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川森 裕之
医学部附属病院 循環器内科
講師

研究者基本情報

■ 学位
  • 博士（医学）, 神戸大学
■ 研究分野
  • ライフサイエンス / 循環器内科学

研究活動情報

■ 論文
  • Tomoyo Hamana, Makoto Nishimori, Satoki Shibata, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Shunsuke Kakizaki, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Hiroshi Tsunamoto, Hiroya Okamoto, Kotaro Higuchi, Tatsuya Kitagawa, Masakazu Shinohara, Koji Kuroda, Masamichi Iwasaki, Amane Kozuki, Junya Shite, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake
    AIMS: Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI). METHODS AND RESULTS: Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell's C-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The C-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (C-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (C-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features. CONCLUSION: The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis. CLINICAL TRIAL REGISTRATION: The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).
    2024年11月, European heart journal. Digital health, 5(6) (6), 692 - 701, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yuto Osumi, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Daichi Fujimoto, Shunsuke Kakizaki, Koichi Nakamura, Tomoyo Hamana, Hiroyuki Fujii, Satoru Sasaki, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Tomofumi Takaya, Akihiko Ishida, Masamichi Iwasaki, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Combining morphological and physiological evaluations might improve the risk stratification of patients who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) culprit lesions. AIMS: We aimed to investigate the clinical utility of morphofunctional evaluation after PCI for identifying ACS patients with increased risk of subsequent clinical events. METHODS: We retrospectively studied 298 consecutive ACS patients who had undergone optical coherence tomography (OCT)-guided PCI. We performed OCT-based morphological analysis and quantitative flow ratio (QFR)-based physiological assessment immediately after PCI. The non-culprit segment (NCS) was defined as the most stenotic untreated segment in the culprit vessel. The primary outcome was target vessel failure (TVF), a composite of cardiac death, target vessel-related myocardial infarction, and ischaemia-driven target vessel revascularisation. RESULTS: During a median follow-up period of 990 days, 42 patients experienced TVF. Cox regression analysis revealed that the presence of thin-cap fibroatheroma (TCFA) in the NCS and a low post-PCI QFR, or the presence of TCFA in the NCS and a high ΔQFR in the NCS (QFRNCS), were independently associated with TVF. The subgroup with TCFA in the NCS and a low post-PCI QFR had a significantly higher incidence of TVF (75%) than the other subgroups, and those with TCFA in the NCS and a high ΔQFRNCS had a significantly higher incidence of TVF (86%) than the other subgroups. The integration of TCFA in NCS, post-PCI QFR, and ΔQFRNCS with traditional risk factors significantly enhanced the identification of subsequent TVF cases. CONCLUSIONS: Combining post-PCI OCT and QFR evaluation may enhance risk stratification for ACS patients after successful PCI, particularly in predicting subsequent TVF.
    2024年08月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 20(15) (15), e927-e936, 英語, 国際誌
    研究論文（学術雑誌）

  • Satoru Sasaki, Hiroyuki Kawamori, Takayoshi Toba, Ryo Takeshige, Yusuke Fukuyama, Takashi Hiromasa, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Toshiro Shinke, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Fractional flow reserve-computed tomography (FFRCT) has not been validated in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) for coronary artery disease due to theoretical difficulties in using nitroglycerin for such patients.Methods and Results: In this single-center study, we prospectively enrolled 21 patients (34 vessels) and performed pre-TAVR FFRCTwithout nitroglycerin, pre-TAVR invasive instantaneous wave-free ratio (iFR) measurements, and post-TAVR FFR measurements using a pressure wire. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of pre-TAVR FFRCT≤0.80 to predict post-TAVR invasive FFR ≤0.80 were 82%, 83%, 82%, 71%, and 90%, respectively. A receiver operating characteristic analysis demonstrated an optimal cutoff of 0.78 for pre-TAVR FFRCTto indicate post-TAVR FFR ≤0.80, with an area under the curve (AUC) of 0.84, and the counterpart cutoff of pre-TAVR iFR was 0.89 with an AUC of 0.86. CONCLUSIONS: FFRCTwithout nitroglycerin could be a useful non-invasive imaging modality for assessing the severity of coronary artery lesions in patients with severe AS.
    2024年03月, Circulation journal : official journal of the Japanese Circulation Society, 88(4) (4), 501 - 509, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Fukuishi Yuta, Hiroyuki Kawamori, Takayoshi Toba, Takashi Hiromasa, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Murray law-based quantitative flow ratio (μQFR) is a novel computational method that enables accurate estimation of fractional flow reserve (FFR) using a single angiographic projection. However, its diagnostic value in patients with severe aortic stenosis (AS) remains unclear. METHOD: We included 25 consecutive patients who underwent transcatheter aortic valve replacement (TAVR) for severe AS with intermediate or greater (30-90%) coronary artery disease (CAD). Pre- and post-TAVR μQFR, QFR, instantaneous flow reserve (iFR), and post-TAVR invasive FFR values were measured. We evaluated the diagnostic performance of pre-TAVR μQFR, QFR, and iFR using post-TAVR FFR ≤ 0.80 as a reference standard of ischemia. RESULT: Pre-TAVR μQFR was significantly correlated with post-TAVR FFR (r = 0.73, p < 0.0001). The area under the curve of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 was 0.91 (95% confidence interval [CI] 0.77-0.98), comparable to that of pre-TAVR iFR (0.86 [95% CI 0.71-0.98], p = 0.97). The accuracy, sensitivity, specificity, and positive and negative predictive values of pre-TAVR μQFR on post-TAVR FFR ≤ 0.8 were 84.2% (95% CI 68.7-93.4), 61.6% (95% CI 31.6-86.1), 96.0% (95% CI 79.6-99.9), 88.9% (95% CI 52.9-98.3), and 82.8% (95% CI 70.6-90.6), respectively. For pre-TAVR iFR, these values were 76.5% (95% CI 58.8-89.3), 90.9% (95% CI 58.7-99.8), 69.6% (95% CI 47.1-86.8), 58.8% (95% CI 42.8-73.1), and 94.1% (95% CI 70.8-99.1), respectively. CONCLUSION: μQFR could be useful for the physiological evaluation of patients with severe AS with concomitant CAD.
    2024年03月, Heart and vessels, 英語, 国内誌
    研究論文（学術雑誌）

  • Prognostic Significance of Nodular Calcification Derived from Non-contrast Coronary Computed Tomography in Percutaneous Coronary Intervention(タイトル和訳中)
    岩根 成豪, 鳥羽 敬義, 川森 裕之, 廣正 聖, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 綱本 浩志, 浪花 祥太, 坂本 優樹, 松濱 考志, 福石 悠太, 高橋 悠, 伊澤 有, 山本 裕之, 高谷 具史, 平田 健一, 大竹 寛雅
    (一社)日本循環器学会, 2024年03月, 日本循環器学会学術集会抄録集, 88回, OJ15 - 4, 英語

  • Impact of Pericoronary Adipose Tissue Attenuation on Clinical Outcome after Percutaneous Coronary Intervention with Second-Generation Drug-Eluting Stent(タイトル和訳中)
    浪花 祥太, 川森 裕之, 鳥羽 敬義, 廣正 聖, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 岩根 成豪, 坂本 優樹, 松濱 考志, 福石 悠太, 綱本 浩志, 樋口 功太郎, 岡本 裕哉, 岩崎 正道, 高谷 具史, 山田 愼一郎, 平田 健一, 大竹 寛雅
    (一社)日本循環器学会, 2024年03月, 日本循環器学会学術集会抄録集, 88回, OJ15 - 6, 英語

  • Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Perivascular inflammation contributes to the development of atherosclerosis and microcirculatory dysfunction. Pericoronary adipose tissue (PCAT) attenuation, measured by coronary computed tomography angiography, is a potential indicator of coronary inflammation. However, the relationship between PCAT attenuation, microcirculatory dysfunction, and periprocedural myocardial injury (PMI) remains unclear. METHODS AND RESULTS: Patients with chronic coronary syndrome who underwent coronary computed tomography angiography before percutaneous coronary intervention were retrospectively identified. PCAT attenuation and adverse plaque characteristics were assessed using coronary computed tomography angiography. The extent of microcirculatory dysfunction was evaluated using the angio-based index of microcirculatory resistance before and after percutaneous coronary intervention. Overall, 125 consecutive patients were included, with 50 experiencing PMI (PMI group) and 75 without PMI (non-PMI group). Multivariable analysis showed that older age, higher angio-based index of microcirculatory resistance, presence of adverse plaque characteristics, and higher lesion-based PCAT attenuation were independently associated with PMI occurrence (odds ratio [OR], 1.07 [95% CI, 1.01-1.13]; P=0.02; OR, 1.06 [95% CI, 1.00-1.12]; P=0.04; OR, 6.62 [95% CI, 2.13-20.6]; P=0.001; and OR, 2.89 [95% CI, 1.63-5.11]; P<0.001, respectively). High PCAT attenuation was correlated with microcirculatory dysfunction before and after percutaneous coronary intervention and its exacerbation during percutaneous coronary intervention. Adding lesion-based PCAT attenuation to the presence of adverse plaque characteristics improved the discriminatory and reclassification ability in predicting PMI. CONCLUSIONS: Adding PCAT attenuation at the culprit lesion level to coronary computed tomography angiography-derived adverse plaque characteristics may provide incremental benefit in identifying patients at risk of PMI. Our results highlight the importance of microcirculatory dysfunction in PMI development, particularly in the presence of lesions with high PCAT attenuation. REGISTRATION: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000057722; Unique identifier: UMIN000050662.
    2024年02月, Journal of the American Heart Association, 13(3) (3), e031209, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tetsuya Yamamoto, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Tomoyo Hamana, Yuto Osumi, Seigo Iwane, Shota Naniwa, Yuki Sakamoto, Koshi Matsuhama, Yuta Fukuishi, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Akihiko Ishida, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Drug-coated balloon (DCB) became a potential treatment option for patients with acute coronary syndrome (ACS); however, factors associated with target lesion failure (TLF) remain uncertain. METHODS: This retrospective, multicentre, observational study included consecutive ACS patients who underwent optical coherence tomography (OCT)-guided DCB treatment. Patients were divided into two groups according to the occurrence of TLF, a composite of cardiac death, target vessel-related myocardial infarction, and ischemia-driven target lesion revascularisation. RESULTS: We enrolled 127 patients in this study. During the median follow-up period of 562 (IQR: 342-1164) days, 24 patients (18.9%) experienced TLF, and 103 patients (81.1%) did not. The cumulative 3-year incidence of TLF was 22.0%. The cumulative 3-year incidence of TLF was the lowest in patients with plaque erosion (PE) (7.5%), followed by those with rupture (PR) (26.1%) and calcified nodule (CN) (43.5%). Multivariable Cox regression analysis revealed that plaque morphology was independently associated with TLF on pre-PCI (percutaneous coronary intervention) OCT, and residual thrombus burden (TB) was positively associated with TLF on post-PCI OCT. Further stratification by post-PCI TB revealed a comparable incidence of TLF in patients with PR (4.2%) to that of PE if the culprit lesion had a smaller post-PCI TB than the cut-off value (8.4%). TLF incidence was high in patients with CN, regardless of TB size on post-PCI OCT. CONCLUSIONS: Plaque morphology was strongly associated with TLF for ACS patients after DCB treatment. Residual TB post-PCI might be a key determinant for TLF, especially in patients with PR.
    2023年09月, International journal of cardiology, 387, 131149 - 131149, 英語, 国際誌
    研究論文（学術雑誌）

  • 経カテーテル大動脈弁置換術施行患者における冠動脈造影検査に基づく定量的冠血流比の有効性
    福石 悠太, 川森 裕之, 鳥羽 敬義, 佐々木 諭, 藤井 寛之, 濱名 智世, 大隅 祐人, 岩根 成豪, 山本 哲也, 浪花 祥太, 坂本 優樹, 松濱 考志, 平田 健一, 大竹 寛雅
    (一社)日本心血管インターベンション治療学会, 2023年08月, 日本心血管インターベンション治療学会抄録集, 31回, MO26 - 1, 英語

  • OFDIを用いたロータブレータの切削効果予測の検討
    濱名 智世, 大竹 寛雅, 川森 裕之, 鳥羽 敬義, 西森 誠, 佐々木 諭, 大隅 祐人, 岩根 成豪, 山本 哲也, 浪花 祥太, 坂本 優樹, 福石 悠太, 松濱 孝志, 平田 健一
    (一社)日本心血管インターベンション治療学会, 2023年08月, 日本心血管インターベンション治療学会抄録集, 31回, MP22 - 8, 英語

  • Tomoyo Hamana, Hiroyuki Kawamori, Takayoshi Toba, Makoto Nishimori, Kosuke Tanimura, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Yuto Osumi, Masayoshi Fujii, Seigo Iwane, Tetsuya Yamamoto, Shota Naniwa, Yuki Sakamoto, Yuta Fukuishi, Koshi Matsuhama, Ken-Ichi Hirata, Hiromasa Otake
    This study determined the predictive accuracy of optical frequency domain imaging (OFDI) on debulking effects of rotational atherectomy (RA) and compared the predictive accuracy of OFDI catheter-based with Rota wire-based prediction methods. This prospective, single-center, observational study included 55 consecutive patients who underwent OFDI-guided RA. On pre-RA OFDI images, a circle, identical to the Rota burr was drawn at the center of the OFDI catheter (OFDI catheter-based prediction method) or wire (wire-based prediction method). The area overlapping the vessel wall was defined as the predicted ablation area (P-area). The actual ablated area (A-area) was measured by superimposing the OFDI images before and after RA. The overlapping P-area and A-area were defined as overlapped ablation area (O-area), and the predictive accuracy was evaluated by %Correct area (O-area/P-area) and %Error area (A-area  - O-area/A-area). The median %Correct and %Error areas were 47.8% and 41.6%, respectively. Irrelevant ablation (low %Correct-/high % Error areas) and over ablation (high %Correct-/high % Error areas) were related to deep vessel injury and intimal flap outside the P-area. The predictive accuracy was better in the OFDI catheter-based prediction method than the wire-based prediction method in the cross sections where the OFDI catheter and wire came in contact. However, it was better in the latter than the former where the OFDI catheter and wire were not in contact. OFDI-based simulation of the RA effect is feasible though accuracy may be affected by the OFDI catheter and wire position. OFDI-based simulation of RA effect might reduce peri-procedural complications during RA.
    2023年07月, Cardiovascular intervention and therapeutics, 38(3) (3), 316 - 326, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Daichi Fujimoto, Masakazu Shinohara, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Satoru Sasaki, Tomoyo Hamana, Hiroyuki Fujii, Yuto Osumi, Naomi Hayasaka, Shigenobu Kishino, Jun Ogawa, Ken-ichi Hirata, Hiromasa Otake
    Elsevier BV, 2023年06月, Atherosclerosis, 375, 1 - 8
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takayoshi Toba, Tomoyo Hamana, Hiroyuki Kawamori, Sho Torii, Gaku Nakazawa, Hiromasa Otake
    2023年05月, Cardiovascular intervention and therapeutics, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tomoyo Hamana, Hiroyuki Kawamori, Seimi Satomi-Kobayashi, Yuzuru Yamamoto, Yoshihiko Ikeda, Ken-Ichi Hirata
    BACKGROUND: Although cardiac involvement is relatively common in mixed connective tissue disease (MCTD), few reports on MCTD-associated fulminant myocarditis are available. CASE SUMMARY: A 22-year-old woman diagnosed with MCTD was admitted to our institution for cold-like symptoms and chest pain. Echocardiography revealed that the left ventricular ejection fraction (LVEF) had rapidly decreased from 50 to 20%. Because endomyocardial biopsy revealed no significant lymphocytic infiltration, immunosuppressant drugs were not started initially; however, steroid pulse therapy (methylprednisolone, one1000 mg/day) was initiated due to prolonged symptoms and unimproved haemodynamics. Despite strong immunosuppressant therapy, the LVEF did not improve, and severe mitral regurgitation appeared. Three days after steroid pulse therapy initiation, she experienced a sudden cardiac arrest; thus, venoarterial extracorporeal membrane oxygenation (VA-ECMO) and intra-aortic balloon pumping (IABP) were initiated. Subsequent immunosuppressant therapy was continued with prednisolone (100 mg/day) and intravenous cyclophosphamide (1000 mg). Six days after steroid therapy initiation, the LVEF improved to 40% and then recovered to near-normal levels. After successful weaning off of VA-ECMO and IABP, she was discharged. Thereafter, a detailed histopathological examination revealed multi-focal signs of ischaemic micro-circulatory injury and diffuse HLA-DR in the vascular endothelium, suggesting an autoimmune inflammatory response. DISCUSSION: We report a rare case of fulminant myocarditis in a patient with MCTD who recovered with immunosuppressive treatment. Despite the absence of significant lymphocytic infiltration findings on histopathological examination, patients with MCTD may experience a dramatic clinical course. Although it is unclear whether myocarditis is triggered by viral infections, certain autoimmune mechanisms may lead to its development.
    2023年04月, European heart journal. Case reports, 7(4) (4), ytad174, 英語, 国際誌
    神戸大学リポジトリ（Kernel）へのリンク

  • Tomoyo Hamana, Hiroyuki Kawamori, Takayoshi Toba, Shunsuke Kakizaki, Koichi Nakamura, Daichi Fujimoto, Satoru Sasaki, Hiroyuki Fujii, Yuto Osumi, Tomoo Fujioka, Makoto Nishimori, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Ken-Ichi Hirata, Hiromasa Otake
    BACKGROUND: Evidence of prognostic factors for stent failure after drug-eluting stent implantation for calcified nodules (CNs) is limited. AIMS: We aimed to clarify the prognostic risk factors associated with stent failure among patients who underwent drug-eluting stent implantation for CN lesions using optical coherence tomography (OCT). METHODS: This retrospective, multicentre, observational study included 108 consecutive patients with CNs who underwent OCT-guided percutaneous coronary intervention (PCI). To evaluate the quality of CNs, we measured their signal intensity and analysed the degree of signal attenuation. All CN lesions were divided into dark or bright CNs according to the half width of signal attenuation, greater or lower than 332, respectively. RESULTS: During the median follow-up period of 523 days, 25 patients (23.1%) experienced target lesion revascularisation (TLR). The 5-year cumulative incidence of TLR was 32.6%. Multivariable Cox regression analysis revealed that younger age, haemodialysis, eruptive CNs, dark CNs assessed by pre-PCI OCT, disrupted fibrous tissue protrusions, and irregular protrusions assessed by post-PCI OCT were independently associated with TLR. The prevalence of in-stent CNs (IS-CNs) observed at follow-up OCT was significantly higher in the TLR group than in the non-TLR group. CONCLUSIONS: Factors such as younger age, haemodialysis, eruptive CNs, dark CNs, disrupted fibrous tissue, or irregular protrusions were independently related to TLR in patients with CNs. The high prevalence of IS-CNs might indicate that the main cause of stent failure implanted in CN lesions could be the recurrence of CN progression in the stented segment.
    2023年03月, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 英語, 国際誌
    研究論文（学術雑誌）

  • Diagnostic Accuracy of Nitroglycerin-free FFRCT-based Physiological Assessment in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement(タイトル和訳中)
    佐々木 諭, 大竹 寛雅, 川森 裕之, 鳥羽 敬義, 竹重 遼, 福山 裕介, 柿崎 俊介, 中村 公一, 藤本 大地, 藤井 寛之, 濱名 智世, 大隅 祐人, 山本 哲也, 藤岡 知夫, 岩根 成豪, 浪花 祥太, 坂本 優樹, 松濱 考志, 福石 悠太, 新家 俊郎, 平田 健一
    (一社)日本循環器学会, 2023年03月, 日本循環器学会学術集会抄録集, 87回, PJ094 - 4, 英語

  • Yusuke Fukuyama, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Yu Takahashi, Kyohei Sasabe, Keisuke Kimura, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Tomofumi Takaya, Kazunori Yasuda, Osamu Yamaguchi, Ken-ichi Hirata
    Springer Science and Business Media LLC, 2023年01月, Heart and Vessels, 38(5) (5), 634 - 644
    研究論文（学術雑誌）

  • Shunsuke Kakizaki, Hiromasa Otake, Fumiyasu Seike, Hiroyuki Kawamori, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Daichi Fujimoto, Koichi Nakamura, Hiroyuki Fujii, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Tomofumi Takaya, Osamu Yamaguchi, Ken-Ichi Hirata
    BACKGROUND: Optical coherence tomography-derived fractional flow reserve (OCT-FFR) correlates strongly with wire-based FFR; however, its clinical significance remains uncertain. OBJECTIVES: This study sought to investigate the relationship between post-percutaneous coronary intervention (PCI) OCT-FFR and long-term clinical outcomes in acute coronary syndrome (ACS). METHODS: This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent OCT-guided emergency PCI. We analyzed post-PCI OCT images and calculated OCT-FFR to identify independent factors associated with target vessel failure (TVF) after PCI. RESULTS: Among 364 enrolled patients, 54 experienced TVF during a median follow-up of 36 (IQR: 26-48) months. Vessel-level OCT-FFR was significantly lower in the TVF group than in the non-TVF group (0.87 vs 0.94; P < 0.001). In the multivariable Cox regression analysis, low vessel-level OCT-FFR (HR per 0.1 increase: 0.38; 95% CI: 0.29-0.49; P < 0.001) and thin-cap fibroatheroma in the nonculprit lesion were independently associated with TVF. The TVF rate of vessels with both low vessel-level OCT-FFR (<0.90) and thin-cap fibroatheroma in the nonculprit lesion was 8.1 times higher than that of all other vessels (69.3% vs 12.4%; HR: 8.13; 95% CI: 4.33-15.25; log-rank P < 0.001). Furthermore, adding vessel-level OCT-FFR to baseline characteristics and post-PCI OCT findings improved discriminatory and reclassification ability in identifying patients with subsequent TVF. CONCLUSIONS: Vessel-level OCT-FFR was an independent factor associated with TVF after PCI in patients with ACS. Adding the OCT-FFR measurement to post-PCI OCT findings may enable better discrimination of patients with subsequent TVF after PCI for ACS. (Relationship between Intracoronary Optical Coherence Tomography Derived Virtual Fractional Flow Reserve and cardiovascular outcome on Acute coronary syndrome; UMIN000043858).
    2022年10月, JACC. Cardiovascular interventions, 15(20) (20), 2035 - 2048, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Koichi Nakamura, Takayoshi Toba, Hiromasa Otake, Shunsuke Kakizaki, Daichi Fujimoto, Yu Takahashi, Yusuke Fukuyama, Hiroyuki Kawamori, Hidekazu Tanaka, Tomofumi Takaya, Masamichi Iwasaki, Amane Kozuki, Hiroya Kawai, Takatoshi Hayashi, Junya Shite, Ken-Ichi Hirata
    Percutaneous transluminal septal myocardial ablation (PTSMA) is a well-established interventional therapy for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM) as an alternative to surgical myectomy. Although guidelines recommend that PTSMA should be performed in institutions with extensive experience, it is not centralized to such high-volume centers in real-world clinical practice. Thus, this study aimed to assess the feasibility of PTSMA in non-high-volume centers. We retrospectively examined patients with HOCM who underwent PTSMA between August 2012 and May 2020 at four institutions that experienced fewer than 20 cases of PTSMA procedures. The primary clinical endpoint was a composite of safety (all-cause death, electrical defibrillation for ventricular tachycardia or fibrillation, cardiac tamponade, permanent pacemaker implantation, and repeated interventions) and efficacy endpoints (repeated interventions [PTSMA or surgical myectomy]). Fifty-eight consecutive patients were enrolled. During the 30-day follow-up, no major clinical adverse events were noted except three patients (5.2%) requiring permanent pacemaker implantation for complete atrioventricular block. The percentage of patients with New York Heart Association functional class 1 or 2 significantly increased from 8.6 to 100% (p < 0.001). In the Cox proportional hazard model, left ventricular outflow tract pressure gradient at rest ≥ 30 mmHg (hazard ratio [HR] 6.56; 95% confidence interval [CI] 1.44-29.90; p = 0.015) and mitral regurgitation grade ≥ 3 (HR 10.75; 95% CI 1.81-63.79; p = 0.009) at the 30-day follow-up were associated with a composite of major clinical adverse events. The current study demonstrated that 58 patients who underwent PTSMA in non-high-volume centers had favorable 30-day clinical outcomes, with a primary composite endpoint rate of 5.2%. A prospective study with a larger sample size and longer follow-up is warranted to verify the safety and efficacy of PTSMA in non-high-volume centers.
    2022年05月, Heart and vessels, 英語, 国内誌
    研究論文（学術雑誌）

  • Ryo Takeshige, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Ken-Ichi Hirata
    The initial process of atherosclerotic development has not been systematically evaluated. This study aimed to observe atherosclerotic progression from normal vessel wall (NVW) to atherosclerotic plaque and examine local factors associated with such progression using > 5-year long-term follow-up data obtained by serial optical coherence tomography (OCT). A total of 49 patients who underwent serial OCT for lesions with NVW over 5 years (average: 6.9 years) were enrolled. NVW was defined as a vessel wall with an OCT-detectable three-layer structure and intimal thickness ≤ 300 μm. Baseline and follow-up OCT images were matched, and OCT cross sections with NVW > 30° were enrolled. Cross sections were diagnosed as "progression" when the NVW in these cross sections was reduced by > 30° at > 5-year follow-up. Atherogenic progression from NVW to atherosclerotic plaque was observed in 40.8% of enrolled cross sections. The incidence of microchannels in an adjacent atherosclerotic plaque within the same cross section (6.7 vs. 3.3%; p = 0.046) and eccentric distribution of atherosclerotic plaque (25.0 vs. 12.6%; p < 0.001) at baseline was significantly higher in cross sections with progression than in those without. Cross sections with progression exhibited significantly higher NVW intimal thickness at baseline than cross sections without progression (200.1 ± 53.7 vs. 180.2 ± 59.6 μm; p < 0.001). Multivariate analysis revealed that the presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness at baseline were independently associated with progression at follow-up. The presence of microchannels in an adjacent atherosclerotic plaque, eccentric distribution of atherosclerotic plaque, and greater NVW intimal thickness were potentially associated with initial atherosclerotic development from NVW to atherosclerotic plaque.
    2022年01月, Heart and vessels, 37(1) (1), 1 - 11, 英語, 国内誌
    研究論文（学術雑誌）

  • Hiroshi Fujita, Takayoshi Toba, Keisuke Miwa, Masataka Suzuki, Yu Takahashi, Hiroyuki Toh, Yu Izawa, Hiroyuki Kawamori, Hiromasa Otake, Sei Fujiwara, Yoshiaki Watanabe, Atsushi Kono, Ken-Ichi Hirata
    BACKGROUND: The impact of the extent of aortic atheroma on patients' prognosis after transcatheter aortic valve replacement (TAVR) has not been completely evaluated. This study aimed to evaluate the prognostic value of the aortic atheroma volume (AAV) derived from computed tomography, and the effect of its differences among the segments of the aorta, in patients undergoing TAVR. METHODS: In total, 143 patients with symptomatic severe aortic stenosis who underwent pre-procedural computed tomography before TAVR procedure indication were evaluated. AAV was calculated by measuring the aortic lumen and vessel volume using every 1-mm axial image and was further divided into thoracic (TAAV) and abdominal segments (AbAAV). RESULTS: During a median follow-up of 651 days, 24 all-cause and 14 cardiac deaths occurred. In the Kaplan-Meier analysis, the high AAV group had significantly higher all-cause and cardiac mortalities than the low AAV group (p = 0.016 and 0.023, respectively). Regarding segmental AAV, all-cause and cardiac mortalities did not have significant differences between the high and low TAAV groups. Moreover, all-cause and cardiac mortalities were significantly higher in the high AbAAV group than in the low AbAAV group (p = 0.0043 and 0.023, respectively). The multivariable analysis showed that only AbAAV was an independent predictor for all-cause mortality (hazard ratio: 1.06, p = 0.046). CONCLUSION: AAV was significantly associated with the mortality after TAVR. The current study suggests the pre-procedural assessment of AAV is valuable in predicting prognosis after TAVR. However, further investigation with a larger sample size is needed to validate our findings.
    2021年12月, International journal of cardiology, 344, 60 - 65, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Masataka Suzuki, Takayoshi Toba, Yu Izawa, Hiroshi Fujita, Keisuke Miwa, Yu Takahashi, Hiroyuki Toh, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Yoshiaki Watanabe, Atsushi K Kono, Kenji Okada, Ken-Ichi Hirata
    Background Myocardial extracellular volume fraction (ECV), measured by cardiac magnetic resonance imaging, is a useful prognostic marker for patients who have undergone aortic valve replacement (AVR) for aortic stenosis. However, the prognostic significance of ECV measurements based on computed tomography (CT) is unclear. This study evaluated the association between ECV measured with dual-energy CT and clinical outcomes in patients with aortic stenosis who underwent transcatheter or surgical AVR. Methods and Results We retrospectively enrolled 95 consecutive patients (age, 84.0±5.0 years; 75% women) with severe aortic stenosis who underwent preprocedural CT for transcatheter AVR planning. ECV was measured using iodine density images obtained by delayed enhancement dual-energy CT. The primary end point was a composite outcome of all-cause death and hospitalization for heart failure after AVR. The mean ECV measured with CT was 28.1±3.8%. During a median follow-up of 2.6 years, 22 composite outcomes were observed, including 15 all-cause deaths and 11 hospitalizations for heart failure. In Kaplan-Meier analysis, the high ECV group (≥27.8% [median value]) had significantly higher rates of composite outcomes than the low ECV group (<27.8%) (log-rank test, P=0.012). ECV was the only independent predictor of adverse outcomes on multivariable Cox regression analysis (hazards ratio, 1.25; 95% CI, 1.10‒1.41; P<0.001). Conclusions Myocardial ECV measured with dual-energy CT in patients who underwent aortic valve intervention was an independent predictor of adverse outcomes after AVR.
    2021年09月, Journal of the American Heart Association, 10(18) (18), e020655, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shinsuke Nakano, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Akira Nagasawa, Ryo Takeshige, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Junya Shite, Amane Kozuki, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Background: The effect of intraindividual variability in lipid levels on the onset of acute coronary syndrome (ACS) remains uncertain. We evaluated the relationship between intraindividual variability in lipid levels and culprit lesion morphologies by optical coherence tomography (OCT). Methods and Results: Seventy-four consecutive patients with ACS whose cholesterol levels were assessed ≥3 times during outpatient visits before the onset of ACS were enrolled in the study; 222 patients without significant stenotic lesions were used as a control group. Based on OCT findings of culprit lesions, ACS patients were categorized into a plaque rupture ACS (PR-ACS) group (n=44) or a non-plaque rupture ACS (NPR-ACS) group (erosion or calcified nodule; n=30). Visit-to-visit variability in lipid levels was evaluated using the corrected variability independent of the mean (cVIM). Patients with ACS had significantly higher low-density lipoprotein cholesterol (LDL-C) levels and cVIM in LDL-C than the control group. The PR-ACS group had significantly higher mean LDL-C levels and greater cVIM in LDL-C than the control group. The PR-ACS group had a significantly higher cVIM than the NPR-ACS group, despite similar mean LDL-C levels. Multivariate analysis revealed that higher cVIM of LDL-C was an independent predictor of PR-ACS (odds ratio 1.06; P=0.018). Conclusions: In addition to the LDL-C level, greater visit-to-visit variability in LDL-C levels may be associated with the onset of ACS induced by plaque rupture.
    2021年09月, Circulation reports, 3(9) (9), 540 - 549, 英語, 国内誌
    研究論文（学術雑誌）

  • Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Shinsuke Nakano, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Background Although patients with a cancer history have a 2 to 3 times higher risk for acute coronary syndrome (ACS), the morphological characteristics of ACS culprit plaque in those patients and their relations with clinical outcomes remain unknown. Methods and Results This retrospective, multicenter, observational cohort study included consecutive patients with ACS who underwent optical coherence tomography-guided emergent percutaneous coronary intervention. Patients were categorized into those without a cancer history, those with a cancer history, and those currently receiving cancer treatment. ACS culprit lesions were classified as plaque rupture, plaque erosion, or calcified nodule using optical coherence tomography. Plaque erosion frequency was significantly higher in culprit lesions of patients with current cancer and patients with cancer history than in those of patients without cancer history (56.3% versus 61.7% versus 36.5%). Calcified nodule incidence was significantly higher in patients without cancer history than in patients with current cancer and patients without cancer history (patients with current cancer: 12.4% versus patients without cancer history: 25.5% versus patients without cancer history: 12.6%, P<0.001). Cancer history was independently associated with nonplaque rupture (plaque erosion or calcified nodule) in ACS culprit lesions (odds ratio, 4.00; P<0.001). Cancer history was independently associated with major adverse cardiovascular events (hazard ratio [HR], 1.98; P=0.002). Nonplaque rupture in ACS culprit lesions was independently associated with major adverse cardiovascular events (HR, 1.60; P=0.011). Conclusions Patients with a cancer history had significantly worse clinical outcomes after ACS than those without a cancer history. Those with a cancer history had significantly higher plaque erosion and calcified nodule incidences in the ACS culprit lesions, which might partly explain their worse clinical outcomes. Registration URL: www.umin.ac.jp/ctr/index.htm. Unique Identifier: UMIN000038442.
    2021年08月, Journal of the American Heart Association, 10(15) (15), e020243, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Ken-Ichi Hirata
    2021年06月, Cardiovascular intervention and therapeutics, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Akira Nagasawa, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Amane Kozuki, Junya Shite, Masamichi Iwasaki, Koji Kuroda, Tomofumi Takaya, Ken-Ichi Hirata
    Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the relationship among clinical characteristics, morphological plaque features, and long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention optical coherence tomography between April 2013 and July 2018 were retrospectively enrolled, and classified into the three groups based on the culprit lesion morphology. In the 436 patients enrolled, incidences of PR, erosion, and CN in ACS culprit lesions were 46.1, 39.9, and 14.0%, respectively. Plaque erosion was more frequent in men aged < 60 years and CN was more frequent in older adults in both sexes (≥ 80 years) (P < 0.001). Patients with CN had a higher incidence of hemodialysis treatment (P < 0.001) and diabetes (P = 0.003). Multivariate analysis revealed that ST elevation myocardial infarction (STEMI) (P = 0.049) and presence of thin-cap fibroatheroma (TCFA) at the culprit lesion were independently associated with PR; in younger patients (< 60 year), preserved left ventricular ejection fraction and lower incidence of TCFA were correlated with plaque erosion; and older age, non-STEMI, or unstable angina pectoris, higher serum brain natriuretic peptide levels, and lower incidence of TCFA were independently associated with CN. Multivariable analysis revealed that CN (odds ratio [OR] 1.990, P = 0.005), male sex (OR 2.012, P = 0.004), and older age (OR 1.036, P < 0.001) were independently associated with future adverse events during a median follow-up of 757 days. Different patient characteristics and morphological features were associated with the type of culprit lesion in patients with ACS.
    2021年05月, The international journal of cardiovascular imaging, 英語, 国際誌
    研究論文（学術雑誌）

  • Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Ken-Ichi Hirata
    Whether predicting the rotational atherectomy (RA) effect based on the position of optical frequency domain imaging (OFDI) is accurate remains uncertain. The aim of this study was to evaluate the predictive accuracy of OFDI in identifying RA location and area. Twenty-five patients who underwent RA with OFDI were included. On pre-RA OFDI images, a circle with the dimension of a Rota burr was drawn at the center of the OFDI catheter. The area where the circle overlapped with the vessel wall was defined as the predicted ablation area (P-area), and the actual ablated area (A-area) was measured. The predictive accuracy of OFDI was evaluated as follows: overlapped ablation area (O-area: overlapping P- and A-areas) divided by P-area = %Correct-area, and A-area - O-area divided by A-area = %Error-area. Cross-sections were separated into four categories based on the median values of %Correct- and %Error-area. Among 334 cross-sections, RA effects were confirmed in the predicted location in 87% of them. The median %Correct- and %Error-areas were 43.1% and 64.2%, respectively. Floppy wire, narrow lumen area, OFDI catheter close to the intima, and large arc of calcium were independently associated with good prediction (high %Correct-/low %Error-areas). Non-left anterior descending lesions, OFDI catheter far from the wire, and OFDI catheter and wire far from the intima were associated with irrelevant ablation (low %Correct-/ high %Error-areas). The accuracy of the OFDI-based predictions for RA effects was acceptable with regard to location, but not high with regard to area. Wire types, target vessels, and OFDI catheter and wire positions are important determinants for accurately predicting RA effect using pre-procedural OFDI.
    2021年04月, Heart and vessels, 英語, 国内誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • PCIのための心筋虚血評価-冠血流予備能の測定に迫る- 心臓CT検査およびFFRCTに対する当院の取り組みについて
    鳥羽 敬義, 大竹 寛雅, 川森 裕之, 伊澤 有, 渡邊 慶明, 河野 淳, 根宜 典行, 平田 健一
    (一社)日本循環器学会, 2021年03月, 日本循環器学会学術集会抄録集, 85回, CS3 - 4, 日本語

  • Kodai Komaki, Naofumi Yoshida, Seimi Satomi-Kobayashi, Yasunori Tsuboi, Masato Ogawa, Kumiko Wakida, Takayoshi Toba, Hiroyuki Kawamori, Hiromasa Otake, Atsushi Omura, Katsuhiro Yamanaka, Takeshi Inoue, Tomoya Yamashita, Yoshitada Sakai, Kazuhiro P. Izawa, Kenji Okada, Ken-ichi Hirata
    Assessment of frailty is important for risk stratification among the elderly with severe aortic stenosis (AS) when considering interventions such as surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). However, evidence of the impact of preoperative frailty on short-term postoperative outcomes or functional recovery is limited. This retrospective study included 234 consecutive patients with severe AS who underwent SAVR or TAVR at Kobe University Hospital between Dec 2013 and Dec 2019. Primary outcomes were postoperative complications, postoperative 6-min walking distance (6MWD), and home discharge rates. The mean age was 82 ± 6.6 years. There were 169 (SAVR: 80, TAVR: 89) and 65 (SAVR: 20, TAVR: 45) patients in the non-frail and frail groups, respectively (p = 0.02). The postoperative complication rates in the frail group were significantly higher than those in the non-frail group [30.8% (SAVR: 35.0%, TAVR: 28.9%) vs. 10.7% (SAVR: 15.0%, TAVR: 6.7%), p < 0.001]. The home discharge rate in the non-frail group was significantly higher than that in the frail group [85.2% (SAVR: 81.2%, TAVR: 88.8%) vs. 49.2% (SAVR: 55.0%, TAVR: 46.7%), p < 0.001]. The postoperative 6MWD in the non-frail group was significantly longer than that in the frail group [299.3 ± 87.8 m (SAVR: 321.9 ± 90.8 m, TAVR: 281.1 ± 81.3 m) vs. 141.9 ± 92.4 m (SAVR: 167.8 ± 92.5 m, TAVR: 131.6 ± 91.3 m), p < 0.001]. The TAVR group did not show a decrease in the 6MWD after intervention, regardless of frailty. We report for the first time that preoperative frailty was strongly associated with postoperative complications, 6MWD, and home discharge rates following both SAVR and TAVR. Preoperative frailty assessment may provide useful indications for planning better individualized therapeutic interventions and supporting comprehensive intensive care before and after interventions.
    Springer Science and Business Media LLC, 2021年02月, Heart and Vessels, 36(8) (8), 1234 - 1245, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hiroyuki Kawamori, Akihide Konishi, Toshiro Shinke, Hirokuni Akahori, Masaharu Ishihara, Hiroaki Tsujita, Hiromasa Otake, Takayoshi Toba, Shinsuke Nakano, Kosuke Tanimura, Yoshiro Tsukiyama, Isao Nanba, Yasumasa Kakei, Takahiro Yasuda, Takashi Omori, Takashi Kubo, Amane Kozuki, Junya Shite, Ken-ichi Hirata
    2021年01月, Heart and Vessels, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Naoki Matsukawa, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Ken-ichi Hirata
    BACKGROUND: The impact of antiplatelet drug effects on mid-term local arterial responses following percutaneous coronary intervention (PCI) remains uncertain. We evaluated the impact of the platelet reactivity of prasugrel on mid-term vascular healing between acute coronary syndrome (ACS) and stable coronary artery disease (CAD).Methods and Results:We conducted a prospective, 12-center study in 125 patients with ACS and 126 patients with stable CAD who underwent PCI with an everolimus-eluting stent (EES) and received dual antiplatelet therapy (DAPT) with prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed immediately after PCI and at the 9-month follow-up to assess the association of P2Y12reaction units (PRU) with the frequency of malapposed or uncovered struts and intrastent thrombi (IST). The incidence of abnormal mid-term OCT findings did not different between the ACS and CAD arms, regardless of clinical presentation, except that uncovered struts were more frequent in the ACS than CAD arm. PRU at PCI was significantly associated with the frequency of IST at follow-up, but not with uncovered and malapposed struts. PRU at PCI was the only independent predictor of IST detected at follow-up (odds ratio 1.009). CONCLUSIONS: In patients undergoing EES implantation and receiving prasugrel, achieving an adequate antiplatelet effect at the time of stent implantation may regulate thrombus formation throughout the follow-up period.
    Japanese Circulation Society, 2021年01月, Circulation Journal, 85(6) (6), 808 - 816, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takayoshi Toba, Hiromasa Otake, Gilwoo Choi, Hyun Jin Kim, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Akira Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Hiroyuki Kawamori, Shumpei Mori, Masahito Kawata, Charles A. Taylor, Ken-ichi Hirata
    Elsevier BV, 2021年01月, JACC: Cardiovascular Imaging, 14(1) (1), 315 - 317, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Masaru Kuroda, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Ken‐ichi Hirata
    AIMS/INTRODUCTION: Glucose fluctuation (GF) is a residual risk factor for coronary artery disease (CAD). We investigated whether GF influenced clinical outcomes and progression of coronary stenosis in stable CAD patients. MATERIALS AND METHODS: In this prospective study, 101 consecutive lipid-controlled stable CAD patients underwent percutaneous coronary intervention were enrolled, and GF was expressed as the mean amplitude of glycemic excursion (MAGE) obtained by continuous glucose monitoring before the procedure was evaluated. At 9 months after enrollment, culprit and non-culprit (mild-to-moderate stenosis without ischemia) lesions were serially assessed by angiography. Cardiovascular events (CVE) consisting of cardiovascular death, non-fatal myocardial infarction or ischemia-driven revascularization during 2-year follow up, rapid progression in non-culprit lesions (defined as ≥10% luminal narrowing progression in lesions with stenosis ≥50%, ≥30% luminal narrowing progression in non-culprit lesions with stenosis <50% or normal segment, or progression to total occlusion) were evaluated. RESULTS: CVE occurred in 25 patients, and MAGE was significantly higher in the CVE group (76.1 ± 24.8 mg/dL vs 59.3 ± 23.7 mg/dL; P = 0.003). Multivariate analysis showed that MAGE was an independent predictor of CVE (odds ratio 1.027, 95% confidence interval 1.008-1.047; P = 0.005). The optimal MAGE value to predict CVE was 70.7 mg/dL (area under the curve 0.687, 95% confidence interval 0.572-0.802; P = 0.005). Furthermore, MAGE was independently associated with rapid progression, and with the luminal narrowing progression in all non-culprit lesions (r = 0.400, P < 0.05). CONCLUSIONS: Daily GF might influence future CVE in lipid-controlled stable CAD patients.
    Wiley, 2020年12月, Journal of Diabetes Investigation, 12(6) (6), 1015 - 1024, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yu Takahashi, Takayoshi Toba, Hiromasa Otake, Yusuke Fukuyama, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Izawa, Hiroyuki Kawamori, Atsushi K. Kono, Sei Fujiwara, Ken-ichi Hirata
    To investigate the feasibility of pre-procedural morphological assessment of coronary artery calcification in severely calcified lesions with electrocardiography (ECG)-gated non-contrast computed tomography (CT). Severely calcified coronary arteries in patients who underwent ECG-gated non-contrast CT prior to optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) were studied retrospectively. CT and OCT data were co-registered by marking landmark structures such as side branches and reviewed side by side with cross-sectional images. The maximum calcium angle (MCA) and presence of nodular calcification (NC) were evaluated. A total of 496 cross-sections in 16 lesions were included in this analysis. The Pearson correlation coefficient between CT- and OCT-derived MCA was 0.92 (p < 0.001). Bland-Altman plots of OCT-derived MCA in relation to CT-derived MCA showed a mean bias of 4.8 degrees with 95% limits of agreement of - 69.7 to 79.4 degrees. Sensitivity, specificity, and positive and negative predictive values of CT in identifying MCA > 270 degrees were 90.3%, 79.7%, 92.1%, and 97.4%, respectively. Sensitivity, specificity, and positive and negative predictive values of CT in identifying NC were 73.3%, 97.5%, 47.8%, and 99.2%, respectively. ECG-gated non-contrast coronary CT might be helpful to obtain detailed information of severe coronary artery calcification before PCI.
    Springer Science and Business Media LLC, 2020年11月, The International Journal of Cardiovascular Imaging, 37(4) (4), 1445 - 1453, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Takayoshi Toba, Shumpei Mori, Yu Izawa, Hiroyuki Toh, Daisuke Tsuda, Shinsuke Shimoyama, Hiroyuki Kawamori, Hiromasa Otake, Hidekazu Tanaka, Sei Fujiwara, Ken‐ichi Hirata
    BACKGROUND: Configurational changes in the proximal aorta are relevant to the procedural difficulty of transcatheter aortic valve implantation (TAVI). Among several morphological changes involving the ascending aorta, elongation is characteristics of elderly patients with aortic stenosis and can compromise the success and safety of TAVI. However, the effect of ascending aortic elongation on the overall morphology of the proximal aorta has not been established. AIMS: Our primary purpose was to investigate the effect of ascending aortic elongation on structural changes in the proximal aorta in TAVI candidates. MATERIALS & METHODS: In total, 121 consecutive patients with severe aortic stenosis (mean age, 84.5 ± 5.3 years; 69% women) who had undergone preprocedural computed tomography before TAVI were enrolled. We examined the structural anatomy of the proximal aorta in detail, focusing on its elongation, dilatation, tilting, rotation, and wedging. RESULTS: The mean length of the ascending aorta was 68.0 ± 9.2 mm, and the length was significantly correlated with dilatation (R = .278, p = .002), rightward tilting (R = .437, p < .001), clockwise rotation (R = .228, p = .018), and deep wedging (R = -.366, p < .001) of the proximal aorta. Elongation of the ascending aorta was correlated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta in an elderly population with severe aortic stenosis. DISCUSSION: Appreciation of the clinical anatomy around the proximal aorta is required for clinicians involved in TAVI to estimate the procedural difficulty. CONCLUSION: Elongation of the ascending aorta was associated with dilatation, rightward tilting, clockwise rotation, and deep wedging of the proximal aorta.
    Wiley, 2020年11月, Clinical Anatomy, 33(8) (8), 1240 - 1248, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • H. Kawamori, A. Konishi, H. Otake, T. Toba, S. Nakano, K. Tanimura, Y. Tsukiyama, I. Namba, T. Omori, T. Shinke, K. Hirata
    Springer Japan, 2020年10月, Cardiovascular Intervention and Therapeutics, 35(4) (4), 385 - 391, 英語
    研究論文（学術雑誌）

  • H. Kawamori, A. Konishi, H. Otake, T. Toba, S. Nakano, K. Tanimura, Y. Tsukiyama, I. Namba, T. Omori, T. Shinke, K. Hirata
    In the original publication of the article, the author group was published without full names and one of the co-authors' name was published incorrectly. The full names of author group and correct co-authors' name are given in this Correction.
    Springer Science and Business Media LLC, 2020年10月, Cardiovascular Intervention and Therapeutics, 35(4) (4), 385 - 391, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yoichiro Sugizaki, Hiromasa Otake, Koji Kuroda, Hiroyuki Kawamori, Takayoshi Toba, Akira Nagasawa, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Ken-ichi Hirata
    BACKGROUND: In-stent neoatherosclerosis (NA) is a risk for future cardiovascular events through atherosclerotic progression in non-stented lesions. Using optical coherence tomography, this study assessed the efficacy of intensive therapy with 10 mg/day rosuvastatin plus 1,800 mg/day eicosapentaenoic acid (EPA) vs. standard 2.5 mg/day rosuvastatin therapy on native coronary plaques in patients with NA.Methods and Results:This was a subgroup analysis of the randomized LINK-IT trial, which was designed to compare changes in the lipid index in NA between intensive and standard therapy for 12 months. In all, 42 patients with native coronary plaques and NA were assessed. Compared with standard therapy, intensive therapy resulted in greater decreases in serum low-density lipoprotein cholesterol concentrations and greater increases in serum 18-hydroxyeicosapentaenoic acid concentrations, with significantly greater decreases in the lipid index and macrophage grade in both NA (-24 vs. 217 [P<0.001] and -15 vs. 24 [P<0.001], respectively) and native coronary plaques (-112 vs. 29 [P<0.001] and -17 vs. 1 [P<0.001], respectively) following intensive therapy. Although there was a greater increase in the macrophage grade in NA than in native coronary plaques in the standard therapy group, in the intensive therapy group there were comparable reductions in macrophage grade between NA and native coronary plaques. CONCLUSIONS: Compared with standard therapy, intensive therapy prevented atherosclerotic progression more effectively in native coronary plaques in patients with NA.
    Japanese Circulation Society, 2020年09月, Circulation Journal, 84(10) (10), 1826 - 1836, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kenichi Yanaka, Akihide Konishi, Toshiro Shinke, Amane Kozuki, Hiroyuki Kawamori, Yoshiro Tsukiyama, Osamu Iida, Makoto Kadotani, Takashi Omori, Ken-ichi Hirata
    Objectives: Balloon angioplasty for in-stent restenosis (ISR) in the superficial femoral artery (SFA) has a high recurrent restenosis rate; however, its mechanism has not been fully and precisely evaluated using high-resolution intravascular imaging. Thus, we aimed to evaluate the relationship between vascular features obtained by optical frequency domain imaging (OFDI) and recurrent restenosis at 6 months. Methods: This was a prospective multicenter single-arm study. OFDI was performed before and after balloon angioplasty, and vascular features were assessed. A multi-layered ISR pattern detected by OFDI was defined as several signal-poor appearances with a high-signal band adjacent to the luminal surface. The primary outcome was defined as recurrent restenosis 6 months after balloon angioplasty. Results: Given that this study was terminated early, only 18 patients completed the 6-month follow-up; of these, 8 developed restenosis. Recurrent restenosis at 6 months tended to be related to a multi-layered ISR pattern (odds ratio (OR), 6.67; 95% confidence interval (CI), 0.81-54.96; p=0.078) and the minimum lumen area (MLA) after balloon angioplasty (OR, 0.71; 95%CI, 0.48-1.04; p=0.077). Conclusion: A multi-layered ISR pattern and MLA after balloon angioplasty detected by OFDI might be risk factors for recurrent ISR in the SFA.
    The Editorial Committee of Annals of Vascular Diseases, 2020年09月, Annals of Vascular Diseases, 13(3) (3), 291 - 299, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiro Tsukiyama, Akihide Konishi, Toshiro Shinke, Amane Kozuki, Hiromasa Otake, Hiroyuki Kawamori, Kenichi Yanaka, Osamu Iida, Takayuki Ishihara, Takumi Inoue, Masamichi Iwasaki, Makoto Kadotani, Naoki Matsukawa, Keiji Noutomi, Yasumasa Kakei, Isao Nanba, Takashi Omori, Junya Shite, Ken-Ichi Hirata
    Although balloon angioplasty for femoropopliteal artery lesions has been associated with restenosis rates of up to 60% at 12 months, the mechanism of restenosis has not been fully evaluated. The aim of this study was to evaluate the relationship between the vascular features observed on optical frequency domain imaging (OFDI) before and after balloon angioplasty of femoropopliteal artery lesions, and restenosis at 6 months. This study was a prospective multicenter single arm study. OFDI was performed before and after balloon angioplasty and plaque characteristics and vascular features, along with de novo lesions, were assessed. The primary outcome was the presence or absence of restenosis 6 months after balloon angioplasty. Residual platelet reactivity was assessed according to VerifyNow platelet reactivity units (PRUs). The number of patients completing 6 months of follow-up was 47, of which 14 had developed restenosis. Maximum thickness of the dissection flap (odds ratio (OR) 2.71; 95% confidence interval [0.9-8.0]; p = 0.071) and lesion length were identified as risk factors for restenosis (OR 1.015; 95% confidence interval [0.001-0.029]; p = 0.039). The mean PRU at the time of treatment in patients with restenosis was significantly higher than in those without restenosis (286.3 ± 82.6 vs. 208.5 ± 03.6, p = 0.026). Long lesions and major dissection on OFDI after balloon angioplasty for femoropopliteal artery lesions increase restenosis at 6 months. In addition, high residual platelet reactivity at the time of EVT may also be a risk factor for restenosis.Clinical Trial Registration Number UMIN000021120.
    2020年06月, Cardiovascular intervention and therapeutics, 36(3) (3), 321 - 329, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Toshiro Shinke, Tatsuro Ishida, Ken-ichi Hirata
    Elsevier BV, 2020年06月, JACC: Cardiovascular Imaging, 13(6) (6), 1452 - 1454, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Investigation of Computed-Tomography Based Predictors of Acute Stroke Related to Transcatheter Aortic Valve Replacement: Aortic Wall Plaque Thickness Might be a Predictive Parameter of Stroke
    Masaki Miyasaka, Rahul P Sharma, Yoshio Maeno, Masataka Taguri, Sung-Han Yoon, Hiroyuki Kawamori, Norio Tada, Shigeaki Kato, Sharjeel Israr, Takahiro Nomura, Tomoki Ochiai, Yigal Abramowitz, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, John D Friedman, Daniel S Berman, Raj R Makkar
    OBJECTIVES: Little information is available on computed tomography (CT)-based predictors of stroke related to transcatheter aortic valve replacement (TAVR). The objective of this study was to determine whether anatomical features of the aortic valve and aorta visualized by CT are predictive parameters of stroke. METHODS: The study included 1270 patients who underwent preprocedural contrast-enhanced CT assessment and TAVR for severe aortic valve stenosis. Twenty-six patients (2.5%) who developed acute strokes that occurred within 48 hours after TAVR and 104 matched patients without strokes were identified, using 1:4 propensity-score matching. The degree of hypoattenuation in the aortic valve leaflets, calcium volume of the aortic valve, and plaque thickness in the aortic wall (the ascending aorta, aortic arch, and descending thoracic aorta) were assessed. RESULTS: There were no differences between the two groups in the degree of hypoattenuation in the aortic valve leaflets and calcium volume of the aortic valve. The plaque thickness of the aortic arch and descending aorta were greater in the stroke group than in the non-stroke group: aortic arch, 2.4 mm (IQR, 1.3-2.8 mm) vs 1.8 mm (IQR, 1.4-2.2 mm), respectively (P<.01); and descending aorta, 2.9 mm (IQR, 2.1-4.2 mm) vs 2.8 mm (IQR, 2.1-3.6 mm); respectively (P=.049). CONCLUSION: Aortic wall plaque thickness measured by contrast-enhanced CT might be a predictive parameter of strokes that occur within 48 hours after TAVR.
    2020年02月, J Invasive Cardiol, 32(2) (2), E18-E26, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yuichiro Nagano, Hiromasa Otake, Takayoshi Toba, Koji Kuroda, Yuto Shinkura, Natsuko Tahara, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Amane Harada, Katsuhiro Murakami, Maria Kiriyama, Toshihiko Oshita, Yasuhiro Irino, Hiroyuki Kawamori, Tatsuro Ishida, Ryuji Toh, Toshiro Shinke, Ken‐ichi Hirata
    Background We evaluated the importance of high-density lipoprotein (HDL) functionality for target-lesion revascularization in patients treated with coronary stents using a rapid cell-free assay system to evaluate the functional capacity of HDL to accept additional cholesterol (cholesterol-uptake capacity; CUC). Methods and Results From an optical coherence tomography (OCT) registry of patients treated with coronary stents, 207 patients were enrolled and their HDL was functionally evaluated by measuring the CUC. Follow-up OCT was performed (median duration, 24.5 months after stenting) to evaluate the presence of neoatherosclerosis. Clinical follow-up was performed to assess target-lesion revascularization for a median duration of 42.3 months after stent implantation. Neoatherosclerosis was identified in 37 patients (17.9%). Multivariate logistic regression analysis revealed that a decreased CUC was independently associated with neoatherosclerosis (odds ratio, 0.799; P<0.001). The CUC showed a significant inverse correlation with incidence of target-lesion revascularization (odds ratio, 0.887; P=0.003) and with lipid accumulation inside stents, suggesting that neoatherosclerosis contributes to the association between CUC and target-lesion revascularization. Conclusions Impaired HDL functionality, detected as decreased CUC, might lead to future stent failure by provoking atherogenic changes of the neointima within stents. Both quantitative and qualitative assessments of HDL might enable the improved prediction of clinical outcomes after stent implantation.
    Ovid Technologies (Wolters Kluwer Health), 2019年05月, Journal of the American Heart Association, 8(9) (9), e011975, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 症例から末期腎臓病患者の大動脈弁狭窄症の治療戦略を考察する 経カテーテル大動脈弁留置術(TAVI)を施行した末期腎臓病患者の一例
    河野 圭志, 清水 真央, 川森 裕之, 藤井 秀毅
    (一社)日本透析医学会, 2019年05月, 日本透析医学会雑誌, 52(Suppl.1) (Suppl.1), 353 - 353, 日本語

  • アルコール性心筋症が疑われた一例
    井藤 恭子, 沖 都麦, 田中 秀和, 今西 孝充, 川森 裕之, 平田 健一, 中町 祐司, 三枝 淳
    (公社)日本超音波医学会, 2019年04月, 超音波医学, 46(Suppl.) (Suppl.), S622 - S622, 日本語
    [査読有り]

  • JDS-JCSジョイントシンポ(Controversy or Debate)-"Stop DM for Stop CVD"生命予後改善のための糖尿病管理とは ブドウ糖変動が安定冠動脈疾患患者の心血管転帰に与える影響(The Impact of Glucose Fluctuation on Cardiovascular Outcome in Patients with Stable Coronary Artery Disease)
    山本 裕之, 大竹 寛雅, 新家 俊郎, 川森 裕之, 鳥羽 敬義, 永野 雄一朗, 築山 義朗, 谷仲 謙一, 長澤 智, 大西 裕之, 竹重 遼, 杉崎 陽一郎, 中野 槙介, 谷村 幸亮, 松岡 庸一郎, 福山 裕介, 高橋 悠, 廣田 勇士, 坂口 一彦, 平田 健一
    (一社)日本循環器学会, 2019年03月, 日本循環器学会学術集会抄録集, 83回, SY12 - 2, 英語

  • Otake H, Sugizaki Y, Toba T, Nagano Y, Tsukiyama Y, Yanaka KI, Yamamoto H, Nagasawa A, Onishi H, Takeshige R, Nakano S, Matsuoka Y, Tanimura K, Kawamori H, Shinke T, Hirata KI
    BACKGROUND: Although a recent clinical trial demonstrated that alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, significantly reduces the incidence of acute coronary events, the impact of alirocumab on plaque stabilization remains uncertain. The Efficacy of ALirocumab for Thin-cap fibroatheroma in patients with coronary Artery disease estImated by optical coherence tomogRaphy (ALTAIR) study will investigate the effect of alirocumab on thin-cap fibroatheroma (TCFA) in Japanese patients who underwent recent percutaneous coronary intervention (PCI). METHODS AND DESIGN: ALTAIR is a phase IV, open-label, randomized, parallel-group, single-center study involving blinded optical coherence tomography (OCT) image analysis in Japanese adults hospitalized for PCI and having suboptimal control of low-density lipoprotein cholesterol (LDL-C) levels (>70mg/dL) despite statin therapy. Patients will be randomized (1:1) to the alirocumab arm (alirocumab 75mg every 2 weeks added to rosuvastatin 10mg/day) or the standard-of-care arm (rosuvastatin 10mg/day, with initiation and/or dose adjustment of non-statin lipid-lowering to achieve an LDL-C target of <70mg/dL). OCT imaging will be conducted at baseline and at week 36 (post-treatment). The primary objective is to compare the alirocumab and standard-of-care arms regarding the change in TCFA fibrous-cap thickness after 9 months of treatment. CONCLUSION: The outcomes of ALTAIR (ClinicalTrials.gov identifier: NCT03552432) will provide insights into the effect of alirocumab on plaque vulnerability following PCI in patients with suboptimal LDL-C control despite stable statin therapy.
    2019年03月, J Cardiol, 73(3) (3), 228 - 232, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hiromasa Otake, Kosuke Tanimura, Yoichiro Sugizaki, Takayoshi Toba, Hiroyuki Kawamori, Toshiro Shinke, Ken-ichi Hirata
    Japanese Circulation Society, 2019年02月, Circulation Reports, 1(2) (2), 107 - 111, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Prognostic Impact of Permanent Pacemaker Implantation in Patients With Low Left Ventricular Ejection Fraction Following Transcatheter Aortic Valve Replacement
    Maeno Y, Abramowitz Y, Israr S, Yoon SH, Kubo S, Nomura T, Miyasaka M, KawamoriH, Kazuno Y, Takahashi N, Chakravarty T, Nakamura M, Sharma RP, Jilaihawi H, Makkar RR
    BACKGROUND: Data are limited regarding the clinical impact of permanent pacemaker implantation (PPI) in patients with low left ventricular ejection fraction (LVEF) after transcatheter aortic valve replacement (TAVR). The aim of this study was to determine the impact of new PPI in patients with baseline low LVEF at 2-year follow-up after TAVR. METHODS: A total of 659 patients undergoing TAVR between January 2013 and December 2015 were included in the study. Patients were divided into two groups according to the need for PPI after TAVR. These patients were further divided by their baseline LVEF: low LVEF (≤50%) and preserved LVEF (>50%). RESULTS: A total of 104 patients (15.8%) needed PPI following TAVR. After a median follow-up of 19.1 months (interquartile range, 11.4-24.4 months), overall and cardiovascular survival showed no significant differences between new PPI and no PPI (overall, log-rank P=.94; cardiovascular, log-rank P=.51). Nonetheless, patients requiring PPI who had low LVEF had higher cardiovascular mortality compared to patients with low LVEF who didn't need PPI (log-rank P<.001). Multivariable Cox hazard model demonstrated that patients with new PPI and low LVEF had higher 2-year cardiovascular mortality after TAVR (hazard ratio, 5.76; P<.001). CONCLUSION: New PPI following TAVR was not associated with overall survival or cardiovascular survival difference at 2 years. However, receiving a new PPI in the setting of low LVEF adversely impacts mid-term cardiovascular survival.
    2019年02月, J Invasive Cardiol, 31(2) (2), E15 - E22, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Miyasaka M, Yoon SH, Sharma RP, Maeno Y, Jaideep S, Taguri M, Kato S, Kawamori H, Nomura T, Ochiai T, Nemanpour S, Chakravarty T, Nakamura M, Wen C, Makkar R
    BACKGROUND: Patients with severe aortic stenosis (AS) and an extra-large annulus (ELA) area (>683 mm2) can rarely be treated by transcatheter aortic valve replacement (TAVR) because of the size limitation of the transcatheter heart valves. This study aimed to evaluate the feasibility of TAVR using a 29-mm SAPIEN3 (S3) valve in patients with ELA and S3-dimensions by post-procedural computed tomography (post-CT). Methods and Results: We included 261 patients undergoing TAVR using a 29-mm S3: 30 patients with ELA and 231 with non-ELA were identified. S3-dimensions were evaluated at the S3 inflow and annulus level by post-CT in 129 patients. The ELA group had a greater aortic annulus area measured by pre-procedural CT (737.3±54.7 vs. 578.4±41.9 mm2, P<0.0001), higher balloon inflation volume (36 vs. 33 mL, P<0.0001), a larger S3 area at inflow by post-CT (729.6±42.2 vs. 682.2±35.0 mm2, P<0.001), and a correlation between the inflation volume and S3 area (r=0.71, P=0.0005). No differences were observed between groups in paravalvular aortic regurgitation (PAR) ≥mild (43.3% vs. 27.6%, P=0.09), PAR ≥moderate (3.3% vs. 1.3%, P=0.39) or 1-year mortality (10.0% vs. 9.1%, P=0.87). CONCLUSIONS: TAVR using a 29-mm S3 with extra inflation of the delivery balloon can be considered as a treatment option for patients with severe AS and ELA.
    2019年02月, Circ J, 83(3) (3), 672 - 680, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Toba T, Shinke T, Otake H, Sugizaki Y, Takeshige R, Onishi H, Nagasawa A, Tsukiyama Y, Yanaka K, Nagano Y, Yamamoto H, Kawamori H, Matsuura A, Ishihara T, Matsumoto D, Igarashi N, Hayashi T, Yasaka Y, Kadotani M, Fujii T, Shite J, Okada M, Sakakibara T, Hirata KI
    The impact of dual antiplatelet therapy (DAPT) with adjusted-dose (3.75 mg/day) prasugrel for Japanese patients has not been fully investigated in terms of local arterial healing following the elective percutaneous coronary intervention (PCI). The ROUTE-01 elective study was a prospective, 12-center and single-arm registry that enrolled 123 patients who underwent elective PCI with everolimus-eluting stents (EESs) under DAPT with a combination of adjusted-dose prasugrel and aspirin. Serial optical coherence tomography (OCT) was performed at the index PCI and 9-month follow-up to assess the relationship between in-stent thorombus (IST) and residual platelet reactivity measuring platelet reactivity unit (PRU). The patients were classified as extensive, intermediate, and poor metabolizers by cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms. The prevalence of IST was 9.0% by 9-month OCT, with no difference amongst the three groups (p = 0.886). The incidences of malapposed and uncovered struts were not different among the groups. PRU was not statistically different among the groups. In multivariate logistic regression analysis, the independent predictor for IST on 9-month OCT was irregular protrusion (odds ratio = 8.952, p = 0.037) on post-PCI OCT, not CYP2C19 loss-of-function polymorphisms. An adequate anti-thrombotic effect with an acceptable incidence of IST was observed irrespective of CYP2C19 loss-of-function polymorphisms. Our data suggests that adjusted-dose prasugrel and aspirin is a feasible treatment option in Japanese patients treated with EESs in elective PCI.
    2019年01月, Heart Vessels, 34(6) (6), 936 - 947, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Early Clinical Outcomes of Transcatheter Aortic Valve Replacement in Left Ventricular Outflow Tract Calcification: New-Generation Device vs Early-Generation Device
    Nomura T, Maeno Y, Yoon SH, Abramowitz Y, Israr S, Miyasaka M, Kazuno Y, Takahashi N, Kawamori H, Nakamura M, Jilaihawi H, Makkar RR
    BACKGROUND: Transcatheter aortic valve replacement (TAVR) in cases with left ventricular outflow tract calcification (LVOT-CA) remains a challenging procedure. The aim of this study was to compare the early outcomes of patients undergoing TAVR in LVOT-CA with new-generation devices vs early-generation devices. METHODS: Between January 2014 and December 2016, a total of 433 patients with severe aortic stenosis who had a preprocedural multidetector computed tomography underwent TAVR in a LVOT-CA. After propensity matching, data from 119 patients in each group were analyzed. TAVR endpoints and adverse events were defined according to the Valve Academic Research Consortium-2. RESULTS: Compared with early-generation devices (Edwards Sapien/Sapien XT/CoreValve), new-generation devices (Sapien 3/Evolut R) had significantly lower incidence of mild-moderate paravalvular leak (PVL) (1.7% new vs 7.6% early; P=.03), tended to have lower incidence of moderate or severe PVL (5.0% new vs 11.8% early; P=.06), had no significant difference in device success (89.1% new vs 83.2% early; P=.19), and had a significantly higher early safety rate at 30 days (93.3% new vs 84.9% early; P=.04). For cardiac conduction disturbances, new-generation and early-generation devices had similarly high rates of new permanent pacemaker implantation (16.8% new vs 15.1% early; P=.72), whereas the number of patients who developed new-onset left bundle-branch block (LBBB) were significantly higher in those with new-generation devices (16.0% new vs 6.7% early; P=.03). CONCLUSION: In the setting of LVOT-CA, patients with new-generation devices compared to those with early-generation devices had acceptable clinical outcomes except for cardiac conduction disturbances, especially in new-onset LBBB.
    2018年11月, J Invasive Cardiol, 30(11) (11), 421 - 427, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yutaka Hatani, Hidekazu Tanaka, Akane Kajiura, Daisuke Tsuda, Yoichiro Matsuoka, Hiroyuki Kawamori, Fumitaka Soga, Kensuke Matsumoto, Takeshi Inoue, Yutaka Okita, Ken-Ichi Hirata
    An 86-year-old man was admitted our hospital because of sudden onset of dyspnea after blunt chest trauma. Because his oxygen saturation deteriorated from 92% in the supine position to 86% in the sitting position, platypnea-orthodeoxia syndrome was suspected. Transesophageal echocardiography showed severe tricuspid regurgitation (TR) caused by anterior papillary muscle rupture. Furthermore, right-to-left shunt with TR through a patent foramen ovale (PFO) was observed. The diagnosis was therefore platypnea-orthodeoxia syndrome with right-to-left shunt through PFO with shunting exacerbated by acute severe TR after blunt chest trauma. The patient underwent urgent tricuspid valve repair and PFO closure and has remained asymptomatic postoperatively.
    2018年08月, The Canadian journal of cardiology, 34(8) (8), 1088.e11-1088.e13, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Impact of the angiographic burden on the incidence of out-of-hospital ventricular fibrillation in patients with acute myocardial infarction.
    Sugizaki Y, Shinke T, Doi T, Igarashi N, Otake H, Kawamori H, Hirata KI
    2018年07月, Heart Vessels., 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoon SH, Maeno Y, Kawamori H, Miyasaka M, Nomura T, Ochiai T, Nemanpour S, Raschpichler M, Sharma R, Chakravarty T, Makkar R
    Bicuspid aortic valve is the most common congenital cardiac malformation. Aortic valve replacement is often required in older patients but the surgical risk is often extremely high. As Transcatheter aortic valve implantation (TAVI) is an established therapy for intermediate and high surgical risk patients with symptomatic severe aortic valve stenosis (AS). Advances in technology and knowledge have led to TAVI being used for other pathologies and populations such as bicuspid AS. Recently, the diagnosis and classification of bicuspid aortic valve based on multidetector computed tomography (MDCT) assessment has been proposed, which may have an impact of outcomes after TAVI. This review article describes the advancements in diagnosis and outcomes of bicuspid AS.
    2018年05月, INTERV CARDIOL, 13(2) (2), 62 - 65, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • KawamoriH, YoonSH, ChakravartyT, MaenoY, KashifM, IsrarS, AbramowitzY, MangatG, MiyasakaM, RamiT, KazunoY, TakahashiN, JilaihawiH, NakamuraM, ChengW, FriedmanJ, BermanD, SharmaR, MakkarRR
    Aims: We assessed the geometry of transcatheter heart valve (THV) and valve function associated with SAPIEN 3 implantation in patients with bicuspid aortic valve (BAV) stenosis. Methods and results: We included 280 consecutive patients who had a contrast computed tomography (CT) before and after transcatheter aortic valve implantation (TAVI) in our institution. Each THV was assessed by CT at five cross-sectional levels: inflow, annulus, mid, sinus, and outflow. The geometry of THV was assessed for eccentricity (1 - minimum diameter/maximum diameter) and expansion (CT derived external valve area/nominal external valve area). CT measurements and transthoracic echocardiogram data were compared between BAV and tricuspid aortic valve (TAV). Among 280 patients, 41 patients were diagnosed as BAV. Compared to TAV, BAV was associated with lower expansion at mid-level, sinus-level, and outflow-level (mid 94.1 ± 6.8% vs. 98.1 ± 7.8%; P = 0.002, sinus 95.9 ± 7.2% vs. 101.6 ± 8.5%; P < 0.001, outflow 107.6 ± 6.2% vs. 109.9 ± 6.6%; P = 0.043), and higher eccentricity at all levels [inflow 3.5% (1.9-5.3) vs. 6.0% (3.2-7.5); P < 0.001, annulus 3.1% (1.6-5.2) vs. 5.4% (3.1-7.8); P = 0.002, mid 3.0% (1.4-4.9) vs. 6.0% (3.3-10.4); P < 0.001, sinus 3.0% (1.7-5.1) vs. 7.6% (4.0-11.4); P < 0.001, and outflow 2.5% (1.3-4.3) vs. 4.9% (2.2-7.5); P < 0.001]. There were no differences in frequency of paravalvular leak ≥ moderate and mean post-procedural gradient between BAV and TAV. Conclusion: BAV patients have greater THV eccentricity at all levels and lower THV expansion at mid, sinus, and outflow levels than the TAV patients. There were no differences in parameters of valve function between BAV and TAV patients. Despite the observed geometrical differences, TAVI with SAPIEN 3 in BAV patients allows for feasible valve function.
    2018年01月, Eur Heart J Cardiovasc Imaging, 19(12) (12), 1408 - 1418, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Yoshio Maeno, Yigal Abramowitz, Sung -Han Yoon, Sharjeel Israr, Hasan Jilaihawi, Yusuke Watanabe, Rahul Sharma, Hiroyuki Kawamori, Masaki Miyasaka, Yoshio Kazuno, Nobuyuki Takahashi, Babak Hariri, Geeteshwar Mangat, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Raj R. Makkar
    2017年12月, AMERICAN JOURNAL OF CARDIOLOGY, 120(11) (11), 2017 - 2024, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yigal Abramowitz, Tarun Chakravarty, Philippe Pibarot, Yoshio Maeno, Hiroyuki Kawamori, David Anderson, Geeteshwar Mangat, Mamoo Nakamura, Wen Cheng, Raj R. Makkar
    2017年12月, EUROINTERVENTION, 13(12) (12), E1428 - E1435, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiroki Matsuzoe, Kensuke Matsumoto, Shumpei Mori, Takayoshi Toba, Hiroyuki Kawamori, Shinsuke Shimoyama, Hidekazu Tanaka, Toshiro Shinke, Ken-ichi Hirata
    2017年11月, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 34(11) (11), 1717 - 1720, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshio Maeno, Sung-Han Yoon, Yigal Abramowitz, Yusuke Watanabe, Hasan Jilaihawi, Mao-Shin Lin, Jason Chan, Rahul Sharma, Hideyuki Kawashima, Sharjeel Israr, Hiroyuki Kawamori, Masaki Miyasaka, Tanya Rami, Yoshio Kazuno, Geeteshwar Mangat, Mohammad Kashif, Tarun Chakravarty, Hsien-Li Kao, Michael Kang-yin Lee, Mamoo Nakamura, Ken Kozuma, Wen Cheng, Raj R. Makkar
    2017年10月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 244, 100 - 105, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshio Maeno, Yigal Abramowitz, Hiroyuki Kawamori, Yoshio Kazuno, Shunsuke Kubo, Nobuyuki Takahashi, Geeteshwar Mangat, Kazuaki Okuyama, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, John Friedman, Daniel Berman, Raj R. Makkar, Hasan Jilaihawi
    2017年10月, JACC-CARDIOVASCULAR IMAGING, 10(10) (10), 1139 - 1147, 英語
    [査読有り]
    研究論文（学術雑誌）

  • YoonSH, SharmaR, ChakravartyT, KawamoriH, MaenoY, MiyasakaM, NomuraT, OchiaiT, IsrarS, RamiT, NakamuraM, ChenW, MakkarRR
    BACKGROUND: The purpose of this study was to evaluate the outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis (AS). METHODS: From April 2012 and December 2016, 108 patients with bicuspid AS underwent TAVR using the Sapien XT (34 patients) and Sapien 3 (74 patients) valves. Procedural and clinical outcomes were assessed according to VARC-2 criteria and compared between the two devices. RESULTS: In the overall cohort, the majority of patients were male (71.3%) with an intermediate surgical risk and a mean Society of Thoracic Surgeons (STS) score of 5.2%. Compared to the Sapien XT group, the Sapien 3 group had a significantly lower STS score (3.3%±2.0% vs. 6.7%±3.6%; P=0.001). Compared to the Sapien XT group, the Sapien 3 group had a significantly lower rate of moderate or severe paravalvular leak (2.7% vs. 14.7%; P=0.03) and higher device success (97.3% vs. 82.4%; P=0.006). There were no significant differences between the two groups in terms of 30-day all-cause mortality, stroke, life-threatening bleeding, major vascular complication and acute kidney injury (stage 2 or 3). Cumulative all-cause mortality at 1-year follow-up was 6.9%. There were no significant differences in cumulative event rates for all-cause mortality at 1-year follow-up between the two groups (9.4% vs. 4.6%; log-rank P=0.47). By univariate analysis, major vascular complication was significantly associated with overall all-cause mortality [hazard ratios (HR): 7.57; 95% confidence interval (CI): 1.51-37.86; P=0.014]. CONCLUSIONS: TAVR using the balloon-expandable valves provided acceptable procedural and clinical outcomes in patients with bicuspid AS. The new-generation Sapien 3 valves showed improved procedural outcomes compared to the early-generation Sapien XT valves.
    2017年09月, Ann Cardiothorac Surg, 6(5) (5), 463 - 472, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Lars Sondergaard, Ole De Backer, Klaus F. Kofoed, Hasan Jilaihawi, Andreas Fuchs, Tarun Chakravarty, Mohammad Kashif, Yoshio Kazuno, Hiroyuki Kawamori, Yoshio Maeno, Gintautas Bieliauskas, Hongfei Guo, GreggW. Stone, Raj Makkar
    2017年07月, EUROPEAN HEART JOURNAL, 38(28) (28), 2201 - 2207, 英語
    [査読有り]
    研究論文（学術雑誌）

  • MaenoY, AbramowitzY, YoonSH, JilaihawiH, RaulS, IsrarS, MiyasakaM, KawamoriH, KazunoY, RamiT, TakahashiN, MangatG, KashifM, ChakravartyT, NakamuraM, ChengW, MakkarRR
    BACKGROUND: The aim of this study was to determine the influence of an elliptic annulus on acute device success rates following self-expanding (SE) transcatheter aortic valve replacement (TAVR) vs. balloon-expandable (BE) TAVR.Methods and Results:Outcomes were assessed using Valve Academic Research Consortium-2 definitions. Aortic annulus ratio (AAR) was measured as short axis diameter/long axis diameter. Mean AAR was 0.81±0.06. Patients were therefore divided into 2 groups: AAR <0.82 and AAR ≥0.82. For circular annuli (AAR ≥0.82; 363 patients), high device success rates were achieved in both valve groups (SE valve, 90.5% vs. BE valve, 95.0%, P=0.14). Conversely, for AAR <0.82 (374 patients), SE valves had lower device success rates than BE valves (82.5% vs. 95.3%, P=0.002). For elliptic annuli, SE-TAVR was an independent predictor of unsuccessful device implantation (OR, 6.34, P<0.001). Nonetheless, increased oversizing of SE valves for elliptic annuli was associated with an exponential rise in device success (threshold ≥17.5%; area under the curve, 0.83) but not for BE-TAVR. Furthermore, optimally oversized SE valves and BE valves had a similarly high device success for elliptic annuli (SE valve, 96.2% vs. BE valve, 95.3%). CONCLUSIONS: For circular annuli, similarly high device success was achieved for the 2 valve types. Conversely, for elliptic annuli, SE valves had a lower device success than BE valves. Device success following optimal oversizing of SE valves, however, was similar to that for BE valves.
    2017年06月, Circ J, 81(7) (7), 1036 - 1042, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Yigal Abramowitz, Hasan Jilaihawi, Philippe Pibarot, Tarun Chakravarty, Mohammad Kashif, Yoshio Kazuno, Yoshio Maeno, Hiroyuki Kawamori, Geeteshwar Mangat, John Friedman, Wen Cheng, Raj R. Makkar
    2017年06月, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 18(6) (6), 639 - 647, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sung-Han Yoon, Sabine Bleiziffer, Ole De Backer, Victoria Delgado, Takahide Arai, Johannes Ziegelmueller, Marco Barbanti, Rahul Sharma, Gidon Y. Perlman, Omar K. Khalique, Erik W. Holy, Smriti Saraf, Florian Deuschl, Buntaro Fujita, Philipp Ruile, Franz-Josef Neumann, Gregor Pache, Masao Takahashi, Hidehiro Kaneko, Tobias Schmidt, Yohei Ohno, Niklas Schofer, William K. F. Kong, Edgar Tay, Daisuke Sugiyama, Hiroyuki Kawamori, Yoshio Maeno, Yigal Abramowitz, Tarun Chakravarty, Mamoo Nakamura, Shingo Kuwata, Gerald Yong, Hsien-Li Kao, Michael Lee, Hyo-Soo Kim, Thomas Modine, S. Chiu Wong, Francesco Bedgoni, Luca Testa, Emmanuel Teiger, Christian Butter, Stephan M. Ensminger, Ulrich Schaefer, Danny Dvir, Philipp Blanke, Jonathon Leipsic, Fabian Nietlispach, Mohamed Abdel-Wahab, Bernard Chevalier, Corrado Tamburino, David Hildick-Smith, Brian K. Whisenant, Seung-Jung Park, Antonio Colombo, Azeem Latib, Susheel K. Kodali, Jeroen J. Bax, Lars Sondergaard, John G. Webb, Thierry Lefevre, Martin B. Leon, Raj Makkar
    2017年05月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 69(21) (21), 2579 - 2589, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hasan Jilaihawi, Federico M. Asch, Eric Manasse, Carlos E. Ruiz, Vladimir Jelnin, Mohammad Kashif, Hiroyuki Kawamori, Yoshio Maeno, Yoshio Kazuno, Nobuyuki Takahashi, Richard Olson, Joe Alkhatib, Daniel Berman, John Friedman, Norman Gellada, Tarun Chakravarty, Raj R. Makkar
    2017年04月, JACC-CARDIOVASCULAR IMAGING, 10(4) (4), 461 - 470, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Optimal sizing for SAPIEN 3 transcatheter aortic valve replacement in patients with or without left ventricular outflow tract calcification
    Yoshio Maeno, Yigal Abramowitz, Hasan Jilaihawi, Sharjeel Israr, Sunghan Yoon, Rahul P. Sharma, Yoshio Kazuno, Hiroyuki Kawamori, Masaki Miyasaka, Tanya Rami, Geeteshwar Mangat, Nobuyuki Takahashi, Kazuaki Okuyama, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Raj R. Makkar
    2017年04月, EUROINTERVENTION, 12(18) (18), E2177 - E2185, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yigal Abramowitz, Yoshio Kazuno, Tarun Chakravarty, Hiroyuki Kawamori, Yoshio Maeno, David Anderson, Zev Allison, Geeteshwar Mangat, Wen Cheng, Ambarish Gopal, Hasan Jilaihawi, Michael J. Mack, Raj R. Makkar
    2017年04月, EUROPEAN HEART JOURNAL, 38(16) (16), 1194 - +, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Transcatheter Aortic Valve Implantation With Different Valve Designs for Severe Device Landing Zone Calcification
    MaenoY, AbramowitzY, KazunoY, KawamoriH, MangatG, TakahashiN, ChakravartyT, NakamuraM, ChengW, JilaihawiH, MakkarRR
    2017年02月, Int Heart J, 58(1) (1), 56 - 62, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hasan Jilaihawi, Mao Chen, John Webb, Dominique Himbert, Carlos E. Ruiz, Josep Rodés-Cabau, Gregor Pache, Antonio Colombo, Georg Nickenig, Michael Lee, Corrado Tamburino, Horst Sievert, Yigal Abramowitz, Giuseppe Tarantini, Faisal Alqoofi, Tarun Chakravarty, Mohammad Kashif, Nobuyuki Takahashi, Yoshio Kazuno, Yoshio Maeno, Hiroyuki Kawamori, Alaide Chieffo, Philipp Blanke, Danny Dvir, Henrique Barbosa Ribeiro, Yuan Feng, Zhen-Gang Zhao, Jan-Malte Sinning, Chad Kliger, Gennaro Giustino, Basia Pajerski, Sebastiano Imme, Eberhard Grube, Jonathon Leipsic, Alec Vahanian, Iassen Michev, Vladimir Jelnin, Azeem Latib, Wen Cheng, Raj Makkar
    Elsevier BV, 2016年10月, JACC: Cardiovascular Imaging, 9(10) (10), 1145 - 1158, 英語
    研究論文（学術雑誌）

  • Sapien 3 Transcatheter Aortic Valve Implantation With Moderate or Without Predilation
    Yigal Abramowitz, Hasan Jilaihawi, Tarun Chakravarty, Yoshio Maeno, Hiroyuki Kawamori, Yoshio Kazuno, Geeteshwar Mangat, Tanya Rami, Zev Allison, David Anderson, Larry Chan, Wen Cheng, Raj R. Makkar
    2016年10月, JOURNAL OF INVASIVE CARDIOLOGY, 28(10) (10), 421 - 426, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshio Kazuno, Yoshio Maeno, Hiroyuki Kawamori, Nobuyuki Takahashi, Yigal Abramowitz, Hariri Babak, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, John Friedman, Daniel Berman, Raj R. Makkar, Hasan Jilaihawi
    2016年09月, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 17(9) (9), 1054 - 1062, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yigal Abramowitz, Yoshio Maeno, Tarun Chakravarty, Yoshio Kazuno, Nobuyuki Takahashi, Hiroyuki Kawamori, Geeteshwar Mangat, Wen Cheng, Hasan Jilaihawi, Raj R. Makkar
    Elsevier BV, 2016年08月, JACC: Cardiovascular Imaging, 9(8) (8), 964 - 972
    研究論文（学術雑誌）

  • Yigal Abramowitz, Hasan Jilaihawi, Tarun Chakravarty, Geeteshwar Mangat, Yoshio Maeno, Yoshio Kazuno, Nobuyuki Takahashi, Hiroyuki Kawamori, Wen Cheng, Raj R. Makkar
    2016年05月, AMERICAN JOURNAL OF CARDIOLOGY, 117(10) (10), 1636 - 1642, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Noritoshi Hiranuma, Toshiro Shinke, Gaku Nakazawa, Hiromasa Otake, Daisuke Matsumoto, Takeshi Ijichi, Hiroyuki Kawamori, Ryoji Nagoshi, Tsuyoshi Osue, Junya Shite, Ken-ichi Hirata
    2014年11月, CIRCULATION JOURNAL, 78(11) (11), 2665 - 2673, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    2013年09月, EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 14(9) (9), 865 - 875, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Amane Kozuki, Toshiro Shinke, Hiromasa Otake, Junya Shite, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Ryo Nishio, Ken-Ichi Hirata
    2013年08月, International Journal of Cardiology, 167(4) (4), 1591 - 1596, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Ryoji Nagoshi, Toshiro Shinke, Hiromasa Otake, Junya Shite, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Noritoshi Hiranuma, Akihide Konishi, Hiroto Kinutani, Naoki Miyoshi, Tomofumi Takaya, Shinichiro Yamada, Yoshinori Yasaka, Takatoshi Hayashi, Mitsuhiro Yokoyama, Hiroki Kato, Makoto Kadotani, Yoshio Ohnishi, Ken-ichi Hirata
    2013年, Circulation Journal, 77(3) (3), 652 - 660, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Hiromasa Otake, Junya Shite, Toshiro Shinke, Naoki Miyoshi, Amane Kozuki, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Noritoshi Hiranuma, Ryo Nishio, Hiroto Kinutani, Ken-ichi Hirata
    2012年08月, CIRCULATION JOURNAL, 76(8) (8), 1880 - 1888, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takumi Inoue, Junya Shite, Junghan Yoon, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Katoh, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken-ichi Hirata
    2011年09月, HEART, 97(17) (17), 1379 - 1384, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Keiji Kono, Hideki Fujii, Naoki Miyoshi, Hiroyuki Kawamori, Jyunya Shite, Ken-ichi Hirata, Masafumi Fukagawa
    2011年02月, THERAPEUTIC APHERESIS AND DIALYSIS, 15(1) (1), 44 - 50, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takahiro Sawada, Toshiro Shinke, Junya Shite, Tomoyuki Honjo, Yoko Haraguchi, Ryo Nishio, Masakazu Shinohara, Ryuji Toh, Tatsuro Ishida, Hiroyuki Kawamori, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Ken-ichi Hirata
    2011年01月, CIRCULATION JOURNAL, 75(1) (1), 99 - 105, 英語
    [査読有り]
    研究論文（学術雑誌）

  • The Ability of Optical Coherence Tomography to Monitor Percutaneous Coronary Intervention: Detailed Comparison with Intravascular Ultrasound
    Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Takahiro Sawada, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Ken-ichi Hirata
    2010年11月, JOURNAL OF INVASIVE CARDIOLOGY, 22(11) (11), 541 - 545, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takahiro Sawada, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata
    2010年07月, INTERNATIONAL JOURNAL OF CARDIOLOGY, 142(3) (3), 250 - 256, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Naoki Miyoshi, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Yoshino, Amane Kozuki, Ken-ichi Hirata
    2010年05月, CIRCULATION JOURNAL, 74(5) (5), 903 - 908, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Factors That Influence Measurements and Accurate Evaluation of Stent Apposition by Optical Coherence Tomography - Assessment Using a Phantom Model
    Takahiro Sawada, Junya Shite, Noriyuki Negi, Toshiro Shinke, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Masanobu Koto, Ken-ichi Hirata
    2009年10月, CIRCULATION JOURNAL, 73(10) (10), 1841 - 1847, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Whole Body Bioimpedance Monitoring for Outpatient Chronic Heart Failure Follow up
    Yusuke Tanino, Junya Shite, Oscar L. Paredes, Toshiro Shinke, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Naoki Miyoshi, Hiroki Kato, Naoki Yoshino, Ken-ichi Hirata
    2009年06月, CIRCULATION JOURNAL, 73(6) (6), 1074 - 1079, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Delayed Neointimalization on Sirolimus-Eluting Stents-6-Month and 12-Month Follow up by Optical Coherence Tomography
    Hiroki Katoh, Junya Shite, Toshiro Shinke, Daisuke Matsumoto, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Naoki Miyoshi, Hiroyuki Kawamori, Naoki Yoshino, Ken-ichi Hirata
    2009年06月, CIRCULATION JOURNAL, 73(6) (6), 1033 - 1037, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Pioglitazone Reduces the Necrotic-Core Component in Coronary Plaque in Association With Enhanced Plasma Adiponectin in Patients With Type 2 Diabetes Mellitus
    Daisuke Ogasawara, Junya Shite, Toshiro Shinke, Satoshi Watanabe, Hirornasa Otake, Ylislike Tanino, Takahiro Sawada, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Ken-ichi Hirata
    2009年02月, CIRCULATION JOURNAL, 73(2) (2), 343 - 351, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Takahiro Sawada, Junya Shite, Toshiro Shinke, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Ken-Ichi Hirata
    2008年12月, JOURNAL OF CARDIOLOGY, 52(3) (3), 290 - 295, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Takahiro Sawada, Junya Shite, Hector M. Garcia-Garcia, Toshiro Shinke, Satoshi Watanabe, Hiromasa Otake, Daisuke Matsumoto, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Mitsuhiro Yokoyama, Patrick W. Serruys, Ken-ichi Hirata
    2008年05月, EUROPEAN HEART JOURNAL, 29(9) (9), 1136 - 1146, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Hideo Iwahashi, Hiroyuki Kawamori, Kazuaki Fukushima
    Elsevier BV, 1999年04月, Chemico-Biological Interactions, 118(3) (3), 201 - 215
    研究論文（学術雑誌）

■ MISC
  • BT短絡術後遠隔期の血栓性閉塞に対して経皮的ステント留置術が有効であった一例
    上村航也, 福田旭伸, 大竹寛雅, 大隅祐人, 西原悠, 藤井寛之, 鳥羽敬義, 川森裕之, 城戸佐知子, 田中敏克, 近藤亜耶, 松久弘典, 高橋宏明, 岡田健次, 平田健一
    2023年, 日本成人先天性心疾患学会雑誌(Web), 12(1) (1)

  • 経カテーテル大動脈弁置換術を受けた重度大動脈弁狭窄症患者におけるニトログリセリン非使用FFRCTに基づく生理的評価の診断精度
    佐々木諭, 大竹寛雅, 川森裕之, 鳥羽敬義, 竹重遼, 福山裕介, 柿崎俊介, 中村公一, 藤本大地, 藤井寛之, 濱名智世, 大隅祐人, 山本哲也, 藤岡知夫, 岩根成豪, 浪花祥太, 坂本優樹, 松濱考志, 福石悠太, 新家俊郎, 平田健一
    2023年, 日本循環器学会学術集会(Web), 87th

  • がんの既往と第2世代ステント血栓症との関連~REAL-STレジストリ研究より~
    濱名智世, 大竹寛雅, 川森裕之, 鳥羽敬義, 廣正聖, 佐々木諭, 藤井寛之, 大隅祐人, 平田健一
    2023年, 日本腫瘍循環器学会学術集会抄録集(Web), 6th

  • 症例から末期腎臓病患者の大動脈弁狭窄症の治療戦略を考察する 経カテーテル大動脈弁留置術(TAVI)を施行した末期腎臓病患者の一例
    河野 圭志, 清水 真央, 川森 裕之, 藤井 秀毅
    (一社)日本透析医学会, 2019年05月, 日本透析医学会雑誌, 52(Suppl.1) (Suppl.1), 353 - 353, 日本語

  • The clinical impact of daily glucose fluctuation on cardiovascular events in patients with stable angina pectoris pretreated with lipid-lowering therapy
    Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Yuto Shinkura, Koji Kuroda, Yuichiro Nagano, Takayoshi Toba, Youichirou Sugizaki, Hiroyuki Onishi, Ken-ichi Hirata
    2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B331 - B331, 英語
    研究発表ペーパー・要旨（国際会議）

  • High Wall Shear Stress was Strongly Associated with Plaque Vulnerability in Computational Fluid Dynamics with Combined Optical Coherence Tomography and Heartflow FFRCT Simulation
    Takayoshi Toba, Gilwoo Choi, Yuichiro Nagano, Hiroyuki Kawamori, Toshiro Shinke, Charles Taylor, Hiromasa Otake
    2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B186 - B186, 英語
    研究発表ペーパー・要旨（国際会議）

  • The combination of rosuvastatin (10mg) and eicosapentaenoic acid (1800mg) improved native coronary plaques > 5.7 years after stent implantation
    Youichirou Sugizaki, Hiromasa Otake, Toshiro Shinke, Hiroyuki Kawamori, Koji Kuroda, Takayoshi Toba, Yuto Shinkura, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Onishi
    2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B220 - B220, 英語
    研究発表ペーパー・要旨（国際会議）

  • CT predictor of periprocedural stroke related to transcatheter aortic valve replacement.
    Masaki Miyasaka, Rahul Sharma, Sharjeel Israr, Hiroyuki Kawamori, Sunghan Yoon, Yigal Abramowitz, Tomoki Ochiai, Takahiro Nomura, Tanya Rami, Daniel Berman, Mamoo Nakamura, Wen Cheng, Raj Makkar
    2017年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18) (18), B175 - B175, 英語
    研究発表ペーパー・要旨（国際会議）

  • FEASIBILITY AND SAFETY OF SAPIEN 3 TRANSCATHETER AORTIC VALVE IMPLANTATION WITH MODERATE OR NO PREDILATATION
    Yigal Abramowitz, Hasan Jilaihawi, Tarun Chakravarty, Geeteshwar Mangat, Yoshio Maeno, Yoshio Kazuno, Nobuyuki Takahashi, Hiroyuki Kawamori, Mamoo Nakamura, Wen Cheng, Raj Makkar
    2016年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 67(13) (13), 118 - 118, 英語
    研究発表ペーパー・要旨（国際会議）

  • The Clinical Impact of Diabetes Mellitus on Outcome After Transcatheter Aortic Valve Replacement
    Yigal Abramowitz, Hasan Jilaihawi, Tarun Chakravarty, Mohammad Kashif, Yoshio Maeno, Yoshio Kazuno, Nobuyuki Takahashi, Hiroyuki Kawamori, Justin Cox, Rahul P. Sharma, Wen Cheng, Raj R. Makkar
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • Impact of Small Body Surface Area on Para-valvular Leak After Balloon-expandable Transcatheter Aortic Valve Replacement
    Yoshio Maeno, Nobuyuki Takahashi, Yigal Abramowitz, Yoshio Kazuno, Hiroyuki Kawamori, Mohammad Kashif, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Hasanian Jilaihawi, Rajendra Makkar
    2015年11月, CIRCULATION, 132, 英語
    研究発表ペーパー・要旨（国際会議）

  • Balloon-Expandable Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Mild Aortic Valve Calcification
    Yigal Abramowitz, Hasan Jilaihawi, Tarun Chakravarty, Mohammad Kashif, Yoshio Kazuno, Yoshio Maeno, Nobuyuki Takahashi, Hiroyuki Kawamori, Rahul P. Sharma, Justin Cox, Wen Cheng, Raj Makkar
    2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B257 - B257, 英語
    研究発表ペーパー・要旨（国際会議）

  • Impact of Ultra-Low Contrast Computed Tomography Compared to Three-Dimensional Transesopageal Echocardiography for Transcatheter Aortic Valve Replacement planning
    Nobuyuki Takahashi, Yoshio Kazuno, Yoshio Maeno, Mohammad Kashif, Hiroyuki Kawamori, Kazuaki Okuyama, Yigal Abramowitz, Tarun Chakravarty, Mamoo Nakamura, Wen Cheng, Raj Makkar, Hasan Jilaihawi
    2015年10月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(15) (15), B133 - B134, 英語
    研究発表ペーパー・要旨（国際会議）

  • Ryo Nishio, Satoru Kawasaki, Takeo Tanaka, Hiroyuki Kawamori, Toshimitsu Ishii, Hozuka Akita
    2015年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(10) (10), A252 - A252, 英語
    研究発表ペーパー・要旨（国際会議）

  • Natural consequence of stent malapposition tissue prolapse, thrombus and stent edge dissection assessed by optical coherence tomography
    H. Kawamori, J. Shite, T. Shinke, H. Otake, D. Matumoto, M. Nakagawa, Y. Nagoshi, A. Kozuki, H. Hariki, T. Inoue
    2011年08月, EUROPEAN HEART JOURNAL, 32, 853 - 854, 英語
    研究発表ペーパー・要旨（国際会議）

  • A NOVEL RADIOFREQUENCY SIGNAL ANALYSIS FOR CORONARY PLAQUE CHARACTERIZATION AT CULPRIT LESION USING IMAPTM: HOW CAN WE USE THE NEW PARAMETER: CONFIDENCE LEVEL?
    Amane Kozuki, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Hirotoshi Hiranuma, Ryo Nishio, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1860 - E1860, 英語
    研究発表ペーパー・要旨（国際会議）

  • NATURAL CONSEQUENCE OF STENT MALAPOSITION ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY
    Hiroyuki Kawamori, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matumoto, Masayuki Nakagawa, Yoshiharu Nagoshi, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1744 - E1744, 英語
    研究発表ペーパー・要旨（国際会議）

  • IMPACT OF CYTOCHROME P450 2C19*2 POLYMORPHISM ON THE TARGET LESION OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL.
    Ryo Nisho, Toshiro Shinke, Junya Shite, Takahiro Sawada, Ryuji Toh, Yoko Haraguchi, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1299 - E1299, 英語
    研究発表ペーパー・要旨（国際会議）

  • INFLUENCE OF PROTON PUMP INHIBITORS (PPIS) ON THE FORMATION OF INTRA-STENT THROMBUS IN JAPANESE PATIENTS RECEIVING CLOPIDOGREL WITH OR WITHOUT CYTOCHROME P450 2C19*2 POLYMORPHISM
    Ryo Nisho, Toshiro Shinke, Junya Shite, Takahiro Sawada, Ryuji Toh, Yoko Haraguchi, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Hirotoshi Hariki, Yu Taniguchi, Noritoshi Hiranuma, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1210 - E1210, 英語
    研究発表ペーパー・要旨（国際会議）

  • POTENTIAL BENEFIT OF FINAL KISSING INFLATION AFTER SINGLE STENTING TO BIFURCATION LESIONS: DIFFERENCE OF OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN SIROLIMUS AND PACLITAXEL-ELUTING STENTS
    Hirotoshi Hariki, Junya Shite, Toshiro Shinke, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Takumi Inoue, Tsuyoshi Ohsue, Yu Taniguchi, Nishio Ryo, Noritoshi Hiranuma, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1723 - E1723, 英語
    研究発表ペーパー・要旨（国際会議）

  • ASSESSMENT OF YELLOW NEOINTIMA AND MURAL THROMBI AFTER 1ST GENERATION SIROLIMUS-ELUTING STENTS USING ANGIOSCOPE AND OPTICAL COHERENCE TOMOGRAPHY
    Takumi Inoue, Toshiro Shinke, Junya Shite, Hiromasa Otake, Daisuke Matsumoto, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Amane Kozuki, Hirotoshi Hariki, Tsuyoshi Ohsue, Yu Taniguchi, Ryo Nishio, Noritoshi Hiranuma, Ken-ichi Hirata
    2011年04月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 57(14) (14), E1731 - E1731, 英語
    研究発表ペーパー・要旨（国際会議）

  • Delayed Arterial Healing After Sirolimus Eluting Stents Implantation Into the Dominant Necrotic Core Lesions in Patients With Stable Coronary Artery Disease
    Amane Kozuki, Junya Shite, Toshiro Shinke, Hiroyuki Kawamori, Masayuki Nakagawa, Ryoji Nagoshi, Hirotoshi Hariki, Takumi Inoue, Tsuyoshi Ohsue, Nagatohi Hiranuma, Ryo Nishio, Ken-ichi Hirata
    2010年11月, CIRCULATION, 122(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Difference of Optical Properties of Neointimal Tissue Between Restenosis After Drug-Eluting and Bare Metal Coronary Stent
    Toshiro Shinke, Hiroki Kato, Junya Shite, Ryoji Nagoshi, Takahiro Sawada, Hiroyuki Kawamori, Tomofumi Takaya, Takatoshi Hayashi, Shinichiro Yamada, Kenichi Hirata
    2010年11月, CIRCULATION, 122(21) (21), 英語
    研究発表ペーパー・要旨（国際会議）

  • Potential benefit of final-kissing inflation after single stenting for the treatment of bifurcation lesions: Insight from OCT observations
    H. Hariki, A. Kozuki, N. Yoshino, N. Miyoshi, H. Kato, H. Kawamori, T. Sawada, T. Shinke, J. Shite, K. Hirata
    2010年09月, EUROPEAN HEART JOURNAL, 31, 150 - 150, 英語
    研究発表ペーパー・要旨（国際会議）

  • Impact of cytochrome P450 2C19*2 polymorphism on subclinical thrombus after silorimus-eluting stent implantation in Japanese patients on dual anti-platelet therapy with clopidogrel and aspirin
    T. Sawada, J. Shite, T. Shinke, Y. Haraguchi, H. Kawamori, A. Kozuki, T. Inoue, H. Hariki, R. Nishio, K. Hirata
    2010年09月, EUROPEAN HEART JOURNAL, 31, 969 - 969, 英語
    研究発表ペーパー・要旨（国際会議）

  • Factor analysis of neointimal coverage after sirolimus-eluting stents implantation in patients with stable coronary artery disease
    A. Kozuki, J. Shite, T. Shinke, T. Sawada, H. Kawamori, H. Kato, N. Miyoshi, N. Yoshino, H. Hariki, K. Hirata
    2010年09月, EUROPEAN HEART JOURNAL, 31, 370 - 370, 英語
    研究発表ペーパー・要旨（国際会議）

  • Assessment Of Yellow Neointiam And Mural Thrombi After 1St Generation Sirolimuseluting Stents Using Angioscope And Optical Coherence Tomography
    Toshiro Shinke, Junya Shite, Hiroyuki Kawamori, Takahiro Sawada, Amane Kozuki, Hirotoshi Hariki, Takumi Inoue, Naoki Miyoshi, Ryo Nishio, Kenichi Hirata
    2010年09月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(13) (13), B58 - B58, 英語
    研究発表ペーパー・要旨（国際会議）

  • Factors that influence measurements and accurate evaluation of stent apposition by optical coherence tomography; Assessment using a phantom model
    T. Sawada, J. Shite, T. Shinke, D. Ogasawara, H. Kawamori, H. Kato, N. Miyoshi, N. Yoshino, A. Kozuki, K. Hirata
    2009年09月, EUROPEAN HEART JOURNAL, 30, 244 - 245, 英語
    研究発表ペーパー・要旨（国際会議）

  • Comparison of paclitaxel-eluting stent with sirolimus-eluting stent by optical coherence tomography: implanting two different types of drug-eluting stent in a single coronary artery
    N. Miyoshi, J. Shite, H. Ootake, T. Shinke, D. Ogasawara, T. Sawada, H. Kawamori, H. Katoh, A. Kozuki, K. Hirata
    2009年09月, EUROPEAN HEART JOURNAL, 30, 593 - 593, 英語
    研究発表ペーパー・要旨（国際会議）

  • Optical Coherence Tomography Analysis Of Target Vessel Failure After Drug Eluting And Bare Metal Coronary Stent
    Toshiro Shinke, Junya Shile, Hiroki Kato, Takahiro Sawada, Hiroyuki Kawamori, Naoki Miyoshi, Naoki Yoshino, Amane Kozuki, Hirotoshi Hariki, Ken-ichi Hirata
    2009年09月, AMERICAN JOURNAL OF CARDIOLOGY, 104(6A) (6A), 64D - 64D, 英語
    研究発表ペーパー・要旨（国際会議）

  • PCI時の造影剤腎症発症の予測因子 : 血清クレアチニン値の計測を基に
    古東 正宜, 根[ギ] 典行, 志手 淳也, 澤田 隆弘, 新家 俊郎, 川森 裕之, 吉井 勝, 上野 博之, 川光 秀昭
    2009年06月10日, Japanese journal of interventional cardiology, 24(3) (3), 262 - 265, 日本語

  • 一時的下大静脈フィルターが血栓閉塞し抜去に苦慮した先天性凝固異常合併、妊娠初期深部静脈血栓症の2例
    大村 和也, 澤田 隆弘, 吉野 直樹, 杜 隆嗣, 上月 周, 三好 直貴, 加藤 祐生, 川森 裕之, 小笠原 大介, 谷野 祐介, 新家 俊郎, 志手 淳也, 川合 宏哉, 平田 健一
    ライフサイエンス出版(株), 2009年05月, Therapeutic Research, 30(5) (5), 712 - 714, 日本語

  • PJ-819 Tissue Characterization of Optical Coherence Tomography Derived Thin Cap Fibroatehroma(PJ137,Intravascular Imagings 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Sawada Takahiro, Shite Junya, Shinke Toshiro, Imuro Yusuke, Ogasawara Daisuke, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Kozuki Amane, Hirata Kenichi
    社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 752 - 752, 英語

  • DPJ-046 Heterogeneity of Neointimal Distribution of Drug Eluting Stent Examined by Optical Coherence Tomography : Comparison with Cypher^ and Taxus^(DPJ08,Intravascular Imagings (I),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Ogasawara Daisuke, Shite Junya, Shinke Toshiro, Imuro Yusuke, Sawada Takahiro, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Kozuki Amane, Hirata Kenichi
    社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 387 - 387, 英語

  • PE-080 Coronary Plaque Progression may Associate Changes of Coronary Plaque Components with Serum Biomarker Abnormalities : Binary Intravascular Ultrasound Virtual Histology Study(PE014,Intravascular Imagings (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Kawamori Hiroyuki, Shite Junya, Shinke Toshiro, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Kozuki Amane, Hirata Kenichi
    社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 418 - 419, 英語

  • PE-325 Comparison of Paclitaxel-eluting Stents with Sirolimus-eluting Stents by Optical Coherence Tomography(PE055,Intravascular Imagings (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Miyoshi Naoki, Shite Junya, Shinke Toshiro, Tanino Yusuke, Ogasawara Daisuke, Sawada Takahiro, Kawamori Hiroyuki, Katoh Hiroki, Yoshino Naoki, Kozuki Amane, Hirata Kenichi
    社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 481 - 481, 英語

  • FRS-095 Evaluation of Bioabsorbable Polymer Coated Paclitaxel-Eluting Stent by Optical Coherence Tomography : STELLIUM First-in-Man Study(FRS20,Clinical Evidence of DES Era (2) (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Kozuki Amane, Shite Junya, Shinke Toshiro, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Kawamori Hiroyuki, Miyoshi Naoki, Katoh Hiroki, Yoshino Naoki, Conway Damian, Hirata Kenichi
    社団法人日本循環器学会, 2009年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 73, 162 - 162, 英語

  • Evaluation of Bioabsorbable Polymer Coated Paclitaxel-Eluting Stent by Optical Coherence Tomography; STELLIUM First-in-Man Study
    Amane Kozuki, Junya Shite, Toshiro Shinke, Yusuke Tanino, Daisuke Ogasawara, Takahiro Sawada, Hiroyuki Kawamori, Yuki Kato, Naoki Miyoshi, Naoki Yoshino, Damian Conway, Ken-ichi Hirata
    2009年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10) (10), A42 - A42, 英語
    研究発表ペーパー・要旨（国際会議）

  • Low Plasma Adiponectin Level and High Oxidative Stress are Associated with In Vivo Thin-Cap Fibroatheloma Prevalence in Patients with Stable Coronary Artery Disease
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Naoki Yoshino, Ken-ichi Hirata
    2008年10月, CIRCULATION, 118(18) (18), S629 - S629, 英語
    研究発表ペーパー・要旨（国際会議）

  • Difference of sirolimus-eluting stents and paclitaxel-eluting stents in cases of hybrid implantation, six-month follow-up with optical coherence tomography
    N. Miyoshi, J. Shite, Y. Tanino, D. Ogasawara, T. Sawada, H. Kawamori, H. Katoh, N. Yoshino, K. Hirata
    2008年09月, EUROPEAN HEART JOURNAL, 29, 844 - 844, 英語
    研究発表ペーパー・要旨（国際会議）

  • 好酸球増多症候群に合併した大動脈弁閉鎖不全症の1例
    小西 明英, 川合 宏哉, 多和 秀人, 川森 裕之, 大竹 寛雅, 田中 秀和, 新家 俊郎, 吉田 明弘, 平田 健一
    日本心臓病学会, 2008年05月15日, 日本心臓病学会誌 =Journal of cardiology. Japanese edition, 1(3) (3), 169 - 173, 日本語

  • 179) 部分肺静脈還流異常症の一例(第104回日本循環器学会近畿地方会)
    福田 優子, 江本 憲昭, 宮川 一也, 則定 加津子, 川森 裕之, 志手 淳也, 川合 宏哉, 吉田 明弘, 平田 健一, 田中 亜紀子, 松森 正術, 岡田 健次, 大北 裕
    社団法人日本循環器学会, 2008年04月20日, Circulation journal : official journal of the Japanese Circulation Society, 72, 1003 - 1003, 日本語

  • PJ-141 Delayed Neointimalization on Sirolimus-eluting Stents Located at a Major Side Branch Orfice Evaluation by Optical Coherence Tomography(Intravascular endoscopy/Intravascular ultrasound(05)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Katoh Hiroki, Shite Junya, Ogasawara Daisuke, Sawada Takahiro, Kawamori Hiroyuki, Miyoshi Naoki, Yoshino Naoki, Shinke Toshiro, Ohtake Hiromasa, Hirata Kenichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 546 - 546, 英語

  • 4 Drug-eluting Stent Follow-up by Optical Coherence Tomography(Progress in coronary artery imaging by OCT,Topic 1 (TP-1) (I),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Shite Junya, Miyoshi Naoki, Katoh Hiroki, Matsumoto Daisuke, Sawada Takahiro, Ogasawara Daisuke, Tanino Yusuke, Kawamori Hiroyuki, Yoshino Naoki, Hirata Ken-ichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 85 - 85, 英語

  • PE-271 Necrotic-core coronary plaque components may decrease in relation to improvement in lipid metabolism and insulin sensitivity with increase of adiponectin(Atherosclerosis, clinical(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Ogasawara Daisuke, Shite Junya, Imuro Yusuke, Sawada Takahiro, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Hirata Kenichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 428 - 428, 英語

  • PJ-117 Noninvasive Prediction of Readmission in Patients with Chronic Heart Failure, Combined Use of Plasma BNP and Bioimpedance Derived Cardiac Index(Heart failure, clinical(13)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Tanino Yusuke, Shite Junya, Paredes Oscar, Ogasawara Daisuke, Sawada Takahiro, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Hirata Kenichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 540 - 540, 英語

  • OJ-177 Clinical Features of Plaque Progression in patients with Stable Angina : Binary Intravascular Ultrasound Virtual Histology Study(Intravascular endoscopy / Intravascular ultrasound(02)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Kawamori Hiroyuki, Shite Junya, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Shinke Toshiro, Ohtake Hiromasa, Hirata Kenichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 333 - 333, 英語

  • OJ-176 Can Virtual Histology Intravascular Ultrasound Predict Thin Fibrous Cap In Vivo?(Intravascular endoscopy / Intravascular ultrasound(02)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Sawada Takahiro, Shite Junya, Shinke Toshiro, Imuro Yusuke, Ogasawara Daisuke, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Yoshino Naoki, Hirata Kenichi
    社団法人日本循環器学会, 2008年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 72, 332 - 333, 英語

  • Can we speculate thin fibrous cap only by virtual histology intravascular ultrasound in vivo?
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Ken-ichi Hirata
    2008年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 51(10) (10), A285 - A285, 英語
    研究発表ペーパー・要旨（国際会議）

  • 143)肺動脈血栓内膜摘除術が奏功した若年発症の慢性肺動脈血栓塞栓症の一例(第103回日本循環器学会近畿地方会)
    浜田 晶子, 山下 智也, 吉田 明弘, 多和 秀人, 川森 裕之, 井上 通彦, 則定 加津子, 江本 憲昭, 川合 宏哉, 志手 淳也, 平田 健一, 横山 光宏, 松森 正術, 田中 裕史, 岡田 健次, 大北 裕
    社団法人日本循環器学会, 2007年10月20日, Circulation journal : official journal of the Japanese Circulation Society, 71, 1005 - 1005, 日本語

  • Lower plasma adiponectin levels and higher oxidative stress are associated with in vivo thin-cap fibroatheroma in patients wth sable agina pctoris
    Takahiro Sawada, Junya Shite, Toshiro Shinke, Hiromasa Otake, Yusuke Tanino, Daisuke Ogasawara, Hiroyuki Kawamori, Hiroki Kato, Naoki Miyoshi, Mitsuhiro Yokoyama
    2007年03月, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 49(9) (9), 382A - 382A, 英語
    研究発表ペーパー・要旨（国際会議）

  • PE-076 Delayed Neointimalization on Sirolimus-eluting Stents Observed by Optical Coherence Tomography(Restenosis basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Katoh Hiroki, Shite Junya, Shinke Toshiro, Ohtake Hiromasa, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Kawamori Hiroyuki, Miyoshi Naoki, Oscal Paredes, Yokoyama Mitsuhiro
    社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 343 - 344, 英語

  • FRS-111 Low Plasma Adiponectin and High Oxidative Stress are Important Factors for the Presence of Thin-cap Fibroatheloma(IVUS, OCT and Angioscopy (clinical), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Sawada Takahiro, Shite Junya, Shinke Toshiro, Ohtake Hiromasa, Imuro Yusuke, Ogasawara Daisuke, Kawamori Hiroyuki, Katoh Hiroki, Miyoshi Naoki, Oscal Paredes, Yokoyama Mitsuhiro
    社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 130 - 130, 英語

  • PE-347 Determinants of Plaque Progression in Patients with Stable Angina : Serial Intravascular Ultrasound Virtual Histology Study(Intravascular endoscopy/Intravascular ultrasound-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Kawamori Hiroyuki, Shite Junya, Shinke Toshiro, Ohtake Hiromasa, Imuro Yusuke, Ogasawara Daisuke, Sawada Takahiro, Miyoshi Naoki, Katoh Hiroki, Yokoyama Mitsuhiro
    社団法人日本循環器学会, 2007年03月01日, Circulation journal : official journal of the Japanese Circulation Society, 71, 411 - 411, 英語

■ 書籍等出版物
  • 今日の治療指針 2021年度版
    分担執筆, 閉塞性動脈硬化症, 医学書院, 2021年01月

  • PCIにおけるIVUS/OCTの活かし方2018後編 / ACSにおけるIVUS/OCTの使い方
    川森裕之, 新家俊郎
    その他, メディアルファ, 2018年05月, 日本語
    その他

  • 冠動脈病変の可視化と治療
    新家俊郎,川森裕之,大竹寛雅,志手淳也
    その他, OCTにより冠動脈インターベンションをどう評価するか, メジカルビュー社, 2011年06月

■ 講演・口頭発表等
  • The Necessity to Confirm Strut Design in Front of Coronary Ostium before Coronary Angiogram in Patients with SAPIEN 3
    Hiroyuki Kawamori, Hiromasa Otake, Takayoshi Toba, Yoichiro Sugizaki, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Yu Izawa, Noriyuki Negi, Kenichi Hirata
    第84回日本循環器学会学術集会 2020年7月 日本循環器学会, 英語
    口頭発表（一般）

  • The morphological characteristics and insufficient lipid control might promote intimal thickening of saphenous vein graft after coronary artery bypass grafting
    Yuichiro Nagano, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Hachidai Takahashi, Takayoshi Toba, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Akira Nagasawa, Hiroyuki Onishi, Yoichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • The impact of glucose fluctuation on cardiovascular outcome in patients with stable coronary artery disease
    Hiroyuki Yamamoto, Hiromasa Otake, Toshiro Shinke, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Kenichi Yanaka, Akira Nagasawa, Youichiro Sugizaki, Ryo Takeshige, Hiroyuki Onishi, Kosuke Tanimura, Youichiro Matsuoka, Shinsuke Nakano, Yu Takahashi, Yusuke Fukuyama, Yushi Hirota, Kazuhiko Sakaguchi, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.
    Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Plaque progression from normal vessel wall to fibroatheroma: lessons from over 5-year follow-up optical coherence tomography study
    Ryo Takeshige, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Yoichiro Sugizaki, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • Novel Approach for In-vivo Detection of Vulnerable Plaques: Computational Fluid Dynamics in Optical Coherence Tomography and Computed Tomography Merged Model
    Takayoshi Toba, Hiromasa Otake, Gilwoo Choi, Yu Takahashi, Yusuke Fukuyama, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Ryo Takeshige, Yoichiro Sugizaki, Akira Nagasawa, Hiroyuki Ohnishi, Yoshiro Tsukiyama, Kenichi Yanaka, Hiroyuki Yamamoto, Yuichiro Nagano, Hiroyuki Kawamori, Charles Taylor, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 日本語, 日本循環器学会, 横浜, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • Clinical characteristics and morphological culprit plaque features in patients with acute coronary syndrome
    Akira Nagasawa, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Hiroyuki Onishi, Youichiro Sugizaki, Ryo Takeshige, Shinsuke Nakano, Yoichiro Matsuoka, Kosuke Tanimura, Yu Takahashi, Yusuke Fukuyama, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議
    口頭発表（一般）

  • A possible link between asymmetric expansion of SAPIEN 3 transcatheter heart valve and hypo-attenuated leaflet thickening
    Hiroyuki Kawamori, Hiromasa Otake, Takayoshi Toba, Yuichiro Nagano, Hiroyuki Yamamoto, Yoshiro Tsukiyama, Kenichi Yanaka, Yoichiro Sugizaki, Hiroyuki Onishi, Ryo Takeshige, Shinsuke Nakano, Kosuke Tanimura, Yoichiro Matsuoka, Yu Takahashi, Yusuke Fukuyama, Noriyuki Negi, Kenichi Hirata
    第83回日本循環器学会学術集会, 2019年03月, 英語, 日本循環器学会, 横浜, 国内会議
    ポスター発表

  • 下大静脈-三尖弁輪峡部通電により右冠動脈の血腫圧排，閉塞をきたした1 例 ～血管内超音波と3次元CTからの考察～
    髙見 充, 福沢公二, 木内邦彦, 森俊平, 川森裕之, 下山真介, 伊澤有, 黒瀬潤, 永松裕一, 秋田朋己, 末廣 英也, 竹本 良, 坂井淳, 矢冨敦亮, 中村俊宏, 平田健一
    カテーテルアブレーション関連秋季大会2018, 2018年11月, 日本語, 日本不整脈心電学会, 沖縄, 国内会議
    口頭発表（一般）

  • The concomitant use of statin and eicosapentaenoic acid prevented atherosclerotic progression in both in-stent neoatherosclerosis and native coronary plaques.
    Yoichiro Sugizaki, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT 2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議
    ポスター発表

  • Prediction of debulking effect of rotational atherectomy by optical frequency domain imaging
    Kosuke Tanimura, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-ichi Yanaka, Hiroyuki Yamamoto, Akira Nagawasa, Hiroyuki Onishi, Ryo Takeshige, Yoichiro Sugizaki, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議
    ポスター発表

  • Impact of dual antiplatelet therapy with low-dose prasugrel on mid-term vascular response after everolimus-eluting stent implantation in elective percutaneous coronary intervention
    Takayoshi Toba, Toshiro Shinke, Hiromasa Otake, Yoichiro Sugizaki, Ryo Takeshige, Hiroyuki Onishi, Akira Nagasawa, Yoshiro Tsukiyama, Ken-ichi Yanaka, Yuichiro Nagano, Hiroyuki Yamamoto, Hiroyuki Kawamori, Akira Matsuura, Takayuki Ishihara, Daisuke Matsumoto, Nobuaki Igarashi, Takatoshi Hayashi, Yoshinori Yasaka, Makoto Kadotani, Takashi Fujii, Junya Shite, Masaharu Okada, Takashi Sakakibara, Kenichi Hirata
    Transcatheter Cardiovascular Therapeutics (TCT 2018), 2018年09月, 英語, 心血管研究財団, サンディエゴ, 国際会議
    ポスター発表

  • 慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法
    谷仲 謙一, 中山 和彦, 谷口 悠, 大竹 寛雅, 川森 裕之, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, 田中 裕史, 大北 裕, 新家 俊郎, 江本 憲昭, 平田 健一
    第27回日本心血管インターベンション治療学会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • 慢性血栓塞栓性肺高血圧に対する肺動脈内膜血栓摘除術及びバルーン肺動脈形成術の特性を活かしたハイブリッド療法
    谷仲謙一, 中山和彦, 谷口 悠, 大竹寛雅, 川森裕之, 新倉悠人, 玉田直己, 大西裕之, 松岡庸一郎, 田中裕史, 大北裕, 新家俊郎, 江本憲昭, 平田健一
    第27回日本心血管インターベンション治療学会学術集会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • TAVR後、人口弁への血栓形成を認めた血小板低下患者の一例
    中野 槙介, 川森 裕之, 大竹 寛雅, 黒田 浩史, 新倉 悠人, 田原 奈津子, 鳥羽 敬義, 永野 雄一朗, 築山 義朗, 山本 裕之, 谷仲 謙一, 長澤 智, 大西 裕之, 竹重 遼, 杉﨑 陽一郎, 谷村 幸亮, 河野 慎吾, 松岡 庸一郎, 新家 俊郎, 平田 健一
    第27回日本心血管インターベンション治療学会, 2018年08月, 日本語, 日本心血管インターベンション治療学会, 神戸, 国内会議
    口頭発表（一般）

  • Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yoichiro Matsuoka, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Kenichi Hirata
    EUROPEAN SOCIETY OFCARDIOLOGYCONGRESS 2018(ESC 2018), 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議
    ポスター発表

  • Comparison between pulmonary endarterectomy and balloon pulmonary angioplasty focusing on RC time constant and pulmonary artery compliance in chronic thromboembolic pulmonary hypertension.
    Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Hiroyuki Kawamori, Takayoshi Toba, Yuto Shinkura, Naoki Tamada, Hiroyuki Onishi, Yoichiro Matsuoka, Hiroshi Tanaka, Yutaka Okita, Noriaki Emoto, Kenichi Hirata
    ESC Congress 2018, 2018年08月, 英語, European Society of Cardiology, ミュンヘン, 国際会議
    ポスター発表

  • CTEPHに対する治療効果及びRC timeの臨床的意義について
    谷仲 謙一, 中山 和彦, 谷口 悠, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, 川森 裕之, 大竹 寛雅, 新家 俊郎, 江本 憲昭, 平田 健一
    第3回 日本肺高血圧・肺循環学会学術集会, 2018年06月, 日本語, 日本肺高血圧・肺循環学会, 大阪, 国内会議
    口頭発表（一般）

  • CTEPH に対する治療効果の比較及びRC time の臨床的意義について
    谷仲 謙一, 中山 和彦, 谷口 悠, 新倉 悠人, 玉田 直己, 大西 裕之, 松岡 庸一郎, 川森 裕之, 大竹 寛雅, 新家俊郎, 江本 憲昭, 平田 健一
    第3回日本肺高血圧・肺循環学会学術集会, 2018年06月, 日本語, 日本肺高血圧学会日本肺循環学会共催, 大阪, 国内会議
    口頭発表（一般）

  • 慢性血栓塞栓性肺高血圧症に対するバルーン拡張術におけるpressure wireを用いた病変別急性効果の検討
    谷仲謙一, 中山和彦, 新家俊郎, 大竹寛雅, 川森裕之, 鳥羽敬義, 新倉悠人, 黒田浩史, 田原奈津子, 永野雄一朗, 築山義朗, 山本裕之, 玉田直己, 長澤智, 大西裕之, 竹重遼, 杉﨑陽一郎, 江本憲昭, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 国内会議
    口頭発表（一般）

  • 重症度の判別に苦慮した大動脈弁狭窄症の一例
    松添弘樹, 松本賢亮, 森俊平, 鳥羽敬義, 川森裕之, 下山真介, 田中秀和, 新家俊郎, 平田健一
    第124回日本循環器学会近畿地方会, 2017年11月, 日本語, 日本循環器学会, 大阪, 症例は83歳女性。以前より大動脈弁狭窄症を指摘されていたが、一年前より合計3度の心不全入院を繰り返すようになり、精査加療目的で当院紹介となった。過去の心不全入院歴は高度大動脈弁狭窄症の経過として矛盾しないものの、大動脈弁位での圧較差に比して心エコー図での大動脈弁弁口面積および大動脈弁石灰化の程度は軽度であり、重症度に不一致を認めた。心臓CTによる任意多断面再構成（MPR）画像では、各交連部下に膜様組織の増生を認め、弁口部よりも左室流出路側に最狭窄部が存在していることが判明した。患者の全身状態から経カテーテル的大動脈弁置換術を施行し、その後心不全入院は消失した。弁交連部下の膜様組織による大動脈弁狭窄の様子を、心エコー図、心臓CT-MPR法にて同定しえたため画像とともに供覧する。, 国内会議
    口頭発表（一般）

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