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上野 嘉子医学部附属病院 放射線部講師
研究活動情報
■ 受賞- 2020年06月 日本医学放射線学会, JRS79会長賞, 膀胱癌診断におけるVI-RADSの妥当性の検討：Likert法との比較
- 2019年08月 神戸大学医学部優秀学術論文賞
- 2018年11月 Radiological Society of North America, Certificate of Merit, New and Updated Topics in Targeted Therapies for the Treatment of Advanced and Metastatic Renal Cell Carcinoma: What Radiologists Should Know (Education Exhibit)国内外の国際的学術賞
- 2017年09月 神戸大学放射線科同門会, 優秀論文賞, 癒着胎盤のMRI診断における新たなスコアリングシステムの検討； J Magn Reson Imaging. 2016;44(3):573-83.
- 2016年03月 日本腹部放射線学会, 日本腹部放射線学会バイエル奨励賞, 低線量腹部CTにおけるモデルベース逐次近似法の有用性の検討：ハイブリッド逐次近似法とFBP法との比較；欧州放射線学会２０１６
- 2015年05月 日本磁気共鳴医学会, ISMRM Travel Award, ポスター発表国内学会・会議・シンポジウム等の賞
- 2014年07月 日本磁気共鳴医学会, 日本磁気共鳴医学会バイエル学術奨励賞国際交流賞, 子宮癌の病期診断における高分解Computed DWIの有用性の検討
- 2014年03月 Korean Society of Magnetic Resonance in Medicine, Scientific poster award, Which b-Value Combination is the Best for Prostatic Cancer Detection on cDWI with High b-Value as compared with Actual DWI with High b-Value?国際学会・会議・シンポジウム等の賞
- 2013年06月 Advanced CT・MRI研究会, Advanced CT・MRI研究会 大会長賞, Scientific poster国際学会・会議・シンポジウム等の賞
- 2012年08月 アジアオセアニア放射線学会, 銅メダル賞, 前立腺癌におけるVolumetric 3D-T2-weighted MRIの有用性
- 2012年07月 神戸大学放射線科同門会, 海外学術発表奨励賞, T2WI低信号を示す前立腺病変についての教育展示；北米放射線学会 2011
- 2011年12月 Radiological Society of North America, Certificate of Merit. Education Exhibits., Dark Focus Is Not Always Evil: Characterization of the Prostate Disorders Showing Low Signal on T2-weighted MR Images.国際学会・会議・シンポジウム等の賞
- OBJECTIVES: To identify clinical and MRI features useful for diagnosing placenta accreta spectrum (PAS) in non-previa placenta and to develop diagnostic models integrating these features. METHODS: This retrospective study included 101 pregnant women with non-previa placenta who underwent MRI between January 2022 and June 2024. Nineteen were confirmed as PAS. Clinical variables and 11 MRI findings were evaluated using intraoperative or pathological results as the reference standard. Diagnostic performance was assessed using univariable analysis and repeated cross-validation of a random forest (RF) model, with ROC analysis used to assess discriminative performance. RESULTS: Hormone replacement cycle-frozen embryo transfer (HRC-FET) (sensitivity 0.89, specificity 0.63) and abnormal placental bed vascularization (sensitivity 0.63, specificity 0.90) showed the strongest univariable performance. The RF model using six variables with acceptable interobserver agreement achieved an AUC of 0.88, sensitivity 0.92, specificity 0.79, demonstrating higher discriminative performance than individual predictors. Feature importance analysis highlighted HRC-FET and abnormal placental bed vascularization as the most influential factors. CONCLUSIONS: Integrating clinical and MRI features improves PAS diagnosis in non-previa placenta. The RF model demonstrated a more balanced diagnostic profile than individual predictors in this exploratory cohort and may aid preoperative risk assessment. HRC-FET and abnormal placental bed vascularization were key contributors, supporting their relevance for risk stratification.2026年02月, European journal of radiology, 197, 112717 - 112717, 英語, 国際誌研究論文（学術雑誌）
- [18F] Fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) has traditionally been considered suboptimal for the evaluation of renal tumors due to intense physiological tracer accumulation in the urinary tract. However, incidental detection of renal masses can occur during [18F] FDG-PET examinations, and recognizing that FDG uptake varies according to tumor type can aid differential diagnosis. In patients with renal failure or those undergoing dialysis, reduced urinary excretion lowers background activity, paradoxically improving the visualization of renal tumors. Recent studies have demonstrated that high-grade and sarcomatoid renal cell carcinomas (RCCs) exhibit intense [18F] FDG uptake associated with poor prognosis, whereas benign and low-grade lesions show relatively low uptake. Although [18F] FDG-PET/CT has limited sensitivity for nodal staging, it provides high diagnostic accuracy for distant metastases, including osteolytic bone lesions. During postoperative surveillance and restaging, PET/CT contributes to early detection of recurrence and assists in therapeutic decision-making, particularly in high-risk or dialysis patients. In therapeutic monitoring, changes in metabolic parameters-such as SUVmax, metabolic tumor volume, and total lesion glycolysis-correlate with progression-free and overall survival during tyrosine kinase inhibitor or immune checkpoint inhibitor therapy. These parameters complement Response Evaluation Criteria in Solid Tumors (RECIST) and support metabolic response criteria such as PET Response Criteria in Solid Tumors (PERCIST). Moreover, novel tracers developed to overcome the intrinsic limitations of [18F] FDG, including [11C] Acetate, [18F] Fluoromisonidazole, and prostate-specific membrane antigen ligands, have shown promise in differentiating fat-poor angiomyolipoma, evaluating tumor hypoxia, and detecting FDG-negative metastases. This review discusses the current role, limitations, and future perspectives of [18F] FDG-PET in the management of renal tumors, with particular focus on RCC.2025年11月, Seminars in nuclear medicine, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare and aggressive RCC subtype defined in the 2022 WHO classification. This study aimed to describe its imaging and clinicopathological features. METHODS: A retrospective analysis was conducted on 11 patients (12 tumors) diagnosed with FH-deficient RCC between 2015 and 2024 across multiple institutions. Clinical data, imaging findings (CT, MRI, [18F] fluorodeoxyglucose (FDG) -PET/CT), and histopathological results were reviewed. RESULTS: The median age at diagnosis was 54 years (range: 35-81), with a male predominance (64%). At presentation, distant metastases were observed in 27% of patients. Based on contrast-enhanced CT findings, tumors were morphologically classified into three types: cystic-predominant (n = 5), solid-predominant (n = 4), and purely solid (n = 3). The dynamic enhancement pattern of the solid components showed progressive enhancement in 54.5% and mild corticomedullary enhancement with delayed washout in 45.5%, suggesting vascular heterogeneity. MRI showed high signal intensity of cystic components on both T1WI and T2WI, suggestive of hemorrhage. Solid components exhibited restricted diffusion on DWI in all cases, with a median ADC value of 0.88 (range: 0.77-1.18) × 10⁻³ mm²/s. On FDG-PET/CT, solid components demonstrated elevated FDG uptake (median SUVmax: 7.25; range: 6.81-10.10). Among nine cases with available follow-up data, three (33%) developed recurrence within two years after surgery. CONCLUSION: FH-deficient RCC has a high risk of metastasis and recurrence, requiring strict follow-up. Although definitive diagnosis relies on immunohistochemistry, imaging features-such as mixed cystic-solid morphology, hemorrhagic cysts, and, compared with clear cell RCC, lower enhancement, restricted diffusion, and higher FDG uptake-may serve as important diagnostic clues that facilitate accurate pathological diagnosis and management.2025年11月, Abdominal radiology (New York), 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To examine magnetic resonance imaging (MRI) features of mesonephric-like adenocarcinoma (MLA) of the uterine corpus. METHOD: MRI features of 19 patients with pathologically proven MLA of the uterine corpus were retrospectively compared with those of 95 patients with endometrial endometrioid carcinoma (EEC). RESULTS: Most patients with MLA were postmenopausal. Advanced FIGO stages were more common in the MLA than in the EEC group (63.2 % vs. 18.9 %, p < 0.001). On MRI, endophytic growth into the myometrium were more frequent in the MLA than in the EEC group (68.4 % vs. 14.7 %, p = 0.005). The median maximum tumor diameter in the MLA group (52.4 mm) tended to be larger than that in the EEC group (38.9 mm), although the difference was not statistically significant (p = 0.374). The tumor-to-muscle signal intensity ratio (SIR) on fat-suppressed gadolinium-enhanced T1-weighted gradient-echo imaging was higher in the MLA group than in the EEC group. (1.67 vs. 1.36, p = 0.002). The SIR on diffusion-weighted imaging (DWI) was comparable between the two groups (8.35 vs. 6.72, p = 0.330). The apparent diffusion coefficient value was lower in the MLA than in the EEC group (0.69 10-3 mm2/s vs. 0.76 × 10-3 mm2/s, p = 0.003). Coexisting adenomyosis was more frequent in the MLA than in the EEC group (52.6 % vs. 21.1 %, p = 0.034). The concordance rate between MRI and pathology for adenomyosis coexistence was 84.2 % for MLA, 87.4 % for EEC, and 86.8 % overall. MLA of the uterine corpus was identified in two patients, characterized by development independent of and discontinuous from the endometrium, whereas EEC in all patients demonstrated continuity with the endometrium. CONCLUSIONS: MRI of MLA of the uterine corpus typically demonstrates large, diffuse, and endophytic growth into the myometrium, with strong contrast enhancement and more restricted diffusion compared to EEC, with coexisting adenomyosis present in over 50% of patients. Therefore, postmenopausal women with adenomyosis should be carefully evaluated for MLA on MRI, particularly using DWI.2025年09月, European journal of radiology, 190, 112260 - 112260, 英語, 国際誌研究論文（学術雑誌）
- The objective of this article is to provide a comprehensive overview of the imaging characteristics of various renal cell tumors using 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET), based on the latest WHO-2022 classification. Due to the physiological accumulation of FDG in the kidneys, the clinical utility of FDG-PET in the evaluation of renal tumors has traditionally been considered limited. However, recent studies have re-evaluated its potential value. FDG-PET has demonstrated particular utility in detecting metastases and postoperative recurrence of renal cell carcinoma (RCC), as well as in identifying RCC in patients with chronic kidney failure, where FDG excretion into the urinary tract is reduced. Renal tumors are occasionally detected incidentally on FDG-PET, and FDG uptake varies depending on the tumor subtype. Therefore, a comprehensive understanding of these imaging characteristics is clinically important, as it may serve as a valuable guide for subsequent diagnostic evaluations. Furthermore, recent advancements in the development of novel PET tracers hold promise for future applications in the imaging of renal tumors. We believe that the insights gained from this study will contribute to routine diagnostic practice and the planning of future research.2025年07月, Japanese journal of radiology, 43(7) (7), 1078 - 1089, 英語, 国内誌研究論文（学術雑誌）
- 2025年06月, Japanese journal of radiology, 43(6) (6), 875 - 882, 英語, 国内誌
- PURPOSE: This study aimed to evaluate the image quality and clinical utility of a deep learning reconstruction (DLR) algorithm in ultra-high-resolution computed tomography (UHR-CT) for the diagnosis of pancreatic cystic neoplasms (PCNs). METHODS: This retrospective study included 45 patients with PCNs between March 2020 and February 2022. Contrast-enhanced UHR-CT images were obtained and reconstructed using DLR and hybrid iterative reconstruction (IR). Image noise and contrast-to-noise ratio (CNR) were measured. Two radiologists assessed the diagnostic performance of the imaging findings associated with PCNs using a 5-point Likert scale. The diagnostic performance metrics, including sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC), were calculated. Quantitative and qualitative features were compared between CT with DLR and hybrid IR. Interobserver agreement for qualitative assessments was also analyzed. RESULTS: DLR significantly reduced image noise and increased CNR compared to hybrid IR for all objects (p < 0.001). Radiologists rated DLR images as superior in overall quality, lesion delineation, and vessel conspicuity (p < 0.001). DLR produced higher AUROC values for diagnostic imaging findings (ductal communication: 0.887‒0.938 vs. 0.816‒0.827 and enhanced mural nodule: 0.843‒0.916 vs. 0.785‒0.801), although DLR did not directly improve sensitivity, specificity, and accuracy. Interobserver agreement for qualitative assessments was higher in CT with DLR (κ = 0.69‒0.82 vs. 0.57‒0.73). CONCLUSION: DLR improved image quality and diagnostic performance by effectively reducing image noise and improving lesion conspicuity in the diagnosis of PCNs on UHR-CT. The DLR demonstrated greater diagnostic confidence for the assessment of imaging findings associated with PCNs.2025年05月, Japanese journal of radiology, 英語, 国内誌研究論文（学術雑誌）
- This study aimed to evaluate the image quality of virtual monochromatic images (VMIs) reconstructed with deep learning image reconstruction (DLIR) using dual-energy CT (DECT) to diagnose pancreatic ductal adenocarcinoma (PDAC). Fifty patients with histologically confirmed PDAC who underwent multiphasic contrast-enhanced DECT between 2019 and 2022 were retrospectively analyzed. VMIs at 40-100 keV were reconstructed using hybrid iterative reconstruction (ASiR-V 30% and ASiR-V 50%) and DLIR (TFI-M) algorithms. Quantitative analyses included contrast-to-noise ratios (CNR) of the major abdominal vessels, liver, pancreas, and the PDAC. Qualitative image quality assessments included image noise, soft-tissue sharpness, vessel contrast, and PDAC conspicuity. Noise power spectrum (NPS) analysis was performed to examine the variance and spatial frequency characteristics of image noise using a phantom. TFI-M significantly improved image quality compared to ASiR-V 30% and ASiR-V 50%, especially at lower keV levels. VMIs with TFI-M showed reduced image noise and higher pancreas-to-tumor CNR at 40 keV. Qualitative evaluations confirmed DLIR's superiority in noise reduction, tissue sharpness, and vessel conspicuity, with substantial interobserver agreement (κ = 0.61-0.78). NPS analysis demonstrated effective noise reduction across spatial frequencies. DLIR significantly improved the image quality of VMIs on DECT by reducing image noise and increasing CNR, particularly at lower keV levels. These improvements may improve PDAC detection and assessment, making it a valuable tool for pancreatic cancer imaging.2025年04月, Journal of imaging informatics in medicine, 英語, 国際誌研究論文（学術雑誌）
- 2025年04月, International journal of urology : official journal of the Japanese Urological Association, 32(4) (4), 450 - 452, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本核医学会, 2025年, 核医学, 62(1) (1), 101 - 101, 日本語
- (一社)日本核医学会, 2025年, 核医学, 62(1) (1), 101 - 101, 日本語
- Cine-magnetic resonance imaging (MRI) has been used to track respiratory-induced motion of the liver and tumor and assist in the accurate delineation of tumor volume. Recent developments in compressed sensitivity encoding (SENSE; CS) have accelerated temporal resolution while maintaining contrast resolution. This study aimed to develop and assess hepatobiliary phase (HBP) cine-MRI scans using CS. Phantom was imaged using cine-MRI and signal intensity (SI) and contrast ratio (CR) measured to determine the optimal flip-angle turbo field echo (TFE) prepulse delay. We performed cine-MRI in 20 patients for one minute, with images taken every 0.5 s after administration of gadoxetic acid contrast agent. Acquired images had three different acceleration factors (SENSE, CS without denoising [CS-no], and CS with strong denoising [CS-strong]). The image quality of the HBP cine MRI was quantitatively and qualitatively analyzed. In the phantom study, a flip angle of 30 °and TFE prepulse delay of 150 ms were optimal for clinical imaging. In a clinical study, CS-strong showed the highest signal-to-noise ratio and comparable contrast ratio among the three sequences. The CS-strong group showed a significantly higher image quality (P < 0.01), except for motion smoothness (P = 0.11). CS with denoising improved the tumor-to-liver contrast and image quality in high-temporal-resolution HBP cine MRI.2024年12月, Scientific reports, 14(1) (1), 31347 - 31347, 英語, 国際誌研究論文（学術雑誌）
- The Vesical Imaging-Reporting and Data System (VI-RADS) is a standard magnetic resonance imaging (MRI) and diagnostic method for muscle-invasive bladder cancer that was published in 2018. Several studies have demonstrated that VI-RADS has high diagnostic power and reproducibility. However, reading VI-RADS requires a certain amount of expertise, and radiologists need to be aware of the various pitfalls. MRI of the bladder includes T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced imaging (DCEI). T2WI is excellent for understanding anatomy. DWI and DCEI show high contrast between the tumor and normal anatomical structures and are suitable for staging local tumors. Bladder tumors are classified into five categories according to their size and morphology and their positional relationship to the bladder wall based on the VI-RADS diagnostic criteria. If the T2WI, DWI, and DCEI categories are the same, the category is the VI-RADS category. If the categories do not match, the DWI category is the VI-RADS category. If image quality of DWI is not evaluable, the DCEI category is the final category. In many cases, DWI is dominant, but this does not mean that T2WI and DCEI can be omitted from the reading of the bladder. In this educational review, typical and atypical teaching cases are demonstrated, and how to resolve misdiagnosis and the limitations of VI-RADS are discussed. The most important aspect of VI-RADS reading is to practice multiparametric reading with a solid understanding of the characteristics and role of each sequence and an awareness of the various pitfalls.2024年12月, Abdominal radiology (New York), 49(12) (12), 4463 - 4480, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Minimal misregistration of fused PET and MRI images can be achieved with simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI). However, the acquisition of multiple MRI sequences during a single PET emission scan may impair fusion precision of each sequence. This study evaluated the diagnostic utility of time-synchronized PET/MRI using an MR active trigger and a Bayesian penalized likelihood reconstruction algorithm (BPL) to assess the locoregional extension of endometrial cancer. METHODS: Fifty-five patients with endometrial cancer who underwent pelvic 2-deoxy-2-[18F]fluoro-D-glucose PET/MRI were retrospectively evaluated. The PET emission time for the BPL reconstruction was determined by the MR active trigger of each MR sequence. The concordance rates of image interpretation with pathological T-staging, diagnostic performance for deep myometrial invasion (MI), and diagnostic confidence levels were evaluated by two readers and compared between time-synchronized, overlapping (conventional and simultaneous, but not time-synchronized), and sequential (not simultaneous) PET/MRI and MRI with diffusion-weighted imaging. Misregistration of the PET/MRI-fused images was determined by evaluating the differences in bladder dimensions. RESULTS: The T classification by time-synchronized PET/MRI was the most concordant with the pathological T classification for the two readers. Time-synchronized PET/MRI had a significantly higher diagnostic performance for deep MI and higher confidence level scores than overlapping PET/MRI for the novice reader (p = 0.033 and p = 0.038, respectively). The differences in bladder dimension on sequential PET/MRI were significantly larger than those on overlapping and time-synchronized PET/MRI (p <0.001). CONCLUSION: Time-synchronized PET/MRI is superior to conventional PET/MRI for assessing the locoregional extension of endometrial cancer.2024年08月, European journal of radiology, 179, 111678 - 111678, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To compare the image quality, inter-reader agreement, and diagnostic capability for muscle-invasive bladder cancer (MIBC) of the reconstructed images in sections orthogonal to the bladder tumor obtained by 3D Dynamic contrast-enhanced (DCE)-MRI using the Golden-angle Radial Sparse Parallel (GRASP) technique with the images directly captured using the Cartesian sampling. MATERIALS AND METHODS: This study involved 68 initial cases of bladder cancer examined with DCE-MRI (GRASP: n = 34, Cartesian: n = 34) at 3 Tesla. Four radiologists conducted qualitative evaluations (overall image quality, absence of motion artifact, absence of streak artifact, and tumor conspicuity) using a five-point Likert scale (5 = Excellent/None) and quantitative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) measurements. The areas under the receiver-operating characteristic curves (AUCs) for the Vesical Imaging-Reporting and Data System (VI-RADS) DCE score for MIBC assessment were calculated. Inter-reader agreement was also assessed. RESULTS: GRASP notably enhanced overall image quality (pooled score: GRASP 4 vs. Cartesian 3, P < 0.0001), tumor conspicuity (5 vs. 3, P < 0.05), SNR (Median 38.2 vs. 19.0, P < 0.0001), and CNR (7.9 vs. 6.0, P = 0.005), with fewer motion artifacts (5 vs. 3, P < 0.0001) and minor streak artifacts (5 vs. 5, P > 0.05). Although no significant differences were observed, the GRASP group tended to have higher AUCs for MIBC (pooled AUCs: 0.92 vs. 0.88) and showed a trend toward higher inter-reader agreement (pooled kappa-value: 0.70 vs. 0.63) compared to the Cartesian group. CONCLUSIONS: Using the GRASP for 3D DCE-MRI, the reconstructed images in sections orthogonal to the bladder tumor achieved higher image quality and improve the clinical work flow, compared to the images directly captured using the Cartesian. GRASP tended to have higher diagnostic ability for MIBC and showed a trend toward higher inter-reader agreement compared to the Cartesian.2024年08月, Japanese journal of radiology, 英語, 国内誌研究論文（学術雑誌）
- 金原出版(株), 2024年07月, 臨床放射線, 69(4) (4), 495 - 500, 日本語
- PURPOSE: To compare the utility of thin-slice fat-suppressed single-shot T2-weighted imaging (T2WI) with deep learning image reconstruction (DLIR) and conventional fast spin-echo T2WI with DLIR for evaluating pancreatic protocol. METHODS: This retrospective study included 42 patients (mean age, 70.2 years) with pancreatic cancer who underwent gadoxetic acid-enhanced MRI. Three fat-suppressed T2WI, including conventional fast-spin echo with 6 mm thickness (FSE 6 mm), single-shot fast-spin echo with 6 mm and 3 mm thickness (SSFSE 6 mm and SSFSE 3 mm), were acquired for each patient. For quantitative analysis, the SNRs of the upper abdominal organs were calculated between images with and without DLIR. The pancreas-to-lesion contrast on DLIR images was also calculated. For qualitative analysis, two abdominal radiologists independently scored the image quality on a 5-point scale in the FSE 6 mm, SSFSE 6 mm, and SSFSE 3 mm with DLIR. RESULTS: The SNRs significantly improved among the three T2-weighted images with DLIR compared to those without DLIR in all patients (P < 0.001). The pancreas-to-lesion contrast of SSFSE 3 mm was higher than those of the FSE 6 mm (P < 0.001) and tended to be higher than SSFSE 6 mm (P = 0.07). SSFSE 3 mm had the highest image qualities regarding pancreas edge sharpness, pancreatic duct clarity, and overall image quality, followed by SSFSE 6 mm and FSE 6 mm (P < 0.0001). CONCLUSION: SSFSE 3 mm with DLIR demonstrated significant improvements in SNRs of the pancreas, pancreas-to-lesion contrast, and image quality more efficiently than did SSFSE 6 mm and FSE 6 mm. Thin-slice fat-suppressed single-shot T2WI with DLIR can be easily implemented for pancreatic MR protocol.2024年06月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌研究論文（学術雑誌）
- This study investigated the utility of imaging features, such as rim enhancement on contrast-enhanced CT (CECT), in predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). This retrospective study included 158 patients (84 men; mean age, 68 years) with pathologically confirmed PDAC. The following imaging features were evaluated on CECT by two radiologists: tumor size, tumor attenuation, and the presence of rim enhancement. Cox proportional hazards analysis was performed to identify the imaging and clinicopathological features for predicting disease-free survival (DFS) and overall survival (OS). Pathological features were compared with the presence of rim enhancement. Among the 158 patients, 106 (67%) underwent curative surgery (surgery group) and 52 (33%) received conservative treatment (non-surgery group). Rim enhancement was observed more frequently in the non-surgery group than in the surgery group (44% vs. 20%; p < 0.001). Rim enhancement showed significant associations with shorter DFS and OS in the surgery group (hazard ratios (HRs), 3.03 and 2.99; p < 0.001 and p = 0.003, respectively), whereas tumor size showed significant associations with shorter OS (HR per 1 mm increase, 1.08; p < 0.001). PDACs with rim enhancement showed significant associations with higher histological tumor grades (p < 0.001). PDAC with rim enhancement on CECT could predict poorer prognosis and more aggressive tumor grades.MDPI AG, 2024年04月, Diagnostics, 14(8) (8), 782 - 782研究論文（学術雑誌）
- Uterine diverticulum is a rare congenital malformation caused by abnormal fusion of the Müllerian ducts. The diagnosis of uterine diverticulum is difficult, and it is often misdiagnosed as a Müllerian duct anomaly, degenerated uterine fibroid, or ovarian cyst. We herein report a case of uterine diverticulum mimicking an ovarian endometriotic cyst. A multiparous woman with a history of normal vaginal delivery underwent magnetic resonance imaging for investigation of lower abdominal pain and fever. A 155-mm cystic lesion was observed on the ventral side of the uterus. The content of the cyst showed high signal intensity on T1- and T2-weighted images with precipitates of low signal intensity on the dorsal side, suggesting an endometriotic cyst of the ovary. Surgical and pathological findings revealed that the cyst was pedunculated from the anterior uterine body and composed of 3 layers: CD10-positive endometrium, a smooth muscle layer, and serosa. A uterine diverticulum was definitively diagnosed.2024年03月, Radiology case reports, 19(3) (3), 934 - 938, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2024年02月, Japanese Journal of Radiology, 42(Suppl.) (Suppl.), 32 - 32, 日本語仙骨に発生した褐色脂肪腫の1例
- INTRODUCTION: Leiomyosarcoma of the inferior vena cava is associated with poor prognosis. Complete resection is the only curative treatment. We present a patient with this disease in whom cine magnetic resonance imaging was valuable in selecting the surgical strategy and mitigating invasiveness. CASE PRESENTATION: A 68-year-old woman presented with right-sided abdominal pain. Computed tomography revealed an 86 mm tumor in the right retroperitoneal space that extended into the inferior vena cava and reached superiorly to the right atrium. Percutaneous needle biopsy confirmed leiomyosarcoma. Cine magnetic resonance imaging demonstrated no adhesions between the tumor and the upper segment of inferior vena cava wall, nor with the right atrial wall, indicating resectability. Radical tumor resection was successfully performed without requiring thoracotomy. CONCLUSION: Cine magnetic resonance imaging appears to be useful in inferior vena cava leiomyosarcoma for evaluating adhesions between the tumor and vessel wall.2024年01月, IJU case reports, 7(1) (1), 30 - 33, 英語, 国際誌研究論文（学術雑誌）
- XMLink, 2024年, Korean Journal of Radiology, 25(1) (1), 24 - 24研究論文（学術雑誌）
- Abstract Objectives To ascertain the clinical behaviors of unclassified renal cell carcinoma (RCC) and its characteristic imaging findings on CT and MRI. Methods Subjects in this retrospective study were 10 patients who had received a histological diagnosis of unclassified RCC based on World Health Organization (WHO) 2022 and who had undergone CT and/or MRI prior to surgery. In terms of clinical behaviors, TNM classification, stage, postoperative recurrence, time to recurrence, and postoperative survival were evaluated. In terms of imaging findings, tumor size, growth pattern, CT density, dynamic contrast-enhancement (DCE) pattern, internal appearance, presence of a pseudocapsule, and signal intensity on MRI were evaluated. We compared clinical behaviors and imaging findings, and investigated associations between them. Results One patient could not be followed-up due to death from other causes. Postoperative recurrence was observed in 4 patients, all of whom had Stage 3 RCC. In the remaining 5 patients without recurrence, all 5 patients showed Stage 2 or below. On imaging, unclassified RCC tended to be large (58.7 mm) and solid (100%), and heterogeneous interiors (80%), cystic degeneration (80%) and high intensity on diffusion-weighted imaging (DWI) (71.4%) were common. Comparing patients with and without recurrence, the following findings tended to differ between recurrence and recurrence-free groups: tumor size (73.4 ± 33.9 mm vs. 50.2 ± 33.9 mm, P = 0.286), growth pattern (invasive: 100% vs. 0%, expansive: 0% vs. 100%, P = 0.008 each), DCE pattern (progressive enhancement pattern, 66.7% vs. 0%, washout pattern, 0% vs. 66.7%, P = 0.135 each) and presence of a pseudocapsule (25% vs. 80%, P = 0.167). Conclusion The clinical behavior of unclassified RCC varies widely. Although imaging findings are also variable, findings of large, heterogeneous tumors with cystic degeneration and high intensity on DWI were common. Several imaging findings such as large size, invasive growth, progressive enhancement pattern and no pseudocapsule may enable prediction of prognosis in unclassified RCC.Springer Science and Business Media LLC, 2023年08月, Japanese Journal of Radiology研究論文（学術雑誌）
- (一社)日本磁気共鳴医学会, 2023年05月, 日本磁気共鳴医学会雑誌, 43(2) (2), 76 - 78, 日本語
- To assess the value of nonenhancing capsule by adding to enhancing capsule in gadoxetic acid-enhanced MRI (EOB-MRI) in comparison with contrast-enhanced CT (CE-CT) for diagnosing histological capsule in hepatocellular carcinoma (HCC). One-hundred fifty-one patients with HCC who underwent both CE-CT and EOB-MRI were retrospectively reviewed. Liver Imaging-Reporting and Data System (LI-RADS) v2018 imaging features, including enhancing and nonenhancing capsule were evaluated by two readers in CE-CT and EOB-MRI. Frequencies of each imaging feature were compared between CE-CT and EOB-MRI. The area under the receiver operating characteristic (AUC) curve for the diagnosis of histological capsule was compared across the following three imaging criteria: (1) enhancing capsule in CE-CT, (2) enhancing capsule in EOB-MRI, and (3) enhancing/nonenhancing capsule in EOB-MRI. Enhancing capsule in EOB-MRI was significantly less frequently depicted than that in CE-CT (p < 0.001 and = 0.016 for reader 1 and 2). Enhancing/nonenhancing capsule in EOB-MRI achieved a similar frequency of enhancing in CE-CT (p = 0.590 and 0.465 for reader 1 and 2). Adding nonenhancing capsule to enhancing capsule in EOB-MRI significantly increased AUCs (p < 0.001 for both readers) and achieved similar AUCs compared with enhancing capsule in CE-CT (p = 0.470 and 0.666 for reader 1 and 2). Adding nonenhancing capsule to the definition of capsule appearance can improve the diagnosis of capsule in EOB-MRI for the diagnosis of histological capsule in HCC and decrease discordance of capsule appearance between EOB-MRI and CE-CT.2023年04月, Scientific reports, 13(1) (1), 6113 - 6113, 英語, 国際誌研究論文（学術雑誌）
- The incidence of hepatocellular carcinoma (HCC) is still on the rise in North America and Europe and is the second leading cause of cancer-related mortality. The treatment of HCC varies, with surgery and locoregional therapy (LRT) such as radiofrequency ablation and transcatheter arterial chemoembolization, and radiation therapy being the primary treatment. Currently, systemic therapy with molecular-targeted agents and immune checkpoint inhibitors (ICIs) is becoming a major treatment option for the unresectable HCC. As the HCC after LRT or systemic therapy often remains unchanged in size and shows loss of contrast effect in contrast-enhanced CT or MRI, the response evaluation criteria in solid tumors (RECIST) and World Health Organization criteria, which are usually used to evaluate the treatment response of solid tumors, are not appropriate for HCC. The modified RECIST (mRECIST) and the European Association for the Study of the Liver (EASL) criteria were developed for HCC, with a focus on viable lesions. The latest 2018 edition of the Liver Imaging Reporting and Data System (LI-RADS) also includes a section on the evaluation of treatment response. The cancer microenvironment influences the therapeutic efficacy of ICIs. Several studies have examined the utility of gadoxetic acid-enhanced MRI for predicting the pathological and molecular genetic patterns of HCC. In the future, it may be possible to stratify prognosis and predict treatment response prior to systemic therapy by using pre-treatment imaging findings.2023年04月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 22(2) (2), 209 - 220, 英語, 国内誌研究論文（学術雑誌）
- PURPOSE: To investigate the added value of contrast enhancement boost (CE-boost) images in multiphasic contrast-enhanced CT (CE-CT) for diagnosing small (<20 mm) hypervascular hepatocellular carcinoma (HCC). MATERIALS AND METHODS: This retrospective study included 69 patients (age, 74 ± 8 years; 52 men) with 70 hypervascular HCCs (<20 mm) who underwent multiphasic CE-CT (pre-contrast, late arterial phase [LAP], portal venous phase [PVP], and equilibrium phase). Two types of CE-boost images were generated by subtracting PVP from LAP (LA-PV) images and LAP from PVP (PV-LA) images to enhance the contrast effect of hepatic arterial and portal venous perfusion more selectively. Tumor-to-liver contrast-to-noise ratios (CNRs) in CE-boost images were compared with those in CE-CT images using the Wilcoxon signed-rank test. Two independent readers reviewed the imaging datasets: CE-CT alone and CE-CT with CE-boost images. The diagnostic performance of each dataset was compared using jackknife alternative free-response receiver operating characteristics (JAFROC-1). RESULTS: The tumor-to-liver CNRs in the LA-PV (6.4 ± 3.0) and PV-LA (-3.3 ± 2.1) images were greater than those in the LAP (3.2 ± 1.7) and PVP images (-1.1 ± 1.4) (p <.001 for both). The reader-averaged figures of merit were 0.751 for CE-CT alone and 0.807 for CE-CT with CE-boost images (p <.001). Sensitivities increased by adding CE-boost images for both readers (p <.001 and = 0.03), while positive predictive values were equivalent (p >.99). CONCLUSION: Adding CE-boost images to multiphasic CE-CT can improve the diagnostic accuracy and sensitivity for small hypervascular HCC by increasing the tumor-to-liver CNR.2023年03月, European journal of radiology, 160, 110696 - 110696, 英語, 国際誌研究論文（学術雑誌）
- Congenital cytomegalovirus infection (cCMV) can cause fetal growth restriction (FGR) and severe sequelae in affected infants. Clinicians generally suspect cCMV based on multiple ultrasound (US) findings associated with cCMV. However, no studies have assessed the diagnostic accuracy of fetal US for cCMV-associated abnormalities in FGR. Eight FGR and 10 non-FGR fetuses prenatally diagnosed with cCMV were examined by undergoing periodic detailed US examinations, as well as postnatal physical and imaging examinations. The diagnostic accuracy of prenatal US for cCMV-associated abnormalities was compared between FGR and non-FGR fetuses with cCMV. The diagnostic sensitivity rates of fetal US for cCMV-related abnormalities in FGR vs. non-FGR fetuses were as follows: ventriculomegaly, 66.7% vs. 88.9%; intracranial calcification, 20.0% vs. 20.0%; cysts and pseudocysts in the brain, 0% vs. 0%; ascites, 100.0% vs. 100.0%; hepatomegaly, 40.0% vs. 100.0%; splenomegaly, 0% vs. 0%. The diagnostic sensitivity of fetal US for hepatomegaly and ventriculomegaly in FGR fetuses with cCMV was lower than that in non-FGR fetuses with cCMV. The prevalence of severe long-term sequelae (e.g., bilateral hearing impairment, epilepsy, cerebral palsy, and severe developmental delay) in the CMV-infected fetuses with FGR was higher, albeit non-significantly. Clinicians should keep in mind the possibility of overlooking the symptoms of cCMV in assessing fetuses with FGR.2023年01月, Diagnostics (Basel, Switzerland), 13(2) (2), 英語, 国際誌研究論文（学術雑誌）
- Springer Science and Business Media LLC, 2022年09月, European Radiology, 33(2) (2), 1388 - 1399研究論文（学術雑誌）
- Viral hepatitis was previously the most common cause of chronic liver disease. However, in recent years, nonalcoholic fatty liver disease (NAFLD) cases have been increasing, especially in developed countries. NAFLD is histologically characterized by fat, fibrosis, and inflammation in the liver, eventually leading to cirrhosis and hepatocellular carcinoma. Although biopsy is the gold standard for the assessment of the liver parenchyma, quantitative evaluation methods, such as ultrasound, CT, and MRI, have been reported to have good diagnostic performances. The quantification of liver fat, fibrosis, and inflammation is expected to be clinically useful in terms of the prognosis, early intervention, and treatment response for the management of NAFLD. The aim of this review was to discuss the basics and prospects of MRI-based tissue quantifications of the liver, mainly focusing on proton density fat fraction for the quantification of fat deposition, MR elastography for the quantification of fibrosis, and multifrequency MR elastography for the evaluation of inflammation.2022年05月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 英語, 国内誌研究論文（学術雑誌）
- ABSTRACT: A 52-year-old woman with a rapidly growing uterine tumor suspected of uterine sarcoma underwent 18F-FDG PET/MRI, revealing a myometrial mass and an endometrial lesion, suggesting dual primary neoplasms. Based on the PET/MRI findings, we changed the intraoperative procedure to determine the necessity of pelvic lymphadenectomy. PET/MRI was useful in diagnosing and differentiating between 2 malignant neoplasms in the uterus compared with PET/CT, due to MRI's high contrast resolution and precise fusion due to the simultaneous acquisition.2022年03月, Clinical nuclear medicine, 47(6) (6), e452-e454, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: In renal cell carcinoma with inferior vena cava (IVC) thrombus, adhesion or invasion to the IVC wall often increases the level of surgical difficulty and even necessitates resection of the IVC. It is generally difficult to perform an accurate preoperative assessment by the standard imaging modalities of contrast-enhanced computed tomography and standard magnetic resonance imaging (MRI). Cine MR imaging is an MRI sequence that captures motion to produce detailed information on both anatomy and dynamic motion. The present study aimed to evaluate the accuracy of preoperative cine MRI for determining IVC wall resection, with the validation of the imaging findings based on the intraoperative findings. METHODS: Fifteen patients who underwent radical nephrectomy and tumor thrombectomy between May 2018 and April 2020 met the inclusion criteria. The primary outcome of interest was the need for IVC resection because of adhesion or invasion of a venous tumor thrombus. Cine MRI evaluated the blood flow between the tumor thrombus and the IVC wall, and the presence of tumor thrombus mobility under free respiration. Sensitivity and specificity were calculated for preoperative cine MRI for IVC wall resection. Fisher's exact test was used to determine the association between intraoperative IVC wall resection and the cine MRI findings. Furthermore, receiver operating characteristic curves and the area under the curve were used to compare the accuracy of conventional MRI and cine MRI. RESULTS: Eight (53.3％) of the patients underwent IVC resection. We found that the absence of dynamic blood flow and tumor thrombus mobility on cine MRI could reliably predict IVC resection with 100％ (95％-CI: 51.8-100) sensitivity and 85.7％(95％-CI:42.1-1.00) specificity. The area under the curve of the receiver operating characteristic curve was 0.821 for conventional MRI and 0.929 for cine MRI. CONCLUSION: In the preoperative setting, cine MRI could be a helpful examination modality to predict the need for IVC wall resection in patients with renal cell carcinoma with venous tumor thrombus.2022年03月, Journal of vascular surgery. Venous and lymphatic disorders, 10(4) (4), 908 - 915, 英語, 国際誌研究論文（学術雑誌）
- (株)Gakken, 2022年03月, 画像診断, 42(4) (4), S106 - S119, 日本語
- (株)Gakken, 2022年03月, 画像診断, 42(4) (4), S184 - S195, 日本語
- Background: Prostate apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging have been used for evaluating prostate cancer (PCa) aggressiveness. However, the way of measuring ADC values has varied depending on the study. Purpose: To investigate inter- and intra-reader variability and diagnostic performance of three kinds of shaped 2D regions of interests (ROIs) for tumor ADC measurements in PCa. Material and Methods: Seventy-four patients with PCa undergoing 3-T MRI before surgery were included. Histologic findings from radical prostatectomy specimens were reviewed to define each patient's dominant tumor. Three readers independently measured the tumor ADCs using three different ROI methods: freehand, large-circle, and small-circles ROIs. Readers repeated measurements after 3 weeks. Bland-Altman analysis was performed to evaluate the inter- and intra-reader variability. Receiver Operating Characteristic analysis was used for assessment of tumor aggressiveness for PCa. Results: For intra-reader and inter-reader variability, the mean coefficient of repeatability for freehand ROIs, large-circle ROIs, and small-circles ROIs were as follows: 13.7%, 12.4%, and 11.5%; 9.4%, 9.7%, and 9.5%. For differentiating Gleason score (GS) = 3 + 3 from GS ≥ 3 + 4 tumors, the area under the curves were 0.90 for freehand ROIs, 0.89 for large-circle ROIs, and 0.94 small-circles ROIs (p = 0.31). Conclusion: The variations in ROI method did not have a major influence on intra-reader or inter-reader reproducibility or diagnostic performance for prostate ADC measurements.2022年03月, Acta radiologica open, 11(3) (3), 20584601221086500 - 20584601221086500, 英語, 国際誌研究論文（学術雑誌）
- OBJECTIVE: To investigate the diagnostic performance of the extracellular volume (ECV) fraction in multiphasic contrast-enhanced computed tomography (CE-CT) for estimating histologic pancreatic fibrosis and predicting postoperative pancreatic fistula (POPF). METHODS: Eighty-five patients (49 men; mean age, 69 years) who underwent multiphasic CE-CT followed by pancreaticoduodenectomy with pancreaticojejunal anastomosis between January 2012 and December 2018 were retrospectively included. The ECV fraction was calculated from absolute enhancements of the pancreas and aorta between the precontrast and equilibrium-phase images, followed by comparisons among histologic pancreatic fibrosis grades (F0‒F3). The diagnostic performance of the ECV fraction in advanced fibrosis (F2‒F3) was evaluated using receiver operating characteristic curve analysis. Multivariate logistic regression analysis was used to evaluate the associations of the risk of POPF development with patient characteristics, histologic findings, and CT imaging parameters. RESULTS: The mean ECV fraction of the pancreas was 34.4% ± 9.5, with an excellent intrareader agreement of 0.811 and a moderate positive correlation with pancreatic fibrosis (r = 0.476; p < 0.001). The mean ECV fraction in advanced fibrosis was significantly higher than that in no/mild fibrosis (44.4% ± 10.8 vs. 31.7% ± 6.7; p < 0.001), and the area under the receiver operating characteristic curve for the diagnosis of advanced fibrosis was 0.837. Twenty-two patients (25.9%) developed clinically relevant POPF. Multivariate logistic regression analysis demonstrated that the ECV fraction was a significant predictor of POPF. CONCLUSIONS: The ECV fraction can offer quantitative information for assessing pancreatic fibrosis and POPF after pancreaticojejunal anastomosis. KEY POINTS: • There was a moderate positive correlation of the extracellular volume (ECV) fraction of the pancreas in contrast-enhanced CT with the histologic grade of pancreatic fibrosis (r = 0.476; p < 0.001). • The ECV fraction was higher in advanced fibrosis (F2‒F3) than in no/mild fibrosis (F0‒F1) (p < 0.001), with an AUC of 0.837 for detecting advanced fibrosis. • The ECV fraction was an independent risk factor for predicting subclinical (odds ratio, 0.81) and clinical (odds ratio, 0.80) postoperative pancreatic fistula.2022年03月, European radiology, 32(3) (3), 1770 - 1780, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to investigate the characteristics of magnetic resonance imaging (MRI) findings in pure prostatic ductal adenocarcinoma. METHODS: From January 2009 to February 2020, seven patients who were diagnosed with pure prostatic ductal adenocarcinoma and had a referable preoperative MRI scan were included in the study. We evaluated the following MRI findings for each tumor: size, location, presence of multi-cystic component, and apparent diffusion coefficient (ADC) value. RESULTS: The median maximum diameter of the tumors was 22 mm (range 19-70 mm). Regarding transverse distribution, five tumors were located in the periurethral area and two were located peripherally apart from the urethra. Two of the seven tumors had cystic components. The median ADC value of the tumors was 0.754 × 10-3 mm2/s (range 0.570-0.963 × 10-3 mm2/s). Based on the transverse distribution and components of the tumors on MRI, ductal adenocarcinomas were classified into three types: type I as a non-cystic tumor located peripherally apart from the urethra (29%, two cases); type II as a non-cystic tumor located in the periurethral area (43%, three cases); and type III as a tumor with a multi-cystic component (29%, two cases). CONCLUSION: The non-cystic mass with periurethral distribution (type II) and multi-cystic mass (type III) may be characteristic features that differentiate pure ductal adenocarcinoma from ordinary acinar adenocarcinoma on MRI.2022年02月, Abdominal radiology (New York), 47(6) (6), 1929 - 1938, 英語, 国際誌研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2022年02月, Japanese Journal of Radiology, 40(Suppl.) (Suppl.), 39 - 39, 日本語123I-MIBGシンチグラフィで腎に異常集積を認めた腎動脈解離の1例
- BACKGROUND: Gadoxetic acid-enhanced magnetic resonance imaging (MRI) is useful in detecting liver metastases from pancreatic ductal adenocarcinoma (PDAC). However, the long examination time limits its utility in the initial workup of patients with PDAC. PURPOSE: To evaluate the incremental value of an abbreviated gadoxetic acid-enhanced MRI for the detection of liver metastases in patients with PDAC. STUDY TYPE: Retrospective. POPULATION: Patients (N = 130) with potentially resectable PDAC (women, 58 [44.6%]). FIELD STRENGTH/SEQUENCE: 1.5 T and 3 T; gradient dual-echo T1-weighted (in-phase and opposed-phase), fat-suppressed fast spin-echo T2-weighted, single-shot echo-planar diffusion-weighted, and three-dimensional fat-suppressed T1-weighted gradient-echo dynamic contrast-enhanced and hepatobiliary phase sequences, as well as contrast-enhanced computed tomography (CECT). ASSESSMENT: Three radiologists independently reviewed three different image sets to detect liver metastases: set 1, CECT alone; set 2, CECT and abbreviated MRI comprising fat-suppressed T2-weighted, diffusion-weighted, and hepatobiliary phase images; and set 3, CECT and standard gadoxetic acid-enhanced MRI. STATISTICAL TESTS: Figure of merit (FOM) was compared using the jackknife alternative free-response receiver operating characteristics, and other per-lesion and per-patient diagnostic parameters for each image set were compared using McNemar's and Fisher's test. P < 0.05 was considered statistically significant. RESULTS: A total of 43 liver metastases were identified in 13 patients. Reader-averaged FOM to detect liver metastases were significantly higher for sets 2 (0.884) and 3 (0.886) than for set 1 (0.609), while they were comparable between sets 2 and 3 (P = 0.96). The mean per-patient sensitivities, negative predictive values, and accuracies were significantly higher for sets 2 and 3 than for set 1, while those between sets 2 and 3 were not significantly different (not applicable, P > 0.99, and P > 0.99, respectively). DATA CONCLUSION: Gadoxetic acid-enhanced MRI combined with CECT had higher diagnostic performance than CECT alone for the detection of liver metastases in patients with PDAC. The incremental values were comparable for the abbreviated MRI and standard MRI. LEVEL OF EVIDENCE: 3 TECHNICAL EFFICACY: Stage 2.2022年01月, Journal of magnetic resonance imaging : JMRI, 56(3) (3), 725 - 736, 英語, 国際誌研究論文（学術雑誌）
- (一社)日本泌尿器科学会総会事務局, 2021年12月, 日本泌尿器科学会総会, 109回, PP30 - 07, 日本語前立腺生検における狙撃生検及び系統的生検の有用性について 導管内癌(IDC-P)に狙撃生検は可能か?
- (一社)西日本泌尿器科学会, 2021年11月, 西日本泌尿器科学会総会抄録集, 73回, 166 - 166, 英語術前cine MRIによる腎癌血栓の下大静脈壁への癒着評価の有効性(The efficacy of pre-operative cine MRI to evaluate the adhesion of renal cancer thrombus to the wall of inferior vena cava)
- 2021年11月, Japanese Archive of cases conference of clinical nuclear medicine, 3, 9 - 17
- Radiotherapy (RT) is used to manage cervical cancer, and pelvic insufficiency fracture (PIF) is known as a late complication of RT. The present study identified risk factors for PIF after radiotherapy for cervical cancer, and investigated its incidence rate. It also considered the usefulness of positron emission tomography/magnetic resonance imaging (PET/MRI) in PIF diagnosis. A total of 149 patients with cervical cancer who received definitive or adjuvant RT with/without concurrent chemotherapy between January 2013 and December 2018 were investigated in the present study and followed up for more than one month after RT at Kobe University Hospital. The median follow-up period was 32 months (range, 1-87 months), and the median age of all patients was 66 years (age range, 34-90 years). Computed tomography (CT), MRI, PET/CT or PET/MRI were used for image examination. Among the 149 patients, 31 (20.8%) developed PIF. The median age of these patients was 69 years (age range, 44-87 years). Univariate analysis using the log-rank test demonstrated that age (≥60 years) was significantly associated with PIF. The median maximum standardized uptake value of PIF sites on PET/CT was 4.32 (range, 3.04-4.81), and that on PET/MRI was 3.97 (range, 1.21-5.96) (P=0.162). Notably, the detection time of PIF by PET/MRI was significantly earlier compared with PET/CT (P<0.05). The incidence of PIF after RT for cervical cancer was 20.8%, and age was significantly associated with risk factors for such fractures. Taken together, these results suggest that PET/MRI, which offers the advantage of decreased radiation exposure to the patient, is useful for diagnosing PIF and can detect it earlier than PET/CT imaging.2021年11月, Oncology letters, 22(5) (5), 776 - 776, 英語, 国際誌研究論文（学術雑誌）
- For assessing a cancer treatment, and for detecting and characterizing cancer, Diffusion-weighted imaging (DWI) is commonly used. The key in DWI's use extracranially has been due to the emergence of of high-gradient amplitude and multichannel coils, parallelimaging, and echo-planar imaging. The benefit has been fewer motion artefacts and high-quality prostate images.Recently, new techniques have been developed to improve the signal-to-noise ratio of DWI with fewer artefacts, allowing an increase in spatial resolution. For apparent diffusion coefficient quantification, non-Gaussian diffusion models have been proposed as additional tools for prostate cancer detection and evaluation of its aggressiveness. More recently, radiomics and machine learning for prostate magnetic resonance imaging have emerged as novel techniques for the non-invasive characterisation of prostate cancer. This review presents recent developments in prostate DWI and discusses its potential use in clinical practice.2021年09月, The British journal of radiology, 95(1131) (1131), 20210653 - 20210653, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: This study aimed to examine MRI features and staging of neuroendocrine carcinoma (NEC) of the endometrium and evaluate survival. METHODS: Clinical data, pathological, and preoperative pelvic MRI findings in 22 patients with histologically surgery-proven endometrial NEC were retrospectively reviewed. Tumors were pure NEC (n = 10) or mixed histotype (n = 12), with 13 large and nine small cell type. RESULTS: International Federation of Gynecology and Obstetrics (FIGO) staging was I, II, III, and IV in 6, 2, 12, and 2 patients, respectively. In 13 (76.4%) of 17 patients with pathological deep myometrial invasion, MRI showed abnormal diffusely infiltrative high T2 signal intensity throughout the myometrium with loss of normal uterine architecture. All tumors had restricted diffusion (apparent diffusion coefficient map low signal intensity, diffusion weighted imaging high signal intensity). Accuracy of T staging by MRI for all cases was 81.8%, with reference to pathology staging, while patient-based sensitivity, specificity, and accuracy for detecting metastatic pelvic lymph nodes was 60.0%, 100%, and 77.8%, respectively. Two intrapelvic peritoneal dissemination cases were detected by MRI. During follow-up (mean 30.4, range 3.3-138.4 months), 16 patients (72.7%) experienced recurrence and 12 (54.5%) died of disease. Two-year disease-free and overall survival rates for FIGO I, II, III, and IV were 66.7% and 83.3%, 50% and 100%, 10% and 33.3%, and 0% and 0%, respectively. CONCLUSION: Abnormal diffusely infiltrative high T2 signal intensity throughout the myometrium with normal uterine architecture loss and obvious restricted diffusion throughout the tumor are suggestive features of endometrial NEC. Pelvic MRI is reliable for intrapelvic staging of affected patients.2021年09月, Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 20(3) (3), 236 - 244, 英語, 国内誌研究論文（学術雑誌）
- OBJECTIVES: To evaluate the interreader agreement and diagnostic performance of the Prostate Imaging Reporting and Data System (PI-RADS) v2.1, in comparison with v2. METHODS: Institutional review board approval was obtained for this retrospective study. Seventy-seven consecutive patients who underwent a prostate multiparametric magnetic resonance imaging at 3.0 T before radical prostatectomy were included. Four radiologists (two experienced uroradiologists and two inexperienced radiologists) independently scored eight regions [six peripheral zones (PZ) and two transition zones (TZ)] using v2.1 and v2. Interreader agreement was assessed using κ statistics. To evaluate diagnostic performance for clinically significant prostate cancer (csPC), area under the curve (AUC) was estimated. RESULTS: 228 regions were pathologically diagnosed as positive for csPC. With a cutoff ≥3, the agreement among all readers was better with v2.1 than v2 in TZ, PZ, or both zones combined (κ-value: TZ, 0.509 vs 0.414; PZ, 0.686 vs 0.568; both zones combined, 0.644 vs 0.531). With a cutoff ≥4, the agreement among all readers was also better with v2.1 than v2 in the PZ or both zones combined (κ-value: PZ, 0.761 vs 0.701; both zones combined, 0.756 vs 0.709). For all readers, AUC with v2.1 was higher than with v2 (TZ, 0.826-0.907 vs 0.788-0.856; PZ, 0.857-0.919 vs 0.853-0.902). CONCLUSIONS: Our study suggests that the PI-RADS v2.1 could improve the interreader agreement and might contribute to improved diagnostic performance compared with v2. ADVANCES IN KNOWLEDGE: PI-RADS v2.1 has a potential to improve interreader variability and diagnostic performance among radiologists with different levels of expertise.2021年04月, The British journal of radiology, 95(1131) (1131), 20201434 - 20201434, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age. METHODS: Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland-Altman plots were created for the repeatability assessment. Kruskal-Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex. RESULTS: The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0-9 years and 10-20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0-9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p<0.001). In women, the SUVmax of the face (2.31±0.71) of ≥70-year-olds was significantly lower than that of 30-39-year-olds (3.83±0.82) (p<0.05). CONCLUSION: PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.2021年, PloS one, 16(3) (3), e0249304, 英語, 国際誌研究論文（学術雑誌）
- PURPOSE: Hierarchical clustering (HC), an unsupervised machine learning (ML) technique, was applied to multi-parametric MR (mp-MR) for prostate cancer (PCa). The aim of this study is to demonstrate HC can diagnose PCa in a straightforward interpretable way, in contrast to deep learning (DL) techniques. METHODS: HC was constructed using mp-MR including intravoxel incoherent motion, diffusion kurtosis imaging, and dynamic contrast-enhanced MRI from 40 tumor and normal tissues in peripheral zone (PZ) and 23 tumor and normal tissues in transition zone (TZ). HC model was optimized by assessing the combinations of several dissimilarity and linkage methods. Goodness of HC model was validated by internal methods. RESULTS: Accuracy for differentiating tumor and normal tissue by optimal HC model was 96.3% in PZ and 97.8% in TZ, comparable to current clinical standards. Relationship between input (DWI and permeability parameters) and output (tumor and normal tissue cluster) was shown by heat maps, consistent with literature. CONCLUSION: HC can accurately differentiate PCa and normal tissue, comparable to state-of-the-art diffusion based parameters. Contrary to DL techniques, HC is an operator-independent ML technique producing results that can be interpreted such that the results can be knowledgeably judged.2020年12月, Magnetic resonance imaging, 74, 90 - 95, 英語, 国際誌研究論文（学術雑誌）
- To date, there is little consensus on the role of pelvic imaging in assessing local disease extent during initial staging in patients with endometrial carcinoma, with practices differing widely across centers. However, when pretreatment assessment of local tumor extent is indicated, MRI is the preferred imaging modality. Preoperative imaging of endometrial carcinoma can define the extent of disease and indicate the need for subspecialist referral in the presence of deep myometrial invasion, cervical extension, or suspected lymphadenopathy. If distant metastatic disease is clinically suspected, preoperative assessment with cross-sectional imaging or PET/CT may be performed. However, most patients with low-grade disease are at low risk of lymph node and distant metastases. Thus, this group may not require a routine pretreatment evaluation for distant metastases. Recurrence rates in patients with endometrial carcinoma are infrequent. Therefore, radiologic evaluation is typically used only to investigate suspicion of recurrent disease due to symptoms or physical examination and not for routine surveillance after treatment. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.2020年11月, Journal of the American College of Radiology : JACR, 17(11S) (11S), S472-S486 - 486, 英語, 国際誌[招待有り]研究論文（学術雑誌）
- (一社)日本核医学会, 2020年10月, 核医学, 57(Suppl.) (Suppl.), S155 - S155, 英語肺病変に関するPET/MRIにおけるZero-TE法の診断能について
- PURPOSE: Accurate prediction of post-hepatectomy liver failure (PHLF) is important in advanced hepatocellular carcinoma (HCC). We aimed to retrospectively evaluate the utility of gadoxetic acid-enhanced MRI for predicting PHLF in patients who underwent anatomic hepatectomy for HCC with portal vein invasion. METHODS: Forty-one patients (32 men, 9 women) were included. Hepatobiliary-phase MR images were acquired 20 min after injection of gadoxetic acid using a 3D fat-suppressed T1-weighted spoiled gradient-echo sequence. Liver-spleen ratio (LSR), remnant hepatocellular uptake index (rHUI), and HUI were calculated. The severity of PHLF was defined according to the International Study Group of Liver Surgery. Differences in LSR between the resected liver and the remnant liver, and HUI and rHUI/HUI between no/mild and severe PHLF were compared using the Wilcoxon signed-rank test and Wilcoxon rank-sum test, respectively. Univariate and multivariate logistic regression analyses were performed to identify predictors of severe PHLF. Areas under the receiver operating characteristic curves (AUCs) of rHUI and rHUI/HUI were calculated for predicting severe PHLF. RESULTS: Nine patients developed severe PHLF. LSR of the remnant liver was significantly higher than that of the resected liver (P < 0.001). Severe PHLF demonstrated significantly lower rHUI (P < 0.001) and rHUI/HUI (P < 0.001) compared with no/mild PHLF. Multivariate logistic regression analysis showed that decreased rHUI (P = 0.012, AUC=0.885) and rHUI/HUI (P = 0.002, AUC=0.852) were independent predictors of severe PHLF. CONCLUSION: Gadoxetic acid-enhanced MRI can be a promising noninvasive examination for assessing global and regional liver function, allowing estimation of the functional liver remnant and accurate prediction of severe PHLF before hepatic resection.2020年09月, European journal of radiology, 130, 109189 - 109189, 英語, 国際誌研究論文（学術雑誌）
- Please see the Author Video associated with this article. Background: The Vesical Imaging-Reporting and Data System (VI-RADS), based on multiparametric MRI (mp-MRI), was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancer (MIBC). Objective: To evaluate the interobserver agreement and diagnostic performance of VI-RADS among readers with different levels of experience. Methods: This retrospective study included 91 consecutive patients who underwent mp-MRI before transurethral resection of bladder tumor (TURBT) from July 2010 through August 2018. Following a training session, seven radiologists (five radiologists experienced in bladder MRI; two inexperienced radiologists) reviewed and scored all MRI examinations according to VI-RADS. The interobserver agreement was assessed by kappa (κ) statistics. ROC analysis was used to evaluate the diagnostic performance for MIBC. AUCs were estimated. Results: Among 91 patients (72 men, 19 women; age: 73.2±10.2y), 48 (52.7 %) had MIBC, and 43 (47.3%) had NMIBC. Sixty-eight patients were treated with TURBT and 23 were treated with radical cystectomy. Interobserver agreement was moderate to substantial (κ-value range: 0.60-0.80) among the experienced readers, substantial (κ-value: 0.67) between the two inexperienced readers, and moderate to substantial (κ-value range: 0.55-0.75) between the experienced and inexperienced readers. The pooled AUC was 0.88 (range: 0.82-0.91) and 0.84 (range: 0.83-0.85) for experienced and inexperienced readers, respectively. Using a score of 4 or greater as the cutoff value, the pooled sensitivity and specificity were 74.1% (range: 66.0%-80.9%) and 94.1% (range: 88.6%-97.7%) for experienced readers, and 63.9% (range: 59.6%-68.1%) and 86.4% (range: 84.1%-88.6%) for inexperienced readers. Using a score of 3 or greater as the cutoff value, the pooled sensitivity and specificity, were 83.4% (range: 80.9%-85.1%) and 77.3% (range: 61.4%-88.6%) for experienced readers, and 82.0% (range: 80.9%-83.0%) and 73.9% (range: 72.7%-75.0%) for inexperienced readers. Conclusions: We observed moderate to substantial interobserver agreement and a pooled AUC of 0.87 among radiologists of different expertise using VI-RADS. Clinical Impact: VI-RADS could help determine the depth and range of excision in TURBT, decreasing the risk of complications and enhancing the accuracy of pathological diagnosis.2020年07月, AJR. American journal of roentgenology, 216(5) (5), 1257 - 1266, 英語, 国際誌研究論文（学術雑誌）
- The usefulness of sparse-sampling CT with deep learning-based reconstruction for detection of metastasis of malignant ovarian tumors was evaluated. We obtained contrast-enhanced CT images (n = 141) of ovarian cancers from a public database, whose images were randomly divided into 71 training, 20 validation, and 50 test cases. Sparse-sampling CT images were calculated slice-by-slice by software simulation. Two deep-learning models for deep learning-based reconstruction were evaluated: Residual Encoder-Decoder Convolutional Neural Network (RED-CNN) and deeper U-net. For 50 test cases, we evaluated the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) as quantitative measures. Two radiologists independently performed a qualitative evaluation for the following points: entire CT image quality; visibility of the iliac artery; and visibility of peritoneal dissemination, liver metastasis, and lymph node metastasis. Wilcoxon signed-rank test and McNemar test were used to compare image quality and metastasis detectability between the two models, respectively. The mean PSNR and SSIM performed better with deeper U-net over RED-CNN. For all items of the visual evaluation, deeper U-net scored significantly better than RED-CNN. The metastasis detectability with deeper U-net was more than 95%. Sparse-sampling CT with deep learning-based reconstruction proved useful in detecting metastasis of malignant ovarian tumors and might contribute to reducing overall CT-radiation exposure.MDPI AG, 2020年06月, Applied Sciences, 10(13) (13), 4446 - 4446研究論文（学術雑誌）
- Background Deep learning may help to improve computer-aided detection of volume (CADv) measurement of pulmonary nodules at chest CT. Purpose To determine the efficacy of a deep learning method for improving CADv for measuring the solid and ground-glass opacity (GGO) volumes of a nodule, doubling time (DT), and the change in volume at chest CT. Materials and Methods From January 2014 to December 2016, patients with pulmonary nodules at CT were retrospectively reviewed. CADv without and with a convolutional neural network (CNN) automatically determined total nodule volume change per day and DT. Area under the curves (AUCs) on a per-nodule basis and diagnostic accuracy on a per-patient basis were compared among all indexes from CADv with and without CNN for differentiating benign from malignant nodules. Results The CNN training set was 294 nodules in 217 patients, the validation set was 41 nodules in 32 validation patients, and the test set was 290 nodules in 188 patients. A total of 170 patients had 290 nodules (mean size ± standard deviation, 11 mm ± 5; range, 4-29 mm) diagnosed as 132 malignant nodules and 158 benign nodules. There were 132 solid nodules (46%), 106 part-solid nodules (36%), and 52 ground-glass nodules (18%). The test set results showed that the diagnostic performance of the CNN with CADv for total nodule volume change per day was larger than DT of CADv with CNN (AUC, 0.94 [95% confidence interval {CI}: 0.90, 0.96] vs 0.67 [95% CI: 0.60, 0.74]; P < .001) and CADv without CNN (total nodule volume change per day: AUC, 0.69 [95% CI: 0.62, 0.75]; P < .001; DT: AUC, 0.58 [95% CI: 0.51, 0.65]; P < .001). The accuracy of total nodule volume change per day of CADv with CNN was significantly higher than that of CADv without CNN (P < .001) and DT of both methods (P < .001). Conclusion Convolutional neural network is useful for improving accuracy of computer-aided detection of volume measurement and nodule differentiation capability at CT for patients with pulmonary nodules. © RSNA, 2020 Online supplemental material is available for this article.2020年05月, Radiology, 296(2) (2), 191740 - 191740, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 症例は30歳代男性で、神経線維腫症1型(NF1)で通院中であった。MRIで偶発的に膀胱腫瘤を指摘された。NF1を背景にもち、MRIでの特徴的な信号パターンおよび膀胱鏡で粘膜下腫瘤であったことから、神経線維腫を疑った。根治的切除となると尿路変更術を必要とし、症状がない現状では過大な侵襲であり、かつ切除断端から再発する可能性が高いと考えられ、神経線維腫の診断確定およびmalignant peripheral nerve sheath tumor(MPNST)の除外目的に、三角部の腫瘤よりTUR-BTを施行した。膀胱三角部の腫瘤は容易に切除可能であり、出血もほとんどみられなかった。摘出された腫瘤の組織像では、myxoidな成分を伴う粗な短紡錘形細胞の走行を認め、配列は粗であった。末梢神経に巻き付くように進展する形態を示す部位もみられた。MPNSTを疑うような細胞の異型性はみられなかった。以上より、蔓状神経線維腫と診断された。金原出版(株), 2020年05月, 臨床放射線, 65(5) (5), 487 - 490, 日本語
- OBJECTIVES: This study aimed to evaluate the diagnostic performance of the lung zero-echo time (ZTE) sequence in FDG PET/MRI for detection and differentiation of lung lesions in oncologic patients in comparison with conventional two-point Dixon-based MR imaging. METHODS: In this single-institution retrospective study approved by the institutional review board, 209 patients with malignancies (97 men and 112 women; age range, 17-89 years; mean age, 66.5 ± 12.9 years) underwent 18F-FDG PET/MRI between August 2017 and August 2018, with diagnostic Dixon and ZTE under respiratory gating acquired simultaneously with PET. Image analysis was performed for PET/Dixon and PET/ZTE fused images by two readers to assess the detectability and differentiation of lung lesions. The reference standard was pathological findings and/or the data from a chest CT. The detection and differentiation abilities were evaluated for all lesions and subgroups divided by lesion size and maximum standardized uptake value (SUVmax). RESULTS: Based on the reference standard, 227 lung lesions were identified in 113 patients. The detectability of PET/ZTE was significantly better than that of PET/Dixon for overall lesions, lesions with a SUVmax less than 3.0 and lesions smaller than 4 mm (p < 0.01). The diagnostic performance of PET/ZTE was significantly better than that of PET/Dixon for overall lesions and lesions smaller than 4 mm (p < 0.01). CONCLUSIONS: ZTE can improve diagnostic performance in the detection and differentiation of both FDG-avid and non-FDG-avid lung lesions smaller than 4 mm in size, yielding a promising tool to enhance the utility of FDG PET/MRI in oncology patients with lung lesions. KEY POINTS: • The detection rate of PET/ZTE for lesions with a SUVmax of less than 1.0 was significantly better than that of PET/Dixon. • The performance for differentiation of PET/ZTE for lesions that were even smaller than 4 mm in size were significantly better than that of PET/Dixon. • Inter-rater agreement of PET/ZTE for the differentiation of lesions less than 4 mm in size was substantial and better than that of PET/Dixon.2020年04月, European radiology, 30(9) (9), 4995 - 5003, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 38 - 38, 日本語子宮広間膜に発生した平滑筋肉腫の1例
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 40 - 40, 日本語線維軟骨塞栓症が疑われた若年者脊髄梗塞の1例[査読有り]
- (公社)日本医学放射線学会, 2020年02月, Japanese Journal of Radiology, 38(Suppl.) (Suppl.), 45 - 45, 日本語若年者に発症した中枢神経カンジダ髄膜炎の1例[査読有り]
- 2020年, Polish journal of radiology, 85, e67-e81 - e81, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2019年11月, European radiology, 29(11) (11), 6172 - 6181[査読有り]
- A Vesical Imaging-Reporting and Data System (VI-RADS) based on multiparametric magnetic resonance imaging (mp-MRI) was developed to provide accurate information for the diagnosis of muscle-invasive bladder cancers (MIBCs). In this study we evaluated the interobserver agreement and diagnostic performance of VI-RADS. We retrospectively evaluated data for 74 consecutive patients with bladder cancer who had undergone mp-MRI before transurethral resection in a single institution from January 2010 to August 2018. Five readers assessed the probability of the presence of MIBC using VI-RADS scores. The interobserver agreement was assessed by measuring intraclass correlation coefficients (ICCs). Receiver operating characteristic (ROC) analysis was used to evaluate the MIBC diagnostic performance. The area under the ROC curve (AUC) was estimated for ordinal score assessments. Our study demonstrated that interobserver agreement was excellent among five readers (ICC 0.85, 95% confidence interval 0.80-0.89) and the diagnostic performance of VI-RADS was represented as a pooled AUC of 0.90 (95% confidence interval 0.87-0.93). PATIENT SUMMARY: We evaluated the interobserver agreement and diagnostic performance of a new scoring system based on magnetic resonance imaging called a Vesical Imaging-Reporting and Data System (VI-RADS) for muscle-invasive bladder cancer. Our results indicate that VI-RADS is suitable as a comprehensive tool for appropriate treatment planning for patients with bladder cancer.2019年07月, European urology, 76(1) (1), 54 - 56, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- (株)学研メディカル秀潤社, 2019年05月, 画像診断, 39(7) (7), 733 - 744, 日本語
- (株)メジカルビュー社, 2019年05月, 臨床画像, 35(5) (5), 530 - 538, 日本語
- (株)学研メディカル秀潤社, 2019年04月, 画像診断, 39(6) (6), 623 - 631, 日本語
- 2018年12月, Diagn Interv Imaging, 99(12) (12), 773 - 781, 英語Enhancement of breast cancer on pre-treatment dynamic contrast-enhanced MRI using computer-aided detection is associated with response to neo-adjuvant chemotherapy[査読有り]研究論文（学術雑誌）
- 2018年09月, KOREAN JOURNAL OF RADIOLOGY, 19(5) (5), 832 - 837, 英語[査読有り]
- 「産婦人科の進歩」編集室, 2018年05月, 産婦人科の進歩, 70(2) (2), 218 - 218, 日本語PPAPスコアリングシステムを用いた前置胎盤の管理
- INTRODUCTION: Placenta previa (PP) is one of the most significant risk factors for adherent placenta (AP). The aim of this study was to evaluate the diagnostic efficacy of a novel scoring system for predicting AP in pregnant women with PP. METHODS: This prospective cohort study enrolled 175 women with PP. The placenta previa with adherent placenta score (PPAP score) is composed of 2 categories: (1) past history of cesarean section (CS), surgical abortion, and/or uterine surgery; and (2) ultrasonography and magnetic resonance imaging findings. Each category is graded as 0, 1, 2, or 4 points, yielding a total score between 0 and 24. When women with PP had PPAP score ≥8, they were considered to be at a high risk for AP and received placement of preoperative internal iliac artery occlusion balloon catheters. If they were found to have AP during CS, they underwent hysterectomy or placenta removal using advanced bipolar with balloon catheter occlusion. The predictive accuracy of PPAP score was evaluated. RESULTS: In total, 23 of the 175 women with PP were diagnosed as having AP, histopathologically or clinically. Twenty-one of 24 women with PPAP score ≥8 had AP, whereas two of 151 women with PPAP score <8 had AP. The scoring system yielded 91.3% sensitivity, 98.0% specificity, 87.5% positive predictive value, and 98.7% negative predictive value for predicting AP in women with PP. DISCUSSION: This prospective study demonstrated that PPAP scoring system may be useful for predicting AP in women with PP.2018年04月, Placenta, 64, 27 - 33, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2018年02月, Radiology, 286(2) (2), 412 - 420, 英語[査読有り]研究論文（学術雑誌）
- 2017年12月, JAPANESE JOURNAL OF RADIOLOGY, 35(12) (12), 707 - 717, 英語[査読有り]研究論文（学術雑誌）
- 2017年09月, RADIOLOGY, 284(3) (3), 748 - 757, 英語[査読有り]研究論文（学術雑誌）
- 2017年, EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 38(5) (5), 815 - 817, 英語[査読有り]研究論文（学術雑誌）
- 2017年, BRITISH JOURNAL OF RADIOLOGY, 90(1075) (1075), 20170035, 英語[査読有り]研究論文（学術雑誌）
- John Wiley and Sons Inc., 2016年09月, Journal of Magnetic Resonance Imaging, 44(3) (3), 573 - 583, 英語[査読有り]研究論文（学術雑誌）
- 2016年07月, INTERNATIONAL JOURNAL OF UROLOGY, 23(7) (7), 550 - 557, 英語[査読有り]研究論文（学術雑誌）
- 2016年05月, RADIOLOGY, 279(2) (2), 578 - 589, 英語[査読有り]研究論文（学術雑誌）
- 2016年02月, Japanese Journal of Radiology, 34(Suppl.) (Suppl.), 53, 日本語精巣原発形質細胞腫の1例研究論文（その他学術会議資料等）
- 2016年01月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 43(1) (1), 138 - 148, 英語[査読有り]研究論文（学術雑誌）
- 2015年07月, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42(8) (8), 1268 - 1275, 英語[査読有り]研究論文（学術雑誌）
- 2015年04月, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 187, 41 - 44, 英語[査読有り]研究論文（学術雑誌）
- 2015年04月, BRITISH JOURNAL OF RADIOLOGY, 88(1048) (1048), 20140738 - 20140738, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2015年01月, PLOS ONE, 10(1) (1), e0117411, 英語[査読有り]研究論文（学術雑誌）
- 腹腔鏡下手術後7年後に発見され、骨盤内から後腹膜腔へ発達した巨大なparasitic myomaの1例47歳女。39歳時に腹腔鏡下子宮筋腫核出術、40歳時に甲状腺乳頭癌に対して甲状腺摘出術の既往があった。無月経、不正性器出血で受診した際に、骨盤内から後腹膜腔へ発達する巨大な腫瘍を指摘された。PET-CTでは腫瘍部位にFDGの有意な集積を認めず、有茎性漿膜下筋腫を疑った。原発不明腫瘍の診断で手術を施行した。病理組織では、腹腔鏡下子宮筋腫核出術の既往があることから、腹腔鏡下筋腫核出術後に発生した医原性parasitic myomaと推察した。当時の手術記録を取り寄せたところ、子宮後壁頸部近くの97mm大の筋腫を核出後、モルセレーターを使用し体外に摘出していた。その際の残存筋腫が栄養血管を獲得しながら発育し、後腹膜腔にまで達する巨大なparasitic myomaとなったと推測された。腫瘍および子宮頸部・体部細胞診において悪性所見は認めず、不正性器出血に関しては閉経周辺期の機能性子宮出血と考えられた。「産婦人科の進歩」編集室, 2014年10月, 産婦人科の進歩, 66(4) (4), 361 - 366, 日本語[査読有り]研究論文（学術雑誌）
- 2014年07月, CLINICAL IMAGING, 38(4) (4), 464 - 469, 英語[査読有り]研究論文（学術雑誌）
- 2014年05月, CLINICAL IMAGING, 38(3) (3), 302 - 306, 英語[査読有り]研究論文（学術雑誌）
- 2014年04月, 日本泌尿器科学会総会 102回, 367, 日本語前立腺の生検前MRI 有用性と問題点 前立腺癌検出におけるmultiparametric MRIの意義 生検前後の癌検出能の比較[査読有り]研究論文（その他学術会議資料等）
- 2014年04月, EUROPEAN RADIOLOGY, 24(4) (4), 881 - 888, 英語[査読有り]研究論文（学術雑誌）
- 2014年02月, 日本放射線技術学会総会学術大会予稿集, (70回) (70回), 202, 日本語Variable refocusing flip angle法を用いた前立腺3D-T2強調画像のコントラスト比と解像特性について[査読有り]研究論文（その他学術会議資料等）
- Kanehara Shuppan Co. Ltd, 2014年, Japanese Journal of Clinical Radiology, 59(6) (6), 849 - 853, 日本語A case of intranvenous hemangioma originating in renal vein研究論文（学術雑誌）
- 2014年01月, ANNALS OF NUCLEAR MEDICINE, 28(1) (1), 25 - 32, 英語[査読有り]研究論文（学術雑誌）
- 2013年12月, EUROPEAN RADIOLOGY, 23(12) (12), 3509 - 3516, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本婦人科腫瘍学会, 2013年10月, 日本婦人科腫瘍学会雑誌, 31(4) (4), 1062 - 1067, 日本語子宮留膿腫を契機に発見された子宮体部原発扁平上皮癌の1症例[査読有り]研究論文（学術雑誌）
- 2013年10月, EUROPEAN JOURNAL OF RADIOLOGY, 82(10) (10), 1672 - 1676, 英語[査読有り]研究論文（学術雑誌）
- OBJECTIVE: To investigate the usefulness of apparent diffusion coefficient (ADC) values in predicting true Gleason scores from radical prostatectomy specimen (tGS), compared with systematic transrectal ultrasound (TRUS)-guided biopsy GS (bGS). MATERIALS AND METHODS: One hundred and five patients with biopsy-proven prostate cancer underwent preoperative DWI (b-values of 0, 1000, and 2000s/mm(2)) of 3-T MRI. The mean and minimum ADCs of visible tumors were calculated for either of a pair of b-values: 0 and 1000s/mm(2) (ADC1000), or 0 and 2000s/mm(2) (ADC2000), and relationships between the four ADC parameters and tGS evaluated for the peripheral zone (PZ) and transition zone (TZ). For multiple tumors, the dominant tumor's GS and ADCs were estimated for cancer aggressiveness assessment by computing ROC curves. RESULTS: Significant negative correlations were observed between tGS and mean ADC1000, mean ADC2000, minimum ADC1000, and minimum ADC2000 (r=-0.41, -0.39, -0.39, and -0.37, respectively) of 100 visible PZ tumors and 66 visible TZ tumors (r=-0.40, -0.42, -0.29, and -0.21, respectively). For distinguishing high-grade from low/intermediate-grade PZ lesions, the areas under the curve (AUCs) of mean ADC1000 (0.751), mean ADC2000 (0.710), minimum ADC1000 (0.768), and minimum ADC2000 (0.752) were similar to that of the highest bGS (0.708) (p=0.61, p=0.98, p=0.47, and p=0.60, respectively). For distinguishing high-grade from low/intermediate-grade TZ lesions, AUCs of mean ADC1000 (0.779), and mean ADC2000 (0.811) were similar to that of the highest bGS (0.805) (p=0.83 and p=0.97). CONCLUSION: Tumor ADCs obtained with high b-values could predict prostate cancer aggressiveness as effectively as systematic TRUS-guided biopsy.2013年08月, European journal of radiology, 82(8) (8), 1219 - 26, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- PURPOSE: To determine, with histopathological findings of radical prostatectomy as reference, whether diffusion-weighted imaging (DWI) using b = 2000 s/mm(2) for 3-T magnetic resonance imaging (MRI) is superior to the use of b = 1000 s/mm(2) for prostate cancer detection. MATERIALS AND METHODS: This study evaluated 73 patients with biopsy-proven prostate cancer. All patients underwent preoperative 3-T MRI using T2-weighted imaging (T2WI) and DWI (b = 0, 1000, 2000 s/mm(2) ). The following three sets of images were evaluated separately by two radiologists: protocol A (T2WI alone), protocol B (T2WI and DWI with b = 1000 s/mm(2) ), and protocol C (T2WI and DWI with b = 2000 s/mm(2) ). For estimation of diagnostic capability, area under the receiver operating characteristic (ROC) curve (AUC) was calculated. RESULTS: A total of 341 cancer foci were found in the prostectomy specimens of 73 patients. Reader 1 rated AUCs of the three sets as; A 0.66, B 0.77, C 0.80. ROC analysis showed significant differences among the three protocols (A vs. B vs. C: P < 0.0001, A vs. B: P < 0.0001, B vs. C: P < 0.0001). CONCLUSION: The use of b = 2000 s/mm(2) for DWI with 3-T MRI is diagnostically superior to that of b = 1000 s/mm(2) for prostate cancer detection.2013年07月, Journal of magnetic resonance imaging : JMRI, 38(1) (1), 154 - 60, 英語, 国際誌[査読有り]研究論文（学術雑誌）
- 2013年02月, 日本医学放射線学会学術集会抄録集, (72回) (72回), S148, 日本語画像診断は前立腺癌の治療戦略にどのように影響しうるか(How recent advances in MR imaging affect treatment strategies for prostate cancer)(英語)[招待有り]研究論文（研究会，シンポジウム資料等）
- (公社)日本医学放射線学会, 2013年02月, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 55 - 55, 日本語非典型的なMRI像を呈した卵巣粘液性嚢胞腺癌の1例[査読有り]研究論文（その他学術会議資料等）
- 2012年11月, EUROPEAN JOURNAL OF RADIOLOGY, 81(11) (11), 3557 - 3562, 英語研究論文（学術雑誌）
- 2012年07月, JOURNAL OF MAGNETIC RESONANCE IMAGING, 36(1) (1), 198 - 205, 英語[査読有り]研究論文（学術雑誌）
- (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S207 - S207, 日本語肺癌患者の全身3T MRIにおけるQuick 3D with Enhanced Fat Freeの有用性に関する検討[査読有り]研究論文（その他学術会議資料等）
- (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 72回(71回) (71回), S217 - S225, 日本語前立腺癌検出におけるcomputed DWIの有用性 初期報告[査読有り]研究論文（その他学術会議資料等）
- (公社)日本医学放射線学会, 2012年02月, 日本医学放射線学会学術集会抄録集, 71回(71回) (71回), S217 - S217, 日本語3テスラMRI装置での拡散強調画像における、視覚的な前立腺癌検出能に与えるb値の影響[査読有り]研究論文（その他学術会議資料等）
- 2012年, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 11(1) (1), 71 - 74, 英語Diffusion-weighted Imaging of a Malignant Brenner Tumor[査読有り]研究論文（学術雑誌）
- 2011年11月, JAPANESE JOURNAL OF RADIOLOGY, 29(9) (9), 605 - 608, 英語研究論文（学術雑誌）
- 金原出版(株), 2025年07月, 臨床放射線, 70(4) (4), 593 - 597, 日本語
- 医学図書出版(株), 2025年07月, 肝臓クリニカルアップデート, 11(1) (1), 61 - 67, 日本語
- (公社)日本医学放射線学会, 2025年02月, Japanese Journal of Radiology, 43(Suppl.) (Suppl.), 27 - 27, 日本語UAE後に発見されたIntravenous leiomyomatosisの1例
- (株)Gakken, 2025年, 画像診断, 45(2) (2), 156 - 157, 日本語エキスパートをめざす産婦人科の画像診断 Case-based review 1 卵巣・卵管・腹膜 6 妊娠中に判明した非常に稀な卵巣腫瘍の一例
- 金原出版(株), 2025年, 臨床放射線, 70(3) (3), 397 - 403, 日本語自己免疫疾患の画像診断 腹部:実質臓器(副腎・泌尿生殖器)
- 2024年, 画像診断, 44(7) (7)治療に役立つ腹部画像診断レポートのポイント 6 前立腺 5 前立腺癌-精嚢浸潤評価のポイント
- 2024年, 画像診断, 44(7) (7)治療に役立つ腹部画像診断レポートのポイント 6 前立腺 3 前立腺癌-移行域癌を検出するポイント
- 2024年, 画像診断, 44(7) (7)治療に役立つ腹部画像診断レポートのポイント 6 前立腺 2 前立腺癌-辺縁域癌(および中心域癌)を検出するポイント
- 2024年, 画像診断, 44(7) (7)治療に役立つ腹部画像診断レポートのポイント 6 前立腺 4 前立腺癌-被膜外浸潤評価のポイント
- (株)Gakken, 2024年, 画像診断, 44(7) (7), 686 - 698, 日本語治療に役立つ腹部画像診断レポートのポイント 6 前立腺 1 前立腺癌-画像診断レポートに記載すべき項目:総論
- (公社)日本医師会, 2024年, 日本医師会雑誌, 153(特別1) (特別1), S309 - S311, 日本語泌尿生殖器 前立腺がん
- (株)メジカルビュー社, 2024年, 臨床画像, 40(7) (7), 838 - 846, 日本語未来の病態を予測する読影法 産婦人科領域で予測しておきたいこと
- 2024年, 泌尿器画像診断・治療技術研究会プログラム・抄録集, 11th膀胱癌の画像診断の現状と課題
- (公社)日本医学放射線学会, 2024年, 日本医学放射線学会秋季臨床大会抄録集, 60th, S371 - S371, 日本語前立腺癌診断におけるマルチパラメトリックMRIの役割
- 2024年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 25th術前MRIと術後病理の深部筋層浸潤診断が乖離し,腫瘍の急速増大がその原因と推定された子宮類内膜癌の1例
- (株)日本臨床社, 2023年06月, 日本臨床, 81(増刊6 臨床前立腺癌学) (増刊6 臨床前立腺癌学), 142 - 148, 日本語
- (NPO)日本緩和医療学会, 2023年, Palliative Care Research, 18(2) (2), 123 - 128, 日本語
- 2023年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 24th妊娠中に判明した,非常に稀な悪性卵巣甲状腺腫(低分化癌)の1例
- 2023年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 24th腎細胞癌術後4年目に卵巣転移を来した1例
- 2023年, 泌尿器画像診断・治療技術研究会プログラム・抄録集, 10thPI-RR&PI-QUAL scoring system:前立腺癌の局所再発診断とmpMRI画質評価
- 2022年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 23rd脂肪平滑筋腫との鑑別が困難であった,骨盤内血管筋脂肪腫の1例
- 産業開発機構(株), 2021年12月, 映像情報Medical, 53(14) (14), 106 - 113, 日本語
- (一社)日本泌尿器科学会総会事務局, 2021年12月, 日本泌尿器科学会総会, 109回, PP30 - 07, 日本語前立腺生検における狙撃生検及び系統的生検の有用性について 導管内癌(IDC-P)に狙撃生検は可能か?
- (公社)日本放射線技術学会, 2021年09月, 日本放射線技術学会雑誌, 77(9) (9), 1035 - 1035, 日本語Multi Band EPIを用いた膀胱Isotropic-voxel DWIの基礎的検討
- 日本腎泌尿器疾患予防医学研究会, 2021年05月, 日本腎泌尿器疾患予防医学研究会誌, 29(1) (1), 84 - 85, 日本語当院におけるUS-MRI前立腺fusion biopsyの臨床成績
- 症例は70歳代女性で、帯下、不正性器出血を主訴に受診し、子宮に腫瘤性病変を指摘された。MRIでは子宮体部に91×73×78mm大の腫瘤を認めた。画像所見からは子宮肉腫が疑われたが、由来部位が同定困難であり、非類内膜腺癌なども鑑別に挙げられた。腫瘤は複数の成分からなっており、T2強調像では腹側部は低信号、背頭部は比較的高信号、背尾側部は中程度の高信号を呈していた。18F-FDG PETでは腹側部はFDG集積が弱く、背頭部には軽度の集積、背尾部に強い集積を認めた。肉眼所見では子宮内腔に腫瘤が充満していた。画像所見にみられた腫瘍の各成分についての病理学的な特徴は以下のとおりであった。腫瘤腹側部には、異型の乏しい腺管構造が散見され、大小不同の核を呈する紡錘形細胞が認められた。腫瘤背頭部には、典型性の強い紡錘形細胞が多数認められ、正常な腺構造は認められなかった。腫瘤背頭部では、異型性の強い紡錘形細胞や壊死組織、炎症細胞が多数認められた。細胞密度は高く、正常な腺構造は認められなかった。根治的手術(子宮全摘術および両側付属器切除)が実施され、病理学的に腺肉腫の診断がなされた。子宮筋層の深部浸潤があり、pT1c FIGO IC期相当と判断された。術後特に問題なく退院となったが、術後2年3ヵ月で多発肺転移が生じた。全身状態良好であり、転移病変の増大が遅い点から経過観察の方針となり、術後3年9ヵ月時点では無症状で生存している。金原出版(株), 2021年04月, 臨床放射線, 66(4) (4), 381 - 385, 日本語
- (株)メジカルビュー社, 2021年04月, 臨床画像, 37(4月増刊) (4月増刊), 128 - 150, 日本語
- (株)メジカルビュー社, 2021年04月, 臨床画像, 37(4) (4), 490 - 497, 日本語
- 金原出版(株), 2021年04月, 臨床放射線, 66(4) (4), 381 - 385, 日本語
- (株)診断と治療社, 2021年03月, 産科と婦人科, 88(Suppl.) (Suppl.), 384 - 392, 日本語
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 22nd当院で経験した子癇の画像診断
- Springer Science and Business Media Deutschland GmbH, 2021年, Magnetic Resonance Materials in Physics, Biology and Medicine, 英語書評論文,書評,文献紹介等
- 2021年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 22nd (CD-ROM)50歳代女性に生じ術前診断が困難であった卵巣卵黄嚢腫瘍の一例
- 2021年, 日本神経放射線学会プログラム・抄録集, 50th脊髄に発生したdiffuse midline glioma,H3K27M-mutantの3例
- 日本腎泌尿器疾患予防医学研究会, 2021年01月, 日本腎泌尿器疾患予防医学研究会プログラム・抄録集, 29回, 38 - 38, 日本語当院におけるUS-MRI fusion biopsyの臨床成績
- (株)メジカルビュー社, 2021年01月, 臨床画像, 37(1) (1), 140 - 147, 日本語【主治医が求める読影レポートの書き方】泌尿生殖器領域に求められるレポートの書き方
- 2021年, 臨床画像, 37(2) (2)地力が伸ばせる腹部画像診断:婦人科・腎・泌尿器 卵巣腫瘍・卵巣茎捻転
- (一社)日本泌尿器科学会総会事務局, 2020年12月, 日本泌尿器科学会総会, 108回, 311 - 311, 日本語前立腺癌根治療法後のPSA再発:次の一手は 前立腺癌治療後再発におけるマルチパラメトリックMRIの役割
- バイエル薬品(株), 2020年12月, 日独医報, 65(1) (1), 55 - 63, 日本語【マネジメントに苦慮する疾患:Is it benign,malignant or insignificant?】前立腺clinically insignificant cancerの診断とマネジメントにおけるMRIの役割
- (株)学研メディカル秀潤社, 2020年10月, 画像診断, 40(13) (13), 1299 - 1310, 日本語
- (株)学研メディカル秀潤社, 2020年04月, 画像診断, 40(6) (6), 555 - 564, 日本語
- 泌尿器科紀要刊行会, 2020年03月, 泌尿器科紀要, 66(3) (3), 100 - 100, 日本語下大静脈平滑筋肉腫の1例
- 泌尿器科紀要刊行会, 2020年02月, 泌尿器科紀要, 66(2) (2), 60 - 60, 日本語下大静脈腫瘍塞栓を伴う腎癌症例におけるCineMRIの有用性
- (公社)日本医学放射線学会, 2019年09月, 日本医学放射線学会秋季臨床大会抄録集, 55回, S558 - S558, 日本語気管内挿管後に舌壊死を来した1例
- 日本腎泌尿器疾患予防医学研究会, 2019年07月, 日本腎泌尿器疾患予防医学研究会プログラム・抄録集, 28回, 34 - 34, 日本語当院におけるUS-MRI fusion biopsyの初期経験
- 金原出版(株), 2019年06月, 産婦人科の実際, 68(7) (7), 934 - 939, 日本語【産婦人科診療decision makingのためのMRI・CT】胎盤・妊娠関連 癒着胎盤の画像診断
- (NPO)日本CT検診学会, 2019年02月, CT検診, 26(1) (1), 47 - 47, 日本語肺結節自動容積測定(Computer-Aided Volumetry)によるConvolutional Neural Networkの有用性に関する検討
- 2019年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th筋腫分娩様の所見を呈し,術前診断が困難であった子宮平滑筋肉腫の1例
- 2019年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging (CD-ROM), 20th卵巣腫瘍と鑑別を要した肝細胞癌の骨盤内播種
- 2019年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 7th前立腺移行域癌診断におけるQuantitative Multiparametric MRIの有用性
- 2019年, 日本神経放射線学会プログラム・抄録集, 48th, 101, 日本語静脈洞血栓をきたしたRendu‐Osler‐Weber病の一例
- (一社)日本核医学会, 2018年11月, 核医学, 55(Suppl.) (Suppl.), S209 - S209, 英語FDG PET/MRにおける呼吸同期下MR吸収補正と画像再構成法の影響
- (公社)日本医学放射線学会, 2018年09月, 日本医学放射線学会秋季臨床大会抄録集, 54回(54回) (54回), S536 - S536, 日本語翼口蓋窩に生じた筋上皮腫の1例会議報告等
- Radiation therapy is a useful treatment for tumors and vascular malformations of the central nervous system. Radiation therapy is associated with complications, including leukoencephalopathy, radiation necrosis, vasculopathy, and optic neuropathy. Secondary tumors are also often seen long after radiation therapy. Secondary tumors are often benign tumors, such as hemangiomas and meningiomas, but sometimes malignant gliomas and soft tissue sarcomas emerge. We review the imaging findings of complications that may occur after brain radiation therapy.2018年09月, Jpn J Radiol, 36(9) (9), 519 - 527, 英語, 国内誌[査読有り]記事・総説・解説・論説等（学術雑誌）
- Radiological Society of North America Inc., 2018年03月01日, Radiology, 286(3) (3), 1093 - 1094, 英語[査読有り]速報，短報，研究ノート等（学術雑誌）
- (公社)日本医学放射線学会, 2018年02月, Japanese Journal of Radiology, 36(Suppl.) (Suppl.), 37 - 37, 日本語腎腫瘤と肺嚢胞を認め、Birt-Hogg-Dube(BHD)症候群と遺伝子診断された2例その他
- 2018年, Abstracts. Annual Symposium. Japanese Society for the Advancement of Women’s Imaging, 19th胎児臍帯ヘルニア破裂の一例
- (一社)日本泌尿器内視鏡・ロボティクス学会, 2018年, Japanese Journal of Endourology, 31(3 (Web)) (3 (Web)), P - 3, 日本語当院におけるロボット支援根治的前立腺全摘除術における拡大リンパ節郭清の検討
- 2018年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 6th, 27, 日本語低侵襲手術に対応する病期診断
- 2018年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 6th, 45, 日本語下大静脈腫瘍塞栓を伴う腎癌症例におけるcine MRIの有用性
- 2018年, 泌尿器画像診断・治療技術研究会プログラム・抄録, 6th, 51, 日本語腎腫瘍のFDG‐PET:画像と病理所見の対比
- Radiological Society of North America Inc., 2017年12月01日, Radiology, 285(3) (3), 1055 - 1056, 英語速報，短報，研究ノート等（学術雑誌）
- (株)学研メディカル秀潤社, 2017年12月, 画像診断, 38(1) (1), 46 - 60, 日本語【腹部感染症の画像診断update】腎感染症 画像診断では何に注目すべきか?
- (株)東京医学社, 2017年12月, 腎と透析, 83(6) (6), 890 - 896, 日本語【ここまで進んだ腎泌尿器疾患の画像診断】この疾患はこの画像でこう診断する 上部尿路上皮癌におけるCTとMRIの位置づけ記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2017年11月, NAGOYA JOURNAL OF MEDICAL SCIENCE, 79(4) (4), 527 - 543, 英語[査読有り]書評論文,書評,文献紹介等
- (株)日本臨床社, 2017年10月, 日本臨床, 75(増刊7 新腎・泌尿器癌(下)) (増刊7 新腎・泌尿器癌(下)), 133 - 137, 日本語【新腎・泌尿器癌(下)-基礎・臨床研究の進歩-】膀胱癌 膀胱癌の検査・診断 膀胱癌の診断 画像診断 膀胱癌転移巣の画像診断記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本核医学会, 2017年09月, 核医学, 54(Suppl.) (Suppl.), S193 - S193, 日本語F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討 FDG集積とMRI信号との対比記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (公社)日本医学放射線学会, 2017年08月, 日本医学放射線学会秋季臨床大会抄録集, 53回(53回) (53回), S380 - S380, 日本語腎腫瘍Up to date 腎癌の診療方針決定における画像診断の役割記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)日本臨床社, 2017年08月, 日本臨床, 75(増刊6 新腎・泌尿器癌(上)) (増刊6 新腎・泌尿器癌(上)), 187 - 192, 日本語【新腎・泌尿器癌(上)-基礎・臨床研究の進歩-】腎癌 腎癌の検査・診断 腎癌の診断 画像診断 腎良性病変の画像診断記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2017年07月, 画像診断, 37(9号) (9号), 926 - 929, 日本語【サインから読み解く婦人科画像診断】 癒着胎盤に関連するサイン 癒着胎盤に関連するサイン[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)インナービジョン, 2017年07月, INNERVISION, 32(8) (8), 48 - 50, 日本語【Women's Imaging 2017 Female Pelvis Imaging Vol.5 骨盤内女性臓器疾患における機能イメージングの可能性】骨盤内女性臓器疾患における機能イメージングの現状と展望 MRIによる機能イメージング テクスチャ解析の臨床的有用性記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 金原出版, 2017年05月, 臨床放射線, 62(5) (5), 719 - 723, 日本語症例 Polypoid endometriosisの2例
- 2017年05月, JOURNAL OF NUCLEAR MEDICINE, 58, 英語Integrated FDG-PET/MRI for whole-body staging in patients with recurrent gynecological cancer研究発表ペーパー・要旨（国際会議）
- Radiological Society of North America Inc., 2017年03月01日, Radiology, 282(3) (3), 923, 英語速報，短報，研究ノート等（学術雑誌）
- 2017年03月, RADIOLOGY, 282(3) (3), 923 - 923, 英語Reliability of Measurement of Chemical Exchange Saturation Transfer Effects for Lung Lesions Response速報，短報，研究ノート等（学術雑誌）
- (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 45 - 45, 日本語卵管癌との鑑別に苦慮した活動性卵管炎の1例
- (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 45 - 45, 日本語PTEN過誤腫症候群を背景とした腎細胞癌の1例
- (一社)日本核医学会, 2017年02月, 核医学, 54(1) (1), 671 - 671, 日本語PET-MRIが有用であった平滑筋肉腫合併子宮体癌の1例
- バイエル薬品(株), 2017年, 日獨医報, 62(1) (1), 44 - 52, 日本語前立腺癌の画像診断 5.MRIによる前立腺癌の検出-PI-RADS version 2を臨床レポートにどのように取り入れていくか-記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 医学図書出版, 2016年10月, Prostate Journal, 3(2号) (2号), 151 - 156, 日本語【前立腺癌と骨-骨の特殊性を科学する-】 骨転移巣の画像診断記事・総説・解説・論説等（その他）
- 2016年05月, INNERVISION, 31(6号) (6号), 30 - 35, 日本語前立腺MRI診断の標準化に向けて PI-RADS version 2の概要 PI-RADS Section II、Appendix II 前立腺の正常解剖と良性疾患記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2016年05月, 日本臨床, 74(増刊3 新前立腺癌学) (増刊3 新前立腺癌学), 318 - 322, 日本語【新前立腺癌学-最新の基礎研究と診断・治療-】 前立腺癌の検査・診断 画像診断 前立腺癌診療におけるCT、PET-CTの位置づけ記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2015年12月, 画像診断, 6(1) (1), 51 - 58, 日本語骨盤部感染症の画像診断-迅速な診断と治療のストラテジー 泌尿器領域の骨盤内感染症[招待有り]記事・総説・解説・論説等（学術雑誌）
- 2015年10月, PLACENTA, 36(10) (10), A5 - A6, 英語PREDICTION OF ADHERENT PLACENTA IN PATIENTS WITH PLACENTA PREVIA USING ULTRASONOGRAPHY AND MAGNETIC RESONANCE IMAGING研究発表ペーパー・要旨（国際会議）
- 産業開発機構(株), 2014年12月, 映像情報Medical, 46(14号) (14号), 86 - 90, 日本語【ROUTINE CLINICAL MRI 2015 BOOK】 Computed diffusion-weighted imaging[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 金原出版, 2014年10月, 臨床放射線, 59(11号) (11号), 1475 - 1484, 日本語【悪性リンパ腫の診断と治療】 画像診断 鑑別診断に重点をおいて 腎(副腎)・泌尿器・生殖器[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (公社)日本医学放射線学会, 2014年09月, 日本医学放射線学会秋季臨床大会抄録集, 50回(50回) (50回), S674 - S674, 英語侵襲性の前置胎盤 MR imaging scoring systemによる予備的検証(Invasive placenta previa: preliminary validation of an MR imaging scoring system)(英語)会議報告等
- 2014年09月, 画像診断, 34(12号) (12号), 1296 - 1305, 日本語【泌尿器疾患のガイドライン-診療の流れと画像検査の位置づけ-】 腎盂尿管癌[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2014年08月, 臨床画像, 30(8号) (8号), 892 - 899, 日本語【シェーマで納得!基礎から学べるCT/MRI腹部画像診断に役立つサイン】 膀胱・前立腺・精巣[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 金原出版, 2014年06月, 臨床放射線, 59(6号) (6号), 849 - 853, 日本語【腹部の最新画像情報2014】 腎静脈内血管腫の1例[査読有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2014年04月, JOURNAL OF UROLOGY, 191(4) (4), E73 - E73, 英語VISUALIZATION OF PERIPROSTATIC NERVE FIBERS BEFORE AND AFTER RADICAL PROSTATECTOMY USING DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING WITH TRACTOGRAPHY研究発表ペーパー・要旨（国際会議）
- 2014年, 核医学症例検討会症例集, 35(1) (1)MRIで子宮平滑筋肉腫を強く疑われたが,FDG-PETで子宮筋腫と診断できた2例
- 2013年12月, 画像診断, 34(1号) (1号), 84 - 85, 日本語【いま、注目の疾患2014】 女性生殖器(症例5) 癒着胎盤[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 産業開発機構, 2013年11月, 映像情報Medical, 45(12号) (12号), 930 - 935, 日本語【骨盤部疾患の診断とIVRの現況】 前立腺癌の画像診断[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2013年09月, 日本癌治療学会誌, 48(3号) (3号), 684, 日本語がん画像診断の最前線 泌尿器癌治療戦略に最新の画像診断はどう影響しうるか?[招待有り]講演資料等（セミナー，チュートリアル，講習，講義他）
- 2013年05月, 臨床画像, 29(5号) (5号), 592 - 598, 日本語【尿路画像診断:知らなくてはならない非腫瘍性疾患】 尿路結石・腎石灰化症[査読有り][招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2013年04月, 臨床画像, 29, 158 - 167, 日本語ケースレビュー: 画像診断必修知識習得のための指導医と研修医の問答集 序説.記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (株)学研メディカル秀潤社, 2013年03月, 画像診断, 33(4号) (4号), s131 - s152, 日本語[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- 2012年09月, INTERNATIONAL JOURNAL OF UROLOGY, 19(9) (9), 806 - 811, 英語[査読有り]書評論文,書評,文献紹介等
- 2012年02月, 画像診断, 32(3号) (3号), 266 - 275, 日本語【泌尿器・婦人科画像診断step further-低侵襲治療時代の主治医の視点-】 前立腺癌 手術前に知りたい画像情報[招待有り]記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）
- (一社)日本核医学会, 2011年11月, 核医学, 48(4) (4), 467 - 467, 日本語FDG集積をきたした卵巣Leydig cell tumorの一例
- 分担執筆, 14. 子宮, 秀潤社, 2022年02月画像診断２０２２年増刊号（Ｖｏｌ．42 Ｎｏ．4） 楠本昌彦編著
- 金原出版, 2021年09月, 日本語, ISBN: 9784307071239画像診断ガイドライン
- メジカルビュー社, 2021年04月, 日本語, ISBN: 9784758316170泌尿器領域画像診断の勘ドコロNEO
- 共著, 子宮内膜癌のMRI, 秀潤社, 2020年10月, 1299-1310, 日本語画像診断11月号 診断を決める！婦人科画像診断のルールブック[査読有り]学術書
- 分担執筆, 【読影サインが表す病態・疾患】, 文光堂, 2020年09月一冊でわかる婦人科腫瘍の画像診断
- 共著, American College of Radiology, 2020年05月, 18, 英語, The ACR Appropriateness Criteria are evidence-based guidelines to assist referring physicians and other providers in making the most appropriate imaging or treatment decision for PRETREATMENT EVALUATION AND FOLLOW-UP OF ENDOMETRIAL CANCERPRETREATMENT EVALUATION AND FOLLOW-UP OF ENDOMETRIAL CANCERその他
- 分担執筆, 【胎盤疾患】, メディカル・サイエンス・インターナショナル, 2020年03月症例から学ぶ産婦人科疾患の画像診断
- 分担執筆, 【前立腺の稀な腫瘍】【副腎オンコサイトーマ】, 秀潤社, 2019年知っておきたい泌尿器のCT・MRI 第2版
- 2025 ISMRM & ISMRT Annual Meeting & Exhibition, 2025年05月Benefit of PI-RADS[招待有り]
- ゲルベ・ジャパンWebセミナー, 2022年02月臨床に役立つ骨盤領域の画像診断 子宮頚癌・体癌の病期診断[招待有り]
- 第14回広島画像診断研究会, 2021年09月前立腺癌の画像診断： multiparametric MRIと biparametric MRIについての最近の話題[招待有り]
- 第57回日本医学放射線学会秋季臨床大会, 2021年09月前立腺癌の治療方針を決める画像診断[招待有り]
- 第8回JSURT(泌尿器画像診断・治療技術研究会), 2021年08月前立腺癌multiparametric MRIとbiparametric MRIについての最近の話題
- 第34回JCRミッドウィンターセミナー, 2021年01月, 日本語放射線科がリンクさせる前立腺癌診療 (診断)[招待有り]
- 第108回日本泌尿器科学会総会, 2020年12月, 日本語前立腺癌根治療法後のPSA再発：次の一手は[招待有り]シンポジウム・ワークショップパネル（指名）
- 第79回日本医学放射線学会総会, 2020年05月, 英語, 日本医学放射線学会, Web開催, "[Objective] To evaluate the inter-observer agreement and diagnostic performa nce of Vesical Imaging-Reporting And Data System (VI-RADS) for muscle-invasi ve bladder cancer (MIBC) , in comparison with Likert scale.[Materials and Me thods] A total of 111 consecutive patients who had undergone mp-MRI before t rans-urethral resection of bladder tumor participated in this study. Five re aders retrospectively assessed the probability of the presence of MIBCs with Likert and VI-RADS scores. The inter-observer agreement was assessed by mea suring intraclass correlation coefficients (ICC). Receiver operating charact eristic (ROC) analysis was used to evaluate the diagnostic performance for M IBCs. Areas under the ROC curves (AUC) were estimated for ordinal score asse ssments.[Results] Out of 111 patients, 57 had MIBCs. Inter-observer agreemen t was excellent for Likert and VI-RADS scores (ICC; 0.81 vs 0.81). AUCs show ed no significant difference between the Likert and VI-RADS scores for all r eaders (P>0.05). [Conclusion] The VI-RADS score showed an excellent inter -observer agreement and high diagnostic performance for MIBCs equivalent to the Likert scale. ", 国内会議膀胱癌診断におけるVI-RADSの妥当性の検討：Likert法との比較ポスター発表
- 第８回兵庫県放射線技師会読影セミナー＆第１５回学術研修フォーラム, 2020年02月前立腺癌におけるマルチパラメトリックMRIの役割[招待有り]口頭発表（招待・特別）
- 第23回MR実践講座, 2019年12月, 日本語, 日本磁気共鳴医学会, 京都, Prostate Imaging and Reporting and Data System (PI-RADS)で推奨されている前立腺MRIの撮像法と読影法について概説する．2019年にupdateされたPI-RADSversion2.1についても解説する．, 国内会議前立腺癌のMRI診断： Prostate Imaging?Reporting and Data System(PI-RADS) ver2.1の概要[招待有り]口頭発表（招待・特別）
- 第26回日本CT検診学会学術集会, 2019年02月, 日本語, 日本CT検診学会, 日立, 国内会議肺結節自動容積測定（Computer-Aided Volumetry）によるConvolutional Neural Networkの有用性に関する検討口頭発表（一般）
- 31st Annual Meeting of European Congress of Radiology (ECR 2019), 2019年02月, 英語, European Society of Radioogy, ウィーン, 国際会議Comparison of Capability for Nodule Component Measurement and Management on Follow-Up CT Examinations between 3D CADv Systems with and without CNN.口頭発表（一般）
- 104th Radiological Society of North America, Scientific Assembly and Annual Meeting, 2018年11月, 英語, Chicago, 国際会議Utility of Extracellular Volume Fraction Measured from Multiphasic Contrast-Enhanced Computed Tomography for the Estimation of Pancreatic Fibrosis口頭発表（一般）
- The 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America., 2018年11月, 英語, Radiological Society of North America., Chicago, 国際会議New and Updated Topics in Targeted Therapies for the Treatment of Advanced and Metastatic Renal Cell Carcinoma: What Radiologists Should Know口頭発表（一般）
- 第58回日本核医学会学術総会, 2018年11月, 英語, 日本核医学会, 宜野湾, 国内会議FDG PET/MRにおける呼吸同期下MR吸収補正と画像再構成法の影響口頭発表（一般）
- 第54回日本医学放射線学会秋季臨床大会（第31回頭頸部放射線研究会）, 2018年10月, 日本語, 村山 貞之, 福岡市, 国内会議翼口蓋窩に生じた筋上皮腫の1例口頭発表（一般）
- 第19回JSAWI, 2018年09月, 日本語, 淡路, 国内会議妊娠を契機に発見され、MRIにて術前診断された卵巣線維腫症の一例ポスター発表
- 第6回 泌尿器画像診断・治療技術研究会, 2018年09月, 日本語, 泌尿器画像診断・治療技術研究会, 京都, 国内会議腎腫瘍のPET: 画像と病理所見との対比ポスター発表
- 第51回兵庫県磁気共鳴医学研究会, 2018年07月, 日本語, 兵庫県磁気共鳴医学研究会, 神戸, 国内会議Retinal Vasculopathy with Cerebral leukoencephalopathy (RVCL) の一例口頭発表（一般）
- 第319回日本医学放射線学会関西地方会, 2018年06月, 日本語, 大阪, 国内会議線維軟骨塞栓症が疑われた若年者脊髄梗塞の一例口頭発表（一般）
- 第32回日本腹部放射線学会, 2018年05月, 日本語, 鎌倉, 国内会議術前診断が困難であった副腎血管肉腫の1例口頭発表（一般）
- 第55回関西GUR研究会, 2018年04月, 日本語, 大阪, 国内会議癒着胎盤のMRI[招待有り]口頭発表（招待・特別）
- 第77回日本医学放射線学会総会, 2018年04月, 日本語, 横浜, 国内会議Clinical and imaging features of gestational trophoblastic disease 絨毛性疾患：その臨床的特徴と画像所見[招待有り]口頭発表（招待・特別）
- The 67th Annual Meeting of CTSR, 2018年03月, 英語, Chinese Taipei Society of Radiology, 台北, 台湾, 国際会議Multiparametric Prostate MRI using PIRADS version2[招待有り]口頭発表（招待・特別）
- 第390回日本医学放射線学会関西地方会, 2018年02月, 日本語, 日本医学放射線学会, 大阪, 国内会議子宮広間膜に発生した平滑筋肉腫の一例口頭発表（一般）
- 第103回北米放射線学会, 2017年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Comparison of Integrated 18F-FDG PET/MRI Without Contrast Agents and Dynamic Contrast-enhanced MRI in Evaluating FIGO Stage in Uterine Cancer: A Preliminary Studyポスター発表
- 第57回日本核医学会総会, 2017年10月, 英語, 日本核医学会, 横浜, 【目的】PET/MR一体型装置を用いて消化管の生理的なFDG集積を評価し，MRI信号との関連を検討する【方法】消化管疾患を伴わない80例を対象に後方視的に検討した．PET収集とともに，全身MRIの横断像撮像を行った．消化管は手動で抽出され，次に2 point DIXON法の脂肪画像上で閾値を用い消化管周囲の脂肪織を除外した．得られた関心領域は複写され，閾値を用いて，T1 /T2強調画像での信号の組み合わせから4領域に分割した．各関心領域は同時収集されたPET画像上に複写され，平均SUVを測定した． 【結果】T1/T2強調画像で高/低信号を呈する領域で，下行結腸の集積(1.0±0.3)が上部消化管と比して有意に低値であった(p<0.0001)． T1/T2強調画像で低/高信号を呈する領域では，回腸の集積(2.2±0.6)が他と比して有意に高値であった(, 国内会議F-18 FDG PET/MRを用いた消化管の生理的集積に関する検討：FDG集積とMRI信号との対比口頭発表（一般）
- 73rd Korean Congress of Radiology, 2017年10月, 英語, Korean Society of Radiology, ソウル, 韓国, 国際会議Computed diffusion-weighted MRI in prostate cancer[招待有り]口頭発表（招待・特別）
- The 18th annual symposium of Japanese Society for the Advancement of Women's Imaging, 2017年09月, 日本語, Japanese Society for the Advancement of Women's Imaging, 兵庫, 国内会議子宮発生腺肉腫の 1例：術前 PETMRI画像と病理標本との対比ポスター発表
- 第45回日本磁気共鳴医学会大会, 2017年09月, 日本語, 日本磁気共鳴学会, 栃木, 国内会議PI-RADS version2を用いた前立腺癌のMRI診断[招待有り]口頭発表（招待・特別）
- 第2回Advanced Medical Imaging研究会, 2017年07月, 日本語, Advanced Medical Imaging研究会, 大阪, 国内会議各領域の進歩 婦人科[招待有り]口頭発表（招待・特別）
- 第50回核医学会近畿地方会, 2017年07月, 日本語, 日本核医学会, 大阪, 症例は50代女性。2010年頃から長径4cm大の子宮腫瘤を指摘されていたが、子宮筋腫が疑われたため経過観察されていた。2017年1月、エコーで長径12cmと増大を認め、当院産婦人科紹介となった。MRIでは、子宮体部前壁筋層内に、境界明瞭な類円形の腫瘤がみられ、左側の子宮内膜には T2強調画像でやや低信号を示し、相対的に造影効果の乏しい領域を認めた。子宮内膜の組織診を行ったところ、陰性であった。術前精査のため、PET/MRを施行したところ、子宮体部前壁筋層内の境界明瞭な類円形の腫瘤の造影効果のある大部分、及び子宮内膜左側に、限局したFDG集積を認めた。子宮内膜病変が悪性であれば、骨盤内リンパ節郭清が必要となるため、術中迅速病理でリンパ節郭清を追加するかどうかを判断する方針となり、単純子宮全摘出術及び両側付属器摘出術を施行した。術中迅速診断で子宮内膜に癌, 国内会議PET-MRIが有用であった平滑筋肉腫合併子宮体癌の1例口頭発表（一般）
- 第31回日本腹部放射線学会, 2017年05月, 日本語, 日本腹部放射線学会, 旭川, 国内会議精索原発の炎症性偽腫瘍の一例ポスター発表
- ISMRM 2017 annual Meeting, 2017年04月, 英語, International Society for Magnetic Resonance in Medicine, Honolulu, USA, Hybrid PET/MRI scanner is an emerging modality and utilized not only for oncological or neurological purposes but also for assessment of musculoskeletal disease. Simultaneous acquisition of PET and MRI enables precise anatomical localization of PET trace, 国際会議Whole body FDG PET/MR for assessment of facet joint osteoarthritis: Direct comparison of FDG uptake with MR and CT featuresポスター発表
- 第76回日本医学放射線科学会総会, 2017年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議Multiparametric Prostate MRI - Before and After Treatment[招待有り]口頭発表（招待・特別）
- European Congress of Radiology, 2017年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Minimum-phase renal dynamic CT for the comprehensive preoperative assessment of robotic partial nephrectomy using 3rd generation dual-source dual-energy CTポスター発表
- European Congress of Radiology, 2017年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Is nephrographic phase essential in multi-phasic renal dynamic contrast enhanced dual-energy CT? Usefulness of low-keV mononergetic images for excretory phaseポスター発表
- 第102回北米放射線学会, 2016年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Volumetric MRI texture analysis for assessment of lymphovascular space invasion, deep myometrium invasion and tumor grade of endometrial cancer: A preliminary study[招待有り]口頭発表（招待・特別）
- Radiological Society of North America, 2016年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Pitfalls to Avoid in Acquiring and Interpreting Prostate MRI: Seven Preconceptionsポスター発表
- 第102回北米放射線学会, 2016年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議MRI-based texture model for preoperative risk stratification in patients with endometrial carcinomaポスター発表
- Radiological Society of North America, 2016年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Congenital Cystic Lesions of the Genital Tract and Urethra: Embryologic and Anatomic Considerations, Differential Diagnosisポスター発表
- 第102回北米放射線学会, 2016年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Comparison of FDG PET Metabolic Tumor Volume versus ADC Histogram: Prognostic Value of Tumor Treatment Response and Survival in Patients with Locally Advanced Uterine Cervical Cancer[招待有り]口頭発表（招待・特別）
- 第314回日本医学放射線学会関西地方会, 2016年11月, 日本語, 日本医学放射線学会, 大阪, 国内会議腎腫瘤と肺嚢胞を認め、Birt-Hogg-Dubé (BHD)症候群と遺伝子診断された2例口頭発表（一般）
- 第75回日本医学放射線学会学術集会, 2016年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議Model-Based IR法を用いた低線量腹部CT：Hybrid IR法及びFBP法との比較口頭発表（一般）
- Annual Meeting of European Congress of Radiology 2016, 2016年03月, 英語, European Congress of Radiology, Vienna, Austria, 国際会議Newly Developed Model-Based Iterative Reconstruction Technique for Radiation Dose Reduction on Abdominal CT: Comparison of Image Quality Assessment with Hybrid Iterative Reconstruction and Filtered Back Projection Techniques in Body Phantom Study.ポスター発表
- The annual meeting of the European Society of Radiology 2016, 2016年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Model-Based iterative reconstruction technique for low radiation dose abdominal CT: comparison with hybrid iterative reconstruction and filtered back projection techniques口頭発表（一般）
- The annual meeting of the European Society of Radiology 2016, 2016年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Histogram analysis with High-resolution diffusion-weighted imaging for diagnosis of endometrial cancer: A preliminary studyポスター発表
- 101st Scientific Assembly and Annual Meeting of Radiological Society of North America/ RSNA 2015, 2015年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Newly Developed Model-Based Iterative Reconstruction Technique for Radiation Dose Reduction on Abdominal CT: Comparison of Image Quality Assessment with Hybrid Iterative Reconstruction and Filtered Back Projection Techniques in Body Phantom Studyポスター発表
- The 101th Annual Meeting of Radiological Society of North America, 2015年12月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Evaluation for Reliability and Validity of Newly Developed MRI-based Radiological Scoring System for Invasive Placenta Previaポスター発表
- 101st Annual Meeting of Radiological Society of North America, 2015年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Newly Developed Model-Based Iterative Reconstruction Technique for Radiation Dose Reduction on Abdominal CT: Comparison of Image Quality Assessment with Hybrid Iterative Reconstruction and Filtered Back Projection Techniques in Body Phantom Study.口頭発表（一般）
- Japanese Meeting in ISMRM 2015, 2015年06月, 日本語, Guerbet Japan, Tronto, Canada, 国内会議ISMRM2015 トピックス 骨盤公開講演，セミナー，チュートリアル，講習，講義等
- The 24st Annual Meeting of International Society for Magnetic Resonance in Medicine, 2015年06月, 英語, International Society for Magnetic Resonance in Medicine, Tronto, Canada, 国際会議High resolution computed DWI with high b-value for prostate cancer: a preliminary studyポスター発表
- 23rd Annual Meeting and Exhibition of ISMRM/ ISMRM 2015, 2015年05月, 英語, International Society of Magnetic Resonance in Medicine, Toronto, Canada, 国際会議Pulmonary Thin-Section 3D MR Imaging with Ultra-Short TE: Comparison of Capability for Radiological Findings Assessment with Thin-Section CT口頭発表（一般）
- 23rd Annual Meeting and Exhibition of ISMRM/ ISMRM 2015, 2015年05月, 英語, International Society of Magnetic Resonance in Medicine, Toronto, Canada, 国際会議Diffusion-Weighted MRI (DWI) with Fast Advanced Spin-Echo Sequence: Comparison of N-Stage Assessment with DWI with Echo-Planar Imaging and FDG-PET/CT in Non-Small Cell Lung Cancer Patients口頭発表（一般）
- 23rd Annual Meeting and Exhibition of ISMRM/ ISMRM 2015, 2015年05月, 英語, International Society of Magnetic Resonance in Medicine, Toronto, Canada, 国際会議Chemical Exchange Saturation Transfer (CEST) Imaging for Thoracic Oncology: Preliminary Experience for Characterization of Thoracic Nodule and Mass口頭発表（一般）
- ECR 2015, 2015年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議Multiparametric 3-Tesla MRI using a phased-array coil for preoperative local staging of prostate cancer: utility of the 3D T2-weighted sequenceポスター発表
- The annual meeting of the European Society of Radiology 2015, 2015年03月, 英語, The European Society of Radiology, ウィーン, オーストリア, 国際会議High resolution computed DWI with high b-value for prostate cancer: a preliminary study口頭発表（一般）
- The 15th Asian Oceanian Congress of Radiology, 2014年09月, 英語, The Asian Oceanian Congress of Radiology, 兵庫, 国際会議Tissue-specific Variable Refocusing Flip-angle Sequence: Improving Image Quality of 3D Turbo-Spin-Echo Imaging of Prostate at 3TMRI口頭発表（一般）
- 第42回日本磁気共鳴学会, 2014年09月, 日本語, 日本磁気共鳴学会, 京都, 国内会議Tissue-specific Variable Refocus Flip Angle： 前立腺癌患者の3D TSE T2 強調像 における有用性の検討口頭発表（一般）
- The 16th Japanese Society for the Advancement of Women's Imaging, 2014年08月, 日本語, TheJapanese Society for the Advancement of Women's Imaging, 兵庫, 国内会議母体血清AFP上昇を伴ったBreus Moleの1例ポスター発表
- 第28回日本腹部放射線研究会, 2014年06月, 日本語, 日本腹部放射線研究会, 秋田, 国内会議臍転移により発見された卵巣成熟嚢胞性奇形腫悪性転化の1例口頭発表（一般）
- 第4回Advanced CT・MRI研究会, 2014年06月, 日本語, Advanced CT・MRI研究会, 軽井沢, 国内会議前立腺のComputed DWI[招待有り]口頭発表（招待・特別）
- 第28回日本腹部放射線学会, 2014年06月, 英語, 第28回日本腹部放射線学会, 秋田, 国内会議Two cases of ovarian sclerosing stromal tumor with imaging-pathological correlation口頭発表（一般）
- The 22st Annual Meeting of International Society for Magnetic Resonance in Medicine, 2014年05月, 英語, The International Society for Magnetic Resonance in Medicine, ミラノ, イタリア, 国際会議Designing Tissue-specific Variable Flip Angle for Improved 3D Turbo-Spin-Echo Imaging of the Prostate at 3T MRI.ポスター発表
- 第73回 日本医学放射線学会総会, 2014年04月, 英語, 日本医学放射線学会, 横浜, 国内会議Computed Diffusion-Weighted MR Imaging for Prostate Cancer Detection: Determination of Optimal b-Value Combinations for Generating High b-Value Images.口頭発表（一般）
- The 2nd International Congress on Magnetic Resonance Imaging& The 19th Annual Scientific Meeting of KSMRM, 2014年03月, 英語, Korean Society for Magnetic Resonance in Medicine, Seoul, Korea, 計算拡散強調画像の、前立腺癌検出における元画像の最適b値の検討, 国際会議Which b-Value Combination is the Best for Prostatic Cancer Detection on cDWI with High b-Value as compared with Actual DWI with High b-Value?ポスター発表
- European Congress of Radiology 2015, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, Austria, 国際会議The visualization of periprostatic nerve fibers using Diffusion Tensor Magnetic Resonance Imaging with tractographyポスター発表
- European Congress of Radiology, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, 国際会議The influence of temporal resolution and type of arterial input function in evaluating pharmacokinetic parameters of the prostate dynamic contrast enhanced MRIポスター発表
- The annual meeting of the European Society of Radiology 2014, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, 計算拡散強調画像の、前立腺癌検出における元画像の最適b値の検討, 国際会議Computed diffusion-weighted MR imaging for quantitative prostate cancer diagnosis: determination of optimal b-value combinations for generating high b-value imagesポスター発表
- The annual meeting of the European Society of Radiology 2014, 2014年03月, 英語, European Society of Radiology, Vienna, Austria, 拡大拡散強調画像の有用性の検討, 国際会議Clinical impact of zoomed echo planar imaging: improving image quality of diffusion-weighted imaging of uterus at 3T-MRIポスター発表
- The 100th Annual Meeting of Radiological Society of North America, 2013年12月, 英語, Radiological Society of North America, Chicago, USA, 計算拡散強調画像の、前立腺癌検出における元画像の最適b値の検討, 国際会議Computed Diffusion-Weighted MR Imaging for Prostate Cancer Detection: Which Combination of b-Values is Appropriate for Generating Ultra-High b-Value Images?口頭発表（一般）
- The 99th Annual Meeting of Radiological Society of North America, 2013年12月, 英語, Radiological Society of North America, Chicago, USA, 癒着胎盤の診断に有用なMRI画像所見の検討, 国際会議Brand-new MRI Finding as Predictor of Placental Invasion: Evaluation of 64 Patients with Clinical and Histopathological Correlation口頭発表（一般）
- Korean Congress of Radiology,, 2013年10月, 英語, Korean Society of Radiology, Seoul, Korea, 国際会議Prostate diffusion weighted imaging update[招待有り]口頭発表（招待・特別）
- Korean Congress of Radiology,, 2013年10月, 英語, Korean Society of Radiology, Seoul, Korea, 国際会議Current role of CT for small renal tumor[招待有り]口頭発表（招待・特別）
- 第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 前立腺癌の病期分類における教育講演。, 国内会議前立腺癌の病期分類口頭発表（基調）
- 第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 国内会議Zoom DTI を用いたFiber Tractographyによる前立腺神経血管束の描出ポスター発表
- 第41回日本磁気共鳴医学会大会, 2013年09月, 日本語, 日本磁気共鳴医学会, 徳島, 計算拡散強調画像の、前立腺癌検出における元画像の最適b値の検討, 国内会議Ultra-High b-Value Computed Diffusion Weighted Images： 前立腺癌検出における元画像の最適b値の検討口頭発表（一般）
- 第9回JSAWI, 2013年09月, 日本語, 日本女性画像診断研究会, 淡路島, 国内会議PET-MRI fusion画像を用いた婦人科癌の画像診断の試みポスター発表
- 第27回腹部放射線研究会, 2013年06月, 日本語, 日本腹部放射線学会, 宇都宮, 国内会議Birt-Hogg-Dube症候群に見られた多発腎腫瘍の1例口頭発表（一般）
- 第27回日本腹部放射線学会, 2013年05月, 日本語, 日本腹部放射線学会, 宇都宮, 国内会議前立腺領域のMRI最先端公開講演，セミナー，チュートリアル，講習，講義等
- The 21st Annual Meeting of International Society for Magnetic Resonance in Medicine, 2013年05月, 英語, International Society for Magnetic Resonance in Medicine, Salt Lake City, USA, 前立腺癌の検出における計算拡散強調画像の有用性を検討した。, 国際会議Computed High b-value DWI for Detection of Prostatic Cancer at 3-Tesla MRIポスター発表
- International Society for Magnetic Resonance in Medicine,, 2013年04月, 英語, International Society for Magnetic Resonance in Medicine,, Salt lake, USA, 国際会議Tractography of the neurovascular bundles of the prostate with "zoom DTI" technique: preliminary report.ポスター発表
- 第72回日本医学放射線学会学術集会, 2013年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議Computed high b-value DWIの前立腺癌検出に関する有用性の検討口頭発表（一般）
- 第72回日本医学放射線学会総会, 2013年04月, 英語, 日本医学放射線学会, 横浜, 前立腺癌の検出における計算拡散強調画像の有用性を検討した。, 国際会議Computed Diffusion-Weighted MRI for the Prostate Cancer Detection at 3-T MRI: evaluation in 80 cases with histopathological correlation口頭発表（一般）
- 第4回Asian congress abdominal radiology, 2013年03月, 英語, アジア腹部放射線研究会, Kaohsiungm, Taiwan, Computed DWI (cDWI) calculated with a combination of lower b-value images potentially suppressed background noise maintaining lesion signal, leading to better contrast of cancerous lesion. The purpose of the study was to evaluate the ability of cDWI by comparing with measured original DWI of b=1000 (mDWI1000) and 2000 (mDWI2000) at 3-Tesla MRI for cancer detection using histopa, 国際会議Computed diffusion weighted imaging for the detection of prostate cancer at 3-tesla MRI口頭発表（一般）
- 第4回Asian congress abdominal radiology, 2013年03月, 英語, アジア腹部放射線研究会, Kaohsiungm, Taiwan, We investigated the usefulness of apparent diffusion coefficient (ADC) values in predicting true Gleason scores from radical prostatectomy specimen (tGS), compared with systematic transrectal ultrasound (TRUS)-guided biopsy GS (bGS)., 国際会議Can Apparent Diffusion Coefficient (ADC) values be obtained using high b-values with a 3-Tesla MRI correlate better withtrue Gleason Scores from radical prostatectomy specimen than a transrectal ultrasound (TRUS)-guided biopsy in patients with prostate ca口頭発表（一般）
- ECR 2013, 2013年03月, 英語, European society of radiology, Vienna, Austria, 国際会議Arterial spin labelling for the prostate: Initial experience at 3T MRI.口頭発表（一般）
- ASAR2013, 2013年03月, 英語, Asian Abdominal Society of Radiology, Kaohsiung, Taiwan, 国際会議Arterial spin labeling for the prostate Initial experience at 3T MRI口頭発表（一般）
- 第4回Asian congress abdominal radiology, 2013年03月, 英語, アジア腹部放射線研究会, Kaohsiungm, Taiwan, We evaluated arterail spin labelling of prostate cancer., 国際会議Arterial spin labeling for the prostate: Initial experience at 3T MRI口頭発表（一般）
- European congress radiology, 2013年03月, 英語, ヨーロッパ放射線学会, Vienna, Austria, We evaluated arterail spin labelling of prostate cancer., 国際会議Arterial spin labeling for the prostate: Initial experience at 3T MRI口頭発表（一般）
- RSNA 2012, 2012年11月, 英語, Radiological Society of North America, Chicago, USA, 国際会議Computed Diffusion Weighted Imaging for the Detection of Prostate Cancer with 3-Tesla MRI口頭発表（一般）
- 32nd Congress of the Société Internationale d'Urologie,, 2012年10月, 英語, Société Internationale d'Urologie, Fukuoka, Japan, 国内会議Advances in Imaging for the Prostate: Current Role of PET & CT/MRI for Defining Progression[招待有り]シンポジウム・ワークショップパネル（指名）
- 32nd Congress of the Société Internationale d'Urologie,, 2012年10月, 英語, Société Internationale d'Urologie, Fukuoka, Japan, 国内会議Advances in Imaging for the Prostate: Advances in MRI[招待有り]シンポジウム・ワークショップパネル（指名）
- 第8回JSAWI, 2012年09月, 日本語, 日本女性医学会, 淡路, 癒着胎盤のMRIを解説, 国内会議癒着胎盤のMRIポスター発表
- 第40回日本磁気共鳴医学会大会, 2012年09月, 日本語, 日本磁気共鳴医学会, 京都, 国内会議前立腺に対するArterial spin labellingの試み口頭発表（一般）
- 第40回日本磁気共鳴医学会大会, 2012年09月, 日本語, 日本磁気共鳴学会, 京都, 3テスラMRIでの前立腺癌検出におけるcomputed DWIの有用性を検討, 国内会議3テスラMRIでの前立腺癌検出におけるcomputed DWIの有用性口頭発表（一般）
- 14th Asian Oceanian Congress of Radiology, 2012年08月, 英語, Asian Oceanian Congress of Radiology, Sydney, Australia, We determined if ADC using ultra-high b-value (b=2,000 s/mm2) at 3T MRI is superior to standard-high b-value (b=1,000 s/mm2) for differentiation between malignant and noncancerous tissues in prostate, using histopathological findings of radical prostatectomy as a reference standard, 国際会議Differentiation of malignant and normal tissues of the prostate by apparent diffusion coefficient values at 3-Tesla MRI: Comparison between ultra-high b-value (2,000 s/mm2) and standard-high b-value (1,000 s/mm2)口頭発表（一般）
- AOCR2012, 2012年08月, 英語, Asia oceania society of radioogy, Sydney, Australia, 国際会議3D-T2-weighted MRI for the prostate cancer at 3T with interactive multiplanar reformat imaging口頭発表（一般）
- 第71回日本医学放射線学会総会, 2012年04月, 日本語, 日本医学放射線学会, 横浜, 国内会議肺癌患者の全身3T MRIにおけるQuick 3D with Enhanced Fat Freeの有用性に関する検討口頭発表（一般）
- 第71回日本医学放射線学会総会, 2012年04月, 日本語, 日本医学放射線学会, 横浜, 前立腺癌検出におけるcomputed DWIの有用性を検討, 国内会議前立腺癌検出におけるcomputed DWIの有用性：初期報告口頭発表（一般）
- 第71回日本医学放射線学会総会, 2012年04月, 日本語, 日本医学放射線学会, 横浜, 3テスラMRI装置での拡散強調画像における、視覚的な前立腺癌検出能に与えるb値の影響を検討, 国内会議3テスラMRI装置での拡散強調画像における、視覚的な前立腺癌検出能に与えるb値の影響口頭発表（一般）
- 2012年欧州放射線学会, 2012年03月, 英語, 欧州放射線学会, ウィーン, オーストリア, 国際会議Volumetric 3D-T2-weighted MRI for the prostate cancer at 3T with interactive multiplanar reformat imaging: Are there any additional values over 2D-T2-weighted images?ポスター発表
- 欧州放射線学会議, 2012年03月, 英語, 欧州放射線学会, ウイーン, オーストリア, 国際会議Low-dose non-enhanced CT versus full-dose contrast-enhanced CT in integrated FDG PET/CT studies for the diagnosis of ovarian cancer recurrence口頭発表（一般）
- 欧州放射線学会議, 2012年03月, 英語, 欧州放射線学会, ウイーン, オーストリア, 国際会議FDG-PET/CT and uterine cancerポスター発表
- 第97回北米放射線学会, 2011年11月, 英語, 北米放射線学会, シカゴ, アメリカ, 国際会議Dark Focus is not always evil: Characterization of the prostate disorders showing low signal on T2-weighted MR imagesポスター発表
- 第7回泌尿器腫瘍放射線研究会, 2011年10月, 日本語, 泌尿器腫瘍放射線研究会, 名古屋, 国内会議前立腺癌検出における3テスラMRI装置の拡散強調画像の至適high b値の検討口頭発表（一般）
- 第18回欧州泌尿器放射線学会, 2011年10月, 英語, 欧州泌尿器放射線学会, ドブロニク, クロアチア, 国際会議What urologists wish to know beyond differential diagnosis and staging in preoperative evaluation of laparoscopic surgery for urogenital malignancies.ポスター発表
- 第18回欧州泌尿器放射線学会, 2011年10月, 英語, 欧州泌尿器放射線学会, ドブロニク, クロアチア, 国際会議Volumetric 3D-T2-weighted MRI for the prostate cancer at 3T with interactive multiplanar reformat imaging: Are there any additional values over 2D-T2-weighted images?口頭発表（一般）
- 第47回日本医学放射線学会秋季臨床大会, 2011年10月, 日本語, 日本医学放射線学会, 下関, 国内会議FDG集積をきたした卵巣Leydig cell tumorの一例ポスター発表
- 第7回泌尿器科腫瘍放射線（GUTR)研究会, 2011年10月, 日本語, 泌尿器科腫瘍放射線（GUTR)研究会, 名古屋, 国内会議3テスラMRI装置での拡散強調画像における,視覚的な前立腺癌検出能に与えるb値の影響口頭発表（一般）
- 第7回JSAWI, 2011年09月, 日本語, 日本医学放射線学会、日本医学産婦人科学会、日本医学病理学会, 淡路, 国内会議胎盤血管腫の1例ポスター発表
- 第39回日本磁気共鳴医学会大会, 2011年09月, 日本語, 日本磁気共鳴医学会, 小倉, 国内会議前立腺癌検出における3テスラMRI装置の拡散強調画像の至適high b値の検討口頭発表（一般）
- 第7回JSAWI, 2011年09月, 日本語, 日本医学放射線学会、日本医学産婦人科学会、日本医学病理学会, 淡路, 国内会議FDG-PET/CTによる卵巣腫瘍の良悪の鑑別診断ポスター発表
- 第39回日本磁気共鳴医学会大会, 2011年09月, 日本語, 日本磁気共鳴医学会, 小倉, 国内会議3T MRI装置でのUltra high b value（b=2000s/mm2）によるADC値を用いた前立腺癌検出能の検討：b=1000との比較口頭発表（一般）
- 第39回日本磁気共鳴医学会大会, 2011年09月, 日本語, 日本磁気共鳴医学会, 北九州, 国内会議3Tesla Large bore MR装置を用いた体位による腎移動の可視化口頭発表（一般）
- 第44回日本核医学近畿地方会, 2011年07月, 日本語, 日本核医学会, 神戸, 国内会議FDG集積を来たした卵巣Leydig cell tumorの一例口頭発表（一般）
- 第298回日本医学放射線学会関西地方会, 2011年06月, 日本語, 日本医学放射線学会, 大阪, 国内会議非典型的なMRI像を呈した卵巣粘液性嚢胞腺癌の1例口頭発表（一般）
- 第44回兵庫磁気共鳴医学研究会, 2011年06月, 日本語, 兵庫磁気共鳴医学研究会, 神戸, 国内会議前置血管の1例口頭発表（一般）
- 第3回アジア腹部放射線研究会, 2011年05月, 英語, アジア腹部放射線研究会, 北京, 中国, 国際会議Real-time virtual sonography for navigation during targeted prostate biopsy using magnetic resonance imaging dataポスター発表
- 第3回アジア腹部放射線研究会, 2011年05月, 英語, アジア腹部放射線研究会, 北京, 中国, 国際会議Differentiation of prostate malignant and normal peripheral tissues by ADC at 3-T MRI: Comparison between b=2,000 and 1,000 s/mm2口頭発表（一般）
■ 共同研究・競争的資金等の研究課題
- 日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2022年04月01日 - 2025年03月31日人工知能を用いた膵癌CT自動診断システム開発とスクリーニング・早期診断への応用腹部造影CT画像に対して画像AI技術を用い、膵腫瘤および膵癌に付随する頻度の高い二次所見（主膵管拡張、主膵管狭窄、膵萎縮）の自動検出による膵癌自動診断システムの構築を試みた。深層学習を用いて、膵実質、膵管、腫瘤の各領域を自動抽出し、抽出結果に基づき膵腫瘤性病変ならびに二次所見の有無を判定可能なAIエンジンを構築した。トレーニングセット・バリデーションセットとして膵癌群587例、対照群432例を用い、テストデータとして関連施設より収集した膵癌群62例、対照群90症例を対象に、膵腫瘤検出AI単独による膵癌検出精度ならびに膵腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出精度を評価・算出した。 テストデータにおける腫瘤検出AIのみによる膵癌検出能は、感度73.3%、特異度96.7%であった。腫瘤検出AIと二次所見検出AIの組合せによる膵癌検出能は、感度93.5%、特異度84.4%であった。二次所見検出AIを組み合わせることにより検出感度が向上するとともに、腫瘤検出AI単独では検出できなかったTisやT1等の小膵癌に対しても検出成功例が増加した。
- 日本学術振興会, 科学研究費助成事業 若手研究, 若手研究, 神戸大学, 2021年04月01日 - 2025年03月31日高空間・高時間分解能ダイナミックMRIによる新しい膀胱癌深達度診断法の開発今年度は4D-FB法を用いた高空間・高時間分解能iso-voxel 3DダイナミックMRI（DCE-MRI）の至適撮像プロトコールの決定を目標とした。まず膀胱より撮像範囲が小さく安定した画質を得やすい前立腺領域において4D-FBダイナミックMRIの撮像を行い、Footprint値や撮像方向、バンド幅が画質に影響を与えることを明らかにした。 さらに前立腺癌の評価において、従来法のe-THRIVE DCE-MRIと4D-FB DCE-MRIにおける診断能の違い、画質の違いを評価検討した。研究法は以下の通りである。 症例数(各群n=12)、年齢、初回PSA、highest Gleason scoreをマッチさせた群において、4D-FB法とe-THRIVE法による各DCE-MRIで定量項目Ktrans, Kep, Veを算出し、これらによる前立腺有意癌の検出能をareas by the receiver operating characteristic curve (AUC)で評価した。画質評価として各DCE-MRIで癌と非癌部における信号強度比（SNR）、放射線診断専門医による視覚評価を行い、Mann Whitney testで各項目の比較を行った。いずれも病理標本結果をリファレンススタンダードとした。結果、各DCE-MRIのAUCに有意差は得られなかった（P>0.05）。SNRはいずれの部位でも4D-FB法が有意に高く(癌部P<0.001, 非癌部P<0.001)、視覚評価においても4D-FB法が優れていた。本研究により4D-FB DCE-MRIが前立腺癌診断能を担保したまま、従来法よりも高い画質の取得に有用である可能性が示唆された。この結果は2021年度の国際MRI学会で報告した。
- 日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月 - 2022年03月ヨードマップを用いた膵癌の線維性間質定量による悪性度および治療抵抗性の予測法確立
- 学術研究助成基金助成金／若手研究(B), 2014年04月 - 2016年03月, 研究代表者競争的資金