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原田 仁医学部附属病院 栄養管理部助教
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■ 論文- Anticancer Research USA Inc., 2024年12月, Anticancer Research, 44(12) (12), 5485 - 5493研究論文(学術雑誌)
- Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 101934 - 101934研究論文(学術雑誌)
- Elsevier BV, 2024年12月, Journal of Gastrointestinal Surgery, 28(12) (12), 2001 - 2007研究論文(学術雑誌)
- Abstract Background Esophagectomy with lymphadenectomy is the primary treatment for esophageal squamous cell carcinoma (ESCC). However, intensive dissection of lymph nodes (LNs) along the recurrent laryngeal nerve (RLN) is associated with RLN palsy and pulmonary complications leading to poor survival. Therefore, this study aimed identify the risk factors for LNs metastasis along the RLN in patients with ESCC. Methods The present study included 168 patients with lower thoracic esophageal and esophagogastric junction (EGJ) squamous cell carcinoma who underwent esophagectomy with total mediastinal lymphadenectomy at Kobe University Hospital. Left/Right cervical paraesophageal (101 L/R), left/right recurrent nerve (106 recL/R), and left tracheobronchial LNs (106 tbL) were defined as LNs along the RLN. We evaluated the pathological distance between the proximal tumor boundary and the EGJ using images of the fixed specimen (PB‐EGJ length). Results LN metastasis along the RLN was observed in 19 (11%) patients. The percentage of patients with a longer PB‐EGJ length and cLNs metastasis was higher in the LNs metastasis along the RLN positive‐group than in the RLN‐negative group (p = 0.0075 and p = 0.013, respectively). The incidence of LNs metastasis along the RLN was 0% (95% confidence interval [CI] = 0–7.7%) when the PB‐EGJ length was <4 cm. Univariate analysis showed that patients with cLNs metastasis negative had a low risk for LNs metastasis along the RLN (odds ratio = 0.26 and 95% CI = 0.083–0.82). Conclusions Patients with a PB‐EGJ length <4 cm and negative for cLNs metastasis may be candidates for the omission of lymphadenectomy along the RLN.Wiley, 2024年11月, World Journal of Surgery研究論文(学術雑誌)
- Abstract Developmental cyst is occasionally seen in children but are less common in adults. Complete removal of developmental cyst is necessary because there are risk of infection, squamous cell carcinoma, and recurrence due to incomplete resection. The best approach for resection of developmental cyst is still controversial. Although transsacral approach, open abdominal approach, or a combination of both have been often employed to date, reports of laparoscopic surgery have been appearing in recent years. We performed laparoscopic surgery for four patients with this disease: (i) 29‐year‐old woman with epidermoid cyst; (ii) 21‐year‐old woman with dermoid cyst; (iii) 55‐year‐old woman with epidermoid cyst; and (iv) 77‐year‐old woman with epidermoid cyst. No perioperative complications occurred and no recurrence has developed so far in any patients. Laparoscopic surgery can be considered as one of the optimal treatment options for developmental cyst.Wiley, 2024年11月, Asian Journal of Endoscopic Surgery, 18(1) (1)研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年09月, Surgery Today研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年09月, Esophagus, 22(1) (1), 59 - 67研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年06月, Surgery Today研究論文(学術雑誌)
- Abstract Background Herein, we report a case of gastric antrum cancer with multiple invasions to other organs that was completely cured with laparoscopic distal gastrectomy after preoperative chemotherapy in a patient with poor general condition. Case presentation An 80-year-old male patient was diagnosed with anemia during follow-up for cerebral lacunar infarction at another hospital. He was diagnosed with advanced-stage gastric antrum cancer and was referred to our hospital. On esophagogastroduodenoscopy, type 2 advanced-stage gastric cancer was detected at the greater curvature of the antrum, and the biopsy results revealed tubular adenocarcinoma. Contrast-enhanced computed tomography scan revealed multiple invasions to other organs, thick gastric wall with contrast effect, and superior mesenteric vein tumor thrombus. However, there was no evidence of distant metastasis on positron emission tomography/computed tomography scan. The clinical diagnosis was stage IVA gastric cancer. Pancreatoduodenectomy with portal vein resection could be important at this point. However, preoperative chemotherapy with S-1 and oxaliplatin was administered instead of performing extended surgery because the patient had poor general condition (performance status score of 3). The patient received three cycles of preoperative chemotherapy at the hospital along with rehabilitation and nutritional management with oral nutritional supplements. After treatment, the performance status score of the patient improved from 3 to 1. Furthermore, in terms of clinical therapeutic effect, the patient achieved partial response. Hence, laparoscopic distal gastrectomy with D2 lymph node dissection and partial transverse colectomy was performed. After surgery, the patient was admitted for oral intake on postoperative day 6 and was discharged on postoperative day 21. Based on the histopathological examination, gastric cancer had disappeared, and there were no evident malignant findings. Therefore, gastric cancer was classified as grade 3 according to the histological treatment efficacy criteria. The patient did not present with recurrence at 2 years after surgery. Conclusions By actively administering preoperative chemotherapy, minimally invasive radical surgery with maximum preservation of the surrounding organs can be performed for locally far advanced-stage gastric cancer in older patients with poor general condition.Springer Science and Business Media LLC, 2024年06月, Surgical Case Reports, 10(1) (1)研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年06月, Langenbeck's Archives of Surgery, 409(1) (1)研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年05月, Surgical Endoscopy, 38(7) (7), 3625 - 3635研究論文(学術雑誌)
- Background In Japan, preoperative adjuvant chemotherapy followed by surgical resection is the standard treatment for patients with locally advanced esophageal squamous cell carcinoma. However, the risk of recurrence after surgical resection remains high. Although a randomized controlled trial evaluating the efficacy of nivolumab, a fully human monoclonal anti-programmed death 1 antibody, as postoperative adjuvant therapy after neoadjuvant chemoradiotherapy and surgery established its superior efficacy as adjuvant therapy, the efficacy for patients who received preoperative adjuvant chemotherapy has not been demonstrated. This study aims to elucidate the efficacy and safety of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. Methods This study is a multi-institutional, single-arm, Phase II trial. We plan to recruit 130 esophageal squamous cell carcinoma patients, who have undergone preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. If the patient did not have a pathological complete response, nivolumab is started as a postoperative adjuvant therapy within 4–16 weeks after surgery. The nivolumab dose is 480 mg/day every four weeks. Nivolumab is administered for up to 12 months. The primary endpoint is disease-free survival; the secondary endpoints are overall survival, distant metastasis-free survival, and incidence of adverse events. Discussion To our knowledge this study is the first trial establishing the efficacy of nivolumab as postoperative adjuvant therapy for patients with esophageal squamous cell carcinoma after preoperative adjuvant chemotherapy with docetaxel and cisplatin plus 5-fluorouracil followed by surgical resection. In Japan, preoperative adjuvant chemotherapy followed by surgery is a well-established standard treatment for resectable, locally advanced esophageal squamous cell carcinoma. Therefore, developing an effective postoperative adjuvant therapy has been essential for improving oncological outcomes.Public Library of Science (PLoS), 2024年04月, PLOS ONE, 19(4) (4), e0299742 - e0299742研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年02月, Annals of Surgical Oncology, 31(6) (6), 4018 - 4018研究論文(学術雑誌)
- Background/Aim: The relationship between gastric cancer and oral health has been reported in several studies. This study aimed to determine the relationship between the postoperative prognosis of gastric cancer and oral health using preoperative tooth loss as a simple index. Patients and Methods: We conducted a single-center retrospective cohort study. Patients were divided into two groups according to the number of tooth losses. The survival curve was constructed using the Kaplan–Meier method. We also performed univariate and multivariate analyses of overall survival based on Cox proportional hazard regression to determine prognostic factors. Results: A total of 191 patients were divided into two groups: those with seven or more tooth losses and those with less than seven tooth losses. The three-year overall survival rate was 71.5% in the group with seven or more tooth losses and 87.0% in the group with less than seven tooth losses. The group with seven or more tooth losses had a significantly lower overall survival rate compared to the group with less than seven tooth losses (p=0.0014). However, in multivariate analysis, tooth loss was not identified as an independent prognostic factor whereas age, clinical T stage, CEA level, and serum albumin level were independent poor prognostic factors. Conclusion: Preoperative tooth loss was not a prognostic factor for gastric cancer after gastrectomy, but tooth loss may be a simple and useful method for evaluating frailty in patients.Anticancer Research USA Inc., 2024年01月, Cancer Diagnosis & Prognosis, 4(1) (1), 51 - 56研究論文(学術雑誌)
- Anticancer Research USA Inc., 2023年12月, Anticancer Research, 44(1) (1), 229 - 237研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2023年12月, Annals of Surgical Oncology, 31(4) (4), 2482 - 2489研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2023年12月, Surgery Today研究論文(学術雑誌)
- (株)癌と化学療法社, 2023年12月, 癌と化学療法, 50(13) (13), 1370 - 1373, 日本語
- (株)癌と化学療法社, 2023年12月, 癌と化学療法, 50(13) (13), 1374 - 1377, 日本語
- Anticancer Research USA Inc., 2023年11月, Anticancer Research, 43(12) (12), 5649 - 5656研究論文(学術雑誌)
- Abstract There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.Springer Science and Business Media LLC, 2023年10月, Scientific Reports, 13(1) (1)研究論文(学術雑誌)
- (株)メディカ出版, 2023年10月, 消化器ナーシング, (2023秋季増刊) (2023秋季増刊), 106 - 107, 日本語
- (株)メディカ出版, 2023年10月, 消化器ナーシング, (2023秋季増刊) (2023秋季増刊), 104 - 105, 日本語
- BACKGROUND/AIM: In pathology, the digitization of tissue slide images and the development of image analysis by deep learning have dramatically increased the amount of information obtainable from tissue slides. This advancement is anticipated to not only aid in pathological diagnosis, but also to enhance patient management. Deep learning-based image cytometry (DL-IC) is a technique that plays a pivotal role in this process, enabling cell identification and counting with precision. Accurate cell determination is essential when using this technique. Herein, we aimed to evaluate the performance of our DL-IC in cell identification. MATERIALS AND METHODS: Cu-Cyto, a DL-IC with a bit-pattern kernel-filtering algorithm designed to help avoid multi-counted cell determination, was developed and evaluated for performance using tumor tissue slide images with immunohistochemical staining (IHC). RESULTS: The performances of three versions of Cu-Cyto were evaluated according to their learning stages. In the early stage of learning, the F1 score for immunostained CD8+ T cells (0.343) was higher than the scores for non-immunostained cells [adenocarcinoma cells (0.040) and lymphocytes (0.002)]. As training and validation progressed, the F1 scores for all cells improved. In the latest stage of learning, the F1 scores for adenocarcinoma cells, lymphocytes, and CD8+ T cells were 0.589, 0.889, and 0.911, respectively. CONCLUSION: Cu-Cyto demonstrated good performance in cell determination. IHC can boost learning efficiencies in the early stages of learning. Its performance is expected to improve even further with continuous learning, and the DL-IC can contribute to the implementation of precision oncology.2023年08月, Anticancer research, 43(8) (8), 3755 - 3761, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. In recent years, the proportion of patients diagnosed with CRC at younger ages has increased. The clinicopathological features and oncological outcomes in younger patients with CRC remain controversial. We aimed to analyze the clinicopathological features and oncological outcomes in younger patients with CRC. METHODS: We examined 980 patients who underwent surgery for primary colorectal adenocarcinoma between 2006 and 2020. Patients were divided into two cohorts: younger (< 40 years old) and older (≥ 40 years old). RESULTS: Of the 980 patients, 26 (2.7%) were under the age of 40 years. The younger group had more advanced disease (57.7% vs. 36.6%, p = 0.031) and more cases beyond the transverse colon (84.6% vs. 65.3%, p = 0.029) than the older group. Adjuvant chemotherapy was administered more frequently in the younger group (50% vs. 25.8%, p < 0.01). Relapse-free survival and overall survival were similar between the groups at all stages. Moreover, in stages II and III they were also comparable, regardless of the administration of adjuvant chemotherapy. CONCLUSIONS: Younger patients with CRC have a prognosis equivalent to that of older patients. Further studies are needed to establish the optimal treatment strategies for these patients.2023年07月, International journal of colorectal disease, 38(1) (1), 191 - 191, 英語, 国際誌研究論文(学術雑誌)
- 2023年07月, Annals of surgical oncology, 30(7) (7), 4056 - 4057, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Retrosternal reconstruction has lower risks for severe postoperative morbidities, such as gastro-tracheal fistula or esophageal hiatal hernia. We have previously reported the laparoscopic retrosternal route creation (LRRC) method, but its safety and efficacy remain unclear. METHODS: In total, 374 patients with esophageal carcinoma who underwent minimally invasive McKeown esophagectomy in the prone position between 2010 and 2021 were retrospectively reviewed. We performed a propensity score-matched analysis with the simple, nearest-neighbor method and no calipers to compare postoperative outcomes and reconstructed gastric conduit functionality between patients who underwent LRRC and counterparts who underwent posterior mediastinal reconstruction. RESULTS: After matching, 62 patients were included in the laparoscopic retrosternal group (LR group) or posterior mediastinal group (PM group). No significant differences were observed between the groups, apart from the number of robot-assisted surgeries, the extent of lymph node dissection, and the method of cervical anastomosis. There were no significant differences in the incidence of Clavien-Dindo grade ≥ 2 complications. Gastro-tracheal fistula (n = 1) and esophageal hiatal hernia (n = 2) occurred in the PM group but not in the LR group. There were no differences in the incidence of pulmonary embolism between the groups (5% vs. 5%). The postoperative anastomotic stenosis rate was similar (16% vs. 27%, p = 0.192). Endoscopic findings of reflux esophagitis (modified Los Angeles classification ≥ M) at 1 year after surgery were significantly better in the LR group (p = 0.037). CONCLUSIONS: LRRC for gastric conduit reconstruction is safe and valuable. It is associated with good reconstructed gastric conduit function.2023年07月, Annals of surgical oncology, 30(7) (7), 4044 - 4053, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: There are several concerns about oncological contamination and technical difficulty in the laparoscopic approach for locally advanced gastric cancer. We aimed to determine the safety and usefulness of laparoscopic gastrectomy for patients with advanced gastric cancer with tumor depth greater than serosal invasion. PATIENTS AND METHODS: Sixty-two laparoscopic and 82 laparotomy gastric cancer cases surgically diagnosed as serosal or other organ invasions intraoperatively between 2011 and 2021 were included. The laparoscopic and open gastrectomy results were compared by propensity score matching using stage, preoperative chemotherapy, curative resection, surgical technique, and age as explanatory variables and laparoscopy and open resection as outcome variables. RESULTS: No difference in median operative time (341 vs. 386 minutes, p=0.24) was observed, but median blood loss (0 vs. 510 ml, p<0.001) and blood transfusion requirement (9.5 vs. 43%, p<0.001) were lower in the laparoscopic group. No difference was observed between the two groups regarding complications. Furthermore, 3-year overall survival was also similar (43 vs. 42%, p=0.74). CONCLUSION: The laparoscopic surgery results are comparable to those of open surgery in treating gastric cancer with T4a or greater depth. In addition, it is minimally invasive with less blood loss, making it a standard approach.2023年07月, Anticancer research, 43(7) (7), 3145 - 3152, 英語, 国際誌研究論文(学術雑誌)
- 2023年06月, Annals of surgical oncology, 30(6) (6), 3803 - 3804, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Although transanal total mesorectal excision (TaTME) is a promising treatment for low rectal cancer, it is considered technically demanding, and the number of cases required to become proficient in TaTME remains unknown. The purpose of this study was to assess the TaTME learning curve based on the total mesorectal excision completion time. STUDY DESIGN: This retrospective analysis comprised 128 individuals who received TaTME between September 2016 and December 2021. The cumulative sum method was used to generate the learning curve. The duration of the procedure from the beginning to the end of the circumferential rendezvous was used to define the total mesorectal excision completion time. RESULTS: The learning curve consists of 3 phases: phase I (learning phase: cases 1 to 38), phase II (consolidation phase: cases 39 to 70), and phase III (maturing phase: cases 71 to 128). As the phases varied, both the overall operative time and total mesorectal excision completion time decreased considerably. Through the 3 phases of TaTME, intraoperative adverse events decreased, and in phase III, none occurred. Only 1 instance of local recurrence occurred during phase III, and none occurred during phase I or II. CONCLUSIONS: After 70 operations, the surgeon could join the mastery phase of TaTME based on the total mesorectal excision completion time. After the mastering phase began, there were no intraoperative negative occurrences. From the beginning, the oncological safety could be guaranteed.2023年05月, Journal of the American College of Surgeons, 236(5) (5), 1054 - 1063, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Narrow pelvis, tumor diameter, and obesity have been reported as clinical variables correlated with the difficulty of conventional laparoscopic low anterior resection (Lap-LAR). A two-team transanal total mesorectal excision (TaTME) approach where the transabdominal and TaTME are performed simultaneously might reduce the difficulty associated with these factors. This study aimed to clarify the factors associated with the longer time required for TME (TME time) in conventional Lap-LAR and a two-team approach for TaTME. METHODS: We analyzed 52 patients with rectal carcinoma treated with Lap-LAR and 35 patients treated with TaTME. We performed simple linear regression analysis to assess the association between TME time and bony pelvic size using 3D pelvimetry, longest tumor diameter, and body mass index (BMI). RESULTS: Linear regression analysis demonstrated a highly significant association between TME time and obstetric conjugate (R2 = 0.098, P = .024) and BMI (R2 = 0.307, P < .001) in the Lap-LAR group, while no significant association was observed in the TaTME group. Male patients, who had a narrower bony pelvis and higher BMI than female patients, had longer TME time than female patients in the Lap-LAR group (213 minutes vs 172 minutes, P = .021), while the TME time of male and female patients did not differ in the TaTME group (122 minutes vs 108 minutes, P = .451). The TME time in the TaTME group was significantly shorter than that in the Lap-LAR group (121 minutes vs 197 minutes, P < .001). CONCLUSION: A two-team TaTME approach provided a shorter TME time compared to conventional Lap-LAR, regardless of pelvic size and BMI.2023年04月, Asian journal of endoscopic surgery, 16(2) (2), 189 - 196, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Esophagectomy for esophageal carcinoma is associated with higher morbidity and mortality rates than other gastrointestinal surgeries. Smoking is an established risk factor for postoperative complications after esophagectomy. This study aimed retrospectively to investigate the impact of smoking status on short- and long-term outcomes for patients undergoing thoracoscopic esophagectomy in the prone position (TEP) for esophageal carcinoma. METHODS: In this study, 234 patients with esophageal carcinoma who underwent TEP between 2012 and 2020 were divided into two groups based on smoking status (current or non-current smokers and the Brinkman index) by patients' declarations. Postoperative complications (Clavien-Dindo classification grade ≥2), overall survival (OS), and disease-free survival (DFS) were compared between smoking statuses. RESULTS: The rates of postoperative complications did not differ significantly between the two groups (current smoker vs non-current smoker; Brinkman index ≥800 vs <800). The rate of postoperative pneumonia was higher in the combination group of current and higher Brinkman index (≥800) smokers than in the other group (25.0 % vs 11.8 %; P = 0.036). Multivariate analysis showed that smoking status was an independent risk factor for postoperative pneumonia (hazard ratio, 0.41; 95 % confidence interval, 0.18-0.93; P = 0.037). According to the long-term outcomes, no significant differences in OS and DFS were observed between the smoking statuses. CONCLUSIONS: The combination of current smoking and heavy smoking history is a risk factor for postoperative pneumonia in patients who have esophageal carcinoma treated with TEP, although no correlation was observed between the long-term outcomes and smoking status.2023年04月, Annals of surgical oncology, 30(4) (4), 2202 - 2211, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Laparoscopic surgery for low rectal cancer is often challenging. Transanal total mesorectal excision (TaTME) and robotic surgery have been introduced to overcome the technical difficulties in laparoscopic surgery and achieve more favorable outcomes. Hybrid robotic surgery, which combines TaTME with the abdominal robotic approach, incorporates the advantages of each of these surgical techniques and might achieve less invasive and safer surgery. This study evaluated the safety and feasibility of hybrid robotic surgery with TaTME (hybrid TaTME). METHODS: We retrospectively reviewed 162 TaTME cases performed at our department from September 2016 to May 2022. Among them, 92 cases of conventional TaTME and 30 of hybrid TaTME were eligible. We used propensity score matching analysis (PSM) to adjust for patients' characteristics and compared the short-term outcomes of the two treatment groups. RESULTS: Twenty-seven cases in each group were extracted using PSM. The operation time in hybrid TaTME was comparable to that in conventional TaTME. There was no significant difference in the postoperative hospital stay between the two groups. Other intra- and post-operative outcomes were also comparable between the two groups. Furthermore, no significant differences were observed between the two groups in the curative resection and recurrence rates. CONCLUSION: Hybrid TaTME for low rectal cancer was as favorable as conventional TaTME in producing satisfactory short-term outcomes. However, furthermore, larger-scale studies conducted over longer study periods are needed to evaluate the validity of the findings.2023年03月, Langenbeck's archives of surgery, 408(1) (1), 129 - 129, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: This study aimed to compare motions of the laparoscope tip during a laparoscopic task in a training box using a recent joystick-guided robotic scope holder to those manipulated by human scopists. We hypothesized that laparoscopic manipulation could be positively affected by robotic scope holders due to the elimination of unintentional movement. METHODS: Twelve surgeons participated as operators, and eight medical doctors participated in this study. Among the human scopists, five were trained surgeons and three were novices who had no experience with laparoscopic surgery. A validated laparoscopic task was used to evaluate the path length of the laparoscope tip using an optical position tracker and operative time. The operators performed the designated camera task under three different laparoscopic manipulations: using a joystick-guided robotic scope holder, expert human scopists, and novice scopists. RESULTS: The median path lengths (cm) of the laparoscopic tip were 94.0, 110.0, and 122.2 in the robotic scope holder, expert, and novice groups, respectively. The path lengths in the robotic scope holder group were significantly shorter than those in the other groups (P < .01). The median operative times (seconds) were 136.6, 66.4, and 62.3 in the robotic scope holder, expert, and novice groups, respectively. The operative time of the robotic scope holder group was significantly longer than that of the other groups (P < .001). CONCLUSION: A robotic scope holder can provide shorter camera movement owing to the stable holding and intentional scope manipulation by the operator, although it requires a longer operative time than a human assistant.2023年02月, Surgical innovation, 15533506231157039 - 15533506231157039, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Although lateral pelvic lymph node dissection (LLND) might be an effective approach for patients with rectal cancer with lateral lymph node metastasis, it is technically challenging because of the anatomical complexity and location of the deep pelvis. An assistance by transanal approach might be useful for a successful LLND. METHODS: From September 2016 to May 2021, 39 patients with low rectal cancer underwent transanal total mesorectal excision with LLND. Among them, 18 patients underwent LLND using a conventional laparoscopic approach alone, while the remaining 21 underwent LLND using both conventional and transanal approaches. Their clinical outcomes were retrospectively compared. RESULTS: The operation time for LLND on each side was significantly shorter in the transanal group (105 min vs. 54 min, P < 0.001). The intraoperative blood loss was also significantly less in the transanal group (40 g vs. 0 g, P = 0.031). The rate of overall postoperative complications ≥ grade II according to the Clavien-Dindo classification was significantly less in the transanal group (66.7% vs. 28.6%, odds ratio: 5.000, 95% confidence intervals: 1.313-19.047, P = 0.040). The number of harvested lateral lymph nodes in both groups was similar (8.5 vs. 8, P = 0.544). CONCLUSION: The transanal approach for LLND reduced operative time, blood loss, and morbidity compared with the conventional approach alone in a cohort of patients with rectal cancer.2023年02月, Surgical endoscopy, 37(2) (2), 1562 - 1568, 英語, 国際誌研究論文(学術雑誌)
- Although a therapeutic response to neoadjuvant chemoradiotherapy (NACRT) is important to improve oncological outcomes after surgery in patients with locally advanced rectal cancer, there is no reliable predictor for this. The Wnt/β-catenin signal is known to be crucial for the tumorigenesis of colorectal cancer. This study aimed to investigate the association of Wnt/β-catenin signal activation with a pathological response to NACRT. The immunohistochemical expression of nuclear and membranous β-catenin was analyzed in biopsy samples obtained from 60 patients with locally advanced rectal cancer who received curative surgery following NACRT. The association of Wnt/β-catenin signal activation with their clinical outcomes was investigated. Notably, the body mass index of these patients was significantly higher in the low nuclear β-catenin expression group. Moreover, patients in the high nuclear β-catenin expression group tended to have more advanced disease and a higher rate of positive vascular invasion than those in the low expression group. Furthermore, the rate of good histological responses was significantly higher in the low nuclear β-catenin expression group (72% vs. 37.1%, p < 0.01). Overall, relapse-free survival tended to be better in patients with low nuclear/high membranous β-catenin expression (n = 9) than in other individuals (n = 51) (p = 0.093 and p = 0.214, respectively). Activation of the Wnt/β-catenin signal pathway represented by nuclear β-catenin accumulation was significantly associated with a poor response to NACRT in patients with rectal cancer. Analysis of nuclear β-catenin accumulation before starting treatment might help predict the therapeutic response to NACRT.2023年01月, Biomedicines, 11(1) (1), 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: Neoadjuvant chemotherapy (NAC) for advanced gastric cancer (GC) and esophagogastric junction cancer (EGC) is expected to effectively control the tumor; however, histological tumor response and immune function markers as prognostic factors for NAC remain unknown. This study assessed the prognostic significance of histological response and immune function markers in patients undergoing NAC for GC and EGC. PATIENTS AND METHODS: Forty-two patients who underwent NAC followed by surgical resection for operable advanced GC or EGC from January 2007 to December 2019 were divided into two groups based on histological response. Overall survival (OS), tumor response, and immune function markers, such as the neutrophil/lymphocyte ratio (NLR), were the outcomes analyzed. RESULTS: The 5-year OS for Grade 2b-3 (n=10, responder group) according to the Japanese Gastric Cancer Classification was 72.0% with a favorable prognosis, compared with 33.3% for Grade 0-1a (n=18), and 46.8% for Grade 1b-2a (n=14) in the non-responder group. There was no significant difference in the background between the two groups regarding clinical status or immune function markers. In a multivariate analysis of immune function markers, the NLR value before NAC was significantly associated with prognosis (p=0.048). Patients with an NLR value <3.4 had a favorable OS (p=0.03). CONCLUSION: Histological response scores for Grade 2b or higher may help predict a favorable prognosis for patients undergoing NAC for advanced GC and EGC. The outcomes may be further improved by considering NLR values.2023年, In vivo (Athens, Greece), 37(1) (1), 378 - 384, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Rectal or anal canal adenocarcinoma with inguinal lymph node metastasis (ILNM) is rare and is associated with poor prognostic outcomes. This study aimed to elucidate the clinical significance of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for rectal or anal canal adenocarcinoma with clinically suspected ILNM. METHODS: This study enrolled 15 consecutive patients who underwent neoadjuvant therapy and curative resection for rectal or anal canal adenocarcinoma with clinically suspected ILNM between 2005 and 2019 at a single institution. Inguinal lymph node dissection was selectively performed on the side of suspected metastasis before neoadjuvant therapy. Short- and long-term outcomes were retrospectively reviewed. RESULTS: Out of the15 patients, 11 were treated with neoadjuvant chemoradiation, three with chemotherapy, and one with chemoradiation followed by chemotherapy. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) scans were performed after neoadjuvant therapy in 14 patients. Five patients had negative FDG accumulation in inguinal lymph nodes on FDG-PET scan, and their inguinal lymph nodes were also pathologically negative for metastasis. Of the nine patients who had positive FDG accumulation, four had pathologically positive inguinal lymph nodes. Seven patients (46.7%) had inguinal seroma postoperatively. Five-year-overall survival was 77.5%, and 5-year-relapse-free survival was 64.2%. No patient had a recurrence in the inguinal region. CONCLUSION: In patients with rectal or anal canal adenocarcinoma associated with clinical ILNM, radical resection with neoadjuvant therapy provides a good long-term survival.2022年12月, Langenbeck's archives of surgery, 408(1) (1), 2 - 2, 英語, 国際誌研究論文(学術雑誌)
- (株)癌と化学療法社, 2022年12月, 癌と化学療法, 49(13) (13), 1711 - 1713, 日本語
- [A Case of Pathological Complete Response after Conversion Surgery for HER2-Positive Advanced Gastric Cancer with Multiple Distant Metastases].The patient is a 70's man. Esophagogastroduodenoscopy and contrast-enhanced CT scan of the abdomen revealed gastric cancer, 2 liver metastases, and peritoneal dissemination. He was diagnosed with unresectable advanced gastric cancer and received 5 courses of chemotherapy(CapeOX plus T-mab). The primary tumor size had reduced, and liver metastases and peritoneal dissemination were not detectable, so laparoscopic distal gastrectomy and partial hepatectomy were performed. Histopathological findings revealed no viable cancer cells in either the primary tumor or the hepatic resection site, and the histological response was Grade 3. The patient has been recurrence-free for 6 months since the surgery. Even in Stage Ⅳ gastric cancer with multiple distant metastases, long-term survival may be expected by conversion surgery after response to chemotherapy.2022年12月, Gan to kagaku ryoho. Cancer & chemotherapy, 49(13) (13), 1711 - 1713, 日本語, 国内誌研究論文(学術雑誌)
- PURPOSE: Despite the increasing incidence of adenocarcinoma of the esophagogastric junction, laparoscopic proximal gastrectomy with lower esophagectomy (PGLE) is not widely accepted owing to the lack of standardized reconstruction techniques. In this study, we developed a new reconstruction method named y-shaped overlap esophagogastric tube reconstruction, which reproduces an angle of His and a pseudo-fornix, to be used in laparoscopic transhiatal PGLE. This study aimed to determine the feasibility of this novel reconstruction method. METHODS: This retrospective study included the analysis of short- and mid-term surgical outcomes of 30 consecutive patients with Siewert type II esophagogastric junction adenocarcinoma who underwent laparoscopic PGLE with y-shaped overlap esophagogastric tube reconstruction from April 2015 to August 2020. A novel method was used to form a 6-cm pseudo-fornix and an angle of His using the distal esophagus and a long gastric tube. RESULTS: The median operation time was 369 min, and the median blood loss was 28 mL. The median follow-up period after surgery was 37 months. Although two patients experienced postoperative anastomotic leakage, none of the patients developed stenosis. One patient experienced moderate reflux symptoms, whereas four patients developed moderate reflux esophagitis based on the 1-year follow-up endoscopic examination; the condition of all patients could be efficiently controlled with medication. CONCLUSION: The short- and mid-term surgical outcomes of y-shaped overlap esophagogastric tube reconstruction reflected the feasibility of this simple technique and suggested its potential utility as a reconstruction alternative for Siewert type II tumors.2022年12月, Langenbeck's archives of surgery, 407(8) (8), 3915 - 3915, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Many patients with esophageal squamous cell carcinoma (ESCC) have obstructive ventilatory disorder (OVD), which is considered a risk factor for postoperative pneumonia. It has been reported that thoracoscopic esophagectomy in the prone position (TEP) is less invasive and is associated with fewer postoperative respiratory complications compared with open esophagectomy. This matched-cohort study aimed to elucidate the safety and oncologic outcomes of ESCC patients with OVD who undergo TEP. METHODS: In this matched-cohort study, 237 patients with ESCC who underwent TEP between 2010 and 2018 were divided into two groups based on forced expiratory volume in 1 s/forced vital capacity. Postoperative complications (Clavien-Dindo classification grade II or higher), overall survival (OS), and disease-free survival (DFS) were compared between the two groups. RESULTS: Based on their propensity scores, 75 patients with normal respiratory function (NRF) and 75 with OVD were selected. The rates of postoperative pneumonia were not significantly different between the two groups (NRF group vs OVD group: 18.7% vs 18.7%; P = 1.000). The rates of recurrent laryngeal nerve palsy and anastomotic leakage were also not significantly different (NRF group vs OVD group: 12.0% vs 18.7%, P = 0.365; 18.7% vs 18.7%, P = 1.000). The 5-year OS and DFS rates in the NRF vs OVD groups were 66.2% vs 54.9% and 63.5% vs 52.9%, respectively, with no significant differences (P = 0.421, 0.197). CONCLUSIONS: TEP can be safely performed on ESCC patients with OVD and can result in an oncological efficiency equal to that of the NRF group.2022年12月, Surgical endoscopy, 36(12) (12), 8834 - 8842, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: Although survival in cases with early recurrence after curative resection of colorectal cancer has been persistently poor, the risk factors for early recurrence remain unknown. PATIENTS AND METHODS: A total of 1,043 patients with stage I-III colorectal cancer underwent curative resection at Kobe University Hospital between April 2007 and September 2020. Of these, 122 patients developed recurrence: 57 had early recurrence (<1 year after surgery) and 65 patients had late recurrence (≥1 year after surgery). The clinicopathological features were compared between the groups and the risk factors for early recurrence were analyzed. RESULTS: Overall survival both from the date of recurrence and from the date of surgery were significantly worse in the early recurrence group. The proportion of the patients with ≥100 g of intraoperative blood loss, blood transfusion, and postoperative complications were significantly higher in the early recurrence group. R0 resection was achieved more frequently in the late recurrence group. Multivariate analysis revealed that no adjuvant chemotherapy, elevated preoperative CA19-9, blood transfusion, and the occurrence of the postoperative complication were independent risk factors for early recurrence. CONCLUSION: Early recurrence after curative resection of colorectal cancer was associated with worse overall survival. Adjuvant chemotherapy might be beneficial for patients with risk factors of early recurrence to improve prognosis.2022年11月, Anticancer research, 42(11) (11), 5553 - 5559, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: No study has focused on the safety and feasibility of our previously developed open-window suturing technique to close mucosal defects on the pancreatic side after endoscopic submucosal dissection from the opened duodenal wall. This study aimed to evaluate the safety and usefulness of laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side of the duodenum. METHODS: This retrospective study included 61 consecutive patients who underwent surgery during August 2014-November 2021. After dissection when the tumor was on the pancreatic side, we sutured the mucosal defect from the opened duodenal wall. A preoperative endoscopic pancreatic stent was placed for tumors within 1 cm of the ampulla of Vater. The surgical outcomes were compared between tumors on the pancreatic and non-pancreatic sides. RESULTS: There were 27 and 34 patients with tumors on the pancreatic and non-pancreatic sides, respectively. The patient characteristics were similar. Preoperative pancreatic stents were placed in four patients in the pancreatic side group. The median operative time was significantly longer on the pancreatic side than in the non-pancreatic side group (241 vs. 209 min, P = 0.02). In one patient in the pancreatic side group, an intraoperative injury of the ampulla of Vater was successfully treated with intraoperative management. There were no significant differences in the incidence of postoperative grade II or higher complications between the groups. CONCLUSIONS: Laparoscopic endoscopic cooperative surgery for duodenal tumors for treating superficial non-ampullary duodenal epithelial tumors on the pancreatic side is safe and feasible.2022年11月, Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 26(11) (11), 2266 - 2273, 英語, 国際誌研究論文(学術雑誌)
- 2022年10月, Annals of surgical oncology, 29(11) (11), 6867 - 6868, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Multidisciplinary treatment combining neoadjuvant treatment (NAT) and surgery has slightly improved the prognosis of patients with esophageal squamous cell carcinoma (ESCC). Although various biomarkers targeting nutrition and inflammation are associated with cancer prognosis, most studies have focused on conditions prior to NAT. Developing real-time and sensitive biomarkers that monitor changes in systemic conditions during NAT is important. We established a novel nutritional and inflammatory index, represented as the albumin to derived neutrophil-to-lymphocyte ratio (Alb-dNLR), and calculated the change in Alb-dNLR (ΔAlb-dNLR) during neoadjuvant chemotherapy (nCT). In this study, we aimed to evaluate whether ΔAlb-dNLR is associated with prognosis in patients with ESCC. METHODS: We investigated 172 patients who underwent nCT before esophagectomy between April 2010 and March 2018. The dNLR was calculated as the ratio of neutrophil count to (white blood cell count - neutrophil count), Alb-dNLR was calculated by dividing the serum albumin level by the dNLR, and ΔAlb-dNLR was evaluated by dividing the post-Alb-dNLR by the pre-Alb-dNLR. Patients were divided into 'high' and 'low' groups according to the ΔAlb-dNLR. RESULTS: Thirty-nine patients (22.7%) had a low ΔAlb-dNLR (≤ 0.8), and the 5-year overall survival (OS) rates in patients with low and high ΔAlb-dNLR were 38.1% and 53.6%, respectively (p = 0.0072). Multivariate analyses demonstrated that estimated blood loss (p = 0.044), pathological T stage (p = 0.0005), pathological N stage (p = 0.017), and ΔAlb-dNLR (p = 0.005) were independent prognostic factors for OS. CONCLUSIONS: ΔAlb-dNLR is a useful prognostic factor for OS in patients with ESCC receiving nCT.2022年10月, Annals of surgical oncology, 29(11) (11), 6860 - 6866, 英語, 国際誌研究論文(学術雑誌)
- 2022年10月, Annals of surgical oncology, 29(11) (11), 6869 - 6870, 英語, 国際誌研究論文(学術雑誌)
- The risk factors for delayed gastric emptying (DGE) following gastrectomy are unclear. This study aimed to investigate the risk factors for DGE and the severity of DGE. We retrospectively evaluated 412 patients who underwent gastrectomy for gastric cancer between 2011 and 2019. The cases were classified into the DGE (n = 27) and non-DGE (n = 385) groups; the DGE group was further classified into two subgroups based on nasogastric tube insertion as an indicator of severity. For determining the relationship between resected stomach volume and DGE, we calculated the area of each surgical specimen using the ImageJ software. Female sex (odds ratio [OR] 2.55; 95% confidence interval [CI] 1.09-5.93; P = 0.03), diabetes (OR 2.38; 95% CI 1.02-5.57; P = 0.03), and distal gastric tumors (OR 2.61; 95% CI 1.10-6.19; P = 0.02) were identified as independent risk factors by multivariate analysis. The duration of hospital stay was longer in the DGE group than in the non-DGE group (29 vs. 15 days, P < 0.01). Overall, 24 cases of DGE (89%) were found in more than 1 week following surgery. No correlation was observed between clinical features and the severity of DGE. The resected area in the DGE group was significantly larger than that in the non-DGE group (198.0 vs. 173.9 cm2, P = 0.03). In conclusion, DGE was frequently observed in females and in patients with diabetes and distal gastric tumors. Most of the DGE cases occurred after 7-14 days of surgery, patients who are discharged early should be informed to seek hospitalization if they have symptoms caused by DGE.2022年09月, Scientific reports, 12(1) (1), 15903 - 15903, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: The eighth edition of the American Joint Committee on Cancer (AJCC) tumor node metastasis (AJCC-TNM 8th) system adopted the newly separate post-neoadjuvant pathologic stage group (ypTNM). However, it is not compatible with the Japanese pathologic classification after neoadjuvant chemotherapy (JPN-CT-pTNM). The aim of this study is to clarify the subjects of the AJCC-ypTNM 8th and propose a unification of the AJCC and Japanese systems to create novel AJCC-CT-pTNM 8th. METHODS: Participants were 304 esophageal squamous cell carcinoma (ESCC) patients who underwent neoadjuvant chemotherapy followed by 3 stage esophagectomy between 2010 and 2019. Predictive probabilities of pN, pM in AJCC-ypTNM 8th and JPN-CT-pTNM 11th systems were evaluated to propose novel system. RESULTS: In training data from 234 patients, the overall survival rate was statistically better for ypStage IIIA than ypStage II (P = 0.040) resulting in staging inversion in AJCC-ypTNM 8th. Predictive probability of pathological N status in AJCC-ypTNM 8th (Akaike Information Criterion: AIC = 979.53) was superior to that in JPN-CT-pTNM 11th (AIC = 999.07). In AJCC-ypTNM 8th, 71% (15/21) of ypM1 diseases were supraclavicular lymph nodes (No. 104 L/N as regional in JPN-CT-pTNM 11th) metastases with considerably good prognosis. The predictive probability of the novel AJCC-CT-pTNM 8th [unification of ypStage II and IIIA, conversion of supraclavicular L/Ns metastases from ypM to ypN] (AIC = 1054.24) was superior to that of the existing AJCC-ypTNM 8th (AIC = 1070.74). The feasibility of novel system was validated using test data from 70 patients. CONCLUSIONS: Unification of the AJCC and Japanese systems yields a simpler and more precise predictive system after neoadjuvant chemotherapy.2022年08月, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 48(8) (8), 1760 - 1767, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Postoperative complications affect long-term prognosis in patients with esophageal squamous cell carcinoma (ESCC). Although a comprehensive estimator can predict long-term prognosis, the Clavien-Dindo classification system, a widely used approach to evaluate complications, assesses each complication individually. We aimed to clarify the utility of the comprehensive complication index (CCI) on predicting the overall survival (OS) of patients with ESCC following minimally invasive esophagectomy (MIE). METHODS: This was a retrospective study of patients undergoing MIE for ESCC in the prone position between January 2011 and December 2018. Multivariate analyses using the Cox proportional hazards model were performed to determine independent risk factors for OS. RESULTS: The study cohort included 229 patients who were categorized into patients with CCI values of ≥ 33.7 (CCI high) and < 33.7 (CCI low) by receiver-operating characteristic (ROC) curve analysis. There were no significant differences between the two groups according to clinicopathological factors, such as sex, age, tumor location, tumor depth, lymph node metastasis, and neoadjuvant chemotherapy. The intraoperative transfusion rate in the CCI high group was significantly higher than in the CCI low group. The 5 year OS rate was significantly lower in the CCI high group than in the CCI low group (49.5% vs. 65.7%, p = 0.030). By multivariate analyses, age, tumor depth, lymph node metastasis, and the CCI were independent predictors of OS. CONCLUSIONS: Comprehensive assessment of postoperative complications using the CCI was useful in predicting OS of patients undergoing MIE for the ESCC.2022年07月, Esophagus : official journal of the Japan Esophageal Society, 19(3) (3), 410 - 416, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: Technical difficulties are occasionally encountered when performing conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy in patients with a narrow thoracic cavity. Thoracic cavity-to-cage ratio is an indicator of thoracic cavity length. We hypothesized that the thoracic cavity-to-cage ratio could be a predictor of technical difficulties in conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy. METHODS: We evaluated 340 patients who underwent minimally invasive esophagectomy for esophageal squamous cell carcinoma between April 2010 and March 2021. Thoracic cavity-to-cage ratio was calculated as the diameter of the thoracic cavity to that of the thoracic cage at the brachiocephalic vein, tracheal bifurcation, and inferior right pulmonary vein levels. Moreover, thoracic cavity-to-cage ratio score, which is an indicator of the whole thoracic cavity length based on the thoracic cavity-to-cage ratio at the 3 levels, was defined. The thoracic procedure time was considered an indicator of surgical difficulty. RESULTS: We divided the patients into the conventional minimally invasive esophagectomy (n = 295) and robot-assisted minimally invasive esophagectomy (n = 45) groups. The patients in each group were divided into 2 cohorts according to median thoracic procedure time. Based on multivariate analysis, body mass index (P = .0007), clinical N stage (P = .0191), and thoracic cavity-to-cage ratio score (P = .0005) were independent factors for thoracic procedure time in the conventional minimally invasive esophagectomy group. Moreover, thoracic cavity-to-cage ratio at the tracheal bifurcation level (P = .0331) was the only independent factor for thoracic procedure time in the robot-assisted minimally invasive esophagectomy group. CONCLUSION: Thoracic cavity-to-cage ratio could be a predictor of technical difficulties in both conventional minimally invasive esophagectomy and robot-assisted minimally invasive esophagectomy.2022年07月, Surgery, 172(1) (1), 145 - 149, 英語, 国際誌研究論文(学術雑誌)
- (株)南江堂, 2022年06月, 外科, 84(7) (7), 715 - 718, 日本語
- BACKGROUND: Minimally invasive esophagectomy (MIE) for esophageal cancer patients with sarcopenia is associated with a high risk of perioperative complications; however, the relationship between sarcopenia and the survival of esophageal cancer patients remains controversial. In this study, we aimed to develop a stratifying marker for sarcopenia to precisely predict patients' prognosis. METHODS: We retrospectively studied 135 patients who underwent thoracoscopic esophagectomy at Kobe University Hospital from 2011 to 2015 and who were preoperatively diagnosed with or without sarcopenia based on the Asian Working Group for Sarcopenia index. Creatinine levels and albumin as measures of skeletal muscle volume and nutritional status, respectively, were used to develop a marker to be used for stratifying sarcopenic patients based on prognosis. RESULTS: Of the 135 patients, 35 were diagnosed with sarcopenia and 100 were not. We combined the creatinine and albumin levels (Cr × Alb) as a stratifying marker for sarcopenia, and extracted sarcopenic patients with values below the Cr × Alb cut-off as the actual sarcopenic group. The 5-year overall survival (OS) rates of the actual and non-actual sarcopenic groups were 28.9% and 58.9%, respectively (p = 0.0005), and the 5-year disease-free survival rate of the actual sarcopenic group was 34.1%, and 62.8% (p = 0.0106) for the non-actual sarcopenic group. This stratified sarcopenia model was an independent prognostic factor and was superior to sarcopenia alone for OS. CONCLUSIONS: In patients undergoing MIE, preoperative measurement of Cr × Alb may be a prognostic stratification marker for patients with sarcopenia.2022年06月, Annals of surgical oncology, 29(6) (6), 3670 - 3681, 英語, 国際誌研究論文(学術雑誌)
- 2022年05月, Langenbeck's archives of surgery, 英語, 国際誌
- Although transperineal minimally invasive abdominoperineal resection (tp-APR) based on the concept of transanal total mesorectal excision has recently been used for rectal cancer, the operative procedure has not been standardized to date due to its technical difficulty. The tp-APR procedure used by the authors for a male patient with low rectal cancer is presented in this video.2022年05月, Annals of surgical oncology, 29(5) (5), 3065 - 3065, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant disease. This study examined whether the platelet-to-lymphocyte ratio (PLR) can be used as a biomarker to evaluate prognosis in patients with advanced ESCC following neoadjuvant chemotherapy (NAC) and undergoing minimally invasive esophagectomy (MIE). PATIENTS AND METHODS: We examined 174 patients between January 2010 and December 2015 at the Kobe University. Of these, 121 were treated with NAC. The PLR cutoff was determined through receiver-operating characteristic curve analysis. Univariate and multivariate analyses were conducted to identify prognostic factors for overall survival (OS). RESULTS: The PLR cutoff for OS in 121 patients was 169.6. Patients with PLR ≥169.6 had worse 5-year OS rates (31.1%) than those with a PLR <169.6 (61.1%, p=0.001). Multivariate analysis revealed that a PLR of ≥169.6 was an independent factor for poor prognosis. CONCLUSION: PLR is an independent prognostic factor for patients with ESCC after NAC and MIE.2022年05月, Anticancer research, 42(5) (5), 2775 - 2782, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Multidisciplinary treatment for esophageal squamous cell carcinoma (ESCC) has improved outcomes, but the prognosis for ESCC remains poor. Nutritional and inflammatory indicators are reported to be associated with cancer prognosis. The combination of albumin and the derived neutrophil-to-lymphocyte ratio (Alb-dNLR) score was established to measure the immune system and nutritional status. The authors hypothesized that the Alb-dNLR score could be a new reliable prognostic factor for ESCC patients. METHODS: The study evaluated 269 patients who underwent esophagectomy between April 2010 and March 2018, including 185 patients who received neoadjuvant chemotherapy. The Alb-dNLR score was calculated using serum albumin and the dNLR. The dNLR was calculated as neutrophils to (leukocyte-neutrophil count). The cutoff values of the albumin and dNLR for overall survival (OS) were determined using the receiver operating characteristic curve. Patients were divided into "high" and "low" groups according to the Alb-dNLR score. RESULTS: A high Alb-dNLR score was found in 61 cases (22.7%). The 5-year OS was 34% in the high Alb-dNLR group and 66.2% in the low Alb-dNLR group (p < 0.0001). The 5-year cause-specific survival (CSS) was 51.5% in the high Alb-dNLR group and 74.7% in the low Alb-dNLR group (p < 0.0001). Multivariate analyses demonstrated that the Alb-dNLR score was an independent prognostic factor for OS (hazard ratio [HR], 2.198; 95% confidence interval [CI], 1.460-3.263; p = 0.0002) and CSS (HR, 1.733; 95% CI, 1.035-2.835; p = 0.0371). CONCLUSIONS: The Alb-dNLR score is an extremely useful, easy-to-use parameter to predict OS and CSS for ESCC patients.2022年04月, Annals of surgical oncology, 29(4) (4), 2663 - 2671, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: Laparoscopic local resection for gastrointestinal stromal tumors (GISTs) near the esophagogastric junction (EGJ) increases the risk of injuring the EGJ. We investigated the safety of laparoscopic local resection for GISTs near the EGJ according to the distance from the EGJ to the tumor edge. METHODS: We retrospectively evaluated 40 patients who had undergone laparoscopic local resection for GISTs near the EGJ between January 2009 and December 2019. After excluding 1 patient who had undergone right colectomy at the same time, 39 patients were classified according to distance of the GIST from the EGJ in the Near group (0-2.0 cm; n = 16) and the Far group (2.1-5.0 cm; n = 23). RESULTS: We found no marked differences in the operation time, blood loss, length of postoperative hospital stay, or postoperative complication rate in the two groups. Anastomotic leakage occurred with a tumor located on the EGJ. Three tumors recurred in the Near group, and all of them were located on the EGJ. CONCLUSION: Except for GISTs located on the EGJ, laparoscopic local resection for GISTs near the EGJ can be performed safely with few postoperative complications and a low risk of recurrence.2022年03月, Surgery today, 52(3) (3), 395 - 400, 英語, 国内誌研究論文(学術雑誌)
- BACKGROUND: This study aimed to identify prognostic factors for adenocarcinoma of the esophagogastric junction (AEG) in Siewert type II and characterize the population whose prognosis is expected to improve. PATIENTS AND METHODS: We retrospectively reviewed a database of 68 AEG type II patients who had undergone surgical curative resection without preoperative treatment. RESULTS: Although patients with pathological N0 (pN0) showed favorable 3-year disease-free survival (91%), patients with pN1-3 had poor outcomes (42%, 23%, and 10%). Multivariate analyses showed that the only independent prognostic factor was lymph node metastasis, and that tumor depth (cT3-4) and tumor size (≥4 cm) were correlated closely with lymph node metastasis. CONCLUSION: Surgical curative resection without preoperative treatment is insufficient to treat AEG type II with lymph node metastasis. Among AEG patients, those with the high-risk factors of preoperative tumor depth (T3-4) or/and size (≥4 cm) might need intensive multimodal treatment, including perioperative adjuvant chemotherapy.2022年02月, Anticancer research, 42(2) (2), 1051 - 1057, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: We conducted a prospective clinical control study to identify the best imaging technology among three-dimensional (3-D) high-definition (HD) stereovision and two-dimensional (2-D) ultra-high-resolution (4 K) technology and confirm their effects on surgical outcomes of laparoscopic gastrectomy for gastric cancer. METHODS: From April 2018 to August 2019, 50 patients were randomly classified into two groups based on the imaging technology (3-D/HD group = 25, 2-D/4 K = 25). After excluding eight patients based on laparoscopic findings, 42 patients were analyzed (3-D/HD group = 21, 2-D/4 K = 21). The primary endpoint was the operative time; the secondary endpoints were blood loss, postoperative infectious complications, and postoperative hospital stay. RESULTS: The patients' backgrounds were similar (sex, age, body mass index [BMI], stage, procedure, and extent of lymph node dissection). There were no significant differences in operative time (252 vs. 238 min, P = 0.70), total blood loss, postoperative infectious complications, and postoperative hospital stay between the two groups. However, video analysis of surgeries revealed a significantly shortened median operative time (18 vs. 25 min, P = 0.04) in the suturing step with 3-D/HD; the median number of camera cleaning procedures during suprapancreatic lymph node dissection was significantly lower with 2-D/4 K than with 3-D/HD (n = 4.4 vs. 2.8, P = 0.02). CONCLUSION: 3-D/HD and 2-D/4 K laparoscopic radical gastrectomies provide similar surgical outcomes. However, the 3-D monitor reduces suturing time during reconstruction, while the 4 K monitor reduces the number of camera cleaning procedures during lymphadenectomy. TRIAL REGISTRATION: Registered in the University Hospital Medical Information Network Clinical Trials Registry (identification number 000029227).2022年02月, Langenbeck's archives of surgery, 407(1) (1), 105 - 112, 英語, 国際誌研究論文(学術雑誌)
- 2022年01月, Annals of surgical oncology, 29(4) (4), 2672, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND/AIM: The safety of gastrectomy for patients receiving antithrombotic agents remains unclear. This retrospective cohort study sought to compare outcomes between patients who did and did not receive antithrombotic agents. PATIENTS AND METHODS: This single-center retrospective cohort study included 548 patients who underwent gastrectomy for primary gastric adenocarcinoma from January 2011 to December 2019. The surgical outcomes were compared between two groups according to whether they received antithrombotic therapy (n=121) or not (n=427). RESULTS: Among the entire cohort, the patients in the antithrombotic therapy group were significantly older than those who did not receive this therapy and had significantly higher postoperative complication rates than those who did not (33.1% vs. 23.9%; p=0.046). However, after propensity score matching, no significant difference in the postoperative complication rate was observed between the two groups. CONCLUSION: Despite having a high risk for postoperative complications, patients receiving antithrombotic therapy can safely undergo gastric resection.2022年, Cancer diagnosis & prognosis, 2(2) (2), 210 - 215, 英語, 国際誌研究論文(学術雑誌)
- BACKGROUND: Lateral pelvic lymph node metastasis impairs the oncological outcomes of patients with rectal cancer. Although lateral pelvic lymph node dissection (LLND) might be an effective procedure for such patients, the associated risk factors for postoperative complications are unknown. PATIENTS AND METHODS: The operative outcomes of 21 patients undergoing unilateral LLND and 26 patients undergoing bilateral LLND for rectal cancer were compared. The risk factors for complications were evaluated using a logistic regression model. RESULTS: Univariate and multivariate analyses revealed that a longer operative time (≥480 min) was the most important risk factor for grade II or more postoperative complications according to the Clavien-Dindo classification (odds ratio=6.58; 95% confidence interval=1.35-32.1; p=0.020). A bilateral procedure was not a significant risk factor for postoperative complications. CONCLUSION: Surgeons should make efforts to shorten the operative time to reduce the risk of postoperative complications.2021年11月, Anticancer research, 41(11) (11), 5599 - 5604, 英語, 国際誌研究論文(学術雑誌)
- 2021年10月, 医学と薬学, 78(10) (10), 1167 - 1173, 日本語【胃癌の全て】胃癌の周術期化学療法研究論文(学術雑誌)
- 2021年06月, 日本消化器外科学会雑誌, 54(6) (6), 397 - 407膵デスモイド腫瘍に対して腹腔鏡下膵体尾部切除を施行した1例(原著論文/症例報告)
- The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the development of multiple types of cancer, and its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an orally active selective inhibitor of the interaction between β-catenin and CREB binding protein, which is part of the Wnt/β-catenin signaling pathway, disrupts the Wnt/β-catenin signaling pathway in HEK293 and adenomatous polyposis coli (APC)-mutated human gastric cancer ECC10 cells. It also inhibited tumor growth in an ECC10 xenograft model and suppressed polyp formation in the intestinal tract of ApcMin /+ mice, in which mutation of Apc activates the Wnt/β-catenin signaling pathway. E7386 demonstrated antitumor activity against mouse mammary tumors developed in mouse mammary tumor virus (MMTV)-Wnt1 transgenic mice. Gene expression profiling using RNA sequencing data of MMTV-Wnt1 tumor tissue from mice treated with E7386 showed that E7386 downregulated genes in the hypoxia signaling pathway and immune responses related to the CCL2, and IHC analysis showed that E7386 induced infiltration of CD8+ cells into tumor tissues. Furthermore, E7386 showed synergistic antitumor activity against MMTV-Wnt1 tumor in combination with anti-PD-1 antibody. In conclusion, E7386 demonstrates clear antitumor activity via modulation of the Wnt/β-catenin signaling pathway and alteration of the tumor and immune microenvironments, and its antitumor activity can be enhanced in combination with anti-PD-1 antibody. SIGNIFICANCE: These findings demonstrate that the novel anticancer agent, E7386, modulates Wnt/β-catenin signaling, altering the tumor immune microenvironment and exhibiting synergistic antitumor activity in combination with anti-PD-1 antibody.2021年02月, Cancer research, 81(4) (4), 1052 - 1062, 英語, 国際誌研究論文(学術雑誌)
- Anticancer Research USA Inc., 2021年02月, Anticancer Research, 41(2) (2), 1021 - 1026研究論文(学術雑誌)
- INTRODUCTION: Three-dimensional (3D) laparoscopic vision can improve depth perception. However, it is a question whether 3D vision can improve motion in the depth direction. The aim of this study was to compare the impact of 3D vision on forceps motion in the depth and horizontal directions. METHODS: All data were obtained from our previous two studies, where, in total, 40 novices and 20 moderately experienced surgeons participated. A simple phantom task was performed in a training box. The participants were randomly assigned to two groups. Specifically, one group performed the task five times initially under a two-dimensional (2D) system, and the other group started under a 3D system. Both groups then performed the same task five times under the alternative system. Performances were recorded by an optical position tracker. We separately evaluated forceps motion in the x-, y-, and z-axis directions. RESULTS: Compared with the findings for 2D vision, the forceps path lengths were significantly decreased among novices and moderately experienced surgeons in almost all tasks under 3D vision. In a comparison of the path length ratio (3D/2D) in each direction, larger reduction was observed for the depth direction among novices, whereas no significant directional difference was noted among moderately experienced surgeons. CONCLUSIONS: For novices, 3D laparoscopic vision improves depth perception and may give shorter forceps movement in the depth direction even for simple tasks.2020年07月, Asian journal of endoscopic surgery, 13(3) (3), 265 - 271, 英語, 国内誌研究論文(学術雑誌)
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からのアプローチの有用性の検討シンポジウム・ワークショップパネル(公募)
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性についての検討口頭発表(一般)
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議切除困難な胃GISTに対する術前イマチニブによる補助療法の有用性に関する検討シンポジウム・ワークショップパネル(公募)
- 第96回日本胃癌学会総会, 英語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議The significance of conversion surgery following chemotherapy for clinical stage IV gastric cancer口頭発表(一般)
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議当院における進行胃癌に対するロボット支援下胃切除術の工夫口頭発表(一般)
- 第96回日本胃癌学会総会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都市, 日本国, 国内会議食道胃接合部腺癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性シンポジウム・ワークショップパネル(公募)
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議術前化学療法を施行した食道癌における腫瘍マーカーと生存転帰の検討口頭発表(一般)
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議切除不能進行胃癌に対する conversion surgery の周術期化学療法の重要性及び治療成績シンポジウム・ワークショップパネル(公募)
- 第56回制癌剤適応研究会, 日本語, 藤田医科大学医学部消化器外科学講座 ばんたね病院外科, 下呂市, 日本国, 国内会議鼠径リンパ節転移を伴う直腸・肛門管腺癌の術後成績;術前治療と選択的鼠径リンパ節郭清・直腸間膜全切除による治療戦略口頭発表(一般)
- The 19th Annual Academic Surgical Congress, 英語, Annual Academic Surgical Congress, Washington, D.C., アメリカ合衆国, 国際会議Clinical Significance of SUVmax on FDG-PET in Patients with Rectal Cancer Undergoing NACRT口頭発表(一般)
- 第207回近畿外科学会, 日本語, 関西医科大学 外科学講座, 枚方市, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性についての検討口頭発表(一般)
- 第207回近畿外科学会, 日本語, 関西医科大学 外科学講座, 枚方市, 日本国, 国内会議リンパ節郭清個数からみる MIE における上縦隔リンパ節郭清の重要性口頭発表(一般)
- 日本消化器病学会近畿支部第120回例会, 日本語, 神戸大学大学院医学研究科外科学講座 肝胆膵外科学分野, 神戸, 日本国, 国内会議当院におけるTaTME併用大腸全摘術の手術成績シンポジウム・ワークショップパネル(公募)
- 第194回兵庫県外科医会学術集会, 日本語, 兵庫県外科医会, 神戸, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同手術における結腸間膜尾側からの腹腔鏡アプローチの有用性の検討口頭発表(一般)
- 第36回日本バイオセラピィ学会学術集会総会, 日本語, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, 日本国, 国内会議深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索口頭発表(一般)
- 第36回日本バイオセラピィ学会学術集会総会, 日本語, 昭和大学医学部内科学講座腫瘍内科学部門, 東京, 日本国, 国内会議大腸癌腫瘍免疫微小環境における CD4+T 細胞に与える肥満の影響口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議安全な Collard 変法吻合を目指した変革と短期成績口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議下部進行直腸癌に対する TaTME 併用の有用性とラーニングカーブに関する検討口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議ロボット支援食道切除における上縦隔リンパ節郭清手技と短期成績口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議ロボット支援胃切除術におけるリンパ節郭清時間の learning curve口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議多発リンパ節転移を伴う進行食道癌に対する Minimally invasive esophagectomy口頭発表(一般)
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議経肛門アプローチ併用による2チーム側方郭清の手術手技と手術成績ポスター発表
- 第36回日本内視鏡外科学会総会, 日本語, 秋田大学大学院医学系研究科 腎泌尿器科学講座, 横浜, 日本国, 国内会議人間工学に基づく「鏡視下クロソイド・カーブ針」の開発口頭発表(一般)
- 第44回日本肥満学会・第41回日本肥満症治療学会学術集会, 日本語, 東北大学大学院医学系研究科 糖尿病代謝内科学分野・岩手医科大学医学部内科学講座 糖尿病・代謝・内分泌内科分野, 仙台, 日本国, 国内会議当院における腹腔鏡下スリーブ状胃切除術の短期治療成績の検討ポスター発表
- 第34回日本消化器癌発生学会総会, 日本語, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, 日本国, 国内会議深層学習アルゴリズムに基づくイメージングサイトメトリーを用いた術前化学放射線療法後の直腸癌の新規予後因子の探索シンポジウム・ワークショップパネル(公募)
- 第34回日本消化器癌発生学会総会, 日本語, 群馬大学大学院医学系研究科 総合外科学講座 肝胆膵外科学分野, 高崎, 日本国, 国内会議放射線治療において抗腫瘍効果に寄与する腫瘍内CD8+T細胞の動態シンポジウム・ワークショップパネル(公募)
- 第74回日本気管食道科学会総会ならびに学術講演会, 日本語, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, 日本国, 国内会議高齢者に対する食道切除後の腸瘻チューブ留置による栄養介入の重要性口頭発表(一般)
- 第74回日本気管食道科学会総会ならびに学術講演会, 日本語, 独立行政法人国立病院機構 九州がんセンター 消化管外科, 福岡, 日本国, 国内会議リンパ節郭清個数からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性口頭発表(一般)
- 第26回腹腔鏡内視鏡合同手術研究会, 日本語, 神戸大学 食道胃腸外科・神戸大学 国際がん医療・研究センター 消化器内科, 神戸, 日本国, 国内会議十二指腸表在性腫瘍に対する腹腔鏡内視鏡合同⼿術における結腸間膜尾側からの腹腔鏡アプローチの有⽤性の検討口頭発表(一般)
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, 英語, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, 日本国, 国際会議Clinical Significance of SUVmax on FDG-PET to Predict Treatment Response and Outcomes in Patients with Rectal Cancer Undergoing NACRTポスター発表
- IASGO-CME Advanced Post-Graduate Course in Kobe 2023, 英語, Department of Surgery, Hepato-Biliary-Pancreatic Surgery Division, Graduate School of Medicine, Kobe University, Kobe, 日本国, 国際会議The advantage of geriatric nutritional risk index as a prognostic indicator for elderly patients with early gastric cancer after noncurative endoscopic resectionポスター発表
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議The significance of geriatric nutritional risk index as a prognostic factor for early gastric cancer in elderly patients after non-curative endoscopic resection口頭発表(一般)
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議Albumin and derived neutrophil-to-lymphocyte ratio is a novel prognostic factor for patients with esophageal squamous cell carcinoma口頭発表(一般)
- The 3rd International Congress of the Asian Oncology Society (AOS2023), 英語, Department of Urology, Keio University School of Medicin, Yokohama, 日本国, 国際会議Clinical outcomes of neoadjuvant therapy followed by selective inguinal lymph node dissection and total mesorectal excision for metastasised low rectal cancer口頭発表(一般)
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議下部直腸癌に対するTaTMEの有用性とラーニングカーブシンポジウム・ワークショップパネル(公募)
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議リンパ節転移比率からみるMinimally invasive esophagectomyにおける上縦隔リンパ節郭清の重要性シンポジウム・ワークショップパネル(公募)
- 第36回近畿内視鏡外科研究会, 日本語, 近畿大学医学部外科学 下部消化管部門, 豊中, 日本国, 国内会議当院におけるロボット支援下結腸切除術の導入 10例の経験シンポジウム・ワークショップパネル(公募)
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), 英語, The Korean Gastric Cancer Association, Seoul, 大韓民国, 国際会議The advantage of geriatric nutritional risk index as a prognostic indictor for elderly patients with early gastric cancer after non-curative endoscopic resection口頭発表(一般)
- The Korea International Gastric Cancer Week 2023 (KINGCA WEEK 2023), 英語, The Korean Gastric Cancer Association, Seoul, 大韓民国, 国際会議Efficacy of 18F-fluoro-2-deoxyglucose positron emission tomography as a predictor of treatment response to neoadjuvant chemotherapy for gastric cancer口頭発表(一般)
- 第1回Hanshin-GI, 日本語, 大鵬薬品工業株式会社, 大阪/Web, 日本国, 国内会議高度進行胃癌を有するフレイル患者に対する術前化学療法の経験口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議高齢胃癌患者への内視鏡治療後非治癒切除症例における予後因子の検討口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議当院における TaTME 併用大腸全摘術の手術成績の検討口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議術中診断にて漿膜浸潤以上の深達度であった進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議当院における進行胃癌に対するロボット支援下胃切除術の短期治療成績の検討口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議短期・長期成績からみた下部直腸癌に対するTaTME の有用性について口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議高齢者に対する胸腔鏡下食道切除後の経腸栄養は sarcopenia を予防できるか?口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議鼠経転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議十二指腸浸潤を伴う胃癌に対する胃切除術の安全性の検討口頭発表(一般)
- 第78回日本消化器外科学会総会, 日本語, 弘前大学大学院医学研究科消化器外科学講座, 函館, 日本国, 国内会議ロボット支援下食道切除術の術者育成口頭発表(一般)
- 第99回大腸癌研究会学術集会, 日本語, 関西労災病院 外科, 尼崎, 日本国, 国内会議下部直腸癌に対するTaTMEの有用性とラーニングカーブ口頭発表(一般)
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議高齢者に対する腹臥位胸腔鏡下食道切除術ポスター発表
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議全周性かつ表層拡大食道癌症例の特徴と手術治療成績ポスター発表
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議食道胃接合部癌に対する腹腔鏡下経裂孔的再建における左横隔膜開放法の有用性シンポジウム・ワークショップパネル(公募)
- 第77回日本食道学会学術集会, 日本語, 近畿大学医学部 外科学教室上部消化管部門, 大阪, 日本国, 国内会議短期・長期成績からみたロボット支援食道切除術のエビデンスシンポジウム・ワークショップパネル(公募)
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, 横浜, 日本国, 国内会議Neutrophil lymphocyte ratio and histological response correlate with prognosis of gastric cancer undergoing neoadjuvant chemotherapyその他
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, 横浜, 日本国, 国内会議Safety of laparoscopic gastrectomy for advanced gastric cancer with greater than serosal invasion depthその他
- The 15th International Gastric Cancer Congress (IGCC 2023), 英語, Department of Surgery, Keio University School of Medicine, 横浜, 日本国, 国内会議The prognostic factors of early gastric cancer in elderly patients after non-curative endoscopic resectionその他
- 第193回兵庫県外科医会学術集会, 日本語, 兵庫県外科医会, 神戸, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績口頭発表(一般)
- 第66回関西胸部外科学会学術集会, 日本語, JCHO大阪病院, 大阪, 日本国, 国内会議高齢者食道癌患者に対する胸腔鏡下食道切除術口頭発表(一般)
- 第66回関西胸部外科学会学術集会, 日本語, JCHO大阪病院, 大阪, 日本国, 国内会議進行食道癌に対するロボット支援下食道切除シンポジウム・ワークショップパネル(公募)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議食道切除 ・ 胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチポスター発表
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議The mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT.口頭発表(一般)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討口頭発表(一般)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議大量の難治性乳び腹水を伴う直腸間膜リンパ管嚢腫破裂に対して手術加療を施行した 1 例その他
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議当院における TaTME 併用による大腸全摘術、 回腸嚢肛門吻合術の手術成績シンポジウム・ワークショップパネル(公募)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議高齢胃癌患者の内視鏡治療後非治癒切除症例における予後因子の検討シンポジウム・ワークショップパネル(公募)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議血行再建を伴う胸壁前有茎空腸再建術の有用性シンポジウム・ワークショップパネル(公募)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議膵臓側に位置する表在性非乳頭部十二指腸腫瘍に対する腹腔鏡内視鏡合同手術の工夫シンポジウム・ワークショップパネル(公募)
- 第48回日本外科系連合学会学術集会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国, 国内会議自律神経を意識した腹臥位胸腔鏡下食道切除術シンポジウム・ワークショップパネル(公募)
- 第45回日本癌局所療法研究会, 日本語, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, 日本国, 国内会議鼠径部転移を伴う直腸肛門腺癌に対する術前治療と選択的側方郭清の治療成績その他
- 第45回日本癌局所療法研究会, 日本語, 順天堂大学医学部・消化器外科学講座下部消化管外科, 東京, 日本国, 国内会議直腸癌の術前化学放射線療法への抵抗性における Wnt/ β -catenin シグナル活性化の重要性その他
- 第21回日本ヘルニア学会学術集会, 日本語, 大阪府済生会吹田病院へルニアセンター, 大阪, 日本国, 国内会議当科における全身合併症を伴う鼠径部ヘルニア手術の周術期管理の安全性の検討シンポジウム・ワークショップパネル(公募)
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績その他
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議当院における経肛門的アプローチ併用による大腸全摘出の手術手技その他
- 第77回手術手技研究会, 日本語, 愛知医科大学 消化器外科, 名古屋, 日本国, 国内会議当院におけるロボット支援下胃切除術のメインデバイスの変遷その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議オープンソースの物体検出アルゴリズム YOLOv3 を用いた胸腔鏡下食道亜全摘術の手術動画解析その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議下部進行直腸癌に対する術前化学放射線療法と選択的側方郭清の治療成績ポスター発表
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議食道切除後長期の腸瘻での栄養管理はサルコペニアを予防するその他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議AI 病理診断システムを用いた直腸癌の新規予後因子の探索その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議局所進行直腸癌術前療法における腫瘍内レジデントメモリー CD8+T 細胞の動態とその役割その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議Diversity からさらに未来へ~Diversity だけで十分ですか? ~その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議経肛門アプローチによる側方郭清の標準化手術手技と手術成績シンポジウム・ワークショップパネル(公募)
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議食道胃接合部癌に対する経裂孔的腹腔鏡下 y 字型食道胃管吻合の有用性その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議当院における胃・食道胃接合部腺癌に対する術前化学療法の治療成績の検討その他
- 第123回日本外科学会定期学術集会, 日本語, 東京慈恵会医科大学 外科学講座 血管外科, 東京, 日本国, 国内会議cStageIV 胃癌の conversion surgery における周術期化学療法の検討シンポジウム・ワークショップパネル(公募)
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議切除不能進行胃癌に対する姑息的胃切除術の安全性に関する検討シンポジウム・ワークショップパネル(公募)
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議高齢の胃癌患者に対する術前化学療法の安全性の検討ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議当院におけるCY1を伴う進行胃癌に対する集学的治療戦略ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議胃癌切除例におけるpoorly cohesive carcinomaの臨床病理学的特徴と予後に関する検討シンポジウム・ワークショップパネル(公募)
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議新規半消化態栄養剤を用いた胃癌術後経口栄養療法の安全性に関する検討ポスター発表
- 第95回日本胃癌学会総会, 日本語, 静岡県立静岡がんセンター内視鏡科, 札幌, 日本国, 国内会議腹腔鏡下経裂孔アプローチにおける左横隔膜開放法による下縦隔郭清・再建の安全性に関する検討ポスター発表
- 第55回制癌剤適応研究会, 日本語, 横浜市立大学 消化器・腫瘍外科学, 鎌倉, 日本国, 国内会議StageIV胃癌のconversion surgeryにおける周術期化学療法と予後の検討シンポジウム・ワークショップパネル(公募)
- The 18th Annual Academic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, アメリカ合衆国, 国内会議The mGPS is a significant oncological marker of rectal cancer patients undergoing NACRT口頭発表(一般)
- The 18th Annual Academic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, Washington, DC, アメリカ合衆国, 国内会議Risk factor for stricture after cervical triangular anastomosis in Minimally Invasive Esophagectomyその他
- 第19回日本消化管学会総会学術集会, 日本語, 日本医科大学消化器内科学・日本医科大学付属病院消化器・肝臓内科, 東京, 日本国, 国内会議胃癌・食道胃接合部癌の術前化学療法効果診断における組織学的効果判定および宿主免疫指標マーカーの有用性の検討シンポジウム・ワークショップパネル(公募)
- 第98回大腸癌研究会学術集会, 日本語, 順天堂大学大学院医学研究科・人体病理病態学, 東京, 日本国, 国内会議当院における若年者大腸癌手術症例の検討ポスター発表
- 日本消化器病学会近畿支部第118回例会, 日本語, 京都府立医科大学大学院医学研究科消化器外科学, 京都, 日本国, 国内会議食道胃接合部腺癌に対する当科の治療戦略シンポジウム・ワークショップパネル(公募)
- Asian-Pacific Congress of Robotic Laparoscopic Surgery 2022 (ACRLS2022), 英語, 藤田医科大学 国際医療センター, 名古屋/web, 日本国, 国内会議Novel “Modified Bascule method” for lymphadenectomy along the left recurrent laryngeal nerve during robot-assisted minimally invasive esophagectomy口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議難治性食道狭窄に対する腹腔鏡下食道バイパス術の工夫点と成績口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議食道癌に対する腹臥位胸腔鏡下食道切除術の短期・長期成績口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議腫瘍深達度が漿膜浸潤以上の進行胃癌に対する腹腔鏡下胃切除の安全性に関する検討口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議直腸癌に対する Abdominal robotic approach 併用による Hybrid TaTME口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議Transanal アプローチ併用側方郭清の治療成績と安全に行うための工夫口頭発表(一般)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議当科における残胃癌に対する腹腔鏡下残胃全摘術の手術成績と予後の検討シンポジウム・ワークショップパネル(公募)
- 第35回日本内視鏡外科学会総会, 日本語, 藤田医科大学 先端ロボット・内視鏡手術学講座, 名古屋, 日本国, 国内会議ロボット支援食道切除の短期成績 - 胸腔鏡手術との比較 -シンポジウム・ワークショップパネル(公募)
- 第26回日本バイオ治療法学会学術集会, 日本語, 徳島大学大学院社会産業理工学研究部生物資源産業学域, 大阪, 日本国, 国内会議AI 病理診断システムを用いた直腸癌の新規予後因子の探索口頭発表(一般)
- 第43回日本肥満学会・第40回日本肥満症治療学会学術集会, 日本語, 琉球大学大学院 医学研究科 内分泌代謝・血液・膠原病内科学講座(第二内科)・大分大学医学部 消化器・小児外科学講座, 那覇, 日本国, 国内会議COVID19 感染下における腹腔鏡下スリーブ状胃切除術の導入と短期治療成績口頭発表(一般)
- 第35回日本バイオセラピィ学会学術集会総会, 日本語, 福島県立医科大学 消化管外科学講座, 福島, 日本国, 国内会議大腸癌の腫瘍免疫微小環境における CD4 陽性T細胞に与える肥満の影響口頭発表(一般)
- 第35回日本バイオセラピィ学会学術集会総会, 日本語, 福島県立医科大学 消化管外科学講座, 福島, 日本国, 国内会議放射線治療における腫瘍内 CD8+T細胞の動態シンポジウム・ワークショップパネル(公募)
- 第84回日本臨床外科学会総会, 日本語, 久留米大学医学部外科学講座, 福岡, 日本国, 国内会議周術期チーム医療による腹臥位胸腔鏡下食道切除術シンポジウム・ワークショップパネル(公募)
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議残胃癌に対する腹腔鏡下残胃全摘術の手術成績の検討その他
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議幽門側胃切除後の残胃内容排出遅延に関する検討その他
- 第52回胃外科・術後障害研究会, 日本語, 静岡県立静岡がんセンター 胃外科, 沼津/Web, 日本国, 国内会議術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表(一般)
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, 英語, Korean Surgical Society, Seoul, 大韓民国, 国内会議Laparoscopic Endoscopic Cooperative Surgery Using Openwindow Suturing Technique for Treating Non-ampullary Superficial Duodenal Neoplasms Located on the Pancreatic Sideその他
- Annual Congress of KSS 2022 & 74th Congress of the Korean Surgical Society, 英語, Korean Surgical Society, Seoul, 大韓民国, 国内会議Comparison of Laparoscopic Gastrectomy for Gastric Cancer with 3D and 2D Monitorsシンポジウム・ワークショップパネル(公募)
- JDDW2022(第30回日本消化器関連学会週間), 日本語, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, 日本国, 国内会議食道胃接合部に近接する胃消化管間質腫瘍に対する腹腔鏡下局所切除の安全性についての検討ポスター発表
- JDDW2022(第30回日本消化器関連学会週間), 日本語, 一般社団法人 日本消化器関連学会機構(JDDW), 福岡/Web, 日本国, 国内会議オープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析ポスター発表
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表(一般)
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議cStageIV胃癌に対するconversion surgeryの手術成績と予後因子の検討シンポジウム・ワークショップパネル(公募)
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議鼠経リンパ節転移を伴う直腸癌に対する術前治療と選択的鼠経郭清の臨床的意義ポスター発表
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議術前化学療法における Alb/ dNLR の推移は食道癌の予後に関与するかポスター発表
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議直腸癌術前化学放射線療法の予後因子としての modified Glasgow Prognostic Score口頭発表(一般)
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議直腸癌術前化学放射線療法における AI を用いた腫瘍組織 CD8+T 細胞の評価方法の検討口頭発表(一般)
- 第60回日本癌治療学会学術集会, 日本語, 群馬大学大学院医学系研究科総合外科学講座 肝胆膵外科分野, 神戸/Web, 日本国, 国内会議FDG-PET/CTによる進行胃癌の病理学的病期の術前予測の有用性ポスター発表
- 第75回日本胸部外科学会定期学術集会, 日本語, 東京大学医学部附属病院 呼吸器外科, 横浜/Web, 日本国, 国内会議腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較(LAP vs HALS)口頭発表(一般)
- 日本消化器病学会近畿支部第117回例会, 日本語, 大阪公立大学大学院医学研究科肝胆膵外科学, 大阪, 日本国, 国内会議Freshman Session1 食道・胃・十二指腸その他
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京, 日本国ロボット支援食道切除術の利点と課題ポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京, 日本国胸腔鏡下食道切除症例における栄養介入としての腸瘻チューブ留置期間の検討ポスター発表
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京, 日本国腹臥位胸腔鏡下食道切除術における腹部操作アプローチの比較(LAP vs HALS)口頭発表(一般)
- 第76回日本食道学会学術集会, 日本語, 東邦大学大学院消化器外科学講座・臨床腫瘍学講座, 東京, 日本国低侵襲と合併症リスクの低減を目指した腹腔鏡下胸骨後経路作成の術後成績口頭発表(一般)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国当院における右側結腸癌に対する対腔内吻合の導入と治療成績口頭発表(一般)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国Siewert Ⅱ型接合部癌に対する経裂孔的アプローチによる下縦隔リンパ節郭清シンポジウム・ワークショップパネル(公募)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国食道切除・胸骨後再建後胃管切除に対する仰臥位胸腔鏡アプローチ口頭発表(一般)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国膵・十二指腸・横行結腸浸潤を伴う胃癌に対し術前化学療法奏効後に腹腔鏡下幽門側胃切除術を施行した一例口頭発表(一般)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国腹臥位胸腔鏡下食道切除における当科の郭清概念シンポジウム・ワークショップパネル(公募)
- 第35回近畿内視鏡外科研究会, 日本語, 兵庫医科大学消化器外科学講座上部消化管外科, 兵庫, 日本国直腸癌手術におけるTaTMEの有用性シンポジウム・ワークショップパネル(公募)
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), 英語, The Korean Gastric Cancer Association, Korea, 大韓民国Preoperative Prediction of the Pathological Stage of Advanced Gastric Cancer by 18F-fluoro-2-deoxyglucose Positron Emission Tomography口頭発表(一般)
- Korea International Gastric Cancer Week 2022 (KINGCA WEEK 2022), 英語, The Korean Gastric Cancer Association, Korea, 大韓民国Assessment of Risk Factors for Delayed Gastric Emptying After Distal Gastrectomy for Gastric Cancer口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国術前サルコペニアの層別化による短期・長期リスク評価の有用性口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国胃癌におけるFDG-PET検査によるリンパ節SUVmax値を用いたリンパ節転移診断の有用性の検討口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国術前欠損歯数が胃癌術後患者の予後に及ぼす影響についての検討口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国抗凝固療法中の患者に対する胃切除術の安全性について口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国胸腔鏡下食道切除症例における腸瘻チューブ留置による栄養介入とその意義シンポジウム・ワークショップパネル(公募)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国当院における右側結腸癌に対する体腔内吻合の手術手技と短期成績口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国cStageⅣ胃癌に対するconversion surgeryの治療成績シンポジウム・ワークショップパネル(公募)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国胃癌大弯側リンパ節郭清時に周囲リンパ節の郭清ラインとの連続性を意識した#4sb郭清手技の有用性シンポジウム・ワークショップパネル(公募)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国低肺機能患者に対する腹臥位胸腔鏡下食道切除術口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国直腸悪性腫瘍に対するHybrid手術の短期成績に関する後ろ向き研究口頭発表(一般)
- 第77回日本消化器外科学会総会, 日本語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国Siewert II型食道胃接合部癌に対する偽His角・穹窿部を付加したy字様Overlap食道胃管吻合の有用性シンポジウム・ワークショップパネル(公募)
- 第77回日本消化器外科学会総会, 英語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国Laparoscopic retrosternal route creation for gastric conduit - efficacy and outcomes 腹腔鏡による胸骨後経路作成の工夫と術後成績シンポジウム・ワークショップパネル(公募)
- 第77回日本消化器外科学会総会, 英語, 横浜市立大学消化器・腫瘍外科学, 神奈川, 日本国Development of a new method for evaluation of rectal cancer after neoadjuvant chemoradiotherapy 直腸癌術前化学放射線療法における腫瘍組織CD8+T細胞の新たな評価方法の開発シンポジウム・ワークショップパネル(公募)
- 第97回大腸癌研究会学術集会, 日本語, 埼玉医科大学総合医療センター 消化管・一般外科, 東京, 日本国閉塞性大腸癌患者に対する腹腔鏡下手術の術前自己拡張型金属ステントの有用性口頭発表(一般)
- 第44回日本癌局所療法研究会, 日本語, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, 日本国遠隔転移を有するHER2陽性進行胃癌に対しConversion Surgeryを施行し奏効を得た1例口頭発表(一般)
- 第44回日本癌局所療法研究会, 日本語, 独立行政法人 労働者健康安全機構 関西労災病院, 大阪, 日本国食道癌に対するESD後の良性狭窄に対し食道バイパス手術によりQOL向上を得られた一例口頭発表(一般)
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 徳島, 日本国術前化学療法における Alb-dNLR ratioの推移は食道癌の予後に関与するかポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 徳島, 日本国大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響ポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 徳島, 日本国cStageIV胃癌に対するconversion surgeryの予後の検討ポスター発表
- 第31回日本癌病態治療研究会, 日本語, 徳島大学消化器 移植外科学, 徳島, 日本国低侵襲治療を目指したロボット支援下胃切除術の導入と短期治療成績ポスター発表
- 第65回関西胸部外科学会学術集会, 日本語, 浜松医科大学 外科学第一講座, 静岡, 日本国食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチシンポジウム・ワークショップパネル(公募)
- AOS 2022(2nd International Congress of ASIAN ONCOLOGY SOCIETY), 英語, Asian Oncology Society, Korea, 大韓民国Thoracic cavity-to-cage ratio is a predictor of technical difficulties in minimally invasive esophagectomy口頭発表(一般)
- 第43回癌免疫外科研究会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, 日本国腫瘍抗原導入樹状細胞にiNKT細胞リガンドを付加したワクチンは、抗原特異的な抗腫瘍免疫を効果的に誘導するシンポジウム・ワークショップパネル(公募)
- 第43回癌免疫外科研究会, 日本語, 京都府立医科大学大学院医学研究科 消化器外科学, 京都, 日本国放射線治療における腫瘍内CD8+T細胞の動態シンポジウム・ワークショップパネル(公募)
- 第76回手術手技研究会, 日本語, 佐賀大学医学部 一般・消化器外科, 佐賀, 日本国腹腔鏡による胸骨後経路作成の工夫と短期成績シンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国術前化学療法におけるAlb/dNLRの推移は食道癌の予後に関与するかシンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国術前欠損歯数が胃癌予後に及ぼす影響についての検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国食道胃接合部に近接する胃GISTに対する腹腔鏡下局所切除の安全性についての検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国サルコペニアの層別化によるリスク評価の有用性ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国MIE施行症例における術前血小板リンパ球比の予後予測因子としての有用性シンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国当科における下部進行直腸癌に対する治療戦略シンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国高齢胃癌患者への内視鏡治療後非治癒切除症例における予後の検討ポスター発表
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国胃・食道胃接合部癌術前化学療法における予後予測因子の検討シンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国2チームによるTaTMEは狭骨盤や肥満による腹腔鏡下直腸癌手術の困難さを緩和するシンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国直腸癌術前化学放射線療法における腫瘍内レジデントメモリーCD8+T細胞の動態とその予後シンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国下部直腸癌に対するTaTMEと融合させたRobotic surgeryシンポジウム・ワークショップパネル(公募)
- 第122回日本外科学会定期学術集会, 日本語, 熊本大学大学院 消化器外科学, 熊本, 日本国ロボット支援食道切除におけるlearning curveと手技の工夫シンポジウム・ワークショップパネル(公募)
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国幽門側胃切除後の胃内容排出遅延の発症リスクと治療法に関する検討シンポジウム・ワークショップパネル(公募)
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国抗血栓療法中の患者に対する胃癌手術の安全性の検討ポスター発表
- 第94回日本胃癌学会総会, 日本語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国da Vinci Harmonicによるロボット支援下幽門側胃切除術の時間短縮効果と短期治療成績の検討口頭発表(一般)
- 第94回日本胃癌学会総会, 英語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国The Signicance of Surgical Intervention Following Chemotherapy for Stage IV Gastric Cancer口頭発表(一般)
- 第94回日本胃癌学会総会, 英語, 横浜市立大学附属市民総合医療センター 消化器病センター 外科, 横浜, 日本国Safety management of laparoscopic endoscopic cooperative surgery for duodenal tumorシンポジウム・ワークショップパネル(公募)
- 第14回日本ロボット外科学会学術集会, 日本語, 鹿児島大学医学部産科婦人科, Web, 日本国ロボット支援食道切除における反回神経麻痺低減の試みシンポジウム・ワークショップパネル(公募)
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web, 日本国癌幹細胞マーカーは食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるシンポジウム・ワークショップパネル(公募)
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web, 日本国大腸癌腹膜播種モデルにおける骨髄由来免疫抑制細胞の機能シンポジウム・ワークショップパネル(公募)
- 第54回制癌剤適応研究会, 日本語, 富山大学消化器・腫瘍・総合外科, Web, 日本国術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義シンポジウム・ワークショップパネル(公募)
- 17th Annual Acasemic Surgical Congress, 英語, Academic Surgical Congress · Association for Academic Surgery · Society of University Surgeons, America, アメリカ合衆国Assessing The Risk Factors for Delayed Gastric Emptying after Distal Gastrectomy for Gastric Cancer口頭発表(一般)
- 第96回大腸癌研究会, 日本語, 帝京大学医学部外科学講座, 東京, 日本国当科における経肛門アプローチ併用による側方リンパ節郭清の手術成績口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語低肺機能に対する腹臥位胸腔鏡下食道切除術口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道切除術においてenergy deviceが短期成績に及ぼす影響シンポジウム・ワークショップパネル(公募)
- 第34回日本内視鏡外科学会総会, 日本語左結腸動脈処理に着目した腹腔鏡下左側結腸癌手術口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語当院における右側結腸癌に対する体腔内吻合の導入と治療成績口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語腹腔鏡下胃切除症例における周術期抗血栓療法の安全性の検討口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語当院におけるロボット支援下幽門側胃切除術の手技定型化の確立と短期治療成績口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道手術による反回神経麻痺の軽減試み口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語直腸癌手術におけるTransanal minimally invasive ISRの有用性と課題口頭発表(一般)
- 第34回日本内視鏡外科学会総会, 日本語ロボット支援食道切除における至適剥離層シンポジウム・ワークショップパネル(公募)
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語直腸癌に対するAbdominal robotic approach併用によるHybrid TaTMEポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語大腸癌術後の早期再発のリスク因子ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語癌幹細胞マーカーは、食道扁平上皮癌に対する術前化学療法の治療効果予測に有用であるポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語腫瘍抗原導入樹状細胞にα-GalCerを付加したワクチンベクターの抗腫瘍効果ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語術前化学療法を施行した食道癌切除症例の予後を予測するバイオマーカーとしての血小板-リンパ球比の意義ポスター発表
- 第32回日本消化器癌発生学会総会/第10回国際消化器癌発生会議, 日本語当科におけるStageⅣ胃癌に対するconversion surgeryの治療成績ポスター発表
- 第30回日本コンピュータ外科学会大会, 日本語胸腔鏡下食道切除術における3D内視鏡システムは術後短期成績の改善に寄与する口頭発表(一般)
- 第30回日本コンピュータ外科学会大会, 日本語ロボット支援食道切除手術におけるlearning curve口頭発表(一般)
- 第30回日本コンピュータ外科学会大会, 日本語3D/HDおよび2D/4Kモニターが術者技術レベルごとの手術操作にもたらす影響口頭発表(一般)
- 第30回日本コンピュータ外科学会大会, 日本語3D‒CT を用いた骨盤計測と直腸癌手術時間との関連―通常の腹腔鏡下手術と Transanal Total Mesorectal Excision との違い―口頭発表(一般)
- 第72回日本気管食道科学会総会ならびに学術講演会, 日本語オープンソースの物体検出アルゴリズムYOLOv3を用いた胸腔鏡下食道亜全摘術の手術動画解析シンポジウム・ワークショップパネル(公募)
- 第72回日本気管食道科学会総会ならびに学術講演会, 日本語胸腔鏡下食道切除術における嚥下性肺炎の予防シンポジウム・ワークショップパネル(公募)
- 第51回胃外科・術後障害研究会, 日本語幽門側胃切除後の残胃内容排出遅延に関する検討シンポジウム・ワークショップパネル(公募)
- 第51回胃外科・術後障害研究会, 日本語高齢者胃癌術後の肺炎併発が長期予後へ与える影響の検討シンポジウム・ワークショップパネル(公募)
- 第22回腹腔鏡内視鏡合同研究会, 2021年11月, 日本語膵臓側に位置する表在性非乳頭部十二指腸に対する腹腔鏡内視鏡合同手術の工夫口頭発表(一般)
- 第59回日本癌治療学会学術集会, 日本語TaTMEを軸とした近未来の下部直腸癌手術シンポジウム・ワークショップパネル(公募)
- 日本外科代謝栄養学会第58回学術集会, 日本語胃癌手術症例における欠損歯が予後に及ぼす影響について口頭発表(一般)
- 日本外科代謝栄養学会第58回学術集会, 日本語食道癌患者における術前のサルコペニア予測サロゲートマーカーの開発口頭発表(一般)
- 第27回外科侵襲とサイトカイン研究会, 2021年10月, 日本語大腸癌免疫微小環境におけるCD4陽性T細胞に及ぼす肥満の影響シンポジウム・ワークショップパネル(公募)
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語ロボット支援食道切除術の短期成績と learning curve口頭発表(一般)
- 腹臥位胸腔鏡下食道切除術における上縦隔郭清手技の工夫と定型化, 2021年09月, 日本語第34回近畿内視鏡外科研究会口頭発表(一般)
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語当院における腹腔鏡下胃切除を安全に行うためのちょっとした工夫シンポジウム・ワークショップパネル(公募)
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語直腸癌手術における Robotic TaTME の可能性シンポジウム・ワークショップパネル(公募)
- 第34回近畿内視鏡外科研究会, 2021年09月, 日本語当科におけるロボット支援食道手術の課題と可能性シンポジウム・ワークショップパネル(公募)
- 第75回日本食道学会学術集会, 英語Laparoscopic retrosternal route creation; short-term postoperative outcomesポスター発表
- 第75回日本食道学会学術集会, 英語Established upper mediastinum lymphadenectomy in prone MIE improves outcomes口頭発表(一般)
- 第75回日本食道学会学術集会, 英語Validity of lymphadenectomy for No.106recL estimated by Efficacy Indexシンポジウム・ワークショップパネル(公募)
- 第30回消化器疾患病態治療研究会, 日本語直腸癌術後縫合不全は長期予後を悪化させるのか?マウスモデルと臨床研究で得られた結果からの考察口頭発表(一般)
- 第76回日本消化器外科学会総会, 日本語腹腔鏡による胸骨後経路作成の工夫と短期成績口頭発表(一般)
- 第76回日本消化器外科学会総会, 日本語至適術前治療選択のためのバイオマーカーの重要性口頭発表(一般)
- 第76回日本消化器外科学会総会, 英語Established upper mediastinum lymphadenectomy in prone MIE improves outcomesシンポジウム・ワークショップパネル(公募)
- 第76回日本消化器外科学会総会, 英語Potential of robotic surgery surpassing conventional thoracoscopic esophagectomyシンポジウム・ワークショップパネル(公募)
- 第31回日本サイトメトリー学会学術集会, 日本語大腸癌腹膜播腫モデルにおける骨髄由来免疫抑制細胞の機能口頭発表(一般)
- 第75回手術手技研究会, 日本語食道切除・胸骨後再建後胃管癌に対する仰臥位胸腔鏡アプローチシンポジウム・ワークショップパネル(公募)