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田中 伴典医学部附属病院 病理診断科助教
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びまん性肺疾患の診断・研究を行っています。
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■ 論文- BACKGROUND: Interstitial lung abnormalities (ILA) are CT-detected interstitial abnormalities that may represent early-stage interstitial lung disease (ILD). However, histopathologic correlations remain limited, with previous studies reporting conflicting results. In 2025, the American Thoracic Society (ATS) established criteria defining the boundary between ILA and ILD. This study aimed to investigate the histopathological spectrum of Fleischner-defined ILA, correlate findings with CT features and outcomes, and reclassify cases according to 2025 ATS criteria. METHODS: This retrospective study analyzed 30 consecutive patients who underwent surgical lung biopsy between January 2010 and December 2021. All cases had ILA per Fleischner Society criteria and were reclassified using 2025 ATS criteria. Three pulmonary pathologists evaluated dominant and co-existing histopathological patterns. Two chest radiologists independently assessed CT findings. Overall survival was compared between usual interstitial pneumonia (UIP)-related and non-UIP-related groups using Kaplan-Meier analysis. RESULTS: Twenty patients (66.7 %) were men; mean age was 63.6 ± 6.5 years; 27 (90 %) had fibrotic ILA. The most common dominant pattern was UIP (43.3 %), followed by nonspecific interstitial pneumonia (NSIP) and bronchiolocentric interstitial pneumonia (BIP) (20 % each). Overall, 96.7 % of cases met 2025 ATS criteria for ILD (subclinical ILD). On CT, all UIP and NSIP cases showed reticular opacity and traction bronchiectasis, while BIP typically exhibited branching linear opacities. During median follow-up of 92.1 months, overall survival did not differ significantly between UIP-related and non-UIP-related groups (p = 0.595). CONCLUSIONS: This study of Fleischner-defined ILA, predominantly reclassified as subclinical ILD by 2025 ATS criteria, demonstrates diverse histopathological patterns beyond UIP, including BIP, highlighting pathological heterogeneity.2026年01月, Respiratory investigation, 64(2) (2), 101374 - 101374, 英語, 国際誌研究論文(学術雑誌)
- PURPOSE: To perform comprehensive radiological-pathological correlation in systemic sclerosis-associated interstitial lung disease (SSc-ILD) and identify characteristic findings, including subtle abnormalities potentially representing early-stage CT findings. MATERIAL AND METHODS: This retrospective study included 28 SSc-ILD patients who underwent surgical lung biopsy between July 2008 and July 2018. Two chest radiologists independently reviewed whole-lung high-resolution CT (HRCT) images, with the other two radiologists evaluating biopsy sites. Faint amorphous nodular opacity (FANO) was defined as a small, faint nodular opacity superimposed on amorphous ground-glass opacity (GGO) within 1 cm of the pleural surface, showing a band-like distribution parallel to the pleura. Three pulmonary pathologists performed histological evaluation. Discrepancies were resolved through consensus, with CT-pathologic correlation established through joint radiologist-pathologist review. RESULTS: Twenty-eight patients (mean age, 57 years ± 10; 15 men) were evaluated with 79 biopsy specimens. Nonspecific interstitial pneumonia was the predominant pattern on whole-lung HRCT (21 patients, 75%) and pathology (17 patients, 61%). At biopsy sites, GGO was most frequent (92%), followed by reticulation (84%). Reticulation was accompanied by GGO in nearly all cases, reflecting underlying diffuse fibrotic changes. Reticulation patterns with or without traction bronchiolectasis corresponded to varying fibrosis types, spatial distribution, and architectural destruction severity. Specifically, irregular reticulation with traction bronchiolectasis indicated dense fibrosis with severe destruction, representing UIP-like features. FANO was observed in 18 patients (64%), predominantly in anterolateral upper lobes, and corresponded pathologically to perivenular fibrosis and peribronchiolar metaplasia with or without mucostasis. Longitudinal evaluation (median 32.5 months) in 14 patients showed progression in 71%; half of these showed coalescence into subpleural curvilinear opacities with reticulation. CONCLUSION: SSc-ILD demonstrates predominantly diffuse fibrotic changes. Irregular reticulation with traction bronchiolectasis indicates UIP-like features, potentially identifying patients at risk for progression. FANO, observed most commonly in anterolateral upper lobes, frequently progresses to reticulation on longitudinal follow-up, suggesting potential value for early-stage detection. SSc-ILD demonstrated diffuse fibrotic changes as a characteristic feature, while irregular reticulation with traction bronchiolectasis indicated UIP-like fibrosis with severe architectural destruction. FANO, a newly described finding observed in 64% of cases, was predominantly in anterolateral upper lobes and corresponded to perivenular fibrosis and peribronchiolar metaplasia, representing potential early-stage changes.2025年12月, Japanese journal of radiology, 英語, 国内誌研究論文(学術雑誌)
- European Respiratory Society, 2025年09月, Idiopathic interstitial pneumonias, PA5069 - PA5069研究論文(国際会議プロシーディングス)
- BACKGROUND: The interobserver agreement regarding airway-centered fibrosis (ACF), the key diagnostic feature of fibrotic hypersensitivity pneumonitis (fHP) has not been sufficiently addressed to date. We applied digital image analysis to investigate this issue and extracted histological features of ACF to correlate with fHP diagnosis. METHODS: A total of 111 selected glass slides from 17 fHP and 30 idiopathic pulmonary fibrosis (IPF) were scanned and seven expert pulmonary pathologists were tasked with digital annotation of ACF. Interobserver agreement on annotated ACF was assessed using Fleiss' kappa value. ACF recognized by majority of pathologists (4 or more) were considered as consensus ACF (cACF), and their frequencies were compared between fHP and IPF cases. RESULTS: Fleiss' kappa agreement in ACF recognition was 0.32 among seven pathologists. A significant difference between cryobiopsy and VATS specimens regarding an average ACF count per slide (p = 0.012) was found. The number of cACFs in a single case ranged from 0 to 20 (mean 5.71) for fHP cases and 0 to 13 (mean 1.80) for IPF cases (p = 0.011). When limited to surgical biopsies, the average number of cACF was 10.3 for fHP vs. 1.68 for IPF (p < 0.001). The common characteristic features of cACF in fHP were their confinement to the vicinity of respiratory bronchioles, frequent association with peribronchiolar metaplasia, and mild to moderate lymphocytic infiltration. CONCLUSIONS: The recognition of ACF varies widely among pathologists. We identified common histologic features of ACF in fHP cases, proposing criteria for ACF recognition in fHP.2025年05月, Respiratory investigation, 63(3) (3), 314 - 321, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- ABSTRACT We present a case of pancreatic ductal carcinoma with a microcystic appearance. A 64‐year‐old woman was found to have a pancreatic mass during a routine medical checkup. The tumor was well‐circumscribed and multicystic; thus, she was followed up for suspected serous cystadenoma. However, the tumor gradually enlarged in the following 2.5 years; subsequently, she underwent a Whipple procedure. Grossly, the cut surface of the tumor was honeycomb‐like with small cysts. Histologically, the cysts were ductal structures lined by a relatively bland, cuboidal or columnar epithelium with mildly enlarged nuclei. No intracytoplasmic mucus was observed. The presence of stromal invasion confirmed the diagnosis of ductal carcinoma. KRAS was wild type. Postoperative course was uneventful, with no recurrence to date (followup period: 5.5 years postsurgery). The present case did not meet any known subtypes of pancreatic ductal carcinoma. The tumor resembled a large duct variant, which typically shows a microcystic appearance. However, unlike the present case, the large duct type usually consists of mucus‐rich neoplastic cells. A recent study on cholangiocarcinoma proposed a novel tubulocystic subtype characterized by microcystic neoplastic glands and adenofibromatous stroma, which is morphologically similar to the present case. The present case may correspond to a pancreatic counterpart of tubulocystic cholangiocarcinoma.Wiley, 2025年04月, Pathology International, 75(5) (5), 243 - 246[査読有り]研究論文(学術雑誌)
- (一社)日本呼吸器学会, 2025年03月, 日本呼吸器学会誌, 14(増刊) (増刊), 199 - 199, 日本語
- 2024年12月, Rheumatology (Oxford, England), 63(12) (12), e336-e338, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Springer Science and Business Media LLC, 2024年10月, Cureus[査読有り]研究論文(学術雑誌)
- BACKGROUND: Usual interstitial pneumonia (UIP) cases without honeycombing (possible UIP) included various CT features and was often difficult to diagnose. PURPOSE: This study aimed to classify the cases with possible UIP on CT features using cluster analysis and evaluate the features of subsets of participants and the correlation of prognosis. MATERIALS AND METHODS: The study included 85 patients with possible UIP in the 2011 idiopathic pulmonary fibrosis (IPF) guideline with radiological diagnosis. All cases underwent surgical biopsies and were diagnosed by multidisciplinary discussion (MDD) from the nationwide registry in Japan. The readers evaluated pulmonary opacity, nodules, cysts, and predominant distribution which were reclassified by IPF guidelines in 2018. Additionally, cases were classified into four groups by cluster analysis based on CT findings. The differences in survival among IPF classification and the clusters were evaluated. RESULTS: Cases were diagnosed as IPF (n = 55), NSIP (n = 4), unclassifiable (n = 23), and others (n = 3) by MDD. Cluster analysis revealed 4 clusters by CT features (n = 47, 16, 19 and 3, respectively). Cluster 1 had fewer lesions overall. Cluster 2 have many pure ground-glass opacities and ground-glass opacities with reticulation. Cluster 3 had many reticular opacities and nodules with few lower predominant distributions. Cluster 4 was characterized by peribronchovascular consolidation.The mean survival time of cluster 1 (4518 days) was significantly better than cluster 2, 3, and 4 (1843, 2196, and 1814 days, respectively) (p = 0.03). CONCLUSION: In conclusion, UIP without honeycombing included various CT patterns and MDD diagnoses. Significangly differences in prognosis were observed among clusters classified by CT findings.2024年07月, European journal of radiology, 179, 111651 - 111651, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Abstract Background Herein, we report a case of gastric antrum cancer with multiple invasions to other organs that was completely cured with laparoscopic distal gastrectomy after preoperative chemotherapy in a patient with poor general condition. Case presentation An 80-year-old male patient was diagnosed with anemia during follow-up for cerebral lacunar infarction at another hospital. He was diagnosed with advanced-stage gastric antrum cancer and was referred to our hospital. On esophagogastroduodenoscopy, type 2 advanced-stage gastric cancer was detected at the greater curvature of the antrum, and the biopsy results revealed tubular adenocarcinoma. Contrast-enhanced computed tomography scan revealed multiple invasions to other organs, thick gastric wall with contrast effect, and superior mesenteric vein tumor thrombus. However, there was no evidence of distant metastasis on positron emission tomography/computed tomography scan. The clinical diagnosis was stage IVA gastric cancer. Pancreatoduodenectomy with portal vein resection could be important at this point. However, preoperative chemotherapy with S-1 and oxaliplatin was administered instead of performing extended surgery because the patient had poor general condition (performance status score of 3). The patient received three cycles of preoperative chemotherapy at the hospital along with rehabilitation and nutritional management with oral nutritional supplements. After treatment, the performance status score of the patient improved from 3 to 1. Furthermore, in terms of clinical therapeutic effect, the patient achieved partial response. Hence, laparoscopic distal gastrectomy with D2 lymph node dissection and partial transverse colectomy was performed. After surgery, the patient was admitted for oral intake on postoperative day 6 and was discharged on postoperative day 21. Based on the histopathological examination, gastric cancer had disappeared, and there were no evident malignant findings. Therefore, gastric cancer was classified as grade 3 according to the histological treatment efficacy criteria. The patient did not present with recurrence at 2 years after surgery. Conclusions By actively administering preoperative chemotherapy, minimally invasive radical surgery with maximum preservation of the surrounding organs can be performed for locally far advanced-stage gastric cancer in older patients with poor general condition.Springer Science and Business Media LLC, 2024年06月, Surgical Case Reports, 10(1) (1)[査読有り]研究論文(学術雑誌)
- BACKGROUND AND PURPOSE: Idiopathic dendriform pulmonary ossification (DPO) is mostly asymptomatic, and detected incidentally in lung CT. There have been no reports on the precise CT-pathologic correlation and the prevalence of idiopathic DPO. This study aimed to clarify the histological background and prevalence of idiopathic DPO. MATERIALS AND METHODS: Sixteen patients with histologically confirmed idiopathic DPO (12 men and 4 women; mean age, 38.8 years; range 22-56 years) were identified in a nationwide epidemiological survey. Local HRCT findings of pre-biopsy examinations, such as branching, round, linear structures with or without high attenuation were compared side by side with histological findings. The attenuation of branching, round, and linear structures was classified into three-point levels on bone window images (width, 2500 HU; level, 500 HU). Furthermore, we collected continuous pulmonary CT images of 8111 cases for checking up metastasis from extrathoracic malignancy at a single institution, and evaluated the prevalence of interstitial lung abnormalities (ILAs) and DPO. RESULTS: In all 16 cases, branching (n = 15, 93%), round (n = 5, 31%), or linear (n = 5, 31%) structures were identified, histologically corresponding to dendriform ossification and cicatricial organizing pneumonia (OP)/fibrosis. Histologically, ossification was confirmed in all the 16 patients. However, in two cases, a highly attenuated structure could not be detected on the pre-biopsy CT of the same area. Regarding the prevalence of idiopathic DPO, 283 (3.5%) of 8111 patients had ILAs, of which a total of 26 (0.3% of all cases, 9.2% of ILAs cases) had DPO. CONCLUSION: Idiopathic DPO showed linear or branching structures with or without high attenuation on CT, corresponded to ossification, cicatricial OP/fibrosis. DPO was seen in 9.2% of ILAs cases. Idiopathic DPO is one of pathologic phenotypes of ILAs.2024年05月, Japanese journal of radiology, 英語, 国内誌[査読有り]研究論文(学術雑誌)
- (一社)日本呼吸器学会, 2024年03月, 日本呼吸器学会誌, 13(増刊) (増刊), 365 - 365, 日本語
- Background: When obtaining specimens from pulmonary nodules in TBLB, distinguishing between benign samples and mis-sampling from a tumor presents a challenge. Our objective is to develop a machine-learning-based classifier for TBLB specimens. Methods: Three pathologists assessed six pathological findings, including interface bronchitis/bronchiolitis (IB/B), plasma cell infiltration (PLC), eosinophil infiltration (Eo), lymphoid aggregation (Ly), fibroelastosis (FE), and organizing pneumonia (OP), as potential histologic markers to distinguish between benign and malignant conditions. A total of 251 TBLB cases with defined benign and malignant outcomes based on clinical follow-up were collected and a gradient-boosted decision-tree-based machine learning model (XGBoost) was trained and tested on randomly split training and test sets. Results: Five pathological changes showed independent, mild-to-moderate associations (AUC ranging from 0.58 to 0.75) with benign conditions, with IB/B being the strongest predictor. On the other hand, FE emerged to be the sole indicator of malignant conditions with a mild association (AUC = 0.66). Our model was trained on 200 cases and tested on 51 cases, achieving an AUC of 0.78 for the binary classification of benign vs. malignant on the test set. Conclusion: The machine-learning model developed has the potential to distinguish between benign and malignant conditions in TBLB samples excluding the presence or absence of tumor cells, thereby improving diagnostic accuracy and reducing the burden of repeated sampling procedures for patients.MDPI AG, 2024年02月, Cancers, 16(4) (4), 731 - 731[査読有り]研究論文(学術雑誌)
- Abstract Risk factors of severe coronavirus disease 2019 (COVID-19) have been previously reported; however, histological risk factors have not been defined thus far. The aim of this study was to clarify subclinical hidden interstitial lung disease (ILD) as a risk factor of severe pneumonia associated with COVID-19. We carefully examined autopsied lungs and chest computed tomography scanning (CT) images from patients with COVID-19 for interstitial lesions and then analyzed their relationship with disease severity. Among the autopsy series, subclinical ILD was found in 13/27 cases (48%) in the COVID-19 group, and in contrast, 8/65 (12%) in the control autopsy group (p = 0.0006; Fisher’s exact test). We reviewed CT images from the COVID-19 autopsy cases and verified that subclinical ILD was histologically detectable in the CT images. Then, we retrospectively examined CT images from another series of COVID-19 cases in the Yokohama, Japan area between February–August 2020 for interstitial lesions and analyzed the relationship to the severity of COVID-19 pneumonia. Interstitial lesion was more frequently found in the group with the moderate II/severe disease than in the moderate I/mild disease (severity was evaluated according to the COVID-19 severity classification system of the Ministry of Health, Labor, and Welfare [Japan]) (moderate II/severe, 11/15, 73.3% versus moderate I/mild, 108/245, 44.1%; Fisher exact test, p = 0.0333). In conclusion, it was suggested that subclinical ILD could be an important risk factor for severe COVID-19 pneumonia. A benefit of these findings could be the development of a risk assessment system using high resolution CT images for fatal COVID-19 pneumonia.Springer Science and Business Media LLC, 2023年10月, BMC Pulmonary Medicine, 23(1) (1), 英語[査読有り]研究論文(学術雑誌)
- Elsevier BV, 2023年08月, The American Journal of Pathology[査読有り]研究論文(学術雑誌)
- Wiley, 2023年02月, The Journal of Dermatology, 50(7) (7)[査読有り]研究論文(学術雑誌)
- Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.2023年, PloS one, 18(8) (8), e0290609, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Context.— The accurate identification of different lung adenocarcinoma histologic subtypes is important for determining prognosis but can be challenging because of overlaps in the diagnostic features, leading to considerable interobserver variability. Objective.— To provide an overview of the diagnostic agreement for lung adenocarcinoma subtypes among pathologists and to create a ground truth using the clustering approach for downstream computational applications. Design.— Three sets of lung adenocarcinoma histologic images with different evaluation levels (small patches, areas with relatively uniform histology, and whole slide images) were reviewed by 18 international expert lung pathologists. Each image was classified into one or several lung adenocarcinoma subtypes. Results.— Among the 4702 patches of the first set, 1742 (37%) had an overall consensus among all pathologists. The overall Fleiss κ score for the agreement of all subtypes was 0.58. Using cluster analysis, pathologists were hierarchically grouped into 2 clusters, with κ scores of 0.588 and 0.563 in clusters 1 and 2, respectively. Similar results were obtained for the second and third sets, with fair-to-moderate agreements. Patches from the first 2 sets that obtained the consensus of the 18 pathologists were retrieved to form consensus patches and were regarded as the ground truth of lung adenocarcinoma subtypes. Conclusions.— Our observations highlight discrepancies among experts when assessing lung adenocarcinoma subtypes. However, a subsequent number of consensus patches could be retrieved from each cluster, which can be used as ground truth for the downstream computational pathology applications, with minimal influence from interobserver variability.Archives of Pathology and Laboratory Medicine, 2022年11月, Archives of Pathology & Laboratory Medicine, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Background Adequate tumor tissue is required to make the best treatment choice for non-small cell lung cancer (NSCLC). Transbronchial biopsy (TBB) by endobronchial ultrasonography with a guide sheath (EBUS-GS) is useful to diagnose peripheral lung lesions. The data of tumor cell numbers obtained by two different sizes of GSs is limited. We conducted this study to investigate the utility of a large GS kit to obtain many tumor cells in patients with NSCLC. Methods Patients with a peripheral lung lesion and suspected of NSCLC were prospectively enrolled. They underwent TBB with a 5.9-mm diameter bronchoscope with a large GS. When the lesion was invisible in EBUS, we changed to a thinner bronchoscope and TBB was performed with a small GS. We compared the tumor cell number prospectively obtained with a large GS (prospective large GS group) and those previously obtained with a small GS (small GS cohort). The primary endpoint was the tumor cell number per sample, and we assessed characteristics of lesions that could be obtained by TBB with large GS. Results Biopsy with large GS was performed in 55 of 87 patients (63.2%), and 37 were diagnosed with NSCLC based on histological samples. The number of tumor cells per sample was not different between two groups (658±553 vs. 532±526, estimated difference between two groups with 95% confidence interval (CI); 125 (-125–376), p = 0.32). The sample size of the large GS group was significantly larger than that of the small GS cohort (1.75 mm2 vs. 0.83 mm2, estimated difference with 95% CI; 0.92 (0.60–1.23) mm2, p = 0.00000019). The lesion involving a third or less bronchus generation was predictive factors using large GS. Conclusions The sample size obtained with large GS was significantly larger compared to that obtained with small GS, but there was no significant difference in tumor cell number. The 5.9-mm diameter bronchoscope with large GS can be used for lesions involving a third or less bronchus generation.Public Library of Science (PLoS), 2021年10月, PLOS ONE, 16(10) (10), e0259236 - e0259236, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- OBJECTIVE: To determine whether autonomic dysfunction in neurosarcoidosis is associated with anti-ganglionic acetylcholine receptor (gAChR) antibodies, which are detected in autoimmune autonomic ganglionopathy. METHODS: We retrospectively extracted cases of sarcoidosis from 1787 serum samples of 1,381 patients between 2012 and 2018. Anti-gAChR antibodies against the α3 and β4 subunit were measured by luciferase immunoprecipitation to confirm the clinical features of each case. We summarized literature reviews of neurosarcoidosis with severe dysautonomia to identify relevant clinical features and outcomes. RESULTS: We extracted three new cases of neurosarcoidosis with severe dysautonomia, among which two were positive for anti-gAChR antibodies: Case 1 was positive for antibodies against the β4 subunit, and Case 2 was positive for antibodies against both the α3 and β4 subunits. We reviewed the cases of 15 patients with neurosarcoidosis and severe dysautonomia, including the three cases presented herein. Orthostatic hypotension and orthostatic intolerance were the most common symptoms. Among the various types of neuropathy, small fiber neuropathy (SFN) was the most prevalent, with seven of nine cases exhibiting definite SFN. Six of eight cases had impaired postganglionic fibers, of which the present three cases revealed abnormality of 123I-MIBG myocardial scintigraphy. Of the 11 cases, 10 were responsive to immunotherapy, except one seropositive case (Case 2). CONCLUSIONS: The presence of gAChR antibodies may constitute one of the mechanisms by which dysautonomia arises in neurosarcoidosis.2021年04月, Journal of neurology, 268(11) (11), 4265 - 4279, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- BACKGROUND: Idiopathic non-specific interstitial pneumonia (iNSIP), idiopathic pleuroparenchymal fibroelastosis (iPPFE), and unclassifiable idiopathic interstitial pneumonia (IIP) are IIPs with chronic fibrotic phenotypes, and unlike idiopathic pulmonary fibrosis, they have often been treated with anti-inflammatory drugs, including corticosteroids and immunosuppressants. However, the impact of bronchoalveolar lavage (BAL) lymphocytosis on the effects of anti-inflammatory therapy has never been evaluated. This study aimed to elucidate whether BAL lymphocytosis can be used to predict the efficacy of anti-inflammatory drugs for iNSIP, iPPFE, and unclassifiable IIP. METHODS: Japanese patients diagnosed with iNSIP, iPPFE, and unclassifiable IIP by multidisciplinary discussion were identified using the nationwide registry. Eligible patients were stratified into four groups with and without BAL lymphocytosis and anti-inflammatory therapy to compare overall survival (OS) and changes in lung function. BAL lymphocytosis was defined as a lymphocyte differential count > 15%, and the cut-off was corroborated by survival classification and regression tree analysis. RESULTS: Overall, 186 patients (37 iNSIP, 16 iPPFE, and 133 unclassifiable IIP) were analyzed. Limited to patients treated with anti-inflammatory drugs (n = 123), patients with BAL lymphocytosis had a better prognosis [hazard ratio (HR), 0.26; 95% confidence interval (CI), 0.11-0.63; P = 0.003], higher slope of forced vital capacity (FVC) % predicted for 2 years, and longer OS (log-rank test, P = 0.012) than those without BAL lymphocytosis. On multivariate analysis, BAL lymphocytosis (HR 0.31; 95% CI 0.13-0.75; P = 0.009) was a prognostic factor for OS, along with age and FVC % predicted. Conversely, for patients managed without anti-inflammatory therapy (n = 63), the presence or absence of BAL lymphocytosis had no prognostic value. CONCLUSIONS: BAL lymphocytosis is associated with good outcomes in patients treated with anti-inflammatory drugs, but has no prognostic value when anti-inflammatory drugs are not used. BAL lymphocytosis may provide a predictive biomarker for identifying patients with iNSIP, iPPFE and unclassifiable IIP who are likely to benefit from anti-inflammatory drugs.2021年04月, Respiratory research, 22(1) (1), 115 - 115, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- BACKGROUND: Nonspecific interstitial pneumonia (NSIP) and organizing pneumonia (OP) are major subtypes of idiopathic interstitial pneumonias (IIPs) and closely related to connective tissue diseases (CTDs). "NSIP with OP overlap" is a controversial finding that has recently appeared in the criteria of interstitial pneumonia with autoimmune features (IPAF). However, details of this controversial entity are not well known. OBJECTIVE: To determine the frequency of "NSIP with OP overlap" pattern in IIPs and to identify differences from idiopathic NSIP (iNSIP). METHODS: In 524 patients with interstitial pneumonia from 39 institutes who underwent surgical lung biopsy, 444 were diagnosed as IIPs by a multidisciplinary discussion meeting via a cloud-based integrated database. Among these patients, 44 (9.9%) who had iNSIP and 21 (4.7%) with histopathologically-defined "NSIP with OP overlap" pattern (a pathological NSIP and OP pattern, but without a UIP pattern) were retrospectively studied. RESULTS: Patients with "NSIP with OP overlap" pattern showed a significantly greater extent of consolidation (p < 0.001), more subpleural ground glass attenuation (p = 0.036), and more peripheral + bronchovascular distribution (p = 0.009) on high-resolution computed tomography than those with iNSIP. The incidences of newly-developed CTDs during follow-up was similar between the groups and polymyositis/dermatomyositis was the most frequent CTD in both groups. Nearly half of the patients fulfilled IPAF criteria, but no significant difference was found between iNSIP and "NSIP with OP overlap" pattern (47.7% vs. 42.9, p = 0.712). The incidence of acute exacerbation and the survival rates were similar between the groups. CONCLUSIONS: The incidence of "NSIP with OP overlap" pattern is 4.7% in IIPs. The frequency of newly-developed CTDs during follow-up, mainly polymyositis/dermatomyositis, the frequency of acute exacerbation, and the survival rate in "NSIP with OP overlap" pattern are similar to those of iNSIP.2020年10月, Respiratory medicine, 174, 106201 - 106201, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- BACKGROUND: Pancreatic pleural effusion and ascites are defined as fluid accumulation in the thoracic and abdominal cavity, respectively, due to direct leakage of the pancreatic juice. They usually occur in patients with acute or chronic pancreatitis but are rarely associated with pancreatic neoplasm. We present here an extremely rare case of pancreatic neuroendocrine tumor with stenosis of the main pancreatic duct, leading to pancreatic pleural effusion. CASE PRESENTATION: A 51-year-old man complained of dyspnea. Left-sided pleural effusion was detected on the chest X-ray. Pleural puncture was performed, and the pleural fluid indicated a high amylase content (36,854 IU/L). Hence, the patient was diagnosed with pancreatic pleural effusion. Although no tumor was detected, the computed tomography (CT) scan showed a pseudocyst and dilation of the main pancreatic duct in the pancreatic tail. Magnetic resonance cholangiopancreatography showed a fistula from the pseudocyst into the left thoracic cavity. Endoscopic retrograde pancreatic drainage was attempted; however, it failed due to stenosis in the main pancreatic duct in the pancreatic body. Endoscopic ultrasound revealed a hypoechoic mass measuring 15 × 15 mm in the pancreatic body that was not enhanced in the late phase of contrast perfusion and was thus suspected to be an invasive ductal carcinoma. The patient underwent distal pancreatectomy with splenectomy and the postoperative course was uneventful. Histopathological examination confirmed a neuroendocrine tumor of the pancreas (NET G2). The main pancreatic duct was compressed by the tumor. Increased pressure on the distal pancreatic duct by the tumor might have caused formation of the pseudocyst and pleural effusion. To the best of our knowledge, this is the first case report of pancreatic pleural effusion associated with a neuroendocrine tumor. CONCLUSIONS: Differential diagnosis of a pancreatic neoplasm should be considered, especially when a patient without a history of pancreatitis presents with pleural effusion.2020年09月, Surgical case reports, 6(1) (1), 222 - 222, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- BACKGROUND: Idiopathic pleuroparenchymal fibroelastosis (iPPFE) is a rare interstitial lung disease characterized by unique radiological and pathological findings. However, pathological evaluations are available only in a limited number of patients. Therefore, several clinical diagnostic criteria have been proposed. Nevertheless, the applicability of these criteria has not yet been validated. Moreover, the clinical course of iPPFE and its prognosis have not yet been completely elucidated. METHODS: The present study assessed previously proposed clinical diagnostic criteria by comparing the clinical features between pathologically diagnosed iPPFE (p-iPPFE) and clinically diagnosed iPPFE (c-iPPFE). Subsequently, the clinical features of iPPFE were characterized and compared with those of idiopathic pulmonary fibrosis (IPF, n = 323). RESULTS: Clinical characteristics of c-iPPFE (n = 27) and p-iPPFE (n = 35) were similar. No significant difference was observed in terms of prognosis between c-iPPFE and p-iPPFE. The number of patients with iPPFE (both c-iPPFE and p-iPPFE) who developed lung cancer was significantly lower than that of patients with IPF. However, acute exacerbation (AE) showed similar incidence in patients with iPPFE and IPF. Survival of patients with iPPFE was significantly worse than that of patients with IPF (5-year survival rate: 38.5% vs. 63.5%, p < 0.0001), and the most common cause of death was chronic respiratory failure (73.8%), followed by AE (14.3%). Male gender was the only poor prognostic factor of iPPFE. CONCLUSION: The present study demonstrated efficiency of clinical diagnosis and also revealed clinically important characteristics of iPPFE that should be considered for management of iPPFE.2020年09月, Respiratory medicine, 171, 106078 - 106078, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Recent studies have suggested that in patients with an idiopathic interstitial pneumonia (IIP), a probable usual interstitial pneumonia (UIP) pattern on chest computed tomography (CT) is sufficient to diagnose idiopathic pulmonary fibrosis (IPF) without histopathology. We retrospectively compared the prognosis and time to first acute exacerbation (AE) in IIP patients with a UIP and a probable UIP pattern on initial chest CT. One hundred and sixty IIP patients with a UIP pattern and 242 with a probable UIP pattern were identified. Probable UIP pattern was independently associated with longer survival time (adjusted hazard ratio 0.713, 95% CI 0.536–0.950; p=0.021) and time to first AE (adjusted hazard ratio 0.580, 95% CI 0.389–0.866; p=0.008). In subjects with a probable UIP pattern who underwent surgical lung biopsy, the probability of a histopathological UIP pattern was 83%. After multidisciplinary discussion and the inclusion of longitudinal behaviour, a diagnosis of IPF was made in 66% of cases. In IPF patients, survival time and time to first AE were not associated with CT pattern. Among subjects with a probable UIP pattern, compared to non-IPF patients, survival time and time to first AE were shorter in IPF patients. In conclusion, IIP patients with a probable UIP pattern on initial chest CT had a better prognosis and longer time to first AE than those with a UIP pattern. However, when baseline data and longitudinal behaviour provided a final diagnosis of IPF, CT pattern was not associated with these outcomes. This suggests diagnostic heterogeneity among patients with a probable UIP pattern.European Respiratory Society (ERS), 2020年04月, European Respiratory Journal, 55(4) (4), 1802465 - 1802465[査読有り]研究論文(学術雑誌)
- BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease often accompanied by skeletal muscle wasting. We investigated whether skeletal muscle mass and muscle attenuation on computed tomography (CT) are predictors of mortality in IPF patients, using a nationwide cloud-based database and web-based multidisciplinary discussion (MDD) system. METHODS: IPF patients diagnosed using MDD from April 2009 to March 2014 were included. We analyzed the cross-sectional area (CSA) of the erector spinae muscle (ESMCSA) and the pectoralis muscle (PMCSA), muscle attenuation of the ESM (ESMMA), and PM (PMMA) on single-slice axial CT. Survival probability was assessed using the Kaplan-Meier method and compared by the log-rank test. Multivariate Cox proportional hazards models were used to evaluate the relationship among the ESMCSA, PMCSA, ESMMA, PMMA, clinical parameters, and prognosis. RESULTS: A total of 199 IPF patients were enrolled. Seventy-four patients died during the study period and the most frequent cause was acute exacerbation (13.1%). The group with the lowest quartile of ESMCSA had significantly worse survival than other groups (P = 0.009). Survival rates of the groups with the lowest quartile of PMCSA, lower ESMMA, and lower PMMA did not differ from those of other groups. According to multivariate analysis, ESMCSA < lower quartile was significantly associated with all-cause mortality (hazards ratio, 1.96; P = 0.030), whereas, ESMMA < median, PMCSA < lower quartile, and PMMA < median were not. CONCLUSIONS: Low ESMCSA on CT images may be a strong risk factor for all-cause mortality in IPF patients based on MDD diagnosis.2020年03月, Respiratory investigation, 58(2) (2), 91 - 101, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Purpose: To describe computed tomography (CT) findings of influenza H1N1 virus-associated pneumonia (IH1N1VAP), and to correlate CT findings to pathological ones. Methods: The study included 24 patients with IH1N1VAP. Two observers independently evaluated the presence, distribution, and extent of CT findings. CT features were divided into either classical form (C-form) or non-classical form (NC-form). C-form included: A.) broncho-bronchiolitis and bronchopneumonia type, whereas NC-forms included: B.) diffuse peribronchovascular type, simulating subacute rheumatoid arthritis-associated (RA) interstitial lung disease (ILD) and C.) lower peripheral and/or peribronchovascular type, resembling dermatomyositis-associated ILD and COVID-19 pneumonia. In 10 cases with IH1N1VAP where lung biopsy was performed, CT and pathology findings were correlated. Results: The most common CT findings were ground-glass opacities (24/24, 100 %) and airspace consolidation (23/24, 96 %). C-form was found in 11 (46 %) patients while NC-form in 13 (54 %). Types A, B, and C were seen in 11(46 %), 4 (17 %), and 9 (38 %) patients, respectively. The lung biopsy revealed organizing pneumonia in all patients and 6 patients (60 %) showed incorporated type organizing pneumonia that was common histological findings of rapidly progressive ILD. Conclusion: In almost half of patients of IH1N1VAP, CT images show NC-form pneumonia pattern resembling either acute or subacute RA or dermatomyositis-associated ILD and COVID-19 pneumonia.2020年, European journal of radiology open, 7, 100297 - 100297, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- 2019年08月, Respirology, 英語Acute exacerbations of fibrotic interstitial lung diseases.[査読有り]研究論文(学術雑誌)
- 2019年07月, Internal medicine, 英語Cancer-associated Retinopathy with Neuroendocrine Combined Large-cell Lung Carcinoma and Adenocarcinoma: A Case Report.[査読有り]研究論文(学術雑誌)
- Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was "Unclassifiable" (54%). Histologically, "Unclassifiable" was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and "Unclassifiable" was the commonest pattern radiologically and histologically.2019年05月, Scientific reports, 9(1) (1), 7355 - 7355, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- Multidisciplinary discussion (MDD) requiring close communication between specialists (clinicians, radiologists and pathologists) is the gold standard for the diagnosis of idiopathic interstitial pneumonias (IIPs). However, MDD by specialists is not always feasible because they are often separated by time and location. An online database would facilitate data sharing and MDD. Our aims were to develop a nationwide cloud-based integrated database containing clinical, radiological and pathological data of patients with IIPs along with a web-based MDD system, and to validate the diagnostic utility of web-based MDD in IIPs.Clinical data, high-resolution computed tomography images and lung biopsy slides from patients with IIPs were digitised and uploaded to separate servers to develop a cloud-based integrated database. Web-based MDD was performed using the database and video-conferencing to reach a diagnosis.Clinical, radiological and pathological data of 524 patients in 39 institutions were collected, uploaded and incorporated into the cloud-based integrated database. Subsequently, web-based MDDs with a pulmonologist, radiologist and pathologist using the database and video-conferencing were successfully performed for the 465 cases with adequate data. Overall, the web-based MDD changed the institutional diagnosis in 219 cases (47%). Notably, the MDD diagnosis yielded better prognostic separation among the IIPs than did the institutional diagnosis.This is the first study of developing a nationwide cloud-based integrated database containing clinical, radiological and pathological data for web-based MDD in patients with IIPs. The database and the web-based MDD system that we built made MDD more feasible in practice, potentially increasing accurate diagnosis of IIPs.2019年05月, The European respiratory journal, 53(5) (5), 英語, 国際誌[査読有り]研究論文(学術雑誌)
- (一社)日本病理学会, 2019年04月, 日本病理学会会誌, 108(1) (1), 367 - 367, 日本語胃異物沈着症の2例
- (一社)日本病理学会, 2019年04月, 日本病理学会会誌, 108(1) (1), 440 - 440, 日本語本学の病理学教育へのWhole Slide Imaging導入の現状
- (一社)日本呼吸器学会, 2018年09月, 日本呼吸器学会誌, 7(5) (5), 342 - 346, 日本語胸腔鏡下肺生検で診断した軽症の多中心性キャッスルマン病の1例[査読有り]
- 2018年09月, Archives of Pathology and Laboratory Medicine, 142(9) (9), 1069 - 1079, 英語Update on Rare Idiopathic Interstitial Pneumonias and Rare Histologic Patterns.[査読有り][招待有り]研究論文(学術雑誌)
- Frontiers Media SA, 2018年05月, Frontiers in Immunology, 9, 英語[査読有り]研究論文(学術雑誌)
- OBJECTIVES: Idiopathic interstitial pneumonia (IIP) and connective tissue disease -associated interstitial pneumonia (CTD-IP) are the two most common types of interstitial pneumonia. IIP and CTD-IP share common histological features, yet their clinical management is different. Separation of the two conditions based solely on histology can be challenging, and there are no established criteria. MATERIALS AND METHODS: We selected 105 consecutive cases of IIP (79 usual interstitial pneumonia and 26 non-specific interstitial pneumonia) and 49 cases of CTD-IP for derivation and 32 cases of IIP and 10 cases of CTD-IP for validation. Fourteen histological parameters were evaluated independently by two pathologists for derivation group and graded into 0 to 3. The association between the score for each marker and a diagnosis of CTD was investigated using Fisher's exact test and stepwise logistic regression analysis. A formula for calculating the probability of IIP and CTD-IP was constructed by the markers identified in the regression test with coefficients for each finding. The formula was confirmed using validation case group. RESULTS: Stepwise logistic regression analysis showed that plasmacytosis, lymphoid follicle with germinal center, and airspace fibrin were suggestive of CTD-IP and that fibroblastic foci, smooth muscle hyperplasia, cellular IP, dense perivascular collagen, and fat metaplasia were suggestive of IIP. The formula used to calculate the probabilities based on estimated values for each finding was created, and user-friendly web based app was composed at www.ctdip.com. On the validation study, 30 out of 32 IIP and eight out of 10 CTD-IPs were distinguished correctly by the app (Specificity: 93%, Sensitivity: 80%). CONCLUSIONS: We identified histological markers and derived a practical formula and user-friendly app to distinguish CTD-IPs from IIP.2018年, PloS one, 13(11) (11), e0206186, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- 2017年10月, MOLECULAR NEUROBIOLOGY, 54(8) (8), 6378 - 6390, 英語[査読有り]研究論文(学術雑誌)
- 2017年08月, DIAGNOSTIC PATHOLOGY, 12(1) (1), 62 - 66, 英語[査読有り]研究論文(学術雑誌)
- 2016年12月, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 140(12) (12), 1375 - 1382, 英語[査読有り]研究論文(学術雑誌)
- 2016年12月, CANCER IMMUNOLOGY RESEARCH, 4(12) (12), 1049 - 1060, 英語[査読有り]研究論文(学術雑誌)
- 2016年09月, ARTHRITIS & RHEUMATOLOGY, 68(9) (9), 2256 - 2256, 英語[査読有り]研究論文(学術雑誌)
- Dove Medical Press Ltd., 2016年07月, International Journal of COPD, 11(1) (1), 1521 - 1532, 英語[査読有り]研究論文(学術雑誌)
- Elsevier B.V., 2016年07月, Respiratory Investigation, 54(4) (4), 272 - 279, 英語[査読有り]研究論文(学術雑誌)
- 2016年, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 19 - 26, 英語[査読有り]研究論文(学術雑誌)
- 2016年, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 11, 1521 - 1532, 英語[査読有り]研究論文(学術雑誌)
- PURPOSE: Pulmonary emphysema is the pathological prototype of chronic obstructive pulmonary disease and is also associated with other lung diseases. We considered that observation with different approaches may provide new insights for the pathogenesis of emphysema. PATIENTS AND METHODS: We reviewed tissue blocks of the lungs of 25 cases with/without emphysema and applied a three-dimensional observation method to the blocks. Based on the three-dimensional characteristics of the alveolar structure, we considered one face of the alveolar polyhedron as a structural unit of alveoli and called it a framework unit (FU). We categorized FUs based on their morphological characteristics and counted their number to evaluate the destructive changes in alveoli. We also evaluated the number and the area of pores of Kohn in FUs. We performed linear regression analysis to estimate the effect of these data on pulmonary function tests. RESULTS: In multivariable regression analysis, a decrease in the number of FUs without an alveolar wall led to a significant decrease in the diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO per unit alveolar volume, and an increase in the area of pores of Kohn had a significant effect on an increase in residual capacity. CONCLUSION: A breakdown in the lung framework and an increase in pores of Kohn are associated with a decrease in DLCO and DLCO per unit alveolar volume with/without emphysema.2016年, International journal of chronic obstructive pulmonary disease, 11, 2287 - 2294, 英語, 国際誌[査読有り]研究論文(学術雑誌)
- 2015年11月, JOURNAL OF THORACIC IMAGING, 30(6) (6), W76 - W79, 英語[査読有り]研究論文(学術雑誌)
- Dove Medical Press Ltd., 2015年07月, International Journal of COPD, 10, 1299 - 1303, 英語[査読有り]研究論文(学術雑誌)
- 2015年03月, EUROPEAN JOURNAL OF RADIOLOGY, 84(3) (3), 542 - 546, 英語[査読有り]研究論文(学術雑誌)
- 2015年03月, RESPIRATORY MEDICINE, 109(3) (3), 389 - 396, 英語[査読有り]研究論文(学術雑誌)
- 2015年, INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 10, 1299 - 1303, 英語[査読有り]研究論文(学術雑誌)
- BioMed Central Ltd., 2014年05月, BMC Clinical Pathology, 14(1) (1), 23, 英語[査読有り]研究論文(学術雑誌)
- 2014年03月, PATHOLOGY INTERNATIONAL, 64(3) (3), 148 - 150, 英語[査読有り]
- 2014年01月, EUROPEAN JOURNAL OF RADIOLOGY, 83(1) (1), 20 - 26, 英語[査読有り]研究論文(学術雑誌)
- 2013年02月, Pathology International, 63(2) (2), 108 - 112, 英語[査読有り]研究論文(学術雑誌)
- 2013年02月, RESPIROLOGY, 18(2) (2), 348 - 353, 英語[査読有り]研究論文(学術雑誌)
- 2013年, BioMed Research International, 2013, 157838, 英語[査読有り]研究論文(学術雑誌)
- 2012年12月, RESPIRATORY MEDICINE, 106(12) (12), 1765 - 1770, 英語[査読有り]研究論文(学術雑誌)
- 2012年11月, ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 136(11) (11), 1377 - 1384, 英語[査読有り]研究論文(学術雑誌)
- 2012年11月, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 10(11) (11), A24 - A24, 英語[査読有り]
- 2012年01月, JOURNAL OF CLINICAL PATHOLOGY, 65(1) (1), 51 - 57, 英語[査読有り]研究論文(学術雑誌)
- 2011年12月, Respiratory medicine, 105(12) (12), 1931 - 1938, 英語[査読有り]研究論文(学術雑誌)
- 2008年04月, PATHOLOGY INTERNATIONAL, 58(4) (4), 239 - 243, 英語[査読有り]研究論文(学術雑誌)
- 2007年04月, PATHOLOGY INTERNATIONAL, 57(4) (4), 213 - 218, 英語[査読有り]研究論文(学術雑誌)
- 2025年, 日本病理学会会誌, 114(1) (1)IPFガイドライン病理診断指標標準化の試み
- 2025年, 日本呼吸器学会誌(Web), 14経気管支クライオバイオプシー検体における病理診断の標準化研究
- 2024年, 日本呼吸器学会誌(Web), 13線維性過敏性肺炎と膠原病合併例に関する研究:第13回大阪呼吸器シンポジウム報告
- 2024年, 日本呼吸器学会誌(Web), 13画像的にI-PPFEとの鑑別が困難であった線維性過敏性肺炎;『第14回大阪呼吸器シンポジウム』報告
- (株)文光堂, 2023年04月, 病理と臨床, 41(臨増) (臨増), 13 - 13, 日本語
- (株)文光堂, 2023年04月, 病理と臨床, 41(臨増) (臨増), 14 - 14, 日本語
- (NPO)日本呼吸器内視鏡学会, 2023年03月, 気管支学, 45(2) (2), 164 - 164, 日本語
- 日本画像医学会, 2023年02月, Japanese Journal of Diagnostic Imaging, 41(増刊) (増刊), 79 - 79, 日本語呼吸器 IP合併肺がん手術後の急性増悪 間質性肺炎合併肺がん術後急性増悪を病理から考える
- (NPO)日本肺癌学会, 2022年10月, 肺癌, 62(5) (5), 444 - 444, 日本語進行肺扁平上皮癌の治療経過中に良性の多発リンパ節腫大と再考し切除した1例
- (公社)日本皮膚科学会, 2022年03月, 日本皮膚科学会雑誌, 132(3) (3), 507 - 507, 日本語ベキサロテン内服と全身皮膚電子線照射療法の併用が奏効したCD4陰性CD8陰性皮膚T細胞リンパ腫の1例
- (一社)日本病理学会, 2022年03月, 日本病理学会会誌, 111(1) (1), 161 - 161, 日本語病理解剖における間質性肺炎診断 剖検での間質性肺炎症例におけるCPCの論点
- (一社)日本病理学会, 2022年03月, 日本病理学会会誌, 111(1) (1), 322 - 322, 日本語過敏性肺炎における気道中心性線維化(ACF)の一致度
- (公社)日本臨床細胞学会, 2021年10月, 日本臨床細胞学会雑誌, 60(Suppl.2) (Suppl.2), 580 - 580, 日本語
- (公社)日本臨床細胞学会, 2021年05月, 日本臨床細胞学会雑誌, 60(Suppl.1) (Suppl.1), 138 - 138, 日本語
- (一社)日本呼吸器学会, 2021年04月, 日本呼吸器学会誌, 10(増刊) (増刊), 225 - 225, 日本語
- (一社)日本病理学会, 2021年03月, 日本病理学会会誌, 110(1) (1), 169 - 169, 日本語間質性肺炎のガイドライン診断 特発性肺線維症のガイドライン診断
- (一社)日本病理学会, 2021年03月, 日本病理学会会誌, 110(1) (1), 264 - 264, 日本語コロナ禍における2つの独立ラインを用いたデジタルリモートカンファレンスの有用性
- (一社)日本病理学会, 2021年03月, 日本病理学会会誌, 110(1) (1), 293 - 293, 英語局所的に肺線維性瘢痕に似た通常型間質性肺炎パターン(Localized Lung Fibrotic Scar mimicking Usual Interstitial Pneumonia like Pattern)
- (一社)日本病理学会, 2021年03月, 日本病理学会会誌, 110(1) (1), 296 - 296, 日本語局所的にMTAP lossとp16ホモ欠失が見られた胸膜mesothelioma in situの1症例
- (一社)日本病理学会, 2021年03月, 日本病理学会会誌, 110(1) (1), 316 - 316, 日本語絨毛癌成分を伴う浸潤性膵管癌の一例
- (公社)日本臨床細胞学会, 2020年11月, 日本臨床細胞学会雑誌, 59(Suppl.2) (Suppl.2), 455 - 455, 日本語
- (公社)日本臨床細胞学会, 2020年11月, 日本臨床細胞学会雑誌, 59(Suppl.2) (Suppl.2), 455 - 455, 日本語中皮腫診断におけるBAP1・MTAP等を用いた良悪判定の実際と問題点 中皮腫診断におけるBAP1・MTAPの免疫組織化学 標本作製法および染色法による影響
- 2020年09月, EUROPEAN RESPIRATORY JOURNAL, 56, 英語研究発表ペーパー・要旨(国際会議)
- (一社)日本呼吸器学会, 2020年08月, 日本呼吸器学会誌, 9(増刊) (増刊), 201 - 201, 日本語
- (一社)日本呼吸器学会, 2020年08月, 日本呼吸器学会誌, 9(増刊) (増刊), 201 - 201, 日本語
- (NPO)日本肺癌学会, 2020年04月, 肺癌, 60(2) (2), 154 - 155, 日本語
- (一社)日本病理学会, 2020年03月, 日本病理学会会誌, 109(1) (1), 419 - 419, 英語嚢胞性病変を伴う肺硝子化肉芽腫の1症例(A Case of Pulmonary Hyalinizing Granulomas with Cystic Lesion)
- (株)メジカルビュー社, 2019年07月, 臨床画像, 35(7) (7), 830 - 835, 日本語
- (一社)日本病理学会, 2019年04月, 日本病理学会会誌, 108(1) (1), 367 - 367, 日本語胃異物沈着症の2例
- (一社)日本病理学会, 2019年04月, 日本病理学会会誌, 108(1) (1), 440 - 440, 日本語本学の病理学教育へのWhole Slide Imaging導入の現状
- (一社)日本呼吸器学会, 2018年09月, 日本呼吸器学会誌, 7(5) (5), 342 - 346, 日本語
- (公社)日本皮膚科学会, 2018年05月, 日本皮膚科学会雑誌, 128(6) (6), 1357 - 1357, 日本語皮膚粘液癌の1例
- (一社)日本小児外科学会, 2018年04月, 日本小児外科学会雑誌, 54(2) (2), 359 - 359, 日本語左全肺に病変を認めたCPAMに対し待機的に左肺全摘術を施行した1例
- (一財)日本消化器病学会, 2018年04月, 日本消化器病学会雑誌, 115(臨増総会) (臨増総会), A395 - A395, 日本語膵体部の膵神経内分泌腫瘍に合併した膵性胸水の一例
- (一社)日本病理学会, 2018年04月, 日本病理学会会誌, 107(1) (1), 501 - 501, 日本語乳癌術後の拘束型心筋症の1剖検例
- (一社)日本病理学会, 2018年04月, 日本病理学会会誌, 107(1) (1), 501 - 501, 日本語乳癌術後の拘束型心筋症の1剖検例
- (一財)日本消化器病学会, 2018年03月, 日本消化器病学会雑誌, 115(臨増総会) (臨増総会), A395 - A395, 日本語膵体部の膵神経内分泌腫瘍に合併した膵性胸水の一例
- 2018年02月, 臨床画像, 34(2) (2), 186 - 194, 日本語【間質性肺炎の診断 Up to Date】 急性・亜急性経過の間質性肺炎に対するMDD診断 病理医の立場から[招待有り]記事・総説・解説・論説等(学術雑誌)
- (NPO)日本肺癌学会, 2017年06月, 肺癌, 57(3) (3), 255 - 256, 日本語MTX長期投与で発症したMTX関連リンパ増殖性疾患の1例
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 372 - 372, 日本語線毛性粘液結節性乳頭状腫瘍の2症例
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 378 - 378, 日本語炭酸ランタン療法中に生じた胃粘膜内ランタン沈着の経時的変化
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 410 - 410, 英語肺の繊毛性粘液結節性乳頭状腫瘍を推進する変異の発見(Discovering the driver mutations in ciliated muconodular papillary tumors of the Lung)
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 410 - 410, 英語肺大細胞がんのNGS(NGS analysis of pulmonary large cell carcinoma)
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 428 - 428, 日本語脂肪組織への進展を認め、悪性中皮腫との鑑別が問題となった胸膜Adenomatoid tumorの1例
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 378 - 378, 日本語炭酸ランタン療法中に生じた胃粘膜内ランタン沈着の経時的変化
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 428 - 428, 日本語脂肪組織への進展を認め、悪性中皮腫との鑑別が問題となった胸膜Adenomatoid tumorの1例
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 410 - 410, 英語NGS analysis of pulmonary large cell carcinoma(和訳中)
- (一社)日本病理学会, 2017年03月, 日本病理学会会誌, 106(1) (1), 410 - 410, 英語Discovering the driver mutations in ciliated muconodular papillary tumors of the Lung(和訳中)
- (公社)日本医学放射線学会, 2017年02月, Japanese Journal of Radiology, 35(Suppl.) (Suppl.), 89 - 89, 日本語陰嚢内及び後腹膜に進展する脱分化型脂肪肉腫の1例
- 医歯薬出版(株), 2017年02月, 医学のあゆみ, 260(8) (8), 653 - 656, 日本語【間質性肺炎のMDD(multi-disciplinary discussion)】 病理医からみた間質性肺炎のMDD診断[招待有り]
- (株)学研メディカル秀潤社, 2016年06月, 画像診断, 36(8) (8), 754 - 766, 日本語
- (公社)日本婦人科腫瘍学会, 2016年06月, 日本婦人科腫瘍学会雑誌, 34(3) (3), 427 - 427, 日本語子宮粘膜下筋腫あるいは内膜ポリープの診断で子宮鏡下手術を行い、術後に子宮内膜癌と診断した5例
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 355 - 355, 英語2011年ATS/ERS/JRS/ALATのIPFガイドラインを用いた診断一致率の検討(Inter-Observer Agreement of Usual Interstitial Pneumonia Diagnosis Correlated with Patient Outcome)
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 357 - 357, 英語中枢神経原発リンパ腫におけるPD-1発現の検討(Programmed cell death-1(PD-1) expression in primary central nervous system lymphoma(PCNSL))
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 371 - 371, 英語生検試料の病理学的診断のための全スライド画像の検証(Validation of Whole slide imaging for pathological diagnosis in biopsy specimen)
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 388 - 389, 英語急性線維素性器質化肺炎とランゲルハンス細胞組織球増殖症が併発した1症例(A case of combined acute fibrinous and organizing pneumonia and Langerhans cell histiocytosis)
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 499 - 499, 英語成人T細胞白血病・リンパ腫(ATLL)におけるPD-1の発現(The expression of Programmed death-1(PD-1) in Adult T-cell leukemia/lymphoma(ATLL))
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 585 - 585, 英語扁平上皮化生 通常型間質性肺炎における急性増悪の組織学的特徴と予後不良因子(Squamous metaplasia: Factor of acute exacerbation and poor prognosis in usual interstitial pneumonia)
- (一社)日本病理学会, 2016年04月, 日本病理学会会誌, 105(1) (1), 589 - 589, 英語肺腺癌の微小乳頭構造とspread through air space(STAS)に関する3D組織学的分析(Micropapillary structure of lung adenocarcinoma and spread through air space(STAS) in 3D histology)
- (NPO)日本CT検診学会, 2016年02月, CT検診, 23(1) (1), 16 - 16, 日本語CTで発見された肺結節の判定基準と経過観察 長崎県における多施設共同研究
- (公社)日本超音波医学会, 2016年01月, 超音波医学, 43(1) (1), 163 - 164, 日本語肝血管筋脂肪腫の1例
- 2016年, 間質性肺疾患研究会討議録, 90th上肺優位の間質性肺炎症例の検討
- 日本臨床外科学会, 2015年10月, 日本臨床外科学会雑誌, 76(増刊) (増刊), 797 - 797, 日本語
- 日本内分泌外科学会・日本甲状腺外科学会, 2015年09月, 日本内分泌・甲状腺外科学会雑誌, 32(Suppl.2) (Suppl.2), S273 - S273, 日本語呼吸困難で術前に気管挿管を要した巨大バセドウ氏病の1例
- 日本胆道学会, 2015年08月, 胆道, 29(3) (3), 653 - 653, 日本語NBI併用拡大内視鏡観察にて観察し得た肝門部十二指腸球部吻合術後胆管に発症した早期胆管癌の1例
- (一社)日本小児血液・がん学会, 2015年08月, 日本小児血液・がん学会雑誌, 52(2) (2), 193 - 193, 日本語4ヵ月間で急速に増大した後腹膜奇形腫の1例
- (一社)日本乳癌学会, 2015年07月, 日本乳癌学会総会プログラム抄録集, 23回, 704 - 704, 日本語乳腺線維腺腫に隣接した粗大石灰化を伴う粘液癌の一例
- (一社)日本核医学会, 2015年05月, 核医学, 52(2) (2), 76 - 76, 日本語FDG-PET/CTが転移性脊椎腫瘍とSAPHO症候群の鑑別に有用であった一例
- (一社)日本呼吸器学会, 2015年03月, 日本呼吸器学会誌, 4(増刊) (増刊), 163 - 163, 日本語
- (一社)日本病理学会, 2015年03月, 日本病理学会会誌, 104(1) (1), 311 - 311, 英語顕微鏡的蜂巣肺の診断一致率及び臨床的意義の検討(Interobserver agreement and clinical meaning of microscopic honeycomb in the cases of IPF)
- (一社)日本病理学会, 2015年03月, 日本病理学会会誌, 104(1) (1), 311 - 311, 英語瘢痕性の器質性肺炎の臨床的、放射線学的、および病理学的特徴(Clinical-radiological-pathological features of scarring organizing pneumonia)
- (一社)日本病理学会, 2015年03月, 日本病理学会会誌, 104(1) (1), 511 - 511, 英語三次元の病理学的な画像再構成から明らかになった肺の最小ユニットと肺気腫の初期イベント(3D pathology construction reveals the minimal unit of the lung and the initial event of emphysema)
- (一社)日本病理学会, 2015年03月, 日本病理学会会誌, 104(1) (1), 512 - 512, 英語慢性過敏性肺炎の特異的病理学的所見の同定(Identification of Specific Histopayhological Findings in Chronic Hypersensitivity Pneumonitis)
- (一社)日本病理学会, 2015年03月, 日本病理学会会誌, 104(1) (1), 512 - 512, 英語特発性間質性肺炎と膠原病関連性間質性肺炎の病理組織学的鑑別診断(Histological Findings Specific for Connective Tissue Disease Associated Interstitial Pneumonia)
- 2015年02月, LABORATORY INVESTIGATION, 95, 493A - 494A, 英語3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema研究発表ペーパー・要旨(国際会議)
- 2015年02月, MODERN PATHOLOGY, 28, 493A - 494A, 英語3D Pathology Construction Reveals Framework Structure of the Lung and Increase of Pores of Kohn as an Initial Event of Emphysema研究発表ペーパー・要旨(国際会議)
- 2015年02月, LABORATORY INVESTIGATION, 95, 475A - 475A, 英語Histological Difference Between Idiopathic Interstitial Pneumonias and Connective Tissue Disease-Associated Interstitial Pneumonias研究発表ペーパー・要旨(国際会議)
- 2015年02月, MODERN PATHOLOGY, 28, 475A - 475A, 英語Histological Difference Between Idiopathic Interstitial Pneumonias and Connective Tissue Disease-Associated Interstitial Pneumonias研究発表ペーパー・要旨(国際会議)
- 2015年, 日本胸腺研究会プログラム・抄録集, 34th胸腺原発MALTリンパ腫の1切除例
- 2015年, びまん性肺疾患に関する調査研究 平成26年度 研究報告書, 103‐108, 日本語びまん性肺疾患に関する調査研究班 2011年ATS/ERS/JRS/ALATのIPFガイドラインにおける病理診断一致率の検討
- (NPO)日本肺癌学会, 2014年10月, 肺癌, 54(5) (5), 433 - 433, 日本語肺癌背景肺におけるMuc5B発現
- (公社)日本医学放射線学会, 2014年09月, 日本医学放射線学会秋季臨床大会抄録集, 50回, S707 - S708, 日本語肺グロームス腫瘍の1例
- (公社)日本医学放射線学会, 2014年09月, 日本医学放射線学会秋季臨床大会抄録集, 50回, S714 - S714, 日本語多発結節影を呈したCaplan症候群の1例
- (一社)日本神経学会, 2014年06月, 臨床神経学, 54(6) (6), 528 - 528, 日本語
- (NPO)日本呼吸器内視鏡学会, 2014年05月, 気管支学, 36(3) (3), 319 - 319, 日本語
- (株)学研メディカル秀潤社, 2014年05月, 画像診断, 34(7) (7), 786 - 797, 日本語
- (公社)日本臨床細胞学会, 2014年04月, 日本臨床細胞学会雑誌, 53(Suppl.1) (Suppl.1), 215 - 215, 日本語甲状腺の腺腫様結節と濾胞性腫瘍における細胞学的鑑別因子の同定研究
- (NPO)日本肺癌学会, 2014年04月, 肺癌, 54(2) (2), 108 - 109, 日本語肺門部Glomus腫瘍の1例
- (一社)日本病理学会, 2014年03月, 日本病理学会会誌, 103(1) (1), 205 - 205, 英語P-index UIP患者における予後予測のための簡易で有効な組織学的ツール(P-index: A Simple and Validated Histological Tool for Predicting Prognosis in UIP patients)
- (一社)日本病理学会, 2014年03月, 日本病理学会会誌, 103(1) (1), 206 - 206, 英語弾力線維症によるperilobular margination 通常型間質性肺炎の堅牢な組織学的マーカ(Perilobular Margination by Elastosis: A Robust Histologic Marker of Usual Interstitial Pneumonia)
- 2014年, 肺癌(Web), 54(2) (2)肺門部Glomus腫瘍の1例
- 日本サルコイドーシス, 2013年10月, 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 33(1-2) (1-2), 23 - 26, 日本語[招待有り]
- (公社)日本臨床細胞学会, 2013年05月, 日本臨床細胞学会雑誌, 52(Suppl.1) (Suppl.1), 226 - 226, 日本語尿細胞診で診断された膀胱原発悪性黒色腫の一例
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 317 - 317, 日本語病理診断標準化を目的としたウェブフリー診断補助ソフトの構築 肺線維症の場合
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 370 - 370, 日本語筋上皮成分の小壊死巣や高い増殖能を示す腺筋上皮腫の一例
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 383 - 383, 日本語早期食道癌におけるリン酸化eIF4E発現の検討
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 394 - 394, 日本語再発を来した脊髄神経の混成シュワン細胞腫・神経周膜腫
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 410 - 410, 日本語上皮内成分を確認できず診断に苦慮した腎の形質細胞様型浸潤性尿路上皮癌の1例
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 410 - 410, 日本語高齢者に偶発的に発見された腎mixed epithelial and stromal tumorの一例
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 423 - 423, 英語肺胞蛋白症様変化は特発性肺線維症で一般的な反応である(Pulmonary Alveolar Proteinosis Like Change Is a Common Reaction in Idiopathic Pulmonary Fibrosis)
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 424 - 424, 英語肺線維症におけるProSP-Cの発現量低下は病態の進行を示す組織学的な指標である(Lower expression of ProSP-C in pulmonary fibrosis As a Histological Marker of Disease progression)
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 424 - 424, 日本語肺気腫と喫煙の肺線維症との関連性(Association of emphysema and Tobacco smoking with pulmonary fibrosis)
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 425 - 425, 日本語Ciliated muconodular papillary tumor of the lungの免疫組織化学的検討
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 425 - 425, 日本語肺病変先行型結合組織疾患の病理学的特徴(Pathological features of lung dominant connective tissue disease)
- (一社)日本病理学会, 2013年04月, 日本病理学会会誌, 102(1) (1), 498 - 498, 英語間質性肺疾患における細気管支周囲異形成の有病率(Prevalence of Peribronchiolar Metaplasia In The Interstitial Lung Disease)
- (一社)日本呼吸器学会, 2013年03月, 日本呼吸器学会誌, 2(増刊) (増刊), 28 - 28, 日本語疾患と運動時低酸素血症 運動時低酸素血症を来す疾患の病理診断
- (公社)日本医学放射線学会, 2013年02月, Japanese Journal of Radiology, 31(Suppl.I) (Suppl.I), 41 - 41, 日本語Neurolymphomatosisの1例
- (公社)日本医学放射線学会, 2013年02月, 日本医学放射線学会学術集会抄録集, 72回, S212 - S212, 日本語喫煙者における線維化を伴う肺気腫とIPFの比較評価
- (NPO)日本肺癌学会, 2012年10月, 肺癌, 52(6) (6), 987 - 987, 日本語気道狭窄を来した扁平上皮癌の1例
- (NPO)日本肺癌学会, 2012年10月, 肺癌, 52(6) (6), 988 - 988, 日本語前縦隔悪性腫瘍の1例
- 日本サルコイドーシス, 2012年09月, 日本サルコイドーシス/肉芽腫性疾患学会雑誌, 32(サプリメント号) (サプリメント号), 19 - 19, 日本語サルコイドーシス/肉芽腫性肺疾患の画像・病理・呼吸機能 サルコイドーシス・肉芽腫性肺疾患の病理
- (一社)日本病理学会, 2012年09月, 日本病理学会会誌, 101(2) (2), 28 - 28, 日本語医療の現場に役立つデジタルパソロジー 病理診断標準化を目的としたウェブフリー診断補助ソフトの構築 間質性肺炎における試み
- (一社)日本病理学会, 2012年09月, 日本病理学会会誌, 101(2) (2), 51 - 51, 日本語肺癌を合併した喫煙関連肺疾患の1剖検例
- (NPO)日本呼吸器内視鏡学会, 2012年07月, 気管支学, 34(4) (4), 407 - 408, 日本語
- (一社)日本呼吸器学会, 2012年03月, 日本呼吸器学会誌, 1(増刊) (増刊), 290 - 290, 日本語抗IL-6受容体抗体治療中に肺アスペルギルス症が出現した関節リウマチの一例
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 257 - 257, 英語スパイラルアレイは肺癌の生存解析における組織不均一性をカバーする(Spiral Array Covers Tissue Heterogeneity for Survival Analysis of Lung Cancer)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 279 - 279, 英語非特異的間質性肺炎の急速進行例 独特な症例なのか?(Rapidly progressing cases of Nonspecific Interstitial Pneumonia: Are they unique?)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 393 - 393, 英語肉芽腫と巨細胞を有する通常型間質性肺炎 臨床病理学的特徴(Usual Interstitial Pneumonia with Granuloma and Giant Cells: Clinicopathological Features)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 429 - 429, 日本語病理用スパイラルアレイのWhole Block、CNB、高密度アレイへの応用(Application of the Spiral Array for Pathology, to use of Whole Block, CNB, and High-Density Array)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 437 - 437, 英語肺の中枢型扁平上皮癌と末梢型扁平上皮癌の比較(Comparison of Central vs. Peripheral Squamous Cell Carcinoma of the Lung)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 440 - 440, 英語自然気胸内に隠れた小さな気道疾患(Small Airway Disease Hidden Inside Spontaneous Pneumothorax)
- (一社)日本病理学会, 2012年03月, 日本病理学会会誌, 101(1) (1), 440 - 440, 英語弾性線維症は慢性間質性肺炎における組織学的予後因子か?(An Elastosis Is a Histologic Prognostic Factor in Chronic Interstitial Pneumonia)
- (公社)日本臨床細胞学会, 2012年03月, 日本臨床細胞学会雑誌, 51(Suppl.1) (Suppl.1), 379 - 379, 日本語卵巣の「微小乳頭状パターンを伴う漿液性境界悪性腫瘍」の一例
- 日本毒性病理学会, 2012年02月, 日本毒性病理学会講演要旨集, 28回, 83 - 83, 英語スパイラルアレイによる肺がんの予後検討 Ki67について(Application of Spiral Array to Survival Analysis of Lung Cancer: Tissue Heterogeneity of Ki67 Matters)
- (株)医学書院, 2011年11月, 検査と技術, 39(12) (12), 1115 - 1118, 日本語
- 日本医学会, 2011年10月, 日本医学会総会会誌, 28回(I) (I), 205 - 205, 日本語びまん性肺疾患 研究と診療の新たな展開 びまん性肺疾患の病理診断
- (公社)日本臨床細胞学会, 2011年09月, 日本臨床細胞学会雑誌, 50(Suppl.2) (Suppl.2), 476 - 476, 日本語呼吸器細胞診TECHNO-COLLEGE LBC標本を用いたカクテル抗体免疫染色による肺癌組織型診断の検討
- (有)科学評論社, 2011年06月, 呼吸器内科, 19(6) (6), 533 - 539, 日本語【特発性肺線維症(IPF)】 特発性肺線維症(IPF)の病理診断
- (株)メジカルビュー社, 2011年04月, 臨床画像, 27(4) (4), 477 - 492, 日本語【びまん性肺疾患 これだけは押さえておきたいHRCT診断の基本】びまん性肺疾患のHRCT 嚢胞性病変(低吸収性病変)の基本
- (一社)日本病理学会, 2011年03月, 日本病理学会会誌, 100(1) (1), 358 - 358, 英語形態保持能が改善した新規ハイスループット法としてのスパイラルアレイ法(Spiral Array Is a Nobel High-Throughput Technique Keeping Better Morphology)
- (一社)日本病理学会, 2011年03月, 日本病理学会会誌, 100(1) (1), 397 - 397, 英語乳癌患者のコア針生検標本中のバイオマーカーを検査するためのspiral array(Spiral Array to test biomarkers in Core Needle Biopsy from Breast Cancer Patients)
- (一社)日本病理学会, 2011年03月, 日本病理学会会誌, 100(1) (1), 501 - 501, 英語NSIPにおける病理組織所見に対応したBAL所見(BAL Findings Corresponding to Histopathology in NSIP)
- (NPO)日本肺癌学会, 2011年02月, 肺癌, 51(1) (1), 47 - 48, 日本語抗NMDA受容体抗体関連脳症を合併した小細胞肺癌の1例
- 2010年11月, RESPIROLOGY, 15, 10 - 10, 英語PATHOLOGICAL CLASSIFICATION OF INTERSTITIAL LUNG DISEASE研究発表ペーパー・要旨(国際会議)
- (一社)呼吸研究, 2010年04月, 呼吸, 29(4) (4), 377 - 390, 日本語画像診断 びまん性肺疾患の画像診断のこつ のう胞性陰影
- 富山救急医療学会, 2009年08月, 富山救急医療研究会, 27回, 10 - 10, 日本語集学的治療により救命しえた劇症型A群連鎖球菌感染症の2例
- (一社)日本呼吸器学会, 2009年05月, 日本呼吸器学会雑誌, 47(増刊) (増刊), 34 - 34, 日本語急速進行性の間質性肺炎の病態をめぐって 急速進行性の間質性肺炎と病理
- (株)日本臨床社, 2009年03月, 日本臨床, 別冊(呼吸器症候群III) (呼吸器症候群III), 60 - 64, 日本語【呼吸器症候群(第2版) その他の呼吸器疾患を含めて】 腫瘍性疾患 上皮性(原発性)腫瘍 乳頭腫
- (一社)日本病理学会, 2009年03月, 日本病理学会会誌, 98(1) (1), 399 - 399, 日本語バイオインフォマティクスと組織アレイを用いた予後・治療効果予測因子の探索
- (NPO)日本呼吸器内視鏡学会, 2008年05月, 気管支学, 30(Suppl.) (Suppl.), S102 - S102, 日本語
- (一社)日本病理学会, 2008年03月, 日本病理学会会誌, 97(1) (1), 158 - 158, 日本語肺癌研究における新たなエンティティとテクノロジー 高集積組織アレイ研究から試みる肺癌の個別化医療
- (一社)日本病理学会, 2008年03月, 日本病理学会会誌, 97(1) (1), 390 - 390, 英語HTLV-1キャリアにおける瀰漫性肺粟粒病変の3症例:HABA非定型の提唱(Three cases of diffuse pulmonary miliary lesions in HTLV-1 careers: Proposed variant of "HABA")
- (一社)日本病理学会, 2008年03月, 日本病理学会会誌, 97(1) (1), 393 - 393, 英語肺癌患者の救済療法薬としての細胞質JAB1(Cytoplasmic JAB1 act as rescuer in the patients with lung cancer)
- (一社)日本病理学会, 2008年03月, 日本病理学会会誌, 97(1) (1), 397 - 397, 英語広汎な筋線維芽細胞の増殖を伴う胎盤性"血管腫"(Placental "hemangioma" with an extensive myofibroblastic proliferation)
- (NPO)日本肺癌学会, 2007年10月, 肺癌, 47(5) (5), 661 - 661, 英語癌性間質 新しい生物指標探索の場 組織マイクロアッセイ分析(Cancerous stroma: a place to look for new biomarkers: Tissue microarray analysis)
- 金原出版(株), 2007年10月, 臨床放射線, 52(10) (10), 1215 - 1225, 日本語【呼吸器における薬剤有害反応と感染症】 薬剤性肺障害の病理 病理診断の役割
- (一社)日本病理学会, 2006年04月, 日本病理学会会誌, 95(1) (1), 381 - 381, 英語肺の粘膜表皮癌の脱分化 2症例報告(Dedifferentiation in Pulmonary Mucoepidermoid carcinoma: Report of 2 Cases)
- (公社)日本臨床細胞学会, 2006年03月, 日本臨床細胞学会雑誌, 45(Suppl.1) (Suppl.1), 283 - 283, 英語
- (一社)日本解剖学会, 2005年03月, 解剖学雑誌, 80(Suppl.) (Suppl.), 168 - 168, 英語左心室遊離壁の動脈枝の定量解析(Quantitative analysis of arterial branches of the left ventricular free wall)
- (一社)日本解剖学会, 2005年03月, 解剖学雑誌, 80(Suppl.) (Suppl.), 168 - 168, 日本語内腸骨静脈の走行異常を伴った重複下大静脈
- (一社)日本解剖学会, 2005年03月, 解剖学雑誌, 80(Suppl.) (Suppl.), 256 - 256, 日本語橈骨神経と尺骨神経の交通枝の3例
- (一社)日本解剖学会, 2005年03月, 解剖学雑誌, 80(Suppl.) (Suppl.), 258 - 258, 日本語肝臓内の動脈の走行とCouinaudの肝区域との関係
- (一社)日本解剖学会, 2005年03月, 解剖学雑誌, 80(Suppl.) (Suppl.), 259 - 259, 日本語95歳女性に見られた二分肋骨の1例
- 共著, Interstitial pneumonia, McGraw-Hill Education, 2015年10月Lung and Pleural Pathology
- 共訳, 西村書店, 2007年03月マーティン神経解剖学―テキストとアトラス
- 日本リウマチ学会, 2025年04月, 日本語膠原病に伴う間質性肺疾患における 肺生検の意義、およびその活用[招待有り]口頭発表(招待・特別)
- 日本病理学会総会, 2025年04月, 日本語間質性肺炎 基本的な見かた[招待有り]口頭発表(招待・特別)
- 第22回若手のためのびまん性肺疾患研究会, 2024年12月, 日本語喫煙関連肺疾患 病理の観点から[招待有り]口頭発表(基調)
- 第86回 浜松びまん性肺疾患研究会, 2024年11月, 日本語クライオ肺生検での病理診断の役割[招待有り]口頭発表(招待・特別)
- 第32回香川びまん性肺疾患研究会, 2024年10月, 日本語クライオ肺生検の見かた・考え方 病理から見た肺癌背景肺[招待有り]口頭発表(招待・特別)
- 第113回日本病理学会総会, 2024年03月, 日本語肺癌切除検体に見られる様々な病変・肺癌背景肺の報告事項[招待有り]シンポジウム・ワークショップパネル(指名)
- 第42回日本画像医学会, 2024年02月2013年特発性間質性肺炎 ステートメントを斬る - 病理診断に関する残された課題 -[招待有り]口頭発表(招待・特別)
- 第20回若手のためのびまん性肺疾患勉強会, 2023年12月IgG4関連肺疾患 病理学の観点から[招待有り]
- 第11回Clinical Forum of Interstitial Lung Disease, 2023年10月病理学の眼で見るびまん性肺疾患[招待有り]口頭発表(招待・特別)
- 第83回浜松びまん性肺疾患研究会, 2023年03月, 日本語病理から見た Interstitial lung abnormalities[招待有り]口頭発表(招待・特別)
- 第40回埼玉膠原病肺研究会, 2023年03月, 日本語病理像から見た関節リウマチの多様性[招待有り]口頭発表(招待・特別)
- 第42回画像医学会, 2023年02月, 日本語間質性肺炎合併肺がん術後急性増悪を病理から考える[招待有り]口頭発表(招待・特別)
- 第16回びまん性肺疾患フォーラム, 2022年12月, 日本語RAの肺病理総論 -慢性線維化性ILDを中心に-[招待有り]口頭発表(招待・特別)
- 第23回東京びまん性肺疾患研究会, 2022年10月, 日本語間質性肺炎急性増悪 up to date[招待有り]口頭発表(招待・特別)
- 第42回岡山胸部画像病理カンファレンス, 2022年09月, 日本語病理から見たInterstitial lung abnormalities[招待有り]口頭発表(招待・特別)
- 第111回日本病理学会総会, 2022年04月剖検での間質性肺炎症例におけるCPCの論点[招待有り]口頭発表(招待・特別)
- 第15回びまん性肺疾患フォーラム, 2021年12月今までのARDS/DADとCOVID-19は違うのか?組織像から考える[招待有り]口頭発表(招待・特別)
- 第80回浜松びまん性肺疾患研究会, 2021年10月早期のIPFの病理像[招待有り]口頭発表(招待・特別)
- 第32回びまん性肺疾患勉強会, 2021年05月, 日本語IPFの多様性と他疾患との境界領域[招待有り]口頭発表(招待・特別)
- 第110回日本病理学会総会, 2021年04月, 日本語特発性肺線維症のガイドライン診断[招待有り]シンポジウム・ワークショップパネル(指名)
- 第14回若手のためのびまん性肺疾患勉強会, 2020年12月, 日本語組織像からMPO-ANCA陽性の間質性肺炎を考える[招待有り]口頭発表(招待・特別)
- 第39回画像医学会, 2020年02月, 日本語強皮症に伴う肺病変の病理[招待有り]シンポジウム・ワークショップパネル(指名)
- 第11回若手のためのびまん肺勉強会, 2018年07月, 日本語, 国内会議間質性肺炎合併肺癌の病理[招待有り]口頭発表(招待・特別)
- 第97回間質性肺疾患研究会, 2018年06月, 日本語, 国内会議PPFEの概観 UIPとの関連において 病理[招待有り]口頭発表(基調)
- 第37回日本画像医学会, 2018年02月, 日本語, 国内会議皮膚筋炎合併間質性肺炎の病理[招待有り]シンポジウム・ワークショップパネル(指名)
- 第3回初歩から学ぶびまん性肺疾患セミナー, 2018年01月, 日本語, 国内会議間質性肺炎の病理 初歩編[招待有り]公開講演,セミナー,チュートリアル,講習,講義等
- 第11回びまん性肺疾患フォーラム, 2017年12月, 日本語, 国内会議IPF急性増悪の病理[招待有り]口頭発表(招待・特別)
- Pulmonary Pathology Society Biennial Meeting 2017, 2017年06月, 英語, Pulmonary Pathology Society, シカゴ、USA, 国際会議Update on rare idiopathic interstitial pneumonias.[招待有り]口頭発表(招待・特別)
- Asia Pacific International Academy of Pathology 2017, 2017年04月, 英語, 国際会議Diagnostic approach to interstitial pneumonia based on 2013 ATS/ERS classification.[招待有り]口頭発表(招待・特別)
- 第36回日本画像医学会, 2017年02月, 日本語, 国内会議急性・亜急性経過の間質性肺炎の病理像[招待有り]口頭発表(招待・特別)
- XXXI International Congress of the IAP and 28th Congress of the ESP, 2016年09月, 英語, 国際会議Rare idiopathic interstinal pneumonias and histologic patterns in new ATS/ERS classification[招待有り]口頭発表(招待・特別)
- 第6回若手のためのびまん肺勉強会, 2016年06月, 日本語, 国内会議関節リウマチ関連肺疾患の病理像[招待有り]口頭発表(招待・特別)
- 第105回日本病理学会総会JPPSコンパニオンミーティング, 2016年05月, 日本語, 国内会議抗ARS抗体症候群の病理[招待有り]口頭発表(招待・特別)
- 第9回びまん性肺疾患フォーラム, 2015年12月, 日本語, 国内会議Subacute interstitial pneumonia ないしfibrosing OP の病理診断[招待有り]口頭発表(招待・特別)
- JCRミッドサマーセミナー, 2014年07月, 日本語, 国内会議間質性肺炎の病理『ATS-ERS IIPs Classification』[招待有り]口頭発表(招待・特別)
- 第32回日本サルコイドーシス/肉芽腫性疾患学会総会, 2012年10月, 日本語, 国内会議サルコイドーシス/肉芽腫性肺疾患の病理[招待有り]口頭発表(招待・特別)
