭発表（一般）
- 第23回日本整形外科学会基礎学術集会, 2008年10月, 日本語, 日本整形外科学会, 京都, 国内会議リウマチ滑膜腺維芽細胞に対するＤｃＲ３のリガンド作用の検討口頭発表（一般）
- 第23回日本整形外科学会基礎学術集会, 2008年10月, 日本語, 日本整形外科学会, 京都, 国内会議マクロファージ系細胞におけるデコイレセプターＤｃＲ３の機能解析口頭発表（一般）
- 2008 World congress on osteoarthritis, 2008年09月, 英語, The Osteoarthritis Research Society International, ローマ, イタリア, 国際会議Autocrine motility factor induces the resistance against apoptosis in human chondrocytesポスター発表
- 第52回日本リウマチ学会総会, 2008年04月, 日本語, 日本リウマチ学会, 札幌, 国内会議関節リウマチ患者に対するインフリキシマブ時間短縮投与の試み口頭発表（一般）
- 第52回日本リウマチ学会総会, 2008年04月, 日本語, 日本リウマチ学会, 札幌, 国内会議リウマチ滑膜腺維芽細胞に対するＤｃＲ３の直接的作用の検討口頭発表（一般）
- 第52回日本リウマチ学会総会, 2008年04月, 日本語, 日本リウマチ学会, 札幌, 国内会議マクロファージ系細胞におけるデコイレセプターＤｃＲ３の機能解析口頭発表（一般）
- 第21回日本軟骨代謝学会, 2008年03月, 日本語, 日本軟骨代謝学会, 京都, 国内会議ヒト正常軟骨細胞におけるAMFの機能解析口頭発表（一般）
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, 2008年03月, 英語, The Orthopaedic Research Society, サンフランシスコ, アメリカ, 国際会議Inhibition of p53 pathway reduced apoptosis of chondrocytes by shear stress口頭発表（一般）
- 54thAnnualMeetingoftheOrthopaedicResearchSociety, 2008年03月, 英語, The Orthopaedic Research Society, サンフランシスコ, アメリカ, 国際会議DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis口頭発表（一般）
- 第38回日本人工関節学会, 2008年02月, 日本語, 日本人工関節学会, 沖縄, 国内会議RAに対するFLステムを用いたTHAの短期成績ポスター発表
- 2007WorldCongressonOsteoarthritis, 2007年12月, 英語, Osteoarthritis Research Society International, フロリダ, アメリカ, 国際会議p53 Inhibitor or ca suppress chondrocyte aportosis by shear stressポスター発表
- 2007WorldCongressonOsteoarthritis, 2007年12月, 英語, World Congress on Osteoarthritis, フロリダ, アメリカ, 国際会議p53 INHIBITOR CAN SUPPRESS CHONDROCYTE APOPTOSIS BY SHEAR STRESSポスター発表
- 第71回米国リウマチ学会, 2007年11月, 英語, 米国リウマチ学会, ボストン, 米国, 国際会議Anxiety is correlated with clinical conditions of rheumatoid arthritis and improved by anti-TNF alpha therapy.ポスター発表
- AmericanCollegeofRheumatology71stAnnualScientificMeeting, 2007年11月, 英語, American College of Rheumatology, ボストン, アメリカ, 国際会議Anxiety is correlated with clinical conditions of rheumatoid arthritis and improved by anti-TNF alpha therapy.口頭発表（一般）
- 第34回日本股関節学会, 2007年10月, 日本語, 日本股関節学会, 金沢, 国内会議前初期股関節症に対する内反骨切り術の長期成績（15年以上）シンポジウム・ワークショップパネル（公募）
- 第34回日本股関節学会, 2007年10月, 日本語, 日本股関節学会, 金沢, 国内会議高齢者に対するFLステムを用いたTHAの短期成績ポスター発表
- 第22回日本整形外科学会基礎学術集会, 2007年10月, 日本語, 日本整形外科学会, 浜松, 国内会議ヒト軟骨細胞を用いた引っ張り刺激（メカニカルストレス）によるアポトーシスとp53の関連ポスター発表
- 7thInternationalCartilageRepairSociety, 2007年09月, 英語, International Cartilage Repair Society, ワルシャワ, ポーランド, 国際会議SIRT1, longevity factor and class 3 histone deacetylase, regulates the apoptosis of human chondrocytes.ポスター発表
- 7thWorldCongressoftheInternationalCartilageRepairSociety, 2007年09月, 英語, International Cartilage Repair Society, ワルシャワ, ポーランド, 国際会議Shear stress induced apoptosis of human chondrocytes via p53 pathwayポスター発表
- 7thInternationalCartilageRepairSociety, 2007年09月, 英語, International Cartilage Repair Society, ワルシャワ, ポーランド, 国際会議Shear stress induced apoptosis of human chondrocytes via p53 pathwayポスター発表
- 7thWorldCongressoftheInternationalCartilageRepairSociety, 2007年09月, 英語, International Cartilage Repair Society, ワルシャワ, ポーランド, 国際会議Expression of Fas / FasL in the mouse chondrogenic ATDC5 cells口頭発表（一般）
- 第２回東アジアリウマチ学会議, 2007年05月, 英語, 韓国リウマチ学会, ソウル, 韓国, 国際会議The anxiety status and depressive symptoms were correlated with clinical conditions in Japanese patients with rheumatoid arthritis口頭発表（一般）
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議生物製剤導入がリウマチ患者の不安と抑鬱状態に及ぼす影響口頭発表（一般）
- 第51回日本リウマチ学会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議関節軟骨の変性を制御する因子シンポジウム・ワークショップパネル（公募）
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議関節リウマチ患者における血清中DcR3濃度の解析 健常者との比較口頭発表（一般）
- 第５1回日本リウマチ学会学術総会・学術集会, 2007年04月, 日本語, 有限責任中間法人日本リウマチ学会, 横浜, 国内会議関節リウマチ患者における血清中DcR3濃度の解析 健常者との比較口頭発表（一般）
- 第51回日本リウマチ学会学術総会・学術集会, 2007年04月, 日本語, 有限責任中間法人日本リウマチ学会, 横浜, 国内会議関節リウマチ滑膜線維芽細胞におけるDEC-205の発現口頭発表（一般）
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議レフルノミドとメソトレキサートを併用した関節リウマチ症例の検討ポスター発表
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議マクロファージ系細胞株におけるアポトーシス関連分子DcR3発現の検討口頭発表（一般）
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討口頭発表（一般）
- 第51回日本リウマチ学会学術総会・学術集会, 2007年04月, 日本語, 有限責任中間法人日本リウマチ学会, 横浜, 国内会議マクロファージ系細胞株U937におけるアポトーシス関連分子DcR3発現の検討口頭発表（一般）
- 第51回日本リウマチ学会総会、学術集会, 2007年04月, 日本語, 日本リウマチ学会, 横浜, 国内会議HACA陽性となり減弱したインフリキシマブの効果がMTX増量により回復した関節リウマチの1症例口頭発表（一般）
- 第51回日本リウマチ学会学術総会・学術集会, 2007年04月, 日本語, 有限責任中間法人日本リウマチ学会, 横浜, 国内会議Angiopoietin-1は滑膜細胞上のVLA-5(α5β1インテグリン)を介してシグナル伝達する口頭発表（一般）
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2021年04月01日 - 2024年03月31日運動器手術後患者の就労支援モデルの開発-働き続けられる社会のために-
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2021年04月01日 - 2024年03月31日KLF15発現制御による変形性関節症に対する治療への挑戦本研究では炎症、アポトーシスの制御という観点からKLF-15の発現を調節することで関節組織に与える影響を、軟骨組織特異的KLF-15ノックアウトマウスに変形性関節症モデルを作成し解析を行うことで変形性関節症におけるKLF-15の役割を調べるために、タモキシフェン誘導型の軟骨特異的Creマウス（Col2a1-CreERT2 transgenic マウス）とKLF15-floxed/floxedマウスを交配させ軟骨特異的KLF-15ノックアウトマウス (Col2-CreERT2/ KLF-15flox/flox)を作成した。4週令の軟骨特異的KLF-15ノックアウトマウスに対して5日間連続でタモキシフェン腹腔内投与を行った後に10週でsacrifice、膝関節及び肋軟骨より回収した軟骨組織でノックアウト効率をrealtime PCRで測定するとノックアウト効率は80%程度であり他の報告と同等であった。このモデルに軟骨の研究分野では頻用され我々もこれまで用いているDMM (destabilization of the medial meniscus) モデルを作成した。 2.軟骨特異的KLF-/-, KLF+/+の2群に対しDMMモデル作成後1日、1週、４週、８週 sacrificeし組織を回収し以下の項目を検証した。a. 画像的評価 マイクロCTを用いマウス膝関節における関節症性変化を画像的に評価したところ8週でWTとKO群で有意にKOでのOA変化が増強した。b. 組織学的評価 軟骨基質分解酵素 (MMP3,MMP13)、 炎症関連マーカー (IL-1beta, p-IKK), アポトーシスのマーカーであるTUNEL染色行ったところKLF-15 KO群で、変形性関節症組織において軟骨基質分解、炎症、アポトーシスを介した軟骨組織異化作用が亢進した
- 学術研究助成基金助成金／基盤研究(C), 2018年04月 - 2021年03月競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2018年04月 - 2021年03月競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2018年04月 - 2021年03月, 研究代表者競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2015年04月 - 2018年03月, 研究代表者競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2015年04月 - 2018年03月競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2015年04月 - 2018年03月競争的資金
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2009年 - 2011年DcR3を介した滑膜増殖制御による関節リウマチ治療の検討我々は、TNF受容体に属するおとり受容体であるDcR3が、単球・貪食細胞系細胞THP-1においてFas誘導性アポトーシスを抑制するとともに、細胞接着分子VLA4の発現を促すことにより、シクロヘキシミド誘導アポトーシスを抑制することを明らかにした。また、関節リウマチ(RA)患者の血清中DcR3が、健常者と比較して高値であることも明らかにした。さらに、DcR3が炎症性サイトカインによるRA滑膜線維芽細胞の増殖促進作用と細胞内MAPK活性化作用を、細胞表面のTL1Aを受容体として抑制することを明らかにした。DcR3はFasリガンドのおとり受容体として細胞死を抑制して炎症の促進に作用するだけではなく、直接作用として細胞接着促進による細胞死抑制及び炎症性サイトカインによる細胞増殖の抑制作用といった多面的な作用機序により、RAの病態に深く関与していることを明らかにして、RA治療ターゲットとしてのDcR3の重要性を解明した。
- 学術研究助成基金助成金／若手研究(B), 2011年, 研究代表者競争的資金
- 学術研究助成基金助成金／基盤研究(C), 2011年競争的資金