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星 奈美子
大学院医学研究科 医科学専攻
准教授

研究者基本情報

■ 学位
  • 博士（医学）, 福島県立医科大学
■ 研究分野
  • ライフサイエンス / 消化器内科学
■ 委員歴
  • 2024年12月 - 現在, アジア炎症性腸疾患学会総会, 第13回AOCC総会 プログラム委員
  • 2024年11月 - 現在, 日本消化器病学会, 炎症性腸疾患（IBD)ガイドライン作成委員
  • 2023年 - 現在, 日本炎症性腸疾患学会学術集会, プログラム委員
  • 2023年 - 現在, 日本医学会連合による領域横断的連携活動事業 多学会連携による慢性疾患患者の挙児希望を叶えるための横断的指針作成, ワーキンググループ委員
  • 2019年04月 - 現在, 難治性炎症性腸管障害に関する調査研究, 研究協力者
  • 2017年 - 現在, 日本炎症性腸疾患学会, 国際交流委員
  • - 現在, 日本炎症性腸疾患学会, 代議員
  • 日本炎症性腸疾患学会, 研究助成委員
  • 日本消化器病学会, 評議員

研究活動情報

■ 受賞
  • 2023年 日本消化器病学会, 日本消化器病学会女性研究者賞

  • 2013年11月 The American Gastroenterological Association, The JUCC Award of the 7th JUCC, Cell type-specific role of MyD88 in commensal-dependent colitis
    NamikoHoshi
    国際学会・会議・シンポジウム等の賞

■ 論文
  • Yunlong Sui, Namiko Hoshi, Norihiro Okamoto, Yuta Inoue, Takumi Funatsu, Yuna Ku, Makoto Ooi, Daisuke Watanabe, Haruka Miyazaki, Misaki Agawa, Hirotaka Nakamura, Ryuichi Ohgaki, Yoshikatsu Kanai, Hui Yang, Yuzo Kodama
    Elsevier BV, 2025年02月, Biochemical and Biophysical Research Communications, 151446 - 151446
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Makoto Okabe, Shuji Yamamoto, Masahiro Shiokawa, Tadakazu Hisamatsu, Hajime Yamazaki, Risa Nakanishi, Kensuke Hamada, Hiroki Kitamoto, Takeshi Kuwada, Norimitsu Uza, Aki Sakatani, Toshimitsu Fujii, Masashi Ohno, Minoru Matsuura, Tomoyoshi Shibuya, Naoki Ohmiya, Makoto Ooi, Namiko Hoshi, Kei Moriya, Kiichiro Tsuchiya, Yoshiharu Yamaguchi, Reiko Kunisaki, Masahiro Takahara, Tomohisa Takagi, Tetsuo Takehara, Fumihito Hirai, Kazuki Kakimoto, Motohiro Esaki, Hiroshi Nakase, Fukunori Kinjo, Takehiro Torisu, Shuji Kanmura, Kazuyuki Narimatsu, Katsuyoshi Matsuoka, Hiroto Hiraga, Kaoru Yokoyama, Yusuke Honzawa, Makoto Naganuma, Masayuki Saruta, Yuzo Kodama, Tsutomu Chiba, Hiroshi Seno
    BACKGROUND: A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-integrin αvβ6 antibody (V6 Ab) for diagnosing UC with high sensitivity and specificity, no large-scale validation study exists. This study aimed to validate the diagnostic value of V6 Ab for UC using a nationwide multicenter cohort study. METHODS: We measured V6 Ab titers in patients definitively diagnosed with UC, Crohn's disease (CD), or other gastrointestinal disorders (OGDs). The primary outcome was the diagnostic value of V6 Ab. Secondary outcomes were factors associated with false-negative results in patients with UC and false-positive results in patients without UC and the heterogeneity of the diagnostic value of V6 Ab among the participating facilities. RESULTS: We enrolled 1241, 796, and 206 patients with UC, CD, and OGD, respectively, from 28 Japanese high-volume referral centers. The diagnostic sensitivity of V6 Ab for UC was 87.7%, and its specificities for CD and OGDs were 82.0% and 87.4%, respectively. Multivariable logistic regression analysis showed that false-negative results were associated with older age at the time of sample collection, current smokers, lower partial Mayo score, and not receiving advanced therapies in patients with UC, and false-positive results were associated with colonic CD in patients with CD. No factor was associated with false-positive results in patients with OGDs. There were no significant differences in the diagnostic value of V6 Ab among the centers. CONCLUSIONS: The diagnostic value of V6 Ab for UC was validated in the large-scale nationwide multicenter study.
    2024年11月, Journal of gastroenterology, 英語, 国内誌
    研究論文（学術雑誌）

  • Yasuyuki Shimizu, Shunta Hirano, Mohammed Salah, Namiko Hoshi, Yoko Yamashita, Takeshi Fukumoto, Naritoshi Mukumoto, Ai Nakaoka, Takeaki Ishihara, Daisuke Miyawaki, Hitoshi Ashida, Ryohei Sasaki
    BACKGROUND: Proanthocyanidins (PACs) from black soybean seed coat have antioxidant and anti-tumorigenic properties. We investigated the anti-tumor properties and mechanisms of action of PACs on colorectal cancer (CRC). METHODS: We fed the APCmin/+ mice, which are highly susceptible to spontaneous intestinal adenoma formation, diets supplemented with or without PACs for 7 weeks and assessed adverse effects, the number and size of intestinal polyps, and the expression of pro- and anti-proliferative proteins in the intestine. The mouse gut microbiome composition was analyzed, and the concentrations of gut short-chain fatty acids (SCFAs) were quantified. We also compared CRC incidence in Tamba in Japan, where black soybean is consumed frequently, with that in the rest of Japan. RESULTS: The number and size of intestinal polyps notably decreased in the PAC-fed mice. Compared with control mice, the PAC-fed mice showed lower expression of proliferation markers proliferating cell nuclear antigen and β catenin and a higher expression of the anti-inflammatory protein oligomeric mucus gel-forming. PAC supplementation increased the prevalence and concentrations of beneficial gut microbes and SCFAs, respectively. CONCLUSIONS: Diet supplemented with black soybean-derived PACs could prevent CRC development in mice through gut microbiome remodeling. Regions consuming black soybeans have low CRC incidence. Notably, the incidence of CRC, breast cancer, and liver cancer was significantly lower in Tamba than in the rest of Hyogo Prefecture or Japan. Future studies should delineate the mechanisms underlying the CRC-protective effects of PACs. Nevertheless, our results demonstrate the potential of including PACs in dietary recommendations for cancer prevention.
    2024年11月, Cancers, 16(22) (22), 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 潰瘍性大腸炎の発症時に免疫性血小板減少症を合併した1例
    今川 幸人, 堀之内 智子, 近藤 淳, 岡本 典大, 宮崎 はる香, 田中 悠, 市川 裕太, 上田 知佳, 北角 英晶, 田村 彰広, 渡邉 大輔, 山本 暢之, 榊原 菜々, 大井 充, 星 奈美子, 児玉 祐三, 野津 寛大
    (公社)日本小児科学会, 2024年04月, 日本小児科学会雑誌, 128(4) (4), 624 - 624, 日本語

  • Haruka Miyazaki, Namiko Hoshi, Tsukasa Ishida, Chiharu Nishioka, Sachiko Ouchi, Daisuke Shirasaka, Tomoo Yoshie, Yoshinori Munetomo, Yoshio Sakamoto, Tatsuya Osuga, Saori Matsui, Toshiki Hyodo, Tamami Denda, Daisuke Watanabe, Makoto Ooi, Yuzo Kodama
    Not all patients with ulcerative colitis (UC) respond initially to treatment with biologic agents, and predicting their efficacy prior to treatment is difficult. Vedolizumab, a humanized monoclonal antibody against alpha 4 beta 7 (α4β7) integrin, suppresses immune cell migration by blocking the interaction between α4β7 integrin and mucosal addressin cell adhesion molecule 1. Reports about histological features that predict vedolizumab efficacy are scarce. So, we examined the association between histological features and vedolizumab efficacy. This was a multicenter, retrospective study of patients with UC treated with vedolizumab. Biopsy specimens taken from the colonic mucosa prior to vedolizumab induction were used, and the areas positively stained for CD4, CD68, and CD45 were calculated. Clinical and histological features were compared between those with and without remission at week 22, and the factors associated with clinical outcomes were identified. We enrolled 42 patients. Patients with a high CD4+ infiltration showed a better response to vedolizumab [odds ratio (OR) = 1.44, P = 0.014]. The concomitant use of corticosteroids and high Mayo scores had a negative association with the vedolizumab response (OR = 0.11, P = 0.008 and OR = 0.50, P = 0.009, respectively). Histological evaluation for CD4+ cell infiltration may be helpful in selecting patients who can benefit from vedolizumab.
    2023年11月, Scientific reports, 13(1) (1), 20262 - 20262, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Sayaka Ikeda, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi, Yuzo Kodama
    BACKGROUND/PURPOSE OF THIS STUDY: It has been recommended that individuals with inflammatory bowel disease (IBD) be vaccinated against Coronavirus disease - 19 (COVID-19). Recently, we documented the incidence of side effects (SEs) after COVID-19 immunization among individuals with IBD in Japan. However, the study did not show differences between the types of IBD or the patients' clinical backgrounds. In this survey, we aimed at investigating whether the frequency of SEs differed among patients with IBD. METHODS: A cross-sectional survey was conducted among adult patients with IBD at Kobe University between March 2022 and September 2022. RESULTS: Total 195 patients, including 134 with ulcerative colitis (UC) and 61 with Crohn's disease (CD), completed the questionnaire and were included in the analysis. Of these, 92.3%, 91.3% and 44.1% received the initial, second and third dose of the COVID-19 vaccine, respectively. The frequency of local symptoms following the initial, second and third dose of the vaccine was comparable between patients with UC and CD (69.6% vs. 72.7%, 64.2% vs. 69.1% and 63.5% vs. 73.9%, respectively). Muscle pain after the initial and second doses of the COVID-19 vaccine was more common among patients treated with corticosteroids (58.1% vs. 37.6% and 60.0% vs. 31.8%, p < 0.05). Female sex, younger age and current or former smoking were associated with an increased incidence of fever or chills after the initial dose of the vaccine (p < 0.05). In contrast, corticosteroid use was identified as a factor associated with an increased incidence of muscle pain after the initial dose of vaccine (p < 0.05). CONCLUSION: The use of corticosteroids could increase the risk of muscle pain following COVID-19 vaccination. Additionally, factors such as female sex, younger age and current or former smoking can affect the incidence of fever or chills. This information should encourage patients with IBD to get vaccinated against COVID-19.
    2023年10月, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 42(5) (5), 701 - 707, 英語, 国際誌
    研究論文（学術雑誌）

  • Yuki Ito, Daisuke Watanabe, Sayaka Ikeda, Norihiro Okamoto, Haruka Miyazaki, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi, Yuzo Kodama
    Mycobacterium avium complex (MAC) is an important cause of opportunistic infections in immunosuppressed hosts, such as patients with HIV infection and solid organ transplant recipients. MAC disease usually presents in 4 distinct clinical categories: chronic pulmonary disease, disseminated disease, skin/soft-tissue infection, and superficial lymphadenitis. However, clinical reports on gastrointestinal (GI) MAC disease are rare, especially in patients without HIV infection or a history of organ transplantation. We describe a case of non-HIV-associated GI MAC disease in a patient with long-term mycophenolate mofetil use. In this case, MAC organisms in the GI tract and ascites were observed. Endoscopy revealed a unique colonic image with large, deep epithelial denudations. This suggests that apart from patients with HIV infection or transplant recipients, those treated with immunosuppressants can have disseminated MAC. Therefore, internal physicians need to monitor patients undergoing mycophenolate mofetil immunosuppressant therapy.
    2023年04月, ACG case reports journal, 10(4) (4), e01033, 英語, 国際誌

  • 近藤 淳, 堀之内 智子, 岡本 典大, 吉村 翔平, 市川 裕太, 田中 悠, 上田 知佳, 北角 英晶, 榊原 菜々, 渡邊 大輔, 星 奈美子, 大片 祐一, 大井 充, 尾藤 祐子, 児玉 裕三, 野津 寛大
    (一社)日本小児栄養消化器肝臓学会, 2023年04月, 日本小児栄養消化器肝臓学会雑誌, 37(1) (1), 35 - 35, 日本語

  • 一過性の細胞免疫不全所見を認めた超早期発症型炎症性腸疾患の1例
    福田 拓弥, 堀之内 智子, 近藤 淳, 宮崎 はる香, 田村 彰広, 大片 祐一, 増田 知佳, 北角 英晶, 具 潤亜, 渡邉 大輔, 星 奈美子, 榊原 菜々, 山本 暢之, 大井 充, 尾藤 祐子, 森 一越, 野津 寛大
    (公社)日本小児科学会, 2023年04月, 日本小児科学会雑誌, 127(4) (4), 625 - 626, 日本語

  • Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Lingling Kong, Ryutaro Yoshida, Norihiro Okamoto, Masato Kinoshita, Haruka Miyazaki, Yuna Ku, Eri Tokunaga, Yuki Ito, Daisuke Watanabe, Makoto Ooi, Masakazu Shinohara, Kengo Sasaki, Yoh Zen, Takenori Kotani, Takashi Matozaki, Zibin Tian, Yoshikatsu Kanai, Yuzo Kodama
    Abstract Background Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood. Methods To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an ApcMin/+ background (LAT1fl/fl; vil-cre; ApcMin/+), which were subject to analysis; organoids derived from those mice were also analyzed. Results This study showed that LAT1 was constitutively expressed in normal crypt base cells, and its conditional deletion in the intestinal epithelium resulted in fewer Paneth cells. LAT1 deletion reduced tumor size and number in the small intestine of ApcMin/+ mice. Organoids derived from LAT1-deleted ApcMin/+ intestinal crypts displayed fewer spherical organoids with reduced Wnt/β-catenin target gene expression, suggesting a low tumor-initiation capacity. Wnt3 expression was decreased in the absence of LAT1 in the intestinal epithelium, suggesting that loss of Paneth cells due to LAT1 deficiency reduced the risk of tumor initiation by decreasing Wnt3 production. Conclusions LAT1 affects intestinal tumor development in a cell-extrinsic manner through reduced Wnt3 expression in Paneth cells. Our findings may partly explain how nutrient availability can affect the risk of tumor development in the intestines.
    Springer Science and Business Media LLC, 2023年02月, Journal of Gastroenterology
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Haruka Miyazaki, Daisuke Watanabe, Yuki Ito, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Makoto Ooi, Namiko Hoshi, Yuzo Kodama
    BACKGROUND: Patients with inflammatory bowel disease (IBD) are recommended to receive the coronavirus disease 2019 (COVID-19) vaccine. However, a recent survey showed that patients with IBD are more hesitant to receive the vaccine than the general population. Detailed information on the side effects of the COVID-19 vaccine is necessary to encourage vaccination among patients with IBD. AIM: To investigate the frequency of side effects following COVID-19 vaccination in patients with IBD in Japan. STUDY DESIGN: a cross-sectional survey was conducted using a questionnaire administered to adult patients with IBD in a tertiary medical facility. RESULTS: Among the participants who answered the questionnaire, 92.6%, 91.5%, and 41.5% of the participants had received their first, second, and third doses of the COVID-19 vaccine, respectively. Of the vaccinated participants, 88.3%, 86.3%, and 89.0% experienced side effects after receiving the first, second, and third doses of the vaccine, respectively. The incidences of fever, chills, and headaches were significantly higher among female participants than among male participants (p < 0.05). However, the frequencies of most side effects were comparable between the BNT162b2 mRNA and mRNA-1273 vaccines. CONCLUSION: The findings of our survey can help encourage patients with IBD to receive the COVID-19 vaccine.
    2022年09月, Digestive diseases and sciences, 英語, 国際誌
    研究論文（学術雑誌）

  • Ryutaro Yoshida, Yoshihiko Yano, Namiko Hoshi, Norihiro Okamoto, Yunlong Sui, Atsushi Yamamoto, Naoki Asaji, Yuuki Shiomi, Eiichiro Yasutomi, Yuri Hatazawa, Hiroki Hayashi, Yoshihide Ueda, Yuzo Kodama
    Resistant starch (RS) has been reported to improve steatosis as well as obesity. Type 4 resistant starch (RS4), a chemically modified starch, is particularly hard to digest and suggesting higher efficacy. However, because the effects of RS4 on steatosis are not yet fully understood, the effects of RS4 on steatosis were examined using a murine high-fat diet model. Seven-week-old male mice were divided into three groups and fed a normal diet, a high-fat diet (HFD), or a high-fat diet with added RS (HFD + RS). Amylofiber SH® produced from acid-treated corn starch was used as the dietary RS. At 22 weeks old, hepatic steatosis and short chain fatty acid (SCFA) content and gut microbiota in cecum stool samples were analyzed. The ratio of body weight to 7 weeks was significantly suppressed in the HFD + RS group compared to the HFD group (132.2 ± 1.4% vs. 167.2 ± 3.9%, p = 0.0076). Macroscopic and microscopic steatosis was also suppressed in the HFD + RS group. Analysis of cecum stool samples revealed elevated SCFA levels in the HFD + RS group compared with the HFD group. Metagenome analysis revealed that Bifidobacterium (17.9 ± 1.9% vs. 3.6 ± 0.7%, p = 0.0019) and Lactobacillus (14.8 ± 3.4% vs. 0.72 ± 0.23%, p = 0.0045), which degrade RS to SCFA, were more prevalent in the HFD + RS group than the HFD group. In conclusion, RS4 suppressed steatosis, and increased Bifidobacterium and Lactobacillus, and SCFAs. RS4 may prevent steatosis by modulating the intestinal environment.
    2022年05月, Journal of food science, 87(5) (5), 2173 - 2184, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Haruka Miyazaki, Daisuke Watanabe, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Namiko Hoshi, Makoto Ooi, Yuzo Kodama
    BACKGROUND: Behçet's disease (BD) is a recurrent multisystem inflammatory disease. Anti-tumor necrosis factor (TNF) α agents have been used to treat patients with intestinal BD with severe disease activity or those who are resistant to conventional treatments; however, the long-term efficacy of anti-TNFα agents in intestinal BD remains unclear. In the present study, we investigated the clinical outcomes and predictors of discontinuation of anti-TNFα agents in patients with intestinal BD. METHODS: We reviewed the medical records of patients with intestinal BD who received first-line anti-TNFα agents between January 2009 and June 2020. The primary outcome was the percentage of patients who continued anti-TNFα therapy for 48 weeks. Secondary outcomes included the percentage of patients who achieved marked improvement, complete remission, and mucosal healing, as well as predictors of discontinuation of anti-TNFα agents. RESULTS: A total of 29 patients were included in the study. Twenty-two (75.9%) patients continued anti-TNFα therapy for 48 weeks. The percentage of patients who achieved marked improvement, complete remission, and mucosal healing at week 48 was 48.3%, 37.9%, and 48.3%, respectively. At week 96, 11 (37.9%) patients achieved marked improvement, complete remission, and mucosal healing. A higher C-reactive protein level (CRP; ≥ 1 mg/dL) at baseline was a predictor of discontinuation of anti-TNFα agents. CONCLUSIONS: The 48-week continuation rate of anti-TNFα agents was 75.9% in bio-naïve patients with intestinal BD. However, a higher baseline CRP level (≥ 1 mg/dL) was associated with discontinuation of anti-TNFα agents.
    2022年03月, BMC gastroenterology, 22(1) (1), 149 - 149, 英語, 国際誌
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Namiko Hoshi, Jun Inoue, Daisuke Sasaki, Kengo Sasaki
    The human gut harbors a complex microbial community that performs a range of metabolic, physiological, and immunological functions. The host and its inhabiting microorganisms are often referred to as a "superorganism." Dysbiosis of gut microflora has been associated with the pathogenesis of intestinal disorders including inflammatory bowel disease, colorectal cancer, and extra-intestinal disorders such as cardiovascular disease. Therefore, gut microbiome interventions are important for the prevention and treatment of diseases. However, ethical, economic, scientific, and time constraints limit the outcome of human intervention or animal studies targeting gut microbiota. We recently developed an in vitro batch fermentation model (the Kobe University Human Intestinal Microbiota Model, KUHIMM) that is capable of hosting a majority of gut microbial species in humans and also detects the metabolites produced by microorganisms in real time. In this mini review, we elucidated the characteristics of the KUHIMM and its applicability in analyzing the effect of diet, drugs, probiotics, and prebiotics on intestinal bacteria. In addition, we introduce as examples its application to disease models, such as ulcerative colitis, in which intestinal bacteria are intricately involved in the process of pathogenesis. We also discuss the potential of the KUHIMM in precision medicine. KEY POINTS: • In vitro gut fermentation model to simulate human colonic microbiota • Screening of potential prebiotics and probiotic candidates in healthy model • Construction of disease models of ulcerative colitis and coronary artery disease.
    2021年04月, Applied microbiology and biotechnology, 105(7) (7), 2625 - 2632, 英語, 国際誌
    [査読有り][招待有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Kengo Sasaki, Tomoyuki Mori, Namiko Hoshi, Daisuke Sasaki, Jun Inoue, Reiko Shinkura, Akihiko Kondo
    Abstract W27 monoclonal immunoglobulin A (IgA) suppresses pathogenic Escherichia coli cell growth; however its effect on the human intestine remains unclear. We thus aimed to determine how W27 IgA affects the human colonic microbiota using the in vitro microbiota model. This model was established using fecal samples collected from 12 healthy volunteers; after anaerobic cultivation, each model was found to retain the genera found in the original human fecal samples. After pre-incubating W27 IgA with the respective fecal sample in aerobic condition, the mixture of W27 IgA (final concentration, 0.5 µg/mL) and each fecal sample was added to the in vitro microbiota model and cultured under anaerobic condition,. Next-generation sequencing of the bacterial 16S rRNA gene revealed that W27 IgA addition significantly decreased the relative abundance of bacteria related to the genus Escherichia in the model. Additionally, at a final concentration of 5 µg/mL, W27 IgA delayed growth in pure culture of Escherichia coli isolated from human fecal samples. Our study thus revealed the suppressive effect of W27 IgA on the genus Escherichia at relatively low-concentrations and the usefulness of an in vitro microbiota model to evaluate the effect of IgA as a gut microbiota regulator.
    Research Square, 2021年03月
    神戸大学リポジトリ（Kernel）へのリンク

  • Haruka Miyazaki, Namiko Hoshi, Michitaka Kohashi, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Makoto Ooi, Nobuyuki Yamamoto, Suguru Uemura, Noriyuki Nishimura, Kazumoto Iijima, Keisuke Jimbo, Tsubasa Okano, Akihiro Hoshino, Kohsuke Imai, Hirokazu Kanegane, Ichiro Kobayashi, Yuzo Kodama
    Autoimmune enteropathy (AIE) is a rare disease, characterized by intractable diarrhea, villous atrophy of the small intestine, and the presence of circulating anti-enterocyte autoantibodies. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and mutations in FOXP3, which is a master gene of regulatory T cells (Tregs), are major causes of AIE. Recent studies have demonstrated that mutations in other Treg-associated genes, such as CD25 and CTLA4, show an IPEX-like phenotype. We present the case of a 13-year-old girl with CTLA4 haploinsufficiency, suffering from recurrent immune thrombocytopenic purpura and intractable diarrhea. We detected an autoantibody to the AIE-related 75 kDa antigen (AIE-75), a hallmark of the IPEX syndrome, in her serum. She responded well to a medium dose of prednisolone and a controlled dose of 6-mercaptopurine (6-MP), even after the cessation of prednisolone administration. Serum levels of the soluble interleukin-2 receptor and immunoglobulin G (IgG) were useful in monitoring disease activity during 6-MP therapy. In conclusion, autoimmune-mediated mechanisms, similar to the IPEX syndrome, may be involved in the development of enteropathy in CTLA4 haploinsufficiency. Treatment with 6-MP and monitoring of disease activity using serum levels of soluble interleukin-2 receptor and IgG is suggested for such cases.
    2021年01月, Intestinal research, 20(1) (1), 144 - 149, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Effect of Daikenchuto On Spontaneous Intestinal Tumors in ApcMin/+ Mice.
    Lingling Kong, Namiko Hoshi, Daisuke Watanabe, Yasutaka Yamada, Eiichiro Yasutomi, Soichiro Adachi, Makoto Ooi, Yunlong Sui, Ryutaro Yoshida, Ryohei Sekimoto, Eri Tokunaga, Haruka Miyazaki, Yuna Ku, Haruka Takenaka, Tadao Kunihiro, Jun Inoue, Zibin Tian, Yuzo Kodama
    Daikenchuto (TU-100) is herbal medicine which predominantly contains ginger, Japanese pepper, and ginseng. We investigated whether TU-100 can affect the composition of gut flora and intestinal tumor development using ApcMin/+ mice, a murine model of intestinal tumor. Bacterial 16S rRNA sequencing and short-chain fatty acid analysis were performed on faecal samples. Tumor number and size were analysed. Any change in gene expression of the tumor tissues was assessed by real-time PCR. Principal coordinate analysis (PCoA) showed that the faecal microbiota cluster of TU-100-fed mice was different from the microbiota of control mice. However, no significant difference was observed in the concentration of short-chain fatty acids, tumor number, and gene expression levels between the two groups. Our data showed that TU-100 can affect the intestinal environment; however, it does not contribute in tumor progression or inhibition in our setting.
    2021年01月, The Kobe journal of medical sciences, 66(4) (4), E139-E148, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Lingling Kong, Namiko Hoshi, Yunlong Sui, Yasutaka Yamada, Ryutaro Yoshida, Makoto Ooi, Zibin Tian, Ikuo Kimura, Yuzo Kodama
    S. Karger AG, 2021年, Medical Principles and Practice, 英語
    研究論文（学術雑誌）

  • Jing Zhao, Shin Nishiumi, Ryoma Tagawa, Yoshihiko Yano, Jun Inoue, Namiko Hoshi, Masaru Yoshida, Yuzo Kodama
    Adrenic acid (ADA), which is an endogenously synthesized polyunsaturated free fatty acid, was significantly increased in nonalcoholic fatty liver disease (NAFLD) patients and NAFLD-model mice compared with the corresponding controls in our previous study. To elucidate the involvement of ADA in NAFLD and nonalcoholic steatohepatitis (NASH), we examined ADA-induced lipotoxicity in human hepatocarcinoma HepG2 cells. The ROS production in HepG2 cells was increased by exposure to ADA. It was also shown that the treatment with ADA decreased cell viability in a dose-dependent manner. The N-Acetyl-L-Cysteine pretreatment counteracted this ADA-induced ROS production and cell death. Furthermore, ADA modulated the expressions of SOD2, HO-1 and Gpx1 as antioxidant enzymes. These findings suggest that ADA could induce oxidative stress accompanied by cell death, providing new insights into lipotoxicity that is involved in the pathogenesis of NAFLD and NASH.
    2020年11月, Biochemical and biophysical research communications, 532(4) (4), 620 - 625, 英語, 国際誌
    研究論文（学術雑誌）

  • Kengo Sasaki, Daisuke Sasaki, Jun Inoue, Namiko Hoshi, Takayuki Maeda, Ryouichi Yamada, Akihiko Kondo
    The aim of this study was to clarify the effect of the spore-forming and lactic acid-producing probiotic strain, Bacillus coagulans SANK 70258, on human colonic microbiota of healthy subjects and ulcerative colitis patients. A model culture system was employed to construct the in vitro human colonic microbiota, to retain the bacterial species richness and simulate the patient's disordered composition, from the fecal inoculum. Bacterial 16S rRNA gene sequencing confirmed that administration of B. coagulans SANK 70258 (at an initial concentration of 4 × 107-total cells/mL) suppressed bacteria related to the family Enterobacteriaceae in the microbiota models for both healthy subjects (P = 0.016) and ulcerative colitis patients (P = 0.023). In addition, administration of B. coagulans SANK 70258 increased bacteria related to the family Lachnospiraceae (P = 0.031), thereby enhancing butyrate production (P = 0.031) in the microbiota models of healthy subjects. However, these changes were not observed in the microbiota models of ulcerative colitis patients, likely owing to the low abundance of Lachnospiraceae species. This study demonstrates the potential of B. coagulans SANK 70258 to exhibit antimicrobial activity against harmful organisms in patients with ulcerative colitis, while improving the intestinal microenvironment by increasing butyrogenesis in healthy persons. KEY POINTS: • B. coagulans SANK 70258 treatment reduced colonic Enterobacteriaceae species. • B. coagulans SANK 70258 treatment enhanced butyrogenesis in healthy individuals. • B. coagulans SANK 70258 treatment increased Lachnospiraceae in healthy persons. • B. coagulans SANK 70258 improves the colonic microenvironment in ulcerative colitis.
    2020年03月, Applied microbiology and biotechnology, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Daisuke Watanabe, Namiko Hoshi, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Ohara, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki, Yuzo Kodama
    2019年12月, Journal of Gastroenterology and Hepatology (Australia), 34(12) (12), 2158 - 2163
    [査読有り]
    研究論文（学術雑誌）

  • Ryohei Shinohara, Kengo Sasaki, Jun Inoue, Namiko Hoshi, Itsuko Fukuda, Daisuke Sasaki, Akihiko Kondo, Ro Osawa
    Microbial production of butyrate is impaired in patients with ulcerative colitis (UC); however, this inhibition is not well understood in Japanese UC patients. Therefore, we quantitatively analyzed genes encoding butyryl-CoA:acetate CoA-transferase (but) and butyrate kinase (buk) in the gut microbiota of Japanese patients with UC and healthy volunteers (HVs). But showed higher levels than buk. Moreover, patients with UC showed significantly decreased levels of but associated with Roseburia sp./Eubacterium rectale compared with HVs. But, which is associated with Faecalibacterium sp., was maintained in patients with UC, with an unchanged relative abundance of Faecalibacterium sp. microorganisms in patients with UC compared with HVs.
    2019年10月, Bioscience of Microbiota, Food and Health, 38(4) (4), 159 - 163, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Chonlada Krutsri, Takashi Toyonaga, Tsukasa Ishida, Namiko Hoshi, Shinichi Baba, Nelson Tomio Miyajima, Yuzo Kodama
    Background and study aims  Patients who have undergone colorectal surgery for resection of cancer and benign lesions are at risk for recurrent, residual, or metachronous lesions at the anastomosis site. Surgical resection of such lesions is difficult because of adhesions, and a stoma may be required as there are risks for leakage after resection. The feasibility and safety of endoscopic submucosal dissection (ESD) for these lesions remain unknown. Therefore, this case series aimed to examine the feasibility and safety of ESD by evaluating the clinical outcomes. Patients and methods  We retrospectively investigated five patients who underwent ESD by a single expert for superficial neoplastic lesions at the anastomosis site after previous colorectal surgery. Results  R0 resections were achieved for all lesions. Mean procedure time was 160.6 minutes. Mean dimensions of the resected specimen and tumor were 52.4 mm and 31.8mm, respectively. None of the patients had complications or recurrence after surveillance colonoscopy 1-year post-resection. Conclusions  In an expert's hands, ESD at the anastomosis site might be feasible minimally invasive treatment for superficial neoplastic lesions.
    2019年08月, Endoscopy international open, 7(8) (8), E949-E954, 英語, 国際誌
    [査読有り]
    神戸大学リポジトリ（Kernel）へのリンク

  • Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama
    2019年03月, Biochemical and Biophysical Research Communications, 511(1) (1), 99 - 104, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Construction of a Model Culture System of Human Colonic Microbiota to Detect Decreased Lachnospiraceae Abundance and Butyrogenesis in the Feces of Ulcerative Colitis Patients
    Sasaki K, Inoue J, Sasaki D, Hoshi N, Shirai T, Fukuda I, Azuma T, Kondo A, Osawa R
    2019年02月, Biotechnol J, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • 佐々木 建吾, 井上 潤, 佐々木 大介, 星 奈美子, 白井 智量, 福田 伊津子, 東 健, 近藤 昭彦, 大澤 朗
    Compositional alteration of the gut microbiota is associated with ulcerative colitis (UC). Here, a model culture system is established for the in vitro human colonic microbiota of UC, which will be helpful for determining medical interventions. 16S ribosomal RNA sequencing confirms that UC models are successfully developed from fecal inoculum and retain the bacterial species biodiversity of UC feces. The UC models closely reproduce the microbial components and successfully preserve distinct clusters from the healthy subjects (HS), as observed in the feces. The relative abundance of bacteria belonging to the family Lachnospiraceae significantly decreases in the UC models compared to that in HS, as observed in the feces. The system detects significantly lower butyrogenesis in the UC models than that in HS, correlating with the decreased abundance of Lachnospiraceae. Interestingly, the relative abundance of Lachnospiraceae does not correlate with disease activity (defined as partial Mayo score), suggesting that Lachnospiraceae persists in UC patients at a decreased level, irrespective of the alteration in disease activity. Moreover, the system shows that administration of Clostridium butyricum MIYAIRI restores butyrogenesis in the UC model. Hence, the model detects deregulation in the intestinal environment in UC patients and may be useful for simulating the effect of probiotics.
    2019年, Biotechnology Journal, 14(5) (5), e1800555, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Naofumi Yoshida, Takuo Emoto, Tomoya Yamashita, Hikaru Watanabe, Tomohiro Hayashi, Tokiko Tabata, Namiko Hoshi, Naoya Hatano, Genki Ozawa, Naoto Sasaki, Taiji Mizoguchi, Hilman Zulkifli Amin, Yushi Hirota, Wataru Ogawa, Takuji Yamada, Ken-Ichi Hirata
    BACKGROUND: It is increasingly recognized that gut microbiota play a pivotal role in the development of atherosclerotic cardiovascular disease. Previously, we have reported that the abundance of genus Bacteroides is lower in patients with coronary artery disease (CAD) than in patients without CAD with coronary risk factors or in healthy volunteers. However, it remains unclear which and how specific gut bacteria contribute to the progression of atherosclerosis. METHODS: We recruited patients with CAD patients and controls without CAD with coronary risk factors. We then compared gut microbial composition using 16S ribosomal RNA gene sequencing in fecal samples to detect species with differential abundance between 2 groups. Subsequently, we used atherosclerosis-prone mice to study the mechanisms underlying the relationship between such species and atherosclerosis. RESULTS: Human fecal 16S ribosomal RNA gene sequencing revealed a significantly lower abundance of Bacteroides vulgatus and Bacteroides dorei in patients with CAD. This significant differential abundance was confirmed by quantitative polymerase chain reaction. Gavage with live B. vulgatus and B. dorei attenuated atherosclerotic lesion formation in atherosclerosis-prone mice, markedly ameliorating endotoxemia followed by decreasing gut microbial lipopolysaccharide production, effectively suppressing proinflammatory immune responses. Furthermore, fecal lipopolysaccharide levels in patients with CAD were significantly higher and negatively correlated with the abundance of B. vulgatus and B. dorei. CONCLUSIONS: Our translational research findings identify a previously unknown link between specific gut bacteria and atherosclerosis. Treatment with live B. vulgatus and B. dorei may help prevent CAD. CLINICAL TRIAL REGISTRATION: URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018051 . Unique identifier: UMIN000015703.
    2018年11月, Circulation, 138(22) (22), 2486 - 2498, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Daisuke Watanabe, Namiko Hoshi, Hirohumi Abe, Ryusuke Ariyoshi, Yoshiko Ohara, Tsukasa Ishida, Toshitatsu Takao, Yoshinori Morita, Eiji Umegaki
    A 73-year-old female with a 6-month history of progressive dysphagia and chest pain was referred to our hospital. She underwent esophagogastroduodenoscopy, which revealed abnormally strong contractions in the distal esophagus. Esophageal biopsy specimens showed massive eosinophil infiltration into the epithelium, and high-resolution manometry (HRM) also demonstrated abnormally strong contractions in the distal esophagus. Based on these results, she was diagnosed with Jackhammer esophagus (JHE) due to eosinophilic esophagitis (EoE). Treatment was started with 5 mg/day of prednisolone (PSL), and the number of peripheral blood eosinophils quickly decreased without any improvement in the patient's dysphagia. Esophageal biopsy specimens obtained after the PSL treatment showed the disappearance of eosinophils from the epithelium. However, abnormally strong contractions were still detected on HRM. Per-oral endoscopic myotomy (POEM) was performed to treat the JHE. Interestingly, the intraoperative esophageal muscle biopsy sample demonstrated massive eosinophil infiltration into the muscle layer. After the POEM, the patient's symptoms improved, and abnormal contractions were no longer detected on HRM. The current case suggests that when EoE combined with an esophageal motility disorder are refractory to steroid therapy, clinicians should be aware that motility disorders can develop due to eosinophil infiltration deep into the esophageal muscularis propria.
    2018年10月, Clinical journal of gastroenterology, 11(5) (5), 377 - 381, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Eiichiro Yasutomi, Namiko Hoshi, Soichiro Adachi, Takafumi Otsuka, Lingling Kong, Yuna Ku, Haruka Yamairi, Jun Inoue, Tsukasa Ishida, Daisuke Watanabe, Makoto Ooi, Masaru Yoshida, Tomoya Tsukimi, Shinji Fukuda, Takeshi Azuma
    BACKGROUND AND AIMS: Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in this study, we explored whether Lansoprazole (Laz), one of the PPIs, increases the susceptibility to enteropathogens, and further investigated the mechanism of it. METHODS: Mice were administered Laz intraperitoneally once daily and orally infected with Citrobacter rodentium (C. rodentium). The establishment of intestinal infection was assessed by histology and inflammatory cytokine expression levels measured by quantitative PCR. To test whether Laz changes the intestinal environment to influence the susceptibility, intestinal pH, microbiota, metabolites and immune cell distributions were evaluated via pH measurement, 16S rRNA gene sequencing, metabolome, and flow cytometry analyses after Laz administration. RESULTS: Colitis was induced with less C. rodentium in Laz-treated mice as compared with the controls. We found that increased numbers of C. rodentium could reach the cecum following Laz administration. Laz increased pH in the stomach but not in the intestines. It induced dysbiosis and changed the metabolite content of the small intestine. However, these changes did not lead to alterations of immune cell distribution. CONCLUSIONS: Laz raised susceptibility to C. rodentium as increased numbers of the pathogen reach the site of infection. Our results suggest that it was due to increased stomach pH which allowed more peroral enteropathogens to pass the stomach, but not because of changes of intestinal environment.
    2018年04月, Digestive diseases and sciences, 63(4) (4), 881 - 889, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Haruhiro Inoue, Robert Bechara, Namiko Hoshi, Hirohumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
    BACKGROUND AND AIM: One of the challenges during peroral endoscopic myotomy (POEM) is ensuring the appropriate length of myotomy on the gastric side. To determine the appropriate distal end of the gastric myotomy, we focused on the two penetrating vessels (TPVs) found in the gastric cardia during POEM. In the present study, we evaluated whether the TPVs could serve as an accurate indicator of the appropriate distal end of the gastric myotomy. METHODS: All patients who underwent POEM between March and August 2016 were included for this study. When making the submucosal tunnel in the 5 o'clock direction into the stomach, two vessels penetrating through the circular muscle along the edge of oblique muscle in the cardia can be exposed. We designated these two vessels as TPVs. The myotomy was extended until the second TPVs was exposed. The anal end of the submucosal tunnel was confirmed by the double-scope POEM technique, and the length from the gastroesophageal junction to the anal side end of the myotomy was measured by the scale on the endoscope. RESULTS: Among 37 patients who underwent myotomy in the 5 o'clock position, TPVs were found in 34 patients (91.2%). Sufficient submucosal tunneling on the gastric side was confirmed by the double-scope POEM technique in these 34 patients. Median length of the gastric myotomy was 3.0 cm (range 2-4 cm). CONCLUSION: TPVs appears to be a simple and reliable indicator to determine the appropriate distal end of myotomy.
    2018年03月, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 30(2) (2), 206 - 211, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T
    Due to the heterogeneous pathology of traumatic brain injury (TBI), the exact mechanism of how initial brain damage leads to chronic inflammation and its effects on the whole brain remain unclear. Here, we report on long-term neuroinflammation, remote from the initial injury site, even after subsiding of the original inflammatory response, in a focal TBI mouse model. The use of translocator protein-positron emission tomography in conjunction with specialised magnetic resonance imaging modalities enabled us to visualize "previously undetected areas" of spreading inflammation after focal cortical injury. These clinically available modalities further revealed the pathophysiology of thalamic neuronal degeneration occurring as resident microglia sense damage to corticothalamic neuronal tracts and become activated. The resulting microglial activation plays a major role in prolonged inflammatory processes, which are deleterious to the thalamic network. In light of the association of this mechanism with neuronal tracts, we propose it can be termed "brain injury related inflammatory projection". Our findings on multiple spatial and temporal scales provide insight into the chronic inflammation present in neurodegenerative diseases after TBI.
    2018年, Neuroimage Clin, 20, 946 - 954, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yosuke Yagi, Atsuhiro Masuda, Yoh Zen, Hideyuki Shiomi, Hirochika Toyama, Keitaro Sofue, Mamoru Takenaka, Takashi Kobayashi, Takashi Nakagawa, Kodai Yamanaka, Takuya Ikegawa, Namiko Hoshi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma
    Elsevier {BV}, 2018年01月, Pancreatology, 18(1) (1), 54 - 60, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Fumiaki Kawara, Takashi Toyonaga, Robert Bechara, Namiko Hoshi, Hirofumi Abe, Yoshiko Ohara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
    Background and study aims : In order to perform peroral endoscopic myotomy (POEM) safely, retained liquid and food debris must be removed before the procedure is started. We developed a novel technique using a super-slim gastroscope, and a gastric tube to remove retained food debris in achalasia patients. In this study, the safety and efficacy of this novel technique were investigated. Patients and methods : Eleven patients with achalasia were enrolled in this study and underwent this novel method for esophageal clearance. Results:  All patients had complete clearance of the retained food debris using this method. The median procedure time (range) was 13 (6 - 30) minutes. There were no serious adverse events (AEs) and one minor AE of mucosal erythema due to mucosal suctioning. Conclusion:  This novel method for esophageal clearance is safe and effective in achalasia patients with large amounts of retained food debris.
    2018年01月, Endoscopy international open, 6(1) (1), E86-E89 - E89, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Short-term and long-term outcomes of infliximab and tacrolimus treatment for moderate to severe ulcerative colitis: Retrospective observational study
    Takafumi Otsuka, Makoto Ooi, Kazutoshi Tobimatsu, Chika Wakahara, Daisuke Watanabe, Soichiro Adachi, Eiichiro Yasutomi, Haruka Yamairi, Yuna Ku, Masaru Yoshida, Namiko Hoshi, Yuzo Kodama
    2018年, Kobe Journal of Medical Sciences, 64(4) (4), E140 - E148, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Tsukasa Ishida, Takashi Toyonaga, Yoshiko Ohara, Tadao Nakashige, Yasuaki Kitamura, Ryusuke Ariyoshi, Hiroshi Takihara, Shinichi Baba, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Yoshinori Morita, Eiji Umegaki, Namiko Hoshi, Takeshi Azuma
    2017年08月, WORLD JOURNAL OF GASTROENTEROLOGY, 23(29) (29), 5422 - 5430, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Shinwa Tanaka, Takashi Toyonaga, Fumiaki Kawara, Ian S Grimm, Namiko Hoshi, Hirofumi Abe, Yoshiko Ohara, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    BACKGROUND AND STUDY AIMS : Peroral endoscopic myotomy (POEM) is an evolving new treatment strategy for achalasia. Although several kinds of electrosurgical knives have been used in performing POEM, the best device has yet to be determined. The FlushKnife BT is a waterjet-emitting short needle-knife with a small ball tip (BT) that offers the potential to perform all aspects of POEM with a single device. In this study, we evaluated the safety and efficiency of the FlushKnife BT for POEM. PATIENTS AND METHODS:  A total of 54 consecutive patients with achalasia and other spastic esophageal motility disorders, such as jackhammer esophagus or distal esophageal spasm, who underwent POEM between January 2016 and August 2016, were included in this retrospective study. RESULTS:  The median operation time was 73.0 minutes (range 39 - 184 minutes). All procedures were completed using only the FlushKnife BT without changing to any other electrosurgical instrument. The median number of additional submucosal injections with an injection needle was 0 (range 0 - 1). Endoscopic vessel sealing was performed a mean of 3 times (range 0 - 7). The median number of bleeding episodes requiring treatment with hemostatic forceps was 0 (range 0 - 5). There were no significant adverse events. Seven of 52 patients (13.5 %) reported symptoms of gastroesophageal reflux disease such as heartburn or acid reflux at 3 month follow-up. CONCLUSIONS:  The FlushKnife BT enabled POEM to be performed with very few device exchanges, either for re-injection or to control intraoperative bleeding. In this uncontrolled case series, the ability of the FlushKnife BT to perform nearly all aspects of the POEM procedure seems to make it particularly well suited to this procedure.
    2017年07月, Endoscopy international open, 5(7) (7), E663-E669 - E669, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Fumiaki Kawara, Shinwa Tanaka, Takashi Yamasaki, Yoshinori Morita, Yoshiko Ohara, Yoshihiro Okabe, Namiko Hoshi, Takashi Toyonaga, Eiji Umegaki, Hiroshi Yokozaki, Takanori Hirose, Takeshi Azuma
    2017年06月, WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 9(6) (6), 263 - 267, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • W. K. Eddie Ip, Namiko Hoshi, Dror S. Shouval, Scott Snapper, Ruslan Medzhitov
    2017年05月, SCIENCE, 356(6337) (6337), 513 - 519, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Kevin L Grimes, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma
    BACKGROUND AND AIM: Currently, endoscopic submucosal dissection (ESD) is a widely accepted standard treatment for early gastric cancer, but one challenging aspect of ESD is hemostasis. We developed a new hemostatic forceps (FD-Y0007) with the aim of achieving more effective hemostasis and investigated the hemostatic ability of the FD-Y0007 during gastric ESD in humans. METHODS: This study was a prospective randomized controlled trial, which was conducted at a cancer referral center. Sixty-six patients who were scheduled to undergo ESD were enrolled and randomly assigned to either the Coagrasper or the FD-Y0007, which was used for hemostasis throughout the case. The primary end point was the time required to obtain hemostasis, which was measured for the first episode of bleeding during each case. RESULTS: Hemostasis time for the first bleeding episode during ESD was 73.0 s for the Coagrasper and 21.5 s for the FD-Y0007 (P < 0.001). When all episodes of bleeding were included, hemostasis time was 56.8 s in the Coagrasper group and 25.5 s in FD-Y0007group (P < 0.0001). The frequency of adverse events (perforation: 3.4% vs 7.1%; delayed bleeding: 0% vs 0%) was not significantly different between the two groups. CONCLUSIONS: Compared with the Coagrasper, the FD-Y0007 efficiently reduces the hemostatic time during gastric ESD with no increase in adverse events.
    2017年04月, Journal of gastroenterology and hepatology, 32(4) (4), 846 - 851, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Tsukasa Ishida, Namiko Hoshi, Kevin L. Grimes, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma
    2017年04月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32(4) (4), 846 - 851, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshiko Ohara, Takashi Toyonaga, Namiko Hoshi, Shinwa Tanaka, Shinichi Baba, Hiroshi Takihara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    2017年03月, WORLD JOURNAL OF GASTROENTEROLOGY, 23(9) (9), 1657 - 1665, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Usefulness of a novel slim type FlushKnife-BT over conventional FlushKnife-BT in esophageal endoscopic submucosal dissection
    Yoshiko Ohara, Takashi Toyonaga, Namiko Hoshi, Shinwa Tanaka, Shinichi Baba, Hiroshi Takihara, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    2017年03月, WORLD JOURNAL OF GASTROENTEROLOGY, 23(9) (9), 1657 - 1665, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Soichiro Adachi, Namiko Hoshi, Jun Inoue, Eiichiro Yasutomi, Takafumi Otsuka, Ramesh Dhakhwa, Zi Wang, Yuna Koo, Toshihiro Takamatsu, Yuriko Matsumura, Haruka Yamairi, Daisuke Watanabe, Makoto Ooi, Toshihito Tanahashi, Shin Nishiumi, Masaru Yoshida, Takeshi Azuma
    2017年, INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 173(1) (1), 23 - 33, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yosuke Yagi, Atsuhiro Masuda, Yoh Zen, Mamoru Takenaka, Hirochika Toyama, Keitaro Sofue, Hideyuki Shiomi, Takashi Kobayashi, Takashi Nakagawa, Koudai Yamanaka, Namiko Hoshi, Masaru Yoshida, Yoshifumi Arisaka, Yoshihiro Okabe, Hiromu Kutsumi, Takumi Fukumoto, Yonson Ku, Takeshi Azuma
    Elsevier {BV}, 2016年09月, Pancreatology, 16(5) (5), 893 - 899, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Harold Jacob, Takashi Toyonaga, Yoshiko Ohara, Eiji Tsubouchi, Hiroshi Takihara, Shinichi Baba, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    2016年09月, ENDOSCOPY, 48(9) (9), 829 - 836, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tetsuya Yoshizaki, Takashi Toyonaga, Shinwa Tanaka, Yoshiko Ohara, Fumiaki Kawara, Shinichi Baba, Eiji Tsubouchi, Hiroshi Takihara, Daisuke Watanabe, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    BACKGROUND AND STUDY AIM: Endoscopic submucosal dissection (ESD) has been applied to treat early colorectal cancers. The aim of this study was to clarify the clinical course of ESD for lesions involving the ileocecal valve (ICV) by evaluating the successful resection rates, and the risk and frequency of adverse events. PATIENTS AND METHODS: The outcome of ESD on 38 ICV lesions was compared with the outcome of 132 cecal lesions that did not involve the ICV or appendiceal orifice during the same study period. The factors related to longer procedure time, postoperative stricture development, and tumor recurrence were investigated for ESD of ICV lesions. RESULTS: There was no significant difference between the ICV and non-ICV groups in the en block resection rates. The median procedure time was significantly longer in the ICV group than in the non-ICV group, with a point estimate of the difference of 37 minutes (95 % confidence interval [CI] 20.00 to 56.00; P  < 0.01). None of the patients developed symptomatic post-ESD stricture or tumor recurrence. ESD procedure duration was ≥ 120 minutes in 16 lesions and < 120 minutes in 22 lesions of the ICV group. A specimen diameter of ≥ 40 mm and tumor extension into terminal ileum were factors related to a longer procedure time (odds ratio [OR] 8.40, 95 %CI 1.53 to 46.10, P = 0.01; OR 10.60, 95 %CI 2.17 to 51.40, P  < 0.01, respectively). CONCLUSIONS: ICV lesions can be resected by ESD without major adverse events or causing symptomatic stricture development. However, ESD for ICV lesions should be performed only by expert endoscopists, as the procedure requires accomplished endoscopic skill and experience.
    2016年07月, Endoscopy, 48(7) (7), 639 - 45, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Optimization of steroid injection intervals for prevention of stricture after esophageal endoscopic submucosal dissection: A randomized controlled trial
    Chika Wakahara, Yoshinori Morita, Shinwa Tanaka, Namiko Hoshi, Fumiaki Kawara, Megumi Kibi, Tsukasa Ishida, Mariko Man-, Tsuyoshi Fujita, Takashi Toyonaga
    2016年07月, ACTA GASTRO-ENTEROLOGICA BELGICA, 79(3) (3), 315 - 320, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Namiko Hoshi, Tsukasa Ishida, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Eiji Umegaki, Takeshi Azuma
    2016年07月, WORLD JOURNAL OF GASTROENTEROLOGY, 22(27) (27), 6268 - 6275, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Optimization of steroid injection intervals for prevention of stricture after esophageal endoscopic submucosal dissection: A randomized controlled trial
    Chika Wakahara, Yoshinori Morita, Shinwa Tanaka, Namiko Hoshi, Fumiaki Kawara, Megumi Kibi, Tsukasa Ishida, Mariko Man-I, Tsuyoshi Fujita, Takashi Toyonaga
    Universa Press, 2016年, Acta Gastro-Enterologica Belgica, 79(3) (3), 315 - 320, 英語
    研究論文（学術雑誌）

  • Evaluation of the xenobiotic reaction against hyaluronate-based bioresorbable membrane in the abdominal cavity
    NagataM, Hoshi Namiko, YoshinakaH, Shiomi Hideyuki, TakenakaM, MasudaA, MaruyamaY, UchidaR, AzumaT, KutsumiH
    2016年, Prog Biomater, 5(2) (2), 111 - 116, 英語
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yoshiko Ohara, Takashi Toyonaga, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Tetsuya Yoshizaki, Fumiaki Kawara, Ka Luen Lui, Kanokkan Tepmalai, Alisara Damrongmanee, Mitsuru Nagata, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    2016年01月, ENDOSCOPY, 48(1) (1), 62 - 70, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshiko Ohara, Takashi Toyonaga, Daisuke Watanabe, Namiko Hoshi, Soichiro Adachi, Tetsuya Yoshizaki, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Tatsuya Okuno, Nobunao Ikehara, Yoshinori Morita, Eiji Umegaki, Hiroshi Yokozaki, Takeshi Azuma
    A 66-year-old woman presented to us with malaise, anorexia and rectal mucous discharge, and her laboratory data showed severe hyponatremia, hypokalemia, hypochloremia and renal failure. Computed tomography revealed massive occupation of the rectum by a large tumor. Colonoscopy revealed a mucus-rich villous tumor in the rectum. As there were no other factors that could cause an electrolyte disorder, she was diagnosed with McKittrick-Wheelock syndrome (MWS). The current standard treatment for MWS is partial surgical colectomy. However, surgeries are invasive and postoperative complications sometimes become an issue. After confirming no signs of submucosal invasion of the tumor by magnifying chromoendoscopic examination, endoscopic submucosal dissection (ESD) was indicated. The tumor was completely removed en bloc without adverse events. The histology showed a mucosal adenocarcinoma containing a villous component, 24.5 x 17.0 cm in size. This removal dramatically improved the patient's symptoms and the electrolyte abnormalities without medication. Although several sessions of endoscopic balloon dilation were required to treat postoperative stricture, she has been symptom-free and had no recurrence for 4 years after treatment. We experienced a case of MWS treated by ESD instead of surgery. ESD should be feasible and beneficial for the treatment of MWS.
    2015年10月, Clinical journal of gastroenterology, 8(5) (5), 280 - 4, 英語, 国内誌
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Yoshinori Morita, Namiko Hoshi, Tsukasa Ishida, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Takeshi Azuma
    PURPOSE: Recently, endoscopic submucosal dissection (ESD) has been applied for superficial colorectal neoplasms and the number of publications about it has been increasing, but little is known about the outcomes of colorectal ESD for the lesions > 50 mm. In this study, we evaluated the feasibility and safety of colorectal ESD for the lesions > 50 mm compared with the lesions < 50 mm. METHODS: A total of 674 superficial colorectal neoplasms in 629 patients treated by ESD at Kobe University Hospital from July 2008 to July 2013 were included in the analysis. RESULTS: The median operation time (range) in the large lesion group (≥ 5 cm) was 109 (37 to 596) minutes, and it was 55 (6 to 248) minutes in the small lesion group (< 5 cm). Median procedure speed (range) in the large lesion group was 0.28 (0.06 to 0.83) cm2/min, and it was 0.19 (0.04 to 0.83) cm2/min in the small lesion group. The en bloc resection rate and the curative resection rate in the small lesion group was 98.7% and 96.0%, and those were 95.7% and 91.4% in the large lesion group, respectively. In terms of adverse events, perforation, muscle damage, and postoperative bleeding occurred at similar frequency in both groups. CONCLUSIONS: ESD on colorectal lesions > 50 mm takes longer operation time; however, it is resected time effectively without increasing the risk of adverse events compared with smaller lesions by ESD.
    2015年06月, Surgical laparoscopy, endoscopy & percutaneous techniques, 25(3) (3), 223 - 8, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）

  • Takashi Toyonaga, Shinwa Tanaka, Mariko Man-I, James East, Wataru Ono, Eisei Nishino, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Takeshi Azuma
    BACKGROUND AND STUDY AIMS: During colorectal endoscopic submucosal dissection (ESD), the feature of a muscle layer being pulled toward a neoplastic tumor is sometimes detected. We call this feature the muscle-retracting sign (MR sign). The aim of this study was to evaluate whether the MR sign is associated with particular types of neoplastic lesions and whether it has any clinical significance for ESD sessions. PATIENTS AND METHODS: A total of 329 patients underwent ESD for 357 colorectal neoplasms. The frequency of positivity for the MR sign was evaluated in different morphologic and histopathologic types of neoplasm. The success rate of complete resection and the incidence of complications were also evaluated according to whether lesions were positive or negative for the MR sign. RESULTS: The rates of positivity for the MR sign in the various lesion types were as follows: laterally spreading tumor - granular nodular mixed type (LST-G-M), 9.6 %; laterally spreading tumor - granular homogeneous type (LST-G-H) and laterally spreading tumor - nongranular type (LST-NG), 0 %; sessile type, 41.2 %. The resection rate was 100 % (329 /329) in lesions negative for the MR sign; however, it was 64.3 % (18 /28) in lesions positive for the MR sign, which was significantly lower (P < 0.001). CONCLUSIONS: The MR sign was present only in some protruding lesions, and more importantly, it was associated with a high risk of incomplete tumor removal by ESD. Our data indicate that lesions positive for the MR sign lesions should be dissected with great caution; alternatively, based on the features of the individual case, a switch to surgery should be considered for the benefit of the patient.
    2015年06月, Endoscopy international open, 3(3) (3), E246-51 - 51, 英語, 国際誌
    [査読有り]
    研究論文（学術雑誌）
    神戸大学リポジトリ（Kernel）へのリンク

  • Yang L, Yamamoto K, Nishiumi S, Nakamura M, Matsui H, Takahashi S, Dohi T, Okada T, Kakimoto K, Hoshi N, Yoshida M, Azuma T
    2015年03月, Mucosal Immunol, 8(2) (2), 279 - 295, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Shinwa Tanaka, Takashi Toyonaga, Yoshiko Ohara, Tetsuya Yoshizaki, Fumiaki Kawara, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Takeshi Azuma
    2015年03月, WORLD JOURNAL OF GASTROENTEROLOGY, 21(10) (10), 3121 - 3126, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Tsukasa Ishida, Yoshinori Morita, Namiko Hoshi, Tetsuya Yoshizaki, Yoshiko Ohara, Fumiaki Kawara, Sinwa Tanaka, Yuki Yamamoto, Hiroo Matsuo, Kentaro Iwata, Takashi Toyonaga, Takeshi Azuma
    2015年03月, DIGESTIVE ENDOSCOPY, 27(3) (3), 388 - 391, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Atsuki Ikeda, Namiko Hoshi, Tetsuya Yoshizaki, Yoshimi Fujishima, Tsukasa Ishida, Yoshinori Morita, Yasuo Ejima, Takashi Toyonaga, Yoshihiro Kakechi, Hiroshi Yokosaki, Takeshi Azuma
    2015年, INTERNAL MEDICINE, 54(22) (22), 2803 - 2813, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Sakai, A., Shiomi, H., Okabe, Y., Yagi, Y., Kobayashi, T., Shiomi, Y., Takenaka, M., Hoshi, N., Arisaka, Y., Kutsumi, H., Azuma, T.
    2015年, Clinical Journal of Gastroenterology, 8(2) (2), 103 - 7, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Michitaka Kohashi, Shin Nishiumi, Makoto Ooi, Tomoo Yoshie, Atsuki Matsubara, Makoto Suzuki, Namiko Hoshi, Koji Kamikozuru, Yoko Yokoyama, Ken Fukunaga, Shiro Nakamura, Takeshi Azuma, Masaru Yoshida
    2014年09月, JOURNAL OF CROHNS & COLITIS, 8(9) (9), 1010 - 1021, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Yoshihiko Terashima, Shin Nishiumi, Akihiro Minami, Yuki Kawano, Namiko Hoshi, Takeshi Azuma, Masaru Yoshida
    2014年08月, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 555, 55 - 65, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Simone A. Nish, Dominik Schenten, F. Thomas Wunderlich, Scott Pope, Yan Gao, Namiko Hoshi, Shuang Yu, Xiting Yan, Heung Kyu Lee, Lesley Pasman, Igor Brodsky, Brian Yordy, Hongyu Zhao, Jens C. Bruening, Ruslan Medzhitov
    2014年05月, ELIFE, 3, e01949, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Fumiaki Kawara, Jun Inoue, Mamoru Takenaka, Namiko Hoshi, Atsuhiro Masuda, Shin Nishiumi, Hiromu Kutsumi, Takeshi Azuma, Takeshi Ohdaira
    2014年, DIGESTION, 90(1) (1), 10 - 17, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Daisuke Watanabe, Makoto Ooi, Namiko Hoshi, Michitaka Kohashi, Tomoo Yoshie, Nobunao Ikehara, Masaru Yoshida, Emmy Yanagita, Takashi Yamasaki, Tomoo Itoh, Takeshi Azuma
    2014年, ENDOSCOPY, 46(Suppl 1 UCTN) (Suppl 1 UCTN), E476 - E477, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Namiko Hoshi, Dominik Schenten, Simone A. Nish, Zenta Walther, Nicola Gagliani, Richard A. Flavell, Boris Reizis, Zeli Shen, James G. Fox, Akiko Iwasaki, Ruslan Medzhitov
    2012年10月, NATURE COMMUNICATIONS, 3, 1120, 英語
    [査読有り]
    研究論文（学術雑誌）

  • Park SG, Mathur R, Long M, Hosh N, Hao L, Hayden MS, Ghosh S
    2010年11月, Immunity, 33(5) (5), 791 - 803, 英語
    [査読有り]
    研究論文（学術雑誌）

■ MISC
  • IBDの診療の進め方
    岡本典大, 大井充, 星奈美子
    2024年11月, 臨床雑誌「内科」, 134(5) (5), 992 - 997

  • 小腸病変に対する有効性(1)接着分子を標的とした治療の有効性（小腸と大腸の接着因子の違いを含めて）
    宮﨑はる香, 渡邉大輔, 大井充, 星奈美子
    2024年03月, IBD Research, 18(1) (1), 6 - 10
    [招待有り]

  • 妊娠・出産を希望されるIBD患者の診療を身につける
    具潤亜, 大井充, 星奈美子
    2023年03月, IBD Research, 17(1) (1), 34 - 40
    [招待有り]

  • 潰瘍性大腸炎難治例の第一選択（2）トファシチニブを推奨する立場から
    大井充, 星奈美子
    2021年01月, 臨床消化器内科, 32(2) (2), 136 - 142
    記事・総説・解説・論説等（商業誌、新聞、ウェブメディア）

  • 高性能培養装置による潰瘍性大腸炎腸内細菌叢の是正戦略構築
    佐々木 建吾, 星 奈美子
    2019年10月, メディカル・サイエンス・ダイジェスト, 45(12) (12), 42 - 45, 日本語
    記事・総説・解説・論説等（学術雑誌）

  • 日本人潰瘍性大腸炎患者の腸内細菌叢における2種の酪酸産生遺伝子の定量
    篠原 涼平, 佐々木 建吾, 井上 潤, 星 奈美子, 福田 伊津子, 佐々木 大介, 近藤 昭彦, 大澤 朗
    (公財)日本ビフィズス菌センター, 2019年04月, 腸内細菌学雑誌, 33(2) (2), 105 - 105, 日本語

  • 【腎不全・透析患者さんのよろず健康相談-ビタミン、ミネラル、サプリメントと漢方薬】腸内細菌叢と尿毒症物質
    井上 潤, 星 奈美子, 児玉 裕三
    (株)東京医学社, 2018年11月, 腎と透析, 85(5) (5), 629 - 634, 日本語

  • 16S rRNA遺伝子から見る腸内細菌叢の魅力
    佐々木 建吾, 星 奈美子
    日本生物工学会, 2017年07月, 生物工学会誌, 95(7) (7), 397 - 400, 日本語
    記事・総説・解説・論説等（学術雑誌）

  • 【IBD治療のcritical point-私ならこうする】潰瘍性大腸炎 ステロイド抵抗性の見極めと治療方針 次の治療をどう使い分けるか?
    大井 充, 星 奈美子
    (株)日本メディカルセンター, 2016年05月, 臨床消化器内科, 31(6) (6), 633 - 640, 日本語

  • 抗AIE-75抗体陽性IPEX様症候群を呈したIgA単独欠損症の1女性例
    星 奈美子, 孝橋 道敬, 山入 春香, 具 潤亜, 安冨 栄一郎, 足立 聡一郎, 大塚 崇史, 渡邉 大輔, 大井 充, 吉田 優, 早川 晶, 神保 圭佑, 小林 一郎, 東 健
    日本臨床免疫学会, 2015年09月, 日本臨床免疫学会会誌, 38(4) (4), 321 - 321, 日本語

  • Feasibility of endoscopic submucosal dissection for the treatment of colorectal neoplasms on ileocecal valve
    Tetsuya Yoshizaki, Takashi Toyonaga, Yoshiko Ohara, Fumiaki Kawara, Daisuke Watanabe, Shinwa Tanaka, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    2014年11月, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 29, 44 - 44, 英語
    研究発表ペーパー・要旨（国際会議）

  • Metabolome Analysis-Based Attempt to Discover Therapeutic Agents for Non-Alcoholic Steatohepatitis
    Yoshihiko Terashima, Shin Nishiumi, Namiko Hoshi, Masaru Yoshida, Takeshi Azuma
    2014年05月, GASTROENTEROLOGY, 146(5) (5), S12 - S12, 英語
    研究発表ペーパー・要旨（国際会議）

  • メタボロミクスの現状と炎症/炎症性腸疾患解析への応用
    孝橋 道敬, 西海 信, 大井 充, 塩見 優紀, 吉江 智郎, 星 奈美子, 東 健, 吉田 優
    2014年01月, 炎症と免疫, 22(1) (1), 13 - 16, 日本語
    [招待有り]
    記事・総説・解説・論説等（学術雑誌）

  • Cell Type Specific Role of MyD88 in Commensal-Dependent Colitis
    Namiko Hoshi, Akiko Iwasaki, Ruslan Medzhitov, Takeshi Azuma
    2013年09月, DIGESTIVE DISEASES AND SCIENCES, 58(9) (9), 2437 - 2437, 英語
    研究発表ペーパー・要旨（国際会議）

  • Cell type-specific role of autophagy against Citrobacter rodentium infectious colitis
    Jun Inoue, Namiko Hoshi, Shin Nishiumi, Yoshimi Fujishima, Atsuhiro Masuda, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma
    2013年05月, JOURNAL OF IMMUNOLOGY, 190, 英語
    研究発表ペーパー・要旨（国際会議）

  • Namiko Hoshi, Ruslan Medzhitov
    2012年05月, NATURE MEDICINE, 18(5) (5), 654 - 656, 英語
    その他

■ 書籍等出版物
  • 消化器医のための重要論文240篇
    分担執筆, 168-171, シービーアール, 2019年11月, 日本語, ISBN: 9784908083464

■ 講演・口頭発表等
  • ランチョンセミナー6 機序から見なおすJAK阻害剤
    星 奈美子
    第111回日本消化器病学会総会, 2025年04月

  • Clinical features of pediatric ulcerative colitis with atypical endoscopic findings
    Haruka Miyazaki, Misaki Agawa, Hirotaka Nakamura, Yuki Ito, Norihiro Okamoto, Yuna Ku, Daisuke Watanabe, Namiko Hoshi, Chika Ueda, Atsushi Kondo, Tomoko Horinouchi, Makoto Ooi, Yuzo Kodama
    ECCO2025- 20th Congress of European Crohn's and Colitis Organisation, 2025年02月
    ポスター発表

  • The role of LAT1 in colitis and colitis-associated tumorigenesis
    Yunlong Sui, Norihiro Okamoto, Namiko Hoshi, Yuta Inoue, Takumi Funatsu, Yuna Ku, Makoto Ooi, Daisuke Watanabe, Haruka Miyazaki, Misaki Agawa, Hirotaka Nakamura, Hui Yang, Yuzo Kodama
    ECCO2025- 20th Congress of European Crohn's and Colitis Organisation, 2025年02月
    ポスター発表

  • ランチョンセミナー5 潰瘍性大腸炎におけるJAK阻害薬の役割と可能性
    星 奈美子
    第61回日本消化器免疫学会総会, 2024年12月

  • 日本における潰瘍性大腸炎の治療戦略update
    2024 Digestive Disease Transformation Medicine Forum
    [招待有り]
    口頭発表（招待・特別）

  • マウスモデルを使用した腸管腫瘍におけるアミノ酸トランスポーターLAT1の役割
    Namiko Hoshi, Sui Yunlong, Yuzo Kodama
    2023 Digestive Disease transformation Medicine Forum, 2023年12月
    [招待有り]
    口頭発表（招待・特別）

  • 1. 医療は世界の共通問題：人生一回、小さい自分ができること
    星奈美子
    第215回日本消化器病学会東北支部例会-第170回日本消化器内視鏡学会東北支部例会 合同支部例会, 2023年07月
    [招待有り]
    口頭発表（基調）

  • 潰瘍性大腸炎患者におけるCD4陽性細胞浸潤とベドリズマブの有効性との関連
    宮﨑はる香, 星奈美子, 児玉裕三
    第109回日本消化器病学会総会, 2023年04月
    シンポジウム・ワークショップパネル（公募）

  • Roles of L-Type amino acid transporter1 in the development of intestinal tumors
    Yunlong Sui, Namiko Hoshi, Ryuichi Ohgak, Yuki Ito, Takenori Kotani, Takashi Matozaki, Yuzo Kodama
    30th United European Gastroenterology Week, 2022年10月
    口頭発表（一般）

  • 腸管腫瘍におけるアミノ酸トランスポーターLAT1の役割について
    Yunlong Sui, Namiko Hoshi, Ryuichi Ohgaki, Yuki Ito, Takenori Kotani, Takashi Matozaki, Yuzo Kodama
    第81回日本癌学会, 2022年10月
    口頭発表（一般）

  • 潰瘍性大腸炎における5-アミノサリチル酸不耐（5-ASA不耐）
    星奈美子,岡本典大,宮﨑はる香,徳英里,伊藤裕貴,渡辺大輔,大井充,児玉裕三
    青島消化器病学会 中国ー日本内視鏡シンポジウム2022, 2022年06月
    [招待有り]
    口頭発表（招待・特別）

  • 潰瘍性大腸炎患者における5-ASA製剤不耐増加傾向について：単施設観察研究
    岡本典大,大井充,宮﨑はる香,徳永英里,具潤亜,渡辺大輔,星奈美子,児玉裕三
    第10回アジア炎症性腸疾患学会総会, 2022年06月

  • 腸管腫瘍の発生と細胞増殖におけるL-type amino acid transporter1 の役割とその機序の検討
    星奈美子, 隋雲竜, 児玉裕三
    第108回 日本消化器病学会総会, 2022年04月
    シンポジウム・ワークショップパネル（公募）

  • 炎症性腸疾患の治療選択における内視鏡検査の意義 Nancy Indexを用いた潰瘍性大腸炎患者の再燃予測診断について
    岡本 典大, 大井 充, 具 潤亜, 星 奈美子, 児玉 裕三
    第107回日本消化器内視鏡学会近畿支部例会, 2021年12月
    シンポジウム・ワークショップパネル（公募）

  • 潰瘍性大腸炎における抗インテグリンαvβ6自己抗体の検討
    桒田威, 塩川雅広, 大井充, 星奈美子, 岡部誠, 本澤有介, 山本修司, 山崎大, 宇座徳光, 児玉裕三
    第12回日本炎症性腸疾患学会, 2021年11月
    シンポジウム・ワークショップパネル（公募）

  • 潰瘍性大腸炎の病理学的評価における Nancy Index の有用性について
    岡本 典大, 大井 充, 星 奈美子, 児玉 裕三
    第106回日本消化器内視鏡学会近畿支部例会, 2021年07月
    シンポジウム・ワークショップパネル（公募）

  • 当院における潰瘍性大腸炎での５ASA不耐症の現状について
    岡本典大, 宮崎はる香, 徳永英里, 松本慶, 具潤亜, 竹中春香, 大井充, 星奈美子, 児玉裕三
    第107回日本消化器病学会総会, 2021年04月
    口頭発表（一般）

  • 炎症性腸疾患の免疫学 up to date
    星奈美子
    第210回日本消化器病学会東北支部例会 専門医セミナー, 2021年02月
    [招待有り]
    公開講演，セミナー，チュートリアル，講習，講義等

  • Lipomatous pseudohypertrophy of the pancreasの2症例
    宮﨑はる香, 岡本典大, 徳永英里, 竹中春香, 具潤亜, 大井充, 星奈美子, 児玉裕三
    第114回日本消化器病学会近畿支部例会, 2021年02月
    シンポジウム・ワークショップパネル（公募）

  • 血清可溶性IL-2受容体とIgG値による自己免疫性腸炎に対する6-MP量の最適化
    Asian Organization for Crohn's, Colitis
    第8回アジア炎症性腸疾患学会学術集会, 2020年12月
    ポスター発表

  • CTLA-4欠損症に起因した自己免疫性腸症に対し6-メルカプトプリンが有用であった1例
    岡本典大, 宮崎はる香, 徳永英里, 具潤亜, 竹中春香, 孝橋道敬, 大井充, 星奈美子, 児玉裕三
    第11回日本炎症性腸疾患学会学術集会, 2020年12月
    シンポジウム・ワークショップパネル（公募）

  • 潰瘍性大腸炎のマネージメント
    星奈美子
    第11回日本炎症性腸疾患学会学術集会, 2020年12月
    その他

  • クローン病との鑑別を要した家族性地中海熱の1例
    具 潤亜, 星 奈美子, 大井 充, 竹中 春香, 徳永 英里, 宮崎 はるか, 明本 由衣, 櫻庭 裕丈, 飯田 智哉, 仲瀬 裕志, 児玉 裕三
    日本小腸学会学術集会プログラム・抄録集, 2019年11月, 日本語, 日本小腸学会

  • ベーチェット病に伴う仙腸関節炎に対して抗TNFα阻害薬で治療中に、食道穿通病変と回盲部潰瘍が出現し、内科的治療で治療しえた腸管型ベーチェット病の1例
    能瀬 洋子, 井上 綾華, 上田 洋, 宮崎 はる香, 大井 充, 岡野 隆一, 千藤 荘, 明石 健吾, 大西 輝, 星 奈美子, 三枝 淳, 児玉 裕三, 森信 暁雄
    日本臨床免疫学会総会プログラム・抄録集, 2019年10月, 日本語, 日本臨床免疫学会

  • ステロイドへの反応性が良好であった小腸リンパ管拡張症の1例
    中井 沙紀, 具 潤亜, 上田 千勢, 松本 慶, 竹中 春香, 大井 充, 星 奈美子, 児玉 裕三
    日本消化器病学会近畿支部例会プログラム・抄録集, 2019年10月, 日本語, 日本消化器病学会-近畿支部

  • Pathological intestinal environmental status of ulcerative colitis detected by in vitro human colonic microbiota culture system
    Namiko Hoshi, Kengo Sasaki, Jun Inoue, Daisuke Sasaki, Itsuko Fukuda, Akihiko Kondo, Yuzo Kodama, Ro Osawa
    The 7th annual meeting of Asian Organization for Crohn's & Colitis, 2019年06月
    ポスター発表

  • NUDT15遺伝子R139C多型を背景とし、アザチオプリンによる無顆粒球症を発症した潰瘍性大腸炎の1例
    塚本 祥太, 渡邉 大輔, 大塚 崇史, 大井 充, 阪口 博哉, 具 潤亜, 山入 春香, 阿部 洋文, 迫 智也, 星 奈美子, 吉田 優, 児玉 祐三
    日本消化器病学会近畿支部例会プログラム・抄録集, 2019年02月, 日本語, 日本消化器病学会-近畿支部

  • 「炎症性腸疾患:シームレスなアプローチを目指して」Special situationにおけるコンセンサスとピットフォール 生物学的製剤投与中の炎症性腸疾患患者における妊娠・出産の経験
    大井 充, 星 奈美子, 児玉 裕三, 青山 伸郎
    日本消化管学会雑誌, 2019年02月, 日本語, (一社)日本消化管学会

  • 炎症性腸疾患治療の最前線 当院におけるクローン病に対するウステキヌマブ使用例の検討
    大塚 崇史, 大井 充, 星 奈美子, 児玉 裕三
    日本消化器病学会近畿支部例会プログラム・抄録集, 2019年02月, 日本語, 日本消化器病学会-近畿支部

  • In vitro培養系ヒト腸内細菌叢モデルによる潰瘍性大腸炎患者の代謝プロファイル異常の検出
    佐々木 建吾, 井上 潤, 星 奈美子, 佐々木 大介, 福田 伊津子, 近藤 昭彦, 大澤 朗
    第70回日本生物工学会大会, 2018年09月, 日本語, 関西大学 千里山キャンパス, 国内会議
    ポスター発表

  • Successful detection of dysbiosis and altered short-chain-fatty acids levels in in vitro colonic microbiota culture system using faecal samples of ulcerative colitis
    井上 潤, 佐々木 建吾, 星 奈美子, 佐々木 大介, 近藤 昭彦, 大澤 朗
    13th Congress of ECCO, 2018年02月, 英語, オーストリア, ウィーン, 国際会議
    ポスター発表

  • 複数の腸炎モデルマウスに対する漢方薬青黛の効果の検討
    足立 聡一郎, 星 奈美子, 井上 潤, 安冨 栄一郎, 大塚 崇史, Ramesh Dhakhwa, 王 梓, 孔 玲玲, 渡邉 大輔, 大井 充, 吉田 優
    第8回日本炎症性腸疾患学会 学術集会, 2017年12月, 日本語, 日本炎症性腸疾患学会, 東京, 国内会議
    ポスター発表

  • 潰瘍性大腸炎(UC)に対するInfliximab(IFX)とTacrolimus(TAC)の長期予後の比較検討
    大塚崇史, 大井充, 星奈美子
    第8回日本炎症性腸疾患学会, 2017年12月, 日本語, 日本炎症性腸疾患学会, 東京, 国内会議
    ポスター発表

  • Increased susceptibility to enteropathogenic bacteria by proton pump inhibitors in the murine model of food poisoning
    安冨 栄一郎, 井上 潤, 足立 聡一郎, 大塚 崇史, 渡邉 大輔, 具 潤亜, 山入 春香, 大井 充, 星 奈美子, 福田 真嗣, 吉田 優, 東 健
    25th United European Gastroenterology Week, 2017年10月, 英語, United European Gastroenterology, バルセロナ, スペイン, 国際会議
    ポスター発表

  • 腸内細菌の身体への影響～腸内環境から築く健康～
    星 奈美子
    第6回エビデンスニ基づく統合医療研究会, 2017年09月, 日本語, エビデンスニ基づく統合医療研究会, 神戸, 国内会議
    公開講演，セミナー，チュートリアル，講習，講義等

  • 腸内細菌と炎症性腸疾患
    星 奈美子
    第27回日本サイトメトリー学会, 2017年06月, 日本語, 日本サイトメトリー学会, 神戸, 国内会議
    [招待有り]
    口頭発表（招待・特別）

  • 腸管ベーチェット病および単純性潰瘍における抗TNFα抗体製剤の有効性と内使用的改善度に関する検討
    大塚崇史, 大井充, 星奈美子, 吉田優
    第98回日本消化器内視鏡学会近畿支部例会, 2017年06月, 日本語, 日本消化器内視鏡学会, 神戸, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • Modification of IBD by gut flora recognition and change of intestinal microenvironment
    星 奈美子
    The 6th China-Japan Forum on Endoscopy and The conference of Qingdao Digestive Disease 2017, 2017年06月, 英語, 青島市医師会/青島大学医学部附属病院, 青島, 中国, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • プロトンポンプ阻害薬による腸内環境変化と感染性腸炎への高感受性リスクの検討
    安冨 栄一郎, 星 奈美子, 東 健
    第103回日本消化器病学会総会, 2017年04月, 日本語, 日本消化器病学会, 東京, 国内会議
    シンポジウム・ワークショップパネル（公募）

  • Critical role of MyD88 signaling in CD11c+ cells in progression of intestinal tumor
    星 奈美子, Lesley Pasman, Ruslan Medzhitov
    第44回日本免疫学会, 2015年11月, 日本語, 日本免疫学会, 札幌, 国内会議
    ポスター発表

  • Interactions of Host Cells, Microbiota and Its Metabolites in the Intestinal Tumor
    星 奈美子
    KSBMB International Conference 2015, 2015年05月, 英語, Korean Society for Biochemistry and Molecular Biology, Seoul, Korea, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • Host-commensal interaction: disease and homeostasis in the gut
    星 奈美子
    University of Washington and Kobe University International Joint Symposium, 2014年12月, 英語, University of Washington, Center for Education and Research in Membrane Biology and Medicine, Kobe University Graduate School of Medicine, 神戸, 国際会議
    [招待有り]
    口頭発表（招待・特別）

  • Clinical course after circumferential and sub-circumferential rectal endoscopic submucosal dissection for large rectal neoplasms
    Yoshiko Ohara, Takashi Toyonaga, Shinwa Tanaka, Tetsuya Yoshizaki, Fumiaki Kawara, Tsukasa Ishida, Namiko Hoshi, Yoshinori Morita, Eiji Umegaki, Takeshi Azuma
    UEGW, 2014年10月, 英語, UEGW, ウィーン, オーストリア, 国際会議
    ポスター発表

  • Metabolome Analysis-Based Attempt to Discover Therapeutic Agents for Non-Alcoholic Steatohepatitis
    寺島 禎彦, 西海 信, Namiko Hoshi, Masaru Yoshida, Takeshi Azuma
    Digestive Disease Week 2014, 2014年05月, 英語, American Gastroenterological Association, Chicago, USA, 国際会議
    口頭発表（一般）

  • 炎症性腸疾患モデルマウスにおける細胞特異的MyD88の役割について
    星 奈美子, 岩崎 明子, Ruslan Medzhitov, 東 健
    第21回浜名湖シンポジウム, 2013年12月, 日本語, ゼリア新薬工業株式会社, 浜松, 国内会議
    口頭発表（一般）

  • Cell type-specific role of MyD88 in commensal-dependent colitis
    Namiko Hoshi, Akiko Iwasaki, Ruslan Medzhitov, Takeshi Azuma
    The 7th Japan & US Collaboration Conference in Gastroenterology, 2013年11月, 英語, The American Gastroenterological Association, 東京, 国際会議
    口頭発表（一般）

  • Cell type-specific role of autophagy against Citrobacter rodentium infectious colitis
    Jun Inoue, Namiko Hoshi, Shin Nishiumi, Yoshimi Fujishima, Atsuhiro Masuda, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma
    Immunology 2013, 2013年05月, 英語, The American Association of Immunologist, Hawaii, USA, 国際会議
    ポスター発表

  • ランチョンセミナー6 機序から見なおすJAK阻害剤
    星奈美子
    第111回日本消化器病学会総会, 2025年04月

  • 医療は世界の興津問題ー人生一回、小さい自分ができることー
    星奈美子
    日本消化器病学会東北支部第215回例会 第179回日本消化器内視鏡学会東北支部例会
    [招待有り]
    口頭発表（基調）

■ 共同研究・競争的資金等の研究課題
  • 潰瘍性大腸炎の個別化医療を目指す慢性炎症を呈する自然免疫系エフェクター細胞の同定
    星 奈美子
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2025年04月01日 - 2028年03月31日

  • プロスタグランジン合成酵素に着目したクローン病の新規治療法の開発
    大井 充
    日本学術振興会, 科学研究費助成事業, 基盤研究(C), 神戸大学, 2023年04月 - 2026年03月, 研究分担者

  • 自己抗原の同定に基づいた消化器系難病の病態解明と新しい診療体系の確立
    児玉 裕三, 星 奈美子, 増田 充弘, 上田 佳秀
    日本学術振興会, 科学研究費助成事業, 基盤研究(B), 神戸大学, 2022年04月01日 - 2025年03月31日

  • ロイシンセンシングによる腫瘍発生機序の解明と予防法の開発
    星 奈美子, 森岡 裕香
    日本学術振興会, 科学研究費助成事業, 挑戦的研究(萌芽), 神戸大学, 2023年06月 - 2025年03月, 研究代表者

  • 免疫チェックポイント阻害剤による免疫関連有害事象の病態解明とバイオマーカーの探索
    飛松 和俊, 星 奈美子, 増田 充弘, 児玉 裕三
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2020年04月01日 - 2023年03月31日
    近年、各種の悪性腫瘍に対する免疫チェックポイント阻害剤の使用により、その自己免疫賦活化作用による免疫関連有害事象(immune-related adverse events: irAE)が問題となっている。 消化器内科領域では、irAEの5-10%を占めるirAE大腸炎が問題となっているが、irAE大腸炎は、自己免疫の関与が示唆される炎症性 腸疾患である潰瘍性大腸炎(ulcerative colitis: UC)と類似した内視鏡所見や臨床経過を呈することが明らかとなってきた。UCとirAEには自己免疫機序という 共通の病態が関与しているものと考え、研究を進めている。 申請者の所属している研究室では、UCに特異的な自己抗体Xをすでに確認している。またirAE大腸炎を発症した患者の血清も収集している。ELISA法を用いて、 血清中の自己抗体Xの有無について測定を行っている。またUCの自己抗原Xの類縁抗原を中心とした自己抗体の網羅的な探索についても現在計画中である。 またそれら自己抗体の臨床的意義を確認するため、現在神戸大学で免疫チェックポイント阻害剤を使用した患者の血清を前向きに収集することも開始してい る。モデルマウスを用いた実験については現在準備中である。

  • 腸内アミノ酸調整による腫瘍発生の回避とその機序の解明
    星 奈美子
    日本学術振興会, 科学研究費助成事業 基盤研究(B), 基盤研究(B), 神戸大学, 2020年04月01日 - 2023年03月31日
    大腸癌は世界の癌罹患率第3位で、日本では戦後に増加し、癌死亡率女性1位、男性3位となっている。疫学的に赤肉や加工肉などが増加因子として挙げられるが、その機序は未解明である。遺伝的因子のみでは説明がつかず、環境因子の関わりが要因として推測される。本課題では、食生活と腫瘍の関わりについて科学的根拠を得ることを目的に、肉類に多く含まれるアミノ酸に着目し、アミノ酸が腸管腫瘍の発生や成長に関与するか研究を行う事とした。まず、特定のアミノ酸が役割を担う可能性を考え、20種類のアミノ酸のうち、体内で合成できない必須アミノ酸にまず着目し、必須アミノ酸の中から複数の候補を選択して90％制限食を作成しマウスに与えたところ、他のアミノ酸に比較し、ある一つのアミノ酸制限において、腫瘍発生を回避できることを見出した。この機序を解明するために、このアミノ酸を輸送することが知られているアミノ酸トランスポーターであるL-type amino acid transporter 1 （LAT1)に着目し、腸管上皮特異的にLAT1が欠損するマウスを作成に着手し、腸管組織の形成において、詳細な検討を行うこととした。更に腫瘍モデルと交配して観察をおこなったところ、LAT1欠損マウスにおいて、小腸での腫瘍の成長抑制がおこることが観察される陽性所見を得たこれらのことから、アミノ酸、その輸送体であるトランスポーターが腸管腫瘍形成に非常に重要な役割をになっているというベースのデータを確保したと考えている。

  • 脂肪性肝炎に対するBacteroides菌種の有効性の検討
    矢野 嘉彦, 星 奈美子, 林 祥剛
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2022年03月31日

  • 腸内環境の修飾による大腸癌予防法の開発
    大井 充, 星 奈美子
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 基盤研究(C), 神戸大学, 2019年04月01日 - 2022年03月31日

  • 佐々木 建吾
    学術研究助成基金助成金／基盤研究(C), 2018年04月 - 2021年03月
    競争的資金

  • 星 奈美子
    学術研究助成基金助成金／基盤研究(C), 2017年04月 - 2020年03月, 研究代表者
    競争的資金

  • 東 健
    科学研究費補助金／基盤研究(B), 2016年04月 - 2019年03月
    競争的資金

  • 星 奈美子
    学術研究助成基金助成金／若手研究(B), 2013年04月 - 2016年03月, 研究代表者
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■ 産業財産権
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    特許権

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